Search of human proteins with 166851846

Search of human proteins with 166851846

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166851846 centaurin, gamma-like family, member 3 [Homo
sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]   1389   0.0  
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1331   0.0  
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1319   0.0  
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1316   0.0  
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1305   0.0  
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1305   0.0  
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1292   0.0  
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat...   969   0.0  
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]               807   0.0  
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]              571   e-163
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]               565   e-161
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]           468   e-132
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]         460   e-129
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,...   345   8e-95
gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]                150   5e-36
gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]                150   5e-36
gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]                150   5e-36
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...   144   4e-34
gi|187608516 centaurin, beta 2 [Homo sapiens]                         131   2e-30
gi|7661880 centaurin beta1 [Homo sapiens]                             129   7e-30
gi|46094081 development and differentiation enhancing factor 1 [...   127   3e-29
gi|206725422 G protein-coupled receptor kinase interacting ArfGA...   127   3e-29
gi|206725420 G protein-coupled receptor kinase interacting ArfGA...   127   3e-29
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP...   127   3e-29
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP...   127   3e-29
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP...   127   3e-29
gi|206725415 G protein-coupled receptor kinase interacting ArfGA...   127   3e-29
gi|146231998 G protein-coupled receptor kinase interactor 1 isof...   124   3e-28
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo...   124   3e-28
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai...   112   1e-24

>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
          Length = 686

 Score = 1389 bits (3596), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS
Sbjct: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 5 [Homo sapiens]
          Length = 686

 Score = 1331 bits (3444), Expect = 0.0
 Identities = 660/686 (96%), Positives = 668/686 (97%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMHH+RD+EMPEALEF+LSANPE+STIFQRNSQT+ALEFNPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS  RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 9 [Homo sapiens]
          Length = 684

 Score = 1319 bits (3413), Expect = 0.0
 Identities = 657/686 (95%), Positives = 664/686 (96%), Gaps = 2/686 (0%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMH VRDREMPEALEFNLSANPE+STIFQRNSQT+ALEFN SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS  RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIHRS G  LSRVRSLELDDWPVELRKVMSSI N+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 10 [Homo sapiens]
          Length = 684

 Score = 1316 bits (3406), Expect = 0.0
 Identities = 656/686 (95%), Positives = 663/686 (96%), Gaps = 2/686 (0%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMH VRDREMPEALEFNLSANPE+STIFQRNSQT+ALEFN SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS  RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCK SMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIHRS G  LSRVRSLELDDWPVELRKVMSSI N+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 4 [Homo sapiens]
          Length = 663

 Score = 1305 bits (3378), Expect = 0.0
 Identities = 651/686 (94%), Positives = 656/686 (95%), Gaps = 23/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMHHVRDREMPEALEFN                       PSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS VRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPIS+SKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDKCV 663


>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 8 [Homo sapiens]
          Length = 663

 Score = 1305 bits (3376), Expect = 0.0
 Identities = 652/686 (95%), Positives = 654/686 (95%), Gaps = 23/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMHHVRDREMPEALEFN                       PSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS VRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIH SLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLL ATADEDL
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDECV 663


>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 7 [Homo sapiens]
          Length = 663

 Score = 1292 bits (3343), Expect = 0.0
 Identities = 645/686 (94%), Positives = 650/686 (94%), Gaps = 23/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
           DLHMHHVRDREMPEALEFN                       PSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS V FSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVHFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMK IHKKEIDLQTSTIKVPGKWPSLAT ACTPISSSKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           +GLSKDMDTGLGDSICFSPSISSTT PKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 DGLSKDMDTGLGDSICFSPSISSTTIPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457

Query: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
           DCETQNPKWASLNLGVLMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
           NSIWEGSSQG+TKP+EKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL
Sbjct: 518 NSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577

Query: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDECV 663


>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
           protein 11 [Homo sapiens]
          Length = 550

 Score =  969 bits (2504), Expect = 0.0
 Identities = 490/550 (89%), Positives = 503/550 (91%), Gaps = 25/550 (4%)

Query: 162 MTIISVTLEIPHHITQRDADRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 221
           MTIISVTLEI HHIT+RDADR+L+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 1   MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60

Query: 222 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 281
           PSTSQED  FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 61  PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120

