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Search of human proteins with 157738687
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738687 WEE1 homolog 2 [Homo sapiens]
(567 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738687 WEE1 homolog 2 [Homo sapiens] 1140 0.0
gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens] 434 e-121
gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens] 422 e-118
gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens] 135 1e-31
gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens] 135 1e-31
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 90 5e-18
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 90 5e-18
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 89 8e-18
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 84 3e-16
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 83 8e-16
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 83 8e-16
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 83 8e-16
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 83 8e-16
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 82 1e-15
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 82 1e-15
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 82 1e-15
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 82 1e-15
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 81 2e-15
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 81 2e-15
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 81 3e-15
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 80 5e-15
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 80 5e-15
gi|145275208 myosin IIIA [Homo sapiens] 80 5e-15
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 80 5e-15
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 78 2e-14
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 78 2e-14
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 78 2e-14
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 78 2e-14
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 78 2e-14
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 76 9e-14
>gi|157738687 WEE1 homolog 2 [Homo sapiens]
Length = 567
Score = 1140 bits (2950), Expect = 0.0
Identities = 567/567 (100%), Positives = 567/567 (100%)
Query: 1 MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKGEVQDSEAKGTPPWTPL 60
MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKGEVQDSEAKGTPPWTPL
Sbjct: 1 MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKGEVQDSEAKGTPPWTPL 60
Query: 61 SNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRSKLLPSDSPSTPKTMLSRL 120
SNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRSKLLPSDSPSTPKTMLSRL
Sbjct: 61 SNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRSKLLPSDSPSTPKTMLSRL 120
Query: 121 VISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDL 180
VISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDL
Sbjct: 121 VISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDL 180
Query: 181 EEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAI 240
EEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAI
Sbjct: 181 EEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAI 240
Query: 241 KRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAA 300
KRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAA
Sbjct: 241 KRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAA 300
Query: 301 ISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIE 360
ISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIE
Sbjct: 301 ISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIE 360
Query: 361 EVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFAL 420
EVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFAL
Sbjct: 361 EVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFAL 420
Query: 421 GLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 480
GLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL
Sbjct: 421 GLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 480
Query: 481 ARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTG 540
ARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTG
Sbjct: 481 ARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTG 540
Query: 541 SRSTKRLVGGKSARSSSFTSGEREPLH 567
SRSTKRLVGGKSARSSSFTSGEREPLH
Sbjct: 541 SRSTKRLVGGKSARSSSFTSGEREPLH 567
>gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens]
Length = 646
Score = 434 bits (1116), Expect = e-121
Identities = 246/484 (50%), Positives = 316/484 (65%), Gaps = 23/484 (4%)
Query: 92 PETPAQPDSRS--KLLPSDSPSTPKTMLSRLVISPTGKLPSRGPKHLKLTPAPLKDE--M 147
P+ P P ++ KL D+P TPK++LS+ + + RG T K E +
Sbjct: 168 PDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDV 227
Query: 148 TSLALVNINPFTPESYKKLFLQSGGKRKIRG----------DLEEAGPEEGKGGLPAKRC 197
VNINPFTP+S L L S G+ + R D+E + E PAKR
Sbjct: 228 RQTPQVNINPFTPDS---LLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRI 284
Query: 198 VLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSAL 257
+ E+NM SRY EF E+EKIG GEFG+V+KC+KRLDGC+YAIKRS K +E +AL
Sbjct: 285 TITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNAL 344
Query: 258 HEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLK 317
