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Search of human proteins with 162329612
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
(825 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 1652 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 1558 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 1556 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 1253 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 938 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 938 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 938 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 931 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 928 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 853 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 850 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 833 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 800 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 237 3e-62
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 237 3e-62
gi|4826894 phosphodiesterase 1C [Homo sapiens] 234 2e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens] 231 2e-60
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 9e-56
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 214 3e-55
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 214 3e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 211 2e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 211 2e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 211 2e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 211 2e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 211 2e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 6e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 178 2e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 1652 bits (4277), Expect = 0.0
Identities = 825/825 (100%), Positives = 825/825 (100%)
Query: 1 MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRS 60
MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRS
Sbjct: 1 MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRS 60
Query: 61 PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF 120
PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF
Sbjct: 61 PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF 120
Query: 121 AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC 180
AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC
Sbjct: 121 AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC 180
Query: 181 LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP 240
LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP
Sbjct: 181 LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP 240
Query: 241 SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ 300
SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ
Sbjct: 241 SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ 300
Query: 301 EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360
EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT
Sbjct: 301 EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360
Query: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420
LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS
Sbjct: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420
Query: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480
NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV
Sbjct: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480
Query: 481 LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL 540
LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL
Sbjct: 481 LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL 540
Query: 541 YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV 600
YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV
Sbjct: 541 YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV 600
Query: 601 HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI 660
HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI
Sbjct: 601 HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI 660
Query: 661 SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ 720
SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ
Sbjct: 661 SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ 720
Query: 721 QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPS 780
QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPS
Sbjct: 721 QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPS 780
Query: 781 TAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 825
TAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 781 TAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 825
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 1558 bits (4033), Expect = 0.0
Identities = 781/784 (99%), Positives = 781/784 (99%)
Query: 42 GRSVSFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 101
G S FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS
Sbjct: 103 GSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 162
Query: 102 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL 161
RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL
Sbjct: 163 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL 222
Query: 162 SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ 221
SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ
Sbjct: 223 SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ 282
Query: 222 VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM 281
VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM
Sbjct: 283 VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM 342
Query: 282 HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER 341
HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER
Sbjct: 343 HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER 402
Query: 342 DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE 401
DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE
Sbjct: 403 DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE 462
Query: 402 ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF 461
ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF
Sbjct: 463 ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF 522
Query: 462 QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 521
QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV
Sbjct: 523 QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 582
Query: 522 LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ 581
LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ
Sbjct: 583 LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ 642
Query: 582 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP 641
VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP
Sbjct: 643 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP 702
Query: 642 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE 701
LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE
Sbjct: 703 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE 762
Query: 702 VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP 761
VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP
Sbjct: 763 VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP 822
Query: 762 AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG 821
AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG
Sbjct: 823 AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG 882
Query: 822 GDPT 825
GDPT
Sbjct: 883 GDPT 886
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 1556 bits (4029), Expect = 0.0
Identities = 793/832 (95%), Positives = 795/832 (95%), Gaps = 18/832 (2%)
Query: 6 APRARPRPPALALPPTGPESLTHFPFSDEDTRRH--------PPGRSV----SFEAENGP 53
APRA RP + PP+ P F RR GR FEAENGP
Sbjct: 35 APRAPRRPRS---PPSSP---VFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGP 88
Query: 54 TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE 113
TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE
Sbjct: 89 TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE 148
Query: 114 DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET 173
DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET
Sbjct: 149 DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET 208
Query: 174 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 233
LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK
Sbjct: 209 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 268
Query: 234 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 293
QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR
Sbjct: 269 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 328
Query: 294 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 353
FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT
Sbjct: 329 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 388
Query: 354 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 413
MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD
Sbjct: 389 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 448
Query: 414 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 473
VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR
Sbjct: 449 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 508
Query: 474 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 533
KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN
Sbjct: 509 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 568
Query: 534 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 593
PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW
Sbjct: 569 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 628
Query: 594 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE 653
ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE
Sbjct: 629 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE 688
Query: 654 EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL 713
EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL
Sbjct: 689 EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL 748
Query: 714 EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP 773
EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP
Sbjct: 749 EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP 808
Query: 774 GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 825
GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 809 GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 860
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 200 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 259
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
Query: 260 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 319
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
Query: 320 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 379
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
Query: 380 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 439
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
Query: 440 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 499
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
Query: 500 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 559
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
Query: 560 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 619
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
Query: 620 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 679
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
Query: 680 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 739
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
Query: 740 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 799
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
Query: 800 ACAGTFGEDTSALPAPGGGGSGGDPT 825
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 47 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 103
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 95 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 152
Query: 104 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 163
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 153 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 212
Query: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 317
Query: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 318 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 377
Query: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 378 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 437
Query: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 438 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 497
Query: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 498 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 557
