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Search of human proteins with 157671953
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157671953 solute carrier family 4, anion exchanger, member 3
isoform 2 [Homo sapiens]
(1259 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157671953 solute carrier family 4, anion exchanger, member 3 ... 2524 0.0
gi|157671951 solute carrier family 4, anion exchanger, member 3 ... 2452 0.0
gi|156071474 solute carrier family 4, anion exchanger, member 2 ... 1355 0.0
gi|4507021 solute carrier family 4, anion exchanger, member 1 [H... 954 0.0
gi|155722998 solute carrier family 4, sodium bicarbonate transpo... 657 0.0
gi|197927160 solute carrier family 4, sodium bicarbonate cotrans... 647 0.0
gi|4507025 solute carrier family 4, sodium bicarbonate cotranspo... 647 0.0
gi|148596928 solute carrier family 4, sodium bicarbonate cotrans... 647 0.0
gi|90403614 solute carrier family 4, sodium bicarbonate cotransp... 643 0.0
gi|90568034 solute carrier family 4, sodium bicarbonate cotransp... 643 0.0
gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sap... 606 e-173
gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sa... 598 e-170
gi|134288865 solute carrier family 4, sodium bicarbonate cotrans... 561 e-159
gi|151101449 solute carrier family 4, sodium bicarbonate cotrans... 557 e-158
gi|14042960 solute carrier family 4 member 11 [Homo sapiens] 253 1e-66
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 52 3e-06
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 52 3e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 51 6e-06
gi|239757043 PREDICTED: functional smad suppressing element 18 [... 50 1e-05
gi|239751555 PREDICTED: functional smad suppressing element 18 [... 50 1e-05
gi|239746067 PREDICTED: functional smad suppressing element 18 [... 50 1e-05
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 49 4e-05
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 48 5e-05
gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo ... 47 1e-04
gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo ... 47 1e-04
gi|239744803 PREDICTED: hypothetical protein XP_002343287 [Homo ... 47 1e-04
gi|55741677 SET domain containing 1A [Homo sapiens] 46 3e-04
gi|226371735 iroquois homeobox 3 [Homo sapiens] 46 3e-04
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 45 3e-04
gi|145275189 specifically androgen-regulated protein isoform 1 [... 45 4e-04
>gi|157671953 solute carrier family 4, anion exchanger, member 3
isoform 2 [Homo sapiens]
Length = 1259
Score = 2524 bits (6541), Expect = 0.0
Identities = 1259/1259 (100%), Positives = 1259/1259 (100%)
Query: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
Sbjct: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
Query: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
Sbjct: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
Query: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG
Sbjct: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
Query: 181 RAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARAS 240
RAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARAS
Sbjct: 181 RAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARAS 240
Query: 241 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 300
RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR
Sbjct: 241 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 300
Query: 301 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 360
LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS
Sbjct: 301 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 360
Query: 361 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 420
QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP
Sbjct: 361 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 420
Query: 421 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 480
GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH
Sbjct: 421 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 480
Query: 481 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 540
HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA
Sbjct: 481 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 540
Query: 541 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 600
EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR
Sbjct: 541 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 600
Query: 601 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660
SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL
Sbjct: 601 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660
Query: 661 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 720
RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY
Sbjct: 661 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 720
Query: 721 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 780
PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL
Sbjct: 721 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 780
Query: 781 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 840
FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS
Sbjct: 781 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 840
Query: 841 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 900
FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN
Sbjct: 841 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 900
Query: 901 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960
GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP
Sbjct: 901 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960
Query: 961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 1020
ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA
Sbjct: 961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 1020
Query: 1021 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1080
LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS
Sbjct: 1021 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1080
Query: 1081 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1140
VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI
Sbjct: 1081 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1140
Query: 1141 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1200
FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK
Sbjct: 1141 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1200
Query: 1201 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1259
STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
Sbjct: 1201 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1259
>gi|157671951 solute carrier family 4, anion exchanger, member 3
isoform 1 [Homo sapiens]
Length = 1232
Score = 2452 bits (6355), Expect = 0.0
Identities = 1232/1259 (97%), Positives = 1232/1259 (97%), Gaps = 27/1259 (2%)
Query: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
Sbjct: 1 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE 60
Query: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
Sbjct: 61 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS 120
Query: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG
Sbjct: 121 EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPG 180
Query: 181 RAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARAS 240
RAAVTKPLPSVGPHTDKSPQHSS SSPSPRARAS
Sbjct: 181 RAAVTKPLPSVGPHTDKSPQHSS---------------------------SSPSPRARAS 213
Query: 241 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 300
RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR
Sbjct: 214 RLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHR 273
Query: 301 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 360
LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS
Sbjct: 274 LEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 333
Query: 361 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 420
QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP
Sbjct: 334 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 393
Query: 421 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 480
GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH
Sbjct: 394 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 453
Query: 481 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 540
HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA
Sbjct: 454 HPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDA 513
Query: 541 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 600
EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR
Sbjct: 514 EATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGR 573
Query: 601 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660
SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL
Sbjct: 574 SIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 633
Query: 661 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 720
RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY
Sbjct: 634 RKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRY 693
Query: 721 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 780
PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL
Sbjct: 694 PHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVL 753
Query: 781 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 840
FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS
Sbjct: 754 FSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGS 813
Query: 841 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 900
FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN
Sbjct: 814 FLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPN 873
Query: 901 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960
GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP
Sbjct: 874 GSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 933
Query: 961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 1020
ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA
Sbjct: 934 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPA 993
Query: 1021 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1080
LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS
Sbjct: 994 LLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRS 1053
Query: 1081 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1140
VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI
