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Search of human proteins with 166362719
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
(264 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 533 e-152
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 515 e-146
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 385 e-107
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 328 4e-90
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 326 1e-89
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 284 6e-77
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 251 5e-67
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 251 5e-67
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 249 2e-66
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 247 7e-66
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 247 7e-66
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 247 7e-66
gi|16306492 cell division cycle 2 isoform 2 [Homo sapiens] 232 3e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 220 9e-58
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 206 1e-53
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 206 1e-53
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 203 1e-52
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 199 2e-51
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 195 3e-50
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 195 3e-50
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 195 4e-50
gi|30795215 cell cycle related kinase isoform 2 [Homo sapiens] 194 5e-50
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 193 1e-49
gi|30795255 cell cycle related kinase isoform 1 [Homo sapiens] 186 2e-47
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 186 2e-47
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 533 bits (1372), Expect = e-152
Identities = 264/264 (100%), Positives = 264/264 (100%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR 180
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR 180
Query: 181 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 240
IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR
Sbjct: 181 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 240
Query: 241 ISAKAALAHPFFQDVTKPVPHLRL 264
ISAKAALAHPFFQDVTKPVPHLRL
Sbjct: 241 ISAKAALAHPFFQDVTKPVPHLRL 264
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 515 bits (1327), Expect = e-146
Identities = 264/298 (88%), Positives = 264/298 (88%), Gaps = 34/298 (11%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE------------------ 162
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 163 ----------------VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 206
VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
Query: 207 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 264
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Sbjct: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 385 bits (989), Expect = e-107
Identities = 197/297 (66%), Positives = 226/297 (76%), Gaps = 35/297 (11%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M+ FQKVEKIGEGTYGVVYKA+N+ TG++VALKKIRLD E EGVPSTAIREISLLKEL H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
PNIV+LLDV+H E KLYLVFEFL QDLKK+MD++ + +PL LIKSYLFQLLQG++FCHS
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE------------------ 162
HRV+HRDLKPQNLLIN GAIKLADFGLARAFGVP+RTYTHE
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 163 ----------------VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 206
VTR+ALFPGDSEIDQLFRIFR LGTP E WPGVT +PDYK SF
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF 240
Query: 207 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 263
PKW R+ ++VP L+ +GR LL Q+L YDP++RI+AK ALAHP+F +P P R
Sbjct: 241 PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS-PEPSPAAR 296
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 328 bits (840), Expect = 4e-90
Identities = 172/295 (58%), Positives = 207/295 (70%), Gaps = 37/295 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118
PNIV L DV+ +++LYL+FEFL DLKK++D S G + L+KSYL+Q+LQG+ FC
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFC 119
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
HS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEV
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239
Query: 205 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ +
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 326 bits (836), Expect = 1e-89
Identities = 171/295 (57%), Positives = 206/295 (69%), Gaps = 37/295 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118
PNIV L DV+ +++LYL+FEFL DLKK++D S G + L+KSYL+Q+LQG+ FC
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFC 119
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---------------- 162
HS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHE
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSA 179
Query: 163 ------------------VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239
Query: 205 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ +
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 284 bits (726), Expect = 6e-77
Identities = 154/294 (52%), Positives = 191/294 (64%), Gaps = 38/294 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M+ ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV+L DV+H++ KL LVFEF QDLKK+ D S + ++KS+LFQLL+GL FCHS
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHS 119
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTR--------------- 165
VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EV
Sbjct: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
Query: 166 --------------------RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 205
R LFPG+ DQL RIFR LGTP E WP +T +PDYKP
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP- 238
Query: 206 FPKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 258
+P + A VVP L+ GR LL +L +P +RISA+ AL HP+F D P
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 251 bits (641), Expect = 5e-67
Identities = 137/287 (47%), Positives = 182/287 (63%), Gaps = 37/287 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH
Sbjct: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 285
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
+VLHRDLKPQNLLIN G +KLADFGLARA +P +TY++EV
Sbjct: 286 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 345
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
T R LFPG + +QL IFR LGTP E WPG+ S ++K +
Sbjct: 346 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 252
+PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF
Sbjct: 406 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 251 bits (641), Expect = 5e-67
Identities = 137/287 (47%), Positives = 182/287 (63%), Gaps = 37/287 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 279
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
+VLHRDLKPQNLLIN G +KLADFGLARA +P +TY++EV
Sbjct: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
T R LFPG + +QL IFR LGTP E WPG+ S ++K +
