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Search of human proteins with 15826852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
(528 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa... 1066 0.0
gi|47106067 transmembrane emp24 protein transport domain contain... 197 2e-50
gi|56549694 enabled homolog isoform a [Homo sapiens] 79 8e-15
gi|39930375 enabled homolog isoform b [Homo sapiens] 79 8e-15
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 79 1e-14
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 75 1e-13
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 75 1e-13
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 74 4e-13
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 74 4e-13
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 74 4e-13
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 74 4e-13
gi|148746195 trichohyalin [Homo sapiens] 72 1e-12
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 71 2e-12
gi|221139761 zinc finger protein 853 [Homo sapiens] 69 8e-12
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 69 8e-12
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 69 8e-12
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 69 8e-12
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 69 8e-12
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 69 1e-11
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 69 1e-11
gi|154354979 myosin X [Homo sapiens] 68 2e-11
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 68 2e-11
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 67 5e-11
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 67 5e-11
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 67 5e-11
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 67 5e-11
gi|92859701 myosin VI [Homo sapiens] 66 7e-11
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 66 7e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 65 1e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 64 3e-10
>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
Length = 528
Score = 1066 bits (2758), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEP 60
MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEP
Sbjct: 1 MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEP 60
Query: 61 GEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVL 120
GEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVL
Sbjct: 61 GEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVL 120
Query: 121 MGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHK 180
MGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHK
Sbjct: 121 MGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHK 180
Query: 181 IEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
IEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE
Sbjct: 181 IEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ
Sbjct: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Query: 301 QAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALEN 360
QAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALEN
Sbjct: 301 QAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALEN 360
Query: 361 GPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEF 420
GPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEF
Sbjct: 361 GPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEF 420
Query: 421 ATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIV 480
ATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIV
Sbjct: 421 ATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIV 480
Query: 481 PVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR 528
PVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR
Sbjct: 481 PVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR 528
>gi|47106067 transmembrane emp24 protein transport domain containing
8 [Homo sapiens]
Length = 325
Score = 197 bits (501), Expect = 2e-50
Identities = 98/230 (42%), Positives = 145/230 (63%), Gaps = 9/230 (3%)
Query: 307 QQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESL 366
+Q+++ A + + VP + HT + + + + L + K S
Sbjct: 95 KQDLLPADQAQVLNEMAKYQVPQRSGDIVMIQSEHTGAIDVLSADLESADLLGDHRKVSP 154
Query: 367 PVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYD 426
P++A P +WT ++K+FK K+ ++ +S + V RGEVVT+RVPTH EG + WEFATD+YD
Sbjct: 155 PLMAPPCIWTFAKVKEFKSKLGKEKNSRLVVKRGEVVTIRVPTHPEGKRVCWEFATDDYD 214
Query: 427 IGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEEN---------IGCEEKAKKNANKPLLD 477
IGFGVYF+WT +T ++V VS+SSDD++EEEE G E+ +++ +
Sbjct: 215 IGFGVYFDWTPVTSTDITVQVSDSSDDEDEEEEEEEEIEEPVPAGDVERGSRSSLRGRYG 274
Query: 478 EIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 527
E++PVYRRD H +V AGSH YPG G+YLLKFDNSYSL R+K++Y+ +YYT
Sbjct: 275 EVMPVYRRDSHRDVQAGSHDYPGEGIYLLKFDNSYSLLRNKTLYFHIYYT 324
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 79.3 bits (194), Expect = 8e-15
Identities = 54/184 (29%), Positives = 103/184 (55%), Gaps = 14/184 (7%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+EE E +R++ +E++R++E ERERL++E +R R E ERL RE ER R+E+E+L E+Q
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
+++ L Q ++ Q+ +Q + E+Q+ R+ E+ ++ ++ Q QL ++Q
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 303 ALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGP 362
++++ + +S+ A+V + + SV G DSS E +AA + E
Sbjct: 257 EWERERRI--------SSAAAPASVETPLNSVLG------DSSASEPGLQAASQPAETPS 302
Query: 363 KESL 366
++ +
Sbjct: 303 QQGI 306
Score = 53.1 bits (126), Expect = 6e-07
Identities = 31/90 (34%), Positives = 58/90 (64%), Gaps = 12/90 (13%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEER----ERLQKEE-------EKRRREEEERLRREEEE 228
++E+E+ E++R+E E + R E +ER ERL+++E E++ RE ERL RE +E
Sbjct: 185 RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE 244
Query: 229 RRRIEE-ERLRLEQQKQQIMAALNSQTAVQ 257
R R E+ ER +LE ++++ +++ + +V+
Sbjct: 245 RERQEQLEREQLEWERERRISSAAAPASVE 274
Score = 36.6 bits (83), Expect = 0.058
Identities = 21/51 (41%), Positives = 24/51 (47%), Gaps = 4/51 (7%)
Query: 13 SVDGLTLSPDPEERPGAEG---APLLPPPLPPPSPPGSGRGPGASGEQPEP 60
S GL + P E P +G PL PPP PPP PPG + A P P
Sbjct: 287 SEPGLQAASQPAETPSQQGIVLGPLAPPP-PPPLPPGPAQASVALPPPPGP 336
Score = 29.6 bits (65), Expect = 7.1
Identities = 16/33 (48%), Positives = 16/33 (48%), Gaps = 2/33 (6%)
Query: 21 PDPEERPGAEGAP--LLPPPLPPPSPPGSGRGP 51
P P PG A L PPP PPP PP GP
Sbjct: 315 PPPPLPPGPAQASVALPPPPGPPPPPPLPSTGP 347
Score = 29.6 bits (65), Expect = 7.1
Identities = 16/46 (34%), Positives = 18/46 (39%)
Query: 21 PDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEPGEAAAG 66
P P P P PP PPP PP + P P P A+G
Sbjct: 331 PPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASG 376
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 79.3 bits (194), Expect = 8e-15
Identities = 54/184 (29%), Positives = 103/184 (55%), Gaps = 14/184 (7%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+EE E +R++ +E++R++E ERERL++E +R R E ERL RE ER R+E+E+L E+Q
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
+++ L Q ++ Q+ +Q + E+Q+ R+ E+ ++ ++ Q QL ++Q
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 303 ALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGP 362
++++ + +S+ A+V + + SV G DSS E +AA + E
Sbjct: 257 EWERERRI--------SSAAAPASVETPLNSVLG------DSSASEPGLQAASQPAETPS 302
Query: 363 KESL 366
++ +
Sbjct: 303 QQGI 306
Score = 53.1 bits (126), Expect = 6e-07
Identities = 31/90 (34%), Positives = 58/90 (64%), Gaps = 12/90 (13%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEER----ERLQKEE-------EKRRREEEERLRREEEE 228
++E+E+ E++R+E E + R E +ER ERL+++E E++ RE ERL RE +E
Sbjct: 185 RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE 244
Query: 229 RRRIEE-ERLRLEQQKQQIMAALNSQTAVQ 257
R R E+ ER +LE ++++ +++ + +V+
Sbjct: 245 RERQEQLEREQLEWERERRISSAAAPASVE 274
Score = 36.6 bits (83), Expect = 0.058
Identities = 21/51 (41%), Positives = 24/51 (47%), Gaps = 4/51 (7%)
Query: 13 SVDGLTLSPDPEERPGAEG---APLLPPPLPPPSPPGSGRGPGASGEQPEP 60
S GL + P E P +G PL PPP PPP PPG + A P P
Sbjct: 287 SEPGLQAASQPAETPSQQGIVLGPLAPPP-PPPLPPGPAQASVALPPPPGP 336
Score = 29.6 bits (65), Expect = 7.1
Identities = 16/33 (48%), Positives = 16/33 (48%), Gaps = 2/33 (6%)
Query: 21 PDPEERPGAEGAP--LLPPPLPPPSPPGSGRGP 51
P P PG A L PPP PPP PP GP
Sbjct: 315 PPPPLPPGPAQASVALPPPPGPPPPPPLPSTGP 347
Score = 29.6 bits (65), Expect = 7.1
Identities = 16/46 (34%), Positives = 18/46 (39%)
Query: 21 PDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEPGEAAAG 66
P P P P PP PPP PP + P P P A+G
Sbjct: 331 PPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASG 376
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 79.0 bits (193), Expect = 1e-14
Identities = 47/134 (35%), Positives = 83/134 (61%), Gaps = 11/134 (8%)
Query: 180 KIEKEEQEKKRKEEEERR----RREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
+IE+++++++R EE++RR RR++E +R +++EEKRR EE ER R+EEEERRR EEE
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ-QLYQ 294
+ R+E++++ I L +Q + Q+Q ++ + + + +++ Q + Q
Sbjct: 458 KRRVEREQEYIRRQLEE------EQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQ 511
Query: 295 VQLAQQQAALQKQQ 308
QL Q+QA L Q
Sbjct: 512 RQLQQEQAYLLSLQ 525
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/123 (35%), Positives = 79/123 (64%), Gaps = 12/123 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+E++E KR+ ER++R E+++E+ ++ EE++RRE E R ++E E+RRR +EE+ RLE+
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEE- 440
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILI-RQLQEQHYQQYMQQLYQVQLAQQQ 301
L + + ++ A++ E++Q I RQL+E+ Q++++ L Q QL Q+Q
Sbjct: 441 -------LERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE--QRHLEVLQQ-QLLQEQ 490
Query: 302 AAL 304
A L
Sbjct: 491 AML 493
Score = 64.7 bits (156), Expect = 2e-10
Identities = 36/123 (29%), Positives = 73/123 (59%), Gaps = 3/123 (2%)
Query: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQ 244
E++K+ ++++E+RRR EE++ R E E RR++E E+ RRE+EE+RR+EE R +++++
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRR---EREARRQQEREQRRREQEEKRRLEELERRRKEEEE 450
Query: 245 QIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAAL 304
+ A + + Q+Y +Q ++L +QL ++ + +++ +Q L
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERL 510
Query: 305 QKQ 307
Q+Q
Sbjct: 511 QRQ 513
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/127 (24%), Positives = 63/127 (49%), Gaps = 3/127 (2%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
K+ ++ RK+ E+ E E ++EEE +E E + + LRL+Q+
Sbjct: 303 KDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE 362
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
++ AL Q +Q QQ Q+ Y++Q + RQ + + ++ ++L + Q +++A
Sbjct: 363 NKERSEALRRQQLLQEQQLREQE---EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 303 ALQKQQE 309
Q+++E
Sbjct: 420 RRQQERE 426
Score = 43.5 bits (101), Expect = 5e-04
Identities = 48/184 (26%), Positives = 84/184 (45%), Gaps = 21/184 (11%)
Query: 183 KEEQEKKRKEEEERR-RREEEERERLQKEEEKRRRE--EEERLR----------REEEER 229
KEE+E++R EEE+RR RE+E R Q EEE+R E +++ L+ RE EE
Sbjct: 446 KEEEERRRAEEEKRRVEREQEYIRR-QLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEH 504
Query: 230 RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM 289
R+ E + +L QQ+Q + +L Q++ Q P E+ + + + + +
Sbjct: 505 RQAERLQRQL-QQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPA 563
Query: 290 QQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSV-NGQAKTHTDSSEKE 348
+ +V + +K S T + VPS S NG +++ + ++
Sbjct: 564 DRAREV-----EDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRP 618
Query: 349 LEPE 352
EP+
Sbjct: 619 AEPQ 622
Score = 36.6 bits (83), Expect = 0.058
Identities = 35/149 (23%), Positives = 72/149 (48%), Gaps = 21/149 (14%)
Query: 182 EKEEQEKKRKEEEE------------RRRREEEERERLQKEEEKRRRE--EEERLRREEE 227
E+EE+E +E E RR ++E ++ E RR++ +E++LR +EE
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEE 386
Query: 228 ERRRIEEERL-RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQ------QQILIRQL 280
+R++ ER R+EQQK+Q Q + + ++ EQ +++ R+
Sbjct: 387 YKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446
Query: 281 QEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
+E+ ++ ++ +V+ Q+ Q ++E
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEE 475
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 75.5 bits (184), Expect = 1e-13
Identities = 66/216 (30%), Positives = 108/216 (50%), Gaps = 36/216 (16%)
Query: 180 KIEKEEQEKKRKEEEERR----RREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
+IE+++++++R EE++RR RR++E +R +++EEKRR EE ER R+EEEERRR EEE
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ--LQEQHYQQYMQQLY 293
+ R+E++++ I +Q +Q QQQ+L Q L H + + Q
Sbjct: 458 KRRVEREQEYIR-----------RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQ 506
Query: 294 QVQLAQQQA------ALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEK 347
Q QQ+ A + + A + + T N S Q+K + +
Sbjct: 507 QPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKT---NHSSPEAQSK----QTGR 559
Query: 348 ELEP--EAAEEALENGPKESL-PVIAAPSMWTRPQI 380
LEP + E+ NG ES+ P + P+ PQ+
Sbjct: 560 VLEPPVPSRSESFSNGNSESVHPALQRPA---EPQV 592
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/123 (35%), Positives = 79/123 (64%), Gaps = 12/123 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+E++E KR+ ER++R E+++E+ ++ EE++RRE E R ++E E+RRR +EE+ RLE+
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEE- 440
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILI-RQLQEQHYQQYMQQLYQVQLAQQQ 301
L + + ++ A++ E++Q I RQL+E+ Q++++ L Q QL Q+Q
Sbjct: 441 -------LERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE--QRHLEVLQQ-QLLQEQ 490
Query: 302 AAL 304
A L
Sbjct: 491 AML 493
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/127 (24%), Positives = 63/127 (49%), Gaps = 3/127 (2%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
K+ ++ RK+ E+ E E ++EEE +E E + + LRL+Q+
Sbjct: 303 KDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE 362
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
++ AL Q +Q QQ Q+ Y++Q + RQ + + ++ ++L + Q +++A
Sbjct: 363 NKERSEALRRQQLLQEQQLREQE---EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 303 ALQKQQE 309
Q+++E
Sbjct: 420 RRQQERE 426
Score = 36.6 bits (83), Expect = 0.058
Identities = 35/149 (23%), Positives = 72/149 (48%), Gaps = 21/149 (14%)
Query: 182 EKEEQEKKRKEEEE------------RRRREEEERERLQKEEEKRRRE--EEERLRREEE 227
E+EE+E +E E RR ++E ++ E RR++ +E++LR +EE
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEE 386
Query: 228 ERRRIEEERL-RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQ------QQILIRQL 280
+R++ ER R+EQQK+Q Q + + ++ EQ +++ R+
Sbjct: 387 YKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446
Query: 281 QEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
+E+ ++ ++ +V+ Q+ Q ++E
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEE 475
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 75.1 bits (183), Expect = 1e-13
Identities = 41/115 (35%), Positives = 72/115 (62%), Gaps = 9/115 (7%)
Query: 180 KIEKEEQEKKRKEEEERR----RREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
+IE+++++++R EE++RR RR++E +R +++EEKRR EE ER R+EEEERRR EEE
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ 290
+ R+E++++ I L + Q++ ++Q +L+ + H Q Q
Sbjct: 458 KRRVEREQEYIRRQLEEE-----QRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/123 (35%), Positives = 79/123 (64%), Gaps = 12/123 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+E++E KR+ ER++R E+++E+ ++ EE++RRE E R ++E E+RRR +EE+ RLE+
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEE- 440
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILI-RQLQEQHYQQYMQQLYQVQLAQQQ 301
L + + ++ A++ E++Q I RQL+E+ Q++++ L Q QL Q+Q
Sbjct: 441 -------LERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE--QRHLEVLQQ-QLLQEQ 490
Query: 302 AAL 304
A L
Sbjct: 491 AML 493
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/127 (24%), Positives = 63/127 (49%), Gaps = 3/127 (2%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
K+ ++ RK+ E+ E E ++EEE +E E + + LRL+Q+
Sbjct: 303 KDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE 362
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
++ AL Q +Q QQ Q+ Y++Q + RQ + + ++ ++L + Q +++A
Sbjct: 363 NKERSEALRRQQLLQEQQLREQE---EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 303 ALQKQQE 309
Q+++E
Sbjct: 420 RRQQERE 426
Score = 36.6 bits (83), Expect = 0.058
Identities = 35/149 (23%), Positives = 72/149 (48%), Gaps = 21/149 (14%)
Query: 182 EKEEQEKKRKEEEE------------RRRREEEERERLQKEEEKRRRE--EEERLRREEE 227
E+EE+E +E E RR ++E ++ E RR++ +E++LR +EE
Sbjct: 327 EEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEE 386
Query: 228 ERRRIEEERL-RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQ------QQILIRQL 280
+R++ ER R+EQQK+Q Q + + ++ EQ +++ R+
Sbjct: 387 YKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446
Query: 281 QEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
+E+ ++ ++ +V+ Q+ Q ++E
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEE 475
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/118 (36%), Positives = 72/118 (61%), Gaps = 10/118 (8%)
Query: 182 EKEEQEKKRKEEE----ERRRREEEERERLQKEEEKRRREEEER---LRREEEERRRIEE 234
++EE+E++++EE E RRREEEER +K+EE R++EEE R EEE +RR+EE
Sbjct: 801 QREEEERQQQEEALRRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEE 857
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
RLR+E++ ++ + + + ++ +QQQ +R+LQ+Q QQ + Q+
