Search of human proteins with 16332372

Search of human proteins with 16332372

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins)
isoform 9 [Homo sapiens]
         (771 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1545   0.0  
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1537   0.0  
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1531   0.0  
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]   1521   0.0  
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]   1518   0.0  
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1468   0.0  
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1460   0.0  
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      362   e-100
gi|169161522 PREDICTED: similar to cell division cycle 2-like 1 ...   304   2e-82
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      303   4e-82
gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta S...   298   1e-80
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      290   3e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      288   1e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   271   1e-72
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        270   3e-72
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             254   2e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           252   8e-67
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    248   2e-65
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    248   2e-65
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   246   8e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   246   8e-65
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   241   2e-63
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   240   3e-63
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   240   4e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        239   5e-63
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          239   5e-63
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        234   2e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    230   3e-60
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 229   1e-59

>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 1545 bits (3999), Expect = 0.0
 Identities = 771/771 (100%), Positives = 771/771 (100%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120

Query: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 180
           ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 180

Query: 181 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 240
           KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP
Sbjct: 181 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 240

Query: 241 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESE 300
           VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESE
Sbjct: 241 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESE 300

Query: 301 EEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGES 360
           EEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGES
Sbjct: 301 EEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGES 360

Query: 361 EEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 420
           EEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI
Sbjct: 361 EEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 420

Query: 421 EEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIV 480
           EEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIV
Sbjct: 421 EEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIV 480

Query: 481 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLK 540
           VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLK
Sbjct: 481 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLK 540

Query: 541 TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 600
           TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV
Sbjct: 541 TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 600

Query: 601 GCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNL 660
           GCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNL
Sbjct: 601 GCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNL 660

Query: 661 RKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ 720
           RKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ
Sbjct: 661 RKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ 720

Query: 721 QRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771
           QRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 QRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 1537 bits (3979), Expect = 0.0
 Identities = 771/780 (98%), Positives = 771/780 (98%), Gaps = 9/780 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120

Query: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQLERKRERERKMR 171
           ERRKRHREEQDKARREWERQKRREMAREHSRRER         DRLEQLERKRERERKMR
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMR 180

Query: 172 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 231
           EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER
Sbjct: 181 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 240

Query: 232 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 291
           FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
Sbjct: 241 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 300

Query: 292 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 351
           EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES
Sbjct: 301 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360

Query: 352 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSV 411
           RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSV
Sbjct: 361 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSV 420

Query: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 471
           EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480

Query: 472 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 531
           NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540

Query: 532 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 591
           NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 600

Query: 592 STAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT 651
           STAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT 660

Query: 652 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF 711
           FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF
Sbjct: 661 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF 720

Query: 712 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771
           PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 780


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 1531 bits (3965), Expect = 0.0
 Identities = 770/782 (98%), Positives = 770/782 (98%), Gaps = 11/782 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-----------K 109
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120

Query: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 169
           HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180

Query: 170 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 229
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240

Query: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 289
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300

Query: 290 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 349
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360

Query: 350 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 409
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
Sbjct: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420

Query: 410 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 469
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480

Query: 470 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 529
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540

Query: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600

Query: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
           EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 709
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720

Query: 710 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 769
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780

Query: 770 KF 771
           KF
Sbjct: 781 KF 782


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 1521 bits (3939), Expect = 0.0
 Identities = 764/772 (98%), Positives = 765/772 (99%), Gaps = 3/772 (0%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-KHARVKEKERE 119
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK KHARVKE  RE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE--RE 118

Query: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 179
           HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE
Sbjct: 119 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 178

Query: 180 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 239
           QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK
Sbjct: 179 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 238

Query: 240 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299
           PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES
Sbjct: 239 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 298

Query: 300 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 359
           EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE
Sbjct: 299 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 358

Query: 360 SEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNR 419
           SEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNR
Sbjct: 359 SEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNR 418

Query: 420 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI 479
           IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI
Sbjct: 419 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI 478

Query: 480 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL 539
           VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL
Sbjct: 479 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL 538

Query: 540 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWS 599
           KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWS
Sbjct: 539 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWS 598

Query: 600 VGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNN 659
           VGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNN
Sbjct: 599 VGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNN 658

Query: 660 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE 719
           LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE
Sbjct: 659 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE 718

Query: 720 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771
           QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 719 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1518 bits (3929), Expect = 0.0
 Identities = 764/782 (97%), Positives = 765/782 (97%), Gaps = 13/782 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-----------K 109
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 120

