Search of human proteins with 157311649

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157311649 neogenin homolog 1 [Homo sapiens]
         (1461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157311649 neogenin homolog 1 [Homo sapiens]                       2956   0.0  
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]          1424   0.0  
gi|83281200 protogenin [Homo sapiens]                                 287   5e-77
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   272   2e-72
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   271   4e-72
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   268   2e-71
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   266   8e-71
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   260   6e-69
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   254   3e-67
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   248   2e-65
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   247   7e-65
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   244   3e-64
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   244   4e-64
gi|222352127 sidekick 2 [Homo sapiens]                                243   1e-63
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...   241   5e-63
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   237   7e-62
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   236   9e-62
gi|119220552 sidekick 1 [Homo sapiens]                                230   9e-60
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   229   2e-59
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   229   2e-59
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   229   2e-59
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   229   2e-59
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            228   4e-59
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   226   1e-58
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     223   1e-57
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      223   1e-57
gi|75709184 contactin 3 [Homo sapiens]                                220   7e-57
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    218   3e-56
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    218   3e-56
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   218   3e-56

>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score = 2956 bits (7662), Expect = 0.0
 Identities = 1461/1461 (100%), Positives = 1461/1461 (100%)

Query: 1    MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 60
            MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
Sbjct: 1    MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV 60

Query: 61   DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 120
            DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
Sbjct: 61   DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN 120

Query: 121  KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 180
            KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
Sbjct: 121  KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV 180

Query: 181  PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 240
            PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
Sbjct: 181  PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 240

Query: 241  PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 300
            PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
Sbjct: 241  PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL 300

Query: 301  AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 360
            AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
Sbjct: 301  AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 360

Query: 361  ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
Sbjct: 361  ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420

Query: 421  AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE 480
            AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE
Sbjct: 421  AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE 480

Query: 481  GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPG 540
            GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPG
Sbjct: 481  GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPG 540

Query: 541  PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLK 600
            PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLK
Sbjct: 541  PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLK 600

Query: 601  KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPA 660
            KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPA
Sbjct: 601  KYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPA 660

Query: 661  TQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA 720
            TQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA
Sbjct: 661  TQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA 720

Query: 721  TDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSP 780
            TDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSP
Sbjct: 721  TDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSP 780

Query: 781  HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFV 840
            HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFV
Sbjct: 781  HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFV 840

Query: 841  INAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP 900
            INAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP
Sbjct: 841  INAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP 900

Query: 901  ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKD 960
            ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKD
Sbjct: 901  ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKD 960

Query: 961  VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ 1020
            VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ
Sbjct: 961  VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ 1020

Query: 1021 ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGS 1080
            ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGS
Sbjct: 1021 ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGS 1080

Query: 1081 DYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRA 1140
            DYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRA
Sbjct: 1081 DYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRA 1140

Query: 1141 ACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPV 1200
            ACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPV
Sbjct: 1141 ACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPV 1200

Query: 1201 DNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDN 1260
            DNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDN
Sbjct: 1201 DNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDN 1260

Query: 1261 PHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC 1320
            PHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC
Sbjct: 1261 PHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC 1320

Query: 1321 CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALP 1380
            CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALP
Sbjct: 1321 CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALP 1380

Query: 1381 STPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDE 1440
            STPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDE
Sbjct: 1381 STPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDE 1440

Query: 1441 LTKEMAHLEGLMKDLNAITTA 1461
            LTKEMAHLEGLMKDLNAITTA
Sbjct: 1441 LTKEMAHLEGLMKDLNAITTA 1461


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score = 1424 bits (3685), Expect = 0.0
 Identities = 747/1445 (51%), Positives = 1007/1445 (69%), Gaps = 55/1445 (3%)

Query: 41   QSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPS-PKIEWKKDGTFLNLVSDD 99
            Q  G  I+ FT   FL EP D +++RG +V+L+CSA S+   P I+WKKDG  L L  D+
Sbjct: 28   QVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDE 87

Query: 100  RRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPE 159
            R+Q L +GSL I N++HS+H+KPDEG YQC A++   G+IISRTAK+ VAG  RF SQ E
Sbjct: 88   RKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTE 147

Query: 160  PSSVYAGNNAILNCEVNADLVPFVRWEQNRQ---PLLLDDRVIKLPSGMLVISNATEGDG 216
              + + G+  +L CEV  + +P + W++N+Q   P+  D RV+ LPSG L IS    GD 
Sbjct: 148  SVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI 207

Query: 217  GLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
            G+YRC   +    +  +E E+++L DP +   L FL++PS +V + G+D VL C  SG P
Sbjct: 208  GIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYP 267

Query: 277  TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
             P+  W++ EE +   S ++  LL G +L IS+VT+DD+G Y C+    NE I A AELT
Sbjct: 268  PPSFTWLRGEEVIQLRS-KKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELT 326

Query: 337  VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ 396
            V   P FL  P+N+YA+ESMDI FEC V+GKP PTV W+KNGD+VIPSDYF+IV   NL+
Sbjct: 327  VLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLR 386

Query: 397  VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIK 456
            +LG+VKSDEGFYQC+AEN+ GNAQ  AQLI+ + A  ++  LPSAPRDVV  LVS+RF++
Sbjct: 387  ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446

Query: 457  LTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQ 516
            L+WR PA +  G+  T++VF+++EG  RER  NT+ PG +Q+T+ NL P  +Y FRV+A 
Sbjct: 447  LSWRPPA-EAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAY 505

Query: 517  NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYY 576
            N+ G GESS P++V TQPE+Q+PGP  NL+A + SPTSI +TWE P   NG +Q Y+L+ 
Sbjct: 506  NEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFC 565

Query: 577  MEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAA 636
             E  T KEQ+++V   SY + GLKK+TEYS R +AYN++GPGVST D+ V TLSDVPSA 
Sbjct: 566  TEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAP 625

Query: 637  PQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLI 696
            PQN+SLEV NS+SI + W PP   TQNG ITGYKIR+RK +R+ ++ ETL     L  L 
Sbjct: 626  PQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM-ETL-EPNNLWYLF 683

Query: 697  EGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVV 756
             GL++G++Y+F+V+A+T+NGTGP ++W +AET E+DLDE++VP+ PSSLHVRP    I++
Sbjct: 684  TGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIM 743

Query: 757  SWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVG 816
            SWTPP N NIVVRGY IGYG+GSP+A+T++VD KQRYY+IE L+ SSHYVI+LKAFNN G
Sbjct: 744  SWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAG 803

Query: 817  EGIPLYESAVTRPHTD-TSEVDLFVINAPY-TPVPD-PTPMMPPVGVQASILSHDTIRIT 873
            EG+PLYESA TR  TD T  VD + +   + T VPD  TPM+PPVGVQA  L+HD +R++
Sbjct: 804  EGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVS 863

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT 933
            WADNS+PK+QK ++ R YTVRW+T+  A+ KYK+ + T+LSY  TGLKPNT+YEFSVMVT
Sbjct: 864  WADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVT 923

Query: 934  KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIY 993
            K RRSSTWSMTAH TT+E  PTS PKD+TV+++EGKP+ +IV+WQPP EANGKIT YI++
Sbjct: 924  KNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILF 983

Query: 994  YSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
            Y+ D N  I DW++E + G+RLTHQI +L LDT YYF+IQARNSKG+GP+S+ + FRT K
Sbjct: 984  YTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLK 1043

Query: 1054 ADSSDKMPNDQA-SGSGG---KGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVII 1109
             +  DKM NDQ   G GG     + L D  +  +PP+   + PHGS T   +SN+L++I+
Sbjct: 1044 VEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIV 1103

Query: 1110 VSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHER 1169
            V+VGVIT++VVVI+AV CTRR+++ Q+KKRA     + + K KG+ KD++PPDLWIHHE 
Sbjct: 1104 VTVGVITVLVVVIVAVICTRRSSAQQRKKRA----THSAGKRKGSQKDLRPPDLWIHHEE 1159

Query: 1170 LELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSM-DSNIHQRRNSYRGHESED---SMS 1225
            +E+K I+K    +P   D+PI ++ QD+TPV +S  ++ +  +  S+ G ++E+   SMS
Sbjct: 1160 MEMKNIEKPSGTDPAGRDSPI-QSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMS 1218

Query: 1226 T----LAGRRGMRPKMMMPFDSQPPQP-VISAHPIHSLDNPHHHFHSSSLASPARSHLYH 1280
            T    LA RR  R K+M+P D+Q   P V+SA P+ +L++     +   L SP   +  H
Sbjct: 1219 TLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ---YPGILPSPTCGY-PH 1274

Query: 1281 PG---SPWPIGT-SMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYL 1336
            P     P P  T S+     A  ++SV   P+T               Q P     S   
Sbjct: 1275 PQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTT---------------QQPPMLPPSQPE 1319

Query: 1337 ASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHS 1396
             SS EE   +++PTA VRP+HPL+SFA P +PPP     +P +P TPLLSQ         
Sbjct: 1320 HSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPP-MSAIEPKVPYTPLLSQPGPTLPKTH 1378

Query: 1397 VKTASIGTLGRSRPP-MPVVVPSAPEV-QETTRMLEDSESSYEPDELTKEMAHLEGLMKD 1454
            VKTAS+G  G++R P +PV VP+APEV +E+ +  EDS + YE D+L+++MA LEGLMK 
Sbjct: 1379 VKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQ 1438

Query: 1455 LNAIT 1459
            LNAIT
Sbjct: 1439 LNAIT 1443


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score =  287 bits (735), Expect = 5e-77
 Identities = 238/858 (27%), Positives = 399/858 (46%), Gaps = 70/858 (8%)

Query: 42  SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
           SP   +  F+   F+ EP D    R   V+L+C A+ E   K+ W K+G  ++   + R 
Sbjct: 28  SPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMS--ENKRI 85

Query: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
           ++L +GSL+IS V   +  + DEG+YQC+A +   G I+S+ A L ++ +  F  QP  +
Sbjct: 86  EVLSNGSLYISEVEGRRGEQSDEGFYQCLA-MNKYGAILSQKAHLALSTISAFEVQPIST 144

Query: 162 SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-DRVIKLPSGMLVISNATEGDGGLYR 220
            V+ G  A   C++++     + WE NR  L +  DR+  LP+G+L I + ++ D G YR
Sbjct: 145 EVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYR 204

Query: 221 CVVESGGPPKYSDEVELKVLPDPEVIS--DLVFLKQPSPLVRVIGQDVVLPCVASGLPTP 278
           C+  +    + S E  L V+P  E  S      +  P  +   + Q VVL C+A+G P P
Sbjct: 205 CIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264

Query: 279 TIKWMK-NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG---NETIEAQAE 334
            I W + + +++D  ++    +L  G+L ISDV    AG Y C A      N T+ A A 
Sbjct: 265 IISWSRLDHKSIDVFNTR---VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTV-AMAT 320

Query: 335 LTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN 394
           LTV A P F++ P ++    +    F C+  G P+P + W+KNG  +  +   K+     
Sbjct: 321 LTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNS-K 379

Query: 395 LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRF 454
           L +  ++  D+  YQC+AEN  G+  + A+L ++      +   PSAP +V A  +S+  
Sbjct: 380 LVINQIIPEDDAIYQCMAENSQGSILSRARLTVV-----MSEDRPSAPYNVHAETMSSSA 434

Query: 455 IKLTWRTPASDPHGDNLTYSVFYTK-EGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
           I L W  P  +     + YSV Y K EG+  E  +           I +L PA+ Y F +
Sbjct: 435 ILLAWERPLYN-SDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYI 493

Query: 514 MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG---NGEIQ 570
           +A    G+ + S  +   T  +V L  P  +L   + SPT I ++W  P+      G++ 
Sbjct: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPPEISLT--SRSPTDILISW-LPIPAKYRRGQVV 550

Query: 571 NYKLYYMEKGTDKEQDVDV--SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT 628
            Y+L +     +  Q +++  ++H Y + GLK  + Y  R+ A  + G G S+   + RT
Sbjct: 551 LYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRT 610

Query: 629 LSDVPSAAPQN--LSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL 686
                  AP++  L LE  N  +I + WQ     T    I GYK+ Y++  ++ +     
Sbjct: 611 PKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKEEGQQEN-GPIF 667

Query: 687 VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
           +    L   + GLD   +Y+ R+ A      G   D   +      + +  VP  P   H
Sbjct: 668 LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHH 727

Query: 747 VRPLV---TSIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQ-TIKVDYKQRYYTIENLDP 801
           +       +SI + W  P      +  Y I    +G  +A   + +   + +  ++ L+P
Sbjct: 728 LYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEP 787

Query: 802 SSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVP-----DPTPMMP 856
           ++                  YE AV R H D        +++P++PV         P  P
Sbjct: 788 NTK-----------------YEFAV-RLHVDQ-------LSSPWSPVVYHSTLPEAPAGP 822

Query: 857 PVGVQASILSHDTIRITW 874
           PVGV+ +++  DT  ++W
Sbjct: 823 PVGVKVTLIEDDTALVSW 840



 Score =  250 bits (638), Expect = 8e-66
 Identities = 258/1028 (25%), Positives = 416/1028 (40%), Gaps = 109/1028 (10%)

Query: 154  FTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT- 212
            F  +P+  +V   +  +L+C+ + ++   V W +N   +  + R+  L +G L IS    
Sbjct: 41   FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEG 100

Query: 213  ----EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVL 268
                + D G Y+C+  +    KY   +  K       IS   F  QP       G     
Sbjct: 101  RRGEQSDEGFYQCLAMN----KYGAILSQKAHLALSTIS--AFEVQPISTEVHEGGVARF 154

Query: 269  PCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN-GNE 327
             C  S  P   I W  N   L   + +R+  L  G L+I DV++ D+G Y CIA    + 
Sbjct: 155  ACKISSHPPAVITWEFNRTTLPM-TMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHR 213

Query: 328  TIEAQAELTVQAQ--------PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
                +A LTV           P  +  P NI       +V EC  TG P P + W +   
Sbjct: 214  RKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDH 273

Query: 380  MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP 439
              I     +++   NL +  +     G Y C A          A   +   AP +    P
Sbjct: 274  KSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWP 333

Query: 440  SA---PRDVVASLVSTR----FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSH 492
             +   PR   A  V         K++W       H +              R ++ N+  
Sbjct: 334  ESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNG-------------RIKMYNS-- 378

Query: 493  PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
                ++ I  ++P    I++ MA+N  GS  S A L V    +   P    N+ A   S 
Sbjct: 379  ----KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSS 432

Query: 553  TSITVTWETPVSGNGEIQNYKLYYME-KGTDKEQDVDVSSHS---YTINGLKKYTEYSFR 608
            ++I + WE P+  + ++  Y ++YM+ +G + E+   V  +    Y I+ L+  + Y+F 
Sbjct: 433  SAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFY 492

Query: 609  VVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITG 668
            +VAY   G    +  V   TL DVP   P+ +SL  R+   I+I W P     + GQ+  
Sbjct: 493  IVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVL 551

Query: 669  YKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAET 728
            Y++ +R ++  S +    + GT    L+EGL   + Y  R+ A T  G G ++ W S  T
Sbjct: 552  YRLSFRLSTENS-IQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRT 610

Query: 729  FESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIGYGI-GSPHAQTIK 786
             ++     + P+ P  LH+ PL  T+I V W         ++GY + Y   G      I 
Sbjct: 611  PKAT--SVKAPKSPE-LHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIF 667

Query: 787  VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
            +D K   YT+  LDP   Y + L A+NN+ +G    +  V+ P        + V +    
Sbjct: 668  LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQTVSTPGC------VSVRDRMVP 720

Query: 847  PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTK-- 904
            P P P  +       +SI  H      W   +    Q I     YT+R       N    
Sbjct: 721  PPPPPHHLYAKANTSSSIFLH------WRRPAFTAAQIIN----YTIRCNPVGLQNASLV 770

Query: 905  -YKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTV 963
             Y   + T +  LV GL+PNT YEF+V +   + SS WS   + +T    P  PP  V V
Sbjct: 771  LYLQTSETHM--LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKV 828

Query: 964  VSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT 1023
               E    T +V+W+PP      +T Y I Y++       +W +    G      ++ L 
Sbjct: 829  TLIE--DDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLV 886

Query: 1024 LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYK 1083
                Y  KI A N  G GP S +V+      ++S+                     S+ +
Sbjct: 887  AGNVYIVKISASNEVGEGPFSNSVELAVLPKETSE---------------------SNQR 925

Query: 1084 PP-MSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAAC 1142
            P  +  +++   S    LD   +  I V VG+    +++ + +   R   S  +K  A+ 
Sbjct: 926  PKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYR---SKARKSSASK 982

Query: 1143 KSVNGSHK 1150
             + NG+ +
Sbjct: 983  TAQNGTQQ 990



 Score =  129 bits (324), Expect = 2e-29
 Identities = 187/846 (22%), Positives = 332/846 (39%), Gaps = 89/846 (10%)

Query: 237  LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSER 296
            L  LP     S+L F+K+P  +       VVL C A G     + W+KN   +    ++R
Sbjct: 27   LSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM--SENKR 84

Query: 297  LVLLAGGSLEISDV-----TEDDAGTYFCIADNGNETIEAQ-AELTVQAQPEFLKQPTNI 350
            + +L+ GSL IS+V      + D G Y C+A N    I +Q A L +     F  QP + 
Sbjct: 85   IEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPIST 144

Query: 351  YAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQ 409
              HE     F C+++  P   + W  N   + +  D    +    LQ+  + + D G Y+
Sbjct: 145  EVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYR 204

Query: 410  CIAENDVGNAQA-GAQLIIL---EHAPATTGPLPSAPRDVVASLVSTRFIK-LTWRTP-- 462
            CIA       ++  A L ++   E     T  + + P+++  SL  T  ++ +    P  
Sbjct: 205  CIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264

Query: 463  -ASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGS 521
              S    D+ +  VF T+              G + ++   L  A VY+ R         
Sbjct: 265  IISWSRLDHKSIDVFNTR----------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNF 314

Query: 522  GESSAPLRVETQPE-VQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 580
              + A L V   P  V+ P            P + T  +     G   I + K+ +++ G
Sbjct: 315  TVAMATLTVLAPPSFVEWP-------ESLTRPRAGTARFVCQAEG---IPSPKMSWLKNG 364

Query: 581  TDKEQD--VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQ 638
                 +  + + +    IN +    +  ++ +A N  G  +S   + V    D PS AP 
Sbjct: 365  RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS-APY 423

Query: 639  NLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQ-LIE 697
            N+  E  +S +I++ W+   P   + ++  Y + Y KA   ++    +V G   +  +I+
Sbjct: 424  NVHAETMSSSAILLAWE--RPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID 481

Query: 698  GLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVS 757
             L+  + Y F + A    G    +D ++  T E      R PE+  SL  R   T I++S
Sbjct: 482  DLEPASNYTFYIVAYMPMGASQMSDHVTQNTLED--VPLRPPEI--SLTSRS-PTDILIS 536

Query: 758  W--TPPENQNIVVRGYAIGYGIGSPHA-QTIKVDYKQRYYTIENLDPSSHYVITLKAFNN 814
            W   P + +   V  Y + + + + ++ Q +++      Y +E L P S Y++ + A   
Sbjct: 537  WLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATR 596

Query: 815  VGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITW 874
            VG G    ES+V   H          + AP +P     P           L+  TI + W
Sbjct: 597  VGLG----ESSVWTSHRTPKATS---VKAPKSPELHLEP-----------LNCTTISVRW 638

Query: 875  ADNSLPKHQKITDS---RYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVM 931
                    Q + D+   + Y + +K            +   L Y ++GL P   Y   ++
Sbjct: 639  -------QQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLL 691

Query: 932  VTKG-----RRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGK 986
                     +   T S     +  + +   PP    + +K     +I ++W+ P+    +
Sbjct: 692  AYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQ 751

Query: 987  ITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQ-IQELTLDTPYYFKIQARNSKGMGPMSE 1045
            I  Y I  +      + +  +   +    TH  +Q L  +T Y F ++    +   P S 
Sbjct: 752  IINYTIRCNP---VGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSP 808

Query: 1046 AVQFRT 1051
             V   T
Sbjct: 809  VVYHST 814


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  272 bits (696), Expect = 2e-72
 Identities = 291/1072 (27%), Positives = 454/1072 (42%), Gaps = 156/1072 (14%)

Query: 51   TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP--DGS 108
            TP  F   PVD   V G      C A  +P PKI W K G     VS+ R +++   DGS
Sbjct: 22   TPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKG---KKVSNQRFEVIEFDDGS 78

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA------GLPRFTSQPEPSS 162
              +  +   +  + DE  Y+CVA+  ++G I   T   ++       G P     P+   
Sbjct: 79   GSVLRIQPLRTPR-DEAIYECVAS-NNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136

Query: 163  VYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDD---RVIKLPSGMLVISNATEGDGGLY 219
            V     A + C  + +  P + W ++  P+   +   R+ +L SG L I  + E D G Y
Sbjct: 137  VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKY 196

Query: 220  RCVVESGGPPKYSDEVELKV----LPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGL 275
             CV  +    +YS    L V    +P         F   P+    + G  V + CVA G 
Sbjct: 197  ECVATNSAGTRYSAPANLYVRVRRVPPR-------FSIPPTNHEIMPGGSVNITCVAVGS 249

Query: 276  PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAEL 335
            P P +KWM   E L  E     + +    LE++DV +  +  Y C+A +    IEA A++
Sbjct: 250  PMPYVKWMLGAEDLTPEDD---MPIGRNVLELNDVRQ--SANYTCVAMSTLGVIEAIAQI 304

Query: 336  TVQAQPEFLKQP-TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKI---VK 391
            TV+A P   K P T +    +   +     +G P P   ++         + +K    V 
Sbjct: 305  TVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVA 361

Query: 392  EHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASL 449
                 V GL    +  ++ +A N++G       ++    E AP+      SAPRDV A +
Sbjct: 362  TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS------SAPRDVQARM 415

Query: 450  VSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT-IQNLMPATV 508
            +S+  I + W+ P  +P+G    Y V+YT +           +  + Q+T I NL+P   
Sbjct: 416  LSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKT 474

Query: 509  YIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGE 568
            Y  +V+A    G G  S+ ++V TQ  V  PG   N +A   S TSI ++W  P S    
Sbjct: 475  YSVKVLAFTSIGDGPLSSDIQVITQTGV--PGQPLNFKAEPESETSILLSWTPPRSDT-- 530

Query: 569  IQNYKLYYMEKGTDKEQDVDVS-SHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
            I NY+L Y +    +EQ + +    SY + GLK  + Y FR+ A +  G G ST +++ R
Sbjct: 531  IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 590

Query: 628  TLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL- 686
            T+   PSA PQ++S    +S SI++ WQPP    QNG IT Y I+Y     + D    + 
Sbjct: 591  TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 650

Query: 687  -VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPE-VPSS 744
             +       L+E L++ TEY   V A T  G GP +  +   T E       VP   P  
Sbjct: 651  GIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED------VPSGPPRK 704

Query: 745  LHVRPL-VTSIVVSWTPP--ENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDP 801
            + V  +  TS+ VSW  P    Q+  +RG                  Y+  Y  +EN +P
Sbjct: 705  VEVEAVNSTSVKVSWRSPVPNKQHGQIRG------------------YQVHYVRMENGEP 746

Query: 802  SSHYVITLKAFNNVGEGIPLYESAVTRP----HTDTSEVDLFVINAPYTPVPDPTPMMPP 857
                           +G P+ +  +         DT+E D+ +           + + P 
Sbjct: 747  ---------------KGQPMLKDVMLADAQWEFDDTTEHDMII-----------SGLQPE 780

Query: 858  VGVQASILSHDTI--------RITWADNSLPKHQKI----TDSRYYTVRWKTNIPANTKY 905
                 ++ ++ T         ++     ++P   ++    T      ++W    P +T +
Sbjct: 781  TSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP--PVDT-F 837

Query: 906  KNANATTLSYLVTGLKPNTLYEFSVM--------VTKGR----RSSTWSMTAHGTTF--- 950
                   L +    ++P T  EFS          + KG     R S  +    G      
Sbjct: 838  GPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKE 897

Query: 951  ----ELVPTSPPKDVTVVSKEGKPKTII-VNWQPP--SEANGKITGYIIYYSTDVNAEIH 1003
                E VPT  P+++     EG   T + ++WQPP  +E NG IT Y + Y  D+N  + 
Sbjct: 898  ISIPEEVPTGFPQNL---HSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINIPLL 953

Query: 1004 DWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKAD 1055
              + + +V    T  +  L  DT Y  K++A  SKG GP S +VQFRT   D
Sbjct: 954  P-MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1004



 Score =  201 bits (511), Expect = 4e-51
 Identities = 228/1018 (22%), Positives = 399/1018 (39%), Gaps = 117/1018 (11%)

Query: 66   RGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR-QLLPDGSLFISNVVHSKHNKPDE 124
            R  +  + C+A   P P+I W KD   ++  +++ R + L  G+L I     S     D+
Sbjct: 139  RTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEES-----DQ 193

Query: 125  GYYQCVATVESLGTIISRTAKLIVAGL---PRFTSQPEPSSVYAGNNAILNCEVNADLVP 181
            G Y+CVAT  S GT  S  A L V      PRF+  P    +  G +  + C      +P
Sbjct: 194  GKYECVAT-NSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMP 252

Query: 182  FVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPPKYSDEVELKVL 240
            +V+W    + L  +D    +P G  V+          Y CV  S  G  +   ++ +K L
Sbjct: 253  YVKWMLGAEDLTPED---DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 309

Query: 241  PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-----KNEEALDTESSE 295
            P P            +P+V       +     SG P P   ++     KN E L  E   
Sbjct: 310  PKPP----------GTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDG 359

Query: 296  RLVLLAGGSLEISDVTEDDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQPTNIYAH- 353
                +A     ++ ++      +  +A N       ++  LT  ++      P ++ A  
Sbjct: 360  ----VATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 415

Query: 354  -ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ------VLGLVKSDEG 406
              S  I+ + +   +P   ++  +    + P+ +     +HN+       +  LV     
Sbjct: 416  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 475

Query: 407  FYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466
              + +A   +G+    + + ++     T   +P  P +  A   S   I L+W  P SD 
Sbjct: 476  SVKVLAFTSIGDGPLSSDIQVI-----TQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 530

Query: 467  HGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526
              +   Y + Y K+G   E    T  PG     +Q L P ++Y FR+ A++  G G S+A
Sbjct: 531  IAN---YELVY-KDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGASTA 585

Query: 527  PLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGTDKE 584
             +   T  + +   P  ++   + S TSI V+W+ P     NG I  Y + Y     D E
Sbjct: 586  EISARTM-QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYT--AVDGE 642

Query: 585  QD-------VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAP 637
             D       +   +  Y +  L+K+TEY   V A+   GPG  +  V +RT  DVPS  P
Sbjct: 643  DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 702

Query: 638  QNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLS---- 693
            + + +E  NS S+ + W+ P P  Q+GQI GY++ Y +        + ++    L+    
Sbjct: 703  RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 762

Query: 694  ---------QLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSS 744
                      +I GL   T Y+  V A T  G G  +      T  +      VP  P  
Sbjct: 763  EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA------VPGKPRL 816

Query: 745  LHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPH-AQTIKVDYKQRYYTIENLDPSS 803
            +     + + ++ W PP +    ++GY + +G        T++   K+ ++T  ++   +
Sbjct: 817  VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGA 876

Query: 804  HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQAS 863
             YV  L A N VG G  + +                        +P+  P   P  + + 
Sbjct: 877  SYVFRLSARNKVGFGEEMVKE---------------------ISIPEEVPTGFPQNLHSE 915

Query: 864  ILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPN 923
              +  +++++W    L +   I  ++Y  +    NIP     +       +  +TGLKP+
Sbjct: 916  GTTSTSVQLSWQPPVLAERNGII-TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPD 974

Query: 924  TLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEA 983
            T Y+  V     +    +S +     F  +P           K     +++++W+ P   
Sbjct: 975  TTYDVKVRAHTSKGPGPYSPSVQ---FRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENY 1031

Query: 984  NGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMG 1041
            N  +   I+Y            ++E V G      I  L  +  Y F +  R +   G
Sbjct: 1032 NSAMPFKILYDDGK--------MVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGG 1081



 Score =  123 bits (309), Expect = 1e-27
 Identities = 166/746 (22%), Positives = 285/746 (38%), Gaps = 105/746 (14%)

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN--- 394
            +  P F + P +          F C+ TG P P + W K G  V  +  F++++  +   
Sbjct: 21   ETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV-SNQRFEVIEFDDGSG 79

Query: 395  --LQVLGL-VKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASL 449
              L++  L    DE  Y+C+A N+VG      +L +L  +  P     +   P+  V   
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 450  VSTRFI----------KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
              T  +          ++TW          N    +   + G  +      S  G+ +  
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199

Query: 500  IQNLM------PATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT 553
              N        PA +Y+     + +      S P    T  E+ +PG + N+   A    
Sbjct: 200  ATNSAGTRYSAPANLYV-----RVRRVPPRFSIP---PTNHEI-MPGGSVNITCVAVGSP 250

Query: 554  SITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYN 613
               V W                   +    E D+ +  +   +N +++   Y+   VA +
Sbjct: 251  MPYVKWMLGA---------------EDLTPEDDMPIGRNVLELNDVRQSANYT--CVAMS 293

Query: 614  KHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRY 673
              G   +   + V+ L   P       S     + SI + W      + N +   Y I  
Sbjct: 294  TLGVIEAIAQITVKALPKPPGTPVVTES----TATSITLTWD-----SGNPEPVSYYIIQ 344

Query: 674  RKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDL 733
             K     ++ + +         + GL   ++Y FRV A+   G GP ++ +  +T     
Sbjct: 345  HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT----- 399

Query: 734  DETRVPEVPSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYK-- 790
             E      P  +  R L  T+I+V W  PE  N  ++GY + Y +         + +   
Sbjct: 400  SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA 459

Query: 791  -QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVP 849
              +  TI NL P   Y + + AF ++G+G PL               D+ VI    T VP
Sbjct: 460  DSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSS-------------DIQVITQ--TGVP 503

Query: 850  DPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNAN 909
                   P+  +A   S  +I ++W     P+   I +   Y + +K       +     
Sbjct: 504  GQ-----PLNFKAEPESETSILLSWTP---PRSDTIAN---YELVYKDGEHGEEQRITIE 552

Query: 910  ATTLSYLVTGLKPNTLYEFSVMVT--KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKE 967
              T SY + GLKPN+LY F +     +G  +ST  ++A   T +  P++PP+D++  S  
Sbjct: 553  PGT-SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR--TMQSKPSAPPQDISCTSPS 609

Query: 968  GKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLD 1025
                +I+V+WQPP   + NG IT Y I Y+     +     I  +  +   + +++L   
Sbjct: 610  ST--SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667

Query: 1026 TPYYFKIQARNSKGMGPMSEAVQFRT 1051
            T Y   + A    G GP S +V  RT
Sbjct: 668  TEYRITVTAHTDVGPGPESLSVLIRT 693



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 69/266 (25%), Positives = 106/266 (39%), Gaps = 35/266 (13%)

Query: 794  YTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTP 853
            Y++  L P S Y   + A NN+G G P             SE  L       T   +  P
Sbjct: 365  YSVAGLSPYSDYEFRVVAVNNIGRGPP-------------SEPVL-------TQTSEQAP 404

Query: 854  MMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANA--T 911
               P  VQA +LS  TI + W +   P  Q      YYT+    ++    K+  A++  T
Sbjct: 405  SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 464

Query: 912  TLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPK 971
            T+  LV    P   Y   V+          S      T   VP  P   +   ++     
Sbjct: 465  TIGNLV----PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP---LNFKAEPESET 517

Query: 972  TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFK 1031
            +I+++W PP   +  I  Y + Y    + E     IEP    RL    Q L  ++ YYF+
Sbjct: 518  SILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRL----QGLKPNSLYYFR 571

Query: 1032 IQARNSKGMGPMSEAVQFRTPKADSS 1057
            + AR+ +G+G  +  +  RT ++  S
Sbjct: 572  LAARSPQGLGASTAEISARTMQSKPS 597


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo
            sapiens]
          Length = 1250

 Score =  271 bits (692), Expect = 4e-72
 Identities = 261/959 (27%), Positives = 393/959 (40%), Gaps = 113/959 (11%)

Query: 169  AILNCEVNADLV---PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG--------- 216
            A+LNC + A        V W ++   LL  D +  LP+G L +S     +G         
Sbjct: 53   AVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAV 112

Query: 217  ----GLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC 270
                G Y C+     G     +  V+L  L D        F   P              C
Sbjct: 113  GVIEGNYSCLAHGPLGVLASQTAVVKLATLAD--------FSLHPESQTVEENGTARFEC 164

Query: 271  VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE 330
               GLP P I W K++  L  E   RL++L  G L+I DV E DAG Y C+A N      
Sbjct: 165  HIEGLPAPIITWEKDQVTLPEEP--RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHF 222

Query: 331  AQAELTVQAQPEFLKQ-----------PTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
            +Q  L   A    L             P N        +V EC  +  PTP V WV+   
Sbjct: 223  SQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDG 282

Query: 380  MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN--AQAGAQLIILEHAPATTGP 437
              I +D   ++   NL +        G Y C A        A A A+L +L  APA T  
Sbjct: 283  KPISTDVI-VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA-APAIT-- 338

Query: 438  LPSAPRDVVASLVST-RFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE---RVENTSHP 493
               AP  +  +  ST RF+      P           ++ +   G       RV+     
Sbjct: 339  --QAPEALSRTRASTARFVCRASGEPRP---------ALRWLHNGAPLRPNGRVKVQGGG 387

Query: 494  GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT 553
            G + +T   L  A  Y  + +A+N  G   ++A L V  +    LP     + A   S +
Sbjct: 388  GSLVITQIGLQDAGYY--QCVAENSAGMACAAASLAVVVREG--LPSAPTRVTATPLSSS 443

Query: 554  SITVTWETPVSGNGEIQNYKLYYME-KGTDKEQ---DVDVSSHSYTINGLKKYTEYSFRV 609
            ++ V WE P   + +I  + L+Y + +G D  +    V+  +    +  L+  T+Y F V
Sbjct: 444  AVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYV 503

Query: 610  VAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 669
            VAY++ G   ++    V TL DVPSAAPQ LSL   N   I + W P  P+  NGQ+  Y
Sbjct: 504  VAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKY 562

Query: 670  KIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETF 729
            KI Y    ++  +  T V G +   ++  L     Y  R++A T  G G  + W+   T 
Sbjct: 563  KIEYG-LGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT- 620

Query: 730  ESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAI---------------- 773
             S  +++ VP  P+ L V+  + S+VVSW PP +    + GY +                
Sbjct: 621  PSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRL 679

Query: 774  --GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHT 831
              G G  +     +++  K + Y +  L P   Y + L AFN   +G     +AV +  T
Sbjct: 680  PGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGY----AAVWKGKT 735

Query: 832  DTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYY 891
            + +        AP  P+    P+ PP  V A   S  +I + W        + +     Y
Sbjct: 736  EKAP-------APDMPIQRGPPL-PPAHVHAESNSSTSIWLRWKKPDFTTVKIVN----Y 783

Query: 892  TVR---WKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGT 948
            TVR   W     +   Y  ++   +  L+ GLKP T YEF+V          +      +
Sbjct: 784  TVRFSPWGLRNASLVTYYTSSGEDI--LIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841

Query: 949  TFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIE 1008
            T    P++PP D+ +      P T+ ++W PP+E NG+I  Y+I YS++     H W + 
Sbjct: 842  TLPDRPSTPPSDLRLSPLT--PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLL 899

Query: 1009 PVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASG 1067
               GN  + ++  L  DT Y+FK+ AR   G GP S      T +   SD +     +G
Sbjct: 900  TTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTG 958



 Score =  255 bits (652), Expect = 2e-67
 Identities = 251/932 (26%), Positives = 409/932 (43%), Gaps = 106/932 (11%)

Query: 57  VEPVDTLSVRGSSVILNCS---AYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISN 113
           V P+  +     + +LNCS   A + P  ++ W KDG    L+  D   LLP+GSL++S 
Sbjct: 40  VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGD--TLLEHDHLHLLPNGSLWLSQ 97

Query: 114 VVH---SKHNKPD-----EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165
            +    S  + P+     EG Y C+A    LG + S+TA + +A L  F+  PE  +V  
Sbjct: 98  PLAPNGSDESVPEAVGVIEGNYSCLAH-GPLGVLASQTAVVKLATLADFSLHPESQTVEE 156

Query: 166 GNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVES 225
              A   C +     P + WE+++  L  + R+I LP+G+L I +  E D G YRCV  +
Sbjct: 157 NGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATN 216

Query: 226 GGPPKYSDEVELKVLPDPEVIS----DLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIK 281
                +S E  L V     + S    D+V +  P     V GQ VV+ CVAS  PTP + 
Sbjct: 217 SARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVS 276

Query: 282 WMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELTVQA 339
           W++ +       S  +++L   +L I++     +G Y C A+     +   A AEL V A
Sbjct: 277 WVRQD---GKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333

Query: 340 QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIV-KEHNLQVL 398
            P   + P  +    +    F C  +G+P P ++W+ NG  + P+   K+     +L + 
Sbjct: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVIT 393

Query: 399 GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
            +   D G+YQC+AEN  G A A A L ++         LPSAP  V A+ +S+  + + 
Sbjct: 394 QIGLQDAGYYQCVAENSAGMACAAASLAVV-----VREGLPSAPTRVTATPLSSSAVLVA 448

Query: 459 WRTPASDPHGDNLT-YSVFYTK-EGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQ 516
           W  P  + H + +  +S+ Y K  G+     +   +    ++ +++L P T Y F V+A 
Sbjct: 449 WERP--EMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAY 506

Query: 517 NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKL 574
           ++ G+  +S P  V T  +V  P  AP L   + +P+ I V W    P   NG++  YK+
Sbjct: 507 SQLGASRTSTPALVHTLDDV--PSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKI 564

Query: 575 YYMEKGTDKEQ-----DVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT- 628
            Y   G  KE      +V  +     +N L+    Y  R+ A    G G  +  +  RT 
Sbjct: 565 EY---GLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTP 621

Query: 629 ----LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE 684
                S VP  AP  L ++ +  +S+++ WQPP   T   QI+GYK+ +R+   + +   
Sbjct: 622 SMHNQSHVP-FAPAELKVQAK-MESLVVSWQPPPHPT---QISGYKLYWREVGAEEEANG 676

Query: 685 TLVSGTQLSQL----------------IEGLDRGTEYNFRVAALTINGTGPATDW--LSA 726
             + G +  Q                 +  L  G  Y  ++ A   +  G A  W   + 
Sbjct: 677 DRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTE 736

Query: 727 ETFESDLDETRVPEVPSSLHVRP---LVTSIVVSWTPPENQNIVVRGYAIGYG-IGSPHA 782
           +    D+   R P +P + HV       TSI + W  P+   + +  Y + +   G  +A
Sbjct: 737 KAPAPDMPIQRGPPLPPA-HVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNA 795

Query: 783 QTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVIN 842
             +       YYT    D     +  LK F         YE AV     D       V+ 
Sbjct: 796 SLV------TYYTSSGED---ILIGGLKPFTK-------YEFAVQSHGVDMDGPFGSVVE 839

Query: 843 APYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPAN 902
              + +PD  P  PP  ++ S L+  T+R+ W   + P  + +     Y + + +N    
Sbjct: 840 R--STLPD-RPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVE----YLILYSSN-HTQ 891

Query: 903 TKYKNANATT----LSYLVTGLKPNTLYEFSV 930
            +++    TT     S  V GL+ +T Y F +
Sbjct: 892 PEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923



 Score =  171 bits (433), Expect = 5e-42
 Identities = 215/857 (25%), Positives = 335/857 (39%), Gaps = 136/857 (15%)

Query: 42  SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
           S  A ++  T   F + P         +    C     P+P I W+KD   + L  + R 
Sbjct: 132 SQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQ--VTLPEEPRL 189

Query: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTS----- 156
            +LP+G L I +V  S     D G Y+CVAT  S     S+ A L VA      S     
Sbjct: 190 IVLPNGVLQILDVQES-----DAGPYRCVAT-NSARQHFSQEALLSVAHRGSLASTRGQD 243