Query: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 558 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 617
Query: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 618 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 675
Query: 644 DKFQFELTLEEEEEE 658
+KFQFELTL+EE+ E
Sbjct: 676 EKFQFELTLDEEDSE 690
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 47 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 103
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 80 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 137
Query: 104 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 163
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 138 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 197
Query: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
Query: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 302
Query: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 303 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 362
Query: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 363 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 422
Query: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 423 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 482
Query: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 483 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 542
Query: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 543 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 602
Query: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 603 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 660
Query: 644 DKFQFELTLEEEEEE 658
+KFQFELTL+EE+ E
Sbjct: 661 EKFQFELTLDEEDSE 675
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 47 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 103
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 95 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 152
Query: 104 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 163
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 153 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 212
Query: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 317
Query: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 318 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 377
Query: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 378 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 437
Query: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 438 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 497
Query: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 498 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 557
Query: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 558 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 617
Query: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 618 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 675
Query: 644 DKFQFELTLEEEEEE 658
+KFQFELTL+EE+ E
Sbjct: 676 EKFQFELTLDEEDSE 690
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 931 bits (2405), Expect = 0.0
Identities = 484/684 (70%), Positives = 562/684 (82%), Gaps = 41/684 (5%)
Query: 26 LTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRE 83
+ +FPF RRH + F+ +NG S GRSPLD SPG L+L A SQRRE
Sbjct: 4 VNNFPF-----RRHS---WICFDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRE 53
Query: 84 SFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-- 141
SFLYRSDSDYD+SPK+MSRNSS+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+
Sbjct: 54 SFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDR 113
Query: 142 VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKF 201
PS KRSP+ + KAT++EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KF
Sbjct: 114 APS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKF 172
Query: 202 KRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPP 261
KRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 173 KRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK---------- 222
Query: 262 PPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV 321
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +
Sbjct: 223 -------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRI 275
Query: 322 SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVL 381
++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+
Sbjct: 276 AELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVV 335
Query: 382 QSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVL 441
QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVL
Sbjct: 336 QSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVL 395
Query: 442 ENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET 501
ENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVET
Sbjct: 396 ENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVET 455
Query: 502 KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE 561
KKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERE
Sbjct: 456 KKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERE 515
Query: 562 RGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSA 621
RGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S
Sbjct: 516 RGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQST 575
Query: 622 IRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQEALT 674
I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ + L
Sbjct: 576 IPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLC 633
Query: 675 AQGLSGVEEALDATIAWEASPAQE 698
Q E LD + EA +E
Sbjct: 634 TQDSESTEIPLDEQVEEEAVGEEE 657
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 47 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 104
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 153 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 210
Query: 105 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 162
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 211 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 269
Query: 163 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 222
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 270 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 329
Query: 223 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 282
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 330 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 372
Query: 283 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 342
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 373 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 432
Query: 343 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 402
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 433 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 492
Query: 403 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 462
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 493 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 552
Query: 463 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 522
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 553 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612
Query: 523 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 582
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 613 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 672
Query: 583 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 642
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 673 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 730
Query: 643 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 695
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 731 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 790
Query: 696 AQE 698
+E
Sbjct: 791 EEE 793
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 853 bits (2205), Expect = 0.0
Identities = 457/682 (67%), Positives = 526/682 (77%), Gaps = 37/682 (5%)
Query: 1 MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTR---RHPPGRSVSFEAENGPTPSP 57
M+ AP P P + P G L ++ R R + F+ ENG S
Sbjct: 1 MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGL--SC 58
Query: 58 GRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDL 115
GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+
Sbjct: 59 GRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDM 118
Query: 116 IVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETL 174
IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+LA ETL
Sbjct: 119 IVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETL 178
Query: 175 EELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQ 234
+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q
Sbjct: 179 DELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQ 238
Query: 235 NEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRF 294
EVE+P T +E AP QPMS+I+GL L HS SL+++ +PRF
Sbjct: 239 TEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSSATVPRF 278
Query: 295 GVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTM 354
GV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+
Sbjct: 279 GVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTL 338
Query: 355 VTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDV 414
TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDV
Sbjct: 339 ATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDV 398
Query: 415 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRK 474
DHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+
Sbjct: 399 DHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRR 458
Query: 475 MVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNP 534
MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNP
Sbjct: 459 MVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNP 518
Query: 535 TKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 594
TKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWE
Sbjct: 519 TKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
Query: 595 TWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL-- 652
TWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQFELTL
Sbjct: 579 TWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEE 632
Query: 653 -EEEEEEEISMAQIPCTAQEAL 673
EEE+EEE + A+EAL
Sbjct: 633 AEEEDEEEEEEGEETALAKEAL 654
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 850 bits (2197), Expect = 0.0
Identities = 447/633 (70%), Positives = 511/633 (80%), Gaps = 34/633 (5%)
Query: 47 FEAENGPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 104
F+ ENG S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNS
Sbjct: 82 FDLENGL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 139
Query: 105 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSE 163
SV S+ H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E
Sbjct: 140 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 199
Query: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
+T Q+LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVS
Sbjct: 200 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 259
Query: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
EYIS TFLD+Q EVE+P T +E AP QPMS+I+GL L HS
Sbjct: 260 EYISRTFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHS 299
Query: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDL
Sbjct: 300 ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL 359
Query: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
LK F+IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEIL
Sbjct: 360 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 419
Query: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
AALFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQN
Sbjct: 420 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 479
Query: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
LS +QR SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+
Sbjct: 480 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ 539
Query: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVG
Sbjct: 540 NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG 599
Query: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
FIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G P
Sbjct: 600 FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------P 653
Query: 644 DKFQFELTL---EEEEEEEISMAQIPCTAQEAL 673
D+FQFELTL EEE+EEE + A+EAL
Sbjct: 654 DRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 72 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 131
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 132 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 190
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 191 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 250
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
Query: 251 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 310
