Search of human proteins with 166795247

Search of human proteins with 166795247

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3
(p55, gamma) [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5...   952   0.0  
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5...   952   0.0  
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp...   723   0.0  
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp...   687   0.0  
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp...   682   0.0  
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta...   650   0.0  
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]    62   8e-10
gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                   61   2e-09
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...    60   3e-09
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    60   3e-09
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]           59   7e-09
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]          59   9e-09
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]             57   4e-08
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]            57   4e-08
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           56   6e-08
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]          55   1e-07
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]          55   1e-07
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...    55   2e-07
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...    55   2e-07
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...    55   2e-07
gi|195976771 cytokine-inducible SH2-containing protein isoform 1...    54   3e-07
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ...    54   3e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    53   7e-07
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     52   1e-06
gi|4503787 fyn-related kinase [Homo sapiens]                           52   1e-06
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    52   1e-06
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    52   1e-06
gi|111074524 Src homology 2 domain containing F [Homo sapiens]         52   1e-06
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    51   2e-06
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]       51   2e-06

>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
           gamma) [Homo sapiens]
          Length = 461

 Score =  952 bits (2462), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 60
           MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL
Sbjct: 1   MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 60

Query: 61  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 120
           QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
Sbjct: 61  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 120

Query: 121 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 180
           KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
Sbjct: 121 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 180

Query: 181 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240
           LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
Sbjct: 181 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240

Query: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 300
           IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP
Sbjct: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 300

Query: 301 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 360
           DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV
Sbjct: 301 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 360

Query: 361 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 420
           EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
Sbjct: 361 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 420

Query: 421 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461
           LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
Sbjct: 421 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461


>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
           gamma) [Homo sapiens]
          Length = 461

 Score =  952 bits (2462), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 60
           MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL
Sbjct: 1   MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 60

Query: 61  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 120
           QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
Sbjct: 61  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 120

Query: 121 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 180
           KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
Sbjct: 121 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 180

Query: 181 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240
           LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
Sbjct: 181 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240

Query: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 300
           IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP
Sbjct: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 300

Query: 301 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 360
           DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV
Sbjct: 301 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 360

Query: 361 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 420
           EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
Sbjct: 361 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 420

Query: 421 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461
           LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
Sbjct: 421 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461


>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
           isoform 2 [Homo sapiens]
          Length = 454

 Score =  723 bits (1867), Expect = 0.0
 Identities = 355/455 (78%), Positives = 404/455 (88%), Gaps = 4/455 (0%)

Query: 1   MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 60
           MYNTVW+M+  D ++ +  +   T+L+FYIEMDPPALPPKPPKP T A  NGM ++++SL
Sbjct: 1   MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTVA-NNGM-NNNMSL 58

Query: 61  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 120
           QDAEWYWGDISREEVN+KLRD  DGTFLVRDASTKM GDYTLTLRKGGNNKLIKI+HRDG
Sbjct: 59  QDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDG 118

Query: 121 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 180
           KYGFSDPLTF+SVVELINHY +ESLAQYNPKLDVKL+YPVS+YQQDQ+VKEDNI+AVGKK
Sbjct: 119 KYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKK 178

Query: 181 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240
           L EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQC TQE++SKEY
Sbjct: 179 LHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEY 238

Query: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 300
           IE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+ RLE+DLK QA + REIDK+MNSIKP
Sbjct: 239 IEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKP 298

Query: 301 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 360
           DLIQLRK RDQ+L+WL  KGVRQK+LN WLG  NE+ ++ Y + E+DE+LPH+DEKTW V
Sbjct: 299 DLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NENTEDQYSLVEDDEDLPHHDEKTWNV 356

Query: 361 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 420
              NR +AE+LL GK DG FL+RESSK+GCYACSVV DGEVKHCVI  TA GYGFAEPYN
Sbjct: 357 GSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYN 416

Query: 421 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
           LYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+AQ
Sbjct: 417 LYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ 451



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           W  G  +R +  + LR   DGTFLVR++S   QG Y  ++   G  K   I      YGF
Sbjct: 354 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 411

Query: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
           ++P   ++S+ EL+ HY H SL Q+N  L+V L YPV   Q+
Sbjct: 412 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 453


>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
           isoform 1 [Homo sapiens]
          Length = 724

 Score =  687 bits (1772), Expect = 0.0
 Identities = 338/421 (80%), Positives = 379/421 (90%), Gaps = 4/421 (0%)

Query: 35  PALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDAST 94
           PALPPKPPKP T A  NGM ++++SLQDAEWYWGDISREEVN+KLRD  DGTFLVRDAST
Sbjct: 305 PALPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 362

Query: 95  KMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDV 154
           KM GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDV
Sbjct: 363 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 422

Query: 155 KLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRT 214
           KL+YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRT
Sbjct: 423 KLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRT 482

Query: 215 AIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSK 274
           AIEAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+
Sbjct: 483 AIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSR 542

Query: 275 MRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKN 334
            RLE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL  KGVRQK+LN WLG  N
Sbjct: 543 RRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--N 600

Query: 335 EDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACS 394
           E+ ++ Y + E+DE+LPH+DEKTW V   NR +AE+LL GK DG FL+RESSK+GCYACS
Sbjct: 601 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 660

