Search of human proteins with 163659856

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
         (894 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p...  1801   0.0  
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p...  1783   0.0  
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p...  1370   0.0  
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p...  1336   0.0  
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre...  1307   0.0  
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr...  1290   0.0  
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H...  1283   0.0  
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H...  1200   0.0  
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H...  1191   0.0  
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ...   611   e-175
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ...   611   e-175
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ...   600   e-171
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p...   592   e-169
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ...   584   e-166
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p...   546   e-155
gi|164419739 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p...   546   e-155
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]           528   e-149
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]           513   e-145
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]   340   5e-93
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H...   327   3e-89
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]    225   1e-58
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]    222   1e-57
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]    222   1e-57
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ...   179   1e-44
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ...   177   5e-44
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ...   177   5e-44
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr...   177   5e-44
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [...   172   1e-42
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ...   167   3e-41
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate...   157   3e-38

>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
           precursor [Homo sapiens]
          Length = 894

 Score = 1801 bits (4665), Expect = 0.0
 Identities = 894/894 (100%), Positives = 894/894 (100%)

Query: 1   MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT 60
           MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT
Sbjct: 1   MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT 60

Query: 61  NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL 120
           NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL
Sbjct: 61  NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL 120

Query: 121 HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180
           HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA
Sbjct: 121 HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180

Query: 181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS 240
           AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS
Sbjct: 181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS 240

Query: 241 RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN 300
           RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN
Sbjct: 241 RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN 300

Query: 301 APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM 360
           APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM
Sbjct: 301 APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM 360

Query: 361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS 420
           VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS
Sbjct: 361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS 420

Query: 421 ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY 480
           ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY
Sbjct: 421 ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY 480

Query: 481 GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 540
           GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS
Sbjct: 481 GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 540

Query: 541 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 600
           KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP
Sbjct: 541 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 600

Query: 601 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 660
           NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER
Sbjct: 601 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 660

Query: 661 MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD 720
           MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD
Sbjct: 661 MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD 720

Query: 721 GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNL 780
           GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNL
Sbjct: 721 GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNL 780

Query: 781 AVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMM 840
           AVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMM
Sbjct: 781 AVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMM 840

Query: 841 VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Sbjct: 841 VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894


>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
           precursor [Homo sapiens]
          Length = 894

 Score = 1783 bits (4619), Expect = 0.0
 Identities = 885/894 (98%), Positives = 888/894 (99%)

Query: 1   MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT 60
           MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT
Sbjct: 1   MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT 60

Query: 61  NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL 120
           NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL
Sbjct: 61  NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL 120

Query: 121 HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180
           HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA
Sbjct: 121 HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180

Query: 181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS 240
           AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS
Sbjct: 181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS 240

Query: 241 RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN 300
           RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN
Sbjct: 241 RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN 300

Query: 301 APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM 360
           APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM
Sbjct: 301 APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM 360

Query: 361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS 420
           VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS
Sbjct: 361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS 420

Query: 421 ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY 480
           ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY
Sbjct: 421 ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY 480

Query: 481 GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 540
           GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS
Sbjct: 481 GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 540

Query: 541 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 600
           KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP
Sbjct: 541 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 600

Query: 601 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 660
           NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER
Sbjct: 601 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 660

Query: 661 MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD 720
           MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD
Sbjct: 661 MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD 720

Query: 721 GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNL 780
           GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALG  VNL
Sbjct: 721 GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNL 780

Query: 781 AVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMM 840
           AVLKL+EQG+LDKLKNKWWYDKGECG+    SKDKTSALSLSNVAGVFYILVGGLGLAMM
Sbjct: 781 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM 840

Query: 841 VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Sbjct: 841 VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894


>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
           precursor [Homo sapiens]
          Length = 884

 Score = 1370 bits (3547), Expect = 0.0
 Identities = 662/887 (74%), Positives = 774/887 (87%), Gaps = 9/887 (1%)

Query: 11  VLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFH 70
           + R +  L  G  G + G FP+++ IGGLF+RNT QE++AFR A+ L+NT+ N +E PF+
Sbjct: 4   ISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFN 63

Query: 71  LNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130
           L  HVD+++++NSF+VTNAFCSQ+SRGV+AIFG YD+ S++TLTSFC ALH S +TPSFP
Sbjct: 64  LVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP 123

Query: 131 TDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
           T+ + QFV+Q+RP+L+GA+LSLL HY+W  FV+LYDT+RG+SILQAIME A QN W V+A
Sbjct: 124 TEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSA 183

Query: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
             V N  DV  +R+++EE+DRRQEK+++IDCE+ER+  ILEQ+V +GKH +GYHY++ANL
Sbjct: 184 ICVENFNDVS-YRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALT 310
           GF DI LER +HGGAN+TGFQ+V+   PMV + + RW +LD+RE+P ++  P KYTSALT
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPP-KYTSALT 301

Query: 311 HDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNI 370
           +D +LV+AE FR LRRQ++D+SRRG+AGDCLANPA PW QGID+ER LK V++QG+TGN+
Sbjct: 302 YDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNV 361

Query: 371 QFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSD-QQISNDSASSENRTIVVTT 429
           QFD YGRR NYT+DV+E+K +G RK GYWN+ ++ V   D   + ND+A+ ENRT+VVTT
Sbjct: 362 QFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTT 421

Query: 430 ILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKI 489
           I+ESPYVMYKKNHE  EGN++YEGYCVDLA EIAKH+ IKYK++IV DGKYGARD +TKI
Sbjct: 422 IMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKI 481

Query: 490 WNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 549
           WNGMVGELVYG+A+IA+APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
Sbjct: 482 WNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 541

Query: 550 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD--PPNEFGIFN 607
           PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH     EEP D +  P   PPNEFGIFN
Sbjct: 542 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH----TEEPEDGKEGPSDQPPNEFGIFN 597

Query: 608 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 667
           SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES
Sbjct: 598 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 657

Query: 668 AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRK 727
           AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW+YM+SAEPSVFT+TTA+GVARVRK
Sbjct: 658 AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRK 717

Query: 728 SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSE 787
           SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS+LG  VNLAVLKL+E
Sbjct: 718 SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNE 777

Query: 788 QGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFC 847
           QG+LDKLKNKWWYDKGECG+    SKDKTSALSLSNVAGVFYILVGGLGLAM+VALIEFC
Sbjct: 778 QGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 837

Query: 848 YKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           YKSRAE+KRMK+ K+ Q F P  + NTQN ATYREGYNVYGTES+KI
Sbjct: 838 YKSRAEAKRMKVAKSAQTFNPTSSQNTQNLATYREGYNVYGTESIKI 884


>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
           precursor [Homo sapiens]
          Length = 902

 Score = 1336 bits (3457), Expect = 0.0
 Identities = 646/853 (75%), Positives = 752/853 (88%), Gaps = 9/853 (1%)

Query: 11  VLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFH 70
           + R +  L  G  G + G FP+++ IGGLF+RNT QE++AFR A+ L+NT+ N +E PF+
Sbjct: 4   ISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFN 63

Query: 71  LNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130
           L  HVD+++++NSF+VTNAFCSQ+SRGV+AIFG YD+ S++TLTSFC ALH S +TPSFP
Sbjct: 64  LVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP 123

Query: 131 TDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
           T+ + QFV+Q+RP+L+GA+LSLL HY+W  FV+LYDT+RG+SILQAIME A QN W V+A
Sbjct: 124 TEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSA 183

Query: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
             V N  DV  +R+++EE+DRRQEK+++IDCE+ER+  ILEQ+V +GKH +GYHY++ANL
Sbjct: 184 ICVENFNDVS-YRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALT 310
           GF DI LER +HGGAN+TGFQ+V+   PMV + + RW +LD+RE+P ++  P KYTSALT
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPP-KYTSALT 301

Query: 311 HDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNI 370
           +D +LV+AE FR LRRQ++D+SRRG+AGDCLANPA PW QGID+ER LK V++QG+TGN+
Sbjct: 302 YDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNV 361

Query: 371 QFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSD-QQISNDSASSENRTIVVTT 429
           QFD YGRR NYT+DV+E+K +G RK GYWN+ ++ V   D   + ND+A+ ENRT+VVTT
Sbjct: 362 QFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTT 421

Query: 430 ILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKI 489
           I+ESPYVMYKKNHE  EGN++YEGYCVDLA EIAKH+ IKYK++IV DGKYGARD +TKI
Sbjct: 422 IMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKI 481

