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Search of human proteins with 157739938
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157739938 dehydrogenase/reductase (SDR family) member 7C
[Homo sapiens]
(311 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 623 e-179
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 251 6e-67
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 113 2e-25
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 93 3e-19
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 86 5e-17
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 75 7e-14
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 75 7e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 75 7e-14
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 74 1e-13
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 74 1e-13
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 74 1e-13
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 73 3e-13
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 72 6e-13
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 72 6e-13
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 71 1e-12
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 68 9e-12
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 68 9e-12
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 67 3e-11
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 65 8e-11
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 65 1e-10
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 65 1e-10
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 65 1e-10
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 65 1e-10
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 65 1e-10
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 64 1e-10
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 64 2e-10
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 63 3e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 62 7e-10
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 62 7e-10
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 61 1e-09
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 623 bits (1607), Expect = e-179
Identities = 311/311 (100%), Positives = 311/311 (100%)
Query: 1 MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60
MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG
Sbjct: 1 MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60
Query: 61 GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV 120
GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV
Sbjct: 61 GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV 120
Query: 121 DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ 180
DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ
Sbjct: 121 DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ 180
Query: 181 GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASI 240
GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASI
Sbjct: 181 GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASI 240
Query: 241 WKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFFAVVACG 300
WKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFFAVVACG
Sbjct: 241 WKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFFAVVACG 300
Query: 301 VKEKLNVPEEG 311
VKEKLNVPEEG
Sbjct: 301 VKEKLNVPEEG 311
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 251 bits (641), Expect = 6e-67
Identities = 135/305 (44%), Positives = 197/305 (64%), Gaps = 7/305 (2%)
Query: 3 VMAMLMLPLLL--LGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60
+ + +LPLL LG+ GL + Q V K+ ++N VVVIT A SGLGKECA+VF+
Sbjct: 19 ITSTAILPLLFGCLGVFGLFRLLQWVR---GKAYLRNAVVVITGATSGLGKECAKVFYAA 75
Query: 61 GARLVLCGKNWERLENLYDALI-SVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGC 119
GA+LVLCG+N LE L L S A +T P LV DL+D + A E+L C+G
Sbjct: 76 GAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGY 135
Query: 120 VDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNI 179
VDIL+NNA + +G ++++DK++M+ NYFGP+ LTKALLP+MI RR G IV +++I
Sbjct: 136 VDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSI 195
Query: 180 QGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRSYHVYPEQGNWEAS 239
QGK IPFR+ YAASKHA FFDCLRAE+E+Y++ ++ +SP +I + ++ + S
Sbjct: 196 QGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT-NLSVNAITADGS 254
Query: 240 IWKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFFAVVAC 299
+ G PVEVA++V+ V +KK++V +A+ +P AVY+RT P FF+++A
Sbjct: 255 RYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMAS 314
Query: 300 GVKEK 304
+++
Sbjct: 315 RARKE 319
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 113 bits (283), Expect = 2e-25
