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Search of human proteins with 157277988
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
(809 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 1641 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 1309 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 977 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 977 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 977 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 965 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 947 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 928 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 928 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 920 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 887 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 828 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 744 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 247 3e-65
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 247 3e-65
gi|4826894 phosphodiesterase 1C [Homo sapiens] 239 6e-63
gi|4505677 phosphodiesterase 1B [Homo sapiens] 234 3e-61
gi|9506959 phosphodiesterase 7B [Homo sapiens] 228 1e-59
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 218 2e-56
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 218 2e-56
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 208 2e-53
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 208 2e-53
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 208 2e-53
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 208 2e-53
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 208 2e-53
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 208 2e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 192 8e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 188 2e-47
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 177 3e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 3e-44
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 1641 bits (4249), Expect = 0.0
Identities = 809/809 (100%), Positives = 809/809 (100%)
Query: 1 MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP 60
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
Sbjct: 1 MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP 60
Query: 61 PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA 120
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
Sbjct: 61 PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA 120
Query: 121 MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA 180
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
Sbjct: 121 MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA 180
Query: 181 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF 240
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
Sbjct: 181 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF 240
Query: 241 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 300
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
Sbjct: 241 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 300
Query: 301 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 360
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
Sbjct: 301 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 360
Query: 361 MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL 420
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
Sbjct: 361 MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL 420
Query: 421 TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST 480
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
Sbjct: 421 TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST 480
Query: 481 PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 540
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
Sbjct: 481 PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 540
Query: 541 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL 600
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
Sbjct: 541 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL 600
Query: 601 LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC 660
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
Sbjct: 601 LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC 660
Query: 661 DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP 720
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
Sbjct: 661 DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP 720
Query: 721 DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL 780
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
Sbjct: 721 DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL 780
Query: 781 DEQVEEEAVGEEEESQPEACVIDDRSPDT 809
DEQVEEEAVGEEEESQPEACVIDDRSPDT
Sbjct: 781 DEQVEEEAVGEEEESQPEACVIDDRSPDT 809
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 1309 bits (3388), Expect = 0.0
Identities = 657/657 (100%), Positives = 657/657 (100%)
Query: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 212
FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI
Sbjct: 17 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 76
Query: 213 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 272
ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA
Sbjct: 77 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 136
Query: 273 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 332
YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF
Sbjct: 137 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 196
Query: 333 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 392
ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED
Sbjct: 197 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 256
Query: 393 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 452
VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE
Sbjct: 257 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 316
Query: 453 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 512
DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ
Sbjct: 317 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 376
Query: 513 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA
Sbjct: 377 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 632
TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR
Sbjct: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 496
Query: 633 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 692
QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP
Sbjct: 497 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 556
Query: 693 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 752
DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS
Sbjct: 557 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 616
Query: 753 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 809
GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
Sbjct: 617 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 673
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 977 bits (2526), Expect = 0.0
Identities = 495/628 (78%), Positives = 547/628 (87%), Gaps = 8/628 (1%)
Query: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNSS 211
FDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNSS
Sbjct: 95 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
Query: 212 IASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEE 271
+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ EE
Sbjct: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQEE 213
Query: 272 AYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 331
+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE
Sbjct: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
Query: 332 FISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKTE 389
+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV TE
Sbjct: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
Query: 390 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLM 449
ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+M
Sbjct: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
Query: 450 TLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509
TLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPGV
Sbjct: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
Query: 510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI 569
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID+
Sbjct: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
Query: 570 VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ 629
VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L+
Sbjct: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
Query: 630 LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 689
LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
Query: 690 VHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTE 749
V PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+ E
Sbjct: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
Query: 750 KDSGSQVEEDTSCSDSKTLCTQDSESTE 777
K+ E + S +KTLC D E+ +
Sbjct: 694 KEG----EGHSYFSSTKTLCVIDPENRD 717
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 977 bits (2526), Expect = 0.0
Identities = 495/628 (78%), Positives = 547/628 (87%), Gaps = 8/628 (1%)
Query: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNSS 211
FDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNSS
Sbjct: 80 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 139
Query: 212 IASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEE 271
+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ EE
Sbjct: 140 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQEE 198
Query: 272 AYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 331
+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE
Sbjct: 199 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 258
Query: 332 FISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKTE 389
+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV TE
Sbjct: 259 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 318
Query: 390 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLM 449
ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+M
Sbjct: 319 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 378
Query: 450 TLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509
TLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPGV
Sbjct: 379 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 438
Query: 510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI 569
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID+
Sbjct: 439 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 498
Query: 570 VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ 629
VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L+
Sbjct: 499 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 558
Query: 630 LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 689
LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 559 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 618
Query: 690 VHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTE 749
V PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+ E
Sbjct: 619 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 678
Query: 750 KDSGSQVEEDTSCSDSKTLCTQDSESTE 777
K+ E + S +KTLC D E+ +
Sbjct: 679 KEG----EGHSYFSSTKTLCVIDPENRD 702
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 977 bits (2526), Expect = 0.0
Identities = 495/628 (78%), Positives = 547/628 (87%), Gaps = 8/628 (1%)
Query: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNSS 211
FDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNSS
Sbjct: 95 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
Query: 212 IASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEE 271
+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ EE
Sbjct: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQEE 213
Query: 272 AYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 331
+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE
Sbjct: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
Query: 332 FISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKTE 389
+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV TE
Sbjct: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
Query: 390 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLM 449
ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+M
Sbjct: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
Query: 450 TLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509
TLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPGV
Sbjct: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
Query: 510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI 569
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID+
Sbjct: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
Query: 570 VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ 629
VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L+
Sbjct: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
Query: 630 LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 689
LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
Query: 690 VHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTE 749
V PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+ E
Sbjct: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
Query: 750 KDSGSQVEEDTSCSDSKTLCTQDSESTE 777
K+ E + S +KTLC D E+ +
Sbjct: 694 KEG----EGHSYFSSTKTLCVIDPENRD 717
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 965 bits (2494), Expect = 0.0
Identities = 518/786 (65%), Positives = 606/786 (77%), Gaps = 76/786 (9%)
