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Search of human proteins with 157266334
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266334 tubby like protein 1 [Homo sapiens]
(542 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266334 tubby like protein 1 [Homo sapiens] 1091 0.0
gi|19923167 tubby isoform a [Homo sapiens] 421 e-118
gi|29826279 tubby isoform b [Homo sapiens] 420 e-117
gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens] 365 e-101
gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens] 355 8e-98
gi|238859545 tubby like protein 2 [Homo sapiens] 302 4e-82
gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens] 73 8e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 72 1e-12
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 64 5e-10
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 61 3e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 60 4e-09
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 60 5e-09
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 60 5e-09
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 60 7e-09
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 60 7e-09
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 59 9e-09
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 59 1e-08
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 59 1e-08
gi|104526627 triadin [Homo sapiens] 59 1e-08
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 58 2e-08
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 58 2e-08
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 58 2e-08
gi|4557719 DNA ligase I [Homo sapiens] 58 3e-08
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 57 4e-08
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 57 4e-08
gi|217416343 fibrosin-like 1 [Homo sapiens] 56 7e-08
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 56 7e-08
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 56 7e-08
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 55 2e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 55 2e-07
>gi|157266334 tubby like protein 1 [Homo sapiens]
Length = 542
Score = 1091 bits (2821), Expect = 0.0
Identities = 542/542 (100%), Positives = 542/542 (100%)
Query: 1 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 60
MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
Sbjct: 1 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 60
Query: 61 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE 120
KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE
Sbjct: 61 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE 120
Query: 121 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR 180
EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR
Sbjct: 121 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR 180
Query: 181 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG 240
VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG
Sbjct: 181 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG 240
Query: 241 TPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP 300
TPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP
Sbjct: 241 TPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP 300
Query: 301 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS 360
QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS
Sbjct: 301 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS 360
Query: 361 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR 420
RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR
Sbjct: 361 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR 420
Query: 421 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ 480
MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ
Sbjct: 421 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ 480
Query: 481 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA 540
GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA
Sbjct: 481 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA 540
Query: 541 CE 542
CE
Sbjct: 541 CE 542
>gi|19923167 tubby isoform a [Homo sapiens]
Length = 561
Score = 421 bits (1083), Expect = e-118
Identities = 252/541 (46%), Positives = 321/541 (59%), Gaps = 70/541 (12%)
Query: 68 GRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDP-RETFLVARAPDAEDEEEEEEEDEE 126
G P S Q R P + RD +R +E +AR D DE + +
Sbjct: 25 GTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLD--DEGRNLRQQKL 82
Query: 127 DEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKA-----QGPRGD------------- 168
D + E+K+K ++PL +++AD + R +A Q P +
Sbjct: 83 DRQRALLEQKQK--KKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQV 140
Query: 169 ----------LGS--PDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPAS 215
LG+ P P R + G+G RK KK K G + S
Sbjct: 141 QEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKS 200
Query: 216 ARKSPAAMFLVGE-------------------GSPDKKALKKKGTPKGAR--KEEEEEEE 254
+ P + VG+ G + +++KG ++EE+EEE
Sbjct: 201 EAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEE 260
Query: 255 AATVIKKSNQKGKAKGKGKKKAKEERAPSPP---------VEVDEPREFVLRPAPQGRTV 305
++ + N + +K+ E A +P VEV + EF LRPAPQG T+
Sbjct: 261 NSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITI 320
Query: 306 RCRLTRDKKGMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGG 363
+CR+TRDKKGMDRGMYP+YFLHLD E KKVFLLAGRKRK+SKT+NYLIS+DPT+LSRGG
Sbjct: 321 KCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGG 380
Query: 364 ENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRM 421
+++IGKLRSNL+G +FTV+DNG NPQ+ S+ + S LRQELAAV YETNVLGF+GPR+M
Sbjct: 381 DSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKM 440
Query: 422 TVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQG 481
+VI+PGM+ +ERV IRPRN + LL RWQNK ES+IEL NK PVWNDD+ SY LNF G
Sbjct: 441 SVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHG 500
Query: 482 RVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLAC 541
RVTQASVKNFQI+H +DPDYIV+QFGRVAED FT+DY YPLCALQAFAIALSSFD KLAC
Sbjct: 501 RVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLAC 560
Query: 542 E 542
E
Sbjct: 561 E 561
>gi|29826279 tubby isoform b [Homo sapiens]
Length = 506
Score = 420 bits (1080), Expect = e-117
Identities = 223/406 (54%), Positives = 274/406 (67%), Gaps = 35/406 (8%)
Query: 172 PDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPASARKSPAAMFLVGE-- 228
P P R + G+G RK KK K G + S + P + VG+
Sbjct: 101 PTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSD 160
Query: 229 -----------------GSPDKKALKKKGTPKGAR--KEEEEEEEAATVIKKSNQKGKAK 269
G + +++KG ++EE+EEE ++ + N +
Sbjct: 161 HAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPS 220
Query: 270 GKGKKKAKEERAPSPP---------VEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGM 320
+K+ E A +P VEV + EF LRPAPQG T++CR+TRDKKGMDRGM
Sbjct: 221 SATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGM 280
Query: 321 YPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNR 378
YP+YFLHLD E KKVFLLAGRKRK+SKT+NYLIS+DPT+LSRGG+++IGKLRSNL+G +
Sbjct: 281 YPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTK 340
Query: 379 FTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVP 436
FTV+DNG NPQ+ S+ + S LRQELAAV YETNVLGF+GPR+M+VI+PGM+ +ERV
Sbjct: 341 FTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVS 400
Query: 437 IRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHA 496
IRPRN + LL RWQNK ES+IEL NK PVWNDD+ SY LNF GRVTQASVKNFQI+H
Sbjct: 401 IRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHG 460
Query: 497 DDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE 542
+DPDYIV+QFGRVAED FT+DY YPLCALQAFAIALSSFD KLACE
Sbjct: 461 NDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 506
Score = 30.4 bits (67), Expect = 4.3
Identities = 26/87 (29%), Positives = 35/87 (40%), Gaps = 18/87 (20%)
Query: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
+EDEEDEEE + + R S+ K R A P SP P +P+ V
Sbjct: 197 DEDEEDEEENSSSSSQL-----NSNTRPSSATSRKSVREAASAP-----SPTAPEQPVDV 246
Query: 182 RNKE--------APAGEGTKMRKTKKK 200
++ AP G K R T+ K
Sbjct: 247 EVQDLEEFALRPAPQGITIKCRITRDK 273
>gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens]
Length = 442
Score = 365 bits (937), Expect = e-101
Identities = 175/284 (61%), Positives = 223/284 (78%), Gaps = 3/284 (1%)
Query: 262 SNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMY 321
S+Q G + A + ++D+ +FV PAPQG TVRCR+ RDK+GMDRG++
Sbjct: 159 SSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLF 218
Query: 322 PSYFLHLDTEK--KVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRF 379
P+Y+++L+ E+ K+FLLA RKRK+SKTANYLISIDP +LSR GE+++GKLRSNL+G +F
Sbjct: 219 PTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKF 278
Query: 380 TVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIR 438
TV+D G P +G A RQELAA+ YETNVLGF+GPR+M+VIIPGM+ ++++P +
Sbjct: 279 TVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQ 338
Query: 439 PRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADD 498
P+N D LL RWQN+T+E+L+ELHNK PVWN D+ SY LNF+GRVTQASVKNFQIVH +D
