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Search of human proteins with 162329610
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
(860 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 1718 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 1556 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 1556 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 1253 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 955 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 939 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 939 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 928 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 928 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 855 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 854 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 833 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 800 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 237 3e-62
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 237 3e-62
gi|4826894 phosphodiesterase 1C [Homo sapiens] 234 2e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens] 231 2e-60
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 9e-56
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 214 3e-55
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 214 3e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 211 2e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 211 2e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 211 2e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 211 2e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 211 2e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 7e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 178 2e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 1718 bits (4449), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MARPRGLGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFR 60
MARPRGLGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFR
Sbjct: 1 MARPRGLGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFR 60
Query: 61 RRLRLLRSCQDLGRQAWAGAGFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF 120
RRLRLLRSCQDLGRQAWAGAGFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF
Sbjct: 61 RRLRLLRSCQDLGRQAWAGAGFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF 120
Query: 121 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN 180
LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN
Sbjct: 121 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN 180
Query: 181 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML 240
KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML
Sbjct: 181 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML 240
Query: 241 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV 300
NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV
Sbjct: 241 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV 300
Query: 301 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA 360
PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA
Sbjct: 301 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA 360
Query: 361 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH 420
GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH
Sbjct: 361 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH 420
Query: 421 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 480
VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
Sbjct: 421 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 480
Query: 481 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT 540
LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT
Sbjct: 481 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT 540
Query: 541 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME 600
SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME
Sbjct: 541 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME 600
Query: 601 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS 660
ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS
Sbjct: 601 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS 660
Query: 661 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL 720
PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL
Sbjct: 661 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL 720
Query: 721 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV 780
DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV
Sbjct: 721 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV 780
Query: 781 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF 840
SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF
Sbjct: 781 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF 840
Query: 841 GEDTSALPAPGGGGSGGDPT 860
GEDTSALPAPGGGGSGGDPT
Sbjct: 841 GEDTSALPAPGGGGSGGDPT 860
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 1556 bits (4029), Expect = 0.0
Identities = 793/832 (95%), Positives = 795/832 (95%), Gaps = 18/832 (2%)
Query: 35 APRAPRRPRS---PPSSP---VFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGP 88
APRA RP + PP+ P F RR GR FEAENGP
Sbjct: 6 APRARPRPPALALPPTGPESLTHFPFSDEDTRRH--------PPGRSV----SFEAENGP 53
Query: 89 TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE 148
TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE
Sbjct: 54 TPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAE 113
Query: 149 DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET 208
DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET
Sbjct: 114 DLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARET 173
Query: 209 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 268
LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK
Sbjct: 174 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 233
Query: 269 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 328
QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR
Sbjct: 234 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 293
Query: 329 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 388
FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT
Sbjct: 294 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 353
Query: 389 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 448
MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD
Sbjct: 354 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 413
Query: 449 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 508
VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR
Sbjct: 414 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 473
Query: 509 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 568
KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN
Sbjct: 474 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 533
Query: 569 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 628
PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW
Sbjct: 534 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 593
Query: 629 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE 688
ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE
Sbjct: 594 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLE 653
Query: 689 EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL 748
EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL
Sbjct: 654 EEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL 713
Query: 749 EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP 808
EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP
Sbjct: 714 EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAP 773
Query: 809 GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 860
GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 774 GLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 825
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 1556 bits (4029), Expect = 0.0
Identities = 782/787 (99%), Positives = 782/787 (99%), Gaps = 4/787 (0%)
Query: 78 AGAG----FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK 133
AG G FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK
Sbjct: 100 AGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK 159
Query: 134 TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK 193
TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK
Sbjct: 160 TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK 219
Query: 194 ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS 253
ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS
Sbjct: 220 ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS 279
Query: 254 GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK 313
GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK
Sbjct: 280 GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK 339
Query: 314 KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF 373
KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF
Sbjct: 340 KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF 399
Query: 374 QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT 433
QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT
Sbjct: 400 QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT 459
Query: 434 DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC 493
DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC
Sbjct: 460 DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC 519
Query: 494 DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR 553
DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR
Sbjct: 520 DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR 579
Query: 554 IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE 613
IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE
Sbjct: 580 IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE 639
Query: 614 KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG 673
KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG
Sbjct: 640 KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG 699
Query: 674 HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE 733
HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE
Sbjct: 700 HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE 759
Query: 734 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP 793
SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP
