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Search of human proteins with 162287326
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
(491 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 1006 0.0
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 993 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 730 0.0
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 674 0.0
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 674 0.0
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 631 0.0
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 587 e-168
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 582 e-166
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 570 e-162
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 560 e-160
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 560 e-160
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 556 e-158
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 556 e-158
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 556 e-158
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 503 e-142
gi|4503787 fyn-related kinase [Homo sapiens] 469 e-132
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 350 1e-96
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 350 2e-96
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 348 5e-96
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 348 6e-96
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 348 6e-96
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 348 6e-96
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 348 6e-96
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 348 6e-96
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 336 2e-92
gi|148596974 TXK tyrosine kinase [Homo sapiens] 331 1e-90
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 322 6e-88
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 315 5e-86
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 309 3e-84
gi|187475373 c-src tyrosine kinase [Homo sapiens] 291 1e-78
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 1006 bits (2600), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 1 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD 60
MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD
Sbjct: 1 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD 60
Query: 61 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER 120
LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER
Sbjct: 61 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER 120
Query: 121 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF 180
QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF
Sbjct: 121 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF 180
Query: 181 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV 240
PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV
Sbjct: 181 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV 240
Query: 241 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY 300
WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY
Sbjct: 241 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY 300
Query: 301 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC 360
MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC
Sbjct: 301 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC 360
Query: 361 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK 420
KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
Sbjct: 361 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK 420
Query: 421 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 480
IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
Sbjct: 421 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 480
Query: 481 TATEGQYQQQP 491
TATEGQYQQQP
Sbjct: 481 TATEGQYQQQP 491
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 993 bits (2568), Expect = 0.0
Identities = 491/512 (95%), Positives = 491/512 (95%), Gaps = 21/512 (4%)
Query: 1 MGCIKSKGKDSLSDDGVDLKTQPV---------------------PESQLLPGQRFQTKD 39
MGCIKSKGKDSLSDDGVDLKTQPV PESQLLPGQRFQTKD
Sbjct: 1 MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60
Query: 40 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 99
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
Sbjct: 61 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 120
Query: 100 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 159
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
Sbjct: 121 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 180
Query: 160 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 219
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
Sbjct: 181 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 240
Query: 220 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 279
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
Sbjct: 241 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 300
Query: 280 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 339
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
Sbjct: 301 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 360
Query: 340 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 399
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
Sbjct: 361 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 420
Query: 400 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 459
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
Sbjct: 421 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 480
Query: 460 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 491