Identities = 77/232 (33%), Positives = 125/232 (53%), Gaps = 13/232 (5%)
Query: 6 MLMLPLLLLGISGLLFIYQE--VSRLWSKSA-------VQNKVVVITDAISGLGKECARV 56
+++ LLLL + L F+ + ++ LW++ + + VV +T A SG+G+E A
Sbjct: 10 LVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQ 69
Query: 57 FHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVL-LDLSDISCVPDVAKEVLD 115
G LVL + LE + + + + LVL LDL+D K VL
Sbjct: 70 LSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDI--LVLPLDLTDTGSHEAATKAVLQ 127
Query: 116 CYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVL 175
+G +DIL+NN + + SL++ +K+++ NY G ++LTK +LP+MI R+ G+IV
Sbjct: 128 EFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVT 187
Query: 176 VNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEY-DVVISTVSPTFIRS 226
VN+I G +P Y ASKHA GFF+ LR E+ Y +++S + P ++S
Sbjct: 188 VNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQS 239
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 93.2 bits (230), Expect = 3e-19
Identities = 62/191 (32%), Positives = 98/191 (51%), Gaps = 10/191 (5%)
Query: 34 AVQNKVVVITDAISGLGKECA-RVFHTGGAR--LVLCGKNWERLENLYDALISVADPSKT 90
A + V+I+ SG+G E A ++ H R +V ++ + E L A + T
Sbjct: 2 AAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLT 61
Query: 91 FTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDAN 150
V D S C+ + EV D+L+NNA + + GP +SL + + D N
Sbjct: 62 VAQLDVCSDESVAQCLSCIQGEV-------DVLVNNAGMGLVGPLEGLSLAAMQNVFDTN 114
Query: 151 YFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVE 210
+FG + L KA+LP M RR G IV+++++ G G+ F YAASK A GFF+ L ++
Sbjct: 115 FFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLL 174
Query: 211 EYDVVISTVSP 221
++++ IS V P
Sbjct: 175 QFNIFISLVEP 185
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 85.5 bits (210), Expect = 5e-17
Identities = 68/223 (30%), Positives = 113/223 (50%), Gaps = 14/223 (6%)
Query: 6 MLMLPLLLLGISGLLFIYQEVSRLWSKS--AVQNKVVVITDAISGLGKECARVFHTGGAR 63
ML+L L ++ +L +Y VS L S A+ VV+T SG+GK A + GA
Sbjct: 1 MLLLAAAFL-VAFVLLLYM-VSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAF 58
Query: 64 LVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLS-----DISCVPDVAKEVLDCYG 118
+ L +N ++L + + K V+L +S D + V +V K+ + G
Sbjct: 59 ITLVARNEDKLLQAKKEI-----EMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLG 113
Query: 119 CVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNN 178
VD+L+N A + V G + + +++M NY G + ++A++ M RR G+IV V++
Sbjct: 114 PVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSS 173
Query: 179 IQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP 221
G+ G+ T Y+ASK A G + L+ EV+ Y+V I+ P
Sbjct: 174 QAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 75.1 bits (183), Expect = 7e-14
Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 11/222 (4%)
Query: 1 MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60
M M +LP+L L ++ + Y + + +Q K V++T A G+G+E A
Sbjct: 1 MAFMKKYLLPILGLFMA---YYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKM 57
Query: 61 GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV 120
GA +V+ ++ E L+ + + + S + + + D++ + G +
Sbjct: 58 GAHVVVTARSKETLQKVVSHCLELGAASAHY----IAGTMEDMTFAEQFVAQAGKLMGGL 113
Query: 121 DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ 180
D+LI N + +K M+ N+ + LT A LP M+ + G IV+V+++
Sbjct: 114 DMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLA 172
Query: 181 GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPT 222
GK P Y+ASK A GFF +R +EY V VS T
Sbjct: 173 GKVAYPMVAAYSASKFALDGFFSSIR---KEYSVSRVNVSIT 211
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 75.1 bits (183), Expect = 7e-14
Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 11/222 (4%)
Query: 1 MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60
M M +LP+L L ++ + Y + + +Q K V++T A G+G+E A
Sbjct: 1 MAFMKKYLLPILGLFMA---YYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKM 57
Query: 61 GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV 120
GA +V+ ++ E L+ + + + S + + + D++ + G +
Sbjct: 58 GAHVVVTARSKETLQKVVSHCLELGAASAHY----IAGTMEDMTFAEQFVAQAGKLMGGL 113
Query: 121 DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ 180
D+LI N + +K M+ N+ + LT A LP M+ + G IV+V+++
Sbjct: 114 DMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLA 172
Query: 181 GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPT 222
GK P Y+ASK A GFF +R +EY V VS T
Sbjct: 173 GKVAYPMVAAYSASKFALDGFFSSIR---KEYSVSRVNVSIT 211
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 75.1 bits (183), Expect = 7e-14
Identities = 81/308 (26%), Positives = 131/308 (42%), Gaps = 34/308 (11%)
Query: 6 MLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLV 65
+L+LPLL++ S F+ + + + +V ++V+IT A G+G+ A F ++LV
Sbjct: 8 LLLLPLLIV-CSLESFVKLFIPK--RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLV 64