Sbjct: 760 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP 819
Query: 794 LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG 853
LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG
Sbjct: 820 LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG 879
Query: 854 GSGGDPT 860
GSGGDPT
Sbjct: 880 GSGGDPT 886
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 235 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 294
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
Query: 295 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 354
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
Query: 355 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 414
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
Query: 415 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 474
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
Query: 475 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 534
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
Query: 535 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 594
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
Query: 595 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 654
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
Query: 655 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 714
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
Query: 715 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 774
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
Query: 775 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 834
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
Query: 835 ACAGTFGEDTSALPAPGGGGSGGDPT 860
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 955 bits (2469), Expect = 0.0
Identities = 499/662 (75%), Positives = 554/662 (83%), Gaps = 23/662 (3%)
Query: 36 PRAP-RRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGPTPSPGR 94
PR P RP SP SP SP F R+L + +S + R A F+ ENGP SPGR
Sbjct: 33 PRLPGNRPTSPKISPRSSPRNSPCFFRKLLVNKSIRQRRRFTVAHTCFDVENGP--SPGR 90
Query: 95 SPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLI 151
SPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRNSS+ SE H +DLI
Sbjct: 91 SPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLI 150
Query: 152 VTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEE 211
VTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + EE+ Q+LA ETLEE
Sbjct: 151 VTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEE 210
Query: 212 LDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNE 271
LDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+
Sbjct: 211 LDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQND 270
Query: 272 VEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGV 331
VEIPSPT K+REK++ Q M+QI+G+KKLMHS+SLNN++I RFGV
Sbjct: 271 VEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHSSSLNNTSISRFGV 315
Query: 332 KTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVT 391
T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDLLK FRI DT +T
Sbjct: 316 NTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFIT 375
Query: 392 YMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDH 451
YM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDH
Sbjct: 376 YMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDH 435
Query: 452 PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMV 511
PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMV
Sbjct: 436 PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMV 495
Query: 512 IDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTK 571
IDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK
Sbjct: 496 IDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTK 555
Query: 572 PLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 631
LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW
Sbjct: 556 SLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 615
Query: 632 ADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEE 691
ADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L +KFQFELTL+EE+
Sbjct: 616 ADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEED 673
Query: 692 EE 693
E
Sbjct: 674 SE 675
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 939 bits (2427), Expect = 0.0
Identities = 490/664 (73%), Positives = 548/664 (82%), Gaps = 30/664 (4%)
Query: 33 PLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGPTPSP 92
PL+ R R R+P + + P L + + + F+ ENGP SP
Sbjct: 54 PLSQRQSERARTPEGDGISRPTTLP--------LTTLPSIAITTVSQECFDVENGP--SP 103
Query: 93 GRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAED 149
GRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRNSS+ SE H +D
Sbjct: 104 GRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDD 163
Query: 150 LIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETL 209
LIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + EE+ Q+LA ETL
Sbjct: 164 LIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETL 223
Query: 210 EELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQ 269
EELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQ
Sbjct: 224 EELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQ 283
Query: 270 NEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRF 329
N+VEIPSPT K+REK++ Q M+QI+G+KKLMHS+SLNN++I RF
Sbjct: 284 NDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHSSSLNNTSISRF 328
Query: 330 GVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTM 389
GV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDLLK FRI DT
Sbjct: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
Query: 390 VTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDV 449
+TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDV
Sbjct: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
Query: 450 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRK 509
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRK
Sbjct: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
Query: 510 MVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNP 569
MVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNP
Sbjct: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
Query: 570 TKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 629
TK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
Query: 630 TWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEE 689
TWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L +KFQFELTL+E
Sbjct: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDE 686
Query: 690 EEEE 693
E+ E
Sbjct: 687 EDSE 690
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 939 bits (2427), Expect = 0.0
Identities = 490/664 (73%), Positives = 548/664 (82%), Gaps = 30/664 (4%)
Query: 33 PLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGPTPSP 92
PL+ R R R+P + + P L + + + F+ ENGP SP
Sbjct: 54 PLSQRQSERARTPEGDGISRPTTLP--------LTTLPSIAITTVSQECFDVENGP--SP 103
Query: 93 GRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAED 149
GRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRNSS+ SE H +D
Sbjct: 104 GRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDD 163
Query: 150 LIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETL 209
LIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + EE+ Q+LA ETL
Sbjct: 164 LIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETL 223
Query: 210 EELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQ 269
EELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQ
Sbjct: 224 EELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQ 283
Query: 270 NEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRF 329
N+VEIPSPT K+REK++ Q M+QI+G+KKLMHS+SLNN++I RF
Sbjct: 284 NDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHSSSLNNTSISRF 328
Query: 330 GVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTM 389
GV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDLLK FRI DT
Sbjct: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
Query: 390 VTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDV 449
+TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDV
Sbjct: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
Query: 450 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRK 509
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRK
Sbjct: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
Query: 510 MVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNP 569
MVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNP
Sbjct: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
Query: 570 TKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 629
TK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
Query: 630 TWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEE 689
TWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L +KFQFELTL+E
Sbjct: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDE 686
Query: 690 EEEE 693
E+ E
Sbjct: 687 EDSE 690
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 82 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 139
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 153 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 210
Query: 140 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 197
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 211 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 269
Query: 198 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 257
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 270 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 329
Query: 258 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 317
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 330 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 372
Query: 318 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 377
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 373 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 432
Query: 378 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 437
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 433 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 492
Query: 438 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 497
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 493 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 552
Query: 498 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 557