Query: 395 VVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHA 454
           VV DGEVKHCVI  TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+A
Sbjct: 661 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720

Query: 455 Q 455
           Q
Sbjct: 721 Q 721



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           W  G  +R +  + LR   DGTFLVR++S   QG Y  ++   G  K   I      YGF
Sbjct: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 681

Query: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
           ++P   ++S+ EL+ HY H SL Q+N  L+V L YPV   Q+
Sbjct: 682 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 723


>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
           isoform 3 [Homo sapiens]
          Length = 424

 Score =  682 bits (1761), Expect = 0.0
 Identities = 336/419 (80%), Positives = 377/419 (89%), Gaps = 4/419 (0%)

Query: 37  LPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKM 96
           LPPKPPKP T A  NGM ++++SLQDAEWYWGDISREEVN+KLRD  DGTFLVRDASTKM
Sbjct: 7   LPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM 64

Query: 97  QGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKL 156
            GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDVKL
Sbjct: 65  HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL 124

Query: 157 MYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAI 216
           +YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRTAI
Sbjct: 125 LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI 184

Query: 217 EAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMR 276
           EAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+ R
Sbjct: 185 EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR 244

Query: 277 LEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNED 336
           LE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL  KGVRQK+LN WLG  NE+
Sbjct: 245 LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NEN 302

Query: 337 ADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVV 396
            ++ Y + E+DE+LPH+DEKTW V   NR +AE+LL GK DG FL+RESSK+GCYACSVV
Sbjct: 303 TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVV 362

Query: 397 ADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
            DGEVKHCVI  TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+AQ
Sbjct: 363 VDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ 421



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           W  G  +R +  + LR   DGTFLVR++S   QG Y  ++   G  K   I      YGF
Sbjct: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 381

Query: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
           ++P   ++S+ EL+ HY H SL Q+N  L+V L YPV   Q+
Sbjct: 382 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423


>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
           [Homo sapiens]
          Length = 728

 Score =  650 bits (1678), Expect = 0.0
 Identities = 311/429 (72%), Positives = 372/429 (86%), Gaps = 5/429 (1%)

Query: 31  EMDPPALPPKPPK--PMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFL 88
           E+ PPALPPKPPK  P  + + NG   S  SLQDAEWYWGDISREEVN+KLRD PDGTFL
Sbjct: 296 EVAPPALPPKPPKAKPAPTVLANG--GSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFL 353

Query: 89  VRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQY 148
           VRDAS+K+QG+YTLTLRKGGNNKLIK++HRDG YGFS+PLTF SVV+LINHY HESLAQY
Sbjct: 354 VRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQY 413

Query: 149 NPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQE 208
           N KLD +L+YPVS+YQQDQ+VKED+++AVG +L+ YH QYQ+KS+EYD+LYEEYTRTSQE
Sbjct: 414 NAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQE 473

Query: 209 IQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLG 268
           +QMKRTAIEAFNETIKIFEEQ  TQE+ SKEY+ERFRREGNEKE++RI++N ++LKSR+ 
Sbjct: 474 LQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIA 533

Query: 269 EIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNV 328
           EIH+S+ +LEQ L+ QA DNREIDK+MNS+KPDL+QLRKIRDQ+LVWL  KG RQK++N 
Sbjct: 534 EIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINE 593

Query: 329 WLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
           WLGIKNE  D+ Y + E++++LPH++E+TW+V  INR QAE++L GK DG FLIRESS++
Sbjct: 594 WLGIKNETEDQ-YALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQR 652

Query: 389 GCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRL 448
           GCYACSVV DG+ KHCVIY TA G+GFAEPYNLY SLKELVLHYQ  SLVQHND+L V L
Sbjct: 653 GCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTL 712

Query: 449 AYPVHAQMP 457
           A+PV A  P
Sbjct: 713 AHPVRAPGP 721


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 41/138 (29%), Positives = 72/138 (52%), Gaps = 19/138 (13%)

Query: 329 WLGIKNEDADENY----FINEEDENLPHYDEKTWFVEDINRVQAEDLLYGK-PDGAFLIR 383
           W   ++++  E Y    ++ E ++++  Y+   W+ + + R QAE LL  +  +G F++R
Sbjct: 251 WWRARDKNGQEGYIPSNYVTEAEDSIEMYE---WYSKHMTRSQAEQLLKQEGKEGGFIVR 307

Query: 384 ESSKKGCYACSVVA------DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSL 437
           +SSK G Y  SV A       G ++H V+ ST +   +    +L+S++ EL+ ++Q  S 
Sbjct: 308 DSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSA 367

Query: 438 VQHNDSLNVRLAYPVHAQ 455
                 L  RL YPV  Q
Sbjct: 368 -----GLISRLKYPVSQQ 380



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 33/124 (26%), Positives = 63/124 (50%), Gaps = 15/124 (12%)

Query: 51  NGMKDSSVSLQDAEWYWGDISREEVNDKLR-DMPDGTFLVRDASTKMQGDYTLTL---RK 106
           N + ++  S++  EWY   ++R +    L+ +  +G F+VRD+S    G YT+++     
Sbjct: 267 NYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKA--GKYTVSVFAKST 324