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Sbjct: 481 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 730 bits (1884), Expect = 0.0
Identities = 360/506 (71%), Positives = 419/506 (82%), Gaps = 16/506 (3%)
Query: 1 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG---QRFQTKDPEEQGD--- 45
MGC+KSK G ++ S P P S + PG T E G
Sbjct: 22 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDI 81
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLET 105
IVVALY Y+ IH +DLSF+KG++M VLEE GEWWKA+SL T+KEG+IPSNYVA++++LET
Sbjct: 82 IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLET 141
Query: 106 EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIR 165
EEWFFK I+RKDAERQLLAPGN G+F+IR+SET KGS+SLSVRD+DP GD +KHYKIR
Sbjct: 142 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIR 201
Query: 166 SLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRES 225
+LDNGG+YISPR TF + +++ HY+K DGLC++L C+S KPQKPW+KDAWEIPRES
Sbjct: 202 TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRES 261
Query: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285
+KL K+LGAGQFGEVWM YN TKVAVKT+KPG+MSV+AFL EAN+MKTLQHDKLV+L+
Sbjct: 262 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 321
Query: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345
AVVT+ EPIYIITE+MAKGSLLDFLKSDEG K LPKLIDFSAQIAEGMA+IE++NYIHR
Sbjct: 322 AVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 380
Query: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405
DLRAAN+LVS SL+CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG FTIKSDV
Sbjct: 381 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV 440
Query: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465
WSFGILL EIVTYG+IPYPG +N +V+ AL +GYRMPR ENCP+ELY+IM CWK + EE
Sbjct: 441 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE 500
Query: 466 RPTFDYLQSVLDDFYTATEGQYQQQP 491
RPTF+Y+QSVLDDFYTATE QYQQQP
Sbjct: 501 RPTFEYIQSVLDDFYTATESQYQQQP 526
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 674 bits (1738), Expect = 0.0
Identities = 316/449 (70%), Positives = 386/449 (85%), Gaps = 1/449 (0%)
Query: 43 QGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNT 102
Q ++V+AL+ Y+ H DL F+KGE++++LE+ GEWWKA+SL T +EGFIP N+VAK N+
Sbjct: 62 QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
Query: 103 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 162
LE E WFFK+++RKDAERQLLAPGN+ G+FLIRESE+ GSFSLSVRDFD G+V+KHY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
Query: 163 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 222
KIR+LDNGG+YISPRITFP + ++++HY +DGLC RL + C + KPQKPW +D WE+P
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
Query: 223 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 282
RE++KLV+RLGAGQFGEVWMGYYN TKVAVK+LK G+MS AFL EANLMK LQH +LV
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 283 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 342
RLYAVVT +EPIYIITEYM GSL+DFLK+ G K+ + KL+D +AQIAEGMA+IE +NY
Sbjct: 302 RLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
Query: 343 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 402
IHRDLRAAN+LVS++L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G FTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
Query: 403 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 462
SDVWSFGILL EIVT+G+IPYPG TN +V+ L +GYRM R +NCP+ELY +M++CWKE+
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
Query: 463 AEERPTFDYLQSVLDDFYTATEGQYQQQP 491
E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 674 bits (1738), Expect = 0.0
Identities = 316/449 (70%), Positives = 386/449 (85%), Gaps = 1/449 (0%)
Query: 43 QGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNT 102
Q ++V+AL+ Y+ H DL F+KGE++++LE+ GEWWKA+SL T +EGFIP N+VAK N+
Sbjct: 62 QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
Query: 103 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 162
LE E WFFK+++RKDAERQLLAPGN+ G+FLIRESE+ GSFSLSVRDFD G+V+KHY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
Query: 163 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 222
KIR+LDNGG+YISPRITFP + ++++HY +DGLC RL + C + KPQKPW +D WE+P
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
Query: 223 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 282
RE++KLV+RLGAGQFGEVWMGYYN TKVAVK+LK G+MS AFL EANLMK LQH +LV
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 283 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 342
RLYAVVT +EPIYIITEYM GSL+DFLK+ G K+ + KL+D +AQIAEGMA+IE +NY
Sbjct: 302 RLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
Query: 343 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 402
IHRDLRAAN+LVS++L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G FTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
Query: 403 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 462
SDVWSFGILL EIVT+G+IPYPG TN +V+ L +GYRM R +NCP+ELY +M++CWKE+
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
Query: 463 AEERPTFDYLQSVLDDFYTATEGQYQQQP 491
E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 631 bits (1627), Expect = 0.0
Identities = 310/494 (62%), Positives = 386/494 (78%), Gaps = 9/494 (1%)
Query: 4 IKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDP-----EEQGDIVVALYPYDGIHP 58
IK K K S V + + P L T P +E VVALY Y ++
Sbjct: 15 IKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMND 74
Query: 59 DDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDA 118
DL KGEK++VL+ G+WW A+SL+T +EG++PSN+VA++ +LE E WFF+ RK+A
Sbjct: 75 RDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEA 134
Query: 119 ERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRI 178
ERQLLAP N AG+FLIRESET KG+FSLSV+D G++IKHYKIR LD GGYYISPRI