Query: 490 WNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 549
           WNGMVGELVYG+A+IA+APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
Sbjct: 482 WNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 541

Query: 550 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD--PPNEFGIFN 607
           PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH     EEP D +  P   PPNEFGIFN
Sbjct: 542 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH----TEEPEDGKEGPSDQPPNEFGIFN 597

Query: 608 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 667
           SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES
Sbjct: 598 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 657

Query: 668 AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRK 727
           AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW+YM+SAEPSVFT+TTA+GVARVRK
Sbjct: 658 AEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRK 717

Query: 728 SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSE 787
           SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS+LGTPVNLAVLKLSE
Sbjct: 718 SKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSE 777

Query: 788 QGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFC 847
            G+LDKLKNKWWYDKGECG KDSGSKDKTSALSLSNVAGVFYILVGGLGLAM+VALIEFC
Sbjct: 778 AGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 837

Query: 848 YKSRAESKRMKLT 860
           YKSRAE+KRMKLT
Sbjct: 838 YKSRAEAKRMKLT 850


>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
           precursor [Homo sapiens]
          Length = 883

 Score = 1307 bits (3383), Expect = 0.0
 Identities = 637/890 (71%), Positives = 762/890 (85%), Gaps = 12/890 (1%)

Query: 9   QSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKP 68
           Q ++     L   L G   G   N+I IGGLF R   QE+SAFR  +  ++T++      
Sbjct: 2   QKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSE------ 55

Query: 69  FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPS 128
           F L  H+D+L+ +NSF+VTNAFCSQFSRGVYAIFGFYD+ S+NT+TSFCG LH SF+TPS
Sbjct: 56  FRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPS 115

Query: 129 FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQV 188
           FPTD    FVIQMRP LKGA+LSL+ +Y+W+KF YLYD++RG S LQA++++A +  WQV
Sbjct: 116 FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQV 175

Query: 189 TARSVGNI---KDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY 245
           TA +VGNI   K  + +R + ++++ ++E+R ++DCE +++N I++QV+ +GKH +GYHY
Sbjct: 176 TAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHY 235

Query: 246 MLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKY 305
           ++ANLGFTD  L ++  GGAN++GFQIV+ ++ +V +FI+RW  L+E+E+P A    +KY
Sbjct: 236 IIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKY 295

Query: 306 TSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQG 365
           TSALT+DA+ V+ EAFR LR+QR+++SRRG+AGDCLANPAVPW QG++IERALK VQV+G
Sbjct: 296 TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 355

Query: 366 MTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV-PFSDQQISNDSASSENRT 424
           ++GNI+FD  G+R NYTI++ E+K +G RK GYW+E ++ V   ++    ND++  EN+T
Sbjct: 356 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 415

Query: 425 IVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARD 484
           +VVTTILESPYVM KKNHE LEGNERYEGYCVDLA EIAKH   KYKL+IVGDGKYGARD
Sbjct: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475

Query: 485 PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 544
            +TKIWNGMVGELVYG+ADIA+APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535

Query: 545 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFG 604
           FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH E+  E+ R+ QS  +  NEFG
Sbjct: 536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEF-EDGRETQSS-ESTNEFG 593

Query: 605 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 664
           IFNSLWFSLGAFM+QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP
Sbjct: 594 IFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653

Query: 665 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVAR 724
           IESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GVAR
Sbjct: 654 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVAR 713

Query: 725 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLK 784
           VRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGS+L TPVNLAVLK
Sbjct: 714 VRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLK 773

Query: 785 LSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALI 844
           LSEQG+LDKLKNKWWYDKGECGAKDSGSK+KTSALSLSNVAGVFYILVGGLGLAM+VALI
Sbjct: 774 LSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALI 833

Query: 845 EFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           EFCYKSRAE+KRMK+ KN QN  P+ + N+QN+ATY+EGYNVYG ESVKI
Sbjct: 834 EFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI 883


>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
           precursor [Homo sapiens]
          Length = 883

 Score = 1290 bits (3338), Expect = 0.0
 Identities = 629/890 (70%), Positives = 756/890 (84%), Gaps = 12/890 (1%)

Query: 9   QSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKP 68
           Q ++     L   L G   G   N+I IGGLF R   QE+SAFR  +  ++T++      
Sbjct: 2   QKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSE------ 55

Query: 69  FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPS 128
           F L  H+D+L+ +NSF+VTNAFCSQFSRGVYAIFGFYD+ S+NT+TSFCG LH SF+TPS
Sbjct: 56  FRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPS 115

Query: 129 FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQV 188
           FPTD    FVIQMRP LKGA+LSL+ +Y+W+KF YLYD++RG S LQA++++A +  WQV
Sbjct: 116 FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQV 175

Query: 189 TARSVGNI---KDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY 245
           TA +VGNI   K  + +R + ++++ ++E+R ++DCE +++N I++QV+ +GKH +GYHY
Sbjct: 176 TAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHY 235

Query: 246 MLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKY 305
           ++ANLGFTD  L ++  GGAN++GFQIV+ ++ +V +FI+RW  L+E+E+P A    +KY
Sbjct: 236 IIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKY 295

Query: 306 TSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQG 365
           TSALT+DA+ V+ EAFR LR+QR+++SRRG+AGDCLANPAVPW QG++IERALK VQV+G
Sbjct: 296 TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 355

Query: 366 MTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV-PFSDQQISNDSASSENRT 424
           ++GNI+FD  G+R NYTI++ E+K +G RK GYW+E ++ V   ++    ND++  EN+T
Sbjct: 356 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 415

Query: 425 IVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARD 484
           +VVTTILESPYVM KKNHE LEGNERYEGYCVDLA EIAKH   KYKL+IVGDGKYGARD
Sbjct: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475

Query: 485 PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 544
            +TKIWNGMVGELVYG+ADIA+APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535

Query: 545 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFG 604
           FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH E+  E+ R+ QS  +  NEFG
Sbjct: 536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEF-EDGRETQSS-ESTNEFG 593

Query: 605 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 664
           IFNSLWFSLGAFM+QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP
Sbjct: 594 IFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653

Query: 665 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVAR 724
           IESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GVAR
Sbjct: 654 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVAR 713

Query: 725 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLK 784
           VRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGS+L   VNLAVLK
Sbjct: 714 VRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLK 773

Query: 785 LSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALI 844
           L+EQG+LDKLKNKWWYDKGECG+    SK+KTSALSLSNVAGVFYILVGGLGLAM+VALI
Sbjct: 774 LNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALI 833

Query: 845 EFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           EFCYKSRAE+KRMK+ KN QN  P+ + N+QN+ATY+EGYNVYG ESVKI
Sbjct: 834 EFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI 883


>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
           sapiens]
          Length = 836

 Score = 1283 bits (3320), Expect = 0.0
 Identities = 617/830 (74%), Positives = 733/830 (88%), Gaps = 6/830 (0%)

Query: 69  FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPS 128
           F L  H+D+L+ +NSF+VTNAFCSQFSRGVYAIFGFYD+ S+NT+TSFCG LH SF+TPS
Sbjct: 9   FRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPS 68

Query: 129 FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQV 188
           FPTD    FVIQMRP LKGA+LSL+ +Y+W+KF YLYD++RG S LQA++++A +  WQV
Sbjct: 69  FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQV 128

Query: 189 TARSVGNI---KDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY 245
           TA +VGNI   K  + +R + ++++ ++E+R ++DCE +++N I++QV+ +GKH +GYHY
Sbjct: 129 TAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHY 188

Query: 246 MLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKY 305
           ++ANLGFTD  L ++  GGAN++GFQIV+ ++ +V +FI+RW  L+E+E+P A    +KY
Sbjct: 189 IIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKY 248

Query: 306 TSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQG 365
           TSALT+DA+ V+ EAFR LR+QR+++SRRG+AGDCLANPAVPW QG++IERALK VQV+G
Sbjct: 249 TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 308

Query: 366 MTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV-PFSDQQISNDSASSENRT 424
           ++GNI+FD  G+R NYTI++ E+K +G RK GYW+E ++ V   ++    ND++  EN+T
Sbjct: 309 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 368

Query: 425 IVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARD 484
           +VVTTILESPYVM KKNHE LEGNERYEGYCVDLA EIAKH   KYKL+IVGDGKYGARD
Sbjct: 369 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 428

Query: 485 PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 544
            +TKIWNGMVGELVYG+ADIA+APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV
Sbjct: 429 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 488