Sbjct: 858 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 915
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/130 (32%), Positives = 79/130 (60%), Gaps = 15/130 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K + + E++R+E E R +REEEER+R +EE RR++EE R++EEER+R EEE L
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKR---QEELRRQQEEILRRQQEEERKRREEEELAR 781
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+Q++ + + A++ Q+ ++ +QQ+ +R+L+E+ ++ ++ +
Sbjct: 782 RKQEEALRRQREQEIALRRQREEEER-----QQQEEALRRLEERRREEEERR-------K 829
Query: 300 QQAALQKQQE 309
Q+ L+KQ+E
Sbjct: 830 QEELLRKQEE 839
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 48/224 (21%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE-------EERLR------ 223
A + ++EE+E+KR +EE RR++EE R Q+EE KRR EE EE LR
Sbjct: 738 AEMRAKREEEERKR--QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 795
Query: 224 ------REEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ--- 274
REEEER++ EE RLE+++++ + ++ Q+ A ++ E+ Q
Sbjct: 796 IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRL 855
Query: 275 -----------ILIRQLQEQHYQQYMQQLYQVQL----AQQQAAL----QKQQEVVVAGS 315
+R +E+ ++ ++ Q +L QQQ AL Q+QQ+ +A
Sbjct: 856 EENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 915
Query: 316 SLPTSSKVNATVPSNMMSVNGQAK---THTDSSEKELEPEAAEE 356
LP+SS SN + QA E+E E + EE
Sbjct: 916 KLPSSSTWGQ--QSNTTACQSQATLSLAEIQKLEEERERQLREE 957
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/133 (31%), Positives = 77/133 (57%), Gaps = 17/133 (12%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A ++++ E+ K K E+ERR E R ++EEE+R+R+EE R ++EE RR+ EEER
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEM----RAKREEEERKRQEELRRQQEEILRRQQEEER 771
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
R E+++ +A + A++ Q+ EQ+ L RQ +E+ QQ + L +++
Sbjct: 772 KRREEEE---LARRKQEEALRRQR----------EQEIALRRQREEEERQQQEEALRRLE 818
Query: 297 LAQQQAALQKQQE 309
+++ +++QE
Sbjct: 819 ERRREEEERRKQE 831
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKE------EEKRRREEEERLRREEEERRRIEEE 235
++EE K +EEEE +RR EE R R+++E EE+ R+ +E ++R++E R+ +++
Sbjct: 837 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 896
Query: 236 -----RLRLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
RL+ +QQ+QQ+ M +S T Q A Q + I++L+E+ +Q
Sbjct: 897 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE--IQKLEEERERQL 954
Query: 289 MQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKE 348
++ + Q +A Q+QQ+ S SK + T S ++ + + +++
Sbjct: 955 REEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS-LLEIQQEEARQMQKQQQQ 1013
Query: 349 LEPEAAEEALENGPKESLPVIAAPSMW 375
+ N +L S+W
Sbjct: 1014 QQQHQQPNRARNNTHSNLHTSIGNSVW 1040
Score = 38.1 bits (87), Expect = 0.020
Identities = 20/88 (22%), Positives = 53/88 (60%), Gaps = 13/88 (14%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE-------------EEERLRREE 226
+I+K E+E++R+ EE+RR++ E + LQ+++++++++ + L ++
Sbjct: 942 EIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1001
Query: 227 EERRRIEEERLRLEQQKQQIMAALNSQT 254
EE R++++++ + +Q +Q A N+ +
Sbjct: 1002 EEARQMQKQQQQQQQHQQPNRARNNTHS 1029
Score = 35.0 bits (79), Expect = 0.17
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 271 EQQQILIRQLQEQHYQQYM-QQLYQVQLAQQQAAL---QKQQEVVVAGSSLPTSSKVNAT 326
+Q+ + Q+Q YQQ++ QQ Y LAQQQ A Q+QQ++ + T K+ +
Sbjct: 607 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT-LKMRIS 665
Query: 327 VPSNMMSVNGQAKTHTDSSEKELEPEAAEEAL-ENGPKESLPV 368
+ + SV S EL+P A++ + E G LP+
Sbjct: 666 DQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPL 708
Score = 30.0 bits (66), Expect = 5.4
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 13/96 (13%)
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ----LQEQHYQQ 287
+++ERL +QQ + AL +Q+QQ+ QQ + Q+L +Q L Q QQ
Sbjct: 599 LDQERLT----RQQELTALYQMQHLQYQQFLIQQ-----QYAQVLAQQQKAALSSQQQQQ 649
Query: 288 YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKV 323
L Q Q + + + Q V S+P + +
Sbjct: 650 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSI 685
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/118 (36%), Positives = 72/118 (61%), Gaps = 10/118 (8%)
Query: 182 EKEEQEKKRKEEE----ERRRREEEERERLQKEEEKRRREEEER---LRREEEERRRIEE 234
++EE+E++++EE E RRREEEER +K+EE R++EEE R EEE +RR+EE
Sbjct: 828 QREEEERQQQEEALRRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEE 884
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
RLR+E++ ++ + + + ++ +QQQ +R+LQ+Q QQ + Q+
Sbjct: 885 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 942
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/130 (32%), Positives = 79/130 (60%), Gaps = 15/130 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K + + E++R+E E R +REEEER+R +EE RR++EE R++EEER+R EEE L
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKR---QEELRRQQEEILRRQQEEERKRREEEELAR 808
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+Q++ + + A++ Q+ ++ +QQ+ +R+L+E+ ++ ++ +
Sbjct: 809 RKQEEALRRQREQEIALRRQREEEER-----QQQEEALRRLEERRREEEERR-------K 856
Query: 300 QQAALQKQQE 309
Q+ L+KQ+E
Sbjct: 857 QEELLRKQEE 866
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 48/224 (21%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE-------EERLR------ 223
A + ++EE+E+KR +EE RR++EE R Q+EE KRR EE EE LR
Sbjct: 765 AEMRAKREEEERKR--QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 822
Query: 224 ------REEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ--- 274
REEEER++ EE RLE+++++ + ++ Q+ A ++ E+ Q
Sbjct: 823 IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRL 882
Query: 275 -----------ILIRQLQEQHYQQYMQQLYQVQL----AQQQAAL----QKQQEVVVAGS 315
+R +E+ ++ ++ Q +L QQQ AL Q+QQ+ +A
Sbjct: 883 EENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 942
Query: 316 SLPTSSKVNATVPSNMMSVNGQAK---THTDSSEKELEPEAAEE 356
LP+SS SN + QA E+E E + EE
Sbjct: 943 KLPSSSTWGQ--QSNTTACQSQATLSLAEIQKLEEERERQLREE 984
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/133 (31%), Positives = 77/133 (57%), Gaps = 17/133 (12%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A ++++ E+ K K E+ERR E R ++EEE+R+R+EE R ++EE RR+ EEER
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEM----RAKREEEERKRQEELRRQQEEILRRQQEEER 798
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
R E+++ +A + A++ Q+ EQ+ L RQ +E+ QQ + L +++
Sbjct: 799 KRREEEE---LARRKQEEALRRQR----------EQEIALRRQREEEERQQQEEALRRLE 845
Query: 297 LAQQQAALQKQQE 309
+++ +++QE
Sbjct: 846 ERRREEEERRKQE 858
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKE------EEKRRREEEERLRREEEERRRIEEE 235
++EE K +EEEE +RR EE R R+++E EE+ R+ +E ++R++E R+ +++
Sbjct: 864 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 923
Query: 236 -----RLRLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
RL+ +QQ+QQ+ M +S T Q A Q + I++L+E+ +Q
Sbjct: 924 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE--IQKLEEERERQL 981
Query: 289 MQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKE 348
++ + Q +A Q+QQ+ S SK + T S ++ + + +++
Sbjct: 982 REEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS-LLEIQQEEARQMQKQQQQ 1040
Query: 349 LEPEAAEEALENGPKESLPVIAAPSMW 375
+ N +L S+W
Sbjct: 1041 QQQHQQPNRARNNTHSNLHTSIGNSVW 1067
Score = 38.1 bits (87), Expect = 0.020
Identities = 20/88 (22%), Positives = 53/88 (60%), Gaps = 13/88 (14%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE-------------EEERLRREE 226
+I+K E+E++R+ EE+RR++ E + LQ+++++++++ + L ++
Sbjct: 969 EIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1028
Query: 227 EERRRIEEERLRLEQQKQQIMAALNSQT 254
EE R++++++ + +Q +Q A N+ +
Sbjct: 1029 EEARQMQKQQQQQQQHQQPNRARNNTHS 1056
Score = 35.0 bits (79), Expect = 0.17
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 271 EQQQILIRQLQEQHYQQYM-QQLYQVQLAQQQAAL---QKQQEVVVAGSSLPTSSKVNAT 326
+Q+ + Q+Q YQQ++ QQ Y LAQQQ A Q+QQ++ + T K+ +
Sbjct: 634 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT-LKMRIS 692
Query: 327 VPSNMMSVNGQAKTHTDSSEKELEPEAAEEAL-ENGPKESLPV 368
+ + SV S EL+P A++ + E G LP+
Sbjct: 693 DQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPL 735
Score = 30.0 bits (66), Expect = 5.4
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 13/96 (13%)
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ----LQEQHYQQ 287
+++ERL +QQ + AL +Q+QQ+ QQ + Q+L +Q L Q QQ
Sbjct: 626 LDQERLT----RQQELTALYQMQHLQYQQFLIQQ-----QYAQVLAQQQKAALSSQQQQQ 676
Query: 288 YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKV 323
L Q Q + + + Q V S+P + +
Sbjct: 677 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSI 712
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/118 (36%), Positives = 72/118 (61%), Gaps = 10/118 (8%)
Query: 182 EKEEQEKKRKEEE----ERRRREEEERERLQKEEEKRRREEEER---LRREEEERRRIEE 234
++EE+E++++EE E RRREEEER +K+EE R++EEE R EEE +RR+EE
Sbjct: 807 QREEEERQQQEEALRRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
RLR+E++ ++ + + + ++ +QQQ +R+LQ+Q QQ + Q+
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 921
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/130 (32%), Positives = 79/130 (60%), Gaps = 15/130 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K + + E++R+E E R +REEEER+R +EE RR++EE R++EEER+R EEE L
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKR---QEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+Q++ + + A++ Q+ ++ +QQ+ +R+L+E+ ++ ++ +
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEER-----QQQEEALRRLEERRREEEERR-------K 835
Query: 300 QQAALQKQQE 309
Q+ L+KQ+E
Sbjct: 836 QEELLRKQEE 845
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 48/224 (21%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE-------EERLR------ 223
A + ++EE+E+KR +EE RR++EE R Q+EE KRR EE EE LR
Sbjct: 744 AEMRAKREEEERKR--QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 801
Query: 224 ------REEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ--- 274
REEEER++ EE RLE+++++ + ++ Q+ A ++ E+ Q
Sbjct: 802 IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRL 861
Query: 275 -----------ILIRQLQEQHYQQYMQQLYQVQL----AQQQAAL----QKQQEVVVAGS 315
+R +E+ ++ ++ Q +L QQQ AL Q+QQ+ +A
Sbjct: 862 EENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 921
Query: 316 SLPTSSKVNATVPSNMMSVNGQAK---THTDSSEKELEPEAAEE 356
LP+SS SN + QA E+E E + EE
Sbjct: 922 KLPSSSTWGQ--QSNTTACQSQATLSLAEIQKLEEERERQLREE 963
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/133 (31%), Positives = 77/133 (57%), Gaps = 17/133 (12%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A ++++ E+ K K E+ERR E R ++EEE+R+R+EE R ++EE RR+ EEER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEM----RAKREEEERKRQEELRRQQEEILRRQQEEER 777
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
R E+++ +A + A++ Q+ EQ+ L RQ +E+ QQ + L +++
Sbjct: 778 KRREEEE---LARRKQEEALRRQR----------EQEIALRRQREEEERQQQEEALRRLE 824
Query: 297 LAQQQAALQKQQE 309
+++ +++QE
Sbjct: 825 ERRREEEERRKQE 837
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKE------EEKRRREEEERLRREEEERRRIEEE 235
++EE K +EEEE +RR EE R R+++E EE+ R+ +E ++R++E R+ +++
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 236 -----RLRLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
RL+ +QQ+QQ+ M +S T Q A Q + I++L+E+ +Q
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE--IQKLEEERERQL 960
Query: 289 MQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKE 348
++ + Q +A Q+QQ+ S SK + T S ++ + + +++
Sbjct: 961 REEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS-LLEIQQEEARQMQKQQQQ 1019
Query: 349 LEPEAAEEALENGPKESLPVIAAPSMW 375
+ N +L S+W
Sbjct: 1020 QQQHQQPNRARNNTHSNLHTSIGNSVW 1046
Score = 38.1 bits (87), Expect = 0.020
Identities = 20/88 (22%), Positives = 53/88 (60%), Gaps = 13/88 (14%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE-------------EEERLRREE 226
+I+K E+E++R+ EE+RR++ E + LQ+++++++++ + L ++
Sbjct: 948 EIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1007
Query: 227 EERRRIEEERLRLEQQKQQIMAALNSQT 254
EE R++++++ + +Q +Q A N+ +
Sbjct: 1008 EEARQMQKQQQQQQQHQQPNRARNNTHS 1035
Score = 35.0 bits (79), Expect = 0.17
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 271 EQQQILIRQLQEQHYQQYM-QQLYQVQLAQQQAAL---QKQQEVVVAGSSLPTSSKVNAT 326
+Q+ + Q+Q YQQ++ QQ Y LAQQQ A Q+QQ++ + T K+ +
Sbjct: 613 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT-LKMRIS 671
Query: 327 VPSNMMSVNGQAKTHTDSSEKELEPEAAEEAL-ENGPKESLPV 368
+ + SV S EL+P A++ + E G LP+
Sbjct: 672 DQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPL 714
Score = 30.0 bits (66), Expect = 5.4
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 13/96 (13%)
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ----LQEQHYQQ 287
+++ERL +QQ + AL +Q+QQ+ QQ + Q+L +Q L Q QQ
Sbjct: 605 LDQERLT----RQQELTALYQMQHLQYQQFLIQQ-----QYAQVLAQQQKAALSSQQQQQ 655
Query: 288 YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKV 323
L Q Q + + + Q V S+P + +
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSI 691
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/118 (36%), Positives = 72/118 (61%), Gaps = 10/118 (8%)
Query: 182 EKEEQEKKRKEEE----ERRRREEEERERLQKEEEKRRREEEER---LRREEEERRRIEE 234
++EE+E++++EE E RRREEEER +K+EE R++EEE R EEE +RR+EE
Sbjct: 807 QREEEERQQQEEALRRLEERRREEEER---RKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
RLR+E++ ++ + + + ++ +QQQ +R+LQ+Q QQ + Q+
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 921
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/130 (32%), Positives = 79/130 (60%), Gaps = 15/130 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K + + E++R+E E R +REEEER+R +EE RR++EE R++EEER+R EEE L
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKR---QEELRRQQEEILRRQQEEERKRREEEELAR 787
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+Q++ + + A++ Q+ ++ +QQ+ +R+L+E+ ++ ++ +
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEER-----QQQEEALRRLEERRREEEERR-------K 835
Query: 300 QQAALQKQQE 309
Q+ L+KQ+E
Sbjct: 836 QEELLRKQEE 845
Score = 63.2 bits (152), Expect = 6e-10
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 48/224 (21%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE-------EERLR------ 223
A + ++EE+E+KR +EE RR++EE R Q+EE KRR EE EE LR
Sbjct: 744 AEMRAKREEEERKR--QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 801
Query: 224 ------REEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ--- 274
REEEER++ EE RLE+++++ + ++ Q+ A ++ E+ Q
Sbjct: 802 IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRL 861
Query: 275 -----------ILIRQLQEQHYQQYMQQLYQVQL----AQQQAAL----QKQQEVVVAGS 315
+R +E+ ++ ++ Q +L QQQ AL Q+QQ+ +A
Sbjct: 862 EENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQM 921
Query: 316 SLPTSSKVNATVPSNMMSVNGQAK---THTDSSEKELEPEAAEE 356
LP+SS SN + QA E+E E + EE
Sbjct: 922 KLPSSSTWGQ--QSNTTACQSQATLSLAEIQKLEEERERQLREE 963
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/133 (31%), Positives = 77/133 (57%), Gaps = 17/133 (12%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A ++++ E+ K K E+ERR E R ++EEE+R+R+EE R ++EE RR+ EEER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEM----RAKREEEERKRQEELRRQQEEILRRQQEEER 777
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
R E+++ +A + A++ Q+ EQ+ L RQ +E+ QQ + L +++
Sbjct: 778 KRREEEE---LARRKQEEALRRQR----------EQEIALRRQREEEERQQQEEALRRLE 824
Query: 297 LAQQQAALQKQQE 309
+++ +++QE
Sbjct: 825 ERRREEEERRKQE 837
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKE------EEKRRREEEERLRREEEERRRIEEE 235
++EE K +EEEE +RR EE R R+++E EE+ R+ +E ++R++E R+ +++
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 236 -----RLRLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
RL+ +QQ+QQ+ M +S T Q A Q + I++L+E+ +Q
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE--IQKLEEERERQL 960
Query: 289 MQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKE 348
++ + Q +A Q+QQ+ S SK + T S ++ + + +++
Sbjct: 961 REEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS-LLEIQQEEARQMQKQQQQ 1019
Query: 349 LEPEAAEEALENGPKESLPVIAAPSMW 375
+ N +L S+W
Sbjct: 1020 QQQHQQPNRARNNTHSNLHTSIGNSVW 1046
Score = 38.1 bits (87), Expect = 0.020
Identities = 20/88 (22%), Positives = 53/88 (60%), Gaps = 13/88 (14%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE-------------EEERLRREE 226
+I+K E+E++R+ EE+RR++ E + LQ+++++++++ + L ++
Sbjct: 948 EIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1007
Query: 227 EERRRIEEERLRLEQQKQQIMAALNSQT 254
EE R++++++ + +Q +Q A N+ +
Sbjct: 1008 EEARQMQKQQQQQQQHQQPNRARNNTHS 1035
Score = 35.0 bits (79), Expect = 0.17
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 271 EQQQILIRQLQEQHYQQYM-QQLYQVQLAQQQAAL---QKQQEVVVAGSSLPTSSKVNAT 326
+Q+ + Q+Q YQQ++ QQ Y LAQQQ A Q+QQ++ + T K+ +
Sbjct: 613 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQT-LKMRIS 671
Query: 327 VPSNMMSVNGQAKTHTDSSEKELEPEAAEEAL-ENGPKESLPV 368
+ + SV S EL+P A++ + E G LP+
Sbjct: 672 DQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPL 714
Score = 30.0 bits (66), Expect = 5.4
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 13/96 (13%)
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ----LQEQHYQQ 287
+++ERL +QQ + AL +Q+QQ+ QQ + Q+L +Q L Q QQ
Sbjct: 605 LDQERLT----RQQELTALYQMQHLQYQQFLIQQ-----QYAQVLAQQQKAALSSQQQQQ 655
Query: 288 YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKV 323
L Q Q + + + Q V S+P + +
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSI 691
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.4 bits (176), Expect = 1e-12
Identities = 45/129 (34%), Positives = 84/129 (65%), Gaps = 12/129 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERE-RLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