Sbjct: 135 ERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRI 193
Query: 179 TFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFG 238
TFP + +++HY K+ DGLC+RL C+ P PQ PW +D WEIPR+S++LV++LG+GQFG
Sbjct: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFG 253
Query: 239 EVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIIT 298
EVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK LQH++LVRLYAVVT+ EPIYI+T
Sbjct: 254 EVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTK-EPIYIVT 312
Query: 299 EYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL 358
EYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMAYIER N IHRDLRAAN+LVSE+L
Sbjct: 313 EYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL 372
Query: 359 MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTY 418
CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+FG FTIK+DVWSFG+LL E+VTY
Sbjct: 373 CCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTY 431
Query: 419 GKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DIMKMCWKEKAEERPTFDYLQSVLD 477
G++PYPG +N +V+ L +GYRMPR + CP ELY ++ CW+ + EERPTF++LQSVL+
Sbjct: 432 GRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
Query: 478 DFYTATEGQYQQQP 491
DFYTATE QY+ QP
Sbjct: 492 DFYTATERQYELQP 505
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 587 bits (1513), Expect = e-168
Identities = 277/445 (62%), Positives = 355/445 (79%), Gaps = 3/445 (0%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
I VALY Y+ +DLSFKKGE+ +++ G+WW+A+S+ T K G+IPSNYVA ++++
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F + RKDAER LL PGN G FL+RESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPR 223
R LDNGGYYI+ R F + ++KHY + ADGLC +L C + KPQ + KDAWEIPR
Sbjct: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
Query: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
ES++L +LG G FGEVWMG +N +TKVA+KTLKPGTM +AFL+EA +MK L+HDKLV
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
Query: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
LYAVV+ EEPIYI+TE+M+KGSLLDFLK +G + LP+L+D +AQIA+GMAYIER NYI
Sbjct: 335 LYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 393
Query: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
HRDLRAAN+LV E+L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 394 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 453
Query: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
DVWSFGIL E+VT G++PYPG N +V+ + +GYRMP + CP+ L+++M +CWK+
Sbjct: 454 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 513
Query: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
+ERPTF+Y+QS L+D++TATE QYQ
Sbjct: 514 DERPTFEYIQSFLEDYFTATEPQYQ 538
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 582 bits (1500), Expect = e-166
Identities = 281/448 (62%), Positives = 352/448 (78%), Gaps = 6/448 (1%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ----KPWDKDAWE 220
R LDNGGYYI+ R F + +++HY ++A GLC RL C P+ KD WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
Query: 221 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 280
IPRES++L+KRLG GQFGEVWMG +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDK
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
Query: 281 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 340
LV+LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER
Sbjct: 326 LVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384
Query: 341 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 400
NYIHRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FT
Sbjct: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444
Query: 401 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 460
IKSDVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK
Sbjct: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504
Query: 461 EKAEERPTFDYLQSVLDDFYTATEGQYQ 488
+ EERPTF+YLQS L+D++TATE QYQ
Sbjct: 505 KDPEERPTFEYLQSFLEDYFTATEPQYQ 532
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 570 bits (1468), Expect = e-162
Identities = 276/445 (62%), Positives = 347/445 (77%), Gaps = 3/445 (0%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW-DKDAWEIPR 223
R LDNGGYYI+ R F + +++HY ++ADGLC L S PQ KDAWE+ R
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
Query: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
S+ L K+LG G F EVW+G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+
Sbjct: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
Query: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYI
Sbjct: 326 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 384
Query: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
HRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 385 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 444
Query: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
DVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+
Sbjct: 445 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 504
Query: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
EERPTF+YLQS L+D++TATE QYQ
Sbjct: 505 EERPTFEYLQSFLEDYFTATEPQYQ 529
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 560 bits (1444), Expect = e-160
Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)
Query: 48 VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 106
VALY Y+ DLSFKKGE+++++ G+WW A SL T + G+IPSNYVA ++++ E
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 107 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 166
EW+F ITR+++ER LL N G FL+RESET KG++ LSV DFD G +KHYKIR
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 167 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 225
