Search of human proteins with 111154078

Search of human proteins with 111154078

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|111154078 pleckstrin homology domain containing family G
member 5 isoform c [Homo sapiens]
         (1062 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|111154078 pleckstrin homology domain containing family G memb...  2140   0.0  
gi|111154084 pleckstrin homology domain containing family G memb...  2138   0.0  
gi|38373682 pleckstrin homology domain containing family G membe...  2017   0.0  
gi|111154088 pleckstrin homology domain containing family G memb...  2017   0.0  
gi|111154080 pleckstrin homology domain containing family G memb...  2017   0.0  
gi|222080070 pleckstrin homology domain-containing family G memb...   421   e-117
gi|222080068 pleckstrin homology domain-containing family G memb...   421   e-117
gi|222080066 pleckstrin homology domain-containing family G memb...   421   e-117
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...   145   2e-34
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...   136   9e-32
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...   136   9e-32
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...   136   9e-32
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...   132   2e-30
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...   132   2e-30
gi|51972240 pleckstrin homology domain containing, family G (wit...   101   4e-21
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    99   2e-20
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             85   4e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    83   1e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    83   1e-15
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    82   3e-15
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    82   3e-15
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                80   1e-14
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]        79   3e-14
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]        79   3e-14
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]        79   3e-14
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...    78   4e-14
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]              77   7e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    77   9e-14
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor...    73   2e-12
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor...    73   2e-12

>gi|111154078 pleckstrin homology domain containing family G member 5
            isoform c [Homo sapiens]
          Length = 1062

 Score = 2140 bits (5544), Expect = 0.0
 Identities = 1062/1062 (100%), Positives = 1062/1062 (100%)

Query: 1    MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD 60
            MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD
Sbjct: 1    MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD 60

Query: 61   GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA 120
            GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA
Sbjct: 61   GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA 120

Query: 121  RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ 180
            RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ
Sbjct: 121  RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ 180

Query: 181  SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER 240
            SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER
Sbjct: 181  SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER 240

Query: 241  VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKN 300
            VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKN
Sbjct: 241  VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKN 300

Query: 301  RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD 360
            RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD
Sbjct: 301  RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD 360

Query: 361  EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC 420
            EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC
Sbjct: 361  EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC 420

Query: 421  CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG 480
            CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG
Sbjct: 421  CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG 480

Query: 481  FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
            FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP
Sbjct: 481  FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540

Query: 541  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR 600
            HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR
Sbjct: 541  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR 600

Query: 601  IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY 660
            IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY
Sbjct: 601  IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY 660

Query: 661  CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF 720
            CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF
Sbjct: 661  CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF 720

Query: 721  QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG 780
            QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG
Sbjct: 721  QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG 780

Query: 781  EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS 840
            EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS
Sbjct: 781  EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS 840

Query: 841  DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP 900
            DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP
Sbjct: 841  DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP 900

Query: 901  ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE 960
            ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE
Sbjct: 901  ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE 960

Query: 961  LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA 1020
            LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA
Sbjct: 961  LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA 1020

Query: 1021 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062
            SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Sbjct: 1021 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062


>gi|111154084 pleckstrin homology domain containing family G member 5
            isoform b [Homo sapiens]
          Length = 1083

 Score = 2138 bits (5539), Expect = 0.0
 Identities = 1061/1061 (100%), Positives = 1061/1061 (100%)

Query: 2    DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG 61
            DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG
Sbjct: 23   DDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDG 82

Query: 62   HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR 121
            HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR
Sbjct: 83   HVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKAR 142

Query: 122  RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS 181
            RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS
Sbjct: 143  RRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQS 202

Query: 182  NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV 241
            NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV
Sbjct: 203  NTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERV 262

Query: 242  DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR 301
            DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR
Sbjct: 263  DAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNR 322

Query: 302  AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE 361
            AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE
Sbjct: 323  AASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDE 382

Query: 362  DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC 421
            DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC
Sbjct: 383  DEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCC 442

Query: 422  LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF 481
            LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF
Sbjct: 443  LLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGF 502