Query: 157 -----QPEPSSVYAGNNAILNCEVNADLVPFVRW-EQNRQPLLLDDRVIKLPSGMLVISN 210
                 PE ++V +G + ++ C  +AD  PFV W  Q+ +P+  D  VI L    L+I+N
Sbjct: 244 VVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLLIAN 301

Query: 211 ATEGDGGLYRCVVESGGPPKYSD----EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDV 266
           A     G+Y C       P+  D      EL+VL  P +       + P  L R      
Sbjct: 302 AQPWHSGVYVC---RANKPRTRDFATAAAELRVLAAPAI------TQAPEALSRTRASTA 352

Query: 267 VLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGN 326
              C ASG P P ++W+ N   L      + V   GGSL I+ +   DAG Y C+A+N  
Sbjct: 353 RFVCRASGEPRPALRWLHNGAPLRPNGRVK-VQGGGGSLVITQIGLQDAGYYQCVAENSA 411

Query: 327 ETIEAQAELTVQAQPEFLKQPTNIYA-----------------HESMDIVFEC---EVTG 366
               A A L V  +      PT + A                 H    I F     +  G
Sbjct: 412 GMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARG 471

Query: 367 KPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLI 426
                 ++  N D               LQV  L  + +  +  +A + +G ++     +
Sbjct: 472 MDNVEYQFAVNNDTT------------ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPAL 519

Query: 427 ILEHAPATTGPLPSAPRDVVASLVSTRFIKLTW-RTPASDPHGDNLTYSVFYTKEGIARE 485
           +      T   +PSA   +  S  +   I++ W   P S  +G  + Y + Y   G+ +E
Sbjct: 520 V-----HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY---GLGKE 571

Query: 486 -RVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP 543
            ++ +T   G E Q+ + +L P  VY  R+ A    G G  S  +   T P +      P
Sbjct: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT-PSMHNQSHVP 630

Query: 544 NLRA---YAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVD------------ 588
              A     A   S+ V+W+ P     +I  YKLY+ E G ++E + D            
Sbjct: 631 FAPAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWD 689

Query: 589 -------VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVS-----------TPDVAVRTLS 630
                       Y +  L     Y  ++VA+NKH  G +            PD+ ++   
Sbjct: 690 VGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGP 749

Query: 631 DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGT 690
            +P   P ++  E  +S SI + W+ P   T   +I  Y +R+     ++    T  + +
Sbjct: 750 PLP---PAHVHAESNSSTSIWLRWKKPDFTTV--KIVNYTVRFSPWGLRNASLVTYYTSS 804

Query: 691 QLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPE----VPSSLH 746
               LI GL   T+Y F V +  ++  GP         F S ++ + +P+     PS L 
Sbjct: 805 GEDILIGGLKPFTKYEFAVQSHGVDMDGP---------FGSVVERSTLPDRPSTPPSDLR 855

Query: 747 VRPLVTSIV-VSWTPPENQNIVVRGYAIGYGIG--SPHAQTIKVDYKQRYYTIE--NLDP 801
           + PL  S V + W PP   N  +  Y I Y      P  Q   +  +   ++ E   L+ 
Sbjct: 856 LSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLES 915

Query: 802 SSHYVITLKAFNNVGEG 818
            + Y   + A   VG G
Sbjct: 916 DTRYFFKMGARTEVGPG 932


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  268 bits (686), Expect = 2e-71
 Identities = 279/1052 (26%), Positives = 432/1052 (41%), Gaps = 128/1052 (12%)

Query: 52   PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
            P  F+ EP D + V G      C A  +P P++ W K G  +N  S     +  D S   
Sbjct: 32   PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN--SQRFETIEFDESAGA 89

Query: 112  SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV-------AGLPRFTSQPEPSSVY 164
               +       DE  Y+CVA   S+G I    AKL V       +G P     P+   V 
Sbjct: 90   VLRIQPLRTPRDENVYECVAQ-NSVGEITVH-AKLTVLREDQLPSGFPNIDMGPQLKVVE 147

Query: 165  AGNNAILNCEVNADLVPFVRWEQNRQPL---LLDDRVIKLPSGMLVISNATEGDGGLYRC 221
                A + C  + +  P + W ++  P+     + R+ +L SG L I ++ E D G Y C
Sbjct: 148  RTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYEC 207

Query: 222  VVESGGPPKYSDEVEL-----KVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
            V  +    +YS    L     +V P   ++        P     + G +V + CVA G P
Sbjct: 208  VATNSAGVRYSSPANLYVRVRRVAPRFSIL--------PMSHEIMPGGNVNITCVAVGSP 259

Query: 277  TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
             P +KWM+  E L  E     + +    LE++DV   D+  Y C+A +    IEA A++T
Sbjct: 260  MPYVKWMQGAEDLTPEDD---MPVGRNVLELTDVK--DSANYTCVAMSSLGVIEAVAQIT 314

Query: 337  VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWV---KNGDMVIPSDYFKIVKEH 393
            V++ P+    P  +  + +  I    + +G P P   +V   K+     P    + +   
Sbjct: 315  VKSLPKAPGTPM-VTENTATSITITWD-SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTT 372

Query: 394  NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASLVS 451
               + GL  + E      A N +G       ++    E APA      SAPR+V A ++S
Sbjct: 373  RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA------SAPRNVQARMLS 426

Query: 452  TRFIKLTWRTPASDPHGDNLTYSVFYTKEG---IARERVENTSHPGEMQVTIQNLMPATV 508
               + + W  P  +P+G    Y V+YT E    +   +  N      +  T+ +L+    
Sbjct: 427  ATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD--SLLTTVGSLLEDET 483

Query: 509  YIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGE 568
            Y  RV+A    G G  S P++V+TQ  V  PG   NLRA A S TSIT++W  P   +  
Sbjct: 484  YTVRVLAFTSVGDGPLSDPIQVKTQQGV--PGQPMNLRAEARSETSITLSWSPPRQES-- 539

Query: 569  IQNYKLYYME--KGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAV 626
            I  Y+L + E   G +  +  D ++ SY +  LK  TEY+FR+ A +  G G  TP V  
Sbjct: 540  IIKYELLFREGDHGREVGRTFDPTT-SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ 598

Query: 627  RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL 686
            RTL   PSA PQ++      S +I++ W+PP P T NG + GY +RYR    +    + +
Sbjct: 599  RTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEV 658

Query: 687  --VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSS 744
              +  T    L+E L++ T+Y     A T  G GP +   S     +D D    P  P  
Sbjct: 659  NGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES---SPVVVRTDEDVPSAP--PRK 713

Query: 745  LHVRPL-VTSIVVSWTPPE--NQNIVVRGYAIGY-------GIGSPHAQTIKVDYKQRYY 794
            +    L  T+I V W  P    Q+  +RGY + Y         G P  + + +   Q   
Sbjct: 714  VEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQE-M 772

Query: 795  TIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPM 854
             I NL P + Y IT+ A+   G+G       V           L V   P          
Sbjct: 773  VITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTP---------- 822

Query: 855  MPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLS 914
                  + S+L+       W   +     ++   R    R  +   A  ++  +      
Sbjct: 823  ------EGSLLAR------WEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSED---R 867

Query: 915  YLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPK---DVTVVSKEGKPK 971
            Y  +G+     Y F +        S   +         +P   P+    +   +      
Sbjct: 868  YTASGVHKGATYVFRLAA-----RSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAG 922

Query: 972  TIIVNWQP--PSEANGKITGYIIYY----------STDVNAEIHDWVIEPVVGNRLTHQI 1019
            T+++ W P  P+E NG I  Y +             T++ A       EP   N LT  +
Sbjct: 923  TVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPA-----AAEPGAENALT--L 975

Query: 1020 QELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
            Q L  DT Y  +++A   +G GP S  V++RT
Sbjct: 976  QGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1007



 Score =  122 bits (307), Expect = 2e-27
 Identities = 114/433 (26%), Positives = 185/433 (42%), Gaps = 40/433 (9%)

Query: 411  IAENDVGNAQAGAQLIILEHAPATTGPLPSAP-RDVVASLVSTRFIKLTWRTPASD-PHG 468
            +A  +VG     + +++      T   +PSAP R V A  ++   I++ WR+PA    HG
Sbjct: 684  VAHTEVGPGPESSPVVV-----RTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738

Query: 469  DNLTYSVFYTK----EGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGES 524
                Y V Y +    E     R+++       ++ I NL P T Y   V A    G G  
Sbjct: 739  QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGAR 798

Query: 525  SAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV-SGNGEIQNYKLYYMEKGTDK 583
            S P  V T+  V      P L        S+   WE P  +   ++  Y+L +  + +  
Sbjct: 799  SKPKVVVTKGAVL---GRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTP 855

Query: 584  EQDVDV--SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLS 641
               ++   S   YT +G+ K   Y FR+ A ++ G G    +V +    D P   PQ L 
Sbjct: 856  LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEV-LSIPEDTPRGHPQILE 914

Query: 642  LEVRNSK-SIMIHWQPPAPATQNGQITGYKIRYRKA-----SRKSDVTETLVSGTQLSQL 695
                 S  ++++ W PP PA +NG I  Y +  R+A     +R++++      G + +  
Sbjct: 915  AAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALT 974

Query: 696  IEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLV-TSI 754
            ++GL   T Y+ +V A T  G GP +  +   TF  D         P +  V+ ++ TS+
Sbjct: 975  LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRD------QVSPKNFKVKMIMKTSV 1028

Query: 755  VVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNN 814
            ++SW  P+N N     Y I Y     +  T+ VD +     I +L P + Y   L    N
Sbjct: 1029 LLSWEFPDNYNSPT-PYKIQY-----NGLTLDVDGRTTKKLITHLKPHTFYNFVL---TN 1079

Query: 815  VGEGIPLYESAVT 827
             G  +   +  VT
Sbjct: 1080 RGSSLGGLQQTVT 1092



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 119/562 (21%), Positives = 212/562 (37%), Gaps = 63/562 (11%)

Query: 505  PATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRA---YAASPTSITVTWET 561
            P    ++  +AQN    GE +   ++    E QLP   PN+           + T T   
Sbjct: 99   PRDENVYECVAQNS--VGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLC 156

Query: 562  PVSGNG--EIQNYKLYY-MEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPG 618
              SGN   EI  +K +  ++      +   + S +  I   ++  +  +  VA N  G  
Sbjct: 157  AASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVR 216

Query: 619  VSTP-DVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKAS 677
             S+P ++ VR     P  +   +S E+    ++ I           G    Y +++ + +
Sbjct: 217  YSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNI------TCVAVGSPMPY-VKWMQGA 269

Query: 678  RKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETR 737
                  + +  G  + +L +  D     N+   A++  G   A   ++ ++         
Sbjct: 270  EDLTPEDDMPVGRNVLELTDVKDSA---NYTCVAMSSLGVIEAVAQITVKS--------- 317

Query: 738  VPEVPSSLHVRP-LVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQ-TIKVDYKQRYYT 795
            +P+ P +  V     TSI ++W       +    Y I Y   S      IK D     Y+
Sbjct: 318  LPKAPGTPMVTENTATSITITWDSGNPDPVSY--YVIEYKSKSQDGPYQIKEDITTTRYS 375

Query: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMM 855
            I  L P+S Y I + A N++G+G P  ES VTR                     +  P  
Sbjct: 376  IGGLSPNSEYEIWVSAVNSIGQGPPS-ESVVTR-------------------TGEQAPAS 415

Query: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSY 915
             P  VQA +LS  T+ + W +   P         YYT+  +   P     K+    +L  
Sbjct: 416  APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTM--EPEHPVGNWQKHNVDDSLLT 473

Query: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIV 975
             V  L  +  Y   V+          S      T + VP  P   + + ++     +I +
Sbjct: 474  TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQP---MNLRAEARSETSITL 530

Query: 976  NWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQAR 1035
            +W PP + +      II Y        H   +        ++ +++L  +T Y F++ AR
Sbjct: 531  SWSPPRQES------IIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR 584

Query: 1036 NSKGMGPMSEAVQFRTPKADSS 1057
            + +G+G  +  V+ RT ++  S
Sbjct: 585  SPQGLGAFTPVVRQRTLQSKPS 606


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  266 bits (681), Expect = 8e-71
 Identities = 291/1078 (26%), Positives = 453/1078 (42%), Gaps = 155/1078 (14%)

Query: 51   TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP--DGS 108
            TP  F   PVD   V G      C A  +P PKI W K G     VS+ R +++   DGS
Sbjct: 22   TPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKG---KKVSNQRFEVIEFDDGS 78

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA------GLPRFTSQPEPSS 162
              +  +   +  + DE  Y+CVA+  ++G I   T   ++       G P     P+   
Sbjct: 79   GSVLRIQPLRTPR-DEAIYECVAS-NNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136

Query: 163  VYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDD---RVIKLPS---------GMLVISN 210
            V     A + C  + +  P + W ++  P+   +   R+ +L S         G L I  
Sbjct: 137  VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196

Query: 211  ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVI-GQDVVLP 269
            + E D G Y CV  +    +YS    L V    EV         P     ++ G  V + 
Sbjct: 197  SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256

Query: 270  CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
            CVA G P P +KWM   E L  E     + +    LE++DV +  +  Y C+A +    I
Sbjct: 257  CVAVGSPMPYVKWMLGAEDLTPEDD---MPIGRNVLELNDVRQ--SANYTCVAMSTLGVI 311

Query: 330  EAQAELTVQAQPEFLKQP-TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK 388
            EA A++TV+A P   K P T +    +   +     +G P P   ++         + +K
Sbjct: 312  EAIAQITVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 389  I---VKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPR 443
                V      V GL    +  ++ +A N++G       ++    E AP+      SAPR
Sbjct: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS------SAPR 422

Query: 444  DVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT-IQN 502
            DV A ++S+  I + W+ P  +P+G    Y V+YT +           +  + Q+T I N
Sbjct: 423  DVQARMLSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481

Query: 503  LMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP 562
            L+P   Y  +V+A    G G  S+ ++V TQ  V  PG   N +A   S TSI ++W  P
Sbjct: 482  LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV--PGQPLNFKAEPESETSILLSWTPP 539

Query: 563  VSGNGEIQNYKLYYMEKGTDKEQDVDVS-SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
             S    I NY+L Y +    +EQ + +    SY + GLK  + Y FR+ A +  G G ST
Sbjct: 540  RSDT--IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
             +++ RT+   PSA PQ++S    +S SI++ WQPP    QNG IT Y I+Y     + D
Sbjct: 598  AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDD 657

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
                +  +       L+E L++ TEY   V A T  G GP +  +   T E       VP
Sbjct: 658  KPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED------VP 711

Query: 740  E-VPSSLHVRPL-VTSIVVSWTPP--ENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYT 795
               P  + V  +  TS+ VSW  P    Q+  +RG                  Y+  Y  
Sbjct: 712  SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRG------------------YQVHYVR 753

Query: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRP----HTDTSEVDLFVINAPYTPVPDP 851
            +EN +P               +G P+ +  +         DT+E D+ +           
Sbjct: 754  MENGEP---------------KGQPMLKDVMLADAQWEFDDTTEHDMII----------- 787

Query: 852  TPMMPPVGVQASILSHDTI--------RITWADNSLPKHQKI----TDSRYYTVRWKTNI 899
            + + P      ++ ++ T         ++     ++P   ++    T      ++W    
Sbjct: 788  SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-- 845

Query: 900  PANTKYKNANATTLSYLVTGLKPNTLYEFSVM--------VTKGR----RSSTWSMTAHG 947
            P +T +       L +    ++P T  EFS          + KG     R S  +    G
Sbjct: 846  PVDT-FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904

Query: 948  TTF-------ELVPTSPPKDVTVVSKEGKPKTII-VNWQPP--SEANGKITGYIIYYSTD 997
                      E VPT  P+++     EG   T + ++WQPP  +E NG IT Y + Y  D
Sbjct: 905  EEMVKEISIPEEVPTGFPQNL---HSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-D 960

Query: 998  VNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKAD 1055
            +N  +   + + +V    T  +  L  DT Y  K++A  SKG GP S +VQFRT   D
Sbjct: 961  INIPLLP-MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1017



 Score =  199 bits (505), Expect = 2e-50
 Identities = 227/1026 (22%), Positives = 401/1026 (39%), Gaps = 120/1026 (11%)

Query: 66   RGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR--QLLPD---GSLFISNVVHSKHN 120
            R  +  + C+A   P P+I W KD   ++  +++ R  QL  +   G+     +   +  
Sbjct: 139  RTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSE 198

Query: 121  KPDEGYYQCVATVESLGTIISRTAKLIVAGL-------PRFTSQPEPSSVYAGNNAILNC 173
            + D+G Y+CVAT  S GT  S  A L V  L       PRF+  P    +  G +  + C
Sbjct: 199  ESDQGKYECVAT-NSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITC 257

Query: 174  EVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPPKYS 232
                  +P+V+W    + L  +D    +P G  V+          Y CV  S  G  +  
Sbjct: 258  VAVGSPMPYVKWMLGAEDLTPED---DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAI 314

Query: 233  DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-----KNEE 287
             ++ +K LP P            +P+V       +     SG P P   ++     KN E
Sbjct: 315  AQITVKALPKPP----------GTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE 364

Query: 288  ALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQ 346
             L  E       +A     ++ ++      +  +A N       ++  LT  ++      
Sbjct: 365  ELYKEIDG----VATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 347  PTNIYAH--ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ------VL 398
            P ++ A    S  I+ + +   +P   ++  +    + P+ +     +HN+       + 
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 399  GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
             LV       + +A   +G+    + + ++     T   +P  P +  A   S   I L+
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-----TQTGVPGQPLNFKAEPESETSILLS 535

Query: 459  WRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK 518
            W  P SD   +   Y + Y K+G   E    T  PG     +Q L P ++Y FR+ A++ 
Sbjct: 536  WTPPRSDTIAN---YELVY-KDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSP 590

Query: 519  HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYY 576
             G G S+A +   T  + +   P  ++   + S TSI V+W+ P     NG I  Y + Y
Sbjct: 591  QGLGASTAEISARTM-QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 577  MEKGTDKEQD-------VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
                 D E D       +   +  Y +  L+K+TEY   V A+   GPG  +  V +RT 
Sbjct: 650  T--AVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707

Query: 630  SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSG 689
             DVPS  P+ + +E  NS S+ + W+ P P  Q+GQI GY++ Y +        + ++  
Sbjct: 708  EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767

Query: 690  TQLS-------------QLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDET 736
              L+              +I GL   T Y+  V A T  G G  +      T  +     
Sbjct: 768  VMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA----- 822

Query: 737  RVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPH-AQTIKVDYKQRYYT 795
             VP  P  +     + + ++ W PP +    ++GY + +G        T++   K+ ++T
Sbjct: 823  -VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881

Query: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMM 855
              ++   + YV  L A N VG G  + +                        +P+  P  
Sbjct: 882  ATDIHKGASYVFRLSARNKVGFGEEMVKE---------------------ISIPEEVPTG 920

Query: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSY 915
             P  + +   +  +++++W    L +   I  ++Y  +    NIP     +       + 
Sbjct: 921  FPQNLHSEGTTSTSVQLSWQPPVLAERNGII-TKYTLLYRDINIPLLPMEQLIVPADTTM 979

Query: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIV 975
             +TGLKP+T Y+  V     +    +S +     F  +P           K     ++++
Sbjct: 980  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQ---FRTLPVDQVFAKNFHVKAVMKTSVLL 1036

Query: 976  NWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQAR 1035
            +W+ P   N  +   I+Y            ++E V G      I  L  +  Y F +  R
Sbjct: 1037 SWEIPENYNSAMPFKILYDDGK--------MVEEVDGRATQKLIVNLKPEKSYSFVLTNR 1088

Query: 1036 NSKGMG 1041
             +   G
Sbjct: 1089 GNSAGG 1094



 Score =  121 bits (303), Expect = 6e-27
 Identities = 170/749 (22%), Positives = 292/749 (38%), Gaps = 98/749 (13%)

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN--- 394
            +  P F + P +          F C+ TG P P + W K G  V  +  F++++  +   
Sbjct: 21   ETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV-SNQRFEVIEFDDGSG 79

Query: 395  --LQVLGL-VKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASL 449
              L++  L    DE  Y+C+A N+VG      +L +L  +  P     +   P+  V   
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 450  VSTRFI----------KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
              T  +          ++TW          N    +    + +  E +  T   G +Q+ 
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRI----KQLRSESIGGTPIRGALQIE 195

Query: 500  IQNLMPATVYIFRVMAQNKHGSGESS-APLRVETQPEVQLPGPAPNLRAYAASPT----- 553
                     Y    +A N  G+  S+ A L V    EV+   P      ++  PT     
Sbjct: 196  QSEESDQGKY--ECVATNSAGTRYSAPANLYVRELREVRRVPPR-----FSIPPTNHEIM 248

Query: 554  ---SITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVV 610
               S+ +T    V+    +   K     +    E D+ +  +   +N +++   Y+   V
Sbjct: 249  PGGSVNITC---VAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYT--CV 303

Query: 611  AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
            A +  G   +   + V+ L   P       S     + SI + W      + N +   Y 
Sbjct: 304  AMSTLGVIEAIAQITVKALPKPPGTPVVTES----TATSITLTWD-----SGNPEPVSYY 354

Query: 671  IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
            I   K     ++ + +         + GL   ++Y FRV A+   G GP ++ +  +T  
Sbjct: 355  IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT-- 412

Query: 731  SDLDETRVPEVPSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDY 789
                E      P  +  R L  T+I+V W  PE  N  ++GY + Y +         + +
Sbjct: 413  ---SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKH 469

Query: 790  K---QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
                 +  TI NL P   Y + + AF ++G+G PL               D+ VI    T
Sbjct: 470  NVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSS-------------DIQVITQ--T 513

Query: 847  PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYK 906
             VP       P+  +A   S  +I ++W     P+   I +   Y + +K       +  
Sbjct: 514  GVPGQ-----PLNFKAEPESETSILLSWTP---PRSDTIAN---YELVYKDGEHGEEQRI 562

Query: 907  NANATTLSYLVTGLKPNTLYEFSVMVT--KGRRSSTWSMTAHGTTFELVPTSPPKDVTVV 964
                 T SY + GLKPN+LY F +     +G  +ST  ++A   T +  P++PP+D++  
Sbjct: 563  TIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR--TMQSKPSAPPQDISCT 619

Query: 965  SKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQEL 1022
            S      +I+V+WQPP   + NG IT Y I Y+     +     I  +  +   + +++L
Sbjct: 620  SPSST--SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQL 677

Query: 1023 TLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
               T Y   + A    G GP S +V  RT
Sbjct: 678  EKWTEYRITVTAHTDVGPGPESLSVLIRT 706



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 69/266 (25%), Positives = 106/266 (39%), Gaps = 35/266 (13%)

Query: 794  YTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTP 853
            Y++  L P S Y   + A NN+G G P             SE  L       T   +  P
Sbjct: 378  YSVAGLSPYSDYEFRVVAVNNIGRGPP-------------SEPVL-------TQTSEQAP 417

Query: 854  MMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANA--T 911
               P  VQA +LS  TI + W +   P  Q      YYT+    ++    K+  A++  T
Sbjct: 418  SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 477

Query: 912  TLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPK 971
            T+  LV    P   Y   V+          S      T   VP  P   +   ++     
Sbjct: 478  TIGNLV----PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP---LNFKAEPESET 530

Query: 972  TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFK 1031
            +I+++W PP   +  I  Y + Y    + E     IEP    RL    Q L  ++ YYF+
Sbjct: 531  SILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRL----QGLKPNSLYYFR 584

Query: 1032 IQARNSKGMGPMSEAVQFRTPKADSS 1057
            + AR+ +G+G  +  +  RT ++  S
Sbjct: 585  LAARSPQGLGASTAEISARTMQSKPS 610


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  260 bits (665), Expect = 6e-69
 Identities = 280/1072 (26%), Positives = 435/1072 (40%), Gaps = 146/1072 (13%)

Query: 52   PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
            P  F+ EP D + V G      C A  +P P++ W K G  +N  S     +  D S   
Sbjct: 32   PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN--SQRFETIEFDESAGA 89

Query: 112  SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV-------AGLPRFTSQPEPSSVY 164
               +       DE  Y+CVA   S+G I    AKL V       +G P     P+   V 
Sbjct: 90   VLRIQPLRTPRDENVYECVAQ-NSVGEITVH-AKLTVLREDQLPSGFPNIDMGPQLKVVE 147

Query: 165  AGNNAILNCEVNADLVPFVRWEQNRQPL---LLDDRVIKLPS---------GMLVISNAT 212
                A + C  + +  P + W ++  P+     + R+ +L S         G L I ++ 
Sbjct: 148  RTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSE 207

Query: 213  EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVI--------GQ 264
            E D G Y CV  +    +YS    L V    EV       ++ +P   ++        G 
Sbjct: 208  ETDQGKYECVATNSAGVRYSSPANLYVRELREV-------RRVAPRFSILPMSHEIMPGG 260

Query: 265  DVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN 324
            +V + CVA G P P +KWM+  E L  E     + +    LE++DV   D+  Y C+A +
Sbjct: 261  NVNITCVAVGSPMPYVKWMQGAEDLTPEDD---MPVGRNVLELTDVK--DSANYTCVAMS 315

Query: 325  GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWV---KNGDMV 381
                IEA A++TV++ P+    P  +  + +  I    + +G P P   +V   K+    
Sbjct: 316  SLGVIEAVAQITVKSLPKAPGTPM-VTENTATSITITWD-SGNPDPVSYYVIEYKSKSQD 373

Query: 382  IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLP 439
             P    + +      + GL  + E      A N +G       ++    E APA      
Sbjct: 374  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA------ 427

Query: 440  SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEG---IARERVENTSHPGEM 496
            SAPR+V A ++S   + + W  P  +P+G    Y V+YT E    +   +  N      +
Sbjct: 428  SAPRNVQARMLSATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD--SL 484

Query: 497  QVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSIT 556
              T+ +L+    Y  RV+A    G G  S P++V+TQ  V  PG   NLRA A S TSIT
Sbjct: 485  LTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV--PGQPMNLRAEARSETSIT 542

Query: 557  VTWETPVSGNGEIQNYKLYYME--KGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
            ++W  P   +  I  Y+L + E   G +  +  D ++ SY +  LK  TEY+FR+ A + 
Sbjct: 543  LSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTT-SYVVEDLKPNTEYAFRLAARSP 599

Query: 615  HGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYR 674
             G G  TP V  RTL   PSA PQ++      S +I++ W+PP P T NG + GY +RYR
Sbjct: 600  QGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659

Query: 675  KASRKSDVTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESD 732
                +    + +  +  T    L+E L++ T+Y     A T  G GP +   S     +D
Sbjct: 660  PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES---SPVVVRTD 716

Query: 733  LDETRVPEVPSSLHVRPL-VTSIVVSWTPPE--NQNIVVRGYAIGY-------GIGSPHA 782
             D    P  P  +    L  T+I V W  P    Q+  +RGY + Y         G P  
Sbjct: 717  EDVPSAP--PRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 774

Query: 783  QTIKV--------DYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTS 834
            + + +        D  +    I NL P + Y IT+ A+   G+G       V        
Sbjct: 775  KDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLG 834

Query: 835  EVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVR 894
               L V   P                + S+L+       W   +     ++   R    R
Sbjct: 835  RPTLSVQQTP----------------EGSLLAR------WEPPAGTAEDQVLGYRLQFGR 872

Query: 895  WKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVP 954
              +   A  ++  +      Y  +G+     Y F +        S   +         +P
Sbjct: 873  EDSTPLATLEFPPSED---RYTASGVHKGATYVFRLAA-----RSRGGLGEEAAEVLSIP 924

Query: 955  TSPPK---DVTVVSKEGKPKTIIVNWQP--PSEANGKITGYIIYY----------STDVN 999
               P+    +   +      T+++ W P  P+E NG I  Y +             T++ 
Sbjct: 925  EDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELP 984

Query: 1000 AEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
            A       EP   N LT  +Q L  DT Y  +++A   +G GP S  V++RT
Sbjct: 985  A-----AAEPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1029



 Score =  167 bits (422), Expect = 9e-41
 Identities = 213/896 (23%), Positives = 349/896 (38%), Gaps = 134/896 (14%)

Query: 251  FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVL--LAGGSLEIS 308
            F+K+P   + V G      C A+G P P + W K  + ++++  E +     AG  L I 
Sbjct: 35   FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQ 94

Query: 309  DV-TEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFE------ 361
             + T  D   Y C+A N    I   A+LTV  + +      NI     + +V        
Sbjct: 95   PLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATM 154

Query: 362  -CEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN------------LQVLGLVKSDEGFY 408
             C  +G P P + W K+   V PS     +K+              LQ+    ++D+G Y
Sbjct: 155  LCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQGKY 214

Query: 409  QCIAENDVG-NAQAGAQLIILEHA------------PATTGPLPSAPRDVVASLVSTRFI 455
            +C+A N  G    + A L + E              P +   +P    ++    V +   
Sbjct: 215  ECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMP 274

Query: 456  KLTWRTPASD--PHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
             + W   A D  P  D            + R  +E T        T              
Sbjct: 275  YVKWMQGAEDLTPEDDM----------PVGRNVLELTDVKDSANYTC------------- 311

Query: 514  MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGE-IQNY 572
            +A +  G  E+ A + V++ P+   PG  P +    A  TSIT+TW+   SGN + +  Y
Sbjct: 312  VAMSSLGVIEAVAQITVKSLPKA--PG-TPMVTENTA--TSITITWD---SGNPDPVSYY 363

Query: 573  KLYYMEKGTDKEQDV--DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 630
             + Y  K  D    +  D+++  Y+I GL   +EY   V A N  G G  +  V  RT  
Sbjct: 364  VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 423

Query: 631  DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKAS-------RKSDVT 683
              P++AP+N+   + ++ ++++ W+ P     NG I GY++ Y           +K +V 
Sbjct: 424  QAPASAPRNVQARMLSATTMIVQWEEPVEP--NGLIRGYRVYYTMEPEHPVGNWQKHNVD 481

Query: 684  ETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPS 743
            ++L+  T +  L+E       Y  RV A T  G GP +D +  +T +       VP  P 
Sbjct: 482  DSLL--TTVGSLLED----ETYTVRVLAFTSVGDGPLSDPIQVKTQQG------VPGQPM 529

Query: 744  SLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPS 802
            +L       TSI +SW+PP  ++I+   Y + +  G    +  +       Y +E+L P+
Sbjct: 530  NLRAEARSETSITLSWSPPRQESIIK--YELLFREGDHGREVGRTFDPTTSYVVEDLKPN 587

Query: 803  SHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQA 862
            + Y   L A +  G G     + V R  T  S+                 P  PP  V+ 
Sbjct: 588  TEYAFRLAARSPQGLGA---FTPVVRQRTLQSK-----------------PSAPPQDVKC 627

Query: 863  SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANA---TTLSYLVTG 919
              +    I ++W       H        Y+VR++     + + K  N    TT   L+  
Sbjct: 628  VSVRSTAILVSWRPPPPETHNGALVG--YSVRYRPLGSEDPEPKEVNGIPPTTTQILLEA 685

Query: 920  LKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQP 979
            L+  T Y  + +          S      T E VP++PP+ V   +       ++     
Sbjct: 686  LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPA 745

Query: 980  PSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKG 1039
            P   +G+I GY ++Y     AE       P + + +    Q  T DT  Y ++   N + 
Sbjct: 746  PGRQHGQIRGYQVHYVRMEGAEARG---PPRIKDVMLADAQWETDDTAEY-EMVITNLQP 801

Query: 1040 MGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGS 1095
                S  V   T K D +   P    +    KG+ L       +P +S   +P GS
Sbjct: 802  ETAYSITVAAYTMKGDGARSKPKVVVT----KGAVLG------RPTLSVQQTPEGS 847



 Score =  120 bits (301), Expect = 1e-26
 Identities = 116/442 (26%), Positives = 187/442 (42%), Gaps = 49/442 (11%)

Query: 411  IAENDVGNAQAGAQLIILEHAPATTGPLPSAP-RDVVASLVSTRFIKLTWRTPASD-PHG 468
            +A  +VG     + +++      T   +PSAP R V A  ++   I++ WR+PA    HG
Sbjct: 697  VAHTEVGPGPESSPVVV-----RTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 751

Query: 469  DNLTYSVFYTK----EGIARERVEN---------TSHPGEMQVTIQNLMPATVYIFRVMA 515
                Y V Y +    E     R+++         T    E ++ I NL P T Y   V A
Sbjct: 752  QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAA 811

Query: 516  QNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV-SGNGEIQNYKL 574
                G G  S P  V T+  V      P L        S+   WE P  +   ++  Y+L
Sbjct: 812  YTMKGDGARSKPKVVVTKGAVL---GRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868

Query: 575  YYMEKGTDKEQDVDV--SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDV 632
             +  + +     ++   S   YT +G+ K   Y FR+ A ++ G G    +V +    D 
Sbjct: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEV-LSIPEDT 927

Query: 633  PSAAPQNLSLEVRNSK-SIMIHWQPPAPATQNGQITGYKIRYRKA-----SRKSDVTETL 686
            P   PQ L      S  ++++ W PP PA +NG I  Y +  R+A     +R++++    
Sbjct: 928  PRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAA 987

Query: 687  VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
              G + +  ++GL   T Y+ +V A T  G GP +  +   TF  D         P +  
Sbjct: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRD------QVSPKNFK 1041

Query: 747  VRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHY 805
            V+ ++ TS+++SW  P+N N     Y I Y     +  T+ VD +     I +L P + Y
Sbjct: 1042 VKMIMKTSVLLSWEFPDNYNSPT-PYKIQY-----NGLTLDVDGRTTKKLITHLKPHTFY 1095

Query: 806  VITLKAFNNVGEGIPLYESAVT 827
               L    N G  +   +  VT
Sbjct: 1096 NFVL---TNRGSSLGGLQQTVT 1114


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
           3 precursor [Homo sapiens]
          Length = 1903

 Score =  254 bits (650), Expect = 3e-67
 Identities = 235/809 (29%), Positives = 357/809 (44%), Gaps = 71/809 (8%)

Query: 51  TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP--DGS 108
           TP  F   PVD   V G      C A  +P PKI W K G     VS+ R +++   DGS
Sbjct: 22  TPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKG---KKVSNQRFEVIEFDDGS 78

Query: 109 LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA------GLPRFTSQPEPSS 162
             +  +   +  + DE  Y+CVA+  ++G I   T   ++       G P     P+   
Sbjct: 79  GSVLRIQPLRTPR-DEAIYECVAS-NNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136

Query: 163 VYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDD---RVIKLPS---------GMLVISN 210
           V     A + C  + +  P + W ++  P+   +   R+ +L S         G L I  
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196

Query: 211 ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVI-GQDVVLP 269
           + E D G Y CV  +    +YS    L V    EV         P     ++ G  V + 
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256

Query: 270 CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
           CVA G P P +KWM   E L  E     + +    LE++DV +  +  Y C+A +    I
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLTPEDD---MPIGRNVLELNDVRQ--SANYTCVAMSTLGVI 311

Query: 330 EAQAELTVQAQPEFLKQP-TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK 388
           EA A++TV+A P   K P T +    +   +     +G P P   ++         + +K
Sbjct: 312 EAIAQITVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 389 I---VKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPR 443
               V      V GL    +  ++ +A N++G       ++    E AP+      SAPR
Sbjct: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS------SAPR 422

Query: 444 DVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT-IQN 502
           DV A ++S+  I + W+ P  +P+G    Y V+YT +           +  + Q+T I N
Sbjct: 423 DVQARMLSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481

Query: 503 LMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP 562
           L+P   Y  +V+A    G G  S+ ++V TQ  V  PG   N +A   S TSI ++W  P
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV--PGQPLNFKAEPESETSILLSWTPP 539

Query: 563 VSGNGEIQNYKLYYMEKGTDKEQDVDVS-SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S    I NY+L Y +    +EQ + +    SY + GLK  + Y FR+ A +  G G ST
Sbjct: 540 RSDT--IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 622 PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
            +++ RT+   PSA PQ++S    +S SI++ WQPP    QNG IT Y I+Y     + D
Sbjct: 598 AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDD 657

Query: 682 VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
               +  +       L+E L++ TEY   V A T  G GP +  +   T E       VP
Sbjct: 658 KPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED------VP 711

Query: 740 E-VPSSLHVRPL-VTSIVVSWTP--PENQNIVVRGYAIGY---GIGSPHAQTIKVDY--- 789
              P  + V  +  TS+ VSW    P  Q+  +RGY + Y     G P  Q +  D    
Sbjct: 712 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 771

Query: 790 KQRYYTIENLDPSSHYVITLKAFNNVGEG 818
             +   I  L P + Y +T+ A+   G+G
Sbjct: 772 DAQDMIISGLQPETSYSLTVTAYTTKGDG 800



 Score =  243 bits (619), Expect = 1e-63
 Identities = 247/940 (26%), Positives = 381/940 (40%), Gaps = 118/940 (12%)

Query: 152  PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDD-RVIKLPSG----ML 206
            PRFT  P   +  +G  A   C+   D  P + W +  + +      VI+   G    + 
Sbjct: 24   PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLR 83

Query: 207  VISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQD- 265
            +    T  D  +Y CV  S    + S    L VL + ++      +    P ++V+ +  
Sbjct: 84   IQPLRTPRDEAIYECVA-SNNVGEISVSTRLTVLREDQIPRGFPTIDM-GPQLKVVERTR 141

Query: 266  -VVLPCVASGLPTPTIKWMKNEEALDTESSE------RLVLLAG----GSLEISDVTEDD 314
               + C ASG P P I W K+   +DT ++       R   + G    G+L+I    E D
Sbjct: 142  TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201

Query: 315  AGTYFCIADNGNET-IEAQAELTVQ-------AQPEFLKQPTNIYAHESMDIVFECEVTG 366
             G Y C+A N   T   A A L V+         P F   PTN        +   C   G
Sbjct: 202  QGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 261

Query: 367  KPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLI 426
             P P VKW+   + + P D   I +  N+  L  V+     Y C+A + +G  +A AQ+ 
Sbjct: 262  SPMPYVKWMLGAEDLTPEDDMPIGR--NVLELNDVRQSAN-YTCVAMSTLGVIEAIAQI- 317

Query: 427  ILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARER 486
                   T   LP  P   V +  +   I LTW +   +P    ++Y +   K   + E 
Sbjct: 318  -------TVKALPKPPGTPVVTESTATSITLTWDSGNPEP----VSYYIIQHKPKNSEEL 366

Query: 487  VENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP-NL 545
             +        + ++  L P + Y FRV+A N  G G  S P  V TQ   Q P  AP ++
Sbjct: 367  YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDV 424

Query: 546  RAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVD-------VSSHSYTING 598
            +A   S T+I V W+ P   NG+IQ Y++YY     D  Q V+         S   TI  
Sbjct: 425  QARMLSSTTILVQWKEPEEPNGQIQGYRVYYT---MDPTQHVNNWMKHNVADSQITTIGN 481

Query: 599  LKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPA 658
            L     YS +V+A+   G G  + D+ V T + VP   P N   E  +  SI++ W PP 
Sbjct: 482  LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTPPR 540

Query: 659  PATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTG 718
              T    I  Y++ Y+      +   T+  GT  S  ++GL   + Y FR+AA +  G G
Sbjct: 541  SDT----IANYELVYKDGEHGEEQRITIEPGT--SYRLQGLKPNSLYYFRLAARSPQGLG 594

Query: 719  PATDWLSAETFESDLDETRVPEVPSS--LHVRPLVTSIVVSWTPP--ENQNIVVRGYAIG 774
             +T  +SA T +S       P  P        P  TSI+VSW PP  E QN ++  Y+I 
Sbjct: 595  ASTAEISARTMQSK------PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK 648

Query: 775  YGI-----GSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRP 829
            Y         PH + + +      Y +E L+  + Y IT+ A  +VG G P   S + R 
Sbjct: 649  YTAVDGEDDKPH-EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRT 706

Query: 830  HTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPK-HQKITDS 888
            + D                    P  PP  V+   ++  +++++W      K H +I   
Sbjct: 707  NEDV-------------------PSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGY 747

