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Search of human proteins with 110611237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 1425 0.0
gi|13540563 complement factor H-related 5 [Homo sapiens] 274 2e-73
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 259 6e-69
gi|118442839 complement factor H-related 1 [Homo sapiens] 171 3e-42
gi|239758113 PREDICTED: similar to complement factor H-related 1... 171 3e-42
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 165 1e-40
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 165 1e-40
gi|54792787 complement factor H-related 3 [Homo sapiens] 162 1e-39
gi|5031695 H factor (complement)-like 3 [Homo sapiens] 157 4e-38
gi|117320518 complement factor H-related 4 [Homo sapiens] 156 7e-38
gi|239758115 PREDICTED: similar to complement factor H-related 1... 148 1e-35
gi|148886654 polydom [Homo sapiens] 144 3e-34
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 125 1e-28
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 125 1e-28
gi|157419154 selectin P precursor [Homo sapiens] 118 2e-26
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 118 2e-26
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 118 2e-26
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 118 2e-26
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 114 2e-25
gi|153266841 apolipoprotein H precursor [Homo sapiens] 113 6e-25
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 112 1e-24
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 110 3e-24
gi|4502503 complement component 4 binding protein, alpha chain p... 108 2e-23
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 108 2e-23
gi|187960042 selectin E precursor [Homo sapiens] 98 3e-20
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 87 4e-17
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 87 4e-17
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 87 4e-17
gi|148539593 sushi domain containing 4 isoform a [Homo sapiens] 86 1e-16
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 84 3e-16
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 1425 bits (3689), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL 60
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
Sbjct: 1 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL 60
Query: 61 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS 120
AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
Sbjct: 61 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS 120
Query: 121 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC 180
GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
Sbjct: 121 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC 180
Query: 181 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF 240
ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
Sbjct: 181 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF 240
Query: 241 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI 300
CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
Sbjct: 241 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI 300
Query: 301 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV 360
ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
Sbjct: 301 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV 360
Query: 361 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS 420
TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
Sbjct: 361 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS 420
Query: 421 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD 480
VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
Sbjct: 421 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD 480
Query: 481 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV 540
LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
Sbjct: 481 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV 540
Query: 541 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF 600
DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
Sbjct: 541 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF 600
Query: 601 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR 660
DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
Sbjct: 601 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR 660
Query: 661 T 661
T
Sbjct: 661 T 661
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 274 bits (700), Expect = 2e-73
Identities = 178/572 (31%), Positives = 262/572 (45%), Gaps = 42/572 (7%)
Query: 91 CTKPDLSNGYISDVKLLYKIQ-----ENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPT 145
C P + +G++ D + E Y C + + + C +GWS P
Sbjct: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 146 CRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLT 205
C + C P + NG+ ++ D VQ C TGY +K + C+ GWS
Sbjct: 83 CLR---MCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKN--ISCVERGWSTP 137
Query: 206 PKC--TKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPE 263
P C TK +C L N P K++Y+ GDV++F C +N GSD +QCY FGW P
Sbjct: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPN 197
Query: 264 SPVCEGRRNRCPPPPLPINSKI-QTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWT 322
P C+G+ C PPP N ++ + Y H E+V +C NF I+G +I+C DG+WT
Sbjct: 198 FPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWT 257
Query: 323 EPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGK 382
P C+E + C P +E G Y +G V C++ Y + G+N ITC G
Sbjct: 258 TLPTCVE--QVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGI 315
Query: 383 WTLPPECVENNE--NCKHPPVVMNGAVA-DGILASYATGSSVEYRCNEYYLLRGSKISRC 439
WT P CV ++ CK V + + G + S + YRC++ + R S C
Sbjct: 316 WTELPMCVATHQLKRCKIAGVNIKTLLKLSG--KEFNHNSRIRYRCSDIFRYRHSV---C 370
Query: 440 EQGKWSSPPVCLEP----CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
GKW+ C E C N N+ Y+ G+ + +CK+ Y L
Sbjct: 371 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQD----GEKVAVLCKENY----L 422
Query: 496 TPLSELSVQCNRGEVK-YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF 554
P ++ + C G + P C ES C PP I +G S + Y GS+V YRC
Sbjct: 423 LPEAK-EIVCKDGRWQSLPRCV--ESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQ 479
Query: 555 DHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEF 614
+ L+GS C + W+ PP CL+PC +S M KNN+ LKW D + + G+ +EF
Sbjct: 480 SFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEF 539
Query: 615 ICRGDTYPAELYITGSILRMQCDRGQLKYPRC 646
C+ +P + I+ R C G+ +YP C
Sbjct: 540 QCK---FPHKAMISSPPFRAICQEGKFEYPIC 568
Score = 246 bits (628), Expect = 5e-65
Identities = 156/504 (30%), Positives = 235/504 (46%), Gaps = 35/504 (6%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
C FP V+NG ++ S + D + C GY+ ++ E+ +C GWS
Sbjct: 87 CSFPFVKNG------HSESSGLIHLEGDT-VQIICNTGYSLQNN--EKNISCVERGWSTP 137
Query: 85 PRC-FKK--CTKPDL-SNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGW 140
P C F K C P L +N K YK+ + +++ C G + VQC GW
Sbjct: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGS---DSVQCYQFGW 194
Query: 141 SSQ-PTCRKEHETC-LAPELYNGNYSTTQKT-FKVKDKVQYECATGYYTAGGKKTEEVEC 197
S PTC+ + +C P+L NG +K + + V+Y+C + G KK ++C
Sbjct: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKK---IQC 251
Query: 198 LTYGWSLTPKCTKL--KCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQC 255
+ W+ P C + C + +E GY P Y+ G V+ C Y + G+++I C
Sbjct: 252 VDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC 311
Query: 256 YNFGWYPESPVCEGRRN--RCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAE 313
N G + E P+C RC + I + ++ + H + C F S
Sbjct: 312 IN-GIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSV- 369
Query: 314 IRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGS 373
C +GKW C E +E+ C PP I N + Y +G+KV CK YLL +
Sbjct: 370 --CINGKWNPEVDCTEKREQF-CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA 426
Query: 374 NEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRG 433
EI C G+W P CVE+ C PP + NG L+ Y GS+V YRC +Y L+G
Sbjct: 427 KEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG 486
Query: 434 SKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVL--HGDLIDFVCKQGYD 491
S C +WS PP CL+PC V+ + MN+NNI++KW+ +GK+ GD ++F CK +
Sbjct: 487 SVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHK 546
Query: 492 LSPLTPLSELSVQCNRGEVKYPLC 515
+P C G+ +YP+C
Sbjct: 547 AMISSP--PFRAICQEGKFEYPIC 568
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 259 bits (662), Expect = 6e-69
Identities = 183/694 (26%), Positives = 290/694 (41%), Gaps = 146/694 (21%)
Query: 23 KPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWS 82
KPC +P +++G + Y+ + YFP+++ K S++C + T SG + CT +GWS
Sbjct: 323 KPCDYPDIKHGGL--YHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWS 380
Query: 83 PEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSS 142
P C +KC P L NGY + + +++ C GY K + V C+ +GWS
Sbjct: 381 PAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALP--KAQTTVTCMENGWSP 438
Query: 143 QPTCRKEHETC--LAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTY 200
P C + +TC + ++ NG S +Q T+ +K+K +Y+C GY TA G+ + + C
Sbjct: 439 TPRCIRV-KTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD 497
Query: 201 GWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENY--------------Y 246
GWS P C +K + + N ++ D + + CH+ Y Y
Sbjct: 498 GWSAQPTC--IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGY 555
Query: 247 LSGSDLIQC-----------------------------------------------YNFG 259
SDL C Y+FG
Sbjct: 556 NGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG 615
Query: 260 WYPESPVCEGRRNRCPPPPLPINSKIQTHS-TTYRHGEIVHIECELNFEIHGSAEIRCED 318
P+ P+C+ + C PPP +N ++ + Y H E+V C F + G +I+C D
Sbjct: 616 LSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD 675
Query: 319 GKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC 378
G+WT P CI E+ C + P +E+G A L S YY GD V + C + + G ITC
Sbjct: 676 GEWTTLPVCI--VEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC 733
Query: 379 NRGKWTLPPECV--------------------------ENNENCKH---------PPVVM 403
G WT P+CV ++N N ++ V +
Sbjct: 734 IHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCI 793
Query: 404 NGAVADGILASYA----------------TGSSVEYR--------CNEYYLLRGSKISRC 439
NG + S A +++ YR C E YL++ + C
Sbjct: 794 NGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC 853
Query: 440 EQGKWSSPPVCLE--PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTP 497
+ G+W S P+C+E PC+ + I + HG + + C+ G+ +S
Sbjct: 854 KDGRWQSIPLCVEKIPCS-QPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS---- 908
Query: 498 LSELSVQCNRGEVKYPLCTRKESKGM-CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDH 556
E C G+ P + +G+ C SPP I HGV+ + D+Y+ G V Y+CF+
Sbjct: 909 -EENETTCYMGKWSSP----PQCEGLPCKSPPEISHGVVAHMS-DSYQYGEEVTYKCFEG 962
Query: 557 HFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
++G A CL W+ PP C++ LS E
Sbjct: 963 FGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFE 996
Score = 250 bits (638), Expect = 3e-66
Identities = 184/670 (27%), Positives = 277/670 (41%), Gaps = 98/670 (14%)
Query: 51 IDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE-PRCFKKCTK----PDLSNGYISD-V 104
+ + L F C G+T + C G SP+ P C ++ P+L NG + +
Sbjct: 589 VGEVLKFSCKPGFTIVGPNSVQ---CYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKT 645
Query: 105 KLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCL-APELYNGNY 163
K Y E + Y C + G +QC+ W++ P C E TC PEL +G
Sbjct: 646 KEEYGHSEVVEYYCNPRFLMKGPNK---IQCVDGEWTTLPVCIVEESTCGDIPELEHGWA 702
Query: 164 STTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKL----KCSSLRLI 219
+ + D V++ C+ + G + + C+ W+ P+C + KC S LI
Sbjct: 703 QLSSPPYYYGDSVEFNCSESFTMIGHRS---ITCIHGVWTQLPQCVAIDKLKKCKSSNLI 759
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPL 279
K+ ++ +++ C G C N W PE + CPPPP
Sbjct: 760 ILEEHLKNKKEFDHNSNIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQ 816
Query: 280 PINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEP 339
NS T + YR GE V + C+ N+ I EI C+DG+W P C+E K+ C +P
Sbjct: 817 IPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVE---KIPCSQP 873
Query: 340 PFIENGAANLH---SKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPE-------- 388
P IE+G N + Y +G K++Y C+ G+ + NE TC GKW+ PP+
Sbjct: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKS 933
Query: 389 -------------------------CVEN------------NENCKHPPVVMN------- 404
C E E HPP +
Sbjct: 934 PPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLP 993
Query: 405 ---GAVADGILAS-YATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDY 460
A+ G Y G V Y C YY + G+ C +W+ P C + VN
Sbjct: 994 SFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPT 1053
Query: 461 MNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE-VKYPLCTRKE 519
+ N + + K G+ + + C+ Y++ + V C G + P C K+
Sbjct: 1054 VQ--NAYIVSRQMSKYPSGERVRYQCRSPYEM-----FGDEEVMCLNGNWTEPPQC--KD 1104
Query: 520 SKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCL 579
S G C PP I +G I S + Y SSVEY+C + + LEG++ C +G W+ PP CL
Sbjct: 1105 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCL 1164
Query: 580 EPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRG 639
PC +S ME N+ L+W + + GE +EF+C+ L LR C G
Sbjct: 1165 HPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRG---YRLSSRSHTLRTTCWDG 1221
Query: 640 QLKYPRCIPR 649
+L+YP C R
Sbjct: 1222 KLEYPTCAKR 1231
Score = 156 bits (394), Expect = 7e-38
Identities = 158/710 (22%), Positives = 270/710 (38%), Gaps = 144/710 (20%)
Query: 4 KNLTFIIILIISGELYA-------EEKPCGFPH--------VENGRIAQYYYTFKSFYFP 48
++L +I++ GE A +++PCG P + G + +Y
Sbjct: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY---------- 106
Query: 49 MSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE-PRC-FKKC---TKPDLSNGYISD 103
K + C GY + C T+GW+ + P C KC T P+ NG I
Sbjct: 107 ---GVKAVYTCNEGYQLLG--EINYRECDTDGWTNDIPICEVVKCLPVTAPE--NGKIVS 159
Query: 104 VKLL----YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELY 159
+ Y + +R+ C SGYK G +E + C DG+ S+ + +C +P++
Sbjct: 160 SAMEPDREYHFGQAVRFVCNSGYKIEG---DEEMHCSDDGFWSKEKPKCVEISCKSPDVI 216
Query: 160 NGNYSTTQKTFKVKDKVQYECATGY-YTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRL 218
NG+ + + +K ++ QY+C GY Y+ G + C GW P C + C +
Sbjct: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERG----DAVCTESGWRPLPSCEEKSCDN-PY 271
Query: 219 IENGYFHPVKQTYEEGDVVQFFCHENYY-LSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
I NG + P++ + GD + + C +Y + + +C + GW P +P C C P
Sbjct: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDYP 328
Query: 278 PLP----INSKIQTHSTTYRHGEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEG 330
+ + ++ G+ C+ +FE + I C W+ C+
Sbjct: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLR- 387
Query: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLL-HGSNEITCNRGKWTLPPEC 389
C P++ENG H + + G + AC GY L +TC W+ P C
Sbjct: 388 ----KCYF-PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKIS---RCEQGKWSS 446
+ K + NG +++ +YA +Y+C Y+ + S C + WS+
Sbjct: 443 IRVKTCSKSSIDIENGFISES-QYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSA 501
Query: 447 PPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
P C++ C + V R + W D +D+ C GY+ + T + S+ C
Sbjct: 502 QPTCIKSCDIPVFMNARTKNDFTW-----FKLNDTLDYECHDGYESN--TGSTTGSIVCG 554
Query: 507 -RGEVKYPLCTRKESK-------------------------------------------- 521
G P+C +E +
Sbjct: 555 YNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHF 614
Query: 522 GMCTSPPLIK-------------HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL 568
G+ P+ K +G + T + Y + VEY C ++G + C+
Sbjct: 615 GLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV 674
Query: 569 DGMWTTPPLCL--EPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFIC 616
DG WTT P+C+ E E+E W + P +G+ +EF C
Sbjct: 675 DGEWTTLPVCIVEESTCGDIPELEHG-----WAQLSSPPYYYGDSVEFNC 719
Score = 66.2 bits (160), Expect = 9e-11
Identities = 83/327 (25%), Positives = 118/327 (36%), Gaps = 40/327 (12%)
Query: 274 CPPPPLPINSKIQTHS---TTYRHGEIVHIECELNFEIHGSAEIRCEDGKW---TEPPKC 327
C P N++I T S TY G +C + G+ + C G+W KC
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
Query: 328 IEGQEKVACEEPPFIENGAANL-HSKIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTL 385
+K C P G L ++ G K Y C GY L G N C+ WT
Sbjct: 81 ----QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTN 136
Query: 386 P-PECVENNENCKHPPVVM--NGAVADGIL---ASYATGSSVEYRCNEYYLLRGSKISRC 439
P C E K PV NG + + Y G +V + CN Y + G + C
Sbjct: 137 DIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
Query: 440 -EQGKWS-SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTP 497
+ G WS P C+E + D +N + I K Y+ + + C GY+ S
Sbjct: 193 SDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYK----ENERFQYKCNMGYEYSERGD 248
Query: 498 LSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHH 557
+V G P C K P I +G + + G + Y+C +
Sbjct: 249 ----AVCTESGWRPLPSCEEKSCDN-----PYIPNGDYSPLRI-KHRTGDEITYQCRNGF 298
Query: 558 F-LEGSREAYCLDGMWTTPPLC-LEPC 582
+ A C W P C L+PC
Sbjct: 299 YPATRGNTAKCTSTGWIPAPRCTLKPC 325
Score = 60.5 bits (145), Expect = 5e-09
Identities = 73/304 (24%), Positives = 111/304 (36%), Gaps = 36/304 (11%)
Query: 354 YYNGDKVTYACKSGYLLHGSNEITCNRGKW-TLPPECVENNENCKHPPVVMNG--AVADG 410
Y G + Y C+ GY G+ + C +G+W L P C HP G + G
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Query: 411 ILASYATGSSVEYRCNEYYLLRGS-KISRCEQGKWSSP-PVC-LEPCTVNVDYMNRNNIE 467
+ Y G Y CNE Y L G C+ W++ P+C + C N +
Sbjct: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
Query: 468 MKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG---EVKYPLCTRKESKGMC 524
+ + + G + FVC GY + + + C+ + P C C
Sbjct: 160 SAMEPDREYHFGQAVRFVCNSGYKIE-----GDEEMHCSDDGFWSKEKPKCVEIS----C 210
Query: 525 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL 584
SP +I +G IS + Y+ +Y+C + +A C + W P C E
Sbjct: 211 KSPDVI-NGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC- 267
Query: 585 SFTEMEKNNLLLKWDFDNRPHILH--GEYIEFICRGDTYPAELYITGSILRMQCDRGQLK 642
N + D+ + I H G+ I + CR YPA T G +
Sbjct: 268 ------DNPYIPNGDY-SPLRIKHRTGDEITYQCRNGFYPATRGNTAKC----TSTGWIP 316
Query: 643 YPRC 646
PRC
Sbjct: 317 APRC 320
Score = 42.4 bits (98), Expect = 0.001
Identities = 48/199 (24%), Positives = 78/199 (39%), Gaps = 22/199 (11%)
Query: 394 ENCKHPPVVMNGAVADGILA--SYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCL 451
E+C P N + G + +Y G+ Y+C Y G+ I C +G+W V L
Sbjct: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW----VAL 74
Query: 452 EP---CTVN-VDYMNRNNIEMKWKYEGKVL-HGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
P C + G V +G + C +GY L L ++ +
Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL--LGEINYRECDTD 132
Query: 507 RGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVD---TYENGSSVEYRCFDHHFLEGSR 563
P+C + C ++G I+SS ++ Y G +V + C + +EG
Sbjct: 133 GWTNDIPICEVVK----CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
Query: 564 EAYCL-DGMWT-TPPLCLE 580
E +C DG W+ P C+E
Sbjct: 189 EMHCSDDGFWSKEKPKCVE 207
Score = 37.7 bits (86), Expect = 0.034
Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 17/128 (13%)
Query: 28 PHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRC 87
P ++NG I + S Y P S + + C Y E ++ TC WS P+C
Sbjct: 1113 PPIDNGDITSFPL---SVYAPAS---SVEYQCQNLYQLEGNKR---ITCRNGQWSEPPKC 1163
Query: 88 FKKCT-------KPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGW 140
C +++ + + KL + E++ + C GY+ + C DG
Sbjct: 1164 LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCW-DGK 1222
Query: 141 SSQPTCRK 148
PTC K
Sbjct: 1223 LEYPTCAK 1230
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 171 bits (432), Expect = 3e-42
Identities = 94/292 (32%), Positives = 142/292 (48%), Gaps = 16/292 (5%)
Query: 234 GDVVQFFCHENYYLSGSDL---IQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHST 290
G+V + C N+ I C GW P +P C R P N ++
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSP-TPKCL----RLCFFPFVENGHSESSGQ 102
Query: 291 TYRHGEIVHIECELNFEIHGSAE-IRCEDGKWTEPPKCIEGQEKVACEEPPFIENG-AAN 348
T+ G+ V I C + + + I C + W+ PPKC +C PP ++N +
Sbjct: 103 THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC--RSTDTSCVNPPTVQNAHILS 160
Query: 349 LHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVA 408
Y +G++V Y C+S Y + G E+ C G WT PP+C ++ C PP + NG +
Sbjct: 161 RQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468
L+ YA SSVEY+C Y L G+K C G+WS PP CL PC ++ + M NI +
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIAL 280
Query: 469 KWKYEGKVL--HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
+W + K+ G+ +FVCK+GY LS + L C G+++YP C ++
Sbjct: 281 RWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 330
Score = 133 bits (334), Expect = 6e-31
Identities = 90/299 (30%), Positives = 141/299 (47%), Gaps = 22/299 (7%)
Query: 357 GDKVTYACKSGYLLHGSN---EITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILA 413
G+ Y+C+ ++ + ITC W+ P+C+ C P V + + G
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL---CFFPFVENGHSESSG--Q 102
Query: 414 SYATGSSVEYRCNEYYLLRGSK--ISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWK 471
++ G +V+ CN Y L+ ++ IS E+G WS+PP C T V+ N + +
Sbjct: 103 THLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCVNPPTVQNAHILSR 161
Query: 472 YEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE-VKYPLCTRKESKGMCTSPPLI 530
K G+ + + C+ Y++ + V C G + P C K+S G C PP I
Sbjct: 162 QMSKYPSGERVRYECRSPYEM-----FGDEEVMCLNGNWTEPPQC--KDSTGKCGPPPPI 214
Query: 531 KHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
+G I S + Y SSVEY+C + + LEG++ C +G W+ PP CL PC +S ME
Sbjct: 215 DNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIME 274
Query: 591 KNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649
N+ L+W + ++ GE EF+C+ L LR C G+L+YP C R
Sbjct: 275 NYNIALRWTAKQKLYLRTGESAEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 104 bits (260), Expect = 2e-22
Identities = 73/257 (28%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 16 GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75
G LY EEK F V G + +YY+ C + + S + T
Sbjct: 31 GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
Query: 76 CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135
CT EGWSP P+C + C P + NG+ + + ++ C +GY+ +E + C
Sbjct: 72 CTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
Query: 136 LSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVK--DKVQYECATGYYTAGGKKTE 193
+ GWS+ P CR +C+ P + +++ K ++V+YEC + Y G E
Sbjct: 130 VERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG---DE 186
Query: 194 EVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVK-QTYEEGDVVQFFCHENYYLSGS 250
EV CL W+ P+C + KC I+NG Y V++ C Y L G+
Sbjct: 187 EVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 246
Query: 251 DLIQCYNFGWYPESPVC 267
I C N G + E P C
Sbjct: 247 KRITCRN-GQWSEPPKC 262
Score = 80.5 bits (197), Expect = 5e-15
Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 30/260 (11%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
C FP VENG T + C GY ++ E +C GWS
Sbjct: 87 CFFPFVENGHSESSGQTHLE-------GDTVQIICNTGYRLQNN--ENNISCVERGWSTP 137
Query: 85 PRCFKKCTK----PDLSNGYISDVKLL-YKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
P+C T P + N +I ++ Y E +RY C S Y+ G DEEV+ CL+
Sbjct: 138 PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG--DEEVM-CLNGN 194
Query: 140 WSSQPTCRKEHETC-LAPELYNGNYSTTQ-KTFKVKDKVQYECATGYYTAGGKKTEEVEC 197
W+ P C+ C P + NG+ ++ + V+Y+C Y G K+ + C
Sbjct: 195 WTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR---ITC 251
Query: 198 LTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENYYLSG-S 250
WS PKC S ++EN Y ++ T ++ G+ +F C Y LS S
Sbjct: 252 RNGQWSEPPKCLHPCVISREIMEN-YNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
Query: 251 DLIQCYNFGWYPESPVCEGR 270
++ + E P C R
Sbjct: 311 HTLRTTCWDGKLEYPTCAKR 330
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 171 bits (432), Expect = 3e-42
Identities = 94/292 (32%), Positives = 142/292 (48%), Gaps = 16/292 (5%)
Query: 234 GDVVQFFCHENYYLSGSDL---IQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHST 290
G+V + C N+ I C GW P +P C R P N ++
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSP-TPKCL----RLCFFPFVENGHSESSGQ 102
Query: 291 TYRHGEIVHIECELNFEIHGSAE-IRCEDGKWTEPPKCIEGQEKVACEEPPFIENG-AAN 348
T+ G+ V I C + + + I C + W+ PPKC +C PP ++N +
Sbjct: 103 THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC--RSTDTSCVNPPTVQNAHILS 160
Query: 349 LHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVA 408
Y +G++V Y C+S Y + G E+ C G WT PP+C ++ C PP + NG +
Sbjct: 161 RQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468
L+ YA SSVEY+C Y L G+K C G+WS PP CL PC ++ + M NI +
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIAL 280
Query: 469 KWKYEGKVL--HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
+W + K+ G+ +FVCK+GY LS + L C G+++YP C ++
Sbjct: 281 RWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 330
Score = 133 bits (334), Expect = 6e-31
Identities = 90/299 (30%), Positives = 141/299 (47%), Gaps = 22/299 (7%)
Query: 357 GDKVTYACKSGYLLHGSN---EITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILA 413
G+ Y+C+ ++ + ITC W+ P+C+ C P V + + G
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL---CFFPFVENGHSESSG--Q 102
Query: 414 SYATGSSVEYRCNEYYLLRGSK--ISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWK 471
++ G +V+ CN Y L+ ++ IS E+G WS+PP C T V+ N + +
Sbjct: 103 THLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCVNPPTVQNAHILSR 161
Query: 472 YEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE-VKYPLCTRKESKGMCTSPPLI 530
K G+ + + C+ Y++ + V C G + P C K+S G C PP I
Sbjct: 162 QMSKYPSGERVRYECRSPYEM-----FGDEEVMCLNGNWTEPPQC--KDSTGKCGPPPPI 214
Query: 531 KHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
+G I S + Y SSVEY+C + + LEG++ C +G W+ PP CL PC +S ME
Sbjct: 215 DNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIME 274
Query: 591 KNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649
N+ L+W + ++ GE EF+C+ L LR C G+L+YP C R
Sbjct: 275 NYNIALRWTAKQKLYLRTGESAEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 104 bits (260), Expect = 2e-22
Identities = 73/257 (28%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 16 GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75
G LY EEK F V G + +YY+ C + + S + T
Sbjct: 31 GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
Query: 76 CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135
CT EGWSP P+C + C P + NG+ + + ++ C +GY+ +E + C
Sbjct: 72 CTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
Query: 136 LSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVK--DKVQYECATGYYTAGGKKTE 193
+ GWS+ P CR +C+ P + +++ K ++V+YEC + Y G E
Sbjct: 130 VERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG---DE 186
Query: 194 EVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVK-QTYEEGDVVQFFCHENYYLSGS 250
EV CL W+ P+C + KC I+NG Y V++ C Y L G+
Sbjct: 187 EVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 246
Query: 251 DLIQCYNFGWYPESPVC 267
I C N G + E P C
Sbjct: 247 KRITCRN-GQWSEPPKC 262
Score = 80.5 bits (197), Expect = 5e-15
Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 30/260 (11%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
C FP VENG T + C GY ++ E +C GWS
Sbjct: 87 CFFPFVENGHSESSGQTHLE-------GDTVQIICNTGYRLQNN--ENNISCVERGWSTP 137
Query: 85 PRCFKKCTK----PDLSNGYISDVKLL-YKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
P+C T P + N +I ++ Y E +RY C S Y+ G DEEV+ CL+
Sbjct: 138 PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG--DEEVM-CLNGN 194
Query: 140 WSSQPTCRKEHETC-LAPELYNGNYSTTQ-KTFKVKDKVQYECATGYYTAGGKKTEEVEC 197
W+ P C+ C P + NG+ ++ + V+Y+C Y G K+ + C
Sbjct: 195 WTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR---ITC 251
Query: 198 LTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENYYLSG-S 250
WS PKC S ++EN Y ++ T ++ G+ +F C Y LS S
Sbjct: 252 RNGQWSEPPKCLHPCVISREIMEN-YNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
Query: 251 DLIQCYNFGWYPESPVCEGR 270
++ + E P C R
Sbjct: 311 HTLRTTCWDGKLEYPTCAKR 330
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 165 bits (417), Expect = 1e-40
Identities = 152/571 (26%), Positives = 247/571 (43%), Gaps = 79/571 (13%)
Query: 25 CGFPH-VENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG--- 80
CG P + NGRI+ YY T P+++ + + C + E+ C T+
Sbjct: 23 CGSPPPILNGRIS-YYST------PIAVGTVIRYSCSGTFRLIG---EKSLLCITKDKVD 72
Query: 81 --WS-PEPRC-----FKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEV 132
W P P+C + C +P + GY Y+ +++ + C + + G K
Sbjct: 73 GTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS--- 129
Query: 133 VQCLSD---GWSSQPTCRKEH--ETCLAPELYNGNYSTTQKTFKVKD--KVQYECATGYY 185
V C ++ G + PTC E P ++NG++ T++ + V Y C +GY
Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHH-TSENVGSIAPGLSVTYSCESGYL 188
Query: 186 TAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQT--YEEGDVVQFFC 241
G K + CL+ G WS + P C + +C SL NG VK+ G FFC
Sbjct: 189 LVGEKI---INCLSSGKWSAVPPTCEEARCKSLGRFPNG---KVKEPPILRVGVTANFFC 242
Query: 242 HENYYLSGSDLIQCYNFGW---YPESPVCEGRRNRCPPPPLPINSK-IQTHSTTYRHGEI 297
E Y L G +C G + + PVCE CP PP +N + I +G I
Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCE--EIFCPSPPPILNGRHIGNSLANVSYGSI 300
Query: 298 VHIECE------LNFEIHGSAEIRC-----EDGKWTEP-PKCIEGQEKVACEEPPFIENG 345
V C+ +NF + G + +RC + G W+ P P+C V C P +
Sbjct: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
Query: 346 AANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNENCKHPPVVMN 404
+ Y D V +AC G+ L GS +I CN +G W P + C+ PP ++N
Sbjct: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWE--PSAPVCEKECQAPPNILN 418
Query: 405 GAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP-PVCLEPCTVNVDYMN 462
G D + + G+S++Y CN Y+L G + +C +G W+ P P C V
Sbjct: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC------KVAACE 472
Query: 463 RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKG 522
++ K + + + D ++ C +GY LS + +C +G + + + R +
Sbjct: 473 ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLS-----GSVYQEC-QGTIPWFMEIRLCKEI 525
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
C PP+I +G S+++ + G++V Y C
Sbjct: 526 TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC 556
Score = 122 bits (307), Expect = 8e-28
Identities = 145/572 (25%), Positives = 233/572 (40%), Gaps = 86/572 (15%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPE-PRCFKKCTKPDLSNGYISDVKLLYKIQE 112
+ + C GY EE CT+EG W+P P+C K + + + ++
Sbjct: 435 IKYSCNPGYVLVG---EESIQCTSEGVWTPPVPQC--KVAACEATGRQLLTKPQHQFVRP 489
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYS-TTQKTFK 171
++ C GYK +G +E + W + KE P +YNG ++ ++ + F
Sbjct: 490 DVNSSCGEGYKLSGSVYQECQGTIP--WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
Query: 172 VKDKVQYECATG-----YYTAGGKKTEEVECLTYG-----WSLTPKCTKL-----KCSSL 216
V Y C G ++ G+ T + C + WS KL +CS +
Sbjct: 548 YGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHV 605
Query: 217 RLIENGYFHPVKQT-YEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEG---RR 271
I NGY K+ Y D V F C+ + L GS I+C + W PE PVCE +
Sbjct: 606 H-IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQH 664
Query: 272 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED---GKWTEP-PKC 327
R LP S++ E+V+ C+ +++ G A C+D G W + P C
Sbjct: 665 VRQSLQELPAGSRV----------ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714
Query: 328 IEGQEKVACEEPPFIENGA-ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-----RG 381
+ + C PP I NG + ++ + G++V+Y C G+ L G ++ C G
Sbjct: 715 ----KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHG 770
Query: 382 KWTLP-PECVENNENCKHP-PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC 439
W+ P P+C+ + + P P V +G + ++Y+ V CN +++ GS++ RC
Sbjct: 771 SWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830
Query: 440 EQGKWSSP--PVCLE---------PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQ 488
P P C++ P T N ++ N G I + C Q
Sbjct: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFS--------PGMSILYSCDQ 882
Query: 489 GYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGS 547
GY L + E + C + G P KE C+SP + Y+ G+
Sbjct: 883 GYLL-----VGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGA 935
Query: 548 SVEYRCFDHHFLEGSREAYCLDGMWTTPPLCL 579
V C D + LEGS ++ C PPL +
Sbjct: 936 VVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 967
Score = 103 bits (258), Expect = 4e-22
Identities = 145/622 (23%), Positives = 222/622 (35%), Gaps = 117/622 (18%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPEPRCFKKCTKPDLS---NGYISDVKLLYKI 110
+++ C +GY E+ C + G WS P ++ L NG + + +L ++
Sbjct: 179 VTYSCESGYLLVG---EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPIL-RV 234
Query: 111 QENMRYGCASGYKTTGGKDEE-VVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKT 169
+ C GY+ G V+ W+ P C + P L + +
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
Query: 170 FKVKDKVQYECATG-----YYTAGGKKTEEVECL-----TYGWS-LTPKC----TKLKCS 214
V Y C + G+ T + C T WS P+C + ++C
Sbjct: 295 VSYGSIVTYTCDPDPEEGVNFILIGEST--LRCTVDSQKTGTWSGPAPRCELSTSAVQCP 352
Query: 215 SLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNR 273
+++ K Y D V F C + L GS I+C G W P +PVCE
Sbjct: 353 HPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE---KE 409
Query: 274 CPPPPLPINS-KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PKCIEG 330
C PP +N K H + G + C + + G I+C +G WT P P+C
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC--- 466
Query: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWTLPPEC 389
KVA E + H + + V +C GY L GS C W +
Sbjct: 467 --KVAACEATGRQLLTKPQHQFVRPD---VNSSCGEGYKLSGSVYQECQGTIPWFMEIRL 521
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE------YYLLRGSKISRC---- 439
+ C PPV+ NGA L + G++V Y CN + L G RC
Sbjct: 522 CKEI-TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
Query: 440 -EQGKWSSP-PVC-LEPCTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDL--- 492
E+G WS P P+C L V +++ N ++ K E + D + F C G+ L
Sbjct: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYNDTVTFKCYSGFTLKGS 639
Query: 493 -----------SPLTPLSE----------------------LSVQCNRGEV----KYPLC 515
P P+ E ++ C G Y +C
Sbjct: 640 SQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMC 699
Query: 516 TRKESKGM------------CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSR 563
E+ G+ C PP+I +G + + G+ V Y C +L G +
Sbjct: 700 QDAEN-GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEK 758
Query: 564 EAYCLD-----GMWTTP-PLCL 579
+ C G W+ P P CL
Sbjct: 759 KLQCRSDSKGHGSWSGPSPQCL 780
Score = 57.8 bits (138), Expect = 3e-08
Identities = 58/271 (21%), Positives = 98/271 (36%), Gaps = 42/271 (15%)