Query: 545 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFG 604
           FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH E+  E+ R+ QS  +  NEFG
Sbjct: 489 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEF-EDGRETQSS-ESTNEFG 546

Query: 605 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 664
           IFNSLWFSLGAFM+QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP
Sbjct: 547 IFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 606

Query: 665 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVAR 724
           IESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GVAR
Sbjct: 607 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVAR 666

Query: 725 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLK 784
           VRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGS+L TPVNLAVLK
Sbjct: 667 VRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLK 726

Query: 785 LSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALI 844
           LSEQG+LDKLKNKWWYDKGECGAKDSGSK+KTSALSLSNVAGVFYILVGGLGLAM+VALI
Sbjct: 727 LSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALI 786

Query: 845 EFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI 894
           EFCYKSRAE+KRMK+ KN QN  P+ + N+QN+ATY+EGYNVYG ESVKI
Sbjct: 787 EFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI 836


>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
           sapiens]
          Length = 906

 Score = 1200 bits (3104), Expect = 0.0
 Identities = 595/844 (70%), Positives = 698/844 (82%), Gaps = 12/844 (1%)

Query: 17  FLVLGLLGHSHGG-FPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHV 75
           F   G LG   G  FPN I IGGLF     QEH+AFRFA+         TE P  L   +
Sbjct: 7   FFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALS------QLTEPP-KLLPQI 59

Query: 76  DHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADV 135
           D ++ S+SF +T  FCSQFS+GVYAIFGFY++ ++N LTSFCGALH  F+TPSFP D   
Sbjct: 60  DIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSN 119

Query: 136 QFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN 195
           QFV+Q+RP L+ A++S++ HYKW+KFVY+YD +RG S+LQ +++ A + NWQVTA ++  
Sbjct: 120 QFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILT 179

Query: 196 IKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDI 255
             + + +R + +++++++E+  ++DCE ER+N IL Q++ L K+  GYHY+LANLGF DI
Sbjct: 180 TTE-EGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDI 238

Query: 256 LLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAIL 315
            L +    GAN+TGFQ+VN  + +  + +Q+W   D R+         KYTSALT+D + 
Sbjct: 239 DLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVK 298

Query: 316 VIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375
           V+AEAF+ LRRQR+D+SRRG+AGDCLANPAVPW QGIDI+RAL+ V+ +G+TGN+QF+  
Sbjct: 299 VMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEK 358

Query: 376 GRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFS-DQQISNDSASSENRTIVVTTILESP 434
           GRRTNYT+ V EMK  G RK GYWNE ++FVP + D Q   D++S +NRT +VTTILE P
Sbjct: 359 GRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDP 418

Query: 435 YVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMV 494
           YVM KKN  Q EGN+RYEGYCV+LA EIAKHV   Y+L IV DGKYGARDP+TK WNGMV
Sbjct: 419 YVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMV 478

Query: 495 GELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 554
           GELVYGRAD+AVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE
Sbjct: 479 GELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 538

Query: 555 IWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLG 614
           IWMCIVFAYIGVSVVLFLVSRFSPYEWH E+  EE RD Q+  D  NEFGIFNSLWFSLG
Sbjct: 539 IWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEF-EEGRD-QTTSDQSNEFGIFNSLWFSLG 596

Query: 615 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 674
           AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656

Query: 675 TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAF 734
           TEIAYGTL++GSTKEFFRRSKIAV+EKMW+YMKSAEPSVF +TT +G+ RVRKSKGK+A+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716

Query: 735 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKL 794
           LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGSAL  PVNLAVLKLSEQG+LDKL
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKL 776

Query: 795 KNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAES 854
           K+KWWYDKGECG+KDSGSKDKTSALSLSNVAGVFYIL+GGLGLAM+VALIEFCYKSR+ES
Sbjct: 777 KSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836

Query: 855 KRMK 858
           KRMK
Sbjct: 837 KRMK 840


>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
           sapiens]
          Length = 906

 Score = 1191 bits (3082), Expect = 0.0
 Identities = 591/844 (70%), Positives = 694/844 (82%), Gaps = 12/844 (1%)

Query: 17  FLVLGLLGHSHGG-FPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHV 75
           F   G LG   G  FPN I IGGLF     QEH+AFRFA+         TE P  L   +
Sbjct: 7   FFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALS------QLTEPP-KLLPQI 59

Query: 76  DHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADV 135
           D ++ S+SF +T  FCSQFS+GVYAIFGFY++ ++N LTSFCGALH  F+TPSFP D   
Sbjct: 60  DIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSN 119

Query: 136 QFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN 195
           QFV+Q+RP L+ A++S++ HYKW+KFVY+YD +RG S+LQ +++ A + NWQVTA ++  
Sbjct: 120 QFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILT 179

Query: 196 IKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDI 255
             + + +R + +++++++E+  ++DCE ER+N IL Q++ L K+  GYHY+LANLGF DI
Sbjct: 180 TTE-EGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDI 238

Query: 256 LLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAIL 315
            L +    GAN+TGFQ+VN  + +  + +Q+W   D R+         KYTSALT+D + 
Sbjct: 239 DLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVK 298

Query: 316 VIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375
           V+AEAF+ LRRQR+D+SRRG+AGDCLANPAVPW QGIDI+RAL+ V+ +G+TGN+QF+  
Sbjct: 299 VMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEK 358

Query: 376 GRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFS-DQQISNDSASSENRTIVVTTILESP 434
           GRRTNYT+ V EMK  G RK GYWNE ++FVP + D Q   D++S +NRT +VTTILE P
Sbjct: 359 GRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDP 418

Query: 435 YVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMV 494
           YVM KKN  Q EGN+RYEGYCV+LA EIAKHV   Y+L IV DGKYGARDP+TK WNGMV
Sbjct: 419 YVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMV 478

Query: 495 GELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 554
           GELVYGRAD+AVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE
Sbjct: 479 GELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 538

Query: 555 IWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLG 614
           IWMCIVFAYIGVSVVLFLVSRFSPYEWH E+  EE RD Q+  D  NEFGIFNSLWFSLG
Sbjct: 539 IWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEF-EEGRD-QTTSDQSNEFGIFNSLWFSLG 596

Query: 615 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 674
           AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656

Query: 675 TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAF 734
           TEIAYGTL++GSTKEFFRRSKIAV+EKMW+YMKSAEPSVF +TT +G+ RVRKSKGK+A+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716

Query: 735 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKL 794
           LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGSAL  PVNLAVLKL+EQG+LDKL
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKL 776

Query: 795 KNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAES 854
           KNKWWYDKGECG+    SKDKTSALSLSNVAGVFYIL+GGLGLAM+VALIEFCYKSR+ES
Sbjct: 777 KNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836

Query: 855 KRMK 858
           KRMK
Sbjct: 837 KRMK 840


>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
           precursor [Homo sapiens]
          Length = 908

 Score =  611 bits (1576), Expect = e-175
 Identities = 359/875 (41%), Positives = 517/875 (59%), Gaps = 51/875 (5%)

Query: 7   MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60
           +   V R    L+L LL  G+S G   + +  GG+F          E  AFRFAV   N 
Sbjct: 8   LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66

Query: 61  NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116
           N+    NTT     L Y    ++  +SF  +   C Q S GV AIFG     S N + S 
Sbjct: 67  NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121

Query: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170
           C AL    +   +    +D    F + + P   +L  AIL L+  +KW+    +YD   G
Sbjct: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181

Query: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230
              LQ +++A  + N ++  R +    D ++ + +++EM R +E   + DC  E    IL
Sbjct: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239

Query: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288
           +Q + +G  +  YHY+   L    + +E   + G N+TGF+I+N EN  V   I++W   
Sbjct: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299

Query: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346
           RL     P++   +  +   +AL +DA+ V++ A +   +  V      S+  C  N   
Sbjct: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351

Query: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405
           PW  G      +K    +G+TG I F+ T G RT++ +DV  +K  G  K G W+     
Sbjct: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411

Query: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
                Q+   +N + S  NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL  E++
Sbjct: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471

Query: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
             +   Y++ +V DGKYGA+D     WNGMV EL+  +AD+AVAPL IT VRE+VIDFSK
Sbjct: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531

Query: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
           PFM+LGISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ 
Sbjct: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590

Query: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
              N  P +P S     N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646

Query: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
           IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW
Sbjct: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706

Query: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
           ++M S   SV  K+  +G+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKG
Sbjct: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763

Query: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823
           YGV TP GS     + +A+L+L E+G L  +K KWW   G C  ++S    + SAL + N
Sbjct: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQN 819