Query: 889  RYYTVRWKTNIPANTKYKN--ANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAH 946
            + + VR +   P           A     +++GL+P T Y  +V     +     S    
Sbjct: 748  QVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 807

Query: 947  GTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWV 1006
             +T   VP  P     +V    +  T ++ W PP +  G + GY + +            
Sbjct: 808  VSTTGAVPGKP----RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK--------D 855

Query: 1007 IEPVVGNRLTHQIQELTL-----DTPYYFKIQARNSKGMG 1041
            +EP+     + +    T         Y F++ ARN  G G
Sbjct: 856  MEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 895



 Score =  202 bits (514), Expect = 2e-51
 Identities = 227/1017 (22%), Positives = 401/1017 (39%), Gaps = 111/1017 (10%)

Query: 66   RGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR--QLLPD---GSLFISNVVHSKHN 120
            R  +  + C+A   P P+I W KD   ++  +++ R  QL  +   G+     +   +  
Sbjct: 139  RTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSE 198

Query: 121  KPDEGYYQCVATVESLGTIISRTAKLIVAGL-------PRFTSQPEPSSVYAGNNAILNC 173
            + D+G Y+CVAT  S GT  S  A L V  L       PRF+  P    +  G +  + C
Sbjct: 199  ESDQGKYECVAT-NSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITC 257

Query: 174  EVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPPKYS 232
                  +P+V+W    + L  +D    +P G  V+          Y CV  S  G  +  
Sbjct: 258  VAVGSPMPYVKWMLGAEDLTPED---DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAI 314

Query: 233  DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-----KNEE 287
             ++ +K LP P            +P+V       +     SG P P   ++     KN E
Sbjct: 315  AQITVKALPKPP----------GTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE 364

Query: 288  ALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQ 346
             L  E       +A     ++ ++      +  +A N       ++  LT  ++      
Sbjct: 365  ELYKEIDG----VATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 347  PTNIYAH--ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ------VL 398
            P ++ A    S  I+ + +   +P   ++  +    + P+ +     +HN+       + 
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 399  GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
             LV       + +A   +G+    + + ++     T   +P  P +  A   S   I L+
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-----TQTGVPGQPLNFKAEPESETSILLS 535

Query: 459  WRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK 518
            W  P SD   +   Y + Y K+G   E    T  PG     +Q L P ++Y FR+ A++ 
Sbjct: 536  WTPPRSDTIAN---YELVY-KDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSP 590

Query: 519  HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYY 576
             G G S+A +   T  + +   P  ++   + S TSI V+W+ P     NG I  Y + Y
Sbjct: 591  QGLGASTAEISARTM-QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649

Query: 577  MEKGTDKEQD-------VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
                 D E D       +   +  Y +  L+K+TEY   V A+   GPG  +  V +RT 
Sbjct: 650  T--AVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707

Query: 630  SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSG 689
             DVPS  P+ + +E  NS S+ + W+ P P  Q+GQI GY++ Y +        + ++  
Sbjct: 708  EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767

Query: 690  TQLSQ----LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSL 745
              L+     +I GL   T Y+  V A T  G G  +      T  +      VP  P  +
Sbjct: 768  VMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA------VPGKPRLV 821

Query: 746  HVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHA-QTIKVDYKQRYYTIENLDPSSH 804
                 + + ++ W PP +    ++GY + +G        T++   K+ ++T  ++   + 
Sbjct: 822  INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGAS 881

Query: 805  YVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASI 864
            YV  L A N VG G  + +                        +P+  P   P  + +  
Sbjct: 882  YVFRLSARNKVGFGEEMVKEI---------------------SIPEEVPTGFPQNLHSEG 920

Query: 865  LSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNT 924
             +  +++++W    L +   I  ++Y  +    NIP     +       +  +TGLKP+T
Sbjct: 921  TTSTSVQLSWQPPVLAERNGII-TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDT 979

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEAN 984
             Y+  V     +    +S +     F  +P           K     +++++W+ P   N
Sbjct: 980  TYDVKVRAHTSKGPGPYSPSVQ---FRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYN 1036

Query: 985  GKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMG 1041
              +   I+Y            ++E V G      I  L  +  Y F +  R +   G
Sbjct: 1037 SAMPFKILYDDGK--------MVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGG 1085



 Score =  140 bits (352), Expect = 1e-32
 Identities = 130/459 (28%), Positives = 189/459 (41%), Gaps = 38/459 (8%)

Query: 382  IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSA 441
            IPSD  K + E       L K  E      A  DVG       ++I  +    +GP    
Sbjct: 665  IPSDTTKYLLEQ------LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP---- 714

Query: 442  PRDVVASLVSTRFIKLTWRTPASDP-HGDNLTYSVFYTK----EGIARERVENTSHPGEM 496
            PR V    V++  +K++WR+P  +  HG    Y V Y +    E   +  +++       
Sbjct: 715  PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 774

Query: 497  QVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSIT 556
             + I  L P T Y   V A    G G  S P  V T   V  PG  P L        +  
Sbjct: 775  DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAV--PGK-PRLVINHTQMNTAL 831

Query: 557  VTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS--YTINGLKKYTEYSFRVVAYNK 614
            + W  PV   G +Q Y+L +  K  +    ++ S     +T   + K   Y FR+ A NK
Sbjct: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 891

Query: 615  HGPGVSTPDVAVRTLS---DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKI 671
             G G    +  V+ +S   +VP+  PQNL  E   S S+ + WQPP  A +NG IT Y +
Sbjct: 892  VGFG----EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTL 947

Query: 672  RYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFES 731
             YR  +      E L+     +  + GL   T Y+ +V A T  G GP +  +   T   
Sbjct: 948  LYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1007

Query: 732  DLDETRVPEVPSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYK 790
            D           + HV+ ++ TS+++SW  PEN N  +  + I Y  G       +VD +
Sbjct: 1008 D------QVFAKNFHVKAVMKTSVLLSWEIPENYNSAM-PFKILYDDGK---MVEEVDGR 1057

Query: 791  QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRP 829
                 I NL P   Y   L    N   G+    +A T P
Sbjct: 1058 ATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1096



 Score =  121 bits (303), Expect = 6e-27
 Identities = 170/749 (22%), Positives = 292/749 (38%), Gaps = 98/749 (13%)

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN--- 394
            +  P F + P +          F C+ TG P P + W K G  V  +  F++++  +   
Sbjct: 21   ETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV-SNQRFEVIEFDDGSG 79

Query: 395  --LQVLGL-VKSDEGFYQCIAENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASL 449
              L++  L    DE  Y+C+A N+VG      +L +L  +  P     +   P+  V   
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 450  VSTRFI----------KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
              T  +          ++TW          N    +    + +  E +  T   G +Q+ 
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRI----KQLRSESIGGTPIRGALQIE 195

Query: 500  IQNLMPATVYIFRVMAQNKHGSGESS-APLRVETQPEVQLPGPAPNLRAYAASPT----- 553
                     Y    +A N  G+  S+ A L V    EV+   P      ++  PT     
Sbjct: 196  QSEESDQGKY--ECVATNSAGTRYSAPANLYVRELREVRRVPPR-----FSIPPTNHEIM 248

Query: 554  ---SITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVV 610
               S+ +T    V+    +   K     +    E D+ +  +   +N +++   Y+   V
Sbjct: 249  PGGSVNITC---VAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYT--CV 303

Query: 611  AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
            A +  G   +   + V+ L   P       S     + SI + W      + N +   Y 
Sbjct: 304  AMSTLGVIEAIAQITVKALPKPPGTPVVTES----TATSITLTWD-----SGNPEPVSYY 354

Query: 671  IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
            I   K     ++ + +         + GL   ++Y FRV A+   G GP ++ +  +T  
Sbjct: 355  IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT-- 412

Query: 731  SDLDETRVPEVPSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDY 789
                E      P  +  R L  T+I+V W  PE  N  ++GY + Y +         + +
Sbjct: 413  ---SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKH 469

Query: 790  K---QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
                 +  TI NL P   Y + + AF ++G+G PL               D+ VI    T
Sbjct: 470  NVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSS-------------DIQVITQ--T 513

Query: 847  PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYK 906
             VP       P+  +A   S  +I ++W     P+   I +   Y + +K       +  
Sbjct: 514  GVPGQ-----PLNFKAEPESETSILLSWTP---PRSDTIAN---YELVYKDGEHGEEQRI 562

Query: 907  NANATTLSYLVTGLKPNTLYEFSVMV--TKGRRSSTWSMTAHGTTFELVPTSPPKDVTVV 964
                 T SY + GLKPN+LY F +     +G  +ST  ++A   T +  P++PP+D++  
Sbjct: 563  TIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR--TMQSKPSAPPQDISCT 619

Query: 965  SKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQEL 1022
            S      +I+V+WQPP   + NG IT Y I Y+     +     I  +  +   + +++L
Sbjct: 620  SPSS--TSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQL 677

Query: 1023 TLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
               T Y   + A    G GP S +V  RT
Sbjct: 678  EKWTEYRITVTAHTDVGPGPESLSVLIRT 706



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 69/266 (25%), Positives = 106/266 (39%), Gaps = 35/266 (13%)

Query: 794  YTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTP 853
            Y++  L P S Y   + A NN+G G P             SE  L       T   +  P
Sbjct: 378  YSVAGLSPYSDYEFRVVAVNNIGRGPP-------------SEPVL-------TQTSEQAP 417

Query: 854  MMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANA--T 911
               P  VQA +LS  TI + W +   P  Q      YYT+    ++    K+  A++  T
Sbjct: 418  SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 477

Query: 912  TLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPK 971
            T+  LV    P   Y   V+          S      T   VP  P   +   ++     
Sbjct: 478  TIGNLV----PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP---LNFKAEPESET 530

Query: 972  TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFK 1031
            +I+++W PP   +  I  Y + Y    + E     IEP    RL    Q L  ++ YYF+
Sbjct: 531  SILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRL----QGLKPNSLYYFR 584

Query: 1032 IQARNSKGMGPMSEAVQFRTPKADSS 1057
            + AR+ +G+G  +  +  RT ++  S
Sbjct: 585  LAARSPQGLGASTAEISARTMQSKPS 610



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 41/108 (37%), Positives = 58/108 (53%), Gaps = 8/108 (7%)

Query: 951  ELVPTSPPKDVTVVSKEGKPKTII-VNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVI 1007
            E VPT  P+++     EG   T + ++WQPP  +E NG IT Y + Y  D+N  +   + 
Sbjct: 906  EEVPTGFPQNL---HSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINIPLLP-ME 960

Query: 1008 EPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKAD 1055
            + +V    T  +  L  DT Y  K++A  SKG GP S +VQFRT   D
Sbjct: 961  QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1008


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  248 bits (634), Expect = 2e-65
 Identities = 282/1043 (27%), Positives = 429/1043 (41%), Gaps = 125/1043 (11%)

Query: 55   FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP--DGSLFIS 112
            F+  P D   + G      C A  EP P+I W K G     VS  R +++   DG+  + 
Sbjct: 35   FIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKG---KKVSSQRFEVIEFDDGAGSVL 91

Query: 113  NVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA-------GLPRFTSQPEPSSVYA 165
             +   +  + DE  Y+C AT  SLG I + +AKL V        G P     P+   V  
Sbjct: 92   RIQPLRVQR-DEAIYECTAT-NSLGEI-NTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEK 148

Query: 166  GNNAILNCEVNADLVPFVRWEQNRQPL---LLDDRVIKLPSGMLVISNATEGDGGLYRCV 222
               A + C    +  P + W ++  P+     + R+ +L SG L I ++ E D G Y CV
Sbjct: 149  ARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECV 208

Query: 223  VESGGPPKYSDEVEL-----KVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPT 277
              +    +YS    L     +V P         F   PS    + G  V L CVA G P 
Sbjct: 209  ATNSAGTRYSAPANLYVRVRRVAPR--------FSIPPSSQEVMPGGSVNLTCVAVGAPM 260

Query: 278  PTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTV 337
            P +KWM   E L  E     + +    LE+S+V    +  Y C+A +    IEA A++TV
Sbjct: 261  PYVKWMMGAEELTKEDE---MPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTV 315

Query: 338  QAQPEFLKQPTNIYAHE----SMDIVFECEVTGKPTPTVKW---VKNGDMVIPSDYFKIV 390
            +A P   K P ++   E    S+ + ++   +G   P   +    +      P      V
Sbjct: 316  KALP---KPPIDLVVTETTATSVTLTWD---SGNSEPVTYYGIQYRAAGTEGPFQEVDGV 369

Query: 391  KEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL--PSAPRDVVAS 448
                  + GL    E  ++ +A N +G           E   A TG     S PR V A 
Sbjct: 370  ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPS------EAVRARTGEQAPSSPPRRVQAR 423

Query: 449  LVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSH----PGEMQVTIQNLM 504
            ++S   + + W  P  +P+G    Y V+YT +     R  N  H       +  T+ +L+
Sbjct: 424  MLSASTMLVQWE-PPEEPNGLVRGYRVYYTPDS---RRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 505  PATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVS 564
            P   Y  RV+A    G G  S  ++V+TQ  V  P    + +A   S T I ++W  P  
Sbjct: 480  PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV--PAQPADFQAEVESDTRIQLSWLLP-- 535

Query: 565  GNGEIQNYKLYYMEKGTDKEQDVDVS---SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
                I  Y+L Y     D++Q   V+   + SYT+  LK  T Y F++ A +  G GV T
Sbjct: 536  PQERIIMYELVYW-AAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
            P +  RT    PSA PQ +      S ++ + W PP   ++NG IT Y + Y     +  
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDR 654

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
                +  +S    S  + GL++ TEY   V A T  G GP +  +   T     DE    
Sbjct: 655  GRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT-----DEDVPS 709

Query: 740  EVPSSLHVRPL-VTSIVVSW--TPPENQNIVVRGYAIGY---GIGSPHAQTIKVDY---K 790
              P  + V PL  T++ V W    P  Q+  +RGY + Y     G P    I  D    +
Sbjct: 710  GPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769

Query: 791  QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPD 850
             +  TI  L P + Y +T+ A+   G+G      A ++P   T+             VP 
Sbjct: 770  AQETTISGLTPETTYSVTVAAYTTKGDG------ARSKPKIVTTT----------GAVPG 813

Query: 851  PTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANA 910
               MM       S  + +T  + W     P  +   +   Y +++     A     +   
Sbjct: 814  RPTMM------ISTTAMNTALLQWH----PPKELPGELLGYRLQYCRADEARPNTIDFGK 863

Query: 911  TTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKP 970
                + VTGL   T Y F  +  K R            T E +P+  P+++ V       
Sbjct: 864  DDQHFTVTGLHKGTTYIFR-LAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL--TT 920

Query: 971  KTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPY 1028
             T  + W PP  +E NG+I  Y + +  D+N++    +       R T  +  L  DT Y
Sbjct: 921  STTELAWDPPVLAERNGRIISYTVVF-RDINSQ--QELQNITTDTRFT--LTGLKPDTTY 975

Query: 1029 YFKIQARNSKGMGPMSEAVQFRT 1051
              K++A  SKG GP+S ++Q RT
Sbjct: 976  DIKVRAWTSKGSGPLSPSIQSRT 998



 Score =  206 bits (524), Expect = 1e-52
 Identities = 233/964 (24%), Positives = 387/964 (40%), Gaps = 118/964 (12%)

Query: 138  TIISRTAKLIVAGL---------PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRW-EQ 187
            T++     L++ GL         P F   PE  +  +G  A   C+   +  P + W ++
Sbjct: 10   TMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKK 69

Query: 188  NRQPLLLDDRVIKLPSG----MLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDP 243
             ++       VI+   G    + +     + D  +Y C   +    + +   +L VL + 
Sbjct: 70   GKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTA-TNSLGEINTSAKLSVLEEE 128

Query: 244  EVISDLVFLKQPSPLVRVI--GQDVVLPCVASGLPTPTIKWMKNEEALDTESSE-RLVLL 300
            ++      +    P ++V+   +   + C A G P P I W K+   +D  +S  R+  L
Sbjct: 129  QLPPGFPSIDM-GPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQL 187

Query: 301  AGGSLEISDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQ---PEFLKQPTNIYAHESM 356
              G+L+I    E D G Y C+A N   T   A A L V+ +   P F   P++       
Sbjct: 188  RSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGG 247

Query: 357  DIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDV 416
             +   C   G P P VKW+   + +   D    V  + L++  +V+S    Y C+A + +
Sbjct: 248  SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMP-VGRNVLELSNVVRSAN--YTCVAISSL 304

Query: 417  GNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVF 476
            G  +A AQ+        T   LP  P D+V +  +   + LTW +  S+P    +TY   
Sbjct: 305  GMIEATAQV--------TVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGI 352

Query: 477  YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
              +        +        + +I  L P + Y FRV+A N  G G  S  +R  T  + 
Sbjct: 353  QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412

Query: 537  QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSY-- 594
                P   ++A   S +++ V WE P   NG ++ Y++YY    T   +    + H +  
Sbjct: 413  P-SSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYY----TPDSRRPPNAWHKHNT 467

Query: 595  ------TINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSK 648
                  T+  L     YS RV+A+   G G  +P + V+T   VP A P +   EV +  
Sbjct: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQAEVESDT 526

Query: 649  SIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFR 708
             I + W  P       +I  Y++ Y  A+   D    +      S  +E L   T Y F+
Sbjct: 527  RIQLSWLLP----PQERIIMYELVY-WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQ 581

Query: 709  VAALTINGTGPATDWLSAETFESDLDETRVPEVPSS--LHVRPLVTSIVVSWTPP--ENQ 764
            +AA +  G G  T  + A T +S       P  P    + V    T++ VSW PP  +++
Sbjct: 582  LAARSDMGVGVFTPTIEARTAQS------TPSAPPQKVMCVSMGSTTVRVSWVPPPADSR 635

Query: 765  NIVVRGYAIGYGI--GSPHAQTI--KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 820
            N V+  Y++ Y    G    + +   +  +   + +  L+  + Y + ++A  +VG G  
Sbjct: 636  NGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG-- 693

Query: 821  LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 880
              ES+     TD                 +  P  PP  V+   L+   + + W    LP
Sbjct: 694  -PESSPVLVRTD-----------------EDVPSGPPRKVEVEPLNSTAVHVYW---KLP 732

Query: 881  ----KHQKITDSRYYTVRWKTNIP------ANTKYKNANATTLSYLVTGLKPNTLYEFSV 930
                +H +I   +   VR +   P       +     A  TT+S    GL P T Y  +V
Sbjct: 733  VPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTIS----GLTPETTYSVTV 788

Query: 931  MVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGY 990
                 +     S     TT   VP  P    T++       T ++ W PP E  G++ GY
Sbjct: 789  AAYTTKGDGARSKPKIVTTTGAVPGRP----TMMISTTAMNTALLQWHPPKELPGELLGY 844

Query: 991  IIYYSTDVNAEIHDWVIEPVVGNRLTH-QIQELTLDTPYYFKIQARNSKGMGPMSEAVQF 1049
             + Y     A  +   I+   G    H  +  L   T Y F++ A+N  G+G   E  + 
Sbjct: 845  RLQYCRADEARPN--TID--FGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEK-EI 899

Query: 1050 RTPK 1053
            RTP+
Sbjct: 900  RTPE 903



 Score =  155 bits (391), Expect = 4e-37
 Identities = 149/627 (23%), Positives = 254/627 (40%), Gaps = 64/627 (10%)

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
            +P+ P D  A + S   I+L+W  P   P    + Y + Y       ++ + T  P    
Sbjct: 511  VPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAAEDEDQQHKVTFDPTS-S 566

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
             T+++L P T+Y F++ A++  G G  +  +   T        P   +   +   T++ V
Sbjct: 567  YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTP-SAPPQKVMCVSMGSTTVRV 625

Query: 558  TWETPV--SGNGEIQNYKLYYM-----EKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVV 610
            +W  P   S NG I  Y + Y      ++G      +     S+ + GL+K+TEY   V 
Sbjct: 626  SWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVR 685

Query: 611  AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
            A+   GPG  +  V VRT  DVPS  P+ + +E  NS ++ ++W+ P P+ Q+GQI GY+
Sbjct: 686  AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745

Query: 671  IRYRKASRKSDVTETLVSGTQLSQ----LIEGLDRGTEYNFRVAALTINGTGPATDWLSA 726
            + Y +          ++    L++     I GL   T Y+  VAA T  G G  +     
Sbjct: 746  VTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIV 805

Query: 727  ETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTI 785
             T  +      VP  P+ +     + + ++ W PP+     + GY + Y         TI
Sbjct: 806  TTTGA------VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI 859

Query: 786  KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPY 845
                  +++T+  L   + Y+  L A N  G G    +   T                  
Sbjct: 860  DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT------------------ 901

Query: 846  TPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKY 905
               P+  P   P  +  + L+  T  + W    L +      S  YTV ++     N++ 
Sbjct: 902  ---PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS--YTVVFR---DINSQQ 953

Query: 906  KNANATT-LSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVV 964
            +  N TT   + +TGLKP+T Y+  V     + S   S +    T   V     K+  V 
Sbjct: 954  ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMP-VEQVFAKNFRVA 1012

Query: 965  SKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTL 1024
            +      +++++W+ P      +   I+Y    V  +          G+ +   I +L  
Sbjct: 1013 A--AMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVD----------GHSMRKLIADLQP 1060

Query: 1025 DTPYYFKIQARNSKGMGPMSEAVQFRT 1051
            +T Y F +  R S   G +   V  RT
Sbjct: 1061 NTEYSFVLMNRGSSA-GGLQHLVSIRT 1086



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 78/324 (24%), Positives = 126/324 (38%), Gaps = 38/324 (11%)

Query: 738  VPEVPSSLHV-RPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVD-YKQRYYT 795
            +P+ P  L V     TS+ ++W    ++ +    Y I Y          +VD      Y+
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTY--YGIQYRAAGTEGPFQEVDGVATTRYS 375

Query: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMM 855
            I  L P S Y   + A N++G G P   S   R  T                  +  P  
Sbjct: 376  IGGLSPFSEYAFRVLAVNSIGRGPP---SEAVRARTG-----------------EQAPSS 415

Query: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSY 915
            PP  VQA +LS  T+ + W     P         YYT    +  P N  +K+     L  
Sbjct: 416  PPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP--DSRRPPNAWHKHNTDAGLLT 473

Query: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIV 975
             V  L P   Y   V+          S T    T + VP  P      V  + +   I +
Sbjct: 474  TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR---IQL 530

Query: 976  NWQ-PPSEANGKITGY-IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQ 1033
            +W  PP E   +I  Y ++Y++ +   + H    +P      ++ +++L  DT Y F++ 
Sbjct: 531  SWLLPPQE---RIIMYELVYWAAEDEDQQHKVTFDPTS----SYTLEDLKPDTLYRFQLA 583

Query: 1034 ARNSKGMGPMSEAVQFRTPKADSS 1057
            AR+  G+G  +  ++ RT ++  S
Sbjct: 584  ARSDMGVGVFTPTIEARTAQSTPS 607


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  247 bits (630), Expect = 7e-65
 Identities = 255/1033 (24%), Positives = 423/1033 (40%), Gaps = 122/1033 (11%)

Query: 64   SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL--PDGSLFISNVVHSKHNK 121
            ++ G    ++C     P   I+W K+    NL+  + RQ+    +G+L +S+V      +
Sbjct: 515  AIAGRDTYIHCRVIGYPYYSIKWYKNS---NLLPFNHRQVAFENNGTLKLSDV----QKE 567

Query: 122  PDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEV-NADLV 180
             DEG Y C   V+    + +  +  +   +P F    E      G    + C V + DL 
Sbjct: 568  VDEGEYTCNVLVQP--QLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLP 625

Query: 181  PFVRWEQNRQPL-----LLDDRVIKLPSGMLVISNATEGDGGLYRCVVES-GGPPKYSDE 234
              + W+++ +P+     +  D +    S  L ISN +    G Y C+  +     ++  +
Sbjct: 626  ITITWQKDGRPIPGSLGVTIDNIDFTSS--LRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683

Query: 235  VELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEA-----L 289
            + ++V P         F+ QP     + G+ V+L C A G P PTI W  ++ A      
Sbjct: 684  LIVRVPPK--------FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQ 735

Query: 290  DTESSERLVLLAGGSLEISDVTEDDAGTYFC-IADNGNETIEAQAELTVQAQPEFLKQPT 348
                + R+ +L+ GSL I  V E+D+G Y C ++++    +     LTV+        P 
Sbjct: 736  PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPN 795

Query: 349  NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIP--SDYFKIVKE------HNLQVLGL 400
               A +       C   G+    V+W K   ++ P  + Y    KE        LQ+L  
Sbjct: 796  TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855

Query: 401  VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460
            V+ D GF+ C A N  G  +   QL + E         P  P ++    V  R I L W 
Sbjct: 856  VREDSGFFSCHAINSYGEDRGIIQLTVQE---------PPDPPEIEIKDVKARTITLRW- 905

Query: 461  TPASDPHGDNLTYSVFYTKEGIARERVENTSH--PGEMQVTIQNLMPATVYIFRVMAQNK 518
            T   D +     Y +    +  + +  + T    P     TI ++ P++ Y  R+ A+N+
Sbjct: 906  TMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 965

Query: 519  HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKLYY 576
             G  E S  L + T  E    GP   +     S  SI VTW+ P     NG I+ Y++ Y
Sbjct: 966  IGKSEPSNELTI-TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024

Query: 577  MEKGTDKEQD-----VDVSSHS--YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
             E  T          VD S  S  YT++ L K+T+Y   V A N+ G G S+ ++   TL
Sbjct: 1025 REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTL 1084

Query: 630  SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL-VS 688
             DVPS  P+N+     + +SI I W   +    NG + G+++ Y       ++ E   ++
Sbjct: 1085 EDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144

Query: 689  GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR 748
             TQ S  ++GL++ T Y+ +V A T  G G  ++ +   T E       VP  P+ +   
Sbjct: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKED------VPGPPAGVKAA 1198

Query: 749  PLVTSIV-VSWTPPENQNIVVRGYAIGYGIGSPHA-QTIKVDYKQRYYTIENLDPSSHYV 806
                S+V VSW PP   N ++R Y +      P      +       Y I NL  +  Y 
Sbjct: 1199 AASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258

Query: 807  ITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILS 866
            + + A  + G G             ++SE+   +   P    P            A IL+
Sbjct: 1259 VWVVAVTSAGRG-------------NSSEI---ITVEPLAKAP------------ARILT 1290

Query: 867  HD-TIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKP-NT 924
               T+   W  + +   + + D            PA    K++N T     + G +   +
Sbjct: 1291 FSGTVTTPWMKDIVLPCKAVGDPS----------PAVKWMKDSNGTPSLVTIDGRRSIFS 1340

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGT------TFELVPTSPPKDVTVVSKEGKPKTIIVNWQ 978
               F +   K   S  +S  A+           L    PP    +   +    +I ++W 
Sbjct: 1341 NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL 1400

Query: 979  PPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSK 1038
            P       I GYI+ YS D N+E   W   P+  +  +++++ L   T Y F + A+N  
Sbjct: 1401 PGDNGGSSIRGYILQYSED-NSE--QWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGV 1457

Query: 1039 GMGPMSEAVQFRT 1051
            G G +SE ++ +T
Sbjct: 1458 GPGRISEIIEAKT 1470



 Score =  154 bits (390), Expect = 5e-37
 Identities = 242/1056 (22%), Positives = 388/1056 (36%), Gaps = 152/1056 (14%)

Query: 52   PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
            P    + P    S  GS V L+CS       ++ W ++G  LN   + R   +   +L +
Sbjct: 313  PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIM 372

Query: 112  SNVVHSKHNKPDEGYYQCVATVESLG-------TIISRTAKLIVAGLPRFTSQPEPSSVY 164
             ++V     K D G YQC    + L         +   T K+I A   +  S  EP S  
Sbjct: 373  DHMV-----KSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVS-- 425

Query: 165  AGNNAILNCEVNADLVPFVRWEQNRQPLLL--DDRVIKLPS------GMLVISNATEGDG 216
                  L C V    +P + W  +  P+L     R+ ++ +        L IS++   DG
Sbjct: 426  ------LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479

Query: 217  GLYRCVV-ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGL 275
            G+YRC    S G   Y   + ++    P  I  +        +  + G+D  + C   G 
Sbjct: 480  GVYRCTANNSAGVVLYQARINVR---GPASIRPM------KNITAIAGRDTYIHCRVIGY 530

Query: 276  PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTED-DAGTYFCIADNGNETIEAQAE 334
            P  +IKW KN   L   +  ++     G+L++SDV ++ D G Y C     N  ++ Q  
Sbjct: 531  PYYSIKWYKNSNLLPF-NHRQVAFENNGTLKLSDVQKEVDEGEYTC-----NVLVQPQLS 584

Query: 335  LTVQAQPEFLKQPTNIYAHE------SMDIVFECEVTGKPTP-TVKWVKNGDMVIPS--- 384
             T Q+    +K P  I   E         +   C V     P T+ W K+G  +  S   
Sbjct: 585  -TSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGV 643

Query: 385  DYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRD 444
                I    +L++  L     G Y CIA N+    +  +QLI+    P      P     
Sbjct: 644  TIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV--RVPPKFVVQPRDQDG 701

Query: 445  VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQV------ 498
            +    V                 G  +   V+   +G    + +  +  G +QV      
Sbjct: 702  IYGKAVILN----------CSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSL 751

Query: 499  TIQNLMPATVYIFRVMAQNKHGSGESSA-------PLRVETQPEVQL--PGPAPNLRAYA 549
             I++++      +     N  G+  S +       P  + + P   L   G    +   A
Sbjct: 752  LIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTA 811

Query: 550  ASPTSITVTWETPVS-GNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFR 608
                 I V WE      N E+  Y +   E G +    + +       +G        F 
Sbjct: 812  HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-------FS 864

Query: 609  VVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITG 668
              A N +G       + V+   D P        +E+++ K+  I  +       N  ITG
Sbjct: 865  CHAINSYGEDRGIIQLTVQEPPDPP-------EIEIKDVKARTITLRWTMGFDGNSPITG 917

Query: 669  YKIR-------YRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPAT 721
            Y I        +  A R  DV+  L S T     I  +   + Y+ R+ A    G    +
Sbjct: 918  YDIECKNKSDSWDSAQRTKDVSPQLNSAT-----IIDIHPSSTYSIRMYAKNRIGKSEPS 972

Query: 722  DWLSAETFESDLDETRVPEVPSSLHVRPLVT-SIVVSWTPPEN--QNIVVRGYAIGYGI- 777
            + L+        DE      P  +H+ P+ + SI V+W  P+   QN ++RGY IGY   
Sbjct: 973  NELTITA-----DEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027

Query: 778  ---GSPHAQTIKVDYK--QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTD 832
               G+     I VD       YT++NL+  + Y + ++A N  G G P  +  +T    D
Sbjct: 1028 STGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLED 1086

Query: 833  TSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYT 892
                                P  PP  VQA   S ++I I+W+  S      I    +  
Sbjct: 1087 -------------------VPSYPPENVQAIATSPESISISWSTLSKEALNGILQG-FRV 1126

Query: 893  VRWKTNIPANT-KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFE 951
            + W   +     + KN   T  S  + GL+  T Y   V+          S      T E
Sbjct: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186

Query: 952  LVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVV 1011
             VP  PP  V   +       + V+W PP + NG I  Y ++ S      I ++   P  
Sbjct: 1187 DVP-GPPAGVKAAA--ASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-- 1241

Query: 1012 GNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047
             +  +++I  L+ +  Y   + A  S G G  SE +
Sbjct: 1242 -DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276



 Score =  133 bits (335), Expect = 1e-30
 Identities = 242/1062 (22%), Positives = 410/1062 (38%), Gaps = 187/1062 (17%)

Query: 64   SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD 123
            ++ G  V L C A   P P   W KD   L L    ++ +     L I N+  S     D
Sbjct: 236  AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT---GLLIENIRPS-----D 287

Query: 124  EGYYQC-VATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF 182
             G Y C V+       +I R   L V    + T  P       G+   L+C V       
Sbjct: 288  SGSYVCEVSNRYGTAKVIGR---LYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQE 344

Query: 183  VRWEQNRQPLL--LDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 240
            + W +N + L    + R+  +    L++ +  + DGG Y+C V      K S +  ++V+
Sbjct: 345  LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD---KLSAQDYVQVV 401

Query: 241  PD---PEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERL 297
             +   P++IS        S  V    + V L C   G P PTI W  +++ +    S R+
Sbjct: 402  LEDGTPKIISAF------SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455

Query: 298  --VLLAGGS----LEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIY 351
              ++ + G+    L IS     D G Y C A+N    +  QA + V+  P  ++   NI 
Sbjct: 456  SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNIT 514

Query: 352  AHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN--LQVLGLVKS-DEGFY 408
            A    D    C V G P  ++KW KN ++ +P ++ ++  E+N  L++  + K  DEG Y
Sbjct: 515  AIAGRDTYIHCRVIGYPYYSIKWYKNSNL-LPFNHRQVAFENNGTLKLSDVQKEVDEGEY 573

Query: 409  QC--IAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466
             C  + +  +  +Q+   + +    P    P    PR  +   V   FI      P    
Sbjct: 574  TCNVLVQPQLSTSQS---VHVTVKVPPFIQPF-EFPRFSIGQRV---FI------PCVVV 620

Query: 467  HGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNL-MPATVYI----------FRVMA 515
             GD L  ++ + K+G           PG + VTI N+   +++ I          +  +A
Sbjct: 621  SGD-LPITITWQKDG--------RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671

Query: 516  QNKHGSGESSAPLRVETQPE--VQ------LPGPAPNLRAYAASPTSITVTWE------- 560
            +N+  + E  + L V   P+  VQ      + G A  L   A      T+ W+       
Sbjct: 672  RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731

Query: 561  ---TPVSGNGEIQ---NYKL-----------YYMEKGTDKEQDVDVSSHSY-TINGLKKY 602
                P++ NG IQ   N  L           YY+ K    +   DVS   Y T+      
Sbjct: 732  PQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCK-VSNDVGADVSKSMYLTVKIPAMI 790

Query: 603  TEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQ 662
            T Y                P+  + T         + +S      K I++ W+      +
Sbjct: 791  TSY----------------PNTTLAT-----QGQKKEMSCTAHGEKPIIVRWE-----KE 824

Query: 663  NGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722
            +  I     RY  +++  +V E ++S  Q+   +    R     F   A+   G      
Sbjct: 825  DRIINPEMARYLVSTK--EVGEEVISTLQILPTV----REDSGFFSCHAINSYGEDRGII 878

Query: 723  WLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIGYGIGSPH 781
             L+ +           P  P  + ++ +   +I + WT   + N  + GY I     S  
Sbjct: 879  QLTVQE----------PPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDS 928

Query: 782  ----AQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVD 837
                 +T  V  +    TI ++ PSS Y I + A N +G+  P  E  +T          
Sbjct: 929  WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT---------- 978

Query: 838  LFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKT 897
                        +  P  PP  V    +S  +IR+TW   +  KH +    R Y + ++ 
Sbjct: 979  ----------ADEAAPDGPPQEVHLEPISSQSIRVTW--KAPKKHLQNGIIRGYQIGYRE 1026

Query: 898  -----NIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL 952
                 N   N    + +  +  Y +  L   T Y   V       +   S     TT E 
Sbjct: 1027 YSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLED 1086

Query: 953  VPTSPPKDVTVVSKEGKPKTIIVNWQPPSE--ANGKITGY-IIYYSTDVNAEIHDWVIEP 1009
            VP+ PP++V  ++    P++I ++W   S+   NG + G+ +IY++  ++ E+ +  I+ 
Sbjct: 1087 VPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGE--IKN 1142

Query: 1010 VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
            +   + + ++  L   T Y  ++ A    G G  SE +  RT
Sbjct: 1143 ITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184



 Score =  130 bits (328), Expect = 7e-30
 Identities = 202/847 (23%), Positives = 325/847 (38%), Gaps = 119/847 (14%)

Query: 34   ARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKD---- 89
            AR+ +A     + +    P  F+V+P D   + G +VILNCSA   P P I WK      
Sbjct: 671  ARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730

Query: 90   -GTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV 148
               F  +  + R Q+L +GSL I +VV     + D GYY C  +   +G  +S++  L V
Sbjct: 731  VPQFQPIALNGRIQVLSNGSLLIKHVV-----EEDSGYYLCKVS-NDVGADVSKSMYLTV 784

Query: 149  AGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVI 208
                  TS P  +    G    ++C  + +    VRWE+       +DR+I       ++
Sbjct: 785  KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK-------EDRIINPEMARYLV 837

Query: 209  SNATEG---------------DGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDLVFL 252
            S    G               D G + C  + S G  +   ++ ++  PDP  I      
Sbjct: 838  STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVK 897

Query: 253  KQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTE 312
             +   L   +G D   P          I+     ++ D+    + V     S  I D+  
Sbjct: 898  ARTITLRWTMGFDGNSPITGY-----DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHP 952

Query: 313  DDAGTYFCIADNGNETIEAQAELTV---QAQPEFLKQPTNIYAHESMDIVFECEVTGKPT 369
                +    A N     E   ELT+   +A P+   Q  ++    S  I     VT K  
Sbjct: 953  SSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI----RVTWKAP 1008

Query: 370  PTVKWVKNGDM-VIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
               K ++NG +      Y +     N Q   ++  D      +   D  N      L++ 
Sbjct: 1009 K--KHLQNGIIRGYQIGYREYSTGGNFQ-FNIISVDTSGDSEVYTLDNLNKFTQYGLVVQ 1065

Query: 429  EHAPATTGP------------LPS-APRDVVASLVSTRFIKLTWRTPASDP-HGDNLTYS 474
                A TGP            +PS  P +V A   S   I ++W T + +  +G    + 
Sbjct: 1066 ACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFR 1125

Query: 475  VFYTKEGIARERVE----NTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530
            V Y    +  E  E     T+ P    + +  L   T Y  +V+A  + G G  S  +  
Sbjct: 1126 VIYWANLMDGELGEIKNITTTQP---SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT 1182

Query: 531  ETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLY--YMEKGTDKEQDVD 588
             T+ +V  PGP   ++A AAS + + V+W  P+  NG I+ Y ++  +       E +  
Sbjct: 1183 RTKEDV--PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEAS 1240

Query: 589  VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSK 648
              S SY I  L +  +YS  VVA    G G S+  + V  L+  P+         +  S 
Sbjct: 1241 PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI-------LTFSG 1293

Query: 649  SIMIHWQ-----------PPAPATQ-----NGQITGYKIRYRKASRKSDVTETLVSGTQL 692
            ++   W             P+PA +     NG  +   I  R++           +G+ +
Sbjct: 1294 TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS--------IFSNGSFI 1345

Query: 693  SQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVT 752
             + ++  D G  Y   +A           +W S E    +L     P+ P     +   +
Sbjct: 1346 IRTVKAEDSG--YYSCIA---------NNNWGSDEII-LNLQVQVPPDQPRLTVSKTTSS 1393

Query: 753  SIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKA 811
            SI +SW P +N    +RGY + Y    S    +  +   +R Y +ENL   + Y  TL A
Sbjct: 1394 SITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453

Query: 812  FNNVGEG 818
             N VG G
Sbjct: 1454 QNGVGPG 1460



 Score =  105 bits (262), Expect = 3e-22
 Identities = 103/400 (25%), Positives = 161/400 (40%), Gaps = 38/400 (9%)

Query: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
           Q+ P      S ++H      D  YY C A   S G I S+   +       +T + E  
Sbjct: 82  QIFPFPPSSFSTLIH------DNTYY-CTAENPS-GKIRSQDVHIKAVLREPYTVRVEDQ 133

Query: 162 SVYAGNNAILNCEVNADL---VPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGL 218
               GN A+  C + + +   +  V WE++   L+   R +   +G L I +    DG  
Sbjct: 134 KTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLY 193

Query: 219 -YRCVVESG--GPPKYSDEVELKVLPD----PEVISDLVFLKQPSPLVRVIGQDVVLPCV 271
            YRC+      G  + S+   L V       P ++      K       + GQ V LPC 
Sbjct: 194 NYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKA------MAGQRVELPCK 247