LD+GG+YI+ R F + ++ +Y K ADGLC RL C + KPQ + KDAWEIPRES
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
Query: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285
++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345
AVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
Query: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405
DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSDV
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
Query: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465
WSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L+D+M CW+++ EE
Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
Query: 466 RPTFDYLQSVLDDFYTATEGQYQ 488
RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 560 bits (1444), Expect = e-160
Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)
Query: 48 VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 106
VALY Y+ DLSFKKGE+++++ G+WW A SL T + G+IPSNYVA ++++ E
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 107 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 166
EW+F ITR+++ER LL N G FL+RESET KG++ LSV DFD G +KHYKIR
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 167 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 225
LD+GG+YI+ R F + ++ +Y K ADGLC RL C + KPQ + KDAWEIPRES
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
Query: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285
++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345
AVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
Query: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405
DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSDV
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
Query: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465
WSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L+D+M CW+++ EE
Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
Query: 466 RPTFDYLQSVLDDFYTATEGQYQ 488
RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 556 bits (1434), Expect = e-158
Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ +ALY Y+ DDL+F KGEK +L G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F I RKDAERQLL+PGN GAFLIRESET KG++SLS+RD+D GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 223
R LD GGYYI+ R+ F + ++++HY + DGLC L C KPQ KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
Query: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
Query: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
LYAVV+ EEPIYI+TE+M GSLLDFLK+ EG + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
Query: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
HRDLRAAN+LV E L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439
Query: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
DVWSFGILL E++T G+IPYPG +V+ + QGY MP CP LY+ M+ W+
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499
Query: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 556 bits (1434), Expect = e-158
Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ +ALY Y+ DDL+F KGEK +L G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F I RKDAERQLL+PGN GAFLIRESET KG++SLS+RD+D GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 223
R LD GGYYI+ R+ F + ++++HY + DGLC L C KPQ KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
Query: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
Query: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
LYAVV+ EEPIYI+TE+M GSLLDFLK+ EG + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
Query: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
HRDLRAAN+LV E L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439
Query: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
DVWSFGILL E++T G+IPYPG +V+ + QGY MP CP LY+ M+ W+
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499
Query: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 556 bits (1434), Expect = e-158
Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ +ALY Y+ DDL+F KGEK +L G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F I RKDAERQLL+PGN GAFLIRESET KG++SLS+RD+D GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 223
R LD GGYYI+ R+ F + ++++HY + DGLC L C KPQ KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
Query: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
Query: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
LYAVV+ EEPIYI+TE+M GSLLDFLK+ EG + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
Query: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
HRDLRAAN+LV E L CKIADFGLAR+I+D+EY +G+KFPIKWTAPEA FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439
Query: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
DVWSFGILL E++T G+IPYPG +V+ + QGY MP CP LY+ M+ W+
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499
Query: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 503 bits (1296), Expect = e-142
Identities = 251/444 (56%), Positives = 316/444 (71%), Gaps = 53/444 (11%)
Query: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRE 224
R LDNGGYYI+ R F + +++HY
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
Query: 225 SIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRL 284
G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+L
Sbjct: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
Query: 285 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 344
YAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYIH
Sbjct: 275 YAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 333
Query: 345 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSD 404
RDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSD
Sbjct: 334 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 393
Query: 405 VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAE 464
VWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+ E
Sbjct: 394 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 453
Query: 465 ERPTFDYLQSVLDDFYTATEGQYQ 488
ERPTF+YLQS L+D++TATE QYQ
Sbjct: 454 ERPTFEYLQSFLEDYFTATEPQYQ 477
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 469 bits (1206), Expect = e-132
Identities = 240/463 (51%), Positives = 319/463 (68%), Gaps = 22/463 (4%)
Query: 41 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEG-------FI 92
+ G VAL+ Y +DLSF+ G+K++VL+ H WW A+ L +++G +I
Sbjct: 41 QRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYI 100
Query: 93 PSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 152
PSNYVA+ +L+ E WFF I R DAE+QLL N G+FLIRESE+ KG FSLSV D
Sbjct: 101 PSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-- 158
Query: 153 PVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK 212
G V+KHY+I+ LD GG++++ R F +++ + HY K +DGLC +L K C+ +
Sbjct: 159 ---GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPA 215
Query: 213 PWDK-----DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFL 267
P+D D WEI R SI+L+KRLG+GQFGEVW G +NN+T VAVKTLKPG+M FL
Sbjct: 216 PFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL 275
Query: 268 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 327
EA +MK L+H KL++LYAV T E+PIYIITE M GSL ++L++D G K+ L + +D +
Sbjct: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMA 335
Query: 328 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNE--YTAREGAKF 384
AQ+A GMAY+E +NYIHRDL A NVLV E + K+ADFGLARV + DNE Y +R K
Sbjct: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395
Query: 385 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV 444
P+KWTAPEAI F+IKSDVWSFGILLYEI+TYGK+PY G T A V+ L+Q YR+P+
Sbjct: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455
Query: 445 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 487
NCP + Y+IM CW + +ERPTF+ L+ L+D++ T+ Y
Sbjct: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 350 bits (899), Expect = 1e-96
Identities = 199/500 (39%), Positives = 295/500 (59%), Gaps = 31/500 (6%)
Query: 1 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLP-----GQRFQTKD------PEEQGDIVVA 49
+GC KG S S ++ Q S P R+ +K+ E ++ VA
Sbjct: 9 VGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVA 68
Query: 50 LYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE 107
LY + + LS KGEK++VL +GEW +A++ +G++PSNY+ +N+LE
Sbjct: 69 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSLEKHS 126
Query: 108 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL 167
W+ ++R AE LL+ G + G+FL+RESE+ G S+S+R V+ HY+I +
Sbjct: 127 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY-----HYRINTA 179
Query: 168 DNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW------DKDAWEI 221
+G Y+S F +++++ H+ ADGL L +PK KP + D WE+
Sbjct: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGVSPNYDKWEM 237
Query: 222 PRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 280
R I + +LG GQ+GEV+ G + S VAVKTLK TM V+ FL+EA +MK ++H
Sbjct: 238 ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 297
Query: 281 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 340
LV+L V TRE P YIITE+M G+LLD+L+ +V L+ + QI+ M Y+E+K
Sbjct: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
Query: 341 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 400
N+IHRDL A N LV E+ + K+ADFGL+R++ + YTA GAKFPIKWTAPE++ + F+
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
Query: 401 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 460
IKSDVW+FG+LL+EI TYG PYPG + V L + YRM R E CP+++Y++M+ CW+
Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
Query: 461 EKAEERPTFDYLQSVLDDFY 480
+RP+F + + +
Sbjct: 478 WNPSDRPSFAEIHQAFETMF 497
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 350 bits (897), Expect = 2e-96
Identities = 185/463 (39%), Positives = 275/463 (59%), Gaps = 19/463 (4%)
Query: 17 VDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG 76
+D T PVP P F + +ALY + +LS ++G+++ LEE G
Sbjct: 34 LDPNTDPVPTLPAEPCSPFP--------QLFLALYDFTARCGGELSVRRGDRLCALEEGG 85
Query: 77 EWWKAKSLLTKKE-GFIPSNYVAKLN--TLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
+ A+ L + G +P +VAK + TL + W+F ++R A++ LL+P N GAFL
Sbjct: 86 GYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFL 145
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
IR SE+ G +SLSVR V HY++ +G Y+ FP + +++ +Y+
Sbjct: 146 IRPSESSLGGYSLSVRAQAKVC-----HYRVSMAADGSLYLQKGRLFPGLEELLTYYKAN 200
Query: 194 ADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAV 253
+ L + C+ PQK +D WE P L ++LG G FGEVW G + S VA+
Sbjct: 201 WKLIQNPLLQPCM---PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAI 257
Query: 254 KTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD 313
K +K M + +E +K L+H++L+RL+AV + EP+YI+TE M KG+L FL +
Sbjct: 258 KVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTP 317
Query: 314 EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED 373
EG + LP L+ F+ Q+AEGM+Y+E + +HRDL A NVLV + L CK+ADFGLAR+++D
Sbjct: 318 EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKD 377
Query: 374 NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMT 433
+ Y+ +K P+KWTAPEA N+ F+ KSDVWSFG+LL+E+ TYG+ PY G TN + +
Sbjct: 378 DIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQ 437
Query: 434 ALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVL 476
+ +GYR+PR CP E+Y +M CW+ EERP+F L+ L
Sbjct: 438 QIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 348 bits (894), Expect = 5e-96