Query: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858
           + G+F +L  GL L++ VA+ EF YKS+  ++  K
Sbjct: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854


>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
           precursor [Homo sapiens]
          Length = 869

 Score =  611 bits (1576), Expect = e-175
 Identities = 359/875 (41%), Positives = 517/875 (59%), Gaps = 51/875 (5%)

Query: 7   MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60
           +   V R    L+L LL  G+S G   + +  GG+F          E  AFRFAV   N 
Sbjct: 8   LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66

Query: 61  NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116
           N+    NTT     L Y    ++  +SF  +   C Q S GV AIFG     S N + S 
Sbjct: 67  NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121

Query: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170
           C AL    +   +    +D    F + + P   +L  AIL L+  +KW+    +YD   G
Sbjct: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181

Query: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230
              LQ +++A  + N ++  R +    D ++ + +++EM R +E   + DC  E    IL
Sbjct: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239

Query: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288
           +Q + +G  +  YHY+   L    + +E   + G N+TGF+I+N EN  V   I++W   
Sbjct: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299

Query: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346
           RL     P++   +  +   +AL +DA+ V++ A +   +  V      S+  C  N   
Sbjct: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351

Query: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405
           PW  G      +K    +G+TG I F+ T G RT++ +DV  +K  G  K G W+     
Sbjct: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411

Query: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
                Q+   +N + S  NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL  E++
Sbjct: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471

Query: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
             +   Y++ +V DGKYGA+D     WNGMV EL+  +AD+AVAPL IT VRE+VIDFSK
Sbjct: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531

Query: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
           PFM+LGISI+ +KP  + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ 
Sbjct: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590

Query: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
              N  P +P S     N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646

Query: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
           IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T  FF++SKI+ Y+KMW
Sbjct: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706

Query: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
           ++M S   SV  K+  +G+ RV  S   +AFL+EST  E++ QR  C+  ++GG +DSKG
Sbjct: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763

Query: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823
           YGV TP GS     + +A+L+L E+G L  +K KWW   G C  ++S    + SAL + N
Sbjct: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQN 819

Query: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858
           + G+F +L  GL L++ VA+ EF YKS+  ++  K
Sbjct: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854


>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
           precursor [Homo sapiens]
          Length = 905

 Score =  600 bits (1546), Expect = e-171
 Identities = 347/846 (41%), Positives = 507/846 (59%), Gaps = 57/846 (6%)

Query: 31  PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
           P  + IGG+F   TV+      E  AF+FAV   N N+    NTT     L Y +  ++ 
Sbjct: 34  PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86

Query: 81  SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
            +SF  +   C Q + GV A+FG     S++ + S C AL    +   +     D    F
Sbjct: 87  FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146

Query: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
            I + P   A+  AIL L+ +Y W+    +Y+   G   LQ +++A  + N ++  R + 
Sbjct: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206

Query: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
            GN    ++ + +++EM + +E   + DC  E    IL+Q++ +G  +  YHY    L  
Sbjct: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262

Query: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
             + LE   + G N+TGF+++N +NP V   I++W   RL     PE    +  +   +A
Sbjct: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322

Query: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
           L +DA+ ++A A    R  ++ VS          +   PW  G      +K  +  G+TG
Sbjct: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374

Query: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENRTI 425
           +I F+ T G R ++ +D+  +K  G+ K G WN          +  + SN + S  NRT+
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434

Query: 426 VVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDP 485
           +VTTILE PYVMY+K+ + L GN+R+EGYC+DL  E++  +   Y + +V DGKYGA++ 
Sbjct: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494

Query: 486 ETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 545
           + + WNGMV EL+  RAD+AVAPLTIT VRE+VIDFSKPFM+LGISI+ +KP  + PGVF
Sbjct: 495 KGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553

Query: 546 SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGI 605
           SFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+    N  P +P S     N F +
Sbjct: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHPCNPDSDV-VENNFTL 608

Query: 606 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 665
            NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI
Sbjct: 609 LNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 668

Query: 666 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARV 725
           +SA+DLAKQT+I YG +  GST  FF++SKI+ YEKMW++M S + +   + + +G+ RV
Sbjct: 669 DSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRV 728

Query: 726 RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKL 785
             +   +A L+EST  EY+ QR  C+  ++GG +DSKGYGV TP GS     + +A+L+L
Sbjct: 729 LTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQL 785

Query: 786 SEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845
            E+G L  +K KWW   G C  +D+    + SAL + N+ G+F +L  GL L++ VA+ E
Sbjct: 786 QEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIVLAAGLVLSVFVAIGE 841

Query: 846 FCYKSR 851
           F YKSR
Sbjct: 842 FIYKSR 847


>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
           precursor [Homo sapiens]
          Length = 918

 Score =  592 bits (1525), Expect = e-169
 Identities = 348/861 (40%), Positives = 508/861 (59%), Gaps = 72/861 (8%)

Query: 31  PNTISIGGLFMRNTVQ------EHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVDHLDS 80
           P  + IGG+F   TV+      E  AF+FAV   N N+    NTT     L Y +  ++ 
Sbjct: 34  PQVLRIGGIF--ETVENEPVNVEELAFKFAVTSINRNRTLMPNTT-----LTYDIQRINL 86

Query: 81  SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP---TDADVQF 137
            +SF  +   C Q + GV A+FG     S++ + S C AL    +   +     D    F
Sbjct: 87  FDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146

Query: 138 VIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSV- 193
            I + P   A+  AIL L+ +Y W+    +Y+   G   LQ +++A  + N ++  R + 
Sbjct: 147 YINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLP 206

Query: 194 -GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGF 252
            GN    ++ + +++EM + +E   + DC  E    IL+Q++ +G  +  YHY    L  
Sbjct: 207 SGN----KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262

Query: 253 TDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV--RLDEREFPEAK--NAPLKYTSA 308
             + LE   + G N+TGF+++N +NP V   I++W   RL     PE    +  +   +A
Sbjct: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322

Query: 309 LTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTG 368
           L +DA+ ++A A    R  ++ VS          +   PW  G      +K  +  G+TG
Sbjct: 323 LMYDAVYMVAIASH--RASQLTVS------SLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374

Query: 369 NIQFD-TYGRRTNYTIDVYEMKVSGSRKA---------------GYWNEYE--RFVPFSD 410
           +I F+ T G R ++ +D+  +K  G+ KA               G WN          + 
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434

Query: 411 QQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKY 470
            + SN + S  NRT++VTTILE PYVMY+K+ + L GN+R+EGYC+DL  E++  +   Y
Sbjct: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494

Query: 471 KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGI 530
            + +V DGKYGA++ + + WNGMV EL+  RAD+AVAPLTIT VRE+VIDFSKPFM+LGI
Sbjct: 495 DVKLVPDGKYGAQNDKGE-WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553

Query: 531 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEP 590
           SI+ +KP  + PGVFSFL+PL+ +IWM ++ A +GVS VLF+++RF+PYEW+    N  P
Sbjct: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWY----NPHP 609

Query: 591 RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 650
            +P S     N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 610 CNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 668

Query: 651 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAE 710
           NLAAFLTVERM SPI+SA+DLAKQT+I YG +  GST  FF++SKI+ YEKMW++M S +
Sbjct: 669 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728

Query: 711 PSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 770
            +   + + +G+ RV  +   +A L+EST  EY+ QR  C+  ++GG +DSKGYGV TP 
Sbjct: 729 QTALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPI 785

Query: 771 GSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYI 830
           GS     + +A+L+L E+G L  +K KWW   G C  +D+    + SAL + N+ G+F +
Sbjct: 786 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEDN---KEASALGVENIGGIFIV 841

Query: 831 LVGGLGLAMMVALIEFCYKSR 851
           L  GL L++ VA+ EF YKSR
Sbjct: 842 LAAGLVLSVFVAIGEFIYKSR 862


>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
           [Homo sapiens]
          Length = 919

 Score =  584 bits (1506), Expect = e-166
 Identities = 335/853 (39%), Positives = 502/853 (58%), Gaps = 55/853 (6%)

Query: 29  GFPNTISIGGLF--------MRNTVQEHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVD 76
           G P+ I IGG+F             +EH AFRF+  + N N+    NTT     L Y + 
Sbjct: 31  GMPHVIRIGGIFEYADGPNAQVMNAEEH-AFRFSANIINRNRTLLPNTT-----LTYDIQ 84

Query: 77  HLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL---HTSFVTPSFPTDA 133
            +   +SF  T   C Q + GV AIFG       N + S C AL   H        P D 
Sbjct: 85  RIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDN 144

