Guide to the Human Genome
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Search of human proteins with 166795264

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166795264 AE binding protein 2 isoform b [Homo sapiens]
         (517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166795264 AE binding protein 2 isoform b [Homo sapiens]           1040   0.0  
gi|166795262 AE binding protein 2 isoform a [Homo sapiens]           1013   0.0  
gi|4885279 GLI family zinc finger 1 isoform 1 [Homo sapiens]           81   3e-15
gi|229892345 GLI family zinc finger 1 isoform 2 [Homo sapiens]         80   4e-15
gi|109637784 GLIS family zinc finger 3 isoform a [Homo sapiens]        76   8e-14
gi|109637782 GLIS family zinc finger 3 isoform b [Homo sapiens]        76   8e-14
gi|166706915 GLIS family zinc finger 1 [Homo sapiens]                  73   7e-13
gi|22748877 basic helix-loop-helix domain containing, class B, 5...    72   1e-12
gi|195972866 keratin 10 [Homo sapiens]                                 72   2e-12
gi|51173735 ras responsive element binding protein 1 isoform 2 [...    71   3e-12
gi|51173737 ras responsive element binding protein 1 isoform 1 [...    71   3e-12
gi|86991432 GLI-Kruppel family member GLI2 [Homo sapiens]              70   6e-12
gi|119393899 GLI-Kruppel family member GLI3 [Homo sapiens]             70   6e-12
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    69   8e-12
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         69   8e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    65   1e-10
gi|55956899 keratin 9 [Homo sapiens]                                   65   2e-10
gi|109255251 loricrin [Homo sapiens]                                   65   2e-10
gi|39812496 Sp8 transcription factor isoform 1 [Homo sapiens]          64   3e-10
gi|39812501 Sp8 transcription factor isoform 2 [Homo sapiens]          64   3e-10
gi|110431364 GLIS family zinc finger 2 [Homo sapiens]                  64   3e-10
gi|170650685 zinc finger and BTB domain containing 37 isoform a ...    62   1e-09
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma...    62   2e-09
gi|27894378 chloride intracellular channel 6 [Homo sapiens]            61   3e-09
gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein ...    60   5e-09
gi|118766337 zinc finger protein of the cerebellum 5 [Homo sapiens]    60   5e-09
gi|22547197 zinc finger protein of the cerebellum 2 [Homo sapiens]     59   8e-09
gi|186928827 dermokine isoform 5 precursor [Homo sapiens]              59   8e-09
gi|22547201 zinc finger protein of the cerebellum 4 [Homo sapiens]     59   8e-09
gi|167466187 integrin-binding sialoprotein precursor [Homo sapiens]    59   1e-08

>gi|166795264 AE binding protein 2 isoform b [Homo sapiens]
          Length = 517

 Score = 1040 bits (2688), Expect = 0.0
 Identities = 517/517 (100%), Positives = 517/517 (100%)

Query: 1   MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN 60
           MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN
Sbjct: 1   MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN 60

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120
           GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES
Sbjct: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120

Query: 121 SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180
           SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV
Sbjct: 121 SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180

Query: 181 VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240
           VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR
Sbjct: 181 VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240

Query: 241 STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK 300
           STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK
Sbjct: 241 STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK 300

Query: 301 GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360
           GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK
Sbjct: 301 GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360

Query: 361 VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE 420
           VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE
Sbjct: 361 VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE 420

Query: 421 SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL 480
           SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL
Sbjct: 421 SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL 480

Query: 481 PKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 517
           PKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ
Sbjct: 481 PKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 517


>gi|166795262 AE binding protein 2 isoform a [Homo sapiens]
          Length = 503

 Score = 1013 bits (2620), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN 60
           MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN
Sbjct: 1   MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN 60

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120
           GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES
Sbjct: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120

Query: 121 SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180
           SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV
Sbjct: 121 SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180

Query: 181 VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240
           VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR
Sbjct: 181 VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240

Query: 241 STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK 300
           STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK
Sbjct: 241 STPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWK 300

Query: 301 GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360
           GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK
Sbjct: 301 GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360

Query: 361 VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE 420
           VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE
Sbjct: 361 VSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIE 420

Query: 421 SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL 480
           SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL
Sbjct: 421 SLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKL 480

Query: 481 PKDTALLLDPNIYRTMPQKRLKR 503
           PKDTALLLDPNIYRTMPQKRLKR
Sbjct: 481 PKDTALLLDPNIYRTMPQKRLKR 503


>gi|4885279 GLI family zinc finger 1 isoform 1 [Homo sapiens]
          Length = 1106

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 86/331 (25%), Positives = 129/331 (38%), Gaps = 39/331 (11%)

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
           +R  SPG +      G     L  P     +Q     G S S  V   G      GG   
Sbjct: 112 SRCTSPGGSYGHLSIGTMSPSLGFP-----AQMNHQKGPSPSFGVQPCGPHDSARGGMIP 166

Query: 197 SATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTP--AMMNGQGSTTS 254
              S G   + ++ S+ + L     E+ +     D+ S  S+G   P   M++G+     
Sbjct: 167 HPQSRGPFPTCQLKSELDMLVGKCREEPLEG---DMSSPNSTGIQDPLLGMLDGREDLER 223

Query: 255 SSKN-----IAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPS 309
             K         +C WD C   F+S   L  HI S H+ G+R   FVC W GC     P 
Sbjct: 224 EEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKE-FVCHWGGCSRELRPF 282

Query: 310 TSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKE 369
            +Q  L  HM  H+G+KP KC   GC  S++    L  H+ +H  ++           + 
Sbjct: 283 KAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEK-------PYMCEH 335

Query: 370 ESPSKAGMNKRRKLKNKRR-RSLPRPH---------DFFDAQTLDAIRHRAICFNLSAHI 419
           E  SKA  N   + K++ R  S  +P+          + D  +L   +H        AH+
Sbjct: 336 EGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLR--KHVKTVHGPDAHV 393

Query: 420 ESLGKGHSVVFH----STVIAKRKEDSGKIK 446
               +G   +      STV  KR+ + G I+
Sbjct: 394 TKRHRGDGPLPRAPSISTVEPKREREGGPIR 424


>gi|229892345 GLI family zinc finger 1 isoform 2 [Homo sapiens]
          Length = 978

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 78/294 (26%), Positives = 118/294 (40%), Gaps = 34/294 (11%)

Query: 174 GSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVD 233
           G S S  V   G      GG      S G   + ++ S+ + L     E+ +     D+ 
Sbjct: 16  GPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEG---DMS 72

Query: 234 STISSGRSTP--AMMNGQGSTTSSSKN-----IAYNCCWDQCQACFNSSPDLADHIRSIH 286
           S  S+G   P   M++G+       K         +C WD C   F+S   L  HI S H
Sbjct: 73  SPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEH 132

Query: 287 VDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLA 346
           + G+R   FVC W GC     P  +Q  L  HM  H+G+KP KC   GC  S++    L 
Sbjct: 133 IHGERKE-FVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLK 191

Query: 347 RHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRR-RSLPRPH---------D 396
            H+ +H  ++           + E  SKA  N   + K++ R  S  +P+          
Sbjct: 192 THLRSHTGEK-------PYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKR 244

Query: 397 FFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFH----STVIAKRKEDSGKIK 446
           + D  +L   +H        AH+    +G   +      STV  KR+ + G I+
Sbjct: 245 YTDPSSLR--KHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIR 296


>gi|109637784 GLIS family zinc finger 3 isoform a [Homo sapiens]
          Length = 930

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 1/96 (1%)

Query: 262 NCC-WDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHML 320
           +CC W  C A ++   +L  HI  +H+D ++G  F C W GC     P  ++  L  HM 
Sbjct: 500 HCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMR 559

Query: 321 THSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
            HSG+KP KC   GC  +F+    L  H+ +H  ++
Sbjct: 560 VHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEK 595


>gi|109637782 GLIS family zinc finger 3 isoform b [Homo sapiens]
          Length = 775

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 1/96 (1%)

Query: 262 NCC-WDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHML 320
           +CC W  C A ++   +L  HI  +H+D ++G  F C W GC     P  ++  L  HM 
Sbjct: 345 HCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMR 404

Query: 321 THSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
            HSG+KP KC   GC  +F+    L  H+ +H  ++
Sbjct: 405 VHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEK 440


>gi|166706915 GLIS family zinc finger 1 [Homo sapiens]
          Length = 620

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 32/94 (34%), Positives = 48/94 (51%)

Query: 263 CCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTH 322
           C W  C A +    +L  HI   H+D ++G  F C W GC     P  ++  L  HM  H
Sbjct: 197 CRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVH 256

Query: 323 SGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           SG+KP KC+  GC+ +F+    L  H+ +H  ++
Sbjct: 257 SGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEK 290



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 29/110 (26%), Positives = 54/110 (49%), Gaps = 9/110 (8%)

Query: 263 CCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTH 322
           C ++ C   F+   +L  H+RS H  G++   ++C   GC+   + S+ ++   +H  TH
Sbjct: 264 CMFEGCSKAFSRLENLKIHLRS-HT-GEKP--YLCQHPGCQKAFSNSSDRA---KHQRTH 316

Query: 323 SGDKPFKCVVGGCNASFASQGGLARHVPTHFS--QQNSSKVSSQPKAKEE 370
              KP+ C + GC+  +     L +HV  H +  QQ   K+ + P  + +
Sbjct: 317 LDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPDTEAD 366


>gi|22748877 basic helix-loop-helix domain containing, class B, 5
           [Homo sapiens]
          Length = 381

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 67/207 (32%), Positives = 83/207 (40%), Gaps = 32/207 (15%)

Query: 21  PPGSPGSAARGRAEPPEEEEEEEEEE-----EEAEAEAVAALLL-----NGGSGGGGGGG 70
           PPG   S A     PP E             E A+ E    LL       GGS G GGGG
Sbjct: 39  PPGMDLSLA----PPPRERPASSSSSPLGCFEPADPEGAGLLLPPPGGGGGGSAGSGGGG 94

Query: 71  GGGVGG-----GEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAES- 124
           GGGVG      G A    +PS  S   AG     +  +       + S GGE+    +S 
Sbjct: 95  GGGVGVPGLLVGSAGVGGDPSLSSLP-AGAALCLKYGESASRGSVAESSGGEQSPDDDSD 153

Query: 125 ----LVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKG---PRGSQGGGGGGSSS 177
               LV  +G +        SPGA    +   +G        G   P G  GGGGGG SS
Sbjct: 154 GRCELVLRAGVADP----RASPGAGGGGAKAAEGCSNAHLHGGASVPPGGLGGGGGGGSS 209

Query: 178 SSVVSSGGDEGYGTGGGGSSATSGGRR 204
           S     GG  G G+GG  SS++S  ++
Sbjct: 210 SGSSGGGGGSGSGSGGSSSSSSSSSKK 236



 Score = 32.7 bits (73), Expect = 0.82
 Identities = 19/41 (46%), Positives = 22/41 (53%), Gaps = 7/41 (17%)

Query: 59  LNGGSGGG------GGGGGGGVG-GGEAETMSEPSPESASQ 92
           L GG GGG      GGGGG G G GG + + S  S +S  Q
Sbjct: 200 LGGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSKEQ 240



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 15/41 (36%), Positives = 22/41 (53%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEE 101
           GG GGGG   G   GGG + + S  S  S+S + +   E++
Sbjct: 201 GGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSKEQK 241



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 31/127 (24%), Positives = 45/127 (35%), Gaps = 31/127 (24%)

Query: 17  LSPLPPGSP------GSAARGRAEPPEEEEEEEEEEEEAEAE-----AVAALLLNGGSGG 65
           LS LP G+        SA+RG        E+  +++ +   E      VA    + G+GG
Sbjct: 116 LSSLPAGAALCLKYGESASRGSVAESSGGEQSPDDDSDGRCELVLRAGVADPRASPGAGG 175

Query: 66  GG--------------------GGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEE 105
           GG                    GG GGG GGG +   S     S S +G          +
Sbjct: 176 GGAKAAEGCSNAHLHGGASVPPGGLGGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSK 235

Query: 106 EEDESSS 112
           +  E  +
Sbjct: 236 KSKEQKA 242


>gi|195972866 keratin 10 [Homo sapiens]
          Length = 584

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 61/166 (36%), Positives = 66/166 (39%), Gaps = 27/166 (16%)

Query: 48  EAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEE 107
           E E +   +LL   GS GGGG GGG  GGG     S          G             
Sbjct: 443 ENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGG------------- 489

Query: 108 DESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGS 167
               SSGGG          GSSGG SS        G  SSS G G    G     G  G 
Sbjct: 490 GHGGSSGGGYGG-------GSSGGGSSGG----GYGGGSSSGGHGGSSSG-GYGGGSSGG 537

Query: 168 QGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDG 213
            GGG GG SS    SSGG  G G+  GG  ++S G  G  E SS G
Sbjct: 538 GGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVG--ESSSKG 581



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/165 (29%), Positives = 59/165 (35%), Gaps = 19/165 (11%)

Query: 63  SGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSA 122
           S  GGGGGGGG GGG   +    S    S  G                 SSGG    S +
Sbjct: 14  SRSGGGGGGGGCGGGGGVSSLRISSSKGSLGG---------------GFSSGGFSGGSFS 58