Query: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 169
           HARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 121 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 178

Query: 170 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 229
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 179 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 238

Query: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 289
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 239 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 298

Query: 290 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 349
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 299 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 358

Query: 350 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 409
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCR
Sbjct: 359 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 418

Query: 410 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 469
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 419 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 478

Query: 470 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 529
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 479 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 538

Query: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAK
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 598

Query: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
           EYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKK
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 658

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 709
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 718

Query: 710 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 769
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 719 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 778

Query: 770 KF 771
           KF
Sbjct: 779 KF 780


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 1468 bits (3801), Expect = 0.0
 Identities = 733/737 (99%), Positives = 734/737 (99%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154
           EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 61  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120

Query: 155 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 214
           DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK
Sbjct: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180

Query: 215 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 274
           VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
Sbjct: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240

Query: 275 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 334
           SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS
Sbjct: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300

Query: 335 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 394
           EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL
Sbjct: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360

Query: 395 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 454
           KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF
Sbjct: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420

Query: 455 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 514
           PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE
Sbjct: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480

Query: 515 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 574
           VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV
Sbjct: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540

Query: 575 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
           VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS
Sbjct: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600

Query: 635 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
           EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL
Sbjct: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660

Query: 695 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 754
           KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT
Sbjct: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720

Query: 755 TTNQGASAAGPGFSLKF 771
           TTNQGASAAGPGFSLKF
Sbjct: 721 TTNQGASAAGPGFSLKF 737


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 1460 bits (3779), Expect = 0.0
 Identities = 733/748 (97%), Positives = 734/748 (98%), Gaps = 11/748 (1%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 143
           EKVHHRKDEKRKEK           KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 61  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120

Query: 144 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 203
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180

Query: 204 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 263
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240

Query: 264 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 323
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300

Query: 324 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 383
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360

Query: 384 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 443
           PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 420

Query: 444 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 503
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 421 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 480

Query: 504 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 563
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 481 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 540

Query: 564 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 623
           GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 541 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 600

Query: 624 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 683
           NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 601 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 660

Query: 684 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 743
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 661 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 720

Query: 744 DDLKETGFHLTTTNQGASAAGPGFSLKF 771
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 DDLKETGFHLTTTNQGASAAGPGFSLKF 748


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60

Query: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 365
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120

Query: 366 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 425
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180

Query: 426 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 485
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240

Query: 486 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 545
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300

Query: 546 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 605
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360

Query: 606 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 665
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420

Query: 666 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 725
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480

Query: 726 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 24/192 (12%)

Query: 91  MSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 150
           M  ++ +   +D    E+K +  +    E        EE+++   E           E S
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE-----------EGS 49

Query: 151 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 210
             E           E E +  E+++E+ E       A E+  E  +  E+S       E+
Sbjct: 50  TSE-----------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 98

Query: 211 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 270
           +   V  S + R          E+G+G    +   + E D + D   +S  E K    + 
Sbjct: 99  HLLVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKY 156

Query: 271 SSAESGSGSEEE 282
             A  G  S EE
Sbjct: 157 LPALQGCRSVEE 168



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 28/122 (22%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 71  DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 130
           D + D  +  DS       + S  E     ++E+ +E++     E+E      +   EE+
Sbjct: 5   DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59

Query: 131 DKARREWERQKRREMAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRA 187
           ++   E E     E A E S     E +  E  ER+ E    +  + +  R+  E E   
Sbjct: 60  EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 119

Query: 188 EE 189
           EE
Sbjct: 120 EE 121


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  362 bits (928), Expect = e-100
 Identities = 176/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)

Query: 408 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 467
           CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI  +L+
Sbjct: 33  CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92

Query: 468 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 527
            +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M  PF   +VK +++Q+LRG++
Sbjct: 93  LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152

Query: 528 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLG 587
           +LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P+K  TP VVTLWYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212

Query: 588 AKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAV 647
               +T++DMW+VGCI  ELL  +PL PG SEI QI+ + + LGTPSE IWPG+S+LP V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272

Query: 648 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 707
            + +  + PYNNL+ +F   LS+ G  L++    Y P +R +A D L+  YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331

Query: 708 PSMFPTWPAKSEQQRVKRGTSPRPPEG 734
           P + PT+P      R KR  +P   EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353


>gi|169161522 PREDICTED: similar to cell division cycle 2-like 1
           (PITSLRE proteins) [Homo sapiens]
          Length = 155