Query: 272 ASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEA 331
           A G P P  +W+K+   L  E S R      G L I ++   D+G+Y C   N   T + 
Sbjct: 248 ALGHPEPDYRWLKDNMPL--ELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKV 304

Query: 332 QAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKI-- 389
              L V+   +    P  + +     +   C VTG     + W +NG+++ P    +I  
Sbjct: 305 IGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364

Query: 390 VKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL------PSAPR 443
           +   NL +  +VKSD G YQC    D  +AQ   Q+++ +  P            P+ P 
Sbjct: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424

Query: 444 DVVASLVSTRFIKLTWRTPASDP--HGDNLTYSVFYTKEG 481
            ++ ++  T    +TW T   DP   G +   S   T EG
Sbjct: 425 SLMCNVKGTPLPTITW-TLDDDPILKGGSHRISQMITSEG 463



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 79/335 (23%), Positives = 132/335 (39%), Gaps = 20/335 (5%)

Query: 322  ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD-- 379
            A  GN +     E   +A    L     +      DIV  C+  G P+P VKW+K+ +  
Sbjct: 1267 AGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGT 1326

Query: 380  -MVIPSDYFKIVKEHNLQVLGLVKS-DEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
              ++  D  + +  +   ++  VK+ D G+Y CIA N+ G+ +    L +    P     
Sbjct: 1327 PSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV--QVP----- 1379

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
             P  PR  V+   S+  I L+W     D  G ++   +    E  + +       P E  
Sbjct: 1380 -PDQPRLTVSKTTSSS-ITLSWL--PGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
              ++NL   T Y F + AQN  G G  S  +  +T  +         L A + + T + +
Sbjct: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFA-SINTTRVRL 1494

Query: 558  TWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVS--SHSYTINGLKKYTEYSFRVVAYNKH 615
                   G   I ++ L Y   GT        +  S SY +  L++ T Y  ++   N  
Sbjct: 1495 NLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSA 1554

Query: 616  GPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSI 650
            G      + A  TL+   S  P  +   V+N + +
Sbjct: 1555 GCAEKQANFA--TLNYDGSTIPPLIKSVVQNEEGL 1587



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 88/431 (20%), Positives = 161/431 (37%), Gaps = 32/431 (7%)

Query: 394  NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTR 453
            +L++ GL K      Q +A    G+     Q+        T   +P  P  V A+  S  
Sbjct: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT-----RTKEDVPGPPAGVKAAAASAS 1203

Query: 454  FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
             + ++W  P    +G    Y+VF +         E  + P      I NL     Y   V
Sbjct: 1204 MVFVSWLPPLK-LNGIIRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWV 1261

Query: 514  MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK 573
            +A    G G SS  + VE  P  + P           +P    +       G+      K
Sbjct: 1262 VAVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPS-PAVK 1318

Query: 574  LYYMEKGTDKEQDVD-----VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT 628
                  GT     +D      S+ S+ I  +K      +  +A N  G    + ++ +  
Sbjct: 1319 WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILNL 1374

Query: 629  LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNG--QITGYKIRYRKASRKSDVTETL 686
               VP   P+ L++    S SI + W P      NG   I GY ++Y +           
Sbjct: 1375 QVQVPPDQPR-LTVSKTTSSSITLSWLPG----DNGGSSIRGYILQYSE-DNSEQWGSFP 1428

Query: 687  VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
            +S ++ S  +E L  GT Y F + A    G G  ++ + A+T   +   ++  E+ +S++
Sbjct: 1429 ISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASIN 1488

Query: 747  VRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQRYYTIENLDPSSHY 805
               +  ++ + W    +    +  + + Y   G+    T +     + Y + +L  ++ Y
Sbjct: 1489 TTRVRLNL-IGW---NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWY 1544

Query: 806  VITLKAFNNVG 816
             + ++  N+ G
Sbjct: 1545 ELQMRVCNSAG 1555



 Score = 37.7 bits (86), Expect = 0.082
 Identities = 43/190 (22%), Positives = 80/190 (42%), Gaps = 26/190 (13%)

Query: 267 VLPCVASGLPTPTIKW--MKNEEALDTESSERLVLLAGGSLEI------SDVTEDDAGTY 318
           ++PC A+G+P  T++W     EE  D        +   G+L+I      S  T     TY
Sbjct: 43  LVPCPAAGIPPVTLRWYLATGEEIYDVPGIRH--VHPNGTLQIFPFPPSSFSTLIHDNTY 100

Query: 319 FCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDI-----VFECEVTGKP---TP 370
           +C A+N +  I +Q ++ ++A    L++P  +   +   +     VF+C +         
Sbjct: 101 YCTAENPSGKIRSQ-DVHIKA---VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT 156

Query: 371 TVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGF--YQCIAEND-VGNAQAGAQLII 427
            V W K+   ++    F I     L +   V++++G   Y+CI  +   G  +      +
Sbjct: 157 VVSWEKDTVSLVSGSRFLITSTGALYIKD-VQNEDGLYNYRCITRHRYTGETRQSNSARL 215

Query: 428 LEHAPATTGP 437
               PA + P
Sbjct: 216 FVSDPANSAP 225


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  244 bits (624), Expect = 3e-64
 Identities = 283/1055 (26%), Positives = 431/1055 (40%), Gaps = 140/1055 (13%)

Query: 55   FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP--DGSLFIS 112
            F+  P D   + G      C A  EP P+I W K G     VS  R +++   DG+  + 
Sbjct: 35   FIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKG---KKVSSQRFEVIEFDDGAGSVL 91

Query: 113  NVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA-------GLPRFTSQPEPSSVYA 165
             +   +  + DE  Y+C AT  SLG I + +AKL V        G P     P+   V  
Sbjct: 92   RIQPLRVQR-DEAIYECTAT-NSLGEI-NTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEK 148

Query: 166  GNNAILNCEVNADLVPFVRWEQNRQPL---LLDDRVIKLPSGMLVISNATEGDGGLYRCV 222
               A + C    +  P + W ++  P+     + R+ +L SG L I ++ E D G Y CV
Sbjct: 149  ARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECV 208

Query: 223  VESGGPPKYSDEVEL-----KVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPT 277
              +    +YS    L     +V P         F   PS    + G  V L CVA G P 
Sbjct: 209  ATNSAGTRYSAPANLYVRVRRVAPR--------FSIPPSSQEVMPGGSVNLTCVAVGAPM 260

Query: 278  PTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTV 337
            P +KWM   E L  E     + +    LE+S+V    +  Y C+A +    IEA A++TV
Sbjct: 261  PYVKWMMGAEELTKEDE---MPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTV 315

Query: 338  QAQPEFLKQPTNIYAHE----SMDIVFECEVTGKPTPTVKW---VKNGDMVIPSDYFKIV 390
            +A P   K P ++   E    S+ + ++   +G   P   +    +      P      V
Sbjct: 316  KALP---KPPIDLVVTETTATSVTLTWD---SGNSEPVTYYGIQYRAAGTEGPFQEVDGV 369

Query: 391  KEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL--PSAPRDVVAS 448
                  + GL    E  ++ +A N +G           E   A TG     S PR V A 
Sbjct: 370  ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPS------EAVRARTGEQAPSSPPRRVQAR 423

Query: 449  LVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSH----PGEMQVTIQNLM 504
            ++S   + + W  P  +P+G    Y V+YT +     R  N  H       +  T+ +L+
Sbjct: 424  MLSASTMLVQWE-PPEEPNGLVRGYRVYYTPDS---RRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 505  PATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVS 564
            P   Y  RV+A    G G  S  ++V+TQ  V  P    + +A   S T I ++W  P  
Sbjct: 480  PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV--PAQPADFQAEVESDTRIQLSWLLP-- 535

Query: 565  GNGEIQNYKLYYMEKGTDKEQDVDVS---SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
                I  Y+L Y     D++Q   V+   + SYT+  LK  T Y F++ A +  G GV T
Sbjct: 536  PQERIIMYELVYW-AAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
            P +  RT    PSA PQ +      S ++ + W PP   ++NG IT Y + Y     +  
Sbjct: 595  PTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDR 654

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
                +  +S    S  + GL++ TEY   V A T  G GP +  +   T     DE    
Sbjct: 655  GRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT-----DEDVPS 709

Query: 740  EVPSSLHVRPL-VTSIVVSW--TPPENQNIVVRGYAIGY-------GIGSPHAQTIKV-- 787
              P  + V PL  T++ V W    P  Q+  +RGY + Y         G P  Q + +  
Sbjct: 710  GPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769

Query: 788  ---------DYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDL 838
                     DY+    TI  L P + Y +T+ A+   G+G      A ++P   T+    
Sbjct: 770  AQWRPEESEDYET---TISGLTPETTYSVTVAAYTTKGDG------ARSKPKIVTTT--- 817

Query: 839  FVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTN 898
                     VP    MM       S  + +T  + W     P  +   +   Y +++   
Sbjct: 818  -------GAVPGRPTMM------ISTTAMNTALLQWH----PPKELPGELLGYRLQYCRA 860

Query: 899  IPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPP 958
              A     +       + VTGL   T Y F  +  K R            T E +P+  P
Sbjct: 861  DEARPNTIDFGKDDQHFTVTGLHKGTTYIFR-LAAKNRAGLGEEFEKEIRTPEDLPSGFP 919

Query: 959  KDVTVVSKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT 1016
            +++ V        T  + W PP  +E NG+I  Y + +  D+N++    +       R T
Sbjct: 920  QNLHVTGL--TTSTTELAWDPPVLAERNGRIISYTVVF-RDINSQ--QELQNITTDTRFT 974

Query: 1017 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
              +  L  DT Y  K++A  SKG GP+S ++Q RT
Sbjct: 975  --LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT 1007



 Score =  206 bits (523), Expect = 2e-52
 Identities = 230/969 (23%), Positives = 388/969 (40%), Gaps = 119/969 (12%)

Query: 138  TIISRTAKLIVAGL---------PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRW-EQ 187
            T++     L++ GL         P F   PE  +  +G  A   C+   +  P + W ++
Sbjct: 10   TMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKK 69

Query: 188  NRQPLLLDDRVIKLPSG----MLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDP 243
             ++       VI+   G    + +     + D  +Y C   +    + +   +L VL + 
Sbjct: 70   GKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTA-TNSLGEINTSAKLSVLEEE 128

Query: 244  EVISDLVFLKQPSPLVRVI--GQDVVLPCVASGLPTPTIKWMKNEEALDTESSE-RLVLL 300
            ++      +    P ++V+   +   + C A G P P I W K+   +D  +S  R+  L
Sbjct: 129  QLPPGFPSIDM-GPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQL 187

Query: 301  AGGSLEISDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQ---PEFLKQPTNIYAHESM 356
              G+L+I    E D G Y C+A N   T   A A L V+ +   P F   P++       
Sbjct: 188  RSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGG 247

Query: 357  DIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDV 416
             +   C   G P P VKW+   + +   D    V  + L++  +V+S    Y C+A + +
Sbjct: 248  SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMP-VGRNVLELSNVVRSAN--YTCVAISSL 304

Query: 417  GNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVF 476
            G  +A AQ+        T   LP  P D+V +  +   + LTW +  S+P    +TY   
Sbjct: 305  GMIEATAQV--------TVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGI 352

Query: 477  YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
              +        +        + +I  L P + Y FRV+A N  G G  S  +R  T  + 
Sbjct: 353  QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412

Query: 537  QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSY-- 594
                P   ++A   S +++ V WE P   NG ++ Y++YY    T   +    + H +  
Sbjct: 413  P-SSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYY----TPDSRRPPNAWHKHNT 467

Query: 595  ------TINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSK 648
                  T+  L     YS RV+A+   G G  +P + V+T   VP A P +   EV +  
Sbjct: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQAEVESDT 526

Query: 649  SIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFR 708
             I + W  P       +I  Y++ Y  A+   D    +      S  +E L   T Y F+
Sbjct: 527  RIQLSWLLP----PQERIIMYELVY-WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQ 581

Query: 709  VAALTINGTGPATDWLSAETFESDLDETRVPEVPSS--LHVRPLVTSIVVSWTPP--ENQ 764
            +AA +  G G  T  + A T +S       P  P    + V    T++ VSW PP  +++
Sbjct: 582  LAARSDMGVGVFTPTIEARTAQS------TPSAPPQKVMCVSMGSTTVRVSWVPPPADSR 635

Query: 765  NIVVRGYAIGYGI--GSPHAQTI--KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP 820
            N V+  Y++ Y    G    + +   +  +   + +  L+  + Y + ++A  +VG G  
Sbjct: 636  NGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG-- 693

Query: 821  LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP 880
              ES+     TD                 +  P  PP  V+   L+   + + W    LP
Sbjct: 694  -PESSPVLVRTD-----------------EDVPSGPPRKVEVEPLNSTAVHVYW---KLP 732

Query: 881  ----KHQKITDSRYYTVRWKTNIP-----------ANTKYKNANATTLSYLVTGLKPNTL 925
                +H +I   +   VR +   P           A  +++   +      ++GL P T 
Sbjct: 733  VPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETT 792

Query: 926  YEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANG 985
            Y  +V     +     S     TT   VP  P    T++       T ++ W PP E  G
Sbjct: 793  YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP----TMMISTTAMNTALLQWHPPKELPG 848

Query: 986  KITGYIIYYSTDVNAEIHDWVIEPVVGNRLTH-QIQELTLDTPYYFKIQARNSKGMGPMS 1044
            ++ GY + Y     A  +   I+   G    H  +  L   T Y F++ A+N  G+G   
Sbjct: 849  ELLGYRLQYCRADEARPN--TID--FGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904

Query: 1045 EAVQFRTPK 1053
            E  + RTP+
Sbjct: 905  EK-EIRTPE 912



 Score =  151 bits (382), Expect = 4e-36
 Identities = 149/636 (23%), Positives = 254/636 (39%), Gaps = 73/636 (11%)

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
            +P+ P D  A + S   I+L+W  P   P    + Y + Y       ++ + T  P    
Sbjct: 511  VPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAAEDEDQQHKVTFDPTS-S 566

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
             T+++L P T+Y F++ A++  G G  +  +   T        P   +   +   T++ V
Sbjct: 567  YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTP-SAPPQKVMCVSMGSTTVRV 625

Query: 558  TWETPV--SGNGEIQNYKLYYM-----EKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVV 610
            +W  P   S NG I  Y + Y      ++G      +     S+ + GL+K+TEY   V 
Sbjct: 626  SWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVR 685

Query: 611  AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
            A+   GPG  +  V VRT  DVPS  P+ + +E  NS ++ ++W+ P P+ Q+GQI GY+
Sbjct: 686  AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745

Query: 671  IRYRKASRKSDVTETLVSGTQLSQ-------------LIEGLDRGTEYNFRVAALTINGT 717
            + Y +          ++    L++              I GL   T Y+  VAA T  G 
Sbjct: 746  VTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805

Query: 718  GPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-G 776
            G  +      T  +      VP  P+ +     + + ++ W PP+     + GY + Y  
Sbjct: 806  GARSKPKIVTTTGA------VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859

Query: 777  IGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEV 836
                   TI      +++T+  L   + Y+  L A N  G G    +   T         
Sbjct: 860  ADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT--------- 910

Query: 837  DLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK 896
                        P+  P   P  +  + L+  T  + W    L +      S  YTV ++
Sbjct: 911  ------------PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS--YTVVFR 956

Query: 897  TNIPANTKYKNANATT-LSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPT 955
                 N++ +  N TT   + +TGLKP+T Y+  V     + S   S +    T   V  
Sbjct: 957  ---DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMP-VEQ 1012

Query: 956  SPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRL 1015
               K+  V +      +++++W+ P      +   I+Y    V  +          G+ +
Sbjct: 1013 VFAKNFRVAA--AMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVD----------GHSM 1060

Query: 1016 THQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
               I +L  +T Y F +  R S   G +   V  RT
Sbjct: 1061 RKLIADLQPNTEYSFVLMNRGSSA-GGLQHLVSIRT 1095



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 78/324 (24%), Positives = 126/324 (38%), Gaps = 38/324 (11%)

Query: 738  VPEVPSSLHV-RPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVD-YKQRYYT 795
            +P+ P  L V     TS+ ++W    ++ +    Y I Y          +VD      Y+
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTY--YGIQYRAAGTEGPFQEVDGVATTRYS 375

Query: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMM 855
            I  L P S Y   + A N++G G P   S   R  T                  +  P  
Sbjct: 376  IGGLSPFSEYAFRVLAVNSIGRGPP---SEAVRARTG-----------------EQAPSS 415

Query: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSY 915
            PP  VQA +LS  T+ + W     P         YYT    +  P N  +K+     L  
Sbjct: 416  PPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP--DSRRPPNAWHKHNTDAGLLT 473

Query: 916  LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIV 975
             V  L P   Y   V+          S T    T + VP  P      V  + +   I +
Sbjct: 474  TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR---IQL 530

Query: 976  NWQ-PPSEANGKITGY-IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQ 1033
            +W  PP E   +I  Y ++Y++ +   + H    +P      ++ +++L  DT Y F++ 
Sbjct: 531  SWLLPPQE---RIIMYELVYWAAEDEDQQHKVTFDPTS----SYTLEDLKPDTLYRFQLA 583

Query: 1034 ARNSKGMGPMSEAVQFRTPKADSS 1057
            AR+  G+G  +  ++ RT ++  S
Sbjct: 584  ARSDMGVGVFTPTIEARTAQSTPS 607


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  244 bits (623), Expect = 4e-64
 Identities = 258/1029 (25%), Positives = 421/1029 (40%), Gaps = 111/1029 (10%)

Query: 64   SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL-PDGSLFISNVVHSKHNKP 122
            +V G   ++NC     P   I+W KD     L+ D+ RQ++  +G+L +++V        
Sbjct: 576  AVAGRDTLINCRVIGYPYYSIKWYKDAL---LLPDNHRQVVFENGTLKLTDVQKGM---- 628

Query: 123  DEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP---EPSSVYAGNNAILNCEVNADL 179
            DEG Y C   ++   +I S++  + V   P    QP    P+S+  G    + C V++  
Sbjct: 629  DEGEYLCSVLIQPQLSI-SQSVHVAVKVPPLI--QPFEFPPASI--GQLLYIPCVVSSGD 683

Query: 180  VPF-VRWEQNRQPLLLDDRVI---KLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEV 235
            +P  + W ++ Q ++    V    K     L IS+ +    G Y C+  S      S E 
Sbjct: 684  MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA-SNAAATVSRER 742

Query: 236  ELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES-- 293
            +L V   P       F+ QP+    + G+  VL C   G P P + W   + + + +   
Sbjct: 743  QLIVRVPPR------FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH 796

Query: 294  ----SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQPEFLKQPT 348
                + R+ +L   SL I  V E+D G Y C A NG  T I     LTV+        P 
Sbjct: 797  PVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPN 856

Query: 349  NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVK-- 402
               A +       C   G+    ++W K GD VI  D    Y    K++  +V+  +K  
Sbjct: 857  TTIAIKGHAKELNCTARGERPIIIRWEK-GDTVIDPDRVMRYAIATKDNGDEVVSTLKLK 915

Query: 403  ----SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
                 D  F+ C A N  G  +   QL + E         P  P ++    V  R + L 
Sbjct: 916  PADRGDSVFFSCHAINSYGEDRGLIQLTVQE---------PPDPPELEIREVKARSMNLR 966

Query: 459  WRTPASDPHGDNLTYSVFYTKEGIARERVENTSH--PGEMQVTIQNLMPATVYIFRVMAQ 516
            W T   D +     + + Y  +  + +  ++T +  P   Q  I +L PA+VY  R+ + 
Sbjct: 967  W-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025

Query: 517  NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKL 574
            NK G  E S  L + T+ E    GP  ++     +  SI VTW+ P     NG I+ Y++
Sbjct: 1026 NKIGRSEPSKELTISTE-EAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084

Query: 575  YYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
             Y E          +        S  YT++ LKK+ +Y   V A+N+ G G S+ ++   
Sbjct: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINAT 1144

Query: 628  TLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL- 686
            TL DVPS  P+N+      S   +I W  P  +T NG + GY++ +       +  E   
Sbjct: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204

Query: 687  VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
            ++ T+    + G+++ T Y+ +V A T  G G  +  L  +T E       VP  P+ + 
Sbjct: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED------VPGPPAGIK 1258

Query: 747  VRP-LVTSIVVSWTPPENQNIVVRGYAI---GYGIGSPHAQTIKVDYKQRYYTIENLDPS 802
              P   +S+VVSW PP   N V+R Y I     G G P     +   +Q +Y I +L+  
Sbjct: 1259 AVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRG 1318

Query: 803  SHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQA 862
              Y++ + A  + G G       VT      +   +       T     TP M  V +  
Sbjct: 1319 QQYLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGGTVT-----TPWMKDVRLPC 1371

Query: 863  SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKP 922
            + +      + W  +S        DS          IP +        T  + L+  +K 
Sbjct: 1372 NSVGDPAPAVKWTKDS-------EDSA---------IPVSMDGHRLIHTNGTLLLRAVKA 1415

Query: 923  NTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE 982
                 ++   T      T           L+   PP    +   +    +I + W P   
Sbjct: 1416 EDSGYYTCTATNTGGFDT-------IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDN 1468

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
                I G+++ YS D N+E  +W    +  +  + ++  L   T Y  K+ A+NS G G 
Sbjct: 1469 GGSSIRGFVLQYSVD-NSE--EWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525

Query: 1043 MSEAVQFRT 1051
            +SE ++ +T
Sbjct: 1526 ISEIIEAKT 1534



 Score =  145 bits (366), Expect = 3e-34
 Identities = 245/1067 (22%), Positives = 409/1067 (38%), Gaps = 136/1067 (12%)

Query: 36   SGSAPQSPGASIRTFTPFYFLVEPVDTLSVR----GSSVILNCSAYSEPSPKIEWKKDGT 91
            SG   QS GA +    P   +   +D    +    G +V L C+A   P P I W KDG 
Sbjct: 265  SGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGR 324

Query: 92   FLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL 151
               L +D R       +  I+ +  S     D G Y C  T  + G+    T  L+V   
Sbjct: 325  --PLPADSR------WTKRITGLTISDLRTEDSGTYICEVT-NTFGSA-EATGILMVIDP 374

Query: 152  PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVI--KLPSGMLVIS 209
               T  P+      G+  IL+C +       +RW +N + +L D+ +    L +  L+I+
Sbjct: 375  LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLIT 434

Query: 210  NATEGDGGLYRCVVESGGPPKYSDEVELKVLPD--PEVISDLVFLKQPSPLVRVIGQDVV 267
            +A +   G Y+C        + + +  +  L D  P ++S        S  V   G+   
Sbjct: 435  SAQKSHSGAYQCFATRKA--QTAQDFAIIALEDGTPRIVSSF------SEKVVNPGEQFS 486

Query: 268  LPCVASGLPTPTIKWMKNEEALDTESSER---LVLLAGGSLEISDVTED---DAGTYFCI 321
            L C A G P PT+ W  ++E +  + S R     +  G ++   +VT     D G Y C 
Sbjct: 487  LMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCT 546

Query: 322  ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV 381
            A N   + E QA + V+  P  ++   NI A    D +  C V G P  ++KW K+  ++
Sbjct: 547  ARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA-LL 604

Query: 382  IPSDYFKIVKEHNLQVLGLVKS--DEGFYQC---------IAENDVGNAQAGAQLIILEH 430
            +P ++ ++V E+    L  V+   DEG Y C         I+++     +    +   E 
Sbjct: 605  LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF 664

Query: 431  APATTGPLPSAPRDVVASLVSTRFIKLTWRTPAS-DPHGDNLTYSVFYTKEGIARERVEN 489
             PA+ G L   P  VV+S      I++TWR        G  +T     +KE ++  ++ +
Sbjct: 665  PPASIGQLLYIP-CVVSS--GDMPIRITWRKDGQVIISGSGVTIE---SKEFMSSLQISS 718

Query: 490  TS--HPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQ--LPGPAPNL 545
             S  H G       N   ATV   R +            P R   QP  Q  + G A  L
Sbjct: 719  VSLKHNGNYTCIASN-AAATVSRERQLIVR--------VPPRFVVQPNNQDGIYGKAGVL 769

Query: 546  RAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEY 605
                       V W+    G+G  Q Y    +   T + Q +  S  S  I  + +    
Sbjct: 770  NCSVDGYPPPKVMWK-HAKGSGNPQQYHPVPL---TGRIQILPNS--SLLIRHVLEEDIG 823

Query: 606  SFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAP----------QNLSLEVRNSKSIMIHWQ 655
             +   A N  G  +S        +  + ++ P          + L+   R  + I+I W+
Sbjct: 824  YYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWE 883

Query: 656  PPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTIN 715
                     ++  Y I  +      +V  TL         ++  DRG    F   A+   
Sbjct: 884  KGDTVIDPDRVMRYAIATK--DNGDEVVSTL--------KLKPADRGDSVFFSCHAINSY 933

Query: 716  GTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIG 774
            G       L+ +           P  P  L +R +   S+ + WT   + N ++ G+ I 
Sbjct: 934  GEDRGLIQLTVQE----------PPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIE 983

Query: 775  YGIGSP----HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPH 830
            Y   S        T  +        I +L P+S Y I + +FN +G   P  E  ++   
Sbjct: 984  YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIS--- 1040

Query: 831  TDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRY 890
                               +  P  PP+ V    ++  +I++TW   +  K  +    R 
Sbjct: 1041 -----------------TEEAAPDGPPMDVTLQPVTSQSIQVTW--KAPKKELQNGVIRG 1081

Query: 891  YTVRWKTNIP-ANTKYK----NANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTA 945
            Y + ++ N P +N +Y      A   +  Y +  LK    Y   V       +   S   
Sbjct: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI 1141

Query: 946  HGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGY-IIYYSTDVNAEIHD 1004
            + TT E VP+ PP++V  +S       I  +  P S  NG + GY +I++S  V+ E  +
Sbjct: 1142 NATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGE 1201

Query: 1005 WVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
              ++ +   R   +++ +   T Y  ++ A    G G  S  +  +T
Sbjct: 1202 --MQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246



 Score =  125 bits (313), Expect = 4e-28
 Identities = 183/845 (21%), Positives = 337/845 (39%), Gaps = 111/845 (13%)

Query: 34   ARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWK------ 87
            A + +A  S    +    P  F+V+P +   + G + +LNCS    P PK+ WK      
Sbjct: 731  ASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSG 790

Query: 88   KDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLI 147
                +  +    R Q+LP+ SL I +V+     + D GYY C A+   +GT IS++  L 
Sbjct: 791  NPQQYHPVPLTGRIQILPNSSLLIRHVL-----EEDIGYYLCQAS-NGVGTDISKSMFLT 844

Query: 148  VAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKL-----P 202
            V      TS P  +    G+   LNC    +    +RWE+    ++  DRV++       
Sbjct: 845  VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG-DTVIDPDRVMRYAIATKD 903

Query: 203  SGMLVISN-----ATEGDGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256
            +G  V+S      A  GD   + C  + S G  +   ++ ++  PDP  + ++  +K  S
Sbjct: 904  NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPEL-EIREVKARS 962

Query: 257  PLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAG 316
              +R   Q      + +G     I++    ++ D + S R +        I D+      
Sbjct: 963  MNLRWT-QRFDGNSIITGF---DIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVY 1018

Query: 317  TYFCIADNGNETIEAQAELTV---QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVK 373
            +    + N     E   ELT+   +A P+       +    S  I    +VT K     K
Sbjct: 1019 SIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSI----QVTWKAPK--K 1072

Query: 374  WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ----------AGA 423
             ++NG          +++ + +          G Y  +     G+++          A  
Sbjct: 1073 ELQNG----------VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQY 1122

Query: 424  QLIILEHAPATTGP------------LPSAPRDVVASL-VSTRFIKLTW-RTPASDPHGD 469
             +++     A TGP            +PS P + V +L +++    ++W   P S  +G 
Sbjct: 1123 GVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGV 1182

Query: 470  NLTYSVFYTKEGIARE--RVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAP 527
               Y V +    +  E   ++N +   E +V ++ +   T Y  +V+A  + G G  S+ 
Sbjct: 1183 LKGYRVIFWSLYVDGEWGEMQNITTTRE-RVELRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241

Query: 528  LRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDK---- 583
            L ++T+ +V  PGP   ++A  +S +S+ V+W  P   NG I+ Y ++    G+ +    
Sbjct: 1242 LYIQTKEDV--PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPS 1299

Query: 584  EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLE 643
            E +       Y I  L +  +Y   V A    G G S+  V +      P+         
Sbjct: 1300 EYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKI------- 1352

Query: 644  VRNSKSIMIHWQPPA--PATQNGQITGYKIRYRKASRKSDVTETL-------VSGTQLSQ 694
            +    ++   W      P    G      +++ K S  S +  ++        +GT L +
Sbjct: 1353 ISFGGTVTTPWMKDVRLPCNSVGD-PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLR 1411

Query: 695  LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSI 754
             ++  D G              T  AT+    +T   +L     P+ P     +   +SI
Sbjct: 1412 AVKAEDSGYY------------TCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSI 1459

Query: 755  VVSWTPPENQNIVVRGYAIGYGI-GSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
             ++W P +N    +RG+ + Y +  S   + + +   +R + +++L   + Y + L A N
Sbjct: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKN 1519

Query: 814  NVGEG 818
            +VG G
Sbjct: 1520 SVGSG 1524



 Score =  113 bits (282), Expect = 2e-24
 Identities = 136/575 (23%), Positives = 221/575 (38%), Gaps = 70/575 (12%)

Query: 8   RRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRG 67
           RR+      WL   LLL         +   + P+  G S+      YF+ + +  ++   
Sbjct: 53  RRIGPLYGMWLVTFLLL-------LDSLHKARPEDVGTSL------YFVNDSLQQVTFSS 99

Query: 68  S-SVILNCSAYSEPSPKIEW---KKDGTF-----LNLVSDDRRQLLPDGSLFISNVVHSK 118
           S  V++ C A   PS  + W     D  +      ++ ++   QL P      ++ +H  
Sbjct: 100 SVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-- 157

Query: 119 HNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNAD 178
               D  Y+ C A   + G I S   ++       +T + E      GN A+  C + + 
Sbjct: 158 ----DNDYF-CTAE-NAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSS 211

Query: 179 L---VPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG-GLYRCVVES--GGPPKYS 232
           +   V  V WE++   ++ + R      G L IS+  + D    YRC+ +    G  + S
Sbjct: 212 VQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQS 271

Query: 233 DEVELKVLPDPEVISDLV--FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALD 290
           +   L V    E I  ++  F  Q        G  V LPC ASG P P I+W+K+   L 
Sbjct: 272 NGARLSVTDPAESIPTILDGFHSQEV----WAGHTVELPCTASGYPIPAIRWLKDGRPLP 327

Query: 291 TES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPT 348
            +S  ++R+       L ISD+  +D+GTY C   N   + EA   L V         P 
Sbjct: 328 ADSRWTKRIT-----GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK 382

Query: 349 NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKI--VKEHNLQVLGLVKSDEG 406
            +       ++  C +TG P  T++W +N ++V+P +   I  +    L +    KS  G
Sbjct: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSG 442

Query: 407 FYQCIAENDVGNAQAGAQLIILEHAPATTGPL------PSAPRDVVASLVSTRFIKLTWR 460
            YQC A      AQ  A + + +  P            P     ++ +        +TW 
Sbjct: 443 AYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502

Query: 461 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
                   D    +  YT        + + +    M VT   +    VY  R  A+N  G
Sbjct: 503 LDDEPIVRDGSHRTNQYT--------MSDGTTISHMNVTGPQIRDGGVY--RCTARNLVG 552

Query: 521 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
           S E  A + V   P ++      N+ A A   T I
Sbjct: 553 SAEYQARINVRGPPSIR---AMRNITAVAGRDTLI 584



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 77/309 (24%), Positives = 116/309 (37%), Gaps = 17/309 (5%)

Query: 322  ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNG-DM 380
            A  GN + +   E   +A  + +     +      D+   C   G P P VKW K+  D 
Sbjct: 1331 AGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDS 1390

Query: 381  VIP--SDYFKIVKEHNLQVLGLVKS-DEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
             IP   D  +++  +   +L  VK+ D G+Y C A N  G       L++    P     
Sbjct: 1391 AIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV--QVP----- 1443

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
             P  PR +  S  S   I LTW     D  G ++   V       + E  +      E  
Sbjct: 1444 -PDQPR-LTVSKTSASSITLTW--IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
              + +L   T Y  ++ A+N  GSG  S  +  +T           +L  +  S T   +
Sbjct: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINS-THARL 1558

Query: 558  TWETPVSGNGEIQNYKLYYMEKGTDKEQDVDV-SSHSYTINGLKKYTEYSFRVVAYNKHG 616
              +   +G   I    L Y  KGT   Q +   SS    +  L++ T Y  R+ A N  G
Sbjct: 1559 NLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618

Query: 617  PGVSTPDVA 625
             G  T   A
Sbjct: 1619 CGNETAQFA 1627



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/213 (25%), Positives = 89/213 (41%), Gaps = 14/213 (6%)

Query: 536  VQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSS--HS 593
            VQ+P   P L     S +SIT+TW    +G   I+ + L Y    +++ +DV +SS   S
Sbjct: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499

Query: 594  YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH 653
            + ++ LK  T Y  ++ A N  G G  +  +  +T    PS +         NS    ++
Sbjct: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559

Query: 654  WQPPAPATQNG--QITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
             Q       NG   IT   + YR   + +   + L + +     +  L   T Y  R+ A
Sbjct: 1560 LQ----GWNNGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFLTELREATWYELRMRA 1613

Query: 712  LTINGTGPATDWLSAETFESDLDETRVPEVPSS 744
                G G  T    A+    D D + +P + S+
Sbjct: 1614 CNSAGCGNET----AQFATLDYDGSTIPPIKSA 1642


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  243 bits (619), Expect = 1e-63
 Identities = 275/1056 (26%), Positives = 422/1056 (39%), Gaps = 111/1056 (10%)

Query: 56   LVEPVDTLSVRGSS-VILNCSAYSEPSPKIE--WKKDGTFLNL-VSDDRRQLL---PDGS 108
            ++ P +T  V G+S V L C A + P  K+   WKKDG  L+  +SD  R+L    P GS
Sbjct: 218  IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS 277

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGT-IISRTAKLIVAGLPRFTSQPEPSSVYAGN 167
                          D GYY+C A + S     + R A L V   P+F  +PE        
Sbjct: 278  --------------DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEME 323

Query: 168  NAI-LNCEVNADLVPFVRWEQNRQPLLLDD--RVIKLPSGMLVISNATEGDGGLYRCVVE 224
              + + C+      P + W ++   + ++   R  +   G L IS     D G+++C   
Sbjct: 324  KVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFAR 383

Query: 225  SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMK 284
            +      + EV+         I+  +  + P     + G  VVL C  SG P P I W K
Sbjct: 384  NA-----AGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITWQK 437

Query: 285  NEEALDTESSE--RLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPE 342
             E  L + S +  R   L  GSL IS     DAGTY C+A N     EA A+L V A+  
Sbjct: 438  GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTR 497

Query: 343  FLKQPTNIYAHESMDIVFECEVTGKPTPTVK--WVKNGDMVIPSDYFKIVKEHN--LQVL 398
              K P +    +       C VT  P  T++  W K+G  +    + +I  + N  L + 
Sbjct: 498  ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHIS 557

Query: 399  GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASL--VSTRFIK 456
                 D G Y C   +  GN    A L + +        LP AP   VA+L  V  R I 
Sbjct: 558  QTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ--------LPHAPEHPVATLSTVERRAIN 609

Query: 457  LTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQ 516
            LTW  P  D +   + Y +  ++       +  +  P    VT++ L+PA  Y FR+ A 
Sbjct: 610  LTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAV 668

Query: 517  NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKL 574
            N  G G+ S      + PE     P  N+ A   +  SI + W+ P     NG ++ Y +
Sbjct: 669  NDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII 728

Query: 575  YY----MEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 630
             Y    +  G   +   D   ++  +  L  +T Y   V AYN  G GV +  V   TL 
Sbjct: 729  RYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQ 788

Query: 631  DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGT 690
             VP+  P N+  E  NS +I   W  P+P   NG   GYK+   +  ++ +VT       
Sbjct: 789  GVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPN 848

Query: 691  QLSQL----IEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
                +    + GL + TEY   V   T  G GP +      T E       VP     L 
Sbjct: 849  FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED------VPGPVGHLS 902

Query: 747  VRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRY---YTIENLDPS 802
               ++ TS+ VSW  P  +N ++ GY I +   +    T    Y       Y +  L   
Sbjct: 903  FSEILDTSLKVSWQEPGEKNGILTGYRISWEEYN-RTNTRVTHYLPNVTLEYRVTGLTAL 961

Query: 803  SHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQA 862
            + Y I + A  + G+G                +V    I+   + VP   P  PP  +  
Sbjct: 962  TTYTIEVAAMTSKGQG----------------QVSASTIS---SGVPPELP-GPPTNLGI 1001

Query: 863  SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTK------YKNANATTLSYL 916
            S +   ++ + +     P +   T    + V  +  +    +        +      S  
Sbjct: 1002 SNIGPRSVTLQFR----PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSME 1057

Query: 917  VTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG-TTFELVPTSPPKDVTVVSKEGKPKTIIV 975
            V  L P T Y F +       +S  S  +    T +  P   P +V++  +     ++ +
Sbjct: 1058 VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL--RTASETSLWL 1115

Query: 976  NWQPPSE----ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRL--THQIQELTLDTPYY 1029
             W P  E     N +  GY I YS    ++ H   +  VV +R+   + I++L   T Y 
Sbjct: 1116 RWMPLPEMEYNGNPESVGYKIKYS---RSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYR 1172

Query: 1030 FKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQA 1065
             ++QA N+ G GP S+ V  RT ++  S    N  A
Sbjct: 1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSA 1208



 Score =  159 bits (402), Expect = 2e-38
 Identities = 164/623 (26%), Positives = 253/623 (40%), Gaps = 59/623 (9%)

Query: 396  QVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFI 455
            +V GL        +  A    G  Q  A  I     P   GP    P ++  S +  R +
Sbjct: 954  RVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP----PTNLGISNIGPRSV 1009

Query: 456  KLTWRTPASDPHGDNLTYSVFYTKEGIARERVE------NTSHPGEMQVTIQNLMPATVY 509
             L +R P  D    +++  +   + G+  E  E       ++ P    + + +L P T Y
Sbjct: 1010 TLQFR-PGYDGK-TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067

Query: 510  IFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP-NLRAYAASPTSITVTW----ETPVS 564
             FR+   N  G+   S P R + Q     P  AP N+    AS TS+ + W    E   +
Sbjct: 1068 SFRMRQVNIVGTSPPSQPSR-KIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYN 1126

Query: 565  GNGEIQNYKLYYMEKG----TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVS 620
            GN E   YK+ Y        T      D     YTI  L+++TEY  +V A+N  G G  
Sbjct: 1127 GNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPW 1186

Query: 621  TPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKS 680
            +  V  RT   VPS+ P N+S     S S+++ W     A +NG + GYK+ Y++    +
Sbjct: 1187 SQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDT 1246

Query: 681  DVTETLVSG-TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
                 LV G +  S  + GL +   Y  +V A T  G G  +        E  LD+   P
Sbjct: 1247 QPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPS---HPPILERTLDDVPGP 1303

Query: 740  EVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDY---KQRYYTI 796
             +   L      TS+ + W PP   N ++  Y I + + +  A T  V+      R YT 
Sbjct: 1304 PM-GILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTA 1362

Query: 797  ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
              L P S Y+  + A    G G       VT    D              P P   PM+ 
Sbjct: 1363 TGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRD-------------RPQPPSRPMVQ 1409

Query: 857  PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANAT--TLS 914
               V+A      ++ ++W     P    ++  RYYT++ +          +A+ +    S
Sbjct: 1410 QEDVRAR-----SVLLSWE----PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASS 1460

Query: 915  YLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG-TTFELVPTSPPKDVTVVSKEGKPKTI 973
            ++V  LKP T Y+F V  T     S +S  +   TT +  P   P  ++V        ++
Sbjct: 1461 FIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPH--TTTSV 1518