E+ EQ+++R+E++ERR ++EE RE +L++E+E+RR E++LRRE+EE RR E++LR E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERR---EQQLRREQEEERR--EQQLRRE 367
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Q++++ L + ++ +Q + EQQ +QL+ + + QQL + Q ++
Sbjct: 368 QEEERREQQLRREQQLRREQQLRR------EQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 301 QAALQKQQE 309
+ L+++QE
Sbjct: 422 EQQLRREQE 430
Score = 70.1 bits (170), Expect = 5e-12
Identities = 37/130 (28%), Positives = 79/130 (60%), Gaps = 3/130 (2%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ ++E+++K +EEE++ RR+E ER+ LQ+E++ RR+E E + R EE+ R+ E+E+LR
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+++ ++I+ + + QQ Q+ + +++ L QE+ QQ Q + +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL---RQEREEQQLRSQESDRKFRE 1799
Query: 300 QQAALQKQQE 309
++ Q+++E
Sbjct: 1800 EEQLRQEREE 1809
Score = 69.3 bits (168), Expect = 8e-12
Identities = 43/136 (31%), Positives = 87/136 (63%), Gaps = 11/136 (8%)
Query: 182 EKEEQEKKRKEEEERRRREEEERER-LQKEEEKRRREEEER---LRREEEERRRIEEERL 237
E E E++R++++ +R +EEE RER L+ EEE+RR ++E R LRRE+EERR E+RL
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR---EQRL 519
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ----QLY 293
+ +++++++ L S+ ++ +Q ++ E+++ L ++ +EQ ++ + QL
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 294 QVQLAQQQAALQKQQE 309
+ + ++Q L+++QE
Sbjct: 580 KREEERRQQRLKREQE 595
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/133 (30%), Positives = 85/133 (63%), Gaps = 9/133 (6%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER-----L 237
+EE+E+ ++EE E+RRR+E+ER+ +EEE+ ++EEE+ LR E E+RRR E ER
Sbjct: 907 QEEEEELQREEREKRRRQEQERQ--YREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQV-- 295
+L+Q+++Q++ + Q ++ ++ ++++ L+R+ +E+ +Q ++ Y+
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 296 QLAQQQAALQKQQ 308
+L Q++ L +++
Sbjct: 1025 ELQQEEEQLLREE 1037
Score = 68.9 bits (167), Expect = 1e-11
Identities = 47/151 (31%), Positives = 87/151 (57%), Gaps = 21/151 (13%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQK-------EEEKRRREEEERLRREEEERRRI 232
++ ++E E+K +EEE+ R+ E+E+ R Q+ EE+ R EE++LRR+E +R+
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774
Query: 233 EEERLRLEQQKQQIMAALNS---------QTAVQFQQYAAQQYPGNY--EQQQILIRQLQ 281
EEE+LR E+++QQ+ + + + + QQ QQ G Y E++Q+ + + Q
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE-Q 1833
Query: 282 EQHYQQYMQQLYQV--QLAQQQAALQKQQEV 310
EQ +Q + Y+ Q A Q+ + +++QE+
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Score = 68.6 bits (166), Expect = 1e-11
Identities = 47/134 (35%), Positives = 81/134 (60%), Gaps = 16/134 (11%)
Query: 182 EKEEQEKKRKEEEERR-----RREEEERE-RLQKEEEKRRREEEERLRREEEERRRIE-- 233
E+ EQ+++R+++EERR R +EE RE +L++E+E+ RRE++ LRRE+EE RR +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ--LRREQEEERREQQL 377
Query: 234 --EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQ----QQILIRQLQEQHYQQ 287
E++LR EQQ ++ Q + QQ +Q +Q QQ+ Q +E+H Q+
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 288 YMQQLYQVQLAQQQ 301
+ Q+ + +L ++Q
Sbjct: 438 HEQERREQRLKREQ 451
Score = 68.2 bits (165), Expect = 2e-11
Identities = 47/140 (33%), Positives = 81/140 (57%), Gaps = 8/140 (5%)
Query: 175 YVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEE 234
Y ++++EE++ R+E E+RRR +ERER +EEE+ ++EEE+ LR E E+RRR E
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRR---QERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 235 ERLRLEQQ--KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ---ILIRQLQEQHYQQYM 289
ER E++ +Q+ L + + +Q +QY E QQ L+R+ QE+ Q+
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 290 QQLYQVQLAQQQAALQKQQE 309
+Q + + Q+Q Q+ ++
Sbjct: 1197 RQYREEEELQRQKRKQRYRD 1216
Score = 67.8 bits (164), Expect = 2e-11
Identities = 43/114 (37%), Positives = 68/114 (59%), Gaps = 23/114 (20%)
Query: 183 KEEQEKKRKEEEERRRREEEERER-----LQKEEEKRRREEEERLRREEEERRRIEEERL 237
+EE+EK+R++E ER+ REEEE ++ L++E EKRRR+E ER REEEE ++ EE+ L
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
R EQ+K++ Q+ Y +++ L RQ ++Q Y+ Q+
Sbjct: 1185 REEQEKRR------------------QERERQYREEEELQRQKRKQRYRDEDQR 1220
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 41/196 (20%)
Query: 141 DRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEER---- 196
+RR W L + + + L R + E+ EQ KR+EEEER
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRR-----------EQEERREQRLKRQEEEERLQQR 531
Query: 197 -------RRREEEERERLQKEEEKRRREEE---ERLRREEEERR----RIEEERLRLE-- 240
RR +EE RE+L K EE++R E+E +RL+RE+EERR + EEER +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 241 -QQKQQIMAALNSQTAVQFQQYAAQQY------PGNYEQQQILIRQLQEQHYQQYMQQLY 293
+Q++++ L + + +Q ++ P +QQ+L + QE+ Q QQL
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ---QQLR 648
Query: 294 QVQLAQQQAALQKQQE 309
+ Q +++ L++++E
Sbjct: 649 REQQERREQRLKREEE 664
Score = 67.0 bits (162), Expect = 4e-11
Identities = 40/137 (29%), Positives = 86/137 (62%), Gaps = 6/137 (4%)
Query: 180 KIEKEEQEKKRK--EEEERRR---REEEERERLQKEEEKRRREEEERLRREEEERRRIEE 234
K+++EE +++R+ EEEE+ R R+E RER ++E++++R E++LRR++EE RR ++
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQL-QEQHYQQYMQQLY 293
E R +Q++++ Q + Q+ +Q ++++ +QL +EQ ++ QQL
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 294 QVQLAQQQAALQKQQEV 310
+ Q +++ L+++Q++
Sbjct: 379 REQQLRREQQLRREQQL 395
Score = 67.0 bits (162), Expect = 4e-11
Identities = 41/131 (31%), Positives = 79/131 (60%), Gaps = 6/131 (4%)
Query: 184 EEQEKKRKEEEERRRREEEERER-----LQKEEEKRRREEEERLRREEEERRRIEEERLR 238
EE EK+R++E E++ REEEE ++ L++E EKRRR+E ER R+++E ++ EE+ LR
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 239 LEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLA 298
E++K+++ + Q +Q G E++ ++L+ Q+ ++ Q + QL
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGE-ERETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 299 QQQAALQKQQE 309
+++ +++QE
Sbjct: 1095 REEPEKRRRQE 1105
Score = 66.2 bits (160), Expect = 7e-11
Identities = 41/132 (31%), Positives = 79/132 (59%), Gaps = 10/132 (7%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQK---EEEKRRREEEE----RLRREEEERRRIEEE 235
++E+EK ++EE +R+R +EE E+L+K +E +R R+EEE RLRRE++ RR+ EEE
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQV 295
R ++++++ Q + QQ +Q ++Q L R+ +E+ +Q +++ +
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQ---EERREQQLRREQEEERREQQLRREQEE 370
Query: 296 QLAQQQAALQKQ 307
+ +QQ ++Q
Sbjct: 371 ERREQQLRREQQ 382
Score = 63.5 bits (153), Expect = 4e-10
Identities = 45/141 (31%), Positives = 82/141 (58%), Gaps = 17/141 (12%)
Query: 183 KEEQEKKRKEE----EERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL- 237
+EE+E +++EE EER R +E ER ++EE+ ++EEE+ LR E E+RRR E ER
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 238 ----RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQ---ILIRQLQEQHYQQYMQ 290
L+Q+++Q+ L + + +Q +QY E QQ L+R+ E+ +Q ++
Sbjct: 1111 REEEELQQEEEQL---LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 291 QLY--QVQLAQQQAALQKQQE 309
+ Y + +L Q++ L ++++
Sbjct: 1168 RQYREEEELQQEEEQLLREEQ 1188
Score = 63.2 bits (152), Expect = 6e-10
Identities = 41/134 (30%), Positives = 79/134 (58%), Gaps = 8/134 (5%)
Query: 183 KEEQEKKRKEEEERRRR-----EEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL 237
+EE+EK+R++E ER+ R +++E + L +E EKRRR+E E+ REEEE ++ EE+ L
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 238 RLEQQKQQIMA-ALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
R E++K++ + + QQ Q E++++ R+ Q + ++ Q+ + Q
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE--EEQ 1062
Query: 297 LAQQQAALQKQQEV 310
L ++ +++QE+
Sbjct: 1063 LLGEERETRRRQEL 1076
Score = 63.2 bits (152), Expect = 6e-10
Identities = 40/139 (28%), Positives = 85/139 (61%), Gaps = 11/139 (7%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQ------KEEEKRRREEEERLRREEEE--RRR 231
++ ++E+++K +EEE+ R+ EE++ R Q +EEE+ R+E EE+ R ++ + R
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
EEE+L+LE+Q+Q++ + Q + +Q+A Q+ EQ+ L ++ +++ Q+ ++
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREEQE--LWQEEEQKRRQERERK 1879
Query: 292 LYQVQLAQQQAALQKQQEV 310
L + + +QQ Q+ ++V
Sbjct: 1880 LREEHIRRQQKEEQRHRQV 1898
Score = 62.8 bits (151), Expect = 8e-10
Identities = 39/135 (28%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL-- 237
K ++ +QE+++ EER +R +ERER +EEE+ ++EEE+ L E E RRR E ER
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 238 ---RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
L+Q+++Q++ + Q ++ ++ ++++ L+R+ +E+ +Q +++ Y+
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 295 VQLAQQQAALQKQQE 309
+ QQ Q +E
Sbjct: 1142 EEEEVQQEEEQLLRE 1156
Score = 62.8 bits (151), Expect = 8e-10
Identities = 36/136 (26%), Positives = 79/136 (58%), Gaps = 10/136 (7%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL-- 237
++ +EQ +K EEE+R RR+E ER+ L++E++ R +E E++LR++ + + R EE++L
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 238 -----RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
+ +++QQ+ + ++ +Q Q+ + +++ L LQE+ QQ +Q
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL---LQEREEQQLHRQE 1482
Query: 293 YQVQLAQQQAALQKQQ 308
+ +++ L++Q+
Sbjct: 1483 RDRKFLEEEQQLRRQE 1498
Score = 62.4 bits (150), Expect = 1e-09
Identities = 46/169 (27%), Positives = 88/169 (52%), Gaps = 9/169 (5%)
Query: 142 RRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQ---EKKRKEEEERRR 198
+R+EW +E+ E +L + H + ++ + E +K +EE++++R
Sbjct: 176 QRQEW-----QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 199 REEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQF 258
RE ++R Q+EEEK R+ E LR+EEE+ + E +R R Q++++ + L Q +
Sbjct: 231 RERQDRV-FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 259 QQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQ 307
+Q QQ +QQ+ +Q +E+ QQ ++ Q + QQ+ ++Q
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Score = 62.4 bits (150), Expect = 1e-09
Identities = 42/132 (31%), Positives = 77/132 (58%), Gaps = 12/132 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEER-----ERLQKEEEKRRREEEERLRREEEERRRIEEERL 237
++E+E+ +EE E+RRR+E ER + LQ+EEE+ REE E+ R +E ER+ EEE L
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
+ E+++ L + + +Q +QY E QQ + L+E+ ++ Q+ + +
Sbjct: 1057 QQEEEQ-----LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE--RERQ 1109
Query: 298 AQQQAALQKQQE 309
+++ LQ+++E
Sbjct: 1110 CREEEELQQEEE 1121
Score = 62.0 bits (149), Expect = 1e-09
Identities = 40/128 (31%), Positives = 79/128 (61%), Gaps = 4/128 (3%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+EE+++ ++E +R+ REEE++ R Q E E++ EEE++LR+E + R EEE+L E++
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQ-ERERKFLEEEQQLRQERHRKFR-EEEQLLQERE 1474
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
+QQ+ + ++ +Q +Q ++Q L Q E+ + + QQL++ Q +Q+
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ--RQRK 1532
Query: 303 ALQKQQEV 310
LQ++Q++
Sbjct: 1533 FLQEEQQL 1540
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/131 (27%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ +E E+K EEE++ R++ +R+ LQ+E++ RR+E ++ RR++ +R+ EEE+LR
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ-RRQDRDRKFREEEQLRQ 1565
Query: 240 EQQKQQI-MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLA 298
E+++QQ+ + + ++ Q+ Q+ + + + +QL+ Q QQ ++Q +
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE---QQLRRQEGQQQLRQERDRKFR 1622
Query: 299 QQQAALQKQQE 309
+ + LQ+++E
Sbjct: 1623 EDEQLLQEREE 1633
Score = 61.6 bits (148), Expect = 2e-09
Identities = 47/139 (33%), Positives = 80/139 (57%), Gaps = 22/139 (15%)
Query: 182 EKEEQEKKRKEEEERR----RREEEERERLQKEEEKRRREEEER----LRREEEERRRIE 233
E+EE+ ++K E+ERR +RE+EER K EE+ R E+ER L+R++EE RR
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR-- 485
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM---Q 290
E L+LE+++++ Q + QQ +Q ++Q L RQ +E+ QQ + Q
Sbjct: 486 ERWLKLEEEERR------EQQERREQQLRREQ---EERREQRLKRQEEEERLQQRLRSEQ 536
Query: 291 QLYQVQLAQQQAALQKQQE 309
QL + Q +++ L++++E
Sbjct: 537 QLRREQEERREQLLKREEE 555
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/152 (29%), Positives = 87/152 (57%), Gaps = 24/152 (15%)
Query: 182 EKEEQEKKRKEEEERRRREEEERE-RLQKEEEKRR-----REEE---ERLRREEEER--- 229
E+EE+ ++ + EE +R E+E RE RL++E+E+RR REEE +RL+RE+EER
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 230 --RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQ----------QILI 277
+R E ERL E++++Q + + + Q +++ +QQ Q L
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 278 RQLQEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
R+ +E+ +Q +++ ++ + +Q+ A ++Q++
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Score = 61.6 bits (148), Expect = 2e-09
Identities = 41/137 (29%), Positives = 83/137 (60%), Gaps = 12/137 (8%)
Query: 182 EKEEQEKKRKEEEERRRREE--EERERLQKEEEKRRREEEERLRREEEERRRIEEE---- 235
E+EE+E++R++ ER + + EE E+LQ+ E ++ +EEE +E++ERRR +E+
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 236 --RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
R +LE+++++ L ++ A+Q Q QQ E+++ L R+ +E+ +Q ++ Y
Sbjct: 873 KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL--LQEEEEELQREEREKRRRQEQERQY 930
Query: 294 --QVQLAQQQAALQKQQ 308
+ QL Q++ L +++
Sbjct: 931 REEEQLQQEEEQLLREE 947
Score = 61.6 bits (148), Expect = 2e-09
Identities = 36/130 (27%), Positives = 77/130 (59%), Gaps = 6/130 (4%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERR-RIEEERLR 238
K +EEQ+ +R+E ++RR++ + + R +EE+ R+ EE++L R+E +R+ R+EE+++R
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFR--EEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 239 LEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLA 298
++Q+++ M + QQ Q+ + + + L LQE+ QQ +Q +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL---LQEREEQQLHRQERDRKFL 1646
Query: 299 QQQAALQKQQ 308
+++ L++Q+
Sbjct: 1647 EEEPQLRRQE 1656
Score = 61.2 bits (147), Expect = 2e-09
Identities = 52/150 (34%), Positives = 84/150 (56%), Gaps = 25/150 (16%)
Query: 182 EKEEQEKKRK-------EEEERRRRE---EEERERLQKEEEKRRRE---EEERLR---RE 225
EK++Q ++R+ EE+E R+RE +E E+LQ+EE +R+RE EEE+LR R+
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 226 EEERRRIEEE----RLRLEQQ--KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ 279
E R R EEE RLR EQQ ++Q Q + QQ +Q EQQ +R+
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ---LRR 341
Query: 280 LQEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
QE+ +Q +++ + + +QQ ++++E
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEE 371
Score = 61.2 bits (147), Expect = 2e-09
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 12/133 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERER-----LQKEEEKRRREEEERLRREEEERRRIEEERL 237
+EE EK+R++E ER+ REEEE ++ L++E+EKRR+E E + R EEE +R+ ++R
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 238 RLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQV 295
R E Q+ + + AV+ + + N + +Q+ QL+++ QQ +Q L
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE-NEQFRQLEDSQLRDRQSQQDLQHL--- 1270
Query: 296 QLAQQQAALQKQQ 308
L +QQ ++Q+
Sbjct: 1271 -LGEQQERDREQE 1282
Score = 61.2 bits (147), Expect = 2e-09
Identities = 51/193 (26%), Positives = 105/193 (54%), Gaps = 17/193 (8%)
Query: 180 KIEKEEQEKKRKEEEERRRREE------EERERLQKEEEKRRRE-EEERLRREEEERRRI 232
K+ ++EQE+K E+E++ RR+E +ER+R +E+E+ +E EE++L R+E +R+ +
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 233 EEE-RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
EEE +LR ++++QQ L +F++ +Q E+QQ L RQ +++ +++ QQ
Sbjct: 1647 EEEPQLRRQEREQQ----LRHDRDRKFRE--EEQLLQEGEEQQ-LRRQERDRKFREEEQQ 1699
Query: 292 LYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP 351
L + + +++ LQ++Q++ + + + Q + E++L P
Sbjct: 1700 LRRQE--RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 352 EAAEEALENGPKE 364
E E+ L ++
Sbjct: 1758 EREEQQLRRQERD 1770
Score = 61.2 bits (147), Expect = 2e-09
Identities = 38/132 (28%), Positives = 82/132 (62%), Gaps = 10/132 (7%)
Query: 181 IEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
+++ E+++ R++E +R+ REEE++ R Q E E++ +EE++LRR+E ER+ EEE+LR E
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHY---QQYMQQLYQVQL 297
+++Q+ + ++ +Q ++ ++Q L RQ +++ + +Q Q+ + QL
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPER------EEQQLRRQERDRKFREEEQLRQEREEQQL 1788
Query: 298 AQQQAALQKQQE 309
Q++ + ++E
Sbjct: 1789 RSQESDRKFREE 1800
Score = 60.8 bits (146), Expect = 3e-09
Identities = 45/141 (31%), Positives = 81/141 (57%), Gaps = 21/141 (14%)
Query: 183 KEEQEKKRKEEEERRRREEEERER------LQKEEEKRRREEEER---LRREEEERRRIE 233
+EE++++R+E ++R +EEEE+E L+KEEEK + EE +R L+ EEE+ R++E
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 234 EERLRLE-----QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
+ LR E QQ+Q++ Q + ++ +Q EQQ + +EQ ++
Sbjct: 283 RQELRRERQEEEQQQQRLRR--EQQLRRKQEEERREQQEERREQQ-----ERREQQEERR 335
Query: 289 MQQLYQVQLAQQQAALQKQQE 309
QQL + Q +++ L+++QE
Sbjct: 336 EQQLRREQEERREQQLRREQE 356
Score = 60.8 bits (146), Expect = 3e-09
Identities = 40/132 (30%), Positives = 79/132 (59%), Gaps = 12/132 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERE-----RLQKEEEKRRREEEERLRREEEERRRIEEERL 237
++E+E+ +EE E+RRR+E ER+ +LQ++EE+ EE E+ RR+E E++ EEE L
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
+ E+++ L + + +Q +QY E QQ + L+E+ ++ +Q+ + +
Sbjct: 997 QQEEEQ-----LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQ 1049
Query: 298 AQQQAALQKQQE 309
+++ LQ+++E
