Search of human proteins with 110611176

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
         (877 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ...  1763   0.0  
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur...  1251   0.0  
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur...  1251   0.0  
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]         1248   0.0  
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs...  1218   0.0  
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso...  1218   0.0  
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s...   733   0.0  
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs...   721   0.0  
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre...   632   0.0  
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr...   632   0.0  
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur...   608   e-174
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso...   608   e-174
gi|37577159 calcium-sensing receptor [Homo sapiens]                   408   e-113
gi|112807234 G protein-coupled receptor, family C, group 6, memb...   243   7e-64
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]          226   9e-59
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]         224   2e-58
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]           213   5e-55
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ...   200   4e-51
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]         122   1e-27
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]         119   9e-27
gi|40255245 G protein-coupled receptor 51 [Homo sapiens]               59   2e-08
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform...    53   1e-06
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    53   1e-06
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    53   1e-06
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]     53   1e-06
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]     53   1e-06
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]     53   1e-06
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]          50   1e-05
gi|7706451 G protein-coupled receptor, family C, group 5, member...    45   4e-04
gi|23308585 G protein-coupled receptor 156 [Homo sapiens]              41   0.004

>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
           sapiens]
          Length = 877

 Score = 1763 bits (4566), Expect = 0.0
 Identities = 877/877 (100%), Positives = 877/877 (100%)

Query: 1   MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL 60
           MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
Sbjct: 1   MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL 60

Query: 61  KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR 120
           KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
Sbjct: 61  KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR 120

Query: 121 GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE 180
           GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
Sbjct: 121 GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE 180

Query: 181 LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA 240
           LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
Sbjct: 181 LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA 240

Query: 241 GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH 300
           GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
Sbjct: 241 GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH 300

Query: 301 FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF 360
           FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
Sbjct: 301 FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF 360

Query: 361 WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ 420
           WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
Sbjct: 361 WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ 420

Query: 421 ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG 480
           ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
Sbjct: 421 ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG 480

Query: 481 SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC 540
           SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
Sbjct: 481 SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC 540

Query: 541 EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT 600
           EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
Sbjct: 541 EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT 600

Query: 601 TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG 660
           TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
Sbjct: 601 TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG 660

Query: 661 TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP 720
           TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
Sbjct: 661 TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP 720

Query: 721 PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN 780
           PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
Sbjct: 721 PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN 780

Query: 781 EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT 840
           EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
Sbjct: 781 EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT 840

Query: 841 YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK 877
           YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
Sbjct: 841 YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK 877


>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
           [Homo sapiens]
          Length = 908

 Score = 1251 bits (3236), Expect = 0.0
 Identities = 602/836 (72%), Positives = 701/836 (83%), Gaps = 9/836 (1%)

Query: 30  AGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGV 89
           A S+R+ G + LGGLFPVHA+G  G  CG+LKKE+G+HRLEAMLYA+D++N DP+LL  +
Sbjct: 37  AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96

Query: 90  RLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVV 149
            LG R+LDTCSRDTYALEQ+L+FVQALI    + D   V+C  G PP+    P+++  V+
Sbjct: 97  TLGVRILDTCSRDTYALEQSLTFVQALI----EKDASDVKCANGDPPIF-TKPDKISGVI 151

Query: 150 GASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVR 209
           GA+ASSVSIMVAN+LRLF IPQISYASTAPELSD+TRYDFFSRVVPPDSYQAQAMVDIV 
Sbjct: 152 GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVT 211

Query: 210 ALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
           ALGWNYVSTLASEGNYGESGVEAF QISRE GGVCIAQS KIPREP+PGEF K+I+RL+E
Sbjct: 212 ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271

Query: 270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITI 329
           TPNAR +I+FANEDDIRR+LEAA++ N +GHFLW+GSDSWG+K +P+   E++A GA+TI
Sbjct: 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTI 331

Query: 330 LPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERI 389
           LPKRASIDGFD+YF +R+L NNRRN+WFAEFWEENF CKL S G ++    +KCTG ERI
Sbjct: 332 LPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSH-IKKCTGLERI 390

Query: 390 GRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVR 449
            RDS+YEQEGKVQFVIDAVY++A+ALH+MH+ LCPG+ GLCP M   DG+ LL YIRAV 
Sbjct: 391 ARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN 450

Query: 450 FNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGD 509
           FNGSAGTPV FNENGDAPGRYDIFQYQ TN S     Y+ +G W   L L VE +QW+  
Sbjct: 451 FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTE---YKVIGHWTNQLHLKVEDMQWAHR 507

Query: 510 PHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHT 569
            H  P+S+CSLPC PGERKK VKGVPCCWHCE C+GY +QVDE +CE CP D RP  N T
Sbjct: 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRT 567

Query: 570 GCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLT 629
           GC+  P+++L W SPWA  P+ +A+LGI+ATT V+ TFVRYN+TPIVRASGRELSYVLLT
Sbjct: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627

Query: 630 GIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPP 689
           GIFL Y+ITFLM+A P   +C+ RR+FLGLG   SY+ALLTKTNRI+RIFEQGK+SVT P
Sbjct: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687

Query: 690 PFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDL 749
            FISP SQLVITFSL S+Q++G+  W    PPH +IDY EQRT+DPE+ARGVLKCD+SDL
Sbjct: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDL 747

Query: 750 SLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQS 809
           SLI  LGYS+LLMVTCTVYAIK RGVPETFNEAKPIGFTMYTTCIIWLAF+PIFFGTAQS
Sbjct: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807

Query: 810 AEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVA 865
           AEK+YIQTTTLTVS+SLSASVSLGMLY+PK Y+I+FHPEQNVQKRKRS KA  T A
Sbjct: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAA 863


>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
           [Homo sapiens]
          Length = 908

 Score = 1251 bits (3236), Expect = 0.0
 Identities = 602/836 (72%), Positives = 701/836 (83%), Gaps = 9/836 (1%)

Query: 30  AGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGV 89
           A S+R+ G + LGGLFPVHA+G  G  CG+LKKE+G+HRLEAMLYA+D++N DP+LL  +
Sbjct: 37  AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96

Query: 90  RLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVV 149
            LG R+LDTCSRDTYALEQ+L+FVQALI    + D   V+C  G PP+    P+++  V+
Sbjct: 97  TLGVRILDTCSRDTYALEQSLTFVQALI----EKDASDVKCANGDPPIF-TKPDKISGVI 151

Query: 150 GASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVR 209
           GA+ASSVSIMVAN+LRLF IPQISYASTAPELSD+TRYDFFSRVVPPDSYQAQAMVDIV 
Sbjct: 152 GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVT 211

Query: 210 ALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
           ALGWNYVSTLASEGNYGESGVEAF QISRE GGVCIAQS KIPREP+PGEF K+I+RL+E
Sbjct: 212 ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271

Query: 270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITI 329
           TPNAR +I+FANEDDIRR+LEAA++ N +GHFLW+GSDSWG+K +P+   E++A GA+TI
Sbjct: 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTI 331

Query: 330 LPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERI 389
           LPKRASIDGFD+YF +R+L NNRRN+WFAEFWEENF CKL S G ++    +KCTG ERI
Sbjct: 332 LPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSH-IKKCTGLERI 390

Query: 390 GRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVR 449
            RDS+YEQEGKVQFVIDAVY++A+ALH+MH+ LCPG+ GLCP M   DG+ LL YIRAV 
Sbjct: 391 ARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN 450

Query: 450 FNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGD 509
           FNGSAGTPV FNENGDAPGRYDIFQYQ TN S     Y+ +G W   L L VE +QW+  
Sbjct: 451 FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTE---YKVIGHWTNQLHLKVEDMQWAHR 507

Query: 510 PHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHT 569
            H  P+S+CSLPC PGERKK VKGVPCCWHCE C+GY +QVDE +CE CP D RP  N T
Sbjct: 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRT 567

Query: 570 GCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLT 629
           GC+  P+++L W SPWA  P+ +A+LGI+ATT V+ TFVRYN+TPIVRASGRELSYVLLT
Sbjct: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627

Query: 630 GIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPP 689
           GIFL Y+ITFLM+A P   +C+ RR+FLGLG   SY+ALLTKTNRI+RIFEQGK+SVT P
Sbjct: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687

Query: 690 PFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDL 749
            FISP SQLVITFSL S+Q++G+  W    PPH +IDY EQRT+DPE+ARGVLKCD+SDL
Sbjct: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDL 747

Query: 750 SLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQS 809
           SLI  LGYS+LLMVTCTVYAIK RGVPETFNEAKPIGFTMYTTCIIWLAF+PIFFGTAQS
Sbjct: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807

Query: 810 AEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVA 865
           AEK+YIQTTTLTVS+SLSASVSLGMLY+PK Y+I+FHPEQNVQKRKRS KA  T A
Sbjct: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAA 863


>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
          Length = 912

 Score = 1248 bits (3229), Expect = 0.0
 Identities = 606/864 (70%), Positives = 708/864 (81%), Gaps = 13/864 (1%)

Query: 7   AREPLLVALLPLAWLAQAGLARAAG-----SVRLAGGLTLGGLFPVHARGAAGRACGQLK 61
           AR PL + L        + L +  G     S+R+ G +TLGGLFPVH RG+ G+ CG+LK
Sbjct: 12  ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71

Query: 62  KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRG 121
           KE+G+HRLEAML+ALDR+N DP+LLP + LGAR+LDTCSRDT+ALEQ+L+FVQALI    
Sbjct: 72  KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-- 129