Query: 482  KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH 541
            KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH
Sbjct: 503  KMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPH 562

Query: 542  QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI 601
            QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI
Sbjct: 563  QRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI 622

Query: 602  DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC 661
            DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC
Sbjct: 623  DAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYC 682

Query: 662  FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ 721
            FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ
Sbjct: 683  FLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQ 742

Query: 722  ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE 781
            ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE
Sbjct: 743  ASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGE 802

Query: 782  DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD 841
            DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD
Sbjct: 803  DSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSD 862

Query: 842  ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE 901
            ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE
Sbjct: 863  ETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPE 922

Query: 902  SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL 961
            SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL
Sbjct: 923  SPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSEL 982

Query: 962  CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS 1021
            CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS
Sbjct: 983  CLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGAS 1042

Query: 1022 PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062
            PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Sbjct: 1043 PRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1083


>gi|38373682 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 2017 bits (5225), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 57   MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 116
            MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS
Sbjct: 1    MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60

Query: 117  KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 176
            KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI
Sbjct: 61   KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120

Query: 177  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 236
            YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP
Sbjct: 121  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180

Query: 237  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 296
            ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD
Sbjct: 181  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240

Query: 297  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 356
            SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE
Sbjct: 241  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300

Query: 357  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 416
            EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN
Sbjct: 301  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360

Query: 417  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 476
            LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD
Sbjct: 361  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420

Query: 477  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 536
            FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM
Sbjct: 421  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480

Query: 537  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 596
            LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA
Sbjct: 481  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540

Query: 597  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 656
            VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK
Sbjct: 541  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600

Query: 657  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 716
            MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG
Sbjct: 601  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660

Query: 717  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 776
            AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE
Sbjct: 661  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720

Query: 777  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 836
            EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF
Sbjct: 721  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780

Query: 837  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 896
            SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV
Sbjct: 781  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840

Query: 897  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 956
            PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR
Sbjct: 841  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900

Query: 957  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1016
            SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL
Sbjct: 901  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960

Query: 1017 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062
            PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Sbjct: 961  PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006


>gi|111154088 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 2017 bits (5225), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 57   MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 116
            MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS
Sbjct: 1    MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60

Query: 117  KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 176
            KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI
Sbjct: 61   KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120

Query: 177  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 236
            YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP
Sbjct: 121  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180

Query: 237  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 296
            ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD
Sbjct: 181  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240

Query: 297  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 356
            SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE
Sbjct: 241  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300

Query: 357  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 416
            EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN
Sbjct: 301  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360

Query: 417  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 476
            LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD
Sbjct: 361  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420

Query: 477  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 536
            FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM
Sbjct: 421  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480

Query: 537  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 596
            LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA
Sbjct: 481  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540

Query: 597  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 656
            VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK
Sbjct: 541  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600

Query: 657  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 716
            MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG
Sbjct: 601  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660

Query: 717  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 776
            AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE
Sbjct: 661  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720

Query: 777  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 836
            EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF
Sbjct: 721  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780

Query: 837  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 896
            SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV
Sbjct: 781  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840

Query: 897  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 956
            PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR
Sbjct: 841  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900

Query: 957  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1016
            SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL
Sbjct: 901  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960

Query: 1017 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062
            PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Sbjct: 961  PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006


>gi|111154080 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 2017 bits (5225), Expect = 0.0
 Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)

Query: 57   MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 116
            MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS
Sbjct: 1    MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLS 60

Query: 117  KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 176
            KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI
Sbjct: 61   KKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDI 120

Query: 177  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 236
            YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP
Sbjct: 121  YLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPP 180

Query: 237  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 296
            ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD
Sbjct: 181  ALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGD 240

Query: 297  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 356
            SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE
Sbjct: 241  SWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWE 300

Query: 357  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 416
            EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN
Sbjct: 301  EEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIIN 360

Query: 417  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 476
            LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD
Sbjct: 361  LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420

Query: 477  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 536
            FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM
Sbjct: 421  FLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDM 480

Query: 537  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 596
            LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA
Sbjct: 481  LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAA 540

Query: 597  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 656
            VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK
Sbjct: 541  VVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSK 600