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILIN 125
L N LE + TF ++D S+ + AK+V G V IL+N
Sbjct: 65 LWDINKHGLEETAAKCKGLGAKVHTF-----VVDCSNREDIYSSAKKVKAEIGDVSILVN 119
Query: 126 NASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185
NA V +K + N TKA LP M G IV V + G +
Sbjct: 120 NAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSV 179
Query: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVV---ISTVSPTFIRSYHVYPEQGNWEASIWK 242
PF Y +SK AA+GF L E+ + + + P F+ + + K
Sbjct: 180 PFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFI------------K 227
Query: 243 FFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRT---FFPEFFFAVVAC 299
L + P EV +M + +++ +F IP + ++ T PE F AV
Sbjct: 228 NPSTSLGPTLEPEEVVNRLMHGILTEQKMIF----IPSSIAFLTTLERILPERFLAV--- 280
Query: 300 GVKEKLNV 307
+K+K++V
Sbjct: 281 -LKQKISV 287
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 74.3 bits (181), Expect = 1e-13
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 17/227 (7%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA--VQNKVVVITDAISGLGKECARVFHTGG----ARLV 65
LLLG + + I + R ++ +A V +K V++T SG G A+ H+ G A +
Sbjct: 31 LLLGSTSFIPIGR---RTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVL-DCYGCVDILI 124
+ K + ++ L D+L S + T +L + ++ V ++ + L D + L+
Sbjct: 88 MKDKGHDGVKEL-DSLNS----DRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLV 142
Query: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184
NNA + G SLE K++ + N +G + +TK+ LP +I R G++V ++++ G+
Sbjct: 143 NNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP-TFIRSYHVY 230
P R+ Y +K F DCLR E+ V +S V P FI + +Y
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY 248
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 74.3 bits (181), Expect = 1e-13
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 17/227 (7%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA--VQNKVVVITDAISGLGKECARVFHTGG----ARLV 65
LLLG + + I + R ++ +A V +K V++T SG G A+ H+ G A +
Sbjct: 31 LLLGSTSFIPIGR---RTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVL-DCYGCVDILI 124
+ K + ++ L D+L S + T +L + ++ V ++ + L D + L+
Sbjct: 88 MKDKGHDGVKEL-DSLNS----DRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLV 142
Query: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184
NNA + G SLE K++ + N +G + +TK+ LP +I R G++V ++++ G+
Sbjct: 143 NNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP-TFIRSYHVY 230
P R+ Y +K F DCLR E+ V +S V P FI + +Y
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY 248
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 74.3 bits (181), Expect = 1e-13
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 17/227 (7%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA--VQNKVVVITDAISGLGKECARVFHTGG----ARLV 65
LLLG + + I + R ++ +A V +K V++T SG G A+ H+ G A +
Sbjct: 31 LLLGSTSFIPIGR---RTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVL-DCYGCVDILI 124
+ K + ++ L D+L S + T +L + ++ V ++ + L D + L+
Sbjct: 88 MKDKGHDGVKEL-DSLNS----DRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLV 142
Query: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184
NNA + G SLE K++ + N +G + +TK+ LP +I R G++V ++++ G+
Sbjct: 143 NNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP-TFIRSYHVY 230
P R+ Y +K F DCLR E+ V +S V P FI + +Y
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY 248
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 73.2 bits (178), Expect = 3e-13
Identities = 55/231 (23%), Positives = 102/231 (44%), Gaps = 3/231 (1%)
Query: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
+Q +V ++T +G+GK + G+ +V+ + ERL++ D L + P+K
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGP 154
+ ++ + V ++ K LD +G ++ L+NN + PA IS + +++ N G
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDV 214
+ KA+ + + G IV + + K G P A++ L E +
Sbjct: 136 FYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGI 194
Query: 215 VISTVSPTFIRSYHVYPEQGNWEASIWKFFFRKLTYGVHPVEVAEEVMRTV 265
I+ V+P I S G+W S ++ F+K+ + V EEV V
Sbjct: 195 RINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIP--AKRIGVPEEVSSVV 243
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 72.0 bits (175), Expect = 6e-13
Identities = 58/212 (27%), Positives = 100/212 (47%), Gaps = 10/212 (4%)
Query: 8 MLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLVLC 67
M LLL G+ L F Y + +++Q V++T A +G+G+E A + G+ LVL
Sbjct: 1 MKVLLLTGLGALFFAYYWDDN-FDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLT 59
Query: 68 GKNWERLENLYDALISVADPSKTFTPKL--VLLDLSDISCVPDVAKEVLDCYGCVDILIN 125
L+ + V + K PK+ + D++ V + LD G +D L+
Sbjct: 60 AHTEALLQKV------VGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVL 113
Query: 126 NASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185