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 553 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612
Query: 558 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 617
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 613 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 672
Query: 618 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 677
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 673 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 730
Query: 678 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 730
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 731 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 790
Query: 731 AQE 733
+E
Sbjct: 791 EEE 793
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 82 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 139
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 17 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
Query: 140 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 197
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 133
Query: 198 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 257
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 134 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 193
Query: 258 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 317
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 194 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 236
Query: 318 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 377
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 237 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 296
Query: 378 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 437
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 297 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 356
Query: 438 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 497
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 357 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 416
Query: 498 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 557
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 417 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 476
Query: 558 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 617
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 477 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 536
Query: 618 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 677
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 537 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 594
Query: 678 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 730
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 595 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 654
Query: 731 AQE 733
+E
Sbjct: 655 EEE 657
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 855 bits (2208), Expect = 0.0
Identities = 460/688 (66%), Positives = 532/688 (77%), Gaps = 44/688 (6%)
Query: 37 RAPRRPRSPPSSPV-----FFASPSPTFRRRLRLLRSCQDL--GRQAWAGAG---FEAEN 86
RAP+ P P+ F++ P + R R L +L R +W + F+ EN
Sbjct: 27 RAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLEN 86
Query: 87 GPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSE 144
G S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+
Sbjct: 87 GL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASD 144
Query: 145 AHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQ 203
H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+
Sbjct: 145 LHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQK 204
Query: 204 LARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYIST 263
LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS
Sbjct: 205 LALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISR 264
Query: 264 TFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNN 323
TFLD+Q EVE+P T +E AP QPMS+I+GL L HS SL++
Sbjct: 265 TFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSS 304
Query: 324 SNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFR 383
+ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+
Sbjct: 305 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 364
Query: 384 IPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFA 443
IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA
Sbjct: 365 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 424
Query: 444 AAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQ 503
+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +Q
Sbjct: 425 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 484
Query: 504 RQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHC 563
R SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHC
Sbjct: 485 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 544
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 623
ADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI
Sbjct: 545 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
Query: 624 VHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQF 683
HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQF
Sbjct: 605 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQF 658
Query: 684 ELTL---EEEEEEEISMAQIPCTAQEAL 708
ELTL EEE+EEE + A+EAL
Sbjct: 659 ELTLEEAEEEDEEEEEEGEETALAKEAL 686
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 854 bits (2206), Expect = 0.0
Identities = 462/683 (67%), Positives = 530/683 (77%), Gaps = 39/683 (5%)
Query: 33 PLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGA-GFEAENGPTPS 91
P AP P SP SP SP R+L + +S + R A F+ ENG S
Sbjct: 4 PPAPAPVPGPGSPRGSP----RGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGL--S 57
Query: 92 PGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAED 149
GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED
Sbjct: 58 CGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGED 117
Query: 150 LIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARET 208
+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+LA ET
Sbjct: 118 MIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALET 177
Query: 209 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 268
L+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+
Sbjct: 178 LDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQ 237
Query: 269 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 328
Q EVE+P T +E AP QPMS+I+GL L HS SL+++ +PR
Sbjct: 238 QTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSSATVPR 277
Query: 329 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 388
FGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT
Sbjct: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337
Query: 389 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 448
+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHD
Sbjct: 338 LATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHD 397
Query: 449 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 508
VDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR
Sbjct: 398 VDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLR 457
Query: 509 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 568
+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSN
Sbjct: 458 RMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSN 517
Query: 569 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 628
PTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLW
Sbjct: 518 PTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLW 577
Query: 629 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL- 687
ETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQFELTL
Sbjct: 578 ETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLE 631
Query: 688 --EEEEEEEISMAQIPCTAQEAL 708
EEE+EEE + A+EAL
Sbjct: 632 EAEEEDEEEEEEGEETALAKEAL 654
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 107 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 166
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 167 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 225
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 226 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 285
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
Query: 286 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 345
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
Query: 346 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 405
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
Query: 406 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 465
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
Query: 466 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 525
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
Query: 526 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 585
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
Query: 586 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 645
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
Query: 646 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 702
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
Query: 703 TAQEAL 708
A+EAL
Sbjct: 575 LAKEAL 580
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 190 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 249
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
Query: 250 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 309
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
Query: 310 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 369
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
Query: 370 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 429
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Query: 430 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 489
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
Query: 490 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 549
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
Query: 550 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 609
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Query: 610 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 669
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
Query: 670 RGPGHPPLPDKFQFELTLEEEEEE 693
R L +KFQFELTL+EE+ E
Sbjct: 497 R--DCQGLMEKFQFELTLDEEDSE 518
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 633
