Search of human proteins with 16332360

Search of human proteins with 16332360

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins)
isoform 3 [Homo sapiens]
         (526 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]   1042   0.0  
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]   1042   0.0  
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      362   e-100
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      303   3e-82
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      290   2e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      288   6e-78
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   271   8e-73
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        270   2e-72
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             254   1e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           252   5e-67
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   246   5e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   246   5e-65
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    242   5e-64
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    242   5e-64
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   241   2e-63
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   240   2e-63
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   240   3e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        239   3e-63
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          239   3e-63
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        234   1e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    230   2e-60
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 229   6e-60
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]                   229   6e-60
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]                   228   1e-59

>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 365

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 366 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 425

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 426 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 485

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 486 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 545

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 546 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 605

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 606 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 665

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 666 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 725

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 726 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 24/192 (12%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE-----------EGS 49
           M  ++ +   +D    E+K +  +    E        EE+++   E           E S
Sbjct: 91  MSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 150

Query: 50  TSE-----------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 98
             E           E E +  E+++E+ E       A E+  E  +  E+S       E+
Sbjct: 151 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 210

Query: 99  HLLVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKY 156
           +   V  S + R          E+G+G    +   + E D + D   +S  E K    + 
Sbjct: 211 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 270

Query: 157 LPALQGCRSVEE 168
             A  G  S EE
Sbjct: 271 SSAESGSGSEEE 282



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 28/122 (22%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 5   DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59
           D + D  +  DS       + S  E     ++E+ +E++     E+E      +   EE+
Sbjct: 71  DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 130

Query: 60  EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 119
           ++   E E     E A E S     E +  E  ER+ E    +  + +  R+  E E   
Sbjct: 131 DKARREWERQKRREMAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRA 187

Query: 120 EE 121
           EE
Sbjct: 188 EE 189



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 24/127 (18%), Positives = 51/127 (40%), Gaps = 8/127 (6%)

Query: 2   EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE---- 57
           E RD   ++   +   R+  S E    E  S + +  ++   +E+     +E  +E    
Sbjct: 52  ELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHA 111

Query: 58  ---EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 114
              E+E E E  +     ++ + +  E     EM+ +  R   + L  +   R +R+   
Sbjct: 112 RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR-ERERKM 170

Query: 115 SEEAEEE 121
            E+ +E+
Sbjct: 171 REQQKEQ 177


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 255 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 314

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 315 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 375 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 434

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 435 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 494

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 495 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 554

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 555 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 614

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 615 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 674

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 675 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 734

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 735 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 780



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 34/146 (23%), Positives = 49/146 (33%), Gaps = 19/146 (13%)

Query: 4   RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 63
           RD L  L+   + ERK    +    E        EE  +E E     S       E+  +
Sbjct: 163 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 222

Query: 64  ----------------EEEETGSNSEEASEQSAEE---VSEEEMSEDEERENENHLLVVP 104
                           E  E G   +   E+  EE   +S+ +   D ER+  +      
Sbjct: 223 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 282

Query: 105 ESRFDRDSGESEEAEEEVGEGTPQSS 130
           ES    +  E EE EEE    T + S
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEES 308



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 28/128 (21%), Positives = 49/128 (38%), Gaps = 11/128 (8%)

Query: 5   DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59
           D + D  +  DS       + S  E     ++E+ +E++     E+E      +   EE+
Sbjct: 71  DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 130

Query: 60  EEEEEEEETGSNSEEASEQSAEEVSEE------EMSEDEERENENHLLVVPESRFDRDSG 113
           ++   E E     E A E S  E   +      +  E  ER+ E    +  + +  R+  
Sbjct: 131 DKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQK 190

Query: 114 ESEEAEEE 121
           E E   EE
Sbjct: 191 ERERRAEE 198


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 223 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 282

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 283 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 342

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 343 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 402

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 403 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 462

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 463 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 522

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 523 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 582

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 583 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 642

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 643 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 702

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 703 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 748



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 10/108 (9%)

Query: 15  DSERKTSSAESS-SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 73
           D +RK      S SAE G  +  +E+E E E  +         EE+++   E E     E
Sbjct: 68  DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRK------RHREEQDKARREWERQKRRE 121

Query: 74  EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 121
            A E S     E +  E  ER+ E    +  + +  R+  E E   EE
Sbjct: 122 MAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 166


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 212 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 271

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 272 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 331

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 332 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 391

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 392 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 451

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 452 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 511

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 512 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 571

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 572 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 631

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 632 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 691

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 692 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 737