Query: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 341
           IPIKQGMLLKRSGKWLKTWKKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180

Query: 342 GKWPSLATSACTPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 392
           GKWPSLATSAC PISSSKSNGLSKDM         D GLGDSICFSPSISSTTSPKLN P
Sbjct: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240

Query: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
           PSPHANKKKHLKKKSTNN                FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300

Query: 437 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 496
           AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360

Query: 497 LMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSE 556
           LMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLANSIWEGSSQGQTKPS 
Sbjct: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420

Query: 557 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVN 616
           +STREEKERWIRSKYE KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGS EEVN
Sbjct: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480

Query: 617 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 676
           ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540

Query: 677 LQYGCPDECV 686
           LQYGCPDECV
Sbjct: 541 LQYGCPDECV 550


>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
          Length = 804

 Score =  807 bits (2085), Expect = 0.0
 Identities = 411/532 (77%), Positives = 452/532 (84%), Gaps = 32/532 (6%)

Query: 185 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           S+P+   HS      VS VHI +  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
           TPV K+S R SNLFTS KGSDPDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 300 WKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 359
           WKKKYVTLC NG+LTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSAC PISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 360 SNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNN 410
           +NGLSKDM         DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+N
Sbjct: 425 TNGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSN 484

Query: 411 F------------------MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESS 452
           F                  +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESS
Sbjct: 485 FKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESS 544

Query: 453 KSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPH 512
           K+KS+LTSQSEAMALQSI+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LG H
Sbjct: 545 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTH 604

Query: 513 LSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYE 572
           LSRVRSL+LDDWPVEL KVMSSI N+LANS+WE SSQG+TKPS  STREEKERWIR+KYE
Sbjct: 605 LSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYE 664

Query: 573 EKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLAC 632
           +KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGS +EVNETCGEGDG TALHLAC
Sbjct: 665 QKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLAC 724

Query: 633 RKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
           RKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 725 RKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 776


>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
          Length = 911

 Score =  571 bits (1472), Expect = e-163
 Identities = 306/582 (52%), Positives = 388/582 (66%), Gaps = 82/582 (14%)

Query: 185 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 239
           S+P+   HS     ++  VHI +  NGGGS  ++YSSS+PSTPS SQ + +      ++T
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360

Query: 240 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
           PTP+ K+S R SN+FTS KG+D D+E+KA E   D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420

Query: 299 TWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 354
            WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL  +T+KVPGK    AT A  P    
Sbjct: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480

Query: 355 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 383
               +S  +SN                S   +  L  S    P          S+SS   
Sbjct: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540

Query: 384 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
                                  ++SPKL+PPPSPH+N+KKH +KKST            
Sbjct: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600

Query: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 462
                   F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660

Query: 463 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELD 522
            A+A+Q+++ +RGN+ C+DC+  NP WASLNLG LMCIECSGIHR LG HLSRVRSL+LD
Sbjct: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720

Query: 523 DWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 582
           DWP EL  VM+++ N LANS+WEG+  G +KP   + REEKERWIR+KYE+KLFLAPLP 
Sbjct: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780

Query: 583 TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQL 642
           +++ LGQQLLRA  ++DL+  ++LLAHGS EEVNET G+GDG TALHL+    NVV  QL
Sbjct: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840

Query: 643 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
           LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882


>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
          Length = 857

 Score =  565 bits (1456), Expect = e-161
 Identities = 280/335 (83%), Positives = 301/335 (89%), Gaps = 18/335 (5%)

Query: 368 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 411
           DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF                
Sbjct: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554

Query: 412 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQS 469
             +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQS
Sbjct: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614

Query: 470 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELR 529
           I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LG HLSRVRSL+LDDWPVEL 
Sbjct: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674

Query: 530 KVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 589
           KVMSSI N+LANS+WE SSQG+TKPS  STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734

Query: 590 QLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 649
            LLRATADEDL+TAILLLAHGS +EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794

Query: 650 VMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
           V ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829



 Score =  257 bits (656), Expect = 3e-68
 Identities = 136/207 (65%), Positives = 159/207 (76%), Gaps = 10/207 (4%)