Sbjct: 1050 YREEEELQQEEE 1061
Score = 60.8 bits (146), Expect = 3e-09
Identities = 38/128 (29%), Positives = 76/128 (59%), Gaps = 6/128 (4%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKE-----EEKRRREEEERLRREEEERRRIEE 234
++ ++E+++K +EEE++ RR+E ER+ L++E E R+ EEE+L +E EE++ +
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNY-EQQQILIRQLQEQHYQQYMQQLY 293
ER R +++Q + + Q+ +Q+ + E++Q L RQ +++ + Q QQL
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 294 QVQLAQQQ 301
+ + QQ+
Sbjct: 1542 RQERGQQR 1549
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/133 (27%), Positives = 81/133 (60%), Gaps = 9/133 (6%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL----- 237
++++E+ EE E+RRR +ERE+ +EEE+ ++EEE+ LR E E+RRR E ER
Sbjct: 967 QQKEEQLLGEEPEKRRR--QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY--QV 295
L+Q+++Q++ + +Q ++ ++ ++++ L+ + +E +Q +++ Y +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 296 QLAQQQAALQKQQ 308
+L Q++ L +++
Sbjct: 1085 ELQQEEEQLLREE 1097
Score = 59.7 bits (143), Expect = 6e-09
Identities = 39/127 (30%), Positives = 73/127 (57%), Gaps = 15/127 (11%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+ EQE++R+E++ RR +EEE RE+ + E++ RRE++ LRRE++ RR E++LR EQQ
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQ--LRREQQLRR---EQQLRREQQ 406
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
++ Q + QQ +Q +EQ +H Q+ +Q + + +++
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQ----------KHEQERREQRLKREQEERRD 456
Query: 303 ALQKQQE 309
L++++E
Sbjct: 457 WLKREEE 463
Score = 59.7 bits (143), Expect = 6e-09
Identities = 38/133 (28%), Positives = 76/133 (57%), Gaps = 11/133 (8%)
Query: 183 KEEQEKKRKEE---EERRRREEEERERLQKEEEKRRREEEERLRREEEER-----RRIEE 234
+ EQ+ +R+++ E++ RRE+EE QK E++RR E+RL+RE+EER R E
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---EQRLKREQEERRDWLKREEET 464
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
ER E++KQQ+ + ++ + ++ E+++ +R+ QE+ +Q +++ +
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524
Query: 295 VQLAQQQAALQKQ 307
+ QQ+ ++Q
Sbjct: 525 EERLQQRLRSEQQ 537
Score = 59.3 bits (142), Expect = 8e-09
Identities = 47/165 (28%), Positives = 89/165 (53%), Gaps = 37/165 (22%)
Query: 182 EKEEQEKKR--KEEEERRRREEE-----------------------ERERLQKEEEKRRR 216
+++ QE+K+ +EE E +RR +E ER+R +EEE R +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 217 -------EEEERLRREEEERRRI-EEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPG 268
EEE+RLRR+E ER+ + EE++LR ++++QQ+ + + + QQ + Q+
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 269 NY-EQQQILIRQLQEQHYQQYMQQLYQV---QLAQQQAALQKQQE 309
+ E++Q + RQ +E+ + + QQL Q + +++ LQ+++E
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/184 (22%), Positives = 92/184 (50%), Gaps = 13/184 (7%)
Query: 186 QEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQ 245
+++ R+E++ RR ++ ++L++E++ RR +EEER ++ E+ RR E+RL+ EQ++++
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERR 455
Query: 246 IMAALNSQTAVQFQQYAAQQYPGNYEQQQ-----ILIRQLQEQHYQQYMQQLYQVQLAQQ 300
+T Q+ QQ + E+++ L + + + ++ QQL + Q ++
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 301 QAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALEN 360
+ L++Q+E L + ++ + + EK LE E E+ L+
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEER------REQLLKREEEKRLEQERREQRLKR 569
Query: 361 GPKE 364
+E
Sbjct: 570 EQEE 573
Score = 57.0 bits (136), Expect = 4e-08
Identities = 48/161 (29%), Positives = 82/161 (50%), Gaps = 36/161 (22%)
Query: 183 KEEQEKKRKEE------------EERRRRE--------------------EEERERLQKE 210
+E+QE++R +E EER+RR +EE E LQ+E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 211 E-EKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGN 269
E EKRRR+E+ER REEE+ ++ EE+ LR E++K++ + Q +Q G
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG- 975
Query: 270 YEQQQILIRQLQEQHYQQYMQ-QLYQVQLAQQQAALQKQQE 309
E+ + RQ +E+ Y++ + Q + QL +++ +++QE
Sbjct: 976 -EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Score = 56.6 bits (135), Expect = 5e-08
Identities = 43/143 (30%), Positives = 84/143 (58%), Gaps = 14/143 (9%)
Query: 180 KIEKEEQEKKRK------EEEERRRREEEERERLQKEEEKRRREEEE-----RLRRE-EE 227
++++EE E++R+ EE+E RR+++ RE+ ++ E++ +REEEE RL+RE EE
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Query: 228 ERRRIEEERLRLEQQKQQIMAALNS-QTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQ 286
ERR E EQ +++I + + Q ++ + A Q + ++Q R+ QEQ +
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 287 QYMQQLYQVQLAQQQAALQKQQE 309
+ ++ ++Q +++ A ++QQE
Sbjct: 739 RRRRE-SELQWQEEERAHRQQQE 760
Score = 56.6 bits (135), Expect = 5e-08
Identities = 35/135 (25%), Positives = 74/135 (54%), Gaps = 5/135 (3%)
Query: 179 HKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE-----EEERLRREEEERRRIE 233
H+ +EE++ ++ EE++ R+E +R+ L++E++ RR+E E+ LR +E ER+ +E
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
EE+ QQ+Q+ Q Q + +Q +++ +RQ +E+ ++
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579
Query: 294 QVQLAQQQAALQKQQ 308
+ +L +Q+ Q+Q+
Sbjct: 1580 KFRLEEQKVRRQEQE 1594
Score = 55.5 bits (132), Expect = 1e-07
Identities = 41/128 (32%), Positives = 70/128 (54%), Gaps = 12/128 (9%)
Query: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRR----REEEERLRREEEERRR--------I 232
EQE++R ++ +R EEE+ ER +++E KRR +EE++ LR E EE+RR
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 233 EEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
EEE+L E+++Q + + + + +Q E++Q L RQ +E+ + + QQL
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 293 YQVQLAQQ 300
+ QQ
Sbjct: 1400 RCQEREQQ 1407
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/120 (27%), Positives = 69/120 (57%), Gaps = 7/120 (5%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRR-REEEERLRREEEERRRIEEERLRLE 240
++ Q++ RK EE + R+E E ++L ++E R+ R EE+++RR+E+ER+ +E+E+
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Q+ QQ + + + +Q ++ ++Q L RQ +++ + + QL + + QQ
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQER------EEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Score = 54.3 bits (129), Expect = 3e-07
Identities = 36/142 (25%), Positives = 84/142 (59%), Gaps = 13/142 (9%)
Query: 180 KIEKEEQEKKRKEEEERRRREEE------ERERLQKEEEKRR-REEEERLRREEEERRRI 232
++ ++E+E++ + + +R+ REEE E ++L+++E R+ REEE++LRR+E ER+ +
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 233 -EEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQ-YPGNYEQQQIL----IRQLQEQHYQ 286
EE++LR ++ +++ + + +Q Q+ Y E++Q+ +QL+ Q
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 287 QYMQQLYQVQLAQQQAALQKQQ 308
+ ++ Q++ +++ L+ Q+
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQE 1792
Score = 54.3 bits (129), Expect = 3e-07
Identities = 30/118 (25%), Positives = 68/118 (57%), Gaps = 5/118 (4%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEE---RERLQKEEEKRRREEEERLRREEEERRRIEEER 236
+++ EEQE++ ++E +R+ R EE+ +E+ ++EE++ +EEE++ R+E E R++ EE
Sbjct: 1827 QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE--RKLREEH 1884
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
+R +Q+++Q + + + + + PG ++ + +R Y Q + Y+
Sbjct: 1885 IRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYR 1942
Score = 53.9 bits (128), Expect = 4e-07
Identities = 38/143 (26%), Positives = 78/143 (54%), Gaps = 16/143 (11%)
Query: 176 VASHKIEKEEQEKKRKEEEERRRRE------EEERERLQKEEEKRRREEEERLRREEEE- 228
V S ++E Q +++++EE+RRRRE EEER Q++EE++RR+ + + EE+
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 229 --RRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQ 286
R+R+ EQ+++Q+ A Q +F P E++Q ++ + +
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRF-------LPEEEEKEQRRRQRREREKEL 831
Query: 287 QYMQQLYQVQLAQQQAALQKQQE 309
Q++++ Q+Q ++ LQ++++
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEED 854
Score = 52.8 bits (125), Expect = 8e-07
Identities = 40/158 (25%), Positives = 82/158 (51%), Gaps = 33/158 (20%)
Query: 184 EEQEKKRKEEEERRRREEEERE---RLQKEEEKRRR----------------------EE 218
+E+E +E++ERRR +E+ R+ R Q EEE++RR EE
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 219 EERLRREEEERRRIEE------ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQ 272
EE L+REE E+RR +E E +L+Q+++Q++ + Q ++ ++ ++
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 273 QQILIRQLQEQHYQQYMQQLY--QVQLAQQQAALQKQQ 308
++ L+ + E+ +Q ++ Y + +L Q++ L +++
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Score = 51.6 bits (122), Expect = 2e-06
Identities = 39/168 (23%), Positives = 80/168 (47%), Gaps = 19/168 (11%)
Query: 149 LGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQ 208
LG + D E + R H + +KE + + RK +EE++ EE E+ +
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330
Query: 209 KEEEKRRREEEERLRREEEER--------RRIEEERLRLEQQKQQIMAALNSQTAVQFQQ 260
++E R+ EEE+L +E EE+ R+ EE LR ++Q ++ + + Q+
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE--------EEQR 1382
Query: 261 YAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQ 308
Q+ + +++ +QL+ Q +Q ++Q + +++ L +Q+
Sbjct: 1383 LRRQERERKFLKEE---QQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/131 (27%), Positives = 75/131 (57%), Gaps = 10/131 (7%)
Query: 178 SHKIEKEEQEKKRKEEEERR-----RREEEER--ERLQKEEEKRRREEEERLRREEEERR 230
S + E+ Q++ R+E++ERR R EEEER +RL++E E+ RRE+E L EE+E+
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE--LAEEEQEQA 693
Query: 231 RIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ 290
R E + R+ + + Q+ + +++ + + + Q+ ++Q+ R+ + + Q +
Sbjct: 694 R-ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE 752
Query: 291 QLYQVQLAQQQ 301
+ ++ Q ++Q
Sbjct: 753 RAHRQQQEEEQ 763
Score = 50.8 bits (120), Expect = 3e-06
Identities = 37/128 (28%), Positives = 74/128 (57%), Gaps = 8/128 (6%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+EE++ +R+ ER ++ +EE + LQ+++E+RR +E+ RR+++ R ++EEER R +
Sbjct: 835 EEEEQLQRR---ERAQQLQEEEDGLQEDQERRRSQEQ---RRDQKWRWQLEEERKR-RRH 887
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ-QLYQVQLAQQQ 301
AL Q + Q ++ E+++ RQ QE+ Y++ Q Q + QL +++
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 302 AALQKQQE 309
+++QE
Sbjct: 948 REKRRRQE 955
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/138 (26%), Positives = 74/138 (53%), Gaps = 11/138 (7%)
Query: 182 EKEEQEKKR-------KEEEERRRREEEERERLQK---EEEKRRREEEERLRREEEERRR 231
EK E+ ++R +E+ ER+ R EE ++R Q+ EEE++ + +R RE+E +
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
EEE+L+ ++ QQ+ + Q ++ +Q+ + + + L + + + + Y +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQ-ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 292 LYQVQLAQQQAALQKQQE 309
Q QL ++Q LQ+++E
Sbjct: 894 ALQEQLRKEQQLLQEEEE 911
Score = 48.5 bits (114), Expect = 1e-05
Identities = 36/136 (26%), Positives = 67/136 (49%), Gaps = 10/136 (7%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRRE--------EEERLRREEEERRRIE 233
E +E+E++R EEE+ + + E E EE+ RRRE EE+ ++ E + R+
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
+E E +K++ + + + + ++ EQ + L RQ + Q+ QQ
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ-- 296
Query: 294 QVQLAQQQAALQKQQE 309
Q +L ++Q +KQ+E
Sbjct: 297 QQRLRREQQLRRKQEE 312
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/202 (22%), Positives = 96/202 (47%), Gaps = 34/202 (16%)
Query: 142 RRREWAALGNMSKEDAMVEFVKLLN------RCCHLFSTYVASHKIEKEEQEKKRKEEEE 195
RRR+ +E+ E +LL R L Y ++++EE++ R+E+E+
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 196 RRR---REEEERERLQKEEEKRR-REEEER----------------------LRREEEER 229
RR+ R+ E E LQ+++ K+R R+E++R RE E+
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 230 RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAA--QQYPGNYEQQQILIRQLQEQHYQQ 287
R++E+ +LR Q +Q + L Q +Q QQ ++ +++ L R+ Q++ ++
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 288 YMQQLYQVQLAQQQAALQKQQE 309
+ + QL +++ +++++
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQ 1332
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/140 (25%), Positives = 80/140 (57%), Gaps = 16/140 (11%)
Query: 182 EKEEQEKKRKEEEERRRREEEE-RERLQKEEEKRRREEEERLRR----------EEEERR 230
E++ ++++R E+ +R+RR+EE R+R + +E + RR EEE+L+ +EE+ R
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211
Query: 231 RIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ 290
R E LR + ++++ Q V FQ+ ++ + +++ ++R+ +E+ ++ Q
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRV-FQEEEEKE----WRKRETVLRKEEEKLQEEEPQ 266
Query: 291 QLYQVQLAQQQAALQKQQEV 310
+ ++Q ++Q ++QE+
Sbjct: 267 RQRELQEEEEQLRKLERQEL 286
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 27/154 (17%)
Query: 179 HKIEKEEQEKKRKEEEERRRR------------EEEERERLQKEEEKRRREEEERLRREE 226
H+ E+ EQE +E+E+ R R E E R K + R++E +R R+E+
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 227 EERRR--------IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQ----YPGNYEQQQ 274
EE+RR EEER +QQ+++ Q + + +Q P EQ++
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 275 ILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQ 308
RQL+ + QQ Q+ + ++Q Q+++
Sbjct: 796 ---RQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/135 (24%), Positives = 71/135 (52%), Gaps = 13/135 (9%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRR--------EEEERLRREEEERRRIEE 234
++E++++R E +R+ EE + R QK +E+ R E++ERL + + +RR E
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
R R E Q+++ A Q + + +++P +++Q+ R+L E ++ ++ Q
Sbjct: 174 WRQRQEWQEREERRAEEEQLQ-SCKGHETEEFP---DEEQLRRRELLELR-RKGREEKQQ 228
Query: 295 VQLAQQQAALQKQQE 309
+ +Q Q+++E
Sbjct: 229 QRRERQDRVFQEEEE 243
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/137 (25%), Positives = 73/137 (53%), Gaps = 18/137 (13%)
Query: 181 IEKEEQEKKRKEEEERRRREE---EERERLQKEEEKRRRE-----EEERLRREE------ 226
+E+EEQ ++R+ ++ + E+ E++ER + +E++R ++ EEER RR
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 227 --EERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
+E+ R E++ L+ E+++ Q + Q +QY ++ E+Q L+R+ +E+
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ--LLREEREKR 951
Query: 285 YQQYMQQLYQVQLAQQQ 301
+Q ++ Y+ QQ
Sbjct: 952 RRQERERQYRKDKKLQQ 968
Score = 44.3 bits (103), Expect = 3e-04
Identities = 28/110 (25%), Positives = 60/110 (54%), Gaps = 7/110 (6%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K + EQ ++ ++ + R R+ +++ + L E+++R RE+E R R ++ +R EEE+L
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR-RWQQRDRHFPEEEQLER 1301
Query: 240 EQQKQQIMAALNSQTAVQF------QQYAAQQYPGNYEQQQILIRQLQEQ 283
E+QK+ SQ Q ++ Q+ + +++ L+++ +EQ
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/63 (36%), Positives = 40/63 (63%), Gaps = 1/63 (1%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
KE + R++EE++RR E +R+ L++E +RRR++ + RE E E++ RLEQ+
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQ-LEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQR 164
Query: 243 KQQ 245
+Q
Sbjct: 165 DRQ 167
Score = 37.4 bits (85), Expect = 0.034
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 4/54 (7%)
Query: 175 YVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEE 228
+ K +EEQE + EEE++RR +ERER +EE RR+++EE+ R+ E
Sbjct: 1851 FATQEKSRREEQELWQ-EEEQKRR---QERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 35.0 bits (79), Expect = 0.17
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 6/58 (10%)
Query: 172 FSTYVASHKIEKE---EQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREE 226
F+T S + E+E E+E+KR++E ER+ REE R R QKEE +R + ++ +E
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQERERKLREEHIR-RQQKEE--QRHRQVGEIKSQE 1905
Score = 32.3 bits (72), Expect = 1.1
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Query: 200 EEEERERLQ-KEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQF 258
+EE+R R KE + R +EE RR E R++EEE + +QK+Q ++ Q
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 259 QQYAAQQYPGNYEQQQILIRQLQE 282
++ + + + L RQ QE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQE 179
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 71.2 bits (173), Expect = 2e-12
Identities = 54/188 (28%), Positives = 96/188 (51%), Gaps = 32/188 (17%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
+IE++++E++R EE++RR RE+ +LQ++E++RR E+ + LRREEE RR+ E E
Sbjct: 397 RIEEQKEERRRVEEQQRREREQR---KLQEKEQQRRLEDMQALRREEE-RRQAERE---- 448
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
Q+Y +Q Q + L RQLQ++H Y++ L Q Q Q
Sbjct: 449 -------------------QEYKRKQLE-EQRQSERLQRQLQQEH--AYLKSLQQQQ--Q 484
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
QQ ++QQ+ ++ G P P++ + + + T ++++ P A +
Sbjct: 485 QQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGS 544
Query: 360 NGPKESLP 367
GP+ +P
Sbjct: 545 TGPEPPIP 552
Score = 37.0 bits (84), Expect = 0.045
Identities = 45/185 (24%), Positives = 80/185 (43%), Gaps = 39/185 (21%)
Query: 160 EFVKLLNRCCHLFSTYVASHKIEK-------EEQEKKR------KEEEERRRREEEERER 206
+F+ ++ C L TY++ E+ +Q +R K+ +R R++ E+E
Sbjct: 261 KFIDFIDTC--LIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE- 317
Query: 207 LQKEEEKRRREEEERLRREEEERRRI---------EEERLRLEQQKQQIMAALNSQTAVQ 257
+ E E EEE+ EE E I E LRL+Q+ + AL Q +Q
Sbjct: 318 -ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQ 376
Query: 258 FQQ---------YAAQQYPGNYEQQQILIRQLQEQ----HYQQYMQQLYQVQLAQQQAAL 304
QQ + Q E+Q+ R+++EQ Q+ +Q+ Q + + AL
Sbjct: 377 QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQAL 436
Query: 305 QKQQE 309
++++E
Sbjct: 437 RREEE 441
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 69.3 bits (168), Expect = 8e-12
Identities = 43/137 (31%), Positives = 88/137 (64%), Gaps = 9/137 (6%)