Query: 57 LPPPPPPSPQ------PQP---QCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHR 107
+ PP PS + P P Q L+PPP P P R++ R
Sbjct: 1 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPI--------------RIQQR 46
Query: 108 GYSDT------ERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGL----------- 150
GYSD+ ER + R ++R A++T RPGL+ +RMSWPSSF G
Sbjct: 47 GYSDSAERAERERQPH-RPIERAD-AMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGS 104
Query: 151 -RRFDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMS 207
RRF+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MS
Sbjct: 105 SRRFEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 162
Query: 208 RNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKA 266
RNSS+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KA
Sbjct: 163 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKA 220
Query: 267 TITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSG 326
T++EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSG
Sbjct: 221 TLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280
Query: 327 NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKK 369
NQVSE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KK
Sbjct: 281 NQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKK 340
Query: 370 LMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ 429
LMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQ
Sbjct: 341 LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ 400
Query: 430 ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD 489
ERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTD
Sbjct: 401 ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTD 460
Query: 490 LEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD 549
LEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCD
Sbjct: 461 LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCD 520
Query: 550 IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRI 609
IFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRI
Sbjct: 521 IFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI 580
Query: 610 QVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK 669
QVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEK
Sbjct: 581 QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK 640
Query: 670 SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GR 727
SQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 641 SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGH 700
Query: 728 QGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEE 787
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + E
Sbjct: 701 PPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWE 753
Query: 788 AVGEEE 793
A +E
Sbjct: 754 ASPAQE 759
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 947 bits (2447), Expect = 0.0
Identities = 485/686 (70%), Positives = 561/686 (81%), Gaps = 21/686 (3%)
Query: 103 RVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAG 162
R++ R YSD ++ CR D + RP L+KSR+SWP S RRFD++NG S G
Sbjct: 41 RIQQRFYSDPDKSAGCRERDLSP-------RPELRKSRLSWPVS--SCRRFDLENGLSCG 91
Query: 163 RSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLI 222
R LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+I
Sbjct: 92 RRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMI 151
Query: 223 VTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLE 282
VTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+
Sbjct: 152 VTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLD 211
Query: 283 ELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQH 342
ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q
Sbjct: 212 ELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQT 271
Query: 343 EVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN 402
EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED N
Sbjct: 272 EVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTN 328
Query: 403 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 462
KWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYH
Sbjct: 329 KWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYH 388
Query: 463 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA 522
N++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELA
Sbjct: 389 NSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELA 448
Query: 523 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL 582
LMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLL
Sbjct: 449 LMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLL 508
Query: 583 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF 642
ADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EF
Sbjct: 509 ADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEF 568
Query: 643 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE 702
F+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLE
Sbjct: 569 FQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLE 628
Query: 703 DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEE 758
DNREWYQS IP+SPS + +G ++FQFELTLEE E D E++ + +E
Sbjct: 629 DNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKE 684
Query: 759 DTSCSDSKTLCTQ-DSESTEIPLDEQ 783
D++ L + + ++PLD Q
Sbjct: 685 ALELPDTELLSPEAGPDPGDLPLDNQ 710
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 153 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 210
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 47 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 104
Query: 211 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 269
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 105 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 162
Query: 270 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 329
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 163 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 222
Query: 330 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 372
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 223 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 282
Query: 373 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 432
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 283 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 342
Query: 433 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 492
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 343 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 402
Query: 493 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 552
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 403 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 462
Query: 553 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 463 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 522
Query: 613 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 672
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 523 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 582