Query: 107 GGNNKLIKIY----HRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSR 162
           G    +I+ Y        +Y  ++   F+++ ELIN++ H S       L  +L YPVS+
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAG-----LISRLKYPVSQ 379

Query: 163 YQQD 166
             ++
Sbjct: 380 QNKN 383


>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 40/107 (37%), Positives = 59/107 (55%), Gaps = 8/107 (7%)

Query: 351 PHYDEKTWFVEDINRVQAEDLLYGKP-DGAFLIRESSKKGCYACSVVADGEVKHCVIYST 409
           PH + K W+ + ++R +AED+L   P DGAFLIR+      YA +  A G+VKHC I   
Sbjct: 640 PH-ESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRD 698

Query: 410 ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQM 456
            R +        + SL ELV +Y++ SL +      +RL YPV  ++
Sbjct: 699 GRHFVLGTS-AYFESLVELVSYYEKHSLYR-----KMRLRYPVTPEL 739



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 31/184 (16%)

Query: 45  MTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMP-DGTFLVRDASTKMQG--DYT 101
           +T  VPN     S       WY+  +SR E  D L  +P DG FL+R    K +G   Y 
Sbjct: 631 LTDPVPNPNPHES-----KPWYYDSLSRGEAEDMLMRIPRDGAFLIR----KREGSDSYA 681

Query: 102 LTLRKGGNNKLIKIYHRDGK-YGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPV 160
           +T R  G  K  +I +RDG+ +       F S+VEL+++Y   SL +      ++L YPV
Sbjct: 682 ITFRARGKVKHCRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYR-----KMRLRYPV 735

Query: 161 SRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKS--------KEYDRLYEEYTRTSQEIQMK 212
           +     +L++  N++     L +    Y + S        +    LY+   + S E+   
Sbjct: 736 T----PELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFC 791

Query: 213 RTAI 216
           R A+
Sbjct: 792 RGAL 795



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 74/269 (27%), Positives = 117/269 (43%), Gaps = 45/269 (16%)

Query: 198 LYEEYTRTS--------QEIQMKRTAIEAFNETIKIFEEQCHTQEQH--SKEYIERFRRE 247
           +Y  +TRT+        Q I+       +F   + I EE C  ++Q   +K + E F   
Sbjct: 370 IYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSI-EEHCSVEQQRHMAKAFKEVF--- 425

Query: 248 GNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNR-EIDKKMNSIKPDLIQLR 306
           G+    +    + D+L S       S++R +  +K++ L  R ++D  M   K +     
Sbjct: 426 GDLLLTKPTEASADQLPS------PSQLREKIIIKHKKLGPRGDVDVNMEDKKDE----H 475

Query: 307 KIRDQHLVW--LNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLP----HYDEKTWFV 360
           K + +  +W  ++ K  R         +   D  E     E  +++P    H+ EK WF 
Sbjct: 476 KQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEK-WFH 534

Query: 361 EDIN-RVQAEDLLY------GKPDGAFLIRESSK-KGCYACSVVADGEVKHCVIYSTARG 412
           + +  R  AE LL       G  DG FL+RES      Y  S    G V+HC I ST  G
Sbjct: 535 KKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEG 594

Query: 413 YGFAEPY---NL-YSSLKELVLHYQQTSL 437
            G  + Y   NL +SS+  L+ HY++T L
Sbjct: 595 -GTLKYYLTDNLTFSSIYALIQHYRETHL 622



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/66 (40%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 84  DGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHR-DG---KYGFSDPLTFNSVVELINH 139
           DGTFLVR++ T    DYTL+  + G  +  +I    +G   KY  +D LTF+S+  LI H
Sbjct: 558 DGTFLVRESET-FPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQH 616

Query: 140 YHHESL 145
           Y    L
Sbjct: 617 YRETHL 622


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 1/95 (1%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           WY G + R +   +L +  + T+LVR   TK  G+Y ++++     K IKI  RDG +  
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHR-TKESGEYAISIKYNNEAKHIKILTRDGFFHI 170

Query: 125 SDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYP 159
           ++   F S++EL+ +Y H SL +    LD  L +P
Sbjct: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 31/100 (31%), Positives = 51/100 (51%), Gaps = 2/100 (2%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK-GCYACSVVADGEVKHCVIYSTAR 411
           Y  + W+   + R+QAE  L  + +  +L+R  +K+ G YA S+  + E KH  I  T  
Sbjct: 107 YSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRD 165

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP 451
           G+        + SL ELV +Y+  SL +   +L+  L +P
Sbjct: 166 GFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 1/95 (1%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           WY G + R +   +L +  + T+LVR   TK  G+Y ++++     K IKI  RDG +  
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHR-TKESGEYAISIKYNNEAKHIKILTRDGFFHI 730

Query: 125 SDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYP 159
           ++   F S++EL+ +Y H SL +    LD  L +P
Sbjct: 731 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 31/100 (31%), Positives = 51/100 (51%), Gaps = 2/100 (2%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK-GCYACSVVADGEVKHCVIYSTAR 411
           Y  + W+   + R+QAE  L  + +  +L+R  +K+ G YA S+  + E KH  I  T  
Sbjct: 667 YSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRD 725

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP 451
           G+        + SL ELV +Y+  SL +   +L+  L +P
Sbjct: 726 GFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765