EVYAHAVLG H HVVRY+S+WAEDDHM+IQNEYCNGGSL AISEN + ++F+E +LK
Sbjct: 345 REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELK 404
Query: 318 DILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYK 377
D+LLQ+ GL YIH+ S+VH+DIKPSNIFI ++ E +E DW S VM+K
Sbjct: 405 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFI---SRTSIPNAASEEGDEDDW-ASNKVMFK 460
Query: 378 IGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNG 437
IGDLGH T I+ P+VEEGDSRFLANE+LQE+Y HLPKADIFAL LT+ AAGAE LP NG
Sbjct: 461 IGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNG 520
Query: 438 AAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT-EEL 496
WH IR+G P +PQ LS+ F+ LLK MI PD E+RPSA AL +++VL + K+ E+L
Sbjct: 521 DQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQL 580
Query: 497 QQQLNLEKFKTATLERELREAQQAQ-SPQGYTHHGDTGVSGTHTGSRSTKRLVGGKSARS 555
+ +LN EKFK + L++EL++AQ A+ + + D + + T S T RL+G K RS
Sbjct: 581 RIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRS 640
Query: 556 SSFT 559
S T
Sbjct: 641 VSLT 644
>gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]
Length = 432
Score = 422 bits (1084), Expect = e-118
Identities = 229/419 (54%), Positives = 289/419 (68%), Gaps = 19/419 (4%)
Query: 153 VNINPFTPESYKKLFLQSGGKRKIRG----------DLEEAGPEEGKGGLPAKRCVLRET 202
VNINPFTP+S L L S G+ + R D+E + E PAKR + E+
Sbjct: 19 VNINPFTPDS---LLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITES 75
Query: 203 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 262
NM SRY EF E+EKIG GEFG+V+KC+KRLDGC+YAIKRS K +E +AL EVYA
Sbjct: 76 NMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA 135
Query: 263 HAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQ 322
HAVLG H HVVRY+S+WAEDDHM+IQNEYCNGGSL AISEN + ++F+E +LKD+LLQ
Sbjct: 136 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQ 195
Query: 323 ISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLG 382
+ GL YIH+ S+VH+DIKPSNIFI ++ E +E DW S VM+KIGDLG
Sbjct: 196 VGRGLRYIHSMSLVHMDIKPSNIFI---SRTSIPNAASEEGDEDDW-ASNKVMFKIGDLG 251
Query: 383 HATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH 442
H T I+ P+VEEGDSRFLANE+LQE+Y HLPKADIFAL LT+ AAGAE LP NG WH
Sbjct: 252 HVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHE 311
Query: 443 IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT-EELQQQLN 501
IR+G P +PQ LS+ F+ LLK MI PD E+RPSA AL +++VL + K+ E+L+ +LN
Sbjct: 312 IRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELN 371
Query: 502 LEKFKTATLERELREAQQAQ-SPQGYTHHGDTGVSGTHTGSRSTKRLVGGKSARSSSFT 559
EKFK + L++EL++AQ A+ + + D + + T S T RL+G K RS S T
Sbjct: 372 AEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLT 430
>gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens]
Length = 480
Score = 135 bits (339), Expect = 1e-31
Identities = 94/286 (32%), Positives = 136/286 (47%), Gaps = 33/286 (11%)
Query: 206 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAV 265
S +++ F + ++G G +G V+K + DG +YA+KRSM F + L EV +H
Sbjct: 104 SFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEK 163
Query: 266 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 325
+G HP VR +W E + +Q E C G SLQ G E ++ L L
Sbjct: 164 VGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQ---QHCEAWGASLPEAQVWGYLRDTLL 219
Query: 326 GLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHAT 385
L ++H+ +VHLD+KP+NI FL K+GD G
Sbjct: 220 ALAHLHSQGLVHLDVKPANI-----------------------FLGPRGRCKLGDFGLLV 256
Query: 386 SINKP---KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH 442
+ +V+EGD R++A E+LQ Y AD+F+LGLTI A LP G W
Sbjct: 257 ELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPHGGEGWQQ 314
Query: 443 IRKGNF-PDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 487
+R+G P+ LS S+L M++PD + R +A AL VLR
Sbjct: 315 LRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
>gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens]
Length = 499
Score = 135 bits (339), Expect = 1e-31
Identities = 94/286 (32%), Positives = 136/286 (47%), Gaps = 33/286 (11%)
Query: 206 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAV 265
S +++ F + ++G G +G V+K + DG +YA+KRSM F + L EV +H
Sbjct: 104 SFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEK 163
Query: 266 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 325
+G HP VR +W E + +Q E C G SLQ G E ++ L L
Sbjct: 164 VGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQ---QHCEAWGASLPEAQVWGYLRDTLL 219
Query: 326 GLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHAT 385
L ++H+ +VHLD+KP+NI FL K+GD G
Sbjct: 220 ALAHLHSQGLVHLDVKPANI-----------------------FLGPRGRCKLGDFGLLV 256
Query: 386 SINKP---KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH 442
+ +V+EGD R++A E+LQ Y AD+F+LGLTI A LP G W
Sbjct: 257 ELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPHGGEGWQQ 314
Query: 443 IRKGNF-PDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 487
+R+G P+ LS S+L M++PD + R +A AL VLR
Sbjct: 315 LRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 90.1 bits (222), Expect = 5e-18
Identities = 82/336 (24%), Positives = 148/336 (44%), Gaps = 61/336 (18%)
Query: 215 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVR 274
+E IG G +G VYK + DG + A+K + +++ E A + + L +HP+VV+
Sbjct: 30 IETIGKGTYGKVYKVTNKRDGSLAAVK-ILDPVSDMDEEIEAEYNILQF--LPNHPNVVK 86