Query: 673 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 730
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 583 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 642
Query: 731 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 790
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 643 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 695
Query: 791 EEE 793
+E
Sbjct: 696 AQE 698
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 153 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 210
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 82 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 139
Query: 211 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 269
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 140 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 197
Query: 270 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 329
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 198 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 257
Query: 330 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 372
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 258 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 317
Query: 373 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 432
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 318 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 377
Query: 433 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 492
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 378 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 437
Query: 493 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 552
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 438 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 497
Query: 553 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 498 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 557
Query: 613 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 672
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 558 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 617
Query: 673 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 730
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 618 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 677
Query: 731 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 790
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 678 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 730
Query: 791 EEE 793
+E
Sbjct: 731 AQE 733
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 920 bits (2377), Expect = 0.0
Identities = 479/710 (67%), Positives = 560/710 (78%), Gaps = 40/710 (5%)
Query: 79 PPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKK 138
PP P P P PG+ RG + G+ G L+ + + S ++ ++
Sbjct: 4 PPAPAPVPGPGSPRG--SPRGSPG-------------LFRKLLVNQSIRLQ-------RR 41
Query: 139 SRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSD 198
++ P F D++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSD
Sbjct: 42 FTVAHPLCF------DLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSD 95
Query: 199 YDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMC 258
Y+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+
Sbjct: 96 YELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVG 155
Query: 259 NQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTH 318
N S N+ E+ QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTH
Sbjct: 156 NPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTH 215
Query: 319 LSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTN 378
LSE SRSGNQVSE+IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL++
Sbjct: 216 LSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSS 272
Query: 379 SSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFK 438
+++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+
Sbjct: 273 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 332
Query: 439 IPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFA 498
IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FA
Sbjct: 333 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 392
Query: 499 SAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQ 558
SAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQ
Sbjct: 393 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 452
Query: 559 RQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHC 618
R SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHC
Sbjct: 453 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 512
Query: 619 ADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 678
ADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI
Sbjct: 513 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 572
Query: 679 VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFEL 738
HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFEL
Sbjct: 573 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFEL 628
Query: 739 TLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 783
TLEE E D E++ + +E D++ L + + ++PLD Q
Sbjct: 629 TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 678
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 887 bits (2292), Expect = 0.0
Identities = 450/611 (73%), Positives = 516/611 (84%), Gaps = 12/611 (1%)
Query: 178 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 237
+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 238 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 297
+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+ELDWCLDQLETLQTR
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 298 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 357
HSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q EVE+P T +E +
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ- 179
Query: 358 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 417
PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGN
Sbjct: 180 --PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGN 237
Query: 418 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 477
RPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVL
Sbjct: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
Query: 478 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 537
L+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLA
Sbjct: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
Query: 538 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 597
VGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS
Sbjct: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
Query: 598 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 657
GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++IS
Sbjct: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
Query: 658 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 717
PMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS
Sbjct: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS 537
Query: 718 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-D 772
+ +G ++FQFELTLEE E D E++ + +E D++ L +
Sbjct: 538 DLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAG 593
Query: 773 SESTEIPLDEQ 783
+ ++PLD Q
Sbjct: 594 PDPGDLPLDNQ 604
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 828 bits (2138), Expect = 0.0
Identities = 421/539 (78%), Positives = 465/539 (86%), Gaps = 15/539 (2%)
Query: 241 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 300
+A+ +LQ P+ P+C EE+YQKLA ETLEELDWCLDQLET+QT SV
Sbjct: 20 SAMDSLQPLQPNYM-PVC--------LFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
Query: 301 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 360
SEMASNKFKRMLNRELTHLSEMSRSGNQVSE+ISNTFLDKQ++VEIPSPTQK++EKKK+
Sbjct: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
Query: 361 --MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNR 418
M+QISGVKKLMHSSSL N+SI RFGV TE ED LAKELED+NKWGL++F +A S NR
Sbjct: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
Query: 419 PLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL 478
PLT IM+ IFQERDLLKTF+I DT ITY+MTLEDHYH+DVAYHN++HAADV QSTHVLL
Sbjct: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
Query: 479 STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAV 538
STPAL+AVFTDLEILAAIFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAV
Sbjct: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
Query: 539 GFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSG 598
GFKLLQEE+CDIF NLTKKQRQ+LRKMVID+VLATDMSKHM+LLADLKTMVETKKVTSSG
Sbjct: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
Query: 599 VLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISP 658
VLLLDNY+DRIQVL+NMVHCADLSNPTK L+LYRQWTDRIMEEFF+QGD+ERERGMEISP
Sbjct: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
Query: 659 MCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSP 718
MCDKH ASVEKSQVGFIDYIVHPLWETWADLV PDAQDILDTLEDNR WYQS IPQSPSP
Sbjct: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
Query: 719 APDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 777
D+ QG EKFQFELTL+E+ EK+ E + S +KTLC D E+ +
Sbjct: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEG----EGHSYFSSTKTLCVIDPENRD 545
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 744 bits (1921), Expect = 0.0
Identities = 375/507 (73%), Positives = 432/507 (85%), Gaps = 26/507 (5%)
Query: 306 NKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK------- 358
++FKRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 359 ----------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHV 408
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 409 FRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAA 468
F +++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 469 DVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS 528
DV+QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 529 SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTM 588
SVLENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 589 VETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDR 648
VETKKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDR
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 649 ERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 708
ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 709 QSTIPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK 766
S I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ +
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQE 493
Query: 767 TLCTQDSESTEIPLDEQVEEEAVGEEE 793
L Q E LD + EA +E
Sbjct: 494 ALTAQGLSGVEEALDATIAWEASPAQE 520
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 247 bits (631), Expect = 3e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 309 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 366
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
Query: 367 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 426
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
Query: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 485
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 486 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 545
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
Query: 546 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 605
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
Query: 606 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 665
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
Query: 666 SVEKSQVGFIDYIVHPLWETWAD 688
V +SQ+GFID+IV P + D
Sbjct: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 247 bits (631), Expect = 3e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 309 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 366
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
Query: 367 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 426
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
Query: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 485
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 486 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 545
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
Query: 546 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 605
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
Query: 606 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 665
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
Query: 666 SVEKSQVGFIDYIVHPLWETWAD 688
V +SQ+GFID+IV P + D
Sbjct: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 239 bits (611), Expect = 6e-63
Identities = 142/415 (34%), Positives = 219/415 (52%), Gaps = 29/415 (6%)
Query: 398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 457
L+DV+KW VF + E SG+ L I + + DL+ FKIP+ L++++ LE Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 458 DV-AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
YHN +HAADV Q+ H LL + T+LEI A IF++AIHD +H G +N F I
Sbjct: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
Query: 517 TNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLATDM 575
T S+ A++YND SVLENHHL+ ++LLQ +E +I NL+K + R +VI++V+ATDM
Sbjct: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
Query: 576 SKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWT 635
S H + +KT ++ + ++ + L M+H AD+S+P K L+ +WT
Sbjct: 343 SCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRWT 391
Query: 636 DRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQ 695
++EEFFRQGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 392 MSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVS 451
Query: 696 DILDTLED-----NREWYQSTIPQSPSPAPDDPEEGRQG---------QTEKFQFELTLE 741
++D R ++I S + G +G + F+ T
Sbjct: 452 PLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWT 511