Query: 657  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 716
            MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG
Sbjct: 601  MDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVG 660

Query: 717  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 776
            AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE
Sbjct: 661  AYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEE 720

Query: 777  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 836
            EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF
Sbjct: 721  EEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPF 780

Query: 837  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 896
            SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV
Sbjct: 781  SSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELV 840

Query: 897  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 956
            PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR
Sbjct: 841  PRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSR 900

Query: 957  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 1016
            SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL
Sbjct: 901  SLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDL 960

Query: 1017 PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1062
            PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Sbjct: 961  PSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV 1006


>gi|222080070 pleckstrin homology domain-containing family G member 6
            isoform b [Homo sapiens]
          Length = 758

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 305  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 364
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106

Query: 365  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 424
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161

Query: 425  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 484
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221

Query: 485  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 544
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281

Query: 545  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 604
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341

Query: 605  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 664
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401

Query: 665  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 724
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461

Query: 725  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 784
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504

Query: 785  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 844
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556

Query: 845  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 903
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612

Query: 904  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 957
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669

Query: 958  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1017
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714

Query: 1018 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1062
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758


>gi|222080068 pleckstrin homology domain-containing family G member 6
            isoform a [Homo sapiens]
          Length = 790

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 305  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 364
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 82   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138

Query: 365  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 424
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 139  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193

Query: 425  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 484
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 194  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253

Query: 485  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 544
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 254  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313

Query: 545  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 604
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 314  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373

Query: 605  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 664
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 374  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433

Query: 665  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 724
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 434  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493

Query: 725  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 784
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 494  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536

Query: 785  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 844
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 537  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588

Query: 845  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 903
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 589  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644

Query: 904  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 957
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 645  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701

Query: 958  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1017
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 702  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746

Query: 1018 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1062
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 747  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790


>gi|222080066 pleckstrin homology domain-containing family G member 6
            isoform a [Homo sapiens]
          Length = 790

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 305  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 364
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 82   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138

Query: 365  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 424
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 139  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193

Query: 425  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 484
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 194  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253

Query: 485  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 544
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 254  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313

Query: 545  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 604
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 314  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373

Query: 605  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 664
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 374  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433

Query: 665  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 724
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 434  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493

Query: 725  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 784
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 494  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536

Query: 785  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 844
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 537  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588

Query: 845  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 903
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 589  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644

Query: 904  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 957
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 645  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701

Query: 958  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1017
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 702  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746

Query: 1018 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1062
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 747  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score =  145 bits (367), Expect = 2e-34
 Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)

Query: 196  GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 254
            G   ++K   K   EG+ +   +   S+  P  RP+     A+ R ++ Q  R    +  
Sbjct: 573  GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632

Query: 255  PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 306
            P           +   S    E +  G  P    S S+ SG+S S   G   +N   S+ 
Sbjct: 633  PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689

Query: 307  SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 353
             G  +S P  +  G               +D++++ E ++   +  G P+  R  +FD  
Sbjct: 690  VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746

Query: 354  SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 411
            ++ E   EDE  +N       +W++L+     L  + C   +QE + EL +TE +++R L
Sbjct: 747  AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806

Query: 412  RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 471
            +V+  +F      +   G+L   E  ++FSN+ +I QLH  L   + A  + K   T  +
Sbjct: 807  KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861

Query: 472  LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 528
             Q G D L  F   G   L      +C  +   +E ++   + +  F+ ++  AE +P C
Sbjct: 862  DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921

Query: 529  QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 588
            +RL+L D++    QRLTKYPLLL ++ + TE P  +E V        + +++VN  +++ 
Sbjct: 922  RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981

Query: 589  QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 648
            + +QRL     R+D   +  S    V+    E  +LDLT           R+++ EG L 
Sbjct: 982  ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027

Query: 649  MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 694
             K  +D  +D+Y  L  D+L++ +                  A+      P + +  ++ 
Sbjct: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087

Query: 695  RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 754
            R++      L +      S  GA  ++   Q +      T++  Q+ + ++ A     S 
Sbjct: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139