Query: 275 YYSSWAEDDHMI-----IQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 329
+Y + + DH + + E CNGGS+ + + G +E + IL LGL +
Sbjct: 87 FYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQH 146
Query: 330 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 389
+HN+ ++H D+K +NI + + GV K+ D G + +
Sbjct: 147 LHNNRIIHRDVKGNNILL-----TTEGGV------------------KLVDFGVSAQLTS 183
Query: 390 PKVEE----GDSRFLANEIL----QEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWH 441
++ G ++A E++ Q D + + D+++LG+T A+ G P H
Sbjct: 184 TRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGIT-AIELGDGDPPL--FDMH 240
Query: 442 HIR-----KGNFPDV---PQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT 493
++ N P P++ E F+ + + D E+RPS L + ++ GK
Sbjct: 241 PVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKV 300
Query: 494 EELQQQLNLEKFKTATLERELREAQQAQSPQGYTHH 529
LQ+QL ++ + Q+ Q+P T H
Sbjct: 301 LFLQKQL-----------AKVLQDQKHQNPVAKTRH 325
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 90.1 bits (222), Expect = 5e-18
Identities = 82/336 (24%), Positives = 148/336 (44%), Gaps = 61/336 (18%)
Query: 215 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVR 274
+E IG G +G VYK + DG + A+K + +++ E A + + L +HP+VV+
Sbjct: 30 IETIGKGTYGKVYKVTNKRDGSLAAVK-ILDPVSDMDEEIEAEYNILQF--LPNHPNVVK 86
Query: 275 YYSSWAEDDHMI-----IQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 329
+Y + + DH + + E CNGGS+ + + G +E + IL LGL +
Sbjct: 87 FYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQH 146
Query: 330 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 389
+HN+ ++H D+K +NI + + GV K+ D G + +
Sbjct: 147 LHNNRIIHRDVKGNNILL-----TTEGGV------------------KLVDFGVSAQLTS 183
Query: 390 PKVEE----GDSRFLANEIL----QEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWH 441
++ G ++A E++ Q D + + D+++LG+T A+ G P H
Sbjct: 184 TRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGIT-AIELGDGDPPL--FDMH 240
Query: 442 HIR-----KGNFPDV---PQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT 493
++ N P P++ E F+ + + D E+RPS L + ++ GK
Sbjct: 241 PVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKV 300
Query: 494 EELQQQLNLEKFKTATLERELREAQQAQSPQGYTHH 529
LQ+QL ++ + Q+ Q+P T H
Sbjct: 301 LFLQKQL-----------AKVLQDQKHQNPVAKTRH 325
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 89.4 bits (220), Expect = 8e-18
Identities = 82/312 (26%), Positives = 136/312 (43%), Gaps = 40/312 (12%)
Query: 210 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH- 268
++++ ++KIG G FG DG Y IK + + EV AVL +
Sbjct: 2 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREV---AVLANM 58
Query: 269 -HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGL 327
HP++V+Y S+ E+ + I +YC GG L I N + G F+E ++ D +QI L L
Sbjct: 59 KHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRI--NAQKGVLFQEDQILDWFVQICLAL 116
Query: 328 NYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 387
++H+ ++H DIK NI FL+ + ++GD G A +
Sbjct: 117 KHVHDRKILHRDIKSQNI-----------------------FLTKDGTVQLGDFGIARVL 153
Query: 388 NK----PKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHI 443
N + G +L+ EI E+ + K+DI+ALG + + G+ + +
Sbjct: 154 NSTVELARTCIGTPYYLSPEIC-ENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLV 212
Query: 444 RK---GNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQL 500
K G+FP V S SL+ + + + RPS ++ + + K L QL
Sbjct: 213 LKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKF--LSPQL 270
Query: 501 NLEKFKTATLER 512
E+F T +
Sbjct: 271 IAEEFCLKTFSK 282
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 84.3 bits (207), Expect = 3e-16
Identities = 88/348 (25%), Positives = 152/348 (43%), Gaps = 64/348 (18%)
Query: 199 LRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR--SMKTFTELSNENSA 256
L E ++ + E+ F +EK+G G +G+VYK I + G + AIK+ E+ E S
Sbjct: 17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISI 76
Query: 257 LHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKL 316
+ + PHVV+YY S+ ++ + I EYC GS+ I K+ E ++
Sbjct: 77 MQQC-------DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT---LTEDEI 126
Query: 317 KDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMY 376
IL GL Y+H +H DIK NI + E A
Sbjct: 127 ATILQSTLKGLEYLHFMRKIHRDIKAGNILL-------------NTEGHA---------- 163
Query: 377 KIGDLGHATSIN----KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLT-IAVAAGAE 431
K+ D G A + K G ++A E++QE + ADI++LG+T I +A G
Sbjct: 164 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNCVADIWSLGITAIEMAEGKP 222
Query: 432 ------------SLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA 479
+PTN RK P+ S++F+ +K + EQR +A
Sbjct: 223 PYADIHPMRAIFMIPTNPPP--TFRK------PELWSDNFTDFVKQCLVKSPEQRATATQ 274
Query: 480 LARNTVLRPSLGKT---EELQQQLNLEKFKTATLERELREAQQAQSPQ 524
L ++ +R + G + + + + ++++ + + +RE+ + + S +
Sbjct: 275 LLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEE 322
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 82.8 bits (203), Expect = 8e-16
Identities = 73/315 (23%), Positives = 129/315 (40%), Gaps = 45/315 (14%)
Query: 218 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYS 277
+G G +G V R DG Y IK+ +A E + L HP++V Y
Sbjct: 12 VGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL-KHPNIVTYKE 70
Query: 278 SWAEDDHMI-IQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMV 336