Query: 185 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           S+P+   HS      VS VHI +  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
           TPV K+S R SNLFTS KGSDPDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 300 WKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 359
           WKKKYVTLC NG+LTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSAC PISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 360 SNGLSKDMDTGLGDSICFSPSISSTTS 386
           +NGLSKDM      S+  SP+  + TS
Sbjct: 425 TNGLSKDM-----SSLHISPNSGNVTS 446


>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
          Length = 836

 Score =  468 bits (1205), Expect = e-132
 Identities = 265/557 (47%), Positives = 346/557 (62%), Gaps = 63/557 (11%)

Query: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
           S+P    HS A + V    + + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302

Query: 243 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
           + + + R ++LF + +GSD   E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360

Query: 302 KKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 361
           KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  S+  N
Sbjct: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418

Query: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
           GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478

Query: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
                    PPPSP   K++  K              ++    F+IVS+TGQTWHFEA +
Sbjct: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538

Query: 428 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 487
           +EERDAWVQAI+SQILASLQ CESSK K +  SQSEA+A+Q+I+N +GN+ CVDC   NP
Sbjct: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598

Query: 488 KWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGS 547
            WASLNLG L+CIECSGIHR+LG HLSRVRSL+LDDWP EL  V+++I ND AN +WE  
Sbjct: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658

Query: 548 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLL 607
           ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  LG+QL  A   +D+ T +LLL
Sbjct: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718

Query: 608 AHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 667
           AH     ++ +  +    + LHLA    +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778

Query: 668 SSQECINVLLQYGCPDE 684
            SQ C ++LLQ+GCP E
Sbjct: 779 GSQLCADILLQHGCPGE 795


>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
          Length = 1192

 Score =  460 bits (1184), Expect = e-129
 Identities = 265/577 (45%), Positives = 346/577 (59%), Gaps = 83/577 (14%)

Query: 185  SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
            S+P    HS A + V    + + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 581  SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638

Query: 243  VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
            + + + R ++LF + +GSD   E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 639  LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696

Query: 302  KKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 361
            KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  S+  N
Sbjct: 697  KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754

Query: 362  GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
            GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 755  GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814

Query: 388  ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
                     PPPSP   K++  K  + +                                
Sbjct: 815  GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874

Query: 411  ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 467
               F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K +  SQSEA+A+
Sbjct: 875  NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934

Query: 468  QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVE 527
            Q+I+N +GN+ CVDC   NP WASLNLG L+CIECSGIHR+LG HLSRVRSL+LDDWP E
Sbjct: 935  QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994

Query: 528  LRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 587
            L  V+++I ND AN +WE  ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  L
Sbjct: 995  LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054

Query: 588  GQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647
            G+QL  A   +D+ T +LLLAH     ++ +  +    + LHLA    +VV+ QLL+WYG
Sbjct: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114

Query: 648  VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
             DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151


>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
           member 1 [Homo sapiens]
          Length = 284

 Score =  345 bits (885), Expect = 8e-95
 Identities = 170/173 (98%), Positives = 171/173 (98%)

Query: 514 SRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 573
           SRVRSLELDDWPVELRKVMSSI NDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 171

Query: 574 KLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACR 633
           KLFLAPLPCT+LSLGQQLLRATADEDLQTAILLLAHGS EEVNETCGEGDGCTALHLACR
Sbjct: 172 KLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 231

Query: 634 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 686
           KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
Sbjct: 232 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 284



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 17/18 (94%), Positives = 18/18 (100%)

Query: 178 RDADRTLSIPDEQLHSFA 195
           RDADR+LSIPDEQLHSFA
Sbjct: 94  RDADRSLSIPDEQLHSFA 111


>gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  150 bits (378), Expect = 5e-36
 Identities = 96/200 (48%), Positives = 114/200 (57%), Gaps = 28/200 (14%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESE YEA A D +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQ 118
            LHMHH+ +REMPE   LE N S +P++STIF R SQT+                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VS   F+QQYS CSTIFLDDS A Q +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRTLSIPDEQLHSFAV 196
           +RDA R+L I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  150 bits (378), Expect = 5e-36
 Identities = 96/200 (48%), Positives = 114/200 (57%), Gaps = 28/200 (14%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESE YEA A D +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQ 118
            LHMHH+ +REMPE   LE N S +P++STIF R SQT+                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VS   F+QQYS CSTIFLDDS A Q +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRTLSIPDEQLHSFAV 196
           +RDA R+L I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  150 bits (378), Expect = 5e-36
 Identities = 96/200 (48%), Positives = 114/200 (57%), Gaps = 28/200 (14%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESE YEA A D +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQ 118
            LHMHH+ +REMPE   LE N S +P++STIF R SQT+                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VS   F+QQYS CSTIFLDDS A Q +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRTLSIPDEQLHSFAV 196
           +RDA R+L I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score =  144 bits (362), Expect = 4e-34
 Identities = 81/192 (42%), Positives = 114/192 (59%), Gaps = 22/192 (11%)