Query: 122 DGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPEL 181
           DG EV  RC  G PP+    PERVV V+GAS SSVSIMVAN+LRLF IPQISYASTAP+L
Sbjct: 130 DGTEV--RCGSGGPPII-TKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDL 186

Query: 182 SDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAG 241
           SD++RYDFFSRVVP D+YQAQAMVDIVRAL WNYVST+ASEG+YGESGVEAF+Q SRE G
Sbjct: 187 SDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDG 246

Query: 242 GVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHF 301
           GVCIAQS+KIPREPK GEF K+IRRL+ET NAR +IIFANEDDIRRVLEAAR+AN TGHF
Sbjct: 247 GVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHF 306

Query: 302 LWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFW 361
            W+GSDSWG+K +P+L LE+VA GA+TILPKR S+ GFD+YF +R+L+NNRRNIWFAEFW
Sbjct: 307 FWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFW 366

Query: 362 EENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQA 421
           E+NF+CKL+    +     +KCT  ERIG+DS YEQEGKVQFVIDAVYA+ HALH+MH+ 
Sbjct: 367 EDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRD 426

Query: 422 LCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGS 481
           LCPG  GLCP M+P DG  LL+YIR V F+G AG PV FNENGDAPGRYDI+QYQ  N S
Sbjct: 427 LCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDS 486

Query: 482 ASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCE 541
           A    Y+ +G W + L L +E + W G   ++P S+CSLPC PGERKK VKG+PCCWHCE
Sbjct: 487 AE---YKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCE 543

Query: 542 ACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATT 601
            C GY++QVD +TC+ CP DMRPT N TGCRP P+++L W SPWA  PL LAV+GI AT 
Sbjct: 544 PCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATL 603

Query: 602 TVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGT 661
            VV TFVRYN+TPIV+ASGRELSYVLL GIFL YA TFLM+AEP    C+ RR+FLGLG 
Sbjct: 604 FVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGM 663

Query: 662 TLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPP 721
           ++SY+ALLTKTNRIYRIFEQGKRSV+ P FISP SQL ITFSL SLQ++G+  W    P 
Sbjct: 664 SISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPS 723

Query: 722 HSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNE 781
           HSV+D+++QRT+DP  ARGVLKCD+SDLSLI  LGYS+LLMVTCTVYAIK RGVPETFNE
Sbjct: 724 HSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNE 783

Query: 782 AKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTY 841
           AKPIGFTMYTTCI+WLAF+PIFFGT+QSA+K+YIQTTTLTVS+SLSASVSLGMLY+PK Y
Sbjct: 784 AKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVY 843

Query: 842 VILFHPEQNVQKRKRSLKATSTVA 865
           +ILFHPEQNV KRKRSLKA  T A
Sbjct: 844 IILFHPEQNVPKRKRSLKAVVTAA 867


>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
           [Homo sapiens]
          Length = 922

 Score = 1218 bits (3152), Expect = 0.0
 Identities = 581/857 (67%), Positives = 710/857 (82%), Gaps = 9/857 (1%)

Query: 11  LLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE 70
           L V L  LA  A+     A  S+R+ G +TLGGLFPVHA+G +G  CG +K+E G+HRLE
Sbjct: 21  LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80

Query: 71  AMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC 130
           AMLYALD++N+DP LLP V LGAR+LDTCSRDTYALEQ+L+FVQALI+     D   VRC
Sbjct: 81  AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK----DTSDVRC 136

Query: 131 PGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFF 190
             G PP+    PE+VV V+GAS SSVSIMVAN+LRLF IPQISYASTAPELSD  RYDFF
Sbjct: 137 TNGEPPVF-VKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFF 195

Query: 191 SRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIK 250
           SRVVPPDS+QAQAMVDIV+ALGWNYVSTLASEG+YGE GVE+F QIS+EAGG+CIAQS++
Sbjct: 196 SRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVR 255

Query: 251 IPREPKPG--EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDS 308
           IP+E K    +F ++I++L++TPN+R ++IFAN++DI+++L AA++A+  GHFLWVGSDS
Sbjct: 256 IPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDS 315

Query: 309 WGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCK 368
           WG+K +P+   ED+A GAITI PKRA+++GFD YF +R+LENNRRN+WFAE+WEENFNCK
Sbjct: 316 WGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCK 375

Query: 369 LTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG 428
           LT SG++ +D+ RKCTG+ERIG+DS YEQEGKVQFVIDAVYA+AHALH M++ LC  + G
Sbjct: 376 LTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRG 435

Query: 429 LCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQ 488
           +CP ME   G+ LL+YIR V FNGSAGTPVMFN+NGDAPGRYDIFQYQ TN   S+ GY+
Sbjct: 436 VCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTN--TSNPGYR 493

Query: 489 AVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF 548
            +GQW + L+L++E +QW     E+P+S+C+LPC PG+RKK  KG PCCW CE CDGY++
Sbjct: 494 LIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQY 553

Query: 549 QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFV 608
           Q DE TC+ CP D RP  N TGC+  P+++L W SPWA  P+ LA+LGI+AT  V+ATF+
Sbjct: 554 QFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFI 613

Query: 609 RYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSAL 668
           RYN+TPIVRASGRELSYVLLTGIFL Y ITFLM+A+P  AVC+ RR+FLGLG  +SY+AL
Sbjct: 614 RYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAAL 673

Query: 669 LTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYE 728
           LTKTNRIYRIFEQGK+SVT P  ISPTSQL IT SL S+Q++G+  W G  PP+ +IDY+
Sbjct: 674 LTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYD 733

Query: 729 EQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFT 788
           E +T++PEQARGVLKCD++DL +I  LGYS+LLMVTCTVYAIK RGVPE FNEAKPIGFT
Sbjct: 734 EHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFT 793

Query: 789 MYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPE 848
           MYTTCI+WLAF+PIFFGTAQSAEK+YIQTTTLT+S++LSASV+LGMLY+PK Y+I+FHPE
Sbjct: 794 MYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853

Query: 849 QNVQKRKRSLKATSTVA 865
            NVQKRKRS KA  T A
Sbjct: 854 LNVQKRKRSFKAVVTAA 870


>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
           [Homo sapiens]
          Length = 915

 Score = 1218 bits (3152), Expect = 0.0
 Identities = 581/857 (67%), Positives = 710/857 (82%), Gaps = 9/857 (1%)

Query: 11  LLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE 70
           L V L  LA  A+     A  S+R+ G +TLGGLFPVHA+G +G  CG +K+E G+HRLE
Sbjct: 21  LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80

Query: 71  AMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC 130
           AMLYALD++N+DP LLP V LGAR+LDTCSRDTYALEQ+L+FVQALI+     D   VRC
Sbjct: 81  AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK----DTSDVRC 136

Query: 131 PGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFF 190
             G PP+    PE+VV V+GAS SSVSIMVAN+LRLF IPQISYASTAPELSD  RYDFF
Sbjct: 137 TNGEPPVF-VKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFF 195

Query: 191 SRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIK 250
           SRVVPPDS+QAQAMVDIV+ALGWNYVSTLASEG+YGE GVE+F QIS+EAGG+CIAQS++
Sbjct: 196 SRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVR 255

Query: 251 IPREPKPG--EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDS 308
           IP+E K    +F ++I++L++TPN+R ++IFAN++DI+++L AA++A+  GHFLWVGSDS
Sbjct: 256 IPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDS 315

Query: 309 WGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCK 368
           WG+K +P+   ED+A GAITI PKRA+++GFD YF +R+LENNRRN+WFAE+WEENFNCK
Sbjct: 316 WGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCK 375

Query: 369 LTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG 428
           LT SG++ +D+ RKCTG+ERIG+DS YEQEGKVQFVIDAVYA+AHALH M++ LC  + G
Sbjct: 376 LTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRG 435

Query: 429 LCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQ 488
           +CP ME   G+ LL+YIR V FNGSAGTPVMFN+NGDAPGRYDIFQYQ TN   S+ GY+
Sbjct: 436 VCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTN--TSNPGYR 493

Query: 489 AVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF 548
            +GQW + L+L++E +QW     E+P+S+C+LPC PG+RKK  KG PCCW CE CDGY++
Sbjct: 494 LIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQY 553

Query: 549 QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFV 608
           Q DE TC+ CP D RP  N TGC+  P+++L W SPWA  P+ LA+LGI+AT  V+ATF+
Sbjct: 554 QFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFI 613

Query: 609 RYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSAL 668
           RYN+TPIVRASGRELSYVLLTGIFL Y ITFLM+A+P  AVC+ RR+FLGLG  +SY+AL
Sbjct: 614 RYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAAL 673

Query: 669 LTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYE 728
           LTKTNRIYRIFEQGK+SVT P  ISPTSQL IT SL S+Q++G+  W G  PP+ +IDY+
Sbjct: 674 LTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYD 733

Query: 729 EQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFT 788
           E +T++PEQARGVLKCD++DL +I  LGYS+LLMVTCTVYAIK RGVPE FNEAKPIGFT
Sbjct: 734 EHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFT 793

Query: 789 MYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPE 848
           MYTTCI+WLAF+PIFFGTAQSAEK+YIQTTTLT+S++LSASV+LGMLY+PK Y+I+FHPE
Sbjct: 794 MYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853

Query: 849 QNVQKRKRSLKATSTVA 865
            NVQKRKRS KA  T A
Sbjct: 854 LNVQKRKRSFKAVVTAA 870


>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
           sapiens]
          Length = 879