Identities = 188/449 (41%), Positives = 278/449 (61%), Gaps = 20/449 (4%)
Query: 41 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 98
E ++ VALY + + LS KGEK++VL +GEW +A++ +G++PSNY+
Sbjct: 79 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 136
Query: 99 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 158
+N+LE W+ ++R AE LL+ G + G+FL+RESE+ G S+S+R V+
Sbjct: 137 PVNSLEKHSWYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY--- 191
Query: 159 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW---- 214
HY+I + +G Y+S F +++++ H+ ADGL L +PK KP
Sbjct: 192 --HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGV 247
Query: 215 --DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 271
+ D WE+ R I + +LG GQ+GEV+ G + S VAVKTLK TM V+ FL+EA
Sbjct: 248 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 307
Query: 272 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 331
+MK ++H LV+L V TRE P YIITE+M G+LLD+L+ +V L+ + QI+
Sbjct: 308 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 367
Query: 332 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 391
M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++ + YTA GAKFPIKWTAP
Sbjct: 368 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 427
Query: 392 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 451
E++ + F+IKSDVW+FG+LL+EI TYG PYPG + V L + YRM R E CP+++
Sbjct: 428 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 487
Query: 452 YDIMKMCWKEKAEERPTFDYLQSVLDDFY 480
Y++M+ CW+ +RP+F + + +
Sbjct: 488 YELMRACWQWNPSDRPSFAEIHQAFETMF 516
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 348 bits (893), Expect = 6e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 66 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 125
Query: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 126 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 181
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 182 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 236
Query: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 237 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 294
Query: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 295 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 354
Query: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 355 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 415 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 474
Query: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 475 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 348 bits (893), Expect = 6e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 81 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 140
Query: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 141 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 196
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 197 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 251
Query: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 252 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 309
Query: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 310 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369
Query: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 370 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 430 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 489
Query: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 490 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 348 bits (893), Expect = 6e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 60 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 119
Query: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 120 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 175
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 176 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 230
Query: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 231 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 288
Query: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 289 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 348
Query: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 349 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 408
Query: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 409 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 468
Query: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 469 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 348 bits (893), Expect = 6e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 66 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 125
Query: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 126 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 181
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 182 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 236
Query: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 237 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 294
Query: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 295 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 354
Query: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 355 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 415 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 474
Query: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 475 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 348 bits (893), Expect = 6e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 45 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 104
Query: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 105 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 160