 Score =  304 bits (778), Expect = 2e-82
 Identities = 152/155 (98%), Positives = 152/155 (98%), Gaps = 1/155 (0%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-KHARVKEKERE 119
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK HHRKDEKRKEK KHARVKEKERE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRKHARVKEKERE 120

Query: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRER 154
           HERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 121 HERRKRHREEQDKARREWERQKRREMAREHSRRER 155



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 33/168 (19%), Positives = 67/168 (39%), Gaps = 18/168 (10%)

Query: 161 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 220
           E+   + + + E  +E++ +KE+E +AE +R +    R+      + R+   +     H 
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD------SKRDSLEEGELRDH- 56

Query: 221 SRSPPRPPRERFELGDGRKPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 279
                     R E+     P + E+ ME+R    D   I   ++ +   ++   +     
Sbjct: 57  ----------RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRK 106

Query: 280 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 327
           E+ +    +E+E      +   EE+++   E E     E A E S  E
Sbjct: 107 EKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 18/156 (11%)

Query: 157 LEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 216
           L++ +R++E+E K   ++ +  + ++ +R + E  + R+ R E++  +   R + S + +
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76

Query: 217 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 276
                    +PP++           ++EK   R          D +RK     +   E  
Sbjct: 77  GEEDDSLAIKPPQQM---------SRKEKAHHR---------KDEKRKEKRKHARVKEKE 118

Query: 277 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 312
              E  +   EE+++     E  +  E   E    E
Sbjct: 119 REHERRKRHREEQDKARREWERQKRREMAREHSRRE 154


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  303 bits (776), Expect = 4e-82
 Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)

Query: 447 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 506
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 507 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 566
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 567 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 626
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 627 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 686
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 687 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 734
           R +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282


>gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta SV2
           [Homo sapiens]
          Length = 153

 Score =  298 bits (763), Expect = 1e-80
 Identities = 151/155 (97%), Positives = 151/155 (97%), Gaps = 3/155 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-KHARVKEKERE 119
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMS KEKVHHRKDEKRKEK KHARV  KERE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEKWKHARV--KERE 118

Query: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRER 154
           HERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 119 HERRKRHREEQDKARREWERQKRREMAREHSRRER 153



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 34/130 (26%), Positives = 59/130 (45%), Gaps = 6/130 (4%)

Query: 102 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERD--RLEQ 159
           DE  +EKK  + +E++ E +R K + +++D  R   E  + R+   E + R     R + 
Sbjct: 14  DEILQEKKRRKEQEEKAEIKRLK-NSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDS 72

Query: 160 LERKRERERKMREQQKEQREQKER-ERRAEERRKER--EARREVSAHHRTMREDYSDKVK 216
           +E + E +  +  +  +Q   KE+   R +E+RKE+   AR +   H R  R        
Sbjct: 73  MEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKA 132

Query: 217 ASHWSRSPPR 226
              W R   R
Sbjct: 133 RREWERQKRR 142


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  290 bits (743), Expect = 3e-78
 Identities = 145/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)

Query: 447 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 506
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 507 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 566
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 567 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 626
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 627 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 686
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++         
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233

Query: 687 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 734
             +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  288 bits (738), Expect = 1e-77
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 447 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 506
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 507 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 566
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 567 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 626
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 627 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 686
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 687 RISAEDGLKHEYFRETPL 704
           R +A D L+  YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  271 bits (694), Expect = 1e-72
 Identities = 136/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           ++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 529
           PNIV + ++V   N  K+Y+V  ++  DLK  M++     LP   +K+ + QLL+GV   
Sbjct: 61  PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118

Query: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589
           H + ++HRDLK  NLL++  G +K+ DFGLAR +G PL+ YT  VVTLWYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
            Y+TAVD+WS+GCIF E++T+K LFPG SEIDQ+ ++F+ LGTPSE  WPG ++LP  K 
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 699
            +F +     L +     L  +G DL+ + L Y P +RI+A+  L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  270 bits (691), Expect = 3e-72
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 529
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118

Query: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178

Query: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 706
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  254 bits (649), Expect = 2e-67
 Identities = 124/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 524
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 525 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 584
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT  VVTLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174

Query: 585 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 644
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 645 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 701
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  252 bits (644), Expect = 8e-67
 Identities = 122/297 (41%), Positives = 196/297 (65%), Gaps = 14/297 (4%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 524
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 525 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 584
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT   +TLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174

Query: 585 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 644
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 645 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 701
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  248 bits (633), Expect = 2e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 63   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 120
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 121  ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 176
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 177  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 236
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538