SW D ++ I +C GG L + E + G E ++ + +QI++ L Y+H ++
Sbjct: 71 SWEGGDGLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYLHEKHIL 128
Query: 337 HLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK----PKV 392
H D+K N+F L+ + K+GDLG A +
Sbjct: 129 HRDLKTQNVF-----------------------LTRTNIIKVGDLGIARVLENHCDMAST 165
Query: 393 EEGDSRFLANEILQ-EDYRHLPKADIFALGLTI---AVAAGAESLPTNGAAWHHIRKGNF 448
G +++ E+ + Y + K+D++ALG + A A + + + I +G
Sbjct: 166 LIGTPYYMSPELFSNKPYNY--KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKL 223
Query: 449 PDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLEKFKTA 508
P +P++ S + L++ M+ E+RPS ++ R ++ Q LE K
Sbjct: 224 PPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIK--------RQISFFLEATKIK 275
Query: 509 TLERELREAQQAQSP 523
T + ++ P
Sbjct: 276 TSKNNIKNGDSQSKP 290
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 82.8 bits (203), Expect = 8e-16
Identities = 76/288 (26%), Positives = 125/288 (43%), Gaps = 42/288 (14%)
Query: 211 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK--RSMKTFTELSNENSALHEVYAHAVLGH 268
+++ + IG G FG ++A+K R K+F SN ++ E A +
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSF---SNTQNSRKEAVLLAKM-K 58
Query: 269 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 328
HP++V + S+ + H+ I EYC+GG L I + + G F E + + Q+ LG+N
Sbjct: 59 HPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 329 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 388
+IH ++H DIK NI FL+ N K+GD G A ++
Sbjct: 117 HIHKKRVLHRDIKSKNI-----------------------FLTQNGKVKLGDFGSARLLS 153
Query: 389 KPK----VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH-- 442
P G ++ EI E+ + K+DI++LG + + P +W +
Sbjct: 154 NPMAFACTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTLKH-PFQANSWKNLI 211
Query: 443 --IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA-LARNTVLR 487
+ +G +P S L+K M + + RPSA L+R V R
Sbjct: 212 LKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVAR 259
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 82.8 bits (203), Expect = 8e-16
Identities = 76/288 (26%), Positives = 125/288 (43%), Gaps = 42/288 (14%)
Query: 211 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK--RSMKTFTELSNENSALHEVYAHAVLGH 268
+++ + IG G FG ++A+K R K+F SN ++ E A +
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSF---SNTQNSRKEAVLLAKM-K 58
Query: 269 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 328
HP++V + S+ + H+ I EYC+GG L I + + G F E + + Q+ LG+N
Sbjct: 59 HPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 329 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 388
+IH ++H DIK NI FL+ N K+GD G A ++
Sbjct: 117 HIHKKRVLHRDIKSKNI-----------------------FLTQNGKVKLGDFGSARLLS 153
Query: 389 KPK----VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH-- 442
P G ++ EI E+ + K+DI++LG + + P +W +
Sbjct: 154 NPMAFACTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTLKH-PFQANSWKNLI 211
Query: 443 --IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA-LARNTVLR 487
+ +G +P S L+K M + + RPSA L+R V R
Sbjct: 212 LKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVAR 259
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 82.8 bits (203), Expect = 8e-16
Identities = 76/288 (26%), Positives = 125/288 (43%), Gaps = 42/288 (14%)
Query: 211 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK--RSMKTFTELSNENSALHEVYAHAVLGH 268
+++ + IG G FG ++A+K R K+F SN ++ E A +
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSF---SNTQNSRKEAVLLAKM-K 58
Query: 269 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 328
HP++V + S+ + H+ I EYC+GG L I + + G F E + + Q+ LG+N
Sbjct: 59 HPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 329 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 388
+IH ++H DIK NI FL+ N K+GD G A ++
Sbjct: 117 HIHKKRVLHRDIKSKNI-----------------------FLTQNGKVKLGDFGSARLLS 153
Query: 389 KPK----VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH-- 442
P G ++ EI E+ + K+DI++LG + + P +W +
Sbjct: 154 NPMAFACTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTLKH-PFQANSWKNLI 211
Query: 443 --IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA-LARNTVLR 487
+ +G +P S L+K M + + RPSA L+R V R
Sbjct: 212 LKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVAR 259
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 82.4 bits (202), Expect = 1e-15
Identities = 79/312 (25%), Positives = 137/312 (43%), Gaps = 42/312 (13%)
Query: 202 TNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVY 261
TN+ + E+ F ++EKIG G FG V+K I V AIK + E +E + +
Sbjct: 26 TNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIK--IIDLEEAEDEIEDIQQEI 83
Query: 262 AHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILL 321
P+V +YY S+ +D + I EY GGS + +E ++ IL
Sbjct: 84 TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDETQIATILR 138
Query: 322 QISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDL 381
+I GL+Y+H+ +H DIK +N+ LS + K+ D
Sbjct: 139 EILKGLDYLHSEKKIHRDIKAANV-----------------------LLSEHGEVKLADF 175
Query: 382 GHATSINKPKVEE----GDSRFLANEILQEDYRHLPKADIFALGLT-IAVAAG----AES 432
G A + +++ G ++A E++++ + KADI++LG+T I +A G +E
Sbjct: 176 GVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEPPHSEL 234
Query: 433 LPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGK 492