Query: 974  IVNWQPPSE--ANGKITGYIIYY 994
            ++ WQPP+E   NG + G+ I Y
Sbjct: 1519 LIRWQPPAEDKINGILLGFRIRY 1541



 Score =  152 bits (385), Expect = 2e-36
 Identities = 236/1077 (21%), Positives = 390/1077 (36%), Gaps = 147/1077 (13%)

Query: 59   PVDTLSVRGSSVILNCSAYSEPSPKIE--WKKDGTFLNLVSDDRRQLLPDGSLFISNVVH 116
            P D   ++G+   + C    +P   I   W+KDG  L   S  R +L  +GSL IS    
Sbjct: 502  PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWS 561

Query: 117  SKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAI-----L 171
                  D G Y C   V S G   SR+A L V  LP     P  +       AI      
Sbjct: 562  G-----DIGTYTC--RVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614

Query: 172  NCEVNADLVPFV-RWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYR-CVVESGGPP 229
              + N+ L+ ++    +N  P  +    +   +  + +          +R C V   G  
Sbjct: 615  PFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKG 674

Query: 230  KYSDEVELKVLPD------PEVI-------SDLVFLKQPSPLVRVIG--QDVVLPCVASG 274
            ++S + E   LP+      P+ +         ++   QP P     G  +  ++    +G
Sbjct: 675  QFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAG 734

Query: 275  LPTPTIKWMKNEEALDTESS--ERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQ 332
            LP       KN    D  +   E L++     +E++       G Y              
Sbjct: 735  LPVGY--QFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS----------SKV 782

Query: 333  AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIP------SDY 386
             E T+Q  P     P N++A  +                +  +  G  +I        + 
Sbjct: 783  TEWTLQGVPTV--PPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV 840

Query: 387  FKIVKEHNLQ-------VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP 439
              +    N Q       V GL K  E F   +     G+       ++  H       +P
Sbjct: 841  TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED-----VP 895

Query: 440  SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
                 +  S +    +K++W+ P  + +G    Y + + +      RV +      ++  
Sbjct: 896  GPVGHLSFSEILDTSLKVSWQEPG-EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYR 954

Query: 500  IQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW 559
            +  L   T Y   V A    G G+ SA       P  +LPGP  NL      P S+T+ +
Sbjct: 955  VTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPP-ELPGPPTNLGISNIGPRSVTLQF 1013

Query: 560  ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSH---------SYTINGLKKYTEYSFRVV 610
                 G   I  + L   + G   E +  +  H         S  +  L  +T YSFR+ 
Sbjct: 1014 RPGYDGKTSISRW-LVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMR 1072

Query: 611  AYNKHGPGV-STPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNG--QIT 667
              N  G    S P   ++TL   P  AP N+SL   +  S+ + W P      NG  +  
Sbjct: 1073 QVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESV 1132

Query: 668  GYKIRYRKASRKSDVTETLVSG-TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSA 726
            GYKI+Y ++         +V    +    IE L+  TEY  +V A    G+GP +  +  
Sbjct: 1133 GYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVG 1192

Query: 727  ETFESDLDETRVPEVPSS--LHVRPLVT---SIVVSWT--PPENQNIVVRGYAIGYGIGS 779
             T ES         VPSS   +V  L T   S++V W+  P  ++N +V GY + Y    
Sbjct: 1193 RTRES---------VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMY---- 1239

Query: 780  PHAQTIKVDYKQRYYTIENLDPSSH----------YVITLKAFNNVGEGIPLYESAVTRP 829
               +    D + R++ +E     S           Y + + AF  +G+G P +   + R 
Sbjct: 1240 ---KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT 1296

Query: 830  HTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSR 889
              D               VP P     P+G+    +   ++R+ W   + P    I  + 
Sbjct: 1297 LDD---------------VPGP-----PMGILFPEVRTTSVRLIWQPPAAPNG--IILAY 1334

Query: 890  YYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG-- 947
              T R  T        +    +   Y  TGLKP ++Y F +     +    W   A    
Sbjct: 1335 QITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITA---QTRKGWGEAAEALV 1391

Query: 948  -TTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWV 1006
             TT +     PP    V  ++ + ++++++W+P S+    +  Y I      +     W 
Sbjct: 1392 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR---WA 1448

Query: 1007 IEP--VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMP 1061
            +    V  N  +  +  L   T Y F+++A N  G    SE  +  T    + D+ P
Sbjct: 1449 LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP 1505



 Score =  144 bits (364), Expect = 5e-34
 Identities = 179/656 (27%), Positives = 273/656 (41%), Gaps = 60/656 (9%)

Query: 437  PLPSAPRDVVASLVSTRFIKLTWRT-PASDPHG--DNLTYSVFYTK-EGIARERVENTSH 492
            P   AP +V     S   + L W   P  + +G  +++ Y + Y++ +G  +        
Sbjct: 1095 PPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQD 1154

Query: 493  PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
              E   TI++L   T Y  +V A N  GSG  S  +   T+  V   GP  N+ A A + 
Sbjct: 1155 RVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPT-NVSALATTS 1213

Query: 553  TSITVTW-ETPVSG-NGEIQNYKLYYMEKGTDKEQDVDV----SSHSYTINGLKKYTEYS 606
            +S+ V W E P +  NG +  YK+ Y EK +D +    +    SS S  + GL KY  Y 
Sbjct: 1214 SSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYE 1273

Query: 607  FRVVAYNKHGPGV-STPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQ 665
             +V+A+ + G G  S P +  RTL DVP      L  EVR + S+ + WQPPA    NG 
Sbjct: 1274 VQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT-SVRLIWQPPA--APNGI 1330

Query: 666  ITGYKIRYR-KASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWL 724
            I  Y+I +R   +  +  T  +++ +       GL   + Y FR+ A T  G G A + L
Sbjct: 1331 ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390

Query: 725  SAETFESDLDETRVPEVPSSLHVRPLVT-------SIVVSWTPPENQNIVVRGYAIG--- 774
               T + D      P+ PS    RP+V        S+++SW P  +    VR Y I    
Sbjct: 1391 VVTTEKRDR-----PQPPS----RPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRE 1441

Query: 775  YGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYES-AVTRPHTDT 833
               G     +  V +    + ++ L P + Y   +KA N++G+     ES ++T      
Sbjct: 1442 LPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501

Query: 834  SEVDLFVINAPYTPVPDPTPMMPPVGVQAS-ILSHDTIRITWADNSLPKHQKITDSRYYT 892
             E    +   P+T         PP   + + IL    IR         +       R +T
Sbjct: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY--------RELLYEGLRGFT 1553

Query: 893  VRWKTNIPAN-----TKYKNANATTLS---YLVTGLKPNTLYEFSVMVTKGRRSSTWSMT 944
            +R   N  A      + Y   N +  S   Y +  L  +  YE  + V         S  
Sbjct: 1554 LRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPP 1613

Query: 945  AHGTTFELVPTSPPKDVTVVSKEGKPKTII-VNWQPP--SEANGKITGYIIYYSTDVNAE 1001
                  E VPT+ P++V V    G   T + V W+PP     NG I GY IY+       
Sbjct: 1614 QEVFVGEAVPTAAPRNVVV---HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGN 1670

Query: 1002 IHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSS 1057
            + + V    +      +++ LT  T Y   + A N+ G GP S   Q +T +A  S
Sbjct: 1671 LTERVKTLFLAENSV-KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS 1725



 Score =  130 bits (328), Expect = 7e-30
 Identities = 157/668 (23%), Positives = 268/668 (40%), Gaps = 100/668 (14%)

Query: 434  TTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYT-KEGIARERVENTSH 492
            T   +P  P  ++   V T  ++L W+ PA+ P+G  L Y + +      A         
Sbjct: 1296 TLDDVPGPPMGILFPEVRTTSVRLIWQPPAA-PNGIILAYQITHRLNTTTANTATVEVLA 1354

Query: 493  PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPA-PNLRAYAAS 551
            P   Q T   L P +VY+FR+ AQ + G GE++  L V T+   +   P+ P ++     
Sbjct: 1355 PSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVR 1414

Query: 552  PTSITVTWETPVSGNGEIQNYKLYYMEKGTDK----EQDVDVSSHSYTINGLKKYTEYSF 607
              S+ ++WE    G   ++ Y +   E  + +       V  ++ S+ ++ LK +T Y F
Sbjct: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474

Query: 608  RVVAYNKHGPG-VSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQI 666
            RV A N  G    S    ++ TL   P  AP  LS+    + S++I WQPPA    NG +
Sbjct: 1475 RVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGIL 1534

Query: 667  TGYKIRYRK---------------------ASRKSDVTETLVSGTQLSQL-IEGLDRGTE 704
             G++IRYR+                     A   S  +   +S   L+Q  ++ L++   
Sbjct: 1535 LGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRR 1594

Query: 705  YNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPP--E 762
            Y  R++     G GP++     E F  +   T  P   + +      T + V+W PP  +
Sbjct: 1595 YEIRMSVYNAVGEGPSSP--PQEVFVGEAVPTAAPR--NVVVHGATATQLDVTWEPPPLD 1650

Query: 763  NQNIVVRGYAIGYGIGSPHAQTIKVD---YKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
            +QN  ++GY I +        T +V      +    ++NL   + Y++++ AFN  G+G 
Sbjct: 1651 SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG- 1709

Query: 820  PLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSL 879
                S  T+  T  +        AP            P  V+ S L+  ++ ++W     
Sbjct: 1710 --PRSTPTQGQTQQA--------AP----------SAPSSVKFSELTTTSVNVSWEAPQF 1749

Query: 880  PK-----HQKITD--------SRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLY 926
            P      ++ + +        S+  TV  K N P   K K+            L     Y
Sbjct: 1750 PNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD------------LAEGVTY 1797

Query: 927  EFSVMVTKGRRSSTWS----MTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE 982
             F +      R+ T++    + A+ TT        P  V ++ +      I ++W     
Sbjct: 1798 RFRI------RAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYS--SAIAIHWSSGDP 1849

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIE--PVVGNRLTHQIQELTLDTPYYFKIQARNSKGM 1040
              G IT Y+I  +   +  + D +I+  P   +  T  +  L     Y F++ A N  G 
Sbjct: 1850 GKGPITRYVI-EARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGF 1908

Query: 1041 GPMSEAVQ 1048
            G  S   Q
Sbjct: 1909 GTPSSPSQ 1916



 Score =  114 bits (285), Expect = 7e-25
 Identities = 158/648 (24%), Positives = 251/648 (38%), Gaps = 75/648 (11%)

Query: 440  SAPRDVVASLVSTRFIKLTW-RTPASDPHGDNLTYSVFYT-KEGIARERVENTSHPGEMQ 497
            S P +V A   ++  + + W   P +D +G  L Y V Y  K+   + R           
Sbjct: 1201 SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS 1260

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
              +  L    +Y  +V+A  + G G  S P  +E   +  +PGP   +       TS+ +
Sbjct: 1261 AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLD-DVPGPPMGILFPEVRTTSVRL 1319

Query: 558  TWETPVSGNGEIQNYKLYY-MEKGTDKEQDVDV---SSHSYTINGLKKYTEYSFRVVAYN 613
             W+ P + NG I  Y++ + +   T     V+V   S+  YT  GLK  + Y FR+ A  
Sbjct: 1320 IWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQT 1379

Query: 614  KHGPGVSTPDVAVRTLS---DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
            + G G +   + V T       P + P     +VR ++S+++ W+P +       +  Y 
Sbjct: 1380 RKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVR-ARSVLLSWEPGSDGLS--PVRYYT 1436

Query: 671  IRYRKA-SRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETF 729
            I+ R+  S +  +    VS    S +++ L   T Y FRV A     T    D   +E  
Sbjct: 1437 IQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKA-----TNDIGDSEFSEES 1491

Query: 730  ESDLDETRVP-EVPSSLHVRP-LVTSIVVSWTPPENQNI--VVRGYAIGY---------- 775
            ES       P E P+ L V P   TS+++ W PP    I  ++ G+ I Y          
Sbjct: 1492 ESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG 1551

Query: 776  ----GIGSPHAQTIKVD--YKQR--------YYTIENLDPSSHYVITLKAFNNVGEGIPL 821
                GI +P A   ++   Y  R         Y ++NL+    Y I +  +N VGEG   
Sbjct: 1552 FTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG--- 1608

Query: 822  YESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPK 881
                   P +   EV           V +  P   P  V     +   + +TW    L  
Sbjct: 1609 -------PSSPPQEVF----------VGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDS 1651

Query: 882  HQKITDSRYYTVRWKTNIPANT-KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 940
             Q      Y    W+      T + K       S  +  L   T Y  SV          
Sbjct: 1652 -QNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710

Query: 941  WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGY-IIYYSTDVN 999
             S    G T +  P++P    +V   E    ++ V+W+ P   NG + GY ++Y      
Sbjct: 1711 RSTPTQGQTQQAAPSAPS---SVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPV 1767

Query: 1000 AEIHDWVIEPVVGNR-LTHQIQELTLDTPYYFKIQARNSKGMGPMSEA 1046
              +   V   V GN  L  ++++L     Y F+I+A+     GP  EA
Sbjct: 1768 DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGPEIEA 1814



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 50/198 (25%), Positives = 85/198 (42%), Gaps = 13/198 (6%)

Query: 439  PSAPRDVVASLVSTRFIKLTWRTPASDP---HGDNLTYSVFYTKEGIARERVENTSHPGE 495
            PSAP  V  S ++T  + ++W  P        G  L Y      +G+++    +      
Sbjct: 1724 PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSP 1783

Query: 496  MQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
            + + +++L     Y FR+ A+      E  A   V T P    PGP P +       ++I
Sbjct: 1784 LWLKVKDLAEGVTYRFRIRAKTFTYGPEIEA--NVTTGPGEGAPGP-PGVPIIVRYSSAI 1840

Query: 556  TVTWETPVSGNGEIQNYKLYYMEKGTD------KEQDVDVSSHSYTINGLKKYTEYSFRV 609
             + W +   G G I  Y +              K+   +VSS++++++ LK    Y FRV
Sbjct: 1841 AIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRV 1900

Query: 610  VAYNKHGPGV-STPDVAV 626
            +A N +G G  S+P  +V
Sbjct: 1901 IAVNDYGFGTPSSPSQSV 1918



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 46/172 (26%), Positives = 68/172 (39%), Gaps = 9/172 (5%)

Query: 259 VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
           V + G  +VL C+A G      KW+ N   L   S E   +       I+ +    AG Y
Sbjct: 37  VHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYM-------ITSLDRTHAGFY 89

Query: 319 FCIADNG-NETIEAQAELTVQAQPEFLK-QPTNIYAHESMDIVFECEVTGKPTPTVKWVK 376
            CI  N     ++ Q E+ V     F + +     +H    ++    +   P P V W +
Sbjct: 90  RCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFR 149

Query: 377 NGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
           +G  + PS    I  E+ L +L  V  D G Y   A ND       +Q I L
Sbjct: 150 DGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITL 201


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score =  241 bits (614), Expect = 5e-63
 Identities = 174/596 (29%), Positives = 275/596 (46%), Gaps = 29/596 (4%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F VEP D ++V G  ++L+C     P  +I W+K+G  + L       LL +GSL I + 
Sbjct: 44  FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNG--VELPESTHSTLLANGSLMIRHF 101

Query: 115 VHSKHNKP-DEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNC 173
                  P DEG Y+CVA     G ++SR A++  A +  F   P+ +    G  A   C
Sbjct: 102 RLEPGGSPSDEGDYECVAQ-NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160

Query: 174 EVNADLVPFVRWEQNRQPLLLD-DRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYS 232
           +++    P + WE+NR P+  D +R   LP G+L I+     DGG++ CV  +    + S
Sbjct: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRIS 220

Query: 233 DEVELKVLPDPE-VISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDT 291
               L V         +   L  P  L   + Q  VL CVA+G P P + W +    LD 
Sbjct: 221 HGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR----LDG 276

Query: 292 E--SSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE--AQAELTVQAQPEFLKQP 347
                E + +L  G+L ISDVT   +G Y C A+     +   AQ  L VQA  EF++ P
Sbjct: 277 RPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP 336

Query: 348 TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN-LQVLGLVKSDEG 406
            +I        +F C+  G+P P V W+KNG ++ P  + ++   ++ L + G+   DE 
Sbjct: 337 QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEA 396

Query: 407 FYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466
            YQC+AEN  G++QA A+L +L         LP  PR+V A  VS+  ++++W  P ++ 
Sbjct: 397 IYQCVAENSAGSSQASARLTVL-----WAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANT 451

Query: 467 HGDNLTYSVFYTKEGIARE-RVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESS 525
             + + Y +   K     E   +        Q  + +L P+T Y F + A    G+  +S
Sbjct: 452 K-EIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS 510

Query: 526 APLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQ 585
            P    T  E   P   P L       +S+ + WE           +KL+Y         
Sbjct: 511 VPTLASTLGEAPAP---PPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567

Query: 586 D---VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPD-VAVRTLSDVPSAAP 637
               +  +  SY ++ L     Y  +++AYN+HG G +T   V++R  S+  + +P
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSP 623



 Score =  179 bits (455), Expect = 1e-44
 Identities = 161/588 (27%), Positives = 243/588 (41%), Gaps = 45/588 (7%)

Query: 154 FTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN--- 210
           F  +P       G   +L+C V       + W +N   L        L +G L+I +   
Sbjct: 44  FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103

Query: 211 ---ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVV 267
               +  D G Y CV ++    ++   V  K       +SD  F   P   V   G    
Sbjct: 104 EPGGSPSDEGDYECVAQN----RFGLVVSRKARIQAATMSD--FHVHPQATVGEEGGVAR 157

Query: 268 LPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN-GN 326
             C   GLP P I W KN   +DT++ ER  LL  G L+I+ +  +D G + C+A N  +
Sbjct: 158 FQCQIHGLPKPLITWEKNRVPIDTDN-ERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS 216

Query: 327 ETIEAQAELTVQA-------QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
             I   A LTV         +P  L  P N+        V EC  TG P P V W +   
Sbjct: 217 IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDG 276

Query: 380 MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP 439
             I  +  +++   NL +  +     G Y C A       +  AQ  ++  APA     P
Sbjct: 277 RPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP 336

Query: 440 SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
            +    ++    T  +          PH   L         G  R +  N++      +T
Sbjct: 337 QS----ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNST------LT 386

Query: 500 IQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW 559
           I  + P    I++ +A+N  GS ++SA L V       LPGP  N+RA + S T + V+W
Sbjct: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEG--LPGPPRNVRAVSVSSTEVRVSW 444

Query: 560 ETPVSGNGEIQNYKLYYMEKGTDK-----EQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
             P++   EI  Y L ++ K  D      ++ V  S+  + ++ L+  T YSF + AY  
Sbjct: 445 SEPLANTKEIIGYVL-HIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTP 503

Query: 615 HGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQP-PAPATQNGQITGYKIRY 673
            G   ++      TL + P  AP  LS+ V  S S+ + W+P P  A   G   G+K+ Y
Sbjct: 504 RGASSASVPTLASTLGEAP--APPPLSVRVLGSSSLQLLWEPWPRLAQHEG---GFKLFY 558

Query: 674 RKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPAT 721
           R AS+ S     L+ GT  S  +  LD    Y  ++ A   +G G AT
Sbjct: 559 RPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606



 Score =  115 bits (289), Expect = 2e-25
 Identities = 148/602 (24%), Positives = 236/602 (39%), Gaps = 68/602 (11%)

Query: 247 SDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLE 306
           ++L F  +PS  V V GQ +VL C   G P   I W KN   ++   S    LLA GSL 
Sbjct: 40  AELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKN--GVELPESTHSTLLANGSLM 97

Query: 307 ISDV------TEDDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359
           I         +  D G Y C+A N     +  +A +      +F   P      E     
Sbjct: 98  IRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157

Query: 360 FECEVTGKPTPTVKWVKNGDMV-IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418
           F+C++ G P P + W KN   +   ++ + ++ +  LQ+ GL   D G + C+A N    
Sbjct: 158 FQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNI--- 214

Query: 419 AQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPA-------SDPHGDNL 471
               A + I   A  T     S      A LV    + LT    A        +P     
Sbjct: 215 ----ASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVS 270

Query: 472 TYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSG-ESSAPLRV 530
              +     G+   +V  T +     VT+Q+   + VY   V A N+ G+    +A  R+
Sbjct: 271 WSRLDGRPIGVEGIQVLGTGNLIISDVTVQH---SGVY---VCAANRPGTRVRRTAQGRL 324

Query: 531 ETQPEVQLPGPAPNLRAYAASPTSIT----------VTWETPVSGNGEIQNYKLYYMEKG 580
             Q   +      ++   A +    T          VTW      NG++          G
Sbjct: 325 VVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTW----LKNGQV---------LG 371

Query: 581 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL 640
                 +  ++ + TI+G+    E  ++ VA N  G   ++  + V     +P   P+N+
Sbjct: 372 PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP-GPPRNV 430

Query: 641 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVT-ETLVSGTQLSQLIEGL 699
                +S  + + W  P   T+  +I GY +  RKA+   ++  +  VS +    L+  L
Sbjct: 431 RAVSVSSTEVRVSWSEPLANTK--EIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDL 488

Query: 700 DRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSW 758
           +  T Y+F + A T  G   A    S  T  S L E      P  L VR L  +S+ + W
Sbjct: 489 EPSTAYSFYIKAYTPRGASSA----SVPTLASTLGEA---PAPPPLSVRVLGSSSLQLLW 541

Query: 759 TPPENQNIVVRGYAIGYGIGSPHAQT--IKVDYKQRYYTIENLDPSSHYVITLKAFNNVG 816
            P         G+ + Y   S  + T  I +      Y +  LDP++ Y + L A+N  G
Sbjct: 542 EPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601

Query: 817 EG 818
           +G
Sbjct: 602 DG 603



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 132/543 (24%), Positives = 208/543 (38%), Gaps = 65/543 (11%)

Query: 45  ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL 104
           A I+  T   F V P  T+   G      C  +  P P I W+K+   ++   ++R  LL
Sbjct: 131 ARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID-TDNERYTLL 189

Query: 105 PDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTI-ISRTAKLIVAGL-------PRFTS 156
           P G L I+ +        D G + CVA+  ++ +I IS  A+L V+G        P    
Sbjct: 190 PKGVLQITGL-----RAEDGGIFHCVAS--NIASIRISHGARLTVSGSGSGAYKEPAILV 242

Query: 157 QPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG 216
            PE  ++     A+L C    +  P V W +     +  + +  L +G L+IS+ T    
Sbjct: 243 GPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHS 302

Query: 217 GLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
           G+Y C     G           V+  P       F++ P  + R  G   +  C A G P
Sbjct: 303 GVYVCAANRPGTRVRRTAQGRLVVQAP-----AEFVQHPQSISRPAGTTAMFTCQAQGEP 357

Query: 277 TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
            P + W+KN + L      RL      +L IS +  +D   Y C+A+N   + +A A LT
Sbjct: 358 PPHVTWLKNGQVLGPGGHVRL-KNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416

Query: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVT---GKPTPTVKWVKNGDMVIPS-------DY 386
           V         P N+ A      V   EV     +P    K +    + I         +Y
Sbjct: 417 VLWAEGLPGPPRNVRAVS----VSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEY 472

Query: 387 FKIVKEHNLQ--VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRD 444
            + V +   Q  V  L  S    +   A    G + A    +      +T G  P AP  
Sbjct: 473 QEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTL-----ASTLGEAP-APPP 526

Query: 445 VVASLVSTRFIKLTWRT-PASDPHGDNLTYSVFYTKEGIARERVENTSHPGEM------- 496
           +   ++ +  ++L W   P    H     + +FY            TS  G +       
Sbjct: 527 LSVRVLGSSSLQLLWEPWPRLAQHEGG--FKLFY-------RPASKTSFTGPILLPGTVS 577

Query: 497 QVTIQNLMPATVYIFRVMAQNKHGSGESS---APLRVETQPEVQLPGPAPNLRAYAASPT 553
              +  L P  VY  +++A N+HG G ++     LR  ++    L  P    +  AA+ T
Sbjct: 578 SYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASE-RTALSPPCDCRKEEAANQT 636

Query: 554 SIT 556
           S T
Sbjct: 637 STT 639



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 44/187 (23%), Positives = 81/187 (43%), Gaps = 10/187 (5%)

Query: 856  PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA-NATTLS 914
            PP  V+A  +S   +R++W++  L   ++I    Y     K   P   +Y+ A + +T  
Sbjct: 426  PPRNVRAVSVSSTEVRVSWSE-PLANTKEIIG--YVLHIRKAADPPELEYQEAVSKSTFQ 482

Query: 915  YLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTII 974
            +LV+ L+P+T Y F +     R +S+ S+    +T    P  PP  V V+       ++ 
Sbjct: 483  HLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGS----SSLQ 538

Query: 975  VNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQA 1034
            + W+P         G+ ++Y           ++ P  G   ++ + +L     Y  K+ A
Sbjct: 539  LLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP--GTVSSYNLSQLDPTAVYEVKLLA 596

Query: 1035 RNSKGMG 1041
             N  G G
Sbjct: 597  YNQHGDG 603


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  237 bits (604), Expect = 7e-62
 Identities = 237/871 (27%), Positives = 359/871 (41%), Gaps = 91/871 (10%)

Query: 4   ERGARRLLS-TPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFT-PFYFLVEPVD 61
           ER  RR+ +  P   +  ++  G +  G          Q  G+ +R    P   +  P D
Sbjct: 6   ERVTRRMWTWAPGLLMMTVVFWGHQGNG----------QGQGSRLRQEDFPPRIVEHPSD 55

Query: 62  TLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVVHSK 118
            +  +G    LNC A   P+P IEW KDG  +    DD    R LLP GSLF   +VH +
Sbjct: 56  VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGR 115

Query: 119 HNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCEV-N 176
            +KPDEG Y CVA    LG  +SR A L VA L   F   P    V AG  AIL C+   
Sbjct: 116 RSKPDEGSYVCVAR-NYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPR 174

Query: 177 ADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVE 236
               P + W++++  +   +  I +  G L+ISN  + D G+Y CV  +    + SD  E
Sbjct: 175 GHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE 234

Query: 237 LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSER 296
           L V   P       FL++P   V +  + V   C   G P PT++W K++  L      R
Sbjct: 235 LTVFERP------TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG---R 285

Query: 297 LVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESM 356
             +    +L I      D GTY CIA+N    +EA A LTV+A P+F+ +P +    +  
Sbjct: 286 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGR 345

Query: 357 DIVFECEVTGKPTPTVKWVKNGDMVI--------PSDYFKIVKEHNLQVLGLVKSDEGFY 408
            + F CE  G P P V W K G   +        P+    +    +L +  + +SD G+Y
Sbjct: 346 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405

Query: 409 QCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPASDPH 467
            C A    G+  A AQL + +       P +   P +   ++  T  +K           
Sbjct: 406 ICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK-------CKAT 458

Query: 468 GDNLTYSVFYTKEGI---ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGES 524
           GD L   + + KEG     R+        G +Q  I+NL  +    +  +A +  G    
Sbjct: 459 GDPLPV-ISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTCVATSSSGETSW 515

Query: 525 SAPLRVETQPEV--------QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYY 576
           SA L V               LPGP    +    +  S+T++W+    G      Y +  
Sbjct: 516 SAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEA 575

Query: 577 MEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTP-DVAVRTLSDV 632
             +            V +  YT+ GL+  T Y F V A N  G    +P    VRT    
Sbjct: 576 FSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDIS 635

Query: 633 PSAAPQNLSLEVRNSKSIMIHWQPPAPAT------------QNGQITGYKIRYRKAS--R 678
           P A   +     +    +++    P   T            Q   I GY++ YR+ S  +
Sbjct: 636 PPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQ 695

Query: 679 KSDVTETLVS--GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDET 736
            +   + L +   T+ S ++  L +G  Y  +V        G  ++  +  T E   +  
Sbjct: 696 ATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE---EAP 752

Query: 737 RVPEVPSSLHVRPL----VTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTIK--VD 788
             P  P S+ V  +     TSI VSW   PP++QN +++ Y I + +G+     I   VD
Sbjct: 753 SAP--PQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINKTVD 809

Query: 789 YKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
              R   I  L P   Y + + A  + G G+
Sbjct: 810 AAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 840



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 81/334 (24%), Positives = 129/334 (38%), Gaps = 27/334 (8%)

Query: 725  SAETFESDLDETRVPEVPSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHA- 782
            S  T   + D + +P  PS   V  +   S+ +SW P     +    Y I     S    
Sbjct: 524  SGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNS 583

Query: 783  -QTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVI 841
             QT+    K   YT+  L P++ Y+  ++A N  G   P   S   R    T ++     
Sbjct: 584  WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVR----TQDISPPAQ 639

Query: 842  NAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPA 901
               +  V      +        +L+  T+++TW  +  P+  +     Y   R  + + A
Sbjct: 640  GVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMY---RQTSGLQA 696

Query: 902  NTKYKNANA---TTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPP 958
             + ++N +A   T  S ++  LK    YE  V           S +    T E  P++PP
Sbjct: 697  TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP 756

Query: 959  KDVTVVSKEGKPKT-IIVNWQ--PPSEANGKITGYIIY-YSTDVNAEIH---DWVIEPVV 1011
            + VTV++      T I V+W   PP   NG I  Y I+    +    I+   D  I  V+
Sbjct: 757  QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI 816

Query: 1012 GNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSE 1045
               L   IQ       Y  ++ A  S G+G  SE
Sbjct: 817  IGGLFPGIQ-------YRVEVAASTSAGVGVKSE 843



 Score = 32.7 bits (73), Expect = 2.6
 Identities = 55/249 (22%), Positives = 91/249 (36%), Gaps = 26/249 (10%)

Query: 856  PPVGVQASILSHDTIRITW---ADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912
            PP   Q + ++ +++ ++W      +LP    I ++   +V       AN      +  T
Sbjct: 540  PPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVAN------HVKT 593

Query: 913  LSYLVTGLKPNTLYEFSVMVTKGRRSSTWS-MTAHGTTFELVPTSPPKDVTVVSKE---- 967
              Y V GL+PNT+Y F V     +  S  S M+    T ++ P +   D   V KE    
Sbjct: 594  TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDV 653

Query: 968  ---------GKPKTIIVNWQPPSEANGKITGY-IIYYSTDVNAEIHDWV-IEPVVGNRLT 1016
                       P T+ V W    +    I GY ++Y  T        W  ++  V    +
Sbjct: 654  LVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 712

Query: 1017 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP 1076
              +  L     Y  K++   ++  G  SE+   RT +   S    +      G   S   
Sbjct: 713  AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 772

Query: 1077 DLGSDYKPP 1085
             +  D  PP
Sbjct: 773  SVSWDPPPP 781


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  236 bits (603), Expect = 9e-62
 Identities = 226/814 (27%), Positives = 339/814 (41%), Gaps = 79/814 (9%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW KDG  +    DD    R LLP GSLF   +V
Sbjct: 37  PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + +KPDEG Y CVA    LG  +SR A L VA L   F   P    V AG  AIL C+
Sbjct: 97  HGRRSKPDEGSYVCVAR-NYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155

Query: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W++++  +   +  I +  G L+ISN  + D G+Y CV  +    + SD
Sbjct: 156 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL V   P       FL++P   V +  + V   C   G P PT++W K++  L    
Sbjct: 216 PAELTVFERP------TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG- 268

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
             R  +    +L I      D GTY CIA+N    +EA A LTV+A P+F+ +P +    
Sbjct: 269 --RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326

Query: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVI--------PSDYFKIVKEHNLQVLGLVKSDE 405
           +   + F CE  G P P V W K G   +        P+    +    +L +  + +SD 
Sbjct: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 386

Query: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
           G+Y C A    G+  A AQL + +       P +   P +   ++  T  +K        
Sbjct: 387 GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK-------C 439

Query: 465 DPHGDNLTYSVFYTKEGI---ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGS 521
              GD L   + + KEG     R+        G +Q  I+NL  +    +  +A +  G 
Sbjct: 440 KATGDPLPV-ISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTCVATSSSGE 496

Query: 522 GESSAPLRVETQPEV--------QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK 573
              SA L V               LPGP    +    +  S+T++W+    G      Y 
Sbjct: 497 TSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYI 556

Query: 574 LYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTP-DVAVRTL 629
           +    +            V +  YT+ GL+  T Y F V A N  G    +P    VRT 
Sbjct: 557 IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQ 616

Query: 630 SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPAT------------QNGQITGYKIRYRKAS 677
              P A   +     +    +++    P   T            Q   I GY++ YR+ S
Sbjct: 617 DISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTS 676

Query: 678 --RKSDVTETLVS--GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDL 733
             + +   + L +   T+ S ++  L +G  Y  +V        G  ++  +  T E   
Sbjct: 677 GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE--- 733

Query: 734 DETRVPEVPSSLHVRPL----VTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTIK- 786
           +    P  P S+ V  +     TSI VSW   PP++QN +++ Y I + +G+     I  
Sbjct: 734 EAPSAP--PQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINK 790

Query: 787 -VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
            VD   R   I  L P   Y + + A  + G G+
Sbjct: 791 TVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 824



 Score =  153 bits (386), Expect = 1e-36
 Identities = 207/840 (24%), Positives = 333/840 (39%), Gaps = 117/840 (13%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G    LNC+      P + W ++ + +  D        + LPSG L
Sbjct: 31  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G Y CV  +  G     +  +E+ +L D        F + P+ +V
Sbjct: 91  FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------FRQNPTDVV 143

Query: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
              G+  +L C    G P PTI W K++  +D    E  + + GG L IS+  + DAG Y
Sbjct: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRID--DKEERISIRGGKLMISNTRKSDAGMY 201

Query: 319 FCIADN-GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N   E     AELTV  +P FL++P N    E   + F C+V G P PTV+W K 
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW-KK 260

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   + I  ++ L++   + +DEG Y CIAEN VG  +A A L +   AP     
Sbjct: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPP---Q 315

Query: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
               PRD +  +   R +     T        N   +VF+ KEG      +N   P + Q
Sbjct: 316 FVVRPRDQI--VAQGRTVTFPCETKG------NPQPAVFWQKEG-----SQNLLFPNQPQ 362

Query: 498 -------------VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLP 539
                        +TI N+  +    +   A    GS  + A L V     +  P + L 
Sbjct: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422

Query: 540 GPAPN---------LRAYAASPTSITVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDV 589
           GPA           L+  A       ++W +   +  G  ++ +    E+GT + +++ +
Sbjct: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPG--RDPRATIQEQGTLQIKNLRI 480

Query: 590 S-SHSYTINGLKKYTEYSF-RVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNS 647
           S + +YT        E S+  V+   + G  +S        LSD+P   P    +     
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKN----YDLSDLP-GPPSKPQVTDVTK 535

Query: 648 KSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNF 707
            S+ + WQP  P T        +   +  S         V  T  +  + GL   T Y F
Sbjct: 536 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYT--VRGLRPNTIYLF 593

Query: 708 RVAALTING---TGPATDWLSAETFE---SDLDETRVPEVPSSLHVR---PLV---TSIV 755
            V A+   G     P +D +  +        +D  +V +    + VR   P+V   T++ 
Sbjct: 594 MVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQ 653

Query: 756 VSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNV 815
           V+WT  + Q   ++GY + Y       QT  +     +  ++   P+    + +    N+
Sbjct: 654 VTWT-VDRQPQFIQGYRVMY------RQTSGLQATSSWQNLDAKVPTERSAVLV----NL 702

Query: 816 GEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASIL---SHDTIRI 872
            +G+  YE  V RP+   +E       +      +  P  PP  V    +   +  +I +
Sbjct: 703 KKGV-TYEIKV-RPY--FNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISV 758

Query: 873 TWADNSLPKHQK--ITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSV 930
           +W D   P HQ   I + + + +  +T    N   K  +A   S ++ GL P   Y   V
Sbjct: 759 SW-DPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIGGLFPGIQYRVEV 814



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 80/308 (25%), Positives = 126/308 (40%), Gaps = 28/308 (9%)

Query: 42  SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
           S  A +  F    FL  P++ + +   +V   C    +P P + WKKD   L      R 
Sbjct: 214 SDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRY 270

Query: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
            +  D +L I   + +     DEG Y C+A  E+    +  +A L V   P+F  +P   
Sbjct: 271 DIKDDYTLRIKKTMST-----DEGTYMCIA--ENRVGKMEASATLTVRAPPQFVVRPRDQ 323

Query: 162 SVYAGNNAILNCEVNADLVPFVRWEQN--------RQPLLLDDRVIKLPSGMLVISNATE 213
            V  G      CE   +  P V W++          QP   + R    P+G L I+N   
Sbjct: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR 383

Query: 214 GDGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDL---VFLKQPSPLVRVIGQDVVLP 269
            D G Y C  +   G      ++E+      +V++D    + L+ P+     +    +L 
Sbjct: 384 SDAGYYICQALTVAGSILAKAQLEV-----TDVLTDRPPPIILQGPANQTLAVDGTALLK 438

Query: 270 CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
           C A+G P P I W+K E         R  +   G+L+I ++   D GTY C+A + +   
Sbjct: 439 CKATGDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497

Query: 330 EAQAELTV 337
              A L V
Sbjct: 498 SWSAVLDV 505



 Score = 32.7 bits (73), Expect = 2.6
 Identities = 55/249 (22%), Positives = 91/249 (36%), Gaps = 26/249 (10%)

Query: 856  PPVGVQASILSHDTIRITW---ADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912
            PP   Q + ++ +++ ++W      +LP    I ++   +V       AN      +  T
Sbjct: 524  PPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVAN------HVKT 577

Query: 913  LSYLVTGLKPNTLYEFSVMVTKGRRSSTWS-MTAHGTTFELVPTSPPKDVTVVSKE---- 967
              Y V GL+PNT+Y F V     +  S  S M+    T ++ P +   D   V KE    
Sbjct: 578  TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDV 637

Query: 968  ---------GKPKTIIVNWQPPSEANGKITGY-IIYYSTDVNAEIHDWV-IEPVVGNRLT 1016
                       P T+ V W    +    I GY ++Y  T        W  ++  V    +
Sbjct: 638  LVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696

Query: 1017 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP 1076
              +  L     Y  K++   ++  G  SE+   RT +   S    +      G   S   
Sbjct: 697  AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756

Query: 1077 DLGSDYKPP 1085
             +  D  PP
Sbjct: 757  SVSWDPPPP 765


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  230 bits (586), Expect = 9e-60
 Identities = 278/1048 (26%), Positives = 422/1048 (40%), Gaps = 96/1048 (9%)

Query: 56   LVEPVDTLSVRGSS-VILNCSAYSEPSP--KIEWKKDGTFLN--LVSDDRRQLLPDGSLF 110
            +V P +   V GSS   L C A + P     + WK++G  +   L S  RR       L 
Sbjct: 296  VVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRR-------LT 348

Query: 111  ISNVVHSKHNKPDEGYYQCVATVESLGTIISR-TAKLIVAGLPRFTSQPEPS-SVYAGNN 168
            ISN   +     D G Y C A +       +R TA L +   P FT++PE   S      
Sbjct: 349  ISNPTSA-----DTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403

Query: 169  AILNCEVNADLVPFVRWEQNRQPL--LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226
              + C+     +P ++W ++   +  L + R   L SG L I      D G+++C   + 
Sbjct: 404  VDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNE 463

Query: 227  GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNE 286
            G      E++     D   I+  VF ++P       G   +L C  SG P P I W +  
Sbjct: 464  G-----GEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKREN 517

Query: 287  EALDTESSE--RLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFL 344
              L + S    R +LL  G L+I+ V   DAG Y C A N   ++ A A LTV  +   +
Sbjct: 518  HILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIV 577

Query: 345  KQPTNIYAHESMDIVFECEVTGKPTPTVK--WVKNGDMVIPSDYFKIV--KEHNLQVLGL 400
              P +    +       C  T  P  +++  W K+   + PS   +IV  K+ +L +   
Sbjct: 578  HPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQT 637

Query: 401  VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRF--IKLT 458
               D G Y C   ++ GN    A+L ++E        LP +P++++ S  S+    + L+
Sbjct: 638  WSGDIGDYSCEIVSEGGNDSRMARLEVIE--------LPHSPQNLLVSPNSSHSHAVVLS 689

Query: 459  WRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ-VTIQNLMPATVYIFRVMAQN 517
            W  P        + Y +    E  +  +V  ++   EM  VT+  L PA  Y FRV A N
Sbjct: 690  WVRPFDG--NSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVN 747