Query: 179 HKIEKEEQEKKRKEEEERRRREEEERERLQKEEEK---RRREEEERLRREEEERRRIEEE 235
H E + + + ++++ + ++ +E++RLQ+++E+ ++ +E++ L+++E+ +++++E+
Sbjct: 142 HHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQ 201
Query: 236 RLRLEQQKQQI--MAALNSQTAVQFQQYAAQQYPGNYEQQQILIR---QLQEQHYQQYMQ 290
+L L+QQ++Q+ L Q +Q QQ+ QQ +QQ +L++ QLQ+Q QQ
Sbjct: 202 QL-LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQA 260
Query: 291 QLYQVQLAQQQAALQKQ 307
QL Q L QQQA LQ+Q
Sbjct: 261 QLQQQLLEQQQAQLQQQ 277
Score = 63.5 bits (153), Expect = 4e-10
Identities = 41/177 (23%), Positives = 95/177 (53%), Gaps = 6/177 (3%)
Query: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQ 244
+Q+++ +++ + ++ ++++E+LQ+++ +++E+ ++ + ++++ + ++++L L QQ+
Sbjct: 189 QQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQG 248
Query: 245 QIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIR--QLQEQHYQQYMQQLYQVQLAQQQ- 301
Q+ L Q Q QQ +Q +QQ +L + QLQ+Q QQ +QQ Q QL QQQ
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQ-QQEQLQQQQL 307
Query: 302 --AALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEE 356
L+ ++E V +P + + Q + +++L+ + EE
Sbjct: 308 QPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEE 364
Score = 62.0 bits (149), Expect = 1e-09
Identities = 43/183 (23%), Positives = 96/183 (52%), Gaps = 20/183 (10%)
Query: 184 EEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEER-------------- 229
+EQ++ ++++E+ + ++ +E++ LQ++E+ +++ +E++L ++++E+
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQ 224
Query: 230 -RRIEEERLRLEQQKQQIMAALNSQTAVQF-QQYAAQQYPGNYEQQQILIRQLQEQHYQQ 287
++ ++++ +L+QQ+Q ++ Q Q QQ AQ EQQQ ++Q Q+
Sbjct: 225 QQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQE 284
Query: 288 YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEK 347
+QQ Q QL QQQ +QQ++ P + V +M V+ ++ + +
Sbjct: 285 QLQQQQQQQLLQQQQEQLQQQQL----QPPPLEPEEEEEVELELMPVDLGSEQELEQQRQ 340
Query: 348 ELE 350
ELE
Sbjct: 341 ELE 343
Score = 58.9 bits (141), Expect = 1e-08
Identities = 33/122 (27%), Positives = 71/122 (58%), Gaps = 2/122 (1%)
Query: 186 QEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQ 245
Q++K + + + E + Q++ + ++ +E++RL++++E+ + + + ++ QQ++Q
Sbjct: 134 QQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQ 193
Query: 246 IMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQ 305
+ + Q +Q QQ QQ +Q+Q+ +Q Q+Q Q+ +QQ Q+ L QQQ LQ
Sbjct: 194 LQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ--QEQLQQQQQLLLLQQQGQLQ 251
Query: 306 KQ 307
+Q
Sbjct: 252 QQ 253
Score = 56.2 bits (134), Expect = 7e-08
Identities = 45/190 (23%), Positives = 91/190 (47%), Gaps = 15/190 (7%)
Query: 180 KIEKEEQEKKRKEE---EERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
++++E+ + +E E + ++++ + Q +E++R ++++E+L+ ++ + +++ +++
Sbjct: 132 QLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQ 191
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM------- 289
+L+QQ Q+ Q +Q QQ QQ +QQQ +Q Q Q QQ +
Sbjct: 192 EQLQQQVQEQQLLQQQQEQLQQQQLLQQQE--QLQQQQFQQQQEQLQQQQQLLLLQQQGQ 249
Query: 290 --QQLYQVQLAQ-QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSE 346
QQL Q Q AQ QQ L++QQ + L ++ ++ +
Sbjct: 250 LQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQP 309
Query: 347 KELEPEAAEE 356
LEPE EE
Sbjct: 310 PPLEPEEEEE 319
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/125 (24%), Positives = 69/125 (55%)
Query: 188 KKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIM 247
+++ +++ +++ + ++E+ Q + + E + + ++++ + + +E+ RL+QQ++Q+
Sbjct: 119 QQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQ 178
Query: 248 AALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQ 307
+ V QQ QQ + Q QLQ+Q Q +QL Q Q QQQ LQ+Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQ 238
Query: 308 QEVVV 312
Q++++
Sbjct: 239 QQLLL 243
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/125 (24%), Positives = 69/125 (55%), Gaps = 17/125 (13%)
Query: 193 EEERRRREEEERERLQKEEEKRRREEEERLRR-------EEEERRRIEEERLRLEQQKQQ 245
EE R + E + ++L+++ E +++ + E+L++ +++ ++ +++ +L+Q+K Q
Sbjct: 80 EETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQ 139
Query: 246 IMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQ 305
+ + +Q ++QQQ+ +Q+QEQ Q Q+ Q Q AQ+Q LQ
Sbjct: 140 SVHHQELKPELQLM----------HQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQ 189
Query: 306 KQQEV 310
+Q+++
Sbjct: 190 QQEQL 194
Score = 46.6 bits (109), Expect = 6e-05
Identities = 37/134 (27%), Positives = 71/134 (52%), Gaps = 10/134 (7%)
Query: 184 EEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER--LRLEQ 241
E+Q + +++ + + ++ + LQ++ ++ +++ +L++E+ + +E + L+L
Sbjct: 95 EQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMH 154
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHY---QQYMQ----QLYQ 294
Q+QQ+ Q + QQ Q ++QQ+L +Q Q Q QQ +Q QL Q
Sbjct: 155 QQQQLQPQ-QVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ 213
Query: 295 VQLAQQQAALQKQQ 308
QL QQQ LQ+QQ
Sbjct: 214 QQLLQQQEQLQQQQ 227
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/120 (25%), Positives = 66/120 (55%), Gaps = 5/120 (4%)
Query: 193 EEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL----EQQKQQIMA 248
+++ + +++++++ LQ+++E+ ++++ + E EE +E E + + EQ+ +Q
Sbjct: 281 QQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQ 340
Query: 249 ALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQ 308
L Q ++ QQ Q E+ Q L +QL++Q QQ QQ Q++L + Q+Q+
Sbjct: 341 ELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQ-QQLEQQEVQLELTPVELGAQQQE 399
Score = 42.0 bits (97), Expect = 0.001
Identities = 30/134 (22%), Positives = 76/134 (56%), Gaps = 14/134 (10%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIE--------E 234
+++Q + +++ E+++ + +++ LQ++E+ +++++++ L++++E+ ++ + E
Sbjct: 256 QQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPE 315
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E +E + + + Q Q+ QQ ++Q+ L +LQE+ +QQL Q
Sbjct: 316 EEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEE-----LQQLEQ 370
Query: 295 VQLAQQQAALQKQQ 308
QL QQQ L++Q+
Sbjct: 371 -QLEQQQQQLEQQE 383
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/133 (23%), Positives = 68/133 (51%), Gaps = 11/133 (8%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLR---------REEEERRRI 232
++E+ +++++++ ++++E+ ++++LQ + EEE L +E E++R+
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQE 341
Query: 233 EEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQL 292
E + LE+Q++Q L Q +Q + +Q EQQ++ + + Q QQ
Sbjct: 342 LERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQ--QQE 399
Query: 293 YQVQLAQQQAALQ 305
Q++L Q LQ
Sbjct: 400 VQLELTPVQPELQ 412
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 9/126 (7%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++++++Q++ ++++E+ ++++ + L+ EEE+ E E + + + +E++R L
Sbjct: 285 QLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEE--VELELMPVDLGSEQELEQQRQEL 342
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
E+Q++ Q ++ Q+ QQ EQQQ +QL++Q Q +L V+L
Sbjct: 343 ERQQELERQQEQRQLQLKLQE-ELQQLEQQLEQQQ---QQLEQQEVQ---LELTPVELGA 395
Query: 300 QQAALQ 305
QQ +Q
Sbjct: 396 QQQEVQ 401
Score = 39.3 bits (90), Expect = 0.009
Identities = 17/74 (22%), Positives = 48/74 (64%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
+ ++E++ QE +R++E ER++ + + + +LQ+E ++ ++ E++ ++ E++ ++E
Sbjct: 331 SEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTP 390
Query: 237 LRLEQQKQQIMAAL 250
+ L Q+Q++ L
Sbjct: 391 VELGAQQQEVQLEL 404
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 69.3 bits (168), Expect = 8e-12
Identities = 48/188 (25%), Positives = 97/188 (51%), Gaps = 5/188 (2%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K +++ Q++++++ E + +R+R +E+++ RR EE+ RRE E+R+ E+E+ R
Sbjct: 370 KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRR 429
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+ Q + + A + Q+Y +Q Q + L RQLQ++H Y++ L Q Q Q
Sbjct: 430 LEDMQALRREEERRQAEREQEYKRKQLE-EQRQSERLQRQLQQEH--AYLKSLQQQQ--Q 484
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
QQ ++QQ+ ++ G P P++ + + + T ++++ P A +
Sbjct: 485 QQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGS 544
Query: 360 NGPKESLP 367
GP+ +P
Sbjct: 545 TGPEPPIP 552
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 24/201 (11%)
Query: 176 VASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
V + + EQ K +++E++RR E+ + L++EEE+R+ E E+ +R++ E +R E
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRL---EDMQALRREEERRQAEREQEYKRKQLEEQRQSE- 463
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQE-QHYQQYMQQLYQ 294
RL++Q QQ A L S QQ QQ +QQQ+L + HY + M +
Sbjct: 464 --RLQRQLQQEHAYLKS-----LQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADK 516
Query: 295 VQLA---QQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP 351
A +++ + KQQ +A S P S+ +P G + T ++ +EP
Sbjct: 517 PAWAREVEERTRMNKQQNSPLA-KSKPGSTGPEPPIPQASPGPPGPL-SQTPPMQRPVEP 574
Query: 352 EAAEEALENGPKESLPVIAAP 372
+ GP +SL P
Sbjct: 575 -------QEGPHKSLVAHRVP 588
Score = 37.0 bits (84), Expect = 0.045
Identities = 45/185 (24%), Positives = 80/185 (43%), Gaps = 39/185 (21%)
Query: 160 EFVKLLNRCCHLFSTYVASHKIEK-------EEQEKKR------KEEEERRRREEEERER 206
+F+ ++ C L TY++ E+ +Q +R K+ +R R++ E+E
Sbjct: 261 KFIDFIDTC--LIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE- 317
Query: 207 LQKEEEKRRREEEERLRREEEERRRI---------EEERLRLEQQKQQIMAALNSQTAVQ 257
+ E E EEE+ EE E I E LRL+Q+ + AL Q +Q
Sbjct: 318 -ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQ 376
Query: 258 FQQ---------YAAQQYPGNYEQQQILIRQLQEQ----HYQQYMQQLYQVQLAQQQAAL 304
QQ + Q E+Q+ R+++EQ Q+ +Q+ Q + + AL
Sbjct: 377 QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQAL 436
Query: 305 QKQQE 309
++++E
Sbjct: 437 RREEE 441
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 69.3 bits (168), Expect = 8e-12
Identities = 48/188 (25%), Positives = 97/188 (51%), Gaps = 5/188 (2%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K +++ Q++++++ E + +R+R +E+++ RR EE+ RRE E+R+ E+E+ R
Sbjct: 370 KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRR 429
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+ Q + + A + Q+Y +Q Q + L RQLQ++H Y++ L Q Q Q
Sbjct: 430 LEDMQALRREEERRQAEREQEYKRKQLE-EQRQSERLQRQLQQEH--AYLKSLQQQQ--Q 484
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
QQ ++QQ+ ++ G P P++ + + + T ++++ P A +
Sbjct: 485 QQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGS 544
Query: 360 NGPKESLP 367
GP+ +P
Sbjct: 545 TGPEPPIP 552
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 24/201 (11%)
Query: 176 VASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
V + + EQ K +++E++RR E+ + L++EEE+R+ E E+ +R++ E +R E
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRL---EDMQALRREEERRQAEREQEYKRKQLEEQRQSE- 463
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQE-QHYQQYMQQLYQ 294
RL++Q QQ A L S QQ QQ +QQQ+L + HY + M +
Sbjct: 464 --RLQRQLQQEHAYLKS-----LQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADK 516
Query: 295 VQLA---QQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP 351
A +++ + KQQ +A S P S+ +P G + T ++ +EP
Sbjct: 517 PAWAREVEERTRMNKQQNSPLA-KSKPGSTGPEPPIPQASPGPPGPL-SQTPPMQRPVEP 574
Query: 352 EAAEEALENGPKESLPVIAAP 372
+ GP +SL P
Sbjct: 575 -------QEGPHKSLVAHRVP 588
Score = 37.0 bits (84), Expect = 0.045
Identities = 45/185 (24%), Positives = 80/185 (43%), Gaps = 39/185 (21%)
Query: 160 EFVKLLNRCCHLFSTYVASHKIEK-------EEQEKKR------KEEEERRRREEEERER 206
+F+ ++ C L TY++ E+ +Q +R K+ +R R++ E+E
Sbjct: 261 KFIDFIDTC--LIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE- 317
Query: 207 LQKEEEKRRREEEERLRREEEERRRI---------EEERLRLEQQKQQIMAALNSQTAVQ 257
+ E E EEE+ EE E I E LRL+Q+ + AL Q +Q
Sbjct: 318 -ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQ 376
Query: 258 FQQ---------YAAQQYPGNYEQQQILIRQLQEQ----HYQQYMQQLYQVQLAQQQAAL 304
QQ + Q E+Q+ R+++EQ Q+ +Q+ Q + + AL
Sbjct: 377 QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQAL 436
Query: 305 QKQQE 309
++++E
Sbjct: 437 RREEE 441
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 69.3 bits (168), Expect = 8e-12
Identities = 48/188 (25%), Positives = 97/188 (51%), Gaps = 5/188 (2%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
K +++ Q++++++ E + +R+R +E+++ RR EE+ RRE E+R+ E+E+ R
Sbjct: 370 KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRR 429
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+ Q + + A + Q+Y +Q Q + L RQLQ++H Y++ L Q Q Q
Sbjct: 430 LEDMQALRREEERRQAEREQEYKRKQLE-EQRQSERLQRQLQQEH--AYLKSLQQQQ--Q 484
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
QQ ++QQ+ ++ G P P++ + + + T ++++ P A +
Sbjct: 485 QQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGS 544
Query: 360 NGPKESLP 367
GP+ +P
Sbjct: 545 TGPEPPIP 552
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 24/201 (11%)
Query: 176 VASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEE 235
V + + EQ K +++E++RR E+ + L++EEE+R+ E E+ +R++ E +R E
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRL---EDMQALRREEERRQAEREQEYKRKQLEEQRQSE- 463
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQE-QHYQQYMQQLYQ 294
RL++Q QQ A L S QQ QQ +QQQ+L + HY + M +
Sbjct: 464 --RLQRQLQQEHAYLKS-----LQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADK 516
Query: 295 VQLA---QQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP 351
A +++ + KQQ +A S P S+ +P G + T ++ +EP
Sbjct: 517 PAWAREVEERTRMNKQQNSPLA-KSKPGSTGPEPPIPQASPGPPGPL-SQTPPMQRPVEP 574
Query: 352 EAAEEALENGPKESLPVIAAP 372
+ GP +SL P
Sbjct: 575 -------QEGPHKSLVAHRVP 588
Score = 37.0 bits (84), Expect = 0.045
Identities = 45/185 (24%), Positives = 80/185 (43%), Gaps = 39/185 (21%)
Query: 160 EFVKLLNRCCHLFSTYVASHKIEK-------EEQEKKR------KEEEERRRREEEERER 206
+F+ ++ C L TY++ E+ +Q +R K+ +R R++ E+E
Sbjct: 261 KFIDFIDTC--LIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE- 317
Query: 207 LQKEEEKRRREEEERLRREEEERRRI---------EEERLRLEQQKQQIMAALNSQTAVQ 257
+ E E EEE+ EE E I E LRL+Q+ + AL Q +Q
Sbjct: 318 -ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQ 376
Query: 258 FQQ---------YAAQQYPGNYEQQQILIRQLQEQ----HYQQYMQQLYQVQLAQQQAAL 304
QQ + Q E+Q+ R+++EQ Q+ +Q+ Q + + AL
Sbjct: 377 QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQAL 436
Query: 305 QKQQE 309
++++E
Sbjct: 437 RREEE 441
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 69.3 bits (168), Expect = 8e-12
Identities = 45/133 (33%), Positives = 80/133 (60%), Gaps = 7/133 (5%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
EK Q + +KE+EE+ R E+EE++RL++EE KR+ EEE RLR EEE R++ EEER R E+
Sbjct: 406 EKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEE-RLRLEEEARKQ-EEERKRQEE 463
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQY-----PGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
+K++ + + ++ A ++ +Q++ +I + +E + + Q++
Sbjct: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
Query: 297 LAQQQAALQKQQE 309
L ++Q LQ +QE
Sbjct: 524 LEREQIMLQIEQE 536
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/247 (25%), Positives = 116/247 (46%), Gaps = 25/247 (10%)
Query: 182 EKEEQEKKRKEEEER------RRREEEERERLQ----KEEEKRRREEEERLRRE------ 225
E+EEQE+ KEE++R +R+ EEER RL+ K+EE+R+R+EEE+ ++E
Sbjct: 416 EQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRK 475
Query: 226 --EEERRRIEEERLRLEQQKQQ----IMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ 279
EE +R+ EEE L E+Q+Q+ M + A + A+Q EQ + I Q
Sbjct: 476 AGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQ 535
Query: 280 LQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAK 339
+ + ++ + + + + + ++K+ V ++ K VP N M +NG
Sbjct: 536 ERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVEKKTKLVVP-NKMEINGLNT 594
Query: 340 THTDSSEKELEPEA-AEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVG 398
+ PE ++ NG K + +I ++ + D + Q D V V
Sbjct: 595 CQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMD-VSPVS 653
Query: 399 RGEVVTV 405
+ E++++
Sbjct: 654 KEELISI 660
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/56 (37%), Positives = 38/56 (67%)
Query: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
EQ+ K++ R + E++ ER +K EE+R+RE+++R EE+ ++++ EE RLE
Sbjct: 73 EQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLE 128
Score = 44.3 bits (103), Expect = 3e-04
Identities = 24/81 (29%), Positives = 53/81 (65%), Gaps = 2/81 (2%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQ--KEEEKRRREEEERLRREEEERRRIEEERLRL 239
E+ E+ +K E++ E+++R RLQ K+ E+R R+ EE+ +RE+++R +EE+R +
Sbjct: 60 ERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQK 119
Query: 240 EQQKQQIMAALNSQTAVQFQQ 260
+++++ + A+ ++ + QQ
Sbjct: 120 LREEEERLEAMMRRSLERTQQ 140
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/66 (30%), Positives = 44/66 (66%), Gaps = 2/66 (3%)
Query: 182 EKEEQEKKRKEEEER--RRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
E++ K+R+EE E+ RE++ E+ ++ + ++ EER R+ EE+R+R +++R +
Sbjct: 53 ERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAV 112
Query: 240 EQQKQQ 245
E++++Q
Sbjct: 113 EEKRKQ 118
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/67 (37%), Positives = 41/67 (61%), Gaps = 7/67 (10%)
Query: 184 EEQEKKR----KEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
E+Q++ R K+ EER R+ EE+R+R E++KR EE+R ++ EE R+E R
Sbjct: 78 EKQKRARLQYEKQMEERWRKLEEQRQR---EDQKRAAVEEKRKQKLREEEERLEAMMRRS 134
Query: 240 EQQKQQI 246
++ QQ+
Sbjct: 135 LERTQQL 141
Score = 37.7 bits (86), Expect = 0.026
Identities = 26/64 (40%), Positives = 41/64 (64%), Gaps = 6/64 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRR-REEEERLRREEEERRRIEEERLRLE 240