 Score =  733 bits (1893), Expect = 0.0
 Identities = 387/837 (46%), Positives = 521/837 (62%), Gaps = 31/837 (3%)

Query: 33  VRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLG 92
           +++ G L LGGLFP++ +G     CG++ +++G+ RLEAML+A+D +N D  LLPGV+LG
Sbjct: 33  IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92

Query: 93  ARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGAS 152
             +LDTCSRDTYALEQ+L FV+A +      DE    CP G   ++   P  +  V+G S
Sbjct: 93  VHILDTCSRDTYALEQSLEFVRASLT---KVDEAEYMCPDGSYAIQENIPLLIAGVIGGS 149

Query: 153 ASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALG 212
            SSVSI VAN+LRLF IPQISYAST+ +LSD +RYD+F+R VPPD YQA+AM +I+R   
Sbjct: 150 YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFN 209

Query: 213 WNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPN 272
           W YVST+ASEG+YGE+G+EAF Q +R    +CIA + K+ R      +  VIR L++ PN
Sbjct: 210 WTYVSTVASEGDYGETGIEAFEQEAR-LRNICIATAEKVGRSNIRKSYDSVIRELLQKPN 268

Query: 273 ARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPK 332
           AR +++F   DD R ++ AA +AN +  F WV SD WGA+ S I   E VA GAIT+   
Sbjct: 269 ARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELA 326

Query: 333 RASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRD 392
              +  FD+YF + +  NN RN WF +FWE+ F C L     Q+  + R+   +      
Sbjct: 327 SQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL-----QNKRNHRRVCDKHLAIDS 381

Query: 393 STYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQ-YIRAVRF- 450
           S YEQE K+ FV++AVYA+AHALH M + LCP  T LC AM+  DG+ L + Y+  + F 
Sbjct: 382 SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFT 441

Query: 451 -----NGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQ 505
                N  A + V F+  GD  GRY++F +Q   G  S   Y  VG WAETL LDV ++ 
Sbjct: 442 APFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYS---YLKVGHWAETLSLDVNSIH 498

Query: 506 WSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPT 565
           WS +   VP+S CS PC P E K M  G  CCW C  C+ Y +  DEFTC  C     PT
Sbjct: 499 WSRN--SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPT 556

Query: 566 PNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSY 625
            + TGC   P   + W   WA  P+ +A LG + T  VV  F+++NNTP+V+ASGREL Y
Sbjct: 557 ADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCY 616

Query: 626 VLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRS 685
           +LL G+ L Y +TF  +A+P   +CA RRL LG    + YSALLTKTN I RIF+  K  
Sbjct: 617 ILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNG 676

Query: 686 VTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCD 745
              P FISP+SQ+ I   L  +Q+V +  WL    P +      + T+  ++   +LKC+
Sbjct: 677 AQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGT-----RRYTLAEKRETVILKCN 731

Query: 746 MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFG 805
           + D S++  L Y ++L++ CTVYA K R  PE FNEAK IGFTMYTTCIIWLAF+PIF+ 
Sbjct: 732 VKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYV 791

Query: 806 TAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATS 862
           T+       +QTTT+ +S+SLS  V LG L+ PK ++ILF P++NV   +  L   S
Sbjct: 792 TSSDYR---VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFS 845


>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
           [Homo sapiens]
          Length = 872

 Score =  721 bits (1860), Expect = 0.0
 Identities = 398/865 (46%), Positives = 520/865 (60%), Gaps = 41/865 (4%)

Query: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEA 71
           L+ALL L      G A+    + L G L LGGLFPVH +G     CG + + +G+ RLEA
Sbjct: 7   LLALLLLWGAVAEGPAKKV--LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEA 64

Query: 72  MLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCP 131
           ML+ALDR+N DP LLPGVRLGA +LD+CS+DT+ALEQAL FV+A +    DG      CP
Sbjct: 65  MLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRH--ICP 122

Query: 132 GGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFS 191
            G        P  +  V+G S S VSI VAN+LRLF IPQISYAST+ +LSD +RYD+F+
Sbjct: 123 DGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182

Query: 192 RVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKI 251
           R VPPD +QA+AM +I+R   W YVST+ASEG+YGE+G+EAF ++   A  +C+A S K+
Sbjct: 183 RTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAF-ELEARARNICVATSEKV 241

Query: 252 PREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGA 311
            R      F  V+R L++ P+AR  ++F   +D R +L A+++ N +  F WV SD WGA
Sbjct: 242 GRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGA 299

Query: 312 KTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTS 371
             S +   E  A GAITI      I  F  YF +    NN RN WF EFWE+ F C    
Sbjct: 300 LESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ 359

Query: 372 SGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCP 431
                    R C       R   +EQE K+ FV++AVYA+AHALH+MH+ALCP  T LC 
Sbjct: 360 ---------RDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCD 408

Query: 432 AMEPTDGRMLLQ-YIRAVRFNG-----SAGTPVMFNENGDAPGRYDIFQYQATNGSASSG 485
           AM P +GR L + ++  V+F+           V F+  GD  GRY+IF Y      A SG
Sbjct: 409 AMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLR----AGSG 464

Query: 486 GY--QAVGQWAETLRLDVEALQW-SGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEA 542
            Y  Q VG WAE L LD   + W S     +P+S CS PC   E K +  G  CCW C  
Sbjct: 465 RYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIP 524

Query: 543 CDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTT 602
           C  Y +++DEFTC  C     P  + TGC   P   + W   WA  P+ +A LG +AT  
Sbjct: 525 CQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLF 584

Query: 603 VVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTT 662
           V+  FVR+N TP+V+ASGREL Y+LL G+FL Y +TF+ +A+P  AVC  RRL LG   +
Sbjct: 585 VLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS 644

Query: 663 LSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPH 722
           + YSALLTKTNRI RIF   +     P FISP SQ+ I  +L S Q++ ++AWL    P 
Sbjct: 645 VCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPG 704

Query: 723 SVIDYEEQRTVDPEQARGV-LKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNE 781
           +       +   PE+   V L+C+  D S++G L Y++LL+  CT+YA K R  PE FNE
Sbjct: 705 T------GKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNE 758

Query: 782 AKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTY 841
           AK IGFTMYTTCIIWLAF+PIF+ T+       +QTTT+ VS+SLS SV LG L+ PK +
Sbjct: 759 AKFIGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCVSVSLSGSVVLGCLFAPKLH 815

Query: 842 VILFHPEQNVQKRKRSLKATSTVAA 866
           +ILF P++NV   +       + AA
Sbjct: 816 IILFQPQKNVVSHRAPTSRFGSAAA 840


>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
           precursor [Homo sapiens]
          Length = 906

 Score =  632 bits (1631), Expect = 0.0
 Identities = 361/875 (41%), Positives = 515/875 (58%), Gaps = 40/875 (4%)

Query: 11  LLVALLPLA---WLAQAGLARAAGSVRLAGGLTLGGLFPVH----ARGAAGRACGQLKKE 63
           L V+LLP +    +  AG +      R+ G + +G LF VH    A     R CG+++++
Sbjct: 14  LEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQ 73

Query: 64  QGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQ-ALIRGRGD 122
            G+ R+EAM + LD++NADP LLP + LG+ + D+C   + ALEQ++ F++ +LI  R +
Sbjct: 74  YGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDE 133

Query: 123 GDEVGVRCPGG--VPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE 180
            D +    P G  +PP R   P  +  V+G  +SSV+I V N+L+LF IPQI+Y++T+ +
Sbjct: 134 KDGINRCLPDGQSLPPGRTKKP--IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSID 191

Query: 181 LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA 240
           LSD T Y +F RVVP D+ QA+AM+DIV+   W YVS + +EGNYGESG++AF +++ + 
Sbjct: 192 LSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE 251

Query: 241 GGVCIAQSIKIPREPKPGEFSKVIRRLMET-PNARGIIIFANEDDIRRVLEAARQANLTG 299
           G +CIA S KI        F +++R+L E  P AR ++ F     +R +L A R+  + G
Sbjct: 252 G-LCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVG 310

Query: 300 HFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAE 359
            F  +GSD W  +   I   E  A G ITI  +   +  FD YF+   L+ N RN WF E
Sbjct: 311 EFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPE 370

Query: 360 FWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMH 419
           FW+  F C+L     ++ +  R CTG E +  +  Y Q+ K+ FVI+A+YA+AH L +MH
Sbjct: 371 FWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFVINAIYAMAHGLQNMH 428

Query: 420 QALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATN 479
            ALCPGH GLC AM+P DG  LL ++    F G +G  V F+E GDAPGRYDI   Q T 
Sbjct: 429 HALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTE 488

Query: 480 GSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKG-VPCCW 538
             A+   Y  VG W E + L+++  +   +   V  S+CS PC  G+ K + KG V CCW
Sbjct: 489 --ANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCW 545

Query: 539 HCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIV 598
            C AC    +  DEFTC+AC     P  + TGC P PV  L WS+  +   +  + LGI+
Sbjct: 546 ICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGIL 605

Query: 599 ATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLG 658
            T  V   FV Y +TP+V++S REL Y++L GIFL Y   F ++A+P    C  +RL +G
Sbjct: 606 VTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVG 665