Query: 334 VACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-----GKWTLP-P 387
++C PP I NG + +S G + Y+C + L G + C G W P P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 388 ECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP 447
+C N+ P ++ G Y G SV + C + + G+K C+ P
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Query: 448 ---PVCLEPCTVNVDYMNR-NNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
P C+ + + +N + G + G + + C+ GY L + E +
Sbjct: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL-----VGEKII 195
Query: 504 QC---NRGEVKYPLCTRKESK-------GMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
C + P C K G PP+++ GV + + C
Sbjct: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV-------------TANFFC 242
Query: 554 FDHHFLEGSREAYCLDG----MWTTPPLCLE 580
+ + L+G + C+ WT P+C E
Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCEE 273
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 165 bits (417), Expect = 1e-40
Identities = 152/571 (26%), Positives = 247/571 (43%), Gaps = 79/571 (13%)
Query: 25 CGFPH-VENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG--- 80
CG P + NGRI+ YY T P+++ + + C + E+ C T+
Sbjct: 23 CGSPPPILNGRIS-YYST------PIAVGTVIRYSCSGTFRLIG---EKSLLCITKDKVD 72
Query: 81 --WS-PEPRC-----FKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEV 132
W P P+C + C +P + GY Y+ +++ + C + + G K
Sbjct: 73 GTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS--- 129
Query: 133 VQCLSD---GWSSQPTCRKEH--ETCLAPELYNGNYSTTQKTFKVKD--KVQYECATGYY 185
V C ++ G + PTC E P ++NG++ T++ + V Y C +GY
Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHH-TSENVGSIAPGLSVTYSCESGYL 188
Query: 186 TAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQT--YEEGDVVQFFC 241
G K + CL+ G WS + P C + +C SL NG VK+ G FFC
Sbjct: 189 LVGEKI---INCLSSGKWSAVPPTCEEARCKSLGRFPNG---KVKEPPILRVGVTANFFC 242
Query: 242 HENYYLSGSDLIQCYNFGW---YPESPVCEGRRNRCPPPPLPINSK-IQTHSTTYRHGEI 297
E Y L G +C G + + PVCE CP PP +N + I +G I
Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCE--EIFCPSPPPILNGRHIGNSLANVSYGSI 300
Query: 298 VHIECE------LNFEIHGSAEIRC-----EDGKWTEP-PKCIEGQEKVACEEPPFIENG 345
V C+ +NF + G + +RC + G W+ P P+C V C P +
Sbjct: 301 VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR 360
Query: 346 AANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNENCKHPPVVMN 404
+ Y D V +AC G+ L GS +I CN +G W P + C+ PP ++N
Sbjct: 361 MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWE--PSAPVCEKECQAPPNILN 418
Query: 405 GAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP-PVCLEPCTVNVDYMN 462
G D + + G+S++Y CN Y+L G + +C +G W+ P P C V
Sbjct: 419 GQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC------KVAACE 472
Query: 463 RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKG 522
++ K + + + D ++ C +GY LS + +C +G + + + R +
Sbjct: 473 ATGRQLLTKPQHQFVRPD-VNSSCGEGYKLS-----GSVYQEC-QGTIPWFMEIRLCKEI 525
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
C PP+I +G S+++ + G++V Y C
Sbjct: 526 TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC 556
Score = 128 bits (322), Expect = 1e-29
Identities = 124/457 (27%), Positives = 185/457 (40%), Gaps = 62/457 (13%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WSP 83
C H+ NG Y P + ++F C +G+T + Q C + W P
Sbjct: 602 CSHVHIANG------YKISGKEAPYFYNDTVTFKCYSGFTLKGS---SQIRCKADNTWDP 652
Query: 84 E-PRCFKKC-TKPDLSNGYISDVKLLYKIQE-NMRYGCASGYKTTGGKDEEVVQCLSDG- 139
E P C K C + P L +G + ++ + + Y C GY G K + C+ G
Sbjct: 653 EIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKS---IHCMPSGN 709
Query: 140 WS-SQPTCRK--EHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVE 196
WS S P C + +H EL G+ + V C GY G +
Sbjct: 710 WSPSAPRCEETCQHVRQSLQELPAGSRV---------ELVNTSCQDGYQLTGHAYQMCQD 760
Query: 197 CLTYGW-SLTPKCTKLKCSSLRLIENG-YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQ 254
W P C + C +I NG + + + + G+ V + C + +YL G +Q
Sbjct: 761 AENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ 820
Query: 255 CYNFG-----WYPESPVC--EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFE 307
C + W SP C RCP P + K+ + Y H +IV+++C F
Sbjct: 821 CRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFI 880
Query: 308 IHGSAEIRCE-DGKWTE-PPKCIEGQEKVACEEPPFIENG---AANLHSKIYYNGDKVTY 362
++GS IRC D W P CI+ + + C PP NG N+ + G + Y
Sbjct: 881 MNGSRVIRCHTDNTWVPGVPTCIK-KAFIGCPPPPKTPNGNHTGGNIAR--FSPGMSILY 937
Query: 363 ACKSGYLLHGSNEITC-NRGKWTLP-PECVENNENCKHPPVVMNGAVADGILAS------ 414
+C GYLL G + C + G W+ P P C E NC P A DGI
Sbjct: 938 SCDQGYLLVGEALLLCTHEGTWSQPAPHCKE--VNCSSP------ADMDGIQKGLEPRKM 989
Query: 415 YATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCL 451
Y G+ V C + Y+L GS S+C+ +PP+ +
Sbjct: 990 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 1026
Score = 126 bits (316), Expect = 7e-29
Identities = 143/572 (25%), Positives = 222/572 (38%), Gaps = 73/572 (12%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPEPRCFKKCTKPDLS---NGYISDVKLLYKI 110
+++ C +GY E+ C + G WS P ++ L NG + + +L ++
Sbjct: 179 VTYSCESGYLLVG---EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPIL-RV 234
Query: 111 QENMRYGCASGYKTTGGKDEE-VVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKT 169
+ C GY+ G V+ W+ P C + P L + +
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
Query: 170 FKVKDKVQYECATG-----YYTAGGKKTEEVECL-----TYGWS-LTPKC----TKLKCS 214
V Y C + G+ T + C T WS P+C + ++C
Sbjct: 295 VSYGSIVTYTCDPDPEEGVNFILIGEST--LRCTVDSQKTGTWSGPAPRCELSTSAVQCP 352
Query: 215 SLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNR 273
+++ K Y D V F C + L GS I+C G W P +PVCE
Sbjct: 353 HPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE---KE 409
Query: 274 CPPPPLPINS-KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PKCIEG 330
C PP +N K H + G + C + + G I+C +G WT P P+C
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC--- 466
Query: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWTLPPEC 389
KVA E + H + + V +C GY L GS C W +
Sbjct: 467 --KVAACEATGRQLLTKPQHQFVRPD---VNSSCGEGYKLSGSVYQECQGTIPWFMEIRL 521
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE------YYLLRGSKISRC---- 439
+ C PPV+ NGA L + G++V Y CN + L G RC
Sbjct: 522 CKEI-TCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
Query: 440 -EQGKWSSP-PVC-LEPCTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
E+G WS P P+C L V +++ N ++ K E + D + F C G+ L
Sbjct: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK-EAPYFYNDTVTFKCYSGFTLK-- 637
Query: 496 TPLSELSVQC---NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYR 552
++C N + + P+C KG C SPP + HG + +G +V+Y
Sbjct: 638 ---GSSQIRCKADNTWDPEIPVC----EKG-CQSPPGLHHGRHTGGNTVFFVSGMTVDYT 689
Query: 553 CFDHHFLEGSREAYCL-DGMWT-TPPLCLEPC 582
C + L G++ +C+ G W+ + P C E C
Sbjct: 690 CDPGYLLVGNKSIHCMPSGNWSPSAPRCEETC 721
Score = 107 bits (267), Expect = 4e-23
Identities = 150/622 (24%), Positives = 238/622 (38%), Gaps = 127/622 (20%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPE-PRCFKKCTKPDLSNGYISDVKLLYKIQE 112
+ + C GY EE CT+EG W+P P+C K + + + ++
Sbjct: 435 IKYSCNPGYVLVG---EESIQCTSEGVWTPPVPQC--KVAACEATGRQLLTKPQHQFVRP 489
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYS-TTQKTFK 171
++ C GYK +G +E + W + KE P +YNG ++ ++ + F
Sbjct: 490 DVNSSCGEGYKLSGSVYQECQGTIP--WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547
Query: 172 VKDKVQYECATG-----YYTAGGKKTEEVECLTYG-----WSLTPKCTKL-----KCSSL 216
V Y C G ++ G+ T + C + WS KL +CS +
Sbjct: 548 YGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCKLSLLAVQCSHV 605
Query: 217 RLIENGYFHPVKQT-YEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCE------ 268
I NGY K+ Y D V F C+ + L GS I+C + W PE PVCE
Sbjct: 606 H-IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSP 664
Query: 269 -----GRRN---------------RCPPPPLPINSKIQTH--------------STTYRH 294
GR C P L + +K H T +H
Sbjct: 665 PGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNK-SIHCMPSGNWSPSAPRCEETCQH 723
Query: 295 G-------------EIVHIECELNFEIHGSAEIRCED---GKWTEP-PKCIEGQEKVACE 337
E+V+ C+ +++ G A C+D G W + P C + + C
Sbjct: 724 VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC----KVIHCH 779
Query: 338 EPPFIENGA-ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-----RGKWTLP-PECV 390
PP I NG + ++ + G++V+Y C G+ L G ++ C G W+ P P+C+
Sbjct: 780 PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 839
Query: 391 ENNENCKHP-PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP-- 447
+ + P P V +G + ++Y+ V CN +++ GS++ RC P
Sbjct: 840 RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 899
Query: 448 PVCLE---------PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL 498
P C++ P T N ++ N G I + C QGY L +
Sbjct: 900 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFS--------PGMSILYSCDQGYLL-----V 946
Query: 499 SELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHH 557
E + C + G P KE C+SP + Y+ G+ V C D +
Sbjct: 947 GEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGY 1004
Query: 558 FLEGSREAYCLDGMWTTPPLCL 579
LEGS ++ C PPL +
Sbjct: 1005 MLEGSPQSQCQSDHQWNPPLAV 1026
Score = 57.8 bits (138), Expect = 3e-08
Identities = 58/271 (21%), Positives = 98/271 (36%), Gaps = 42/271 (15%)
Query: 334 VACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-----GKWTLP-P 387
++C PP I NG + +S G + Y+C + L G + C G W P P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 388 ECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP 447
+C N+ P ++ G Y G SV + C + + G+K C+ P
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Query: 448 ---PVCLEPCTVNVDYMNR-NNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
P C+ + + +N + G + G + + C+ GY L + E +
Sbjct: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL-----VGEKII 195
Query: 504 QC---NRGEVKYPLCTRKESK-------GMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
C + P C K G PP+++ GV + + C
Sbjct: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV-------------TANFFC 242
Query: 554 FDHHFLEGSREAYCLDG----MWTTPPLCLE 580
+ + L+G + C+ WT P+C E
Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWTKMPVCEE 273
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 162 bits (409), Expect = 1e-39
Identities = 93/291 (31%), Positives = 138/291 (47%), Gaps = 18/291 (6%)
Query: 234 GDVVQFFCHENYYL-SGS--DLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHST 290
G ++C E++ SGS D I C GW P P +C P L N Q +
Sbjct: 48 GKYYSYYCDEHFETPSGSYWDYIHCTQNGWSPAVPCLR----KCYFPYLE-NGYNQNYGR 102
Query: 291 TYRHGEIVHIECELNFEI-HGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANL 349
+ G + C + + + C + W+ P+CI + + + IENG +
Sbjct: 103 KFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPTPRCI--RVRTCSKSDIEIENGFISE 160
Query: 350 HSKIYYNGDKVTYACKSGYLL---HGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGA 406
S IY ++ Y CK GY + S ITC + W+ P C+ ++E C PP + NG
Sbjct: 161 SSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGD 220
Query: 407 VADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNI 466
+L Y S VEY+C YY L+GS C G+WS PP C+ PC + + MN+NNI
Sbjct: 221 TTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNI 280
Query: 467 EMKWKYEGK--VLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLC 515
++K + + K GD I+F+CK GY+ + T + C G V+YP C
Sbjct: 281 KLKGRSDRKYYAKTGDTIEFMCKLGYNAN--TSILSFQAVCREGIVEYPRC 329
Score = 130 bits (327), Expect = 4e-30
Identities = 79/250 (31%), Positives = 115/250 (46%), Gaps = 11/250 (4%)
Query: 23 KPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWS 82
KPC FP +++G + ++ + YFP+++ K S++C + T SG + CT GWS
Sbjct: 21 KPCDFPDIKHGGL--FHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGWS 78
Query: 83 PEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSS 142
P C +KC P L NGY + + + C GY K + V C GWS
Sbjct: 79 PAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLP--KAQTTVTCTEKGWSP 136
Query: 143 QPTCRKEHETCLAP--ELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTY 200
P C + TC E+ NG S + + + ++QY+C GY TA G + + CL
Sbjct: 137 TPRCIRV-RTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQN 195
Query: 201 GWSLTPKC--TKLKCSSLRLIENGYFHP-VKQTYEEGDVVQFFCHENYYLSGSDLIQCYN 257
GWS P C + KC I NG + + Y V++ C Y L GS+ + C N
Sbjct: 196 GWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSN 255
Query: 258 FGWYPESPVC 267
W E P C
Sbjct: 256 GEW-SEPPRC 264
Score = 103 bits (256), Expect = 7e-22
Identities = 90/331 (27%), Positives = 136/331 (41%), Gaps = 27/331 (8%)
Query: 327 CIEGQEKVACEEPPFIENGAANLHSKIYYN----GDKVTYACKSGYLLHGSNE---ITCN 379
C GQ K C+ P G + + + Y G +Y C + + I C
Sbjct: 15 CANGQVK-PCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCT 73
Query: 380 RGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYY-LLRGSKISR 438
+ W+ C+ C P + + G+S E C+ Y L +
Sbjct: 74 QNGWSPAVPCLRK---CYFP--YLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVT 128
Query: 439 CEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL 498
C + WS P C+ T + + N + +L+ + I + CK GY +
Sbjct: 129 CTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKE-IQYKCKPGYATADGN-- 185
Query: 499 SELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHH 557
S S+ C G P+C K C PP I +G S + Y S VEY+C ++
Sbjct: 186 SSGSITCLQNGWSAQPICINSSEK--CGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYY 243
Query: 558 FLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICR 617
L+GS C +G W+ PP C+ PC ++ M KNN+ LK D + + G+ IEF+C+
Sbjct: 244 ELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCK 303
Query: 618 GDTYPAELYITGSILRMQ--CDRGQLKYPRC 646
Y A SIL Q C G ++YPRC
Sbjct: 304 LG-YNANT----SILSFQAVCREGIVEYPRC 329
Score = 31.6 bits (70), Expect = 2.4
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 16/102 (15%)
Query: 28 PHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRC 87
P + NG + Y P S ++ + C Y + TC+ WS PRC
Sbjct: 214 PPISNGDTTSFLL---KVYVPQS---RVEYQCQPYYELQGSNY---VTCSNGEWSEPPRC 264
Query: 88 FKKC--TKPDLSNGYI-----SDVKLLYKIQENMRYGCASGY 122
C T+ +++ I SD K K + + + C GY
Sbjct: 265 IHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
Length = 270
Score = 157 bits (396), Expect = 4e-38
Identities = 82/232 (35%), Positives = 119/232 (51%), Gaps = 17/232 (7%)
Query: 295 GEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS 351
GE+ + CE NF + I C + W+ PKC+ C P F+ENG +
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR-----LCFFP-FVENGHSESSG 101
Query: 352 KIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTLPPECVE--NNENCKHPPVVMNGAVA 408
+ + GD V C +GY L + N I+C W+ PP+C + E C PP + NG +
Sbjct: 102 QTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDIT 161
Query: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468
+L+ YA GSSVEY+C Y L G+ C G+WS PP CL+PC ++ + M + NI++
Sbjct: 162 SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
Query: 469 KWKYEGKVLH--GDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
KW + K+ GD+++FVCK GY T C G++ YP C K
Sbjct: 222 KWTNQQKLYSRTGDIVEFVCKSGYH---PTKSHSFRAMCQNGKLVYPSCEEK 270
Score = 124 bits (312), Expect = 2e-28
Identities = 79/236 (33%), Positives = 113/236 (47%), Gaps = 21/236 (8%)
Query: 417 TGSSVEYRCNEYYLLRGSK-----ISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWK 471
TG Y C EY + SK I+ E+G WS P CL C ++ + E +
Sbjct: 47 TGEVFYYSC-EYNFVSPSKSFWTRITCAEEG-WSPTPKCLRLCFF--PFVENGHSESSGQ 102
Query: 472 YEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLI 530
L GD + +C GY L +E ++ C RG P C S C PP I
Sbjct: 103 TH---LEGDTVQIICNTGYRLQN----NENNISCVERGWSTPPKCRSTISAEKCGPPPPI 155
Query: 531 KHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
+G I S + Y GSSVEY+C + + LEG+ + C +G W+ PP CL+PC +S ME
Sbjct: 156 DNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIME 215
Query: 591 KNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRC 646
K N+ LKW + + G+ +EF+C+ +P + + R C G+L YP C
Sbjct: 216 KYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSH----SFRAMCQNGKLVYPSC 267
Score = 101 bits (252), Expect = 2e-21
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 16/219 (7%)
Query: 178 YECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVV 237
Y C + + + C GWS TPKC +L +ENG+ QT+ EGD V
Sbjct: 53 YSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTV 110
Query: 238 QFFCHENYYLSGSDL-IQCYNFGWYPESPVCEGR--RNRCPPPPLPINSKIQTHS-TTYR 293
Q C+ Y L ++ I C GW P C +C PPP N I + + Y
Sbjct: 111 QIICNTGYRLQNNENNISCVERGW-STPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYA 169
Query: 294 HGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIE----GQEKVACEEPPFIENGAANL 349
G V +C+ +++ G+ +I C +G+W+EPPKC++ QE + L
Sbjct: 170 PGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKL 229
Query: 350 HSKIYYNGDKVTYACKSGYLLHGSNEI--TCNRGKWTLP 386
+S+ GD V + CKSGY S+ C GK P
Sbjct: 230 YSR---TGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYP 265
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/241 (26%), Positives = 100/241 (41%), Gaps = 35/241 (14%)
Query: 16 GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75
G LY EEK F V G + +YY+ C + + S + T
Sbjct: 31 GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
Query: 76 CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135
C EGWSP P+C + C P + NG+ + + ++ C +GY+ +E + C
Sbjct: 72 CAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
Query: 136 LSDGWSSQPTCRK--EHETC-LAPELYNGNY-STTQKTFKVKDKVQYECATGYYTAGGKK 191
+ GWS+ P CR E C P + NG+ S + V+Y+C Y G
Sbjct: 130 VERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEG--- 186
Query: 192 TEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENY 245
++ C WS PKC S ++E Y +K T ++ GD+V+F C Y
Sbjct: 187 NNQITCRNGQWSEPPKCLDPCVISQEIMEK-YNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
Query: 246 Y 246
+
Sbjct: 246 H 246
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 156 bits (394), Expect = 7e-38
Identities = 102/337 (30%), Positives = 155/337 (45%), Gaps = 26/337 (7%)
Query: 6 LTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTT 65
+ I+ L +S E KPC FP +++G + YY + + YFP + + S++C + T
Sbjct: 5 INVILTLWVSCANGQEVKPCDFPEIQHGGL--YYKSLRRLYFPAAAGQSYSYYCDQNFVT 62
Query: 66 ESGRQEEQTTCTTEGWSPEPRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYK 123
SG + CT +GWSP C + C+K D + NG+IS+ +Y + + ++Y C GY
Sbjct: 63 PSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYA 122
Query: 124 TTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATG 183
T G + CL +GWS+QP C K C P N + FK+ D + YEC G
Sbjct: 123 TADGNSSGSITCLQNGWSAQPICIK---FCDMPVFENSRAKSNGMRFKLHDTLDYECYDG 179
Query: 184 YYTAGGKKTEEVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHP-VKQTYEEGDVVQFF 240
Y + G T + C GWS P C + KC I NG + + Y V++
Sbjct: 180 YEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQ 239
Query: 241 CHENYYLSGSDLIQCYNFGWYPESPVC-------EGRRNRCPPPPLPINSKIQTHSTTYR 293
C Y L GS+ + C N W E P C E N+ L S I+ ++ T
Sbjct: 240 CQSYYELQGSNYVTCSNGEW-SEPPRCIHPCIITEENMNK-NNIQLKGKSDIKYYAKT-- 295
Query: 294 HGEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKC 327
G+ + C+L + + S + C +G E P+C
Sbjct: 296 -GDTIEFMCKLGYNANTSVLSFQAVCREG-IVEYPRC 330
Score = 152 bits (384), Expect = 9e-37
Identities = 96/308 (31%), Positives = 140/308 (45%), Gaps = 27/308 (8%)
Query: 223 YFHPVKQTY---EEGDVVQFFCHENYYL-SGS--DLIQCYNFGWYPESPVCEGRRNRCPP 276
Y+ +++ Y G ++C +N+ SGS D I C GW P P C
Sbjct: 35 YYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCLR----TCSK 90
Query: 277 PPLPI-NSKIQTHSTTYRHGEIVHIECELNFEI---HGSAEIRCEDGKWTEPPKCIEGQE 332
+ I N I S+ Y + + +C+ + + S I C W+ P CI+
Sbjct: 91 SDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIK--- 147
Query: 333 KVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSN---EITCNRGKWTLPPEC 389
C+ P F EN A + + D + Y C GY + N I C W+ P C
Sbjct: 148 --FCDMPVF-ENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTC 204
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV 449
++E C PP + NG +L Y S VEY+C YY L+GS C G+WS PP
Sbjct: 205 YNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPR 264
Query: 450 CLEPCTVNVDYMNRNNIEMKWKYEGK--VLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR 507
C+ PC + + MN+NNI++K K + K GD I+F+CK GY+ + T + C
Sbjct: 265 CIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNAN--TSVLSFQAVCRE 322
Query: 508 GEVKYPLC 515
G V+YP C
Sbjct: 323 GIVEYPRC 330
Score = 123 bits (309), Expect = 5e-28
Identities = 94/335 (28%), Positives = 147/335 (43%), Gaps = 34/335 (10%)
Query: 327 CIEGQEKVACEEPPFIENGAANLHS--KIYYN---GDKVTYACKSGYLLHGSNE---ITC 378
C GQE C+ P I++G S ++Y+ G +Y C ++ + I C
Sbjct: 15 CANGQEVKPCDFPE-IQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHC 73
Query: 379 NRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKIS- 437
+ W+ C+ C + + + Y ++Y+C Y S
Sbjct: 74 TQDGWSPTVPCLRT---CSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSG 130
Query: 438 --RCEQGKWSSPPVCLEPCTVNVDYMNRNNIE-MKWKYEGKVLHGDLIDFVCKQGYDLSP 494
C Q WS+ P+C++ C + V +R M++K LH D +D+ C GY++S
Sbjct: 131 SITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFK-----LH-DTLDYECYDGYEISY 184
Query: 495 LTPLSELSVQCNR-GEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
S+ C G +P C K C PP I +G S + Y S VEY+C
Sbjct: 185 GNTTG--SIVCGEDGWSHFPTCYNSSEK--CGPPPPISNGDTTSFLLKVYVPQSRVEYQC 240
Query: 554 FDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIE 613
++ L+GS C +G W+ PP C+ PC ++ M KNN+ LK D + + G+ IE
Sbjct: 241 QSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIE 300
Query: 614 FICRGDTYPAELYITGSILRMQ--CDRGQLKYPRC 646
F+C+ Y A S+L Q C G ++YPRC
Sbjct: 301 FMCKLG-YNANT----SVLSFQAVCREGIVEYPRC 330
>gi|239758115 PREDICTED: similar to complement factor H-related 1
isoform 2 [Homo sapiens]
Length = 271
Score = 148 bits (374), Expect = 1e-35
Identities = 80/232 (34%), Positives = 119/232 (51%), Gaps = 16/232 (6%)
Query: 295 GEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS 351
GE+ + CE NF + I C + W+ PKC+ C P F+ENG +
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR-----LCFFP-FVENGHSESSG 101
Query: 352 KIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTLPPEC--VENNENCKHPPVVMNGAVA 408
+ + GD V C +GY L + N I+C W+ PP+C ++ C PP + NG +
Sbjct: 102 QTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDIT 161
Query: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468
L+ YA SSVEY+C Y L G+K C G+WS PP CL PC ++ + M NI +
Sbjct: 162 SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIAL 221
Query: 469 KWKYEGKVL--HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
+W + K+ G+ +FVCK+GY LS + L C G+++YP C ++
Sbjct: 222 RWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 271
Score = 120 bits (302), Expect = 3e-27
Identities = 78/238 (32%), Positives = 109/238 (45%), Gaps = 18/238 (7%)
Query: 417 TGSSVEYRCNEYYLLRGSKIS----RCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKY 472
TG Y C EY + SK C + WS P CL C ++ + E +
Sbjct: 47 TGEVFYYSC-EYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFF--PFVENGHSESSGQT 103
Query: 473 EGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIK 531
L GD + +C GY L +E ++ C RG P C +S G C PP I
Sbjct: 104 H---LEGDTVQIICNTGYRLQN----NENNISCVERGWSTPPKCRSTDSTGKCGPPPPID 156
Query: 532 HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEK 591
+G I S + Y SSVEY+C + + LEG++ C +G W+ PP CL PC +S ME
Sbjct: 157 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMEN 216
Query: 592 NNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649
N+ L+W + ++ GE EF+C+ L LR C G+L+YP C R
Sbjct: 217 YNIALRWTAKQKLYLRTGESAEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 271
Score = 95.1 bits (235), Expect = 2e-19
Identities = 67/221 (30%), Positives = 96/221 (43%), Gaps = 19/221 (8%)
Query: 178 YECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVV 237
Y C + + + C GWS TPKC +L +ENG+ QT+ EGD V
Sbjct: 53 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTV 110
Query: 238 QFFCHENYYLSGSDL-IQCYNFGWYPESPVCEGRRN--RCPPPPLPINSKIQTHS-TTYR 293
Q C+ Y L ++ I C GW P C + +C PPP N I + + Y
Sbjct: 111 QIICNTGYRLQNNENNISCVERGW-STPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYA 169
Query: 294 HGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLH--- 350
V +C+ +++ G+ I C +G+W+EPPKC+ V E +EN L
Sbjct: 170 PASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCL--HPCVISRE--IMENYNIALRWTA 225
Query: 351 -SKIYY-NGDKVTYACKSGYLLHGSN---EITCNRGKWTLP 386
K+Y G+ + CK GY L + TC GK P
Sbjct: 226 KQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYP 266
Score = 87.8 bits (216), Expect = 3e-17
Identities = 71/266 (26%), Positives = 109/266 (40%), Gaps = 36/266 (13%)
Query: 16 GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75
G LY EEK F V G + +YY+ C + + S + T
Sbjct: 31 GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
Query: 76 CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135
CT EGWSP P+C + C P + NG+ + + ++ C +GY+ +E + C
Sbjct: 72 CTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
Query: 136 LSDGWSSQPTCRKEHETCLA---PELYNGNY-STTQKTFKVKDKVQYECATGYYTAGGKK 191
+ GWS+ P CR T P + NG+ S + V+Y+C Y G K+
Sbjct: 130 VERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 189
Query: 192 TEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENY 245
+ C WS PKC S ++EN Y ++ T ++ G+ +F C Y
Sbjct: 190 ---ITCRNGQWSEPPKCLHPCVISREIMEN-YNIALRWTAKQKLYLRTGESAEFVCKRGY 245
Query: 246 YLSG-SDLIQCYNFGWYPESPVCEGR 270
LS S ++ + E P C R
Sbjct: 246 RLSSRSHTLRTTCWDGKLEYPTCAKR 271
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 144 bits (363), Expect = 3e-34
Identities = 142/541 (26%), Positives = 223/541 (41%), Gaps = 52/541 (9%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRCFK-KCTKPDLSNGYISDVKLLYKIQ 111
+ + C GY C + G WS P C +C+ P + G ++ +
Sbjct: 2971 IQYQCFPGYKLHGNSSRR---CLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTD--FDCG 3025
Query: 112 ENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTTQKT 169
+ R C G+K G + + C +DG WSS P C EH +C + + + + +
Sbjct: 3026 KAARIQCFKGFKLLGLSE---ITCEADGQWSSGFPHC--EHTSCGSLPMIPNAFISETSS 3080
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKCSSLRLIENGYFHPV 227
+K ++ + Y C +GY G + ++ C G WS P C L C S + N
Sbjct: 3081 WK-ENVITYSCRSGYVIQG---SSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE 3136
Query: 228 KQTYEEGDVVQFFCHENYYL-SGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPIN-SK 284
TYE V+ C E Y + + +D C G W+PE C ++ CP LP N +
Sbjct: 3137 AHTYESE--VKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK--CP---LPENITH 3189
Query: 285 IQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWTEPPKCIEGQEKVACEEPPFIE 343
I H + V + C + G C+ DG W EPP E V+C +P E
Sbjct: 3190 ILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW-EPPFSDESCSPVSCGKPESPE 3248
Query: 344 NGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVM 403
+G + SK + + Y C+ GY L G+ E C + + C+ P +
Sbjct: 3249 HGFV-VGSKYTFEST-IIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFL 3306
Query: 404 NGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSPPVCLEPCTVNVDYMN 462
NG AD + + TG +V Y CN Y L G + C E G WS P +P V ++
Sbjct: 3307 NGK-AD--IENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVI 3363
Query: 463 RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKG 522
N + E + + C++G+ L + CN E + + K K
Sbjct: 3364 PENALLS---EKEFYVDQNVSIKCREGFLLQ-----GHGIITCNPDET-WTQTSAKCEKI 3414
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTPPLCLEP 581
C P +++ + Y+ G + Y C+ + LEG + CL+ G WT+PP+C
Sbjct: 3415 SCGPPAHVENAIARGVH---YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAV 3471
Query: 582 C 582
C
Sbjct: 3472 C 3472
Score = 140 bits (352), Expect = 5e-33
Identities = 142/542 (26%), Positives = 224/542 (41%), Gaps = 81/542 (14%)
Query: 49 MSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLY 108
+++D C+ YT + E C G +PE NG+ S +Y
Sbjct: 1762 LNVDGSYICSCVPPYTGDGKNCAEPIKCKAPG-NPE-------------NGHSSGE--IY 1805
Query: 109 KIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTT 166
+ + + C GY+ G + CL G W+ P C+ +C P + N
Sbjct: 1806 TVGAEVTFSCQEGYQLMGVTK---ITCLESGEWNHLIPYCKAV--SCGKPAIPE-NGCIE 1859
Query: 167 QKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLTPK-CTKLKCSSLRLIENGYF 224
+ F KV Y C GY AG K E CL WS +P C +KCSS I NG +
Sbjct: 1860 ELAFTFGSKVTYRCNKGYTLAGDK---ESSCLANSSWSHSPPVCEPVKCSSPENINNGKY 1916
Query: 225 HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINS 283
TY + C Y L G +I+C G W P C C PP ++
Sbjct: 1917 ILSGLTYLS--TASYSCDTGYSLQGPSIIECTASGIWDRAPPACH--LVFCGEPPAIKDA 1972
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEPPK-CIEGQEKVACEEPPF 341
I ++ T+R+ V C+ + + G I C DGKW+ + C+ V+C+EPP
Sbjct: 1973 VITGNNFTFRN--TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLA----VSCDEPPI 2026
Query: 342 IENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-----PECVENNEN 395
+++ + +++ GD Y C GY L ++++ CN +GKW P P C+ +
Sbjct: 2027 VDHASPETAHRLF--GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHF-- 2082
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGS-KISRCEQGKWSSPPV----- 449
C+ PP V + A +A GS V ++C E ++L S KI G+W+ P+
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCI 2142
Query: 450 ---CLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
C EP ++ Y + +N G ++ + C +G+ + E C
Sbjct: 2143 PVRCGEPPSIMNGYASGSNYSF----------GAMVAYSCNKGFYIK-----GEKKSTCE 2187
Query: 507 -RGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREA 565
G+ P+ T C PP +++G + +T +E S V Y+C + GS
Sbjct: 2188 ATGQWSSPIPTCHPVS--CGEPPKVENGFLEHTTGRIFE--SEVRYQCNPGYKSVGSPVF 2243
Query: 566 YC 567
C
Sbjct: 2244 VC 2245
Score = 137 bits (346), Expect = 2e-32
Identities = 172/661 (26%), Positives = 270/661 (40%), Gaps = 101/661 (15%)
Query: 30 VENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTE-GWSP-EPRC 87
V NG I YT+ S L + C GY E+ TC + W EP C
Sbjct: 2781 VMNGSIKGSNYTYLS---------TLYYECDPGYVLNG---TERRTCQDDKNWDEDEPIC 2828
Query: 88 FK-KCTKPDLS-NGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQP 144
C+ P +S NG + + Y Q+ + Y C G+ G + CL++G WS
Sbjct: 2829 IPVDCSSPPVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRV---CLANGSWSGAT 2883
Query: 145 TCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS 203
P+L NG T + +V + C GY G K + C + G W
Sbjct: 2884 PDCVPVRCATPPQLANG--VTEGLDYGFMKEVTFHCHEGYILHGAPK---LTCQSDGNWD 2938
Query: 204 LT-PKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WY 261
P C + C + +G+ P ++ G +Q+ C Y L G+ +C + G W
Sbjct: 2939 AEIPLCKPVNCGPPEDLAHGF--PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996
Query: 262 PESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGK 320
SP C RC P + + + T + G+ I+C F++ G +EI CE DG+
Sbjct: 2997 GSSPSC--LPCRCSTPVIEYGT---VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ 3051
Query: 321 WTEP-PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC- 378
W+ P C E +C P I N + S + + +TY+C+SGY++ GS+++ C
Sbjct: 3052 WSSGFPHC----EHTSCGSLPMIPNAFISETSS--WKENVITYSCRSGYVIQGSSDLICT 3105
Query: 379 NRGKWTLP-PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLL-RGSKI 436
+G W+ P P C +C PP V N AVA G +Y S V+ RC E Y + +
Sbjct: 3106 EKGVWSQPYPVC--EPLSCGSPPSVAN-AVATGEAHTYE--SEVKLRCLEGYTMDTDTDT 3160
Query: 437 SRCEQ-GKW------SSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD------LID 483
C++ G+W SP C P N+ ++ ++HGD +
Sbjct: 3161 FTCQKDGRWFPERISCSPKKC--PLPENITHI--------------LVHGDDFSVNRQVS 3204
Query: 484 FVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTY 543
C +GY + +SV G + P S C P +HG ++ S Y
Sbjct: 3205 VSCAEGYTFEGV----NISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGS---KY 3257
Query: 544 ENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNR 603
S++ Y+C + LEG+RE C + + + + C + E L K D +NR
Sbjct: 3258 TFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAI--CKETRCETPLEFLNGKADIENR 3315
Query: 604 ---PHILHGEYIEFICRGDTYPAELYITGSILRMQ----CDRGQLKYPRCIPRQSTLSYQ 656
P++++ + G P+E + T + C P IP + LS +
Sbjct: 3316 TTGPNVVYSCNRGYSLEG---PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEK 3372
Query: 657 E 657
E
Sbjct: 3373 E 3373
Score = 137 bits (345), Expect = 3e-32
Identities = 147/546 (26%), Positives = 226/546 (41%), Gaps = 65/546 (11%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WSPEPRCFK----KCTKP-DLSNGYISDVKLLY 108
+SF C+ G+ + + E C G W+P P + +C +P + NGY S Y
Sbjct: 2108 VSFKCMEGFVLNTSAKIE---CMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSN--Y 2162
Query: 109 KIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNY--S 164
+ Y C G+ G K C + G WSS PTC +C P +
Sbjct: 2163 SFGAMVAYSCNKGFYIKGEKKST---CEATGQWSSPIPTCHPV--SCGEPPKVENGFLEH 2217
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTP-KCTKLKCSSLRLIENGY 223
TT + F+ +V+Y+C GY + G + + S +P C L C I+NG+
Sbjct: 2218 TTGRIFE--SEVRYQCNPGYKSVGSP-VFVCQANRHWHSESPLMCVPLDCGKPPPIQNGF 2274
Query: 224 FHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPES-PVCEGRRNRCPPPPLPI 281
+ +E G VQFFC+E Y L G C G W +S P C +CP PPL
Sbjct: 2275 MKG--ENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKC--MPAKCPEPPLLE 2330
Query: 282 NSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PKCIEGQEKVACEEP 339
N + TT +V C+ + G + ++C +W + P C + V C P
Sbjct: 2331 NQLVLKELTT--EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC----KIVLCTPP 2384
Query: 340 PFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCK 397
P I G S +++ G V Y+C G+ L G++ C G W+ P PECV C
Sbjct: 2385 PLISFGVPIPSSALHF-GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP--VECP 2441
Query: 398 HPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKW-SSPPVCLEPCT 455
P + NG + LA +T Y C + L G+ + C E G W P C
Sbjct: 2442 QPEEIPNGIIDVQGLAYLSTAL---YTCKPGFELVGNTTTLCGENGHWLGGKPTCKA--- 2495
Query: 456 VNVDYMNRNNIEMKWKYEGKVLH-GDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPL 514
++ + I + K+ LH G + + C +G+ L P + ++ +V P
Sbjct: 2496 --IECLKPKEI-LNGKFSYTDLHYGQTVTYSCNRGFRLE--GPSALTCLETGDWDVDAPS 2550
Query: 515 CTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTT 574
C C SP I++G + + Y G+ + Y CF + G C + W++
Sbjct: 2551 CNAIH----CDSPQPIENGFVEGA---DYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSS 2603
Query: 575 P-PLCL 579
P C+
Sbjct: 2604 SIPTCM 2609
Score = 135 bits (340), Expect = 1e-31
Identities = 157/621 (25%), Positives = 246/621 (39%), Gaps = 108/621 (17%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRCFK-KCTKPD-LSNGYISDVKLLYKI 110
+ + C+ G+ R T C +G WS P P C +C +P+ + NG I L Y
Sbjct: 2404 VKYSCVGGFFL---RGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYL- 2459
Query: 111 QENMRYGCASGYKTTGGKDEEVVQCLSDG-W-SSQPTCRKEHETCLAP-ELYNGNYSTTQ 167
Y C G++ G C +G W +PTC+ CL P E+ NG +S T
Sbjct: 2460 -STALYTCKPGFELVGNT---TTLCGENGHWLGGKPTCKAIE--CLKPKEILNGKFSYTD 2513
Query: 168 KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSL-TPKCTKLKCSSLRLIENGYFH 225