Query: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 459
           F ++S T ++   +A + + R AWVQA+Q+ I ++ +    SC S       S S S + 
Sbjct: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390

Query: 460 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGP 511
           S ++           LQ +Q++ GN+ C DC   +P+WAS+NLGVL+CIECSGIHRSLG 
Sbjct: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450

Query: 512 HLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 569
           H S+VRSL LD W  EL K+M  + N   N I+E   +  G  KP+  S+R++KE WI+ 
Sbjct: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510

Query: 570 KYEEKLFLAPLP 581
           KY EK FL   P
Sbjct: 511 KYVEKKFLRKAP 522



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)

Query: 584 ELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLL 643
           EL  G    RA    DL      LAHG+  EVN    E +G T L  A   G++++ + L
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722

Query: 644 IWYGVDVMARDAHGNTALTYA 664
           +  G DV  RD+ G   L +A
Sbjct: 723 LQNGADVNQRDSRGRAPLHHA 743


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score =  131 bits (330), Expect = 2e-30
 Identities = 76/186 (40%), Positives = 111/186 (59%), Gaps = 21/186 (11%)

Query: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 461
           F +VS T ++   +A + + R AW++A+Q+ I  + +           +SS S   L S 
Sbjct: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388

Query: 462 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHL 513
           +E+         ALQ +Q + GNA C DC   +P+WAS+NLG+ +CIECSGIHRSLG H 
Sbjct: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448

Query: 514 SRVRSLELDDWPVELRKVMSSIVNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 571
           S+VRSL LD W  EL K+M  + ND+ N ++E +    G  KP +   R+EKE +IR+KY
Sbjct: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507

Query: 572 EEKLFL 577
            E+ F+
Sbjct: 508 VERKFV 513



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 41/143 (28%), Positives = 62/143 (43%), Gaps = 15/143 (10%)

Query: 527 ELRKVMSSIVNDLANSIWEGSSQG-QTKPSEKSTRE----EKERWIRSKYEEKLFLAPLP 581
           ++R    S V    + I + S  G ++ PS  S       E ER   S + +   L P  
Sbjct: 549 QVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNP-- 606

Query: 582 CTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQ 641
                 G QL RA+ +++L      LAHG+  +VN    E +  T L  A   G++V  +
Sbjct: 607 ------GLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVTCE 658

Query: 642 LLIWYGVDVMARDAHGNTALTYA 664
            L+  G +V  RD  G   L +A
Sbjct: 659 FLLQNGANVNQRDVQGRGPLHHA 681


>gi|7661880 centaurin beta1 [Homo sapiens]
          Length = 740

 Score =  129 bits (325), Expect = 7e-30
 Identities = 99/319 (31%), Positives = 135/319 (42%), Gaps = 70/319 (21%)

Query: 414 VSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSK-------------SQLTS 460
           V +T ++   +A +      WV A+QS I ++        S              S  T 
Sbjct: 331 VVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATL 390

Query: 461 QSEAMA-----------LQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSL 509
            S  MA           +  +Q++ GNA C DC    P+WAS+NLGV +CI+CSGIHRSL
Sbjct: 391 GSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSL 450

Query: 510 GPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQT--KPSEKSTREEKERWI 567
           G H S+VRSL LD W  EL K+M  + N + N I+E   +     KP    +R+EKE WI
Sbjct: 451 GVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWI 510

Query: 568 RSKYEEKLFLAPLP-----------------------------------------CTELS 586
            +KY EK FL  LP                                            L 
Sbjct: 511 HAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLH 570