Query: 659 LGTTLSYSALLTKTNRIYRIFEQGKRSV--TPPPFISPTSQLVITFSLTSLQVVGMIAWL 716
           L + + YSAL+TKTNRI RI    K+ +    P F+S  +Q++I   L S+Q+  ++  +
Sbjct: 666 LSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI 725

Query: 717 GARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVP 776
              PP  ++ Y   + V        L C+ S+L ++  LGY+ LL+++CT YA K R VP
Sbjct: 726 IMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVP 778

Query: 777 ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLY 836
             FNEAK I FTMYTTCIIWLAFVPI+FG+        I TT   VSLS+  +V+LG ++
Sbjct: 779 ANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVSLSV--TVALGCMF 831

Query: 837 VPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGE 871
            PK Y+I+  PE+NV    RS   TS V     G+
Sbjct: 832 TPKMYIIIAKPERNV----RSAFTTSDVVRMHVGD 862


>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
           precursor [Homo sapiens]
          Length = 1194

 Score =  632 bits (1631), Expect = 0.0
 Identities = 361/875 (41%), Positives = 515/875 (58%), Gaps = 40/875 (4%)

Query: 11  LLVALLPLA---WLAQAGLARAAGSVRLAGGLTLGGLFPVH----ARGAAGRACGQLKKE 63
           L V+LLP +    +  AG +      R+ G + +G LF VH    A     R CG+++++
Sbjct: 14  LEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQ 73

Query: 64  QGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQ-ALIRGRGD 122
            G+ R+EAM + LD++NADP LLP + LG+ + D+C   + ALEQ++ F++ +LI  R +
Sbjct: 74  YGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDE 133

Query: 123 GDEVGVRCPGG--VPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE 180
            D +    P G  +PP R   P  +  V+G  +SSV+I V N+L+LF IPQI+Y++T+ +
Sbjct: 134 KDGINRCLPDGQSLPPGRTKKP--IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSID 191

Query: 181 LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA 240
           LSD T Y +F RVVP D+ QA+AM+DIV+   W YVS + +EGNYGESG++AF +++ + 
Sbjct: 192 LSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE 251

Query: 241 GGVCIAQSIKIPREPKPGEFSKVIRRLMET-PNARGIIIFANEDDIRRVLEAARQANLTG 299
           G +CIA S KI        F +++R+L E  P AR ++ F     +R +L A R+  + G
Sbjct: 252 G-LCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVG 310

Query: 300 HFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAE 359
            F  +GSD W  +   I   E  A G ITI  +   +  FD YF+   L+ N RN WF E
Sbjct: 311 EFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPE 370

Query: 360 FWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMH 419
           FW+  F C+L     ++ +  R CTG E +  +  Y Q+ K+ FVI+A+YA+AH L +MH
Sbjct: 371 FWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFVINAIYAMAHGLQNMH 428

Query: 420 QALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATN 479
            ALCPGH GLC AM+P DG  LL ++    F G +G  V F+E GDAPGRYDI   Q T 
Sbjct: 429 HALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTE 488

Query: 480 GSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKG-VPCCW 538
             A+   Y  VG W E + L+++  +   +   V  S+CS PC  G+ K + KG V CCW
Sbjct: 489 --ANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCW 545

Query: 539 HCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIV 598
            C AC    +  DEFTC+AC     P  + TGC P PV  L WS+  +   +  + LGI+
Sbjct: 546 ICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGIL 605

Query: 599 ATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLG 658
            T  V   FV Y +TP+V++S REL Y++L GIFL Y   F ++A+P    C  +RL +G
Sbjct: 606 VTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVG 665

Query: 659 LGTTLSYSALLTKTNRIYRIFEQGKRSV--TPPPFISPTSQLVITFSLTSLQVVGMIAWL 716
           L + + YSAL+TKTNRI RI    K+ +    P F+S  +Q++I   L S+Q+  ++  +
Sbjct: 666 LSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI 725

Query: 717 GARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVP 776
              PP  ++ Y   + V        L C+ S+L ++  LGY+ LL+++CT YA K R VP
Sbjct: 726 IMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVP 778

Query: 777 ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLY 836
             FNEAK I FTMYTTCIIWLAFVPI+FG+        I TT   VSLS+  +V+LG ++
Sbjct: 779 ANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVSLSV--TVALGCMF 831

Query: 837 VPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGE 871
            PK Y+I+  PE+NV    RS   TS V     G+
Sbjct: 832 TPKMYIIIAKPERNV----RSAFTTSDVVRMHVGD 862


>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
           [Homo sapiens]
          Length = 1212

 Score =  608 bits (1569), Expect = e-174
 Identities = 345/847 (40%), Positives = 496/847 (58%), Gaps = 38/847 (4%)

Query: 35  LAGGLTLGGLFPVHARGAAG----RACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVR 90
           + G + +G LF VH +        R CG ++++ G+ R+EAML+ L+R+N+DP LLP + 
Sbjct: 31  MPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNIT 90

Query: 91  LGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC-PGGVPPLRPAPPERVVAVV 149
           LG  + D+C     ALEQ++ F++  +    + +E  VRC  G     R   P  +V V+
Sbjct: 91  LGCEIRDSCWHSAVALEQSIEFIRDSLIS-SEEEEGLVRCVDGSSSSFRSKKP--IVGVI 147

Query: 150 GASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVR 209
           G  +SSV+I V N+L+LF IPQI+Y++T+ +LSD T + +F RVVP D+ QA+AMVDIV+
Sbjct: 148 GPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVK 207

Query: 210 ALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
              W YVS + +EGNYGESG+EAF  +S + G +CIA S KI        F K++++L  
Sbjct: 208 RYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAHSYKIYSNAGEQSFDKLLKKLTS 266

Query: 270 -TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAIT 328
             P AR +  F     +R +L A R+  L G FL +GSD W  +       +  AVG IT
Sbjct: 267 HLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGIT 326

Query: 329 ILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEER 388
           I  +   +  FD Y++    E N RN WF EFW+  F C+L   G   ++S    T    
Sbjct: 327 IKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL--EGFPQENSKYNKTCNSS 384

Query: 389 IGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAV 448
           +   + + Q+ K+ FVI+A+Y++A+ LH+M  +LCPG+ GLC AM+P DGR LL+ +   
Sbjct: 385 LTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKT 444

Query: 449 RFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAE-TLRLDVEALQWS 507
            F G +G  ++F+ENGD+PGRY+I  ++          Y  VG W    L++D + + WS
Sbjct: 445 NFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD--YINVGSWDNGELKMDDDEV-WS 501

Query: 508 GDPHEVPSSLCSLPCGPGERKKMVKG-VPCCWHCEACDGYRFQVDEFTCEACPGDMRPTP 566
              + +  S+CS PC  G+ K + KG V CCW C  C    +  DE+TC+AC     PT 
Sbjct: 502 KKSNII-RSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTD 560

Query: 567 NHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYV 626
           + TGC   PV  L W  P     ++ A LG++AT  V   F+ Y +TP+V++S REL Y+
Sbjct: 561 DLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYI 620

Query: 627 LLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSV 686
           +L GI L Y  TF ++A+P    C  +R+ +GL   +SYSAL+TKTNRI RI    K+ +
Sbjct: 621 ILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKI 680

Query: 687 --TPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKC 744
               P F+S  +QLVI F L  +Q+  ++A     PP  + DY   R V        L C
Sbjct: 681 CTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREV-------YLIC 733

Query: 745 DMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFF 804
           + ++L ++  LGY+ LL+++CT YA K R VP  FNEAK I FTMYTTCIIWLAFVPI+F
Sbjct: 734 NTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF 793

Query: 805 GTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTV 864
           G+         +  T+  S+SLSA+V+LG ++VPK Y+IL  PE+NV    RS   TSTV
Sbjct: 794 GS-------NYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNV----RSAFTTSTV 842

Query: 865 AAPPKGE 871
                G+
Sbjct: 843 VRMHVGD 849


>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
           [Homo sapiens]
          Length = 1180

 Score =  608 bits (1569), Expect = e-174
 Identities = 345/847 (40%), Positives = 496/847 (58%), Gaps = 38/847 (4%)

Query: 35  LAGGLTLGGLFPVHARGAAG----RACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVR 90
           + G + +G LF VH +        R CG ++++ G+ R+EAML+ L+R+N+DP LLP + 
Sbjct: 31  MPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNIT 90

Query: 91  LGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC-PGGVPPLRPAPPERVVAVV 149
           LG  + D+C     ALEQ++ F++  +    + +E  VRC  G     R   P  +V V+
Sbjct: 91  LGCEIRDSCWHSAVALEQSIEFIRDSLIS-SEEEEGLVRCVDGSSSSFRSKKP--IVGVI 147

Query: 150 GASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVR 209
           G  +SSV+I V N+L+LF IPQI+Y++T+ +LSD T + +F RVVP D+ QA+AMVDIV+
Sbjct: 148 GPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVK 207

Query: 210 ALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269
              W YVS + +EGNYGESG+EAF  +S + G +CIA S KI        F K++++L  
Sbjct: 208 RYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAHSYKIYSNAGEQSFDKLLKKLTS 266

Query: 270 -TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAIT 328
             P AR +  F     +R +L A R+  L G FL +GSD W  +       +  AVG IT
Sbjct: 267 HLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGIT 326

Query: 329 ILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEER 388
           I  +   +  FD Y++    E N RN WF EFW+  F C+L   G   ++S    T    
Sbjct: 327 IKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL--EGFPQENSKYNKTCNSS 384