P I K N P + S+ ++ + + RP+A L ++ + + K
Sbjct: 235 HPMK--VLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKK 292
Query: 493 TEELQQQLNLEK 504
T L + ++ K
Sbjct: 293 TSYLTELIDRYK 304
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 82.0 bits (201), Expect = 1e-15
Identities = 81/336 (24%), Positives = 145/336 (43%), Gaps = 64/336 (19%)
Query: 194 AKRCVLRETNMASRYEK-----EFLEVEKIGVGEFGTVY----KCIKRLDGCVYAIKRSM 244
A +CV T + S Y K ++ +K+G G FGTVY K KR + +
Sbjct: 7 AAKCVSGSTAI-STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGE--------EL 57
Query: 245 KTFTELS----NENSALHEVYAHAVLGH--HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQ 298
K E+S N N + +L HP +V++++S+ E D+ I EYC G L
Sbjct: 58 KVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLD 117
Query: 299 AAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGV 358
I E ++G F E ++ + +Q+ LG++Y+H ++H D+K N+F+
Sbjct: 118 DKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL----------- 166
Query: 359 IEEVENEADWFLSANVMYKIGDLGHAT----SINKPKVEEGDSRFLANEILQEDYRHLPK 414
N + KIGD G + S + G +++ E L+ + K
Sbjct: 167 -------------KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ-GYDTK 212
Query: 415 ADIFALGLTI-------AVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMI 467
+DI++L + AG+ L + I +G+ P +P+ + ++++++M+
Sbjct: 213 SDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVEGDTPSLPERYPKELNAIMESML 268
Query: 468 QPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLE 503
+ RPSA + + L L ++ LE
Sbjct: 269 NKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLE 304
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 82.0 bits (201), Expect = 1e-15
Identities = 81/336 (24%), Positives = 145/336 (43%), Gaps = 64/336 (19%)
Query: 194 AKRCVLRETNMASRYEK-----EFLEVEKIGVGEFGTVY----KCIKRLDGCVYAIKRSM 244
A +CV T + S Y K ++ +K+G G FGTVY K KR + +
Sbjct: 7 AAKCVSGSTAI-STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGE--------EL 57
Query: 245 KTFTELS----NENSALHEVYAHAVLGH--HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQ 298
K E+S N N + +L HP +V++++S+ E D+ I EYC G L
Sbjct: 58 KVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLD 117
Query: 299 AAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGV 358
I E ++G F E ++ + +Q+ LG++Y+H ++H D+K N+F+
Sbjct: 118 DKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL----------- 166
Query: 359 IEEVENEADWFLSANVMYKIGDLGHAT----SINKPKVEEGDSRFLANEILQEDYRHLPK 414
N + KIGD G + S + G +++ E L+ + K
Sbjct: 167 -------------KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ-GYDTK 212
Query: 415 ADIFALGLTI-------AVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMI 467
+DI++L + AG+ L + I +G+ P +P+ + ++++++M+
Sbjct: 213 SDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVEGDTPSLPERYPKELNAIMESML 268
Query: 468 QPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLE 503
+ RPSA + + L L ++ LE
Sbjct: 269 NKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLE 304
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 82.0 bits (201), Expect = 1e-15
Identities = 81/336 (24%), Positives = 145/336 (43%), Gaps = 64/336 (19%)
Query: 194 AKRCVLRETNMASRYEK-----EFLEVEKIGVGEFGTVY----KCIKRLDGCVYAIKRSM 244
A +CV T + S Y K ++ +K+G G FGTVY K KR + +
Sbjct: 7 AAKCVSGSTAI-STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGE--------EL 57
Query: 245 KTFTELS----NENSALHEVYAHAVLGH--HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQ 298
K E+S N N + +L HP +V++++S+ E D+ I EYC G L
Sbjct: 58 KVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLD 117
Query: 299 AAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGV 358
I E ++G F E ++ + +Q+ LG++Y+H ++H D+K N+F+
Sbjct: 118 DKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL----------- 166
Query: 359 IEEVENEADWFLSANVMYKIGDLGHAT----SINKPKVEEGDSRFLANEILQEDYRHLPK 414
N + KIGD G + S + G +++ E L+ + K
Sbjct: 167 -------------KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ-GYDTK 212
Query: 415 ADIFALGLTI-------AVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMI 467
+DI++L + AG+ L + I +G+ P +P+ + ++++++M+
Sbjct: 213 SDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVEGDTPSLPERYPKELNAIMESML 268
Query: 468 QPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLE 503
+ RPSA + + L L ++ LE
Sbjct: 269 NKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLE 304
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 81.3 bits (199), Expect = 2e-15
Identities = 79/308 (25%), Positives = 137/308 (44%), Gaps = 46/308 (14%)
Query: 209 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 268
E+ F ++E+IG G FG V+K I V AIK + E +E + +
Sbjct: 21 EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIK--IIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 269 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 328
+V +YY S+ + + I EY GGS + F+E ++ +L +I GL+
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGP-----FDEFQIATMLKEILKGLD 133
Query: 329 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 388
Y+H+ +H DIK +N+ + SE V K+ D G A +
Sbjct: 134 YLHSEKKIHRDIKAANVLL-----SEQGDV------------------KLADFGVAGQLT 170
Query: 389 KPKVEE----GDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIR 444
+++ G ++A E++Q+ + KADI++LG+T A E P N + H +R