N S + + +M N+ + LT LP++ + G +V+V+++ G+
Sbjct: 114 NHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPT 172
Query: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVVIS 217
F T Y+A+K A GFF LR E++ DV ++
Sbjct: 173 SFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 72.0 bits (175), Expect = 6e-13
Identities = 58/212 (27%), Positives = 100/212 (47%), Gaps = 10/212 (4%)
Query: 8 MLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLVLC 67
M LLL G+ L F Y + +++Q V++T A +G+G+E A + G+ LVL
Sbjct: 1 MKVLLLTGLGALFFAYYWDDN-FDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLT 59
Query: 68 GKNWERLENLYDALISVADPSKTFTPKL--VLLDLSDISCVPDVAKEVLDCYGCVDILIN 125
L+ + V + K PK+ + D++ V + LD G +D L+
Sbjct: 60 AHTEALLQKV------VGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVL 113
Query: 126 NASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185
N S + + +M N+ + LT LP++ + G +V+V+++ G+
Sbjct: 114 NHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPT 172
Query: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVVIS 217
F T Y+A+K A GFF LR E++ DV ++
Sbjct: 173 SFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 71.2 bits (173), Expect = 1e-12
Identities = 62/227 (27%), Positives = 107/227 (47%), Gaps = 13/227 (5%)
Query: 7 LMLPLLLLGISGLLFIYQEVSRLW---SKSAVQNKVVVITDAISGLGKECARVFHTGGAR 63
++L +LLL I+ + + + + + + +V ++V+IT A G+G++ F +
Sbjct: 3 IILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSI 62
Query: 64 LVLCGKNWERLENLYDALISVADPSKT-FTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI 122
LVL N +E + A+ K T ++D S+ + +V G V I
Sbjct: 63 LVLWDINKRGVEE------TAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTI 116
Query: 123 LINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
++NNA E K + N G +TKALLP+M+ R G IV V ++ G
Sbjct: 117 VVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGH 176
Query: 183 FGIPFRTTYAASKHAALGFFDCLRAEVE---EYDVVISTVSPTFIRS 226
GIP+ Y +SK AA+GF L +E++ + + S + P F+ +
Sbjct: 177 EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNT 223
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 68.2 bits (165), Expect = 9e-12
Identities = 62/249 (24%), Positives = 113/249 (45%), Gaps = 22/249 (8%)
Query: 39 VVVITDAISGLGKECARVFHTGGA---RLVLCGKNWERLENLYDALISVADPSKTFTPKL 95
VV+IT SG+G A + + ++ ++ + L++A ++A P + +
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL--ET 62
Query: 96 VLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPI 155
+ LD+ D V + V + G VD+L+ NA + + GP + + ++D N G +
Sbjct: 63 LQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV 120
Query: 156 TLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVV 215
+ +A LP+M R +G++++ ++ G G+PF Y ASK A G + L + + V
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
Query: 216 IS-----TVSPTFIRSYHVYPEQGNWEASIWKF--FFRKLTY--------GVHPVEVAEE 260
+S V F+ PE+ I F F++ L + +P EVAE
Sbjct: 181 LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV 240
Query: 261 VMRTVRRKK 269
+ +R K
Sbjct: 241 FLTALRAPK 249
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 68.2 bits (165), Expect = 9e-12
Identities = 62/221 (28%), Positives = 107/221 (48%), Gaps = 22/221 (9%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLV---LCG 68
+ +G+ LL Y+E L S +++K V IT SG GK AR G R++ L
Sbjct: 7 VFVGLYYLLHWYRERQVL---SHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTE 63
Query: 69 KNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--LINN 126
K E+L +D +T T LD++ V A+ V +C + L+NN
Sbjct: 64 KGAEQLRG------QTSDRLETVT-----LDVTKTESVAAAAQWVKECVRDKGLWGLVNN 112
Query: 127 ASVKVKGPAHKISLELD-KKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185
A + + +++ + D I+D N G I +T +LLP ++ R G++V V+++ G+ +
Sbjct: 113 AGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL 171
Query: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
F Y SK+ F D LR E+ + V ++ + P + ++
Sbjct: 172 -FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKT 211
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 66.6 bits (161), Expect = 3e-11
Identities = 59/195 (30%), Positives = 88/195 (45%), Gaps = 7/195 (3%)
Query: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
V ++V+IT A SGLG+ A F G+ LVL W+ + + +A +
Sbjct: 38 VAGEIVLITGAGSGLGRLLALQFARLGSVLVL----WDINKEGNEETCKMAREAGATRVH 93
Query: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGP 154
D S V VA +V G V ILINNA + EL +K D N+
Sbjct: 94 AYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAH 153
Query: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEV---EE 211
+ KA LP MI+ G +V +++ G G+ Y ASK AA GF + + E ++
Sbjct: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
Query: 212 YDVVISTVSPTFIRS 226
+ + V P FI++
Sbjct: 214 KGIKTTIVCPFFIKT 228