Sbjct: 339 PQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKND 398
Query: 499 PDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE 542
PDYIV+QFGRVA+D FTLDY YPLCA+QAF I LSSFD KLACE
Sbjct: 399 PDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE 442
>gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens]
Length = 501
Score = 355 bits (910), Expect = 8e-98
Identities = 170/278 (61%), Positives = 218/278 (78%), Gaps = 3/278 (1%)
Query: 262 SNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMY 321
S+Q G + A + ++D+ +FV PAPQG TVRCR+ RDK+GMDRG++
Sbjct: 159 SSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLF 218
Query: 322 PSYFLHLDTEK--KVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRF 379
P+Y+++L+ E+ K+FLLA RKRK+SKTANYLISIDP +LSR GE+++GKLRSNL+G +F
Sbjct: 219 PTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKF 278
Query: 380 TVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIR 438
TV+D G P +G A RQELAA+ YETNVLGF+GPR+M+VIIPGM+ ++++P +
Sbjct: 279 TVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQ 338
Query: 439 PRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADD 498
P+N D LL RWQN+T+E+L+ELHNK PVWN D+ SY LNF+GRVTQASVKNFQIVH +D
Sbjct: 339 PQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKND 398
Query: 499 PDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFD 536
PDYIV+QFGRVA+D FTLDY YPLCA+QAF I LSSFD
Sbjct: 399 PDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFD 436
>gi|238859545 tubby like protein 2 [Homo sapiens]
Length = 520
Score = 302 bits (774), Expect = 4e-82
Identities = 173/400 (43%), Positives = 246/400 (61%), Gaps = 20/400 (5%)
Query: 147 LREKSSADLKERRAKAQGPRGDLGSPDPPP--KPLRVRNK--EAPAGEGTKMR-KTKKKG 201
L + S A+L+E + GS PPP + R+R K +A GT+ ++ +
Sbjct: 131 LPDNSDAELEEVSVEN-------GSVSPPPFKQSPRIRRKGWQAHQRPGTRAEGESDSQD 183
Query: 202 SGEADKDPSGSPASARKSPAAMF-LVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIK 260
G+A K P+ P L + D + ++ G EE + +K
Sbjct: 184 MGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKKREASESTGTNSSAAHNEELSKALK 243
Query: 261 KSNQKGKAKGKGKKKAKEE-RAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRG 319
+ G + +A R+P P +E D +VLRPA G ++C LTRDK G+D+G
Sbjct: 244 --GEGGTDSDHMRHEASLAIRSPCPGLEEDM-EAYVLRPALPGTMMQCYLTRDKHGVDKG 300
Query: 320 MYPSYFLHLDTEKKV--FLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGN 377
++P Y+L+L+T + FLLAGRKR+RSKT+NYLIS+DPT+LSR G+NF+GK+RSN+
Sbjct: 301 LFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRSNVFST 360
Query: 378 RFTVFDNGQNPQRGYST-NVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVP 436
+FT+FDNG NP R + T N A +RQEL AV YE NVLG+ GPR+MTVI+PG +++N+R+
Sbjct: 361 KFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRIN 420
Query: 437 IRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHA 496
++P N + LL R+Q + L+ LHNK P W+ ++G YTLNF GRVT+ASVKNFQIV
Sbjct: 421 VQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDP 480
Query: 497 DDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFD 536
+++VLQFGRV D FT+D+ +P LQAF+I LSSF+
Sbjct: 481 KHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICLSSFN 520
>gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens]
Length = 1543
Score = 72.8 bits (177), Expect = 8e-13
Identities = 37/77 (48%), Positives = 52/77 (67%), Gaps = 3/77 (3%)
Query: 463 NKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPL 522
NK P+WN+ + Y L+F GRVTQ S KNFQI + V+QFGR+ A+ LD++YP
Sbjct: 1469 NKQPLWNEATQVYQLDFGGRVTQESAKNFQI---ELEGRQVMQFGRIDGSAYILDFQYPF 1525
Query: 523 CALQAFAIALSSFDGKL 539
A+QAFA+AL++ +L
Sbjct: 1526 SAVQAFAVALANVTQRL 1542
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 72.4 bits (176), Expect = 1e-12
Identities = 87/333 (26%), Positives = 146/333 (43%), Gaps = 53/333 (15%)
Query: 16 SGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPS 75
S +EE+ SP + P++ +PA+ K EA +SP K + P P E S
Sbjct: 566 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA-KSP----EKAKSPVKEEAKSPAEAKS 620
Query: 76 PDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPD-AEDEEEEEEEDEED------- 127
P +A++P V + PE K +E A++P+ A+ E+EE + E
Sbjct: 621 PVKEEAKSPAEV-----KSPEKAKSPTKEE---AKSPEKAKSPEKEEAKSPEKAKSPVKA 672
Query: 128 EEEEAEEKKEKILLPPKKPLREKSSADLKERRA---KAQGP-RGDLGSPDPPPKPLRVRN 183
E + E+ K + K P EK+ + +KE KA+ P + + SP+ P++
Sbjct: 673 EAKSPEKAKSPVKAEAKSP--EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK--- 727
Query: 184 KEAPAGEGTKMRKTKKKGSGEADKDP------------SGSPASAR-KSPAAMFLVGEGS 230
+EA E K ++ S E K P + +PA +SPA F S
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 231 PDKKALKK--------KGTPKGARKEEEEEEEAATVIKKSNQKGKAKGK-GKKKAKEERA 281
P K+ +K K K KE ++EE + +K+ + + K K KKA+EE+A
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 282 PSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKK 314
P+ P + +E ++ AP+ + ++ K+
Sbjct: 848 PATP-KTEEKKDSKKEEAPKKEAPKPKVEEKKE 879
Score = 71.2 bits (173), Expect = 2e-12
Identities = 64/277 (23%), Positives = 113/277 (40%), Gaps = 13/277 (4%)
Query: 20 EESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPA 79
E++ SPE + + A+ K+ +P P K + P P + SP
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP--EKAKSPVKEEVKSPEKAKSPLKE 805
Query: 80 QARAPQTVYAR--FLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKE 137
A+AP+ + ++ P ++ P+E + AE+E+ E++++ +E+
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
Query: 138 KILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKT 197
K P K +K A K + +K + + + P P KEAPA K
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP----EKEAPAKVEVKEDAK 921
Query: 198 KKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALK--KKGTPKGARKEEEEEEEA 255
K+ + A K+P + A PA E +P+KK K K P+ K E + +E
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAEK---KEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 256 ATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPR 292
+ K K KA+ K + +++ PP + E +
Sbjct: 979 DKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 69.7 bits (169), Expect = 6e-12
Identities = 80/308 (25%), Positives = 133/308 (43%), Gaps = 44/308 (14%)
Query: 19 EEESLSPEAPRRP-KQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRT--GRPREEPS 75
+EE+ SPE + P K+ ++ + E +SP K + P +T + E +
Sbjct: 713 KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP----EKAKSPEKAKTLDVKSPEAKT 768
Query: 76 PDPAQARAPQTVYARFLRDP---EAKKRDPRETFLV--ARAPDAEDEEEEEEEDEEDEEE 130
P +AR+P + + P E K + ++ L A+AP+ E ++EE + EEE
Sbjct: 769 PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828
Query: 131 EAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGE 190
+ +E K K PPKK EK+ A K K + + PKP +V K+ PA E
Sbjct: 829 KPQEVKVKE--PPKKAEEEKAPATPKTEEKKDS--KKEEAPKKEAPKP-KVEEKKEPAVE 883
Query: 191 GTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEE 250
K +++K + E +D P +++PA + + + P +K K P A+ +E
Sbjct: 884 --KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
Query: 251 ----EEEEAATV--------IKKSNQKGKAKGKGK-------------KKAKEERAPSPP 285
E++EAA KK +K K + K K K K E++ S
Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001
Query: 286 VEVDEPRE 293
+ +P E
Sbjct: 1002 QKDSKPPE 1009
Score = 64.3 bits (155), Expect = 3e-10
Identities = 76/314 (24%), Positives = 134/314 (42%), Gaps = 45/314 (14%)
Query: 21 ESLSPEAPRRP----KQRPAPAQRLRKKRTEAPE-SPCPTGSKPRKPGAGRTGRPREEPS 75
E+ SPE + P + P A+ K+ ++PE + P + + P ++ P +E +
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS--PVKEEA 730
Query: 76 PDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE--EEEAE 133
P +A++P A+ PE K + L ++P+A+ +EE D+ E+
Sbjct: 731 KTPEKAKSPVKEEAK---SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 134 EKKEKILLPPK--KPLREKSSADLKE--RRAKAQGPRGDLGSPDP-----PPKPLRVRNK 184
KE++ P K PL+E + A KE ++ + + P + P PPK + +
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK--KAEEE 845
Query: 185 EAPAGEGTKMRKTKKKGSGEADKDP-----------SGSPASARKSPAAMFLVGEGSPDK 233
+APA KT++K + ++ P PA + + + E + DK
Sbjct: 846 KAPATP-----KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 234 KAL---KKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDE 290
K + +K+ K KE+ + +E V KK KAK K K+E AP + D
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE---KKDT 957
Query: 291 PREFVLRPAPQGRT 304
E +P + +T
Sbjct: 958 KEEKAKKPEEKPKT 971
Score = 60.5 bits (145), Expect = 4e-09
Identities = 66/296 (22%), Positives = 120/296 (40%), Gaps = 22/296 (7%)
Query: 5 DETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGA 64
+E E ++ EEE + ++ + E P + P K
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 65 GRTGRPREEPSPDPAQARAPQTVYARF---LRDPEAKKRDPRETFLVARAPDAEDEEEEE 121
P +E + PA+A++P+ A+ ++ PE K +E P+A+ E+EE
Sbjct: 518 S----PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE--AKSPPEAKSPEKEE 571
Query: 122 EE---DEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERR---AKAQGP-RGDLGSPDP 174
+ + + E+ KE+ P + EK+ + +KE A+A+ P + + SP
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
Query: 175 PPKPLRVRN---KEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSP 231
P + ++ +EA + E K + ++ S E K P + A + + + SP