Query: 123 ESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVS 182
               GSSGG     +     G      G   G  G     G  G   GGG     S    
Sbjct: 59  R---GSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGG 115

Query: 183 SGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISS 227
           S G  G+G GGG      GG  G   + S  E ++  +  D ++S
Sbjct: 116 SFGGGGFG-GGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLAS 159



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 33/96 (34%), Positives = 37/96 (38%), Gaps = 9/96 (9%)

Query: 110 SSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQG 169
           SS SGGG          G  GG SS     L   ++  S G G    G       RGS G
Sbjct: 13  SSRSGGGGGGGGC----GGGGGVSS-----LRISSSKGSLGGGFSSGGFSGGSFSRGSSG 63

Query: 170 GGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRG 205
           GG  G SS      GG  G    G   S++ GG  G
Sbjct: 64  GGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYG 99



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 27/68 (39%), Positives = 29/68 (42%), Gaps = 11/68 (16%)

Query: 139 SLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSA 198
           S S   +SS SG G G  G            GGGGG SS  + SS G  G G   GG S 
Sbjct: 6   SSSKHYSSSRSGGGGGGGGC-----------GGGGGVSSLRISSSKGSLGGGFSSGGFSG 54

Query: 199 TSGGRRGS 206
            S  R  S
Sbjct: 55  GSFSRGSS 62



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 14/17 (82%), Positives = 14/17 (82%)

Query: 61  GGSGGGGGGGGGGVGGG 77
           GGS GGGG GGGG GGG
Sbjct: 114 GGSFGGGGFGGGGFGGG 130



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 19/47 (40%), Positives = 23/47 (48%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEE 107
           GG GGG GG GG + G E  TM   +   AS   +    EE + E E
Sbjct: 129 GGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELE 175



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 33/89 (37%), Positives = 36/89 (40%), Gaps = 7/89 (7%)

Query: 132 SSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGG---GG--GSSSSSVVSSGGD 186
           SS   + S S G        G G          +GS GGG   GG  G S S   S GG 
Sbjct: 7   SSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGC 66

Query: 187 EGYGTGG-GGSSATSGGR-RGSLEMSSDG 213
            G  +GG GG     GG  RGS   SS G
Sbjct: 67  FGGSSGGYGGLGGFGGGSFRGSYGSSSFG 95



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 13/17 (76%), Positives = 13/17 (76%)

Query: 61  GGSGGGGGGGGGGVGGG 77
           GG G GGGG GGG GGG
Sbjct: 118 GGGGFGGGGFGGGFGGG 134



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 13/17 (76%), Positives = 13/17 (76%)

Query: 61  GGSGGGGGGGGGGVGGG 77
           GGS GGG  GGGG GGG
Sbjct: 109 GGSFGGGSFGGGGFGGG 125


>gi|51173735 ras responsive element binding protein 1 isoform 2
           [Homo sapiens]
          Length = 1687

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 53/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)

Query: 217 SRMDSEDSISSTIMDVDSTISSGRSTPAMMN----------GQGSTTSSSKNIAYNCCWD 266
           S + S +++ S +M V     +G S   + +          G+ +  +  +  +YNC   
Sbjct: 12  SDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETKEEKSSYNC--P 69

Query: 267 QCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDK 326
            C+    +   L  HIR  + D   GG        C +     +S S L RHML HSG++
Sbjct: 70  LCEKICTTQHQLTMHIRQHNTD--TGGAD----HSCSICGKSLSSASSLDRHMLVHSGER 123

Query: 327 PFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNK 386
           P+KC V  C  SF + G + RH+  H    NS+  ++ P     SP      KRR+L +K
Sbjct: 124 PYKCTV--CGQSFTTNGNMHRHMKIHEKDPNSATATAPP-----SPL-----KRRRLSSK 171

Query: 387 RRRS 390
           R+ S
Sbjct: 172 RKLS 175



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 73/319 (22%), Positives = 110/319 (34%), Gaps = 38/319 (11%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDE------EEEDESSSSGGGEEESSAESLVGSSGG 131
            + E  SE + E    AG+   E+   E       EE     S   EEE   E   G + G
Sbjct: 1291 DREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADG 1350

Query: 132  SSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSS---VVSSGGDEG 188
            +  D        A+S+ S D D    L + K   G    G GG++S        + G   
Sbjct: 1351 AEED--------ASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSF 1402

Query: 189  YGTGGGGSSATSGGRRGSLEMSSDGE------PLSRMDSEDSISSTIMDVDSTISSGRST 242
               G       + GR+   +   DG       P    + E+    T  +V  +       
Sbjct: 1403 KFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEA 1462

Query: 243  PAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVC--LWK 300
            PA    + +   S          D   A    S + +D  +    D  +          K
Sbjct: 1463 PAEKLAEETEGPS----------DGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKK 1512

Query: 301  GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360
             C V N    S   L RHM +H+G++P+KC    C  +F  +  L RH   H  +   +K
Sbjct: 1513 VCSVCNKRFWSLQDLTRHMRSHTGERPYKCQT--CERTFTLKHSLVRHQRIH-QKARHAK 1569

Query: 361  VSSQPKAKEESPSKAGMNK 379
               +   KEE   +   N+
Sbjct: 1570 HHGKDSDKEERGEEDSENE 1588



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 38/147 (25%), Positives = 63/147 (42%), Gaps = 28/147 (19%)

Query: 207 LEMSSDGEPLSRMDSEDSISSTIMDVD----STISSGRSTPAMMNGQGSTTSSSKNIAYN 262
           LE  S  E L  +  E  I   I + +     T   G+ TPAM           + + Y 
Sbjct: 596 LEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAM-----------RKVLYP 644

Query: 263 CCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTH 322
           C +  C   F  S  L  H+RS H+        +  ++ C + +  +  ++ L RH+ TH
Sbjct: 645 CRF--CNQVFAFSGVLRAHVRS-HLG-------ISPYQ-CNICDYIAADKAALIRHLRTH 693

Query: 323 SGDKPFKCVVGGCNASFASQGGLARHV 349
           SG++P+ C +  C+  F  +    RH+
Sbjct: 694 SGERPYICKI--CHYPFTVKANCERHL 718



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 43/180 (23%), Positives = 58/180 (32%), Gaps = 54/180 (30%)

Query: 30   RGRAEPPEEE-------------EEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGG 76
            RG +  PEEE             EE+    +  + +    L+    + G G  G GG   
Sbjct: 1329 RGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAAS 1388

Query: 77   GE-----------------------AETMSEPSPESASQAGEDEDEEEDDEEEEDE---- 109
             E                       A    EP  E    A   E+  +   E+E++    
Sbjct: 1389 QEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPET 1448

Query: 110  -----SSSSGGGE--EESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPK 162
                  S+ G GE   E  AE   G S G S+ E R       SS   D D K   + PK
Sbjct: 1449 PAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKR-------SSEKSDDDKKPKTDSPK 1501



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 18/59 (30%), Positives = 29/59 (49%)

Query: 90   ASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSS 148
            A   G+D D+EE  EE+ +  S+  G    S  E+ +  +  +    TRS   G AS++
Sbjct: 1568 AKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASAT 1626


>gi|51173737 ras responsive element binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1742

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 53/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)

Query: 217 SRMDSEDSISSTIMDVDSTISSGRSTPAMMN----------GQGSTTSSSKNIAYNCCWD 266
           S + S +++ S +M V     +G S   + +          G+ +  +  +  +YNC   
Sbjct: 12  SDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETKEEKSSYNC--P 69

Query: 267 QCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDK 326
            C+    +   L  HIR  + D   GG        C +     +S S L RHML HSG++
Sbjct: 70  LCEKICTTQHQLTMHIRQHNTD--TGGAD----HSCSICGKSLSSASSLDRHMLVHSGER 123

Query: 327 PFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNK 386
           P+KC V  C  SF + G + RH+  H    NS+  ++ P     SP      KRR+L +K
Sbjct: 124 PYKCTV--CGQSFTTNGNMHRHMKIHEKDPNSATATAPP-----SPL-----KRRRLSSK 171

Query: 387 RRRS 390
           R+ S
Sbjct: 172 RKLS 175



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 73/319 (22%), Positives = 110/319 (34%), Gaps = 38/319 (11%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDE------EEEDESSSSGGGEEESSAESLVGSSGG 131
            + E  SE + E    AG+   E+   E       EE     S   EEE   E   G + G
Sbjct: 1346 DREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADG 1405

Query: 132  SSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSS---VVSSGGDEG 188
            +  D        A+S+ S D D    L + K   G    G GG++S        + G   
Sbjct: 1406 AEED--------ASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSF 1457

Query: 189  YGTGGGGSSATSGGRRGSLEMSSDGE------PLSRMDSEDSISSTIMDVDSTISSGRST 242
               G       + GR+   +   DG       P    + E+    T  +V  +       
Sbjct: 1458 KFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEA 1517

Query: 243  PAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVC--LWK 300
            PA    + +   S          D   A    S + +D  +    D  +          K
Sbjct: 1518 PAEKLAEETEGPS----------DGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKK 1567

Query: 301  GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSK 360
             C V N    S   L RHM +H+G++P+KC    C  +F  +  L RH   H  +   +K
Sbjct: 1568 VCSVCNKRFWSLQDLTRHMRSHTGERPYKCQT--CERTFTLKHSLVRHQRIH-QKARHAK 1624

Query: 361  VSSQPKAKEESPSKAGMNK 379
               +   KEE   +   N+
Sbjct: 1625 HHGKDSDKEERGEEDSENE 1643



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 19/36 (52%), Positives = 24/36 (66%), Gaps = 2/36 (5%)

Query: 313  SWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARH 348
            S LQRHMLTH+G KPF C    C+A F+++    RH
Sbjct: 1259 SSLQRHMLTHTGQKPFPC--QKCDAFFSTKSNCERH 1292



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 38/147 (25%), Positives = 63/147 (42%), Gaps = 28/147 (19%)

Query: 207 LEMSSDGEPLSRMDSEDSISSTIMDVD----STISSGRSTPAMMNGQGSTTSSSKNIAYN 262
           LE  S  E L  +  E  I   I + +     T   G+ TPAM           + + Y 
Sbjct: 596 LEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAM-----------RKVLYP 644

Query: 263 CCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTH 322
           C +  C   F  S  L  H+RS H+        +  ++ C + +  +  ++ L RH+ TH
Sbjct: 645 CRF--CNQVFAFSGVLRAHVRS-HLG-------ISPYQ-CNICDYIAADKAALIRHLRTH 693

Query: 323 SGDKPFKCVVGGCNASFASQGGLARHV 349
           SG++P+ C +  C+  F  +    RH+
Sbjct: 694 SGERPYICKI--CHYPFTVKANCERHL 718



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 43/180 (23%), Positives = 58/180 (32%), Gaps = 54/180 (30%)

Query: 30   RGRAEPPEEE-------------EEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGG 76
            RG +  PEEE             EE+    +  + +    L+    + G G  G GG   
Sbjct: 1384 RGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAAS 1443

Query: 77   GE-----------------------AETMSEPSPESASQAGEDEDEEEDDEEEEDE---- 109
             E                       A    EP  E    A   E+  +   E+E++    
Sbjct: 1444 QEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPET 1503

Query: 110  -----SSSSGGGE--EESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPK 162
                  S+ G GE   E  AE   G S G S+ E R       SS   D D K   + PK
Sbjct: 1504 PAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKR-------SSEKSDDDKKPKTDSPK 1556



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 18/59 (30%), Positives = 29/59 (49%)

Query: 90   ASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSS 148
            A   G+D D+EE  EE+ +  S+  G    S  E+ +  +  +    TRS   G AS++
Sbjct: 1623 AKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASAT 1681


>gi|86991432 GLI-Kruppel family member GLI2 [Homo sapiens]
          Length = 1586

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 1/95 (1%)

Query: 262 NCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLT 321
           NC W+ C   +++   L  HI + H+ G++   FVC W+ C     P  +Q  L  HM  
Sbjct: 438 NCHWEDCTKEYDTQEQLVHHINNEHIHGEKKE-FVCRWQACTREQKPFKAQYMLVVHMRR 496

Query: 322 HSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           H+G+KP KC   GC+ +++    L  H+ +H  ++
Sbjct: 497 HTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEK 531



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 15/124 (12%)

Query: 261 YNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRHM 319
           + C ++ C   ++   +L  H+RS H  G++   +VC  +GC K ++  S       R  
Sbjct: 503 HKCTFEGCSKAYSRLENLKTHLRS-HT-GEKP--YVCEHEGCNKAFSNASDRAKHQNR-- 556

Query: 320 LTHSGDKPFKCVVGGCNASFASQGGLARHVPT------HFSQQNSSKVSSQ-PKAKEESP 372
            THS +KP+ C + GC   +     L +HV T      H +++  + V  + P  KE   
Sbjct: 557 -THSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGD 615

Query: 373 SKAG 376
           S+AG
Sbjct: 616 SEAG 619


>gi|119393899 GLI-Kruppel family member GLI3 [Homo sapiens]
          Length = 1580

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 8/169 (4%)

Query: 194 GGSSATSGGRRGSLEMSSDGEPL----SRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQ 249
           G S ++         +SS G+P+    S++  ++ + S           G +T     G 
Sbjct: 408 GPSESSQNKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEG-TTLVKEEGD 466