+ V Y C G+ G + CL G W + P C + C S + IENG+
Sbjct: 2514 LHYG--QTVTYSCNRGFRLEG---PSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVE 2568
Query: 226 PVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPP--------- 276
+Y G ++ + C + ++G + C GW P C PP
Sbjct: 2569 GADYSY--GAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTK 2626
Query: 277 -----------------------PPLPINSKIQT----------HSTTYRHGEIVHIECE 303
PP + + +T HS+ + +G +V C
Sbjct: 2627 LKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCN 2686
Query: 304 LNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVT 361
+E+ G+ + C EDG W P CI + C+ P ENG G V
Sbjct: 2687 PGYELLGNPVLICQEDGTWNGSAPSCI----SIECDLPTAPENGFLRFTETSM--GSAVQ 2740
Query: 362 YACKSGYLLHGSNEITC-NRGKWT-LPPECVENNENCKHPPVVMNGAVADGILASYATGS 419
Y+CK G++L GS+ C KW+ P C +CK P VMNG++ ++Y S
Sbjct: 2741 YSCKPGHILAGSDLRLCLENRKWSGASPRC--EAISCKKPNPVMNGSIKG---SNYTYLS 2795
Query: 420 SVEYRCNEYYLLRGSKISRCEQGK-W-SSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVL 477
++ Y C+ Y+L G++ C+ K W P+C+ P + ++ N +Y +
Sbjct: 2796 TLYYECDPGYVLNGTERRTCQDDKNWDEDEPICI-PVDCSSPPVSANGQVRGDEYTFQ-- 2852
Query: 478 HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIIS 537
I++ C +G+ L S + + P C C +PP + +GV +
Sbjct: 2853 --KEIEYTCNEGFLLEGAR--SRVCLANGSWSGATPDCVPVR----CATPPQLANGV--T 2902
Query: 538 STVDTYENGSSVEYRCFDHHFLEGSREAYC-LDGMWTTP-PLCLEPCTLSFTEMEKNNLL 595
+D Y V + C + + L G+ + C DG W PLC +P E
Sbjct: 2903 EGLD-YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC-KPVNCGPPED------ 2954
Query: 596 LKWDFDNRPHILHGEYIEFIC 616
L F N +HG +I++ C
Sbjct: 2955 LAHGFPNGFSFIHGGHIQYQC 2975
Score = 129 bits (323), Expect = 1e-29
Identities = 134/519 (25%), Positives = 192/519 (36%), Gaps = 92/519 (17%)
Query: 118 CASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELYNGNYSTTQKTFKVKDKV 176
C G++ G V CL+ G +QP E +C + P L NG +S F V
Sbjct: 1658 CDPGFQLVGNP---VQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADD--FYAGSTV 1712
Query: 177 QYECATGYYTAGGKK----------------------------TEEVECLTYGWSLTPKC 208
Y+C GYY G + +E CL S C
Sbjct: 1713 TYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSC 1772
Query: 209 TK------------LKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY 256
+KC + ENG H + Y G V F C E Y L G I C
Sbjct: 1773 VPPYTGDGKNCAEPIKCKAPGNPENG--HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL 1830
Query: 257 NFG-WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIR 315
G W P C+ C P +P N I+ + T+ G V C + + G E
Sbjct: 1831 ESGEWNHLIPYCKAVS--CGKPAIPENGCIEELAFTF--GSKVTYRCNKGYTLAGDKESS 1886
Query: 316 C-EDGKWTE-PPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGS 373
C + W+ PP C E V C P I NG L Y + +Y+C +GY L G
Sbjct: 1887 CLANSSWSHSPPVC----EPVKCSSPENINNGKYILSGLTYLS--TASYSCDTGYSLQGP 1940
Query: 374 NEITCNR-GKWT-LPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLL 431
+ I C G W PP C + C PP + + + ++ ++V Y C E Y L
Sbjct: 1941 SIIECTASGIWDRAPPAC--HLVFCGEPPAIKDAVITGN---NFTFRNTVTYTCKEGYTL 1995
Query: 432 RGSKISRC-EQGKWS-SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQG 489
G C GKWS S CL ++ + E + L GD+ + C G
Sbjct: 1996 AGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR-----LFGDIAFYYCSDG 2050
Query: 490 YDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGM-------CTSPPLIKHGVIISSTVDT 542
Y L+ + L CN P E + M C PP + + ++ S +
Sbjct: 2051 YSLADNSQLL-----CNAQGKWVP----PEGQDMPRCIAHFCEKPPSVSYSILESVSKAK 2101
Query: 543 YENGSSVEYRCFDHHFLEGSREAYCL-DGMWTTPPLCLE 580
+ GS V ++C + L S + C+ G W P+ ++
Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQ 2140
Score = 117 bits (293), Expect = 3e-26
Identities = 124/453 (27%), Positives = 178/453 (39%), Gaps = 59/453 (13%)
Query: 26 GFPHVENGRIAQYYYTFKSFYFPMSIDKK--LSFFCLAGYTTESGRQEEQTTCTTEG-WS 82
GFPH E+ +F S K+ +++ C +GY + CT +G WS
Sbjct: 3055 GFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGS---SDLICTEKGVWS 3111
Query: 83 -PEPRCFK-KC-TKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
P P C C + P ++N + Y+ + +R C GY T D + C DG
Sbjct: 3112 QPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLR--CLEGY--TMDTDTDTFTCQKDG 3167
Query: 140 WSSQPTCRKEHETCLAPE-----LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ C PE L +G+ F V +V CA GY G +
Sbjct: 3168 RWFPERISCSPKKCPLPENITHILVHGD------DFSVNRQVSVSCAEGYTFEGVNISV- 3220
Query: 195 VECLTYGWSLTP----KCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
C G P C+ + C E+G+ K T+E + Q C Y L G+
Sbjct: 3221 --CQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQ--CEPGYELEGN 3276
Query: 251 DLIQCY-NFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIH 309
C N W +C + RC P +N K + T G V C + +
Sbjct: 3277 RERVCQENRQWSGGVAIC--KETRCETPLEFLNGKADIENRTT--GPNVVYSCNRGYSLE 3332
Query: 310 GSAEIRC-EDGKWTEP-PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSG 367
G +E C E+G W+ P P C V PF+ A L K +Y V+ C+ G
Sbjct: 3333 GPSEAHCTENGTWSHPVPLCKPNPCPV-----PFVIPENALLSEKEFYVDQNVSIKCREG 3387
Query: 368 YLLHGSNEITCNRGK-WTLPPECVENNENCKH----PPVVMNGAVADGILASYATGSSVE 422
+LL G ITCN + WT + + C+ PP + A+A G+ Y G +
Sbjct: 3388 FLLQGHGIITCNPDETWT------QTSAKCEKISCGPPAHVENAIARGV--HYQYGDMIT 3439
Query: 423 YRCNEYYLLRGSKISRC-EQGKWSSPPVCLEPC 454
Y C Y+L G S C E G W+SPP+C C
Sbjct: 3440 YSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472
Score = 113 bits (283), Expect = 5e-25
Identities = 128/436 (29%), Positives = 175/436 (40%), Gaps = 95/436 (21%)
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKCSSLRLIENG 222
T + K KV C G+ G CL G W+ P C ++ C +ENG
Sbjct: 1643 TASEDLKPGSKVNLFCDPGFQLVGNPVQY---CLNQGQWTQPLPHCERISCGVPPPLENG 1699
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPI 281
FH Y G V + C+ YYL G + C + G W SP C L +
Sbjct: 1700 -FHSADDFYA-GSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC-----------LDV 1746
Query: 282 NSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWT---EPPKCIEGQ---EKVA 335
+ EC + + A DG + PP +G+ E +
Sbjct: 1747 D------------------ECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIK 1788
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENN 393
C+ P ENG ++ +IY G +VT++C+ GY L G +ITC G+W L P C
Sbjct: 1789 CKAPGNPENGHSS--GEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC--KA 1844
Query: 394 ENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS-SPPVCL 451
+C P + NG + + ++ GS V YRCN+ Y L G K S C WS SPPVC
Sbjct: 1845 VSCGKPAIPENGCIEE---LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVC- 1900
Query: 452 EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG-EV 510
EP V + NI GK Y LS LT LS S C+ G +
Sbjct: 1901 EP----VKCSSPENIN-----NGK--------------YILSGLTYLSTASYSCDTGYSL 1937
Query: 511 KYPLCTRKESKGM------------CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
+ P + G+ C PP IK VI + T+ N +V Y C + +
Sbjct: 1938 QGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNF-TFRN--TVTYTCKEGYT 1994
Query: 559 LEGSREAYCL-DGMWT 573
L G CL DG W+
Sbjct: 1995 LAGLDTIECLADGKWS 2010
Score = 42.7 bits (99), Expect = 0.001
Identities = 55/206 (26%), Positives = 76/206 (36%), Gaps = 18/206 (8%)
Query: 126 GGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNY--STTQKTFKVKDKVQYECATG 183
G E C +S TC H L P NG + +T F V+ C G
Sbjct: 353 GSTSPEDCVCREGYRASGQTCELVHCPALKPP-ENGYFIQNTCNNHFNAACGVR--CHPG 409
Query: 184 YYTAGGKKTEEVECLTYG-WSLTPK-CTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFC 241
+ G + + CL G WS + C C LR ++G+ + C
Sbjct: 410 FDLVG---SSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVAC 466
Query: 242 HENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPPLPINSKIQTHS---TTYRHGEI 297
E Y L GSD + C N W P C R C +P + I H+ + G I
Sbjct: 467 DEGYRLEGSDKLTCQGNSQWDGPEPRCVER--HCSTFQMPKDVIISPHNCGKQPAKFGTI 524
Query: 298 VHIECELNFEIHGSAE-IRC-EDGKW 321
++ C F + G E +RC GKW
Sbjct: 525 CYVSCRQGFILSGVKEMLRCTTSGKW 550
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/200 (25%), Positives = 80/200 (40%), Gaps = 21/200 (10%)
Query: 262 PESPVC-EGRRN--------RCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSA 312
PE VC EG R CP P N ++ + C F++ GS+
Sbjct: 357 PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSS 416
Query: 313 EIRC-EDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLH 371
I C +G W+ + +P ++G + ++ AC GY L
Sbjct: 417 IILCLPNGLWSGSESYCRVRTCPHLRQP---KHGHISCSTREMLYKTTCLVACDEGYRLE 473
Query: 372 GSNEITC-NRGKWTLP-PECVENNENCKHPP--VVMNGAVADGILASYATGSSVEYRCNE 427
GS+++TC +W P P CVE + + P V+++ A + T V C +
Sbjct: 474 GSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVS--CRQ 531
Query: 428 YYLLRGSK-ISRC-EQGKWS 445
++L G K + RC GKW+
Sbjct: 532 GFILSGVKEMLRCTTSGKWN 551
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 125 bits (315), Expect = 1e-28
Identities = 119/408 (29%), Positives = 173/408 (42%), Gaps = 55/408 (13%)
Query: 82 SPEPRCFK--KCTKPDLSNGY-ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSD 138
SP PRC KCT P++ N + + + + E +R+ C G+ G VQC ++
Sbjct: 2030 SPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS---HTVQCQTN 2086
Query: 139 G-WSSQ-PTCRKEHETCLAPELYNGNYSTT-QKTFKVKDKVQYECATGYYTAGGKKTEEV 195
G W + P C + + PE+ +G ++ + Q F +V Y C Y G +
Sbjct: 2087 GRWGPKLPHCSRVCQP--PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAAS---L 2141
Query: 196 ECLTYG-WSL-TPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSD 251
C G WS P+CT C +L P+ + G V F C E + L G
Sbjct: 2142 HCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRS 2199
Query: 252 LIQCYNFG----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTT----YRHGEIVHIECE 303
C G W PVCE + CP PP +N + H+ T +G+ + C+
Sbjct: 2200 ASHCVLAGMKALWNSSVPVCE--QIFCPNPPAILNGR---HTGTPFGDIPYGKEISYACD 2254
Query: 304 ------LNFEIHGSAEIRCE-----DGKWTEPPKCIEGQEKVACEEPPFIENGA-ANLHS 351
+ F + G + IRC +G W+ P E AC PP I+NG H
Sbjct: 2255 THPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHV 2314
Query: 352 KIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENNENCKHPPVVMNGAVAD 409
+Y G ++Y C GYLL G I C ++G W+ L C E NC P + MNG +
Sbjct: 2315 SLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKE--VNCSFP-LFMNGISKE 2371
Query: 410 GILAS-YATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSPPVCLEPCT 455
+ Y G V +C + Y L GS S+C+ +W P L CT
Sbjct: 2372 LEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPP---LAKCT 2416
Score = 124 bits (312), Expect = 2e-28
Identities = 145/582 (24%), Positives = 224/582 (38%), Gaps = 99/582 (17%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G + + Q L
Sbjct: 1125 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQAL 1183
Query: 137 SDGWSSQPTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ P+C + C P L+ + F +V Y C GY G
Sbjct: 1184 NKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---AAS 1237
Query: 195 VECLTYG-WS-LTPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
+ C G WS P C C +L+ PV + G V F C E + L GS
Sbjct: 1238 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGS 1295
Query: 251 DLIQCYNFG----WYPESPVCEGRRNRCPPPP-LPINSKIQTHSTTYRHGEIVHIECE-- 303
C G W PVCE + CP PP +P + G+ V+ C+
Sbjct: 1296 SASYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPH 1353
Query: 304 ----LNFEIHGSAEIRCE-----DGKWTEP-PKC-IEGQEKVACEEPP--FIENGAANLH 350
+F++ G + IRC +G W+ P P+C I G C+ P +
Sbjct: 1354 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH----CQAPDHFLFAKLKTQTN 1409
Query: 351 SKIYYNGDKVTYACKSGYLLHGSN-EITCNRGKWTLPPECVENNENCKHPPVVMNGAVAD 409
+ + G + Y C+ Y +G ITC P+ V ++CK PP +NG V
Sbjct: 1410 ASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-- 1465
Query: 410 GILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKWSS-PPVC------LEPCTVNV 458
++ GS + Y C + L G + C WS+ PP+C L P N
Sbjct: 1466 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANG 1525
Query: 459 DYM--NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLC 515
D++ NR N +G ++ + C G + L E S+ C + + +
Sbjct: 1526 DFISTNRENFH----------YGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
Query: 516 TRKESK----GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC--LD 569
+ + CT PP +++G+++S + VE+RC ++G R C L+
Sbjct: 1576 SGPAPQCIIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN 1634
Query: 570 GMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEY 611
P C C P ILHGE+
Sbjct: 1635 KWEPELPSCSRVC------------------QPPPEILHGEH 1658
Score = 124 bits (311), Expect = 3e-28
Identities = 135/536 (25%), Positives = 212/536 (39%), Gaps = 79/536 (14%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G + + Q L
Sbjct: 225 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQAL 283
Query: 137 SDGWSSQPTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ P+C + C P L+ + F +V Y C GY G
Sbjct: 284 NKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---AAS 337
Query: 195 VECLTYG-WS-LTPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
+ C G WS P C C +L+ PV + G V F C E + L GS
Sbjct: 338 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGS 395
Query: 251 DLIQCYNFG----WYPESPVCEGRRNRCPPPP-LPINSKIQTHSTTYRHGEIVHIECE-- 303
C G W PVCE + CP PP +P + G+ V+ C+
Sbjct: 396 SASYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPH 453
Query: 304 ----LNFEIHGSAEIRCE-----DGKWTEP-PKC-IEGQEKVACEEPP--FIENGAANLH 350
+F++ G + IRC +G W+ P P+C I G C+ P +
Sbjct: 454 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH----CQAPDHFLFAKLKTQTN 509
Query: 351 SKIYYNGDKVTYACKSGYLLHGSN-EITCNRGKWTLPPECVENNENCKHPPVVMNGAVAD 409
+ + G + Y C+ Y +G ITC P+ V ++CK PP +NG V
Sbjct: 510 ASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-- 565
Query: 410 GILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKWSS-PPVC------LEPCTVNV 458
++ GS + Y C + L G + C WS+ PP+C L P N
Sbjct: 566 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANG 625
Query: 459 DYM--NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLC 515
D++ NR N +G ++ + C G + L E S+ C + + +
Sbjct: 626 DFISTNRENFH----------YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 516 TRKESK----GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
+ + CT PP +++G+++S + VE+RC ++G R C
Sbjct: 676 SGPAPQCIIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 730
Score = 124 bits (311), Expect = 3e-28
Identities = 135/536 (25%), Positives = 212/536 (39%), Gaps = 79/536 (14%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G + + Q L
Sbjct: 675 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQAL 733
Query: 137 SDGWSSQPTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ P+C + C P L+ + F +V Y C GY G
Sbjct: 734 NKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---AAS 787
Query: 195 VECLTYG-WS-LTPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
+ C G WS P C C +L+ PV + G V F C E + L GS
Sbjct: 788 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGS 845
Query: 251 DLIQCYNFG----WYPESPVCEGRRNRCPPPP-LPINSKIQTHSTTYRHGEIVHIECE-- 303
C G W PVCE + CP PP +P + G+ V+ C+
Sbjct: 846 SASYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPH 903
Query: 304 ----LNFEIHGSAEIRCE-----DGKWTEP-PKC-IEGQEKVACEEPP--FIENGAANLH 350
+F++ G + IRC +G W+ P P+C I G C+ P +
Sbjct: 904 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH----CQAPDHFLFAKLKTQTN 959
Query: 351 SKIYYNGDKVTYACKSGYLLHGSN-EITCNRGKWTLPPECVENNENCKHPPVVMNGAVAD 409
+ + G + Y C+ Y +G ITC P+ V ++CK PP +NG V
Sbjct: 960 ASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-- 1015
Query: 410 GILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKWSS-PPVC------LEPCTVNV 458
++ GS + Y C + L G + C WS+ PP+C L P N
Sbjct: 1016 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANG 1075
Query: 459 DYM--NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLC 515
D++ NR N +G ++ + C G + L E S+ C + + +
Sbjct: 1076 DFISTNRENFH----------YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 516 TRKESK----GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
+ + CT PP +++G+++S + VE+RC ++G R C
Sbjct: 1126 SGPAPQCIIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180
Score = 119 bits (298), Expect = 9e-27
Identities = 154/606 (25%), Positives = 236/606 (38%), Gaps = 83/606 (13%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
C P+VENG + + S+++ + F C G+ + R+ + W PE
Sbjct: 1138 CTPPNVENGILVSDNRSL------FSLNEVVEFRCQPGFVMKGPRRVKCQALNK--WEPE 1189
Query: 85 -PRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-W 140
P C + C P L K + + + Y C GY G ++C G W
Sbjct: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS---MRCTPQGDW 1246
Query: 141 S-SQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLT 199
S + PTC + +L NG ++ KV + C G+ G + C+
Sbjct: 1247 SPAAPTCEVKSCDDFMGQLLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASY---CVL 1302
Query: 200 YG----W-SLTPKCTKLKCSSLRLIENGYFHPVK--QTYEEGDVVQFFCHEN------YY 246
G W S P C ++ C S +I NG H K + + G V + C + +
Sbjct: 1303 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 1361
Query: 247 LSGSDLIQCY-----NFGWYPESPVCEGRRNRCPPPP--LPINSKIQTHSTTYRHGEIVH 299
L G I+C N W +P C G C P L K QT+++ + G +
Sbjct: 1362 LIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 1420
Query: 300 IECELNFEIHGSA-EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGD 358
EC E +G I C D PK + ++ +C+ PP NG ++ + I G
Sbjct: 1421 YECRP--EYYGRPFSITCLDNLVWSSPKDV--CKRKSCKTPPDPVNGMVHVITDIQV-GS 1475
Query: 359 KVTYACKSGYLLHGSNEITC----NRGKW-TLPPECVENNENCKHPPVVMNGAVADGILA 413
++ Y+C +G+ L G + C N W T PP C C PP + NG
Sbjct: 1476 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC--QRIPCGLPPTIANGDFISTNRE 1533
Query: 414 SYATGSSVEYRCN------EYYLLRGSKISRC-----EQGKWSSP-PVCLEP--CTVNVD 459
++ GS V YRCN + + L G C + G WS P P C+ P CT
Sbjct: 1534 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP-- 1591
Query: 460 YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKE 519
N N + ++++F C+ G+ + P N+ E + P C+R
Sbjct: 1592 --NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG--PRRVKCQALNKWEPELPSCSR-- 1645
Query: 520 SKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT--TPP 576
+C PP I HG S D + G V Y C + L G+ +C G W+ P
Sbjct: 1646 ---VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPR 1702
Query: 577 LCLEPC 582
++ C
Sbjct: 1703 CAVKSC 1708
Score = 115 bits (288), Expect = 1e-25
Identities = 118/457 (25%), Positives = 187/457 (40%), Gaps = 70/457 (15%)
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENG 222
T + F + + YEC GY + + CL W+ +C + C + NG
Sbjct: 58 TDEFEFPIGTYLNYECRPGY----SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNG 113
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPP 278
H +K + G +++ C + Y L GS C G W E+P+C+ R C PP
Sbjct: 114 MVHVIKGI-QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD--RIPCGLPP 170
Query: 279 LPINSK-IQTHSTTYRHGEIVHIECELN------FEIHGSAEIRCED-----GKWTEP-P 325
N I T+ + +G +V C FE+ G I C G W+ P P
Sbjct: 171 TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 230
Query: 326 KCIEGQEKVACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHGSNEITCNR-GKW 383
+CI + PP +ENG ++ ++ + V + C+ G+++ G + C KW
Sbjct: 231 QCIIPNKCT----PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 286
Query: 384 TLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQG 442
PE + C+ PP V++ +++ G V Y C Y LRG+ RC QG
Sbjct: 287 E--PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
Query: 443 KWS-SPPVC-LEPCTVNVDYMNRNNIEMKWKYEGKVLH------GDLIDFVCKQGYDL-S 493
WS + P C ++ C D+M + G+VL G +DFVC +G+ L
Sbjct: 345 DWSPAAPTCEVKSCD---DFMGQ-------LLNGRVLFPVNLQLGAKVDFVCDEGFQLKG 394
Query: 494 PLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
L+ + P+C + C SPP+I +G ++ + G +V Y C
Sbjct: 395 SSASYCVLAGMESLWNSSVPVC----EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 450
Query: 554 FDH------HFLEGSREAYCL-----DGMWTTP-PLC 578
H L G C +G+W++P P C
Sbjct: 451 DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
Score = 115 bits (287), Expect = 2e-25
Identities = 129/502 (25%), Positives = 201/502 (40%), Gaps = 82/502 (16%)
Query: 130 EEVVQCLSDG-----WSSQ-PTCRKEHETCLAPELY---NGNYSTTQKTFKVKDKVQYEC 180
E ++C SD WSS P C C AP+ + T F + ++YEC
Sbjct: 465 ESTIRCTSDPQGNGVWSSPAPRCGILGH-CQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 181 ATGYYTAGGKKTEEVECL-TYGWSLTPK--CTKLKCSSLRLIENGYFHPVKQTYEEGDVV 237
YY + + CL WS +PK C + C + NG H + + G +
Sbjct: 524 RPEYYG----RPFSITCLDNLVWS-SPKDVCKRKSCKTPPDPVNGMVHVITDI-QVGSRI 577
Query: 238 QFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINSK-IQTHSTTY 292
+ C + L G +C G W + P+C+ R C PP N I T+ +
Sbjct: 578 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ--RIPCGLPPTIANGDFISTNRENF 635
Query: 293 RHGEIVHIECELN------FEIHGSAEIRCED-----GKWTEP-PKCIEGQEKVACEEPP 340
+G +V C FE+ G I C G W+ P P+CI + PP
Sbjct: 636 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT----PP 691
Query: 341 FIENGAANLHSKIYYN-GDKVTYACKSGYLLHGSNEITCNR-GKWTLPPECVENNENCKH 398
+ENG ++ ++ + V + C+ G+++ G + C KW PE + C+
Sbjct: 692 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE--PELPSCSRVCQP 749
Query: 399 PPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS-SPPVC-LEPCT 455
PP V++ +++ G V Y C Y LRG+ RC QG WS + P C ++ C
Sbjct: 750 PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD 809
Query: 456 VNVDYMNRNNIEMKWKYEGKVLH------GDLIDFVCKQGYDL-SPLTPLSELSVQCNRG 508
D+M + G+VL G +DFVC +G+ L L+ +
Sbjct: 810 ---DFMGQ-------LLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLW 859
Query: 509 EVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDH------HFLEGS 562
P+C + C SPP+I +G ++ + G +V Y C H L G
Sbjct: 860 NSSVPVC----EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
Query: 563 REAYCL-----DGMWTTP-PLC 578
C +G+W++P P C
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRC 937
Score = 110 bits (274), Expect = 5e-24
Identities = 146/594 (24%), Positives = 234/594 (39%), Gaps = 81/594 (13%)
Query: 82 SPEPRCFKK-----CTKPD---LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVV 133
SP PRC C P+ ++ I + + ++ Y C GY GK +
Sbjct: 1832 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSI- 1887
Query: 134 QCLSD-GWSS-QPTCRKEHETC-LAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGK 190
CL + WSS + CR++ +C PE +NG T + V Y C G+ G
Sbjct: 1888 SCLENLVWSSVEDNCRRK--SCGPPPEPFNGMVHINTDT-QFGSTVNYSCNEGFRLIGSP 1944
Query: 191 KTEEVECLTYGWSLT-----PKCTKLKCSSLRLIENGYFHPVKQT-YEEGDVVQFFCHEN 244
T CL G ++T P C + C I NG F+ +T + G VV + CH
Sbjct: 1945 STT---CLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG 2001
Query: 245 ------YYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYR 293
+ L G I C + W P C N+C P + ++ + + +
Sbjct: 2002 PDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIST-NKCTAPEVENAIRVPGNRSFFT 2060
Query: 294 HGEIVHIECELNFEIHGSAEIRCE-DGKW-TEPPKCIEGQEKVACEEPPFIENGAANL-H 350
EI+ C+ F + GS ++C+ +G+W + P C C+ PP I +G L H
Sbjct: 2061 LTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR-----VCQPPPEILHGEHTLSH 2115
Query: 351 SKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHPPVVMNGAVA 408
+ G +V Y+C+ Y L G+ + C +G W+ P C ++C G +
Sbjct: 2116 QDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTV--KSCDD----FLGQLP 2169
Query: 409 DG---ILASYATGSSVEYRCNEYYLLRGSKISRCE----QGKW-SSPPVCLEP-CTVNVD 459
G + + G+ V + C+E + L+G S C + W SS PVC + C
Sbjct: 2170 HGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPA 2229
Query: 460 YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLS-PLTPLSELSVQCNRG-------EVK 511
+N + + G + +G I + C D + E S++C
Sbjct: 2230 ILNGRHTGTPF---GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSP 2286
Query: 512 YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-G 570
P C C PP I++G I V Y G ++ Y C + L G +C D G
Sbjct: 2287 APRC-ELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 2345
Query: 571 MWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAE 624
+W+ + SF + N + + + H +G+Y+ C D Y E
Sbjct: 2346 IWSQLDHYCKEVNCSF-PLFMNGISKELEMKKVYH--YGDYVTLKCE-DGYTLE 2395
Score = 102 bits (254), Expect = 1e-21
Identities = 123/472 (26%), Positives = 188/472 (39%), Gaps = 76/472 (16%)
Query: 74 TTCTTEG----WSPE-PRC-FKKCTKPD-LSNG-YISDVKLLYKIQENMRYGCASG---- 121
TTC G W + P C C P +SNG + S+ + + + Y C +G
Sbjct: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005
Query: 122 --YKTTGGKDEEVVQCLSDG-----WSSQPTCRKEHETCLAPELYNG-NYSTTQKTFKVK 173
++ G E + C S WSS P C APE+ N + F +
Sbjct: 2006 QLFELVG---ERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLT 2062
Query: 174 DKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQTY 231
+ +++ C G+ G + V+C T G W P C+++ ++ + + +
Sbjct: 2063 EIIRFRCQPGFVMVG---SHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNF 2119
Query: 232 EEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRR-----NRCPPPP--LPINS 283
G V + C +Y L G+ + C G W PE+P C + + P LP+N
Sbjct: 2120 SPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL 2179
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWTEP-PKCIEGQEKVACEE 338
++ G V C+ F + G + C W P C E++ C
Sbjct: 2180 QL---------GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC----EQIFCPN 2226
Query: 339 PPFIENG--AANLHSKIYYNGDKVTYACKSG------YLLHGSNEITCN-----RGKWTL 385
PP I NG I Y G +++YAC + + L G + I C G W+
Sbjct: 2227 PPAILNGRHTGTPFGDIPY-GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS 2285
Query: 386 P-PEC-VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQG 442
P P C + C HPP + NG G ++ Y G ++ Y C+ YLL G C +QG
Sbjct: 2286 PAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 2345
Query: 443 KWSS-PPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLH-GDLIDFVCKQGYDL 492
WS C E +MN + E++ K KV H GD + C+ GY L
Sbjct: 2346 IWSQLDHYCKEVNCSFPLFMNGISKELEMK---KVYHYGDYVTLKCEDGYTL 2394
Score = 100 bits (250), Expect = 3e-21
Identities = 136/596 (22%), Positives = 222/596 (37%), Gaps = 102/596 (17%)
Query: 47 FPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSP-EPRCFKKCT--KPDLSNGYISD 103
F + L++ C GY G+ + WS E C +K P+ NG +
Sbjct: 1864 FEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVH- 1919
Query: 104 VKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG----WSSQ-PTCRKEHETCLAPE- 157
+ + + Y C G++ G CL G W + P C E +C P
Sbjct: 1920 INTDTQFGSTVNYSCNEGFRLIGSPS---TTCLVSGNNVTWDKKAPIC--EIISCEPPPT 1974
Query: 158 LYNGN-YSTTQKTFKVKDKVQYECATG------YYTAGGKK---TEEVECLTYGWSLTPK 207
+ NG+ YS + +F V Y+C TG + G + T + + + S P+
Sbjct: 1975 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 2034
Query: 208 CTKLKCSSLRLIENGYFHPVKQTYEE-GDVVQFFCHENYYLSGSDLIQCYNFG-WYPESP 265
C + +EN P +++ ++++F C + + GS +QC G W P+ P
Sbjct: 2035 CISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLP 2094
Query: 266 VCEGRRNRCPPPPLPINSK-IQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT- 322
C C PPP ++ + +H + G+ V CE ++++ G+A + C G W+
Sbjct: 2095 HCS---RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 2151
Query: 323 EPPKC-IEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC--- 378
E P+C ++ + + P +G L + G KV++ C G+ L G + C
Sbjct: 2152 EAPRCTVKSCDDFLGQLP----HGRVLLPLNLQL-GAKVSFVCDEGFRLKGRSASHCVLA 2206
Query: 379 -NRGKWTLP-PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEY------YL 430
+ W P C + C +PP ++NG G + Y C+ + +
Sbjct: 2207 GMKALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFN 2264
Query: 431 LRGSKISRCEQ-----GKWSSPP---------VCLEPCTVNVDYMNRNNIEMKWKYEGKV 476
L G RC G WSSP C P + + ++ +
Sbjct: 2265 LIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL-------Y 2317
Query: 477 LHGDLIDFVCKQGYDL--------SPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPP 528
L G I ++C GY L + S+L C +PL SK +
Sbjct: 2318 LPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKEL----- 2372
Query: 529 LIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC-LDGMWTTPPLCLEPCT 583
Y G V +C D + LEGS + C D W P L CT
Sbjct: 2373 ---------EMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPP---LAKCT 2416
Score = 96.7 bits (239), Expect = 6e-20
Identities = 126/542 (23%), Positives = 210/542 (38%), Gaps = 76/542 (14%)
Query: 82 SPEPRC--FKKCTKPDLSNGYISDVKLL-------YKIQENMRYGCASGYKTTGGKDEEV 132
SP PRC C PD + KL + I +++Y C Y G+ +
Sbjct: 932 SPAPRCGILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSI 984
Query: 133 VQCLSD-GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKK 191
CL + WSS K P+ NG +V ++ Y C TG+ G
Sbjct: 985 T-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSS 1042
Query: 192 TEEVECLTYG----WSLTPK-CTKLKCSSLRLIENGYFHPV-KQTYEEGDVVQFFCHEN- 244
E C+ G WS P C ++ C I NG F ++ + G VV + C+
Sbjct: 1043 AE---CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGS 1099
Query: 245 -----YYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH 294
+ L G I C + W +P C N+C PP + + + + +
Sbjct: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTPPNVENGILVSDNRSLFSL 1158
Query: 295 GEIVHIECELNFEIHGSAEIRCED-GKW-TEPPKCIEGQEKVACEEPPFIENGAANLHSK 352
E+V C+ F + G ++C+ KW E P C C+ PP + + K
Sbjct: 1159 NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR-----VCQPPPDVLHAERTQRDK 1213
Query: 353 IYYN-GDKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNENCKHPPVVMNGAVADG 410
++ G +V Y+C+ GY L G+ + C +G W+ E ++NG V
Sbjct: 1214 DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 1273
Query: 411 ILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKW-SSPPVCLEPCTVNVDYMNRNN 465
+ + G+ V++ C+E + L+GS S C + W SS PVC + +
Sbjct: 1274 V--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ------IFCPSPP 1325
Query: 466 IEMKWKYEGKVLH----GDLIDFVCKQGYDL-SPLTPLSELSVQC-----NRGEVKYPLC 515
+ ++ GK L G +++ C D + + E +++C G P
Sbjct: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSP-A 1384
Query: 516 TRKESKGMCTSPPLIKHGVIISST-VDTYENGSSVEYRCFDHHFLEGSREAYCLDGM-WT 573
R G C +P + + T + G+S++Y C ++ CLD + W+
Sbjct: 1385 PRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY-GRPFSITCLDNLVWS 1443
Query: 574 TP 575
+P
Sbjct: 1444 SP 1445
Score = 92.8 bits (229), Expect = 9e-19
Identities = 125/528 (23%), Positives = 200/528 (37%), Gaps = 79/528 (14%)
Query: 82 SPEPRC--FKKCTKPDLSNGYISDVKLL-------YKIQENMRYGCASGYKTTGGKDEEV 132
SP PRC C PD + KL + I +++Y C Y G+ +
Sbjct: 1382 SPAPRCGILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSI 1434
Query: 133 VQCLSD-GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKK 191
CL + WSS K P+ NG +V ++ Y C TG+ G
Sbjct: 1435 T-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSS 1492
Query: 192 TEEVECLTYG----WSLTPK-CTKLKCSSLRLIENGYFHPV-KQTYEEGDVVQFFCH--- 242
E C+ G WS P C ++ C I NG F ++ + G VV + C+
Sbjct: 1493 AE---CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGS 1549
Query: 243 ---ENYYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH 294
+ + L G I C + W +P C N+C PP + + + + +
Sbjct: 1550 RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTPPNVENGILVSDNRSLFSL 1608
Query: 295 GEIVHIECELNFEIHGSAEIRCED-GKWT-EPPKCIEGQEKVACEEPPFIENGAAN-LHS 351
E+V C+ F + G ++C+ KW E P C C+ PP I +G H
Sbjct: 1609 NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR-----VCQPPPEILHGEHTPSHQ 1663
Query: 352 KIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHPPVVMNGAVAD 409
+ G +V Y+C+ GY L G+ + C +G W+ P C ++C G +
Sbjct: 1664 DNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAV--KSCDD----FLGQLPH 1717
Query: 410 GILA---SYATGSSVEYRCNEYYLLRGSKISRC----EQGKW-SSPPVCLEPCTVNVDYM 461
G + + G+ V + C+E + L+GS +S C + W +S PVC N +
Sbjct: 1718 GRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAI 1777
Query: 462 NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLS-PLTPLSELSVQCNRG-------EVKYP 513
N G + +G I + C D + E +++C P
Sbjct: 1778 --LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1835
Query: 514 LCTRKESKGMCTSP---PLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
C G C +P P + I+ + G+S+ Y C +F
Sbjct: 1836 RCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLNYECRPGYF 1881
Score = 65.5 bits (158), Expect = 2e-10
Identities = 95/391 (24%), Positives = 146/391 (37%), Gaps = 49/391 (12%)
Query: 25 CGFPHVENG-RIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS 82
C P VEN R+ +SF+ ++ + + F C G+ + C T G W
Sbjct: 2041 CTAPEVENAIRVPGN----RSFF---TLTEIIRFRCQPGFVMVGSHTVQ---CQTNGRWG 2090
Query: 83 PE-PRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
P+ P C + C P L + + + + + Y C Y G + C G
Sbjct: 2091 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAAS---LHCTPQG 2147
Query: 140 -WSSQ-PTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVEC 197
WS + P C + +L +G ++ KV + C G+ G + C
Sbjct: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRV-LLPLNLQLGAKVSFVCDEGFRLKGRSASH---C 2203
Query: 198 LTYG----W-SLTPKCTKLKCSSLRLIENGYFHPVK-QTYEEGDVVQFFCHEN------Y 245
+ G W S P C ++ C + I NG G + + C + +
Sbjct: 2204 VLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTF 2263
Query: 246 YLSGSDLIQCY-----NFGWYPESPVCE-GRRNRCPPPPLPINSK-IQTHSTTYRHGEIV 298
L G I+C N W +P CE CP PP N I H + Y G +
Sbjct: 2264 NLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTI 2323
Query: 299 HIECELNFEIHGSAEIRCED-GKWTEPPKCIEGQEKVACEEPPFIENGAANLH-SKIYYN 356
C+ + + G I C D G W++ + +V C P F+ + L K+Y+
Sbjct: 2324 SYICDPGYLLVGKGFIFCTDQGIWSQLDHYCK---EVNCSFPLFMNGISKELEMKKVYHY 2380
Query: 357 GDKVTYACKSGYLLHGSNEITCNR-GKWTLP 386
GD VT C+ GY L GS C +W P
Sbjct: 2381 GDYVTLKCEDGYTLEGSPWSQCQADDRWDPP 2411
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 125 bits (315), Expect = 1e-28
Identities = 119/408 (29%), Positives = 173/408 (42%), Gaps = 55/408 (13%)
Query: 82 SPEPRCFK--KCTKPDLSNGY-ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSD 138
SP PRC KCT P++ N + + + + E +R+ C G+ G VQC ++
Sbjct: 1580 SPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS---HTVQCQTN 1636
Query: 139 G-WSSQ-PTCRKEHETCLAPELYNGNYSTT-QKTFKVKDKVQYECATGYYTAGGKKTEEV 195
G W + P C + + PE+ +G ++ + Q F +V Y C Y G +
Sbjct: 1637 GRWGPKLPHCSRVCQP--PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAAS---L 1691
Query: 196 ECLTYG-WSL-TPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSD 251
C G WS P+CT C +L P+ + G V F C E + L G
Sbjct: 1692 HCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRS 1749
Query: 252 LIQCYNFG----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTT----YRHGEIVHIECE 303
C G W PVCE + CP PP +N + H+ T +G+ + C+
Sbjct: 1750 ASHCVLAGMKALWNSSVPVCE--QIFCPNPPAILNGR---HTGTPFGDIPYGKEISYACD 1804
Query: 304 ------LNFEIHGSAEIRCE-----DGKWTEPPKCIEGQEKVACEEPPFIENGA-ANLHS 351
+ F + G + IRC +G W+ P E AC PP I+NG H
Sbjct: 1805 THPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHV 1864
Query: 352 KIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENNENCKHPPVVMNGAVAD 409
+Y G ++Y C GYLL G I C ++G W+ L C E NC P + MNG +
Sbjct: 1865 SLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKE--VNCSFP-LFMNGISKE 1921