Query: 755  QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 808
            +P+   QS   E D  EE+  + +EE+ G   +G  +      +  +  S  P S   ++
Sbjct: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199

Query: 809  DGSTETLAMVVVE 821
             G +E   + V E
Sbjct: 1200 SGKSEVRDLFVAE 1212


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score =  136 bits (343), Expect = 9e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 376 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 428
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 471

Query: 429 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 484
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 472 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 519

Query: 485 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 543
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 520 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 579

Query: 544 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 603
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 580 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 639

Query: 604 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 663
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 640 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 685

Query: 664 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 708
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 686 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 745

Query: 709 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 761
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 746 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 803

Query: 762 EEEDEQEEEEEEEEEEE 778
           E  +   E    +   E
Sbjct: 804 ENGNGGRETSPADARTE 820


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score =  136 bits (343), Expect = 9e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 376 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 428
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423

Query: 429 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 484
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471

Query: 485 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 543
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531

Query: 544 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 603
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591

Query: 604 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 663
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637

Query: 664 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 708
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697

Query: 709 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 761
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755

Query: 762 EEEDEQEEEEEEEEEEE 778
           E  +   E    +   E
Sbjct: 756 ENGNGGRETSPADARTE 772


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score =  136 bits (343), Expect = 9e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 376 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 428
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 456

Query: 429 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 484
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 457 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 504

Query: 485 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 543
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 505 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 564

Query: 544 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 603
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 565 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 624

Query: 604 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 663
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 625 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 670

Query: 664 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 708
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 671 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 730

Query: 709 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 761
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 731 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 788

Query: 762 EEEDEQEEEEEEEEEEE 778
           E  +   E    +   E
Sbjct: 789 ENGNGGRETSPADARTE 805


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score =  132 bits (331), Expect = 2e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 386  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 768  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 824

Query: 446  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 501
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 825  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 879

Query: 502  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 561
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 880  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 939

Query: 562  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 620
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 940  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 995

Query: 621  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 672
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 996  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1045

Query: 673  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 725
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 1046 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1104

Query: 726  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 773
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 1105 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1164

Query: 774  EEEEEEG 780
            E EE  G
Sbjct: 1165 EPEELPG 1171


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score =  132 bits (331), Expect = 2e-30
 Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)

Query: 386  LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445
            LT+R+  +QE + EL  TEAS++R LRV+  +F      +++  L+   E  RLF N+PE
Sbjct: 728  LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784

Query: 446  IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 501
            + ++H   W   M    +K R    +++    L   +  G     L +   ++C  +   
Sbjct: 785  LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839

Query: 502  MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 561
            +E ++   R    F+ ++  AE HPQC+RL+L D++    QRLTKYPLLL+S+++ TE  
Sbjct: 840  LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899

Query: 562  RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 620
             ++ E +          + +VN  ++Q + R RL     R+DA  +  +S    + L  E
Sbjct: 900  TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955

Query: 621  FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 672
            F  LDLT          TR+++ EG L  +  KD  +D++  L  DLL++ +        
Sbjct: 956  FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005

Query: 673  ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 725
                  AV  ++  +   P L ++ ++ R +  D  +F +I  ++       Y   A   
Sbjct: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064

Query: 726  ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 773
            +    W++ +  A +N  +   A        PPG ++P Q     S  E +D      E 
Sbjct: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124

Query: 774  EEEEEEG 780
            E EE  G
Sbjct: 1125 EPEELPG 1131


>gi|51972240 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 7 [Homo sapiens]
          Length = 379

 Score =  101 bits (251), Expect = 4e-21
 Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)

Query: 417 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 476
           +F+  L  LQ    L +V+  RLF+N+ E+ Q       S+   + +    +  +    D
Sbjct: 2   IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60

Query: 477 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 534
           F+     +  GSL + +  YC+     + Y+  L R  D F  Y+ W E++ QC+RL + 
Sbjct: 61  FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119

Query: 535 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 594
           ++L  P QRLT+YPLLLK++ +++ +   K  + ++   VE+ I  +   ++     Q+ 
Sbjct: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179

Query: 595 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 649
             +   I    + +        + +  + KE +  ++ +P        +R LL EG L +
Sbjct: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232