Sbjct: 1054 VTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGI 1113
Query: 1141 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1200
FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK
Sbjct: 1114 FLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVK 1173
Query: 1201 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1259
STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
Sbjct: 1174 STAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV 1232
>gi|156071474 solute carrier family 4, anion exchanger, member 2
(erythrocyte membrane protein band 3-like 1) [Homo
sapiens]
Length = 1241
Score = 1355 bits (3508), Expect = 0.0
Identities = 738/1247 (59%), Positives = 894/1247 (71%), Gaps = 56/1247 (4%)
Query: 32 EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91
E+E+D+L +TL V RF +++ + + E+P RSY E DFE+HR +SHH HHPLS LPP
Sbjct: 32 EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91
Query: 92 PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151
+ R+ P R RR+ A P+ TP I+E EE+E+E E E
Sbjct: 92 DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139
Query: 152 PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRD 211
+P P TP +F + D D + R + + P P PH + +P+ S +
Sbjct: 140 LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQA---- 192
Query: 212 GDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNP 271
GT + + ++ AS K++P SY+L+ER GS G
Sbjct: 193 --GTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH--RSYNLQERRRIGSMTGAE 248
Query: 272 GGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGL 328
+VPTDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++ TQ GR G G
Sbjct: 249 QALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGP 308
Query: 329 APILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKP 388
P + + + +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKP
Sbjct: 309 TP-----RARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKP 363
Query: 389 HVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTL 448
HVASLSFRSLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR L
Sbjct: 364 HVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRAL 423
Query: 449 LLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWP 507
LLKHSHP+D+KD F PRN S+ S+ S+LG+HH + P P M G P
Sbjct: 424 LLKHSHPSDEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLE 479
Query: 508 HDPDAKEKPLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLN 564
+ + + P P G R KS LKLLEKIPE+AEATVVLVGCV FL +P AFVRL
Sbjct: 480 VERERELPPPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLR 538
Query: 565 EAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDL 624
EAV L++VLEVPVPVRFLF++LGPS + DYHE+GRSI+TLMSDK FHEAAY AD+R+DL
Sbjct: 539 EAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDL 598
Query: 625 LSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGK 684
L+AI+ FLD S+V+PPSEV+G +LLRSVA FQR++L+KR E+ + +A K
Sbjct: 599 LTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDK 658
Query: 685 ELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYF 744
L L++ + EDDPL RTG FGGL+RDVRRRYPHY SD RDAL QC+AAV+FIYF
Sbjct: 659 AL-LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717
Query: 745 AALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEA 804
AALSPAITFGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEA
Sbjct: 718 AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEA 777
Query: 805 FFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIY 864
FF FC + LEYL GRVW+G WLV L +VA EGSFLVR++S FTQEIFAFLISLIFIY
Sbjct: 778 FFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIY 837
Query: 865 ETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------P 913
ETFYKL K+F EHPL + + +D G + PT GP + P
Sbjct: 838 ETFYKLVKIFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKP 894
Query: 914 RNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSI 973
R QPNTALLSL+LM GTFFIAFFLRKF+NSRF G+ RR+IGDFG+PI+IL+MVLVDYSI
Sbjct: 895 RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954
Query: 974 TDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQI 1033
DTYTQKL+VP+G SVT+P+KR W I PLG PFP WMMVA+ +PA+LV ILIFMETQI
Sbjct: 955 EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014
Query: 1034 TALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTA 1093
T LI+S+K R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM A
Sbjct: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074
Query: 1094 IAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQ 1153
+APGDKP+IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ
Sbjct: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134
Query: 1154 LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLL 1213
+RL L+LMP KHHP+ YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+
Sbjct: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194
Query: 1214 LTVPLRHCLLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1259
LTVPLR +L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV
Sbjct: 1195 LTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241
>gi|4507021 solute carrier family 4, anion exchanger, member 1 [Homo
sapiens]
Length = 911
Score = 954 bits (2466), Expect = 0.0
Identities = 512/918 (55%), Positives = 642/918 (69%), Gaps = 65/918 (7%)
Query: 346 HEVFVELNELMLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
H+V+VEL EL++D ++QE W E ARW++ EE++ E WG+PH++ L+F SLLELRR
Sbjct: 55 HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRV 113
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 464
G LLDL++T+L G+A+ +++ I DQIRP+DR +LR LLLKHSH + + G
Sbjct: 114 FTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALG-- 171
Query: 465 PRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPA-PLWPHDPDAKEKPLHMPGGD 523
G P + G+P+ PL P + + G
Sbjct: 172 -------------------------GVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDG 206
Query: 524 GHRGKSLK-LLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFL 582
G G S +LEKIP D+EAT+VLVG FLEQP FVRL EA LE+V E+PVP+RFL
Sbjct: 207 GTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFL 265
Query: 583 FVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSE 642
FV+LGP DY +LGR+ ATLMS+++F AY A R +LL ++ FLD S+V+PP++
Sbjct: 266 FVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTD 325
Query: 643 VEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPL 702
L S+ QRELLR+R + K + + G L+L G DDPL
Sbjct: 326 APSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKG---------LDLNGGP----DDPL 372
Query: 703 LRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTE 762
+TG +FGGLVRD+RRRYP+Y SD+ DA Q +AAV+FIYFAALSPAITFGGLLGEKT
Sbjct: 373 QQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTR 432
Query: 763 GLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVW 822
MGVSEL++STAV G+LF+LLGAQPLLVVGFSGPLLVFEEAFF FC LEY+ GRVW
Sbjct: 433 NQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVW 492
Query: 823 VGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPF 882
+G WL++ V+ +VA EGSFLVR+IS +TQEIF+FLISLIFIYETF KL K+F +HPL
Sbjct: 493 IGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKT 552
Query: 883 YPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRN 942
Y N +P +GP PNTALLSL+LM GTFF A LRKF+N
Sbjct: 553 Y--------------NYNVLMVPKPQGP-----LPNTALLSLVLMAGTFFFAMMLRKFKN 593
Query: 943 SRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPL 1002
S + GK RR+IGDFG+PISIL+MVLVD+ I DTYTQKL+VP G V++ R W I PL
Sbjct: 594 SSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPL 653
Query: 1003 GSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLG 1062
G FP WMM A+A+PALLV ILIF+E+QIT LIVS+ R+++KGSGFHLDLLL+ +G
Sbjct: 654 GLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMG 713
Query: 1063 GLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLS 1122
G+ LFG+PWL+A TVRSVTH NALTVM A PG QIQEV+EQR++G+L+A LVGLS
Sbjct: 714 GVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLS 773
Query: 1123 IVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRM 1182
I+M +L RIPLAVLFGIFLYMGVTSLSGIQL R+LL+ P K+HP+ PYV +VKTWRM
Sbjct: 774 ILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRM 833
Query: 1183 HLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEP 1242
HLFT IQ+ C+A+LWVVKST ASLA PF+L+LTVPLR LLP +F++ ELQ LD++DA+
Sbjct: 834 HLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKA 893
Query: 1243 NFD-EDGQDEYNELHMPV 1259
FD E+G+DEY+E+ MPV
Sbjct: 894 TFDEEEGRDEYDEVAMPV 911
>gi|155722998 solute carrier family 4, sodium bicarbonate
transporter-like, member 10 [Homo sapiens]
Length = 1088
Score = 657 bits (1696), Expect = 0.0
Identities = 396/984 (40%), Positives = 562/984 (57%), Gaps = 73/984 (7%)
Query: 293 LDDMKSHRLEDNPGVRRHLVKKPSRTQG---GRGSPSGLAPILRRK----KKKKKLDRRP 345
L KSHR + G +H + R G GR SPS P R + + + P
Sbjct: 56 LGGRKSHRRHRHRG-HKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIP 114
Query: 346 HEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTI 405
H++F EL+E+ ++ WRETARW+KFEEDVE+ ERW KP+VA+LS SL ELR I
Sbjct: 115 HDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCI 174
Query: 406 AHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFP 465
+G LLD+ TL IA +V++ + S Q+ + R V L+ +H H N K + P
Sbjct: 175 LNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIP 234
Query: 466 RNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGH 525
S + +G P+ A ++ +D + + D H
Sbjct: 235 IVRSFAD----IGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENSTVDFSKVDLH 290
Query: 526 RGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVM 585
++KIP AEA+ +LVG + FL++ AFVRL+ AVLL+ + EVP+P RFLF++
Sbjct: 291 ------FMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFIL 344
Query: 586 LGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEG 645
LGP YHE+GRSIATLM+D++FH+ AY+A DR DL+S I EFLD V+PP E +
Sbjct: 345 LGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWD- 403
Query: 646 RDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRT 705
+ + E + +E+ K+ G TA E E G + PE L RT
Sbjct: 404 -------PSIRIEPPKNVPSQEKRKIPAVPNG--TAAHGEA--EPHGGHSGPE---LQRT 449
Query: 706 GSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLM 765
G +FGGL+ D++R+ P++ SD RDA QC+A+ LF+Y A +SP ITFGGLLGE TEG +
Sbjct: 450 GRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRI 509
Query: 766 GVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL 825