Query: 518  KHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP--VSGNGEIQNYKLY 575
            + G G+ SA       PE     P  N+ A   +  SI V W+ P     NG ++ Y L 
Sbjct: 748  EVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILR 807

Query: 576  YMEKGTDKE-QDVDVSSHSYT---INGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSD 631
            Y   G   E Q  +++S       +  L  +T+Y  +V AYN  G GV +  V   TL  
Sbjct: 808  YRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQG 867

Query: 632  VPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVS--- 688
            VP+A PQN+  E  NS +I   W PP     NG   GYK+    A     VT   ++   
Sbjct: 868  VPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDF 927

Query: 689  -GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHV 747
             G      I  L + T Y   V   T  G GP +      T      E +   V      
Sbjct: 928  HGVHHGH-ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWT-----QEDKPGAVGHLSFT 981

Query: 748  RPLVTSIVVSWTPPENQNIVVRGYAIGYGI--GSPHAQTIKVDYKQRYYTIENLDPSSHY 805
              L TS+ VSW  P  +N ++ GY I + +   +    T  ++     Y I+ L   + Y
Sbjct: 982  EILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041

Query: 806  VITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASIL 865
             I + A   VG G+    +  +    D       ++ +  +P        P    + SI 
Sbjct: 1042 TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSI- 1100

Query: 866  SHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL-VTGLKPNT 924
                    W      +   I D   +           T Y+  N      L +  L P T
Sbjct: 1101 ------SRWIVEG--QVGAIGDEEEWV----------TLYEEENEPDAQMLEIPNLTPYT 1142

Query: 925  LYEFSVMVTKGRRSSTWSMTAHG-TTFELVPTSPPKDVTVVSKEGKPKTIIVNW--QPPS 981
             Y F +        S +S ++    T +  P   P  VTV  +     ++ + W   P S
Sbjct: 1143 HYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV--RTASETSLRLRWVPLPDS 1200

Query: 982  EANG--KITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQ--IQELTLDTPYYFKIQARNS 1037
            + NG  +  GY I Y     +++    +  VV +RL  +  I+EL     Y  ++QA N+
Sbjct: 1201 QYNGNPESVGYRIKY---WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNA 1257

Query: 1038 KGMGPMSEAVQFRTPKADSSDKMPNDQA 1065
             G GP SE V+ RT ++  S    N  A
Sbjct: 1258 VGAGPWSEVVRGRTRESVPSAAPENVSA 1285



 Score =  215 bits (548), Expect = 2e-55
 Identities = 260/1035 (25%), Positives = 420/1035 (40%), Gaps = 128/1035 (12%)

Query: 33   AARSGSA--PQSPGASIRTFTPFYFLVEPVDTLSVRGSSVI-LNCSAYSEPSPKIEWKKD 89
            AA  GSA  P    A +    P YF  EP   +S      + + C A   P P ++W KD
Sbjct: 364  AALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKD 423

Query: 90   GTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVA 149
               ++ + + R ++L  G L I      K    D G +QC A+ E  G I + T   +  
Sbjct: 424  AISISRLQNPRYKVLASGGLRIQ-----KLRPEDSGIFQCFASNEG-GEIQTHTYLDVTN 477

Query: 150  GLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDD----RVIKLPSGM 205
              P FT +P  ++V  G  AIL CEV+    P + W++    L        R + L SG 
Sbjct: 478  IAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGG 537

Query: 206  LVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQD 265
            L I+     D G Y C   +        E  L       V +    +  P   V + G  
Sbjct: 538  LQIAPVFIQDAGNYTCYAAN-------TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTT 590

Query: 266  VVLPCVASGLPTPTIK--WMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFC--I 321
              L C A+  P  +++  W K+  AL   S+ R+V+   GSL IS     D G Y C  +
Sbjct: 591  ATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIV 650

Query: 322  ADNGNETIEAQAELTV--QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
            ++ GN++  A+ E+     +    L  P + ++H  +               + WV+  D
Sbjct: 651  SEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVV---------------LSWVRPFD 695

Query: 380  MVIPSDYFKIVKEHN-----------------LQVLGLVKSDEGFYQCIAENDVGNAQAG 422
               P  Y+ +    N                 + V GL  +    ++  A N+VG  Q  
Sbjct: 696  GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS 755

Query: 423  AQ---LIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLT-YSVFYT 478
            A+   L++ E  P+      + P+++VAS  + + I + W+ P    H   L  Y + Y 
Sbjct: 756  AETSRLMLPEEPPS------APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYR 809

Query: 479  KEGIARE-RVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQ 537
              G+  E +  N + P      + +L+  T Y  +V A N  G G  S  +   T   V 
Sbjct: 810  LAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVP 869

Query: 538  LPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKLYYMEKGTDKEQDVDVSS---- 591
               P  N++  A + T+I   W  P     NG  Q YKL  +    D  + V V +    
Sbjct: 870  T-APPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL--LAWPADAPEAVTVVTIAPD 926

Query: 592  ----HSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNS 647
                H   I  LKK+T Y   V+ +   G G  +    V T  D P A       E+ ++
Sbjct: 927  FHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDT 986

Query: 648  KSIMIHWQPPAPATQNGQITGYKIRYRKASRK-SDVTETLVSGTQLSQLIEGLDRGTEYN 706
             S+ + WQ P    +NG ITGY+I +    R  S +T TL S T     I+GL   T Y 
Sbjct: 987  -SLKVSWQEPLE--KNGIITGYQISWEVYGRNDSRLTHTLNSTTH-EYKIQGLSSLTTYT 1042

Query: 707  FRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQN 765
              VAA+T  GTG  T    +     DL     P  PS+L +  +   S  + + P  +  
Sbjct: 1043 IDVAAVTAVGTGLVTSSTISSGVPPDL-----PGAPSNLVISNISPRSATLQFRPGYDGK 1097

Query: 766  IVVRGYAIGYGIGSPHAQTIKVDYKQ-------RYYTIENLDPSSHYVITLKAFNNVGEG 818
              +  + +   +G+   +   V   +       +   I NL P +HY   +K  N VG  
Sbjct: 1098 TSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPS 1157

Query: 819  IPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNS 878
                      P++ +S V +  + AP        P + P  V     S  ++R+ W    
Sbjct: 1158 ----------PYSPSSRV-IQTLQAP--------PDVAPTSVTVRTASETSLRLRWVPLP 1198

Query: 879  LPKHQKITDSRYYTVR-WKTNIPANTKYK-NANATTLSYLVTGLKPNTLYEFSVMVTKGR 936
              ++    +S  Y ++ W++++ ++   +  ++     + +  L+    YE  +      
Sbjct: 1199 DSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAV 1258

Query: 937  RSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKT-IIVNWQ--PPSEANGKITGY-II 992
             +  WS    G T E VP++ P++   VS E    T I++ W   P  + NG I GY I+
Sbjct: 1259 GAGPWSEVVRGRTRESVPSAAPEN---VSAEAVSSTQILLTWTSVPEQDQNGLILGYKIL 1315

Query: 993  YYSTDVNAEIHDWVI 1007
            + + D++ E    ++
Sbjct: 1316 FRAKDLDPEPRSHIV 1330



 Score =  174 bits (441), Expect = 6e-43
 Identities = 173/587 (29%), Positives = 252/587 (42%), Gaps = 67/587 (11%)

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEG----IARER-----VE 488
            LP AP ++V S +S R   L +R     P  D  T    +  EG    I  E       E
Sbjct: 1069 LPGAPSNLVISNISPRSATLQFR-----PGYDGKTSISRWIVEGQVGAIGDEEEWVTLYE 1123

Query: 489  NTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP-NLRA 547
              + P    + I NL P T Y FR+   N  G    S   RV  Q     P  AP ++  
Sbjct: 1124 EENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRV-IQTLQAPPDVAPTSVTV 1182

Query: 548  YAASPTSITVTW----ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSS----HSYTINGL 599
              AS TS+ + W    ++  +GN E   Y++ Y            V S      +TI  L
Sbjct: 1183 RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEEL 1242

Query: 600  KKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAP 659
            +++ EY  ++ A+N  G G  +  V  RT   VPSAAP+N+S E  +S  I++ W     
Sbjct: 1243 EEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPE 1302

Query: 660  ATQNGQITGYKIRYRKASRKSDVTETLVSGTQL-SQLIEGLDRGTEYNFRVAALTINGTG 718
              QNG I GYKI +R      +    +V G    S L+ GL +   Y  +V A T  G G
Sbjct: 1303 QDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNG 1362

Query: 719  PATDWLSAETFESDLDETRVPEVPSSLHVRPLV--TSIVVSWTPPENQNIVVRGYAIGYG 776
              +  L  E  + D      P  P  L V P V  TS+ + W PPE  N ++ GY I Y 
Sbjct: 1363 VPSTPLILERTKDD-----APGPPVRL-VFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416

Query: 777  I--GSPHA-QTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDT 833
            +   SPH   T++V    R +T  +L P S Y+  L A    G G PL  + +T   T+ 
Sbjct: 1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVIT---TEK 1473

Query: 834  SEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTV 893
             E           P P    ++P   V A      ++R+ W    +P     +  RY+T+
Sbjct: 1474 RE----------RPAPPRELLVPQAEVTAR-----SLRLQW----VPGSDGASPIRYFTM 1514

Query: 894  RWKTNIPA---NTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSM-TAHGTT 949
            + +  +P     T   + +    + +V  L+P T Y+  +  T     S +S  T   TT
Sbjct: 1515 QVR-ELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573

Query: 950  FELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE--ANGKITGYIIYY 994
             + VP  PP  V+         ++++ WQPP +   NG + GY IYY
Sbjct: 1574 LQDVPGEPPGSVSATPH--TTSSVLIQWQPPRDESLNGLLQGYRIYY 1618



 Score =  162 bits (410), Expect = 2e-39
 Identities = 244/1037 (23%), Positives = 397/1037 (38%), Gaps = 157/1037 (15%)

Query: 54   YFLVEP-VDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFIS 112
            YF  EP +  + + G+ ++L C A      + +W +D + L   S + + ++P       
Sbjct: 105  YFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIP------- 157

Query: 113  NVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILN 172
                    K D G+Y+CV     +G ++ R +++ VA +  F    +  +V  G  AILN
Sbjct: 158  -----SLQKLDAGFYRCVVR-NRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILN 211

Query: 173  -CEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLY--RCVVESGGPP 229
               + +   P V W +    ++  +R+       LVI   T  D G Y  + V E  G  
Sbjct: 212  LLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGEN 271

Query: 230  KYSDEVELKVLPD---PEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTP--TIKWMK 284
            K S  + L +  D   PE ++  + +   +  V     +  L C+AS  P    ++ W +
Sbjct: 272  KTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331

Query: 285  NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFC---IADNGNETIEAQAELTVQAQP 341
            N   + +          G  L IS+ T  D G Y C   +  +  E   A A L +   P
Sbjct: 332  NGVRITSGLHS-----FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPP 386

Query: 342  EFLKQP-TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYFKIVKEHNLQVL 398
             F  +P + I A     +   C+  G P PT++W K+   +  + +  +K++    L++ 
Sbjct: 387  YFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQ 446

Query: 399  GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPA-TTGPLPSAPRDVVASLVSTRFI-- 455
             L   D G +QC A N+ G  Q    L +   AP  T  P+ +   D + +++       
Sbjct: 447  KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506

Query: 456  ---KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFR 512
                +TW+         ++    F   E             G +Q+    +  A  Y   
Sbjct: 507  PKPAITWKRENHILASGSVRIPRFMLLES------------GGLQIAPVFIQDAGNY--T 552

Query: 513  VMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNY 572
              A N  GS  +SA L V  +  +  P     +     +      T +  VS     +  
Sbjct: 553  CYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKD 612

Query: 573  KLYYMEKGTDK---EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
             +      T +   E+D  +   S T +G     +YS  +V+      G +   +A   +
Sbjct: 613  NVALTPSSTSRIVVEKDGSLLI-SQTWSG--DIGDYSCEIVS-----EGGNDSRMARLEV 664

Query: 630  SDVPSAAPQNLSLEVRNSKS--IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLV 687
             ++P  +PQNL +   +S S  +++ W  P     N  I  Y +   + +    V  + V
Sbjct: 665  IELPH-SPQNLLVSPNSSHSHAVVLSWVRPFDG--NSPILYYIVELSENNSPWKVHLSNV 721

Query: 688  SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHV 747
                    + GL     Y FRV A+   G G      SAET         +PE P S   
Sbjct: 722  GPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQ----YSAET-----SRLMLPEEPPSAPP 772

Query: 748  RPLVT------SIVVSWTPP--ENQNIVVRGYAIGY---GIGSPHAQTIKVDYKQRYYTI 796
            + +V       SI+V W PP     N V+RGY + Y   G+   + Q      +  Y  +
Sbjct: 773  KNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLV 832

Query: 797  ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
             +L   + Y I + A+N  G G+ ++  AVT                 YT    PT   P
Sbjct: 833  TDLIIWTQYEIQVAAYN--GAGLGVFSRAVTE----------------YTLQGVPT--AP 872

Query: 857  PVGVQASILSHDTIRITWADNSLPKHQKIT--DSRYYTVRWKTNIPANTKYKNANATTLS 914
            P  VQ   ++  TI+  W   + P  Q I   +  Y  + W  + P         A T+ 
Sbjct: 873  PQNVQTEAVNSTTIQFLW---NPPPQQFINGINQGYKLLAWPADAP--------EAVTVV 921

Query: 915  YL-----------VTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTV 963
             +           +T LK  T Y  SV+        T       +T +LV T   K   V
Sbjct: 922  TIAPDFHGVHHGHITNLKKFTAYFTSVL------CFTTPGDGPPSTPQLVWTQEDKPGAV 975

Query: 964  ---VSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ 1020
                  E    ++ V+WQ P E NG ITGY I            W +     +RLTH + 
Sbjct: 976  GHLSFTEILDTSLKVSWQEPLEKNGIITGYQI-----------SWEVYGRNDSRLTHTLN 1024

Query: 1021 ELTLDTPYYFKIQARNS 1037
                 T + +KIQ  +S
Sbjct: 1025 ----STTHEYKIQGLSS 1037



 Score =  119 bits (299), Expect = 2e-26
 Identities = 155/665 (23%), Positives = 263/665 (39%), Gaps = 75/665 (11%)

Query: 440  SAPRDVVASLVSTRFIKLTWRT-PASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ- 497
            +AP +V A  VS+  I LTW + P  D +G  L Y + +  + +  E   +       Q 
Sbjct: 1278 AAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS 1337

Query: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
              +  L    +Y  +V+A  + G+G  S PL +E   +   PGP   L       TS+ +
Sbjct: 1338 ALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKD-DAPGPPVRLVFPEVRLTSVRI 1396

Query: 558  TWETPVSGNGEIQNYKLYYMEKGTDKEQ----DVDVSSHSYTINGLKKYTEYSFRVVAYN 613
             W+ P   NG I  Y++ Y    +        +V  +   +T   L   + Y FR+ A  
Sbjct: 1397 VWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKT 1456

Query: 614  KHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRN--SKSIMIHWQPPAPATQNGQITGYKI 671
            + G G       + T      A P+ L +      ++S+ + W P +       I  + +
Sbjct: 1457 RQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGAS--PIRYFTM 1514

Query: 672  RYRKASRKSDVT-ETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
            + R+  R    T  + +S    + +++ L   T Y  R+ A    G    +    A T  
Sbjct: 1515 QVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTL 1574

Query: 731  SDLDETRVPEVPSSLHVRPLVTS-IVVSWTPPENQNI--VVRGYAIGY-------GIGSP 780
             D+      E P S+   P  TS +++ W PP ++++  +++GY I Y       G G+ 
Sbjct: 1575 QDVPG----EPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGT- 1629

Query: 781  HAQTIK--------VDYKQRYYTIENLDPSS-----------HYVITLKAFNNVGEGIPL 821
             A+T+K        +  +  + T+ +   S+            Y + + A+N +GE    
Sbjct: 1630 EAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGE---- 1685

Query: 822  YESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPK 881
              S  + P      V++FV  A         P M P  VQ + L+   + +TW D   P+
Sbjct: 1686 --SPASAP------VEVFVGEA--------APAMAPQNVQVTPLTASQLEVTW-DPPPPE 1728

Query: 882  HQKITDSRYYTVRWKTNIPANT-KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST 940
             Q      Y    W+ +    T K K          +  L  +T Y  S+          
Sbjct: 1729 SQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGP 1788

Query: 941  WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA 1000
             S    G T +  P +P     +   E    T+ V+W  P+ ANG + GY + Y      
Sbjct: 1789 KSDPQQGRTHQAAPGAPS---FLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPV 1845

Query: 1001 E-IHDWVIEPVVGN-RLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSD 1058
            + +   V   V GN +   ++++LT    Y+F++QAR     GP  +A       A+ S 
Sbjct: 1846 QGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTIT-YGPELQA-NITAGPAEGSP 1903

Query: 1059 KMPND 1063
              P D
Sbjct: 1904 GSPRD 1908



 Score =  111 bits (277), Expect = 6e-24
 Identities = 106/415 (25%), Positives = 181/415 (43%), Gaps = 52/415 (12%)

Query: 439  PSAPRDVVA--SLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKE---GIARERVENTSHP 493
            P+ PR+++   + V+ R ++L W  P SD     + Y     +E   G  +    + SH 
Sbjct: 1477 PAPPRELLVPQAEVTARSLRLQW-VPGSDG-ASPIRYFTMQVRELPRGEWQTYSSSISHE 1534

Query: 494  GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP-NLRAYAASP 552
                V +  L P T Y  R+ A N  G  + S+     T  +  +PG  P ++ A   + 
Sbjct: 1535 ATACV-VDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQ-DVPGEPPGSVSATPHTT 1592

Query: 553  TSITVTWETP--VSGNGEIQNYKLYYME------KGTDKEQ---------DVDVSSHSYT 595
            +S+ + W+ P   S NG +Q Y++YY E       GT+ +          ++   S   T
Sbjct: 1593 SSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKT 1652

Query: 596  ING-----------LKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
            +N            LKKY  Y   + AYN  G   ++  V V      P+ APQN+ +  
Sbjct: 1653 VNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTP 1712

Query: 645  RNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL-IEGLDRGT 703
              +  + + W PP P +QNG I GYKI Y +A  +++  +  V       + ++ L   T
Sbjct: 1713 LTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHT 1772

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLV-TSIVVSWTPPE 762
            +Y   ++A    G GP +D     T ++       P  PS L    +  T++ VSW  P 
Sbjct: 1773 KYLVSISAFNAAGDGPKSDPQQGRTHQA------APGAPSFLAFSEITSTTLNVSWGEPA 1826

Query: 763  NQNIVVRGYAIGYGIGSP---HAQTIKVDYK---QRYYTIENLDPSSHYVITLKA 811
              N +++GY + Y   +P    ++ + V+ +   QR+  + +L     Y   ++A
Sbjct: 1827 AANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA 1881



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 49/207 (23%), Positives = 87/207 (42%), Gaps = 17/207 (8%)

Query: 439  PSAPRDVVASLVSTRFIKLTWRTPASDP---HGDNLTYSVFYTKEGIARERVENTSHPGE 495
            P AP  +  S +++  + ++W  PA+      G  + Y      +G+++          +
Sbjct: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQ 1861

Query: 496  MQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
              + +++L     Y FRV A+      E  A   +   P    PG +P       S + +
Sbjct: 1862 RWLKVRDLTKGVTYFFRVQARTITYGPELQA--NITAGPAEGSPG-SPRDVLVTKSASEL 1918

Query: 556  TVTWETPVSGNGEIQNYKLYYMEKGTDKE------QDVDVSSHSYTIN--GLKKYTEYSF 607
            T+ W    SG+     Y +    + +D+       +D+  S+ SYT++   L++   Y F
Sbjct: 1919 TLQWTEGHSGDTPTTGYVIE--ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976

Query: 608  RVVAYNKHGPG-VSTPDVAVRTLSDVP 633
            RVVA N+ G G  S P  AV    + P
Sbjct: 1977 RVVAVNEAGYGEPSNPSTAVSAQVEAP 2003


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  229 bits (583), Expect = 2e-59
 Identities = 196/789 (24%), Positives = 340/789 (43%), Gaps = 72/789 (9%)

Query: 63  LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKP 122
           ++++G  ++L C A   P+P I+W                L P G +    V +  HNK 
Sbjct: 248 VALQGQPLVLECIAEGFPTPTIKW----------------LRPSGPMPADRVTYQNHNKT 291

Query: 123 ---------DEGYYQCVATVESLGTIISRTAKLI-VAGLPRFTSQPEPSSVYAGNNAILN 172
                    D+G Y+C+A   SLG+  +R A  + V   P +  +P+      G  A L+
Sbjct: 292 LQLLKVGEEDDGEYRCLAE-NSLGS--ARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 348

Query: 173 CEVNADLVPFVRWEQNRQPL--LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPP 229
           C+V     P V W  N  P+  L  D+  ++  G L++SN    D  + +C   +  G  
Sbjct: 349 CQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLL 408

Query: 230 KYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL 289
             +  + +  LP   + +D          + V G    L C A G P P+++W+ +E+  
Sbjct: 409 LANAYIYVVQLPAKILTAD------NQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGT 461

Query: 290 DTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTN 349
                ER    A G+L I D+  +D G YFC+A N    +   A L V+   +  + P +
Sbjct: 462 TVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRS 521

Query: 350 IYAHESMDIVFECEVTGKPT--PTVKWVKNG-DMVIPSDYFK-IVKEHNLQVLGLVKSDE 405
               +   + F C+ +  P+  P++ W  +G D+    D  K  +++  L +  L  SD+
Sbjct: 522 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 581

Query: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASD 465
           G Y C+A  ++   ++ AQL+++     + GP+P      +  L  ++ ++++W +PA D
Sbjct: 582 GNYSCVASTELDVVESRAQLLVV----GSPGPVPRLVLSDLHLLTQSQ-VRVSW-SPAED 635

Query: 466 PHGDNLTYSVFYTKEGIARERVENTSH-PGEMQVTIQNLMPATVYIFRVMAQNKHGSGES 524
            +     Y + +  + +A E+  +    PG    T   L P   Y FRV A NK+G GE 
Sbjct: 636 HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEP 695

Query: 525 SAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP--VSGNGEIQNYKLYYMEKGT- 581
           S        PE        +++      T++ +TW+    +  N     Y++ +  +GT 
Sbjct: 696 SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 755

Query: 582 DKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLS 641
              Q+  VS     ++    +  Y  +V A N  G G         +  D P A P+   
Sbjct: 756 GPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEG 815

Query: 642 LEVRNSKSIMIHWQPPAPATQNGQITGYKIRY-------RKASRKSDVTETLVSGTQLSQ 694
           +E+ NS ++++ W+P   A   G + GY + Y       + + R       +V     S 
Sbjct: 816 IEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSV 875

Query: 695 LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR-PLVTS 753
           ++ GL   + Y+  V A    G+GPA+++    TF +      VP  P +LH+     TS
Sbjct: 876 ILSGLRPYSSYHLEVQAFNGRGSGPASEF----TFST---PEGVPGHPEALHLECQSNTS 928

Query: 754 IVVSWTPPENQNIVVRGYAIGYGI----GSPHAQTIKVDYKQRYYTIENLDPSSHYVITL 809
           +++ W PP + N V+ GY + Y      G         D + R + + +L P   Y   L
Sbjct: 929 LLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQL 988

Query: 810 KAFNNVGEG 818
           +A    G G
Sbjct: 989 QATTKEGPG 997



 Score =  145 bits (365), Expect = 4e-34
 Identities = 231/1037 (22%), Positives = 395/1037 (38%), Gaps = 121/1037 (11%)

Query: 51   TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL--PDGS 108
            +P   +V P D +S       L C A  +P  +  W +DG       +    +   P   
Sbjct: 36   SPRRLVVFPTDDIS-------LKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGN 167
             F     +S   +  +G Y+C A+   LGT +S   +L+  G P++  +  +P  V  G 
Sbjct: 89   SFTITGNNSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 147

Query: 168  NAILNCEVNADLVPFVRWEQNRQPLLL--DDRVIKLPSGMLVISNATEGDGGL-YRCVVE 224
            + +L C       P   +  N + L +  D+RV    +G L  +N    D    Y C   
Sbjct: 148  SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 207

Query: 225  SGGPPKY--SDEVELKVLPDPEVISDLVFLKQP----SPLVRVIGQDVVLPCVASGLPTP 278
              G       + ++L+V     +I     L  P    S LV + GQ +VL C+A G PTP
Sbjct: 208  FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTP 267

Query: 279  TIKWMKNEEALDTESSERLVLL-AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTV 337
            TIKW++    +    ++R+       +L++  V E+D G Y C+A+N   +      +TV
Sbjct: 268  TIKWLRPSGPM---PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 324

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYFKIVKEHNL 395
            +A P +L +P +           +C+V G+P P V W  NG  V  +  D    ++   L
Sbjct: 325  EAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGAL 384

Query: 396  QVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFI 455
             +  +  SD    QC A N  G   A A + +++  PA    L +  +  +A   ST ++
Sbjct: 385  ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ-LPAKI--LTADNQTYMAVQGSTAYL 441

Query: 456  KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMA 515
                        G  +    +  ++G    + E         + I++L       +  +A
Sbjct: 442  -------LCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLA 494

Query: 516  QNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT-----------SITVTWETPVS 564
             N   +    A L+V+   ++   GP   +    +  T             ++TW     
Sbjct: 495  ANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGR 553

Query: 565  GNGEIQNYKLYYMEKGTDKEQDVDVS---SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
               E+ +   Y++E G      +D S   ++S   +      E   +++     GP    
Sbjct: 554  DLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGP---- 609

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
              V    LSD          L +     + + W P      N  I  Y I +       +
Sbjct: 610  --VPRLVLSD----------LHLLTQSQVRVSWSP--AEDHNAPIEKYDIEFEDKEMAPE 655

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
               +L  V G Q S  ++ L     Y FRV A+   G G  +             E    
Sbjct: 656  KWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 714

Query: 740  EVPSSLHVRPLVTSIVVSWTPPE--NQNIVVRGYAIGY---GIGSPHAQTIKVDYKQRYY 794
            +V    +     T++V++W P    + N     Y + +   G   P  + I  D    + 
Sbjct: 715  DVKGEGNE---TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSD---PFL 768

Query: 795  TIENLDPSSHYVITLKAFNNVGEG----IPLYESAVTRPHTDTSEVDLFVINAPYTPVPD 850
             + N      Y I ++A N+ G+G    + +  S    P        + ++N+    V  
Sbjct: 769  VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV-- 826

Query: 851  PTPMMPPVGVQASILSH-DTIRIT-WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA 908
                  PV + A +  H     +T W + S  KH K    + + V     +PAN      
Sbjct: 827  ---KWRPVDL-AQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV-----VPAN------ 871

Query: 909  NATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEG 968
               T S +++GL+P + Y   V    GR S   S     T     P   P     +  E 
Sbjct: 872  ---TTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLEC 923

Query: 969  KPKT-IIVNWQPPSEANGKITGYIIYY---STDVNAEIHDWVIEPVVGNRLTHQIQELTL 1024
            +  T +++ WQPP   NG +TGY++ Y         ++   + +P +    TH + +L+ 
Sbjct: 924  QSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPEL---RTHNLTDLSP 980

Query: 1025 DTPYYFKIQARNSKGMG 1041
               Y F++QA   +G G
Sbjct: 981  HLRYRFQLQATTKEGPG 997



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 79/344 (22%), Positives = 130/344 (37%), Gaps = 78/344 (22%)

Query: 741  VPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIG-----------YGIGSPHAQTIKVDY 789
            V S LH+    + + VSW+P E+ N  +  Y I            Y +G       KV  
Sbjct: 614  VLSDLHLLTQ-SQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLG-------KVPG 665

Query: 790  KQRYYTIENLDPSSHYVITLKAFNNVGEG--IPLYESAVTRPHTDTSEVDLFVINAPYTP 847
             Q   T++ L P  HY   + A N  G G   P+ E+ VT                    
Sbjct: 666  NQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-------------------- 704

Query: 848  VPDPTPMMPPVGVQASILSHDTIRITWA-----DNSLPKHQKITDSRYYTVRWKTNIPAN 902
             P+  P   PV V+        + ITW      D + P+ Q       Y V+W+   P  
Sbjct: 705  -PEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWR---PQG 753

Query: 903  TK--YKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPK- 959
            T+  ++    +    +V+       YE  V     +          G + E  P + P+ 
Sbjct: 754  TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPEL 813

Query: 960  -DVTVVSKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIH-------DWVIEP 1009
              + +++       ++V W+P   ++  G + GY + Y  + +   H       D V+ P
Sbjct: 814  EGIEILNSSA----VLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVP 869

Query: 1010 VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
               N  +  +  L   + Y+ ++QA N +G GP SE   F TP+
Sbjct: 870  A--NTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPE 910



 Score = 38.1 bits (87), Expect = 0.063
 Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 9/97 (9%)

Query: 345 KQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSD-----YFKIVKEHNLQVLG 399
           + P  +    + DI  +CE +GKP    +W ++G    P +      ++     +  + G
Sbjct: 35  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 94

Query: 400 ----LVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
                 +  +G Y+C A N +G A +    ++ E AP
Sbjct: 95  NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP 131



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 37/158 (23%), Positives = 62/158 (39%), Gaps = 18/158 (11%)

Query: 240 LPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVL 299
           L +P VI++    + P  LV     D+ L C ASG P    +W +  + +  +  E L +
Sbjct: 26  LMEPPVITE----QSPRRLVVFPTDDISLKCEASGKPEVQFRWTR--DGVHFKPKEELGV 79

Query: 300 LA-----GGSLEI----SDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQPEFLKQPTN 349
                   GS  I    S+  +   G Y C A N   T +  +  L  +  P++ K+   
Sbjct: 80  TVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVK 139

Query: 350 -IYAHESMDIVFECEVTGKPTP-TVKWVKNGDMVIPSD 385
            +   E   +V  C       P  + W+ +  + I  D
Sbjct: 140 PVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQD 177


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
            sapiens]
          Length = 1253

 Score =  229 bits (583), Expect = 2e-59
 Identities = 196/789 (24%), Positives = 340/789 (43%), Gaps = 72/789 (9%)

Query: 63   LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKP 122
            ++++G  ++L C A   P+P I+W                L P G +    V +  HNK 
Sbjct: 253  VALQGQPLVLECIAEGFPTPTIKW----------------LRPSGPMPADRVTYQNHNKT 296

Query: 123  ---------DEGYYQCVATVESLGTIISRTAKLI-VAGLPRFTSQPEPSSVYAGNNAILN 172
                     D+G Y+C+A   SLG+  +R A  + V   P +  +P+      G  A L+
Sbjct: 297  LQLLKVGEEDDGEYRCLAE-NSLGS--ARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 353

Query: 173  CEVNADLVPFVRWEQNRQPL--LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPP 229
            C+V     P V W  N  P+  L  D+  ++  G L++SN    D  + +C   +  G  
Sbjct: 354  CQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLL 413

Query: 230  KYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL 289
              +  + +  LP   + +D          + V G    L C A G P P+++W+ +E+  
Sbjct: 414  LANAYIYVVQLPAKILTAD------NQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGT 466

Query: 290  DTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTN 349
                 ER    A G+L I D+  +D G YFC+A N    +   A L V+   +  + P +
Sbjct: 467  TVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRS 526

Query: 350  IYAHESMDIVFECEVTGKPT--PTVKWVKNG-DMVIPSDYFK-IVKEHNLQVLGLVKSDE 405
                +   + F C+ +  P+  P++ W  +G D+    D  K  +++  L +  L  SD+
Sbjct: 527  TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586

Query: 406  GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASD 465
            G Y C+A  ++   ++ AQL+++     + GP+P      +  L  ++ ++++W +PA D
Sbjct: 587  GNYSCVASTELDVVESRAQLLVV----GSPGPVPRLVLSDLHLLTQSQ-VRVSW-SPAED 640

Query: 466  PHGDNLTYSVFYTKEGIARERVENTSH-PGEMQVTIQNLMPATVYIFRVMAQNKHGSGES 524
             +     Y + +  + +A E+  +    PG    T   L P   Y FRV A NK+G GE 
Sbjct: 641  HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEP 700

Query: 525  SAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP--VSGNGEIQNYKLYYMEKGT- 581
            S        PE        +++      T++ +TW+    +  N     Y++ +  +GT 
Sbjct: 701  SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 760

Query: 582  DKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLS 641
               Q+  VS     ++    +  Y  +V A N  G G         +  D P A P+   
Sbjct: 761  GPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEG 820

Query: 642  LEVRNSKSIMIHWQPPAPATQNGQITGYKIRY-------RKASRKSDVTETLVSGTQLSQ 694
            +E+ NS ++++ W+P   A   G + GY + Y       + + R       +V     S 
Sbjct: 821  IEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSV 880

Query: 695  LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR-PLVTS 753
            ++ GL   + Y+  V A    G+GPA+++    TF +      VP  P +LH+     TS
Sbjct: 881  ILSGLRPYSSYHLEVQAFNGRGSGPASEF----TFST---PEGVPGHPEALHLECQSNTS 933

Query: 754  IVVSWTPPENQNIVVRGYAIGYGI----GSPHAQTIKVDYKQRYYTIENLDPSSHYVITL 809
            +++ W PP + N V+ GY + Y      G         D + R + + +L P   Y   L
Sbjct: 934  LLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQL 993

Query: 810  KAFNNVGEG 818
            +A    G G
Sbjct: 994  QATTKEGPG 1002



 Score =  145 bits (365), Expect = 4e-34
 Identities = 231/1037 (22%), Positives = 395/1037 (38%), Gaps = 121/1037 (11%)

Query: 51   TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL--PDGS 108
            +P   +V P D +S       L C A  +P  +  W +DG       +    +   P   
Sbjct: 41   SPRRLVVFPTDDIS-------LKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGN 167
             F     +S   +  +G Y+C A+   LGT +S   +L+  G P++  +  +P  V  G 
Sbjct: 94   SFTITGNNSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152

Query: 168  NAILNCEVNADLVPFVRWEQNRQPLLL--DDRVIKLPSGMLVISNATEGDGGL-YRCVVE 224
            + +L C       P   +  N + L +  D+RV    +G L  +N    D    Y C   
Sbjct: 153  SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212

Query: 225  SGGPPKY--SDEVELKVLPDPEVISDLVFLKQP----SPLVRVIGQDVVLPCVASGLPTP 278
              G       + ++L+V     +I     L  P    S LV + GQ +VL C+A G PTP
Sbjct: 213  FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTP 272

Query: 279  TIKWMKNEEALDTESSERLVLL-AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTV 337
            TIKW++    +    ++R+       +L++  V E+D G Y C+A+N   +      +TV
Sbjct: 273  TIKWLRPSGPM---PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYFKIVKEHNL 395
            +A P +L +P +           +C+V G+P P V W  NG  V  +  D    ++   L
Sbjct: 330  EAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGAL 389

Query: 396  QVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFI 455
             +  +  SD    QC A N  G   A A + +++  PA    L +  +  +A   ST ++
Sbjct: 390  ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ-LPAKI--LTADNQTYMAVQGSTAYL 446

Query: 456  KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMA 515
                        G  +    +  ++G    + E         + I++L       +  +A
Sbjct: 447  -------LCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLA 499

Query: 516  QNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT-----------SITVTWETPVS 564
             N   +    A L+V+   ++   GP   +    +  T             ++TW     
Sbjct: 500  ANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGR 558

Query: 565  GNGEIQNYKLYYMEKGTDKEQDVDVS---SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
               E+ +   Y++E G      +D S   ++S   +      E   +++     GP    
Sbjct: 559  DLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGP---- 614

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
              V    LSD          L +     + + W P      N  I  Y I +       +
Sbjct: 615  --VPRLVLSD----------LHLLTQSQVRVSWSP--AEDHNAPIEKYDIEFEDKEMAPE 660

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
               +L  V G Q S  ++ L     Y FRV A+   G G  +             E    
Sbjct: 661  KWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 719

Query: 740  EVPSSLHVRPLVTSIVVSWTPPE--NQNIVVRGYAIGY---GIGSPHAQTIKVDYKQRYY 794
            +V    +     T++V++W P    + N     Y + +   G   P  + I  D    + 
Sbjct: 720  DVKGEGNE---TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSD---PFL 773

Query: 795  TIENLDPSSHYVITLKAFNNVGEG----IPLYESAVTRPHTDTSEVDLFVINAPYTPVPD 850
             + N      Y I ++A N+ G+G    + +  S    P        + ++N+    V  
Sbjct: 774  VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV-- 831

Query: 851  PTPMMPPVGVQASILSH-DTIRIT-WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA 908
                  PV + A +  H     +T W + S  KH K    + + V     +PAN      
Sbjct: 832  ---KWRPVDL-AQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV-----VPAN------ 876

Query: 909  NATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEG 968
               T S +++GL+P + Y   V    GR S   S     T     P   P     +  E 
Sbjct: 877  ---TTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLEC 928

Query: 969  KPKT-IIVNWQPPSEANGKITGYIIYY---STDVNAEIHDWVIEPVVGNRLTHQIQELTL 1024
            +  T +++ WQPP   NG +TGY++ Y         ++   + +P +    TH + +L+ 
Sbjct: 929  QSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPEL---RTHNLTDLSP 985

Query: 1025 DTPYYFKIQARNSKGMG 1041
               Y F++QA   +G G
Sbjct: 986  HLRYRFQLQATTKEGPG 1002



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 79/344 (22%), Positives = 130/344 (37%), Gaps = 78/344 (22%)

Query: 741  VPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIG-----------YGIGSPHAQTIKVDY 789
            V S LH+    + + VSW+P E+ N  +  Y I            Y +G       KV  
Sbjct: 619  VLSDLHLLTQ-SQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLG-------KVPG 670

Query: 790  KQRYYTIENLDPSSHYVITLKAFNNVGEG--IPLYESAVTRPHTDTSEVDLFVINAPYTP 847
             Q   T++ L P  HY   + A N  G G   P+ E+ VT                    
Sbjct: 671  NQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-------------------- 709

Query: 848  VPDPTPMMPPVGVQASILSHDTIRITWA-----DNSLPKHQKITDSRYYTVRWKTNIPAN 902
             P+  P   PV V+        + ITW      D + P+ Q       Y V+W+   P  
Sbjct: 710  -PEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWR---PQG 758

Query: 903  TK--YKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPK- 959
            T+  ++    +    +V+       YE  V     +          G + E  P + P+ 
Sbjct: 759  TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPEL 818

Query: 960  -DVTVVSKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIH-------DWVIEP 1009
              + +++       ++V W+P   ++  G + GY + Y  + +   H       D V+ P
Sbjct: 819  EGIEILNSSA----VLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVP 874

Query: 1010 VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
               N  +  +  L   + Y+ ++QA N +G GP SE   F TP+
Sbjct: 875  A--NTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPE 915



 Score = 38.1 bits (87), Expect = 0.063
 Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 9/97 (9%)

Query: 345 KQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSD-----YFKIVKEHNLQVLG 399
           + P  +    + DI  +CE +GKP    +W ++G    P +      ++     +  + G
Sbjct: 40  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99

Query: 400 ----LVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
                 +  +G Y+C A N +G A +    ++ E AP
Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP 136



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 38/165 (23%), Positives = 65/165 (39%), Gaps = 18/165 (10%)

Query: 233 DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTE 292
           +E E   + +P VI++    + P  LV     D+ L C ASG P    +W +  + +  +
Sbjct: 24  EEYEGHHVMEPPVITE----QSPRRLVVFPTDDISLKCEASGKPEVQFRWTR--DGVHFK 77

Query: 293 SSERLVLLA-----GGSLEI----SDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQPE 342
             E L +        GS  I    S+  +   G Y C A N   T +  +  L  +  P+
Sbjct: 78  PKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPK 137

Query: 343 FLKQPTN-IYAHESMDIVFECEVTGKPTP-TVKWVKNGDMVIPSD 385
           + K+    +   E   +V  C       P  + W+ +  + I  D
Sbjct: 138 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQD 182


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
            sapiens]
          Length = 1257