Query: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 161 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 215
Query: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 216 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 273
Query: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 274 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 333
Query: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 334 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 393
Query: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 394 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 453
Query: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 454 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 496
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 336 bits (862), Expect = 2e-92
Identities = 177/449 (39%), Positives = 272/449 (60%), Gaps = 13/449 (2%)
Query: 37 TKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKK-----EGF 91
++D G V L+ + ++LSF+ G+ V + +WW A +LL + +G+
Sbjct: 3 SRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWA-TLLDEAGGAVAQGY 61
Query: 92 IPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDF 151
+P NY+A+ T+E+E WFF I+R +A R+L A GN+ GAFLIR SE + LSVRD
Sbjct: 62 VPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT 121
Query: 152 DPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ 211
V +HYKI G +++ ++F + +++ +++ Q+ RL C +P+
Sbjct: 122 QAV-----RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE 176
Query: 212 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLE-EA 270
D WE PRE L ++LG+G FGEV+ G + + +VA+K + + Q L+ E
Sbjct: 177 PLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEI 236
Query: 271 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 330
MK L+H ++ LYAVV+ +P+YIITE MAKGSLL+ L+ + + + +L+D + Q+
Sbjct: 237 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQV 296
Query: 331 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 390
AEGM Y+E +NYIHRDL A N+LV E+ +CK+ DFGLAR+I+++ Y + + P KWTA
Sbjct: 297 AEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTA 355
Query: 391 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 450
PEA++ G ++ KSDVWSFGILL+E+ + G++PYPG +N + + GYRMP CP
Sbjct: 356 PEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPS 415
Query: 451 LYDIMKMCWKEKAEERPTFDYLQSVLDDF 479
++ +M CW E+RP F L+ L F
Sbjct: 416 VHKLMLTCWCRDPEQRPCFKALRERLSSF 444
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 331 bits (848), Expect = 1e-90
Identities = 179/437 (40%), Positives = 269/437 (61%), Gaps = 24/437 (5%)
Query: 47 VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVA--KLNTL 103
V ALY + P +L+ ++ E+ +LE++ WWKA+ L EG IPSNYV K+ L
Sbjct: 87 VKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGN-EGLIPSNYVTENKITNL 145
Query: 104 ETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSV-----RDFDPVHGDV 158
E EW+ ++ITR AE LL + GAF++R+S L GS+++SV R +
Sbjct: 146 EIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAA---- 199
Query: 159 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEK------ACISPKPQK 212
IKHY+I+ D+G +Y++ R F I ++I ++Q A GL RL +C+
Sbjct: 200 IKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGF 259
Query: 213 PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANL 272
++K WEI + +K +G+GQFG V +G + + +VA+K + G+MS + F+EEA +
Sbjct: 260 SYEK--WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKV 317
Query: 273 MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAE 332
M L H KLV+LY V + +P+YI+TE+M G LL++L+ ++G K+ L+ I E
Sbjct: 318 MMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQDICE 376
Query: 333 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPE 392
GM Y+ER YIHRDL A N LVS + + KI+DFG+ R + D+EY + GAKFPIKW+ PE
Sbjct: 377 GMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPE 436
Query: 393 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY 452
F ++ KSDVWSFG+L++E+ T GK+P+ ++N V+ A+S+G+R+ R P +Y
Sbjct: 437 VFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIY 496
Query: 453 DIMKMCWKEKAEERPTF 469
++M CW EK E RPTF
Sbjct: 497 EVMYSCWHEKPEGRPTF 513
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 322 bits (824), Expect = 6e-88
Identities = 175/441 (39%), Positives = 269/441 (60%), Gaps = 16/441 (3%)
Query: 47 VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVAKL-NTLE 104
VVALY Y ++ +DL +KG++ +LEE WW+A+ +EG+IPSNYV + +++E
Sbjct: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIE 277
Query: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VIKH 161
EW+ K +TR AE QLL G F++R+S G +++SV F GD VI+H
Sbjct: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333
Query: 162 YKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKD---- 217
Y + S YY++ + F I ++I ++Q + GL RL+ P
Sbjct: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393
Query: 218 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 277
+WEI + + +K LG GQFG V G + VA+K +K G+MS F+EEA +M L
Sbjct: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453
Query: 278 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 337
H+KLV+LY V T++ PI+IITEYMA G LL++L+ + + +L++ + E M Y+
Sbjct: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYL 512
Query: 338 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 397
E K ++HRDL A N LV++ + K++DFGL+R + D+EYT+ G+KFP++W+ PE + +
Sbjct: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572
Query: 398 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 457
F+ KSD+W+FG+L++EI + GK+PY TN++ ++QG R+ R +++Y IM
Sbjct: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632
Query: 458 CWKEKAEERPTFDYLQS-VLD 477