Query: 134 DVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
              F + + P   +L  AIL L+ + KW     +YD   G   LQ ++ A  + N ++  
Sbjct: 145 KDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKI 204

Query: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
           R +    D  + R +++EM R +E R + DC       IL+Q + +G  +  YH++   L
Sbjct: 205 RQLPI--DSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTL 262

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT---- 306
               + LE   + G N+TGF+I+N +NP V   +++W     +  P +++  L       
Sbjct: 263 DLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTD 322

Query: 307 SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM 366
           +AL +DA+ +++  ++   +  V+  +      C  + A  W  G      +K  Q +G+
Sbjct: 323 AALLYDAVHIVSVCYQRAPQMTVNSLQ------CHRHKA--WRFGGRFMNFIKEAQWEGL 374

Query: 367 TGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENR 423
           TG I F+ T G RT++ +D+  +K  G  K G W+  +       +  +  N + S  NR
Sbjct: 375 TGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNR 434

Query: 424 TIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGAR 483
           +++VTT+LE P+VM++K+   L GN+R+EGYC+DL  E+A  +   Y++ +V DGKYGA+
Sbjct: 435 SLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQ 494

Query: 484 DPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 543
           D + + WNGMV EL+  +AD+AVAPLTIT VRE+ IDFSKPFM+LG+SI+ +KP  + P 
Sbjct: 495 DDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPS 553

Query: 544 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEF 603
           VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+    +  P +P S     N F
Sbjct: 554 VFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY----DAHPCNPGSEV-VENNF 608

Query: 604 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVS 663
            + NS WF +G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAFLTVERM S
Sbjct: 609 TLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668

Query: 664 PIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVA 723
           PI+SA+DLAKQT+I YG +  G+T  FF++SKI+ +EKMW++M S++PS   K   +G+ 
Sbjct: 669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQ 727

Query: 724 RVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVL 783
           R   +   +A L+EST  EY+ QR  C+  ++GG +DSKGYG+ TP GS     + +A+L
Sbjct: 728 RALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAIL 784

Query: 784 KLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVAL 843
           +L E+  L  +K KWW   G C  +++    + SAL +  + G+F +L  GL L+++VA+
Sbjct: 785 QLQEEDKLHIMKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAAGLVLSVLVAV 840

Query: 844 IEFCYKSRAESKR 856
            EF YK R  ++R
Sbjct: 841 GEFVYKLRKTAER 853


>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
           precursor [Homo sapiens]
          Length = 433

 Score =  546 bits (1407), Expect = e-155
 Identities = 253/422 (59%), Positives = 341/422 (80%), Gaps = 3/422 (0%)

Query: 11  VLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFH 70
           + R +  L  G  G + G FP+++ IGGLF+RNT QE++AFR A+ L+NT+ N +E PF+
Sbjct: 4   ISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFN 63

Query: 71  LNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130
           L  HVD+++++NSF+VTNAFCSQ+SRGV+AIFG YD+ S++TLTSFC ALH S +TPSFP
Sbjct: 64  LVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP 123

Query: 131 TDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
           T+ + QFV+Q+RP+L+GA+LSLL HY+W  FV+LYDT+RG+SILQAIME A QN W V+A
Sbjct: 124 TEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSA 183

Query: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
             V N  DV  +R+++EE+DRRQEK+++IDCE+ER+  ILEQ+V +GKH +GYHY++ANL
Sbjct: 184 ICVENFNDV-SYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALT 310
           GF DI LER +HGGAN+TGFQ+V+   PMV + + RW +LD+RE+P ++  P KYTSALT
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPP-KYTSALT 301

Query: 311 HDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNI 370
           +D +LV+AE FR LRRQ++D+SRRG+AGDCLANPA PW QGID+ER LK V++QG+TGN+
Sbjct: 302 YDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNV 361

Query: 371 QFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSD-QQISNDSASSENRTIVVTT 429
           QFD YGRR NYT+DV+E+K +G RK GYWN+ ++ V   D   + ND+A+ ENRT+VVTT
Sbjct: 362 QFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTT 421

Query: 430 IL 431
           I+
Sbjct: 422 IM 423


>gi|164419739 glutamate receptor, ionotrophic, AMPA 4 isoform 3
           precursor [Homo sapiens]
          Length = 433

 Score =  546 bits (1407), Expect = e-155
 Identities = 253/422 (59%), Positives = 341/422 (80%), Gaps = 3/422 (0%)

Query: 11  VLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFH 70
           + R +  L  G  G + G FP+++ IGGLF+RNT QE++AFR A+ L+NT+ N +E PF+
Sbjct: 4   ISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFN 63

Query: 71  LNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130
           L  HVD+++++NSF+VTNAFCSQ+SRGV+AIFG YD+ S++TLTSFC ALH S +TPSFP
Sbjct: 64  LVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFP 123

Query: 131 TDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
           T+ + QFV+Q+RP+L+GA+LSLL HY+W  FV+LYDT+RG+SILQAIME A QN W V+A
Sbjct: 124 TEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSA 183

Query: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
             V N  DV  +R+++EE+DRRQEK+++IDCE+ER+  ILEQ+V +GKH +GYHY++ANL
Sbjct: 184 ICVENFNDV-SYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALT 310
           GF DI LER +HGGAN+TGFQ+V+   PMV + + RW +LD+RE+P ++  P KYTSALT
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPP-KYTSALT 301

Query: 311 HDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNI 370
           +D +LV+AE FR LRRQ++D+SRRG+AGDCLANPA PW QGID+ER LK V++QG+TGN+
Sbjct: 302 YDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNV 361

Query: 371 QFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSD-QQISNDSASSENRTIVVTT 429
           QFD YGRR NYT+DV+E+K +G RK GYWN+ ++ V   D   + ND+A+ ENRT+VVTT
Sbjct: 362 QFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTT 421

Query: 430 IL 431
           I+
Sbjct: 422 IM 423


>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
          Length = 980

 Score =  528 bits (1359), Expect = e-149
 Identities = 316/818 (38%), Positives = 459/818 (56%), Gaps = 56/818 (6%)

Query: 66  EKPFHLNYHVD--HLDSSNSFSVTNAFCSQFSRGVYAIFG-FYDQMSMNTLTSFCGALHT 122
           E P      VD   L   + +  T+  C    +GV ++ G      S +T++  CG    
Sbjct: 56  EVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEI 115

Query: 123 SFV------TPS-----------FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLY 165
             +      TP            +P++ DV   +           + L   K E  + L 
Sbjct: 116 PHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLE 175

Query: 166 DTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVER 225
           +  RGF I +  +             SV  + D ++   +++E+   +    +ID     
Sbjct: 176 ELVRGFLISKETL-------------SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASI 222

Query: 226 INTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQ 285
            + IL +   LG  S  Y Y+L  + F  + L+ ++   +NI GF + N  +P   +F+ 
Sbjct: 223 SHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFV- 281

Query: 286 RWVRLDEREFPEAKN--APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLAN 343
           R + +  RE  EA     P   ++AL  DA+ V+  A R L R     S+          
Sbjct: 282 RSLNMSWRENCEASTYLGPA-LSAALMFDAVHVVVSAVRELNR-----SQEIGVKPLACT 335

Query: 344 PAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYE 403
            A  W  G  +   L+MV+  G+TG ++F++ G+RTNYT+ + E    G R+ G W    
Sbjct: 336 SANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNR 395

Query: 404 RFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
                +     N S +  N+T+VVTTILE+PYVM + N + L GNER+EG+CVD+  E+A
Sbjct: 396 TLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELA 455

Query: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
           + +R +Y+L +V DG YGA +P    W GMVGEL+  +AD+AVA  TIT  RE+VIDFSK
Sbjct: 456 ELLRFRYRLRLVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSK 514

Query: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
           PFM+LGISI+ +     KPG FSFLDP +  +W+ ++ AY+ VS VLFL +R SPYEW+ 
Sbjct: 515 PFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWY- 573

Query: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
              N  P     P    N++ + NSLWF +G FMQQG +I PR+LS R V GVWW FTLI
Sbjct: 574 ---NPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLI 630

Query: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
           IISSYTANLAAFLTV+RM  P+ESA+DLA QT I YGT+ +GST  FF+ S+   Y++MW
Sbjct: 631 IISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMW 690

Query: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
           +YM+S +PSVF K+T +G+ARV  S  ++AFLLESTMNEY  +R  C+  ++GG LD+KG
Sbjct: 691 NYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKG 747