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691
Query: 232 DKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAK---EERAPSP 284
+K K K K + +E A +K+ K + K +KAK +E A SP
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Score = 46.6 bits (109), Expect = 6e-05
Identities = 52/230 (22%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 1 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 60
+P ++E V + E + P P++ ++ APA +++ ++ + P P
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEP--PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP- 870
Query: 61 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPR-ETFLVARAPDAEDEEE 119
+P+ E +PA + ++ + E KK+ P E A+ ED +
Sbjct: 871 --------KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP 922
Query: 120 EEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSA----DLKERRAKAQGPRGDLGSPDPP 175
+E+ + +E + + KE P KP +K +A D KE +AK P+
Sbjct: 923 KEKTEVAKKEPDDAKAKE-----PSKPAEKKEAAPEKKDTKEEKAK---------KPEEK 968
Query: 176 PKPLRVRNKE---APAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAA 222
PK + KE + E +K + K + S D+ S P A + AA
Sbjct: 969 PK-TEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 43.1 bits (100), Expect = 6e-04
Identities = 54/199 (27%), Positives = 76/199 (38%), Gaps = 18/199 (9%)
Query: 104 ETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQ 163
E V + E EE+ +E EE E++E K+ E+ + +A+
Sbjct: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE------KEAKEEEGKEEEGGEEEEAE 495
Query: 164 GPRGDLGSPDPPPKPLRVRNKEA--PAGEGTKMRKTKKKGSGEADKDPS--GSPASARKS 219
G G+ + PP + KEA P E K K E K P+ SP A KS
Sbjct: 496 G--GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA-KS 552
Query: 220 PA---AMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKA 276
PA A SP+K+ K K K + +E A ++ KAK K++A
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612
Query: 277 KEERAPSPPV--EVDEPRE 293
K PV E P E
Sbjct: 613 KSPAEAKSPVKEEAKSPAE 631
>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
sapiens]
Length = 1616
Score = 63.5 bits (153), Expect = 5e-10
Identities = 67/283 (23%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 33 QRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQ-TVYARF 91
Q + A+R+ +P P PR+ + +P PSP + Q T+ + F
Sbjct: 112 QARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHF 171
Query: 92 LRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKIL--LPPKKPLRE 149
+ P KR P+E A++ DE +EE+ ++DE+ +E++ LP ++P R
Sbjct: 172 AKGP--AKRKPQEESERAKS----DESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERA 225
Query: 150 KSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDP 209
KS ++ + + L S P P + + KE P E + +AD+D
Sbjct: 226 KSGTRTEKEEERDEKEEKRLRSQTKEPTP-KQKLKEEPDREA--------RAGVQADEDE 276
Query: 210 SGSPASARKSPA-AMFLVGEGSPDKKALKKKGTPKGARKEEEEEEE--AATVIKKSNQKG 266
G +K + L + P++K +K K+E+E+EE T K+ +K
Sbjct: 277 DGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKK 336
Query: 267 KAKGKGKKKAKE-----------------ERAPSPPVEVDEPR 292
A+ K +K + PP VDEP+
Sbjct: 337 MARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQ 379
Score = 33.5 bits (75), Expect = 0.51
Identities = 37/161 (22%), Positives = 62/161 (38%), Gaps = 21/161 (13%)
Query: 143 PKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA------GEGTKMRK 196
P KPL + + RR+K+ G P+P P P R +G RK
Sbjct: 128 PPKPLSKPRTP----RRSKSDGE----AKPEPSPSPRITRKSTRQTTITSHFAKGPAKRK 179
Query: 197 TKKKG----SGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEE 252
+++ S E+ K+ R+ + V P ++ + K G R E+EEE
Sbjct: 180 PQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKS---GTRTEKEEE 236
Query: 253 EEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE 293
+ + +Q + K K K + +R V+ DE +
Sbjct: 237 RDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDED 277
Score = 29.3 bits (64), Expect = 9.6
Identities = 12/28 (42%), Positives = 17/28 (60%)
Query: 265 KGKAKGKGKKKAKEERAPSPPVEVDEPR 292
KGK KGKGK K++ P +E+ P+
Sbjct: 1111 KGKGKGKGKPKSQACEPSEPEIEIKLPK 1138
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 60.8 bits (146), Expect = 3e-09
Identities = 52/193 (26%), Positives = 86/193 (44%), Gaps = 19/193 (9%)
Query: 96 EAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADL 155
E ++R +++ + + + E E+ + +D + E KE+ PPK +E A L
Sbjct: 200 EHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMA-L 258
Query: 156 KERRAKAQGPRGDLGSPDPPP---KPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGS 212
KE + ++ P+G P PPP R ++P K +K+ KGS A P S
Sbjct: 259 KETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSA---PGTS 315
Query: 213 PASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKG 272
P R S ++ F DKK K K + +G + + E E A KK+ + ++ +
Sbjct: 316 P---RTSSSSSF------SDKKPAKDKSSTRGEKVKAESEPREA---KKALEVEESNSED 363
Query: 273 KKKAKEERAPSPP 285
+ K E A S P
Sbjct: 364 EASFKSESAQSSP 376
Score = 42.4 bits (98), Expect = 0.001
Identities = 56/246 (22%), Positives = 89/246 (36%), Gaps = 28/246 (11%)
Query: 21 ESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQ 80
ES SP+ P P P R KR +SP P+ K +K + + R P P
Sbjct: 264 ESTSPKGG--PPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGS---RSAPGTSPRT 318
Query: 81 ARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKIL 140
+ + + F AK + V + + ++ E +E + E+EA K E
Sbjct: 319 SSS-----SSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQ 373
Query: 141 LPPKKPLR---EKSSADLKERRAKAQGP--------RGDLGSPDPPPKPLRVRNKEAPAG 189
P S +D + + +QGP + + D K P G
Sbjct: 374 SSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNP-G 432
Query: 190 EGTKMRKTKKKGSGEADKD-PSGSPASARKSPAAMFLV-GEGSPDK----KALKKKGTPK 243
+++ + + AD PS P +K P V G SP+ + + KKGT
Sbjct: 433 RDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYD 492
Query: 244 GARKEE 249
A +E
Sbjct: 493 KAYTDE 498
Score = 30.4 bits (67), Expect = 4.3
Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 23/123 (18%)
Query: 171 SPDPPPKPLRVRNKEAPAGEGTKMRKTKKK-GSGEADKDPSGSPASARKSPAAMFLVGEG 229
SPD P P P + +KTK GS +A+K+ S + + +
Sbjct: 155 SPDYPMLPT------IPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVT---------- 198
Query: 230 SPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVD 289
++ +K K + KE E E+ K S + G+G+ KEE+AP P
Sbjct: 199 KEHRERPRKDSESKSSSKELEREQA-----KSSKDTSRKLGEGRLP-KEEKAPPPKAAFK 252
Query: 290 EPR 292
EP+
Sbjct: 253 EPK 255
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 60.5 bits (145), Expect = 4e-09
Identities = 75/313 (23%), Positives = 122/313 (38%), Gaps = 44/313 (14%)
Query: 14 SDSGHEEESLSPEAP--RRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPR 71
SDS EEE P + +P PA++ + +++ +S + AG T
Sbjct: 329 SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSS 388
Query: 72 EEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEE 131
+P+ ++P A + P + L+ R D+ EEE EE
Sbjct: 389 NKPA---VTTKSPAVKPAAAPKQPVGGGQK-----LLTRKADSSSSEEESSSSEE----- 435
Query: 132 AEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKP----------LRV 181
EK +K++ K K++ L ++A QG R D ++
Sbjct: 436 --EKTKKMVATTKPKATAKAALSLPAKQAP-QGSRDSSSDSDSSSSEEEEEKTSKSAVKK 492
Query: 182 RNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGT 241
+ ++ G + KKG E+ S +S + L G+GSP +A K GT
Sbjct: 493 KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK---LKGKGSPRPQAPKANGT 549
Query: 242 P-------KGAR--KEEEEEE-EAATVIKKSNQKGKAKGKGKKKAKEERAP-SPPVEVDE 290
K A+ +EEEEE+ +AA V+ KS K K + AKE P + +++
Sbjct: 550 SALTAQNGKAAKNSEEEEEEKKKAAVVVSKSG--SLKKRKQNEAAKEAETPQAKKIKLQT 607
Query: 291 PREFVLRPAPQGR 303
P F R + R
Sbjct: 608 PNTFPKRKKGEKR 620
Score = 52.8 bits (125), Expect = 8e-07
Identities = 69/301 (22%), Positives = 108/301 (35%), Gaps = 40/301 (13%)
Query: 13 ASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPRE 72
AS+S EES + K++P Q+ K + +A ++P K + + +
Sbjct: 123 ASESSSSEESSDDDDEEDQKKQPV--QKGVKPQAKAAKAP---PKKAKSSDSDSDSSSED 177
Query: 73 EPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEA 132
EP + P TV A+ P+ + P+ +A A D+ EE
Sbjct: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPK----IANGKAASSSSSSSSSSSSDDSEEE 233
Query: 133 E---------EKKEKILLPPKK----PLR-----EKSSADLKERRAKAQ----GPRGDLG 170
+ KK+ + P K P R E SS+D +E + K GP +
Sbjct: 234 KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP 293
Query: 171 SPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGS 230
P PP P + + P + K + S E D S S + K P +V + +
Sbjct: 294 PPSAPP-PKKSLGTQPPK---KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
Query: 231 ----PDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKA-KEERAPSPP 285
P KKA + + E++E + N K K A K AP P
Sbjct: 350 TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409
Query: 286 V 286
V
Sbjct: 410 V 410
Score = 52.4 bits (124), Expect = 1e-06
Identities = 62/273 (22%), Positives = 100/273 (36%), Gaps = 27/273 (9%)
Query: 13 ASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKP-RKPGAGRTGRPR 71
AS S S S + K P + + KK+ A ++P + P RK +
Sbjct: 215 ASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA-KAPVKAATTPTRKSSSSEDSSSD 273
Query: 72 EEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEE 131
EE P + P P+++ L + P E+++ E ED +E