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 24/192 (12%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE-----------EGS 49
           M  ++ +   +D    E+K +  +    E        EE+++   E           E S
Sbjct: 57  MSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 116

Query: 50  TSE-----------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 98
             E           E E +  E+++E+ E       A E+  E  +  E+S       E+
Sbjct: 117 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 176

Query: 99  HLLVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKY 156
           +   V  S + R          E+G+G    +   + E D + D   +S  E K    + 
Sbjct: 177 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 236

Query: 157 LPALQGCRSVEE 168
             A  G  S EE
Sbjct: 237 SSAESGSGSEEE 248



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 28/122 (22%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 5   DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59
           D + D  +  DS       + S  E     ++E+ +E++     E+E      +   EE+
Sbjct: 37  DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 96

Query: 60  EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 119
           ++   E E     E A E S     E +  E  ER+ E    +  + +  R+  E E   
Sbjct: 97  DKARREWERQKRREMAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRA 153

Query: 120 EE 121
           EE
Sbjct: 154 EE 155



 Score = 29.3 bits (64), Expect = 9.2
 Identities = 24/127 (18%), Positives = 51/127 (40%), Gaps = 8/127 (6%)

Query: 2   EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE---- 57
           E RD   ++   +   R+  S E    E  S + +  ++   +E+     +E  +E    
Sbjct: 18  ELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHA 77

Query: 58  ---EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 114
              E+E E E  +     ++ + +  E     EM+ +  R   + L  +   R +R+   
Sbjct: 78  RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR-ERERKM 136

Query: 115 SEEAEEE 121
            E+ +E+
Sbjct: 137 REQQKEQ 143


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 376

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 377 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 436

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 437 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 496

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 497 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 556

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 557 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 616

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 617 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 676

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 677 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 736

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 737 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 782



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 10/108 (9%)

Query: 15  DSERKTSSAESS-SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 73
           D +RK      S SAE G  +  +E+E E E  +         EE+++   E E     E
Sbjct: 102 DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRK------RHREEQDKARREWERQKRRE 155

Query: 74  EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 121
            A E S     E +  E  ER+ E    +  + +  R+  E E   EE
Sbjct: 156 MAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 200


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 1042 bits (2694), Expect = 0.0
 Identities = 521/526 (99%), Positives = 522/526 (99%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 245 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 304

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 305 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 364

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 365 EVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 424

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 425 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 484

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 485 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 544

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 545 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFG 604

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFG
Sbjct: 605 ELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFG 664

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 665 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 724

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 725 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1042 bits (2694), Expect = 0.0
 Identities = 521/526 (99%), Positives = 522/526 (99%)

Query: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 255 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 314

Query: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 315 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374

Query: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
           EVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 375 EVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 434

Query: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 435 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 494

Query: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 495 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 554

Query: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 555 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFG 614

Query: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
           ELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFG
Sbjct: 615 ELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFG 674

Query: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 675 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 734

Query: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 735 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 780



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 41/190 (21%), Positives = 65/190 (34%), Gaps = 36/190 (18%)

Query: 15  DSERKTSSAESS-SAESGSGS-----EEEEEEEEEEEEEGSTSE---------------- 52
           D +RK      S SAE G  +     E E  +   EE++ +  E                
Sbjct: 102 DEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 161

Query: 53  ------------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 100
                       E E +  E+++E+ E       A E+  E  +  E+S       E++ 
Sbjct: 162 ERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 221

Query: 101 LVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKYLP 158
             V  S + R          E+G+G    +   + E D + D   +S  E K    +   
Sbjct: 222 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 281

Query: 159 ALQGCRSVEE 168
           A  G  S EE
Sbjct: 282 AESGSGSEEE 291


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  362 bits (928), Expect = e-100
 Identities = 176/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)

Query: 163 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 222
           CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI  +L+
Sbjct: 33  CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92

Query: 223 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 282
            +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M  PF   +VK +++Q+LRG++
Sbjct: 93  LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152

Query: 283 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLG 342
           +LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P+K  TP VVTLWYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212

Query: 343 AKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAV 402
               +T++DMW+VGCI  ELL  +PL PG SEI QI+ + + LGTPSE IWPG+S+LP V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272

Query: 403 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 462
            + +  + PYNNL+ +F   LS+ G  L++    Y P +R +A D L+  YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331

Query: 463 PSMFPTWPAKSEQQRVKRGTSPRPPEG 489
           P + PT+P      R KR  +P   EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  303 bits (776), Expect = 3e-82
 Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)

Query: 202 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 261
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 262 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 321
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 322 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 381
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 382 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 441
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 442 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 489
           R +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  290 bits (743), Expect = 2e-78
 Identities = 145/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)