Query: 250 GSTTSSSKNIAY--NCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNT 307
              +     + Y  NC W+ C   F++   L  HI + H+ G++   FVC W  C     
Sbjct: 467 KDESKQEPEVIYETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKE-FVCRWLDCSREQK 525

Query: 308 PSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           P  +Q  L  HM  H+G+KP KC   GC  +++    L  H+ +H  ++
Sbjct: 526 PFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEK 574



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/120 (25%), Positives = 55/120 (45%), Gaps = 14/120 (11%)

Query: 261 YNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRHM 319
           + C ++ C   ++   +L  H+RS H  G++   +VC  +GC K ++  S       R  
Sbjct: 546 HKCTFEGCTKAYSRLENLKTHLRS-HT-GEKP--YVCEHEGCNKAFSNASDRAKHQNR-- 599

Query: 320 LTHSGDKPFKCVVGGCNASFASQGGLARHVPT------HFSQQNSSKVSSQPKAKEESPS 373
            THS +KP+ C + GC   +     L +HV T      H +++    +  +P    +S S
Sbjct: 600 -THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGS 658


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 58/189 (30%), Positives = 69/189 (36%), Gaps = 18/189 (9%)

Query: 26   GSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEP 85
            G    G  E  E E + EEE EE E E        G  G G G    G G GE E   E 
Sbjct: 842  GEEEEGEGEEEEGEGKGEEEGEEGEGEE------EGEEGEGEGEEEEGEGEGEEEGEGEG 895

Query: 86   SPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAA 145
              E     GE+E E E +EEE +      G E E   E   G   G   +       G  
Sbjct: 896  EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW 955

Query: 146  SSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRG 205
                 +G+G EG EE +G  G +G G G            +EG G G        G   G
Sbjct: 956  EGEEEEGEG-EGEEEGEG-EGEEGEGEGEE----------EEGEGEGEEEEGEEEGEEEG 1003

Query: 206  SLEMSSDGE 214
              E   +GE
Sbjct: 1004 EGEEEGEGE 1012



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 62/201 (30%), Positives = 74/201 (36%), Gaps = 19/201 (9%)

Query: 26   GSAARGRAEPPEEEE---EEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETM 82
            G    G  E  EE E   EEEE E E E E         G G G   G  G G GE    
Sbjct: 878  GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE---- 933

Query: 83   SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
             E   E   + GE E EEE+ E E +E    G GEEE   E   G   G   +       
Sbjct: 934  -EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEE------- 985

Query: 143  GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG 202
            G       +G+ +EG EE +G    +G G             G+EG G G        G 
Sbjct: 986  GEGEGEEEEGE-EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGE 1044

Query: 203  RRGSLEMSSDGEPLSRMDSED 223
             R   E   +GE   R   E+
Sbjct: 1045 ER---EKEGEGEENRRNREEE 1062



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 49/145 (33%), Positives = 58/145 (40%), Gaps = 23/145 (15%)

Query: 26   GSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEP 85
            G    G  E  EEE E E EEEE E E         G   G G G  G G GE E     
Sbjct: 939  GEGEDGEGEGEEEEGEWEGEEEEGEGE---------GEEEGEGEGEEGEGEGEEE----- 984

Query: 86   SPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAE---SLVGSSGGSSSDETRSLSP 142
              E   +  E+E EEE +EE E E    G GEEE   E    + G  G    +E      
Sbjct: 985  --EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE 1042

Query: 143  GAASSSSGDGD----GKEGLEEPKG 163
            G      G+G+     +E  EE +G
Sbjct: 1043 GEEREKEGEGEENRRNREEEEEEEG 1067



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 59/195 (30%), Positives = 72/195 (36%), Gaps = 19/195 (9%)

Query: 30  RGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPES 89
           R   E   EEE ++ E EE E E           GG   GG    G GE E   E   E 
Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGE---EKEEGGEVEGGEVEEGKGEREE-EEEEGEG 835

Query: 90  ASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSS 149
             + GE E+EE + EEEE E      GEE    E   G  G    +E      G      
Sbjct: 836 EEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEE--GEEGEGEGEEEEGEGEG---EEE 890

Query: 150 GDGDGK------EGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD----EGYGTGGGGSSAT 199
           G+G+G+      EG EE +G    + G G G          G+    EG G  G G    
Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE 950

Query: 200 SGGRRGSLEMSSDGE 214
             G     E   +GE
Sbjct: 951 EEGEWEGEEEEGEGE 965



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 54/182 (29%), Positives = 67/182 (36%), Gaps = 9/182 (4%)

Query: 34  EPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQA 93
           E  E E E E+EE E + E  A     G   G  G G      G  E   E       + 
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819

Query: 94  GEDEDEEEDDEEE-EDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDG 152
            E + E E++EEE E E     G EEE   E   G   G    E      G      G+G
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE---GEGEEEGEEGEG 876

Query: 153 DGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSD 212
           +G+E  EE +G    +G G G          G +EG G G        G   G  E   +
Sbjct: 877 EGEE--EEGEGEGEEEGEGEGEEEEGE--GEGEEEGEGEGEEEEGEGKGEEEGE-EGEGE 931

Query: 213 GE 214
           GE
Sbjct: 932 GE 933



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 51/183 (27%), Positives = 66/183 (36%), Gaps = 17/183 (9%)

Query: 37  EEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGED 96
           EEEE + EEEEE E E            G   G G  V G   +   E   E  +   E 
Sbjct: 739 EEEEGDREEEEEKEGE------------GKEEGEGEEVEGEREKEEGERKKEERAGKEEK 786

Query: 97  EDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKE 156
            +EE D  E E+E +   G E+E   E   G       +       G      G+G+ +E
Sbjct: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE 846

Query: 157 G---LEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG--RRGSLEMSS 211
           G    EE +G    +G  G G          G+E  G G G       G    G  E   
Sbjct: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906

Query: 212 DGE 214
           +GE
Sbjct: 907 EGE 909



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 50/196 (25%), Positives = 68/196 (34%), Gaps = 31/196 (15%)

Query: 25  PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSE 84
           PG   +  AE  E ++ + EE+E+ E E                       G + E   E
Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQ----------------------GHQKERNQE 726

Query: 85  PSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGA 144
                  + GE E+EE D EEEE++    G G+EE   E + G       +  +    G 
Sbjct: 727 MEEGGEEEHGEGEEEEGDREEEEEKE---GEGKEEGEGEEVEGEREKEEGERKKEERAGK 783

Query: 145 ASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGG------DEGYGTGGGGSSA 198
                 +GD  EG EE    RG +   GG      V    G      +EG G    G   
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843

Query: 199 TSGGRRGSLEMSSDGE 214
              G     E    GE
Sbjct: 844 EEEGEGEEEEGEGKGE 859



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 47/166 (28%), Positives = 56/166 (33%), Gaps = 16/166 (9%)

Query: 23   GSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETM 82
            G       G  E  E E EEE E E  E E        G  G G G    G G GE    
Sbjct: 887  GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946

Query: 83   SEPSPESASQAGEDEDEEEDDEEEEDESSSSGG---------------GEEESSAESLVG 127
                 E   +  E+E E E +EE E E     G               GEEE   E    
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006

Query: 128  SSG-GSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGG 172
              G G   +E      G      G+G+G+E   E +G    + G G
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 49/164 (29%), Positives = 58/164 (35%), Gaps = 16/164 (9%)

Query: 26   GSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGG---GGGGGVGGGEAETM 82
            G    G  E  EEE E E EEEE E E         G   G G   G G G    E E  
Sbjct: 972  GEGEEGEGEGEEEEGEGEGEEEEGEEE---------GEEEGEGEEEGEGEGEEEEEGEVE 1022

Query: 83   SEPSPESASQAGEDEDEEEDDEEEEDE---SSSSGGGEEESSAESLVGSSGGSSSDETRS 139
             E   E     GE+E+ EE+ EE E E     +    EEE   E     +G   ++    
Sbjct: 1023 GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDG 1082

Query: 140  LSPGAASSSSGDGD-GKEGLEEPKGPRGSQGGGGGGSSSSSVVS 182
                  S   G    GK    + K    +QG G    S   V S
Sbjct: 1083 EEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQS 1126



 Score = 32.7 bits (73), Expect = 0.82
 Identities = 37/131 (28%), Positives = 50/131 (38%), Gaps = 12/131 (9%)

Query: 87  PESASQAGEDEDEEEDDEEEEDESSSSGGGEEE--SSAESLVGSSGGSSSDETRSLSPGA 144
           P +  +A  DE+ E  +E+E  E S   G EE+   + E  V   GG   ++T  LS   
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGG-RKEKTEILSDDL 630

Query: 145 ASSSS-GDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGR 203
              +   +G  K   E   GP G   G G     SS      DE    G           
Sbjct: 631 TDKAEVSEGKAKSVGEAEDGPEGR--GDGTCEEGSSGAEHWQDEEREKGEKDKG------ 682

Query: 204 RGSLEMSSDGE 214
           RG +E   +GE
Sbjct: 683 RGEMERPGEGE 693



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 45/198 (22%), Positives = 67/198 (33%), Gaps = 43/198 (21%)

Query: 34  EPPEEEEEEEE------EEEEAEA-----------EAVAALLLNGGSGGGGGGGGGGVGG 76
           E PEE+E  E+      EE+E EA           +    +L +  +       G     
Sbjct: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSV 644

Query: 77  GEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDE 136
           GEAE   E   +   + G    E   DEE E      G GE E   E   G    +  +E
Sbjct: 645 GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE---GEKELAEKEE 701

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
            +            DG+ +E  E  +G +            +  +  GG+E +G G    
Sbjct: 702 WK----------KRDGEEQEQKEREQGHQ---------KERNQEMEEGGEEEHGEG---- 738

Query: 197 SATSGGRRGSLEMSSDGE 214
               G R    E   +G+
Sbjct: 739 EEEEGDREEEEEKEGEGK 756


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 71/252 (28%), Positives = 85/252 (33%), Gaps = 35/252 (13%)

Query: 27   SAARGRAEPPEEEE-----EEEEEEEEAEAEAVAALLLNGGSGGGG----------GGGG 71
            S A+G   P EE E     + E        +A  ALLL    G GG          G   
Sbjct: 2446 SGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYP 2505

Query: 72   GGVGGGE----------AETMSEPSP-----ESASQAGEDEDEEEDDEEEEDESSSSGGG 116
               G  E           +   EP P     +S +    D+ + E D  EE ESSSS   
Sbjct: 2506 PAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSS-- 2563

Query: 117  EEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSS 176
               SS  S   SS  SS  ET     G  +   G G G            S       SS
Sbjct: 2564 ---SSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSS 2620

Query: 177  SSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTI 236
            SSS  SS       +    SS++S     S   SS     S   S  S SST  +  S  
Sbjct: 2621 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCS 2680

Query: 237  SSGRSTPAMMNG 248
            S   + PA   G
Sbjct: 2681 SDDEAAPAPTAG 2692



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 42/170 (24%), Positives = 63/170 (37%), Gaps = 7/170 (4%)

Query: 23   GSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGS-------GGGGGGGGGGVG 75
            G+P S  + +AE    EE E      + + + ++   + GS       G   G GG G G
Sbjct: 2539 GNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTG 2598

Query: 76   GGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSD 135
            G      S  +   AS +                SSSS      SS+ S   SS  SSS 
Sbjct: 2599 GRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2658

Query: 136  ETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGG 185
             + S S  ++SSS+ D D     ++   P  + G     +  +      G
Sbjct: 2659 SSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAG 2708



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 28/75 (37%), Positives = 34/75 (45%), Gaps = 16/75 (21%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDEEE--EDESSSSGGGEEESSAESLVGSSGGSSSD 135
            EAE  S  S  S     +DE  EE+DEEE  E+E  +SGGG    + E            
Sbjct: 1806 EAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLGARE------------ 1853

Query: 136  ETRSLSPGAASSSSG 150
              R+LSPG   S  G
Sbjct: 1854 --RALSPGLEESGLG 1866


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 57/268 (21%), Positives = 103/268 (38%), Gaps = 10/268 (3%)

Query: 27  SAARGRAEPPEEEEEEE--------EEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGE 78
           S++RG A    +E ++          E++++++ +      + G+G  G         G+
Sbjct: 485 SSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGK 544

Query: 79  AETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSS--SDE 136
            ++ S  S  S S    D  +  D +  +  SSS     +  S++S    S  SS  SD 
Sbjct: 545 GKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDS 604

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
           + S     +S SS   D K    + +            S S+S  SS   +   +    +
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664

Query: 197 SATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
           S+ S     S + SS  +  +  DS DS  S+     S  S    + +  +   S ++SS
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724

Query: 257 KNIAYNCCWDQCQACFNSSPDLADHIRS 284
            + + N       +  + S D +D   S
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNS 752



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 46/182 (25%), Positives = 71/182 (39%), Gaps = 1/182 (0%)

Query: 78  EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEE-ESSAESLVGSSGGSSSDE 136
           ++++    S +S+     D     D  +  D S SS   +  +S ++S    S  S SD 
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
               S   +S SS + D  +          S       SSSSS  S+  D    +    S
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698

Query: 197 SATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
           S +S     S   SSD    S  +S DS SS   D   + +S  S+ +  +   S +S S
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 257 KN 258
            +
Sbjct: 759 SD 760



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 53/264 (20%), Positives = 97/264 (36%), Gaps = 15/264 (5%)