Query: 389 IGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAV 448
           +   + + Q+ K+ FVI+A+Y++A+ LH+M  +LCPG+ GLC AM+P DGR LL+ +   
Sbjct: 385 LTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKT 444

Query: 449 RFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAE-TLRLDVEALQWS 507
            F G +G  ++F+ENGD+PGRY+I  ++          Y  VG W    L++D + + WS
Sbjct: 445 NFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD--YINVGSWDNGELKMDDDEV-WS 501

Query: 508 GDPHEVPSSLCSLPCGPGERKKMVKG-VPCCWHCEACDGYRFQVDEFTCEACPGDMRPTP 566
              + +  S+CS PC  G+ K + KG V CCW C  C    +  DE+TC+AC     PT 
Sbjct: 502 KKSNII-RSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTD 560

Query: 567 NHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYV 626
           + TGC   PV  L W  P     ++ A LG++AT  V   F+ Y +TP+V++S REL Y+
Sbjct: 561 DLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYI 620

Query: 627 LLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSV 686
           +L GI L Y  TF ++A+P    C  +R+ +GL   +SYSAL+TKTNRI RI    K+ +
Sbjct: 621 ILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKI 680

Query: 687 --TPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKC 744
               P F+S  +QLVI F L  +Q+  ++A     PP  + DY   R V        L C
Sbjct: 681 CTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREV-------YLIC 733

Query: 745 DMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFF 804
           + ++L ++  LGY+ LL+++CT YA K R VP  FNEAK I FTMYTTCIIWLAFVPI+F
Sbjct: 734 NTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF 793

Query: 805 GTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTV 864
           G+         +  T+  S+SLSA+V+LG ++VPK Y+IL  PE+NV    RS   TSTV
Sbjct: 794 GS-------NYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNV----RSAFTTSTV 842

Query: 865 AAPPKGE 871
                G+
Sbjct: 843 VRMHVGD 849


>gi|37577159 calcium-sensing receptor [Homo sapiens]
          Length = 1078

 Score =  408 bits (1048), Expect = e-113
 Identities = 280/870 (32%), Positives = 421/870 (48%), Gaps = 76/870 (8%)

Query: 37  GGLTLGGLFPVHARGAAGRACGQLKKE---------QGVHRLEAMLYALDRVNADPELLP 87
           G + LGGLFP+H   AA     + + E         +G   L+AM++A++ +N+ P LLP
Sbjct: 30  GDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLP 89

Query: 88  GVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVA 147
            + LG R+ DTC+  + ALE  LSFV        + DE    C   +P          +A
Sbjct: 90  NLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF-CNCSEHIPS--------TIA 140

Query: 148 VVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDI 207
           VVGA+ S VS  VAN+L LF IPQ+SYAS++  LS+  ++  F R +P D +QA AM DI
Sbjct: 141 VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADI 200

Query: 208 VRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRL 267
           +    WN+V T+A++ +YG  G+E F + + E   +CI  S  I +     E   V+  +
Sbjct: 201 IEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD-ICIDFSELISQYSDEEEIQHVVE-V 258

Query: 268 METPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLED---VAV 324
           ++   A+ I++F++  D+  +++   + N+TG  +W+ S++W +  S ++++     V  
Sbjct: 259 IQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASEAWAS--SSLIAMPQYFHVVG 315

Query: 325 GAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTS------------- 371
           G I    K   I GF ++        +  N +  EFWEE FNC L               
Sbjct: 316 GTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLR 375

Query: 372 ----SGTQSDDSTRK----CTGEERIGRDST----YEQEGKVQFVIDAVYAIAHALHSMH 419
               SG +  +S+      CTG+E I    T    Y        V  AVY+IAHAL  ++
Sbjct: 376 GHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIY 435

Query: 420 QALCPGH----TGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQY 475
             L PG      G C  ++  +   +L+++R + F  + G  V F+E GD  G Y I  +
Sbjct: 436 TCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINW 494

Query: 476 QATNGSASS-----GGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKM 530
             +    S      G Y    +  E L ++ E + WSG   EVP S CS  C  G RK +
Sbjct: 495 HLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGI 554

Query: 531 VKGVP-CCWHCEAC-DG-YRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAA 587
           ++G P CC+ C  C DG Y  + D   C  CP D     NHT C    +  LSW+ P+  
Sbjct: 555 IEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGI 614

Query: 588 PPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGA 647
              L AVLGI  T  V+  F+++ NTPIV+A+ RELSY+LL  +   ++ +   + EP  
Sbjct: 615 ALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQD 674

Query: 648 AVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSL 707
             C  R+   G+   L  S +L KTNR+  +FE    +     +     Q ++ F  T +
Sbjct: 675 WTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFM 734

Query: 708 QVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCL-GYSLLLMVTCT 766
           Q+V  + WL   PP S       R  + E     + C    L  +G L GY+ LL   C 
Sbjct: 735 QIVICVIWLYTAPPSS------YRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICF 788

Query: 767 VYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSL 826
            +A K+R +PE FNEAK I F+M    I+W++F+P +  T             L  S  L
Sbjct: 789 FFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGL 848

Query: 827 SASVSLGMLYVPKTYVILFHPEQNVQKRKR 856
                L  ++  K Y+ILF P +N  +  R
Sbjct: 849 -----LACIFFNKIYIILFKPSRNTIEEVR 873


>gi|112807234 G protein-coupled receptor, family C, group 6, member
           A [Homo sapiens]
          Length = 926

 Score =  243 bits (619), Expect = 7e-64
 Identities = 230/885 (25%), Positives = 386/885 (43%), Gaps = 93/885 (10%)

Query: 37  GGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE--------AMLYALDRVNADPELLPG 88
           G + +GGLF +H +  +     +  + Q     E        AM+++++ +N +  LLPG
Sbjct: 34  GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMIN-NSTLLPG 92

Query: 89  VRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAV 148
           V+LG  + DTC+  T A+   L F+      R   + V  +C         +   RV AV
Sbjct: 93  VKLGYEIYDTCTEVTVAMAATLRFLSKFNCSR---ETVEFKCDYS------SYMPRVKAV 143

Query: 149 VGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIV 208
           +G+  S +++ V+ +L L  +PQ+ Y STA  LSD  R+  F R VP D +Q +AM  ++
Sbjct: 144 IGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLI 203

Query: 209 RALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPG----EFSKVI 264
           +  GWN++  + ++ +YG   +  F+ I  EA  VCIA    +P            ++ +
Sbjct: 204 QKSGWNWIGIITTDDDYGRLALNTFI-IQAEANNVCIAFKEVLPAFLSDNTIEVRINRTL 262

Query: 265 RRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVA- 323
           ++++       I++F  +  +  +   A + N+    +W+ SD+W   T  I ++ +V  
Sbjct: 263 KKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK--MWIASDNWSTATK-ITTIPNVKK 319

Query: 324 VGAITILP-KRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSD----- 377
           +G +     +R +I  F  +     L  +  +    E+      C        S      
Sbjct: 320 IGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNH 379

Query: 378 -DSTRKCTGEERIGRDST--------YEQEGKVQFVIDAVYAIAHALHSMHQAL-CPGHT 427
              T      + I R+          Y + G +  +  AV+A+ +A+  + QA  C    
Sbjct: 380 SQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPN 439

Query: 428 GLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGY 487
               A +P +   LL  ++ V F     +   F+ +GD    YD+  ++  NG      +
Sbjct: 440 ----AFQPWE---LLGVLKNVTFTDGWNS-FHFDAHGDLNTGYDVVLWKEING------H 485

Query: 488 QAVGQWAE-TLRLDVEALQWSGDPHEVPS-----SLCSLPCGPGERKKMVKGVP-CCWHC 540
             V + AE  L+ DV  +      +E  +     S CS  C PG+ KK  +    CC+ C
Sbjct: 486 MTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYEC 545

Query: 541 EAC--DGYRFQVDEFTCEACPGDMRPTP-NHTGCRPTPVVRLSWSSPWAAPPLLLAVLGI 597
           + C  + Y  Q D   C  C       P   T C    V  L+W+   A   L+L++LGI
Sbjct: 546 QNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGI 605

Query: 598 VATTTVVATFVRYNNTPIVRASGR-ELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLF 656
           +    V   F R  NTP+V++SG   + YV+L   FL +A T   + EP    C  R+  
Sbjct: 606 IFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTM 665

Query: 657 LGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQ-LVITFSLTSLQVVGMIAW 715
            G+  TL  S +LTK+ +I   F    +      F+    + ++I F+ T +QVV    W
Sbjct: 666 FGVSFTLCISCILTKSLKILLAFSFDPKL---QKFLKCLYRPILIIFTCTGIQVVICTLW 722

Query: 716 LGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIG-CLGYSLLLMVTCTVYAIKARG 774
           L    P   ++    R +       +L+C+   +   G  LGY  +L   C ++A K  G
Sbjct: 723 LIFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--G 773

Query: 775 VPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGM 834
             E +NEAK I F M    I W+ F+PI+  T       Y+    + V L  +  + L  
Sbjct: 774 KYENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIVILISNYGI-LYC 828

Query: 835 LYVPKTYVILFHPEQNVQKR------KRSLKATSTVAAPPKGEDA 873
            ++PK YVI+   E N +          S  + S++A  P   D+
Sbjct: 829 TFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDS 873


>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
          Length = 839

 Score =  226 bits (575), Expect = 9e-59
 Identities = 224/855 (26%), Positives = 374/855 (43%), Gaps = 100/855 (11%)