Query: 410 GILAS-YATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSPPVCLEPCT 455
+ Y G V +C + Y L GS S+C+ +W P L CT
Sbjct: 1922 LEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPP---LAKCT 1966
Score = 124 bits (312), Expect = 2e-28
Identities = 145/582 (24%), Positives = 224/582 (38%), Gaps = 99/582 (17%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G + + Q L
Sbjct: 675 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQAL 733
Query: 137 SDGWSSQPTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ P+C + C P L+ + F +V Y C GY G
Sbjct: 734 NKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---AAS 787
Query: 195 VECLTYG-WS-LTPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
+ C G WS P C C +L+ PV + G V F C E + L GS
Sbjct: 788 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGS 845
Query: 251 DLIQCYNFG----WYPESPVCEGRRNRCPPPP-LPINSKIQTHSTTYRHGEIVHIECE-- 303
C G W PVCE + CP PP +P + G+ V+ C+
Sbjct: 846 SASYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPH 903
Query: 304 ----LNFEIHGSAEIRCE-----DGKWTEP-PKC-IEGQEKVACEEPP--FIENGAANLH 350
+F++ G + IRC +G W+ P P+C I G C+ P +
Sbjct: 904 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH----CQAPDHFLFAKLKTQTN 959
Query: 351 SKIYYNGDKVTYACKSGYLLHGSN-EITCNRGKWTLPPECVENNENCKHPPVVMNGAVAD 409
+ + G + Y C+ Y +G ITC P+ V ++CK PP +NG V
Sbjct: 960 ASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-- 1015
Query: 410 GILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKWSS-PPVC------LEPCTVNV 458
++ GS + Y C + L G + C WS+ PP+C L P N
Sbjct: 1016 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANG 1075
Query: 459 DYM--NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLC 515
D++ NR N +G ++ + C G + L E S+ C + + +
Sbjct: 1076 DFISTNRENFH----------YGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 516 TRKESK----GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC--LD 569
+ + CT PP +++G+++S + VE+RC ++G R C L+
Sbjct: 1126 SGPAPQCIIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALN 1184
Query: 570 GMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEY 611
P C C P ILHGE+
Sbjct: 1185 KWEPELPSCSRVC------------------QPPPEILHGEH 1208
Score = 124 bits (311), Expect = 3e-28
Identities = 135/536 (25%), Positives = 212/536 (39%), Gaps = 79/536 (14%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G + + Q L
Sbjct: 225 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK-CQAL 283
Query: 137 SDGWSSQPTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEE 194
+ P+C + C P L+ + F +V Y C GY G
Sbjct: 284 NKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---AAS 337
Query: 195 VECLTYG-WS-LTPKCTKLKCSSL--RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGS 250
+ C G WS P C C +L+ PV + G V F C E + L GS
Sbjct: 338 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGS 395
Query: 251 DLIQCYNFG----WYPESPVCEGRRNRCPPPP-LPINSKIQTHSTTYRHGEIVHIECE-- 303
C G W PVCE + CP PP +P + G+ V+ C+
Sbjct: 396 SASYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPH 453
Query: 304 ----LNFEIHGSAEIRCE-----DGKWTEP-PKC-IEGQEKVACEEPP--FIENGAANLH 350
+F++ G + IRC +G W+ P P+C I G C+ P +
Sbjct: 454 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH----CQAPDHFLFAKLKTQTN 509
Query: 351 SKIYYNGDKVTYACKSGYLLHGSN-EITCNRGKWTLPPECVENNENCKHPPVVMNGAVAD 409
+ + G + Y C+ Y +G ITC P+ V ++CK PP +NG V
Sbjct: 510 ASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-- 565
Query: 410 GILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKWSS-PPVC------LEPCTVNV 458
++ GS + Y C + L G + C WS+ PP+C L P N
Sbjct: 566 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANG 625
Query: 459 DYM--NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLC 515
D++ NR N +G ++ + C G + L E S+ C + + +
Sbjct: 626 DFISTNRENFH----------YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 516 TRKESK----GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
+ + CT PP +++G+++S + VE+RC ++G R C
Sbjct: 676 SGPAPQCIIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 730
Score = 119 bits (298), Expect = 9e-27
Identities = 154/606 (25%), Positives = 236/606 (38%), Gaps = 83/606 (13%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
C P+VENG + + S+++ + F C G+ + R+ + W PE
Sbjct: 688 CTPPNVENGILVSDNRSL------FSLNEVVEFRCQPGFVMKGPRRVKCQALNK--WEPE 739
Query: 85 -PRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-W 140
P C + C P L K + + + Y C GY G ++C G W
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS---MRCTPQGDW 796
Query: 141 S-SQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLT 199
S + PTC + +L NG ++ KV + C G+ G + C+
Sbjct: 797 SPAAPTCEVKSCDDFMGQLLNGRV-LFPVNLQLGAKVDFVCDEGFQLKGSSASY---CVL 852
Query: 200 YG----W-SLTPKCTKLKCSSLRLIENGYFHPVK--QTYEEGDVVQFFCHEN------YY 246
G W S P C ++ C S +I NG H K + + G V + C + +
Sbjct: 853 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 911
Query: 247 LSGSDLIQCY-----NFGWYPESPVCEGRRNRCPPPP--LPINSKIQTHSTTYRHGEIVH 299
L G I+C N W +P C G C P L K QT+++ + G +
Sbjct: 912 LIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 300 IECELNFEIHGSA-EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGD 358
EC E +G I C D PK + ++ +C+ PP NG ++ + I G
Sbjct: 971 YECRP--EYYGRPFSITCLDNLVWSSPKDV--CKRKSCKTPPDPVNGMVHVITDIQV-GS 1025
Query: 359 KVTYACKSGYLLHGSNEITC----NRGKW-TLPPECVENNENCKHPPVVMNGAVADGILA 413
++ Y+C +G+ L G + C N W T PP C C PP + NG
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC--QRIPCGLPPTIANGDFISTNRE 1083
Query: 414 SYATGSSVEYRCN------EYYLLRGSKISRC-----EQGKWSSP-PVCLEP--CTVNVD 459
++ GS V YRCN + + L G C + G WS P P C+ P CT
Sbjct: 1084 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP-- 1141
Query: 460 YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKE 519
N N + ++++F C+ G+ + P N+ E + P C+R
Sbjct: 1142 --NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKG--PRRVKCQALNKWEPELPSCSR-- 1195
Query: 520 SKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT--TPP 576
+C PP I HG S D + G V Y C + L G+ +C G W+ P
Sbjct: 1196 ---VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPR 1252
Query: 577 LCLEPC 582
++ C
Sbjct: 1253 CAVKSC 1258
Score = 115 bits (288), Expect = 1e-25
Identities = 118/457 (25%), Positives = 187/457 (40%), Gaps = 70/457 (15%)
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENG 222
T + F + + YEC GY + + CL W+ +C + C + NG
Sbjct: 58 TDEFEFPIGTYLNYECRPGY----SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNG 113
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPP 278
H +K + G +++ C + Y L GS C G W E+P+C+ R C PP
Sbjct: 114 MVHVIKGI-QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD--RIPCGLPP 170
Query: 279 LPINSK-IQTHSTTYRHGEIVHIECELN------FEIHGSAEIRCED-----GKWTEP-P 325
N I T+ + +G +V C FE+ G I C G W+ P P
Sbjct: 171 TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 230
Query: 326 KCIEGQEKVACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHGSNEITCNR-GKW 383
+CI + PP +ENG ++ ++ + V + C+ G+++ G + C KW
Sbjct: 231 QCIIPNKCT----PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 286
Query: 384 TLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQG 442
PE + C+ PP V++ +++ G V Y C Y LRG+ RC QG
Sbjct: 287 E--PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344
Query: 443 KWS-SPPVC-LEPCTVNVDYMNRNNIEMKWKYEGKVLH------GDLIDFVCKQGYDL-S 493
WS + P C ++ C D+M + G+VL G +DFVC +G+ L
Sbjct: 345 DWSPAAPTCEVKSCD---DFMGQ-------LLNGRVLFPVNLQLGAKVDFVCDEGFQLKG 394
Query: 494 PLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRC 553
L+ + P+C + C SPP+I +G ++ + G +V Y C
Sbjct: 395 SSASYCVLAGMESLWNSSVPVC----EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 450
Query: 554 FDH------HFLEGSREAYCL-----DGMWTTP-PLC 578
H L G C +G+W++P P C
Sbjct: 451 DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487
Score = 110 bits (274), Expect = 5e-24
Identities = 146/594 (24%), Positives = 234/594 (39%), Gaps = 81/594 (13%)
Query: 82 SPEPRCFKK-----CTKPD---LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVV 133
SP PRC C P+ ++ I + + ++ Y C GY GK +
Sbjct: 1382 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYF---GKMFSI- 1437
Query: 134 QCLSD-GWSS-QPTCRKEHETC-LAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGK 190
CL + WSS + CR++ +C PE +NG T + V Y C G+ G
Sbjct: 1438 SCLENLVWSSVEDNCRRK--SCGPPPEPFNGMVHINTDT-QFGSTVNYSCNEGFRLIGSP 1494
Query: 191 KTEEVECLTYGWSLT-----PKCTKLKCSSLRLIENGYFHPVKQT-YEEGDVVQFFCHEN 244
T CL G ++T P C + C I NG F+ +T + G VV + CH
Sbjct: 1495 STT---CLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG 1551
Query: 245 ------YYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYR 293
+ L G I C + W P C N+C P + ++ + + +
Sbjct: 1552 PDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIST-NKCTAPEVENAIRVPGNRSFFT 1610
Query: 294 HGEIVHIECELNFEIHGSAEIRCE-DGKW-TEPPKCIEGQEKVACEEPPFIENGAANL-H 350
EI+ C+ F + GS ++C+ +G+W + P C C+ PP I +G L H
Sbjct: 1611 LTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR-----VCQPPPEILHGEHTLSH 1665
Query: 351 SKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHPPVVMNGAVA 408
+ G +V Y+C+ Y L G+ + C +G W+ P C ++C G +
Sbjct: 1666 QDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTV--KSCDD----FLGQLP 1719
Query: 409 DG---ILASYATGSSVEYRCNEYYLLRGSKISRCE----QGKW-SSPPVCLEP-CTVNVD 459
G + + G+ V + C+E + L+G S C + W SS PVC + C
Sbjct: 1720 HGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPA 1779
Query: 460 YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLS-PLTPLSELSVQCNRG-------EVK 511
+N + + G + +G I + C D + E S++C
Sbjct: 1780 ILNGRHTGTPF---GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSP 1836
Query: 512 YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-G 570
P C C PP I++G I V Y G ++ Y C + L G +C D G
Sbjct: 1837 APRC-ELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 1895
Query: 571 MWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAE 624
+W+ + SF + N + + + H +G+Y+ C D Y E
Sbjct: 1896 IWSQLDHYCKEVNCSF-PLFMNGISKELEMKKVYH--YGDYVTLKCE-DGYTLE 1945
Score = 102 bits (254), Expect = 1e-21
Identities = 123/472 (26%), Positives = 188/472 (39%), Gaps = 76/472 (16%)
Query: 74 TTCTTEG----WSPE-PRC-FKKCTKPD-LSNG-YISDVKLLYKIQENMRYGCASG---- 121
TTC G W + P C C P +SNG + S+ + + + Y C +G
Sbjct: 1496 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 1555
Query: 122 --YKTTGGKDEEVVQCLSDG-----WSSQPTCRKEHETCLAPELYNG-NYSTTQKTFKVK 173
++ G E + C S WSS P C APE+ N + F +
Sbjct: 1556 QLFELVG---ERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLT 1612
Query: 174 DKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQTY 231
+ +++ C G+ G + V+C T G W P C+++ ++ + + +
Sbjct: 1613 EIIRFRCQPGFVMVG---SHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNF 1669
Query: 232 EEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRR-----NRCPPPP--LPINS 283
G V + C +Y L G+ + C G W PE+P C + + P LP+N
Sbjct: 1670 SPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL 1729
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWTEP-PKCIEGQEKVACEE 338
++ G V C+ F + G + C W P C E++ C
Sbjct: 1730 QL---------GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC----EQIFCPN 1776
Query: 339 PPFIENG--AANLHSKIYYNGDKVTYACKSG------YLLHGSNEITCN-----RGKWTL 385
PP I NG I Y G +++YAC + + L G + I C G W+
Sbjct: 1777 PPAILNGRHTGTPFGDIPY-GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS 1835
Query: 386 P-PEC-VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQG 442
P P C + C HPP + NG G ++ Y G ++ Y C+ YLL G C +QG
Sbjct: 1836 PAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG 1895
Query: 443 KWSS-PPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLH-GDLIDFVCKQGYDL 492
WS C E +MN + E++ K KV H GD + C+ GY L
Sbjct: 1896 IWSQLDHYCKEVNCSFPLFMNGISKELEMK---KVYHYGDYVTLKCEDGYTL 1944
Score = 100 bits (250), Expect = 3e-21
Identities = 136/596 (22%), Positives = 222/596 (37%), Gaps = 102/596 (17%)
Query: 47 FPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSP-EPRCFKKCT--KPDLSNGYISD 103
F + L++ C GY G+ + WS E C +K P+ NG +
Sbjct: 1414 FEFPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVH- 1469
Query: 104 VKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG----WSSQ-PTCRKEHETCLAPE- 157
+ + + Y C G++ G CL G W + P C E +C P
Sbjct: 1470 INTDTQFGSTVNYSCNEGFRLIGSPS---TTCLVSGNNVTWDKKAPIC--EIISCEPPPT 1524
Query: 158 LYNGN-YSTTQKTFKVKDKVQYECATG------YYTAGGKK---TEEVECLTYGWSLTPK 207
+ NG+ YS + +F V Y+C TG + G + T + + + S P+
Sbjct: 1525 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 1584
Query: 208 CTKLKCSSLRLIENGYFHPVKQTYEE-GDVVQFFCHENYYLSGSDLIQCYNFG-WYPESP 265
C + +EN P +++ ++++F C + + GS +QC G W P+ P
Sbjct: 1585 CISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLP 1644
Query: 266 VCEGRRNRCPPPPLPINSK-IQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT- 322
C C PPP ++ + +H + G+ V CE ++++ G+A + C G W+
Sbjct: 1645 HCS---RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 1701
Query: 323 EPPKC-IEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC--- 378
E P+C ++ + + P +G L + G KV++ C G+ L G + C
Sbjct: 1702 EAPRCTVKSCDDFLGQLP----HGRVLLPLNLQL-GAKVSFVCDEGFRLKGRSASHCVLA 1756
Query: 379 -NRGKWTLP-PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEY------YL 430
+ W P C + C +PP ++NG G + Y C+ + +
Sbjct: 1757 GMKALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFN 1814
Query: 431 LRGSKISRCEQ-----GKWSSPP---------VCLEPCTVNVDYMNRNNIEMKWKYEGKV 476
L G RC G WSSP C P + + ++ +
Sbjct: 1815 LIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL-------Y 1867
Query: 477 LHGDLIDFVCKQGYDL--------SPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPP 528
L G I ++C GY L + S+L C +PL SK +
Sbjct: 1868 LPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKEL----- 1922
Query: 529 LIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC-LDGMWTTPPLCLEPCT 583
Y G V +C D + LEGS + C D W P L CT
Sbjct: 1923 ---------EMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPP---LAKCT 1966
Score = 96.7 bits (239), Expect = 6e-20
Identities = 126/542 (23%), Positives = 210/542 (38%), Gaps = 76/542 (14%)
Query: 82 SPEPRC--FKKCTKPDLSNGYISDVKLL-------YKIQENMRYGCASGYKTTGGKDEEV 132
SP PRC C PD + KL + I +++Y C Y G+ +
Sbjct: 482 SPAPRCGILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSI 534
Query: 133 VQCLSD-GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKK 191
CL + WSS K P+ NG +V ++ Y C TG+ G
Sbjct: 535 T-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSS 592
Query: 192 TEEVECLTYG----WSLTPK-CTKLKCSSLRLIENGYFHPV-KQTYEEGDVVQFFCHEN- 244
E C+ G WS P C ++ C I NG F ++ + G VV + C+
Sbjct: 593 AE---CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGS 649
Query: 245 -----YYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH 294
+ L G I C + W +P C N+C PP + + + + +
Sbjct: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTPPNVENGILVSDNRSLFSL 708
Query: 295 GEIVHIECELNFEIHGSAEIRCED-GKW-TEPPKCIEGQEKVACEEPPFIENGAANLHSK 352
E+V C+ F + G ++C+ KW E P C C+ PP + + K
Sbjct: 709 NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR-----VCQPPPDVLHAERTQRDK 763
Query: 353 IYYN-GDKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNENCKHPPVVMNGAVADG 410
++ G +V Y+C+ GY L G+ + C +G W+ E ++NG V
Sbjct: 764 DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823
Query: 411 ILASYATGSSVEYRCNEYYLLRGSKISRC----EQGKW-SSPPVCLEPCTVNVDYMNRNN 465
+ + G+ V++ C+E + L+GS S C + W SS PVC + +
Sbjct: 824 V--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ------IFCPSPP 875
Query: 466 IEMKWKYEGKVLH----GDLIDFVCKQGYDL-SPLTPLSELSVQC-----NRGEVKYPLC 515
+ ++ GK L G +++ C D + + E +++C G P
Sbjct: 876 VIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSP-A 934
Query: 516 TRKESKGMCTSPPLIKHGVIISST-VDTYENGSSVEYRCFDHHFLEGSREAYCLDGM-WT 573
R G C +P + + T + G+S++Y C ++ CLD + W+
Sbjct: 935 PRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY-GRPFSITCLDNLVWS 993
Query: 574 TP 575
+P
Sbjct: 994 SP 995
Score = 92.8 bits (229), Expect = 9e-19
Identities = 125/528 (23%), Positives = 200/528 (37%), Gaps = 79/528 (14%)
Query: 82 SPEPRC--FKKCTKPDLSNGYISDVKLL-------YKIQENMRYGCASGYKTTGGKDEEV 132
SP PRC C PD + KL + I +++Y C Y G+ +
Sbjct: 932 SPAPRCGILGHCQAPD----HFLFAKLKTQTNASDFPIGTSLKYECRPEYY---GRPFSI 984
Query: 133 VQCLSD-GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKK 191
CL + WSS K P+ NG +V ++ Y C TG+ G
Sbjct: 985 T-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSS 1042
Query: 192 TEEVECLTYG----WSLTPK-CTKLKCSSLRLIENGYFHPV-KQTYEEGDVVQFFCH--- 242
E C+ G WS P C ++ C I NG F ++ + G VV + C+
Sbjct: 1043 AE---CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGS 1099
Query: 243 ---ENYYLSGSDLIQCYNFG-----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH 294
+ + L G I C + W +P C N+C PP + + + + +
Sbjct: 1100 RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTPPNVENGILVSDNRSLFSL 1158
Query: 295 GEIVHIECELNFEIHGSAEIRCED-GKWT-EPPKCIEGQEKVACEEPPFIENGAAN-LHS 351
E+V C+ F + G ++C+ KW E P C C+ PP I +G H
Sbjct: 1159 NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR-----VCQPPPEILHGEHTPSHQ 1213
Query: 352 KIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHPPVVMNGAVAD 409
+ G +V Y+C+ GY L G+ + C +G W+ P C ++C G +
Sbjct: 1214 DNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAV--KSCDD----FLGQLPH 1267
Query: 410 GILA---SYATGSSVEYRCNEYYLLRGSKISRC----EQGKW-SSPPVCLEPCTVNVDYM 461
G + + G+ V + C+E + L+GS +S C + W +S PVC N +
Sbjct: 1268 GRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAI 1327
Query: 462 NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLS-PLTPLSELSVQCNRG-------EVKYP 513
N G + +G I + C D + E +++C P
Sbjct: 1328 --LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1385
Query: 514 LCTRKESKGMCTSP---PLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
C G C +P P + I+ + G+S+ Y C +F
Sbjct: 1386 RCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLNYECRPGYF 1431
Score = 65.5 bits (158), Expect = 2e-10
Identities = 95/391 (24%), Positives = 146/391 (37%), Gaps = 49/391 (12%)
Query: 25 CGFPHVENG-RIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS 82
C P VEN R+ +SF+ ++ + + F C G+ + C T G W
Sbjct: 1591 CTAPEVENAIRVPGN----RSFF---TLTEIIRFRCQPGFVMVGSHTVQ---CQTNGRWG 1640
Query: 83 PE-PRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
P+ P C + C P L + + + + + Y C Y G + C G
Sbjct: 1641 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAAS---LHCTPQG 1697
Query: 140 -WSSQ-PTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVEC 197
WS + P C + +L +G ++ KV + C G+ G + C
Sbjct: 1698 DWSPEAPRCTVKSCDDFLGQLPHGRV-LLPLNLQLGAKVSFVCDEGFRLKGRSASH---C 1753
Query: 198 LTYG----W-SLTPKCTKLKCSSLRLIENGYFHPVK-QTYEEGDVVQFFCHEN------Y 245
+ G W S P C ++ C + I NG G + + C + +
Sbjct: 1754 VLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTF 1813
Query: 246 YLSGSDLIQCY-----NFGWYPESPVCE-GRRNRCPPPPLPINSK-IQTHSTTYRHGEIV 298
L G I+C N W +P CE CP PP N I H + Y G +
Sbjct: 1814 NLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTI 1873
Query: 299 HIECELNFEIHGSAEIRCED-GKWTEPPKCIEGQEKVACEEPPFIENGAANLH-SKIYYN 356
C+ + + G I C D G W++ + +V C P F+ + L K+Y+
Sbjct: 1874 SYICDPGYLLVGKGFIFCTDQGIWSQLDHYCK---EVNCSFPLFMNGISKELEMKKVYHY 1930
Query: 357 GDKVTYACKSGYLLHGSNEITCNR-GKWTLP 386
GD VT C+ GY L GS C +W P
Sbjct: 1931 GDYVTLKCEDGYTLEGSPWSQCQADDRWDPP 1961
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 118 bits (295), Expect = 2e-26
Identities = 118/455 (25%), Positives = 179/455 (39%), Gaps = 75/455 (16%)
Query: 162 NYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLI 219
N S F + + C GY G K +ECL G W+ P+C +C L++
Sbjct: 212 NCSHPLGNFSFNSQCSFHCTDGYQVNGPSK---LECLASGIWTNKPPQCLAAQCPPLKIP 268
Query: 220 ENGYF---HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCP 275
E G H K ++ F C E + L G +++QC G W +PVC+ + +
Sbjct: 269 ERGNMTCLHSAK-AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
Query: 276 PPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED-GKWTEP-PKCIEGQEK 333
P T + +G EC+ + + G +RC D G W+ P P C E
Sbjct: 328 EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC----EA 383
Query: 334 VACE--EPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PEC 389
++CE E P + + + + ++ C G++L G++ + C N G+WT P P C
Sbjct: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
Query: 390 V-----------ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISR 438
E NC HP ++ S + CNE LL G+ + +
Sbjct: 444 QALQCQDLPVPNEARVNCSHP------------FGAFRYQSVCSFTCNEGLLLVGASVLQ 491
Query: 439 C-EQGKWSS-PPVCLE-PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
C G W+S PP C PCT + +N + G + F+C +GY LS
Sbjct: 492 CLATGNWNSVPPECQAIPCTPLLS--PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGP 549
Query: 496 TPLSELSVQCNRGEVKYPLCTRK----ESKGMCTS---PPLI---KHGVIISSTVDTYEN 545
L CTR +S MC + P L + + S T +
Sbjct: 550 ERLD---------------CTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNV 594
Query: 546 GSSVEYRCFDHHFLEGSREAYC-LDGMWT-TPPLC 578
GS+ + C + LEG C G W+ TPP C
Sbjct: 595 GSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
Score = 103 bits (256), Expect = 7e-22
Identities = 108/424 (25%), Positives = 169/424 (39%), Gaps = 44/424 (10%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRCFKKCTKPDLSNGY----ISDVKLLYKI 110
F C GY R + C G WS P P C +P S + S ++
Sbjct: 352 FECQPGYRV---RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQY 408
Query: 111 QENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRK-EHETCLAPELYNGNYSTTQ 167
N + CA G+ G ++V+C + G W++ P C+ + + P N S
Sbjct: 409 DTNCSFRCAEGFMLRGA---DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
Query: 168 KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-W-SLTPKCTKLKCSSLRLIENGYFH 225
F+ + + C G G ++CL G W S+ P+C + C+ L +NG
Sbjct: 466 GAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIPCTPLLSPQNGTMT 522
Query: 226 PVKQTYEEG--DVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPIN 282
V+ QF C E Y LSG + + C G W P+CE +CP P
Sbjct: 523 CVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA--IKCPELFAPEQ 580
Query: 283 SKIQTHST--TYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKC--IEGQEKVAC 336
+ T + G H C+ F++ G + C G+W+ PP C I
Sbjct: 581 GSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGV 640
Query: 337 EEPPFIENGAANL----HSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWT-LPPEC- 389
+ P G + H + + C +G+ L G + ++C G+WT + P C
Sbjct: 641 QCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR 700
Query: 390 -VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP 447
V+ +E + P+ MN + +++ GS + C E LL GS + C E G WS+
Sbjct: 701 AVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTT 757
Query: 448 -PVC 450
P C
Sbjct: 758 VPTC 761
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 118 bits (295), Expect = 2e-26
Identities = 159/599 (26%), Positives = 231/599 (38%), Gaps = 83/599 (13%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
F C G+ E C + G WS E RC C P+L NG + Y ++
Sbjct: 2743 FTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN--YGYRD 2797
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSD-GWSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
+ Y C G++ G V C D WS Q P+C +Y T+ F
Sbjct: 2798 TVVYQCNPGFRLIGSS---VRICQQDHNWSGQLPSCVPVSCGHPGSPIYG---RTSGNGF 2851
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVEC-LTYGWSLTPK-CTKLKCSSLRL---------I 219
D V + C GY G K + C WS P C + CS + I
Sbjct: 2852 NFNDVVTFSCNIGYLMQGPTKAQ---CQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2908
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPL 279
E+G F TY G VV + C+ Y+L GS ++ C G + + P+ E C P +
Sbjct: 2909 EHGNF-----TY--GTVVFYDCNPGYFLFGSSVLICQPNGQW-DKPLPECIMIDCGHPGV 2960
Query: 280 PINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWTEPPKCIEGQEKVACEE 338
P N+ + T+ G VH C + G + C+ +G W+ G C +
Sbjct: 2961 PPNAVLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 3018
Query: 339 PPFIENGA---ANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENN 393
P +G+ +N +K V YAC +GY+LHGS E TC G WT PEC
Sbjct: 3019 PGTPGHGSRQESNFRTK-----STVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA 3071
Query: 394 ENCKHPPVVMNGAV--ADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSPPVC 450
C +P NG V DG S SSV Y C E Y+L G + +C G WS
Sbjct: 3072 VQCGNPGTTANGKVFRIDGTTFS----SSVIYSCMEGYILSGPSVRQCTANGTWSG---T 3124
Query: 451 LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEV 510
L CT+ + + +Y + G + ++C+ GY +
Sbjct: 3125 LPNCTI-ISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSG 3183
Query: 511 KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-D 569
P C C +PP I +G + + D G S+ Y C + L C+ +
Sbjct: 3184 VMPTCRAV----TCPTPPQISNGRLEGTNFDW---GFSISYICSPGYELSFPAVLTCVGN 3236
Query: 570 GMWT------TPPLCLEPCTLSFTEMEKNNLLLKWDFD---NRPHILHGEYIEFICRGD 619
G W+ P C +P + + E + + + + N P IL G IC+ D
Sbjct: 3237 GTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR-ICQAD 3294
Score = 115 bits (288), Expect = 1e-25
Identities = 129/490 (26%), Positives = 198/490 (40%), Gaps = 58/490 (11%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPE---LYNGN 162
Y + + Y C GY+ + K+ C SDG WS+ T R TC + L +G
Sbjct: 2608 YLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2666
Query: 163 YSTTQKT-FKVKDKVQYECATGYYTAGGKKTEEVECL---TYGW-SLTPKCTKLKCSSLR 217
+ + ++ K KV + C GY+ G +ECL T+ W + P C + C L
Sbjct: 2667 WRIVNGSHYEYKTKVVFSCDPGYHGLG---PASIECLPNGTWSWRNERPYCQIISCGELP 2723
Query: 218 LIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
NG + +Y G F C + L GS + +C + G + ES C P
Sbjct: 2724 TPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESET-RCLAGHCGIP 2780
Query: 278 PLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVA 335
L +N ++ + YR + V +C F + GS+ C +D W+ + P C+ V+
Sbjct: 2781 ELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCV----PVS 2834
Query: 336 CEEPPFIENGAANLHSKIYYNG----DKVTYACKSGYLLHGSNEITCNRGK-WTLPPECV 390
C P + ++ + NG D VT++C GYL+ G + C + W+ PP
Sbjct: 2835 CGHP------GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2888
Query: 391 ENNENCKHPPVVMNGAVADGI-LASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSP- 447
+ NC P + N I ++ G+ V Y CN Y L GS + C+ G+W P
Sbjct: 2889 K-VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPL 2947
Query: 448 PVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-- 505
P C + +D + K G + + C L L + S C
Sbjct: 2948 PEC-----IMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL-----LGQSSRTCQL 2997
Query: 506 -NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSRE 564
P C+ ++ G C P HG S + S+V Y C + L GS E
Sbjct: 2998 NGHWSGSQPHCS-GDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEE 3053
Query: 565 AYCL-DGMWT 573
CL +G WT
Sbjct: 3054 RTCLANGSWT 3063
Score = 94.7 bits (234), Expect = 2e-19
Identities = 108/409 (26%), Positives = 165/409 (40%), Gaps = 37/409 (9%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
+ C GY E+ TC G W+ +P C +C P + NG + +
Sbjct: 3040 YACDTGYILHGS---EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGT-TFSS 3095
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
++ Y C GY +G V QC ++G WS P C +C P + N +
Sbjct: 3096 SVIYSCMEGYILSG---PSVRQCTANGTWSGTLPNCTII--SCGDPGI-PANGLRYGDDY 3149
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQ 229
V V Y C GY + WS + P C + C + I NG
Sbjct: 3150 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN- 3208
Query: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINSKIQTH 288
++ G + + C Y LS ++ C G W E P C + C P +P K +
Sbjct: 3209 -FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKF--CGDPGIPAQGKREGK 3265
Query: 289 STTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKVACEEPPFIENGA 346
S Y+ V C F + GS+ C+ DG W+ P CIE + +CE P +G+
Sbjct: 3266 SFIYQSE--VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ-TSCENPGVPRHGS 3322
Query: 347 ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWT-LPPECVENNENCKHPPVVMN 404
N ++ + G V + CK G+LL GS TC W+ + PEC+ + +CK P +
Sbjct: 3323 QN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPH--SCKQPETPAH 3379
Query: 405 GAVADGILASYATGSSVEYRCNEYYLLRGS---KISRCEQGKWSSPPVC 450
V L S+ G ++ Y C + L G ++ R + P+C
Sbjct: 3380 ANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426
Score = 87.8 bits (216), Expect = 3e-17
Identities = 128/556 (23%), Positives = 190/556 (34%), Gaps = 110/556 (19%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQ 167
+ + + + C GY G QC ++ S P + C P + + ++
Sbjct: 2851 FNFNDVVTFSCNIGYLMQGPTK---AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2907
Query: 168 ---KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKCSSLRLIENG 222
F V Y+C GY+ G + + C G W P+C + C + N
Sbjct: 2908 IEHGNFTYGTVVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA 2964
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEG-RRNRCPPPPLP 280
K T+ G V + C L G C N W P C G C P P
Sbjct: 2965 VLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP 3022
Query: 281 INSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEE 338
+ Q + +R V C+ + +HGS E C +G WT P+C + V C
Sbjct: 3023 GHGSRQ--ESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC----KAVQCGN 3076
Query: 339 PPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWT-LPPECVENNENC 396
P NG ++ V Y+C GY+L G + C G W+ P C + C
Sbjct: 3077 PGTTANGKVFRIDGTTFSSS-VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS--C 3133
Query: 397 KHPPVVMNGAVADGILASYATGSSVEYRCNEYYL--LRGSKISRCE-QGKWSSP-PVCLE 452
P + NG Y G +V Y C Y L GS+I C G WS P C
Sbjct: 3134 GDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRA 3190
Query: 453 PCTVNVDYMNRNNIE---MKWKYEGKVLHGDLIDFVCKQGYDLS---------------- 493
++ +E W + I ++C GY+LS
Sbjct: 3191 VTCPTPPQISNGRLEGTNFDWGFS--------ISYICSPGYELSFPAVLTCVGNGTWSGE 3242
Query: 494 -----------PLTPL------------SELSVQCNRGEVKYPLCTR------------- 517
P P SE+S CN + TR
Sbjct: 3243 VPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3302
Query: 518 ---KESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
+ ++ C +P + +HG + ++ GS V++ C H L+GS CL D W+
Sbjct: 3303 HCIEPTQTSCENPGVPRHGS--QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3360
Query: 574 ------TPPLCLEPCT 583
P C +P T
Sbjct: 3361 GIQPECIPHSCKQPET 3376
Score = 61.2 bits (147), Expect = 3e-09
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 30/303 (9%)
Query: 51 IDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS---PEPRCFKKCTKPDLSNGYISDVKL 106
+ + +S+ C GYT E + TCT G WS P R T P +SNG +
Sbjct: 3151 VGQNVSYMCQPGYTMELNGSRIR-TCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF 3209
Query: 107 LYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYS 164
+ ++ Y C+ GY+ + V+ C+ +G WS + P C + C P +
Sbjct: 3210 DWGF--SISYICSPGYELS---FPAVLTCVGNGTWSGEVPQCLPKF--CGDPGI-PAQGK 3261
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKC---TKLKCSSLRLI 219
K+F + +V + C + G C G WS +P C T+ C + +
Sbjct: 3262 REGKSFIYQSEVSFSCNFPFILVGSSTR---ICQADGTWSGSSPHCIEPTQTSCENPGVP 3318
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPP 278
+G + ++ G VVQF C + + L GS C + W P C + C P
Sbjct: 3319 RHGSQNNT-FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC--IPHSCKQPE 3375
Query: 279 LPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC--EDGKWTEPPKCIEGQEKVAC 336
P ++ + HG + C+ F + G E R D WT E K+
Sbjct: 3376 TPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILV 3434
Query: 337 EEP 339
++P
Sbjct: 3435 KDP 3437
Score = 45.8 bits (107), Expect = 1e-04
Identities = 137/618 (22%), Positives = 206/618 (33%), Gaps = 133/618 (21%)
Query: 47 FPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG---WS-PEPRCFKKCTKPDLSNGYIS 102
F I L+F C +GY E + C G WS P PRC +C +N I
Sbjct: 1156 FNFGIGDTLTFSCSSGYRLEG---TSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1212
Query: 103 DVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGN 162
+ Y + + C + GK + S T L ++Y+G
Sbjct: 1213 -LSPNYPLNYENNHECIYSIQVQAGKGINI---------SARTFHLAQGDVL--KIYDGK 1260
Query: 163 YSTTQK--TFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLK-CSSLRLI 219
TT F ++ + + E G+ L +L C +
Sbjct: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1320
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF---GW-YPESPV---CEGR-- 270
+ GY Q + G + + C+ Y L GS L++C W YP C GR
Sbjct: 1321 QFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFK 1379
Query: 271 -----RNRCPPPPLPINSKIQTH-STTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 324
R P P P ++ ++ G IV ++ L F+ S +I W P
Sbjct: 1380 GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQF-LAFDTEASHDIL---RVWDGP 1435
Query: 325 PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWT 384
P E + I G + + + D Y KSG+ + S+ +
Sbjct: 1436 P---ENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA----- 1487
Query: 385 LPPECVENNENCKHPPVVMNGAV-ADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK 443
C+ P V MNG DG G +V ++C+ Y L+G + C Q +
Sbjct: 1488 -----------CRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE 1532
Query: 444 ----WS-SPPVCLEPC------------------------------TVNVDYM------- 461
W SPPVC+ PC TVN DY+
Sbjct: 1533 NRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFIS 1592
Query: 462 --NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC------NRGEVKYP 513
N + + Y+G + LI + S L E S + G V Y
Sbjct: 1593 FSIEPNYDFLYIYDGPDSNSPLIG-----SFQDSKLPERIESSSNTMHLAFRSDGSVSYT 1647
Query: 514 ---LCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG 570
L + + + C P I +G + Y+ GS+V Y C + L+G C+ G
Sbjct: 1648 GFHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAGYVLQGYSTLTCIMG 1704
Query: 571 MWTTP------PLCLEPC 582
P P C PC
Sbjct: 1705 DDGRPGWNRALPSCHAPC 1722
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/225 (23%), Positives = 78/225 (34%), Gaps = 64/225 (28%)
Query: 415 YATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWS-SPPVCLEPC----------TVNV 458
+A GSSV + CN Y+L GS RCE +W+ S P C+ PC ++
Sbjct: 1854 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1913
Query: 459 DYMN--RNNIEMKWKY---EGKVLHGDLIDFVCKQGYDLSP------------------- 494
Y NN+ WK EG + ++ F + +D
Sbjct: 1914 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1973
Query: 495 -------------LTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVD 541
L S++SV ++Y C P G+ I D
Sbjct: 1974 IPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI----GLDSCPEPQTPSSGIKIG---D 2026
Query: 542 TYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPC 582
Y G V ++C + L+G C+ G W P P+CL C
Sbjct: 2027 RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2071
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/215 (25%), Positives = 75/215 (34%), Gaps = 63/215 (29%)