CW EKA+ERPTF L S +LD
Sbjct: 633 CWHEKADERPTFKILLSNILD 653
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 315 bits (808), Expect = 5e-86
Identities = 172/487 (35%), Positives = 283/487 (58%), Gaps = 15/487 (3%)
Query: 9 KDSLSDDGVDLKTQPVPESQLL-PGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGE 67
K +L + + P PE++ P ++ + +IVVA+Y + DL ++G+
Sbjct: 145 KYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQ 204
Query: 68 KMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLA 124
+ +LE++ WW+A+ EG+IPSNYV K N L+ EW+ +++ R AE QLL
Sbjct: 205 EYLILEKNDVHWWRARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLR 262
Query: 125 PGNSAGAFLIRESETLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFP 181
+ G F++R+S G +++S+ F +HY I+ YY++ + F
Sbjct: 263 SEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFG 321
Query: 182 CISDMIKHYQKQADGLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQF 237
I ++I++++ A GL RL P + + WEI + ++ LG+G F
Sbjct: 322 SIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLF 381
Query: 238 GEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYII 297
G V +G + KVA+K ++ G M + F+EEA +M L H KLV+LY V T+++PIYI+
Sbjct: 382 GVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIV 441
Query: 298 TEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSES 357
TE+M +G LL+FL+ +G L+ + EGM Y+ER ++IHRDL A N LVSE+
Sbjct: 442 TEFMERGCLLNFLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEA 500
Query: 358 LMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVT 417
+ K++DFG+AR + D++YT+ GAKFP+KW PE N+ F+ KSDVWSFG+L++E+ T
Sbjct: 501 GVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFT 560
Query: 418 YGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477
G++P+ TN +V+T +++G+R+ + + + +Y++M CW+EK E RP+F+ L +D
Sbjct: 561 EGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTID 620
Query: 478 DFYTATE 484
+ E
Sbjct: 621 ELVECEE 627
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 309 bits (792), Expect = 3e-84
Identities = 172/461 (37%), Positives = 264/461 (57%), Gaps = 22/461 (4%)
Query: 23 PVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKA 81
P PE P +PEE +V+ALY Y P +L+ ++ E+ +L+ WW+
Sbjct: 159 PTPEDNRRP-----LWEPEET--VVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRV 211
Query: 82 KSLLTKKEGFIPSNYVAKL--NTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESET 139
+ EG++PS+Y+ + N LET EW+ K I+R AE+ LL G GAF++R+S T
Sbjct: 212 QDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFMVRDSRT 269
Query: 140 LKGSFSLSVRDFDPV--HGDVIKHYKIRSLDNGG--YYISPRITFPCISDMIKHYQKQAD 195
G++++SV V + IKHY I+ ++ YY++ + F I +I ++Q
Sbjct: 270 A-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGG 328
Query: 196 GLCRRLEKACISPKPQKPWDKDA----WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 251
GL RL + + P W I + V+ +G+GQFG V +GY+ N KV
Sbjct: 329 GLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKV 388
Query: 252 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 311
A+KT++ G MS + F+EEA +M L H KLV+LY V + PI ++ E+M G L D+L+
Sbjct: 389 AIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR 448
Query: 312 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 371
+ G L+ + EGMAY+E IHRDL A N LV E+ + K++DFG+ R +
Sbjct: 449 TQRG-LFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV 507
Query: 372 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 431
D++YT+ G KFP+KW +PE +F ++ KSDVWSFG+L++E+ + GKIPY R+N++V
Sbjct: 508 LDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEV 567
Query: 432 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYL 472
+ +S G+R+ + +Y IM CWKE+ E+RP F L
Sbjct: 568 VEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 291 bits (744), Expect = 1e-78
Identities = 174/451 (38%), Positives = 254/451 (56%), Gaps = 29/451 (6%)
Query: 44 GDIVVALYPYDGIHPDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLN 101
G +A Y + G DL F KG+ + ++ + W+KAK+ + + EG IP+NYV K
Sbjct: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKRE 69
Query: 102 ------TLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVR-DFDPV 154
L WF ITR+ AER L P G FL+RES G ++L V D
Sbjct: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVE 127
Query: 155 HGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACI---SPKPQ 211
H ++ H S+D Y F + +++HY ADGLC RL K + + Q
Sbjct: 128 HYRIMYHASKLSIDEEVY-------FENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
Query: 212 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 271
+ + W + + +KL++ +G G+FG+V +G Y + KVAVK +K + QAFL EA+
Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEAS 238
Query: 272 LMKTLQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 330
+M L+H LV+L V+ E+ +YI+TEYMAKGSL+D+L+S + L+ FS +
Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298
Query: 331 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 390
E M Y+E N++HRDL A NVLVSE + K++DFGL + + T K P+KWTA
Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354
Query: 391 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 450
PEA+ F+ KSDVWSFGILL+EI ++G++PYP DV+ + +GY+M + CP
Sbjct: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414
Query: 451 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYT 481
+Y++MK CW A RP+F L+ L+ T
Sbjct: 415 VYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,189,748
Number of Sequences: 37866
Number of extensions: 873805
Number of successful extensions: 4566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 308
Number of HSP's that attempted gapping in prelim test: 2064
Number of HSP's gapped (non-prelim): 1282
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.