Query: 6   TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAE----AEAVAALLLNG 61
           +D +D    S  S     S  S +   +E  +  +  + +  ++     + +  +   N 
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNS 731

Query: 62  GSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESS 121
                           ++   S+ S  S S    D  +  D  +  D S+SS   +  +S
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS 791

Query: 122 AESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVV 181
           ++S    S  S+S ++ + S  + SS S D D     +       S       SS SS  
Sbjct: 792 SDS----SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS 847

Query: 182 SSGGD-------EGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDS 234
           S G D       +   +     S+ S     S + S   E  +  DS DS +S+  D   
Sbjct: 848 SDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907

Query: 235 TISSGRSTPAMMNGQGSTTSSSKN 258
           + +S  S+ +  +   S +S+S +
Sbjct: 908 SSNSSDSSDSSNSSDSSESSNSSD 931



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 49/182 (26%), Positives = 70/182 (38%), Gaps = 3/182 (1%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           S+ S  S S    D  +  D     D S+SS   +   S+ S   S    SSD   S S 
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG 202
            +++S+S D D     +       S       SS+SS  S   D    +    SS +S  
Sbjct: 717 DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDS 776

Query: 203 RRGSLEMSSDGEPLSRMDSEDSISS--TIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIA 260
              S   S   +  +  DS DS +S  +    DS+ SS  S     N   S+ SS  + +
Sbjct: 777 SDSS-NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835

Query: 261 YN 262
            N
Sbjct: 836 SN 837



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 45/176 (25%), Positives = 68/176 (38%), Gaps = 8/176 (4%)

Query: 83   SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
            S+ S  S S    D  +  D  +  D S+SS   +   S++S   S   +SSD + S   
Sbjct: 974  SDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDS 1033

Query: 143  GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG 202
              +S SS   D  +  +       S       SS SS  S   D    +    SS +S  
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN- 1092

Query: 203  RRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKN 258
               S + S   +     DS DS  S+    DS+ SS  S  +  +    ++ SS +
Sbjct: 1093 ---SSDSSDSSDSSDSSDSSDSSDSS----DSSDSSNSSDSSDSSDSSDSSDSSNS 1141



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 55/253 (21%), Positives = 91/253 (35%), Gaps = 8/253 (3%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAA--RGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGS 63
            +D +D    S  S     S GS +    R++     +  +  +    +++  +   N  S
Sbjct: 830  SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889

Query: 64   GGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAE 123
                          ++   S  S  S S    D  E  +  +  + S SS   +   S++
Sbjct: 890  NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949

Query: 124  SLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSS 183
            S   S   +SSD + S S  + S+SS   D     +       S       SS+SS  S 
Sbjct: 950  SSNSSDSSNSSDSSNS-SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008

Query: 184  GGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTP 243
              D    +    SS +S     S + S   +     DS DS  S+    DS+ SS  S  
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSS-DSSDSSDSSDSSDSSDSSDSS----DSSNSSDSSDS 1063

Query: 244  AMMNGQGSTTSSS 256
            +  +    ++ SS
Sbjct: 1064 SDSSDSSDSSDSS 1076



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 42/162 (25%), Positives = 62/162 (38%)

Query: 95  EDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDG 154
           +D+  + DD    DES+ +     ES   S        +SDE++    G+ S  + D D 
Sbjct: 456 DDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDS 515

Query: 155 KEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGE 214
               +         G  G   +  S    G  +   +    SS +S     S   SSD  
Sbjct: 516 DSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSN 575

Query: 215 PLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
             S  DS DS SS   D DS+ SS  S  +  +    ++ SS
Sbjct: 576 SSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS 617



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 52/256 (20%), Positives = 91/256 (35%), Gaps = 10/256 (3%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            +D ++  + S  S     S  S +   ++  +  E     +    + +  +   +  +  
Sbjct: 853  SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS 912

Query: 66   GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEED-----ESSSSGGGEEES 120
                        E+   S+ S  S S    D  +  D     D     +SS+S    + +
Sbjct: 913  DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972

Query: 121  SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180
            S++S   S+   SSD + S     +S SS   D  +  +       S       SS+SS 
Sbjct: 973  SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 181  VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240
             S   D    +    SS +S     S + S   +     DS DS  S+    DS+ SS  
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSS-DSSDSSDSSDSSDSSDSSDSS----DSSESSDS 1087

Query: 241  STPAMMNGQGSTTSSS 256
            S  +  +    ++ SS
Sbjct: 1088 SDSSNSSDSSDSSDSS 1103



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 8/179 (4%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDET 137
            ++   S+ S  S S    D  +  D  +  D S+SS   +   S++S   S+   SSD +
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148

Query: 138  RSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSS 197
             S     +S SS   D  +  +       S       SS SS  S   D    +    SS
Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1208

Query: 198  ATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
             +S     S + S   +     DS DS  S+    DS+ SS  S  +  +    ++ SS
Sbjct: 1209 DSSD----SSDSSDSSDSSDSSDSSDSNESS----DSSDSSDSSDSSNSSDSSDSSDSS 1259



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 45/180 (25%), Positives = 70/180 (38%), Gaps = 6/180 (3%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEED--ESSSSGGGEEESSAESLVGSSGGSSSDETRSL 140
           S  S +S S + + E +  D + + D  +S+SS   +   S++S   S+   SSD + S 
Sbjct: 616 SSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSS 675

Query: 141 SPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATS 200
              ++S SS   D  +  +       S       S SS    S       +    SS +S
Sbjct: 676 DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735

Query: 201 GGRRGSLEMSSDGEPLSRMDSEDSISSTIMD----VDSTISSGRSTPAMMNGQGSTTSSS 256
                S    S     S   S+ S SS   D     DS+ SS  S  +  N   +++ SS
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 45/257 (17%), Positives = 93/257 (36%), Gaps = 6/257 (2%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            ++ +D  + S  S     S  S +   ++  +  +  + +   +   + ++   +  +  
Sbjct: 780  SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839

Query: 66   GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDE----EEDDEEEEDESSSSGGGEEESS 121
                      G ++++ +     ++S + +  D     +  D  + +ESS+S    + S+
Sbjct: 840  DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899

Query: 122  AESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVV 181
            +     S   +SSD + S +   +S SS   D     +       S       SS SS  
Sbjct: 900  SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959

Query: 182  SSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRS 241
            S   +    +    S ++          SSD    S  DS DS +S+     S  S   +
Sbjct: 960  SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS--DSSDSSNSSDSSDSSDSSDSSN 1017

Query: 242  TPAMMNGQGSTTSSSKN 258
            +    N   S+ SS  +
Sbjct: 1018 SSDSSNSSDSSNSSDSS 1034



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 53/261 (20%), Positives = 86/261 (32%), Gaps = 8/261 (3%)

Query: 6    TDMADLEELSRLSPL--------PPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAAL 57
            +D +D  E S  S             S  S +   ++     +  E       + +  + 
Sbjct: 880  SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSS 939

Query: 58   LLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGE 117
              +  S                 + S  S +S S    D     D  +  D S SS   +
Sbjct: 940  NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999

Query: 118  EESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSS 177
              +S++S   S    SS+ + S +   +S+SS   D  +  +       S       SS 
Sbjct: 1000 SSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1059

Query: 178  SSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTIS 237
            SS  S   D    +    SS +S     S   +S     S   S+ S SS   D   +  
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119

Query: 238  SGRSTPAMMNGQGSTTSSSKN 258
            S  S+ +  +   S +S S N
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSN 1140



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 53/262 (20%), Positives = 93/262 (35%), Gaps = 7/262 (2%)

Query: 25  PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSE 84
           P S+           E +       +A   +    + G+G    G         ++T + 
Sbjct: 465 PNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNS 524

Query: 85  PSPESASQAGEDEDEEE-----DDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRS 139
            S  + +   +D D+ +      D  + D S SS   +   S++S   S   SSSD   S
Sbjct: 525 DSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDS-DSSDSNSSSDSDSS 583

Query: 140 LSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSAT 199
            S  + SS S   D     +       S       SS S   SS  +         S ++
Sbjct: 584 DSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSS 643

Query: 200 SGGRRGSLEMSSDGEPLSRMDSEDSI-SSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKN 258
                 S + S   +  +  +S DS  SS   D  S+  S  S+ +  +   S +S S +
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSD 703

Query: 259 IAYNCCWDQCQACFNSSPDLAD 280
            + +   D   +  +S+ + +D
Sbjct: 704 SSDSSDSDSSDSSDSSNSNSSD 725



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 4/257 (1%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            +D +D  + S  S     S  S +   ++     +     +    +++  +   +  S  
Sbjct: 992  SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051

Query: 66   GGGGGGGGVGGGEAETMSEPSPESA--SQAGEDED--EEEDDEEEEDESSSSGGGEEESS 121
                           + S  S +S+  S + E  D  +  +  +  D S SS   +   S
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111

Query: 122  AESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVV 181
            ++S   S   +SSD + S     +S SS   D  +  E       S       SS SS  
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171

Query: 182  SSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRS 241
            S   D    +    SS +S     S    S     S   S+ S SS   D   +  S  S
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1231

Query: 242  TPAMMNGQGSTTSSSKN 258
              +  +   S +S S N
Sbjct: 1232 NESSDSSDSSDSSDSSN 1248



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 55/255 (21%), Positives = 89/255 (34%), Gaps = 7/255 (2%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            +D +D  + S  S     S  S +   ++  +  +  +  +    +E+  +   +  +  
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS--DSSNSS 1094

Query: 66   GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGG-EEES--SA 122
                        ++   S+ S  S S    D  +  D  +  D S+SS      ES  S+
Sbjct: 1095 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154

Query: 123  ESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVS 182
            +S   S    SSD + S     +S+SS   D  +  +       S       SS SS  S
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214

Query: 183  SGGDEGYGTGGGGSSAT--SGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240
               D    +    SS +  S     S + S         DS DS  ST    D + S  +
Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSK 1274

Query: 241  STPAMMNGQGSTTSS 255
            S     NG  S + S
Sbjct: 1275 SGNGNNNGSDSDSDS 1289



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/173 (24%), Positives = 68/173 (39%), Gaps = 6/173 (3%)

Query: 86  SPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAA 145
           S +S S++   +    D  +  D S SS       S++S   S   SSSD + S     +
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 146 SSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRG 205
           S SS   +  +  +               +SS S  S+  D    +    SS +S     
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 206 SLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKN 258
           S + S   +  +  DS DS  S+    DS+ SS  S+ +  +   S +S S N
Sbjct: 753 S-DSSDSSDSSNSSDSSDSSDSS----DSSDSS-NSSDSNDSSNSSDSSDSSN 799



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 42/176 (23%), Positives = 63/176 (35%), Gaps = 1/176 (0%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           S  S +S+  +   + + +  + E D SS S    + S + S   S    SSD + S + 
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESD-SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG 202
             +S SS   D     +       S       SS SS  S   D         S++ S  
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725

Query: 203 RRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKN 258
              S    S     S   S+ S SS   D   +  S  S+ +  +   S +S S N
Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 51/204 (25%), Positives = 74/204 (36%), Gaps = 9/204 (4%)

Query: 64  GGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDD-EEEEDESSSSGGGEEESSA 122
           G    G      G ++    + S +       DE    DD   E D +SSS G    +S 
Sbjct: 437 GHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSD 496

Query: 123 ESLVGSSG----GSSSDETRSLSPGAASSSSGDG----DGKEGLEEPKGPRGSQGGGGGG 174
           ES    +G    G+  D++ S S    S S+G+G    D  +  +  KG   S       
Sbjct: 497 ESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSD 556

Query: 175 SSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDS 234
           SS+SS  S   D         S + S     S    SD    S        S +    DS
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616

Query: 235 TISSGRSTPAMMNGQGSTTSSSKN 258
           + SS   + +  +   S+ S SK+
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKS 640



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 51/258 (19%), Positives = 87/258 (33%), Gaps = 7/258 (2%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            +D ++  + S  S     S  S +            +  +  ++   + ++   N     
Sbjct: 948  SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007

Query: 66   GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES----- 120
                        ++   S+ S  S S    D  +  D  +  D S SS     +S     
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN--SSDSSDSSD 1065

Query: 121  SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180
            S++S   S    SSD + S     +S+SS   D  +  +       S       SS+SS 
Sbjct: 1066 SSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1125

Query: 181  VSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGR 240
             S   D    +    SS +S     S    S     S   S+ S SS   D  ++  S  
Sbjct: 1126 SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1185

Query: 241  STPAMMNGQGSTTSSSKN 258
            S+ +  +   S +S S +
Sbjct: 1186 SSDSSDSSDSSDSSDSSD 1203



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 44/176 (25%), Positives = 66/176 (37%), Gaps = 3/176 (1%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           S  S +S   +   +  +  +  +   SS S    + S ++S   S   +SSD + S + 
Sbjct: 779 SSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNS 838

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGG 202
             +S SS   DG +  +       S       SS SS  S   D         SS +S  
Sbjct: 839 SDSSDSSDSSDGSDS-DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897

Query: 203 RRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKN 258
              S   SSD    S  DS DS +S+     S  S   ++    N   S+ SS  +
Sbjct: 898 SNSSDSDSSDSSNSS--DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS 951



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 36/186 (19%), Positives = 63/186 (33%), Gaps = 2/186 (1%)