Sbjct: 274 EEEEQKKPMKNKP----GPYSSVPPPSAPPPKKS-LGTQPPKKAVEKQQPVESSEDSSDE 328
Query: 132 AEEKKEKILLPPKKPLREKSSA--DLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAG 189
++ E+ PP K + K++ ++ A++ D S + P + PAG
Sbjct: 329 SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK------PAG 382
Query: 190 EGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEE 249
K K P+ PA+A K P VG G +K L +K + +E
Sbjct: 383 ----TTKNSSNKPAVTTKSPAVKPAAAPKQP-----VGGG---QKLLTRKADSSSSEEES 430
Query: 250 EEEEEAATVIKKSNQKGKAKGKGKKKAKEERAP 282
EE T + K KA K ++AP
Sbjct: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAKQAP 463
Score = 45.1 bits (105), Expect = 2e-04
Identities = 48/198 (24%), Positives = 78/198 (39%), Gaps = 30/198 (15%)
Query: 95 PEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPL------- 147
P AKK + A + D+ED EEEEE + ++A +++ LPP K
Sbjct: 73 PVAKKAKKK-----ASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESS 127
Query: 148 -REKSSADLKERRAKAQ----GPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGS 202
E+SS D E K Q G + + PPK + + ++ + + K +K
Sbjct: 128 SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQK--- 184
Query: 203 GEADKDPSGSPASARKSPAAMFLVGEGSP----DKKALKKKGTPKGARKEEEEEEEAATV 258
P +P + + A +P K A + + ++ EEE+AA
Sbjct: 185 ------PKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT 238
Query: 259 IKKSNQKGKAKGKGKKKA 276
KK+ K + K KA
Sbjct: 239 PKKTVPKKQVVAKAPVKA 256
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 7/108 (6%)
Query: 191 GTKMRKTKKKGSG-------EADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPK 243
G +K KKK S E +++ G PA PA + G KA + + +
Sbjct: 72 GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEE 131
Query: 244 GARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEP 291
+ ++EE+++ V K + KA KKAK + S DEP
Sbjct: 132 SSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP 179
Score = 30.8 bits (68), Expect = 3.3
Identities = 23/82 (28%), Positives = 32/82 (39%), Gaps = 4/82 (4%)
Query: 225 LVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKK----SNQKGKAKGKGKKKAKEER 280
L G KKA KK + EEEEE KK + + G GK KA E
Sbjct: 68 LQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESS 127
Query: 281 APSPPVEVDEPREFVLRPAPQG 302
+ + D+ + +P +G
Sbjct: 128 SSEESSDDDDEEDQKKQPVQKG 149
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 60.1 bits (144), Expect = 5e-09
Identities = 69/291 (23%), Positives = 122/291 (41%), Gaps = 25/291 (8%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTG 68
RE D G E++SL+ + P++ ++ R +KR E + K ++ R
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARV----KEKEREHERRK 124
Query: 69 RPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE 128
R REE D A+ + R+ ++RD E R + + E+++E+ E+ E
Sbjct: 125 RHREEQ--DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 182
Query: 129 EEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA 188
E E++ K ++ RE S+ R + + S PP P +
Sbjct: 183 RERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP----RERFEL 234
Query: 189 GEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKKKGTPKGA 245
G+G K K +K + D S RK+ +A G GS +++ +++ +G+
Sbjct: 235 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 294
Query: 246 RKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 295 TSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340
Score = 33.5 bits (75), Expect = 0.51
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 206 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 265
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 266 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 321
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 322 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 381
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 382 YVPDSPALSPIELKQELPKYLPALQGCR 409
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 60.1 bits (144), Expect = 5e-09
Identities = 69/291 (23%), Positives = 122/291 (41%), Gaps = 25/291 (8%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTG 68
RE D G E++SL+ + P++ ++ R +KR E + K ++ R
Sbjct: 35 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARV----KEKEREHERRK 90
Query: 69 RPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE 128
R REE D A+ + R+ ++RD E R + + E+++E+ E+ E
Sbjct: 91 RHREEQ--DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 148
Query: 129 EEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA 188
E E++ K ++ RE S+ R + + S PP P +
Sbjct: 149 RERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP----RERFEL 200
Query: 189 GEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKKKGTPKGA 245
G+G K K +K + D S RK+ +A G GS +++ +++ +G+
Sbjct: 201 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 260
Query: 246 RKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 261 TSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 306
Score = 33.5 bits (75), Expect = 0.51
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 172 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 231
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 287
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 288 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 347
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 348 YVPDSPALSPIELKQELPKYLPALQGCR 375
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/286 (24%), Positives = 116/286 (40%), Gaps = 25/286 (8%)
Query: 13 ASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPRE 72
+S S + P R+P ++P P R RK + E P S + S + + R+
Sbjct: 261 SSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRD 320
Query: 73 EPSPDPAQA--RAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDE-----EEEEEEDE 125
E +A R Q R LR+ E ++++ R RA E E +E E
Sbjct: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRR----ERADRGEAERGSGGSSGDELRE 376
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSP--DPPPKPLRVRN 183
+DE + +K + PP E + +E + A+ P+ P P K RVR
Sbjct: 377 DDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRP 436
Query: 184 KEAPAGEGTKMRKTKKKGSG-------EADKDPSGSPASARKSPAAMFLVGEGSPDKK-- 234
+E + K+ +T+K+ G E K+PS + F + SPD K
Sbjct: 437 EEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRC 496
Query: 235 --ALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKE 278
AL++ GT + + ++ + +KK ++ KA +KA E
Sbjct: 497 LNALEELGTLQVTSQILQKNTDVVATLKKI-RRYKANKDVMEKAAE 541
Score = 44.3 bits (103), Expect = 3e-04
Identities = 62/278 (22%), Positives = 99/278 (35%), Gaps = 43/278 (15%)
Query: 14 SDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKP-RKP---GAGRTGR 69
SDS + + PE + + + ++ P G KP KP GR +
Sbjct: 234 SDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPK 293
Query: 70 PREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEE 129
P PS + + + + R E K+RD R +A E+EEE E
Sbjct: 294 PERPPSSSSSDSDSDEVD-----RISEWKRRDEARR----RELEARRRREQEEELRRLRE 344
Query: 130 EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAG 189
+E EEK+ + +ER + + RG GS +R + P
Sbjct: 345 QEKEEKERR-----------------RERADRGEAERGSGGSSGD-----ELREDDEPV- 381
Query: 190 EGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEE 249
K R K +G G S A + + S + A K K R EE
Sbjct: 382 ---KKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
Query: 250 EEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
+++ A +K + +++G + K E+ P VE
Sbjct: 439 KQQ---AKPVKVERTRKRSEGFSMDR-KVEKKKEPSVE 472
Score = 33.1 bits (74), Expect = 0.66
Identities = 48/225 (21%), Positives = 76/225 (33%), Gaps = 42/225 (18%)
Query: 111 APDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLG 170
A A D E + + ++ + ++K L K+S+DL +
Sbjct: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
Query: 171 SPDP---------PPKPLRVRN-KEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSP 220
S + P K VR + P G + KKK +D D A+ P
Sbjct: 193 SSESEKTSDQDFTPEKKAAVRAPRRGPLGG-----RKKKKAPSASDSDSKADSDGAKPEP 247
Query: 221 AAMFLVGEGSPDKKA-----LKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKK 275
AM S + + K P+G +K +K K +G +K
Sbjct: 248 VAMARSASSSSSSSSSSDSDVSVKKPPRG---------------RKPAEKPLPKPRG-RK 291
Query: 276 AKEERAPSPPV------EVDEPREFVLRPAPQGRTVRCRLTRDKK 314
K ER PS EVD E+ R + R + R R+++
Sbjct: 292 PKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Score = 32.7 bits (73), Expect = 0.87
Identities = 45/223 (20%), Positives = 84/223 (37%), Gaps = 29/223 (13%)
Query: 70 PREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVAR----APDAEDEEEEEEEDE 125
P EE + + + + + +T F + +A R PR L R AP A D + + + D
Sbjct: 184 PSEEENSE-SSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDG 242
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKE 185
K E + + SS+ + + PRG + P PKP
Sbjct: 243 A--------KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP------- 287
Query: 186 APAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGA 245
G K + S ++D D + ++ A + +A +++ +
Sbjct: 288 --RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR------RRELEARRRREQEEEL 339
Query: 246 RK-EEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
R+ E+E+EE +++++ +G G E R PV+