E + ++ G+ +SL G QPL ++G +GP+LVFE+ FKFC+ L YL+ R +GL
Sbjct: 510 SAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGL 569
Query: 826 WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHP------- 878
W + LVA + S LV YI+ FT+E FA LI +IFIYE KL+++ +P
Sbjct: 570 WTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDL 629
Query: 879 -LLPFY-----PPEGALEGSLDAGLEPNGSA-------LPPTE-------------GPPS 912
LL Y P G+L E N SA L +E G
Sbjct: 630 ELLTQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDH 689
Query: 913 PRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYS 972
P P+ S+IL T ++ L++F+ SR+ K R I+ DF + ++IL MVL+DY+
Sbjct: 690 P-YVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYA 748
Query: 973 ITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQ 1032
I + KL VP+ T D R WF+ PLG P P W ++AA +PALL ILIFM+ Q
Sbjct: 749 I-GIPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQ 803
Query: 1033 ITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRT 1092
ITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L +
Sbjct: 804 ITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESE 863
Query: 1093 AIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGI 1152
APG++P+ +REQRVTG++I L+G S+ M ++L+ IP+ VL+G+FLYMG +SL GI
Sbjct: 864 CSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGI 923
Query: 1153 QLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLL 1212
Q R+ L MPAKH P+ Y+ V ++HLFT IQ+ C+ LLW++K + A++ FP ++
Sbjct: 924 QFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMV 983
Query: 1213 LLTVPLRHCLLPRLFQDRELQALD 1236
L V +R L+ LF REL LD
Sbjct: 984 LALVFVRK-LMDLLFTKRELSWLD 1006
>gi|197927160 solute carrier family 4, sodium bicarbonate
cotransporter, member 4 isoform 3 [Homo sapiens]
Length = 1094
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 345 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 463
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 224
Query: 464 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 523
+ SS + + N PD P M + L D +KP +
Sbjct: 225 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 266
Query: 524 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 583
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 267 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 325
Query: 584 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 643
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 326 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 385
Query: 644 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 699
+ + + RK E Q + GG+ GG E+
Sbjct: 386 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 435
Query: 700 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 759
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 436 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 493
Query: 760 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 819
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 494 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 553
Query: 820 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 879
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 554 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 613
Query: 880 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 916
+ PP+ A + S D L P LP N
Sbjct: 614 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 671
Query: 917 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 958
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 672 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 731
Query: 959 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 1018
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 732 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 786
Query: 1019 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1078
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 787 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 846
Query: 1079 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1138
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 847 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 906
Query: 1139 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1198
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 907 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 966
Query: 1199 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1251
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 967 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 1016
>gi|4507025 solute carrier family 4, sodium bicarbonate cotransporter,
member 4 isoform 2 [Homo sapiens]
Length = 1035
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 345 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 61 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 120
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 463
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 121 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 180
Query: 464 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 523
+ SS + + N PD P M + L D +KP +
Sbjct: 181 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 222
Query: 524 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 583
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 223 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 281
Query: 584 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 643
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 282 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 341
Query: 644 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 699
+ + + RK E Q + GG+ GG E+
Sbjct: 342 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 391
Query: 700 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 759
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 392 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 449
Query: 760 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 819
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 450 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 509
Query: 820 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 879
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 510 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 569
Query: 880 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 916
+ PP+ A + S D L P LP N
Sbjct: 570 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 627
Query: 917 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 958
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 628 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 687
Query: 959 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 1018
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 688 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 742
Query: 1019 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1078
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 743 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 802
Query: 1079 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1138
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 803 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 862
Query: 1139 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1198
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 863 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 922
Query: 1199 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1251
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 923 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 972
>gi|148596928 solute carrier family 4, sodium bicarbonate
cotransporter, member 4 isoform 1 [Homo sapiens]
Length = 1079
Score = 647 bits (1669), Expect = 0.0
Identities = 385/953 (40%), Positives = 547/953 (57%), Gaps = 87/953 (9%)
Query: 345 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
P ++F EL+EL+ QE W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR
Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKD-SGF 463
+ G+ +LD E ++LP + ++V+ I + ++PE + V TLL KH H +
Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSL 224
Query: 464 FPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGD 523
+ SS + + N PD P M + L D +KP +
Sbjct: 225 ADIGKTVSSASRMFTN--------PDNGSPAMTHRNLTSSSL----NDISDKP------E 266
Query: 524 GHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLF 583
+ K+ K ++K+P DAEA+ VLVG V FL+ P AFVRL +AV+L ++ EVPVP RFLF
Sbjct: 267 KDQLKN-KFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLF 325
Query: 584 VMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEV 643
++LGP + YHE+GR+IATLMSD++FH+ AY+A DR DL++ I EFLD IV+PP E
Sbjct: 326 ILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEW 385
Query: 644 EGRDLLRSVAAFQRELLRKRR----EREQTKVEMTTRGGYTAPGKELSLELGGSEATPED 699
+ + + RK E Q + GG+ GG E+
Sbjct: 386 DPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHG----------GGGHGDCEE 435
Query: 700 DPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGE 759
L RTG GGL++D++R+ P + SD DAL+ Q ++A+LFIY A ++ AITFGGLLG+
Sbjct: 436 --LQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGD 493
Query: 760 KTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTG 819
T+ + GV E + TAV G +F L QPL ++ +GP+LVFE F F + + +YL
Sbjct: 494 ATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEF 553
Query: 820 RVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL 879
R+W+GLW L LVA + SFLV+Y + FT+E F+ LIS IFIY+ F K+ K+ +P+
Sbjct: 554 RLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPI 613
Query: 880 LPFY-------------PPEGA-LEGSLDAGLEPNGSALPPTEGPPSPRNQ--------- 916
+ PP+ A + S D L P LP N
Sbjct: 614 NSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP--EYLPTMSSTDMYHNTTFDWAFLSK 671
Query: 917 ------------------PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFG 958
P+ L+S IL LGT+ + L+KF+ S + AR++I DF
Sbjct: 672 KECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFA 731
Query: 959 IPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAV 1018
I +SIL+ ++D ++ T KL VP+ TSP+ R WF+PP G P W+ +AAA+
Sbjct: 732 IILSILIFCVID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAI 786
Query: 1019 PALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATV 1078
PALLV ILIFM+ QITA+IV++K +L KG+G+HLDL + L +C L LPW AATV
Sbjct: 787 PALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATV 846