Query: 202 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 261
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 262 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 321
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 322 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 381
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 382 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 441
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++         
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233

Query: 442 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 489
             +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  288 bits (738), Expect = 6e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 202 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 261
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 262 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 321
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 322 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 381
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 382 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 441
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 442 RISAEDGLKHEYFRETPL 459
           R +A D L+  YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  271 bits (694), Expect = 8e-73
 Identities = 136/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           ++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 284
           PNIV + ++V   N  K+Y+V  ++  DLK  M++     LP   +K+ + QLL+GV   
Sbjct: 61  PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118

Query: 285 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 344
           H + ++HRDLK  NLL++  G +K+ DFGLAR +G PL+ YT  VVTLWYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404
            Y+TAVD+WS+GCIF E++T+K LFPG SEIDQ+ ++F+ LGTPSE  WPG ++LP  K 
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238

Query: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 454
            +F +     L +     L  +G DL+ + L Y P +RI+A+  L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  270 bits (691), Expect = 2e-72
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 284
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118

Query: 285 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 344
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178

Query: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238

Query: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 461
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  254 bits (649), Expect = 1e-67
 Identities = 124/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 279
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 280 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 339
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT  VVTLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174

Query: 340 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 399
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 400 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 456
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  252 bits (644), Expect = 5e-67
 Identities = 122/297 (41%), Positives = 196/297 (65%), Gaps = 14/297 (4%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 279
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 280 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 339
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT   +TLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174

Query: 340 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 399
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 400 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 456
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  246 bits (627), Expect = 5e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 114  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 160
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 161  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 218
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 219  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 270
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 271  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 329
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 330  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 389
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 390  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 449
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 450  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 482
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 483  -------SPRPPEGGLGYSQLGDDD 500
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 18/70 (25%), Positives = 32/70 (45%)

Query: 4   RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 63
           RDLL   Q   +  ++ SS   S  +  SGS +   EE ++  +   ++ S +E    + 
Sbjct: 120 RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 64  EEEETGSNSE 73
            +E+T    E
Sbjct: 180 HKEKTRKERE 189


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  246 bits (627), Expect = 5e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 114  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 160
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 161  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 218
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 219  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 270
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 271  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 329
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 330  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 389
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 390  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 449
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 450  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 482
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 483  -------SPRPPEGGLGYSQLGDDD 500
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 18/70 (25%), Positives = 32/70 (45%)

Query: 4   RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 63
           RDLL   Q   +  ++ SS   S  +  SGS +   EE ++  +   ++ S +E    + 
Sbjct: 120 RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 64  EEEETGSNSE 73
            +E+T    E
Sbjct: 180 HKEKTRKERE 189


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  242 bits (618), Expect = 5e-64
 Identities = 131/329 (39%), Positives = 191/329 (58%), Gaps = 11/329 (3%)

Query: 162  GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
            G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI  + 
Sbjct: 698  GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILR 757

Query: 222  KAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTL 273
            +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +K+ 
Sbjct: 758  QLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSF 817

Query: 274  MIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTL 332
            M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V+TL
Sbjct: 818  MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 877

Query: 333  WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392
            WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P   +
Sbjct: 878  WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937

Query: 393  WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 452
            WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L+ E
Sbjct: 938  WPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQALQCE 996

Query: 453  YFRET-PLPIDPSMFPTWPAKSEQQRVKR 480
            + R+  P  + P   P W    E    KR
Sbjct: 997  FLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  242 bits (618), Expect = 5e-64
 Identities = 131/329 (39%), Positives = 191/329 (58%), Gaps = 11/329 (3%)

Query: 162  GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
            G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI  + 
Sbjct: 698  GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILR 757

Query: 222  KAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTL 273
            +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +K+ 
Sbjct: 758  QLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSF 817

Query: 274  MIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTL 332
            M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V+TL
Sbjct: 818  MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 877

Query: 333  WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392
            WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P   +
Sbjct: 878  WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937

Query: 393  WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 452
            WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L+ E
Sbjct: 938  WPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQALQCE 996

Query: 453  YFRET-PLPIDPSMFPTWPAKSEQQRVKR 480
            + R+  P  + P   P W    E    KR
Sbjct: 997  FLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243

Query: 222 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 280
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 281 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 340
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 341 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 400
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 401 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  240 bits (613), Expect = 2e-63
 Identities = 130/336 (38%), Positives = 198/336 (58%), Gaps = 16/336 (4%)