Query: 6    TDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGG 65
            +D +D    S  S     S  S +   ++  +  E  +  +    +++  +   +     
Sbjct: 1115 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSS--DSSDSS 1172

Query: 66   GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESL 125
                        ++   S+ S  S S    D  +  D  +  D S SS   +   S++S 
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSN 1232

Query: 126  VGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGG 185
              S    SSD + S +   +S SS   D      +    +   G G    S S   S G 
Sbjct: 1233 ESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGS 1292

Query: 186  DEGYGT 191
            D  + T
Sbjct: 1293 DSNHST 1298



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 3/184 (1%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSS-GGGEEES--SAESLVGSSGGSSS 134
            E+   S+ S  S S    D  +  D  +  D S SS      +S  S++S   S   +SS
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142

Query: 135  DETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGG 194
            D + S     +S SS   D  +  +       S       SS SS  S   D    +   
Sbjct: 1143 DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202

Query: 195  GSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTS 254
             SS +S     S    S     S   S+ + SS   D   +  S  S+ +  +   S ++
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDST 1262

Query: 255  SSKN 258
            S  N
Sbjct: 1263 SDSN 1266



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 5/186 (2%)

Query: 78  EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDET 137
           ++++ S  S  S S    D  +  +     D S SS   +  SS++S   S    SSD +
Sbjct: 637 DSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696

Query: 138 RSL-SPGAASSSSGD----GDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTG 192
            S  S  ++ SS  D     D             S       +SS S  SS       + 
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756

Query: 193 GGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGST 252
               S+ S     S + S   +  +  DS DS +S+     S  S   ++    +   S+
Sbjct: 757 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816

Query: 253 TSSSKN 258
            S S N
Sbjct: 817 DSDSSN 822



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 46/184 (25%), Positives = 64/184 (34%), Gaps = 4/184 (2%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGG-EEES--SAESLVGSSGGSSS 134
            ++   S+ S  S S    D  +  D     D S SS      +S  S++S   S    SS
Sbjct: 1095 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154

Query: 135  DETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGG 194
            D + S     +S SS   D  +          S       SS SS  S   D    +   
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214

Query: 195  GSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTS 254
             SS +S     S + S   E     DS DS  S+     S  S    + +  N +  + S
Sbjct: 1215 DSSDSSDSSDSS-DSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQS 1273

Query: 255  SSKN 258
             S N
Sbjct: 1274 KSGN 1277



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 39/204 (19%), Positives = 74/204 (36%), Gaps = 1/204 (0%)

Query: 78  EAETMSEPSPES-ASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDE 136
           ++   S+ S  S +S +    D  +  +  + +SS+S      S +     SS  S S +
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
           +   S   +S+ S   +  +  +       S       S+ SS  S   D    +    S
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906

Query: 197 SATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
            +++         SSD    S      + S +    DS+ SS  S  +  +    +++SS
Sbjct: 907 DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966

Query: 257 KNIAYNCCWDQCQACFNSSPDLAD 280
            +   N       +  + S D +D
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSD 990



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 47/181 (25%), Positives = 65/181 (35%), Gaps = 15/181 (8%)

Query: 83  SEPSPESA-SQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLS 141
           SEP  +   S  G D + +  D  + D+ S  G  +  SS ES       S SD      
Sbjct: 430 SEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGD-DPNSSDESNGNDDANSESDNN---- 484

Query: 142 PGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS----S 197
               SSS GD        +  G  GS   G     S S   +   +  G G  G+     
Sbjct: 485 ----SSSRGDASYNSDESKDNG-NGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDK 539

Query: 198 ATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSK 257
           + SG  +     S   +  +  DS DS  S   D +S+  S  S     +   S +S S 
Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599

Query: 258 N 258
           N
Sbjct: 600 N 600



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 37/147 (25%), Positives = 53/147 (36%), Gaps = 4/147 (2%)

Query: 78   EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDET 137
            ++   S+ S  S S    D     D  +  D S SS     +SS +S   S    SSD +
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD--SSDSS-DSSDSSDSSDSSDSS 1214

Query: 138  RSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSS 197
             S     +S SS   D  E  +       S       SS SS  S    +        S 
Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSK 1274

Query: 198  ATSGGRRGS-LEMSSDGEPLSRMDSED 223
            + +G   GS  +  S+G   +   S+D
Sbjct: 1275 SGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 36/151 (23%), Positives = 58/151 (38%), Gaps = 6/151 (3%)

Query: 7   DMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGG 66
           D+ D      ++ +    P  A    +   E+E  E     E     +   + +  +G  
Sbjct: 166 DVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTK 225

Query: 67  GGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEE-DDEEEEDESSSSGGGEEESSAESL 125
                 G G       S+ SP S + A EDEDE   DDE+EE    +  G +  ++++  
Sbjct: 226 EAEVTPGTGEDAGLDNSDGSP-SGNGADEDEDEGSGDDEDEE----AGNGKDSSNNSKGQ 280

Query: 126 VGSSGGSSSDETRSLSPGAASSSSGDGDGKE 156
            G   G   D   S+   + S    D +GKE
Sbjct: 281 EGQDHGKEDDHDSSIGQNSDSKEYYDPEGKE 311



 Score = 33.1 bits (74), Expect = 0.63
 Identities = 39/205 (19%), Positives = 74/205 (36%), Gaps = 10/205 (4%)

Query: 85  PSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSL---S 141
           PS  + +   E     E  E++       G G  ++  E +     G  S+    +   +
Sbjct: 381 PSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSN 440

Query: 142 PGAASSSSG------DGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGG 195
            G+ S+S G      D    +G ++P     S G     S S +  SS GD  Y +    
Sbjct: 441 TGSDSNSDGYDSYDFDDKSMQG-DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESK 499

Query: 196 SSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSS 255
            +      +G+ +  SD    +     +   +   D +    SG+      +   S +S+
Sbjct: 500 DNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSN 559

Query: 256 SKNIAYNCCWDQCQACFNSSPDLAD 280
           S + + +   D   +  +S  D +D
Sbjct: 560 SSDSSDSSDSDSSDSNSSSDSDSSD 584



 Score = 32.7 bits (73), Expect = 0.82
 Identities = 57/279 (20%), Positives = 89/279 (31%), Gaps = 53/279 (18%)

Query: 22  PGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAET 81
           PG+   A    ++        +E+E+E   +       NG        G  G   G+   
Sbjct: 231 PGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGK--- 287

Query: 82  MSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVG---SSGGSSSDETR 138
             E   +S+     D  E  D E +ED  +   G +   S E+  G    +G    ++T+
Sbjct: 288 --EDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQ 345

Query: 139 SL----------------------------------SPGAASSSSGDGDGKEGLEEPKGP 164
            L                                  S G  + +   G G EG +E KG 
Sbjct: 346 KLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEG-KEDKGQ 404

Query: 165 RGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDS 224
            G   G G   +   VV+          G G  +  G + G     SD       DS D 
Sbjct: 405 HGMILGKGNVKTQGEVVN--------IEGPGQKSEPGNKVGHSNTGSDSNS-DGYDSYDF 455

Query: 225 ISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSK-NIAYN 262
              ++   D   S   +     N +    SSS+ + +YN
Sbjct: 456 DDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYN 494


>gi|55956899 keratin 9 [Homo sapiens]
          Length = 623

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 50/143 (34%), Positives = 54/143 (37%), Gaps = 17/143 (11%)

Query: 61  GGSGG--GGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEE 118
           GGSGG  GGGG GGG GGG           S S+ G                  SGGG  
Sbjct: 491 GGSGGSYGGGGSGGGYGGG-----------SGSRGGSGGSYGGGS----GSGGGSGGGYG 535

Query: 119 ESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSS 178
             S     G SGG  S  +     G + S  G G G  G    +G  G   GGG G    
Sbjct: 536 GGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGE 595

Query: 179 SVVSSGGDEGYGTGGGGSSATSG 201
           S  S GG E     GGG    SG
Sbjct: 596 SGGSYGGGEEASGSGGGYGGGSG 618



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 50/155 (32%), Positives = 58/155 (37%), Gaps = 3/155 (1%)

Query: 67  GGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLV 126
           GGGGGGG+G G +   S     S+   G               S   G G   S   S  
Sbjct: 15  GGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYG 74

Query: 127 GSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD 186
           G SGG  S    SL  G    S G G    G     G  G   GGG G        SG  
Sbjct: 75  GGSGGGFS--ASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFG 132

Query: 187 EGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDS 221
            G+G  GGG+    GG   + E S+  E  SR+ S
Sbjct: 133 -GFGGFGGGAGGGDGGILTANEKSTMQELNSRLAS 166



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 52/172 (30%), Positives = 58/172 (33%), Gaps = 56/172 (32%)

Query: 43  EEEEEEAEAEAVAALLLNGGSGGGG-------GGGGGGVGGGEAETMSEPSPESASQAGE 95
           E  +E+ E+     + L G  G GG       GG GG  GGG                  
Sbjct: 459 EGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGG------------------ 500

Query: 96  DEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGK 155
                            SGGG    S     GS GGS          G+    SG G G 
Sbjct: 501 ----------------GSGGGYGGGS-----GSRGGSG---------GSYGGGSGSGGGS 530

Query: 156 EGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTG-GGGSSATSGGRRGS 206
            G        G  GG GGG S  S  + GG  G G G GGG    SG R GS
Sbjct: 531 GGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGS 582



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 58/182 (31%), Positives = 73/182 (40%), Gaps = 32/182 (17%)

Query: 60  NGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEE 119
           +GG GGGG G GG +        S  S  S+S  G               SSSSG G   
Sbjct: 14  SGGGGGGGLGSGGSI-------RSSYSRFSSSGGGGGGGR---------FSSSSGYG--- 54

Query: 120 SSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSS 179
             +  + G  GG S   +     G   S+S  G G  G     G RG  G  GGG SSS 
Sbjct: 55  GGSSRVCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGG-----GSRGFGGASGGGYSSSG 109

Query: 180 VVSS--GGDEGYGTGGGGSSATSG-GRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTI 236
                 GG  G G GGG  S   G G  G      DG  L+  +      ST+ +++S +
Sbjct: 110 GFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGGDGGILTANE-----KSTMQELNSRL 164

Query: 237 SS 238
           +S
Sbjct: 165 AS 166



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 29/75 (38%), Positives = 30/75 (40%), Gaps = 1/75 (1%)

Query: 139 SLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSA 198
           +L  G        G GK GL    G  GS G G  G S  S    G   GYG GG GS  
Sbjct: 456 NLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYG-GGSGSRG 514

Query: 199 TSGGRRGSLEMSSDG 213
            SGG  G    S  G
Sbjct: 515 GSGGSYGGGSGSGGG 529



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 26/74 (35%), Positives = 29/74 (39%), Gaps = 12/74 (16%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120
           GGSG GGG GGG  GG            S S+ G             +   S GGGEE S
Sbjct: 560 GGSGSGGGSGGGYGGG------------SGSRGGSGGSHGGGSGFGGESGGSYGGGEEAS 607

Query: 121 SAESLVGSSGGSSS 134
            +    G   G SS
Sbjct: 608 GSGGGYGGGSGKSS 621



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 4/53 (7%)

Query: 61  GGSGGGGGGGGGGVGG----GEAETMSEPSPESASQAGEDEDEEEDDEEEEDE 109
           GG GG GGG GGG GG     E  TM E +   AS   + +  EE + + E++
Sbjct: 132 GGFGGFGGGAGGGDGGILTANEKSTMQELNSRLASYLDKVQALEEANNDLENK 184


>gi|109255251 loricrin [Homo sapiens]
          Length = 312

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 67/217 (30%), Positives = 80/217 (36%), Gaps = 45/217 (20%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120
           G SGGGGGGG GG GGG   ++       +S  G                 SSGGG    
Sbjct: 67  GSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSG-------------CFSSGGGGSGC 113

Query: 121 SAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSV 180
            +    GSSGG S         G  SS  G   G        G  G    GGGG S  +V
Sbjct: 114 FSSGGGGSSGGGS---------GCFSSGGGGSSG--------GGSGCFSSGGGGFSGQAV 156

Query: 181 -------VSSGGDEGYGTG-----GGGSS--ATSGGRRGSLEMSSDGEPLSRMDSEDSIS 226
                  VSSGG  G G+G     GGG S    SGG  G    SS G     + S+  ++
Sbjct: 157 QCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQ-QVT 215

Query: 227 STIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNC 263
            T      +   G S      G G  +S     +  C
Sbjct: 216 QTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGC 252



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 55/169 (32%), Positives = 63/169 (37%), Gaps = 42/169 (24%)

Query: 44  EEEEEAEAEAVAALLLNGGSGGGGGGGGGGVG--GGEAETMSEPSPESASQAGEDEDEEE 101
           ++++      V  +  +GG GGGGG GGGG G  GG             S  G       
Sbjct: 4   QKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGG-----------GGSGGG------- 45

Query: 102 DDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEP 161
                   SS SG G       S  G  GGSS         G      G G G  G  + 
Sbjct: 46  --------SSGSGCGYSGGGGYSGGGCGGGSSGG-------GGGGGIGGCGGGSGGSVKY 90

Query: 162 KGPRGSQGGGGG----GSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGS 206
            G  GS GGG G    G   S   SSGG    G+ GGGS   S G  GS
Sbjct: 91  SGGGGSSGGGSGCFSSGGGGSGCFSSGGG---GSSGGGSGCFSSGGGGS 136