Query: 650 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 683
            E     +DVY FLF D LLVTK                           +K+     V+
Sbjct: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291

Query: 684 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
             P+ +D++V + +            +FL+ + N +   + A+  QA  + + + W+  I
Sbjct: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351

Query: 736 YNA 738
             A
Sbjct: 352 TTA 354


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)

Query: 317 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 372
           S+ GR   KM + +G         L +  +    D DS EE   +++  D   +     L
Sbjct: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414

Query: 373 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 427
             +W +L     K     +++ +  +QEA++E++ +E SY+  L ++I +F     N +E
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470

Query: 428 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 485
            S  + + E   LFSNI ++ +  ++ +       LE   +    +    D ++  K   
Sbjct: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523

Query: 486 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 545
           S F PY++YC  E      ++ LL  N  F+  ++  E H  C+ L +   L  P QR+T
Sbjct: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583

Query: 546 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 605
           + PLL+ ++ +KT +   K  V       +R +  V+  +R   E  R      +++  E
Sbjct: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631

Query: 606 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 658
           ++ + + +++  +K F       P+  +S    R L+  G L        +   + SK  
Sbjct: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680

Query: 659 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 693
           VY FLF D+L++TK  KK+E +  +    L D+++
Sbjct: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)

Query: 384 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 443
           ++L+  +  +QEA++E+L +E SY   L +++  FL    + +    + ++E   LFSNI
Sbjct: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332

Query: 444 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 502
            ++    +R +       LE+  + + L++   D L+  +     F PYI YC  E    
Sbjct: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385

Query: 503 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 561
             ++ L+  N  FR  +   E+ P C  L +   L  P QR+T+ PLL+ ++  KT+   
Sbjct: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445

Query: 562 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 621
              +A    + ++ + +   N    + +  +++  + +++D  +V               
Sbjct: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490

Query: 622 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 675
                + P+  AS    R LL  G L + E         S+   Y FLF D+L+VTK  K
Sbjct: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540

Query: 676 KAERTRVIRP-----PLLVDKIVCRELRDPG 701
           K+E + +++       + V+KI   EL  PG
Sbjct: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 85/366 (23%), Positives = 160/366 (43%), Gaps = 47/366 (12%)

Query: 393  QQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRR 452
            +Q  + EL+ TE  Y+  L++++ +F      + ESG L E E   +F N  E+   + +
Sbjct: 1183 RQGYIHELIQTEERYMADLQLVVEVFQ---KRMAESGFLTEGEMALIFVNWKELIMSNTK 1239

Query: 453  LWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRD 511
            L  ++   V +K    +  +Q  GD L       S  + YIR+C  +      ++    +
Sbjct: 1240 LLKALR--VRKKTGGEKMPVQMIGDILAAEL---SHMQAYIRFCSCQLNGAALLQQKTDE 1294

Query: 512  NDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM- 570
            +  F+ ++      P+C+ + LS  L KP QR+T+YPLL++S+L  T E  A  + + + 
Sbjct: 1295 DTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1354

Query: 571  IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 630
            +   E     VN  +R+++   RL  + + +           + + L ++ +   LT  +
Sbjct: 1355 LERAEELCSQVNEGVREKENSDRLEWIQAHV-----------QCEGLAEQLIFNSLTNCL 1403

Query: 631  PGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKK-------------- 676
                    R+LL  G L   +   S  +++ FLF D LL+T  VK+              
Sbjct: 1404 ------GPRKLLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSK 1454

Query: 677  -AERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
               + ++ + P+ +++++ +   DP S   ++       V  YT +         WV  I
Sbjct: 1455 SNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRV--YTLRTDNINERTAWVQKI 1512

Query: 736  YNAQNQ 741
              A  Q
Sbjct: 1513 KAASEQ 1518


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 85/366 (23%), Positives = 160/366 (43%), Gaps = 47/366 (12%)

Query: 393  QQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRR 452
            +Q  + EL+ TE  Y+  L++++ +F      + ESG L E E   +F N  E+   + +
Sbjct: 1210 RQGYIHELIQTEERYMADLQLVVEVFQ---KRMAESGFLTEGEMALIFVNWKELIMSNTK 1266