Query: 742 EDGESDTEKDSGSQVEEDTSC--SDSKTLCTQDSESTEIPLDEQVEEEAVGEEEE 794
E + E+ +E+ + ++ K + + E+ Q EE A G+ E+
Sbjct: 512 EVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEK 566
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 234 bits (596), Expect = 3e-61
Identities = 127/333 (38%), Positives = 196/333 (58%), Gaps = 22/333 (6%)
Query: 398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 457
L++++ W VF + + + + L I+ + +L+ FKIP L+++L LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 458 -DVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
YHN IHAADV Q+ H L + +++E+LA IFA+AIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 517 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 576
T SE A++YND SVLENHH++ F+L+Q++ +IF NLTK + LR +VI++VLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 577 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 636
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 637 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD 696
+MEEFFRQGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 697 ILDTLEDNR-------EWYQSTIP-QSPSPAPD 721
+ D ED++ +W Q ++ + P PD
Sbjct: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPD 477
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 228 bits (582), Expect = 1e-59
Identities = 128/400 (32%), Positives = 215/400 (53%), Gaps = 27/400 (6%)
Query: 358 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNKWGLHVFRIAEL 414
K+ + ++ ++ H+S L IP+ + ED L + L V W +F L
Sbjct: 66 KKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRL 125
Query: 415 SGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQST 474
+ L ++ +F L+ FK+ + TL +L+ +++ YH+ YHN +HAADV Q+
Sbjct: 126 TNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAM 185
Query: 475 HVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 534
H L P L + T L+I+ + A+A HDVDHPGV+ FLI TN LA +Y + SVLENH
Sbjct: 186 HCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENH 245
Query: 535 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 594
H +L+E + +L K+ Q + + + ++LATD+++ L LK + K
Sbjct: 246 HWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD- 302
Query: 595 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 654
L L++ DR +LQ + CAD+ NP + ++ +QW++R+ EEF+RQG+ E++ +
Sbjct: 303 -----LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFEL 357
Query: 655 EISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNREWYQSTI 712
EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ ++S +
Sbjct: 358 EISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL 417
Query: 713 PQ------SPSPAPDDPEEGRQGQTEKFQFELTLEEDGES 746
P+ S PD G+ ++E E++G+S
Sbjct: 418 PRQHRSRGSSGSGPDHDHAGQGTESE--------EQEGDS 449
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 218 bits (555), Expect = 2e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 573 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 621
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 622 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 680
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 681 PLWETWADLVHPDAQDILDTLEDNREWYQ 709
+++ W V D D++ L++N ++++
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 768
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 218 bits (555), Expect = 2e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 573 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 621
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 622 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 680
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 681 PLWETWADLVHPDAQDILDTLEDNREWYQ 709
+++ W V D D++ L++N ++++
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 680 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 737
Query: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 738 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 797
Query: 683 WETWADLVHPDAQDILDTLEDN-REW 707
++ W H A ++ L DN + W
Sbjct: 798 FDAWDAFAHLPA--LMQHLADNYKHW 821
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 707 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 764
Query: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 765 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 824
Query: 683 WETWADLVHPDAQDILDTLEDN-REW 707
++ W H A ++ L DN + W
Sbjct: 825 FDAWDAFAHLPA--LMQHLADNYKHW 848
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 672 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 729
Query: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 730 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 789
Query: 683 WETWADLVHPDAQDILDTLEDN-REW 707
++ W H A ++ L DN + W
Sbjct: 790 FDAWDAFAHLPA--LMQHLADNYKHW 813
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 630 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 687
Query: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 688 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 747
Query: 683 WETWADLVHPDAQDILDTLEDN-REW 707
++ W H A ++ L DN + W
Sbjct: 748 FDAWDAFAHLPA--LMQHLADNYKHW 771
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 727 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 784
Query: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 785 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 844
Query: 683 WETWADLVHPDAQDILDTLEDN-REW 707
++ W H A ++ L DN + W
Sbjct: 845 FDAWDAFAHLPA--LMQHLADNYKHW 868
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 208 bits (529), Expect = 2e-53
Identities = 126/411 (30%), Positives = 215/411 (52%), Gaps = 19/411 (4%)
Query: 284 LDWCLDQLE----TLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLD 339
L WCL + T + R ++S +S++ + R L + SR+G + S+ ++D
Sbjct: 5 LIWCLALVLIKWITSKRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYID 63
Query: 340 KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE-- 397
+ S ++ E R + ++ ++ + SS + + +D +
Sbjct: 64 FRI---FHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
Query: 398 -LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYH 456
LE V W +F L+ L + +F L++ F + + L +L+ +++ YH
Sbjct: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
Query: 457 ADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
+ YHN +HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI
Sbjct: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 517 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 576
TN LA +Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS 298
Query: 577 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 636
+ L+ ++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++
Sbjct: 299 RQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSE 352
Query: 637 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA 687
++ EEFF QGD E++ + +SP+CD+H S+ Q+GF+ Y+V PL+ WA
Sbjct: 353 KVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 192 bits (489), Expect = 8e-49