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 51/159 (32%), Positives = 59/159 (37%), Gaps = 14/159 (8%)

Query: 61  GGSGGGGGG----GGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEE------EDES 110
           GGS GGG G    GGGG  G   +  S     S   +G                      
Sbjct: 134 GGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGG 193

Query: 111 SSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGG 170
           S  GGG    S    V S   + +      S G  SS  G G G  G     G  GS G 
Sbjct: 194 SGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGG-GSGGSGCFSSGGGGGSSGC 252

Query: 171 GGG--GSSSSSVVSSGGDE-GYGTGGGGSSATSGGRRGS 206
           GGG  G  S  ++S GG   G G+ GGG   +S G  GS
Sbjct: 253 GGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGS 291



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 45/137 (32%), Positives = 52/137 (37%), Gaps = 32/137 (23%)

Query: 63  SGGGGG------GGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGG 116
           SGGGGG      GGG G GGG           S+  +G      +   +       S GG
Sbjct: 179 SGGGGGSVCGYSGGGSGCGGG-----------SSGGSGSGYVSSQQVTQTSCAPQPSYGG 227

Query: 117 EEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEP---KGPRGSQGGG-- 171
                     GSSGG  S  +   S G    SSG G G  G+       G     GGG  
Sbjct: 228 ----------GSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSS 277

Query: 172 GGGSSSSSVVSSGGDEG 188
           GGG   SSV  SG  +G
Sbjct: 278 GGGGGGSSVGGSGSGKG 294


>gi|39812496 Sp8 transcription factor isoform 1 [Homo sapiens]
          Length = 508

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 91/327 (27%), Positives = 124/327 (37%), Gaps = 54/327 (16%)

Query: 59  LNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEE-------EDDEEEEDESS 111
           ++GGSGGGGGGGGGG      +   +P   S      D  +            E   + S
Sbjct: 151 VSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPS 210

Query: 112 SSGGGEEESSAESLVGSSGGSSSDETRS-----LSPGAASSSSGD-----GDGKEGLEEP 161
             G G     A   VGS+G SS  +  +      +P +A++  G      G  +  L  P
Sbjct: 211 HPGLG-----AAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSP 265

Query: 162 KGPRGSQGGGGGGSSSSSVVSS-----------GGDEGYGTGGGGSSATS--GGRRGSLE 208
            G   S   G   S+ SS  SS            G +    G    SA S   G  GS+ 
Sbjct: 266 LGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSML 325

Query: 209 MSSDGEPLS---RMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCW 265
            +    PL    R  +         D  +   + R  PA         S  +   ++C  
Sbjct: 326 SAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPA-------GASLRRKGLHSCHI 378

Query: 266 DQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGD 325
             C   +  +  L  H+R  H  G+R   FVC W  C    T S     LQRH+ TH+G+
Sbjct: 379 PGCGKVYGKTSHLKAHLRW-HT-GERP--FVCNWLFCGKRFTRSDE---LQRHLRTHTGE 431

Query: 326 KPFKCVVGGCNASFASQGGLARHVPTH 352
           K F C V  CN  F     L++HV TH
Sbjct: 432 KRFACPV--CNKRFMRSDHLSKHVKTH 456



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 42/163 (25%), Positives = 64/163 (39%), Gaps = 17/163 (10%)

Query: 23  GSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETM 82
           GSP  +    ++      +     + + + + A+  + G S    G  G    GG +   
Sbjct: 28  GSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAA 87

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           +  +  +A+ A    D            S S GG   SSA SL  SS  +++      + 
Sbjct: 88  AAAAAAAAAAAALVSD------------SFSCGGSPGSSAFSLTSSSAAAAA-----AAA 130

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGG 185
            AA+SSS   +     + P    GS GGGGGG   SS  S  G
Sbjct: 131 AAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDG 173



 Score = 33.1 bits (74), Expect = 0.63
 Identities = 34/142 (23%), Positives = 49/142 (34%), Gaps = 13/142 (9%)

Query: 85  PSPESASQAGEDEDEEEDDEEEEDESSSSG----GGEEESSAESLVGSSGGSSSDETRSL 140
           PSP S S +     +     +    SSS+     G    S   S    +GGSSS    + 
Sbjct: 32  PSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAA 91

Query: 141 SPGAASS-------SSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD--EGYGT 191
           +  AA++       S G   G            +       ++SSS  ++     +  G 
Sbjct: 92  AAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGV 151

Query: 192 GGGGSSATSGGRRGSLEMSSDG 213
            GG      GG  GS   S DG
Sbjct: 152 SGGSGGGGGGGGGGSSAHSQDG 173



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 14/29 (48%), Positives = 16/29 (55%)

Query: 63  SGGGGGGGGGGVGGGEAETMSEPSPESAS 91
           SGGGGGGG  G G G  +     S  SA+
Sbjct: 457 SGGGGGGGSAGSGSGGKKGSDTDSEHSAA 485


>gi|39812501 Sp8 transcription factor isoform 2 [Homo sapiens]
          Length = 490

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 91/327 (27%), Positives = 124/327 (37%), Gaps = 54/327 (16%)

Query: 59  LNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEE-------EDDEEEEDESS 111
           ++GGSGGGGGGGGGG      +   +P   S      D  +            E   + S
Sbjct: 133 VSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPS 192

Query: 112 SSGGGEEESSAESLVGSSGGSSSDETRS-----LSPGAASSSSGD-----GDGKEGLEEP 161
             G G     A   VGS+G SS  +  +      +P +A++  G      G  +  L  P
Sbjct: 193 HPGLG-----AAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSP 247

Query: 162 KGPRGSQGGGGGGSSSSSVVSS-----------GGDEGYGTGGGGSSATS--GGRRGSLE 208
            G   S   G   S+ SS  SS            G +    G    SA S   G  GS+ 
Sbjct: 248 LGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSML 307

Query: 209 MSSDGEPLS---RMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCW 265
            +    PL    R  +         D  +   + R  PA         S  +   ++C  
Sbjct: 308 SAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPA-------GASLRRKGLHSCHI 360

Query: 266 DQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGD 325
             C   +  +  L  H+R  H  G+R   FVC W  C    T S     LQRH+ TH+G+
Sbjct: 361 PGCGKVYGKTSHLKAHLRW-HT-GERP--FVCNWLFCGKRFTRSDE---LQRHLRTHTGE 413

Query: 326 KPFKCVVGGCNASFASQGGLARHVPTH 352
           K F C V  CN  F     L++HV TH
Sbjct: 414 KRFACPV--CNKRFMRSDHLSKHVKTH 438



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 42/163 (25%), Positives = 64/163 (39%), Gaps = 17/163 (10%)

Query: 23  GSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETM 82
           GSP  +    ++      +     + + + + A+  + G S    G  G    GG +   
Sbjct: 10  GSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAA 69

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           +  +  +A+ A    D            S S GG   SSA SL  SS  +++      + 
Sbjct: 70  AAAAAAAAAAAALVSD------------SFSCGGSPGSSAFSLTSSSAAAAA-----AAA 112

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGG 185
            AA+SSS   +     + P    GS GGGGGG   SS  S  G
Sbjct: 113 AAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDG 155



 Score = 33.1 bits (74), Expect = 0.63
 Identities = 34/142 (23%), Positives = 49/142 (34%), Gaps = 13/142 (9%)

Query: 85  PSPESASQAGEDEDEEEDDEEEEDESSSSG----GGEEESSAESLVGSSGGSSSDETRSL 140
           PSP S S +     +     +    SSS+     G    S   S    +GGSSS    + 
Sbjct: 14  PSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAA 73

Query: 141 SPGAASS-------SSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD--EGYGT 191
           +  AA++       S G   G            +       ++SSS  ++     +  G 
Sbjct: 74  AAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGV 133

Query: 192 GGGGSSATSGGRRGSLEMSSDG 213
            GG      GG  GS   S DG
Sbjct: 134 SGGSGGGGGGGGGGSSAHSQDG 155



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 14/29 (48%), Positives = 16/29 (55%)

Query: 63  SGGGGGGGGGGVGGGEAETMSEPSPESAS 91
           SGGGGGGG  G G G  +     S  SA+
Sbjct: 439 SGGGGGGGSAGSGSGGKKGSDTDSEHSAA 467


>gi|110431364 GLIS family zinc finger 2 [Homo sapiens]
          Length = 524

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 48/197 (24%), Positives = 80/197 (40%), Gaps = 40/197 (20%)

Query: 195 GSSATSGGRRGSLEM-----SSDGEPLSRMDSEDSISSTIMDVDS-----TISSGRSTPA 244
           GSS+ S  R+G+ ++     +SD +PL  +D   S     + + S       +S   TP 
Sbjct: 94  GSSSLSPERQGNGDLPPVPSASDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLTPP 153

Query: 245 MMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-- 302
                       K +   C W +C   F    DL DH+   HV  ++   + C W+GC  
Sbjct: 154 KDKCLSPDLPLPKQLV--CRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCAR 211

Query: 303 ---------------------KVYNTPSTSQSW-----LQRHMLTHSGDKPFKCVVGGCN 336
                                K +  P+ S+S+     L+ H  +H+G+KP+ C   GCN
Sbjct: 212 HGRGFNARYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCN 271

Query: 337 ASFASQGGLARHVPTHF 353
             +++     +H  TH+
Sbjct: 272 KRYSNSSDRFKHTRTHY 288



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 5/59 (8%)

Query: 261 YNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRH 318
           Y C ++ C   +++S D   H R+ +VD      + C   GC K Y  PS+ +  ++ H
Sbjct: 263 YVCPYEGCNKRYSNSSDRFKHTRTHYVDKP----YYCKMPGCHKRYTDPSSLRKHIKAH 317


>gi|170650685 zinc finger and BTB domain containing 37 isoform a
           [Homo sapiens]
          Length = 503

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 94/324 (29%), Positives = 125/324 (38%), Gaps = 59/324 (18%)

Query: 84  EPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPG 143
           E SP   S + +  +   D E  E     +  G+     E+ V   GG S DE R L  G
Sbjct: 186 ELSPPEESTSPQIIEPSSDVESREPILRINRAGQWY--VETGVADRGGRSDDEVRVL--G 241

Query: 144 AASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVS---------SGGDEGYGTGGG 194
           A    +      E LEE  GP  +Q  G  GSS+  V +         S G E Y  G  
Sbjct: 242 AVHIKT------ENLEEWLGPE-NQPSGEDGSSAEEVTAMVIDTTGHGSVGQENYTLGSS 294

Query: 195 GSSATSGGRRGSLEMSSDGE--PLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQG-- 250
           G+             S  G   PL+      S S   MD     SS     AMM   G  
Sbjct: 295 GAKVARPTSSEVDRFSPSGSVVPLTERHRARSESPGRMDEPKQPSSQVEESAMMGVSGYV 354

Query: 251 ----STTSSSKNIAYN----CCWDQCQACFNSSPDLADHIRSIHVDGQRGGV--FVCLWK 300
                   S +   YN    C +  C   FN    L  H+R +H+     G+  FVC   
Sbjct: 355 EYLREQEVSERWFRYNPRLTCIY--CAKSFNQKGSLDRHMR-LHM-----GITPFVCRMC 406

Query: 301 GCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARH--------VPTH 352
           G K      T +  L+ H+  H+G+KPF C V  C  SF  Q  L +H        +P  
Sbjct: 407 GKKY-----TRKDQLEYHIRKHTGNKPFHCHV--CGKSFPFQAILNQHFRKNHPGCIPLE 459

Query: 353 --FSQQNSSKVSSQPKAKEESPSK 374
              S    + V+S+ +A+EESPS+
Sbjct: 460 GPHSISPETTVTSRGQAEEESPSQ 483


>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
           [Homo sapiens]
          Length = 526

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 57/171 (33%), Positives = 63/171 (36%), Gaps = 54/171 (31%)

Query: 60  NGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEE 119
           N  SGGGGGGGGGG  G                              +D+SS S GG   
Sbjct: 162 NSSSGGGGGGGGGGNYG------------------------------QDQSSMSSGG--- 188

Query: 120 SSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKG-PRGSQGGGGGGSSSS 178
                  GS GG           G    S G G G  G ++  G  RG  GGGGGG    
Sbjct: 189 -------GSGGGY----------GNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGG 231

Query: 179 SVVSSGGDEGYGTGG--GGSSATSGGRRGSL-EMSSDGEPLSRMDSEDSIS 226
              SSGG E  G GG  GG     G  RG   +     +  SR DSE   S
Sbjct: 232 YNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNS 282



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 15/129 (11%)

Query: 61  GGSGGGGGGG---GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGE 117
           GGSGGGG GG   GGG GGG+        P    +        E ++ +  +    GGG 
Sbjct: 400 GGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGP 459

Query: 118 EESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSS 177
             S         GG+  D+ R    G      G   G+ G  +  G RG +GGG  G   
Sbjct: 460 GGS-------HMGGNYGDDRRG---GRGGYDRGGYRGRGG--DRGGFRGGRGGGDRGGFG 507

Query: 178 SSVVSSGGD 186
              + S G+
Sbjct: 508 PGKMDSRGE 516



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 44/177 (24%), Positives = 60/177 (33%), Gaps = 41/177 (23%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEE--SSAESLVGSSGGSSS------ 134
           ++ +P+     G     +        +SS  G G++   SS     GSS  SSS      
Sbjct: 68  TQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQS 127