Sbjct: 171 DTQIKRNTFVGTPFWMAPEVIQQS-AYDSKADIWSLGITAIELAKGE--PPN-SDMHPMR 226
Query: 445 ------KGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQ 498
K N P + + ++SF + + D RP+A L ++ + + KT L +
Sbjct: 227 VLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTE 286
Query: 499 QLNLEKFK 506
+++FK
Sbjct: 287 L--IDRFK 292
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 81.3 bits (199), Expect = 2e-15
Identities = 71/272 (26%), Positives = 123/272 (45%), Gaps = 38/272 (13%)
Query: 216 EKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHHPHVVR 274
+KIG G+F VY+ LDG A+K+ + + + E+ L +HP+V++
Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NHPNVIK 96
Query: 275 YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSS 334
YY+S+ ED+ + I E + G L I K E + +Q+ L ++H+
Sbjct: 97 YYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
Query: 335 MVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEE 394
++H DIKP+N+FI ++GV+ K+GDLG +
Sbjct: 157 VMHRDIKPANVFI------TATGVV-----------------KLGDLGLGRFFSSKTTAA 193
Query: 395 ----GDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNG------AAWHHIR 444
G +++ E + E+ + K+DI++LG + A +S P G + I
Sbjct: 194 HSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQS-PFYGDKMNLYSLCKKIE 251
Query: 445 KGNFPDVPQE-LSESFSSLLKNMIQPDAEQRP 475
+ ++P +P + SE L+ I PD E+RP
Sbjct: 252 QCDYPPLPSDHYSEELRQLVNMCINPDPEKRP 283
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 80.9 bits (198), Expect = 3e-15
Identities = 81/325 (24%), Positives = 141/325 (43%), Gaps = 48/325 (14%)
Query: 189 KGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFT 248
+ GLP + N+ + E+ F ++EKIG G FG V+K I V AIK +
Sbjct: 7 QSGLPGMQ------NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIK--IIDLE 58
Query: 249 ELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSG 308
E +E + + P+V +YY S+ +D + I EY GGS +
Sbjct: 59 EAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP--- 115
Query: 309 NHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADW 368
+E ++ IL +I GL+Y+H+ +H DIK +N+
Sbjct: 116 --LDETQIATILREILKGLDYLHSEKKIHRDIKAANV----------------------- 150
Query: 369 FLSANVMYKIGDLGHATSINKPKVEE----GDSRFLANEILQEDYRHLPKADIFALGLT- 423
LS + K+ D G A + +++ G ++A E++++ + KADI++LG+T
Sbjct: 151 LLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADIWSLGITA 209
Query: 424 IAVAAG----AESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA 479
I +A G +E P I K N P + S+ ++ + + RP+A
Sbjct: 210 IELARGEPPHSELHPMK--VLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKE 267
Query: 480 LARNTVLRPSLGKTEELQQQLNLEK 504
L ++ + + KT L + ++ K
Sbjct: 268 LLKHKFILRNAKKTSYLTELIDRYK 292
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 80.1 bits (196), Expect = 5e-15
Identities = 74/326 (22%), Positives = 139/326 (42%), Gaps = 58/326 (17%)
Query: 230 IKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQN 289
IKR++ +++ + EL E A+ + HHP++V YY+S+ D + +
Sbjct: 45 IKRIN-----LEKCQTSMDELLKEIQAMSQC-------HHPNIVSYYTSFVVKDELWLVM 92
Query: 290 EYCNGGSLQAAISENTKSGNH----FEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNI 345
+ +GGS+ I G H +E + IL ++ GL Y+H + +H D+K NI
Sbjct: 93 KLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNI 152
Query: 346 FICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEIL 405
+ G ++ + FL+ G T K G ++A E++
Sbjct: 153 LL------GEDGSVQIADFGVSAFLATG--------GDITRNKVRKTFVGTPCWMAPEVM 198
Query: 406 QEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH--------IRKGNFP-------- 449
++ + KADI++ G+T A L T A +H + N P
Sbjct: 199 EQVRGYDFKADIWSFGIT------AIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ 252
Query: 450 --DVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLEKFKT 507
++ ++ +SF ++ +Q D E+RP+AA L R+ + + K +E Q+ L+ +
Sbjct: 253 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA--KNKEFLQEKTLQ--RA 308
Query: 508 ATLERELREAQQAQSPQGYTHHGDTG 533
T+ ++ ++ G H + G
Sbjct: 309 PTISERAKKVRRVPGSSGRLHKTEDG 334
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 80.1 bits (196), Expect = 5e-15
Identities = 96/379 (25%), Positives = 160/379 (42%), Gaps = 71/379 (18%)
Query: 199 LRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR--SMKTFTELSNENSA 256
L E ++ + E+ F +EK+G G +G+V+K I + G V AIK+ E+ E S
Sbjct: 14 LSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISI 73
Query: 257 LHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKL 316
+ + P+VV+YY S+ ++ + I EYC GS+ I K+ E ++
Sbjct: 74 MQQC-------DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT---LIEDEI 123
Query: 317 KDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMY 376
IL GL Y+H +H DIK NI + E A
Sbjct: 124 ATILKSTLKGLEYLHFMRKIHRDIKAGNILL-------------NTEGHA---------- 160
Query: 377 KIGDLGHATSIN----KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLT-IAVAAGAE 431
K+ D G A + K G ++A E++QE + ADI++LG+T I +A G
Sbjct: 161 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNCVADIWSLGITSIEMAEGKP 219
Query: 432 ------------SLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA 479
+PTN RK P+ S+ F+ +K + + EQR +A
Sbjct: 220 PYADIHPMRAIFMIPTNPPP--TFRK------PELWSDDFTDFVKKCLVKNPEQRATATQ 271
Query: 480 LARNTVLRPSLGKTEELQQQLNLE--KFKTATLERELREAQQAQSPQGYTHHGDTGVSGT 537
L ++ ++ + K + + L E + K E + RE ++ + + D +