Query: 453  LWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRD 511
            L  ++   V +K    +  +Q  GD L       S  + YIR+C  +      ++    +
Sbjct: 1267 LLKALR--VRKKTGGEKMPVQMIGDILAAEL---SHMQAYIRFCSCQLNGAALLQQKTDE 1321

Query: 512  NDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM- 570
            +  F+ ++      P+C+ + LS  L KP QR+T+YPLL++S+L  T E  A  + + + 
Sbjct: 1322 DTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1381

Query: 571  IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 630
            +   E     VN  +R+++   RL  + + +           + + L ++ +   LT  +
Sbjct: 1382 LERAEELCSQVNEGVREKENSDRLEWIQAHV-----------QCEGLAEQLIFNSLTNCL 1430

Query: 631  PGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKK-------------- 676
                    R+LL  G L   +   S  +++ FLF D LL+T  VK+              
Sbjct: 1431 ------GPRKLLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSK 1481

Query: 677  -AERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
               + ++ + P+ +++++ +   DP S   ++       V  YT +         WV  I
Sbjct: 1482 SNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRV--YTLRTDNINERTAWVQKI 1539

Query: 736  YNAQNQ 741
              A  Q
Sbjct: 1540 KAASEQ 1545


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)

Query: 353 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 391
           D+ EEE +E+E+E+ A           CL        + W++L +       E L   + 
Sbjct: 121 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 180

Query: 392 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 451
             QEA++EL+ +EASY + L ++++ F+    N +   +L   EA  LFSN+ ++  +  
Sbjct: 181 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 237

Query: 452 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 510
           R        +LE   R    +   D     ++     F  YI Y   +       + LL+
Sbjct: 238 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 290

Query: 511 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 570
           +   FR  I   E  P+C+ L  S  L  P QR+T+  LL++++L++ EE   +E     
Sbjct: 291 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 348

Query: 571 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 630
           + + +     V AC    ++  R   ++S                 + K+      + PI
Sbjct: 349 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 391

Query: 631 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 681
              S    R LL +G L+   G  +           ++Y FLF DLL++ + +   +   
Sbjct: 392 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 447

Query: 682 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
               P  + ++   EL D G      F+L  L         Y  +AS Q+  + W+ ++
Sbjct: 448 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 504



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)

Query: 736 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 778
           Y  ++ LQ++  R Q+    +         ED  EEEEEEEEEEE
Sbjct: 90  YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 134


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)

Query: 353 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 391
           D+ EEE +E+E+E+ A           CL        + W++L +       E L   + 
Sbjct: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272

Query: 392 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 451
             QEA++EL+ +EASY + L ++++ F+    N +   +L   EA  LFSN+ ++  +  
Sbjct: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329

Query: 452 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 510
           R        +LE   R    +   D     ++     F  YI Y   +       + LL+
Sbjct: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382

Query: 511 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 570
           +   FR  I   E  P+C+ L  S  L  P QR+T+  LL++++L++ EE   +E     
Sbjct: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440

Query: 571 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 630
           + + +     V AC    ++  R   ++S                 + K+      + PI
Sbjct: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483

Query: 631 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 681
              S    R LL +G L+   G  +           ++Y FLF DLL++ + +   +   
Sbjct: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539

Query: 682 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
               P  + ++   EL D G      F+L  L         Y  +AS Q+  + W+ ++
Sbjct: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)

Query: 736 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 778
           Y  ++ LQ++  R Q+    +         ED  EEEEEEEEEEE
Sbjct: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 75/303 (24%), Positives = 136/303 (44%), Gaps = 48/303 (15%)

Query: 384  EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 443
            + LT  +  +Q  + EL+ TE +Y+  L+++  +F   L+   ES LL E E   +F N 
Sbjct: 1229 DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLM---ESELLTEKEVAMIFVNW 1285