Query: 135 ----------------DETRSLSP----------GAASSSSGDGDGKEGLEEPKGPRGSQ 168
                            + +S +P           ++S   G G G     + +    S 
Sbjct: 128 GSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSG 187

Query: 169 GGGGGGSSSSSVVSSGGDEGY------GTGGGGSSATSGGRRGSLEMSSDG-EPLSR 218
           GG GGG  +      GG  GY      G G GGS    GG  G    SS G EP  R
Sbjct: 188 GGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR 244



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/207 (27%), Positives = 78/207 (37%), Gaps = 55/207 (26%)

Query: 61  GGSGGGGGGGGGGV------------GGGEAET--MSEPSPESASQAGEDEDEEEDDEEE 106
           GGSGGGGGGGGGG             GGG      M        ++ G   D+    + E
Sbjct: 219 GGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSE 278

Query: 107 EDESSSS-----GGGEE---ESSAESL--VG-------------------SSGGSSSDET 137
           +D S ++     G GE    ES A+    +G                    +G    + T
Sbjct: 279 QDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEAT 338

Query: 138 RSLS-PGAASSSSGDGDGKEGLEEP-------KGPRGSQGGGGG--GSSSSSVVSSGGDE 187
            S   P +A ++    DGKE    P       +    ++GGG G  G      +  GG  
Sbjct: 339 VSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYG 398

Query: 188 GYGTGGGGSSA--TSGGRRGSLEMSSD 212
           G G+GGGG     + GG  G  + + D
Sbjct: 399 GGGSGGGGRGGFPSGGGGGGGQQRAGD 425



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 34/106 (32%), Positives = 43/106 (40%), Gaps = 2/106 (1%)

Query: 114 GGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGG 173
           G G  + S++     S    S  T +   G +S SS       G      P+G    GG 
Sbjct: 22  GQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGY 81

Query: 174 GSSSSSVVSSGGDEGYGTGG--GGSSATSGGRRGSLEMSSDGEPLS 217
           GSS SS  S G    Y   G     S+TSG    S + SS G+P S
Sbjct: 82  GSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQS 127



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 43/161 (26%), Positives = 52/161 (32%), Gaps = 35/161 (21%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEED----DEEEEDESSSSGGG 116
           GG G GG  G GG GGG +         S    G  +    D    +   E+ + S    
Sbjct: 384 GGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE 443

Query: 117 EEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSS 176
             +  A    G  GG          PG +      GD +              GG GG  
Sbjct: 444 CNQCKAPKPDGPGGG----------PGGSHMGGNYGDDRR-------------GGRGGYD 480

Query: 177 SSSVVSSGGDEGYGTGGGGSSATSGGRRGSL---EMSSDGE 214
                  GGD G   GG G     GG RG     +M S GE
Sbjct: 481 RGGYRGRGGDRGGFRGGRG-----GGDRGGFGPGKMDSRGE 516


>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
          Length = 686

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 64/209 (30%), Positives = 82/209 (39%), Gaps = 27/209 (12%)

Query: 22  PGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAET 81
           PG PG AA G AE PE  E  EE    A A   A             GGGG   G EAE 
Sbjct: 28  PGEPG-AAGGEAEGPEGSEGAEEAPRGAAAVKEA-------------GGGGPDRGPEAEA 73

Query: 82  MSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSS-GGSSSDETRSL 140
                  +    GE E EE   E  E       GGEE S A+ + G+S G  +  E R  
Sbjct: 74  RG-----TRGAHGETEAEEGAPEGAEVPQ----GGEETSGAQQVEGASPGRGAQGEPRGE 124

Query: 141 SPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATS 200
           +      S+     +E  + P+ P GS  G  G S  +      GD     G  G S  +
Sbjct: 125 AQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAE--GPLGDNIEAEGPAGDSVEA 182

Query: 201 GGRRGSLEMSSDGEPLSRMDSEDSISSTI 229
            GR G   + ++G     +D+E  +   I
Sbjct: 183 EGRVGD-SVDAEGPAGDSVDAEGPLGDNI 210



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 60/235 (25%), Positives = 84/235 (35%), Gaps = 17/235 (7%)

Query: 12  EELSRLSPLPPGSPGSAA----RGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGG 67
           EE S    +   SPG  A    RG A+   E+    E +EEAE           G  G  
Sbjct: 100 EETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDS 159

Query: 68  GGGGGGVGGG-EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLV 126
               G +G   EAE  +  S E+  + G+  D E    +  D     G   +   AE   
Sbjct: 160 VDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLG---DNIQAEGPA 216

Query: 127 GSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD 186
           G S  +      S+     +  S D +G+ G     G     G   G  +  SV +    
Sbjct: 217 GDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAE--- 273

Query: 187 EGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRS 241
                G  G S  + G  G     S GEP    D   S  +  ++V +  S+GRS
Sbjct: 274 -----GPAGDSMDAEGPAGRARRVS-GEPQQSGDGSLSPQAEAIEVAAGESAGRS 322



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 52/213 (24%), Positives = 75/213 (35%), Gaps = 7/213 (3%)

Query: 21  PPGSPGS--AARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGE 78
           P GS G+  A RG A   E      +   EAEA           +  G   G     GGE
Sbjct: 41  PEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGE 100

Query: 79  AETMSEPSPESAS--QAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDE 136
            ET      E AS  +  + E   E   E ED ++     E E   E   GS+ G + D 
Sbjct: 101 -ETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDS 159

Query: 137 TRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGS 196
             +  P    +   +G   + +E       S    G    S       GD     G  G 
Sbjct: 160 VDAEGP-LGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGD 218

Query: 197 SATSGGRRGSLEMSSDGEPLSRMDSEDSISSTI 229
           S  + GR G   + ++G     +D+E  +  ++
Sbjct: 219 SVDAEGRVGD-SVDAEGPAGDSVDAEGRVGDSV 250



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 44/151 (29%), Positives = 58/151 (38%), Gaps = 24/151 (15%)

Query: 23  GSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETM 82
           G  G A R   EP  ++  +     +AEA  VAA    G S G   G        EAE  
Sbjct: 284 GPAGRARRVSGEP--QQSGDGSLSPQAEAIEVAA----GESAGRSPGELAWDAAEEAEVP 337

Query: 83  SEPSPESAS------QAGEDE-----DEEEDDEEEEDESSSSG-------GGEEESSAES 124
                E A+       AGED       +E  ++EE  E S  G       GGEEES   S
Sbjct: 338 GVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSS 397

Query: 125 LVGSSGGSSSDETRSLSPGAASSSSGDGDGK 155
             G +   +++    LS   A     +G G+
Sbjct: 398 PHGEASRGAAEPEAQLSNHLAEEGPAEGSGE 428



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 60/240 (25%), Positives = 79/240 (32%), Gaps = 63/240 (26%)

Query: 22  PGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAET 81
           P      A GR     + E    +  +AE          G S   G   G GV   EA  
Sbjct: 215 PAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRV-------GDSVEAGDPAGDGV---EAGV 264

Query: 82  MSEPSPESASQAGEDEDEEED---DEEEEDESSSSGGGEEESSAESL---VGSSGGSSSD 135
            +  S E+   AG+  D E           E   SG G     AE++    G S G S  
Sbjct: 265 PAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPG 324

Query: 136 E----------------TRSLSPGAASSSSGD---GDGKE---GLEE------PKGPRGS 167
           E                +   +PG A + +G+   GDG +   G +E      P+GPR  
Sbjct: 325 ELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREE 384

Query: 168 QGGGGGGSSSSSVVSSGGDEGYGTG-----------------GGGSSATSGGRRGSLEMS 210
           +  GG   S  S  S  G+   G                   G G +A   GRR   E S
Sbjct: 385 EAAGGEEESPDS--SPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEAS 442



 Score = 32.7 bits (73), Expect = 0.82
 Identities = 25/107 (23%), Positives = 37/107 (34%), Gaps = 5/107 (4%)

Query: 87  PESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAAS 146
           PE  +   E   E      E +    S G EE     + V  +GG   D           
Sbjct: 18  PEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTR 77

Query: 147 SSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGG 193
            + G+ + +EG      P G++   GG  +S +    G   G G  G
Sbjct: 78  GAHGETEAEEG-----APEGAEVPQGGEETSGAQQVEGASPGRGAQG 119



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 38/138 (27%), Positives = 48/138 (34%), Gaps = 20/138 (14%)

Query: 22  PGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAET 81
           PG     A   AE P  +  EE    +A A+A          G    G G     GE E 
Sbjct: 323 PGELAWDAAEEAEVPGVKGSEEAAPGDARADA----------GEDRVGDGPQQEPGEDEE 372

Query: 82  MSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLS 141
             E SPE          EEE    EE+   SS  GE    A           ++E  +  
Sbjct: 373 RRERSPEGPR-------EEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEG 425

Query: 142 PGAASSSSG---DGDGKE 156
            G A+  +G   DG+  E
Sbjct: 426 SGEAARVNGRREDGEASE 443


>gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein
           [Homo sapiens]
          Length = 593

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 59/208 (28%), Positives = 77/208 (37%), Gaps = 30/208 (14%)

Query: 10  DLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN--------- 60
           +LE   +L P PP +P    R RA P E+ E E    + A+  A+AA+            
Sbjct: 20  ELEARQQLPPDPPAAP--PGRARAAPDEDREPESARMQRAQMAALAAMRAAAAGLGHPAS 77

Query: 61  -GGSGGG---------------GGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDE 104
            GGS  G               G  G G  G GE       S E      E+E+ EED  
Sbjct: 78  PGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLG 137

Query: 105 EEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKE---GLEEP 161
           E+E+E       EEE   E  +G  G +S   T      A    +  GDG     G +E 
Sbjct: 138 EDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQER 197

Query: 162 KGPRGSQGGGGGGSSSSSVVSSGGDEGY 189
            GP  +  GG    +        GD  Y
Sbjct: 198 PGPGPAHPGGAAHVAPQLQPPDHGDWTY 225



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 10/45 (22%)

Query: 167 SQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSS 211
           ++GGGGGG SSS+            G GG++ TSGG+ G   +S+
Sbjct: 548 NKGGGGGGGSSSN----------AGGRGGNTGTSGGQAGPAGLST 582


>gi|118766337 zinc finger protein of the cerebellum 5 [Homo sapiens]
          Length = 663

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 28/89 (31%), Positives = 40/89 (44%)

Query: 268 CQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKP 327
           C   F +  +L +H+   HV G      VC W+ C     P  ++  L  H+  H+G+KP
Sbjct: 431 CSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKP 490

Query: 328 FKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           F C   GC   FA    L  H  TH  ++
Sbjct: 491 FPCPFPGCGKVFARSENLKIHKRTHTGEK 519



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 12/98 (12%)

Query: 263 CCWDQCQA---CFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRH 318
           C W+ C      F +   L +HIR +H  G++   F C + GC KV+         L+ H
Sbjct: 460 CFWEDCPREGKPFKAKYKLINHIR-VHT-GEKP--FPCPFPGCGKVFARSEN----LKIH 511

Query: 319 MLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
             TH+G+KPFKC   GC+  FA+     +H   H S +
Sbjct: 512 KRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDK 549



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 7/92 (7%)

Query: 261 YNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHML 320
           + C +  C   F  S +L  H R+ H  G++   F C + GC   +    + S  ++H  
Sbjct: 491 FPCPFPGCGKVFARSENLKIHKRT-HT-GEKP--FKCEFDGC---DRKFANSSDRKKHSH 543

Query: 321 THSGDKPFKCVVGGCNASFASQGGLARHVPTH 352
            H+ DKP+ C + GC+ S+     L +H+  H
Sbjct: 544 VHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIH 575



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 38/178 (21%), Positives = 53/178 (29%), Gaps = 10/178 (5%)

Query: 18  SPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGG 77
           +PL P     A+     PP +      E   A A A A +   G      GGG  G    
Sbjct: 89  TPLGPEHMAQASTLGLSPPSQAFPAHPEAPAAAARAAALVAHPGAGSYPCGGGSSGAQPS 148

Query: 78  EAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDET 137
                + P P + S                  ++S GGG           S  G S D  
Sbjct: 149 APPPPAPPLPPTPSPPPPPPPPPPPALSGYTTTNSGGGG----------SSGKGHSRDFV 198

Query: 138 RSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGG 195
                 A + ++       G E+  G    Q       S+   +S+ G      G GG
Sbjct: 199 LRRDLSATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGMFISASGTYAGPDGSGG 256


>gi|22547197 zinc finger protein of the cerebellum 2 [Homo sapiens]
          Length = 532

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 28/89 (31%), Positives = 40/89 (44%)

Query: 268 CQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKP 327
           C   F++  +L  H+   HV G      VC W+ C     P  ++  L  H+  H+G+KP
Sbjct: 273 CNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKP 332

Query: 328 FKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           F C   GC   FA    L  H  TH  ++
Sbjct: 333 FPCPFPGCGKVFARSENLKIHKRTHTGEK 361



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 34/105 (32%), Positives = 45/105 (42%), Gaps = 2/105 (1%)

Query: 101 EDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEE 160
           E   +  + S ++  G E S+   LV  S    S    +LSP AA++++        +  
Sbjct: 416 ESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSS--NLSPAAAAAAAAAAAAAAAVSA 473