Query: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823
           YG+  P GS     + LA+L+L E   L+ LK KWW + G C  ++     +   L + N
Sbjct: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPKEED---HRAKGLGMEN 803

Query: 824 VAGVFYILVGGLGLAMMVALIEFCYKSR--AESKRMKL 859
           + G+F +L+ GL +A+ VA++EF + +R  AES+ + +
Sbjct: 804 IGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSV 841


>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
          Length = 956

 Score =  513 bits (1322), Expect = e-145
 Identities = 283/661 (42%), Positives = 405/661 (61%), Gaps = 19/661 (2%)

Query: 192 SVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLG 251
           SV  + D ++   +++E+   +    +I       +TIL +   LG  S  Y Y+  NL 
Sbjct: 190 SVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE 249

Query: 252 FTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTH 311
           F+   ++ ++    NI GF I N  +   Q+F Q   +  +             +SAL  
Sbjct: 250 FSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLF 309

Query: 312 DAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQ 371
           DA+  +  A + L R +    +  S G      A  W  G  +   L+MV+++G+TG+I+
Sbjct: 310 DAVYAVVTAVQELNRSQEIGVKPLSCGS-----AQIWQHGTSLMNYLRMVELEGLTGHIE 364

Query: 372 FDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTIL 431
           F++ G+R+NY + + +   +G R+ G W+  E     S    SN S +  N T+VVTTIL
Sbjct: 365 FNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTIL 424

Query: 432 ESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IW 490
           E+PY+M K NH+++EGN+RYEG+CVD+  E+A+ +R  YK+ +VGDG YG   PE    W
Sbjct: 425 ENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGV--PEANGTW 482

Query: 491 NGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 550
            GMVGEL+  +AD+AVA LTIT  RE+VIDFSKPFM+LGISI+ +     KPG FSFLDP
Sbjct: 483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDP 542

Query: 551 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLW 610
            +  +W+ ++ AY+ VS VLFLV+R +PYEW+      + R         N++ + NSLW
Sbjct: 543 FSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV----NQYSLGNSLW 598

Query: 611 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 670
           F +G FMQQG  I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM  PIES +D
Sbjct: 599 FPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDD 658

Query: 671 LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKG 730
           LA QT I YGT+  GS+  FF+ S+   Y++MW+YM S +PSVF K+T +G+ARV  S  
Sbjct: 659 LADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716

Query: 731 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGI 790
            +AFLLESTMNEY  QR  C+  ++GG LD+KGYG+  P GS      +LA+L+L E   
Sbjct: 717 NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775

Query: 791 LDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKS 850
           L+ LK KWW + G+C  ++     +   L + N+ G+F +L+ GL +A+ +A++EF +  
Sbjct: 776 LEILKRKWW-EGGKCPKEED---HRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831

Query: 851 R 851
           R
Sbjct: 832 R 832


>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
          Length = 1007

 Score =  340 bits (871), Expect = 5e-93
 Identities = 242/869 (27%), Positives = 422/869 (48%), Gaps = 80/869 (9%)

Query: 34  ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNT--TEKPFHLNYHVDHLDSSNSFSVTNAFC 91
           I IG +F  +  ++   FR AV   N N+    TEK   + + V  +D +N F      C
Sbjct: 27  IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEK---ITFSVTFVDGNNPFQAVQEAC 83

Query: 92  SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV-----TPSFP--------TDADVQFV 138
              ++G+ A+       S  +L S   A+H   +     T   P        ++ +  + 
Sbjct: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143

Query: 139 IQMRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN- 195
           + +RP   L   IL ++  Y W+KF+  YD+E     +Q  ++   Q    V  + V N 
Sbjct: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203

Query: 196 ----IKDVQEFRRIIEEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLAN 249
               I  + +  RI EE++R ++  +R ++        + + +VV     +   H+++ N
Sbjct: 204 INKMITTLFDTMRI-EELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIIN 262

Query: 250 LGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER--------EFPEAKNA 301
               D+ ++ ++    +I    I+    P+ Q   QR  R + R        + P A+N 
Sbjct: 263 EEINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQN- 319

Query: 302 PLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMV 361
            ++ ++   +D +L++A AF      R   S    +  C+   + PW  G  +   +K  
Sbjct: 320 -MEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKG 376

Query: 362 QVQGMTGNIQFDTYGRRTNYTIDVY-----EMKVSGSRKAGYWNEYERFV-PFSDQQISN 415
            V G+TG ++F   G   N   ++      E    G RK G WN         +D+++ N
Sbjct: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436

Query: 416 DSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIV 475
           +      R   V T+LE P+VM  +N   L   ++Y+G+ +D+   ++ ++   Y++ + 
Sbjct: 437 NMRGVVLR---VVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVA 491

Query: 476 GDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIK 535
            D KYG+   E   WNG+VGELV+ RADI ++ LTIT  RE V+DF+  +M   + ++++
Sbjct: 492 PDHKYGSPQ-EDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550

Query: 536 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQS 595
           + +K+   +F+ L P    +W CI    + V ++++L++  +P              P+ 
Sbjct: 551 RAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP--------------PRL 595

Query: 596 PPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 655
                    ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLAAF
Sbjct: 596 QMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAF 655

Query: 656 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI------AVYEKMWSYMKSA 709
           LT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +      ++Y +MW  +  +
Sbjct: 656 LTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRS 715

Query: 710 EPSVFTKTTADGVARVRKSK-GKFAFLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGVA 767
             S       +  A ++K K G +AF+ ++ + EY+    P C    +G  +  +GYG+A
Sbjct: 716 NGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIA 773

Query: 768 TPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDS-GSKDKTSALSLSNVAG 826
              GS      +  +L+L + G +D LK+KWW   G+C    S  +K K  AL + + AG
Sbjct: 774 LQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAG 833

Query: 827 VFYILVGGLGLAMMVALIEFCYKSRAESK 855
           VF IL  G+ L+  +A++E  +  R  S+
Sbjct: 834 VFCILAAGIVLSCFIAMLETWWNKRKGSR 862


>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
           sapiens]
          Length = 1009

 Score =  327 bits (838), Expect = 3e-89
 Identities = 246/861 (28%), Positives = 415/861 (48%), Gaps = 71/861 (8%)

Query: 34  ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQ 93
           I IG +F  N  ++   F+ AV   + N +  +    + Y +  ++++N F      C  
Sbjct: 24  IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEACDL 82

Query: 94  FSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV--------TPSF-----PTDADVQFVIQ 140
            ++G+ A+       S N L S   A+H   +        +P       P+     + + 
Sbjct: 83  MTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLA 142

Query: 141 MRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVG-NIK 197
            RP   L   +L L+   +W+KFV  YD+E     LQ+ ++ A +    V+ + V  NI 
Sbjct: 143 SRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNIS 202

Query: 198 DVQEFRRII-----EEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
            V  F  +      EE++R ++  +R ++    +  ++ + + V     S+  H++  N 
Sbjct: 203 HV--FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260

Query: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER------EFPEAKNAPLK 304
             +D  +  ++H    +    +V    P  +   Q+  R + R      +  E     L+
Sbjct: 261 EISDPEILDLVHSA--LGRMTVVRQIFPSAKDN-QKCTRNNHRISSLLCDPQEGYLQMLQ 317

Query: 305 YTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAG-DCLANPAVPWSQGIDIERALKMVQV 363
            ++   +D++L++A AF    R+  D      A  +C+     PW+ G  +   +K   +
Sbjct: 318 ISNLYLYDSVLMLANAFH---RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHI 374

Query: 364 QGMTGNIQFDTYGRRTNYTIDVYEMKVSGS-----RKAGYWNEYERFVPFSDQQISNDSA 418
            G+TG ++F           ++     S +     RK   W+  E+ +  S Q+    S 
Sbjct: 375 TGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS-EKGLNGSLQERPMGSR 433

Query: 419 SSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDG 478
             +  T+ V T+LE P+VM  +N   L   +RY+G+ +D+   +AK +  KY++    DG
Sbjct: 434 L-QGLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDG 490

Query: 479 KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 538
           +YG +   T  WNGM+GEL+  RAD+A++ +TIT  RE V+DFSK +M   + I+IKKP+
Sbjct: 491 RYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE 549

Query: 539 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD 598
           + K  +FS   P  + +W CI  A   V V++F+++R                   + P 
Sbjct: 550 E-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR----------AQSAAQPR 598