>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
          Length = 198

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 16/108 (14%)

Query: 42  PKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYT 101
           P P  + +   +++    L    WYWG ++  E  +KL++ P+GTFL+RD+S     DY 
Sbjct: 29  PSPQAARLAKALRE----LGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYL 81

Query: 102 LTL--RKGGNNKLIKIYHRDGKYGFSDPL-------TFNSVVELINHY 140
           LT+  +       ++I ++DGK+     +        F+SVV LI++Y
Sbjct: 82  LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129


>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
          Length = 535

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 39/114 (34%), Positives = 57/114 (50%), Gaps = 14/114 (12%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           WYWG I+R E   KL ++PDG+FLVRD+S   +   +L+ R  G     +I H +G++ F
Sbjct: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDD-RYLLSLSFRSHGKTLHTRIEHSNGRFSF 442

Query: 125 ---SDPLTFNSVVELINH----------YHHESLAQYNPKLDVKLMYPVSRYQQ 165
               D     S+V+LI H           +  S    +    V+L  PVSR+ Q
Sbjct: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496



 Score = 35.8 bits (81), Expect = 0.084
 Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 3/87 (3%)

Query: 348 ENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESS-KKGCYACSVVADGEVKHCVI 406
           E L    ++ W+   I R +AE  L   PDG+FL+R+SS  +   + S  + G+  H  I
Sbjct: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433

Query: 407 YSTARGYGFAEPYNL--YSSLKELVLH 431
             +   + F E  ++  ++S+ +L+ H
Sbjct: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 41/117 (35%), Positives = 63/117 (53%), Gaps = 17/117 (14%)

Query: 344 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGK-PDGAFLIRESSKKGCYACSVVA----- 397
           +EE+ENL  YD   WF  +I+R Q+E LL  K  +GAF++R SS+ G Y  S+ +     
Sbjct: 285 SEEEENLDDYD---WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVND 341

Query: 398 -DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDS-LNVRLAYPV 452
             G VKH  +++ A    +      + S+ +L+ HY      QHN + +  RL +PV
Sbjct: 342 KKGTVKHYHVHTNAENKLYLAENYCFDSIPKLI-HYH-----QHNSAGMITRLRHPV 392



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 15/111 (13%)

Query: 59  SLQDAEWYWGDISREEVNDKLRDM-PDGTFLVRDASTKMQGDYTLTL-RKGGNNK--LIK 114
           +L D +W+ G+ISR +    LR    +G F+VR++S    G YT++L  K  N+K   +K
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSS--QVGMYTVSLFSKAVNDKKGTVK 347

Query: 115 IYH----RDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVS 161
            YH     + K   ++   F+S+ +LI+++ H S       +  +L +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAG-----MITRLRHPVS 393


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 41/117 (35%), Positives = 63/117 (53%), Gaps = 17/117 (14%)

Query: 344 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGK-PDGAFLIRESSKKGCYACSVVA----- 397
           +EE+ENL  YD   WF  +I+R Q+E LL  K  +GAF++R SS+ G Y  S+ +     
Sbjct: 285 SEEEENLDDYD---WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVND 341

Query: 398 -DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDS-LNVRLAYPV 452
             G VKH  +++ A    +      + S+ +L+ HY      QHN + +  RL +PV
Sbjct: 342 KKGTVKHYHVHTNAENKLYLAENYCFDSIPKLI-HYH-----QHNSAGMITRLRHPV 392



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 15/111 (13%)

Query: 59  SLQDAEWYWGDISREEVNDKLRDM-PDGTFLVRDASTKMQGDYTLTL-RKGGNNK--LIK 114
           +L D +W+ G+ISR +    LR    +G F+VR++S    G YT++L  K  N+K   +K
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSS--QVGMYTVSLFSKAVNDKKGTVK 347

Query: 115 IYH----RDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVS 161
            YH     + K   ++   F+S+ +LI+++ H S       +  +L +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAG-----MITRLRHPVS 393


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 41/171 (23%), Positives = 87/171 (50%), Gaps = 5/171 (2%)

Query: 151 KLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEY---DRLYEEYTRTSQ 207
           KL   L     + Q+ +  KE+   A+ +  QE   +  E S+E+   ++L +E  +   
Sbjct: 171 KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230

Query: 208 EIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRL 267
           ++  ++T I+A  + ++  +E+    EQ  KE  ++   E   KE+E+  M   KL+   
Sbjct: 231 DMDSRQTEIKALQQYVQKSKEELQKLEQQLKE--QKILNERAAKELEQFQMRNAKLQQEN 288

Query: 268 GEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNH 318
            +      +L Q+ + +AL+ +  +++++ ++ D+ +L KIR+Q    L+H
Sbjct: 289 EQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHH 339



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 35/166 (21%), Positives = 75/166 (45%), Gaps = 18/166 (10%)

Query: 189 QEKSKEYDRLYEEYTR--------TSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 240
           +E +KE D+L  E  +        T Q+ + +R+  EA +   +  +E    Q + S+E+
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215

Query: 241 IERFRREGNEKEIERIMMNYDKLKSRLGEIH-------DSKMRLEQDLKNQALDNREIDK 293
               ++E  EKE+++I  + D  ++ +  +        +   +LEQ LK Q + N    K
Sbjct: 216 R---KKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAK 272