Query: 161 PKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRG 205
                GS  GG GG S     S GG  G G GGGGSS    G  G
Sbjct: 474 VHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAG 518



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 12/98 (12%)

Query: 263 CCWDQCQA---CFNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRH 318
           C W++C      F +   L +HIR +H  G++   F C + GC KV+         L+ H
Sbjct: 302 CFWEECPREGKPFKAKYKLVNHIR-VHT-GEKP--FPCPFPGCGKVFARSEN----LKIH 353

Query: 319 MLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ 356
             TH+G+KPF+C   GC+  FA+     +H+  H S +
Sbjct: 354 KRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDK 391



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 32/117 (27%), Positives = 55/117 (47%), Gaps = 9/117 (7%)

Query: 261 YNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHML 320
           + C +  C   F  S +L  H R+ H  G++   F C ++GC      S+ +   ++HM 
Sbjct: 333 FPCPFPGCGKVFARSENLKIHKRT-HT-GEKP--FQCEFEGCDRRFANSSDR---KKHMH 385

Query: 321 THSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGM 377
            H+ DKP+ C +  C+ S+     L +H+  H S    S+ S    +  ES +  G+
Sbjct: 386 VHTSDKPYLCKM--CDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGL 440



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 5/106 (4%)

Query: 83  SEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSP 142
           SE SP ++S               E +SSS+      S A +   ++  +++    ++  
Sbjct: 422 SESSPAASSGYESSTPPGLVSPSAEPQSSSN-----LSPAAAAAAAAAAAAAAAVSAVHR 476

Query: 143 GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEG 188
           G  S S G G G  G     G  G  GGGGGGSS     ++GG  G
Sbjct: 477 GGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSG 522



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 30/116 (25%), Positives = 44/116 (37%), Gaps = 7/116 (6%)

Query: 76  GGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGS--SGGSS 133
           G E+   +    ES++  G      E         +++      ++A + V +   GG S
Sbjct: 421 GSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGS 480

Query: 134 SDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGY 189
                    G  S S G G G  G     G  GS GGG G +   S +SS  +E Y
Sbjct: 481 GSGGAGGGSGGGSGSGGGGGGAGG-----GGGGSSGGGSGTAGGHSGLSSNFNEWY 531



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 17/29 (58%), Positives = 19/29 (65%)

Query: 49  AEAEAVAALLLNGGSGGGGGGGGGGVGGG 77
           A A AV+A+   GGSG GG GGG G G G
Sbjct: 466 AAAAAVSAVHRGGGSGSGGAGGGSGGGSG 494



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 14/17 (82%), Positives = 14/17 (82%)

Query: 61  GGSGGGGGGGGGGVGGG 77
           GGSG GGGGGG G GGG
Sbjct: 491 GGSGSGGGGGGAGGGGG 507



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 14/22 (63%), Positives = 16/22 (72%)

Query: 60  NGGSGGGGGGGGGGVGGGEAET 81
           +GG GGG GGGGGG  GG + T
Sbjct: 495 SGGGGGGAGGGGGGSSGGGSGT 516



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 29/93 (31%), Positives = 35/93 (37%), Gaps = 20/93 (21%)

Query: 18  SPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLN--------------GGS 63
           S  PPG    +A    EP             A A A AA  ++              GGS
Sbjct: 434 SSTPPGLVSPSA----EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGS 489

Query: 64  GGG--GGGGGGGVGGGEAETMSEPSPESASQAG 94
           GGG   GGGGGG GGG   +    S  +   +G
Sbjct: 490 GGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSG 522


>gi|186928827 dermokine isoform 5 precursor [Homo sapiens]
          Length = 398

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 44/154 (28%), Positives = 58/154 (37%), Gaps = 25/154 (16%)

Query: 62  GSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESS 121
           GSGGG    GGG G          S   +S +G + D           S SS GG    S
Sbjct: 236 GSGGGSSNSGGGSG----------SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGS 285

Query: 122 AESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVV 181
           +    G+SGGS  D     S G+++ SS                G+ GG GGG+      
Sbjct: 286 SGGSSGNSGGSRGDSGSESSWGSSTGSSS---------------GNHGGSGGGNGHKPGC 330

Query: 182 SSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEP 215
              G+E  G+G  G     G    S   +S+  P
Sbjct: 331 EKPGNEARGSGESGIQGFRGQGVSSNMRNSETSP 364



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 46/148 (31%), Positives = 60/148 (40%), Gaps = 19/148 (12%)

Query: 62  GSGGGGGGGGG--GVGGGEAETMSEPSPESASQAGEDED-EEEDDEEEEDESSSSGGGEE 118
           G+  G GG GG    G      +++P   S   + ++E             SS+SGGG  
Sbjct: 190 GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249

Query: 119 ESSAESLVGSSG-GSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSS 177
             S     GSSG GS+ D     S G +SS S  G          G  G   GG  G+S 
Sbjct: 250 SQS-----GSSGSGSNGDNNNGSSSGGSSSGSSSG----------GSSGGSSGGSSGNSG 294

Query: 178 SSVVSSGGDEGYGTGGGGSSATSGGRRG 205
            S   SG +  +G+  G SS   GG  G
Sbjct: 295 GSRGDSGSESSWGSSTGSSSGNHGGSGG 322



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 53/177 (29%), Positives = 69/177 (38%), Gaps = 23/177 (12%)

Query: 64  GGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAE 123
           G GG GG    G      +++P   S   + ++E             SS+ GG   S + 
Sbjct: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS- 252

Query: 124 SLVGSSG-GSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSS----- 177
              GSSG GS+ D     S G +SS S  G    G     G  G+ GG  G S S     
Sbjct: 253 ---GSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGG--SSGGSSGNSGGSRGDSGSESSWG 307

Query: 178 SSVVSSGGDEGYGTGGG----------GSSATSGGRRGSLEMSSDGEPLSRMDSEDS 224
           SS  SS G+ G G+GGG          G+ A   G  G       G   +  +SE S
Sbjct: 308 SSTGSSSGNHG-GSGGGNGHKPGCEKPGNEARGSGESGIQGFRGQGVSSNMRNSETS 363



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 45/155 (29%), Positives = 61/155 (39%), Gaps = 18/155 (11%)

Query: 61  GGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEES 120
           G  GG GG G G  GG     +      SA   G +       +       + G   + +
Sbjct: 152 GSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGA 211

Query: 121 SAESLVGSSGGSSSDETRSLSP----GAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSS 176
            A+   GS   S+ +E  +  P    G  SS+SG G G +         GS G G  G +
Sbjct: 212 VAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS--------GSSGSGSNGDN 263

Query: 177 SSSVVSSGGDEGYGTGG------GGSSATSGGRRG 205
           ++   S G   G  +GG      GGSS  SGG RG
Sbjct: 264 NNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 42/167 (25%), Positives = 61/167 (36%), Gaps = 27/167 (16%)

Query: 115 GGEEESSAESLVGSSGGSSSDETRSLSPGAASSS-----SGDGDGKEGLEEPKGPRGSQG 169
           G  E S    + GS GG       +  PG   +       G+  G  G+     P G  G
Sbjct: 140 GAWETSGGHGIFGSQGGLGGQGQGN--PGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGG 197

Query: 170 GGGGGSSSSSVVSSGGDEGYGT-----------------GGGGSSATSGG---RRGSLEM 209
            GG  +  ++   +    GYG+                  GGGSS + GG   + GS   
Sbjct: 198 NGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGS 257

Query: 210 SSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSS 256
            S+G+  +   S  S S +     S  SSG S+      +G + S S
Sbjct: 258 GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSES 304



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 39/128 (30%), Positives = 44/128 (34%), Gaps = 45/128 (35%)

Query: 60  NGGSGGGGGGG---GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGG 116
           NG S GG   G   GG  GG                                 S +SGG 
Sbjct: 265 NGSSSGGSSSGSSSGGSSGGSSG----------------------------GSSGNSGGS 296

Query: 117 EEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEP------KGPRGSQGG 170
             +S +ES  GSS GSSS        G    S G    K G E+P       G  G QG 
Sbjct: 297 RGDSGSESSWGSSTGSSS--------GNHGGSGGGNGHKPGCEKPGNEARGSGESGIQGF 348

Query: 171 GGGGSSSS 178
            G G SS+
Sbjct: 349 RGQGVSSN 356



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 14/105 (13%)

Query: 134 SDETRSLSPGAASSSSGDGDGK-----EGLEEPKGPR-GSQGGGGGGSSSSSVVSSGGDE 187
           S E   L  G  S+ +  G+       + L E  G   G + GG  GS  S  +  G  E
Sbjct: 18  SGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTRE 77

Query: 188 GYGTG-----GGGSSATSGGRRGSL--EMSSDGEPLSRMDSEDSI 225
             GTG     G G++   G R G     + + G  + R  +ED I
Sbjct: 78  AVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR-QAEDVI 121


>gi|22547201 zinc finger protein of the cerebellum 4 [Homo sapiens]
          Length = 334

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 27/89 (30%), Positives = 40/89 (44%)

Query: 268 CQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKP 327
           C   F++  +L  H+   HV G      +C W+ C     P  ++  L  H+  H+G+KP
Sbjct: 144 CSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKP 203

Query: 328 FKCVVGGCNASFASQGGLARHVPTHFSQQ 356
           F C   GC   FA    L  H  TH  ++
Sbjct: 204 FPCPFPGCGKVFARSENLKIHKRTHTGEK 232



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/149 (28%), Positives = 66/149 (44%), Gaps = 20/149 (13%)

Query: 263 CCWDQCQAC---FNSSPDLADHIRSIHVDGQRGGVFVCLWKGC-KVYNTPSTSQSWLQRH 318
           C W++C      F +   L +HIR +H  G++   F C + GC KV+         L+ H
Sbjct: 173 CFWEECPRQGKPFKAKYKLVNHIR-VHT-GEKP--FPCPFPGCGKVFARSEN----LKIH 224

Query: 319 MLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQ-NSSKVSSQPKAKEESPSKAGM 377
             TH+G+KPF+C   GC   FA+     +H   H S +  + KV    K      S   +
Sbjct: 225 KRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSS---L 281

Query: 378 NKRRKLKNKRRRSLPRPHDFFDAQTLDAI 406
            K  K+  +     P P   +D+ T  A+
Sbjct: 282 RKHMKVHGRS----PPPSSGYDSATPSAL 306


>gi|167466187 integrin-binding sialoprotein precursor [Homo sapiens]
          Length = 317

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 49/182 (26%), Positives = 76/182 (41%), Gaps = 24/182 (13%)

Query: 23  GSPGSAARGRAEPPEEEEEEEE------------EEEEAEAEAVAALLLNGGSGGGGGGG 70
           GS  S+     +  EEEEEEEE            E+E++EAE         G G     G
Sbjct: 62  GSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGEDATPG 121

Query: 71  GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSG 130
            G  G    +   +    +     E E +EE++EEEE   +     E + + + + G+S 
Sbjct: 122 TGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTST 181

Query: 131 GSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQ-----GGGGGGSSSSSVVSSGG 185
            S+  E         + SSG  +G+EG EE      ++     G  G G+S ++   +GG
Sbjct: 182 NSTEAEN-------GNGSSGGDNGEEGEEESVTGANAEDTTETGRQGKGTSKTTTSPNGG 234

Query: 186 DE 187
            E
Sbjct: 235 FE 236



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 36/139 (25%), Positives = 55/139 (39%), Gaps = 11/139 (7%)

Query: 19  PLPPGSPGSAARGRAEPPEEEEEEEE--EEEEAEAEAVAALLLNGGSGGGGGGGGGGVGG 76
           P   G   + A    E  EEEEEEEE  E EE+EAE               G  G     
Sbjct: 133 PKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEV---------DENEQGINGTSTNS 183

Query: 77  GEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDE 136
            EAE  +  S     + GE+E     + E+  E+   G G  +++     G    +    
Sbjct: 184 TEAENGNGSSGGDNGEEGEEESVTGANAEDTTETGRQGKGTSKTTTSPNGGFEPTTPPQV 243

Query: 137 TRSLSPGAASSSSGDGDGK 155
            R+ SP    +++ + +G+
Sbjct: 244 YRTTSPPFGKTTTVEYEGE 262



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 41/185 (22%), Positives = 73/185 (39%), Gaps = 27/185 (14%)

Query: 85  PSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAE--------SLVGSSGGSSSDE 136
           P   S+  + E+ D+  ++EEEE+E+S+ G   EES+ +        +L  ++ G   D 
Sbjct: 59  PVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGEDA 118

Query: 137 T-----RSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGY-G 190
           T       L+       +GD   K   E+       +   G  +  S       ++G  G
Sbjct: 119 TPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGING 178

Query: 191 TGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQG 250
           T    + A +G      +   +GE       E+S++    + + T  +GR       G  
Sbjct: 179 TSTNSTEAENGNGSSGGDNGEEGE-------EESVTGA--NAEDTTETGRQG----KGTS 225

Query: 251 STTSS 255
            TT+S
Sbjct: 226 KTTTS 230


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.127    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,338,375
Number of Sequences: 37866
Number of extensions: 1468096
Number of successful extensions: 67767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1777
Number of HSP's successfully gapped in prelim test: 1438
Number of HSP's that attempted gapping in prelim test: 15778
Number of HSP's gapped (non-prelim): 25690
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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