EK+ +E+ RK EE+R+R E+++ +E+ K++ REEEERL E RR E +LE
Sbjct: 88 EKQMEERWRKLEEQRQR--EDQKRAAVEEKRKQKLREEEERL---EAMMRRSLERTQQLE 142
Query: 241 QQKQ 244
+K+
Sbjct: 143 LKKK 146
Score = 37.4 bits (85), Expect = 0.034
Identities = 20/66 (30%), Positives = 40/66 (60%), Gaps = 2/66 (3%)
Query: 181 IEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
++ +E+++ KE E R + RE+ E++KR R + E+ + EE R++EE+R R +
Sbjct: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEK--QMEERWRKLEEQRQRED 106
Query: 241 QQKQQI 246
Q++ +
Sbjct: 107 QKRAAV 112
Score = 33.5 bits (75), Expect = 0.49
Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 12/102 (11%)
Query: 200 EEEERERLQKEEEKRRREEEERL--RREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQ 257
+ +ER+RL KE RREE E+ RE++ + + RL+ E+Q ++ L Q +
Sbjct: 50 KSDERQRLAKE----RREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
Query: 258 FQQYAA------QQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
Q+ AA Q+ E+ + ++R+ E+ Q +++ Y
Sbjct: 106 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKY 147
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 68.6 bits (166), Expect = 1e-11
Identities = 59/207 (28%), Positives = 111/207 (53%), Gaps = 28/207 (13%)
Query: 181 IEKEEQEK-------KRKEEEERRRREEEERERL--QKEEEKRRREEEERLRREEE--ER 229
+++EE+E+ K+KEEE+ R R+ E +RL Q+E+E+R +E E+ RRE+E E+
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
Query: 230 RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM 289
R E+ER EQ++++ L ++ +Q ++ A + Q++ L R+L+E+ ++
Sbjct: 711 ERREQERQLAEQERRREQERLQAERELQEREKALRL------QKEQLQRELEEKKKKEEQ 764
Query: 290 QQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVP---SNMMSVNGQ---AKTHTD 343
Q+L + QL ++Q K+ AG+S + V+ P S M+ G K + D
Sbjct: 765 QRLAERQLQEEQEKKAKE----AAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPD 820
Query: 344 SSEKELEPEAAEEALENGPKESLPVIA 370
+ +L + + + E P++ +P A
Sbjct: 821 NYGMDLNSDDSTDD-EAHPRKPIPTWA 846
Score = 68.6 bits (166), Expect = 1e-11
Identities = 56/185 (30%), Positives = 91/185 (49%), Gaps = 25/185 (13%)
Query: 180 KIEKEEQEKKRK--------EEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRR 231
K ++EEQE+ RK E+ E+ RRE+E RE+ ++E+E+R +E E+ R+ E+ RR
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
E+ERL+ E++ Q+ AL Q + Q ++ EQQ++ RQLQE+
Sbjct: 726 REQERLQAERELQEREKALRLQK--EQLQRELEEKKKKEEQQRLAERQLQEE-------- 775
Query: 292 LYQVQLAQQQAALQKQQEVVV-----AGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSE 346
Q + A++ A K V V A +S + + + P G DS++
Sbjct: 776 --QEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTD 833
Query: 347 KELEP 351
E P
Sbjct: 834 DEAHP 838
Score = 57.0 bits (136), Expect = 4e-08
Identities = 43/145 (29%), Positives = 75/145 (51%), Gaps = 22/145 (15%)
Query: 187 EKKRKEEEERRRREEEERERLQKEEE-KRRREEEERLRREE------EERRRIEEERLRL 239
EK+R+ E RR+EE E+ R QK EE KRRR EE +L+REE + R R+E+ +
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYP---------------GNYEQQQILIRQLQEQH 284
++Q +Q A ++ +T ++ A++ E++ +R LQ++
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
Query: 285 YQQYMQQLYQVQLAQQQAALQKQQE 309
++ Q+L Q + ++Q L+K E
Sbjct: 656 EERRHQELLQKKKEEEQERLRKAAE 680
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/134 (26%), Positives = 80/134 (59%), Gaps = 10/134 (7%)
Query: 184 EEQEKKRKEEE--ERRRREEEERERLQKEEEKRRREEEER----LRREEEERRRIEEERL 237
+E+ +K KEE E + +++ +++++ E +R++EEE R L++EEEERR E +
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
Query: 238 RLEQQKQQI-MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
+ E++++++ AA + A Q +Q +Q E+++ ++ +EQ ++ +QL + +
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE---QERREQERREQERQLAEQE 723
Query: 297 LAQQQAALQKQQEV 310
++Q LQ ++E+
Sbjct: 724 RRREQERLQAEREL 737
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 68.6 bits (166), Expect = 1e-11
Identities = 59/207 (28%), Positives = 111/207 (53%), Gaps = 28/207 (13%)
Query: 181 IEKEEQEK-------KRKEEEERRRREEEERERL--QKEEEKRRREEEERLRREEE--ER 229
+++EE+E+ K+KEEE+ R R+ E +RL Q+E+E+R +E E+ RRE+E E+
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
Query: 230 RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM 289
R E+ER EQ++++ L ++ +Q ++ A + Q++ L R+L+E+ ++
Sbjct: 707 ERREQERQLAEQERRREQERLQAERELQEREKALRL------QKEQLQRELEEKKKKEEQ 760
Query: 290 QQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVP---SNMMSVNGQ---AKTHTD 343
Q+L + QL ++Q K+ AG+S + V+ P S M+ G K + D
Sbjct: 761 QRLAERQLQEEQEKKAKE----AAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPD 816
Query: 344 SSEKELEPEAAEEALENGPKESLPVIA 370
+ +L + + + E P++ +P A
Sbjct: 817 NYGMDLNSDDSTDD-EAHPRKPIPTWA 842
Score = 68.6 bits (166), Expect = 1e-11
Identities = 56/185 (30%), Positives = 91/185 (49%), Gaps = 25/185 (13%)
Query: 180 KIEKEEQEKKRK--------EEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRR 231
K ++EEQE+ RK E+ E+ RRE+E RE+ ++E+E+R +E E+ R+ E+ RR
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Query: 232 IEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQ 291
E+ERL+ E++ Q+ AL Q + Q ++ EQQ++ RQLQE+
Sbjct: 722 REQERLQAERELQEREKALRLQK--EQLQRELEEKKKKEEQQRLAERQLQEE-------- 771
Query: 292 LYQVQLAQQQAALQKQQEVVV-----AGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSE 346
Q + A++ A K V V A +S + + + P G DS++
Sbjct: 772 --QEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTD 829
Query: 347 KELEP 351
E P
Sbjct: 830 DEAHP 834
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/151 (28%), Positives = 78/151 (51%), Gaps = 22/151 (14%)
Query: 181 IEKEEQEKKRKEEEERRRREEEERERLQKEEE-KRRREEEERLRREE------EERRRIE 233
+ + +EK+R+ E RR+EE E+ R QK EE KRRR EE +L+REE + R R+E
Sbjct: 526 LRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVE 585
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYP---------------GNYEQQQILIR 278
+ + ++Q +Q A ++ +T ++ A++ E++ +R
Sbjct: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
Query: 279 QLQEQHYQQYMQQLYQVQLAQQQAALQKQQE 309
LQ++ ++ Q+L Q + ++Q L+K E
Sbjct: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAE 676
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/134 (26%), Positives = 80/134 (59%), Gaps = 10/134 (7%)
Query: 184 EEQEKKRKEEE--ERRRREEEERERLQKEEEKRRREEEER----LRREEEERRRIEEERL 237
+E+ +K KEE E + +++ +++++ E +R++EEE R L++EEEERR E +
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
Query: 238 RLEQQKQQI-MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
+ E++++++ AA + A Q +Q +Q E+++ ++ +EQ ++ +QL + +
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE---QERREQERREQERQLAEQE 719
Query: 297 LAQQQAALQKQQEV 310
++Q LQ ++E+
Sbjct: 720 RRREQERLQAEREL 733
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/116 (29%), Positives = 66/116 (56%), Gaps = 14/116 (12%)
Query: 198 RREEEERERLQKEEEKRRREEEERLRRE--EEE-RRRIEEERLRLEQQKQQIMAALNSQT 254
R + +E+ER Q+ E RR+EE E+LRR+ EE+ RRR+EE +L+ E++ ++++ A +
Sbjct: 527 RMDPKEKER-QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA--RER 583
Query: 255 AVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEV 310
Q ++ +Q + Q + +E+ + + A+++AA +K +EV
Sbjct: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE--------EKAKKKAAAKKMEEV 631
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 68.2 bits (165), Expect = 2e-11
Identities = 44/128 (34%), Positives = 75/128 (58%), Gaps = 21/128 (16%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++E++EKK++EEEE+++REEEERER E+ RRE E R ++EEE R++ E E L+ Q
Sbjct: 815 KREQEEKKKQEEEEKKKREEEERER-----ERERREAELRAQQEEETRKQQELEALQKSQ 869
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
++ ++ L Q N + ++IL + + + Q+ + Q +L+ +
Sbjct: 870 KEAELTRELEKQKE-------------NKQVEEILRLEKEIEDLQRMKE---QQELSLTE 913
Query: 302 AALQKQQE 309
A+LQK QE
Sbjct: 914 ASLQKLQE 921
Score = 46.2 bits (108), Expect = 7e-05
Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 182 EKEEQEKKRKEEEERRRREEEER--------ERLQKEEEKRRREEEERLRREEEERRRIE 233
E+ E+E++R+E E R ++EEE R ++ QKE E R E+++ ++ EE R+E
Sbjct: 835 EERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLE 894
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQ 265
+E L++ K+Q +L + + Q+ Q+
Sbjct: 895 KEIEDLQRMKEQQELSLTEASLQKLQERRDQE 926
Score = 37.4 bits (85), Expect = 0.034
Identities = 23/72 (31%), Positives = 41/72 (56%), Gaps = 12/72 (16%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKE-EEKRRREEEERL-----------RREEEERR 230
++E E R+ E+++ ++ EE RL+KE E+ +R +E++ L R ++E R
Sbjct: 869 QKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELR 928
Query: 231 RIEEERLRLEQQ 242
R+EEE R Q+
Sbjct: 929 RLEEEACRAAQE 940
Score = 32.0 bits (71), Expect = 1.4
Identities = 19/64 (29%), Positives = 36/64 (56%), Gaps = 9/64 (14%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEE---------KRRREEEERLRREEEERRRIE 233
++++E K+ EE R +E E+ +R+++++E K + ++ LRR EEE R
Sbjct: 879 EKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRLEEEACRAA 938
Query: 234 EERL 237
+E L
Sbjct: 939 QEFL 942
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 67.8 bits (164), Expect = 2e-11
Identities = 47/143 (32%), Positives = 79/143 (55%), Gaps = 11/143 (7%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREE----EERERLQKEEEKRRREEEERLRREE----EE 228
A K +E+E++ EE ER R EE EER+R+ KEEEKR EE +R++ EE EE
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRI-KEEEKRAAEERQRIKEEEKRAAEE 355
Query: 229 RRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIR--QLQEQHYQ 286
R+RI+EE R +++Q+ A + V+ Q+ Q + Q+ I+ +++++
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
Query: 287 QYMQQLYQVQLAQQQAALQKQQE 309
+++ + + Q A L+KQ E
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQGE 438
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/233 (26%), Positives = 106/233 (45%), Gaps = 36/233 (15%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE------------EERLRREEEER 229
EK E+E K + E ER R E EERER++ E++K+ +E +ER RRE EER
Sbjct: 255 EKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Query: 230 RRIEEERLRLEQQKQQI-----MAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
R+ EE R +++Q+I AA Q + ++ AA++ E+++ + Q
Sbjct: 315 ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
Query: 285 YQQYMQQLYQVQLAQQQAALQK--QQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKT-- 340
++ + + Q +Q +K QE + G + K+ + + + +T
Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV--EQKIEGKWVNEKKAQEDKLQTAV 432
Query: 341 -HTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDAD 392
EK + +A E L+ E P + + +IKD EKI++D +
Sbjct: 433 LKKQGEEKGTKVQAKREKLQ----EDKPT------FKKEEIKD--EKIKKDKE 473
Score = 55.8 bits (133), Expect = 9e-08
Identities = 30/68 (44%), Positives = 50/68 (73%), Gaps = 3/68 (4%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEE--ERLRLE 240
K++Q++ E EE +++ EE R+ L++EE++R++EE +R REEEE+RR++E ER R E
Sbjct: 555 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 614
Query: 241 -QQKQQIM 247
+K+Q M
Sbjct: 615 AAEKRQKM 622
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/113 (30%), Positives = 62/113 (54%), Gaps = 6/113 (5%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREE--EERRRIEEERLRL 239
+K E+ +K EEEE+RR++EE +L++EEEKRR +EE RR E E+R+++ E+ L
Sbjct: 570 KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 629
Query: 240 EQQKQQIM----AALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQY 288
+++ + ++L + +F + Q+ G Q I + +QY
Sbjct: 630 DKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 682
Score = 53.5 bits (127), Expect = 5e-07
Identities = 49/206 (23%), Positives = 93/206 (45%), Gaps = 19/206 (9%)
Query: 192 EEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALN 251
E RR++ E RL+ E +R +++ E RRR +ERLR +Q+++ +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL----- 59
Query: 252 SQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ---QAALQKQQ 308
Q Q + A P + Q++ ++++L + + +Q Q AL++Q+
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 309 EVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPV 368
E PT + + ++PS M N A+ T +EKE + E+ +E E E++
Sbjct: 120 EFD------PTITDASLSLPSRRMQ-NDTAENET--TEKEEKSESRQERYEIEETETVTK 170
Query: 369 IAAPSMW--TRPQIKDFKEKIQQDAD 392
+ W K+ KEK +++ +
Sbjct: 171 SYQKNDWRDAEENKKEDKEKEEEEEE 196
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/221 (20%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREE-----EERRRIE--- 233
++EE+E+ E + EEE++ER + E + EE ER++ E+ +ER RIE
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE 299
Query: 234 ----EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM 289
+ER R E ++++ M + A + Q+ ++ E+Q+I + + +Q +
Sbjct: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
Query: 290 QQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKEL 349
++ + ++Q A +++E + K N + ++ + K + E+++
Sbjct: 360 KEEEKRAAEERQRARAEEEE-----KAKVEEQKRNKQLEEKKHAMQ-ETKIKGEKVEQKI 413
Query: 350 EPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQD 390
E + E K V+ +++ +EK+Q+D
Sbjct: 414 EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/177 (19%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
K+E+E+++ +E + EE ++ + E E+ R E EER R + E+ ++I +ER R+E +
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
++ + A + ++ ++ E+Q+I + + +Q +++ + ++Q
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 303 ALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
++++ + A V + + K H E +++ E E+ +E
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA-MQETKIKGEKVEQKIE 414
Score = 46.2 bits (108), Expect = 7e-05
Identities = 29/83 (34%), Positives = 46/83 (55%), Gaps = 14/83 (16%)
Query: 187 EKKRKEEEERRRREEEERERLQK------------EEEKRRREEEERLRREEEERRRIEE 234
E ++ EE RRRR E E E +K EE K++REE ++ EEE+RR+ EE
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
Query: 235 --ERLRLEQQKQQIMAALNSQTA 255
+LR E++K+++ + + A
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRA 613
Score = 36.6 bits (83), Expect = 0.058
Identities = 45/232 (19%), Positives = 97/232 (41%), Gaps = 12/232 (5%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A + + EE + + E ERL + EE+R++ +E L R++E I +
Sbjct: 70 AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDAS 129
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
L L ++ Q A N +T + ++ ++Q E+ + + + Q+ ++ + + +
Sbjct: 130 LSLPSRRMQNDTAEN-ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK 188
Query: 297 LAQQQAALQK------QQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELE 350
+++ + + +V V T S+ V M NGQ + E+E E
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV---MSLKNGQISSEEPKQEEERE 245
Query: 351 PEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEV 402
+ ++E + E A + R + ++ +E+I+ + D I R +
Sbjct: 246 -QGSDEISHHEKMEEEDKERAEAERARLEAEE-RERIKAEQDKKIADERARI 295
Score = 36.2 bits (82), Expect = 0.076
Identities = 33/180 (18%), Positives = 81/180 (45%), Gaps = 12/180 (6%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
+ E EE E K ++ R+ EE ++ KE+E+ E+ +R E + + EE+
Sbjct: 159 RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE 218
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
Q++ +M+ N Q + + + ++ G+ E +++E+ ++ + +++ A+
Sbjct: 219 SQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH--HEKMEEEDKERAEAERARLE-AE 275
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
++ ++ +Q+ +A ++ A Q + ++ E+E E + A E
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAA---------AQERERREAEERERMREEEKRAAE 326
Score = 33.5 bits (75), Expect = 0.49
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 7/94 (7%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A K+ +EE++++ KEE ERRR E E+ + E+ ++ + + +IEE
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 650
Query: 237 LRLEQQKQQI-------MAALNSQTAVQFQQYAA 263
L + Q+ AA+ S+ + +QY +
Sbjct: 651 EFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTS 684
Score = 33.1 bits (74), Expect = 0.64
Identities = 16/60 (26%), Positives = 39/60 (65%), Gaps = 8/60 (13%)
Query: 182 EKEEQEKK------RKEEEERRRREEEERERLQKEEEKRRREE--EERLRREEEERRRIE 233
EK+ QE K +K+ EE+ + + +RE+LQ+++ ++EE +E++++++E + ++
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/129 (32%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++E +E KR+ ER++R EE++E+ ++ EE++RRE+E R ++E E+RR EE+ R E+
Sbjct: 377 QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
+++ A Q+Y +Q EQ+Q+ I Q Q H Q + + + QL +Q+
Sbjct: 437 RRR----------AEHEQEYIRRQL--EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQR 484
Query: 302 AALQKQQEV 310
A + Q+++
Sbjct: 485 QAERLQRQL 493
Score = 65.5 bits (158), Expect = 1e-10
Identities = 63/229 (27%), Positives = 113/229 (49%), Gaps = 26/229 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRRE---EEERERLQKEEEKRRREEEERLRREEEE--RRRIEE 234
+IE+++++++R EE++RR +E ++ERE+ + EE+ RREEE R E+E RR++EE
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E+ +LE +QQ+ L+ Q + +Y +Q + +++ + QE+ Y +Q Q
Sbjct: 454 EQRQLEILQQQL---LHEQALL--LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
Query: 295 VQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP--- 351
Q ++ L +E G S P+ A ++++V Q T S +P
Sbjct: 509 EQRPVEKKPLYHYKE----GMS-PSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKG 563
Query: 352 -EAAEEAL-------ENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDAD 392
+EAL E + S P P + TR + D ++Q+ D
Sbjct: 564 LSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED 612
Score = 53.5 bits (127), Expect = 5e-07
Identities = 49/215 (22%), Positives = 100/215 (46%), Gaps = 4/215 (1%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ K+++ ++R+ EE+ RREEE R ++E RR+ EEE+ + E +++ + E+ L L