Query: 35  LAGGLTLGGLFPVHA--RGAAGRACGQLK-------KEQGVHRLEAMLYALDRVNADPEL 85
           L G   LGGLF +HA  +G       Q+        K  G + ++AM +A++ +N D  L
Sbjct: 29  LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88

Query: 86  LPGVRLGARLLDTC--SRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPE 143
           LPGV LG  ++D C  S +   +   L+    L+  + D                     
Sbjct: 89  LPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNY---------------IS 133

Query: 144 RVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQA 203
           RVVAV+G   S   + VAN L LF +PQI+Y++ + EL D  R+    R  P   +  +A
Sbjct: 134 RVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEA 193

Query: 204 MVDIVRALGWNYVSTLASEGNYG-ESGVEAFVQISREAGGVCIAQSIKIPR-EPKPGEFS 261
           MV ++    WN++  L S   YG ++G     +++R    +CIA    +P  +P     S
Sbjct: 194 MVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DICIAFQETLPTLQPNQNMTS 251

Query: 262 KVIRRL------METPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSP 315
           +  +RL      ++   AR +++F+ +  +        + N TG  +W+ S+SW     P
Sbjct: 252 EERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTG-AVWIASESWA--IDP 308

Query: 316 IL-SLEDVA-VGA-ITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSS 372
           +L +L ++  +G  + I  +   I GF ++               ++ +  N  C    +
Sbjct: 309 VLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLN 368

Query: 373 GTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPA 432
            T S ++  + +GE              V  V  AVYA+AHALHS+    C   T     
Sbjct: 369 ATLSFNTILRLSGER------------VVYSVYSAVYAVAHALHSL--LGCDKSTCTKRV 414

Query: 433 MEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQ 492
           + P     LL+ I  V F       + F+  GD     +I Q+Q      S   +Q+V  
Sbjct: 415 VYPW---QLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQ---WDRSQNPFQSVAS 467

Query: 493 WAETLR--LDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF-- 548
           +    R   +++ + W    + +P S+CS  C  G++KK V    CC+ C  C    F  
Sbjct: 468 YYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLN 527

Query: 549 -QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATF 607
              DE+ C+ACP +     + T C    +V L W         LLA LG ++T  ++  F
Sbjct: 528 HTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIF 587

Query: 608 VRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSA 667
            R+  TPIVR++G  + +++LT + + Y +  + V  P  + C  R+    L  T+  S 
Sbjct: 588 WRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISC 647

Query: 668 LLTKTNRIYRIFEQGKRSVT--------PPPFISPTSQLVITFSLTSLQVVGMIAWLGAR 719
           +  ++ +I   F+   R             P++   S   IT     + V+GM+A  G  
Sbjct: 648 IAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYV---SMAFITVLKMVIVVIGMLA-TGLS 703

Query: 720 PPHSVIDYEEQRTVDPEQARGVLKCDMS-DLSLIGCLGYSLLLMVTCTVYAIKARGVPET 778
           P          RT   +    ++ C+ +   SL+      LLL V    +A   + +P  
Sbjct: 704 P--------TTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTN 755

Query: 779 FNEAKPIGFTM---YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGML 835
           +NEAK I  +M   +T+ +    F+  + G       + +    L V++    ++SLG  
Sbjct: 756 YNEAKFITLSMTFYFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-Y 807

Query: 836 YVPKTYVILFHPEQN 850
           + PK Y+ILF+PE+N
Sbjct: 808 FGPKCYMILFYPERN 822


>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
          Length = 841

 Score =  224 bits (572), Expect = 2e-58
 Identities = 226/876 (25%), Positives = 371/876 (42%), Gaps = 101/876 (11%)

Query: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
           L  L+   W        ++    L G   L GLFP+H+               R+C    
Sbjct: 11  LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68

Query: 62  KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS--RDTYALEQALSFV-QALIR 118
            E G H  +AM   ++ +N    LLP + LG +L D CS   + YA  + LS   Q  I 
Sbjct: 69  NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128

Query: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTA 178
            +GD              L  +P   V+AV+G  +++ +   A +L  F +P ISYA+++
Sbjct: 129 LQGD-------------LLHYSPT--VLAVIGPDSTNRAATTAALLSPFLVPMISYAASS 173

Query: 179 PELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISR 238
             LS   +Y  F R +P D YQ + MV +++  GW ++S + S  +YG+ GV+A ++   
Sbjct: 174 ETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQA-LENQA 232

Query: 239 EAGGVCIAQSIKIPREPKPG-EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANL 297
              G+CIA    +P   + G E  + + R +    A  +++F++    R   E+    NL
Sbjct: 233 TGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNL 292

Query: 298 TGHFLWVGSDSWGAKT--SPILSLEDVAVGAITILPKRA--SIDGFDQYFMTRSLENNRR 353
           TG  +WV S++W      + +  ++ + +     + KRA   +  F++ +  R+ +   R
Sbjct: 293 TGK-VWVASEAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAY-ARADKKAPR 350

Query: 354 NIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAH 413
                 +   N  C+   +         K          S Y           AVYA+AH
Sbjct: 351 PCHKGSWCSSNQLCRECQAFMAHTMPKLKA-----FSMSSAYN-------AYRAVYAVAH 398

Query: 414 ALHSMHQALCPGHTGLCPAMEPTDGRM----LLQYIRAVRFNGSAGTPVMFNENGDAPGR 469
            LH +        +G C     + GR+    LL+ I  V F     T V FN+N D    
Sbjct: 399 GLHQLLGCA----SGAC-----SRGRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSS 448

Query: 470 YDIFQYQATNGSASSGGYQAVGQWAET-LRLDVEALQWSGDPHEVPSSLCSLPCGPGERK 528
           Y+I  +   NG   +        W+   L ++   +QW G  ++VP S+CS  C  G ++
Sbjct: 449 YNIIAWD-WNGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQR 507

Query: 529 KMVKGVPCCWHCEACDGYRF--QVDEFTCEACPGDMRPTPNHTGCRPTPVVRL------S 580
            +     CC+ C  C    F  + D + C+ C  +         C P  VV L      S
Sbjct: 508 VVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTS 567

Query: 581 WSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFL 640
           W    A   LLL +LG          F  + +TP+VR++G  L +++L  +       + 
Sbjct: 568 WVLLAANTLLLLLLLG------TAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYG 621

Query: 641 MVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQ--- 697
              EP    C  R+    LG T+  S L  ++ ++  IF   K S   P F     Q   
Sbjct: 622 FFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHG 678

Query: 698 --LVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKC-DMSDLSLIGC 754
             L +  S ++ Q++  + WL    P    +Y+    +       +L+C + + L  I  
Sbjct: 679 AGLFVMIS-SAAQLLICLTWLVVWTPLPAREYQRFPHL------VMLECTETNSLGFILA 731

Query: 755 LGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIY 814
             Y+ LL ++    +   + +PE +NEAK + F++    + W+A    FF TA   +  Y
Sbjct: 732 FLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKY 787

Query: 815 IQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQN 850
           +    +   LS S S   G  ++PK YVIL  P+ N
Sbjct: 788 LPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLN 822


>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
          Length = 852

 Score =  213 bits (543), Expect = 5e-55
 Identities = 209/846 (24%), Positives = 361/846 (42%), Gaps = 78/846 (9%)

Query: 33  VRLAGGLTLGGLFPVHARGAAGR---------ACGQLKKEQGVHRLEAMLYALDRVNADP 83
           +R+ G   LGGLFP+     AG           C +     G+    AM  A++ +N   
Sbjct: 29  LRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSN-GLLWALAMKMAVEEINNKS 87

Query: 84  ELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPE 143
           +LLPG+RLG  L DTCS    A++ +L F+      +    ++   C       +P    
Sbjct: 88  DLLPGLRLGYDLFDTCSEPVVAMKPSLMFL-----AKAGSRDIAAYC--NYTQYQP---- 136

Query: 144 RVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQA 203
           RV+AV+G  +S ++++       F +PQ+SY ++   LS    +  F R VP D  Q  A
Sbjct: 137 RVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTA 196

Query: 204 MVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQS--IKIPR--EPKPGE 259
             ++++  GWN+V+ L S+  YG  G+  F  ++  A G+CIA    + +PR  + + G+
Sbjct: 197 AAELLQEFGWNWVAALGSDDEYGRQGLSIFSALA-AARGICIAHEGLVPLPRADDSRLGK 255

Query: 260 FSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSL 319
              V+ ++ ++ + + +++FA+      +   +  + L+   +WV S++W   +  ++ L
Sbjct: 256 VQDVLHQVNQS-SVQVVLLFASVHAAHALFNYSISSRLSPK-VWVASEAW-LTSDLVMGL 312

Query: 320 EDVA-VGAIT-ILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKL--TSSGTQ 375
             +A +G +   L + A +  F QY  T            A   +  F   L     G +
Sbjct: 313 PGMAQMGTVLGFLQRGAQLHEFPQYVKTH----------LALATDPAFCSALGEREQGLE 362

Query: 376 SDDSTRKCTGEERIGRD--STYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAM 433
            D   ++C   + I     S      +   V  AVY++A ALH+  Q    G    CPA 
Sbjct: 363 EDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASG----CPAQ 418

Query: 434 EPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQW 493
           +P     LL+ +  + F+   G P+ F+ +G+    YD+ +     GS        VG++
Sbjct: 419 DPVKPWQLLENMYNLTFH-VGGLPLRFDSSGNVDMEYDL-KLWVWQGSVPR--LHDVGRF 474