Sbjct: 272 LLQHPFIKNA--KPVSILRDLITEAMEIKAKRHEEQQRELEEEE------ENSDEDELDS 323
Query: 538 HTGSRSTKRLVGGKSARSS 556
HT +++ VG A S+
Sbjct: 324 HTMVKTSVESVGTMRATST 342
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 80.1 bits (196), Expect = 5e-15
Identities = 74/300 (24%), Positives = 136/300 (45%), Gaps = 38/300 (12%)
Query: 216 EKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRY 275
E IG G +G V+K + + +G A+K + ++ E A + + L HP+VVR+
Sbjct: 25 ETIGKGTYGKVFKVLNKKNGQKAAVK-ILDPIHDIDEEIEAEYNILK--ALSDHPNVVRF 81
Query: 276 YSSW-----AEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 330
Y + D + + E C+GGS+ + K G EP + IL + +GL ++
Sbjct: 82 YGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHL 141
Query: 331 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 390
HN+ +H D+K +NI + + G ++ V D+ +SA + ++ ++
Sbjct: 142 HNNKTIHRDVKGNNILL------TTEGGVKLV----DFGVSAQL---------TSTRHRR 182
Query: 391 KVEEGDSRFLANEIL----QEDYRHLPKADIFALGLTIAVAAGAESLPTNG----AAWHH 442
G ++A E++ Q D + + D ++LG+T A+ G P A
Sbjct: 183 NTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGIT-AIELGDGDPPLADLHPMRALFK 241
Query: 443 IRKGNFPDV--PQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQL 500
I + P + P+ S F+ + + D E+RP+ + L ++ + GK LQ+QL
Sbjct: 242 IPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQL 301
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 80.1 bits (196), Expect = 5e-15
Identities = 77/296 (26%), Positives = 128/296 (43%), Gaps = 39/296 (13%)
Query: 215 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVR 274
++ IG G FG Y + D IK + + ++ EV + HP++V
Sbjct: 7 IKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKM-KHPNIVA 65
Query: 275 YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSS 334
+++S+ E+ + I EYC+GG L I N + G F E ++ +QISLGL +IH+
Sbjct: 66 FFNSFQENGRLFIVMEYCDGGDLMKRI--NRQRGVLFSEDQILGWFVQISLGLKHIHDRK 123
Query: 335 MVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK----P 390
++H DIK NIF+ +G++ K+GD G A +N
Sbjct: 124 ILHRDIKAQNIFL------SKNGMVA----------------KLGDFGIARVLNNSMELA 161
Query: 391 KVEEGDSRFLANEILQ-EDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH----IRK 445
+ G +L+ EI Q + Y + K DI++LG + + P G I +
Sbjct: 162 RTCIGTPYYLSPEICQNKPYNN--KTDIWSLGCVLYELCTLKH-PFEGNNLQQLVLKICQ 218
Query: 446 GNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGK--TEELQQQ 499
+F + S SL+ + Q RPS ++ + L + K T E+ Q+
Sbjct: 219 AHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 78.2 bits (191), Expect = 2e-14
Identities = 71/276 (25%), Positives = 122/276 (44%), Gaps = 40/276 (14%)
Query: 210 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 269
+++ + +G G FG V+ C+++ D + IK+ +A +E +L +H
Sbjct: 2 EKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLL-NH 60
Query: 270 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 329
P+V+ YY ++ ED ++I EY GG+L I + S EE + +QI L L++
Sbjct: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNS--LLEEETILHFFVQILLALHH 118
Query: 330 IHNSSMVHLDIKPSNIFI-CHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA---T 385
+H ++H D+K NI + H+M + KIGD G + +
Sbjct: 119 VHTHLILHRDLKTQNILLDKHRM-----------------------VVKIGDFGISKILS 155
Query: 386 SINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAG------AESLPTNGAA 439
S +K G +++ E L E + K+DI+ALG + A A +LP A
Sbjct: 156 SKSKAYTVVGTPCYISPE-LCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLP---AL 211
Query: 440 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRP 475
I G F + S L+ +++ + QRP
Sbjct: 212 VLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRP 247
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 78.2 bits (191), Expect = 2e-14
Identities = 86/344 (25%), Positives = 145/344 (42%), Gaps = 49/344 (14%)
Query: 203 NMASRYEKE--FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEV 260
N SR + E F ++++IG G FG VYK I V AIK + E +E + +
Sbjct: 9 NQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIK--IIDLEEAEDEIEDIQQE 66
Query: 261 YAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDIL 320
P++ RY+ S+ + + I EY GGS + EE + IL
Sbjct: 67 ITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATIL 121
Query: 321 LQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGD 380
+I GL+Y+H+ +H DIK +N+ + SE V K+ D
Sbjct: 122 REILKGLDYLHSERKIHRDIKAANVLL-----SEQGDV------------------KLAD 158
Query: 381 LGHATSINKPKVEE----GDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTN 436
G A + +++ G ++A E++++ KADI++LG+T A E P N
Sbjct: 159 FGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIWSLGITAIELAKGE--PPN 215
Query: 437 GAAWHHIR------KGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSL 490
+ H +R K + P + + S+ F ++ + D RP+A L ++ +
Sbjct: 216 -SDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYT 274
Query: 491 GKTEELQQQLNLEKFKTATLERELREAQQAQSP-QGYTHHGDTG 533
KT L + ++++K E E+ S G G+ G
Sbjct: 275 KKTSFLTEL--IDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQG 316
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/289 (24%), Positives = 127/289 (43%), Gaps = 52/289 (17%)
Query: 217 KIGVGEFGTVYKCIKRLDGCVYAIKR------SMKTFTELSNENSALHEVYAHAVLGHHP 270
KIG G++G VY CI G + A+K KT E ++E + HP
Sbjct: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI-------KHP 1400