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
E +++Q+ ++ +Q Q + Y + + Q+ R ++++ Y + + +
Sbjct: 474 EYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
+ V G +L S V+ P+ +S Q + S E+ + ++ E
Sbjct: 533 WAKEIPHLVAVKSQGPALTASQSVHEQ-PTKGLS-GFQEALNVTSHRVEMPRQNSDPTSE 590
Query: 360 NGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSV 394
N P + S W R Q +D K+ Q S+
Sbjct: 591 NPPLPTRIEKFDRSSWLR-QEEDIPPKVPQRTTSI 624
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/129 (32%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++E +E KR+ ER++R EE++E+ ++ EE++RRE+E R ++E E+RR EE+ R E+
Sbjct: 377 QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
+++ A Q+Y +Q EQ+Q+ I Q Q H Q + + + QL +Q+
Sbjct: 437 RRR----------AEHEQEYIRRQL--EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQR 484
Query: 302 AALQKQQEV 310
A + Q+++
Sbjct: 485 QAERLQRQL 493
Score = 65.5 bits (158), Expect = 1e-10
Identities = 63/229 (27%), Positives = 113/229 (49%), Gaps = 26/229 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRRE---EEERERLQKEEEKRRREEEERLRREEEE--RRRIEE 234
+IE+++++++R EE++RR +E ++ERE+ + EE+ RREEE R E+E RR++EE
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E+ +LE +QQ+ L+ Q + +Y +Q + +++ + QE+ Y +Q Q
Sbjct: 454 EQRQLEILQQQL---LHEQALL--LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
Query: 295 VQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEP--- 351
Q ++ L +E G S P+ A ++++V Q T S +P
Sbjct: 509 EQRPVEKKPLYHYKE----GMS-PSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKG 563
Query: 352 -EAAEEAL-------ENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDAD 392
+EAL E + S P P + TR + D ++Q+ D
Sbjct: 564 LSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED 612
Score = 53.5 bits (127), Expect = 5e-07
Identities = 49/215 (22%), Positives = 100/215 (46%), Gaps = 4/215 (1%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ K+++ ++R+ EE+ RREEE R ++E RR+ EEE+ + E +++ + E+ L L
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
E +++Q+ ++ +Q Q + Y + + Q+ R ++++ Y + + +
Sbjct: 474 EYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 300 QQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALE 359
+ V G +L S V+ P+ +S Q + S E+ + ++ E
Sbjct: 533 WAKEIPHLVAVKSQGPALTASQSVHEQ-PTKGLS-GFQEALNVTSHRVEMPRQNSDPTSE 590
Query: 360 NGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSV 394
N P + S W R Q +D K+ Q S+
Sbjct: 591 NPPLPTRIEKFDRSSWLR-QEEDIPPKVPQRTTSI 624
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/129 (32%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++E +E KR+ ER++R EE++E+ ++ EE++RRE+E R ++E E+RR EE+ R E+
Sbjct: 377 QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
+++ A Q+Y +Q EQ+Q+ I Q Q H Q + + + QL +Q+
Sbjct: 437 RRR----------AEHEQEYIRRQL--EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQR 484
Query: 302 AALQKQQEV 310
A + Q+++
Sbjct: 485 QAERLQRQL 493
Score = 62.8 bits (151), Expect = 8e-10
Identities = 42/135 (31%), Positives = 79/135 (58%), Gaps = 10/135 (7%)
Query: 180 KIEKEEQEKKRKEEEERRRRE---EEERERLQKEEEKRRREEEERLRREEEE--RRRIEE 234
+IE+++++++R EE++RR +E ++ERE+ + EE+ RREEE R E+E RR++EE
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E+ +LE +QQ+ L+ Q + +Y +Q + +++ + QE+ Y +Q Q
Sbjct: 454 EQRQLEILQQQL---LHEQALL--LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
Query: 295 VQLAQQQAALQKQQE 309
Q ++ L +E
Sbjct: 509 EQRPVEKKPLYHYKE 523
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/179 (22%), Positives = 89/179 (49%), Gaps = 7/179 (3%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ K+++ ++R+ EE+ RREEE R ++E RR+ EEE+ + E +++ + E+ L L
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQ---HYQQYMQQLYQVQ 296
E +++Q+ ++ +Q Q + Y + + Q+ R ++++ HY++ M +
Sbjct: 474 EYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 297 LA---QQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPE 352
A ++++ L +Q + S N S S++G T + ++P+
Sbjct: 533 WAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ 591
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/129 (32%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++E +E KR+ ER++R EE++E+ ++ EE++RRE+E R ++E E+RR EE+ R E+
Sbjct: 377 QRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
+++ A Q+Y +Q EQ+Q+ I Q Q H Q + + + QL +Q+
Sbjct: 437 RRR----------AEHEQEYIRRQL--EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQR 484
Query: 302 AALQKQQEV 310
A + Q+++
Sbjct: 485 QAERLQRQL 493
Score = 62.8 bits (151), Expect = 8e-10
Identities = 42/135 (31%), Positives = 79/135 (58%), Gaps = 10/135 (7%)
Query: 180 KIEKEEQEKKRKEEEERRRRE---EEERERLQKEEEKRRREEEERLRREEEE--RRRIEE 234
+IE+++++++R EE++RR +E ++ERE+ + EE+ RREEE R E+E RR++EE
Sbjct: 394 RIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 235 ERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E+ +LE +QQ+ L+ Q + +Y +Q + +++ + QE+ Y +Q Q
Sbjct: 454 EQRQLEILQQQL---LHEQALL--LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
Query: 295 VQLAQQQAALQKQQE 309
Q ++ L +E
Sbjct: 509 EQRPVEKKPLYHYKE 523
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/179 (22%), Positives = 89/179 (49%), Gaps = 7/179 (3%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ K+++ ++R+ EE+ RREEE R ++E RR+ EEE+ + E +++ + E+ L L
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQ---HYQQYMQQLYQVQ 296
E +++Q+ ++ +Q Q + Y + + Q+ R ++++ HY++ M +
Sbjct: 474 EYKRKQLEEQRQAE-RLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 297 LA---QQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPE 352
A ++++ L +Q + S N S S++G T + ++P+
Sbjct: 533 WAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ 591
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 66.2 bits (160), Expect = 7e-11
Identities = 32/65 (49%), Positives = 51/65 (78%), Gaps = 1/65 (1%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKE-EEKRRREEEERLRREEEERRRIEEERLRLE 240
E+ E+E+KR+EE+E+RRR+EEE R++ E E KR++EEEER +RE++E+R E +L
Sbjct: 931 EEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLA 990
Query: 241 QQKQQ 245
+QK++
Sbjct: 991 RQKEE 995
Score = 56.2 bits (134), Expect = 7e-08
Identities = 38/137 (27%), Positives = 72/137 (52%), Gaps = 9/137 (6%)
Query: 152 MSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRK-----EEEERRRREEEERER 206
M++E E+ L+ L S + K ++EE E+ R+ E+E +RR E+E+R R
Sbjct: 890 MTQEQIQKEYDALVKSSEELLSA-LQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRR 948
Query: 207 LQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQY 266
++EE + + E E + ++EEEER++ E++ R++ ++ A L Q + QQ A +
Sbjct: 949 KEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQ---AEVEAQLARQKEEESQQQAVLEQ 1005
Query: 267 PGNYEQQQILIRQLQEQ 283
+ + I Q + +
Sbjct: 1006 ERRDRELALRIAQSEAE 1022
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/140 (30%), Positives = 64/140 (45%), Gaps = 29/140 (20%)
Query: 155 EDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQK----E 210
+D E K + T +A K QE+ +KE + + EE LQK E
Sbjct: 861 KDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQE 920
Query: 211 E--------------EKRRREEEERLRREEEERRRI-----------EEERLRLEQQKQQ 245
E E++RREE+E+ RR+EEE RR+ EEER + E +++
Sbjct: 921 EEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKR 980
Query: 246 IMAALNSQTAVQFQQYAAQQ 265
I A + +Q A Q ++ + QQ
Sbjct: 981 IQAEVEAQLARQKEEESQQQ 1000
Score = 42.7 bits (99), Expect = 8e-04
Identities = 24/69 (34%), Positives = 40/69 (57%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
++EE+ KKR+++E+R + E E + QKEEE +++ E+ RR+ E RI + L
Sbjct: 966 QEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELIS 1025
Query: 242 QKQQIMAAL 250
+ Q AL
Sbjct: 1026 DEAQADLAL 1034
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 6/72 (8%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEE---KRRREEEERLRREEEERRRIEEER 236
K+E E + K+ +EE R++ E++ +R+Q E E R++EEE + + E+ RR E
Sbjct: 957 KLEMEAKRKQEEEE---RKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELA 1013
Query: 237 LRLEQQKQQIMA 248
LR+ Q + ++++
Sbjct: 1014 LRIAQSEAELIS 1025
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 18/71 (25%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQ----------KEEEKR--------RREEEERLRR 224
K E E KRK+EEE R++ E++ +R+Q KEEE + RR+ E LR
Sbjct: 957 KLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRI 1016
Query: 225 EEEERRRIEEE 235
+ E I +E
Sbjct: 1017 AQSEAELISDE 1027
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 66.2 bits (160), Expect = 7e-11
Identities = 56/202 (27%), Positives = 98/202 (48%), Gaps = 24/202 (11%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
EK ++++E+EER RRE+EE ER QK EE +R EER R EEE RR+E E+ R ++
Sbjct: 485 EKRRLAREQREKEERERREQEELER-QKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
Query: 242 QKQQIMA---ALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ---- 294
++ Q A AL + + Q ++ ++ +RQ +E+H+Q+ Q+ +
Sbjct: 544 EQLQRQAEERALREREEAERAQRQKEE-EARVREEAERVRQEREKHFQREEQERLERKKR 602
Query: 295 ----VQLAQQQAALQK----QQEVVVAGSSLPTSSKVNATVPSNMMSVNGQ-------AK 339
++ ++ A K Q+ +A +L ++V+A + NG+
Sbjct: 603 LEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVT 662
Query: 340 THTDSSEKELEPEAAEEALENG 361
+H E P+ ++ ENG
Sbjct: 663 SHQSKVTVESTPDLEKQPNENG 684
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/121 (27%), Positives = 65/121 (53%), Gaps = 5/121 (4%)
Query: 192 EEEERRRREEEERERLQKEEEKRRREEEERLRRE--EEERRRIEEER-LRLEQQKQQIMA 248
EE R E+ R Q+E+E+R R E+E L R+ EE +R+ EER R E++ +++ A
Sbjct: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
Query: 249 ALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQ 308
+ Q Q+ A ++ E+ + RQ +E+ + ++ +V+ +++ +++Q
Sbjct: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEE--ARVREEAERVRQEREKHFQREEQ 594
Query: 309 E 309
E
Sbjct: 595 E 595
Score = 43.9 bits (102), Expect = 4e-04
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 9/74 (12%)
Query: 183 KEEQEKK---------RKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIE 233
+EE+EK+ +EE R+ E+ ER ++ EE+R++EE R EE+ R+R+E
Sbjct: 74 REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLE 133
Query: 234 EERLRLEQQKQQIM 247
E++ R E ++ M
Sbjct: 134 EDKERHEAVVRRTM 147
Score = 43.5 bits (101), Expect = 5e-04
Identities = 23/74 (31%), Positives = 44/74 (59%), Gaps = 10/74 (13%)
Query: 182 EKEEQEKKRKEEEERR---------RREEEERERLQKEEEKRRREEEERLRREEEERRRI 232
+++ ++R+EE E++ REE R+ +K E+R++ EE+ ++EE R +
Sbjct: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
Query: 233 EEE-RLRLEQQKQQ 245
EE+ R RLE+ K++
Sbjct: 125 EEKRRQRLEEDKER 138
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/67 (38%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 181 IEKEEQEKKRKEE--EERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLR 238
+E+EE+ ++ E+ EER++R EE+R QKEE +R EE+R +R EE++ R E R
Sbjct: 89 LEREERARQHYEKHLEERKKRLEEQR---QKEERRRAAVEEKRRQRLEEDKERHEAVVRR 145
Query: 239 LEQQKQQ 245
++ Q+
Sbjct: 146 TMERSQK 152
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/60 (38%), Positives = 37/60 (61%), Gaps = 3/60 (5%)
Query: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
A EK +E+K++ EE+R++ EER R EE++R+R EE++ R E RR +E +
Sbjct: 95 ARQHYEKHLEERKKRLEEQRQK---EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ 151
Score = 38.5 bits (88), Expect = 0.015
Identities = 18/58 (31%), Positives = 35/58 (60%)
Query: 179 HKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEER 236
H E++++ ++++++EERRR EE+ R + EE+K R E R E ++ + + R
Sbjct: 102 HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
Score = 36.2 bits (82), Expect = 0.076
Identities = 17/63 (26%), Positives = 38/63 (60%), Gaps = 2/63 (3%)
Query: 184 EEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQK 243
+++++ +E E R ++ RE + E E+R R+ E+ EE ++R+EE+R + E+++
Sbjct: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRR 121
Query: 244 QQI 246
+
Sbjct: 122 AAV 124
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 65.5 bits (158), Expect = 1e-10
Identities = 55/234 (23%), Positives = 110/234 (47%), Gaps = 34/234 (14%)
Query: 184 EEQEKKRKEEEERRRREEE--ERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
+EQEKK ++EE+ R EE ERE+ +EEE+ RE+EE+++ +EE+ R EE+ E+
Sbjct: 543 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE 602
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQ 301
+ Q+ + Q ++ Q+ ++Q+ ++ + +E+ +Q + Q + ++Q
Sbjct: 603 KMQEQEEKMWEQEEKMWE----QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 302 AALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEK---ELEPEAAEEAL 358
++QE + G + + GQ + + EK + E +E
Sbjct: 659 EEKMREQEEKMQGQ--------EEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEK 710
Query: 359 ENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEE 412
G +E MW + ++++ +E+I+ + E + R+P HEE
Sbjct: 711 MWGQEE--------KMWGQEEMREKEERIRD---------QKEKMQERLPEHEE 747
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/132 (30%), Positives = 74/132 (56%), Gaps = 8/132 (6%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRRE----EEERLRREEEERRRIEEERL 237
EQ+++ +E+EER R +E E+ E++Q+EE R RE EEE RE+EE+ + +EE +
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
+++K+ L Q ++Q Q+ +Q+ IR QE+ + Q + Q ++
Sbjct: 423 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD-QEEMWGQEKKMWRQEKM 481
Query: 298 AQQQAALQKQQE 309
+Q+ + +Q+E
Sbjct: 482 REQEDQMWEQEE 493
Score = 58.2 bits (139), Expect = 2e-08
Identities = 47/224 (20%), Positives = 111/224 (49%), Gaps = 14/224 (6%)
Query: 182 EKEEQEKKRKEEEERRRREEE---ERERLQKEEEKRRREEEERLRREEEERRRIEE---E 235
E EQEKK +++EE+ R+EE E+E +E+E++ R +E+RLR +E+E R E+ E
Sbjct: 242 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE 301
Query: 236 RLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQV 295
+ +L +Q++Q+ + + ++ +Q + Q++ L Q ++ Q+ + +
Sbjct: 302 QKKLREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 296 QLAQQQAALQKQQEVVVAGSSL---PTSSKVNATVPSNMMSVNGQAKTHTDSSEK--ELE 350
++ +Q L++++E + + + + + + +T + EK + E
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 351 PEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSV 394
E+ + ++ LP +W + ++++ +EKI + + +
Sbjct: 420 ENMWEQEEKEWQQQRLPE-QKEKLWEQEKMQEQEEKIWEQEEKI 462
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/135 (25%), Positives = 76/135 (56%), Gaps = 7/135 (5%)
Query: 182 EKEEQEKKRKEEEERRRREEE---ERERLQKEEEKRRREEEERLRREEEERRRIEEERLR 238
EK +E++ +E E++ R EEE E+E +E+E++ RE+EE++ +EE+ + EE+
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 239 LEQQ--KQQIMAALNSQTAVQFQQ--YAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E++ +Q+ + Q + ++Q +Q +EQ++ + Q ++ Q+ Q +
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 295 VQLAQQQAALQKQQE 309
++ +Q+ +Q Q+E
Sbjct: 674 EKMREQEEKMQGQEE 688
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/133 (29%), Positives = 83/133 (62%), Gaps = 13/133 (9%)
Query: 182 EKEEQEKKRKEEEERRRREEEE---RERLQKEEEKRRREEEERLRREEEERRRIEEERLR 238
E QE++ +E+E++ R++EE+ +E +E+E + RE+EE++RR +E+R R +E+ LR
Sbjct: 235 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR-QEKRLREQEKELR 293
Query: 239 LEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY--QVQ 296
EQ+K+ L Q ++ Q+ Q+ +Q+ +R+ +E+ ++Q ++L+ + Q
Sbjct: 294 -EQEKE-----LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ-EERLWEQEKQ 346
Query: 297 LAQQQAALQKQQE 309
+ +Q+ ++ Q+E
Sbjct: 347 MREQEQKMRDQEE 359
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/217 (18%), Positives = 104/217 (47%), Gaps = 5/217 (2%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+E++EK R++E+ R +E+E RE+ ++ E+++ E+E +E+EE+ +EE++R +++
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEE 331
Query: 243 K--QQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
K +Q + ++ Q+ + +Q +R+ +E+ +Q + ++ ++
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEE 391
Query: 301 QAALQKQQEVVVAGSSLPTSSKVNATVPSNMM---SVNGQAKTHTDSSEKELEPEAAEEA 357
+ ++++++ ++ + NM Q + + EK E E +E
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 358 LENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSV 394
E ++ + MW + + +EK+++ D +
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/132 (25%), Positives = 77/132 (58%), Gaps = 8/132 (6%)
Query: 186 QEKKRKEEEERRRREEEERERLQK--EEEKRRREEEERLRREEEERRR-----IEEERLR 238
QEK R++E++ +EE+ R++ QK ++E+R E++ERLR +EE R +EE++R
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMR 537
Query: 239 LEQQKQ-QIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
E++ Q Q + + ++ ++ ++ E+++++ Q ++ Q+ + + ++
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Query: 298 AQQQAALQKQQE 309
+Q+ +Q+Q+E
Sbjct: 598 WEQEEKMQEQEE 609
Score = 50.1 bits (118), Expect = 5e-06
Identities = 28/126 (22%), Positives = 71/126 (56%), Gaps = 3/126 (2%)
Query: 186 QEKKRKEEEERRRREEE--ERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQK 243
QEKK +E+ R +E++ E+E +++E++ ++EER+ E++ER R +EER+R +++
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMW-EQDERLREKEERMREQKKM 529
Query: 244 QQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAA 303
Q + + Q Q+ +++ + + ++ ++ M + + ++ +Q+
Sbjct: 530 WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 589
Query: 304 LQKQQE 309
+++Q+E
Sbjct: 590 MREQEE 595
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/140 (23%), Positives = 71/140 (50%), Gaps = 14/140 (10%)
Query: 184 EEQEKKRKEEEERRRREEEE--------RERLQKEEEKRRREEEERLRREE------EER 229
+EQE+K E+EE+ R +EE R+ +E+E + E+EE++R +E EER
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 230 RRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYM 289
++ERLR ++++ + + Q ++ Q+ Q+ +R+ + ++