Query: 294 KMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADE 339
           ++   +    +L++  +QH +         ++  + L  K E+  +
Sbjct: 273 ELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQ 318



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 29/169 (17%), Positives = 75/169 (44%), Gaps = 28/169 (16%)

Query: 163 YQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNET 222
           Y ++ +  +D I  + +KL+    Q  E  ++         +    + +++  IE   ET
Sbjct: 501 YSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVK----LHLEQQRIEKEKET 556

Query: 223 IKIFEEQCHTQEQHSKEYIERFRRE----------------GNEKEIERIMMNYDKLKSR 266
           +K   ++   Q   +K +IE+   E                  +KE+++++   D L S+
Sbjct: 557 LKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQ 616

Query: 267 LGEIHD------SKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIR 309
           L   +D       K++++Q + N+     + ++++  ++   ++++K+R
Sbjct: 617 LVRRNDELALLYEKIKIQQSVLNKG--ESQYNQRLEDMRILRLEIKKLR 663


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 8/104 (7%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKP-DGAFLIRESSKKGCYACSVVADGEVKHCVIYSTAR 411
           ++ K W+   + R QAE +L   P DGAFL+R+ ++   YA S  A+G++KHC +     
Sbjct: 663 HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQ--E 720

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
           G       + + SL +L+ +Y++  L +      ++L YP++ +
Sbjct: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYR-----KMKLRYPINEE 759



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 46/134 (34%), Positives = 64/134 (47%), Gaps = 20/134 (14%)

Query: 334 NEDADENYFINEEDENLPHYDEKTWFVEDIN-----RVQAEDLLY------GKPDGAFLI 382
           NED +E   ++   E   H +EK WF   +      R  AE LL       G PDG+FL+
Sbjct: 529 NEDEEEPKEVSSSTEL--HSNEK-WFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLV 585

Query: 383 RESSK-KGCYACSVVADGEVKHCVIYS---TARGYGFAEPYNLYSSLKELVLHYQQTSLV 438
           RES    G Y  S   +G+V+HC I+S         F     ++ SL +L+ HYQQ  L 
Sbjct: 586 RESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL- 644

Query: 439 QHNDSLNVRLAYPV 452
              +   +RL+ PV
Sbjct: 645 -RCNEFEMRLSEPV 657



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 5/67 (7%)

Query: 83  PDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG----KYGFSDPLTFNSVVELIN 138
           PDG+FLVR++ T + GDYTL+  + G  +  +I+ R      K+  +D L F+S+ +LI 
Sbjct: 579 PDGSFLVRESETFV-GDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLIT 637

Query: 139 HYHHESL 145
           HY    L
Sbjct: 638 HYQQVPL 644


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 8/104 (7%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKP-DGAFLIRESSKKGCYACSVVADGEVKHCVIYSTAR 411
           ++ K W+   + R QAE +L   P DGAFL+R+ ++   YA S  A+G++KHC +     
Sbjct: 663 HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQ--E 720

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
           G       + + SL +L+ +Y++  L +      ++L YP++ +
Sbjct: 721 GQTVMLGNSEFDSLVDLISYYEKHPLYR-----KMKLRYPINEE 759



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 46/134 (34%), Positives = 64/134 (47%), Gaps = 20/134 (14%)

Query: 334 NEDADENYFINEEDENLPHYDEKTWFVEDIN-----RVQAEDLLY------GKPDGAFLI 382
           NED +E   ++   E   H +EK WF   +      R  AE LL       G PDG+FL+
Sbjct: 529 NEDEEEPKEVSSSTEL--HSNEK-WFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLV 585

Query: 383 RESSK-KGCYACSVVADGEVKHCVIYS---TARGYGFAEPYNLYSSLKELVLHYQQTSLV 438
           RES    G Y  S   +G+V+HC I+S         F     ++ SL +L+ HYQQ  L 
Sbjct: 586 RESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL- 644

Query: 439 QHNDSLNVRLAYPV 452
              +   +RL+ PV
Sbjct: 645 -RCNEFEMRLSEPV 657



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 5/67 (7%)

Query: 83  PDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG----KYGFSDPLTFNSVVELIN 138
           PDG+FLVR++ T + GDYTL+  + G  +  +I+ R      K+  +D L F+S+ +LI 
Sbjct: 579 PDGSFLVRESETFV-GDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLIT 637

Query: 139 HYHHESL 145
           HY    L
Sbjct: 638 HYQQVPL 644


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 9/103 (8%)

Query: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRD--MPDGTFLVRDASTKMQGDYTLT 103
           T  +P+       S+Q  EWY+G I R++   +L     P G FL+R++ T  +G Y+L+
Sbjct: 125 TGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESET-TKGAYSLS 183

Query: 104 LR-----KGGNNKLIKIYHRD-GKYGFSDPLTFNSVVELINHY 140
           +R     +G + K  KI   D G Y  +  + FNSV EL+ HY
Sbjct: 184 IRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 37/108 (34%), Positives = 47/108 (43%), Gaps = 13/108 (12%)