Query: 444  PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLF-------KPYIRYCM 496
             E+   + +L          KA R R  +  G+ +   KM G +        +PYIR+C 
Sbjct: 1286 KELIMCNIKLL---------KALRVRKKMS-GEKMP-VKMIGDILSAQLPHMQPYIRFCS 1334

Query: 497  EEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLR 556
             +      ++    +   F+ ++      P+C+ + LS  + KP QR+T+YPL++K++L 
Sbjct: 1335 RQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILE 1394

Query: 557  KTEEPRAKEA-VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVES-SSDEV 614
             T E     + +   +   E     VN  +R+++   RL  + + +    + E    + V
Sbjct: 1395 NTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSV 1454

Query: 615  DKLL--KEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 672
               L  ++FLH                      S ++ + K +K ++Y FLF D LL+T+
Sbjct: 1455 TNCLGPRKFLH----------------------SGKLYKAKSNK-ELYGFLFNDFLLLTQ 1491

Query: 673  AVK 675
              K
Sbjct: 1492 ITK 1494


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 374  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031

Query: 430  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090

Query: 485  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150

Query: 541  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210

Query: 600  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254

Query: 660  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312

Query: 713  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351

Query: 773  EEEEE 777
            EEE++
Sbjct: 2352 EEEKK 2356


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 374 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429
           +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272

Query: 430 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484
           LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331

Query: 485 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
           G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391

Query: 541 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599
            QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451

Query: 600 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659
           + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495

Query: 660 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712
              L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553

Query: 713 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772
             V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592

Query: 773 EEEEE 777
           EEE++
Sbjct: 593 EEEKK 597


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 374  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027

Query: 430  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086

Query: 485  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146

Query: 541  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206

Query: 600  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250

Query: 660  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308

Query: 713  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347

Query: 773  EEEEE 777
            EEE++
Sbjct: 2348 EEEKK 2352


>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
           sapiens]
          Length = 802

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 25/288 (8%)

Query: 386 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445
           L+ R C  QEA +EL+ +EASYI  L V +  FL    + + S  L   + + LFS +PE
Sbjct: 370 LSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLG---SAELSECLGAQDKQWLFSKLPE 426

Query: 446 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYM 505
           +     R    +   +     R        D    F+    ++ PY+     +E    Y 
Sbjct: 427 VKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRR---VYLPYVTNQAYQE--RTYQ 481

Query: 506 RGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKE 565
           R LL +N  F   +   E+ P CQRL L+  L  P QR+T+  +L++++L++T +    E
Sbjct: 482 R-LLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE 540

Query: 566 AVVA-MIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHL 624
            +      +++  +   NA ++  +  + L  +  +I     +     +   L++    +
Sbjct: 541 DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV 600

Query: 625 DLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK 672
           +L AP+P A P +               K S   VY  LF D LL+++
Sbjct: 601 EL-APLPAAPPAKL--------------KLSSKAVYLHLFNDCLLLSR 633


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 384 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 443
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465

Query: 444 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 503
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519

Query: 504 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 563
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579

Query: 564 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 606
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 835  PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 892
            P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 47   PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103

Query: 893  AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 949
            +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 104  SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163

Query: 950  ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 999
                  AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 164  RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222

Query: 1000 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 1029
             L   P G + +    +P  ASP    R +P PP
Sbjct: 223  -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 103/414 (24%), Positives = 170/414 (41%), Gaps = 67/414 (16%)

Query: 376 WRELID--GHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCE 433
           W E++D    E LT R+  +QEA++E+   E   I  L++    +   +L L    ++ E
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212

Query: 434 VEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIR 493
            E   +F ++     LH  L    +  + E  +    + Q G  L  +    + ++ Y  
Sbjct: 213 EELTHIFGDLDSYIPLHEDL----LTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCS 268

Query: 494 YCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKS 553
             +  +  ++  +   R  D  +  +    + P  ++L L   L  P  RL KYPLLLK 
Sbjct: 269 NQLAAKALLDQKKQDPRVQDFLQRCL----ESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324

Query: 554 VLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDE 613
           +L+ T  P+    V  +  ++                   +  V+S I+  +        
Sbjct: 325 ILKHT--PKEHPDVQLLEDAI-----------------LIIQGVLSDINLKKGESECQYY 365