Query: 234 GDVVQFFCHENYYLSGSDLIQC-YNFGWYPESPVCE---GRRNRCPP--------PPLPI 281
G V F C Y LS + + C N W P C+ G R P P
Sbjct: 989 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYP 1048
Query: 282 NSKIQTHSTTYRHGEIVHIECE-LNFEIHGSAEIRCEDGKWTEPPKCIEGQE-------- 332
NS T + HG+ V + E H + E+G +T+P + G +
Sbjct: 1049 NSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAG 1108
Query: 333 ------------------------------KVACEEPPFIENGAANLHSKIYYN---GDK 359
CE+P G S+I +N GD
Sbjct: 1109 LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP-----GIPQYGSRIGFNFGIGDT 1163
Query: 360 VTYACKSGYLLHGSNEITC---NRGKWTLP-PECV 390
+T++C SGY L G++EI C R W+ P P CV
Sbjct: 1164 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Score = 41.6 bits (96), Expect = 0.002
Identities = 91/427 (21%), Positives = 145/427 (33%), Gaps = 117/427 (27%)
Query: 272 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNF-EIHGSAEIRC--EDGK--WTEP-P 325
N CP P +PIN++ ++ G + + CE F + G+ I C DGK W+ P
Sbjct: 792 NECPDPGIPINAR--RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 849
Query: 326 KCIEG---------------------QEKVACEEPPFIENGAA----------------- 347
KC ++ + CE E G +
Sbjct: 850 KCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVL 909
Query: 348 ------NLHSKIY--YNGDKVTYACKSG----YLLHGSNEITCNRGKWTLPPECVENNEN 395
NL S + YNG +V S YLL ++ N G N +
Sbjct: 910 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV------ 449
C P + ++G ++ GS+V + C+ Y L + CE+ W S P+
Sbjct: 970 CLDPGIPVHGRRYGH---DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1026
Query: 450 -----------CLEP-----------CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCK 487
L P CT VD + ++ + H D + + +
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL-LITE 1085
Query: 488 QGYDLSPLTPL--SELSVQCNRG---------------EVKYP---LCTRKESKGMCTSP 527
G PL L S+L N G + Y + + + C P
Sbjct: 1086 NGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP 1145
Query: 528 PLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPCT 583
+ ++G I + G ++ + C + LEG+ E CL G +W+ P P C+ C
Sbjct: 1146 GIPQYGSRIGFN---FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1202
Query: 584 LSFTEME 590
S T E
Sbjct: 1203 ASATNNE 1209
Score = 40.0 bits (92), Expect = 0.007
Identities = 54/231 (23%), Positives = 86/231 (37%), Gaps = 33/231 (14%)
Query: 360 VTYACKSGYLLHGSNEITCNRGK-----WTLP-PECVENNENCKHPPVVMNGAVADGILA 413
V +AC G+ L G + C + W P P C +C P NG + +
Sbjct: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC--QAISCGIPKAPTNGGI---LTT 2606
Query: 414 SYATGSSVEYRCNEYYLLRGSKISRC---EQGKWSSPPVCLEPCTVNVDYMNRNNIEM-K 469
Y G+ V Y CN+ Y L +++ G WS+ V +N +E +
Sbjct: 2607 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2666
Query: 470 WKYEGKVLHGDLIDFVCKQGYDLSP-LTPLSELSVQCNRGEV-----KYPLCTRKESKGM 523
W ++++G ++ K + P L S++C + P C +
Sbjct: 2667 W----RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGEL 2722
Query: 524 CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
T P K G T +Y GS+ + C L GS CL G+W+
Sbjct: 2723 PTPPNGNKIG-----TQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWS 2766
Score = 38.9 bits (89), Expect = 0.015
Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 61/247 (24%)
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSS-PPV 449
C P NG I + ++ GS+V++ C+E Y+L+G+K C++ WS PV
Sbjct: 446 CPDPGEPENGK---RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502
Query: 450 C-LEPC------------TVNVDYMNRNNIEMKWKY----EGKVLHGDLIDFVCKQGYDL 492
C ++ C + N + +N + W KV+ + +F + GYD
Sbjct: 503 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDT 562
Query: 493 ----------SPLTPLS--------------------ELSVQCNRGEVKYPLCTRKESKG 522
P T L L + G V + + ++ K
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 622
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTP-PLCLE 580
C P +G+ D + N + + C L G + C + W+ P+C+
Sbjct: 623 SCGDPGTPLYGI---REGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 679
Query: 581 PCTLSFT 587
PC +FT
Sbjct: 680 PCLSNFT 686
Score = 36.6 bits (83), Expect = 0.076
Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 7/73 (9%)
Query: 329 EGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-----NRGKW 383
E + +C P G L+ + GDK+ Y+C +GY+L G ++TC N W
Sbjct: 131 EELQSSSCGNPGVPPKGV--LYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASW 188
Query: 384 TLPPECVENNENC 396
P + C
Sbjct: 189 DFPVPICRAEDAC 201
Score = 36.2 bits (82), Expect = 0.099
Identities = 53/265 (20%), Positives = 94/265 (35%), Gaps = 32/265 (12%)
Query: 202 WSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-- 259
+ P+ + +CSS+ E + + + G V F C+ Y L GS I+C
Sbjct: 1827 YQAVPRTSSTQCSSVP--EPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1884
Query: 260 ---WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC 316
W P C P + K S Y ++ C + A I+
Sbjct: 1885 LAQWNDSLPTCI-----VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQV 1939
Query: 317 EDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKS---GYLLHGS 373
+ + + + F + G N Y+G + + S L+
Sbjct: 1940 Q---------VVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQ 1990
Query: 374 NEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRG 433
++I+ + + L + ++C P +G I Y G V ++C++ Y L+G
Sbjct: 1991 SDISVSAAGFHLEYTAI-GLDSCPEPQTPSSGIK---IGDRYMVGDVVSFQCDQGYSLQG 2046
Query: 434 SKISRCEQG---KWSSP-PVCLEPC 454
C G +W+ P P+CL C
Sbjct: 2047 HSHITCMPGPVRRWNYPIPICLAQC 2071
Score = 36.2 bits (82), Expect = 0.099
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTE----PPKC 327
C PPP N++I T + G+I+ +C F + G+A + C G+ + PP C
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC 2412
Score = 34.3 bits (77), Expect = 0.38
Identities = 29/99 (29%), Positives = 39/99 (39%), Gaps = 18/99 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLP------PE 388
+C +P I NG Y G VTY C +GY+L G + +TC G P P
Sbjct: 1660 SCFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717
Query: 389 CVENNENCKHPPVVMNGAVADGILAS--YATGSSVEYRC 425
C H P ++G + S Y SV + C
Sbjct: 1718 C--------HAPCGSRSTGSEGTVLSPNYPKNYSVGHNC 1748
Score = 32.7 bits (73), Expect = 1.1
Identities = 54/259 (20%), Positives = 95/259 (36%), Gaps = 48/259 (18%)
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF-----GWYPESPVC------- 267
ENG + + G VQF C E+Y L G+ I C W PVC
Sbjct: 453 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGS 510
Query: 268 --EGRRNRCPPPPLPI----NSKIQTHSTTYRHGEIVHIEC-ELNFEIHGSAEIRCEDGK 320
+G P P N++ T +++ I E + EI G + DG
Sbjct: 511 NLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI-GYDTLTIGDGG 569
Query: 321 WTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
P+ + + F+ + ++ S+++ LH + +
Sbjct: 570 EVGDPRTV-----LQVLTGSFVPDLIVSMSSQMW---------------LHLQTDESVGS 609
Query: 381 GKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC- 439
+ + + +E E+C P + G + +G ++ + + C + L G K C
Sbjct: 610 VGFKVNYKEIE-KESCGDPGTPLYG-IREG--DGFSNRDVLRFECQFGFELIGEKSIVCQ 665
Query: 440 EQGKWSSP-PVCLEPCTVN 457
E +WS+ P+C+ PC N
Sbjct: 666 ENNQWSANIPICIFPCLSN 684
Score = 32.7 bits (73), Expect = 1.1
Identities = 63/293 (21%), Positives = 108/293 (36%), Gaps = 55/293 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTLP-PECV 390
+C +P NG + + G +++ C GY L G++ +TC G W P P C
Sbjct: 2183 SCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC- 2239
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGKWSSPP 448
C MNG + Y+ G EY + ++L+R PP
Sbjct: 2240 --EALCGGNITAMNGTI-------YSPGYPDEYPNFQDCFWLVR-------------VPP 2277
Query: 449 VCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG 508
N Y+N ++ + Y+ + D D Q S T L + N+
Sbjct: 2278 -------GNGIYINFTVLQTEPIYD-FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQI 2329
Query: 509 EVK----------YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
+K + L +C PP + + I++ D +E G + Y+C
Sbjct: 2330 LIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFT 2388
Query: 559 LEGSREAYCLDG----MWTTPPLCLEPCTLSFTEMEKNNLLLKWDF-DNRPHI 606
L G+ C G M PP+C C + ++ ++L + D+ P++
Sbjct: 2389 LVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNL 2441
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 5/55 (9%)
Query: 329 EGQEKVA---CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
EG K A C +P ENG + G V ++C Y+L G+ ITC R
Sbjct: 436 EGGIKTASNLCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQR 488
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 118 bits (295), Expect = 2e-26
Identities = 159/599 (26%), Positives = 231/599 (38%), Gaps = 83/599 (13%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
F C G+ E C + G WS E RC C P+L NG + Y ++
Sbjct: 2614 FTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN--YGYRD 2668
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSD-GWSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
+ Y C G++ G V C D WS Q P+C +Y T+ F
Sbjct: 2669 TVVYQCNPGFRLIGSS---VRICQQDHNWSGQLPSCVPVSCGHPGSPIYG---RTSGNGF 2722
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVEC-LTYGWSLTPK-CTKLKCSSLRL---------I 219
D V + C GY G K + C WS P C + CS + I
Sbjct: 2723 NFNDVVTFSCNIGYLMQGPTKAQ---CQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2779
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPL 279
E+G F TY G VV + C+ Y+L GS ++ C G + + P+ E C P +
Sbjct: 2780 EHGNF-----TY--GTVVFYDCNPGYFLFGSSVLICQPNGQW-DKPLPECIMIDCGHPGV 2831
Query: 280 PINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWTEPPKCIEGQEKVACEE 338
P N+ + T+ G VH C + G + C+ +G W+ G C +
Sbjct: 2832 PPNAVLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 2889
Query: 339 PPFIENGA---ANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENN 393
P +G+ +N +K V YAC +GY+LHGS E TC G WT PEC
Sbjct: 2890 PGTPGHGSRQESNFRTK-----STVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA 2942
Query: 394 ENCKHPPVVMNGAV--ADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSPPVC 450
C +P NG V DG S SSV Y C E Y+L G + +C G WS
Sbjct: 2943 VQCGNPGTTANGKVFRIDGTTFS----SSVIYSCMEGYILSGPSVRQCTANGTWSG---T 2995
Query: 451 LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEV 510
L CT+ + + +Y + G + ++C+ GY +
Sbjct: 2996 LPNCTI-ISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSG 3054
Query: 511 KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-D 569
P C C +PP I +G + + D G S+ Y C + L C+ +
Sbjct: 3055 VMPTCRAV----TCPTPPQISNGRLEGTNFDW---GFSISYICSPGYELSFPAVLTCVGN 3107
Query: 570 GMWT------TPPLCLEPCTLSFTEMEKNNLLLKWDFD---NRPHILHGEYIEFICRGD 619
G W+ P C +P + + E + + + + N P IL G IC+ D
Sbjct: 3108 GTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR-ICQAD 3165
Score = 111 bits (277), Expect = 2e-24
Identities = 128/483 (26%), Positives = 196/483 (40%), Gaps = 59/483 (12%)
Query: 114 MRYGCASGYKTTGGKDEEVVQCLSDGWSSQ----PTCRKEHETCLAPEL-YNGNYSTTQK 168
+R+ C G++ G K V + S G+ + P C+ +C P+ NG TT
Sbjct: 2488 VRWACDRGFRLVG-KSSAVCRKSSYGYHAWDAPVPACQAI--SCGIPKAPTNGGILTTD- 2543
Query: 169 TFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS---LTPKCTKLKCSSLRLIENGYF 224
+ V +V Y C GY + + T V C + G WS TP+C + C L NG
Sbjct: 2544 -YLVGTRVTYFCNDGYRLSSKELTTAV-CQSDGTWSNHNKTPRCVVISCGELPTPPNGNK 2601
Query: 225 HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSK 284
+ +Y G F C + L GS + +C + G + ES C P L +N +
Sbjct: 2602 IGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESET-RCLAGHCGIPELIVNGQ 2658
Query: 285 IQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEEPPFI 342
+ + YR + V +C F + GS+ C +D W+ + P C+ V+C P
Sbjct: 2659 VIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCV----PVSCGHP--- 2709
Query: 343 ENGAANLHSKIYYNG----DKVTYACKSGYLLHGSNEITCNRGK-WTLPPECVENNENCK 397
+ ++ + NG D VT++C GYL+ G + C + W+ PP + NC
Sbjct: 2710 ---GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK-VVNCS 2765
Query: 398 HPPVVMNGAVADGI-LASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSP-PVCLEPC 454
P + N I ++ G+ V Y CN Y L GS + C+ G+W P P C
Sbjct: 2766 DPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC---- 2821
Query: 455 TVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC---NRGEVK 511
+ +D + K G + + C L L + S C
Sbjct: 2822 -IMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL-----LGQSSRTCQLNGHWSGS 2875
Query: 512 YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DG 570
P C+ ++ G C P HG S + S+V Y C + L GS E CL +G
Sbjct: 2876 QPHCS-GDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 2931
Query: 571 MWT 573
WT
Sbjct: 2932 SWT 2934
Score = 94.7 bits (234), Expect = 2e-19
Identities = 108/409 (26%), Positives = 165/409 (40%), Gaps = 37/409 (9%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
+ C GY E+ TC G W+ +P C +C P + NG + +
Sbjct: 2911 YACDTGYILHGS---EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGT-TFSS 2966
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
++ Y C GY +G V QC ++G WS P C +C P + N +
Sbjct: 2967 SVIYSCMEGYILSG---PSVRQCTANGTWSGTLPNCTII--SCGDPGI-PANGLRYGDDY 3020
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQ 229
V V Y C GY + WS + P C + C + I NG
Sbjct: 3021 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN- 3079
Query: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINSKIQTH 288
++ G + + C Y LS ++ C G W E P C + C P +P K +
Sbjct: 3080 -FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKF--CGDPGIPAQGKREGK 3136
Query: 289 STTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKVACEEPPFIENGA 346
S Y+ V C F + GS+ C+ DG W+ P CIE + +CE P +G+
Sbjct: 3137 SFIYQSE--VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ-TSCENPGVPRHGS 3193
Query: 347 ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWT-LPPECVENNENCKHPPVVMN 404
N ++ + G V + CK G+LL GS TC W+ + PEC+ + +CK P +
Sbjct: 3194 QN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPH--SCKQPETPAH 3250
Query: 405 GAVADGILASYATGSSVEYRCNEYYLLRGS---KISRCEQGKWSSPPVC 450
V L S+ G ++ Y C + L G ++ R + P+C
Sbjct: 3251 ANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3297
Score = 87.8 bits (216), Expect = 3e-17
Identities = 128/556 (23%), Positives = 190/556 (34%), Gaps = 110/556 (19%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQ 167
+ + + + C GY G QC ++ S P + C P + + ++
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGPTK---AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2778
Query: 168 ---KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKCSSLRLIENG 222
F V Y+C GY+ G + + C G W P+C + C + N
Sbjct: 2779 IEHGNFTYGTVVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA 2835
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEG-RRNRCPPPPLP 280
K T+ G V + C L G C N W P C G C P P
Sbjct: 2836 VLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP 2893
Query: 281 INSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEE 338
+ Q + +R V C+ + +HGS E C +G WT P+C + V C
Sbjct: 2894 GHGSRQ--ESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC----KAVQCGN 2947
Query: 339 PPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWT-LPPECVENNENC 396
P NG ++ V Y+C GY+L G + C G W+ P C + C
Sbjct: 2948 PGTTANGKVFRIDGTTFSSS-VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS--C 3004
Query: 397 KHPPVVMNGAVADGILASYATGSSVEYRCNEYYL--LRGSKISRCE-QGKWSSP-PVCLE 452
P + NG Y G +V Y C Y L GS+I C G WS P C
Sbjct: 3005 GDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRA 3061
Query: 453 PCTVNVDYMNRNNIE---MKWKYEGKVLHGDLIDFVCKQGYDLS---------------- 493
++ +E W + I ++C GY+LS
Sbjct: 3062 VTCPTPPQISNGRLEGTNFDWGFS--------ISYICSPGYELSFPAVLTCVGNGTWSGE 3113
Query: 494 -----------PLTPL------------SELSVQCNRGEVKYPLCTR------------- 517
P P SE+S CN + TR
Sbjct: 3114 VPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3173
Query: 518 ---KESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
+ ++ C +P + +HG + ++ GS V++ C H L+GS CL D W+
Sbjct: 3174 HCIEPTQTSCENPGVPRHGS--QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3231
Query: 574 ------TPPLCLEPCT 583
P C +P T
Sbjct: 3232 GIQPECIPHSCKQPET 3247
Score = 61.2 bits (147), Expect = 3e-09
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 30/303 (9%)
Query: 51 IDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS---PEPRCFKKCTKPDLSNGYISDVKL 106
+ + +S+ C GYT E + TCT G WS P R T P +SNG +
Sbjct: 3022 VGQNVSYMCQPGYTMELNGSRIR-TCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF 3080
Query: 107 LYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYS 164
+ ++ Y C+ GY+ + V+ C+ +G WS + P C + C P +
Sbjct: 3081 DWGF--SISYICSPGYELS---FPAVLTCVGNGTWSGEVPQCLPKF--CGDPGI-PAQGK 3132
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKC---TKLKCSSLRLI 219
K+F + +V + C + G C G WS +P C T+ C + +
Sbjct: 3133 REGKSFIYQSEVSFSCNFPFILVGSSTR---ICQADGTWSGSSPHCIEPTQTSCENPGVP 3189
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPP 278
+G + ++ G VVQF C + + L GS C + W P C + C P
Sbjct: 3190 RHGSQNNT-FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC--IPHSCKQPE 3246
Query: 279 LPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC--EDGKWTEPPKCIEGQEKVAC 336
P ++ + HG + C+ F + G E R D WT E K+
Sbjct: 3247 TPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILV 3305
Query: 337 EEP 339
++P
Sbjct: 3306 KDP 3308
Score = 50.1 bits (118), Expect = 7e-06
Identities = 77/320 (24%), Positives = 122/320 (38%), Gaps = 45/320 (14%)
Query: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGK-----WTEP-PKC 327
C P P + I + T + +V C+ F + G + C W P P C
Sbjct: 2465 CSTPESPPHGYIISQ-TGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2523
Query: 328 IEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC----NRGKW 383
+ ++C P NG + + Y G +VTY C GY L S E+T + G W
Sbjct: 2524 ----QAISCGIPKAPTNGG--ILTTDYLVGTRVTYFCNDGYRL-SSKELTTAVCQSDGTW 2576
Query: 384 T---LPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC- 439
+ P CV +C P NG G SY GS+ + C+ ++L GS + C
Sbjct: 2577 SNHNKTPRCVV--ISCGELPTPPNGNKI-GTQTSY--GSTAIFTCDLGFMLVGSAVRECL 2631
Query: 440 EQGKWS-SPPVCLE-PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTP 497
G WS S CL C + +N I + Y D + + C G+ L +
Sbjct: 2632 SSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYR------DTVVYQCNPGFRL--IGS 2683
Query: 498 LSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHH 557
+ Q + + P C C P +G ++ + + V + C +
Sbjct: 2684 SVRICQQDHNWSGQLPSCVPVS----CGHPGSPIYG---RTSGNGFNFNDVVTFSCNIGY 2736
Query: 558 FLEGSREAYC-LDGMWTTPP 576
++G +A C + W+ PP
Sbjct: 2737 LMQGPTKAQCQANRQWSHPP 2756
Score = 45.8 bits (107), Expect = 1e-04
Identities = 137/618 (22%), Positives = 206/618 (33%), Gaps = 133/618 (21%)
Query: 47 FPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG---WS-PEPRCFKKCTKPDLSNGYIS 102
F I L+F C +GY E + C G WS P PRC +C +N I
Sbjct: 1092 FNFGIGDTLTFSCSSGYRLEG---TSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1148
Query: 103 DVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGN 162
+ Y + + C + GK + S T L ++Y+G
Sbjct: 1149 -LSPNYPLNYENNHECIYSIQVQAGKGINI---------SARTFHLAQGDVL--KIYDGK 1196
Query: 163 YSTTQK--TFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLK-CSSLRLI 219
TT F ++ + + E G+ L +L C +
Sbjct: 1197 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1256
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF---GW-YPESPV---CEGR-- 270
+ GY Q + G + + C+ Y L GS L++C W YP C GR
Sbjct: 1257 QFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFK 1315
Query: 271 -----RNRCPPPPLPINSKIQTH-STTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 324
R P P P ++ ++ G IV ++ L F+ S +I W P
Sbjct: 1316 GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQF-LAFDTEASHDIL---RVWDGP 1371
Query: 325 PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWT 384
P E + I G + + + D Y KSG+ + S+ +
Sbjct: 1372 P---ENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA----- 1423
Query: 385 LPPECVENNENCKHPPVVMNGAV-ADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK 443
C+ P V MNG DG G +V ++C+ Y L+G + C Q +
Sbjct: 1424 -----------CRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE 1468
Query: 444 ----WS-SPPVCLEPC------------------------------TVNVDYM------- 461
W SPPVC+ PC TVN DY+
Sbjct: 1469 NRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFIS 1528
Query: 462 --NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC------NRGEVKYP 513
N + + Y+G + LI + S L E S + G V Y
Sbjct: 1529 FSIEPNYDFLYIYDGPDSNSPLIG-----SFQDSKLPERIESSSNTMHLAFRSDGSVSYT 1583
Query: 514 ---LCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG 570
L + + + C P I +G + Y+ GS+V Y C + L+G C+ G
Sbjct: 1584 GFHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAGYVLQGYSTLTCIMG 1640
Query: 571 MWTTP------PLCLEPC 582
P P C PC
Sbjct: 1641 DDGRPGWNRALPSCHAPC 1658
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/225 (23%), Positives = 78/225 (34%), Gaps = 64/225 (28%)
Query: 415 YATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWS-SPPVCLEPC----------TVNV 458
+A GSSV + CN Y+L GS RCE +W+ S P C+ PC ++
Sbjct: 1790 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1849
Query: 459 DYMN--RNNIEMKWKY---EGKVLHGDLIDFVCKQGYDLSP------------------- 494
Y NN+ WK EG + ++ F + +D
Sbjct: 1850 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1909
Query: 495 -------------LTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVD 541
L S++SV ++Y C P G+ I D
Sbjct: 1910 IPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI----GLDSCPEPQTPSSGIKIG---D 1962
Query: 542 TYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPC 582
Y G V ++C + L+G C+ G W P P+CL C
Sbjct: 1963 RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2007
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/215 (25%), Positives = 75/215 (34%), Gaps = 63/215 (29%)
Query: 234 GDVVQFFCHENYYLSGSDLIQC-YNFGWYPESPVCE---GRRNRCPP--------PPLPI 281
G V F C Y LS + + C N W P C+ G R P P
Sbjct: 925 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYP 984
Query: 282 NSKIQTHSTTYRHGEIVHIECE-LNFEIHGSAEIRCEDGKWTEPPKCIEGQE-------- 332
NS T + HG+ V + E H + E+G +T+P + G +
Sbjct: 985 NSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAG 1044
Query: 333 ------------------------------KVACEEPPFIENGAANLHSKIYYN---GDK 359
CE+P G S+I +N GD
Sbjct: 1045 LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP-----GIPQYGSRIGFNFGIGDT 1099
Query: 360 VTYACKSGYLLHGSNEITC---NRGKWTLP-PECV 390
+T++C SGY L G++EI C R W+ P P CV
Sbjct: 1100 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Score = 41.6 bits (96), Expect = 0.002
Identities = 91/427 (21%), Positives = 145/427 (33%), Gaps = 117/427 (27%)
Query: 272 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNF-EIHGSAEIRC--EDGK--WTEP-P 325
N CP P +PIN++ ++ G + + CE F + G+ I C DGK W+ P
Sbjct: 728 NECPDPGIPINAR--RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 785
Query: 326 KCIEG---------------------QEKVACEEPPFIENGAA----------------- 347
KC ++ + CE E G +
Sbjct: 786 KCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVL 845
Query: 348 ------NLHSKIY--YNGDKVTYACKSG----YLLHGSNEITCNRGKWTLPPECVENNEN 395
NL S + YNG +V S YLL ++ N G N +
Sbjct: 846 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 905
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV------ 449
C P + ++G ++ GS+V + C+ Y L + CE+ W S P+
Sbjct: 906 CLDPGIPVHGRRYGH---DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 962
Query: 450 -----------CLEP-----------CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCK 487
L P CT VD + ++ + H D + + +
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL-LITE 1021
Query: 488 QGYDLSPLTPL--SELSVQCNRG---------------EVKYP---LCTRKESKGMCTSP 527
G PL L S+L N G + Y + + + C P
Sbjct: 1022 NGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP 1081
Query: 528 PLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPCT 583
+ ++G I + G ++ + C + LEG+ E CL G +W+ P P C+ C
Sbjct: 1082 GIPQYGSRIGFN---FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1138
Query: 584 LSFTEME 590
S T E
Sbjct: 1139 ASATNNE 1145
Score = 40.8 bits (94), Expect = 0.004
Identities = 57/274 (20%), Positives = 97/274 (35%), Gaps = 57/274 (20%)
Query: 329 EGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-----NRGKW 383
E + +C P G L+ + GDK+ Y+C +GY+L G ++TC N W
Sbjct: 171 EELQSSSCGNPGVPPKGV--LYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASW 228
Query: 384 TLP--------------------------PECVENNENCKHPPVVMNGAVADGILASYAT 417
P P NN +C V G I +
Sbjct: 229 DFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQM 288
Query: 418 GSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNI-EMKWKYEGKV 476
+Y + GS+ + PP P N +++ + + + +Y G
Sbjct: 289 EEKY-----DYLEIEGSEPPTIWLSGMNIPP----PIISNKNWLRLHFVTDSNHRYRGFS 339
Query: 477 LHGDL---IDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHG 533
+ IDF +G+ L P S N G + K + +C P ++G
Sbjct: 340 APYQVKKAIDFK-SRGFKLFPGKDNSNKFSILNEGGI-------KTASNLCPDPGEPENG 391
Query: 534 VIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
I S + GS+V++ C + + L+G++ C
Sbjct: 392 KRIGS---DFSLGSTVQFSCDEDYVLQGAKSITC 422
Score = 38.9 bits (89), Expect = 0.015
Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 61/247 (24%)
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSS-PPV 449
C P NG I + ++ GS+V++ C+E Y+L+G+K C++ WS PV
Sbjct: 382 CPDPGEPENGK---RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 438
Query: 450 C-LEPC------------TVNVDYMNRNNIEMKWKY----EGKVLHGDLIDFVCKQGYDL 492
C ++ C + N + +N + W KV+ + +F + GYD
Sbjct: 439 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDT 498
Query: 493 ----------SPLTPLS--------------------ELSVQCNRGEVKYPLCTRKESKG 522
P T L L + G V + + ++ K
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 558
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTP-PLCLE 580
C P +G+ D + N + + C L G + C + W+ P+C+
Sbjct: 559 SCGDPGTPLYGI---REGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 615
Query: 581 PCTLSFT 587
PC +FT
Sbjct: 616 PCLSNFT 622
Score = 36.2 bits (82), Expect = 0.099
Identities = 53/265 (20%), Positives = 94/265 (35%), Gaps = 32/265 (12%)
Query: 202 WSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-- 259
+ P+ + +CSS+ E + + + G V F C+ Y L GS I+C
Sbjct: 1763 YQAVPRTSSTQCSSVP--EPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1820
Query: 260 ---WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC 316
W P C P + K S Y ++ C + A I+
Sbjct: 1821 LAQWNDSLPTCI-----VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQV 1875
Query: 317 EDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKS---GYLLHGS 373
+ + + + F + G N Y+G + + S L+
Sbjct: 1876 Q---------VVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQ 1926
Query: 374 NEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRG 433
++I+ + + L + ++C P +G I Y G V ++C++ Y L+G
Sbjct: 1927 SDISVSAAGFHLEYTAI-GLDSCPEPQTPSSGIK---IGDRYMVGDVVSFQCDQGYSLQG 1982
Query: 434 SKISRCEQG---KWSSP-PVCLEPC 454
C G +W+ P P+CL C
Sbjct: 1983 HSHITCMPGPVRRWNYPIPICLAQC 2007
Score = 36.2 bits (82), Expect = 0.099
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTE----PPKC 327
C PPP N++I T + G+I+ +C F + G+A + C G+ + PP C
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC 2348
Score = 34.3 bits (77), Expect = 0.38
Identities = 29/99 (29%), Positives = 39/99 (39%), Gaps = 18/99 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLP------PE 388
+C +P I NG Y G VTY C +GY+L G + +TC G P P
Sbjct: 1596 SCFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653
Query: 389 CVENNENCKHPPVVMNGAVADGILAS--YATGSSVEYRC 425
C H P ++G + S Y SV + C
Sbjct: 1654 C--------HAPCGSRSTGSEGTVLSPNYPKNYSVGHNC 1684
Score = 32.7 bits (73), Expect = 1.1
Identities = 54/259 (20%), Positives = 95/259 (36%), Gaps = 48/259 (18%)
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF-----GWYPESPVC------- 267
ENG + + G VQF C E+Y L G+ I C W PVC
Sbjct: 389 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGS 446
Query: 268 --EGRRNRCPPPPLPI----NSKIQTHSTTYRHGEIVHIEC-ELNFEIHGSAEIRCEDGK 320
+G P P N++ T +++ I E + EI G + DG
Sbjct: 447 NLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI-GYDTLTIGDGG 505
Query: 321 WTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
P+ + + F+ + ++ S+++ LH + +
Sbjct: 506 EVGDPRTV-----LQVLTGSFVPDLIVSMSSQMW---------------LHLQTDESVGS 545
Query: 381 GKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC- 439
+ + + +E E+C P + G + +G ++ + + C + L G K C
Sbjct: 546 VGFKVNYKEIE-KESCGDPGTPLYG-IREG--DGFSNRDVLRFECQFGFELIGEKSIVCQ 601
Query: 440 EQGKWSSP-PVCLEPCTVN 457
E +WS+ P+C+ PC N
Sbjct: 602 ENNQWSANIPICIFPCLSN 620
Score = 32.7 bits (73), Expect = 1.1
Identities = 63/293 (21%), Positives = 108/293 (36%), Gaps = 55/293 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTLP-PECV 390
+C +P NG + + G +++ C GY L G++ +TC G W P P C
Sbjct: 2119 SCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC- 2175
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGKWSSPP 448
C MNG + Y+ G EY + ++L+R PP
Sbjct: 2176 --EALCGGNITAMNGTI-------YSPGYPDEYPNFQDCFWLVR-------------VPP 2213
Query: 449 VCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG 508
N Y+N ++ + Y+ + D D Q S T L + N+
Sbjct: 2214 -------GNGIYINFTVLQTEPIYD-FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQI 2265
Query: 509 EVK----------YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
+K + L +C PP + + I++ D +E G + Y+C
Sbjct: 2266 LIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFT 2324
Query: 559 LEGSREAYCLDG----MWTTPPLCLEPCTLSFTEMEKNNLLLKWDF-DNRPHI 606
L G+ C G M PP+C C + ++ ++L + D+ P++
Sbjct: 2325 LVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNL 2377
Score = 31.2 bits (69), Expect = 3.2
Identities = 57/243 (23%), Positives = 86/243 (35%), Gaps = 44/243 (18%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECL-----TYGWSL-TPKC-TKLKCS-------- 214
F V DK++Y C TGY G ++ C+ T W P C + C
Sbjct: 194 FDVGDKIRYSCVTGYILDGHP---QLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSG 250
Query: 215 --SLRLIENGYFHPVKQTY----EEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCE 268
S N Y + T+ E GD + + D ++ E P
Sbjct: 251 IISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG----SEPPTIW 306
Query: 269 GRRNRCPPPPLPINSKIQTHSTT-----YRHGEIVH-IECELNFEIHGSAEIRCEDGKWT 322
PPP + + ++ H T YR + ++ ++F+ G + GK
Sbjct: 307 LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRG---FKLFPGKDN 363
Query: 323 EPPKCI--EGQEKVA---CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEIT 377
I EG K A C +P ENG + G V ++C Y+L G+ IT
Sbjct: 364 SNKFSILNEGGIKTASNLCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSIT 421
Query: 378 CNR 380
C R
Sbjct: 422 CQR 424
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 118 bits (295), Expect = 2e-26
Identities = 159/599 (26%), Positives = 231/599 (38%), Gaps = 83/599 (13%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
F C G+ E C + G WS E RC C P+L NG + Y ++
Sbjct: 2783 FTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN--YGYRD 2837
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSD-GWSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
+ Y C G++ G V C D WS Q P+C +Y T+ F
Sbjct: 2838 TVVYQCNPGFRLIGSS---VRICQQDHNWSGQLPSCVPVSCGHPGSPIYG---RTSGNGF 2891
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVEC-LTYGWSLTPK-CTKLKCSSLRL---------I 219
D V + C GY G K + C WS P C + CS + I
Sbjct: 2892 NFNDVVTFSCNIGYLMQGPTKAQ---CQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2948
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPL 279
E+G F TY G VV + C+ Y+L GS ++ C G + + P+ E C P +
Sbjct: 2949 EHGNF-----TY--GTVVFYDCNPGYFLFGSSVLICQPNGQW-DKPLPECIMIDCGHPGV 3000
Query: 280 PINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWTEPPKCIEGQEKVACEE 338
P N+ + T+ G VH C + G + C+ +G W+ G C +
Sbjct: 3001 PPNAVLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 3058
Query: 339 PPFIENGA---ANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWT-LPPECVENN 393
P +G+ +N +K V YAC +GY+LHGS E TC G WT PEC
Sbjct: 3059 PGTPGHGSRQESNFRTK-----STVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA 3111
Query: 394 ENCKHPPVVMNGAV--ADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSPPVC 450
C +P NG V DG S SSV Y C E Y+L G + +C G WS
Sbjct: 3112 VQCGNPGTTANGKVFRIDGTTFS----SSVIYSCMEGYILSGPSVRQCTANGTWSG---T 3164
Query: 451 LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEV 510
L CT+ + + +Y + G + ++C+ GY +
Sbjct: 3165 LPNCTI-ISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSG 3223
Query: 511 KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-D 569
P C C +PP I +G + + D G S+ Y C + L C+ +
Sbjct: 3224 VMPTCRAV----TCPTPPQISNGRLEGTNFDW---GFSISYICSPGYELSFPAVLTCVGN 3276
Query: 570 GMWT------TPPLCLEPCTLSFTEMEKNNLLLKWDFD---NRPHILHGEYIEFICRGD 619
G W+ P C +P + + E + + + + N P IL G IC+ D
Sbjct: 3277 GTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTR-ICQAD 3334
Score = 115 bits (288), Expect = 1e-25
Identities = 129/490 (26%), Positives = 198/490 (40%), Gaps = 58/490 (11%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPE---LYNGN 162
Y + + Y C GY+ + K+ C SDG WS+ T R TC + L +G
Sbjct: 2648 YLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2706
Query: 163 YSTTQKT-FKVKDKVQYECATGYYTAGGKKTEEVECL---TYGW-SLTPKCTKLKCSSLR 217
+ + ++ K KV + C GY+ G +ECL T+ W + P C + C L
Sbjct: 2707 WRIVNGSHYEYKTKVVFSCDPGYHGLG---PASIECLPNGTWSWRNERPYCQIISCGELP 2763
Query: 218 LIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
NG + +Y G F C + L GS + +C + G + ES C P
Sbjct: 2764 TPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESET-RCLAGHCGIP 2820
Query: 278 PLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVA 335
L +N ++ + YR + V +C F + GS+ C +D W+ + P C+ V+
Sbjct: 2821 ELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCV----PVS 2874
Query: 336 CEEPPFIENGAANLHSKIYYNG----DKVTYACKSGYLLHGSNEITCNRGK-WTLPPECV 390
C P + ++ + NG D VT++C GYL+ G + C + W+ PP
Sbjct: 2875 CGHP------GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2928
Query: 391 ENNENCKHPPVVMNGAVADGI-LASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSP- 447
+ NC P + N I ++ G+ V Y CN Y L GS + C+ G+W P
Sbjct: 2929 K-VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPL 2987
Query: 448 PVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-- 505
P C + +D + K G + + C L L + S C
Sbjct: 2988 PEC-----IMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL-----LGQSSRTCQL 3037
Query: 506 -NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSRE 564
P C+ ++ G C P HG S + S+V Y C + L GS E
Sbjct: 3038 NGHWSGSQPHCS-GDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEE 3093
Query: 565 AYCL-DGMWT 573
CL +G WT
Sbjct: 3094 RTCLANGSWT 3103
Score = 94.7 bits (234), Expect = 2e-19
Identities = 108/409 (26%), Positives = 165/409 (40%), Gaps = 37/409 (9%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WSP-EPRCFK-KCTKPDLS-NGYISDVKLLYKIQE 112