Identities = 117/395 (29%), Positives = 204/395 (51%), Gaps = 15/395 (3%)
Query: 287 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 346
C + + Q R ++S +S++ + R L + SR+G + S+ ++D +
Sbjct: 38 CPNPRQLSQRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYIDFRI---F 93
Query: 347 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNK 403
S ++ E R + ++ ++ + SS + + +D + LE V
Sbjct: 94 HSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGN 153
Query: 404 WGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHN 463
W +F L+ L + +F L++ F + + L +L+ +++ YH+ YHN
Sbjct: 154 WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHN 213
Query: 464 NIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELAL 523
+HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI TN LA
Sbjct: 214 AVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLAT 273
Query: 524 MYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 583
+Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S+ L+
Sbjct: 274 LYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLS 331
Query: 584 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 643
++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++++ EEFF
Sbjct: 332 LFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
Query: 644 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 678
QGD E++ + +SP+CD+H S+ Q+G Y+
Sbjct: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 188 bits (477), Expect = 2e-47
Identities = 158/568 (27%), Positives = 254/568 (44%), Gaps = 98/568 (17%)
Query: 295 QTRHSVSEMASNKFKRMLNRELTHLSE-----MSRSGNQVSEFISNTFLDKQHEVEIPSP 349
Q R+S S + ++ +ML T S+ +SG + + F +F K E +
Sbjct: 567 QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESF--KLMETQQEEE 624
Query: 350 TQKEKEKKKRPMSQISGVKKLMHSSSLTN--SSIPRFGVKTEQEDVLAKELEDVNKWGLH 407
T+K K+ +K + + S TN + + E+ D L +E ++ W
Sbjct: 625 TEK-KDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMSNWNFP 680
Query: 408 VFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN 464
+F + E G R L+ +M+T+FQ+ LL+ FKIP + Y LE+ Y D+ YHN
Sbjct: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DIPYHNR 739
Query: 465 IHAADVVQSTHVLLSTPA------------------------------------------ 482
IHA DV+ + L + P
Sbjct: 740 IHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESY 799
Query: 483 --LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 540
L + LE++A A+A+HD DHPG +N FL+ TN+ A++YND SVLENHH A +
Sbjct: 800 GCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAW 859
Query: 541 KL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV 599
L L + +L + + R +VI+ +LATD+ KH + LA+ + V S+G+
Sbjct: 860 NLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDVNSNGI 917
Query: 600 LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM 659
N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+ QGD E G+ ISP
Sbjct: 918 EW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPF 976
Query: 660 CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA 719
D+ + + K Q FI +IV PL ++ DA +L +W ++ +
Sbjct: 977 MDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP-----GQWLEA--EEDNDTE 1023
Query: 720 PDDPEEGRQGQTEKFQFELTLEEDGE----------------SDTEKDSGSQVEEDTSC- 762
D E+G + TE + E L ++ K VEE+ C
Sbjct: 1024 SGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCK 1083
Query: 763 SDSKTLCTQDS---ESTEIPLDEQVEEE 787
+D L ++S ++ EI + E+ +EE
Sbjct: 1084 ADGNKLQVENSSLPQADEIQVIEEADEE 1111
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 177 bits (450), Expect = 3e-44
Identities = 115/403 (28%), Positives = 207/403 (51%), Gaps = 28/403 (6%)
Query: 320 SEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNS 379
SE + N++ ++N + VE+ E EK K + ++ ++L SS TN
Sbjct: 30 SERAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMR--EELAARSSRTNC 87
Query: 380 SI------------PRFGVKTEQEDVLAKE-LEDVNKWGLHVFRIAELSGNRPLTVIMHT 426
PR V T + +L+ E +E + K F + N L+ + H
Sbjct: 88 PCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRK---PTFDVWLWEPNEMLSCLEH- 143
Query: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 486
++ + L++ F I TL +L + D+Y + +HN H V Q + ++ +L+
Sbjct: 144 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 202
Query: 487 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 546
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E
Sbjct: 203 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 262
Query: 547 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 606
C+IF N+ + +R+ +I ++LATDM++H ++ K +E ++ + L
Sbjct: 263 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL---- 318
Query: 607 DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS 666
+ ++ C D+SN +P+++ W D ++EE+F Q DRE+ G+ ++P D+ +
Sbjct: 319 ----LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 374
Query: 667 VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 709
+Q+GFI +++ P++ET L + +L L ++R+ Y+
Sbjct: 375 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 417
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (449), Expect = 3e-44
Identities = 98/328 (29%), Positives = 176/328 (53%), Gaps = 20/328 (6%)
Query: 382 PRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPV 441
P++ + E + L K DV W N L+ + H ++ + L++ F I
Sbjct: 37 PKYLLSPETIEALRKPTFDVWLW----------EPNEMLSCLEH-MYHDLGLVRDFSINP 85
Query: 442 DTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAI 501
TL +L + D+Y + +HN H V Q + ++ +L+ F+ +IL + A+
Sbjct: 86 VTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAIC 144
Query: 502 HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQS 561
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 145 HDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQ 204
Query: 562 LRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 621
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D+
Sbjct: 205 IRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCDI 256
Query: 622 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHP 681
SN +P+++ W D ++EE+F Q DRE+ G+ ++P D+ + +Q+GFI +++ P
Sbjct: 257 SNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIP 316
Query: 682 LWETWADLVHPDAQDILDTLEDNREWYQ 709
++ET L + +L L ++R+ Y+
Sbjct: 317 MFETVTKLFPMVEEIMLQPLWESRDRYE 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,128,585
Number of Sequences: 37866
Number of extensions: 2201784
Number of successful extensions: 63097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1151
Number of HSP's successfully gapped in prelim test: 731
Number of HSP's that attempted gapping in prelim test: 22451
Number of HSP's gapped (non-prelim): 20379
length of query: 809
length of database: 18,247,518
effective HSP length: 110
effective length of query: 699
effective length of database: 14,082,258
effective search space: 9843498342
effective search space used: 9843498342
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.