 Score =  229 bits (583), Expect = 2e-59
 Identities = 196/789 (24%), Positives = 340/789 (43%), Gaps = 72/789 (9%)

Query: 63   LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKP 122
            ++++G  ++L C A   P+P I+W                L P G +    V +  HNK 
Sbjct: 253  VALQGQPLVLECIAEGFPTPTIKW----------------LRPSGPMPADRVTYQNHNKT 296

Query: 123  ---------DEGYYQCVATVESLGTIISRTAKLI-VAGLPRFTSQPEPSSVYAGNNAILN 172
                     D+G Y+C+A   SLG+  +R A  + V   P +  +P+      G  A L+
Sbjct: 297  LQLLKVGEEDDGEYRCLAE-NSLGS--ARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 353

Query: 173  CEVNADLVPFVRWEQNRQPL--LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG-GPP 229
            C+V     P V W  N  P+  L  D+  ++  G L++SN    D  + +C   +  G  
Sbjct: 354  CQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLL 413

Query: 230  KYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL 289
              +  + +  LP   + +D          + V G    L C A G P P+++W+ +E+  
Sbjct: 414  LANAYIYVVQLPAKILTAD------NQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGT 466

Query: 290  DTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTN 349
                 ER    A G+L I D+  +D G YFC+A N    +   A L V+   +  + P +
Sbjct: 467  TVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRS 526

Query: 350  IYAHESMDIVFECEVTGKPT--PTVKWVKNG-DMVIPSDYFK-IVKEHNLQVLGLVKSDE 405
                +   + F C+ +  P+  P++ W  +G D+    D  K  +++  L +  L  SD+
Sbjct: 527  TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586

Query: 406  GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASD 465
            G Y C+A  ++   ++ AQL+++     + GP+P      +  L  ++ ++++W +PA D
Sbjct: 587  GNYSCVASTELDVVESRAQLLVV----GSPGPVPRLVLSDLHLLTQSQ-VRVSW-SPAED 640

Query: 466  PHGDNLTYSVFYTKEGIARERVENTSH-PGEMQVTIQNLMPATVYIFRVMAQNKHGSGES 524
             +     Y + +  + +A E+  +    PG    T   L P   Y FRV A NK+G GE 
Sbjct: 641  HNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEP 700

Query: 525  SAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETP--VSGNGEIQNYKLYYMEKGT- 581
            S        PE        +++      T++ +TW+    +  N     Y++ +  +GT 
Sbjct: 701  SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 760

Query: 582  DKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLS 641
               Q+  VS     ++    +  Y  +V A N  G G         +  D P A P+   
Sbjct: 761  GPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEG 820

Query: 642  LEVRNSKSIMIHWQPPAPATQNGQITGYKIRY-------RKASRKSDVTETLVSGTQLSQ 694
            +E+ NS ++++ W+P   A   G + GY + Y       + + R       +V     S 
Sbjct: 821  IEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSV 880

Query: 695  LIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR-PLVTS 753
            ++ GL   + Y+  V A    G+GPA+++    TF +      VP  P +LH+     TS
Sbjct: 881  ILSGLRPYSSYHLEVQAFNGRGSGPASEF----TFST---PEGVPGHPEALHLECQSNTS 933

Query: 754  IVVSWTPPENQNIVVRGYAIGYGI----GSPHAQTIKVDYKQRYYTIENLDPSSHYVITL 809
            +++ W PP + N V+ GY + Y      G         D + R + + +L P   Y   L
Sbjct: 934  LLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQL 993

Query: 810  KAFNNVGEG 818
            +A    G G
Sbjct: 994  QATTKEGPG 1002



 Score =  145 bits (365), Expect = 4e-34
 Identities = 231/1037 (22%), Positives = 395/1037 (38%), Gaps = 121/1037 (11%)

Query: 51   TPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL--PDGS 108
            +P   +V P D +S       L C A  +P  +  W +DG       +    +   P   
Sbjct: 41   SPRRLVVFPTDDIS-------LKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 109  LFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGN 167
             F     +S   +  +G Y+C A+   LGT +S   +L+  G P++  +  +P  V  G 
Sbjct: 94   SFTITGNNSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152

Query: 168  NAILNCEVNADLVPFVRWEQNRQPLLL--DDRVIKLPSGMLVISNATEGDGGL-YRCVVE 224
            + +L C       P   +  N + L +  D+RV    +G L  +N    D    Y C   
Sbjct: 153  SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212

Query: 225  SGGPPKY--SDEVELKVLPDPEVISDLVFLKQP----SPLVRVIGQDVVLPCVASGLPTP 278
              G       + ++L+V     +I     L  P    S LV + GQ +VL C+A G PTP
Sbjct: 213  FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTP 272

Query: 279  TIKWMKNEEALDTESSERLVLL-AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTV 337
            TIKW++    +    ++R+       +L++  V E+D G Y C+A+N   +      +TV
Sbjct: 273  TIKWLRPSGPM---PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329

Query: 338  QAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYFKIVKEHNL 395
            +A P +L +P +           +C+V G+P P V W  NG  V  +  D    ++   L
Sbjct: 330  EAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGAL 389

Query: 396  QVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFI 455
             +  +  SD    QC A N  G   A A + +++  PA    L +  +  +A   ST ++
Sbjct: 390  ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ-LPAKI--LTADNQTYMAVQGSTAYL 446

Query: 456  KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMA 515
                        G  +    +  ++G    + E         + I++L       +  +A
Sbjct: 447  -------LCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLA 499

Query: 516  QNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT-----------SITVTWETPVS 564
             N   +    A L+V+   ++   GP   +    +  T             ++TW     
Sbjct: 500  ANDQNNVTIMANLKVKDATQI-TQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGR 558

Query: 565  GNGEIQNYKLYYMEKGTDKEQDVDVS---SHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
               E+ +   Y++E G      +D S   ++S   +      E   +++     GP    
Sbjct: 559  DLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGP---- 614

Query: 622  PDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSD 681
              V    LSD          L +     + + W P      N  I  Y I +       +
Sbjct: 615  --VPRLVLSD----------LHLLTQSQVRVSWSP--AEDHNAPIEKYDIEFEDKEMAPE 660

Query: 682  VTETL--VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVP 739
               +L  V G Q S  ++ L     Y FRV A+   G G  +             E    
Sbjct: 661  KWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 719

Query: 740  EVPSSLHVRPLVTSIVVSWTPPE--NQNIVVRGYAIGY---GIGSPHAQTIKVDYKQRYY 794
            +V    +     T++V++W P    + N     Y + +   G   P  + I  D    + 
Sbjct: 720  DVKGEGNE---TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSD---PFL 773

Query: 795  TIENLDPSSHYVITLKAFNNVGEG----IPLYESAVTRPHTDTSEVDLFVINAPYTPVPD 850
             + N      Y I ++A N+ G+G    + +  S    P        + ++N+    V  
Sbjct: 774  VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV-- 831

Query: 851  PTPMMPPVGVQASILSH-DTIRIT-WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA 908
                  PV + A +  H     +T W + S  KH K    + + V     +PAN      
Sbjct: 832  ---KWRPVDL-AQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV-----VPAN------ 876

Query: 909  NATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEG 968
               T S +++GL+P + Y   V    GR S   S     T     P   P     +  E 
Sbjct: 877  ---TTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLEC 928

Query: 969  KPKT-IIVNWQPPSEANGKITGYIIYY---STDVNAEIHDWVIEPVVGNRLTHQIQELTL 1024
            +  T +++ WQPP   NG +TGY++ Y         ++   + +P +    TH + +L+ 
Sbjct: 929  QSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPEL---RTHNLTDLSP 985

Query: 1025 DTPYYFKIQARNSKGMG 1041
               Y F++QA   +G G
Sbjct: 986  HLRYRFQLQATTKEGPG 1002



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 79/344 (22%), Positives = 130/344 (37%), Gaps = 78/344 (22%)

Query: 741  VPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIG-----------YGIGSPHAQTIKVDY 789
            V S LH+    + + VSW+P E+ N  +  Y I            Y +G       KV  
Sbjct: 619  VLSDLHLLTQ-SQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLG-------KVPG 670

Query: 790  KQRYYTIENLDPSSHYVITLKAFNNVGEG--IPLYESAVTRPHTDTSEVDLFVINAPYTP 847
             Q   T++ L P  HY   + A N  G G   P+ E+ VT                    
Sbjct: 671  NQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-------------------- 709

Query: 848  VPDPTPMMPPVGVQASILSHDTIRITWA-----DNSLPKHQKITDSRYYTVRWKTNIPAN 902
             P+  P   PV V+        + ITW      D + P+ Q       Y V+W+   P  
Sbjct: 710  -PEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWR---PQG 758

Query: 903  TK--YKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPK- 959
            T+  ++    +    +V+       YE  V     +          G + E  P + P+ 
Sbjct: 759  TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPEL 818

Query: 960  -DVTVVSKEGKPKTIIVNWQPP--SEANGKITGYIIYYSTDVNAEIH-------DWVIEP 1009
              + +++       ++V W+P   ++  G + GY + Y  + +   H       D V+ P
Sbjct: 819  EGIEILNSSA----VLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVP 874

Query: 1010 VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
               N  +  +  L   + Y+ ++QA N +G GP SE   F TP+
Sbjct: 875  A--NTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPE 915



 Score = 38.1 bits (87), Expect = 0.063
 Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 9/97 (9%)

Query: 345 KQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSD-----YFKIVKEHNLQVLG 399
           + P  +    + DI  +CE +GKP    +W ++G    P +      ++     +  + G
Sbjct: 40  QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99

Query: 400 ----LVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
                 +  +G Y+C A N +G A +    ++ E AP
Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP 136



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 38/165 (23%), Positives = 65/165 (39%), Gaps = 18/165 (10%)

Query: 233 DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTE 292
           +E E   + +P VI++    + P  LV     D+ L C ASG P    +W +  + +  +
Sbjct: 24  EEYEGHHVMEPPVITE----QSPRRLVVFPTDDISLKCEASGKPEVQFRWTR--DGVHFK 77

Query: 293 SSERLVLLA-----GGSLEI----SDVTEDDAGTYFCIADNGNET-IEAQAELTVQAQPE 342
             E L +        GS  I    S+  +   G Y C A N   T +  +  L  +  P+
Sbjct: 78  PKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPK 137

Query: 343 FLKQPTN-IYAHESMDIVFECEVTGKPTP-TVKWVKNGDMVIPSD 385
           + K+    +   E   +V  C       P  + W+ +  + I  D
Sbjct: 138 WPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQD 182


>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
            sapiens]
          Length = 1304

 Score =  229 bits (583), Expect = 2e-59
 Identities = 218/803 (27%), Positives = 344/803 (42%), Gaps = 79/803 (9%)

Query: 65   VRGSSVILNCSAYSEPSPKIEW-KKDGTFLNLVSDDRRQLLPDGSLFISN------VVHS 117
            +RG+ + L C A   P+P I W K+DG            +LP       N      ++H 
Sbjct: 283  LRGNVLSLECIAEGLPTPIIYWAKEDG------------MLPKNRTVYKNFEKTLQIIHV 330

Query: 118  KHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNA 177
              ++ D G YQC+A   +LG  I  T  + V   P + + P+   +  G +  L C  N 
Sbjct: 331  --SEADSGNYQCIAK-NALGA-IHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANG 386

Query: 178  DLVPFVRWEQNRQPLLL--DDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEV 235
            +  P + W  N  P+ +  DD   K+    ++ SN  E    +Y+C   +      ++  
Sbjct: 387  NPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAF 446

Query: 236  ELKVLPDPEVISDLVFLKQPSPLVRVI-GQDVVLPCVASGLPTPTIKWMKNEEALDTESS 294
             + VL +P  I     L   + L +VI  +  +L C   G P PTI+W K  +       
Sbjct: 447  -VNVLAEPPRI-----LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKG-SALHE 499

Query: 295  ERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHE 354
            +  VL   G+LEI    +D  GTY C+A N     + +  L ++     +KQP       
Sbjct: 500  DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 559

Query: 355  SMDIVFECEVTGKPT--PTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIA 412
               + FEC+V    T   TV W+K+   +   + F + K+H L V  +   D G Y C+A
Sbjct: 560  GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH-LVVADVSDDDSGTYTCVA 618

Query: 413  ENDVGNAQAGAQLIIL--EHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDN 470
               + +  A A L ++     PA    +P+ P D+  +    + ++L+W TP  D +   
Sbjct: 619  NTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSW-TPGDDNNSPI 677

Query: 471  LTYSVFYT----KEGIARERVENTSHPGEMQVTIQ-NLMPATVYIFRVMAQNKHGSGESS 525
              + + Y     K G+   + E +      Q T Q  L P   Y FRVMA N  G    S
Sbjct: 678  TKFIIEYEDAMHKPGLWHHQTEVSG----TQTTAQLKLSPYVNYSFRVMAVNSIG---KS 730

Query: 526  APLRVETQPEVQLPGPAPN---LRAYAASPTSITVTWETPVSG---NGEIQNYKLYYMEK 579
             P     Q   +   P  N   +    + P ++ +TW+ P++G   NG    YK+ + +K
Sbjct: 731  LPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK-PLNGFESNGPGLQYKVSWRQK 789

Query: 580  -GTDKEQDVDVSSHS-YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAP 637
             G D+   V V++ S Y ++G   +  Y  +V A N  G       V   +  D+P  AP
Sbjct: 790  DGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAP 849

Query: 638  QNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLV-------SGT 690
             N+ + V NS    +HW P    +  G + GY+I Y K    S      +        G+
Sbjct: 850  GNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGS 909

Query: 691  QLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH-VRP 749
            +   ++ GL+  + Y   V  +   G GPA+      T E       VP  PSSL  V P
Sbjct: 910  KTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEG------VPSAPSSLKIVNP 963

Query: 750  LVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYK----QRYYTIENLDPSSH 804
             + S+ + W PP + N ++  Y + Y  I S H     VD K    +  +T++NL+ S+ 
Sbjct: 964  TLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTR 1023

Query: 805  YVITLKAFNNVGEGIPLYESAVT 827
            Y     A  + G G  + E AVT
Sbjct: 1024 YKFYFYAQTSAGSGSQITEEAVT 1046



 Score =  177 bits (449), Expect = 7e-44
 Identities = 245/1084 (22%), Positives = 406/1084 (37%), Gaps = 150/1084 (13%)

Query: 59   PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSK 118
            P D +     ++++ C A  +P P   W ++GT  ++  D    + P     I N++   
Sbjct: 53   PKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEG 112

Query: 119  HNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGNNAILNCEVNA 177
              +  EG YQC A  E  G  +S    +  +  P +T +  EP ++ +G + +L C    
Sbjct: 113  KAETYEGVYQCTARNER-GAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPI 171

Query: 178  DLVP-FVRWEQNR-QPLLLDDRVIKLPSGMLVISNATEGDGGL-YRCVVESGGPPKYSDE 234
             L P  + W  N  Q L   +RV +  +G L  SN    D    Y C            +
Sbjct: 172  GLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQK 231

Query: 235  --VELKVLPDPEV-------ISDLVFLKQPSPLVR----------------VIGQDVVLP 269
              + +KV+   E+       +SD  F    S   R                + G  + L 
Sbjct: 232  QPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLE 291

Query: 270  CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
            C+A GLPTP I W K +  L    +  +      +L+I  V+E D+G Y CIA N    I
Sbjct: 292  CIAEGLPTPIIYWAKEDGMLP--KNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAI 349

Query: 330  EAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYF 387
                 + V+A P ++  P N+      D    C   G P P + W+ NG  +   P D  
Sbjct: 350  HHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPS 409

Query: 388  KIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-------LPS 440
            + +    +    + +     YQC A N+ G   A A + +L   P    P       + +
Sbjct: 410  RKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN 469

Query: 441  APRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTI 500
             P  +  +   +    + W   A    G  L   ++   E             G +++ +
Sbjct: 470  RPALLDCAFFGSPLPTIEWFKGAK---GSALHEDIYVLHEN------------GTLEIPV 514

Query: 501  QNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE-VQLPGPAPNLRAYAAS-------- 551
                    Y    +A+NK G  ++   L ++     V+ P  A   R    S        
Sbjct: 515  AQKDSTGTYT--CVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD 572

Query: 552  -PTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDV-DVSSHSYTINGLKKYTEYSFRV 609
               S+TV W   +  N E+ + + + ++K      DV D  S +YT          S   
Sbjct: 573  HTLSLTVLW---LKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASA 629

Query: 610  VAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 669
            V        V  P      + DVP+  P +L L  +  KS+ + W P      N  IT +
Sbjct: 630  VL------SVVAPTPTPAPVYDVPNP-PFDLELTDQLDKSVQLSWTPGDD--NNSPITKF 680

Query: 670  KIRYRKASRKSDVT--ETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAE 727
             I Y  A  K  +   +T VSGTQ +  ++ L     Y+FRV A  +N  G +    ++E
Sbjct: 681  IIEYEDAMHKPGLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMA--VNSIGKSLPSEASE 737

Query: 728  TFESDLDET-RVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIK 786
             + +   E  + P     L   P   ++V++W P             G+    P  Q  K
Sbjct: 738  QYLTKASEPDKNPTAVEGLGSEP--DNLVITWKPLN-----------GFESNGPGLQ-YK 783

Query: 787  VDYKQR---------------YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHT 831
            V ++Q+                Y +        Y+I ++A N++G      E AV   H+
Sbjct: 784  VSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAP---EPAVVMGHS 840

Query: 832  DTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYY 891
                              +  PM+ P  V+ ++++     + W    L   +      Y 
Sbjct: 841  G-----------------EDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQG-YR 882

Query: 892  TVRWKTNIPANTKYKNANATTLSY-------LVTGLKPNTLYEFSVMVTKGRRSSTWSMT 944
               WKT   +    ++     L++       ++ GL+P + Y  +V V  G+     S  
Sbjct: 883  IYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPD 942

Query: 945  AHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYII-YYSTDVNAEIH 1003
                T E VP S P  + +V+      T+   W PPS  NG +T Y + Y   +   E+ 
Sbjct: 943  RVFNTPEGVP-SAPSSLKIVNPTLDSLTL--EWDPPSHPNGILTEYTLKYQPINSTHELG 999

Query: 1004 DWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPND 1063
              V   +  N+    ++ L   T Y F   A+ S G G  S+  +      D +  +P D
Sbjct: 1000 PLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG--SQITEEAVTTVDEAGILPPD 1057

Query: 1064 QASG 1067
              +G
Sbjct: 1058 VGAG 1061



 Score =  142 bits (359), Expect = 2e-33
 Identities = 189/833 (22%), Positives = 333/833 (39%), Gaps = 105/833 (12%)

Query: 46   SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105
            S+R     Y++  P + +   G    L C A   P P+I W  +G  + +  DD  + + 
Sbjct: 354  SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKID 413

Query: 106  DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPR-FTSQPEPSSVY 164
              ++  SNV      +     YQC A+ E  G +++     ++A  PR  T       V 
Sbjct: 414  GDTIIFSNV-----QERSSAVYQCNASNE-YGYLLANAFVNVLAEPPRILTPANTLYQVI 467

Query: 165  AGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKL-PSGMLVISNATEGDGGLYRCVV 223
            A   A+L+C      +P + W +  +   L + +  L  +G L I  A +   G Y CV 
Sbjct: 468  ANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVA 527

Query: 224  ESG-GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPT--PTI 280
             +  G  K    +E+K   DP  I     +KQP   V   G  V   C      T   T+
Sbjct: 528  RNKLGMAKNEVHLEIK---DPTWI-----VKQPEYAVVQRGSMVSFECKVKHDHTLSLTV 579

Query: 281  KWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
             W+K+   L   S ER   +    L ++DV++DD+GTY C+A+   +++ A A L+V A 
Sbjct: 580  LWLKDNREL--PSDERFT-VDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVA- 635

Query: 341  PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVK--WVKNGDMVIPSDYFKIVKE------ 392
                  PT    ++  +  F+ E+T +   +V+  W    D   P   F I  E      
Sbjct: 636  ----PTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKP 691

Query: 393  ----HNLQVLGLVKSDE--------GFYQCIAENDVGN---AQAGAQLIIL----EHAPA 433
                H  +V G   + +          ++ +A N +G    ++A  Q +      +  P 
Sbjct: 692  GLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPT 751

Query: 434  TTGPLPSAPRDVVASLVSTRFIKLTWR-TPASDPHGDNLTYSVFYTKEGIARERVENTSH 492
                L S P ++V          +TW+     + +G  L Y V + ++    +   +   
Sbjct: 752  AVEGLGSEPDNLV----------ITWKPLNGFESNGPGLQYKVSWRQKD-GDDEWTSVVV 800

Query: 493  PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
                +  +        Y+ +V A N  G     A +   +  ++ +  P  N+R    + 
Sbjct: 801  ANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPG-NVRVNVVNS 859

Query: 553  TSITVTWETPV---SGNGEIQNYKLYYMEKGTDKEQD----------VDVSSHSYTINGL 599
            T   V W+ PV   S  G +Q Y++YY +  +  +++             S     + GL
Sbjct: 860  TLAEVHWD-PVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGL 918

Query: 600  KKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAP 659
            + ++ Y+  V   N  G G ++PD    T   VPS AP +L +      S+ + W P  P
Sbjct: 919  EPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDP--P 975

Query: 660  ATQNGQITGYKIRYRKASRKSD---VTETLVSGTQLSQLIEGLDRGTEYNFRVAALTING 716
            +  NG +T Y ++Y+  +   +   + +  +   +    ++ L+  T Y F   A T  G
Sbjct: 976  SHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAG 1035

Query: 717  TGPATDWLSAETFES------DLDETRVPEVP---SSLHVRPLVTSIVVSW--TPPENQN 765
            +G      +  T +       D+   +V  V    S+L      T   +SW    PE+ N
Sbjct: 1036 SGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVN 1095

Query: 766  IVVRGYAIGYGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVG 816
              V      YG+     +  K  V+  + ++ ++ L P + Y + + A  + G
Sbjct: 1096 FYVE-----YGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSG 1143



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 13/160 (8%)

Query: 237 LKVLPDPEVISDLV---FLKQPSPLVRVIG--QDVVLPCVASGLPTPTIKWMKNEEALDT 291
           L+V  DP+++ DLV    + Q SP   +I   +++V+ C A G P P+  W +N    D 
Sbjct: 30  LEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDI 89

Query: 292 ESSERLVLLAG-GSLEISDVTEDDA----GTYFCIADN-GNETIEAQAELTVQAQPEFLK 345
           +    + +  G G+L I+ ++E  A    G Y C A N     +     +     P + K
Sbjct: 90  DKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTK 149

Query: 346 QPTN-IYAHESMDIVFECE-VTGKPTPTVKWVKNGDMVIP 383
           +    I       +V  C    G P P + W+ N    +P
Sbjct: 150 EKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLP 189



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 9/105 (8%)

Query: 340 QPEFLKQ--PTNIYAHESMDIVFECEVTGKPTPTVKWVKNG-DMVIPSDYFKIVKEH--- 393
           QP  + Q  P +       +IV +CE  GKP P+  W +NG    I  D    +K     
Sbjct: 44  QPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT 103

Query: 394 ---NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATT 435
              N+   G  ++ EG YQC A N+ G A +   ++    +P  T
Sbjct: 104 LIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT 148



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 55/205 (26%), Positives = 81/205 (39%), Gaps = 23/205 (11%)

Query: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARER---VENTSHPG 494
            +PSAP  +     +   + L W  P S P+G    Y++ Y       E    V+      
Sbjct: 951  VPSAPSSLKIVNPTLDSLTLEW-DPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPAN 1009

Query: 495  EMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE------------VQLPGPA 542
            + + T++NL  +T Y F   AQ   GSG       V T  E            VQ   P 
Sbjct: 1010 KTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPR 1069

Query: 543  PNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKE---QDVDVSSHSYTINGL 599
             +    AA+ T   ++WE       E  N+ + Y   G+ +E   + V+ S   + + GL
Sbjct: 1070 ISNLTAAAAETYANISWEYE---GPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGL 1126

Query: 600  KKYTEYSFRVVAYNKHGPGVSTPDV 624
               T Y  RV A    G  VS+ DV
Sbjct: 1127 MPGTAYKVRVGAVGDSG-FVSSEDV 1150


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  228 bits (580), Expect = 4e-59
 Identities = 274/1070 (25%), Positives = 437/1070 (40%), Gaps = 143/1070 (13%)

Query: 55   FLVEPVDT---LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
            F+ EP      L      V LNC     P P I WK +GT ++   D R  ++ +GSL I
Sbjct: 28   FIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVV-EGSLLI 86

Query: 112  SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS-SVYAGNNAI 170
            +N     +   D G YQC AT  S GTI+SR AKL  A L  F ++   + SV  G   +
Sbjct: 87   NN----PNKTQDAGTYQCTAT-NSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141

Query: 171  LNC--EVNADLVPFVRWEQNRQPLLLDDR-VIKLPSGMLVISNATEGDGGLYRCVVESG- 226
            L C    ++  + +  W  N  P   D+R  +   +G L I+   + D G Y CVV +  
Sbjct: 142  LLCGPPPHSGELSYA-WIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTV 200

Query: 227  ------GPPK----YSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
                  GPP      +D V  +  P  EV       + P  +    G  V L C A G P
Sbjct: 201  TNHKVLGPPTPLILRNDGVMGEYEPKIEV-------QFPETVPTAKGATVKLECFALGNP 253

Query: 277  TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
             PTI W + +       + R    + G LEI +  ++DAG Y C+A+N      A+ +LT
Sbjct: 254  VPTIIWRRADGKPIARKARRHK--SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLT 311

Query: 337  VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ 396
              AQP ++++  +I+     ++ +EC+  G+P PT KW+KNG+ ++  D  +I ++  L 
Sbjct: 312  FYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI-EQGTLN 370

Query: 397  VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIK 456
            +  +  SD G YQC+AEN  G   + A+L ++   P  +  L         +LV      
Sbjct: 371  ITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKR-----VTLVKVGGEV 425

Query: 457  LTWRTPASDPHGDNLTYSVFYTKEG--IARERVENT-SHPGEMQVTIQNLMPATVYIFRV 513
            +    P + P        V+  K+G  I +E    T S  G +++   N+  +    +  
Sbjct: 426  VIECKPKASPK------PVYTWKKGRDILKENERITISEDGNLRII--NVTKSDAGSYTC 477

Query: 514  MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV------SGNG 567
            +A N  G+  S+  L V+    V +P  + ++    +      VT +  +      S NG
Sbjct: 478  IATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 537

Query: 568  EIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
             + ++         D++ D     H   + G     +   R +     G  V     +V 
Sbjct: 538  HLIDF---------DRDGD-----HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVD 583

Query: 628  TLSDV-------PSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA---- 676
             LS         P   P+ ++++     +  + W+P      +  IT Y I+ R      
Sbjct: 584  RLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRP--GPDNHSPITMYVIQARTPFSVG 641

Query: 677  -SRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735
                S V E L+ G   +  + GL+   EY FR  A  + G G  +        E  L E
Sbjct: 642  WQAVSTVPE-LIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPE 700

Query: 736  TRVPEVPSSLHVRPLVTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTI-------K 786
                 V      +   + +V++W   P E QN    GY + +    P+ + I        
Sbjct: 701  VTPANVSGGGGSK---SELVITWETVPEELQNGRGFGYVVAF---RPYGKMIWMLTVLAS 754

Query: 787  VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
             D  +  +  E++ P S + + +  FNN GEG          P + T+ V        Y+
Sbjct: 755  ADASRYVFRNESVHPFSPFEVKVGVFNNKGEG----------PFSPTTVV--------YS 796

Query: 847  PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK-TNIPANTKY 905
               +PT   PP  + A  LS   I + WA        +I    Y    W+  +   N + 
Sbjct: 797  AEEEPT--KPPASIFARSLSATDIEVFWASPLEKNRGRI--QGYEVKYWRHEDKEENARK 852

Query: 906  KNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVS 965
                    S  +T LK + LY  +V       +   S T + TT +  P+ PP ++   S
Sbjct: 853  IRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS 912

Query: 966  KEGKPKTIIVNWQPPS--EANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT 1023
             + K   II+NW      +   ++ GY + Y    N +    VIE    N+ + ++  L 
Sbjct: 913  SDSK---IILNWDQVKALDNESEVKGYKVLYRW--NRQSSTSVIET---NKTSVEL-SLP 963

Query: 1024 LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGS 1073
             D  Y  +I+  +  G G  SE  Q R P      K+ N  A GSG   S
Sbjct: 964  FDEDYIIEIKPFSDGGDGSSSE--QIRIP------KISNAYARGSGASTS 1005


>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
            sapiens]
          Length = 1183

 Score =  226 bits (576), Expect = 1e-58
 Identities = 216/801 (26%), Positives = 343/801 (42%), Gaps = 85/801 (10%)

Query: 65   VRGSSVILNCSAYSEPSPKIEW-KKDGTFLNLVSDDRRQLLPDGSLFISN------VVHS 117
            +RG+ + L C A   P+P I W K+DG            +LP       N      ++H 
Sbjct: 277  LRGNVLSLECIAEGLPTPIIYWAKEDG------------MLPKNRTVYKNFEKTLQIIHV 324

Query: 118  KHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNA 177
              ++ D G YQC+A   +LG I   T  + V   P + + P+   +  G +  L C  N 
Sbjct: 325  --SEADSGNYQCIAK-NALGAI-HHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANG 380

Query: 178  DLVPFVRWEQNRQPLLL--DDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEV 235
            +  P + W  N  P+ +  DD   K+    ++ SN  E    +Y+C   +      ++  
Sbjct: 381  NPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAF 440

Query: 236  ELKVLPDPEVISDLVFLKQPSPLVRVIG-QDVVLPCVASGLPTPTIKWMKNEEALDTESS 294
             + VL +P  I     L   + L +VI  +  +L C   G P PTI+W K  +       
Sbjct: 441  -VNVLAEPPRI-----LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKG-SALHE 493

Query: 295  ERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHE 354
            +  VL   G+LEI    +D  GTY C+A N     + +  L ++     +KQP       
Sbjct: 494  DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553

Query: 355  SMDIVFECEVTGKPTP--TVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIA 412
               + FEC+V    T   TV W+K+   +   + F + K+H L V  +   D G Y C+A
Sbjct: 554  GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH-LVVADVSDDDSGTYTCVA 612

Query: 413  ENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLT 472
               + +  A A L +++        +P+ P D+  +    + ++L+W TP  D +     
Sbjct: 613  NTTLDSVSASAVLSVVD--------VPNPPFDLELTDQLDKSVQLSW-TPGDDNNSPITK 663

Query: 473  YSVFYT----KEGIARERVENTSHPGEMQVTIQ-NLMPATVYIFRVMAQNKHGSGESSAP 527
            + + Y     K G+   + E +      Q T Q  L P   Y FRVMA N  G    S P
Sbjct: 664  FIIEYEDAMHKPGLWHHQTEVSG----TQTTAQLKLSPYVNYSFRVMAVNSIGK---SLP 716

Query: 528  LRVETQPEVQLPGPAPN---LRAYAASPTSITVTWETPVSG---NGEIQNYKLYYMEK-G 580
                 Q   +   P  N   +    + P ++ +TW+ P++G   NG    YK+ + +K G
Sbjct: 717  SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK-PLNGFESNGPGLQYKVSWRQKDG 775

Query: 581  TDKEQDVDVSSHS-YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQN 639
             D+   V V++ S Y ++G   +  Y  +V A N  G       V   +  D+P  AP N
Sbjct: 776  DDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGN 835

Query: 640  LSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVS-------GTQL 692
            + + V NS    +HW P    +  G + GY+I Y K    S      +        G++ 
Sbjct: 836  VRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKT 895

Query: 693  SQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH-VRPLV 751
              ++ GL+  + Y   V  +   G GPA+      T E       VP  PSSL  V P +
Sbjct: 896  HGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEG------VPSAPSSLKIVNPTL 949

Query: 752  TSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYK----QRYYTIENLDPSSHYV 806
             S+ + W PP + N ++  Y + Y  I S H     VD K    +  +T++NL+ S+ Y 
Sbjct: 950  DSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYK 1009

Query: 807  ITLKAFNNVGEGIPLYESAVT 827
                A  + G G  + E AVT
Sbjct: 1010 FYFYAQTSAGSGSQITEEAVT 1030



 Score =  171 bits (434), Expect = 4e-42
 Identities = 241/1058 (22%), Positives = 398/1058 (37%), Gaps = 158/1058 (14%)

Query: 59   PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSK 118
            P D +     ++++ C A  +P P   W ++GT  ++  D    + P     I N++   
Sbjct: 47   PKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEG 106

Query: 119  HNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGNNAILNCEVNA 177
              +  EG YQC A  E  G  +S    +  +  P +T +  EP ++ +G + +L C    
Sbjct: 107  KAETYEGVYQCTARNER-GAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPI 165

Query: 178  DLVP-FVRWEQNR-QPLLLDDRVIKLPSGMLVISNATEGDGGL-YRCVVESGGPPKYSDE 234
             L P  + W  N  Q L   +RV +  +G L  SN    D    Y C            +
Sbjct: 166  GLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQK 225

Query: 235  --VELKVLPDPEV-------ISDLVFLKQPSPLVR----------------VIGQDVVLP 269
              + +KV+   E+       +SD  F    S   R                + G  + L 
Sbjct: 226  QPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLE 285

Query: 270  CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
            C+A GLPTP I W K +  L    +  +      +L+I  V+E D+G Y CIA N    I
Sbjct: 286  CIAEGLPTPIIYWAKEDGMLP--KNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAI 343

Query: 330  EAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYF 387
                 + V+A P ++  P N+      D    C   G P P + W+ NG  +   P D  
Sbjct: 344  HHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPS 403

Query: 388  KIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-------LPS 440
            + +    +    + +     YQC A N+ G   A A + +L   P    P       + +
Sbjct: 404  RKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN 463

Query: 441  APRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTI 500
             P  +  +   +    + W   A    G  L   ++   E             G +++ +
Sbjct: 464  RPALLDCAFFGSPLPTIEWFKGAK---GSALHEDIYVLHEN------------GTLEIPV 508

Query: 501  QNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE-VQLPGPAPNLRAYAAS-------- 551
                    Y    +A+NK G  ++   L ++     V+ P  A   R    S        
Sbjct: 509  AQKDSTGTYT--CVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD 566

Query: 552  -PTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDV-DVSSHSYTINGLKKYTEYSFRV 609
               S+TV W   +  N E+ + + + ++K      DV D  S +YT              
Sbjct: 567  HTLSLTVLW---LKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTC------------- 610

Query: 610  VAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 669
               N     VS    AV ++ DVP+  P +L L  +  KS+ + W P      N  IT +
Sbjct: 611  -VANTTLDSVSAS--AVLSVVDVPNP-PFDLELTDQLDKSVQLSWTPGDD--NNSPITKF 664

Query: 670  KIRYRKASRKSDVT--ETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAE 727
             I Y  A  K  +   +T VSGTQ +  ++ L     Y+FRV A  +N  G +    ++E
Sbjct: 665  IIEYEDAMHKPGLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMA--VNSIGKSLPSEASE 721

Query: 728  TFESDLDET-RVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIK 786
             + +   E  + P     L   P   ++V++W P             G+    P  Q  K
Sbjct: 722  QYLTKASEPDKNPTAVEGLGSEP--DNLVITWKPLN-----------GFESNGPGLQ-YK 767

Query: 787  VDYKQR---------------YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHT 831
            V ++Q+                Y +        Y+I ++A N++G      E AV   H+
Sbjct: 768  VSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAP---EPAVVMGHS 824

Query: 832  DTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYY 891
                              +  PM+ P  V+ ++++     + W    L   +      Y 
Sbjct: 825  G-----------------EDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQG-YR 866

Query: 892  TVRWKTNIPANTKYKNANATTLSY-------LVTGLKPNTLYEFSVMVTKGRRSSTWSMT 944
               WKT   +    ++     L++       ++ GL+P + Y  +V V  G+     S  
Sbjct: 867  IYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPD 926

Query: 945  AHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYII-YYSTDVNAEIH 1003
                T E VP S P  + +V+      T+   W PPS  NG +T Y + Y   +   E+ 
Sbjct: 927  RVFNTPEGVP-SAPSSLKIVNPTLDSLTL--EWDPPSHPNGILTEYTLKYQPINSTHELG 983

Query: 1004 DWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMG 1041
              V   +  N+    ++ L   T Y F   A+ S G G
Sbjct: 984  PLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1021



 Score =  132 bits (331), Expect = 3e-30
 Identities = 165/722 (22%), Positives = 288/722 (39%), Gaps = 97/722 (13%)

Query: 46   SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105
            S+R     Y++  P + +   G    L C A   P P+I W  +G  + +  DD  + + 
Sbjct: 348  SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKID 407

Query: 106  DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPR-FTSQPEPSSVY 164
              ++  SNV      +     YQC A+ E  G +++     ++A  PR  T       V 
Sbjct: 408  GDTIIFSNV-----QERSSAVYQCNASNE-YGYLLANAFVNVLAEPPRILTPANTLYQVI 461

Query: 165  AGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKL-PSGMLVISNATEGDGGLYRCVV 223
            A   A+L+C      +P + W +  +   L + +  L  +G L I  A +   G Y CV 
Sbjct: 462  ANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVA 521

Query: 224  ESG-GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPT--PTI 280
             +  G  K    +E+K   DP  I     +KQP   V   G  V   C      T   T+
Sbjct: 522  RNKLGMAKNEVHLEIK---DPTWI-----VKQPEYAVVQRGSMVSFECKVKHDHTLSLTV 573

Query: 281  KWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
             W+K+   L   S ER   +    L ++DV++DD+GTY C+A+   +++ A A L+V   
Sbjct: 574  LWLKDNREL--PSDERFT-VDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDV 630

Query: 341  PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVK--WVKNGDMVIPSDYFKIVKE------ 392
            P               +  F+ E+T +   +V+  W    D   P   F I  E      
Sbjct: 631  P---------------NPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKP 675

Query: 393  ----HNLQVLGLVKSDE--------GFYQCIAENDVGN---AQAGAQLIIL----EHAPA 433
                H  +V G   + +          ++ +A N +G    ++A  Q +      +  P 
Sbjct: 676  GLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPT 735

Query: 434  TTGPLPSAPRDVVASLVSTRFIKLTWR-TPASDPHGDNLTYSVFYTKEGIARERVENTSH 492
                L S P ++V          +TW+     + +G  L Y V + ++    +   +   
Sbjct: 736  AVEGLGSEPDNLV----------ITWKPLNGFESNGPGLQYKVSWRQKD-GDDEWTSVVV 784

Query: 493  PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
                +  +        Y+ +V A N  G     A +   +  ++ +  P  N+R    + 
Sbjct: 785  ANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPG-NVRVNVVNS 843

Query: 553  TSITVTWETPV---SGNGEIQNYKLYYMEKGTDKEQD----------VDVSSHSYTINGL 599
            T   V W+ PV   S  G +Q Y++YY +  +  +++             S     + GL
Sbjct: 844  TLAEVHWD-PVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGL 902

Query: 600  KKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAP 659
            + ++ Y+  V   N  G G ++PD    T   VPS AP +L +      S+ + W P  P
Sbjct: 903  EPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDP--P 959

Query: 660  ATQNGQITGYKIRYRKASRKSD---VTETLVSGTQLSQLIEGLDRGTEYNFRVAALTING 716
            +  NG +T Y ++Y+  +   +   + +  +   +    ++ L+  T Y F   A T  G
Sbjct: 960  SHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAG 1019

Query: 717  TG 718
            +G
Sbjct: 1020 SG 1021



 Score =  102 bits (253), Expect = 4e-21
 Identities = 218/994 (21%), Positives = 361/994 (36%), Gaps = 170/994 (17%)

Query: 152  PRFTSQ-PEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDR---VIKLPSGMLV 207
            P  T Q P+   +    N ++ CE      P   W +N     +D      +K  +G L+
Sbjct: 40   PTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLI 99

Query: 208  ISNATEGDG----GLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIG 263
            I+  +EG      G+Y+C   +      S+ + ++    P     L   ++  P+    G
Sbjct: 100  INIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSP-----LWTKEKLEPITLQSG 154