Query: 1079 RSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1138
S+ H+++L + APG++P+ VREQRVTG L+ L GLS+ M +L+ IP+ VL+
Sbjct: 847 ISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLY 906
Query: 1139 GIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWV 1198
G+FLYMGV SL+G+Q RL L+LMP KH P+ Y+ V R+HLFT +Q+ C+ALLW+
Sbjct: 907 GVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI 966
Query: 1199 VKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1251
+KST A++ FP ++L V +R + LF +L LD D P D+ +++
Sbjct: 967 LKSTVAAIIFPVMILALVAVRKG-MDYLFSQHDLSFLD--DVIPEKDKKKKED 1016
>gi|90403614 solute carrier family 4, sodium bicarbonate
cotransporter, member 8 isoform a [Homo sapiens]
Length = 1093
Score = 643 bits (1658), Expect = 0.0
Identities = 370/928 (39%), Positives = 534/928 (57%), Gaps = 71/928 (7%)
Query: 345 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
PHE+F EL+E+ + ++ W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR
Sbjct: 113 PHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 464
+ +G LLD+ ++ I+ L+++ +S + R V LL KH H N+ K +
Sbjct: 173 LINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLI 232
Query: 465 PRNPSSSSMNSVLGNHHPTPSHGPD---GAVPTMADDLGEPAPLWPHDPDAKEKPLHMPG 521
P S + + + H HG +VPT ++ + + + P+ +
Sbjct: 233 PIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV-------KNGVNCEHSPVDLSK 285
Query: 522 GDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRF 581
D H ++KIP AEA+ VLVG V L++P AFVRL+ AVLL + EVP+P RF
Sbjct: 286 VDLH------FMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRF 339
Query: 582 LFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPS 641
LF++LGP YHE+GRS+AT+M+D++FH+ AY+A +R DLL+ I EFLD V+PP
Sbjct: 340 LFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPG 399
Query: 642 EVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDP 701
E + + + E + +E+ K+ G + E G + PE
Sbjct: 400 EWD--------PSIRIEPPKNVPSQEKRKMPGVPNGNVC----HIEQEPHGGHSGPE--- 444
Query: 702 LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKT 761
L RTG +FGGLV D++R+ P Y SD RDAL QC+A+ LF+Y A +SP ITFGGLLGE T
Sbjct: 445 LQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEAT 504
Query: 762 EGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRV 821
EG + E + ++ G+ +SL Q L ++G +GP+LVFE+ FKFC+ L YL+ R
Sbjct: 505 EGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRA 564
Query: 822 WVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL-- 879
+GLW + LVA + S LV YI+ FT+E FA LI +IFIYE KL + +P+
Sbjct: 565 CIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHM 624
Query: 880 ---------------LPFYPPEGALEGSLDAGL----------------EPNGSALPPTE 908
LP P L+ D + E +G +
Sbjct: 625 HSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSAC 684
Query: 909 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL 968
G P P+ S IL TF ++ L+ F+ SR+ + R ++ DF + ++I MV+
Sbjct: 685 GHHGPYT-PDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVI 743
Query: 969 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF 1028
+D+ I + KL VP+ T D R W I P+G P P W ++AA +PALL ILIF
Sbjct: 744 IDFLI-GVPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIF 798
Query: 1029 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT 1088
M+ QITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L
Sbjct: 799 MDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLK 858
Query: 1089 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS 1148
+ APG++P+ +REQRVTG++I L+G S+ M A+L+ IP+ VL+G+FLYMGV+S
Sbjct: 859 LESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSS 918
Query: 1149 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF 1208
L GIQ RL L MPAKH P+ Y+ V ++HLFT IQL C+ LLWV+K++ A++ F
Sbjct: 919 LQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVF 978
Query: 1209 PFLLLLTVPLRHCLLPRLFQDRELQALD 1236
P ++L V +R ++ F REL LD
Sbjct: 979 PMMVLALVFVRK-VMDLCFSKRELSWLD 1005
>gi|90568034 solute carrier family 4, sodium bicarbonate
cotransporter, member 8 isoform b [Homo sapiens]
Length = 1044
Score = 643 bits (1658), Expect = 0.0
Identities = 370/928 (39%), Positives = 534/928 (57%), Gaps = 71/928 (7%)
Query: 345 PHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 404
PHE+F EL+E+ + ++ W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR
Sbjct: 113 PHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSC 172
Query: 405 IAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFF 464
+ +G LLD+ ++ I+ L+++ +S + R V LL KH H N+ K +
Sbjct: 173 LINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLI 232
Query: 465 PRNPSSSSMNSVLGNHHPTPSHGPD---GAVPTMADDLGEPAPLWPHDPDAKEKPLHMPG 521
P S + + + H HG +VPT ++ + + + P+ +
Sbjct: 233 PIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV-------KNGVNCEHSPVDLSK 285
Query: 522 GDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRF 581
D H ++KIP AEA+ VLVG V L++P AFVRL+ AVLL + EVP+P RF
Sbjct: 286 VDLH------FMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRF 339
Query: 582 LFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPS 641
LF++LGP YHE+GRS+AT+M+D++FH+ AY+A +R DLL+ I EFLD V+PP
Sbjct: 340 LFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPG 399
Query: 642 EVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDP 701
E + + + E + +E+ K+ G + E G + PE
Sbjct: 400 EWD--------PSIRIEPPKNVPSQEKRKMPGVPNGNVC----HIEQEPHGGHSGPE--- 444
Query: 702 LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKT 761
L RTG +FGGLV D++R+ P Y SD RDAL QC+A+ LF+Y A +SP ITFGGLLGE T
Sbjct: 445 LQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEAT 504
Query: 762 EGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRV 821
EG + E + ++ G+ +SL Q L ++G +GP+LVFE+ FKFC+ L YL+ R
Sbjct: 505 EGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRA 564
Query: 822 WVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL-- 879
+GLW + LVA + S LV YI+ FT+E FA LI +IFIYE KL + +P+
Sbjct: 565 CIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHM 624
Query: 880 ---------------LPFYPPEGALEGSLDAGL----------------EPNGSALPPTE 908
LP P L+ D + E +G +
Sbjct: 625 HSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSAC 684
Query: 909 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL 968
G P P+ S IL TF ++ L+ F+ SR+ + R ++ DF + ++I MV+
Sbjct: 685 GHHGPYT-PDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVI 743
Query: 969 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF 1028
+D+ I + KL VP+ T D R W I P+G P P W ++AA +PALL ILIF
Sbjct: 744 IDFLI-GVPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIF 798
Query: 1029 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT 1088
M+ QITA+I+++K +L KG G+HLDLL++ + G+C + GLPW AATV S+THVN+L
Sbjct: 799 MDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLK 858
Query: 1089 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS 1148
+ APG++P+ +REQRVTG++I L+G S+ M A+L+ IP+ VL+G+FLYMGV+S
Sbjct: 859 LESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSS 918
Query: 1149 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF 1208
L GIQ RL L MPAKH P+ Y+ V ++HLFT IQL C+ LLWV+K++ A++ F
Sbjct: 919 LQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVF 978
Query: 1209 PFLLLLTVPLRHCLLPRLFQDRELQALD 1236
P ++L V +R ++ F REL LD
Sbjct: 979 PMMVLALVFVRK-VMDLCFSKRELSWLD 1005
>gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sapiens]
Length = 1121
Score = 606 bits (1563), Expect = e-173
Identities = 369/960 (38%), Positives = 535/960 (55%), Gaps = 87/960 (9%)
Query: 348 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 407
+F E++ L D Q W+E+ARWIKFEE VEE ERW KPHV++LS SL ELR +
Sbjct: 113 LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQT 171
Query: 408 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 467
G LLDL+ +LP I V+E I +RPE R V LL +H H P +
Sbjct: 172 GTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIH 225
Query: 468 PSSSSMNSVLGNHHPTPSHGPDGAVPTM---ADDLG-EPAPLWPHDPDAKEKPLH----M 519
S + + + + +P+ P GA P++ +DL + + A+ + ++
Sbjct: 226 RSLADIGKSVSTTNRSPARSP-GAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLT 284
Query: 520 PGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPV 579
P D + K +K KIP+D+EA+ VLVG V FL+QP AFVRL ++ +L V EVPVP
Sbjct: 285 PNTDQRKNKFMK---KIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPT 341
Query: 580 RFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIP 639
RFLF++LGPS + Y+E+GR+IATLM D LF + AY+A +R+DL++ I EFLD IV+P
Sbjct: 342 RFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLP 401
Query: 640 PSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPG----------KELS 687
P E + + RK E ++ + GG APG
Sbjct: 402 PGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGG 461
Query: 688 LELGGSEATPEDDP------------LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC 735
GG+ T D L+ TG FGGL D++R+ P +PSD D H Q
Sbjct: 462 AGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQS 521
Query: 736 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS 795
++A+LFIY ++ AITFGGLLG+ T+ GV E + TA+ G LF L QPL+++ +
Sbjct: 522 ISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSST 581
Query: 796 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA 855
GP+L+FE+ F F + L+Y+ R+W+GL V L LVA + SF+++YI+ FT+E F+
Sbjct: 582 GPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFS 641
Query: 856 FLISLIFIYETFYKLYKVFTEHPL--------LPFYPPEGALEGSLDAGLEPNGSALPPT 907
LIS IFIY+ K+ F +P+ + Y E +++ + + L P
Sbjct: 642 TLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPD 701
Query: 908 EGPP------------------------------SPRNQPNTALLSLILMLGTFFIAFFL 937
S + P+ AL+S IL GT+ + L
Sbjct: 702 TNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTL 761
Query: 938 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 997
+KF+ SR+ K R ++ DF I SIL+ +D + T KL VP+ + T PD R W
Sbjct: 762 KKFKFSRYFPTKVRALVADFSIVFSILMFCGID-ACFGLETPKLHVPSVIKPTRPD-RGW 819
Query: 998 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1057
F+ P G P W+ A+ +PALLV ILIFM+ QITA+IV++K +L K +G+HLDL
Sbjct: 820 FVAPFGKN---PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFW 876
Query: 1058 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1117
+G L LC GLPW AATV S+ H+++L + APG++PQ VREQRVTG+++
Sbjct: 877 VGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFI 936
Query: 1118 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV 1177
L G+S+ + +L+ IPL VL+G+FLYMGV SL+GIQ +R L LMPAKH P+ ++ V