+ C GY E+ TC G W+ +P C +C P + NG + +
Sbjct: 3080 YACDTGYILHGS---EERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGT-TFSS 3135
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTTQKTF 170
++ Y C GY +G V QC ++G WS P C +C P + N +
Sbjct: 3136 SVIYSCMEGYILSG---PSVRQCTANGTWSGTLPNCTII--SCGDPGI-PANGLRYGDDY 3189
Query: 171 KVKDKVQYECATGYYTAGGKKTEEVECLTYGWS-LTPKCTKLKCSSLRLIENGYFHPVKQ 229
V V Y C GY + WS + P C + C + I NG
Sbjct: 3190 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN- 3248
Query: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINSKIQTH 288
++ G + + C Y LS ++ C G W E P C + C P +P K +
Sbjct: 3249 -FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKF--CGDPGIPAQGKREGK 3305
Query: 289 STTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKVACEEPPFIENGA 346
S Y+ V C F + GS+ C+ DG W+ P CIE + +CE P +G+
Sbjct: 3306 SFIYQSE--VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ-TSCENPGVPRHGS 3362
Query: 347 ANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWT-LPPECVENNENCKHPPVVMN 404
N ++ + G V + CK G+LL GS TC W+ + PEC+ + +CK P +
Sbjct: 3363 QN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPH--SCKQPETPAH 3419
Query: 405 GAVADGILASYATGSSVEYRCNEYYLLRGS---KISRCEQGKWSSPPVC 450
V L S+ G ++ Y C + L G ++ R + P+C
Sbjct: 3420 ANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3466
Score = 87.8 bits (216), Expect = 3e-17
Identities = 128/556 (23%), Positives = 190/556 (34%), Gaps = 110/556 (19%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQ 167
+ + + + C GY G QC ++ S P + C P + + ++
Sbjct: 2891 FNFNDVVTFSCNIGYLMQGPTK---AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2947
Query: 168 ---KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKCSSLRLIENG 222
F V Y+C GY+ G + + C G W P+C + C + N
Sbjct: 2948 IEHGNFTYGTVVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA 3004
Query: 223 YFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEG-RRNRCPPPPLP 280
K T+ G V + C L G C N W P C G C P P
Sbjct: 3005 VLSGEKYTF--GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP 3062
Query: 281 INSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEE 338
+ Q + +R V C+ + +HGS E C +G WT P+C + V C
Sbjct: 3063 GHGSRQ--ESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC----KAVQCGN 3116
Query: 339 PPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWT-LPPECVENNENC 396
P NG ++ V Y+C GY+L G + C G W+ P C + C
Sbjct: 3117 PGTTANGKVFRIDGTTFSSS-VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS--C 3173
Query: 397 KHPPVVMNGAVADGILASYATGSSVEYRCNEYYL--LRGSKISRCE-QGKWSSP-PVCLE 452
P + NG Y G +V Y C Y L GS+I C G WS P C
Sbjct: 3174 GDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRA 3230
Query: 453 PCTVNVDYMNRNNIE---MKWKYEGKVLHGDLIDFVCKQGYDLS---------------- 493
++ +E W + I ++C GY+LS
Sbjct: 3231 VTCPTPPQISNGRLEGTNFDWGFS--------ISYICSPGYELSFPAVLTCVGNGTWSGE 3282
Query: 494 -----------PLTPL------------SELSVQCNRGEVKYPLCTR------------- 517
P P SE+S CN + TR
Sbjct: 3283 VPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3342
Query: 518 ---KESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
+ ++ C +P + +HG + ++ GS V++ C H L+GS CL D W+
Sbjct: 3343 HCIEPTQTSCENPGVPRHGS--QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3400
Query: 574 ------TPPLCLEPCT 583
P C +P T
Sbjct: 3401 GIQPECIPHSCKQPET 3416
Score = 61.2 bits (147), Expect = 3e-09
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 30/303 (9%)
Query: 51 IDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS---PEPRCFKKCTKPDLSNGYISDVKL 106
+ + +S+ C GYT E + TCT G WS P R T P +SNG +
Sbjct: 3191 VGQNVSYMCQPGYTMELNGSRIR-TCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF 3249
Query: 107 LYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYS 164
+ ++ Y C+ GY+ + V+ C+ +G WS + P C + C P +
Sbjct: 3250 DWGF--SISYICSPGYELS---FPAVLTCVGNGTWSGEVPQCLPKF--CGDPGI-PAQGK 3301
Query: 165 TTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKC---TKLKCSSLRLI 219
K+F + +V + C + G C G WS +P C T+ C + +
Sbjct: 3302 REGKSFIYQSEVSFSCNFPFILVGSSTR---ICQADGTWSGSSPHCIEPTQTSCENPGVP 3358
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPP 278
+G + ++ G VVQF C + + L GS C + W P C + C P
Sbjct: 3359 RHGSQNNT-FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC--IPHSCKQPE 3415
Query: 279 LPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC--EDGKWTEPPKCIEGQEKVAC 336
P ++ + HG + C+ F + G E R D WT E K+
Sbjct: 3416 TPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILV 3474
Query: 337 EEP 339
++P
Sbjct: 3475 KDP 3477
Score = 45.8 bits (107), Expect = 1e-04
Identities = 137/618 (22%), Positives = 206/618 (33%), Gaps = 133/618 (21%)
Query: 47 FPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEG---WS-PEPRCFKKCTKPDLSNGYIS 102
F I L+F C +GY E + C G WS P PRC +C +N I
Sbjct: 1196 FNFGIGDTLTFSCSSGYRLEG---TSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1252
Query: 103 DVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGN 162
+ Y + + C + GK + S T L ++Y+G
Sbjct: 1253 -LSPNYPLNYENNHECIYSIQVQAGKGINI---------SARTFHLAQGDVL--KIYDGK 1300
Query: 163 YSTTQK--TFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLK-CSSLRLI 219
TT F ++ + + E G+ L +L C +
Sbjct: 1301 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1360
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF---GW-YPESPV---CEGR-- 270
+ GY Q + G + + C+ Y L GS L++C W YP C GR
Sbjct: 1361 QFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFK 1419
Query: 271 -----RNRCPPPPLPINSKIQTH-STTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 324
R P P P ++ ++ G IV ++ L F+ S +I W P
Sbjct: 1420 GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQF-LAFDTEASHDIL---RVWDGP 1475
Query: 325 PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWT 384
P E + I G + + + D Y KSG+ + S+ +
Sbjct: 1476 P---ENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA----- 1527
Query: 385 LPPECVENNENCKHPPVVMNGAV-ADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK 443
C+ P V MNG DG G +V ++C+ Y L+G + C Q +
Sbjct: 1528 -----------CRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE 1572
Query: 444 ----WS-SPPVCLEPC------------------------------TVNVDYM------- 461
W SPPVC+ PC TVN DY+
Sbjct: 1573 NRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFIS 1632
Query: 462 --NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC------NRGEVKYP 513
N + + Y+G + LI + S L E S + G V Y
Sbjct: 1633 FSIEPNYDFLYIYDGPDSNSPLIG-----SFQDSKLPERIESSSNTMHLAFRSDGSVSYT 1687
Query: 514 ---LCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG 570
L + + + C P I +G + Y+ GS+V Y C + L+G C+ G
Sbjct: 1688 GFHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAGYVLQGYSTLTCIMG 1744
Query: 571 MWTTP------PLCLEPC 582
P P C PC
Sbjct: 1745 DDGRPGWNRALPSCHAPC 1762
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/225 (23%), Positives = 78/225 (34%), Gaps = 64/225 (28%)
Query: 415 YATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWS-SPPVCLEPC----------TVNV 458
+A GSSV + CN Y+L GS RCE +W+ S P C+ PC ++
Sbjct: 1894 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSP 1953
Query: 459 DYMN--RNNIEMKWKY---EGKVLHGDLIDFVCKQGYDLSP------------------- 494
Y NN+ WK EG + ++ F + +D
Sbjct: 1954 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 2013
Query: 495 -------------LTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVD 541
L S++SV ++Y C P G+ I D
Sbjct: 2014 IPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI----GLDSCPEPQTPSSGIKIG---D 2066
Query: 542 TYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPC 582
Y G V ++C + L+G C+ G W P P+CL C
Sbjct: 2067 RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2111
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/215 (25%), Positives = 75/215 (34%), Gaps = 63/215 (29%)
Query: 234 GDVVQFFCHENYYLSGSDLIQC-YNFGWYPESPVCE---GRRNRCPP--------PPLPI 281
G V F C Y LS + + C N W P C+ G R P P
Sbjct: 1029 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYP 1088
Query: 282 NSKIQTHSTTYRHGEIVHIECE-LNFEIHGSAEIRCEDGKWTEPPKCIEGQE-------- 332
NS T + HG+ V + E H + E+G +T+P + G +
Sbjct: 1089 NSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAG 1148
Query: 333 ------------------------------KVACEEPPFIENGAANLHSKIYYN---GDK 359
CE+P G S+I +N GD
Sbjct: 1149 LYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP-----GIPQYGSRIGFNFGIGDT 1203
Query: 360 VTYACKSGYLLHGSNEITC---NRGKWTLP-PECV 390
+T++C SGY L G++EI C R W+ P P CV
Sbjct: 1204 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Score = 41.6 bits (96), Expect = 0.002
Identities = 91/427 (21%), Positives = 145/427 (33%), Gaps = 117/427 (27%)
Query: 272 NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNF-EIHGSAEIRC--EDGK--WTEP-P 325
N CP P +PIN++ ++ G + + CE F + G+ I C DGK W+ P
Sbjct: 832 NECPDPGIPINAR--RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 889
Query: 326 KCIEG---------------------QEKVACEEPPFIENGAA----------------- 347
KC ++ + CE E G +
Sbjct: 890 KCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVL 949
Query: 348 ------NLHSKIY--YNGDKVTYACKSG----YLLHGSNEITCNRGKWTLPPECVENNEN 395
NL S + YNG +V S YLL ++ N G N +
Sbjct: 950 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 1009
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV------ 449
C P + ++G ++ GS+V + C+ Y L + CE+ W S P+
Sbjct: 1010 CLDPGIPVHGRRYGH---DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1066
Query: 450 -----------CLEP-----------CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCK 487
L P CT VD + ++ + H D + + +
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL-LITE 1125
Query: 488 QGYDLSPLTPL--SELSVQCNRG---------------EVKYP---LCTRKESKGMCTSP 527
G PL L S+L N G + Y + + + C P
Sbjct: 1126 NGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDP 1185
Query: 528 PLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPCT 583
+ ++G I + G ++ + C + LEG+ E CL G +W+ P P C+ C
Sbjct: 1186 GIPQYGSRIGFN---FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1242
Query: 584 LSFTEME 590
S T E
Sbjct: 1243 ASATNNE 1249
Score = 40.0 bits (92), Expect = 0.007
Identities = 54/231 (23%), Positives = 86/231 (37%), Gaps = 33/231 (14%)
Query: 360 VTYACKSGYLLHGSNEITCNRGK-----WTLP-PECVENNENCKHPPVVMNGAVADGILA 413
V +AC G+ L G + C + W P P C +C P NG + +
Sbjct: 2592 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC--QAISCGIPKAPTNGGI---LTT 2646
Query: 414 SYATGSSVEYRCNEYYLLRGSKISRC---EQGKWSSPPVCLEPCTVNVDYMNRNNIEM-K 469
Y G+ V Y CN+ Y L +++ G WS+ V +N +E +
Sbjct: 2647 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2706
Query: 470 WKYEGKVLHGDLIDFVCKQGYDLSP-LTPLSELSVQCNRGEV-----KYPLCTRKESKGM 523
W ++++G ++ K + P L S++C + P C +
Sbjct: 2707 W----RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGEL 2762
Query: 524 CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
T P K G T +Y GS+ + C L GS CL G+W+
Sbjct: 2763 PTPPNGNKIG-----TQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWS 2806
Score = 38.9 bits (89), Expect = 0.015
Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 61/247 (24%)
Query: 396 CKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSS-PPV 449
C P NG I + ++ GS+V++ C+E Y+L+G+K C++ WS PV
Sbjct: 486 CPDPGEPENGK---RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542
Query: 450 C-LEPC------------TVNVDYMNRNNIEMKWKY----EGKVLHGDLIDFVCKQGYDL 492
C ++ C + N + +N + W KV+ + +F + GYD
Sbjct: 543 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDT 602
Query: 493 ----------SPLTPLS--------------------ELSVQCNRGEVKYPLCTRKESKG 522
P T L L + G V + + ++ K
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 662
Query: 523 MCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTP-PLCLE 580
C P +G+ D + N + + C L G + C + W+ P+C+
Sbjct: 663 SCGDPGTPLYGI---REGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 719
Query: 581 PCTLSFT 587
PC +FT
Sbjct: 720 PCLSNFT 726
Score = 36.6 bits (83), Expect = 0.076
Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 7/73 (9%)
Query: 329 EGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-----NRGKW 383
E + +C P G L+ + GDK+ Y+C +GY+L G ++TC N W
Sbjct: 171 EELQSSSCGNPGVPPKGV--LYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASW 228
Query: 384 TLPPECVENNENC 396
P + C
Sbjct: 229 DFPVPICRAEDAC 241
Score = 36.2 bits (82), Expect = 0.099
Identities = 53/265 (20%), Positives = 94/265 (35%), Gaps = 32/265 (12%)
Query: 202 WSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-- 259
+ P+ + +CSS+ E + + + G V F C+ Y L GS I+C
Sbjct: 1867 YQAVPRTSSTQCSSVP--EPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1924
Query: 260 ---WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC 316
W P C P + K S Y ++ C + A I+
Sbjct: 1925 LAQWNDSLPTCI-----VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQV 1979
Query: 317 EDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKS---GYLLHGS 373
+ + + + F + G N Y+G + + S L+
Sbjct: 1980 Q---------VVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQ 2030
Query: 374 NEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRG 433
++I+ + + L + ++C P +G I Y G V ++C++ Y L+G
Sbjct: 2031 SDISVSAAGFHLEYTAI-GLDSCPEPQTPSSGIK---IGDRYMVGDVVSFQCDQGYSLQG 2086
Query: 434 SKISRCEQG---KWSSP-PVCLEPC 454
C G +W+ P P+CL C
Sbjct: 2087 HSHITCMPGPVRRWNYPIPICLAQC 2111
Score = 36.2 bits (82), Expect = 0.099
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTE----PPKC 327
C PPP N++I T + G+I+ +C F + G+A + C G+ + PP C
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC 2452
Score = 34.3 bits (77), Expect = 0.38
Identities = 29/99 (29%), Positives = 39/99 (39%), Gaps = 18/99 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLP------PE 388
+C +P I NG Y G VTY C +GY+L G + +TC G P P
Sbjct: 1700 SCFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757
Query: 389 CVENNENCKHPPVVMNGAVADGILAS--YATGSSVEYRC 425
C H P ++G + S Y SV + C
Sbjct: 1758 C--------HAPCGSRSTGSEGTVLSPNYPKNYSVGHNC 1788
Score = 32.7 bits (73), Expect = 1.1
Identities = 54/259 (20%), Positives = 95/259 (36%), Gaps = 48/259 (18%)
Query: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF-----GWYPESPVC------- 267
ENG + + G VQF C E+Y L G+ I C W PVC
Sbjct: 493 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGS 550
Query: 268 --EGRRNRCPPPPLPI----NSKIQTHSTTYRHGEIVHIEC-ELNFEIHGSAEIRCEDGK 320
+G P P N++ T +++ I E + EI G + DG
Sbjct: 551 NLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI-GYDTLTIGDGG 609
Query: 321 WTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
P+ + + F+ + ++ S+++ LH + +
Sbjct: 610 EVGDPRTV-----LQVLTGSFVPDLIVSMSSQMW---------------LHLQTDESVGS 649
Query: 381 GKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC- 439
+ + + +E E+C P + G + +G ++ + + C + L G K C
Sbjct: 650 VGFKVNYKEIE-KESCGDPGTPLYG-IREG--DGFSNRDVLRFECQFGFELIGEKSIVCQ 705
Query: 440 EQGKWSSP-PVCLEPCTVN 457
E +WS+ P+C+ PC N
Sbjct: 706 ENNQWSANIPICIFPCLSN 724
Score = 32.7 bits (73), Expect = 1.1
Identities = 63/293 (21%), Positives = 108/293 (36%), Gaps = 55/293 (18%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTLP-PECV 390
+C +P NG + + G +++ C GY L G++ +TC G W P P C
Sbjct: 2223 SCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC- 2279
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGKWSSPP 448
C MNG + Y+ G EY + ++L+R PP
Sbjct: 2280 --EALCGGNITAMNGTI-------YSPGYPDEYPNFQDCFWLVR-------------VPP 2317
Query: 449 VCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG 508
N Y+N ++ + Y+ + D D Q S T L + N+
Sbjct: 2318 -------GNGIYINFTVLQTEPIYD-FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQI 2369
Query: 509 EVK----------YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF 558
+K + L +C PP + + I++ D +E G + Y+C
Sbjct: 2370 LIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFT 2428
Query: 559 LEGSREAYCLDG----MWTTPPLCLEPCTLSFTEMEKNNLLLKWDF-DNRPHI 606
L G+ C G M PP+C C + ++ ++L + D+ P++
Sbjct: 2429 LVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNL 2481
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 5/55 (9%)
Query: 329 EGQEKVA---CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
EG K A C +P ENG + G V ++C Y+L G+ ITC R
Sbjct: 476 EGGIKTASNLCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQR 528
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 114 bits (286), Expect = 2e-25
Identities = 115/439 (26%), Positives = 179/439 (40%), Gaps = 53/439 (12%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYG-W-SLTPKCTKLKCSSLRLIENGYFHPV 227
F + + YEC GY + + CL W S KC + C + NG H +
Sbjct: 55 FPIGTYLNYECRPGY----SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVI 110
Query: 228 KQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINS 283
K + ++ C + Y L GS C G W ++PVC+ R C PP N
Sbjct: 111 KDIQFRSQI-KYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD--RIICGLPPTIANG 167
Query: 284 KIQTHSTTYRH-GEIVHIECELN------FEIHGSAEIRCED-----GKWTEP-PKCIEG 330
+ S Y H G +V C L FE+ G I C G W+ P P+CI
Sbjct: 168 DFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIP 227
Query: 331 QEKVACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHGSNEITCNR-GKWTLPPE 388
+ PP +ENG ++ ++ + V + C+ G+ + G + + C KW PE
Sbjct: 228 NKCT----PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWE--PE 281
Query: 389 CVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWS-S 446
+ C+ PP V++ +++ G V Y C Y LRGS C QG WS +
Sbjct: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPA 341
Query: 447 PPVC-LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTP-LSELSVQ 504
P C ++ C + + ++ + G +DFVC +G+ L + L+
Sbjct: 342 APRCEVKSCDDFLGQLPNGHVLFPLNLQ----LGAKVDFVCDEGFQLKGSSASYCVLAGM 397
Query: 505 CNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSRE 564
+ P+C RK C +PP+ +G++ + GS + Y C H L G
Sbjct: 398 ESLWNSSVPVCERKS----CETPPVPVNGMV--HVITDIHVGSRINYSCTTGHRLIGHSS 451
Query: 565 AYCL----DGMWT-TPPLC 578
A C+ W+ PP+C
Sbjct: 452 AECILSGNTAHWSMKPPIC 470
Score = 104 bits (259), Expect = 3e-22
Identities = 115/487 (23%), Positives = 190/487 (39%), Gaps = 72/487 (14%)
Query: 108 YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQ 167
+ I + Y C GY G+ ++ + W+S K P+ NG +
Sbjct: 55 FPIGTYLNYECRPGYS---GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG-MAHVI 110
Query: 168 KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG----W-SLTPKCTKLKCSSLRLIENG 222
K + + +++Y C GY G + C+ G W + TP C ++ C I NG
Sbjct: 111 KDIQFRSQIKYSCPKGYRLIG---SSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANG 167
Query: 223 YFHPVKQTY-EEGDVVQFFCH------ENYYLSGSDLIQCYNFG-----WYPESPVCEGR 270
F + + Y G VV + C+ + + L G I C + W +P C
Sbjct: 168 DFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCI-I 226
Query: 271 RNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED-GKW-TEPPKCI 328
N+C PP + + + + + E+V C+ F + G + ++C+ KW E P C
Sbjct: 227 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCS 286
Query: 329 EGQEKVACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHGSNEITCN-RGKWTLP 386
C+ PP + + K ++ G +V Y+C+ GY L GS + C +G W+
Sbjct: 287 R-----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPA 341
Query: 387 PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC----EQG 442
E + NG V + + G+ V++ C+E + L+GS S C +
Sbjct: 342 APRCEVKSCDDFLGQLPNGHVLFPL--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 399
Query: 443 KW-SSPPVC------LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
W SS PVC P VN +I + G I++ C G+ L
Sbjct: 400 LWNSSVPVCERKSCETPPVPVNGMVHVITDIHV----------GSRINYSCTTGHRL--- 446
Query: 496 TPLSELSVQC------NRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSV 549
+ S +C +K P+C + C +PP I +G + + G V
Sbjct: 447 --IGHSSAECILSGNTAHWSMKPPIC----QQIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
Query: 550 EYRCFDH 556
Y C H
Sbjct: 501 SYTCDPH 507
Score = 91.7 bits (226), Expect = 2e-18
Identities = 98/345 (28%), Positives = 141/345 (40%), Gaps = 56/345 (16%)
Query: 81 WS-PEPRCF--KKCTKPDLSNG-YISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCL 136
WS P P+C KCT P++ NG +SD + L+ + E + + C G+ G K V+C
Sbjct: 217 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF---GMKGPSHVKCQ 273
Query: 137 S-DGWSSQ-PTCRKEHETCLAPE--LYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKT 192
+ + W + P+C + C P L+ + F +V Y C GY G +
Sbjct: 274 ALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG---S 327
Query: 193 EEVECLTYG-WS-LTPKCTKLKCSS-LRLIENGY-FHPVKQTYEEGDVVQFFCHENYYLS 248
+ C G WS P+C C L + NG+ P+ + G V F C E + L
Sbjct: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL--NLQLGAKVDFVCDEGFQLK 385
Query: 249 GSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH-GEIVHIECE 303
GS C G W PVCE R C PP+P+N + H T H G ++ C
Sbjct: 386 GSSASYCVLAGMESLWNSSVPVCE--RKSCETPPVPVNGMV--HVITDIHVGSRINYSCT 441
Query: 304 LNFEIHGSAEIRC----EDGKWT-EPPKCIEGQEKVACEEPPFIENG--AANLHSKIYYN 356
+ G + C W+ +PP C +++ C PP I NG I Y
Sbjct: 442 TGHRLIGHSSAECILSGNTAHWSMKPPIC----QQIFCPNPPAILNGRHTGTPLGDIPY- 496
Query: 357 GDKVTYAC----KSGYLLHGSNEITCNR-------GKWTLP-PEC 389
G +V+Y C G + E T R G W+ P P C
Sbjct: 497 GKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
Score = 74.7 bits (182), Expect = 3e-13
Identities = 84/345 (24%), Positives = 135/345 (39%), Gaps = 47/345 (13%)
Query: 295 GEIVHIECELNFEIHGSAEIRCEDGKWTEPP-KCIEGQEKVACEEPPFIENGAANLHSKI 353
G ++ EC + + I ++ WT KC ++ +C PP NG A++ I
Sbjct: 58 GTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKC----KRKSCRNPPDPVNGMAHVIKDI 113
Query: 354 YYNGDKVTYACKSGYLLHGSNEITC----NRGKW-TLPPECVENNENCKHPPVVMNGAVA 408
+ ++ Y+C GY L GS+ TC N W P C + C PP + NG
Sbjct: 114 QFRS-QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC--DRIICGLPPTIANGDFT 170
Query: 409 DGILASYATGSSVEYRCN------EYYLLRGSKISRC-----EQGKWSSP-PVCLEP--C 454
+ GS V Y CN + + L G C + G WS P P C+ P C
Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
Query: 455 TVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPL 514
T N N + ++++F C+ G+ + P N+ E + P
Sbjct: 231 TPP----NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG--PSHVKCQALNKWEPELPS 284
Query: 515 CTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
C+R +C PP + H D + G V Y C + L GS +C G W+
Sbjct: 285 CSR-----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWS 339
Query: 574 -TPPLC-LEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFIC 616
P C ++ C ++ ++L ++ G ++F+C
Sbjct: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPL------NLQLGAKVDFVC 378
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 113 bits (282), Expect = 6e-25
Identities = 82/259 (31%), Positives = 122/259 (47%), Gaps = 24/259 (9%)
Query: 152 TCLAPELYNGNYSTTQKTF-KVKDKVQYECATGYYTAGGKKTEEVECLTYGWSL-TPKCT 209
TC P+ + KTF + +++ Y C GY + GG + + + LT W + T KCT
Sbjct: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMR-KFICPLTGLWPINTLKCT 80
Query: 210 KLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCE 268
C ++ENG T+E + + F C+ +YL+G+D +C G W PE PVC
Sbjct: 81 PRVCPFAGILENGAVRYT--TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCA 138
Query: 269 GRRNRCPPPPLPINSKIQTHSTTYRHGEIVH----IECELNFEIHGSAEIRCED-GKWTE 323
CPPP +P + ++ + + + + EC + G+ I C G WT+
Sbjct: 139 PII--CPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTK 196
Query: 324 PPKCIEGQEKVACEEPPFIENGAANLHSK--IYYNGDKVTYACKSGYLLHGSNEITCNR- 380
P+C E V C P +NG N +K +YY DK T+ C GY L G EI C +
Sbjct: 197 LPECRE----VKCPFPSRPDNGFVNYPAKPTLYYK-DKATFGCHDGYSLDGPEEIECTKL 251
Query: 381 GKWTLPPECVENNENCKHP 399
G W+ P C +CK P
Sbjct: 252 GNWSAMPSC---KASCKVP 267
Score = 92.4 bits (228), Expect = 1e-18
Identities = 76/311 (24%), Positives = 123/311 (39%), Gaps = 32/311 (10%)
Query: 226 PVKQTYEEGDVVQFFCHENYYLSGS-DLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSK 284
P+K YE G+ + + C Y G C G +P + + +C P P
Sbjct: 36 PLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTL------KCTPRVCPFAGI 89
Query: 285 IQTHS---TTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKCIEGQEKVACEEP 339
++ + TT+ + + C F ++G+ +C E+GKW+ E P C + C P
Sbjct: 90 LENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAP----IICPPP 145
Query: 340 PFIENGAANLHSKIYYNG----DKVTYACKSGYLLHGSNEITCN-RGKWTLPPECVENNE 394
++ N D + C + + G++ ITC G WT PEC E
Sbjct: 146 SIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECRE--V 203
Query: 395 NCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-GKWSSPPVCLEP 453
C P NG V + + C++ Y L G + C + G WS+ P C
Sbjct: 204 KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKAS 263
Query: 454 CTVNVD----YMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE 509
C V V ++++ K++ +LHGD + F CK T QC G
Sbjct: 264 CKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTE----DAQCIDGT 319
Query: 510 VKYPLCTRKES 520
++ P C ++ S
Sbjct: 320 IEVPKCFKEHS 330
Score = 73.2 bits (178), Expect = 7e-13
Identities = 74/292 (25%), Positives = 114/292 (39%), Gaps = 24/292 (8%)
Query: 89 KKCTKPD-LSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCR 147
+ C KPD L + +K Y+ E + Y C GY + GG + + C G T +
Sbjct: 21 RTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFI--CPLTGLWPINTLK 78
Query: 148 KEHETC-LAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-L 204
C A L NG T TF+ + + + C TG+Y G + +C G WS
Sbjct: 79 CTPRVCPFAGILENGAVRYT--TFEYPNTISFSCNTGFYLNG---ADSAKCTEEGKWSPE 133
Query: 205 TPKCTKLKCSSLRLIENGYFHPVKQTYEEG----DVVQFFCHENYYLSGSDLIQCYNFGW 260
P C + C + K + D F C + + G+D I C G
Sbjct: 134 LPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGN 193
Query: 261 YPESPVCEGRRNRCPPPPLPINSKIQ-THSTTYRHGEIVHIECELNFEIHGSAEIRCED- 318
+ + P C R +CP P P N + T + + C + + G EI C
Sbjct: 194 WTKLPEC--REVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKL 251
Query: 319 GKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYN----GDKVTYACKS 366
G W+ P C + KV ++ + G + + N GDKV++ CK+
Sbjct: 252 GNWSAMPSC-KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKN 302
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/324 (22%), Positives = 128/324 (39%), Gaps = 52/324 (16%)
Query: 354 YYNGDKVTYACKSGYLLHGS-NEITCN-RGKWTLPP-ECVENNENCKHPPVVMNGAVADG 410
Y G+++TY+CK GY+ G + C G W + +C C ++ NGAV
Sbjct: 41 YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRV--CPFAGILENGAVR-- 96
Query: 411 ILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWS------SPPVCLEP-----CTVNV 458
++ +++ + CN + L G+ ++C E+GKWS +P +C P T+ V
Sbjct: 97 -YTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRV 155
Query: 459 DYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR--GEVKYPLCT 516
+ N L+ D F C + + ++ C K P C
Sbjct: 156 YKPSAGN---------NSLYRDTAVFECLPQHAM-----FGNDTITCTTHGNWTKLPEC- 200
Query: 517 RKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-GMWTTP 575
+E K C P +G + T + C D + L+G E C G W+
Sbjct: 201 -REVK--CPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM 257
Query: 576 PLCLEPCTLSFTEM----EKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSI 631
P C C + + + + ++ F N +LHG+ + F C+ Y +
Sbjct: 258 PSCKASCKVPVKKATVVYQGERVKIQEKFKNG--MLHGDKVSFFCKNKEKKCS-YTEDA- 313
Query: 632 LRMQCDRGQLKYPRCIPRQSTLSY 655
QC G ++ P+C S+L++
Sbjct: 314 ---QCIDGTIEVPKCFKEHSSLAF 334
Score = 66.2 bits (160), Expect = 9e-11
Identities = 78/319 (24%), Positives = 127/319 (39%), Gaps = 61/319 (19%)
Query: 43 KSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPD------L 96
K+FY P +++++ C GY + G ++ C G P KCT L
Sbjct: 38 KTFYEP---GEEITYSCKPGYVSRGGMRK--FICPLTGLWPINTL--KCTPRVCPFAGIL 90
Query: 97 SNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCL 154
NG + Y + + C +G+ G + +C +G WS + P C C
Sbjct: 91 ENGAVRYTTFEYP--NTISFSCNTGFYLNGA---DSAKCTEEGKWSPELPVCAPI--ICP 143
Query: 155 APELYNGNYSTTQKTFK--------VKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT 205
P + T + +K +D +EC + G + + C T+G W+
Sbjct: 144 PPSIPT---FATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGN---DTITCTTHGNWTKL 197
Query: 206 PKCTKLKCSSLRLIENGYF-HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPES 264
P+C ++KC +NG+ +P K T D F CH+ Y L G + I+C G +
Sbjct: 198 PECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM 257
Query: 265 PVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECEL-NFEIHG--------SAEIR 315
P C+ C P +T GE V I+ + N +HG + E +
Sbjct: 258 PSCKA---SCKVP--------VKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKK 306
Query: 316 CEDGKWTEPPKCIEGQEKV 334
C +TE +CI+G +V
Sbjct: 307 C---SYTEDAQCIDGTIEV 322
Score = 46.6 bits (109), Expect = 7e-05
Identities = 75/341 (21%), Positives = 127/341 (37%), Gaps = 41/341 (12%)
Query: 274 CPPPP-LPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAE--IRCEDGKWTEPPKCIEG 330
CP P LP ++ + T Y GE + C+ + G I G W P ++
Sbjct: 23 CPKPDDLPFSTVVPL-KTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW--PINTLKC 79
Query: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-GKWTLPPEC 389
+V C +ENGA + Y N ++++C +G+ L+G++ C GKW+ PE
Sbjct: 80 TPRV-CPFAGILENGAVRYTTFEYPN--TISFSCNTGFYLNGADSAKCTEEGKWS--PEL 134
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGS----SVEYRCNEYYLLRGSKISRCE-QGKW 444
PP + A S S + + C + + G+ C G W
Sbjct: 135 PVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNW 194
Query: 445 SSPPVCLEPCTVNVDYMNR-NNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
+ P C E V + +R +N + + + + + D F C GY L +
Sbjct: 195 TKLPECRE---VKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLD-----GPEEI 246
Query: 504 QCNR--GEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYE-------NGSSVEYRCF 554
+C + P C K C P V V E +G V + C
Sbjct: 247 ECTKLGNWSAMPSC-----KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCK 301
Query: 555 DHHF-LEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNL 594
+ + +A C+DG P E +L+F + + +++
Sbjct: 302 NKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDV 342
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 112 bits (280), Expect = 1e-24
Identities = 151/577 (26%), Positives = 233/577 (40%), Gaps = 76/577 (13%)
Query: 25 CGFPHV-ENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSP 83
CG P +NG + YT + K + C GY ++G + T WS
Sbjct: 2531 CGLPEAPKNGMVFGKEYT---------VGTKAMYSCSEGYHLQAGAEATAECLDTGLWSN 2581
Query: 84 E---PRCFKKCTKPDLSNGYISD------VKLLYKIQENMRYGCASGYKTTGGKDEEVVQ 134
P+C T PD+S+ + + Y+ Q + C GY TG + V++
Sbjct: 2582 RNVPPQCVP-VTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTG---QRVIR 2637
Query: 135 CLSDG-WS---SQPTCR--KEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAG 188
C ++G WS S PTCR E + P NG+ T + + C +GY G
Sbjct: 2638 CQANGKWSLGDSTPTCRIISCGELPIPP---NGHRIGTLSVYGAT--AIFSCNSGYTLVG 2692
Query: 189 GKKTEEVECLTYG-WSLTP-KCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYY 246
+ E C+ G WS + +C C + I NG+ + +Y V Q C+ +
Sbjct: 2693 SRVRE---CMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQ--CNAGFR 2747
Query: 247 LSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELN 305
L G + C + W ++P C C P P +S++ S Y G +V C
Sbjct: 2748 LIGMSVRICQQDHHWSGKTPFCV--LVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGK 2803
Query: 306 FEIHGSAEIRCE-DGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYAC 364
+ G++ C DG WT G C +P +G S + G + ++C
Sbjct: 2804 RTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDS--FDPGTVMRFSC 2861
Query: 365 KSGYLLHGSNEITCN-RGKWT-LPPECVENNENCKHPPVVMNGAV--ADGILASYATGSS 420
++G++L GS+E TC G W+ PEC +C +P N V +DG++ S SS
Sbjct: 2862 EAGHVLRGSSERTCQANGSWSGSQPEC--GVISCGNPGTPSNARVVFSDGLVFS----SS 2915
Query: 421 VEYRCNEYYLLRGSKISRCE-QGKWS-SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLH 478
+ Y C E Y G C G W+ S P CL + N + + + +
Sbjct: 2916 IVYECREGYYATGLLSRHCSVNGTWTGSDPECL-VINCGDPGIPANGLRLGNDFR----Y 2970
Query: 479 GDLIDFVCKQGYDLSPLTPLSELSVQCNR-GEVKYPLCTRKESKGMCTSPPLIKHGVIIS 537
+ + C GY + +S LS +R P+C MC PPLI +G ++
Sbjct: 2971 NKTVTYQCVPGY-MMESHRVSVLSCTKDRTWNGTKPVCKAL----MCKPPPLIPNGKVVG 3025
Query: 538 STVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
S + GSSV Y C + + L C +G WT
Sbjct: 3026 S---DFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWT 3059
Score = 104 bits (260), Expect = 2e-22
Identities = 119/416 (28%), Positives = 170/416 (40%), Gaps = 43/416 (10%)
Query: 55 LSFFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRC-FKKCTKPDLSNGYISDVKLLYK-- 109
+ F C AG+ R + TC G WS +P C C P G S+ ++++
Sbjct: 2857 MRFSCEAGHVL---RGSSERTCQANGSWSGSQPECGVISCGNP----GTPSNARVVFSDG 2909
Query: 110 --IQENMRYGCASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYNGNYST 165
++ Y C GY TG C +G W+ S P C + C P + N
Sbjct: 2910 LVFSSSIVYECREGYYATGLLSRH---CSVNGTWTGSDPECLVIN--CGDPGI-PANGLR 2963
Query: 166 TQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLT-PKCTKLKCSSLRLIENGYF 224
F+ V Y+C GY + + W+ T P C L C LI NG
Sbjct: 2964 LGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKV 3023
Query: 225 HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINS 283
V + G V + C E Y LS + C G W E P C C P +P
Sbjct: 3024 --VGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVF--CGDPGVPSRG 3079
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKVACEEPPF 341
+ + +YR V C + GS C+ DG W+ P CI+ C +P
Sbjct: 3080 RREDRGFSYRSS--VSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCID-PTLTTCADPGV 3136
Query: 342 IENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG-KWT-LPPECVENNENCKHP 399
+ G N +S+ Y G V + C+ GYLL GS TC W+ PP+CV + +C+ P
Sbjct: 3137 PQFGIQN-NSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPH--HCRQP 3193
Query: 400 PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISR-CE-QGKWS-SPPVCLE 452
+ V G L + G ++ Y C E + L+G R C+ G W+ PP+CLE
Sbjct: 3194 ETPTHANV--GALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLE 3247
Score = 95.5 bits (236), Expect = 1e-19
Identities = 142/548 (25%), Positives = 213/548 (38%), Gaps = 68/548 (12%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRCFK-KCTKPD-LSNGYISDVKLLYKIQE 112
F C +GYT R E C G WS E RC C P+ + NG+I+ Y +
Sbjct: 2682 FSCNSGYTLVGSRVRE---CMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN--YSYRG 2736
Query: 113 NMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAPELYNGNYSTTQKT- 169
++ Y C +G++ G V C D WS + P C L + G+ +Q +
Sbjct: 2737 SVVYQCNAGFRLIG---MSVRICQQDHHWSGKTPFC------VLVSCGHPGSPPHSQMSG 2787
Query: 170 --FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLK---CSSLRLIENGYF 224
+ V V+Y C G T G T + P C+ C + +G
Sbjct: 2788 DSYTVGAVVRYSCI-GKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGI- 2845
Query: 225 HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPPPPLPINS 283
+ +++ G V++F C + L GS C N W P C C P P N+
Sbjct: 2846 -RLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVIS--CGNPGTPSNA 2902