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 65.1 bits (157), Expect = 8e-11
Identities = 49/185 (26%), Positives = 83/185 (44%), Gaps = 11/185 (5%)
Query: 38 KVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVL 97
KVVV+T G+G R F GAR+V+C K+ L L P F +L
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL-----PGAVF----IL 60
Query: 98 LDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGP-AHKISLELDKKIMDANYFGPIT 156
D++ V + E + +G +D ++NNA + S + +++++ N G T
Sbjct: 61 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
Query: 157 LTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVI 216
LTK LP + + G ++ ++++ G G Y A+K A L + Y V +
Sbjct: 121 LTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRV 179
Query: 217 STVSP 221
+ +SP
Sbjct: 180 NCISP 184
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 64.7 bits (156), Expect = 1e-10
Identities = 49/201 (24%), Positives = 98/201 (48%), Gaps = 6/201 (2%)
Query: 27 SRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVAD 86
S + + + NKV ++T + G+G AR GA +V+ + + +N+ A+ ++
Sbjct: 22 SGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSR---KQQNVDQAVATLQG 78
Query: 87 PSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVK-VKGPAHKISLELDKK 145
+ T + + ++ + + +G +DIL++NA+V G ++ E+ K
Sbjct: 79 EGLSVTGTVCHVGKAEDR--ERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDK 136
Query: 146 IMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCL 205
+D N P +TKA++P M R G +V+V++I P + Y SK A LG L
Sbjct: 137 TLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTL 196
Query: 206 RAEVEEYDVVISTVSPTFIRS 226
E+ ++ ++ ++P I++
Sbjct: 197 AIELAPRNIRVNCLAPGLIKT 217
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 64.7 bits (156), Expect = 1e-10
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65
+L + GLL + LW++ + +K + IT SG G AR F G ++
Sbjct: 1 MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123
E+ AL A+ S+ + VLLD++D V A+ V + G + L
Sbjct: 58 AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
Query: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
INNA V V P ++LE ++ ++ N FG I++T +LP ++ + G+++ V+++ G+
Sbjct: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
Query: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
I Y SK+A GF D LR +++ + V +S + P ++
Sbjct: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 64.7 bits (156), Expect = 1e-10
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65
+L + GLL + LW++ + +K + IT SG G AR F G ++
Sbjct: 1 MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123
E+ AL A+ S+ + VLLD++D V A+ V + G + L
Sbjct: 58 AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
Query: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
INNA V V P ++LE ++ ++ N FG I++T +LP ++ + G+++ V+++ G+
Sbjct: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
Query: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
I Y SK+A GF D LR +++ + V +S + P ++
Sbjct: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 64.7 bits (156), Expect = 1e-10
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65
+L + GLL + LW++ + +K + IT SG G AR F G ++
Sbjct: 1 MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123
E+ AL A+ S+ + VLLD++D V A+ V + G + L
Sbjct: 58 AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
Query: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
INNA V V P ++LE ++ ++ N FG I++T +LP ++ + G+++ V+++ G+
Sbjct: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
Query: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
I Y SK+A GF D LR +++ + V +S + P ++
Sbjct: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 64.7 bits (156), Expect = 1e-10
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)
Query: 12 LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65
+L + GLL + LW++ + +K + IT SG G AR F G ++
Sbjct: 1 MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
Query: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123
E+ AL A+ S+ + VLLD++D V A+ V + G + L
Sbjct: 58 AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
Query: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
INNA V V P ++LE ++ ++ N FG I++T +LP ++ + G+++ V+++ G+
Sbjct: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
Query: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
I Y SK+A GF D LR +++ + V +S + P ++
Sbjct: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 64.3 bits (155), Expect = 1e-10
Identities = 64/205 (31%), Positives = 92/205 (44%), Gaps = 14/205 (6%)
Query: 32 KSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTF 91
K V ++V+ T A SGLG++ A F GA LVL N E N+ ++ K
Sbjct: 31 KKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEG--NMETCRLAKEKGGKKV 88
Query: 92 TPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANY 151