Query: 494 AETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACD--GYRFQVD 551
             +LR +   ++W    ++ P S CS  C  G+ +++     CC+ C  C+   YR   D
Sbjct: 475 NGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPD 534

Query: 552 EFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYN 611
           +  C  C  D       T C       L+W  P     LLL  L +      +  FV + 
Sbjct: 535 DIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHR 594

Query: 612 NTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTK 671
           ++P+V+ASG  L+   L  + L+     L   +P  A C A++    L  T   S L  +
Sbjct: 595 DSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQ 654

Query: 672 TNRIYRIFEQGKRSVTPPPFIS-----PTSQLVITFSLTSLQVVGMIAW-LGARPPHSVI 725
                 IF + +  ++    +S     P + LV+   L  L  V +  W L A PP  V 
Sbjct: 655 A---AEIFVESELPLSWADRLSGCLRGPWAWLVVL--LAMLVEVALCTWYLVAFPPEVVT 709

Query: 726 DYEEQRTVDPEQARGVLKCDMSDLSLIGCL-GYSLLLMVTCTVYAIKARGVPETFNEAKP 784
           D+    T        ++ C        G     +  L   C +     R  P  +N A+ 
Sbjct: 710 DWHMLPT------EALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARG 763

Query: 785 IGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVIL 844
           + F M    I W++FVP+         ++ ++      +L L     L   ++P+ Y+++
Sbjct: 764 LTFAMLAYFITWVSFVPLLANV-----QVVLRPAVQMGALLLCVLGILAAFHLPRCYLLM 818

Query: 845 FHPEQN 850
             P  N
Sbjct: 819 RQPGLN 824


>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
           sapiens]
          Length = 254

 Score =  200 bits (509), Expect = 4e-51
 Identities = 109/231 (47%), Positives = 146/231 (63%), Gaps = 10/231 (4%)

Query: 637 ITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTS 696
           +TF+ +A+P  AVC  RRL LG   ++ YSALLTKTNRI RIF   +     P FISP S
Sbjct: 1   MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 60

Query: 697 QLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGV-LKCDMSDLSLIGCL 755
           Q+ I  +L S Q++ ++AWL    P +       +   PE+   V L+C+  D S++G L
Sbjct: 61  QVAICLALISGQLLIVVAWLVVEAPGT------GKETAPERREVVTLRCNHRDASMLGSL 114

Query: 756 GYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYI 815
            Y++LL+  CT+YA K R  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+       +
Sbjct: 115 AYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR---V 171

Query: 816 QTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAA 866
           QTTT+ VS+SLS SV LG L+ PK ++ILF P++NV   +       + AA
Sbjct: 172 QTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA 222


>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
          Length = 587

 Score =  122 bits (306), Expect = 1e-27
 Identities = 114/426 (26%), Positives = 182/426 (42%), Gaps = 38/426 (8%)

Query: 440 MLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAET-LR 498
           MLL+ I  V F     T V FN+N D    Y+I  +   NG   +        W+   L 
Sbjct: 166 MLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWD-WNGPKWTFTVLGSSTWSPVQLN 223

Query: 499 LDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF--QVDEFTCE 556
           ++   +QW G  ++VP S+CS  C  G ++ +     CC+ C  C    F  + D + C+
Sbjct: 224 INETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQ 283

Query: 557 ACPGDMRPTPNHTGCRPTPVVRL------SWSSPWAAPPLLLAVLGIVATTTVVATFVRY 610
            C  +         C P  VV L      SW    A   LLL +LG          F  +
Sbjct: 284 PCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLG------TAGLFAWH 337

Query: 611 NNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLT 670
            +TP+VR++G  L +++L  +       +    EP    C  R+    LG T+  S L  
Sbjct: 338 LDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTV 397

Query: 671 KTNRIYRIFEQGKRSVTPPPFISPTSQ-----LVITFSLTSLQVVGMIAWLGARPPHSVI 725
           ++ ++  IF   K S   P F     Q     L +  S ++ Q++  + WL    P    
Sbjct: 398 RSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMIS-SAAQLLICLTWLVVWTPLPAR 453

Query: 726 DYEEQRTVDPEQARGVLKC-DMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKP 784
           +Y+    +       +L+C + + L  I    Y+ LL ++    +   + +PE +NEAK 
Sbjct: 454 EYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKC 507

Query: 785 IGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVIL 844
           + F++    + W+A    FF TA   +  Y+    +   LS S S   G  ++PK YVIL
Sbjct: 508 VTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVIL 562

Query: 845 FHPEQN 850
             P+ N
Sbjct: 563 CRPDLN 568



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 46/174 (26%), Positives = 71/174 (40%), Gaps = 30/174 (17%)

Query: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
           L  L+   W        ++    L G   L GLFP+H+               R+C    
Sbjct: 11  LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68

Query: 62  KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTC--SRDTYALEQALSFV-QALIR 118
            E G H  +AM   ++ +N    LLP + LG +L D C  S + YA  + LS   Q  I 
Sbjct: 69  NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128

Query: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQI 172
            +GD              L  +P   V+AV+G  +++ +   A +L  F +P +
Sbjct: 129 LQGD-------------LLHYSP--TVLAVIGPDSTNRAATTAALLSPFLVPML 167


>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
          Length = 480

 Score =  119 bits (299), Expect = 9e-27
 Identities = 90/312 (28%), Positives = 146/312 (46%), Gaps = 33/312 (10%)

Query: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
           L  L+   W        ++    L G   L GLFP+H+               R+C    
Sbjct: 11  LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68

Query: 62  KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS--RDTYALEQALSFV-QALIR 118
            E G H  +AM   ++ +N    LLP + LG +L D CS   + YA  + LS   Q  I 
Sbjct: 69  NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128

Query: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTA 178
            +GD              L  +P   V+AV+G  +++ +   A +L  F +P ISYA+++
Sbjct: 129 LQGD-------------LLHYSPT--VLAVIGPDSTNRAATTAALLSPFLVPMISYAASS 173

Query: 179 PELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISR 238
             LS   +Y  F R +P D YQ + MV +++  GW ++S + S  +YG+ GV+A ++   
Sbjct: 174 ETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQA-LENQA 232

Query: 239 EAGGVCIAQSIKIPREPKPG-EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANL 297
              G+CIA    +P   + G E  + + R +    A  +++F++    R   E+    NL
Sbjct: 233 TGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNL 292

Query: 298 TGHFLWVGSDSW 309
           TG  +WV S++W
Sbjct: 293 TGK-VWVASEAW 303


>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 51/245 (20%)

Query: 10  PLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVH---ARGAAGRACGQLKKEQGV 66
           PLL+ L P AW    G  R   S   +  L++ GL P+    A+G+ GR           
Sbjct: 30  PLLLPLAPGAWGWARGAPRPPPS---SPPLSIMGLMPLTKEVAKGSIGRGV--------- 77

Query: 67  HRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEV 126
             L A+  A++++  +  L P   L  RL DT   +   L+   +F  A+  G       
Sbjct: 78  --LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDAIKYG------- 124

Query: 127 GVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTR 186
                          P  ++ V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +
Sbjct: 125 ---------------PNHLM-VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKK 168

Query: 187 YDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIA 246
           Y +F R VP D+    A++ +++   W  V TL  +       V+ F ++  +  GV   
Sbjct: 169 YPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYG 221

Query: 247 QSIKI 251
           + I+I
Sbjct: 222 EDIEI 226


>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
           precursor [Homo sapiens]
          Length = 899

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 56/287 (19%), Positives = 116/287 (40%), Gaps = 17/287 (5%)

Query: 591 LLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAE------ 644
           +L+ LGIV     ++  +  ++   ++ S   L+ +   G  L  A  F +  +      
Sbjct: 535 VLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGR 594

Query: 645 -PGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFS 703
                VC AR   LGLG +L Y ++ TK   ++ +F + +        + P         
Sbjct: 595 NQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 654

Query: 704 LTSLQVVGMIAWLGARPPHSVID----YEEQRTVDPEQARGVLKCDMSDLSL-IGCL-GY 757
           L  + V+ +  W    P H  I+     E +  +D      +  C    ++  +G   GY
Sbjct: 655 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 714

Query: 758 SLLLMVTCTVYAIKARGV-PETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQ 816
             LL++     A + + V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 715 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 772

Query: 817 TTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATST 863
               ++++  S+ ++L +L+VPK   ++   E   + +      +ST
Sbjct: 773 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSST 818



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 38/201 (18%)

Query: 41  LGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS 100
           +G LFP+      G+AC             A+  AL+ VN+  ++LP   L  +L+   S
Sbjct: 110 IGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHHDS 156

Query: 101 RDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMV 160
           +      QA  ++  L+                        P +++ + G S  SVS +V
Sbjct: 157 KCDPG--QATKYLYELLYN---------------------DPIKIILMPGCS--SVSTLV 191

Query: 161 ANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLA 220
           A   R++ +  +SY S++P LS+  R+  F R  P  +      V +    GW  ++T+ 
Sbjct: 192 AEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQ 251

Query: 221 SEGNYGESGVEAFVQISREAG 241
                  S ++   +  +EAG
Sbjct: 252 QTTEVFTSTLDDLEERVKEAG 272


>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
           precursor [Homo sapiens]
          Length = 844

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 56/287 (19%), Positives = 116/287 (40%), Gaps = 17/287 (5%)