Query: 599 PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 658
           P     + +++W   GAF+QQG + S  S++ RIV G WW FTLI+ SSYTANLAAFLTV
Sbjct: 599 PSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658

Query: 659 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR------SKIAVYEKMW-SYMKSAEP 711
            RM +PI + +DL+KQ E++YGT+   +  E+FR        + + + ++W +  K+   
Sbjct: 659 SRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718

Query: 712 SVFTKTTADGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVATPK 770
                + ++G+ + +  KG +AFL +  + EY       C    +G ++ SKGYG+A   
Sbjct: 719 DNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQH 776

Query: 771 GSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKT-SALSLSNVAGVFY 829
           GS      +  +L+L + G LD LK KWW   G C      S      +L L + AGVF 
Sbjct: 777 GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836

Query: 830 ILVGGLGLAMMVALIEFCYKS 850
           IL  GL LA +VA +E  + S
Sbjct: 837 ILAIGLLLACLVAALELWWNS 857


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score =  225 bits (574), Expect = 1e-58
 Identities = 187/777 (24%), Positives = 339/777 (43%), Gaps = 115/777 (14%)

Query: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215
           Y W   + L   +      Q  +E  ++       + +      +    ++ E    + +
Sbjct: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217

Query: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275
             ++    +   T+     +L     GY +++   G  +I    + +    I G Q++N 
Sbjct: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274

Query: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334
           +N                             SA   DA+ V+A+A    L ++ +    R
Sbjct: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306

Query: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393
           G    C+ N  + W  G   +R L   +   G+TG ++F+  G R      +  ++    
Sbjct: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361

Query: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441
            + G +N       +R + +   +         +  + + TI + P+V  K         
Sbjct: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421

Query: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477
                             ++   G+ R+       G+C+DL  ++A+ +   Y++ +V D
Sbjct: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481

Query: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
           GK+G ++       K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G++I+
Sbjct: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541

Query: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
           +KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+     ++ EE  D 
Sbjct: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652
            +         + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SYTANL
Sbjct: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651

Query: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709
           AAFL ++R    I    D   +    +  Y T+   S   +FRR        M+ +M+  
Sbjct: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709

Query: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769
                 ++ A+ +  VR +K   AF+ +S + E+ E  + CD +  G      G+G+   
Sbjct: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763

Query: 770 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 829
           K S     V+L++LK  E G ++ L +K W    EC ++ +      + L+  N+AGVF 
Sbjct: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMAGVFM 818

Query: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL----------TKNTQNFKPAPATNTQN 876
           ++ GG+   + +  IE  YK   +++R ++           KN Q + P   T   N
Sbjct: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQQYHPTDITGPLN 875


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score =  222 bits (566), Expect = 1e-57
 Identities = 181/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)

Query: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215
           Y W   + L   +      Q  +E  ++       + +      +    ++ E    + +
Sbjct: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217

Query: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275
             ++    +   T+     +L     GY +++   G  +I    + +    I G Q++N 
Sbjct: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274

Query: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334
           +N                             SA   DA+ V+A+A    L ++ +    R
Sbjct: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306

Query: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393
           G    C+ N  + W  G   +R L   +   G+TG ++F+  G R      +  ++    
Sbjct: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361

Query: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441
            + G +N       +R + +   +         +  + + TI + P+V  K         
Sbjct: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421

Query: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477
                             ++   G+ R+       G+C+DL  ++A+ +   Y++ +V D
Sbjct: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481

Query: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
           GK+G ++       K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G++I+
Sbjct: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541

Query: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
           +KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+     ++ EE  D 
Sbjct: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652
            +         + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SYTANL
Sbjct: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651

Query: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709
           AAFL ++R    I    D   +    +  Y T+   S   +FRR        M+ +M+  
Sbjct: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709

Query: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769
                 ++ A+ +  VR +K   AF+ +S + E+ E  + CD +  G      G+G+   
Sbjct: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763

Query: 770 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 829
           K S     V+L++LK  E G ++ L +K W    EC ++ +      + L+  N+AGVF 
Sbjct: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMAGVFM 818

Query: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859
           ++ GG+   + +  IE  YK   +++R ++
Sbjct: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score =  222 bits (566), Expect = 1e-57
 Identities = 181/750 (24%), Positives = 332/750 (44%), Gaps = 105/750 (14%)

Query: 156 YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK 215
           Y W   + L   +      Q  +E  ++       + +      +    ++ E    + +
Sbjct: 158 YSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEAR 217

Query: 216 RYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNN 275
             ++    +   T+     +L     GY +++   G  +I    + +    I G Q++N 
Sbjct: 218 VIILSASEDDAATVYRAAAMLNMTGSGYVWLV---GEREISGNALRYAPDGILGLQLING 274

Query: 276 ENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR-YLRRQRVDVSRR 334
           +N                             SA   DA+ V+A+A    L ++ +    R
Sbjct: 275 KNE----------------------------SAHISDAVGVVAQAVHELLEKENITDPPR 306

Query: 335 GSAGDCLANPAVPWSQGIDIERALKMVQ-VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGS 393
           G    C+ N  + W  G   +R L   +   G+TG ++F+  G R      +  ++    
Sbjct: 307 G----CVGNTNI-WKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKL 361

Query: 394 RKAGYWN-----EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKN------- 441
            + G +N       +R + +   +         +  + + TI + P+V  K         
Sbjct: 362 VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCK 421

Query: 442 ------------------HEQLEGNERYE------GYCVDLAYEIAKHVRIKYKLSIVGD 477
                             ++   G+ R+       G+C+DL  ++A+ +   Y++ +V D
Sbjct: 422 EEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVAD 481

Query: 478 GKYGARD----PETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
           GK+G ++       K WNGM+GEL+ G+AD+ VAPLTI   R + I+FSKPF   G++I+
Sbjct: 482 GKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 541

Query: 534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
           +KK +  +  + SF+ P    +W+ +  +   V+V+L+L+ RFSP+     ++ EE  D 
Sbjct: 542 VKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA 600

Query: 594 QSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANL 652
            +         + +++WFS G  +  G  + +PRS S RI+G VW  F +II++SYTANL
Sbjct: 601 LT---------LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANL 651

Query: 653 AAFLTVERMVSPIESAEDLAKQT---EIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 709
           AAFL ++R    I    D   +    +  Y T+   S   +FRR        M+ +M+  
Sbjct: 652 AAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKH 709

Query: 710 EPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 769
                 ++ A+ +  VR +K   AF+ +S + E+ E  + CD +  G      G+G+   
Sbjct: 710 N----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMR 763

Query: 770 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFY 829
           K S     V+L++LK  E G ++ L +K W    EC ++ +      + L+  N+AGVF 
Sbjct: 764 KDSPWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNA----PATLTFENMAGVFM 818

Query: 830 ILVGGLGLAMMVALIEFCYKSRAESKRMKL 859
           ++ GG+   + +  IE  YK   +++R ++
Sbjct: 819 LVAGGIVAGIFLIFIEIAYKRHKDARRKQM 848


>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
           [Homo sapiens]
          Length = 1484

 Score =  179 bits (453), Expect = 1e-44
 Identities = 132/408 (32%), Positives = 207/408 (50%), Gaps = 42/408 (10%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+  +I+K V+  Y L +V +GK+G +   T  WNGM+GE+V  RA +AV  LTI
Sbjct: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTI 515

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R EV+DFS PF+  GIS+M+ +         +FL+P + ++W M  V   I  +V +
Sbjct: 516 NEERSEVVDFSVPFIETGISVMVSR-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAV 574

Query: 571 FLVSRFSP--YEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRS 627
           F+   FSP  Y   L D     R+P  P      F I  ++W   G        + +P+ 
Sbjct: 575 FVFEYFSPVGYNRCLADG----REPGGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKG 625

Query: 628 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGT 681
            + +I+  VW FF +I ++SYTANLAAF+  E  V  +    D   Q          +GT
Sbjct: 626 TTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGT 685

Query: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMN 741
           + +GST+   R +    Y +M +YM       F +   D      K+    AF+ ++ + 
Sbjct: 686 VPNGSTERNIRNN----YAEMHAYM-----GKFNQRGVDDALLSLKTGKLDAFIYDAAVL 736

Query: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKW 798
            Y+  R + C  + +G      S GYG+A  K S     V+LA+L+L   G +++L+  W
Sbjct: 737 NYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW 796

Query: 799 WYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF 846
               G C   +  ++  +S L + N+AGVFY+    LG AM ++LI F
Sbjct: 797 L--TGIC--HNEKNEVMSSQLDIDNMAGVFYM----LGAAMALSLITF 836