Sbjct: 340 RRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVK 382
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/286 (24%), Positives = 116/286 (40%), Gaps = 25/286 (8%)
Query: 13 ASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPRE 72
+S S + P R+P ++P P R RK + E P S + S + + R+
Sbjct: 261 SSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRD 320
Query: 73 EPSPDPAQA--RAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDE-----EEEEEEDE 125
E +A R Q R LR+ E ++++ R RA E E +E E
Sbjct: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRR----ERADRGEAERGSGGSSGDELRE 376
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSP--DPPPKPLRVRN 183
+DE + +K + PP E + +E + A+ P+ P P K RVR
Sbjct: 377 DDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRP 436
Query: 184 KEAPAGEGTKMRKTKKKGSG-------EADKDPSGSPASARKSPAAMFLVGEGSPDKK-- 234
+E + K+ +T+K+ G E K+PS + F + SPD K
Sbjct: 437 EEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRC 496
Query: 235 --ALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKE 278
AL++ GT + + ++ + +KK ++ KA +KA E
Sbjct: 497 LNALEELGTLQVTSQILQKNTDVVATLKKI-RRYKANKDVMEKAAE 541
Score = 44.3 bits (103), Expect = 3e-04
Identities = 62/278 (22%), Positives = 99/278 (35%), Gaps = 43/278 (15%)
Query: 14 SDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKP-RKP---GAGRTGR 69
SDS + + PE + + + ++ P G KP KP GR +
Sbjct: 234 SDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPK 293
Query: 70 PREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEE 129
P PS + + + + R E K+RD R +A E+EEE E
Sbjct: 294 PERPPSSSSSDSDSDEVD-----RISEWKRRDEARR----RELEARRRREQEEELRRLRE 344
Query: 130 EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAG 189
+E EEK+ + +ER + + RG GS +R + P
Sbjct: 345 QEKEEKERR-----------------RERADRGEAERGSGGSSGD-----ELREDDEPV- 381
Query: 190 EGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEE 249
K R K +G G S A + + S + A K K R EE
Sbjct: 382 ---KKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
Query: 250 EEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
+++ A +K + +++G + K E+ P VE
Sbjct: 439 KQQ---AKPVKVERTRKRSEGFSMDR-KVEKKKEPSVE 472
Score = 33.1 bits (74), Expect = 0.66
Identities = 48/225 (21%), Positives = 76/225 (33%), Gaps = 42/225 (18%)
Query: 111 APDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLG 170
A A D E + + ++ + ++K L K+S+DL +
Sbjct: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
Query: 171 SPDP---------PPKPLRVRN-KEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSP 220
S + P K VR + P G + KKK +D D A+ P
Sbjct: 193 SSESEKTSDQDFTPEKKAAVRAPRRGPLGG-----RKKKKAPSASDSDSKADSDGAKPEP 247
Query: 221 AAMFLVGEGSPDKKA-----LKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKK 275
AM S + + K P+G +K +K K +G +K
Sbjct: 248 VAMARSASSSSSSSSSSDSDVSVKKPPRG---------------RKPAEKPLPKPRG-RK 291
Query: 276 AKEERAPSPPV------EVDEPREFVLRPAPQGRTVRCRLTRDKK 314
K ER PS EVD E+ R + R + R R+++
Sbjct: 292 PKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Score = 32.7 bits (73), Expect = 0.87
Identities = 45/223 (20%), Positives = 84/223 (37%), Gaps = 29/223 (13%)
Query: 70 PREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVAR----APDAEDEEEEEEEDE 125
P EE + + + + + +T F + +A R PR L R AP A D + + + D
Sbjct: 184 PSEEENSE-SSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDG 242
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKE 185
K E + + SS+ + + PRG + P PKP
Sbjct: 243 A--------KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP------- 287
Query: 186 APAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGA 245
G K + S ++D D + ++ A + +A +++ +
Sbjct: 288 --RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR------RRELEARRRREQEEEL 339
Query: 246 RK-EEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
R+ E+E+EE +++++ +G G E R PV+
Sbjct: 340 RRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVK 382
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 59.3 bits (142), Expect = 9e-09
Identities = 67/267 (25%), Positives = 113/267 (42%), Gaps = 39/267 (14%)
Query: 19 EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDP 78
E + +PE + P ++K + P T +KP + +EEPSP
Sbjct: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSV--TEKEVPSKEEPSPVK 617
Query: 79 AQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEK 138
A+ Q + P+A K + + D ++E+E+ +++ +E++ KKE+
Sbjct: 618 AEVAEKQATDVK----PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEE 673
Query: 139 ILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTK 198
P K+ ++++ ++K+ K P+ ++ + PPK ++ K+ E K K
Sbjct: 674 --KPKKEEVKKEVKKEIKKEEKKE--PKKEV-KKETPPKEVKKEVKKEEKKEVKKEEKEP 728
Query: 199 KKGSGEADKD--PSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAA 256
KK + KD S +P S K PAA+ PK +KEE
Sbjct: 729 KKEIKKLPKDAKKSSTPLSEAKKPAAL-----------------KPKVPKKEE------- 764
Query: 257 TVIKKSNQKGKAKGKGKKKA--KEERA 281
+V K S GK K KGK K KE +A
Sbjct: 765 SVKKDSVAAGKPKEKGKIKVIKKEGKA 791
Score = 53.5 bits (127), Expect = 5e-07
Identities = 65/295 (22%), Positives = 123/295 (41%), Gaps = 33/295 (11%)
Query: 60 RKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEE 119
++P A + + P+P Q + Q +R P AK L +++ E +EE
Sbjct: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKP-------LPSKSVRKESKEE 564
Query: 120 EEEEDEEDEEEEAE--EKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPK 177
E + + E+ E KEK+++ KP++ ++ + E+ ++ +P P
Sbjct: 565 TPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSK--------EEPSPV 616
Query: 178 PLRVRNKEAP------AGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSP 231
V K+A A E T ++TK K + ++ A+K + E P
Sbjct: 617 KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTP-IKKEEKP 675
Query: 232 DKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEP 291
K+ +KK+ K +KEE++E KK +K + KK+ K+E E EP
Sbjct: 676 KKEEVKKE-VKKEIKKEEKKEP------KKEVKKETPPKEVKKEVKKEEKKEVKKEEKEP 728
Query: 292 REFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSK 346
++ + + + L+ KK + P ++ KK + AG+ +++ K
Sbjct: 729 KKEIKKLPKDAKKSSTPLSEAKK--PAALKPKVPKKEESVKKDSVAAGKPKEKGK 781
Score = 51.2 bits (121), Expect = 2e-06
Identities = 68/260 (26%), Positives = 99/260 (38%), Gaps = 32/260 (12%)
Query: 46 TEAPESPCP-TGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRE 104
TE E P +G P PG + GR +E P AP + P E
Sbjct: 2116 TEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPS----------QTDSDVPPE 2165
Query: 105 TFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSA----DLKERRA 160
T P + + EDE + + K + PP P++++S + D+
Sbjct: 2166 T---EECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDP 2222
Query: 161 KAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSP 220
+A +LG K L+ + K G TK KK G++ K + SP A
Sbjct: 2223 EALAIEQNLGK--ALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKS-KPLAASPKPAGLKE 2279
Query: 221 AAMFLVGEGSPDK-----KALKKKGTP--KGARKEEEEEE--EAATVIKKSNQKGKAKGK 271
++ + SP K KA K TP K AR EE+++E AA + K G
Sbjct: 2280 SSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGP 2339
Query: 272 GKKKAKEERA--PSPPVEVD 289
G K + A P PV +D
Sbjct: 2340 GTTKTTKSSAVPPGLPVYLD 2359
Score = 50.4 bits (119), Expect = 4e-06
Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 25/222 (11%)
Query: 43 KKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDP 102
K TE E P G + A + P+ D A+A Y R R+ A D
Sbjct: 945 KAETEEAEEPEEDGEEHVCVSASK-----HSPTEDEESAKAEADAYIREKRESVASGDDR 999
Query: 103 RETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKA 162
E + E E+ EEE DEED+ E+A E++ + P+K E + ++ A+A
Sbjct: 1000 AEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYE----PEKMEAEDYVMAVVDKAAEA 1055
Query: 163 QG----------PRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGS 212
G P LG+ P +P + E G G++ T D+ P
Sbjct: 1056 GGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPG-GSESEATASDEENREDQ-PEEF 1113
Query: 213 PASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEE 254
A++ + + + + E +P + + TP+ +E EE
Sbjct: 1114 TATSGYTQSTIEISSEPTP----MDEMSTPRDVMSDETNNEE 1151
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 27/230 (11%)
Query: 91 FLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREK 150
FL+ P A ++D L + P ++ + ++ + E L P KPL K
Sbjct: 510 FLKQPLATQKD-----LTGQVPTPVVKQTKLKQRADSRES---------LKPAAKPLPSK 555
Query: 151 SSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPS 210
S + +K + P ++ + KP +V +KE + K KT+ K S + PS
Sbjct: 556 SV----RKESKEETP--EVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPS 609
Query: 211 GSPASARKSPAAMFLVGEGSPD---KKALKKKGTPKGARKEEEEEEEAATVIKKSNQ--- 264
S K+ A + P +K +KK+ K K+EE+E+ V KK ++
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPI 669
Query: 265 KGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKK 314
K + K K ++ KE + E EP++ V + P + V+ + +++K
Sbjct: 670 KKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP-KEVKKEVKKEEK 718
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/294 (22%), Positives = 117/294 (39%), Gaps = 22/294 (7%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEA---PESPCPTGSKPRKPGAG 65
RE D G E++SL+ + P++ ++ R +KR E G R