Query: 358 WFVEDINRVQAEDLLY--GKPDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYST 409
           W+   I R  AE  L   G P GAFLIRES + KG Y+ S+          VKH  I   
Sbjct: 144 WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKL 203

Query: 410 ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 457
             G  +      ++S++ELV HY +      ND L   L  P     P
Sbjct: 204 DMGGYYITTRVQFNSVQELVQHYMEV-----NDGLCNLLIAPCTIMKP 246


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 9/103 (8%)

Query: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRD--MPDGTFLVRDASTKMQGDYTLT 103
           T  +P+       S+Q  EWY+G I R++   +L     P G FL+R++ T  +G Y+L+
Sbjct: 125 TGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESET-TKGAYSLS 183

Query: 104 LR-----KGGNNKLIKIYHRD-GKYGFSDPLTFNSVVELINHY 140
           +R     +G + K  KI   D G Y  +  + FNSV EL+ HY
Sbjct: 184 IRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 37/108 (34%), Positives = 47/108 (43%), Gaps = 13/108 (12%)

Query: 358 WFVEDINRVQAEDLLY--GKPDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYST 409
           W+   I R  AE  L   G P GAFLIRES + KG Y+ S+          VKH  I   
Sbjct: 144 WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKL 203

Query: 410 ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 457
             G  +      ++S++ELV HY +      ND L   L  P     P
Sbjct: 204 DMGGYYITTRVQFNSVQELVQHYMEV-----NDGLCNLLIAPCTIMKP 246


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 9/103 (8%)

Query: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRD--MPDGTFLVRDASTKMQGDYTLT 103
           T  +P+       S+Q  EWY+G I R++   +L     P G FL+R++ T  +G Y+L+
Sbjct: 125 TGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESET-TKGAYSLS 183

Query: 104 LR-----KGGNNKLIKIYHRD-GKYGFSDPLTFNSVVELINHY 140
           +R     +G + K  KI   D G Y  +  + FNSV EL+ HY
Sbjct: 184 IRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 37/108 (34%), Positives = 47/108 (43%), Gaps = 13/108 (12%)

Query: 358 WFVEDINRVQAEDLLY--GKPDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYST 409
           W+   I R  AE  L   G P GAFLIRES + KG Y+ S+          VKH  I   
Sbjct: 144 WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKL 203

Query: 410 ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 457
             G  +      ++S++ELV HY +      ND L   L  P     P
Sbjct: 204 DMGGYYITTRVQFNSVQELVQHYMEV-----NDGLCNLLIAPCTIMKP 246


>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
           [Homo sapiens]
          Length = 275

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 8/88 (9%)

Query: 60  LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
           L+++ WYWG I+  E    L+ MP+GTFLVRD ST     +TL+++       ++I + D
Sbjct: 94  LRESGWYWGSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYAD 152

Query: 120 GKYGFSDP-------LTFNSVVELINHY 140
             +            L F  VV L+ HY
Sbjct: 153 SSFRLDSNCLSRPRILAFPDVVSLVQHY 180


>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
           [Homo sapiens]
          Length = 258

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 8/88 (9%)

Query: 60  LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
           L+++ WYWG I+  E    L+ MP+GTFLVRD ST     +TL+++       ++I + D
Sbjct: 77  LRESGWYWGSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYAD 135

Query: 120 GKYGFSDP-------LTFNSVVELINHY 140
             +            L F  VV L+ HY
Sbjct: 136 SSFRLDSNCLSRPRILAFPDVVSLVQHY 163


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 52/226 (23%), Positives = 103/226 (45%), Gaps = 26/226 (11%)

Query: 162 RYQQDQLVKEDNIDAVGKKLQEYHS--QYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAF 219
           R ++    KE+ I  + +K+ E     + +EK +E +++ E+  R  QE +M R      
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ----- 435

Query: 220 NETIKIFEEQCHTQEQ---HSKEYI---ERFRREGNEKEIERIMMNYDKL---------K 264
            E I+  EE+   QE+     +E I   E+ R E   +E E +    +K+         K
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495

Query: 265 SRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDL-IQLRKIRDQHLVWLNHKGVRQ 323
            ++ E  +   + E+ +  Q    RE ++K+   +  +  Q  KIR+Q  +W   + + +
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555

Query: 324 KRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAE 369
           +   +W   K ++ ++  +   ++E +   +EK W  E+  R Q E
Sbjct: 556 QE-KIWEEEKRQEQEDKMW--RQEEKIREQEEKVWRQEEKIREQEE 598



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 47/208 (22%), Positives = 103/208 (49%), Gaps = 31/208 (14%)

Query: 162 RYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSK--EYDRLYEEYTRTSQEIQMKRTAIEAF 219
           R Q++++ +++      +K++E    ++E+ K  E ++++EE  R  QE +M R      
Sbjct: 527 REQEEKMWRQE------EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ----- 575

Query: 220 NETIKIFEEQCHTQEQHSKEYIERFRREGNE---KEIERIMMNYDKLKSRLGEIHDSKMR 276
            E I+  EE+   QE+  +E  E+ R+E  E   K+ E+I    +K++ +  +I +    
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ--- 631

Query: 277 LEQDLKNQALDNREIDKKMNSIKPDLI-QLRKIRDQ-HLVWLNHKGVRQKRLNVWLGIKN 334
            E+ ++ Q    +E ++KM   +  +  Q  K+++Q   +W   + +R++   +      
Sbjct: 632 -EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI------ 684