Sbjct: 937 LTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHV 996
Query: 1178 KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDS 1237
R+HLFT +Q+ C+A+LW++KST A++ FP ++L + +R LL +F +L +D+
Sbjct: 997 PLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRR-LLDFIFSQHDLAWIDN 1055
>gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo
sapiens]
Length = 1137
Score = 598 bits (1541), Expect = e-170
Identities = 369/976 (37%), Positives = 536/976 (54%), Gaps = 103/976 (10%)
Query: 348 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 407
+F E++ L D Q W+E+ARWIKFEE VEE ERW KPHV++LS SL ELR +
Sbjct: 113 LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQT 171
Query: 408 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 467
G LLDL+ +LP I V+E I +RPE R V LL +H H P +
Sbjct: 172 GTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKK------PIH 225
Query: 468 PSSSSMNSVLGNHHPTPSHGPDGAVPTM---ADDLG-EPAPLWPHDPDAKEKPLH----M 519
S + + + + +P+ P GA P++ +DL + + A+ + ++
Sbjct: 226 RSLADIGKSVSTTNRSPARSP-GAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLT 284
Query: 520 PGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPV 579
P D + K +K KIP+D+EA+ VLVG V FL+QP AFVRL ++ +L V EVPVP
Sbjct: 285 PNTDQRKNKFMK---KIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPT 341
Query: 580 RFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIP 639
RFLF++LGPS + Y+E+GR+IATLM D LF + AY+A +R+DL++ I EFLD IV+P
Sbjct: 342 RFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLP 401
Query: 640 PSEVEGRDLLRSVAAFQRELLRKR--REREQTKVEMTTRGGYTAPG----------KELS 687
P E + + RK E ++ + GG APG
Sbjct: 402 PGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGG 461
Query: 688 LELGGSEATPEDDP------------LLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC 735
GG+ T D L+ TG FGGL D++R+ P +PSD D H Q
Sbjct: 462 AGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQS 521
Query: 736 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS 795
++A+LFIY ++ AITFGGLLG+ T+ GV E + TA+ G LF L QPL+++ +
Sbjct: 522 ISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSST 581
Query: 796 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA 855
GP+L+FE+ F F + L+Y+ R+W+GL V L LVA + SF+++YI+ FT+E F+
Sbjct: 582 GPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFS 641
Query: 856 FLISLIFIYETFYKLYKVFTEHPL--------LPFYPPEGALEGSLDAGLEPNGSALPPT 907
LIS IFIY+ K+ F +P+ + Y E +++ + + L P
Sbjct: 642 TLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPD 701
Query: 908 EGPP------------------------------SPRNQPNTALLSLILMLGTFFIAFFL 937
S + P+ AL+S IL GT+ + L
Sbjct: 702 TNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTL 761
Query: 938 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 997
+KF+ SR+ K R ++ DF I SIL+ +D + T KL VP+ + T PD R W
Sbjct: 762 KKFKFSRYFPTKVRALVADFSIVFSILMFCGID-ACFGLETPKLHVPSVIKPTRPD-RGW 819
Query: 998 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1057
F+ P G P W+ A+ +PALLV ILIFM+ QITA+IV++K +L K +G+HLDL
Sbjct: 820 FVAPFGKN---PWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFW 876
Query: 1058 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1117
+G L LC GLPW AATV S+ H+++L + APG++PQ VREQRVTG+++
Sbjct: 877 VGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFI 936
Query: 1118 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS----------------QRLLLI 1161
L G+S+ + +L+ IPL VL+G+FLYMGV SL+GIQ+ +R L
Sbjct: 937 LTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLF 996
Query: 1162 LMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHC 1221
LMPAKH P+ ++ V R+HLFT +Q+ C+A+LW++KST A++ FP ++L + +R
Sbjct: 997 LMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRR- 1055
Query: 1222 LLPRLFQDRELQALDS 1237
LL +F +L +D+
Sbjct: 1056 LLDFIFSQHDLAWIDN 1071
>gi|134288865 solute carrier family 4, sodium bicarbonate
cotransporter, member 7 [Homo sapiens]
Length = 1214
Score = 561 bits (1445), Expect = e-159
Identities = 321/755 (42%), Positives = 455/755 (60%), Gaps = 55/755 (7%)
Query: 530 LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPS 589
+ + KIP AEA+ VLVG V FLE+P AFVRL AVLL + EVPVP RFLF++LGP+
Sbjct: 416 MNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPA 475
Query: 590 HTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL 649
+ YHE+GRSIATLM+D++FH+ AY+A DR DLLS I EFLD V+PP E +
Sbjct: 476 GKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWD----- 530
Query: 650 RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVF 709
+ + E + +E+ K+ + G G+ + + A PE L RTG +F
Sbjct: 531 ---PSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGE--TPKEAAHHAGPE---LQRTGRLF 582
Query: 710 GGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSE 769
GGL+ D++R+ P + SD +DAL QC+A++LF+Y A +SP ITFGGLLGE TEG + E
Sbjct: 583 GGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIE 642
Query: 770 LIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVV 829
+ ++ G+ +SL QPL ++G +GP+LVFE+ +KFCR L YL+ R +GLW
Sbjct: 643 SLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSF 702
Query: 830 FVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKV--------------FT 875
+ LVA + S LV YI+ FT+E FA LI +IFIYE KL+ + T
Sbjct: 703 LCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLT 762
Query: 876 EHPLLPFYPPEGALEG-------------------SLDAGLEPNGSALPPTEGPPSPRNQ 916
+ + PP + E ++ + G L G P
Sbjct: 763 SYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP-YI 821
Query: 917 PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDT 976
P+ +IL TFF++ FL++F+ R+ K R I DF + ++I++MV +DY +
Sbjct: 822 PDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDY-LVGV 880
Query: 977 YTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITAL 1036
+ KL VP T P+ R W I PLG P W ++ AA+PALL ILIFM+ QITA+
Sbjct: 881 PSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQITAV 936
Query: 1037 IVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAP 1096
I+++K +L KG+G+HLDLL++G + G+C + GLPW AATV S++HVN+L V AP
Sbjct: 937 IINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAP 996
Query: 1097 GDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQ 1156
G++P+ +REQRVTG++I L+GLS+ M +VL+ IP+ VL+G+FLYMGV+SL GIQL
Sbjct: 997 GEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFD 1056
Query: 1157 RLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTV 1216
R+ L MPAKH P+ Y+ V W++H+FT IQL C+ LLWV+K +AA++ FP ++L V
Sbjct: 1057 RIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALV 1116
Query: 1217 PLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1251
+R L+ F REL LD D P + +D+
Sbjct: 1117 FVRK-LMDLCFTKRELSWLD--DLMPESKKKKEDD 1148
Score = 120 bits (301), Expect = 8e-27
Identities = 72/195 (36%), Positives = 103/195 (52%), Gaps = 8/195 (4%)
Query: 294 DDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRK----KKKKKLDRRPHEVF 349
+ + HR + R K S + GR SPS P R + + + PH++F
Sbjct: 54 ESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLF 113
Query: 350 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGA 409
E++EL +E W+ETARW+KFEEDVE+ +RW KP+VA+LS SL ELR I +G
Sbjct: 114 TEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGT 173
Query: 410 ALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPS 469
+LD+ +TL IA +V++ MI S Q+ R +V LL +H H N+ + F R P
Sbjct: 174 VMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPL 230
Query: 470 SSSMNSVLGNHHPTP 484
S + G H P
Sbjct: 231 VRSFADI-GKKHSDP 244
>gi|151101449 solute carrier family 4, sodium bicarbonate
cotransporter, member 9 [Homo sapiens]
Length = 959
Score = 557 bits (1436), Expect = e-158
Identities = 362/924 (39%), Positives = 494/924 (53%), Gaps = 100/924 (10%)
Query: 348 VFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAH 407
+F++LNEL L Q WRET RW+ FEE +E RW PHV +L+ SL +LR +A
Sbjct: 56 LFIQLNEL-LGWPQALEWRETGRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAE 114
Query: 408 GAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRN 467
G LLD +L + VE + + + PE R + LL + H N
Sbjct: 115 GLVLLDCPAQSLLEL----VEQVTRVESLSPELRGQLQALLLQRPQHYNQ---------- 160
Query: 468 PSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRG 527
++ G+ HP + E APL + + PL
Sbjct: 161 --TTGTRPCWGSTHPRKASD------------NEEAPL----REQCQNPLR--------- 193
Query: 528 KSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLG 587
+K+P AEA VL G + FL QP AFVRL V+L S+ EV +P RF ++LG
Sbjct: 194 ------QKLPPGAEAGTVLAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLG 247
Query: 588 PSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRD 647
P YHE+GR+ A L+SD F + +A + DLL+A+ FL+ V+PP +
Sbjct: 248 PCMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTA 307
Query: 648 LL---RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLR 704
+ + + + + L ++RE V T E G +PE L R
Sbjct: 308 RIPPPKCLPSQHKRLPSQQREIRGPAVPRLTSA-------EDRHRHGPHAHSPE---LQR 357
Query: 705 TGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGL 764
TG +FGGL++DVRR+ P YPSD DALH QC +AVL+IY A ++ AITFGGLLG+ T+G
Sbjct: 358 TGRLFGGLIQDVRRKVPWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGA 417
Query: 765 MGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVG 824
GV E + TAV G F L+ QPL ++ +GP+LVFE F F R L+YL R+WVG
Sbjct: 418 QGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVG 477
Query: 825 LWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPL----- 879
+W+ F L LVA E S LVRY + FT+E F LISLIFIY+ K+ + +P+
Sbjct: 478 IWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS 537
Query: 880 -----LPFYPPEGALEG--------------SLDAGLEPNGSALPPTEGP--------PS 912
L YP G E S+D GL N S LPP E P
Sbjct: 538 SAYGCLCQYPGPGGNESQWIRTRPKDRDDIVSMDLGLI-NASLLPPPECTRQGGHPRGPG 596
Query: 913 PRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYS 972
P+ A SL+L L +FF A L+ + SRF R+ + DF ++IL+ +D +
Sbjct: 597 CHTVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLD-A 655
Query: 973 ITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQ 1032
T KL VP T P R W + P G+ P W VAAA+PALL+ ILIFM+ Q
Sbjct: 656 FLGLATPKLMVPREFKPTLPG-RGWLVSPFGAN---PWWWSVAAALPALLLSILIFMDQQ 711
Query: 1033 ITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRT 1092
ITA+I+++ RL KG+GFHLDL + L L GLPW +ATV S+ H+++L
Sbjct: 712 ITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESR 771
Query: 1093 AIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGI 1152
A APG++P +REQR+TG+++ L G SI + VL+ IP+ VL+GIFLYMGV +LS I