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKERE 128
Query: 66 RTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDE 125
R R D A+ + R+ ++RD E R + + E+++E+ E
Sbjct: 129 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 188
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKE 185
+ E E E++ K ++ RE S+ R + + S PP P +
Sbjct: 189 QKERERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP----RER 240
Query: 186 APAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKKKGTP 242
G+G K K +K + D S RK+ +A G GS +++ +++
Sbjct: 241 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 300
Query: 243 KGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
+G+ EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 301 EGSTSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349
Score = 32.7 bits (73), Expect = 0.87
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 215 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 274
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 330
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 331 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 390
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 391 YVPDSPALLPIELKQELPKYLPALQGCR 418
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/293 (22%), Positives = 116/293 (39%), Gaps = 42/293 (14%)
Query: 26 EAPRRPKQRPAPAQRLRKKRTEAPES-PCPTGSKP----RKPGAGRTGRPR-----EEPS 75
E+ +QR PAQR + E + T KP + PG R + EE
Sbjct: 141 ESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESE 200
Query: 76 PDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEK 135
+P Q A + + + + +++ E L + + EEE EEE++E++EE+ + K
Sbjct: 201 AEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKE--QREEEVEEEEKEEDEEKGDWK 258
Query: 136 KEKILLPPKKPLREKSS-------------ADLKERRAKAQGPRGDLGSPDPPPKPLRVR 182
+K RE+ S +D +E + +A D G PP V+
Sbjct: 259 PRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPP----VQ 314
Query: 183 NKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKK--- 239
K + + T+++ K+ D++ SG K M +G S ++ L+++
Sbjct: 315 RK---SEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSD 371
Query: 240 ----GTPKGARK---EEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPP 285
G P+G RK ++ + T S+ G + KG K R P
Sbjct: 372 SEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHP 424
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/241 (20%), Positives = 84/241 (34%), Gaps = 4/241 (1%)
Query: 49 PESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLV 108
P+ T S R+ +GR EP A R + + D A + D +
Sbjct: 19 PDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKK 78
Query: 109 ARAPDA--EDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPR 166
+ P D E + + E +E PP K + KE +
Sbjct: 79 GKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKA 138
Query: 167 GDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV 226
+ S + + L + E + E K K K + K G + +RK
Sbjct: 139 VEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEE 198
Query: 227 GEGSPDKKALKKKGTPKGARKEEEEEEEAATVI--KKSNQKGKAKGKGKKKAKEERAPSP 284
E P ++ KK KG + +E E+E+ I +K Q+ + + +K+ EE+
Sbjct: 199 SEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWK 258
Query: 285 P 285
P
Sbjct: 259 P 259
Score = 32.0 bits (71), Expect = 1.5
Identities = 64/309 (20%), Positives = 110/309 (35%), Gaps = 60/309 (19%)
Query: 4 RDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPG 63
+ + R + SDS E++ + + R P QR + RT+ +GS +
Sbjct: 279 KSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEED 338
Query: 64 AGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEE 123
+G+ G P + S R+ + E + E E
Sbjct: 339 SGK-GEPTAKGS---------------------------RKMARLGSTSGEESDLEREVS 370
Query: 124 DEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRN 183
D E E+K + + R +SS+ + +A+G + G R
Sbjct: 371 DSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGR----------RG 420
Query: 184 KEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPK 243
++ PA K R + G+ K GS S ++ + + + +AL KGTP
Sbjct: 421 EDHPAVMRLK-RYIRACGAHRNYKKLLGSCCSHKERLSIL------RAELEALGMKGTPS 473
Query: 244 -GARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAP----SPPVEV-------DEP 291
G + +E+ E A + + G G+ + + P +PP E+ DE
Sbjct: 474 LGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEE 533
Query: 292 REFVLRPAP 300
R RPAP
Sbjct: 534 RP---RPAP 539
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 33/288 (11%)
Query: 19 EEESLSPEAPRRPKQRPAPAQ-RLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPD 77
+ ++ P P RP PA L +K E ++ S+ +K + E+ +
Sbjct: 286 QSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAI 345
Query: 78 PAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEE------DEEDEEEE 131
+ + P +A + + A+A +DE++E+ + + E + +
Sbjct: 346 DVEKKEPG----------KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGK 395
Query: 132 AEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEG 191
+EKKEK + P K P +E S K+ +AK + + ++G+ V K+A G+
Sbjct: 396 KQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA---------VSIKKAVPGK- 445
Query: 192 TKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEE 251
K KT K E K+ SG +S K + +G +K K +K+E+
Sbjct: 446 -KEEKTTKTVEQEIRKEKSGKTSSILKDKEPI----KGKEEKVPASLKEKEPETKKDEKM 500
Query: 252 EEEAATVIKKSNQ-KGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRP 298
+ V K Q +GK + K + + K+E P+ +V ++ +++P
Sbjct: 501 SKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKP 548
Score = 54.3 bits (129), Expect = 3e-07
Identities = 72/321 (22%), Positives = 125/321 (38%), Gaps = 46/321 (14%)
Query: 8 LREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRT 67
L ++ +S+ +++ + P + + K +TE E P RK T
Sbjct: 110 LSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKP------ERKIQTKVT 163
Query: 68 GRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEED 127
+ +E+ + P+ ++ KK P L A+ E+ EE+ +++
Sbjct: 164 HKEKEKGKEKVREKEKPEKKATH--KEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE 221
Query: 128 ----EEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPR----------------G 167
++E+ ++ K+ K P + K D KE+ A ++ + G
Sbjct: 222 VKGGKQEKVKQTAAKVKEVQKTPSKPKEKED-KEKAAVSKHEQKDQYAFCRYMIDIFVHG 280
Query: 168 DL---GSPD-PPPKPLRVRNKEAPAG------EGTKMRKTKKKGSGEADKDPSGSPASAR 217
DL SP PPP P ++ PA EG K + KK S K+ +
Sbjct: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSE 340
Query: 218 KSPAAMFLVGEGSPDKKALKKKGTPK-----GARKEEEEEEEAATVIKKSNQKGKAKGKG 272
K A V + P K + K+GT K A+K+E++E+ T ++ K K +
Sbjct: 341 KETA--IDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQE 398
Query: 273 KKKAKEERAPSPPVEVDEPRE 293
KK+ E A SP E P +
Sbjct: 399 KKEKHVEPAKSPKKEHSVPSD 419
Score = 32.7 bits (73), Expect = 0.87
Identities = 46/221 (20%), Positives = 80/221 (36%), Gaps = 26/221 (11%)
Query: 6 ETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAG 65
ET ++ S +G E + P+ + +++P P + K + + +
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV 552
Query: 66 RTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDE 125
G+P E+ +T + + E ++R+P P + E E +
Sbjct: 553 SHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGK 612
Query: 126 EDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRN-- 183
+ E +E KEK K LRE+ + KE L + KP RV
Sbjct: 613 KKTEISEKESKEK---ADMKHLREEKVSTRKESL--------QLHNVTKAEKPARVSKDV 661
Query: 184 KEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMF 224
++ PA +KK G D P + +KSP + F
Sbjct: 662 EDVPA--------SKKAKEGTEDVSP-----TKQKSPISFF 689
Score = 30.4 bits (67), Expect = 4.3
Identities = 47/256 (18%), Positives = 88/256 (34%), Gaps = 29/256 (11%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKK-RTEAPESPCPTGSKPRKPGAGRT 67
+E+ SG L + P + K+ PA K+ T+ E G + +
Sbjct: 456 QEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQ 515
Query: 68 GRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEED 127
G+ E+P +P+ KK A+ +E + +++ +
Sbjct: 516 GKKEEKP-------------------EPQIKKE--------AKPAISEKVQIHKQDIVKP 548
Query: 128 EEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAP 187
E+ + K E+ +L K + + +A K + R PKP E
Sbjct: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT 608
Query: 188 AGEGTKMRKTKKKGSGEAD-KDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGAR 246
K ++K+ +AD K S RK + V + + K ++
Sbjct: 609 ESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668
Query: 247 KEEEEEEEAATVIKKS 262
K +E E+ + +KS
Sbjct: 669 KAKEGTEDVSPTKQKS 684
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/291 (23%), Positives = 123/291 (42%), Gaps = 26/291 (8%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTG 68
RE D G E++SL+ + P++ ++ R +KR E + ++ ++ R
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKH-----ARVKEREHERRK 123
Query: 69 RPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE 128
R REE D A+ + R+ ++RD E R + + E+++E+ E+ E
Sbjct: 124 RHREEQ--DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 181
Query: 129 EEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA 188
E E++ K ++ RE S+ R + + S PP P +
Sbjct: 182 RERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP----RERFEL 233