Sbjct: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 252
+PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF
Sbjct: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 249 bits (636), Expect = 2e-66
Identities = 134/290 (46%), Positives = 185/290 (63%), Gaps = 37/290 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME + K+EK+GEGTY VYK R+KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D++HT+ L LVFE+L +DLK++MD + + +K +L+Q+L+GLA+CH
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
+VLHRDLKPQNLLIN +G +KLADFGLARA VP +TY++EV
Sbjct: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
+ R LFPG + D+L IFR LGTP + WPG++S ++K +
Sbjct: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255
FPK+ Q P LD +G L+++ L Y+ KR+SA+ A+ H +F+ +
Sbjct: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 247 bits (631), Expect = 7e-66
Identities = 138/297 (46%), Positives = 185/297 (62%), Gaps = 37/297 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 288
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EV
Sbjct: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 262
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 247 bits (631), Expect = 7e-66
Identities = 138/297 (46%), Positives = 185/297 (62%), Gaps = 37/297 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EV
Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 262
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 247 bits (631), Expect = 7e-66
Identities = 138/297 (46%), Positives = 185/297 (62%), Gaps = 37/297 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EV
Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318
Query: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
Query: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 262
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
>gi|16306492 cell division cycle 2 isoform 2 [Homo sapiens]
Length = 240
Score = 232 bits (591), Expect = 3e-61
Identities = 130/259 (50%), Positives = 169/259 (65%), Gaps = 22/259 (8%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
PNIV L DV+ +++LYL+FEFL DLKK++D+ P + S L +++
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKVV-------- 108
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR 180
+ +R P+ LL + + + + + F T++ LF GDSEIDQLFR
Sbjct: 109 -TLWYR--SPEVLLGSARYSTPVDIWSIGTIF-------AELATKKPLFHGDSEIDQLFR 158
Query: 181 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 240
IFR LGTP+ VWP V S+ DYK +FPKW + V LDE+G LLS+ML YDP KR
Sbjct: 159 IFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 218
Query: 241 ISAKAALAHPFFQDVTKPV 259
IS K AL HP+F D+ +
Sbjct: 219 ISGKMALNHPYFNDLDNQI 237
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 220 bits (561), Expect = 9e-58
Identities = 130/292 (44%), Positives = 175/292 (59%), Gaps = 40/292 (13%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
++++K+EK+GEG+Y VYK ++K+ G++VALK IRL E EG P TAIRE SLLK L H
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV L D+IHT+ L LVFE++H DL ++MD G+ +K +LFQLL+GL++ H
Sbjct: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRR--------------- 166
+LHRDLKPQNLLI+ G +KLADFGLARA VP TY++EV
Sbjct: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
Query: 167 -------------------ALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 205
A FPG +I DQL RIF LGTP+E WPGV S+P +KP
Sbjct: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
Query: 206 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255
F ++ ++ + L L S++L P R+SA+AAL+H +F D+
Sbjct: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 206 bits (525), Expect = 1e-53
Identities = 121/297 (40%), Positives = 171/297 (57%), Gaps = 43/297 (14%)
Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
+ ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVT-------- 164
+GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + + VT
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 165 ------------------------RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 200
R+ LF G S++DQL +I +G P E WP ++P
Sbjct: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250
Query: 201 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 257
+ +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ +
Sbjct: 251 --RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 206 bits (525), Expect = 1e-53
Identities = 121/297 (40%), Positives = 171/297 (57%), Gaps = 43/297 (14%)
Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
+ ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVT-------- 164
+GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + + VT
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 165 ------------------------RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 200
R+ LF G S++DQL +I +G P E WP ++P
Sbjct: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250
Query: 201 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 257
+ +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ +
Sbjct: 251 --RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 203 bits (516), Expect = 1e-52
Identities = 115/300 (38%), Positives = 168/300 (56%), Gaps = 39/300 (13%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKEL 58
+ ++K++ +GEG + VYKAR+K T ++VA+KKI+L +E G+ TA+REI LL+EL
Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
+HPNI+ LLD ++ + LVF+F+ DL+ + ++L P IK+Y+ LQGL +
Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYMLMTLQGLEYL 128
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRR------------ 166
H H +LHRDLKP NLL++ G +KLADFGLA++FG P R YTH+V R
Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 167 ----------------------ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
PGDS++DQL RIF TLGTP E WP + S+PDY
Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY-V 247
Query: 205 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 264
+F + + +D L+ + ++P RI+A AL +F + P P +L
Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL 307
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 199 bits (507), Expect = 2e-51
Identities = 122/288 (42%), Positives = 164/288 (56%), Gaps = 40/288 (13%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
++ +EK+GEG+Y VYK +++ G++VALK I ++ E EGVP TAIRE SLLK L H N
Sbjct: 51 SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHAN 109
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
IV L D+IHT+ L VFE++H DL ++M G+ ++ ++FQLL+GLA+ H
Sbjct: 110 IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHP-GGLHPHNVRLFMFQLLRGLAYIHHQH 168
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTR----------------- 165
VLHRDLKPQNLLI+ G +KLADFGLARA +P +TY+ EV
Sbjct: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228
Query: 166 -----------------RALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-F 206
+ LFPG S I +QL +I+ LG P E WPGV+ +P+Y P F
Sbjct: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
Query: 207 PKWARQDFSKVVPPLDE--DGRSLLSQMLHYDPNKRISAKAALAHPFF 252
P + V L + L SQML P R+SA+ AL H +F
Sbjct: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 195 bits (496), Expect = 3e-50
Identities = 107/297 (36%), Positives = 171/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 528