P D S+ V VA +V +G V IL+NNA + P I + +K N
Sbjct: 89 FP--YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
Query: 152 FGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIP-------FRTTYAASKHAALGFFDC 204
KA LP +I G +V +++I G GI Y+ASK AA GF +
Sbjct: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
Query: 205 LRAE---VEEYDVVISTVSPTFIRS 226
L E +++ +V + V P FI +
Sbjct: 207 LFFELTMIKKTEVKSTIVCPHFINT 231
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 10/139 (7%)
Query: 91 FTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDAN 150
F + +L L DI+ V KEV G V I++NNA E K + N
Sbjct: 56 FAKRQSILVLWDIN---KVKKEV----GDVTIVVNNAGTVYPADLLSTKDEEITKTFEVN 108
Query: 151 YFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVE 210
G +TKALLP+M+ R G IV V ++ G GIP+ Y +SK AA+GF L +E++
Sbjct: 109 ILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQ 168
Query: 211 ---EYDVVISTVSPTFIRS 226
+ + S + P F+ +
Sbjct: 169 ALGKTGIKTSCLCPVFVNT 187
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 63.2 bits (152), Expect = 3e-10
Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 17/218 (7%)
Query: 32 KSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDAL----ISVADP 87
K + N+V V+T + SG+G AR GA +V+ + + ++ L +SVA
Sbjct: 31 KGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG- 89
Query: 88 SKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVK-VKGPAHKISLELDKKI 146
++ + + + L+ G VD L+ +A V + G S ++ KI
Sbjct: 90 --------IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKI 141
Query: 147 MDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLR 206
+ N P L LLP M +RR G ++LV++I + Y SK A LG L
Sbjct: 142 LSVNVKSPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLA 200
Query: 207 AEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASIWKFF 244
E+ D+ ++ V P I++ GN S+WK F
Sbjct: 201 LELAPKDIRVNCVVPGIIKTDFSKVFHGN--ESLWKNF 236
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 62.0 bits (149), Expect = 7e-10
Identities = 51/195 (26%), Positives = 91/195 (46%), Gaps = 12/195 (6%)
Query: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
V KV ++T A G+G+ A GA++ L N E AL +P KT
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTL--- 59
Query: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELD-KKIMDANYFG 153
+ D++D + D ++V+D +G +DIL+NNA V + K +L+++ ++ Y G
Sbjct: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEK-TLQINLVSVISGTYLG 118
Query: 154 PITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGF--FDCLRAEVEE 211
++K G I+ ++++ G + + Y ASKH +GF L A +
Sbjct: 119 LDYMSK-----QNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN 173
Query: 212 YDVVISTVSPTFIRS 226
V ++ + P F+ +
Sbjct: 174 SGVRLNAICPGFVNT 188
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 62.0 bits (149), Expect = 7e-10
Identities = 53/171 (30%), Positives = 80/171 (46%), Gaps = 14/171 (8%)
Query: 40 VVITDAISGLGKECARVFHTGGAR-LVLCGKNWERLENLYDALISVADPSKTFTPKLVLL 98
V+IT G+G++ AR F GAR +VL G+ + L+ + + + F +
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYF-----IC 95
Query: 99 DLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDK----KIMDANYFGP 154
D+ + V AK V + G + IL+NNA+V V G K ++ D K N G
Sbjct: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHG---KSLMDSDDDALLKSQHINTLGQ 151
Query: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCL 205
TKA LP M+ + G IV +N++ IP Y SK +A F + L
Sbjct: 152 FWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 61.2 bits (147), Expect = 1e-09
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 10/188 (5%)
Query: 41 VITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDL 100
V+T + G+GK A G ++VL ++ ++L+ + + + K T + + +D
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSS---EIKEKFKVET-RTIAVDF 109
Query: 101 SDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISL-ELD---KKIMDANYFGPIT 156
+ + + + IL+NN + + P + + + +LD KK+++ N
Sbjct: 110 ASEDIYDKIKTGLAGLE--IGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
Query: 157 LTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVI 216
+T+ +LP M+ R G I+ +++ G +P T Y+A+K F CL E V +
Sbjct: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
Query: 217 STVSPTFI 224
+V P F+
Sbjct: 228 QSVLPYFV 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,860,953
Number of Sequences: 37866
Number of extensions: 422631
Number of successful extensions: 1151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 1042
Number of HSP's gapped (non-prelim): 81
length of query: 311
length of database: 18,247,518
effective HSP length: 102
effective length of query: 209
effective length of database: 14,385,186
effective search space: 3006503874
effective search space used: 3006503874
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.