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
Query: 311 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 370
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
Query: 371 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 430
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
Query: 431 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 490
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
Query: 491 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 550
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
Query: 551 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 610
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
Query: 611 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 667
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
Query: 668 TAQEAL 673
A+EAL
Sbjct: 575 LAKEAL 580
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 155 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 214
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
Query: 215 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 274
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
Query: 275 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 334
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
Query: 335 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 394
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Query: 395 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 454
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
Query: 455 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 514
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
Query: 515 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 574
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Query: 575 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 634
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
Query: 635 RGPGHPPLPDKFQFELTLEEEEEE 658
R L +KFQFELTL+EE+ E
Sbjct: 497 R--DCQGLMEKFQFELTLDEEDSE 518
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 598
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 598
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 234 bits (598), Expect = 2e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 306 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 365
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
Query: 366 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 424
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
Query: 425 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 483
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
Query: 484 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 543
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
Query: 544 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 603
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
Query: 604 AQEILD 609
++D
Sbjct: 450 VSPLID 455
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 231 bits (590), Expect = 2e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 606
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 607 ILDTLEDNR 615
+ D ED++
Sbjct: 447 LAD--EDSK 453
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (549), Expect = 9e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 271 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 327
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 328 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 387
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 388 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 447
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 448 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 507
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 508 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 567
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 568 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 625
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
Query: 626 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 658
P + SRG PD E EE+E
Sbjct: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 304 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 363
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 364 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 423
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 424 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 482
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 483 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 531
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 532 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 590
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 591 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 631
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 783
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 304 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 363
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 364 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 423
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 424 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 482
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 483 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 531
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 532 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 590
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 591 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 631
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
Query: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
Query: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
Query: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
Query: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
Query: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
+ +++ W H A ++ L DN
Sbjct: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 522 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 581
Query: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 582 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 641
Query: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 642 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 701
Query: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 702 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 759
Query: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 760 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 819
Query: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
+ +++ W H A ++ L DN
Sbjct: 820 FITDMFDAWDAFAHLPA--LMQHLADN 844
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 487 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 546
Query: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 547 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 606
Query: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 607 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 666
Query: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 667 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 724
Query: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 725 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
+ +++ W H A ++ L DN
Sbjct: 785 FITDMFDAWDAFAHLPA--LMQHLADN 809
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 445 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 504
Query: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 505 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 564
Query: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 565 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 624
Query: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 625 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 682
Query: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 683 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 742
Query: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
+ +++ W H A ++ L DN
Sbjct: 743 FITDMFDAWDAFAHLPA--LMQHLADN 767
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 542 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 601
Query: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 602 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 661
Query: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 662 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 721
Query: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 722 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 779
Query: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 780 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 839
Query: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
+ +++ W H A ++ L DN
Sbjct: 840 FITDMFDAWDAFAHLPA--LMQHLADN 864
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (533), Expect = 6e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 368 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 427
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
Query: 428 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 487
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
Query: 488 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 547
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
Query: 548 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 597
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 3e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 368 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 427
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
Query: 428 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 487
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
Query: 488 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 547
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
Query: 548 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 588
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 178 bits (451), Expect = 2e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 308 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 364
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 365 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 392
Y D+ YHN +HA DVL + L P
Sbjct: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Query: 393 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 440
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
Query: 441 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 499
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
Query: 500 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 559
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
Query: 560 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 596
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 292 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 350
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 351 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 410
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 411 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 470
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 471 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 530
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 531 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 590
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 591 PLWETWADLVHPDAQEILDTLEDNRDWY 618
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 292 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 350
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 351 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 410
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 411 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 470
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 471 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 530
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 531 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 590
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 591 PLWETWADLVHPDAQEILDTLEDNRDWY 618
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,902,972
Number of Sequences: 37866
Number of extensions: 1920142
Number of successful extensions: 16106
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 243
Number of HSP's that attempted gapping in prelim test: 13831
Number of HSP's gapped (non-prelim): 2110
length of query: 825
length of database: 18,247,518
effective HSP length: 111
effective length of query: 714
effective length of database: 14,044,392
effective search space: 10027695888
effective search space used: 10027695888
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.