Sbjct: 772 ACAPGERPNFLGIREQRLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSI 831
Query: 1153 QLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLL 1212
Q + R+ L+LMPAKH P+ + V R+HLFT IQL C+ LLW++KST A++ FP +L
Sbjct: 832 QFTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLML 891
Query: 1213 LLTVPLRHCLLPRLFQDRELQALD 1236
L V +R L R+F +EL LD
Sbjct: 892 LGLVGVRKA-LERVFSPQELLWLD 914
>gi|14042960 solute carrier family 4 member 11 [Homo sapiens]
Length = 891
Score = 253 bits (645), Expect = 1e-66
Identities = 200/690 (28%), Positives = 328/690 (47%), Gaps = 78/690 (11%)
Query: 579 VRFLFVMLGPSH--TSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSI 636
VRF+ ++L P ++ E+ R+ AT+ SD F RQ LL +E
Sbjct: 247 VRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAF---------RQKLLETRTE------ 291
Query: 637 VIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEAT 696
+ + QR+LL M + G KE S +
Sbjct: 292 ----------EEFKEALVHQRQLLT-----------MVSHGPVAPRTKERSTVSLPAHRH 330
Query: 697 PEDDPLLRTGSVFG-GLVRDVRRRYPHYPSDLRDALHSQ------CVAAVLFIYFAALSP 749
PE P + FG G+ D+ RR+P YP D D + + + LF+YFA L P
Sbjct: 331 PEP-PKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLP 389
Query: 750 AITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFC 809
I FG L E T+G + V + I ++ G+L++L QPL+++ + PL ++ + C
Sbjct: 390 TIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVIC 449
Query: 810 RAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYK 869
DL++ + W GLW F+ S ++ T+EI A IS+ F+ +
Sbjct: 450 DDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKG 509
Query: 870 LYKVFTE----HPLLPFYPPE-------GALEGSLDAGLEP--NGSAL-PPTEGPPSPRN 915
K+F + H L ++ L SL+A L N S L PTE P + +
Sbjct: 510 TVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHS 569
Query: 916 QPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLV-DYSIT 974
TA+LSL++MLGT ++ + L +F+ S +L R I+ D +PI++L L+ +
Sbjct: 570 GQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFR 629
Query: 975 DTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVP-ALLVLILIFMETQI 1033
+ K +P + + + + S V+ A+ L+ +L F+E +
Sbjct: 630 EIEMSKFRY-------NPSESPFAMAQIQSL----SLRAVSGAMGLGFLLSMLFFIEQNL 678
Query: 1034 TALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTA 1093
A +V+ RL+KG+ +H DLLL+ + LFGLPW+ AA S HV AL ++
Sbjct: 679 VAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEER 738
Query: 1094 IAPGD-KPQIQEVREQRVTGVLIASLVGLSIVMGAV-LRRIPLAVLFGIFLYMGVTSLSG 1151
+ G I V+E R+T + + LVGLS+++ V L+ IP VL+G+FLY+ +TSL G
Sbjct: 739 VENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDG 798
Query: 1152 IQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA---ASLAF 1208
QL QR+ L+L +P Y+ +V ++H FT +Q+ + LL ++ + F
Sbjct: 799 NQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIF 858
Query: 1209 PFLLLLTVPLRHCLLPRLFQDRELQALDSE 1238
P +++ +P+R+ LLPR+ + + L +D+E
Sbjct: 859 PLIMIAMIPIRYILLPRIIEAKYLDVMDAE 888
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/315 (23%), Positives = 113/315 (35%), Gaps = 52/315 (16%)
Query: 48 GDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTR 107
G + S+ A PE+ S S SE + T P + L + A
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEET------PAAKALLQAKASGKTSQVGAASAP 300
Query: 108 RKRKKEKTSAPPSEG-TPPIQEEGGAGVDEEEEEEEEEEGESEAE-PVEPPPSG-TPQKA 164
K K +AP G T P + AG EE+ + EE +SE E P + PSG PQ
Sbjct: 301 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 360
Query: 165 KFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDK----SPQHSSRPCSELRDGDGTTDLAL 220
S + E P + A P GP + + SR SE D D A+
Sbjct: 361 AASAPAKES-----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM 415
Query: 221 SSPRLLCCLPSSPSPRARASRLAG-------------EKSRPWSPSASYDLRERLCPGSA 267
++ ++ P SP+ + + G K P +PSA E S+
Sbjct: 416 NAAQV---KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS 472
Query: 268 LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG 327
+ + +VPT A AQ ++ L KP+ + +G P
Sbjct: 473 EESSDSSDGEVPTAVAPAQEKSLGNI-----------------LQAKPT-SSPAKGPPQK 514
Query: 328 LAPILRRKKKKKKLD 342
P+ + K +K +D
Sbjct: 515 AGPVAVQVKAEKPMD 529
Score = 33.1 bits (74), Expect = 1.7
Identities = 52/231 (22%), Positives = 86/231 (37%), Gaps = 30/231 (12%)
Query: 112 KEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFS---- 167
K T APP + + +E+ E EE +SE E P + +AK S
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE---ETPAAKALLQAKASGKTS 292
Query: 168 -IGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSP----QHSSRPCSELRDGDGTTDLALSS 222
+G+ + P + A P GP K+ + S+ SE D +
Sbjct: 293 QVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK- 351
Query: 223 PRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQ--QVPT 280
PS +P+ RA+ A K P +A R + P +A G E+ + +
Sbjct: 352 -------PSGKAPQVRAAS-APAKESPRKGAAPAPPR-KTGPAAAQVQVGKQEEDSRSSS 402
Query: 281 DEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPI 331
+E+++ A ++ + L +P V KP+ T G G P+
Sbjct: 403 EESDSDREALAAMNAAQVKPLGKSPQV------KPASTMGMGPLGKGAGPV 447
Score = 33.1 bits (74), Expect = 1.7
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%)
Query: 128 EEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKP 187
EE +EE + EEE E ++ + PSG + + ++ ++ P + A P
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVK-----PSGKTHQIRAALAPAKES----PRKGAAPTP 838
Query: 188 LPSVGPHTDKS-PQHSSRPCSELRDGDGTTDLALSS-----PRLLCCLPS-SPSPRARAS 240
GP ++ Q S SE D DG A++S P L+ P+ SP+ A
Sbjct: 839 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 898
Query: 241 RLAGEKSRPWSPSAS 255
A S P AS
Sbjct: 899 AQAQAASTPRKARAS 913
Score = 31.2 bits (69), Expect = 6.5
Identities = 71/279 (25%), Positives = 101/279 (36%), Gaps = 52/279 (18%)
Query: 98 LPPTS-------ARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEA 150
LP TS A+ T + RK + + P ++ D EE+ EG A
Sbjct: 1030 LPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGA 1089
Query: 151 EP----VEPPPSGTPQKAKFSIG-SDEDD-------------SPGL-PGRAAVTKPLPSV 191
+ V P PS T + + S EDD +PGL P + +K P +
Sbjct: 1090 KSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL 1149
Query: 192 GPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSR--- 248
D SP SS ++ D DG + + L + AS +KSR
Sbjct: 1150 ----DSSPSVSSTLAAK-DDPDGKQE--AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1202
Query: 249 --PWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPG 306
+P AS + LG P P +EA+ Q A + + + LE
Sbjct: 1203 KGAGNPQASTLALQSNITQCLLGQPW------PLNEAQVQ----ASVVKVLTELLEQERK 1252
Query: 307 VRRHLVKKPSRT--QGGRGSPSGLAPILR--RKKKKKKL 341
K+ SR + + SG P R R KKKKKL
Sbjct: 1253 KVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL 1291
Score = 30.8 bits (68), Expect = 8.5
Identities = 57/280 (20%), Positives = 94/280 (33%), Gaps = 62/280 (22%)
Query: 87 ARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEG 146
A++ P K ++ A + +K PP + P + G EE + +G
Sbjct: 808 AQVKPSGKTHQIRAALAP-AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 866
Query: 147 E-----SEAEPVEPP---------PSG------------TPQKAKF------SIGSDEDD 174
E + A+ ++PP P+G TP+KA+ S S+ +D
Sbjct: 867 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 926
Query: 175 SPGLPGRAAVTKPL-----------PSVGPHTDKSPQHSSRPCSELRDG----DGTTDLA 219
+P +T + P + P + SS+ S + DG T ++
Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986
Query: 220 LSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSA------------ 267
+P L ++ A+ + A PS+ D P ++
Sbjct: 987 KKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTN 1046
Query: 268 -LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPG 306
L P PE Q T E+ S D D S ED G
Sbjct: 1047 KLRKPKLPEVQQATKAPESSD-DSEDSSDSSSGSEEDGEG 1085
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/315 (23%), Positives = 113/315 (35%), Gaps = 52/315 (16%)
Query: 48 GDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTR 107
G + S+ A PE+ S S SE + T P + L + A
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEET------PAAKALLQAKASGKTSQVGAASAP 300
Query: 108 RKRKKEKTSAPPSEG-TPPIQEEGGAGVDEEEEEEEEEEGESEAE-PVEPPPSG-TPQKA 164
K K +AP G T P + AG EE+ + EE +SE E P + PSG PQ
Sbjct: 301 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 360
Query: 165 KFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDK----SPQHSSRPCSELRDGDGTTDLAL 220
S + E P + A P GP + + SR SE D D A+
Sbjct: 361 AASAPAKES-----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM 415
Query: 221 SSPRLLCCLPSSPSPRARASRLAG-------------EKSRPWSPSASYDLRERLCPGSA 267
++ ++ P SP+ + + G K P +PSA E S+
Sbjct: 416 NAAQV---KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS 472
Query: 268 LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSG 327
+ + +VPT A AQ ++ L KP+ + +G P
Sbjct: 473 EESSDSSDGEVPTAVAPAQEKSLGNI-----------------LQAKPT-SSPAKGPPQK 514
Query: 328 LAPILRRKKKKKKLD 342
P+ + K +K +D
Sbjct: 515 AGPVAVQVKAEKPMD 529
Score = 33.1 bits (74), Expect = 1.7
Identities = 52/231 (22%), Positives = 86/231 (37%), Gaps = 30/231 (12%)
Query: 112 KEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFS---- 167
K T APP + + +E+ E EE +SE E P + +AK S
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE---ETPAAKALLQAKASGKTS 292
Query: 168 -IGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSP----QHSSRPCSELRDGDGTTDLALSS 222
+G+ + P + A P GP K+ + S+ SE D +
Sbjct: 293 QVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK- 351
Query: 223 PRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQ--QVPT 280
PS +P+ RA+ A K P +A R + P +A G E+ + +
Sbjct: 352 -------PSGKAPQVRAAS-APAKESPRKGAAPAPPR-KTGPAAAQVQVGKQEEDSRSSS 402
Query: 281 DEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPI 331
+E+++ A ++ + L +P V KP+ T G G P+
Sbjct: 403 EESDSDREALAAMNAAQVKPLGKSPQV------KPASTMGMGPLGKGAGPV 447
Score = 33.1 bits (74), Expect = 1.7
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%)
Query: 128 EEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKP 187
EE +EE + EEE E ++ + PSG + + ++ ++ P + A P
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVK-----PSGKTHQIRAALAPAKES----PRKGAAPTP 838
Query: 188 LPSVGPHTDKS-PQHSSRPCSELRDGDGTTDLALSS-----PRLLCCLPS-SPSPRARAS 240
GP ++ Q S SE D DG A++S P L+ P+ SP+ A
Sbjct: 839 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 898
Query: 241 RLAGEKSRPWSPSAS 255
A S P AS
Sbjct: 899 AQAQAASTPRKARAS 913
Score = 33.1 bits (74), Expect = 1.7
Identities = 73/281 (25%), Positives = 104/281 (37%), Gaps = 57/281 (20%)