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 290 QQLYQVQLAQQQAALQKQQE 309
+ + + +Q+ +Q+Q+E
Sbjct: 569 MREEEEMMREQEEKMQEQEE 588
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/174 (20%), Positives = 79/174 (45%), Gaps = 11/174 (6%)
Query: 183 KEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQ 242
+EE+E R++EE+ +++EE E+ +KE +++R E++ E+E+ + EE+ E++
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 243 KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQA 302
+ + + Q+ +Q +EQ++ + Q Q+ Q+ +L +++
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521
Query: 303 ALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEE 356
+++Q+++ + K Q K D EK E E E
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQE-----------QEKKTWDQEEKMREEERMRE 564
Score = 42.7 bits (99), Expect = 8e-04
Identities = 35/145 (24%), Positives = 72/145 (49%), Gaps = 23/145 (15%)
Query: 181 IEKEEQEKKRKEEEERRRREEEERERLQK--EEEKRRRE--------------EEERLRR 224
I EE +KK E +E+ R E E+ +Q +E KR+ E +EE R+
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239
Query: 225 EEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
EEE R +E+++R +++K + ++ Q+ ++ +Q+ +R+ +++
Sbjct: 240 EEELRE--QEKKIRKQEEKM-----WRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 285 YQQYMQQLYQVQLAQQQAALQKQQE 309
+Q + Q +L +Q+ +Q+Q+E
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEE 317
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/133 (20%), Positives = 72/133 (54%), Gaps = 6/133 (4%)
Query: 183 KEEQEKKRKEEEERRRREE---EERERLQKEEEK---RRREEEERLRREEEERRRIEEER 236
+E ++K R+EEE R +EE ++ E + ++EEK ++R E++ + E+E+ + +EE+
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 237 LRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
+ +++K + + Q ++Q ++ +Q+ +R +++ + Q + Q +
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514
Query: 297 LAQQQAALQKQQE 309
+++ ++Q+
Sbjct: 515 RLREKEERMREQK 527
Score = 39.7 bits (91), Expect = 0.007
Identities = 30/150 (20%), Positives = 81/150 (54%), Gaps = 20/150 (13%)
Query: 182 EKEEQEKKRKEEEER---RRREEEERERLQKEEEKRRREEE----------ERLRREEEE 228
EKE Q+++ E++E+ + + +E+ E++ ++EEK R +EE + RE+E+
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 229 RRRIEEERLRLEQQK----QQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
+ +EE++R ++QK ++ M + + + ++ Q+ E++ ++ QEQ
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546
Query: 285 ---YQQYMQQLYQVQLAQQQAALQKQQEVV 311
+ Q + + ++ +++ +++++E++
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMM 576
Score = 31.2 bits (69), Expect = 2.4
Identities = 21/60 (35%), Positives = 38/60 (63%), Gaps = 10/60 (16%)
Query: 183 KEEQEKKRKEEEERRRREEE----ERERLQKEEEKRRREEEERLRREEEERRRIEEERLR 238
+EE+ + E+EE+ R +EE + E++ +EEK +EE RE+EER R ++E+++
Sbjct: 686 QEEKMR---EQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE---MREKEERIRDQKEKMQ 739
Score = 30.8 bits (68), Expect = 3.2
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 21/74 (28%)
Query: 182 EKEE----QEKKRKEEEERRRREEEE-----------------RERLQKEEEKRRREEEE 220
E+EE QE+K +E+EE+ R +EE+ +E ++++EE+ R ++E+
Sbjct: 678 EQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737
Query: 221 RLRREEEERRRIEE 234
R E R E
Sbjct: 738 MQERLPEHEERCSE 751
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/136 (25%), Positives = 78/136 (57%), Gaps = 7/136 (5%)
Query: 176 VASHKIEKEEQEKKRKEEEERRRREEEE--RERLQKEEEKRRREEEERLRREEEERRRIE 233
V + + +QE++ +E+EE+ R +EE+ +++ Q E+E++ E+EE++R +EE+ R E
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE 309
Query: 234 EERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
E+ E+Q ++ + Q ++Q +EQ++ + +Q ++ Q+ Q
Sbjct: 310 EQMREQEEQMREQEEQMGKQEEQMWEQKEQM-----WEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 294 QVQLAQQQAALQKQQE 309
+ Q+ +Q+ ++KQ+E
Sbjct: 365 EEQVRKQEEQMRKQEE 380
Score = 63.5 bits (153), Expect = 4e-10
Identities = 38/130 (29%), Positives = 78/130 (60%), Gaps = 5/130 (3%)
Query: 184 EEQEKKRKEEEERRRREEE---ERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
E++E+ RK+EE+ +EE+ + E++QK+EE+ R++EE+ +R +EE+ R EE+ L+ +
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ-MREQEEQMREQEEQMLKQK 282
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ-VQLAQ 299
+Q +Q + ++ Q+ ++ +Q+ +R+ +EQ +Q Q Q Q+ +
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE 342
Query: 300 QQAALQKQQE 309
Q+ + KQ+E
Sbjct: 343 QKEQMWKQEE 352
Score = 60.1 bits (144), Expect = 5e-09
Identities = 38/130 (29%), Positives = 77/130 (59%), Gaps = 10/130 (7%)
Query: 182 EKEEQEKKRKE--EEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
E+EEQ K+KE E+E + E+EE+ R E+E++ RE+EE++R +EE+ R EE+ +
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMR---EQEEQMREQEEQMREQEEQMREQEEQ---M 326
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
+Q++Q+ + Q + ++ G EQ++ + +Q ++ Q+ + + Q+ +
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQEEQMG--EQEEQMQKQEEQVRKQEEQMRKQEEQMRK 384
Query: 300 QQAALQKQQE 309
Q+ ++KQ+E
Sbjct: 385 QEEQMRKQEE 394
Score = 59.7 bits (143), Expect = 6e-09
Identities = 38/132 (28%), Positives = 79/132 (59%), Gaps = 10/132 (7%)
Query: 185 EQEKKRKEEEERRRREEE---ERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
EQE++ E+EE+ +++EE E+E +++E++ E+EE+++++EE+ ++ EE+ + E+
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 242 Q---KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ-VQL 297
Q +++ M Q Q +Q ++ G E+Q +R+ +EQ +Q Q Q Q+
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ---MREQEEQMREQEEQMREQEEQM 319
Query: 298 AQQQAALQKQQE 309
+Q+ + KQ+E
Sbjct: 320 REQEEQMGKQEE 331
Score = 59.7 bits (143), Expect = 6e-09
Identities = 32/131 (24%), Positives = 77/131 (58%), Gaps = 1/131 (0%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
E+EEQ +K++E+ +++ + ++E +E+E++ RE+EE++ +++E+ + E+ + EQ
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 242 QKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ-VQLAQQ 300
++Q + ++ Q+ ++ +Q+ + + +EQ ++Q Q Q Q+ +Q
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQ 357
Query: 301 QAALQKQQEVV 311
+ +QKQ+E V
Sbjct: 358 EEQMQKQEEQV 368
Score = 58.9 bits (141), Expect = 1e-08
Identities = 31/129 (24%), Positives = 76/129 (58%), Gaps = 3/129 (2%)
Query: 184 EEQEKKRKEEEERRRREEEER---ERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
E++E+ +K+EE+ +EE+ R E++ ++EE+ +++EE+ ++EE+ R++ E+ R + E
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE 269
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Q ++Q L + + ++ +Q EQ++ + Q ++ Q+ + + Q+ +Q
Sbjct: 270 QMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQ 329
Query: 301 QAALQKQQE 309
+ + +Q+E
Sbjct: 330 EEQMWEQKE 338
Score = 55.8 bits (133), Expect = 9e-08
Identities = 41/134 (30%), Positives = 76/134 (56%), Gaps = 15/134 (11%)
Query: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE-----EERLRREEEERRRIEEER 236
+ ++QE++ E+EE+ R++EE+ ++EE+ +++EE EE++R++EE+ R EE+
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMG--EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271
Query: 237 LRLEQQ--KQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ 294
E+Q KQ+ QT Q +Q Q+ EQ + Q++EQ +Q +Q Q
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQE-----EQMREQEEQMREQE-EQMREQEEQ 325
Query: 295 VQLAQQQAALQKQQ 308
+ ++Q QK+Q
Sbjct: 326 MGKQEEQMWEQKEQ 339
Score = 53.1 bits (126), Expect = 6e-07
Identities = 35/129 (27%), Positives = 71/129 (55%), Gaps = 4/129 (3%)
Query: 185 EQEKKRKEEEERRRREEE---ERERLQKEEEKRRREEEERLRREEEERRRIEEE-RLRLE 240
EQE + +E+E + R +E E+E E+E++ E+EE+++++EE+ EE+ R + E
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Q +Q + VQ Q+ ++ +Q+ +R+ +EQ +Q Q + Q +Q
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 301 QAALQKQQE 309
+ +++Q+E
Sbjct: 295 EEQMREQEE 303
Score = 52.8 bits (125), Expect = 8e-07
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 4/129 (3%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQ 241
EQE + +E+E + R +E E+E E+E + E+EE++ +EE+ ++ EE+ E+
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 242 QKQQIMAALNSQ-TAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQ 300
Q ++ + Q VQ Q+ Q+ +Q+ +R+ +EQ +Q Q L Q + +Q
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ 287
Query: 301 QAALQKQQE 309
+ +Q+E
Sbjct: 288 EEQTGEQEE 296
Score = 52.4 bits (124), Expect = 1e-06
Identities = 36/125 (28%), Positives = 73/125 (58%), Gaps = 10/125 (8%)
Query: 185 EQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQ 244
EQE + E+EE+ +EE+ +QK+EE+ E+EE++R++EE+ EE+ + E+Q Q
Sbjct: 196 EQEGQMGEQEEQMGEQEEQ---MQKQEEQMG-EQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 245 QIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAAL 304
+ Q Q +Q Q+ +++Q+L ++ Q + +Q +Q + Q+ +Q+ +
Sbjct: 252 K----QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ--EEQMREQEEQM 305
Query: 305 QKQQE 309
++Q+E
Sbjct: 306 REQEE 310
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/131 (27%), Positives = 78/131 (59%), Gaps = 11/131 (8%)
Query: 182 EKEEQEKKRKE---EEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLR 238
E+EEQ +++E E+E + RE+EE+ R E+E++ RE+EE++ ++EE+ + E++ +
Sbjct: 286 EQEEQTGEQEEQMREQEEQMREQEEQMR---EQEEQMREQEEQMGKQEEQ---MWEQKEQ 339
Query: 239 LEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLA 298
+ +QK+Q M Q Q +Q Q+ +++Q + +Q ++ Q+ + + Q+
Sbjct: 340 MWEQKEQ-MWKQEEQMGEQEEQMQKQEEQVRKQEEQ-MRKQEEQMRKQEEQMRKQEEQMG 397
Query: 299 QQQAALQKQQE 309
+Q+ + +Q+E
Sbjct: 398 EQKEQMGEQKE 408
Score = 50.4 bits (119), Expect = 4e-06
Identities = 46/225 (20%), Positives = 106/225 (47%), Gaps = 18/225 (8%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEE 206
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
++ +Q++Q M Q Q +Q Q+ +++Q+ ++ Q Q ++ M++ + Q+
Sbjct: 207 QMGEQEEQ-MQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK-QEEQM 264
Query: 298 AQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEA 357
+Q+ +++Q+E ++ T + M + + +E E + E+
Sbjct: 265 REQEEQMREQEEQMLKQKE-QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 358 LENGPKESLPVIAAPSMWTR--------PQIKDFKEKIQQDADSV 394
+ G +E MW + Q+ + +E++Q+ + V
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQV 368
Score = 50.4 bits (119), Expect = 4e-06
Identities = 35/130 (26%), Positives = 74/130 (56%), Gaps = 16/130 (12%)
Query: 183 KEEQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
+E++E+ R++EE+ ++EE E++E++ +++E+ ++EE+ +EE+ +++ E+ R +
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE 372
Query: 240 EQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQ 299
EQ ++Q Q Q +Q Q+ EQ Q+ EQ Q Q + Q+ +
Sbjct: 373 EQMRKQ-----EEQMRKQEEQMRKQE-----EQMGEQKEQMGEQKEQMREQ---EEQMGE 419
Query: 300 QQAALQKQQE 309
Q+ ++KQ+E
Sbjct: 420 QKEQMRKQEE 429
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/131 (24%), Positives = 73/131 (55%), Gaps = 6/131 (4%)
Query: 184 EEQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
E++E+ R++EE+ R +EE E+ E+++++EE+ ++EE+ ++E+ + E+ + E
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE 352
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQ---HYQQYMQQLYQVQL 297
Q +Q + V+ Q+ ++ +Q+ +R+ +EQ +Q +Q Q++
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 298 AQQQAALQKQQ 308
++Q QK+Q
Sbjct: 413 QEEQMGEQKEQ 423
Score = 49.7 bits (117), Expect = 7e-06
Identities = 31/104 (29%), Positives = 64/104 (61%), Gaps = 11/104 (10%)
Query: 184 EEQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLE 240
E++E+ +++E+ ++EE E+ E++QK+EE+ R++EE+ +R++EE+ R+ EE+ + E
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ-MRKQEEQMRKQEEQMRKQE 393
Query: 241 QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
+Q M Q Q +Q Q+ +++Q+ + QE+H
Sbjct: 394 EQ----MGEQKEQMGEQKEQMREQEEQMGEQKEQM---RKQEEH 430
Score = 48.9 bits (115), Expect = 1e-05
Identities = 40/134 (29%), Positives = 70/134 (52%), Gaps = 16/134 (11%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
++ +Q+ Q M Q Q +Q Q+ EQ Q Q+ EQ Q Q + Q+
Sbjct: 186 QVREQEGQ-MGEQEGQMGEQEEQMGEQE-----EQMQKQEEQMGEQEEQMRKQ---EEQM 236
Query: 298 AQQQAALQKQQEVV 311
+Q+ +QKQ+E V
Sbjct: 237 GEQEEQVQKQEEQV 250
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/133 (26%), Positives = 73/133 (54%), Gaps = 11/133 (8%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 91 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 150
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQ-VQ 296
++ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q +Q Q Q Q
Sbjct: 151 QVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQ 207
Query: 297 LAQQQAALQKQQE 309
+ +Q+ +QKQ+E
Sbjct: 208 MGEQEEQMQKQEE 220
Score = 47.0 bits (110), Expect = 4e-05
Identities = 34/133 (25%), Positives = 74/133 (55%), Gaps = 11/133 (8%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQ-QLYQVQ 296
++ +Q+ Q+ + V+ Q+ ++ G +Q+ + + +EQ +Q Q Q + Q
Sbjct: 165 QVREQEGQVR---EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ 221
Query: 297 LAQQQAALQKQQE 309
+ +Q+ ++KQ+E
Sbjct: 222 MGEQEEQMRKQEE 234
Score = 43.9 bits (102), Expect = 4e-04
Identities = 16/63 (25%), Positives = 43/63 (68%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
++ K+E++ +++EE+ R++ E+ ++ Q E+K + E++ RE+EE+ ++E++R
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Query: 240 EQQ 242
+++
Sbjct: 427 QEE 429
Score = 42.7 bits (99), Expect = 8e-04
Identities = 32/132 (24%), Positives = 69/132 (52%), Gaps = 10/132 (7%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 56 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 115
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
++ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q +Q Q Q
Sbjct: 116 QVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 172
Query: 298 AQQQAALQKQQE 309
++Q ++QE
Sbjct: 173 VREQEGQVREQE 184
Score = 42.7 bits (99), Expect = 8e-04
Identities = 32/132 (24%), Positives = 69/132 (52%), Gaps = 10/132 (7%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 238 RLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQL 297
++ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q +Q Q Q
Sbjct: 123 QVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179
Query: 298 AQQQAALQKQQE 309
++Q ++QE
Sbjct: 180 VREQEGQVREQE 191
Score = 42.7 bits (99), Expect = 8e-04
Identities = 21/70 (30%), Positives = 51/70 (72%), Gaps = 8/70 (11%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREE---EERRRIEEER 236
+++K+E++ RK+EE+ R++EE+ ++K+EE+ R++EE+ ++E E++ ++ E+
Sbjct: 360 QMQKQEEQV-RKQEEQMRKQEEQ----MRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQE 414
Query: 237 LRLEQQKQQI 246
++ +QK+Q+
Sbjct: 415 EQMGEQKEQM 424
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/137 (24%), Positives = 72/137 (52%), Gaps = 12/137 (8%)
Query: 185 EQEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERL 237
EQE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 238 RLEQQKQQIM----AALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLY 293
++ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q +Q Q
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 294 QV-QLAQQQAALQKQQE 309
Q Q+ +Q+ + +Q+E
Sbjct: 190 QEGQMGEQEGQMGEQEE 206
Score = 40.8 bits (94), Expect = 0.003
Identities = 31/131 (23%), Positives = 68/131 (51%), Gaps = 10/131 (7%)
Query: 186 QEKKRKEEEERRRREE---EERERLQKEEEKRRREEEERLRREE----EERRRIEEERLR 238
QE + +E+E + R +E E+E +E+E + RE+E ++R +E E+ ++ E+ +
Sbjct: 50 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 109
Query: 239 LEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLA 298
+ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q +Q Q Q
Sbjct: 110 VREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 166
Query: 299 QQQAALQKQQE 309
++Q ++QE
Sbjct: 167 REQEGQVREQE 177
Score = 40.8 bits (94), Expect = 0.003
Identities = 16/58 (27%), Positives = 38/58 (65%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL 237
++ K+E++ +++EE+ R++ E+ ++ Q E+K + E+E E++E+ R +EE +
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 39.3 bits (90), Expect = 0.009
Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 18/145 (12%)
Query: 180 KIEKEEQEKKRKEE-------EERRRREEE----ERERLQKEEEKRRREEEERLRREE-- 226
+I+ +E KRK E +E + RE+E E+E +E+E + RE+E ++R +E
Sbjct: 29 EIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 88
Query: 227 --EERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQH 284
E+ ++ E+ ++ +Q+ Q+ + V+ Q+ ++ G +Q+ +R+ + Q
Sbjct: 89 VREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 145
Query: 285 YQQYMQQLYQVQLAQQQAALQKQQE 309
+Q Q Q ++Q ++QE
Sbjct: 146 REQEGQVREQEGQVREQEGQVREQE 170
Score = 37.7 bits (86), Expect = 0.026
Identities = 30/133 (22%), Positives = 66/133 (49%), Gaps = 3/133 (2%)
Query: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKE-EEKRRREEEERLRREEEERRRIEEERLR 238
+I EE ++K E +E + E E+ +Q +E +R+ E +++ +E + R +E ++R
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 239 LE--QQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQ 296
+ Q ++Q + V+ Q+ ++ G +Q+ +R+ + Q +Q Q Q
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 297 LAQQQAALQKQQE 309
++Q ++QE
Sbjct: 123 QVREQEGQVREQE 135
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,785,757
Number of Sequences: 37866
Number of extensions: 1447252
Number of successful extensions: 83692
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1659
Number of HSP's successfully gapped in prelim test: 1145
Number of HSP's that attempted gapping in prelim test: 20656
Number of HSP's gapped (non-prelim): 29940
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.