Query: 167 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 223
           + ++ L+ + EG +  VY+A+DK T++IVA+K++K+    + K+G   T+LREI  + + 
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 224 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 283
            HPNI+ + +     +   I +V +++E DL+ +++       P  +K  M+  L+G+++
Sbjct: 70  SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 284 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGA 343
           LH +WILHRDLK +NLLL   G+LK+ DFGLA+ +GSP +AYT  VVT WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 344 KEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK 403
           + Y   VDMW+VGCI  ELL + P  PG S++DQ+ ++F+ LGTP+E+ WP    LP   
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245

Query: 404 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 463
            +TF   P   L   F A   D   DL+     + P  RI+A   LK +YF   P P   
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304

Query: 464 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 491
                P  P ++ +++      +KR  +    +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  240 bits (612), Expect = 3e-63
 Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           +++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI  + + +H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285
            NIV + +++      K+ +V  + + DLK   ++      P  VK+ + QLL+G+   H
Sbjct: 61  KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118

Query: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 345
              +LHRDLK  NLL++  G LK+ DFGLAR +G P++ Y+  VVTLWYR P++L GAK 
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 346 YSTAVDMWSVGCIFGELLTQ-KPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404
           YST++DMWS GCIF EL    +PLFPG    DQ+ ++F+ LGTP+E+ WP  ++LP  K 
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237

Query: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 456
             +  +P           L+  G DL+   L   P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 29  ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 88
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100

Query: 89  SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147

Query: 148 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 205
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207

Query: 206 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 265
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264

Query: 266 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 325
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324

Query: 326 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 385
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384

Query: 386 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 445
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443

Query: 446 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 483
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 29  ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 88
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 35  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94

Query: 89  SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 95  SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141

Query: 148 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 205
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201

Query: 206 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 265
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258

Query: 266 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 325
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318

Query: 326 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 385
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378

Query: 386 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 445
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437

Query: 446 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 483
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  234 bits (598), Expect = 1e-61
 Identities = 127/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)

Query: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
           ++++  L RI EG +G+V++AK  +T EIVALK++ + + ++GFP  +LREI   L+   
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59

Query: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285
            N   V+   V  +     +   ++  DL  ++   ++P    +VK+ +  LL+GV   H
Sbjct: 60  DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAK 344
            N I+HRDLK +NLL+S +G LK+ DFGLAR +     + YT  V T WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404
           +Y   VD+WSVGCI GELL   PLFPGK++I+Q+  V + LGTP+ ++WP  +ELP   K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 464
           ++F E     L +     +S Q  DL+ +FL Y P +RI+A   L H+YF   PLP  PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298

Query: 465 MFP 467
             P
Sbjct: 299 ELP 301


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 167 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 226
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 227 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 286
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231

Query: 287 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 346
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291

Query: 347 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 405
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351

Query: 406 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 458
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 6e-60
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 163 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 221
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 222 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 274
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 275 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 334
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 335 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 394
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 395 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 454
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 455 RE 456
           ++
Sbjct: 301 QD 302


>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 6e-60
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 163 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 221
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 222 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 274
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 275 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 334
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 335 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 394
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 395 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 454
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 455 RE 456
           ++
Sbjct: 301 QD 302


>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
          Length = 372

 Score =  228 bits (580), Expect = 1e-59
 Identities = 117/311 (37%), Positives = 182/311 (58%), Gaps = 11/311 (3%)

Query: 163 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 222
           C  V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI  +  
Sbjct: 13  CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72

Query: 223 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 276
            +H N+V + EI              IY+V ++ EHDL  L+  +   F   E+K +M  
Sbjct: 73  LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132

Query: 277 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTL 332
           LL G+ ++H N ILHRD+K +N+L++  G+LK+ DFGLAR +     S    YT  VVTL
Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192

Query: 333 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392
           WYR PELLLG ++Y   +D+W  GCI  E+ T+ P+  G +E  Q+  + +  G+ + ++
Sbjct: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252

Query: 393 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 451
           WP        +K+   +     ++ R  A + D    DL++K L   P +RI ++D L H
Sbjct: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312

Query: 452 EYFRETPLPID 462
           ++F   P+P D
Sbjct: 313 DFFWSDPMPSD 323


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.130    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,538,029
Number of Sequences: 37866
Number of extensions: 1293648
Number of successful extensions: 93672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2358
Number of HSP's successfully gapped in prelim test: 929
Number of HSP's that attempted gapping in prelim test: 15068
Number of HSP's gapped (non-prelim): 28754
length of query: 526
length of database: 18,247,518
effective HSP length: 107
effective length of query: 419
effective length of database: 14,195,856
effective search space: 5948063664
effective search space used: 5948063664
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.