>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
           precursor [Homo sapiens]
          Length = 1281

 Score =  177 bits (448), Expect = 5e-44
 Identities = 125/411 (30%), Positives = 207/411 (50%), Gaps = 40/411 (9%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+  ++++ V+  Y L +V +GK+G +     +WNGM+GE+VY RA +AV  LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTI 514

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R EV+DFS PF+  GIS+M+ +         +FL+P +  +W M  V   I  ++ +
Sbjct: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573

Query: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
           F+   FSP  ++   N  + + P  P      F I  ++W   G        + +P+  +
Sbjct: 574 FVFEYFSPVGYN--RNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 626

Query: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
            +I+  VW FF +I ++SYTANLAAF+  E  V  +    D   Q          +GT+ 
Sbjct: 627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP 686

Query: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV--ARVRKSKGKF-AFLLESTM 740
           +GST+   R +    Y  M  YM        TK    GV  A V    GK  AF+ ++ +
Sbjct: 687 NGSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAV 734

Query: 741 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK 797
             Y   R + C  + +G      + GYG+A  KGS     ++LA+L+    G +++L+  
Sbjct: 735 LNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794

Query: 798 WWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
           W    G C   +  ++  +S L + N+AGVFY+L   + L+++  + E  +
Sbjct: 795 WL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  177 bits (448), Expect = 5e-44
 Identities = 125/411 (30%), Positives = 207/411 (50%), Gaps = 40/411 (9%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+  ++++ V+  Y L +V +GK+G +     +WNGM+GE+VY RA +AV  LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTI 514

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R EV+DFS PF+  GIS+M+ +         +FL+P +  +W M  V   I  ++ +
Sbjct: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573

Query: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
           F+   FSP  ++   N  + + P  P      F I  ++W   G        + +P+  +
Sbjct: 574 FVFEYFSPVGYN--RNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 626

Query: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
            +I+  VW FF +I ++SYTANLAAF+  E  V  +    D   Q          +GT+ 
Sbjct: 627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP 686

Query: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV--ARVRKSKGKF-AFLLESTM 740
           +GST+   R +    Y  M  YM        TK    GV  A V    GK  AF+ ++ +
Sbjct: 687 NGSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAV 734

Query: 741 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK 797
             Y   R + C  + +G      + GYG+A  KGS     ++LA+L+    G +++L+  
Sbjct: 735 LNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794

Query: 798 WWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
           W    G C   +  ++  +S L + N+AGVFY+L   + L+++  + E  +
Sbjct: 795 WL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  177 bits (448), Expect = 5e-44
 Identities = 125/411 (30%), Positives = 207/411 (50%), Gaps = 40/411 (9%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+  ++++ V+  Y L +V +GK+G +     +WNGM+GE+VY RA +AV  LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTI 514

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R EV+DFS PF+  GIS+M+ +         +FL+P +  +W M  V   I  ++ +
Sbjct: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573

Query: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
           F+   FSP  ++   N  + + P  P      F I  ++W   G        + +P+  +
Sbjct: 574 FVFEYFSPVGYN--RNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 626

Query: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
            +I+  VW FF +I ++SYTANLAAF+  E  V  +    D   Q          +GT+ 
Sbjct: 627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP 686

Query: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV--ARVRKSKGKF-AFLLESTM 740
           +GST+   R +    Y  M  YM        TK    GV  A V    GK  AF+ ++ +
Sbjct: 687 NGSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAV 734

Query: 741 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK 797
             Y   R + C  + +G      + GYG+A  KGS     ++LA+L+    G +++L+  
Sbjct: 735 LNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794

Query: 798 WWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
           W    G C   +  ++  +S L + N+AGVFY+L   + L+++  + E  +
Sbjct: 795 WL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841


>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
           [Homo sapiens]
          Length = 1233

 Score =  172 bits (436), Expect = 1e-42
 Identities = 119/401 (29%), Positives = 202/401 (50%), Gaps = 34/401 (8%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+  ++A+ V+  Y L +V +GK+G R     +WNGM+GE+ Y RAD+A+  LTI
Sbjct: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTI 512

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R E++DFS PF+  GIS+M+ +         +FL+P +  +W M  V     V++ +
Sbjct: 513 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITV 571

Query: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
           F+   FSP  ++   N    +    P      F I  S+W            I +PR  +
Sbjct: 572 FMFEYFSPVSYN--QNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPRGTT 624

Query: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
            +I+  VW FF +I ++SYTANLAAF+  E+ +  +    D   Q          +GT+ 
Sbjct: 625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVP 684

Query: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEY 743
           +GST+   R +    Y  M ++M       F + + +      K     AF+ ++ +  Y
Sbjct: 685 NGSTERNIRSN----YRDMHTHMVK-----FNQRSVEDALTSLKMGKLDAFIYDAAVLNY 735

Query: 744 IEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWY 800
           +  + + C  + +G      + GYG+A  K S     ++LA+L+    G   KL+  W  
Sbjct: 736 MAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL- 794

Query: 801 DKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
             G C  ++  ++  +S L + N+AGVFY+L+  +GLA++V
Sbjct: 795 -SGIC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 832


>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
           [Homo sapiens]
          Length = 1336

 Score =  167 bits (424), Expect = 3e-41
 Identities = 121/403 (30%), Positives = 203/403 (50%), Gaps = 38/403 (9%)

Query: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
           +G+C+D+   +A  +   Y L +V +GK+G +     +WNGM+GE+ Y RAD+A+  LTI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDG--VWNGMIGEVFYQRADMAIGSLTI 542

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
              R E++DFS PF+  GIS+M+ +         +FL+P +  +W M  V     V+V +
Sbjct: 543 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601

Query: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
           F+    SP  +     N      + P    + F I  S+W            + +PR  +
Sbjct: 602 FIFEYLSPVGY-----NRSLATGKRPGG--STFTIGKSIWLLWALVFNNSVPVENPRGTT 654

Query: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
            +I+  VW FF +I ++SYTANLAAF+  E  V  +    D   Q        + +GT+ 
Sbjct: 655 SKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVP 714

Query: 684 SGSTKEFFRRSKIAVYEKMWSYM-KSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTMN 741
           +GST++  R +    Y  M SYM +  +P V    T       +   GK  AF+ ++ + 
Sbjct: 715 NGSTEKNIRSN----YPDMHSYMVRYNQPRVEEALT-------QLKAGKLDAFIYDAAVL 763

Query: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKW 798
            Y+ ++ + C  + +G      + GYG+A  KGS    P++LA+L+      ++ L+  W
Sbjct: 764 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLW 823

Query: 799 WYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
               G C   +   +  +S L + N+AGVFY+L+  +GL+++V
Sbjct: 824 L--SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLV 862


>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
           [Homo sapiens]
          Length = 1043

 Score =  157 bits (398), Expect = 3e-38
 Identities = 118/409 (28%), Positives = 203/409 (49%), Gaps = 44/409 (10%)

Query: 453 GYCVDLAYEIAKHVRIKYKLSIVGDGKYGA-RDPETKIWNGMVGELVYGRADIAVAPLTI 511
           GYC+DL   +A+     ++L +VGDGKYGA RD     W G+VG+L+ GRA +AV   +I
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534

Query: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 571
              R +V+DF+ PF S  + IM++    + P + +F+ PL +  W       +GV   L 
Sbjct: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586

Query: 572 LVSRF-SPYEWHLEDNNEEPRDPQS-PPDPPNEFGIFN-----SLWFSLGAFMQQGCDIS 624
           L + F + YEW         R P    P   N   +F+     +L +++  F +     +
Sbjct: 587 LTALFLTVYEW---------RSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKT 636

Query: 625 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGT 681
           P+  +GR++  +W  F L+++SSYTANLAA +  ++    +    D           +GT
Sbjct: 637 PKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGT 696

Query: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTM 740
           +   S + + ++S    +  M ++M+         TT  GVA +     K  AF+++ ++
Sbjct: 697 VWESSAEAYIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSL 748

Query: 741 NEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWW 799
            +Y +     C  + VG     +GYG+  P+ S L + ++  + +    G +D L +K W
Sbjct: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-W 807

Query: 800 YDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
           Y    CG K   +  +T  +S+ + AG+F +L  GLG A++ +L E  +
Sbjct: 808 YKMVPCG-KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,409,923
Number of Sequences: 37866
Number of extensions: 1333051
Number of successful extensions: 3711
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3511
Number of HSP's gapped (non-prelim): 43
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.