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG+SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 705
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 195 bits (496), Expect = 3e-50
Identities = 107/297 (36%), Positives = 171/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 538
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 598
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG+SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 658
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 529
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 706
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 538
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 598
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 658
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 506
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 507 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 566
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 567 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 626
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 627 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 683
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 495
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 284
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 285 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 344
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 461
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 195 bits (495), Expect = 4e-50
Identities = 107/297 (36%), Positives = 170/297 (57%), Gaps = 39/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLP-GEVKTLMIQLLRGVKHL 540
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------- 163
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT V
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
Query: 164 -------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 204
T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
Query: 205 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 259
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 717
>gi|30795215 cell cycle related kinase isoform 2 [Homo sapiens]
Length = 325
Score = 194 bits (494), Expect = 5e-50
Identities = 113/276 (40%), Positives = 165/276 (59%), Gaps = 19/276 (6%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-N 59
M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G P+ A+REI L+E+ +
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
+ +V+L V L FEF+ DL + + A + +KSYL LL+G+AFCH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLLKGVAFCH 119
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVTRRA----------- 167
++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V R+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNG 179
Query: 168 --LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDED 224
LFPG ++I+QL + R LGTP+ VWP +T +PDY K SF + +V+P +
Sbjct: 180 SPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQ 239
Query: 225 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 260
LL Q L Y P++RI+A AL H +F T P+P
Sbjct: 240 ALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 273
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 193 bits (490), Expect = 1e-49
Identities = 117/302 (38%), Positives = 169/302 (55%), Gaps = 50/302 (16%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ F+K+ +IGEGTYG+VY+AR+ T E+VALKK+R+D E +G+P +++REI+LL L H
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 61 PNIVKLLDVI---HTENKLYLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQ 113
PNIV+L +V+ H E+ ++LV + QDL AS L +P P +K + Q+L+
Sbjct: 96 PNIVELKEVVVGNHLES-IFLVMGYCEQDL-----ASLLENMPTPFSEAQVKCIVLQVLR 149
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV---------- 163
GL + H + ++HRDLK NLL+ +G +K ADFGLARA+GVPV+ T +V
Sbjct: 150 GLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPEL 209
Query: 164 ------------------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 199
R L PG SEI Q+ I + LGTP E +WPG + +
Sbjct: 210 LLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKL 269
Query: 200 PDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 258
P + S K + P L E G LL + YDP KR +A L +F++ KP
Sbjct: 270 PLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE--KP 327
Query: 259 VP 260
+P
Sbjct: 328 LP 329
>gi|30795255 cell cycle related kinase isoform 1 [Homo sapiens]
Length = 338
Score = 186 bits (471), Expect = 2e-47
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 32/289 (11%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNK-------------LTGEVVALKKIRLDTETEGVPST 47
M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G P+
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVEPRVGWQCLPSILQTGEIVALKKVALRRLEDGFPNQ 60
Query: 48 AIREISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS 106
A+REI L+E+ ++ +V+L V L FEF+ DL + + A + +KS
Sbjct: 61 ALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKS 119
Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVTR 165
YL LL+G+AFCH++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V
Sbjct: 120 YLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVAT 179
Query: 166 RA-------------LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWAR 211
R+ LFPG ++I+QL + R LGTP+ VWP +T +PDY K SF +
Sbjct: 180 RSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVP 239
Query: 212 QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 260
+V+P + LL Q L Y P++RI+A AL H +F T P+P
Sbjct: 240 MPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 286
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 186 bits (471), Expect = 2e-47
Identities = 113/297 (38%), Positives = 164/297 (55%), Gaps = 40/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-N 59
M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G P+ A+REI L+E+ +
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
+ +V+L V L FEF+ DL + + A + +KSYL LL+G+AFCH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLLKGVAFCH 119
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVTRR------------ 166
++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V R
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179
Query: 167 ----------------------ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-K 203
LFPG ++I+QL + R LGTP+ VWP +T +PDY K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239
Query: 204 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 260
SF + +V+P + LL Q L Y P++RI+A AL H +F T P+P
Sbjct: 240 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,844,355
Number of Sequences: 37866
Number of extensions: 431676
Number of successful extensions: 3101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 925
Number of HSP's gapped (non-prelim): 1135
length of query: 264
length of database: 18,247,518
effective HSP length: 100
effective length of query: 164
effective length of database: 14,460,918
effective search space: 2371590552
effective search space used: 2371590552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.