Query: 271 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 330
++VRY+ + M I EYC+ G+L+ E ++ G +E ++ QI++ +N +
Sbjct: 1401 NLVRYFGVELHREEMYIFMEYCDEGTLE----EVSRLG--LQEHVIRLYSKQITIAINVL 1454
Query: 331 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 390
H +VH DIK +NIF+ SSG+I+ + L N G++
Sbjct: 1455 HEHGIVHRDIKGANIFL------TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTL----- 1503
Query: 391 KVEEGDSRFLANEIL--QEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH------ 442
G + ++A E++ + H ADI++LG + + T WH
Sbjct: 1504 ----GTAAYMAPEVITRAKGEGHGRAADIWSLGCVVI------EMVTGKRPWHEYEHNFQ 1553
Query: 443 ----IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 487
+ G+ P +P+ LS L + ++ D + R +A+ L ++ ++
Sbjct: 1554 IMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVK 1602
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/289 (24%), Positives = 127/289 (43%), Gaps = 52/289 (17%)
Query: 217 KIGVGEFGTVYKCIKRLDGCVYAIKR------SMKTFTELSNENSALHEVYAHAVLGHHP 270
KIG G++G VY CI G + A+K KT E ++E + HP
Sbjct: 1298 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI-------KHP 1350
Query: 271 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 330
++VRY+ + M I EYC+ G+L+ E ++ G +E ++ QI++ +N +
Sbjct: 1351 NLVRYFGVELHREEMYIFMEYCDEGTLE----EVSRLG--LQEHVIRLYSKQITIAINVL 1404
Query: 331 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 390
H +VH DIK +NIF+ SSG+I+ + L N G++
Sbjct: 1405 HEHGIVHRDIKGANIFL------TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTL----- 1453
Query: 391 KVEEGDSRFLANEIL--QEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH------ 442
G + ++A E++ + H ADI++LG + + T WH
Sbjct: 1454 ----GTAAYMAPEVITRAKGEGHGRAADIWSLGCVVI------EMVTGKRPWHEYEHNFQ 1503
Query: 443 ----IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 487
+ G+ P +P+ LS L + ++ D + R +A+ L ++ ++
Sbjct: 1504 IMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVK 1552
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 77.8 bits (190), Expect = 2e-14
Identities = 97/420 (23%), Positives = 161/420 (38%), Gaps = 67/420 (15%)
Query: 123 SPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDLEE 182
SP S+ P + TP+ S + +P +P S++ L + + G+
Sbjct: 308 SPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSS------- 360
Query: 183 AGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEK------IGVGEFGTVYKCIKRLDGC 236
GG RC+ E +R + +EK IG G F V +CI R G
Sbjct: 361 ---SNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGK 417
Query: 237 VYAIKRSMKTFT-----ELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEY 291
+A+K K + NE S L V HP+++ + + E
Sbjct: 418 EFALKIIDKAKCCGKEHLIENEVSILRRV-------KHPNIIMLVEEMETATELFLVMEL 470
Query: 292 CNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKM 351
GG L AI+ +TK + E ++ ++ L Y+H S+VH DIKP N+ +C
Sbjct: 471 VKGGDLFDAITSSTK----YTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYP 526
Query: 352 QSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEE-GDSRFLANEILQEDYR 410
S K+GD G AT + P G ++A EI+ E
Sbjct: 527 DGTKS-------------------LKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGY 567
Query: 411 HLPKADIFALG-LTIAVAAGAESLPTNGAAWHHI------RKGNFP-DVPQELSESFSSL 462
L K DI+A G +T + G + + K FP +++S L
Sbjct: 568 GL-KVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
Query: 463 LKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQS 522
+ M+Q + E R +A + + + +++ Q+ N++ T L++ A Q+
Sbjct: 627 ISQMLQVNVEARCTAGQILSHPWV------SDDASQENNMQAEVTGKLKQHFNNALPKQN 680
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 75.9 bits (185), Expect = 9e-14
Identities = 83/339 (24%), Positives = 144/339 (42%), Gaps = 63/339 (18%)
Query: 204 MASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTE-----LSNENSAL 257
M SR E ++ + IG G +G K ++ DG + K + TE L +E + L
Sbjct: 1 MPSRAE-DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLL 59
Query: 258 HEVYAHAVLGHHPHVVRYYSSWAEDDH--MIIQNEYCNGGSLQAAISENTKSGNHFEEPK 315
E+ HP++VRYY + + + I EYC GG L + I++ TK + +E
Sbjct: 60 REL-------KHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEF 112
Query: 316 LKDILLQISLGLNYIHNSS-----MVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFL 370
+ ++ Q++L L H S ++H D+KP+N+F+ K
Sbjct: 113 VLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQN------------------ 154
Query: 371 SANVMYKIGDLGHATSINK----PKVEEGDSRFLANEILQEDYRHLPKADIFALGLTI-- 424
K+GD G A +N K G +++ E + + K+DI++LG +
Sbjct: 155 -----VKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNR-MSYNEKSDIWSLGCLLYE 208
Query: 425 --AVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALAR 482
A+ + A IR+G F +P S+ + ++ M+ RPS +
Sbjct: 209 LCALMPPFTAFSQKELA-GKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILE 267
Query: 483 NTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQ 521
N P + +Q+ NLE+ R+L E +++Q
Sbjct: 268 N----PLIADLVADEQRRNLER-----RGRQLGEPEKSQ 297
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,149,001
Number of Sequences: 37866
Number of extensions: 1161447
Number of successful extensions: 5701
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 388
Number of HSP's successfully gapped in prelim test: 461
Number of HSP's that attempted gapping in prelim test: 4392
Number of HSP's gapped (non-prelim): 1174
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.