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 633
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 234 bits (598), Expect = 2e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 341 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 400
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
Query: 401 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 459
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
Query: 460 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 518
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
Query: 519 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 578
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
Query: 579 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 638
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
Query: 639 AQEILD 644
++D
Sbjct: 450 VSPLID 455
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 231 bits (590), Expect = 2e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 641
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 642 ILDTLEDNR 650
+ D ED++
Sbjct: 447 LAD--EDSK 453
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (549), Expect = 9e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 306 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 362
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 363 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 422
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 423 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 482
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 483 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 542
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 543 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 602
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 603 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 660
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
Query: 661 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 693
P + SRG PD E EE+E
Sbjct: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 339 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 398
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 399 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 458
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 459 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 517
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 518 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 566
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 567 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 625
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 626 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 666
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 783
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 339 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 398
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 399 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 458
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 459 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 517
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 518 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 566
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 567 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 625
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 626 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 666
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
Query: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
Query: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
Query: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
Query: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
+ +++ W H A ++ L DN
Sbjct: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 522 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 581
Query: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 582 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 641
Query: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 642 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 701
Query: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 702 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 759
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 760 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 819
Query: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
+ +++ W H A ++ L DN
Sbjct: 820 FITDMFDAWDAFAHLPA--LMQHLADN 844
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 487 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 546
Query: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 547 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 606
Query: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 607 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 666
Query: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 667 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 724
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 725 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
+ +++ W H A ++ L DN
Sbjct: 785 FITDMFDAWDAFAHLPA--LMQHLADN 809
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 445 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 504
Query: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 505 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 564
Query: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 565 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 624
Query: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 625 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 682
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 683 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 742
Query: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
+ +++ W H A ++ L DN
Sbjct: 743 FITDMFDAWDAFAHLPA--LMQHLADN 767
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 542 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 601
Query: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 602 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 661
Query: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 662 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 721
Query: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 722 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 779
Query: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 780 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 839
Query: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
+ +++ W H A ++ L DN
Sbjct: 840 FITDMFDAWDAFAHLPA--LMQHLADN 864
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (533), Expect = 7e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 403 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 462
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
Query: 463 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 522
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
Query: 523 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 582
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
Query: 583 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 632
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 3e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 403 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 462
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
Query: 463 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 522
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
Query: 523 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 582
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
Query: 583 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 623
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 178 bits (451), Expect = 2e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 343 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 399
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 400 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 427
Y D+ YHN +HA DVL + L P
Sbjct: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Query: 428 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 475
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
Query: 476 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 534
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
Query: 535 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 594
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
Query: 595 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 631
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 327 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 385
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 386 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 445
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 446 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 505
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 506 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 565
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 566 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 625
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 626 PLWETWADLVHPDAQEILDTLEDNRDWY 653
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 327 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 385
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 386 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 445
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 446 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 505
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 506 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 565
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 566 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 625
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 626 PLWETWADLVHPDAQEILDTLEDNRDWY 653
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,020,314
Number of Sequences: 37866
Number of extensions: 1983899
Number of successful extensions: 20616
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 17762
Number of HSP's gapped (non-prelim): 2684
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.