Query: 98 LPPTS-------ARHTRRKRK------KEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEE 144
LP TS A+ T + RK ++ T AP S + +G EE+ E
Sbjct: 1030 LPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSG---SEEDGEGP 1086
Query: 145 EGESEAEPVEPPPSGTPQKAKFSIG-SDEDD-------------SPGL-PGRAAVTKPLP 189
+G A + P PS T + + S EDD +PGL P + +K P
Sbjct: 1087 QGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP 1146
Query: 190 SVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSR- 248
+ D SP SS ++ D DG + + L + AS +KSR
Sbjct: 1147 KL----DSSPSVSSTLAAK-DDPDGKQE--AKPQQAAGMLSPKTGGKEAASGTTPQKSRK 1199
Query: 249 ----PWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDN 304
+P AS + LG P P +EA+ Q A + + + LE
Sbjct: 1200 PKKGAGNPQASTLALQSNITQCLLGQPW------PLNEAQVQ----ASVVKVLTELLEQE 1249
Query: 305 PGVRRHLVKKPSRT--QGGRGSPSGLAPILR--RKKKKKKL 341
K+ SR + + SG P R R KKKKKL
Sbjct: 1250 RKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL 1290
Score = 32.0 bits (71), Expect = 3.8
Identities = 62/298 (20%), Positives = 101/298 (33%), Gaps = 67/298 (22%)
Query: 87 ARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEG 146
A++ P K ++ A + +K PP + P + G EE + +G
Sbjct: 808 AQVKPSGKTHQIRAALAP-AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 866
Query: 147 E-----SEAEPVEPP---------PSG------------TPQKAKF------SIGSDEDD 174
E + A+ ++PP P+G TP+KA+ S S+ +D
Sbjct: 867 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 926
Query: 175 SPGLPGRAAVTKPL-----------PSVGPHTDKSPQHSSRPCSELRDG----DGTTDLA 219
+P +T + P + P + SS+ S + DG T ++
Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986
Query: 220 LSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSA------------ 267
+P L ++ A+ + A PS+ D P ++
Sbjct: 987 KKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTN 1046
Query: 268 -LGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVR-----RHLVKKPSRTQ 319
L P PE Q T E+ S D D S ED G + L PSRT+
Sbjct: 1047 KLRKPKLPEVQQATKAPESSD-DSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTE 1103
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 51.2 bits (121), Expect = 6e-06
Identities = 71/269 (26%), Positives = 89/269 (33%), Gaps = 37/269 (13%)
Query: 6 IPPPGGASPLPQVRVPLEEPPLSPDVEE---EDDDLGKTLAVSRFGDLISKPPAWDPEKP 62
+ PP ASPL P EE PLSP EE L+ +S PP P P
Sbjct: 536 LSPPPEASPLSP---PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP 592
Query: 63 SRSYSER--DFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPP- 119
S FE + PLS PPP R PP ++ S PP
Sbjct: 593 PPEASRLFPPFEESPLSPPPEESPLS---PPPEASRLSPPPEDSPMSPPPEESPMSPPPE 649
Query: 120 ----------SEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIG 169
S +PP +E + EE E + P E P+ P + +
Sbjct: 650 VSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASP 709
Query: 170 SDEDDSPGLPGRAAVTKPLP--------SVGPHTDKSPQH---SSRPCSELRDGDGTTDL 218
ED LP + PLP S GPH P+ S RP
Sbjct: 710 PPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPH 769
Query: 219 ALSSPR--LLCCLPSSP--SPRARASRLA 243
P LC +P P SP+A L+
Sbjct: 770 LSPQPEEPCLCAVPEEPHLSPQAEGPHLS 798
Score = 49.3 bits (116), Expect = 2e-05
Identities = 80/317 (25%), Positives = 104/317 (32%), Gaps = 65/317 (20%)
Query: 16 PQVRVPL-EEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFH 74
PQ+ PL EE PL P EE +S PP P P
Sbjct: 428 PQLEAPLNEEMPLLPPPEESP---------------LSPPPEESPTSPP----------- 461
Query: 75 RHTSHHTHHPLSARL-PPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEG--TPPIQEEGG 131
P ++RL PPP +L P A H R ++ S PP E +PP +
Sbjct: 462 ---------PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPF 512
Query: 132 AGVDEEEEEEEEEEGESEA--EPVEPPPSGTPQKAKFS---IGSDEDDSP-GLPGRAAVT 185
+ ++E EE S A P+ PPP +P F + ++ P P A+
Sbjct: 513 SPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL 572
Query: 186 KPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLA-- 243
P P P SP P S + SP S SP ASRL+
Sbjct: 573 SPPPEESP---MSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPP 629
Query: 244 --------GEKSRPWSPSASYDLRERLCPGSALGNP-------GGPEQQVPTDEAEAQML 288
+ P SP L S L P PE+ + EA L
Sbjct: 630 PEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRL 689
Query: 289 GSADLDDMKSHRLEDNP 305
D S ED+P
Sbjct: 690 SPPPEDSPTSPPPEDSP 706
Score = 34.7 bits (78), Expect = 0.59
Identities = 62/250 (24%), Positives = 82/250 (32%), Gaps = 42/250 (16%)
Query: 16 PQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHR 75
P + EEP LSP EE L + + P P+ S + E H
Sbjct: 759 PHLSPQAEEPHLSPQPEEP------CLCA------VPEEPHLSPQAEGPHLSPQPEELHL 806
Query: 76 HTSHHTHH----PLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTP------- 124
H P L P + L P S R +E +P E P
Sbjct: 807 SPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEK 866
Query: 125 PIQEEGGAGVDEE--------EEEEEEEEGESE-AEPVEPPPSGTPQKAKFSIGSDEDDS 175
P +E G EE E GE +EP EPP S P++ S + S
Sbjct: 867 PPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLS 926
Query: 176 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELR-----DGDGTTDLALSSPRLLCCLP 230
P L + PL P + + P EL GD + L++P L P
Sbjct: 927 PQLMPPDPLPPPL---SPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILE--TP 981
Query: 231 SSPSPRARAS 240
SP P A +
Sbjct: 982 ISPPPEANCT 991
Score = 32.0 bits (71), Expect = 3.8
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 3/73 (4%)
Query: 109 KRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPV--EPPPSGTPQKAKF 166
+RK+ TS +G P I +E G++ + + E+G +A PV +P GTP +
Sbjct: 1813 ERKELPTSQKGDDG-PDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGML 1871
Query: 167 SIGSDEDDSPGLP 179
S D + LP
Sbjct: 1872 SSDLDRISTEELP 1884
>gi|239757043 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 996
Score = 50.1 bits (118), Expect = 1e-05
Identities = 54/227 (23%), Positives = 73/227 (32%), Gaps = 34/227 (14%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE---------GGAGV------DEEEEEEEEEEGESEAEPVEPPPSGTPQKAKF 166
PP+ + GG E+E++EEEE E + E +PP ++ +
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCSYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGR- 761
Query: 167 SIGSDEDDSPGLPGRAAVTKPLPSVGPHTD-KSPQHSSRPCSELRDGDGTTDLALSSPRL 225
D+D+ + PL G + P G L L+S RL
Sbjct: 762 --DPDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRL 819
Query: 226 L-----------CCLPSSPSPRARASRLAGEKSRPWSPSASYDLRER 261
L P P P A G S P SP L E+
Sbjct: 820 LQEDGKLGDPGSDLPPPPPPPLAPQKASGGGSSSPGSPVHHPSLEEQ 866
>gi|239751555 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 50.1 bits (118), Expect = 1e-05
Identities = 54/227 (23%), Positives = 73/227 (32%), Gaps = 34/227 (14%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE---------GGAGV------DEEEEEEEEEEGESEAEPVEPPPSGTPQKAKF 166
PP+ + GG E+E++EEEE E + E +PP ++ +
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCCYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGR- 761
Query: 167 SIGSDEDDSPGLPGRAAVTKPLPSVGPHTD-KSPQHSSRPCSELRDGDGTTDLALSSPRL 225
D+D+ + PL G + P G L L+S RL
Sbjct: 762 --DPDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRL 819
Query: 226 L-----------CCLPSSPSPRARASRLAGEKSRPWSPSASYDLRER 261
L P P P A G S P SP L E+
Sbjct: 820 LQEDGKLGDPGSDLPPPPPPPLAPQKASGGGSSSPGSPVHHPSLEEQ 866
>gi|239746067 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 50.1 bits (118), Expect = 1e-05
Identities = 54/227 (23%), Positives = 73/227 (32%), Gaps = 34/227 (14%)
Query: 62 PSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSE 121
P + + H H HH HHP PP L LPP + PP
Sbjct: 647 PHSAQTHPHHHHHPHHHHHHHHPPQ----PPSPLLLLPPQPDEPGSERHHPAPPPPPPPP 702
Query: 122 GTPPIQEE---------GGAGV------DEEEEEEEEEEGESEAEPVEPPPSGTPQKAKF 166
PP+ + GG E+E++EEEE E + E +PP ++ +
Sbjct: 703 PPPPLAQHPHHRGLLSPGGTSCCYPSEDSSEDEDDEEEEQEVDVEGHKPPEGEEEEEGR- 761
Query: 167 SIGSDEDDSPGLPGRAAVTKPLPSVGPHTD-KSPQHSSRPCSELRDGDGTTDLALSSPRL 225
D+D+ + PL G + P G L L+S RL
Sbjct: 762 --DPDDDEEEDEETEVLLGDPLVGGGRFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRL 819
Query: 226 L-----------CCLPSSPSPRARASRLAGEKSRPWSPSASYDLRER 261
L P P P A G S P SP L E+
Sbjct: 820 LQEDGKLGDPGSDLPPPPPPPLAPQKASGGGSSSPGSPVHHPSLEEQ 866
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 48.5 bits (114), Expect = 4e-05
Identities = 66/246 (26%), Positives = 97/246 (39%), Gaps = 46/246 (18%)
Query: 118 PPSEGTPPIQEEGGAGVDEE----EEEEEEEEGESEAEPVEPPPSGTPQKAK----FSIG 169
P S+ P QEEG GVDE+ EE EEE+ E + E E + TPQ+ K S
Sbjct: 285 PESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEE 344
Query: 170 SDEDDSPGLPGRA--AVTKPLPSVGPHTDKSP-----QHSSRPCSELRDGDGTTDLALSS 222
SD + + A A+ P ++ P + +SRP + +G T
Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGST------- 397
Query: 223 PRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPG----SALGNPGGPEQQV 278
S + RA AS+L K P+A R RL G S P P +
Sbjct: 398 ---------SSTLRAAASKLEQGKRVSEMPAAK---RLRLDTGPQSLSGKSTPQPPSGKT 445
Query: 279 PTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSP---SGLAPILRRK 335
+ + Q+ +D L P + L+KK + G S + LA IL+R
Sbjct: 446 TPNSGDVQV-----TEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRL 500
Query: 336 KKKKKL 341
++K+
Sbjct: 501 NPERKM 506
Score = 35.4 bits (80), Expect = 0.35
Identities = 57/239 (23%), Positives = 89/239 (37%), Gaps = 30/239 (12%)
Query: 103 ARHTRRKRKKEKTSAPPSEGTPPIQEEGGAG---VDEEEEEEEEEEGESEAEPVEPPPSG 159
A+ R+K+KK+ + E + EG D +EE E +++A E P G
Sbjct: 241 AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG 300
Query: 160 TPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLA 219
+++ S S+E+ P K P+ P K + SS + D ++
Sbjct: 301 VDEQSDSSEESEEEKPPEEDKEEEEEKKAPT--PQEKKRRKDSSEESDSSEESDIDSE-- 356
Query: 220 LSSPRLLCCLPSSPSPRARASRLAGEK--SRPWSPSA-----SYDLR---ERLCPGSALG 269
+S L +P R R + SRP +PSA S LR +L G +
Sbjct: 357 -ASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVS 415
Query: 270 N-PGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPG--------VRRHLVKKPSRTQ 319
P ++ T Q L S + N G VRR+L +KP T+
Sbjct: 416 EMPAAKRLRLDTG---PQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTK 471
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 48.1 bits (113), Expect = 5e-05
Identities = 62/202 (30%), Positives = 86/202 (42%), Gaps = 23/202 (11%)
Query: 86 SARLP--PPHKLRRLPPTSARHTRRKRKKEKT---SAPPSEGTPPIQEEGGAGVDEEEEE 140
+A++P PP K PP ++ KT S P E T GGA +EEEEE
Sbjct: 970 AAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEE 1029