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKVACEEPPF 341
++ IV+ EC + G C +G WT P+C+ + C +P
Sbjct: 2903 RVVFSDGLVFSSSIVY-ECREGYYATGLLSRHCSVNGTWTGSDPECLV----INCGDPGI 2957
Query: 342 IENGAANLHSKIYYNGDKVTYACKSGYLL--HGSNEITCNRGKWTLPPECVENNENCKHP 399
NG L + YN VTY C GY++ H + ++C + + + V CK P
Sbjct: 2958 PANGL-RLGNDFRYN-KTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPP 3015
Query: 400 PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSP-PVCLEPCTVN 457
P++ NG V + + GSSV Y C E Y L + CE G W+ P C +
Sbjct: 3016 PLIPNGKVVG---SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGD 3072
Query: 458 VDYMNRNNIEMK-WKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEV---KYP 513
+R E + + Y V F C PL + C P
Sbjct: 3073 PGVPSRGRREDRGFSYRSSV------SFSCHP-----PLVLVGSPRRFCQSDGTWSGTQP 3121
Query: 514 LCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGM-W 572
C + C P + + G I + Y+ GS+V +RC + L+GS CL + W
Sbjct: 3122 SCI-DPTLTTCADPGVPQFG--IQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTW 3178
Query: 573 T-TPPLCL 579
+ TPP C+
Sbjct: 3179 SGTPPDCV 3186
Score = 47.4 bits (111), Expect = 4e-05
Identities = 59/267 (22%), Positives = 107/267 (40%), Gaps = 44/267 (16%)
Query: 332 EKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGK---WTLP-P 387
E + CE+P + G +H + ++ G V+++C GY L GS E+ C G+ W P P
Sbjct: 1207 ELIKCEDPGTPKFGY-KVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLP 1265
Query: 388 ECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP 447
CV + G V+ +L S + E+ N + + E G
Sbjct: 1266 TCVAECGG------TVRGEVSGQVL-SPGYPAPYEHNLNCIWTI------EAEAG----- 1307
Query: 448 PVCLEPCTVNVDYMNRNNIEMK-----W--KYEGKVLHGDLIDFVCKQGYDLSPLTPLSE 500
CT+ + ++ + E+ W E VL +L + + + + +
Sbjct: 1308 ------CTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQ 1361
Query: 501 LSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLE 560
S + + + + C P + ++G S + D++E G S ++C + L+
Sbjct: 1362 FSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNG---SRSGDSWEAGDSTVFQCDPGYALQ 1418
Query: 561 GSREAYCLD----GMW-TTPPLCLEPC 582
GS E C+ W +PP C+ PC
Sbjct: 1419 GSAEISCVKIENRFFWQPSPPTCIAPC 1445
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/249 (23%), Positives = 89/249 (35%), Gaps = 64/249 (25%)
Query: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK----WS 445
V +C P + NG+ + S+ G S ++C+ Y L+GS C + + W
Sbjct: 1379 VSTATSCNDPGIPQNGSRSGD---SWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQ 1435
Query: 446 -SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLID-----------------FVCK 487
SPP C+ PC D + + + Y G D F +
Sbjct: 1436 PSPPTCIAPC--GGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLE 1493
Query: 488 QGYDL-------SPLTPL------SELSVQCNRGEVKYPLCTRKES-------------- 520
GYD L+PL S+L + L R ++
Sbjct: 1494 PGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTEN 1553
Query: 521 -KGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDG-----MWTT 574
+ C P IK+G + S + GSSV Y C + +EG+ C+ G +W
Sbjct: 1554 PRESCFDPGSIKNGTRVGSDLKL---GSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNN 1610
Query: 575 P-PLCLEPC 582
P P+C PC
Sbjct: 1611 PRPVCTAPC 1619
Score = 44.7 bits (104), Expect = 3e-04
Identities = 52/235 (22%), Positives = 86/235 (36%), Gaps = 64/235 (27%)
Query: 413 ASYATGSSVEYRCNEYYLLRGSKISRC-----EQGKWS-SPPVCLEPCTVNVDYMN---- 462
+ ++ G+ V + CN Y L+GS C +W+ S P C+ PC N+
Sbjct: 1749 SDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTIL 1808
Query: 463 --------RNNIEMKWKY---EGKVLHGDLIDFVCKQGYDL--------SPLTPL----- 498
N++ WK EG + ++ FV +Q +D + +T L
Sbjct: 1809 SPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSG 1868
Query: 499 -------------------SELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISST 539
S++SV ++Y + C P + +GV T
Sbjct: 1869 TTVPALLNSTSNQLYLHFYSDISVSAAGFHLEY----KTVGLSSCPEPAVPSNGV---KT 1921
Query: 540 VDTYENGSSVEYRCFDHHFLEGSREAYCLDG---MWT-TPPLCLEPCTLSFTEME 590
+ Y V ++C + L+G C+ G W PPLC+ C + EME
Sbjct: 1922 GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEME 1976
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/428 (20%), Positives = 157/428 (36%), Gaps = 81/428 (18%)
Query: 212 KCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPE----SPVC 267
KC ++ N + + GD+V++ C + L G++++ C G Y + P+C
Sbjct: 2293 KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTC-KLGTYLQFEGPPPIC 2351
Query: 268 EGRRNRCPPPPLPINSK----IQTHSTTYRHGE----IVHIECELN-------------- 305
E CP L +S Q++ +Y + +V +E + N
Sbjct: 2352 EVH---CPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQY 2408
Query: 306 --FEIHG-----SAEIRCEDGKWTEPPKCIEGQEKVACE----------------EPPFI 342
FEI S ++ G ++ P V P+
Sbjct: 2409 DEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC 2468
Query: 343 ENGAANLHSKIYYN-----GDKVTYACKSGYLLHGSNEITCNRGK--WTLPPECVENNE- 394
A LH I G + + C +GY L G + C R + L E + +
Sbjct: 2469 SLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQA 2528
Query: 395 -NCKHPPVVMNGAVADGILASYATGSSVEYRCNE-YYLLRGSKISR--CEQGKWSS---P 447
+C P NG V Y G+ Y C+E Y+L G++ + + G WS+ P
Sbjct: 2529 LSCGLPEAPKNGMVFG---KEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP 2585
Query: 448 PVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN- 506
P C+ +V ++ + + +E + + +C GY + + ++C
Sbjct: 2586 PQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYT-----GQRVIRCQA 2640
Query: 507 RGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAY 566
G+ T C P+ +G I T+ Y G++ + C + L GSR
Sbjct: 2641 NGKWSLGDSTPTCRIISCGELPIPPNGHRI-GTLSVY--GATAIFSCNSGYTLVGSRVRE 2697
Query: 567 CL-DGMWT 573
C+ +G+W+
Sbjct: 2698 CMANGLWS 2705
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/85 (32%), Positives = 33/85 (38%), Gaps = 8/85 (9%)
Query: 383 WTLPPECVENN-ENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ 441
W L P C + C P NG V A Y G SV + C Y L G + C+
Sbjct: 2109 WDLDPGCEAYELQECPDPEPFANGIVRG---AGYNVGQSVTFECLPGYQLTGHPVLTCQH 2165
Query: 442 G---KWSSP-PVCLEPCTVNVDYMN 462
G W P P C PC N+ N
Sbjct: 2166 GTNRNWDHPLPKCEVPCGGNITSSN 2190
Score = 39.3 bits (90), Expect = 0.012
Identities = 52/214 (24%), Positives = 76/214 (35%), Gaps = 61/214 (28%)
Query: 234 GDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCE--------GRRNRCPPPPLPI--- 281
G +V F C Y LS + ++C NF W P CE G P P
Sbjct: 886 GALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYP 945
Query: 282 NSKIQTHSTTYRHGEIVHIECELNFEIHGSAE--IRCEDGKWTEPPKCIEGQEKVA---- 335
N+ T HG+ V F + + + E+G +T+P + + G A
Sbjct: 946 NNLNCTWIIETSHGKGVFFTFH-TFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISA 1004
Query: 336 ----------------------------------CEEPPFIENGAANLHSKIYYN-GDKV 360
CEEP E A ++ + + GD +
Sbjct: 1005 GLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEP---EVPAYSIRKGLQFGVGDTL 1061
Query: 361 TYACKSGYLLHGSNEITCNRGK---WTLP-PECV 390
T++C GY L G+ ITC G+ W+ P P CV
Sbjct: 1062 TFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCV 1095
Score = 38.9 bits (89), Expect = 0.015
Identities = 57/256 (22%), Positives = 92/256 (35%), Gaps = 70/256 (27%)
Query: 394 ENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK-----WSSP- 447
E+C P + NG L GSSV Y C+ Y + G+ C G W++P
Sbjct: 1556 ESCFDPGSIKNGTRVGSDLK---LGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPR 1612
Query: 448 PVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL-------TPLSE 500
PVC PC Y+ + + + Y G + + D T L++
Sbjct: 1613 PVCTAPC--GGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALND 1670
Query: 501 LSVQCNRGEVKY----------------PLCTRKE------SKGM--------------- 523
+ V+ + G ++ PL T + +KG+
Sbjct: 1671 V-VEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPR 1729
Query: 524 -----CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-----GMW- 572
C+S P ++G + S + G+ V + C + L+GS E CL W
Sbjct: 1730 TSATQCSSVPEPRYGKRLGSD---FSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWN 1786
Query: 573 TTPPLCLEPCTLSFTE 588
+ P C+ PC + TE
Sbjct: 1787 VSAPTCVVPCGGNLTE 1802
Score = 38.5 bits (88), Expect = 0.020
Identities = 64/286 (22%), Positives = 99/286 (34%), Gaps = 49/286 (17%)
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTLPPE-CV 390
+C EP NG + Y D V++ C+ GY L G I+C G +W PP C+
Sbjct: 1908 SCPEPAVPSNGVKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965
Query: 391 ENNENCKHPPVVMNGAV-ADGILASYATGSSVEYRC--------------------NEYY 429
C M G + + G +Y + ++ ++Y
Sbjct: 1966 ---AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYI 2022
Query: 430 LLRGSKISRCE-QGKWSS---PPVCLEPCTVNVDYM----NRNNIEMKWKYEGKVLHGDL 481
+R G++S P L Y ++N K +Y+ +
Sbjct: 2023 EIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQI 2082
Query: 482 IDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV 540
F+ +G+DLS L S V + P C E + C P +G++ +
Sbjct: 2083 SSFL--RGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQ-ECPDPEPFANGIVRGA-- 2137
Query: 541 DTYENGSSVEYRCFDHHFLEGSREAYCLDGM---WTTP-PLCLEPC 582
Y G SV + C + L G C G W P P C PC
Sbjct: 2138 -GYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC 2182
Score = 37.0 bits (84), Expect = 0.058
Identities = 64/315 (20%), Positives = 109/315 (34%), Gaps = 58/315 (18%)
Query: 202 WSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF--- 258
+ P+ + +CSS+ E Y + + G +V+F C+ Y L GS I+C
Sbjct: 1724 YQAVPRTSATQCSSVP--EPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGA 1781
Query: 259 --GWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIV----------HIECELNF 306
W +P C +P + T R G I+ + C
Sbjct: 1782 LAQWNVSAPTC----------VVPCGGNL-----TERRGTILSPGFPEPYLNSLNCVWKI 1826
Query: 307 EIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKS 366
+ A I+ + + + Q + E +N L S + + +
Sbjct: 1827 VVPEGAGIQIQVVSF------VTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN 1880
Query: 367 GYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCN 426
LH ++I+ + + L + V +C P V NG Y V ++C
Sbjct: 1881 QLYLHFYSDISVSAAGFHLEYKTV-GLSSCPEPAVPSNGVKTG---ERYLVNDVVSFQCE 1936
Query: 427 EYYLLRGSKISRCEQG---KWS-SPPVCLEPCTVNVDYMN------------RNNIEMKW 470
Y L+G C G +W+ PP+C+ C V+ M +N++ W
Sbjct: 1937 PGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSW 1996
Query: 471 KYEGKVLHGDLIDFV 485
K V G I F+
Sbjct: 1997 KIALPVGFGAHIQFL 2011
Score = 36.6 bits (83), Expect = 0.076
Identities = 25/73 (34%), Positives = 30/73 (41%), Gaps = 7/73 (9%)
Query: 321 WTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
W P C E E C +P NG + Y G VT+ C GY L G +TC
Sbjct: 2109 WDLDPGC-EAYELQECPDPEPFANGI--VRGAGYNVGQSVTFECLPGYQLTGHPVLTCQH 2165
Query: 381 G---KWTLP-PEC 389
G W P P+C
Sbjct: 2166 GTNRNWDHPLPKC 2178
Score = 35.4 bits (80), Expect = 0.17
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 8/60 (13%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGK-----WTLP-PEC 389
C P + NG + GDKV Y+C G+ L G +TC+ G W P P C
Sbjct: 139 CGNPGRLPNGIQQ--GSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/42 (40%), Positives = 18/42 (42%), Gaps = 5/42 (11%)
Query: 234 GDVVQFFCHENYYLSGSDLIQCYNF-----GWYPESPVCEGR 270
G VQF C+E Y L GS I C W PVC R
Sbjct: 362 GSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAR 403
Score = 32.3 bits (72), Expect = 1.4
Identities = 20/63 (31%), Positives = 25/63 (39%), Gaps = 6/63 (9%)
Query: 209 TKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY----NFGWYPES 264
T C+ + +NG ++E GD F C Y L GS I C F W P
Sbjct: 1381 TATSCNDPGIPQNG--SRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSP 1438
Query: 265 PVC 267
P C
Sbjct: 1439 PTC 1441
Score = 32.0 bits (71), Expect = 1.9
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 546 GSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPCTLSFT 587
G ++ + CF + LEG+ CL G +W++P P C+ C S T
Sbjct: 1058 GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT 1103
Score = 31.6 bits (70), Expect = 2.4
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 6/44 (13%)
Query: 413 ASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSS-PPVC 450
+ + GSSV++ CNE Y L+GSK C + WS PVC
Sbjct: 357 SDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVC 400
Score = 31.6 bits (70), Expect = 2.4
Identities = 16/63 (25%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPP 325
E + C P +P + + + + HG+ + EC+ FE+ G I C+ + +W+ + P
Sbjct: 515 EIEQGSCGDPGIPAYGRRE--GSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKP 572
Query: 326 KCI 328
C+
Sbjct: 573 GCV 575
Score = 30.4 bits (67), Expect = 5.4
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC 378
C +P NG H +Y G VT++C SGY L + C
Sbjct: 867 CLDPGIPVNGQR--HGNDFYVGALVTFSCDSGYTLSDGEPLEC 907
Score = 30.4 bits (67), Expect = 5.4
Identities = 22/76 (28%), Positives = 27/76 (35%), Gaps = 8/76 (10%)
Query: 199 TYGWSLTPKCTKLK---CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQC 255
+Y W L P C + C NG Y G V F C Y L+G ++ C
Sbjct: 2106 SYVWDLDPGCEAYELQECPDPEPFANGIVRGAG--YNVGQSVTFECLPGYQLTGHPVLTC 2163
Query: 256 Y---NFGWYPESPVCE 268
N W P CE
Sbjct: 2164 QHGTNRNWDHPLPKCE 2179
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 110 bits (276), Expect = 3e-24
Identities = 154/568 (27%), Positives = 239/568 (42%), Gaps = 86/568 (15%)
Query: 50 SIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WSPE---PRCFKKCTKPDLSNGYISDVK 105
++D K+ + C G+ ES Q+ C +G WS + P C K P + +S+
Sbjct: 2513 TLDSKVVYECHEGFKLESS-QQATAVCQEDGLWSNKGKPPTC-KPVACPSIE-AQLSEHV 2569
Query: 106 LLYKIQENMR-YG------CASGYKTTGGKDEEVVQCLSDG-WS---SQPTCRKEHETCL 154
+ + ++ YG C+ GY G + +++C ++G W+ +P+CR L
Sbjct: 2570 IWRLVSGSLNEYGAQVLLSCSPGYYLEGWR---LLRCQANGTWNIGDERPSCRVISCGSL 2626
Query: 155 A-PELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLTP-KCTKL 211
+ P NGN T + + C TGY G E CL G WS + +C
Sbjct: 2627 SFPP--NGNKIGTLTVYGAT--AIFTCNTGYTLVGSHVRE---CLANGLWSGSETRCLAG 2679
Query: 212 KCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGR 270
C S I NG+ +Y D V + C+ + L G+ + C + W ++PVC
Sbjct: 2680 HCGSPDPIVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPI 2737
Query: 271 RNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWTEP-PKCI 328
C P P + T+ + + ++V+ C + + G + +C +G+W+ P P C
Sbjct: 2738 T--CGHPGNPAHGF--TNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTC- 2792
Query: 329 EGQEKVACEEPPFIEN----GAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKW 383
V C +P F+EN G N Y G + Y CK G+ L GS+ +TC G W
Sbjct: 2793 ---RVVNCSDPGFVENAIRHGQQNFPESFEY-GMSILYHCKKGFYLLGSSALTCMANGLW 2848
Query: 384 TLP-PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQ 441
P+C+ +C HP V N AV G L +Y G+ V Y C L G+ C E
Sbjct: 2849 DRSLPKCLA--ISCGHPGVPAN-AVLTGELFTY--GAVVHYSCRGSESLIGNDTRVCQED 2903
Query: 442 GKWS---------SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDL 492
WS +P C +P T + +R + K K L+ F C+ G+ L
Sbjct: 2904 SHWSGALPHCTGNNPGFCGDPGT--PAHGSRLGDDFKTK--------SLLRFSCEMGHQL 2953
Query: 493 SPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYR 552
+ L G P+C C +P +G+I+SS D SSV Y
Sbjct: 2954 RGSPERTCLLNGSWSG--LQPVCEAVS----CGNPGTPTNGMIVSS--DGILFSSSVIYA 3005
Query: 553 CFDHHFLEGSREAYC-LDGMWT-TPPLC 578
C++ + G +C +G WT T P C
Sbjct: 3006 CWEGYKTSGLMTRHCTANGTWTGTAPDC 3033
Score = 84.7 bits (208), Expect = 2e-16
Identities = 139/576 (24%), Positives = 213/576 (36%), Gaps = 70/576 (12%)
Query: 50 SIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRC-FKKCTKPDLSNGYISDVKLLY 108
+++ ++F C GY + G Q + SP P C C+ P I +
Sbjct: 2756 NLNDVVNFTCNTGYLLQ-GVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQ--Q 2812
Query: 109 KIQENMRYG------CASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYN 160
E+ YG C G+ G + C+++G W S P C +C P +
Sbjct: 2813 NFPESFEYGMSILYHCKKGFYLLGSS---ALTCMANGLWDRSLPKCLAI--SCGHPGV-P 2866
Query: 161 GNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLK---CSSLR 217
N T + F V Y C G + G T + ++ P CT C
Sbjct: 2867 ANAVLTGELFTYGAVVHYSCR-GSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPG 2925
Query: 218 LIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-NFGWYPESPVCEGRRNRCPP 276
+G + ++ +++F C + L GS C N W PVCE C
Sbjct: 2926 TPAHG--SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVS--CGN 2981
Query: 277 PPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE-DGKWT-EPPKCIEGQEKV 334
P P N I + +++ C ++ G C +G WT P C +
Sbjct: 2982 PGTPTNGMIVSSDGILFSSSVIYA-CWEGYKTSGLMTRHCTANGTWTGTAPDCTI----I 3036
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHG--SNEITCNR-GKWTLPPECVE 391
+C +P + NG + +N V+Y C GY++ S I C + G+W P + V
Sbjct: 3037 SCGDPGTLANGI-QFGTDFTFN-KTVSYQCNPGYVMEAVTSATIRCTKDGRWN-PSKPVC 3093
Query: 392 NNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGKWSSP-PV 449
C PP V NG V + + GSS+ Y C + Y L S I CE +G W P
Sbjct: 3094 KAVLCPQPPPVQNGTVEG---SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQ 3150
Query: 450 CLEPCTVNVDYMNRNNIEMKWKYEGKVL-HGDLIDFVCKQGYDLSPLTPLSELSVQCNRG 508
CL + I + + GK + + F CK SP + C
Sbjct: 3151 CLPV------FCGDPGIPAEGRLSGKSFTYKSEVFFQCK-----SPFILVGSSRRVCQAD 3199
Query: 509 EVK---YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREA 565
P C + C P G+ SS YE GS+V +RC + ++GS
Sbjct: 3200 GTWSGIQPTCI-DPAHNTCPDPGTPHFGIQNSSR--GYEVGSTVFFRCRKGYHIQGSTTR 3256
Query: 566 YCLDGM-WT------TPPLCLEPCTLSFTEMEKNNL 594
CL + W+ P C +P T + ++ +L
Sbjct: 3257 TCLANLTWSGIQTECIPHACRQPETPAHADVRAIDL 3292
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/364 (26%), Positives = 129/364 (35%), Gaps = 38/364 (10%)
Query: 57 FFCLAGYTTESGRQEEQTTCTTEGWSPEPRC-FKKCTKPD-LSNGYISDVKLLYKIQENM 114
+ C GY T SG T P C C P L+NG + + +
Sbjct: 3004 YACWEGYKT-SGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFN--KTV 3060
Query: 115 RYGCASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETC-LAPELYNGNYSTTQKTFK 171
Y C GY ++C DG W+ S+P C+ C P + NG + F+
Sbjct: 3061 SYQCNPGY-VMEAVTSATIRCTKDGRWNPSKPVCKAV--LCPQPPPVQNGTVEGSD--FR 3115
Query: 172 VKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLIENGYFHPVKQ 229
+ Y C GY + + + C G W P+C + C + G
Sbjct: 3116 WGSSISYSCMDGYQLS---HSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSF 3172
Query: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVC-EGRRNRCPPPPLPINSKIQT 287
TY+ V F C + L GS C G W P C + N CP P P + IQ
Sbjct: 3173 TYKSE--VFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTP-HFGIQN 3229
Query: 288 HSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTE-PPKCIEGQEKVACEEPPFIENG 345
S Y G V C + I GS C + W+ +CI AC +P +
Sbjct: 3230 SSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPH----ACRQPETPAHA 3285
Query: 346 AANLHSKIYYNGDKVTYACKSGYLLHGSNE-ITCNRG-KWT-LPPECV-----ENNENCK 397
+ G + Y C G+ L G +E TC KWT P C E NE
Sbjct: 3286 DVRAIDLPTF-GYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVT 3344
Query: 398 HPPV 401
PV
Sbjct: 3345 KTPV 3348
Score = 50.4 bits (119), Expect = 5e-06
Identities = 62/231 (26%), Positives = 96/231 (41%), Gaps = 27/231 (11%)
Query: 357 GDKVTYACKSGYLLHGSNEITCNRG-----KW-TLPPECVENNENCKHPPVVMNGAVADG 410
G KV Y CK GY + G + TC R +W +L P C +C P NG+
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLC--QAVSCGIPESPGNGSFTGN 2510
Query: 411 ILASYATGSSVEYRCNEYYLLRGSKISRC---EQGKWSS---PPVCLEPCTVNVDYMNRN 464
+ S V Y C+E + L S+ + E G WS+ PP C +++
Sbjct: 2511 ---EFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSE 2567
Query: 465 NIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL-SELSVQCNRGEVKYPLCTRKESKGM 523
++ + +G + C GY L L + + N G+ + P C R S G
Sbjct: 2568 HVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDER-PSC-RVISCGS 2625
Query: 524 CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL-DGMWT 573
+ PP +G I T+ Y G++ + C + L GS CL +G+W+
Sbjct: 2626 LSFPP---NGNKI-GTLTVY--GATAIFTCNTGYTLVGSHVRECLANGLWS 2670
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/98 (32%), Positives = 47/98 (47%), Gaps = 8/98 (8%)
Query: 369 LLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEY 428
L+H ++ + NR + L + E +NC PP NG + I + Y+ G SV + C
Sbjct: 2062 LIHFYSDHSQNRQGFKLAYQAYEL-QNCPDPPPFQNGYM---INSDYSVGQSVSFECYPG 2117
Query: 429 YLLRGSKISRCEQG---KWSSP-PVCLEPCTVNVDYMN 462
Y+L G + C+ G W+ P P C PC NV N
Sbjct: 2118 YILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQN 2155
Score = 44.7 bits (104), Expect = 3e-04
Identities = 61/268 (22%), Positives = 94/268 (35%), Gaps = 70/268 (26%)
Query: 413 ASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSSP-PVCLEPCTVNVDYMN---- 462
+ ++ GS V + CN YLL+GS C+ +W+ P C+ PC+ N
Sbjct: 1756 SEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTIL 1815
Query: 463 --------RNNIEMKWKY---EGKVLHGDLIDFVCKQGYD-----------------LSP 494
NN+ WK EG + +I F +Q +D S
Sbjct: 1816 SPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSG 1875
Query: 495 LTPLSELSVQCNR-----------GEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTY 543
T + L+ N+ + L + C P L + + I D Y
Sbjct: 1876 TTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIKIG---DRY 1932
Query: 544 ENGSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPC--TLS----------FT 587
+ ++C + L+G C+ G W P PLC+ C TLS F
Sbjct: 1933 MVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLSTLGGVILSPGFP 1992
Query: 588 EMEKNNLLLKWDFDNRPHILHGEYIEFI 615
NNL W I +G +I+F+
Sbjct: 1993 GSYPNNLDCTWRIS--LPIGYGAHIQFL 2018
Score = 42.4 bits (98), Expect = 0.001
Identities = 22/61 (36%), Positives = 32/61 (52%), Gaps = 5/61 (8%)
Query: 334 VACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC---NRGKWTLP-PEC 389
V CE+P I N + + ++ V Y+C GY +HGSN +TC +R W P P C
Sbjct: 1216 VKCEDPG-IPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSC 1274
Query: 390 V 390
+
Sbjct: 1275 I 1275
Score = 38.9 bits (89), Expect = 0.015
Identities = 89/430 (20%), Positives = 140/430 (32%), Gaps = 102/430 (23%)
Query: 232 EEGDVVQFFCHENYYLSGSDLIQCYN----FGWYPESPV----CEGRRNRCPPPPLPINS 283
E GD V F C Y L G I C F W P+ P C G N P + ++
Sbjct: 1409 EAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGG--NLTGPAGVILSP 1466
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPK-----CIEGQEKVACEE 338
+ Y G+ EC+ +++ I + P EG++
Sbjct: 1467 N---YPQPYPPGK----ECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDS---NS 1516
Query: 339 PPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKH 398
P + +I +G+ + A +S + S + K E C
Sbjct: 1517 PLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEK---------PREACFD 1567
Query: 399 PPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP------PVCLE 452
P +MNG + + GS++ Y+C+ Y + C G P P C
Sbjct: 1568 PGNIMNGT---RVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA 1624
Query: 453 PCTVNVDYMNRNNIEMKWKYEGKVLHGDLI--------DFVC--KQGYDLSPLTPLSEL- 501
PC Y + + Y G + +FV + Y + L L+EL
Sbjct: 1625 PC--GGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELF 1682
Query: 502 -----------SVQCNRGEVKYPLCTRKE--------------------------SKGMC 524
S+ + PL T + S C
Sbjct: 1683 DGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQC 1742
Query: 525 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLD-----GMWT-TPPLC 578
+S P ++G I S + GS V + C + L+GS +C W T P C
Sbjct: 1743 SSVPEPRYGRRIGSE---FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Query: 579 LEPCTLSFTE 588
+ PC+ +FT+
Sbjct: 1800 VVPCSGNFTQ 1809
Score = 37.7 bits (86), Expect = 0.034
Identities = 27/92 (29%), Positives = 39/92 (42%), Gaps = 16/92 (17%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTLP-PECVE 391
C +PP +NG + + Y G V++ C GY+L G +TC G W P P C
Sbjct: 2088 CPDPPPFQNGY--MINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRC-- 2143
Query: 392 NNENCKHPPVVMNGAVADGILASYATGSSVEY 423
+ C + NG + Y+ G EY
Sbjct: 2144 -DAPCGYNVTSQNGTI-------YSPGFPDEY 2167
Score = 37.4 bits (85), Expect = 0.044
Identities = 23/60 (38%), Positives = 29/60 (48%), Gaps = 7/60 (11%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC----NRGKWTL-PPECV 390
C +P +NG S+ GD VT+ C GY L G +ITC NR W PP C+
Sbjct: 1392 CNDPGMPQNGTRYGDSR--EAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCI 1449
Score = 37.4 bits (85), Expect = 0.044
Identities = 52/246 (21%), Positives = 82/246 (33%), Gaps = 61/246 (24%)
Query: 202 WSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-- 259
+ P+ + +CSS+ E Y + + G +V+F C+ Y L GS + C +
Sbjct: 1731 YQAVPRTSDTQCSSVP--EPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNA 1788
Query: 260 ---WYPESPVC--------EGRRNRCPPPPLP------INS--KIQTHSTTYRHGEIVHI 300
W P C RR P P +N KI + +++
Sbjct: 1789 LAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISF 1848
Query: 301 ECELNF---EIHGSAEI---RCEDGKWTEPPKCIEGQEK--------------------- 333
E N+ EIH ++ R T P +
Sbjct: 1849 ATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEY 1908
Query: 334 -----VACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRG---KWTL 385
AC+EP N Y D +++ C+ GY L G + I+C G +W
Sbjct: 1909 KTVGLAACQEPALPSNSIKI--GDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNY 1966
Query: 386 P-PECV 390
P P C+
Sbjct: 1967 PSPLCI 1972
Score = 36.6 bits (83), Expect = 0.076
Identities = 22/60 (36%), Positives = 27/60 (45%), Gaps = 8/60 (13%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-----NRGKWTLP-PEC 389
C P I G LH + GDK+ Y+C GY+L G +TC N W P P C
Sbjct: 145 CGNPGEILKGV--LHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Score = 36.2 bits (82), Expect = 0.099
Identities = 77/366 (21%), Positives = 134/366 (36%), Gaps = 57/366 (15%)
Query: 231 YEEGDVVQFFCHENYYLSGSDLIQC---YNFGWYPESPVCEGRRNRCPPPPLPINSKIQT 287
+E GD V++ CH Y L G+D++ C + P CE +CP + S
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA---QCPANEVRTGSSGVI 2333
Query: 288 HSTTYRHGEIVHIECELNFEIHGSAEIRC-----EDGKWTEPPKCIEGQEKVACEEPPFI 342
S Y C + ++ + I + K + + +G + + P +
Sbjct: 2334 LSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDG----SSGQSPLL 2389
Query: 343 ENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWT--LPPECVENNENCKHPP 400
+ N + T YL ++ T +G P C + HP
Sbjct: 2390 VVLSGN-----HTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYC-----SLTHP- 2438
Query: 401 VVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQG-----KWSS-PPVC-LEP 453
+ NG + + + A GS V Y C Y + G + C + +W S P+C
Sbjct: 2439 -LKNGGILN--RTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVS 2495
Query: 454 CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDL----SPLTPLSELSVQCNRGE 509
C + N + ++ + KV+ + C +G+ L E + N+G
Sbjct: 2496 CGIPESPGNGSFTGNEFTLDSKVV------YECHEGFKLESSQQATAVCQEDGLWSNKG- 2548
Query: 510 VKYPLCTRKESKGMCTSPPLIKHGV--IISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
K P C K L +H + ++S +++ Y G+ V C ++LEG R C
Sbjct: 2549 -KPPTC--KPVACPSIEAQLSEHVIWRLVSGSLNEY--GAQVLLSCSPGYYLEGWRLLRC 2603
Query: 568 -LDGMW 572
+G W
Sbjct: 2604 QANGTW 2609
Score = 35.0 bits (79), Expect = 0.22
Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 5/52 (9%)
Query: 336 CEEPPFIENG--AANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTL 385
C +P ENG A + S++ G V ++C+ Y+L GS ITC R TL
Sbjct: 349 CPDPGIPENGRRAGSDFSRV---GANVQFSCEDNYVLQGSKSITCQRVTETL 397
Score = 34.7 bits (78), Expect = 0.29
Identities = 16/38 (42%), Positives = 23/38 (60%), Gaps = 4/38 (10%)
Query: 357 GDKVTYACKSGYLLHGSNEITC---NRGKWTLP-PECV 390
GD +T++C GY L G+ ++TC R W+ P P CV
Sbjct: 1065 GDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/42 (38%), Positives = 18/42 (42%), Gaps = 5/42 (11%)
Query: 234 GDVVQFFCHENYYLSGSDLIQCYNF-----GWYPESPVCEGR 270
G VQF C +NY L GS I C W P+C R
Sbjct: 369 GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRAR 410
Score = 32.7 bits (73), Expect = 1.1
Identities = 57/303 (18%), Positives = 97/303 (32%), Gaps = 68/303 (22%)
Query: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKW--------TLPP 387
C+ PP + + GD V Y C GY L G++ +TC T
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318
Query: 388 ECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ------ 441
+C N V+++ S S++ N + +Q
Sbjct: 2319 QCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEV 2378
Query: 442 --GKWSSPPVCLEPCTVNVDYMN----RNNIEMKWKYE---------------------- 473
G P+ + + + N N + ++W +
Sbjct: 2379 FDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHP 2438
Query: 474 ---GKVLH------GDLIDFVCKQGYDLSPLTPLSELSVQCNR---GEVKYPLCTRKESK 521
G +L+ G + + CK GY + + + C R G ++ T
Sbjct: 2439 LKNGGILNRTAGAVGSKVHYFCKPGYRM-----VGHSNATCRRNPLGMYQWDSLTPLCQA 2493
Query: 522 GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCL---DGMWTT---P 575
C P +G S T + + S V Y C + LE S++A + DG+W+ P
Sbjct: 2494 VSCGIPESPGNG---SFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKP 2550
Query: 576 PLC 578
P C
Sbjct: 2551 PTC 2553
Score = 32.0 bits (71), Expect = 1.9
Identities = 52/250 (20%), Positives = 88/250 (35%), Gaps = 60/250 (24%)
Query: 393 NENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQ-----GKWSS- 446
++ C P + NG A + G++V++ C + Y+L+GSK C++ WS
Sbjct: 346 SDMCPDPGIPENGRRAGSDFSR--VGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDH 403
Query: 447 PPVC-LEPC------------TVNVDYMNRNNIEMKWKY----EGKVLHGDLIDFVCKQG 489
P+C C + N +N W KV+ +F ++G
Sbjct: 404 RPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG 463
Query: 490 YD----------------LSPLTPLS--------------ELSVQCNRGEVKYPLCTRKE 519
YD L LT S L + G + ++
Sbjct: 464 YDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEI 523
Query: 520 SKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYC-LDGMWT-TPPL 577
KG C P + +G T ++ +G ++ + C L G R C + W+ P
Sbjct: 524 EKGGCGDPGIPAYG---KRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPS 580
Query: 578 CLEPCTLSFT 587
C+ C +FT
Sbjct: 581 CVFSCFFNFT 590
Score = 31.6 bits (70), Expect = 2.4
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 1/44 (2%)
Query: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE 317
CP P +P N + + S R G V CE N+ + GS I C+
Sbjct: 349 CPDPGIPENGR-RAGSDFSRVGANVQFSCEDNYVLQGSKSITCQ 391
Score = 31.2 bits (69), Expect = 3.2
Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 4/63 (6%)
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPP 325
E + C P +P K +++ HG+ + EC FE+ G I C ++ +W+ P
Sbjct: 522 EIEKGGCGDPGIPAYGK--RTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKP 579
Query: 326 KCI 328
C+
Sbjct: 580 SCV 582
Score = 30.8 bits (68), Expect = 4.2
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 4/44 (9%)
Query: 546 GSSVEYRCFDHHFLEGSREAYCLDG---MWTTP-PLCLEPCTLS 585
G S+ + CF + LEG+ + CL G +W+ P P C+ C S
Sbjct: 1065 GDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGAS 1108
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 108 bits (270), Expect = 2e-23
Identities = 112/443 (25%), Positives = 168/443 (37%), Gaps = 51/443 (11%)
Query: 166 TQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLTPKCTKLKCSSLRLIENGYF 224
T+ FK ++Y C GY + T+ + C + G W C +C + NG
Sbjct: 67 TETRFKTGTTLKYTCLPGYVRS--HSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQV 124
Query: 225 HPVKQTYEEGDVVQFFCHENYYLSGSDLIQC----YNFGWYPESPVCEGRRNRCPPPPLP 280
+K G ++F C E ++L GS +C GW P CE +C PPP
Sbjct: 125 E-IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCE--IVKCKPPPDI 181
Query: 281 INSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-----EDGKW-TEPPKCIEGQEKV 334
N + Y +G V C+ F + G A I C G W PP C EK+
Sbjct: 182 RNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC----EKI 237
Query: 335 ACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR-GKWT-LPPECVEN 392
C +P + IY D + + C+ G++L GS+ I C+ KW PP C N
Sbjct: 238 TCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPN 297
Query: 393 NENCKHPPVVMNGAVADGILAS----YATGSSVEYRCNEYYLLRGSKISR--CEQG-KWS 445
+C + P + + + + Y G+ + YRC+ Y + + C++ +W+
Sbjct: 298 --SCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT 355
Query: 446 SPPVCLEPCTVNVDYMNRNNIEMKWKYEGK----VLHGDLIDFVCKQGYDLSPLTPLSEL 501
C C +N I K +GD I F C + S
Sbjct: 356 PYQGCEALCCPE-PKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE---------TSRF 405
Query: 502 SVQCNRGEVKYPLCTRKESKG-MCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLE 560
S C P R S G +C PP I HG S+ ++ + Y C + L
Sbjct: 406 SAICQGDGTWSP---RTPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYILV 461
Query: 561 GSREAYCLDGMWTTP-PLCLEPC 582
G + C W+ P P C C
Sbjct: 462 GQAKLSCSYSHWSAPAPQCKALC 484
Score = 93.2 bits (230), Expect = 7e-19
Identities = 109/446 (24%), Positives = 177/446 (39%), Gaps = 63/446 (14%)
Query: 49 MSIDKKLSFFCLAGYT---TESGRQEEQTTCTTEGWS-PEPRC-FKKCTKP-DLSNGYIS 102
+S ++ F C G+ + + R E Q GWS P P+C KC P D+ NG S
Sbjct: 130 LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV--GWSHPLPQCEIVKCKPPPDIRNGRHS 187
Query: 103 DVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDG-----WS-SQPTCRKEHETCLAP 156
+ Y ++ Y C + G + C + W S PTC K TC P
Sbjct: 188 GEENFYAYGFSVTYSCDPRFSLLGHAS---ISCTVENETIGVWRPSPPTCEKI--TCRKP 242
Query: 157 ELYNGNY-STTQKTFKVKDKVQYECATGYYTAGGKKTEEVEC-LTYGWSLTPK-CTKLKC 213
++ +G S + KD + ++C G+ G + + C W+ +P C C
Sbjct: 243 DVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG---SSVIHCDADSKWNPSPPACEPNSC 299
Query: 214 SSLRLIENG----YFHPVKQ-TYEEGDVVQFFCHENYYLSGSD---LIQCYNFGWYPESP 265
+L I + Y P K+ Y G V+++ CH Y + + +I N W P
Sbjct: 300 INLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPY-- 357
Query: 266 VCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIEC-ELNFEIHGSAEIR--CE-DGKW 321
+G C P P N +I H + V+ E++F H ++ C+ DG W
Sbjct: 358 --QGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTW 415
Query: 322 T-EPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNR 380
+ P C + C PP I +G S + +++ Y C GY+L G +++C+
Sbjct: 416 SPRTPSCGD-----ICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSY 470
Query: 381 GKWTLP-PECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC 439
W+ P P+C C+ P +V D Y +V +C+ Y + G + C
Sbjct: 471 SHWSAPAPQC---KALCRKPELVNGRLSVD--KDQYVEPENVTIQCDSGYGVVGPQSITC 525
Query: 440 EQGK----------WSSPPVCLEPCT 455
+ W +P C + T
Sbjct: 526 SGNRTWYPEVPKCEWETPEGCEQVLT 551
Score = 83.6 bits (205), Expect = 5e-16
Identities = 92/350 (26%), Positives = 138/350 (39%), Gaps = 71/350 (20%)
Query: 336 CEEPPFIENGAA---NLHSKIYYNGDKVTYACKSGYLL-HGSNEITCNR-GKWTLPPECV 390
C PP + A L + G + Y C GY+ H + +TCN G+W C+
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCI 109
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK----WSS 446
+ C+HP + NG V I + GS +E+ C+E + L GS SRCE WS
Sbjct: 110 Y--KRCRHPGELRNGQVE--IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH 165
Query: 447 P-PVC-LEPCTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
P P C + C D N R++ E E +G + + C + L L S+
Sbjct: 166 PLPQCEIVKCKPPPDIRNGRHSGE-----ENFYAYGFSVTYSCDPRFSL-----LGHASI 215
Query: 504 QCNRGEVKY-------PLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDH 556
C P C K C P + HG ++S Y ++ ++C
Sbjct: 216 SCTVENETIGVWRPSPPTC----EKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKG 270