Query: 237  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 296
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589

Query: 297  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 356
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634

Query: 357  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 406
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694

Query: 407  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754

Query: 464  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814

Query: 516  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874

Query: 575  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934

Query: 635  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993

Query: 695  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 725
            + E+ R+  P  + P   P W    E    KR
Sbjct: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 93  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 149 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 201
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308

Query: 202 AHHRTM-------RED--YSDKVKASHWSRSPPRP 227
           A+ R         R+D   S +   S  SR  P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 140 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 193
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 194 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 238
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 299 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 359 ES 360
           +S
Sbjct: 408 KS 409



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 62/336 (18%), Positives = 100/336 (29%), Gaps = 35/336 (10%)

Query: 21  KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEED 80
           +RR  ++ ++   R K       +RD    G             S  R   S E+R E  
Sbjct: 195 ERRPRRDRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVA 246

Query: 81  DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQ 140
            S +        +           RK++         + H  R +  +E   A +E  + 
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRD-------SKAHRSRTKSSKEPPSAYKEPPKA 299

Query: 141 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 200
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359

Query: 201 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 245
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419

Query: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474

Query: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 341
           E  +  E  + + +AS  S       E S    + N
Sbjct: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  248 bits (633), Expect = 2e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 63   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 120
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 121  ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 176
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 177  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 236
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538

Query: 237  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 296
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589

Query: 297  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 356
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634

Query: 357  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 406
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694

Query: 407  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754

Query: 464  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814

Query: 516  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874

Query: 575  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934

Query: 635  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993

Query: 695  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 725
            + E+ R+  P  + P   P W    E    KR
Sbjct: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 93  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 149 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 201
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308

Query: 202 AHHRTM-------RED--YSDKVKASHWSRSPPRP 227
           A+ R         R+D   S +   S  SR  P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 140 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 193
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 194 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 238
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 299 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 359 ES 360
           +S
Sbjct: 408 KS 409



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 62/336 (18%), Positives = 100/336 (29%), Gaps = 35/336 (10%)

Query: 21  KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEED 80
           +RR  ++ ++   R K       +RD    G             S  R   S E+R E  
Sbjct: 195 ERRPRRDRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVA 246

Query: 81  DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQ 140
            S +        +           RK++         + H  R +  +E   A +E  + 
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRD-------SKAHRSRTKSSKEPPSAYKEPPKA 299

Query: 141 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 200
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359

Query: 201 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 245
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419

Query: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474

Query: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 341
           E  +  E  + + +AS  S       E S    + N
Sbjct: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 359  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 405
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 406  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 464  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 516  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 575  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 635  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 695  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 727
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 728  -------SPRPPEGGLGYSQLGDDD 745
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 49/283 (17%), Positives = 107/283 (37%), Gaps = 14/283 (4%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHCMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K  +
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDR 93

Query: 90  QMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH 149
           + + + +   R D   K + H   + ++    ++    + Q+ + +    + R   + + 
Sbjct: 94  RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153

Query: 150 SRRERD-----RLEQLERKRERERKM-REQQKEQREQKE--RERRAEERRKER-EARREV 200
           S  E D     ++ +   K  R  K+ +E+ +++RE K   ++R    R++E  ++ + V
Sbjct: 154 SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTV 213

Query: 201 SAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEERDLLSDLQ 256
            +  R  R  +     +S    SP      + ++L   R       +   +     S  Q
Sbjct: 214 DSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQ 273

Query: 257 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299
            +S   ++ S+ +SS+      S  +           S+ E S
Sbjct: 274 SVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 18/70 (25%), Positives = 32/70 (45%)

Query: 249 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 308
           RDLL   Q   +  ++ SS   S  +  SGS +   EE ++  +   ++ S +E    + 
Sbjct: 120 RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 309 EEEETGSNSE 318
            +E+T    E
Sbjct: 180 HKEKTRKERE 189


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 359  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 405
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 406  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 464  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 516  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 575  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 635  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 695  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 727
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 728  -------SPRPPEGGLGYSQLGDDD 745
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 49/283 (17%), Positives = 107/283 (37%), Gaps = 14/283 (4%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHCMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K  +
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDR 93

Query: 90  QMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH 149
           + + + +   R D   K + H   + ++    ++    + Q+ + +    + R   + + 
Sbjct: 94  RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153

Query: 150 SRRERD-----RLEQLERKRERERKM-REQQKEQREQKE--RERRAEERRKER-EARREV 200
           S  E D     ++ +   K  R  K+ +E+ +++RE K   ++R    R++E  ++ + V
Sbjct: 154 SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTV 213