Query: 591 LLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAE------ 644
           +L+ LGIV     ++  +  ++   ++ S   L+ +   G  L  A  F +  +      
Sbjct: 480 VLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGR 539

Query: 645 -PGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFS 703
                VC AR   LGLG +L Y ++ TK   ++ +F + +        + P         
Sbjct: 540 NQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 599

Query: 704 LTSLQVVGMIAWLGARPPHSVID----YEEQRTVDPEQARGVLKCDMSDLSL-IGCL-GY 757
           L  + V+ +  W    P H  I+     E +  +D      +  C    ++  +G   GY
Sbjct: 600 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 659

Query: 758 SLLLMVTCTVYAIKARGV-PETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQ 816
             LL++     A + + V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 660 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 717

Query: 817 TTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATST 863
               ++++  S+ ++L +L+VPK   ++   E   + +      +ST
Sbjct: 718 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSST 763



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 38/201 (18%)

Query: 41  LGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS 100
           +G LFP+      G+AC             A+  AL+ VN+  ++LP   L  +L+   S
Sbjct: 55  IGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHHDS 101

Query: 101 RDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMV 160
           +      QA  ++  L+                        P +++ + G S  SVS +V
Sbjct: 102 KCDPG--QATKYLYELLYN---------------------DPIKIILMPGCS--SVSTLV 136

Query: 161 ANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLA 220
           A   R++ +  +SY S++P LS+  R+  F R  P  +      V +    GW  ++T+ 
Sbjct: 137 AEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQ 196

Query: 221 SEGNYGESGVEAFVQISREAG 241
                  S ++   +  +EAG
Sbjct: 197 QTTEVFTSTLDDLEERVKEAG 217


>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
           precursor [Homo sapiens]
          Length = 961

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 56/287 (19%), Positives = 116/287 (40%), Gaps = 17/287 (5%)

Query: 591 LLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAE------ 644
           +L+ LGIV     ++  +  ++   ++ S   L+ +   G  L  A  F +  +      
Sbjct: 597 VLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGR 656

Query: 645 -PGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFS 703
                VC AR   LGLG +L Y ++ TK   ++ +F + +        + P         
Sbjct: 657 NQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 716

Query: 704 LTSLQVVGMIAWLGARPPHSVID----YEEQRTVDPEQARGVLKCDMSDLSL-IGCL-GY 757
           L  + V+ +  W    P H  I+     E +  +D      +  C    ++  +G   GY
Sbjct: 717 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 776

Query: 758 SLLLMVTCTVYAIKARGV-PETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQ 816
             LL++     A + + V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 777 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 834

Query: 817 TTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATST 863
               ++++  S+ ++L +L+VPK   ++   E   + +      +ST
Sbjct: 835 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSST 880



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 38/201 (18%)

Query: 41  LGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS 100
           +G LFP+      G+AC             A+  AL+ VN+  ++LP   L  +L+   S
Sbjct: 172 IGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHHDS 218

Query: 101 RDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMV 160
           +      QA  ++  L+                        P +++ + G S  SVS +V
Sbjct: 219 KCDPG--QATKYLYELLYN---------------------DPIKIILMPGCS--SVSTLV 253

Query: 161 ANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLA 220
           A   R++ +  +SY S++P LS+  R+  F R  P  +      V +    GW  ++T+ 
Sbjct: 254 AEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQ 313

Query: 221 SEGNYGESGVEAFVQISREAG 241
                  S ++   +  +EAG
Sbjct: 314 QTTEVFTSTLDDLEERVKEAG 334


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 15/144 (10%)

Query: 167 FAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLAS---EG 223
           + IP +   +     SD + +  F R VPP S+Q+    +++R   WN++  L S   EG
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 224 NYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETP--NARGIIIFAN 281
              +  +E  ++  RE+    + Q         PG    V   LME     AR II+ A+
Sbjct: 174 RAAQKRLETLLE-ERESKAEKVLQF-------DPGT-KNVTALLMEAKELEARVIILSAS 224

Query: 282 EDDIRRVLEAARQANLTGH-FLWV 304
           EDD   V  AA   N+TG  ++W+
Sbjct: 225 EDDAATVYRAAAMLNMTGSGYVWL 248


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 15/144 (10%)

Query: 167 FAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLAS---EG 223
           + IP +   +     SD + +  F R VPP S+Q+    +++R   WN++  L S   EG
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 224 NYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETP--NARGIIIFAN 281
              +  +E  ++  RE+    + Q         PG    V   LME     AR II+ A+
Sbjct: 174 RAAQKRLETLLE-ERESKAEKVLQF-------DPGT-KNVTALLMEAKELEARVIILSAS 224

Query: 282 EDDIRRVLEAARQANLTGH-FLWV 304
           EDD   V  AA   N+TG  ++W+
Sbjct: 225 EDDAATVYRAAAMLNMTGSGYVWL 248


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 15/144 (10%)

Query: 167 FAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLAS---EG 223
           + IP +   +     SD + +  F R VPP S+Q+    +++R   WN++  L S   EG
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 224 NYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETP--NARGIIIFAN 281
              +  +E  ++  RE+    + Q         PG    V   LME     AR II+ A+
Sbjct: 174 RAAQKRLETLLE-ERESKAEKVLQF-------DPGT-KNVTALLMEAKELEARVIILSAS 224

Query: 282 EDDIRRVLEAARQANLTGH-FLWV 304
           EDD   V  AA   N+TG  ++W+
Sbjct: 225 EDDAATVYRAAAMLNMTGSGYVWL 248


>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
          Length = 324

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/110 (30%), Positives = 49/110 (44%), Gaps = 3/110 (2%)

Query: 440 MLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAET-LR 498
           MLL+ I  V F     T V FN+N D    Y+I  +   NG   +        W+   L 
Sbjct: 166 MLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWD-WNGPKWTFTVLGSSTWSPVQLN 223

Query: 499 LDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF 548
           ++   +QW G  ++VP S+CS  C  G ++ +     CC+ C  C    F
Sbjct: 224 INETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTF 273



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 46/174 (26%), Positives = 71/174 (40%), Gaps = 30/174 (17%)

Query: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
           L  L+   W        ++    L G   L GLFP+H+               R+C    
Sbjct: 11  LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68

Query: 62  KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTC--SRDTYALEQALSFV-QALIR 118
            E G H  +AM   ++ +N    LLP + LG +L D C  S + YA  + LS   Q  I 
Sbjct: 69  NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128

Query: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQI 172
            +GD              L  +P   V+AV+G  +++ +   A +L  F +P +
Sbjct: 129 LQGD-------------LLHYSP--TVLAVIGPDSTNRAATTAALLSPFLVPML 167


>gi|7706451 G protein-coupled receptor, family C, group 5, member B
           precursor [Homo sapiens]
          Length = 403

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 57/262 (21%), Positives = 109/262 (41%), Gaps = 36/262 (13%)

Query: 593 AVLGIVATTTVVATFVRYNNTPIVRASGRE----LSYVLLTGIFLIYAITFLMVAEPGAA 648
           AV G  A  T++   +     P ++   ++    L ++ L G   ++ +TF  + +    
Sbjct: 61  AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET 120

Query: 649 VCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLV-ITFSLTSL 707
           +C+ RR   G+   L +S LL++  R+ R+   G    T P       QLV +   L  +
Sbjct: 121 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHG----TGP----AGWQLVGLALCLMLV 172

Query: 708 QVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTV 767
           QV+  + WL      +V+     R   P        C    +  +  L Y ++L+V    
Sbjct: 173 QVIIAVEWLVL----TVL-----RDTRP-------ACAYEPMDFVMALIYDMVLLVVTLG 216

Query: 768 YAIKARGVPETFNEAKPIG----FTMYTTCIIWLAFVPIF-FGTAQSAEKIYIQTTTLTV 822
            A+    +   F   K  G     T + + +IW+A++ ++ FG  +  +       TL +
Sbjct: 217 LALFT--LCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAI 274

Query: 823 SLSLSASVSLGMLYVPKTYVIL 844
           +L+ S  V +    +P+ +  L
Sbjct: 275 TLAASGWVFVIFHAIPEIHCTL 296


>gi|23308585 G protein-coupled receptor 156 [Homo sapiens]
          Length = 814

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 16/180 (8%)

Query: 555 CEACPG-DMRPTPNHTGCRPTPVVRLSWSSPWAA-PPLLLAVL------GIVATTTVVAT 606
           C++ PG ++   P H  C+ T       S   ++  P+LL ++      G++     +A 
Sbjct: 11  CDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAF 70

Query: 607 FVRYNNTPIVRASGRELSYVLLTGIFLIYAITFL------MVAEPGAAVCAARRLFLGLG 660
            +      IV+ S   L+ V L G  L Y+  +L      +V      +   R   L +G
Sbjct: 71  TIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIG 130

Query: 661 TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP 720
           T+L +  +L K+ R+Y++F Q  R       I     L +  +L    V+ ++ W+   P
Sbjct: 131 TSLVFGPILGKSWRLYKVFTQ--RVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDP 188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,882,444
Number of Sequences: 37866
Number of extensions: 1616940
Number of successful extensions: 4456
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 4276
Number of HSP's gapped (non-prelim): 75
length of query: 877
length of database: 18,247,518
effective HSP length: 111
effective length of query: 766
effective length of database: 14,044,392
effective search space: 10758004272
effective search space used: 10758004272
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.