Query: 335 EDADENYFINEEDENLPHYDEKTWFVED 362
              ++   I E++E +   +EK W  E+
Sbjct: 685 --REQEEKIREQEEMMQEQEEKMWEQEE 710



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 53/245 (21%), Positives = 103/245 (42%), Gaps = 28/245 (11%)

Query: 143 ESLAQYNPKLDVKLMYPVSRYQQDQL-VKE------------------DNIDAVGKKLQE 183
           E L + N KL  KL    S   + QL VKE                     D +GK+LQ 
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276

Query: 184 YHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIER 243
             ++ Q + +E +       +  +++  +   I+ + E I+  EE+   QE+  +E  E+
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336

Query: 244 FRR------EGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNS 297
            RR      E  EK   +  M ++K + ++    +     E+ ++ Q     E ++K+  
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEK-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 395

Query: 298 IKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKT 357
           ++  + +  KIR+Q       + +R++        K    +E   I E++E +   ++K 
Sbjct: 396 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK--IREQEEKIREQEKKM 453

Query: 358 WFVED 362
           W  E+
Sbjct: 454 WRQEE 458



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 49/244 (20%), Positives = 105/244 (43%), Gaps = 35/244 (14%)

Query: 155 KLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRT 214
           K+     R +Q+++ +++      +K+ E    +++K K +++  E+  +  +++  +  
Sbjct: 465 KIREEEKRQEQEEMWRQE------EKIHEQEEIWRQKEKMHEQ-EEKIRKQEEKVWRQEE 517

Query: 215 AIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERI------MMNYDKL---KS 265
            I    E I+  EE+   QE+  +E  E +R E    E E+I          DK+   + 
Sbjct: 518 KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577

Query: 266 RLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQ-HLVWLNHKGVRQK 324
           ++ E  +   R E+ ++ Q    +E ++KM        Q  KIR+Q   +    + +R++
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWK------QEEKIREQEEKIQEQEEKIREQ 631

Query: 325 RLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRE 384
              +         ++     E++E +   +EK    E+  + Q E +   +      IRE
Sbjct: 632 EEKI--------REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK----IRE 679

Query: 385 SSKK 388
             KK
Sbjct: 680 QEKK 683


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 36/117 (30%), Positives = 51/117 (43%), Gaps = 8/117 (6%)

Query: 43  KPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTL 102
           KP     P   +D SV L    WY G + R      L +  DGTFLVR    K   ++ +
Sbjct: 656 KPYVHGPP---QDLSVHL----WYAGPMERAGAESILANRSDGTFLVRQR-VKDAAEFAI 707

Query: 103 TLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYP 159
           +++     K IKI   +G Y  ++   F  + EL+  Y   SL      LD  L +P
Sbjct: 708 SIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 764



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 2/95 (2%)

Query: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKKGC-YACSVVADGEVKHCVIYSTARGYGFA 416
           W+   + R  AE +L  + DG FL+R+  K    +A S+  + EVKH  I  TA G    
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI-MTAEGLYRI 729

Query: 417 EPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP 451
                +  L ELV  YQQ SL     SL+  L +P
Sbjct: 730 TEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 764


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 45/117 (38%), Positives = 61/117 (52%), Gaps = 12/117 (10%)

Query: 346 EDENLPHYDEKTWFVEDINRVQAE-DLLYGK-PDGAFLIRES-SKKGCYACSVVADGEVK 402
           ED +L     + WF   I R  AE  LLY +   G+FLIRES S+KG ++ SV+    VK
Sbjct: 107 EDRSL---QAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVK 163

Query: 403 HCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP-VHAQMPS 458
           H  I     G  F     ++S+L E V HY +TS     D L V+L  P +  Q+P+
Sbjct: 164 HYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTS-----DGLCVKLGKPCLKIQVPA 215



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 4/95 (4%)

Query: 49  VPNGMKDSSVSLQDAEWYWGDISREEVNDKL--RDMPDGTFLVRDASTKMQGDYTLTLRK 106
           +P+       SLQ   W++G I R +   +L   +   G+FL+R+ S   +G+++L++  
Sbjct: 100 IPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRE-SESQKGEFSLSVLD 158

Query: 107 GGNNKLIKIYHRD-GKYGFSDPLTFNSVVELINHY 140
           G   K  +I   D G +  +    F+++ E ++HY
Sbjct: 159 GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHY 193


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 24/95 (25%), Positives = 53/95 (55%), Gaps = 1/95 (1%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           W+ G++ R++ ++ L+    GT+L+R+   + +  + ++++     K IK+  +D     
Sbjct: 673 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAER-FAISIKFNDEVKHIKVVEKDNWIHI 731

Query: 125 SDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYP 159
           ++   F+S++EL+ +Y   SL +   +LD  L YP
Sbjct: 732 TEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYP 766



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKPDGAFLIRE-SSKKGCYACSVVADGEVKHCVIYSTAR 411
           Y    WF  ++ R Q ++LL     G +LIRE  ++   +A S+  + EVKH  +     
Sbjct: 668 YTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 727