Query: 189 GEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKKKGTPKGA 245
G+G K K +K + D S RK+ +A G GS +++ +++ +G+
Sbjct: 234 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 293
Query: 246 RKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 294 TSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339
Score = 32.7 bits (73), Expect = 0.87
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 205 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 264
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 265 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 320
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 321 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 380
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 381 YVPDSPALLPIELKQELPKYLPALQGCR 408
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/298 (23%), Positives = 123/298 (41%), Gaps = 28/298 (9%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTE-------APESPCPTGSKPRK 61
RE D G E++SL+ + P++ ++ R +KR E + E K ++
Sbjct: 35 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE 94
Query: 62 PGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEE 121
R R REE D A+ + R+ ++RD E R + + E+++
Sbjct: 95 REHERRKRHREEQ--DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 152
Query: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
E+ E+ E E E++ K ++ RE S+ R + + S PP P
Sbjct: 153 EQREQKERERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP--- 205
Query: 182 RNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKK 238
+ G+G K K +K + D S RK+ +A G GS +++ ++
Sbjct: 206 -RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 264
Query: 239 KGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
+ +G+ EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 265 EEEEEGSTSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 317
Score = 33.5 bits (75), Expect = 0.51
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 183 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 242
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 243 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 298
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 299 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 358
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 359 YVPDSPALSPIELKQELPKYLPALQGCR 386
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/298 (23%), Positives = 123/298 (41%), Gaps = 28/298 (9%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTE-------APESPCPTGSKPRK 61
RE D G E++SL+ + P++ ++ R +KR E + E K ++
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE 128
Query: 62 PGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEE 121
R R REE D A+ + R+ ++RD E R + + E+++
Sbjct: 129 REHERRKRHREEQ--DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 186
Query: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
E+ E+ E E E++ K ++ RE S+ R + + S PP P
Sbjct: 187 EQREQKERERRAEERRK----EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP--- 239
Query: 182 RNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLV---GEGSPDKKALKK 238
+ G+G K K +K + D S RK+ +A G GS +++ ++
Sbjct: 240 -RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 298
Query: 239 KGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE---VDEPRE 293
+ +G+ EE EEEE ++ ++ + G ++A E+ A E DE RE
Sbjct: 299 EEEEEGSTSEESEEEE-----EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351
Score = 33.5 bits (75), Expect = 0.51
Identities = 37/208 (17%), Positives = 77/208 (37%), Gaps = 25/208 (12%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPK------QRPAPAQRLRKKRT-----EAPESPCPT 55
T+RE ++ S SP P R + ++P +++ ++ + +S T
Sbjct: 217 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 276
Query: 56 GSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAE 115
S +G EE + + + + + E ++ + E + + +A
Sbjct: 277 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES----EEEEEEEEEEEEETGSNSEEAS 332
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQG-------PRGD 168
++ EE +EE E+E E + +L+ P+ S + +G GD
Sbjct: 333 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 392
Query: 169 LGSPDPPPKPLRVRN---KEAPAGEGTK 193
P P+ ++ K PA +G +
Sbjct: 393 YVPDSPALSPIELKQELPKYLPALQGCR 420
>gi|4557719 DNA ligase I [Homo sapiens]
Length = 919
Score = 57.8 bits (138), Expect = 3e-08
Identities = 69/273 (25%), Positives = 102/273 (37%), Gaps = 61/273 (22%)
Query: 11 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRP 70
V S+ E+E+LSP + + P C S PR +
Sbjct: 63 VLGSEGEEEDEALSPA------------------KGQKPALDCSQVSPPRPATSPENNAS 104
Query: 71 REEPSP-DPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEE 129
+ SP D + + P+ AR K+ P+ T +EDE+ E + +E+EE
Sbjct: 105 LSDTSPMDSSPSGIPKRRTAR--------KQLPKRTIQEVLEEQSEDEDREAKRKKEEEE 156
Query: 130 EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAG 189
EE PK+ L E A KE G GD P PPKPL+ E P
Sbjct: 157 EET----------PKESLTEAEVATEKE------GEDGD--QPTTPPKPLKTSKAETPT- 197
Query: 190 EGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEE 249
E + K + +++ + P A K+ ++ F +P K A+KK E
Sbjct: 198 ESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFF-----TPRKPAVKK----------E 242
Query: 250 EEEEEAATVIKKSNQKGKAKGKGKKKAKEERAP 282
+EEE K+ +G G AK P
Sbjct: 243 VKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/198 (25%), Positives = 74/198 (37%), Gaps = 32/198 (16%)
Query: 120 EEEEDEEDEEEEAEEKKEKILLPPKKPLRE------KSSADLKERRAKAQGPRGDLG--- 170
++E + E+EA + PPK L+E +S + +K KA G G
Sbjct: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEE 71
Query: 171 ----SPDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPA--SARKS---P 220
SP KP ++ +P T + D PSG P +ARK
Sbjct: 72 DEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKR 131
Query: 221 AAMFLVGEGSPDKKALKKKGTPKGARKEEEEEE-------EAATVIKKSNQKGKAKGKGK 273
++ E S D+ K+ +KEEEEEE EA +K + G
Sbjct: 132 TIQEVLEEQSEDEDREAKR------KKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPP 185
Query: 274 KKAKEERAPSPPVEVDEP 291
K K +A +P V EP
Sbjct: 186 KPLKTSKAETPTESVSEP 203
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 57.0 bits (136), Expect = 4e-08
Identities = 65/288 (22%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPKQR----PAPAQRLRKK-RTEAPESPCPTGSKPRK 61
T E+ A + E P+ P + P P + +K ++ P+SP K
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 656
Query: 62 PGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEE 121
P + + + S P + +A V + + ++K A E +EEEE
Sbjct: 657 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK----------AEVGKGEQKEEEE 706
Query: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
+E +E +EE EKKE+ P P ++K+ + +KE + K ++V
Sbjct: 707 KEVKEAPKEEKVEKKEE--KPKDVPEKKKAESPVKEEA---------VAEVVTITKSVKV 755
Query: 182 RNKEAPAGEGTKMR--KTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKK 239
++ EG ++ K K+K GE + GS A+ S V K+ ++++
Sbjct: 756 HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 815
Query: 240 GTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
KG+ +EEE+ V + + KG K++E+ + VE
Sbjct: 816 TKEKGSGREEEK----GVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 859
Score = 53.5 bits (127), Expect = 5e-07
Identities = 62/271 (22%), Positives = 108/271 (39%), Gaps = 33/271 (12%)
Query: 19 EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDP 78
EE+ PEA ++ A++ K T APE G K + G +EE +
Sbjct: 493 EEKEEEPEA----EEEEVAAKKSPVKAT-APEVKEEEGEKEEEEG-------QEEEEEED 540
Query: 79 AQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEK 138
A++ Q ++ ++K + + A +E E +EE + +E+ E KE+
Sbjct: 541 EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600
Query: 139 ILLPPKKPLREKSSADLKERRAKAQG-------PRGDLGSPDPPPKPLRVRNKEAPAGEG 191
++ K EK+ + + + + +G P + G P P+ + K
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP----- 655
Query: 192 TKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEE 251
++KG K P A KSP SP ++A K KG +KEEEE
Sbjct: 656 VPKSPVEEKGKSPVSKSPVEEKA---KSPVPK------SPVEEAKSKAEVGKGEQKEEEE 706
Query: 252 EEEAATVIKKSNQKGKAKGKGKKKAKEERAP 282
+E ++ +K + K K + K+ +P
Sbjct: 707 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737
Score = 50.4 bits (119), Expect = 4e-06
Identities = 59/259 (22%), Positives = 109/259 (42%), Gaps = 26/259 (10%)
Query: 97 AKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLK 156
AKK + T + + E EEEE +E+EE+E+E A+ + + K+ EK + +
Sbjct: 508 AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 567
Query: 157 ERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGE----GTKMRKTKK------------K 200
E +A+ + + + K + +++E E K+ K +K K
Sbjct: 568 EGETEAEAEGEEAEAKE--EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 625
Query: 201 GSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIK 260
G K P + + + G+ K +++KG K + EE+A + +
Sbjct: 626 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG--KSPVSKSPVEEKAKSPVP 683
Query: 261 KS---NQKGKAK-GKGKKKAKEER--APSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKK 314
KS K KA+ GKG++K +EE+ +P E E +E + P+ + + +
Sbjct: 684 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 743
Query: 315 GMDRGMYPSYFLHLDTEKK 333