Query: 614 VDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKA 673
           +DKL  E+L      P      E ++ LL  G LR K G      +Y FLF D+L++T+ 
Sbjct: 366 IDKL--EYLDEKQRDP----RIEASKVLLCHGELRSKSGH----KLYIFLFQDILVLTRP 415

Query: 674 VKKAER--TRVIRPPLLVDKIVCRELRD-----PGSFLLIYLN----------EFH--SA 714
           V + ER   +V R P+ V ++V  +L+D      GSF   + N           FH  S 
Sbjct: 416 VTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475

Query: 715 VGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQE 768
             ++T QA+     + W + I  A    Q        GS   LQ L E  +E E
Sbjct: 476 AQSHTLQANDVFHKQQWFNCIRAAIAPFQS------AGSPPELQGLPELHEECE 523


>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
           [Homo sapiens]
          Length = 985

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)

Query: 374 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 431
           DSW   +D    ++  +    QQ+ ++EL+ TE  ++R L+++  LF         +G+L
Sbjct: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265

Query: 432 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 478
            E+  E      LF  + E++ +H R     ++ +LE+ R        R   + + GD L
Sbjct: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321

Query: 479 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 533
                F       + K Y  +C      ++  + L   +  F+ +I    +    +R  +
Sbjct: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379

Query: 534 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 590
            + +    QR+TKYPLL+  +L+ +   EE R  + +   +G V+  + +V+  + Q ++
Sbjct: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437

Query: 591 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 645
             RL  + +R+D                          P+PG  P   EE   R+L+ +G
Sbjct: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476

Query: 646 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 701
            L  K       DV   L TD+L+  +   +      +  P +V    ++ R++  ++ G
Sbjct: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536

Query: 702 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 761
            FL+       +    Y    + +     W+  I       QQ     P     PL   E
Sbjct: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584

Query: 762 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 797
           +E   +  + E ++++                    + E+ G S  + PT+ R     +S
Sbjct: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644

Query: 798 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 853
             SP  +    D     E L  ++V PG + L +P   + P    S   TS   TA+   
Sbjct: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704

Query: 854 PT 855
            T
Sbjct: 705 RT 706


>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
           [Homo sapiens]
          Length = 986

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)

Query: 374 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 431
           DSW   +D    ++  +    QQ+ ++EL+ TE  ++R L+++  LF         +G+L
Sbjct: 215 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 266

Query: 432 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 478
            E+  E      LF  + E++ +H R     ++ +LE+ R        R   + + GD L
Sbjct: 267 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 322

Query: 479 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 533
                F       + K Y  +C      ++  + L   +  F+ +I    +    +R  +
Sbjct: 323 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 380

Query: 534 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 590
            + +    QR+TKYPLL+  +L+ +   EE R  + +   +G V+  + +V+  + Q ++
Sbjct: 381 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 438

Query: 591 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 645
             RL  + +R+D                          P+PG  P   EE   R+L+ +G
Sbjct: 439 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 477

Query: 646 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 701
            L  K       DV   L TD+L+  +   +      +  P +V    ++ R++  ++ G
Sbjct: 478 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 537

Query: 702 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 761
            FL+       +    Y    + +     W+  I       QQ     P     PL   E
Sbjct: 538 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 585

Query: 762 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 797
           +E   +  + E ++++                    + E+ G S  + PT+ R     +S
Sbjct: 586 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 645

Query: 798 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 853
             SP  +    D     E L  ++V PG + L +P   + P    S   TS   TA+   
Sbjct: 646 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 705

Query: 854 PT 855
            T
Sbjct: 706 RT 707


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,301,664
Number of Sequences: 37866
Number of extensions: 2860110
Number of successful extensions: 52571
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 706
Number of HSP's successfully gapped in prelim test: 856
Number of HSP's that attempted gapping in prelim test: 28102
Number of HSP's gapped (non-prelim): 14178
length of query: 1062
length of database: 18,247,518
effective HSP length: 113
effective length of query: 949
effective length of database: 13,968,660
effective search space: 13256258340
effective search space used: 13256258340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.