Query: 141 -EEEEEGESEAEPVEPPPSGTPQKAKF---SIGSDEDDSPGLPGRAAVTKPLPSVGPHTD 196
EEEEE E E +P + T A S GS DS G A+ LP++ P
Sbjct: 1030 EEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPP--- 1086
Query: 197 KSPQHSSRPCSELRDGDGTTDLALSSPRLLCCL-PSSPSPRARASRLAGEKSRPWS---P 252
P + P D TT L+ LL + ++ + RA+A L ++ S P
Sbjct: 1087 --PMPWNLPAGV----DCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP 1140
Query: 253 SASYDLRERLCPGSALGNPGGP 274
+S + P ++LG P GP
Sbjct: 1141 PSSLGMTPAPVP-TSLGLPPGP 1161
Score = 39.3 bits (90), Expect = 0.024
Identities = 34/118 (28%), Positives = 48/118 (40%), Gaps = 7/118 (5%)
Query: 100 PTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSG 159
PT ++ ++K G+ P G +EEEEEEEEEE E E E E S
Sbjct: 233 PTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQ 292
Query: 160 TPQKAKFSIGSDEDD---SPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDG 214
+ + ++ DD S PG + P P P T +P + P + DG
Sbjct: 293 SISRISETLAGIYDDNSLSQDFPGDES---PRPDAQP-TQPTPAPGTPPQVDSTRADG 346
>gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo
sapiens]
Length = 307
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/288 (23%), Positives = 94/288 (32%), Gaps = 64/288 (22%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 15 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 58
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 59 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 115
Query: 176 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP 235
PGLP AA P + C ++ SP P
Sbjct: 116 PGLPSAAAA-------------RPARKTLTCQ---------PRSIESPATASSAGCGSGP 153
Query: 236 RARASRLAGEKSRPWSPSASYDLRER-------------LCPGSALGNPGGP--EQQVPT 280
R RL G RP SP+ R+ A G+PGG Q++
Sbjct: 154 RVPQVRLLGPGGRPSSPARDGSRRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTL 213
Query: 281 DEAEAQMLGSADLDDMKSHRLE----DNPGVRR-HLVKKPSRTQGGRG 323
EA ++ S ++ H D P RR H + + GGRG
Sbjct: 214 LPVEASLILSVVAAVLQLHSYRRPAGDTPDPRRGHHRHRRRQRGGGRG 261
>gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo
sapiens]
Length = 325
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/288 (23%), Positives = 94/288 (32%), Gaps = 64/288 (22%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 33 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 76
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 77 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 133
Query: 176 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP 235
PGLP AA P + C ++ SP P
Sbjct: 134 PGLPSAAAA-------------RPARKTLTCQ---------PRSIESPATASSAGCGSGP 171
Query: 236 RARASRLAGEKSRPWSPSASYDLRER-------------LCPGSALGNPGGP--EQQVPT 280
R RL G RP SP+ R+ A G+PGG Q++
Sbjct: 172 RVPQVRLLGPGGRPSSPARDGSRRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTL 231
Query: 281 DEAEAQMLGSADLDDMKSHRLE----DNPGVRR-HLVKKPSRTQGGRG 323
EA ++ S ++ H D P RR H + + GGRG
Sbjct: 232 LPVEASLILSVVAAVLQLHSYRRPAGDTPDPRRGHHRHRRRQRGGGRG 279
>gi|239744803 PREDICTED: hypothetical protein XP_002343287 [Homo
sapiens]
Length = 325
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/288 (23%), Positives = 94/288 (32%), Gaps = 64/288 (22%)
Query: 59 PEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAP 118
P P+ ++ R HT H T HP S+ PP H LPPT
Sbjct: 33 PANPAPFHTPRKRHPLSHTPHATAHPPSSP-PPLHITPVLPPTFP--------------- 76
Query: 119 PSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPP---PSGTPQKAKFSIGSDEDDS 175
GT P + A E ++EE ++ P+ PP G +GS
Sbjct: 77 ---GTQPPRALRLAEGSGEGKQEEGRRAQARPRPLRPPWEVRGGARGPCSAPVGSRASSG 133
Query: 176 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP 235
PGLP AA P + C ++ SP P
Sbjct: 134 PGLPSAAAA-------------RPARKTLTCQ---------PRSIESPATASSAGCGSGP 171
Query: 236 RARASRLAGEKSRPWSPSASYDLRER-------------LCPGSALGNPGGP--EQQVPT 280
R RL G RP SP+ R+ A G+PGG Q++
Sbjct: 172 RVPQVRLLGPGGRPSSPARDGSRRKAGHGCTSQSQGDAVAMEAEARGSPGGRVLMQELTL 231
Query: 281 DEAEAQMLGSADLDDMKSHRLE----DNPGVRR-HLVKKPSRTQGGRG 323
EA ++ S ++ H D P RR H + + GGRG
Sbjct: 232 LPVEASLILSVVAAVLQLHSYRRPAGDTPDPRRGHHRHRRRQRGGGRG 279
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 45.8 bits (107), Expect = 3e-04
Identities = 64/269 (23%), Positives = 91/269 (33%), Gaps = 69/269 (25%)
Query: 11 GASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERD 70
GA LP +V +EP + EE T A D + A +P +P +RD
Sbjct: 886 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRD 945
Query: 71 FEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEG 130
E + + K K+ A SEG QE
Sbjct: 946 EE--------------------------------RGKTQGKHRKSFALDSEGEEASQESS 973
Query: 131 GAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPS 190
+E++EE+EE+E EA T ++ + S G DE+
Sbjct: 974 SEKDEEDDEEDEEDEDREEAVDT------TKKETEVSDGEDEESD--------------- 1012
Query: 191 VGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPW 250
SS CS D DG D S SS S + +S + S
Sbjct: 1013 -----------SSSKCSLYADSDGENDSTSDSE----SSSSSSSSSSSSSSSSSSSSSSS 1057
Query: 251 SPSASYDLRERLCPGSALGNPGGPEQQVP 279
S S+S D E P +AL + P ++VP
Sbjct: 1058 SESSSEDEEEEERP-AALPSASPPPREVP 1085
Score = 38.5 bits (88), Expect = 0.041
Identities = 30/109 (27%), Positives = 39/109 (35%), Gaps = 17/109 (15%)
Query: 65 SYSERDFEFHRHTSHHTHHPLSARLP------------PPHKLRRLPPTSARHTRRKRKK 112
+Y E + RHTS+ P PP LPP +R T + +
Sbjct: 368 AYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRP 427
Query: 113 EKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTP 161
+ APP E P GG G E EE + P P SG+P
Sbjct: 428 PASEAPPPEPPEPGGGGGGGGPSPEREEV-----RTSPRPASPARSGSP 471
>gi|226371735 iroquois homeobox 3 [Homo sapiens]
Length = 501
Score = 45.8 bits (107), Expect = 3e-04
Identities = 62/249 (24%), Positives = 91/249 (36%), Gaps = 34/249 (13%)
Query: 58 DPEKPSRSYSERDFEFHRHTSHHTHHPLSAR-------LPPPHKLRRLPPTSARHTRRKR 110
DP +P + E + H +P + + L ++ A RR +
Sbjct: 127 DPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 186
Query: 111 KKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQK--AKFSI 168
K+ K + P T G+ +EE+EEE+EE+G+ E E E G + +
Sbjct: 187 KENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDTGGEGLA 246
Query: 169 GSDEDDSPGLPG-RAAVTKPLPS------------VGPHTDKSPQHSSRPCSELRDGD-G 214
DED+ L A T+P S +GP +D S L D
Sbjct: 247 DDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDRPLP 306
Query: 215 TTDLALSSPRLLCCLPSSPSP--------RARASRLAGEKSRPWS---PSASYDLRERLC 263
LA + P + PS PSP A A A +K + WS + S D R
Sbjct: 307 VLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRSP 366
Query: 264 PGSALGNPG 272
PG+ PG
Sbjct: 367 PGAGGSPPG 375
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
Length = 2524
Score = 45.4 bits (106), Expect = 3e-04
Identities = 60/221 (27%), Positives = 89/221 (40%), Gaps = 30/221 (13%)
Query: 93 HKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPI---QEEGGAGVDEEEEEEEEEEGESE 149
HKL+ R+ RRK+KK +A PP+ +E +GV EEE EE
Sbjct: 669 HKLKM---EKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALH 725
Query: 150 AEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSP---QHSSRPC 206
A E P E P ++ T+ +PS PHT+ + Q+ +P
Sbjct: 726 ASGNEVP-------------RGECSGPATVNNSSDTESIPS--PHTEAAKDTGQNGPKPP 770
Query: 207 SELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDL--RERLCP 264
+ L DG + P P+ P+P + A+ P SPSA + +E
Sbjct: 771 ATL-GADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEE 829
Query: 265 GSALGNP--GGPEQQVPTDEAEAQMLGSADLDDMKSHRLED 303
+A P G EQ+ P E A G A+ + +KS E+
Sbjct: 830 ETAAAPPVEEGEEQKPPAAEELAVDTGKAE-EPVKSECTEE 869
Score = 35.8 bits (81), Expect = 0.26
Identities = 54/185 (29%), Positives = 69/185 (37%), Gaps = 30/185 (16%)
Query: 85 LSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEE- 143
L A PPP P T E T AP PP V +EE+EEE
Sbjct: 773 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETA 832
Query: 144 -----EEGESEAEP------VEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVT------- 185
EEGE + P V+ + P K++ + ++E + G AA
Sbjct: 833 AAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALK 892
Query: 186 ---KPLPSVGPHTDKS---PQ--HSSRPCS--ELRDGDGTTDLALSSPRLLCCLPSSPSP 235
K S T KS PQ SS CS E+ + +G L SPR P+ P
Sbjct: 893 AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTG-DP 951
Query: 236 RARAS 240
RA AS
Sbjct: 952 RANAS 956
Score = 33.5 bits (75), Expect = 1.3
Identities = 37/134 (27%), Positives = 46/134 (34%), Gaps = 25/134 (18%)
Query: 82 HHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQ----EEGGAGVDEE 137
HHP P P L P S +R PP + P + EGG E
Sbjct: 2157 HHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEP 2216
Query: 138 EEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTD- 196
+ GE EPV PP T PG R+AV L G T+
Sbjct: 2217 NKTSVLGGGEDGIEPVSPPEGMT--------------EPG-HSRSAVYPLLYRDGEQTEP 2261
Query: 197 -----KSPQHSSRP 205
KSP ++S+P
Sbjct: 2262 SRMGSKSPGNTSQP 2275
>gi|145275189 specifically androgen-regulated protein isoform 1
[Homo sapiens]
Length = 601
Score = 45.1 bits (105), Expect = 4e-04
Identities = 63/270 (23%), Positives = 88/270 (32%), Gaps = 49/270 (18%)
Query: 58 DPEKPSRSYSERDFEFHRHTSHHTHHPLSAR----------LPPPHKLRRLPPTSARHTR 107
+P +P R E + E +S P S + +PPP R P R
Sbjct: 157 NPGEPGRLAPEPEKEQVSQSSQPRQAPASPQEAALDLDVVLIPPPEAFRDTQPEQCREAS 216
Query: 108 RKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFS 167
+ P TP +E E ++ +E + +PPP+G PQ A+
Sbjct: 217 LPEGPGQQGHTPQLHTPSSSQEREQTPSEAMSQKAKETVSTRYTQPQPPPAGLPQNARAE 276
Query: 168 ---IGSDEDDSPGLPGRAAVTKPLPSVGP------------HTDKSPQHSSRPCSELRDG 212
+ S ED + L A +T P P P H+D PQH +E G
Sbjct: 277 DAPLSSGEDPNSRL---APLTTPKPRKLPPNIVLKSSRSSFHSD--PQHWLSRHTEAAPG 331
Query: 213 DGTTDLALSSPRLLCCLPSSPSPRARASRLAG----------EKSRPWSPSASYDLR-ER 261
D S + C L R A G S+P S + R +
Sbjct: 332 D--------SGLISCSLQEQRKARKEALEKLGLPQDQDEPGLHLSKPTSSIRPKETRAQH 383
Query: 262 LCPGSALGNPGGPEQQVPTDEAEAQMLGSA 291
L P L P P Q A + L A
Sbjct: 384 LSPAPGLAQPAAPAQASAAIPAAGKALAQA 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,411,363
Number of Sequences: 37866
Number of extensions: 3157373
Number of successful extensions: 30382
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 713
Number of HSP's that attempted gapping in prelim test: 21005
Number of HSP's gapped (non-prelim): 5952
length of query: 1259
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1145
effective length of database: 13,930,794
effective search space: 15950759130
effective search space used: 15950759130
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.