Query: 587 LGQQLLRATA-DEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIW 645
            G  L RA+     L T    LAHG+  +VN   G  D  T L  A    +++  + L+ 
Sbjct: 571 PGALLFRASGHPPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAANSLLACEFLLQ 628

Query: 646 YGVDVMARDAHGNTALTYA 664
            G +V   D+ G   L +A
Sbjct: 629 NGANVNQADSAGRGPLHHA 647



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 4/86 (4%)

Query: 591 LLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDV 650
           L++ATA   L     LL +G+   VN+    G G   LH A   G+  LA L +  G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGA--NVNQADSAGRG--PLHHATILGHTGLACLFLKRGADL 666

Query: 651 MARDAHGNTALTYARQASSQECINVL 676
            ARD+ G   LT A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692


>gi|46094081 development and differentiation enhancing factor 1
           [Homo sapiens]
          Length = 1129

 Score =  127 bits (320), Expect = 3e-29
 Identities = 91/292 (31%), Positives = 142/292 (48%), Gaps = 18/292 (6%)

Query: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 451
           P+A  KK     S N         +T+HF+A   ++  AW+  +   + + L      E 
Sbjct: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427

Query: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGP 511
           S  ++ L   ++A+ ++ +Q + GN  C DC +  P W S NLG+L CIECSGIHR +G 
Sbjct: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486

Query: 512 HLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 570
           H+SR++SLELD        +  ++ N+  N I E +    + KP+  S    ++ +I +K
Sbjct: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546

Query: 571 YEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHG-SCEEVNETCGEGDGCTALH 629
           Y +  F      T  +   +LL A    DL   I + A G    E     G+  G TALH
Sbjct: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALH 606

Query: 630 LACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           LA R   + ++ L   L+    ++  + A GNT L Y    S  EC+ +LL+
Sbjct: 607 LAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658


>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 5 [Homo sapiens]
          Length = 729

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 6 [Homo sapiens]
          Length = 681

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 3 [Homo sapiens]
          Length = 679

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 1 [Homo sapiens]
          Length = 759

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 2 [Homo sapiens]
          Length = 631

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 4 [Homo sapiens]
          Length = 471

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178

Query: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
           1 [Homo sapiens]
          Length = 770

 Score =  124 bits (311), Expect = 3e-28
 Identities = 76/214 (35%), Positives = 115/214 (53%), Gaps = 17/214 (7%)

Query: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVND 538
           C DC   +P WAS++ GVL+C EC  +HRSLG H+S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 539 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 584
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 585 LSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
             L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGTTPLHVAAKAGQTLQAELLV 187

Query: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            YG D  + D +G T + YARQA   E    L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221


>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
           2 [Homo sapiens]
          Length = 761

 Score =  124 bits (311), Expect = 3e-28
 Identities = 76/214 (35%), Positives = 115/214 (53%), Gaps = 17/214 (7%)

Query: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVND 538
           C DC   +P WAS++ GVL+C EC  +HRSLG H+S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 539 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 584
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 585 LSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
             L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGTTPLHVAAKAGQTLQAELLV 187

Query: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            YG D  + D +G T + YARQA   E    L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221


>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
           isoform b [Homo sapiens]
          Length = 961

 Score =  112 bits (279), Expect = 1e-24
 Identities = 76/270 (28%), Positives = 126/270 (46%), Gaps = 10/270 (3%)

Query: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSEAMALQSIQNMRG 475
           +T+HF+A   +E   W+  +Q+    +L +    + +  ++ +  +     +  +Q M G
Sbjct: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432

Query: 476 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSI 535
           N  C DC   +P W S NLG+L CIECSGIHR LG H SR++SL LD        +  +I
Sbjct: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492

Query: 536 VNDLANSIWEG--SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLR 593
            N   N I E    ++   KP+  S    ++ +I +KY E+ +         +    L  
Sbjct: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552

Query: 594 ATADEDLQTAILLLAHG--SCEEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 648
           A    D+   +   A G    E++    G     TALHLA R   + ++ +   L+    
Sbjct: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612

Query: 649 DVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++  +   G+TAL Y     + EC+ +LL+
Sbjct: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.127    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,145,847
Number of Sequences: 37866
Number of extensions: 1244425
Number of successful extensions: 5846
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 4304
Number of HSP's gapped (non-prelim): 1433
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.