Query: 557 HFLEGSREAYC-LDGMWT-TPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEF 614
L GS +C D W +PP C E N+ + N P I H +
Sbjct: 271 FVLRGSSVIHCDADSKWNPSPPAC-----------EPNSCI------NLPDIPHASW--- 310
Query: 615 ICRGDTYPA----ELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR 660
+TYP ++Y+ G++LR +C G Y +T+ Q+ LR
Sbjct: 311 ----ETYPRPTKEDVYVVGTVLRYRCHPG---YKPTTDEPTTVICQKNLR 353
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/103 (32%), Positives = 47/103 (45%), Gaps = 10/103 (9%)
Query: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWS-P 83
C FP +IA +Y S Y +++ + C GY + + +C+ WS P
Sbjct: 426 CNFPP----KIAHGHYKQSSSY--SFFKEEIIYECDKGYILVG---QAKLSCSYSHWSAP 476
Query: 84 EPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTG 126
P+C C KP+L NG +S K Y EN+ C SGY G
Sbjct: 477 APQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVG 519
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 108 bits (269), Expect = 2e-23
Identities = 115/454 (25%), Positives = 183/454 (40%), Gaps = 59/454 (12%)
Query: 157 ELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGW-SLTP--KCTKLKC 213
E+ G++S +T+ + Y+C GY + G + C W +L P KC K C
Sbjct: 31 EILTGSWS--DQTYPEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPC 85
Query: 214 SSLRLIENGYFHPVK-QTYEEGDVVQFFCHENYYLSGS-DLIQCYNFGWYPESPVCEGRR 271
G F +E G + C+E Y L G + +C GW + P+CE +
Sbjct: 86 GHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK 145
Query: 272 NRCPPPPLPINSKIQTHSTT----YRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPP 325
C P P N KI + + Y G+ V C ++I G E+ C +DG W+ E P
Sbjct: 146 --CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKP 203
Query: 326 KCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTL 385
KC+E ++C+ P I NG+ IY ++ Y C GY + C W
Sbjct: 204 KCVE----ISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRP 258
Query: 386 PPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRC-NEYYLLRGSKISRCEQGKW 444
P C E ++C + P + NG + + + TG + Y+C N +Y ++C W
Sbjct: 259 LPSCEE--KSCDN-PYIPNGDYSP-LRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGW 314
Query: 445 SSPPVC-LEPCTV-NVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSEL- 501
P C L+PC ++ + + M+ Y V G + C + ++ TP
Sbjct: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPY-FPVAVGKYYSYYCDEHFE----TPSGSYW 369
Query: 502 -SVQCNR-GEVKYPLCTRKESKGMCTSPPL-----IKHGVIISSTVDTYENGSSVEYRCF 554
+ C + G C RK C P L HG + G S++ C
Sbjct: 370 DHIHCTQDGWSPAVPCLRK-----CYFPYLENGYNQNHG-------RKFVQGKSIDVACH 417
Query: 555 DHHFL-EGSREAYCLDGMWTTPPLCLEPCTLSFT 587
+ L + C++ W+ P C+ +SFT
Sbjct: 418 PGYALPKAQTTVTCMENGWSPTPRCIR---VSFT 448
Score = 107 bits (267), Expect = 4e-23
Identities = 100/421 (23%), Positives = 171/421 (40%), Gaps = 68/421 (16%)
Query: 4 KNLTFIIILIISGELYA-------EEKPCGFPH--------VENGRIAQYYYTFKSFYFP 48
++L +I++ GE A +++PCG P + G + +Y
Sbjct: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY---------- 106
Query: 49 MSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE-PRC-FKKC---TKPDLSNGYISD 103
K + C GY + C T+GW+ + P C KC T P+ NG I
Sbjct: 107 ---GVKAVYTCNEGYQLLG--EINYRECDTDGWTNDIPICEVVKCLPVTAPE--NGKIVS 159
Query: 104 VKLL----YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELY 159
+ Y + +R+ C SGYK G +E + C DG+ S+ + +C +P++
Sbjct: 160 SAMEPDREYHFGQAVRFVCNSGYKIEG---DEEMHCSDDGFWSKEKPKCVEISCKSPDVI 216
Query: 160 NGNYSTTQKTFKVKDKVQYECATGY-YTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRL 218
NG+ + + +K ++ QY+C GY Y+ G + C GW P C + C +
Sbjct: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERG----DAVCTESGWRPLPSCEEKSCDN-PY 271
Query: 219 IENGYFHPVKQTYEEGDVVQFFCHENYY-LSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
I NG + P++ + GD + + C +Y + + +C + GW P +P C C P
Sbjct: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDYP 328
Query: 278 PLP----INSKIQTHSTTYRHGEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEG 330
+ + ++ G+ C+ +FE + I C W+ C+
Sbjct: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLR- 387
Query: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLL-HGSNEITCNRGKWTLPPEC 389
C P++ENG H + + G + AC GY L +TC W+ P C
Sbjct: 388 ----KCYF-PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
Query: 390 V 390
+
Sbjct: 443 I 443
Score = 80.1 bits (196), Expect = 6e-15
Identities = 55/201 (27%), Positives = 86/201 (42%), Gaps = 28/201 (13%)
Query: 21 EEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKK----LSFFCLAGYTTESGRQEEQTTC 76
EEK C P++ NG Y P+ I + +++ C G+ + + C
Sbjct: 263 EEKSCDNPYIPNGD-----------YSPLRIKHRTGDEITYQCRNGFYPAT--RGNTAKC 309
Query: 77 TTEGWSPEPRC-FKKCTKPDLSNG--YISDVKLLY---KIQENMRYGCASGYKTTGGKDE 130
T+ GW P PRC K C PD+ +G Y +++ Y + + Y C ++T G
Sbjct: 310 TSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYW 369
Query: 131 EVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGK 190
+ + C DGWS C ++ C P L NG + F + C GY +
Sbjct: 370 DHIHCTQDGWSPAVPCLRK---CYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQ 426
Query: 191 KTEEVECLTYGWSLTPKCTKL 211
T V C+ GWS TP+C ++
Sbjct: 427 TT--VTCMENGWSPTPRCIRV 445
Score = 60.5 bits (145), Expect = 5e-09
Identities = 71/304 (23%), Positives = 108/304 (35%), Gaps = 36/304 (11%)
Query: 354 YYNGDKVTYACKSGYLLHGSNEITCNRGKWT-LPPECVENNENCKHPPVVMNGA--VADG 410
Y G + Y C+ GY G+ + C +G+W L P C HP G + G
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Query: 411 ILASYATGSSVEYRCNEYYLLRGS-KISRCEQGKWSSP-PVC-LEPCTVNVDYMNRNNIE 467
+ Y G Y CNE Y L G C+ W++ P+C + C N +
Sbjct: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
Query: 468 MKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG---EVKYPLCTRKESKGMC 524
+ + + G + FVC GY + + + C+ + P C C
Sbjct: 160 SAMEPDREYHFGQAVRFVCNSGYKIE-----GDEEMHCSDDGFWSKEKPKCVEIS----C 210
Query: 525 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL 584
SP +I I + Y+ +Y+C + +A C + W P C E
Sbjct: 211 KSPDVINGSPISQKII--YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC- 267
Query: 585 SFTEMEKNNLLLKWDFDNRPHILH--GEYIEFICRGDTYPAELYITGSILRMQCDRGQLK 642
N + D+ + I H G+ I + CR YPA T G +
Sbjct: 268 ------DNPYIPNGDY-SPLRIKHRTGDEITYQCRNGFYPATRGNTAKC----TSTGWIP 316
Query: 643 YPRC 646
PRC
Sbjct: 317 APRC 320
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 97.8 bits (242), Expect = 3e-20
Identities = 105/381 (27%), Positives = 156/381 (40%), Gaps = 63/381 (16%)
Query: 50 SIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRC-FKKC---TKPDLSNGYISD 103
S + S C GY S E C + G WS P P C +C T P +NG++
Sbjct: 201 SYNSSCSISCDRGYLPSS---METMQCMSSGEWSAPIPACNVVECDAVTNP--ANGFVEC 255
Query: 104 VKLLYKIQENMR--YGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAP-EL 158
+ N + C G++ G + +QC S G W ++ PTC+ TC A +
Sbjct: 256 FQNPGSFPWNTTCTFDCEEGFELMGAQS---LQCTSSGNWDNEKPTCKAV--TCRAVRQP 310
Query: 159 YNGNYSTTQKT---FKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKC 213
NG+ + F K + C G+ G +VEC T G W+ P C +C
Sbjct: 311 QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQG---PAQVECTTQGQWTQQIPVCEAFQC 367
Query: 214 SSLRLIENGYFHPVKQ---TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEG 269
++L E GY + + ++ G +F C + + L GS +QC G W E P CE
Sbjct: 368 TALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEA 427
Query: 270 RR-NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PK 326
R + PP + + + + CE FE+HGS ++ C G+WTE P
Sbjct: 428 VRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPS 487
Query: 327 C---------IEGQEKVACE-EPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEI 376
C + G+ ++C EP F G +AC G+ L+GS
Sbjct: 488 CQVVKCSSLAVPGKINMSCSGEPVF---------------GTVCKFACPEGWTLNGSAAR 532
Query: 377 TCN-RGKWT-LPPECVENNEN 395
TC G W+ L P C E+
Sbjct: 533 TCGATGHWSGLLPTCEAPTES 553
Score = 70.1 bits (170), Expect = 6e-12
Identities = 85/401 (21%), Positives = 146/401 (36%), Gaps = 46/401 (11%)
Query: 119 ASGYKTTGGKDEEVVQCLSDG------WSSQPTCRKEHETCLAPELYNGNYSTTQKTFKV 172
A G KDE+ V+ W+ + +K+ C N + S + +
Sbjct: 98 APGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVET 157
Query: 173 KDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYF---HPVKQ 229
+ +C G+ G K E++ + C++L E+G HP+
Sbjct: 158 INNYTCKCDPGF---SGLKCEQI---------------VNCTALESPEHGSLVCSHPLGN 199
Query: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINSKIQTH 288
+ C Y S + +QC + G W P C C P N ++
Sbjct: 200 -FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVE--CDAVTNPANGFVECF 256
Query: 289 ST--TYRHGEIVHIECELNFEIHGSAEIRC-EDGKW-TEPPKCIEGQEKVACEEPPFIEN 344
++ +CE FE+ G+ ++C G W E P C + V C +N
Sbjct: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC----KAVTCRAVRQPQN 312
Query: 345 GAANL-HSKI--YYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHP 399
G+ HS + + C+ G++L G ++ C +G+WT P C
Sbjct: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372
Query: 400 PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKW-SSPPVCLEPCTVN 457
P S+ GSS E+ C + ++L+GSK +C G+W + P C
Sbjct: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
Query: 458 VDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL 498
V + + G+ + F C++G++L T L
Sbjct: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQL 473
Score = 44.7 bits (104), Expect = 3e-04
Identities = 63/291 (21%), Positives = 108/291 (37%), Gaps = 32/291 (10%)
Query: 287 THSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGA 346
T+++ HGE V E + +C+ G KC + A E P
Sbjct: 144 TNTSCSGHGECV--------ETINNYTCKCDPG--FSGLKCEQIVNCTALESPEHGSLVC 193
Query: 347 ANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PECVENNENCKHPPVVMN 404
++ YN + +C GYL + C + G+W+ P P C N C N
Sbjct: 194 SHPLGNFSYNSS-CSISCDRGYLPSSMETMQCMSSGEWSAPIPAC--NVVECDAVTNPAN 250
Query: 405 GAV-ADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP-PVCLEPCTVNVDYM 461
G V S+ ++ + C E + L G++ +C G W + P C V
Sbjct: 251 GFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQP 310
Query: 462 NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN---RGEVKYPLCTRK 518
++ G+ +F C++G+ L V+C + + P+C
Sbjct: 311 QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ-----GPAQVECTTQGQWTQQIPVCEAF 365
Query: 519 ESKGMCTSPPLIKHGVI--ISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
+ CT+ + G + + S ++ GSS E+ C L+GS+ C
Sbjct: 366 Q----CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC 412
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/250 (28%), Positives = 107/250 (42%), Gaps = 26/250 (10%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPK--CTKLKCSSLRLIENGYFHPV 227
+++ ++V Y+C GY+ T + + W C + C +R NG P
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 228 KQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINS 283
TYE G + F C+E YYL G +++ C G W + P+CE + C PPP N
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE--KVLCTPPPKIKNG 171
Query: 284 K-IQTHSTTYRHGEIVHIECEL-----NFEIHGSAEIRCEDGK-WTE-PPKCIEGQEKVA 335
K + + + + V C+ F + G + I C D W+ P+C KV
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC-----KVV 226
Query: 336 CEEPPFIENG--AANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PECVE 391
P +ENG + K YY V + C G+ L GS+ I C + W P P+C++
Sbjct: 227 KCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 392 NNENCKHPPV 401
PPV
Sbjct: 286 GPRPTYKPPV 295
Score = 72.8 bits (177), Expect = 1e-12
Identities = 70/244 (28%), Positives = 103/244 (42%), Gaps = 28/244 (11%)
Query: 228 KQTYEEGDVVQFFCHENYYLS---GSDLIQCYNFGWYPESP-VCEGRRNRCPPPPLPINS 283
K YE G+ V + C + Y+ + I N W P S C R CP P+N
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACY--RETCPYIRDPLNG 108
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWT-EPPKCIEGQEKVACEE 338
+ + TY G +H C + + G + CE W+ +PP C EKV C
Sbjct: 109 QAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC----EKVLCTP 164
Query: 339 PPFIENGAANLHS-KIYYNGDKVTYACKSG-----YLLHGSNEITC-NRGKWT-LPPECV 390
PP I+NG +++ D VTY+C + L G + I C + W+ PEC
Sbjct: 165 PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC- 223
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV- 449
C+ P VV NG G + ++V + C++ + L GS C+ PPV
Sbjct: 224 -KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 450 -CLE 452
CL+
Sbjct: 282 KCLK 285
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/259 (26%), Positives = 106/259 (40%), Gaps = 20/259 (7%)
Query: 335 ACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHG--SNEITCNRGKWTLP-PECV 390
ACEEPP E K YY G++V Y CK GY + C+R LP +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGK---WSS 446
E C + +NG +Y G + + CNE Y L G +I CE +G WS
Sbjct: 94 CYRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSG 152
Query: 447 -PPVCLEP-CTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
PP+C + CT N ++ +E + D + + C P + + E ++
Sbjct: 153 KPPICEKVLCTPPPKIKNGKHTFSEVEVFE----YLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 504 QCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSR 563
C V E K + P++++G IS + ++V + C +L+GS
Sbjct: 209 YCGDNSVWSRAAP--ECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 564 EAYC-LDGMWTTP-PLCLE 580
C + W P P CL+
Sbjct: 267 TIVCDSNSTWDPPVPKCLK 285
Score = 57.4 bits (137), Expect = 4e-08
Identities = 61/245 (24%), Positives = 94/245 (38%), Gaps = 20/245 (8%)
Query: 101 ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELY 159
I K Y+I E + Y C GY + + W ETC +
Sbjct: 47 IGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPL 106
Query: 160 NGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG----WS-LTPKCTKLKCS 214
NG T++ ++ + C GYY G E + C G WS P C K+ C+
Sbjct: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCT 163
Query: 215 SLRLIENG-YFHPVKQTYEEGDVVQFFCH-----ENYYLSGSDLIQC-YNFGWYPESPVC 267
I+NG + + +E D V + C + + L G I C N W +P C
Sbjct: 164 PPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC 223
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP--P 325
+ +C P + +I + + V EC+ F + GS I C+ +P P
Sbjct: 224 --KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 326 KCIEG 330
KC++G
Sbjct: 282 KCLKG 286
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/199 (26%), Positives = 82/199 (41%), Gaps = 31/199 (15%)
Query: 393 NENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGK-WS--SP 447
++ C+ PP + Y G V+Y+C + +Y+ + + C++ W S
Sbjct: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
Query: 448 PVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
C E C D +N + YE G + F+C +GY L + E + C
Sbjct: 92 DACYRETCPYIRDPLNGQAVPANGTYE----FGYQMHFICNEGYYL-----IGEEILYCE 142
Query: 507 -RGEV-----KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF-----D 555
+G V K P+C K +CT PP IK+G S V+ +E +V Y C D
Sbjct: 143 LKGSVAIWSGKPPIC----EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD 198
Query: 556 HHFLEGSREAYCLD-GMWT 573
L G YC D +W+
Sbjct: 199 PFSLIGESTIYCGDNSVWS 217
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/173 (28%), Positives = 73/173 (42%), Gaps = 25/173 (14%)
Query: 54 KLSFFCLAGYTTESGRQEEQTTCTTEG----WSPEPRCFKK--CTKPD-LSNGY--ISDV 104
++ F C GY EE C +G WS +P +K CT P + NG S+V
Sbjct: 122 QMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEV 178
Query: 105 KLLYKIQENMRYGC--ASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYN 160
++ ++ + + Y C A G E + C + WS + P C+ C P + N
Sbjct: 179 EV-FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK--CRFPVVEN 235
Query: 161 GNY-STTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTK 210
G S K F K V +EC G+Y G ++ + C + W PKC K
Sbjct: 236 GKQISGFGKKFYYKATVMFECDKGFYLDG---SDTIVCDSNSTWDPPVPKCLK 285
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/250 (28%), Positives = 107/250 (42%), Gaps = 26/250 (10%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPK--CTKLKCSSLRLIENGYFHPV 227
+++ ++V Y+C GY+ T + + W C + C +R NG P
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 228 KQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINS 283
TYE G + F C+E YYL G +++ C G W + P+CE + C PPP N
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE--KVLCTPPPKIKNG 171
Query: 284 K-IQTHSTTYRHGEIVHIECEL-----NFEIHGSAEIRCEDGK-WTE-PPKCIEGQEKVA 335
K + + + + V C+ F + G + I C D W+ P+C KV
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC-----KVV 226
Query: 336 CEEPPFIENG--AANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PECVE 391
P +ENG + K YY V + C G+ L GS+ I C + W P P+C++
Sbjct: 227 KCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 392 NNENCKHPPV 401
PPV
Sbjct: 286 GPRPTYKPPV 295
Score = 72.8 bits (177), Expect = 1e-12
Identities = 70/244 (28%), Positives = 103/244 (42%), Gaps = 28/244 (11%)
Query: 228 KQTYEEGDVVQFFCHENYYLS---GSDLIQCYNFGWYPESP-VCEGRRNRCPPPPLPINS 283
K YE G+ V + C + Y+ + I N W P S C R CP P+N
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACY--RETCPYIRDPLNG 108
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWT-EPPKCIEGQEKVACEE 338
+ + TY G +H C + + G + CE W+ +PP C EKV C
Sbjct: 109 QAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC----EKVLCTP 164
Query: 339 PPFIENGAANLHS-KIYYNGDKVTYACKSG-----YLLHGSNEITC-NRGKWT-LPPECV 390
PP I+NG +++ D VTY+C + L G + I C + W+ PEC
Sbjct: 165 PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC- 223
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV- 449
C+ P VV NG G + ++V + C++ + L GS C+ PPV
Sbjct: 224 -KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 450 -CLE 452
CL+
Sbjct: 282 KCLK 285
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/259 (26%), Positives = 106/259 (40%), Gaps = 20/259 (7%)
Query: 335 ACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHG--SNEITCNRGKWTLP-PECV 390
ACEEPP E K YY G++V Y CK GY + C+R LP +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGK---WSS 446
E C + +NG +Y G + + CNE Y L G +I CE +G WS
Sbjct: 94 CYRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSG 152
Query: 447 -PPVCLEP-CTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
PP+C + CT N ++ +E + D + + C P + + E ++
Sbjct: 153 KPPICEKVLCTPPPKIKNGKHTFSEVEVFE----YLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 504 QCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSR 563
C V E K + P++++G IS + ++V + C +L+GS
Sbjct: 209 YCGDNSVWSRAAP--ECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 564 EAYC-LDGMWTTP-PLCLE 580
C + W P P CL+
Sbjct: 267 TIVCDSNSTWDPPVPKCLK 285
Score = 57.4 bits (137), Expect = 4e-08
Identities = 61/245 (24%), Positives = 94/245 (38%), Gaps = 20/245 (8%)
Query: 101 ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELY 159
I K Y+I E + Y C GY + + W ETC +
Sbjct: 47 IGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPL 106
Query: 160 NGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG----WS-LTPKCTKLKCS 214
NG T++ ++ + C GYY G E + C G WS P C K+ C+
Sbjct: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCT 163
Query: 215 SLRLIENG-YFHPVKQTYEEGDVVQFFCH-----ENYYLSGSDLIQC-YNFGWYPESPVC 267
I+NG + + +E D V + C + + L G I C N W +P C
Sbjct: 164 PPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC 223
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP--P 325
+ +C P + +I + + V EC+ F + GS I C+ +P P
Sbjct: 224 --KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 326 KCIEG 330
KC++G
Sbjct: 282 KCLKG 286
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/199 (26%), Positives = 82/199 (41%), Gaps = 31/199 (15%)
Query: 393 NENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGK-WS--SP 447
++ C+ PP + Y G V+Y+C + +Y+ + + C++ W S
Sbjct: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
Query: 448 PVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
C E C D +N + YE G + F+C +GY L + E + C
Sbjct: 92 DACYRETCPYIRDPLNGQAVPANGTYE----FGYQMHFICNEGYYL-----IGEEILYCE 142
Query: 507 -RGEV-----KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF-----D 555
+G V K P+C K +CT PP IK+G S V+ +E +V Y C D
Sbjct: 143 LKGSVAIWSGKPPIC----EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD 198
Query: 556 HHFLEGSREAYCLD-GMWT 573
L G YC D +W+
Sbjct: 199 PFSLIGESTIYCGDNSVWS 217
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/173 (28%), Positives = 73/173 (42%), Gaps = 25/173 (14%)
Query: 54 KLSFFCLAGYTTESGRQEEQTTCTTEG----WSPEPRCFKK--CTKPD-LSNGY--ISDV 104
++ F C GY EE C +G WS +P +K CT P + NG S+V
Sbjct: 122 QMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEV 178
Query: 105 KLLYKIQENMRYGC--ASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYN 160
++ ++ + + Y C A G E + C + WS + P C+ C P + N
Sbjct: 179 EV-FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK--CRFPVVEN 235
Query: 161 GNY-STTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTK 210
G S K F K V +EC G+Y G ++ + C + W PKC K
Sbjct: 236 GKQISGFGKKFYYKATVMFECDKGFYLDG---SDTIVCDSNSTWDPPVPKCLK 285
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/250 (28%), Positives = 107/250 (42%), Gaps = 26/250 (10%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPK--CTKLKCSSLRLIENGYFHPV 227
+++ ++V Y+C GY+ T + + W C + C +R NG P
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 228 KQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINS 283
TYE G + F C+E YYL G +++ C G W + P+CE + C PPP N
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE--KVLCTPPPKIKNG 171
Query: 284 K-IQTHSTTYRHGEIVHIECEL-----NFEIHGSAEIRCEDGK-WTE-PPKCIEGQEKVA 335
K + + + + V C+ F + G + I C D W+ P+C KV
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC-----KVV 226
Query: 336 CEEPPFIENG--AANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PECVE 391
P +ENG + K YY V + C G+ L GS+ I C + W P P+C++
Sbjct: 227 KCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 392 NNENCKHPPV 401
PPV
Sbjct: 286 GPRPTYKPPV 295
Score = 72.8 bits (177), Expect = 1e-12
Identities = 70/244 (28%), Positives = 103/244 (42%), Gaps = 28/244 (11%)
Query: 228 KQTYEEGDVVQFFCHENYYLS---GSDLIQCYNFGWYPESP-VCEGRRNRCPPPPLPINS 283
K YE G+ V + C + Y+ + I N W P S C R CP P+N
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACY--RETCPYIRDPLNG 108
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWT-EPPKCIEGQEKVACEE 338
+ + TY G +H C + + G + CE W+ +PP C EKV C
Sbjct: 109 QAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC----EKVLCTP 164
Query: 339 PPFIENGAANLHS-KIYYNGDKVTYACKSG-----YLLHGSNEITC-NRGKWT-LPPECV 390
PP I+NG +++ D VTY+C + L G + I C + W+ PEC
Sbjct: 165 PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC- 223
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV- 449
C+ P VV NG G + ++V + C++ + L GS C+ PPV
Sbjct: 224 -KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 450 -CLE 452
CL+
Sbjct: 282 KCLK 285
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/259 (26%), Positives = 106/259 (40%), Gaps = 20/259 (7%)
Query: 335 ACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHG--SNEITCNRGKWTLP-PECV 390
ACEEPP E K YY G++V Y CK GY + C+R LP +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGK---WSS 446
E C + +NG +Y G + + CNE Y L G +I CE +G WS
Sbjct: 94 CYRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSG 152
Query: 447 -PPVCLEP-CTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
PP+C + CT N ++ +E + D + + C P + + E ++
Sbjct: 153 KPPICEKVLCTPPPKIKNGKHTFSEVEVFE----YLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 504 QCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSR 563
C V E K + P++++G IS + ++V + C +L+GS
Sbjct: 209 YCGDNSVWSRAAP--ECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 564 EAYC-LDGMWTTP-PLCLE 580
C + W P P CL+
Sbjct: 267 TIVCDSNSTWDPPVPKCLK 285
Score = 57.4 bits (137), Expect = 4e-08
Identities = 61/245 (24%), Positives = 94/245 (38%), Gaps = 20/245 (8%)
Query: 101 ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELY 159
I K Y+I E + Y C GY + + W ETC +
Sbjct: 47 IGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPL 106
Query: 160 NGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG----WS-LTPKCTKLKCS 214
NG T++ ++ + C GYY G E + C G WS P C K+ C+
Sbjct: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCT 163
Query: 215 SLRLIENG-YFHPVKQTYEEGDVVQFFCH-----ENYYLSGSDLIQC-YNFGWYPESPVC 267
I+NG + + +E D V + C + + L G I C N W +P C
Sbjct: 164 PPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC 223
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP--P 325
+ +C P + +I + + V EC+ F + GS I C+ +P P
Sbjct: 224 --KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 326 KCIEG 330
KC++G
Sbjct: 282 KCLKG 286
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/199 (26%), Positives = 82/199 (41%), Gaps = 31/199 (15%)
Query: 393 NENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGK-WS--SP 447
++ C+ PP + Y G V+Y+C + +Y+ + + C++ W S
Sbjct: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
Query: 448 PVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
C E C D +N + YE G + F+C +GY L + E + C
Sbjct: 92 DACYRETCPYIRDPLNGQAVPANGTYE----FGYQMHFICNEGYYL-----IGEEILYCE 142
Query: 507 -RGEV-----KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF-----D 555
+G V K P+C K +CT PP IK+G S V+ +E +V Y C D
Sbjct: 143 LKGSVAIWSGKPPIC----EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD 198
Query: 556 HHFLEGSREAYCLD-GMWT 573
L G YC D +W+
Sbjct: 199 PFSLIGESTIYCGDNSVWS 217
Score = 35.0 bits (79), Expect = 0.22
Identities = 49/173 (28%), Positives = 73/173 (42%), Gaps = 25/173 (14%)
Query: 54 KLSFFCLAGYTTESGRQEEQTTCTTEG----WSPEPRCFKK--CTKPD-LSNGY--ISDV 104
++ F C GY EE C +G WS +P +K CT P + NG S+V
Sbjct: 122 QMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEV 178
Query: 105 KLLYKIQENMRYGC--ASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYN 160
++ ++ + + Y C A G E + C + WS + P C+ C P + N
Sbjct: 179 EV-FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK--CRFPVVEN 235
Query: 161 GNY-STTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTK 210
G S K F K V +EC G+Y G ++ + C + W PKC K
Sbjct: 236 GKQISGFGKKFYYKATVMFECDKGFYLDG---SDTIVCDSNSTWDPPVPKCLK 285
>gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
Length = 490
Score = 85.5 bits (210), Expect = 1e-16
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 30/250 (12%)
Query: 213 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-----NFGWYP-ESPV 266
C+ + ENG+ P + EG V +F C + + L G+ C GW P ++ +
Sbjct: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
Query: 267 CEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEI-----HGSAEIRCEDGKW 321
C R +P + H+ TYRHGE + I C F+I H + +DG W
Sbjct: 117 CVQEDCR-----IPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
Query: 322 TEPPKCIEGQEKVACEEPPFIENGAANLH--SKIYYNGDKVTYACKSGYLLHGSNEITCN 379
P C C P NG N+ + G ++Y C G+ L GS + C
Sbjct: 172 NNLPIC------QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
Query: 380 RGK-W-TLPPECVENNENCKHPPVVMNG--AVADGILASYATGSSVEYRCNEYYLLRGS- 434
+ W + PP C+ E C PP+V +G Y G+ VE+ C+ Y L
Sbjct: 226 QNLIWSSSPPRCLA-LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
Query: 435 KISRCEQGKW 444
K C+ G+W
Sbjct: 285 KYITCQYGEW 294
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/286 (23%), Positives = 105/286 (36%), Gaps = 68/286 (23%)
Query: 396 CKHPPVVMNG--AVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQG-----KW--SS 446
C P + NG + G+ + GS + C + + L+G+ C + W S
Sbjct: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
Query: 447 PPVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGY-----DLSPLTPLSE 500
+C+ E C + IE + HG+ + C +G+ DL + L
Sbjct: 114 NSICVQEDCRIP-------QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
Query: 501 LSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVI-ISSTVDTYENGSSVEYRCFDHHFL 559
N P+C C P +G + IS ++ G+ + YRCF L
Sbjct: 167 DDGTWNN----LPICQG------CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKL 216
Query: 560 EGSREAYCLDGM-WTTPP---LCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFI 615
+GS CL + W++ P L LE C L P + HG +F+
Sbjct: 217 DGSAYLECLQNLIWSSSPPRCLALEVCPLP------------------PMVSHG---DFV 255
Query: 616 CRGDTYPAELYITGSILRMQCDRG-----QLKYPRCIPRQSTLSYQ 656
C P E Y G+++ CD G KY C + SYQ
Sbjct: 256 CH--PRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQ 299
Score = 38.9 bits (89), Expect = 0.015
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 21/191 (10%)
Query: 3 LKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAG 62
LK+ + I S ++ C P +E+ I Y +KL C G
Sbjct: 100 LKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRH---------GEKLIITCHEG 150
Query: 63 YTTESGRQEEQTT-CTTEG-WSPEPRCFKKCTKP-DLSNGY--ISDVKLLYKIQENMRYG 117
+ + C +G W+ P C + C +P SNGY IS+++ + + + Y
Sbjct: 151 FKIRYPDLHNMVSLCRDDGTWNNLPIC-QGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
Query: 118 CASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELYNGNYSTTQK---TFKVK 173
C G+K G E +Q L WSS P E C L P + +G++ + +
Sbjct: 210 CFPGFKLDGSAYLECLQNLI--WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHG 267
Query: 174 DKVQYECATGY 184
V++ C GY
Sbjct: 268 TVVEFYCDPGY 278
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 84.3 bits (207), Expect = 3e-16
Identities = 75/267 (28%), Positives = 113/267 (42%), Gaps = 30/267 (11%)
Query: 170 FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPK--CTKLKCSSLRLIENGYFHPV 227
+++ ++V Y+C GY+ T + + W C + C +R NG P
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 228 KQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG----WYPESPVCEGRRNRCPPPPLPINS 283
TYE G + F C+E YYL G +++ C G W + P+CE + C PPP N
Sbjct: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE--KVLCTPPPKIKNG 171
Query: 284 K-IQTHSTTYRHGEIVHIECEL-----NFEIHGSAEIRCEDGK-WTE-PPKCIEGQEKVA 335
K + + + + V C+ F + G + I C D W+ P+C KV
Sbjct: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC-----KVV 226
Query: 336 CEEPPFIENG--AANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PEC-- 389
P +ENG + K YY V + C G+ L GS+ I C + W P P+C
Sbjct: 227 KCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 390 VENNENCKHPPVVMNG--AVADGILAS 414
V + K P +G +GIL S
Sbjct: 286 VSTSSTTKSPASSASGYPKPEEGILDS 312
Score = 73.6 bits (179), Expect = 6e-13
Identities = 71/247 (28%), Positives = 104/247 (42%), Gaps = 28/247 (11%)
Query: 228 KQTYEEGDVVQFFCHENYYLS---GSDLIQCYNFGWYPESP-VCEGRRNRCPPPPLPINS 283
K YE G+ V + C + Y+ + I N W P S C R CP P+N
Sbjct: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACY--RETCPYIRDPLNG 108
Query: 284 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCE----DGKWT-EPPKCIEGQEKVACEE 338
+ + TY G +H C + + G + CE W+ +PP C EKV C
Sbjct: 109 QAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC----EKVLCTP 164
Query: 339 PPFIENGAANLHS-KIYYNGDKVTYACKSG-----YLLHGSNEITC-NRGKWT-LPPECV 390
PP I+NG +++ D VTY+C + L G + I C + W+ PEC
Sbjct: 165 PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC- 223
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPV- 449
C+ P VV NG G + ++V + C++ + L GS C+ PPV
Sbjct: 224 -KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 450 -CLEPCT 455
CL+ T
Sbjct: 282 KCLKVST 288
Score = 65.9 bits (159), Expect = 1e-10
Identities = 72/267 (26%), Positives = 110/267 (41%), Gaps = 20/267 (7%)
Query: 335 ACEEPPFIENGAANLHSKIYYN-GDKVTYACKSGYLLHG--SNEITCNRGKWTLP-PECV 390
ACEEPP E K YY G++V Y CK GY + C+R LP +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 391 ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCE-QGK---WSS 446
E C + +NG +Y G + + CNE Y L G +I CE +G WS
Sbjct: 94 CYRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSG 152
Query: 447 -PPVCLEP-CTVNVDYMN-RNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSV 503
PP+C + CT N ++ +E + D + + C P + + E ++
Sbjct: 153 KPPICEKVLCTPPPKIKNGKHTFSEVEVFE----YLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 504 QCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSR 563
C V E K + P++++G IS + ++V + C +L+GS
Sbjct: 209 YCGDNSVWSRAAP--ECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Query: 564 EAYC-LDGMWTTP-PLCLEPCTLSFTE 588
C + W P P CL+ T S T+
Sbjct: 267 TIVCDSNSTWDPPVPKCLKVSTSSTTK 293
Score = 55.8 bits (133), Expect = 1e-07
Identities = 62/260 (23%), Positives = 97/260 (37%), Gaps = 20/260 (7%)
Query: 101 ISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELY 159
I K Y+I E + Y C GY + + W ETC +
Sbjct: 47 IGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPL 106
Query: 160 NGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG----WS-LTPKCTKLKCS 214
NG T++ ++ + C GYY G E + C G WS P C K+ C+
Sbjct: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCT 163
Query: 215 SLRLIENG-YFHPVKQTYEEGDVVQFFCH-----ENYYLSGSDLIQC-YNFGWYPESPVC 267
I+NG + + +E D V + C + + L G I C N W +P C
Sbjct: 164 PPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC 223
Query: 268 EGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP--P 325
+ +C P + +I + + V EC+ F + GS I C+ +P P
Sbjct: 224 --KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
Query: 326 KCIEGQEKVACEEPPFIENG 345
KC++ + P +G
Sbjct: 282 KCLKVSTSSTTKSPASSASG 301
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/199 (26%), Positives = 82/199 (41%), Gaps = 31/199 (15%)
Query: 393 NENCKHPPVVMNGAVADGILASYATGSSVEYRCNE--YYLLRGSKISRCEQGK-WS--SP 447
++ C+ PP + Y G V+Y+C + +Y+ + + C++ W S
Sbjct: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
Query: 448 PVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
C E C D +N + YE G + F+C +GY L + E + C
Sbjct: 92 DACYRETCPYIRDPLNGQAVPANGTYE----FGYQMHFICNEGYYL-----IGEEILYCE 142
Query: 507 -RGEV-----KYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF-----D 555
+G V K P+C K +CT PP IK+G S V+ +E +V Y C D
Sbjct: 143 LKGSVAIWSGKPPIC----EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD 198
Query: 556 HHFLEGSREAYCLD-GMWT 573
L G YC D +W+
Sbjct: 199 PFSLIGESTIYCGDNSVWS 217
Score = 38.1 bits (87), Expect = 0.026
Identities = 51/178 (28%), Positives = 76/178 (42%), Gaps = 25/178 (14%)
Query: 54 KLSFFCLAGYTTESGRQEEQTTCTTEG----WSPEPRCFKK--CTKPD-LSNGY--ISDV 104
++ F C GY EE C +G WS +P +K CT P + NG S+V
Sbjct: 122 QMHFICNEGYYLIG---EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEV 178
Query: 105 KLLYKIQENMRYGC--ASGYKTTGGKDEEVVQCLSDG-WS-SQPTCRKEHETCLAPELYN 160
++ ++ + + Y C A G E + C + WS + P C+ C P + N
Sbjct: 179 EV-FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK--CRFPVVEN 235
Query: 161 GNY-STTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSS 215
G S K F K V +EC G+Y G ++ + C + W PKC K+ SS
Sbjct: 236 GKQISGFGKKFYYKATVMFECDKGFYLDG---SDTIVCDSNSTWDPPVPKCLKVSTSS 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,377,442
Number of Sequences: 37866
Number of extensions: 1604478
Number of successful extensions: 5216
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 3184
Number of HSP's gapped (non-prelim): 770
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.