Query: 264  QDVVLPCVAS-GLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVT-EDDAGTYFCI 321
            Q +VLPC    GLP P I WM N        SER+     G L  S+V  ED    Y C 
Sbjct: 155  QSLVLPCRPPIGLPPPIIFWMDNSFQR-LPQSERVSQGLNGDLYFSNVLPEDTREDYICY 213

Query: 322  A---------------------DNGNETIEAQ--------AELTVQAQPEFLKQPTNIYA 352
            A                     D  N+TI A         A+ + +  P FL    N   
Sbjct: 214  ARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASN 273

Query: 353  HESMD---IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQ 409
             E +    +  EC   G PTP + W K   M+  +       E  LQ++ + ++D G YQ
Sbjct: 274  KEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQ 333

Query: 410  CIAENDVGNAQAGAQLII------------LEHAPATTGPL----PSAPRDVVASLVSTR 453
            CIA+N +G       + +            L  +P   G L       P+  ++ L +  
Sbjct: 334  CIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGV 393

Query: 454  FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
             I++    P+    GD + +S                           N+   +  +++ 
Sbjct: 394  PIEIAPDDPSRKIDGDTIIFS---------------------------NVQERSSAVYQC 426

Query: 514  MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK 573
             A N++G   ++A + V  +P  ++  PA  L    A+  ++    +    G+  +   +
Sbjct: 427  NASNEYGYLLANAFVNVLAEPP-RILTPANTLYQVIANRPALL---DCAFFGS-PLPTIE 481

Query: 574  LYYMEKGTDKEQDVDVSSHSYTIN--GLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSD 631
             +   KG+   +D+ V   + T+     +K +  ++  VA NK G               
Sbjct: 482  WFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLG--------------- 526

Query: 632  VPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQ 691
                A   + LE+++   I+   QP     Q G +  ++ + +     S     L    +
Sbjct: 527  ---MAKNEVHLEIKDPTWIVK--QPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 581

Query: 692  L-SQLIEGLDRGTEYNFRVAALTINGTGPAT-------DWLSAETFESDLDETRVPEVPS 743
            L S     +D+    +  VA ++ + +G  T       D +SA    S +D   VP  P 
Sbjct: 582  LPSDERFTVDKD---HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD---VPNPPF 635

Query: 744  SLHVRP-LVTSIVVSWTPPENQNIVVRGYAIGYGI-----GSPHAQTIKVDYKQRYYTIE 797
             L +   L  S+ +SWTP ++ N  +  + I Y       G  H QT +V   Q    ++
Sbjct: 636  DLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQT-EVSGTQTTAQLK 694

Query: 798  NLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPP 857
             L P  +Y   + A N++G+ +P    A  +  T  SE D                   P
Sbjct: 695  -LSPYVNYSFRVMAVNSIGKSLP--SEASEQYLTKASEPD-----------------KNP 734

Query: 858  VGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLV 917
              V+      D + ITW    L   +       Y V W+     +       A    Y+V
Sbjct: 735  TAVEGLGSEPDNLVITW--KPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIV 792

Query: 918  TGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNW 977
            +G      Y   V        +       G + E +P   P +V V         +  + 
Sbjct: 793  SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 852

Query: 978  QPPSEANGKITGYIIYY-----STDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKI 1032
             P     G + GY IYY     S+  N    +  I    G++    +  L   + Y   +
Sbjct: 853  VPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNV 912

Query: 1033 QARNSKGMGPMSEAVQFRTPK----ADSSDKMPN 1062
            +  N KG GP S    F TP+    A SS K+ N
Sbjct: 913  RVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVN 946



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 148/637 (23%), Positives = 246/637 (38%), Gaps = 89/637 (13%)

Query: 56   LVEPVDTLS--VRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISN 113
            ++ P +TL   +     +L+C+ +  P P IEW K G   + + +D   L  +G+L I  
Sbjct: 450  ILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFK-GAKGSALHEDIYVLHENGTLEIPV 508

Query: 114  VVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNC 173
                   K   G Y CVA    LG +      L +        QPE + V  G+     C
Sbjct: 509  A-----QKDSTGTYTCVAR-NKLG-MAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFEC 561

Query: 174  EVNAD--LVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKY 231
            +V  D  L   V W ++ + L  D+R   +    LV+++ ++ D G Y CV  +      
Sbjct: 562  KVKHDHTLSLTVLWLKDNRELPSDER-FTVDKDHLVVADVSDDDSGTYTCVANTT-LDSV 619

Query: 232  SDEVELKVLPDPEVISDLVFLKQPSPLVRVI---GQDVVLPCVA------SGLPTPTIKW 282
            S    L V+  P    DL    Q    V++    G D   P           +  P + W
Sbjct: 620  SASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGL-W 678

Query: 283  MKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPE 342
                E   T+++ +L L    +     +  +  G           +  ++  LT  ++P+
Sbjct: 679  HHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSL-------PSEASEQYLTKASEPD 731

Query: 343  FLKQPTNI--YAHESMDIVFECEVTGKPTP-----------TVKW-VKNGD-----MVIP 383
              K PT +     E  ++V    +T KP              V W  K+GD     +V+ 
Sbjct: 732  --KNPTAVEGLGSEPDNLV----ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVA 785

Query: 384  SDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPS-AP 442
            +    IV      V  L+K         A ND+G A   A  +++ H+      LP  AP
Sbjct: 786  NVSKYIVSGTPTFVPYLIKVQ-------ALNDMGFAPEPA--VVMGHSGED---LPMVAP 833

Query: 443  RDVVASLVSTRFIKLTWR-TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQ 501
             +V  ++V++   ++ W   P     G    Y ++Y K   + +R  N  H  +  +T Q
Sbjct: 834  GNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKR--NRRHIEKKILTFQ 891

Query: 502  N---------LMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
                      L P + Y   V   N  G G +S P RV   PE  +P    +L+    + 
Sbjct: 892  GSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPAS-PDRVFNTPE-GVPSAPSSLKIVNPTL 949

Query: 553  TSITVTWETPVSGNGEIQNYKLYYM------EKGTDKEQDVDVSSHSYTINGLKKYTEYS 606
             S+T+ W+ P   NG +  Y L Y       E G   +  +  +   +T+  L   T Y 
Sbjct: 950  DSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYK 1009

Query: 607  FRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLE 643
            F   A    G G    + AV T+ +  ++   +++ +
Sbjct: 1010 FYFYAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQ 1046



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 9/105 (8%)

Query: 340 QPEFLKQ--PTNIYAHESMDIVFECEVTGKPTPTVKWVKNG-DMVIPSDYFKIVKEH--- 393
           QP  + Q  P +       +IV +CE  GKP P+  W +NG    I  D    +K     
Sbjct: 38  QPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT 97

Query: 394 ---NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATT 435
              N+   G  ++ EG YQC A N+ G A +   ++    +P  T
Sbjct: 98  LIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT 142



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 40/153 (26%), Positives = 63/153 (41%), Gaps = 13/153 (8%)

Query: 244 EVISDLV---FLKQPSPLVRVIG--QDVVLPCVASGLPTPTIKWMKNEEALDTESSERLV 298
           EV  DLV    + Q SP   +I   +++V+ C A G P P+  W +N    D +    + 
Sbjct: 31  EVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVT 90

Query: 299 LLAG-GSLEISDVTEDDA----GTYFCIADN-GNETIEAQAELTVQAQPEFLKQPTN-IY 351
           +  G G+L I+ ++E  A    G Y C A N     +     +     P + K+    I 
Sbjct: 91  MKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPIT 150

Query: 352 AHESMDIVFECE-VTGKPTPTVKWVKNGDMVIP 383
                 +V  C    G P P + W+ N    +P
Sbjct: 151 LQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLP 183



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 10/139 (7%)

Query: 956  SPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRL 1015
            +PP D+ +  +    K++ ++W P  + N  IT +II Y  D   +   W  +  V    
Sbjct: 632  NPPFDLELTDQ--LDKSVQLSWTPGDDNNSPITKFIIEYE-DAMHKPGLWHHQTEVSGTQ 688

Query: 1016 THQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRL 1075
            T    +L+    Y F++ A NS G    SEA +    KA   DK P    +   G GS  
Sbjct: 689  TTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNP----TAVEGLGSEP 744

Query: 1076 PDLGSDYKPPMSG--SNSP 1092
             +L   +K P++G  SN P
Sbjct: 745  DNLVITWK-PLNGFESNGP 762


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  223 bits (568), Expect = 1e-57
 Identities = 224/825 (27%), Positives = 342/825 (41%), Gaps = 100/825 (12%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 35  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 95  HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153

Query: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--- 264

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ  P F+ +P +    
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 324

Query: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVKSDE 405
               + F+CE TG P P + W + G   +   Y        F + +  +L +  + +SD 
Sbjct: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 384

Query: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
           G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T + 
Sbjct: 385 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSP 443

Query: 465 DPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
            P       ++ + K+G+       R++   + G +Q+    L     Y    +A    G
Sbjct: 444 VP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIASTPSG 493

Query: 521 SGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNGEIQ 570
               SA + V E    VQ P P  PNL   A         S  ++T++W+  ++      
Sbjct: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 553

Query: 571 NYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV--- 624
           +Y +      +         +V + +  I GLK    Y F V A N +  G+S P     
Sbjct: 554 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQISD 611

Query: 625 AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQITGY 669
            V+T   +P++             N  L + N     S SI +HW       Q+  I GY
Sbjct: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQGY 668

Query: 670 KIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLS 725
           KI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++   
Sbjct: 669 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 728

Query: 726 AETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAIGYG 776
           A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y + + 
Sbjct: 729 AKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WC 778

Query: 777 IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
           +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 779 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 823



 Score =  147 bits (371), Expect = 7e-35
 Identities = 219/896 (24%), Positives = 341/896 (38%), Gaps = 155/896 (17%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141

Query: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
             +G+  V+ C    G P PTI W K+   LD +  ER + + GG L I+   + DAG Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKY 199

Query: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L + E        
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-- 316

Query: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 317 ---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 368

Query: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 369 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 423

Query: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 424 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 482

Query: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 483 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 532

Query: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 533 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 587

Query: 702 GTEYNFRVAALTINGTG---------------PATDWLSAETFESDLDETRV----PEVP 742
              Y F V A    G                 P +  +  +  + +L    +    P V 
Sbjct: 588 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 647

Query: 743 SSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTI 796
           SS       +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I
Sbjct: 648 SS-------SSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 699

Query: 797 ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
            +L    +Y I  + F N  +G               SE+        +    +  P  P
Sbjct: 700 PDLRKGVNYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAP 739

Query: 857 PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL 916
           P GV  S    +   I  +    P+  +    + Y V    N       K  + +T S +
Sbjct: 740 PQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVV 799

Query: 917 VTGLKPNTLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
           +  L P   Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 800 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 850



 Score =  122 bits (305), Expect = 3e-27
 Identities = 189/864 (21%), Positives = 329/864 (38%), Gaps = 98/864 (11%)

Query: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 32   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 92   RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151

Query: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 152  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211

Query: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 212  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259

Query: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+  P   +
Sbjct: 260  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV 316

Query: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
              P   + A        TVT++   +GN +          QN    Y    +     V  
Sbjct: 317  K-PRDQVVALGR-----TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370

Query: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 371  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 426

Query: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 427  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 480

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 481  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540

Query: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 541  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 599

Query: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 600  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 647

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 648  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 706

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 707  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 766

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 767  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 823

Query: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
             SE  QF    A  +   P DQ S
Sbjct: 824  KSEP-QFIQLDAHGNPVSPEDQVS 846



 Score = 97.4 bits (241), Expect = 9e-20
 Identities = 147/630 (23%), Positives = 217/630 (34%), Gaps = 92/630 (14%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281

Query: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCE 174
                   D G Y CVA  E++      +A L V   P F  +P    V  G      CE
Sbjct: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334

Query: 175 VNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226
              +  P + W +        + QP     R     +G L I+N    D G Y C   + 
Sbjct: 335 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 394

Query: 227 GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGLPTP 278
                   +    L   +VI+D     +P P++R         +    VL CVA+G P P
Sbjct: 395 A----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445

Query: 279 TIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELT 336
           TI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  E+ 
Sbjct: 446 TILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504

Query: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNL 395
               P    +PT+     S     E     + T T+ W  N      P+ Y      H  
Sbjct: 505 EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSH-- 562

Query: 396 QVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDVV-- 446
                  +    +Q +AEN      A          L ++  A A     PS   D V  
Sbjct: 563 -------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 615

Query: 447 ----------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTYSVF 476
                                        +++S+  I++ W       +  G  + Y   
Sbjct: 616 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 675

Query: 477 YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
               G +   V     P +  V I +L     Y  +         G  S     +T  E 
Sbjct: 676 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 735

Query: 537 -QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVDVSS 591
              P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD S+
Sbjct: 736 PSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGST 795

Query: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S  I  L     YS  V A    G GV +
Sbjct: 796 FSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  223 bits (568), Expect = 1e-57
 Identities = 224/825 (27%), Positives = 342/825 (41%), Gaps = 100/825 (12%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 74  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 134 HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 192

Query: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 193 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 253 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--- 303

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ  P F+ +P +    
Sbjct: 304 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 363

Query: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVKSDE 405
               + F+CE TG P P + W + G   +   Y        F + +  +L +  + +SD 
Sbjct: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 423

Query: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
           G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T + 
Sbjct: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSP 482

Query: 465 DPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
            P       ++ + K+G+       R++   + G +Q+    L     Y    +A    G
Sbjct: 483 VP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIASTPSG 532

Query: 521 SGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNGEIQ 570
               SA + V E    VQ P P  PNL   A         S  ++T++W+  ++      
Sbjct: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 592

Query: 571 NYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV--- 624
           +Y +      +         +V + +  I GLK    Y F V A N +  G+S P     
Sbjct: 593 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQISD 650

Query: 625 AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQITGY 669
            V+T   +P++             N  L + N     S SI +HW       Q+  I GY
Sbjct: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQGY 707

Query: 670 KIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLS 725
           KI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++   
Sbjct: 708 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 767

Query: 726 AETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAIGYG 776
           A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y + + 
Sbjct: 768 AKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WC 817

Query: 777 IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
           +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 818 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 862



 Score =  147 bits (371), Expect = 7e-35
 Identities = 219/896 (24%), Positives = 341/896 (38%), Gaps = 155/896 (17%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 180

Query: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
             +G+  V+ C    G P PTI W K+   LD +  ER + + GG L I+   + DAG Y
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKY 238

Query: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L + E        
Sbjct: 299 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-- 355

Query: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 356 ---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 407

Query: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 408 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 462

Query: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 463 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 521

Query: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 522 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 571

Query: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 572 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 626

Query: 702 GTEYNFRVAALTINGTG---------------PATDWLSAETFESDLDETRV----PEVP 742
              Y F V A    G                 P +  +  +  + +L    +    P V 
Sbjct: 627 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686

Query: 743 SSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTI 796
           SS       +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I
Sbjct: 687 SS-------SSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 738

Query: 797 ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
            +L    +Y I  + F N  +G               SE+        +    +  P  P
Sbjct: 739 PDLRKGVNYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAP 778

Query: 857 PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL 916
           P GV  S    +   I  +    P+  +    + Y V    N       K  + +T S +
Sbjct: 779 PQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVV 838

Query: 917 VTGLKPNTLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
           +  L P   Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 839 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 889



 Score =  122 bits (305), Expect = 3e-27
 Identities = 189/864 (21%), Positives = 329/864 (38%), Gaps = 98/864 (11%)

Query: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 71   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 130

Query: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 131  RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 190

Query: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 191  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 250

Query: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 251  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 298

Query: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+  P   +
Sbjct: 299  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV 355

Query: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
              P   + A        TVT++   +GN +          QN    Y    +     V  
Sbjct: 356  K-PRDQVVALGR-----TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409

Query: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 410  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 465

Query: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 466  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 519

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 520  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 579

Query: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 580  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 638

Query: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 639  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 686

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 687  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 745

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 746  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 805

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 806  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 862

Query: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
             SE  QF    A  +   P DQ S
Sbjct: 863  KSEP-QFIQLDAHGNPVSPEDQVS 885



 Score = 97.4 bits (241), Expect = 9e-20
 Identities = 147/630 (23%), Positives = 217/630 (34%), Gaps = 92/630 (14%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 264 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 320

Query: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCE 174
                   D G Y CVA  E++      +A L V   P F  +P    V  G      CE
Sbjct: 321 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373

Query: 175 VNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226
              +  P + W +        + QP     R     +G L I+N    D G Y C   + 
Sbjct: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 433

Query: 227 GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGLPTP 278
                   +    L   +VI+D     +P P++R         +    VL CVA+G P P
Sbjct: 434 A----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484

Query: 279 TIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELT 336
           TI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  E+ 
Sbjct: 485 TILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543

Query: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNL 395
               P    +PT+     S     E     + T T+ W  N      P+ Y      H  
Sbjct: 544 EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSH-- 601

Query: 396 QVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDVV-- 446
                  +    +Q +AEN      A          L ++  A A     PS   D V  
Sbjct: 602 -------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 654

Query: 447 ----------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTYSVF 476
                                        +++S+  I++ W       +  G  + Y   
Sbjct: 655 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 714

Query: 477 YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
               G +   V     P +  V I +L     Y  +         G  S     +T  E 
Sbjct: 715 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 774

Query: 537 -QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVDVSS 591
              P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD S+
Sbjct: 775 PSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGST 834

Query: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S  I  L     YS  V A    G GV +
Sbjct: 835 FSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 12/119 (10%)

Query: 313 DDAGTYFCIADNGNETIEAQAELTVQAQ--PEFLKQPTNIYAHESMDIVFECEVTGKPTP 370
           +D GT    +DN + ++        Q    P  ++ P+++   +       C+  G+PTP
Sbjct: 38  NDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTP 97

Query: 371 TVKWVKNGDMV-----IPSDYFKIVKEHNLQVLGLV-----KSDEGFYQCIAENDVGNA 419
           T++W K G+ V      P  +  ++   +L  L +V     + DEG Y C+A N +G A
Sbjct: 98  TIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA 156


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  220 bits (561), Expect = 7e-57
 Identities = 273/1064 (25%), Positives = 444/1064 (41%), Gaps = 153/1064 (14%)

Query: 55   FLVEPVDTLSVRGSS---VILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
            F+ EP +++   GS    + L+C A   PSP   W+ +G+ +++ S + R  L  G+L +
Sbjct: 28   FIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDM-SMEHRYKLNGGNLVV 86

Query: 112  SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRF-TSQPEPSSVYAGNNAI 170
             N     +   D G YQC AT  SLGTI+SR AKL  A L  F T      SV  G   +
Sbjct: 87   IN----PNRNWDTGTYQCFAT-NSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVV 141

Query: 171  LNC--EVNADLVPFVRWEQNRQPLLLDD---RVIKLPSGMLVISNATEGDGGLYRCVVES 225
            L C    ++  + +  W  N  P  +++   R +   +G L IS     D G Y CVV S
Sbjct: 142  LLCGPPPHSGELSYA-WIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTS 200

Query: 226  --------GGPPKY---SDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASG 274
                    G P      SD V  +  P  EV       + P  L    G  V L C A G
Sbjct: 201  MVTNARVLGSPTPLVLRSDGVMGEYEPKIEV-------QFPETLPAAKGSTVKLECFALG 253

Query: 275  LPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAE 334
             P P I W +++  L   S  +L   +G  LEI +  ++DAG+Y CIA+N      A+  
Sbjct: 254  NPIPQINWRRSD-GLPFSSKIKLRKFSG-VLEIPNFQQEDAGSYECIAENSRGKNVARGR 311

Query: 335  LTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN 394
            LT  A+P +++   ++       + +EC  +GKP P+ +W+KNG  ++  +  +I +   
Sbjct: 312  LTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQI-ENGA 370

Query: 395  LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPA-TTGPLPSAPRDVVASLVSTR 453
            L +  L  +D G +QCIAEN  G   + A+L ++  AP  +  P+    +  V SLVS  
Sbjct: 371  LTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLD 430

Query: 454  FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
                    P + P   +      + K  ++ +  E  S   +  + I N+  A    +  
Sbjct: 431  C------KPRASPRALSS-----WKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTC 479

Query: 514  MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT-------------SITVTWE 560
            MA+N+ G    +  L V     + L   AP+    +   +              I  TW 
Sbjct: 480  MAENQFGKANGTTHLVVTEPTRITL---APSNMDVSVGESVILPCQVQHDPLLDIIFTWY 536

Query: 561  TPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVS 620
                 NG + ++K    + G+  E+    SS    I  ++   ++S + V   +   GV 
Sbjct: 537  F----NGALADFK----KDGSHFEKVGGSSSGDLMIRNIQ--LKHSGKYVCMVQ--TGVD 584

Query: 621  TPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA---- 676
            +   A   +       P+N+ ++     +  + W+       +  +  Y I+ R      
Sbjct: 585  SVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKD--NHSPVISYSIQARTPFSVG 642

Query: 677  -SRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735
                + V E +   T  + ++E L+   EY FRV A    G G  +  L +E   +   E
Sbjct: 643  WQTVTTVPEVIDGKTHTATVVE-LNPWVEYEFRVVASNKIGGGEPS--LPSEKVRT---E 696

Query: 736  TRVPEVPSSLHVRP---LVTSIVVSW--TPPENQNIVVRGYAIGY---GIGSPHAQTIKV 787
              VPEVP S  V       + +V++W   P E QN    GY + +   G+ +     +  
Sbjct: 697  EAVPEVPPS-EVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTS 755

Query: 788  DYKQRY-YTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
                RY +  E++ P S Y + +  +NN GEG                         P++
Sbjct: 756  PDTPRYVFRNESIVPYSPYEVKVGVYNNKGEG-------------------------PFS 790

Query: 847  PVP-----DPTPMMPPVGVQASILSHDTIRITWADNSLP-----KHQKITDSRYYTVRWK 896
            PV      +  P + P  V A+ LS   I ++W  N++P      H    + RY+    K
Sbjct: 791  PVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSW--NTIPWKLSNGHLLGYEVRYWNGGGK 848

Query: 897  TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS 956
                +++K K A   T + L  GLK N  Y  +V       +  +S T + TT +  P+ 
Sbjct: 849  EE--SSSKMKVAGNETSARL-RGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQ 905

Query: 957  PPKDVTVVSKEGKPKTIIVNWQ--PPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNR 1014
            PP +V   + + K   +++NW+     E   ++TGY ++Y T     +       V+   
Sbjct: 906  PPGNVVWNATDTK---VLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQ------VLNTN 956

Query: 1015 LTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSD 1058
             T     L +   Y  +++A    G G  SE  Q R P+  S D
Sbjct: 957  KTSAELVLPIKEDYIIEVKATTDGGDGTSSE--QIRIPRITSMD 998



 Score =  115 bits (289), Expect = 2e-25
 Identities = 215/968 (22%), Positives = 354/968 (36%), Gaps = 128/968 (13%)

Query: 145  KLIVAGLPRFTSQPEPSSVYAGNN---AILNCEVNADLVPFVRWEQNRQPLLLD-DRVIK 200
            +L++ G P F  +P  S    G+      L+CE   +  P  RW+ N   + +  +   K
Sbjct: 20   ELLLQG-PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYK 78

Query: 201  LPSGMLVISNATEG-DGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
            L  G LV+ N     D G Y+C   +      S E +L+       + +     + +  V
Sbjct: 79   LNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFA----YLENFKTKMRSTVSV 134

Query: 260  RVIGQDVVLPCVASGLPTP-----TIKWMKNE-EALDTESSERLVLLAGGSLEISDVTED 313
            R  GQ VVL C     P P     +  W+ NE  +   E S R V    G L IS V   
Sbjct: 135  RE-GQGVVLLCG----PPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPS 189

Query: 314  DAGTYFCIADN---GNETIEAQAELTVQA-------QPEFLKQ-PTNIYAHESMDIVFEC 362
            D G Y C+  +       + +   L +++       +P+   Q P  + A +   +  EC
Sbjct: 190  DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249

Query: 363  EVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN-LQVLGLVKSDEGFYQCIAENDVGNAQA 421
               G P P + W +  D +  S   K+ K    L++    + D G Y+CIAEN  G   A
Sbjct: 250  FALGNPIPQINW-RRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVA 308

Query: 422  GAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEG 481
              +L                 +DV  ++  +    L W   AS         S  + K G
Sbjct: 309  RGRLTYYAKPHWV-----QLIKDVEIAVEDS----LYWECRASGKPKP----SYRWLKNG 355

Query: 482  IA-----RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
             A     R ++EN +      +TI NL      +F+ +A+NKHG   SSA L+V      
Sbjct: 356  AALVLEERTQIENGA------LTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPD 409

Query: 537  QLPGPAPNL-RAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS-- 593
                P   L +    S  S+      P +    + ++K     KG     DV V  H   
Sbjct: 410  FSKNPMKKLVQVQVGSLVSLDCK---PRASPRALSSWK-----KG-----DVSVQEHERI 456

Query: 594  -------YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRN 646
                     I  + K    ++  +A N+ G    T  + V   + + + AP N+ + V  
Sbjct: 457  SLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRI-TLAPSNMDVSVGE 515

Query: 647  SKSI--MIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTE 704
            S  +   +   P           G    ++K     +      SG  + + I+      +
Sbjct: 516  SVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQ-----LK 570

Query: 705  YNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLV-TSIVVSWTPPEN 763
            ++ +   +   G    +         +DL     P  P ++ V  +  T+  +SW   ++
Sbjct: 571  HSGKYVCMVQTGVDSVSS-------AADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKD 623

Query: 764  QNIVVRGYAIG----YGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGE 817
             +  V  Y+I     + +G     T+   +D K    T+  L+P   Y   + A N +G 
Sbjct: 624  NHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGG 683

Query: 818  GIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADN 877
            G P   S   R                     +  P +PP  V     S   + ITW  +
Sbjct: 684  GEPSLPSEKVRTE-------------------EAVPEVPPSEVNGGGGSRSELVITW--D 722

Query: 878  SLPKHQKITDSRYYTVRWK---TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTK 934
             +P+  +  +   Y V ++         T   + +     +    + P + YE  V V  
Sbjct: 723  PVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYN 782

Query: 935  GRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYY 994
             +    +S      + E  PT  P  V+  S       +  N  P   +NG + GY + Y
Sbjct: 783  NKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRY 842

Query: 995  STDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA 1054
                  E     ++ V GN  + +++ L  +  YY  ++A NS G GP S  V   T K 
Sbjct: 843  WNGGGKEESSSKMK-VAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKT 901

Query: 1055 DSSDKMPN 1062
              S    N
Sbjct: 902  PPSQPPGN 909


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  218 bits (555), Expect = 3e-56
 Identities = 224/828 (27%), Positives = 342/828 (41%), Gaps = 103/828 (12%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 35  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 95  HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153

Query: 175 -VNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---P 264

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQA---QPEFLKQPTNI 350
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ     P F+ +P + 
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324

Query: 351 YAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVK 402
                  + F+CE TG P P + W + G   +   Y        F + +  +L +  + +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384

Query: 403 SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRT 461
           SD G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVAT 443

Query: 462 PASDPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQN 517
            +  P       ++ + K+G+       R++   + G +Q+    L     Y    +A  
Sbjct: 444 GSPVP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIAST 493

Query: 518 KHGSGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNG 567
             G    SA + V E    VQ P P  PNL   A         S  ++T++W+  ++   
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553

Query: 568 EIQNYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV 624
              +Y +      +         +V + +  I GLK    Y F V A N +  G+S P  
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQ 611

Query: 625 ---AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQI 666
               V+T   +P++             N  L + N     S SI +HW       Q+  I
Sbjct: 612 ISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYI 668

Query: 667 TGYKIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722
            GYKI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE 728

Query: 723 WLSAETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAI 773
              A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y +
Sbjct: 729 IKFAKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779

Query: 774 GYGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
            + +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826



 Score =  145 bits (367), Expect = 2e-34
 Identities = 218/896 (24%), Positives = 341/896 (38%), Gaps = 152/896 (16%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141

Query: 260 RVIGQDVVLPCVAS-GLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
             +G+  V+ C    G P PTI W K+   LD +  ER+ +  GG L I+   + DAG Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKSDAGKY 199

Query: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L +     +    
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPH 316

Query: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 371

Query: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 372 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426

Query: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 485

Query: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 486 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 535

Query: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 536 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 590

Query: 702 GTEYNFRVAALTINGTG---------------PATDWLSAETFESDLDETRV----PEVP 742
              Y F V A    G                 P +  +  +  + +L    +    P V 
Sbjct: 591 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 650

Query: 743 SSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTI 796
           SS       +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I
Sbjct: 651 SS-------SSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 702

Query: 797 ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
            +L    +Y I  + F N  +G               SE+        +    +  P  P
Sbjct: 703 PDLRKGVNYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAP 742

Query: 857 PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL 916
           P GV  S    +   I  +    P+  +    + Y V    N       K  + +T S +
Sbjct: 743 PQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVV 802

Query: 917 VTGLKPNTLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
           +  L P   Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 803 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 853



 Score =  120 bits (302), Expect = 7e-27
 Identities = 189/864 (21%), Positives = 328/864 (37%), Gaps = 95/864 (10%)

Query: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 32   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 92   RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151

Query: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 152  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211

Query: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 212  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259

Query: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+   E   
Sbjct: 260  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPH 316

Query: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
                P  +  A   T   VT++   +GN +          QN    Y    +     V  
Sbjct: 317  FVVKPRDQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373

Query: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 374  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 430  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 483

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543

Query: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 544  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602

Query: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 603  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 650

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 651  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 709

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 710  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 769

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 770  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826

Query: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
             SE  QF    A  +   P DQ S
Sbjct: 827  KSEP-QFIQLDAHGNPVSPEDQVS 849



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 147/633 (23%), Positives = 218/633 (34%), Gaps = 95/633 (15%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281

Query: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV---AGLPRFTSQPEPSSVYAGNNAIL 171
                   D G Y CVA  E++      +A L V   +  P F  +P    V  G     
Sbjct: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334

Query: 172 NCEVNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVV 223
            CE   +  P + W +        + QP     R     +G L I+N    D G Y C  
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394

Query: 224 ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGL 275
            +         +    L   +VI+D     +P P++R         +    VL CVA+G 
Sbjct: 395 LNVA----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 276 PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQA 333
           P PTI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  
Sbjct: 446 PVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 504

Query: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKE 392
           E+     P    +PT+     S     E     + T T+ W  N      P+ Y      
Sbjct: 505 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 564

Query: 393 HNLQVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDV 445
           H         +    +Q +AEN      A          L ++  A A     PS   D 
Sbjct: 565 H---------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 615

Query: 446 V------------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTY 473
           V                               +++S+  I++ W       +  G  + Y
Sbjct: 616 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILY 675

Query: 474 SVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQ 533
                  G +   V     P +  V I +L     Y  +         G  S     +T 
Sbjct: 676 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 735

Query: 534 PEV-QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVD 588
            E    P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD
Sbjct: 736 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 795

Query: 589 VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S+ S  I  L     YS  V A    G GV +
Sbjct: 796 GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  218 bits (555), Expect = 3e-56
 Identities = 224/828 (27%), Positives = 342/828 (41%), Gaps = 103/828 (12%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 35  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 95  HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153

Query: 175 -VNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---P 264

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQA---QPEFLKQPTNI 350
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ     P F+ +P + 
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324

Query: 351 YAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVK 402
                  + F+CE TG P P + W + G   +   Y        F + +  +L +  + +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384

Query: 403 SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRT 461
           SD G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVAT 443

Query: 462 PASDPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQN 517
            +  P       ++ + K+G+       R++   + G +Q+    L     Y    +A  
Sbjct: 444 GSPVP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIAST 493

Query: 518 KHGSGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNG 567
             G    SA + V E    VQ P P  PNL   A         S  ++T++W+  ++   
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553

Query: 568 EIQNYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV 624
              +Y +      +         +V + +  I GLK    Y F V A N +  G+S P  
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQ 611

Query: 625 ---AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQI 666
               V+T   +P++             N  L + N     S SI +HW       Q+  I
Sbjct: 612 ISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYI 668

Query: 667 TGYKIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722
            GYKI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE 728

Query: 723 WLSAETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAI 773
              A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y +
Sbjct: 729 IKFAKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779

Query: 774 GYGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
            + +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826



 Score =  145 bits (367), Expect = 2e-34
 Identities = 218/896 (24%), Positives = 341/896 (38%), Gaps = 152/896 (16%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141

Query: 260 RVIGQDVVLPCVAS-GLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
             +G+  V+ C    G P PTI W K+   LD +  ER+ +  GG L I+   + DAG Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKSDAGKY 199

Query: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L +     +    
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPH 316

Query: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 371

Query: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 372 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426

Query: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 485

Query: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 486 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 535

Query: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 536 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 590

Query: 702 GTEYNFRVAALTINGTG---------------PATDWLSAETFESDLDETRV----PEVP 742
              Y F V A    G                 P +  +  +  + +L    +    P V 
Sbjct: 591 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 650

Query: 743 SSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTI 796
           SS       +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I
Sbjct: 651 SS-------SSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 702

Query: 797 ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
            +L    +Y I  + F N  +G               SE+        +    +  P  P
Sbjct: 703 PDLRKGVNYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAP 742

Query: 857 PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL 916
           P GV  S    +   I  +    P+  +    + Y V    N       K  + +T S +
Sbjct: 743 PQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVV 802

Query: 917 VTGLKPNTLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
           +  L P   Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 803 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 853



 Score =  120 bits (302), Expect = 7e-27
 Identities = 189/864 (21%), Positives = 328/864 (37%), Gaps = 95/864 (10%)

Query: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 32   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 92   RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151

Query: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 152  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211

Query: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 212  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259

Query: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+   E   
Sbjct: 260  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPH 316

Query: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
                P  +  A   T   VT++   +GN +          QN    Y    +     V  
Sbjct: 317  FVVKPRDQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373

Query: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 374  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 430  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 483

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543

Query: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 544  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602

Query: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 603  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 650

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 651  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 709

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 710  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 769

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 770  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826

Query: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
             SE  QF    A  +   P DQ S
Sbjct: 827  KSEP-QFIQLDAHGNPVSPEDQVS 849



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 147/633 (23%), Positives = 218/633 (34%), Gaps = 95/633 (15%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281

Query: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV---AGLPRFTSQPEPSSVYAGNNAIL 171
                   D G Y CVA  E++      +A L V   +  P F  +P    V  G     
Sbjct: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334

Query: 172 NCEVNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVV 223
            CE   +  P + W +        + QP     R     +G L I+N    D G Y C  
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394

Query: 224 ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGL 275
            +         +    L   +VI+D     +P P++R         +    VL CVA+G 
Sbjct: 395 LNVA----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 276 PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQA 333
           P PTI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  
Sbjct: 446 PVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 504

Query: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKE 392
           E+     P    +PT+     S     E     + T T+ W  N      P+ Y      
Sbjct: 505 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 564

Query: 393 HNLQVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDV 445
           H         +    +Q +AEN      A          L ++  A A     PS   D 
Sbjct: 565 H---------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 615

Query: 446 V------------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTY 473
           V                               +++S+  I++ W       +  G  + Y
Sbjct: 616 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILY 675

Query: 474 SVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQ 533
                  G +   V     P +  V I +L     Y  +         G  S     +T 
Sbjct: 676 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 735

Query: 534 PEV-QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVD 588
            E    P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD
Sbjct: 736 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 795

Query: 589 VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S+ S  I  L     YS  V A    G GV +
Sbjct: 796 GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  218 bits (555), Expect = 3e-56
 Identities = 224/828 (27%), Positives = 342/828 (41%), Gaps = 103/828 (12%)

Query: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 35  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94

Query: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 95  HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153

Query: 175 -VNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213

Query: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---P 264

Query: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQA---QPEFLKQPTNI 350
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ     P F+ +P + 
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324

Query: 351 YAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVK 402
                  + F+CE TG P P + W + G   +   Y        F + +  +L +  + +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384

Query: 403 SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRT 461
           SD G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVAT 443

Query: 462 PASDPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQN 517
            +  P       ++ + K+G+       R++   + G +Q+    L     Y    +A  
Sbjct: 444 GSPVP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIAST 493

Query: 518 KHGSGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNG 567
             G    SA + V E    VQ P P  PNL   A         S  ++T++W+  ++   
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553

Query: 568 EIQNYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV 624
              +Y +      +         +V + +  I GLK    Y F V A N +  G+S P  
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQ 611

Query: 625 ---AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQI 666
               V+T   +P++             N  L + N     S SI +HW       Q+  I
Sbjct: 612 ISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYI 668

Query: 667 TGYKIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722
            GYKI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE 728

Query: 723 WLSAETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAI 773
              A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y +
Sbjct: 729 IKFAKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779

Query: 774 GYGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
            + +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826



 Score =  145 bits (367), Expect = 2e-34
 Identities = 218/896 (24%), Positives = 341/896 (38%), Gaps = 152/896 (16%)

Query: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141

Query: 260 RVIGQDVVLPCVAS-GLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
             +G+  V+ C    G P PTI W K+   LD +  ER+ +  GG L I+   + DAG Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKSDAGKY 199

Query: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259

Query: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L +     +    
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPH 316

Query: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 371

Query: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 372 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426

Query: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 485

Query: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 486 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 535

Query: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 536 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 590

Query: 702 GTEYNFRVAALTINGTG---------------PATDWLSAETFESDLDETRV----PEVP 742
              Y F V A    G                 P +  +  +  + +L    +    P V 
Sbjct: 591 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 650

Query: 743 SSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTI 796
           SS       +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I
Sbjct: 651 SS-------SSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 702

Query: 797 ENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP 856
            +L    +Y I  + F N  +G               SE+        +    +  P  P
Sbjct: 703 PDLRKGVNYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAP 742

Query: 857 PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL 916
           P GV  S    +   I  +    P+  +    + Y V    N       K  + +T S +
Sbjct: 743 PQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVV 802

Query: 917 VTGLKPNTLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
           +  L P   Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 803 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 853



 Score =  120 bits (302), Expect = 7e-27
 Identities = 189/864 (21%), Positives = 328/864 (37%), Gaps = 95/864 (10%)

Query: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 32   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 92   RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151

Query: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 152  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211

Query: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 212  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259

Query: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+   E   
Sbjct: 260  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPH 316

Query: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
                P  +  A   T   VT++   +GN +          QN    Y    +     V  
Sbjct: 317  FVVKPRDQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373

Query: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 374  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 430  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 483

Query: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543

Query: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 544  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602

Query: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 603  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 650

Query: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 651  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 709

Query: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 710  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 769

Query: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 770  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826

Query: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
             SE  QF    A  +   P DQ S
Sbjct: 827  KSEP-QFIQLDAHGNPVSPEDQVS 849



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 147/633 (23%), Positives = 218/633 (34%), Gaps = 95/633 (15%)

Query: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281

Query: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV---AGLPRFTSQPEPSSVYAGNNAIL 171
                   D G Y CVA  E++      +A L V   +  P F  +P    V  G     
Sbjct: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334

Query: 172 NCEVNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVV 223
            CE   +  P + W +        + QP     R     +G L I+N    D G Y C  
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394

Query: 224 ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGL 275
            +         +    L   +VI+D     +P P++R         +    VL CVA+G 
Sbjct: 395 LNVA----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 276 PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQA 333
           P PTI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  
Sbjct: 446 PVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 504

Query: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKE 392
           E+     P    +PT+     S     E     + T T+ W  N      P+ Y      
Sbjct: 505 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 564

Query: 393 HNLQVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDV 445
           H         +    +Q +AEN      A          L ++  A A     PS   D 
Sbjct: 565 H---------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 615

Query: 446 V------------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTY 473
           V                               +++S+  I++ W       +  G  + Y
Sbjct: 616 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILY 675

Query: 474 SVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQ 533
                  G +   V     P +  V I +L     Y  +         G  S     +T 
Sbjct: 676 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 735

Query: 534 PEV-QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVD 588
            E    P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD
Sbjct: 736 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 795

Query: 589 VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
            S+ S  I  L     YS  V A    G GV +
Sbjct: 796 GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,201,766
Number of Sequences: 37866
Number of extensions: 3365661
Number of successful extensions: 23226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 284
Number of HSP's successfully gapped in prelim test: 517
Number of HSP's that attempted gapping in prelim test: 11022
Number of HSP's gapped (non-prelim): 5250
length of query: 1461
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1346
effective length of database: 13,892,928
effective search space: 18699881088
effective search space used: 18699881088
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.