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461
                E    + SL ELV +YQ  SL +    L+  L YP  ++  S  R
Sbjct: 728 WIHITEA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASR 776


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 24/95 (25%), Positives = 53/95 (55%), Gaps = 1/95 (1%)

Query: 65  WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
           W+ G++ R++ ++ L+    GT+L+R+   + +  + ++++     K IK+  +D     
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAER-FAISIKFNDEVKHIKVVEKDNWIHI 721

Query: 125 SDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYP 159
           ++   F+S++EL+ +Y   SL +   +LD  L YP
Sbjct: 722 TEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYP 756



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)

Query: 353 YDEKTWFVEDINRVQAEDLLYGKPDGAFLIRE-SSKKGCYACSVVADGEVKHCVIYSTAR 411
           Y    WF  ++ R Q ++LL     G +LIRE  ++   +A S+  + EVKH  +     
Sbjct: 658 YTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 717

Query: 412 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 461
                E    + SL ELV +YQ  SL +    L+  L YP  ++  S  R
Sbjct: 718 WIHITEA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASR 766


>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
          Length = 423

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 41/137 (29%), Positives = 73/137 (53%), Gaps = 12/137 (8%)

Query: 34  PPALP---PKPPKPMT---SAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTF 87
           PP L    PK  KP++   S+      D ++ L++  WY G ISR +  + LR   + ++
Sbjct: 286 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASY 345

Query: 88  LVRDASTKMQGDYTLTLRKGGNNKLIKIYH-RDGKY--GFSDPLTFNSVVELINHYHHES 144
           LVR++ T  + D++L+L+       +K+   ++ KY  G + P  F+SV E+++HY    
Sbjct: 346 LVRNSETS-KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRK 403

Query: 145 LAQYNPKLDVKLMYPVS 161
           L     +  + L+YPV+
Sbjct: 404 LPIKGAE-HMSLLYPVA 419



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 4/108 (3%)

Query: 347 DENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCV 405
           D  LP  + + W+   I+R  AE+LL    + ++L+R S + K  ++ S+ +     H  
Sbjct: 313 DPALP-LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371

Query: 406 IYST-ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 452
           +  T    Y   +    +SS+ E+V HY    L     + ++ L YPV
Sbjct: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 44/127 (34%), Positives = 69/127 (54%), Gaps = 11/127 (8%)

Query: 330 LGIKNEDADENYF---INEEDENLP-HYDEKT---WFVEDINRVQAEDLLYG-KPDGAFL 381
           L + NE+ D+N++   +N +D  +P +Y E     WF   I R +AE++L   + DGAFL
Sbjct: 25  LKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFL 84

Query: 382 IRES-SKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQH 440
           IRES S  G ++ SV    +V+H  +     G  F      ++SL ELV +++ TS V  
Sbjct: 85  IRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVK-FNSLNELVDYHRSTS-VSR 142

Query: 441 NDSLNVR 447
           N  + +R
Sbjct: 143 NQQIFLR 149



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/93 (30%), Positives = 55/93 (59%), Gaps = 6/93 (6%)

Query: 58  VSLQDAEWYWGDISREEVNDKL-RDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIY 116
           + ++   W++G I R +  + L +   DG FL+R+ S    GD++L+++ G + +  K+ 
Sbjct: 53  IEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRE-SESAPGDFSLSVKFGNDVQHFKVL 111

Query: 117 HRDG--KYGFSDPLTFNSVVELINHYHHESLAQ 147
            RDG  KY F   + FNS+ EL++++   S+++
Sbjct: 112 -RDGAGKY-FLWVVKFNSLNELVDYHRSTSVSR 142


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 41/139 (29%), Positives = 69/139 (49%), Gaps = 16/139 (11%)

Query: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDM--PDGTFLVRDASTKMQGDYTLT 103
           T  +P+       S+Q  EWY+G + R++   +L     P GTFL+R++ T  +G Y+L+
Sbjct: 130 TGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET-TKGAYSLS 188

Query: 104 LR-----KGGNNKLIKIYHRD-GKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVK-- 155
           +R     KG + K  KI   D G Y  +    F ++ +L+ HY        N K+ +K  
Sbjct: 189 IRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY--SGTWNGNTKVAIKTL 246

Query: 156 ---LMYPVSRYQQDQLVKE 171
               M P S  ++ Q++K+
Sbjct: 247 KPGTMSPESFLEEAQIMKK 265



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 36/131 (27%), Positives = 54/131 (41%), Gaps = 13/131 (9%)

Query: 318 HKGVRQKRLNV-----WLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLL 372
           HKG + + LN      W        +  Y  +     +     + W+   + R  AE  L
Sbjct: 104 HKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQL 163

Query: 373 --YGKPDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYSTARGYGFAEPYNLYSS 424
             +G P G FLIRES + KG Y+ S+     +    VKH  I     G  +      + +
Sbjct: 164 LSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFET 223

Query: 425 LKELVLHYQQT 435
           L++LV HY  T
Sbjct: 224 LQQLVQHYSGT 234


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,074,536
Number of Sequences: 37866
Number of extensions: 857141
Number of successful extensions: 6824
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 409
Number of HSP's that attempted gapping in prelim test: 5640
Number of HSP's gapped (non-prelim): 1334
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.