Query: 201 SAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEERDLLSDLQ 256
            +  R  R  +     +S    SP      + ++L   R       +   +     S  Q
Sbjct: 214 DSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQ 273

Query: 257 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299
            +S   ++ S+ +SS+      S  +           S+ E S
Sbjct: 274 SVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 18/70 (25%), Positives = 32/70 (45%)

Query: 249 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 308
           RDLL   Q   +  ++ SS   S  +  SGS +   EE ++  +   ++ S +E    + 
Sbjct: 120 RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 309 EEEETGSNSE 318
            +E+T    E
Sbjct: 180 HKEKTRKERE 189


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 407 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 466
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243

Query: 467 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 525
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 526 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 585
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 586 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 645
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 646 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  240 bits (613), Expect = 3e-63
 Identities = 130/336 (38%), Positives = 198/336 (58%), Gaps = 16/336 (4%)

Query: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 468
           + ++ L+ + EG +  VY+A+DK T++IVA+K++K+    + K+G   T+LREI  + + 
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 469 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 528
            HPNI+ + +     +   I +V +++E DL+ +++       P  +K  M+  L+G+++
Sbjct: 70  SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 529 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGA 588
           LH +WILHRDLK +NLLL   G+LK+ DFGLA+ +GSP +AYT  VVT WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 589 KEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK 648
           + Y   VDMW+VGCI  ELL + P  PG S++DQ+ ++F+ LGTP+E+ WP    LP   
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245

Query: 649 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 708
            +TF   P   L   F A   D   DL+     + P  RI+A   LK +YF   P P   
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304

Query: 709 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 736
                P  P ++ +++      +KR  +    +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  240 bits (612), Expect = 4e-63
 Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           +++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI  + + +H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
            NIV + +++      K+ +V  + + DLK   ++      P  VK+ + QLL+G+   H
Sbjct: 61  KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118

Query: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 590
              +LHRDLK  NLL++  G LK+ DFGLAR +G P++ Y+  VVTLWYR P++L GAK 
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 591 YSTAVDMWSVGCIFGELLTQ-KPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
           YST++DMWS GCIF EL    +PLFPG    DQ+ ++F+ LGTP+E+ WP  ++LP  K 
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 701
             +  +P           L+  G DL+   L   P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 333
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100

Query: 334 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 392
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147

Query: 393 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 450
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207

Query: 451 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 510
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264

Query: 511 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 570
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324

Query: 571 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 630
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384

Query: 631 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 690
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443

Query: 691 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 728
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 333
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 35  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94

Query: 334 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 392
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 95  SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141

Query: 393 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 450
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201

Query: 451 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 510
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258

Query: 511 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 570
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318

Query: 571 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 630
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378

Query: 631 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 690
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437

Query: 691 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 728
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  234 bits (598), Expect = 2e-61
 Identities = 127/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)

Query: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
           ++++  L RI EG +G+V++AK  +T EIVALK++ + + ++GFP  +LREI   L+   
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59

Query: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
            N   V+   V  +     +   ++  DL  ++   ++P    +VK+ +  LL+GV   H
Sbjct: 60  DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAK 589
            N I+HRDLK +NLL+S +G LK+ DFGLAR +     + YT  V T WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649
           +Y   VD+WSVGCI GELL   PLFPGK++I+Q+  V + LGTP+ ++WP  +ELP   K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 709
           ++F E     L +     +S Q  DL+ +FL Y P +RI+A   L H+YF   PLP  PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298

Query: 710 MFP 712
             P
Sbjct: 299 ELP 301


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  230 bits (587), Expect = 3e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 471
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 472 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 531
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231

Query: 532 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 591
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291

Query: 592 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 650
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351

Query: 651 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 703
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 1e-59
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 408 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 466
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 467 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 519
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 520 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 579
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 580 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 639
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 640 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 699
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 700 RE 701
           ++
Sbjct: 301 QD 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.129    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,580,051
Number of Sequences: 37866
Number of extensions: 1959448
Number of successful extensions: 141535
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2661
Number of HSP's successfully gapped in prelim test: 1556
Number of HSP's that attempted gapping in prelim test: 18590
Number of HSP's gapped (non-prelim): 35028
length of query: 771
length of database: 18,247,518
effective HSP length: 110
effective length of query: 661
effective length of database: 14,082,258
effective search space: 9308372538
effective search space used: 9308372538
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.