+ S +HL+ E K
Sbjct: 744 AEVVTITKSVKVHLEKETK 762
Score = 47.4 bits (111), Expect = 3e-05
Identities = 51/206 (24%), Positives = 87/206 (42%), Gaps = 27/206 (13%)
Query: 94 DPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSA 153
+PEA++ + +A E +EEE E++EE+ +EE EE+ E K E+ +
Sbjct: 498 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE----GAKSDQAEEGGS 553
Query: 154 DLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSP 213
+ + K +G + + G + E E + +K ++K A K+ +
Sbjct: 554 EKEGSSEKEEGEQEE-GETE--------AEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 604
Query: 214 ASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEE--------EEEAATVIKKSNQK 265
A K A V + ++K K PK +E+ + EE+ + + KS +
Sbjct: 605 AKVEKPEKAKSPVPKSPVEEKG--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 662
Query: 266 GKAKGKGKKKAKEERAPSP----PVE 287
K K K EE+A SP PVE
Sbjct: 663 EKGKSPVSKSPVEEKAKSPVPKSPVE 688
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 1/171 (0%)
Query: 117 EEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP 176
EE EE EDE+ E EE I ++E+ +E+ + + ++ + P
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 513
Query: 177 KPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKAL 236
K KE + + + +++ E K + K ++ GE +
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 237 KKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
+ +G A++E++ EE++ V K AK + +KAK P PVE
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-VPKSPVE 623
Score = 44.7 bits (104), Expect = 2e-04
Identities = 51/228 (22%), Positives = 92/228 (40%), Gaps = 38/228 (16%)
Query: 69 RPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE 128
+P+ E Q + + + + E + + T + + EE++E +E++E
Sbjct: 438 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 497
Query: 129 EEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA 188
E EAEE++ + KK + ++ ++KE + + G + +E
Sbjct: 498 EPEAEEEE----VAAKKSPVKATAPEVKEEEGEKEEEEG--------------QEEEEEE 539
Query: 189 GEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKE 248
EG K + ++ GS +K+ S + EG + +A ++ K +K
Sbjct: 540 DEGAKSDQAEEGGS---EKEGSSEKEEGEQE--------EGETEAEAEGEEAEAKEEKKV 588
Query: 249 EEEEEEAAT-----VIKKSNQKGKAKGKGKKKAKEERAPSP----PVE 287
EE+ EE AT K + KAK K EE+ SP PVE
Sbjct: 589 EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 636
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 57.0 bits (136), Expect = 4e-08
Identities = 65/288 (22%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 7 TLREVWASDSGHEEESLSPEAPRRPKQR----PAPAQRLRKK-RTEAPESPCPTGSKPRK 61
T E+ A + E P+ P + P P + +K ++ P+SP K
Sbjct: 221 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 280
Query: 62 PGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEE 121
P + + + S P + +A V + + ++K A E +EEEE
Sbjct: 281 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK----------AEVGKGEQKEEEE 330
Query: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
+E +E +EE EKKE+ P P ++K+ + +KE + K ++V
Sbjct: 331 KEVKEAPKEEKVEKKEE--KPKDVPEKKKAESPVKEEA---------VAEVVTITKSVKV 379
Query: 182 RNKEAPAGEGTKMR--KTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKK 239
++ EG ++ K K+K GE + GS A+ S V K+ ++++
Sbjct: 380 HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 439
Query: 240 GTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
KG+ +EEE+ V + + KG K++E+ + VE
Sbjct: 440 TKEKGSGREEEK----GVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
Score = 53.5 bits (127), Expect = 5e-07
Identities = 62/271 (22%), Positives = 108/271 (39%), Gaps = 33/271 (12%)
Query: 19 EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDP 78
EE+ PEA ++ A++ K T APE G K + G +EE +
Sbjct: 117 EEKEEEPEA----EEEEVAAKKSPVKAT-APEVKEEEGEKEEEEG-------QEEEEEED 164
Query: 79 AQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEK 138
A++ Q ++ ++K + + A +E E +EE + +E+ E KE+
Sbjct: 165 EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 224
Query: 139 ILLPPKKPLREKSSADLKERRAKAQG-------PRGDLGSPDPPPKPLRVRNKEAPAGEG 191
++ K EK+ + + + + +G P + G P P+ + K
Sbjct: 225 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP----- 279
Query: 192 TKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEE 251
++KG K P A KSP SP ++A K KG +KEEEE
Sbjct: 280 VPKSPVEEKGKSPVSKSPVEEKA---KSPVPK------SPVEEAKSKAEVGKGEQKEEEE 330
Query: 252 EEEAATVIKKSNQKGKAKGKGKKKAKEERAP 282
+E ++ +K + K K + K+ +P
Sbjct: 331 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Score = 50.4 bits (119), Expect = 4e-06
Identities = 59/259 (22%), Positives = 109/259 (42%), Gaps = 26/259 (10%)
Query: 97 AKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLK 156
AKK + T + + E EEEE +E+EE+E+E A+ + + K+ EK + +
Sbjct: 132 AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191
Query: 157 ERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGE----GTKMRKTKK------------K 200
E +A+ + + + K + +++E E K+ K +K K
Sbjct: 192 EGETEAEAEGEEAEAKE--EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 249
Query: 201 GSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIK 260
G K P + + + G+ K +++KG K + EE+A + +
Sbjct: 250 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG--KSPVSKSPVEEKAKSPVP 307
Query: 261 KS---NQKGKAK-GKGKKKAKEER--APSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKK 314
KS K KA+ GKG++K +EE+ +P E E +E + P+ + + +
Sbjct: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
Query: 315 GMDRGMYPSYFLHLDTEKK 333
+ S +HL+ E K
Sbjct: 368 AEVVTITKSVKVHLEKETK 386
Score = 47.4 bits (111), Expect = 3e-05
Identities = 51/206 (24%), Positives = 87/206 (42%), Gaps = 27/206 (13%)
Query: 94 DPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSA 153
+PEA++ + +A E +EEE E++EE+ +EE EE+ E K E+ +
Sbjct: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE----GAKSDQAEEGGS 177
Query: 154 DLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSP 213
+ + K +G + + G + E E + +K ++K A K+ +
Sbjct: 178 EKEGSSEKEEGEQEE-GETE--------AEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 228
Query: 214 ASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEE--------EEEAATVIKKSNQK 265
A K A V + ++K K PK +E+ + EE+ + + KS +
Sbjct: 229 AKVEKPEKAKSPVPKSPVEEKG--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 286
Query: 266 GKAKGKGKKKAKEERAPSP----PVE 287
K K K EE+A SP PVE
Sbjct: 287 EKGKSPVSKSPVEEKAKSPVPKSPVE 312
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 1/171 (0%)
Query: 117 EEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP 176
EE EE EDE+ E EE I ++E+ +E+ + + ++ + P
Sbjct: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
Query: 177 KPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKAL 236
K KE + + + +++ E K + K ++ GE +
Sbjct: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 237 KKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVE 287
+ +G A++E++ EE++ V K AK + +KAK P PVE
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-VPKSPVE 247
Score = 44.7 bits (104), Expect = 2e-04
Identities = 51/228 (22%), Positives = 92/228 (40%), Gaps = 38/228 (16%)
Query: 69 RPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDE 128
+P+ E Q + + + + E + + T + + EE++E +E++E
Sbjct: 62 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 121
Query: 129 EEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPA 188
E EAEE++ + KK + ++ ++KE + + G + +E
Sbjct: 122 EPEAEEEE----VAAKKSPVKATAPEVKEEEGEKEEEEG--------------QEEEEEE 163
Query: 189 GEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKE 248
EG K + ++ GS +K+ S + EG + +A ++ K +K
Sbjct: 164 DEGAKSDQAEEGGS---EKEGSSEKEEGEQE--------EGETEAEAEGEEAEAKEEKKV 212
Query: 249 EEEEEEAAT-----VIKKSNQKGKAKGKGKKKAKEERAPSP----PVE 287
EE+ EE AT K + KAK K EE+ SP PVE
Sbjct: 213 EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 260
>gi|217416343 fibrosin-like 1 [Homo sapiens]
Length = 1045
Score = 56.2 bits (134), Expect = 7e-08
Identities = 66/269 (24%), Positives = 105/269 (39%), Gaps = 31/269 (11%)
Query: 26 EAPRRPKQRPAPAQRLRKKRTEA--------PESPCPTGSKPRKPGAGRTGRPREEPSPD 77
EA RP +R + AQR R +R EA P S P K AG G P +P
Sbjct: 2 EAKVRPSRR-SRAQRDRGRRREAARDARAQSPSSGDEPEPSPGKENAGLRGAPPRGAAPA 60
Query: 78 PAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKE 137
P AR P+ R R+ +++ + + F +A + E E+D + E +EK E
Sbjct: 61 PRTARPPR----RRRRESSSQEEEVIDGFAIA----SFSTLEALEKDMALKPHERKEKWE 112
Query: 138 KILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKT 197
+ L+ + A+ E R + GSP +P ++ P +M+ T
Sbjct: 113 RRLIKKPRESETCPPAEPSENRRPLEA-----GSPGQDLEPACDGARKVPLQPSKQMKVT 167
Query: 198 KKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAAT 257
KG D S A++ + P + D A G E +++A+
Sbjct: 168 VSKGGDRDSDDDSVLEATSSRDPLS---------DSSAHAVSGRGYSCDSESGPDDKASV 218
Query: 258 VIKKSNQKGKAKGKGKKKAKEERAPSPPV 286
+K G KG +K++ + P P V
Sbjct: 219 GSEKLFAPGTDKGPALEKSEAKAGPVPKV 247
Score = 30.4 bits (67), Expect = 4.3
Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 21/131 (16%)
Query: 172 PDPPPKPLRV----------RNKEAPAGEGTKMRKTKKKG---SGEADKDPSGSPASARK 218
P PPP P V ++E G+ + R +K S + P+G P S
Sbjct: 744 PAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLL 803
Query: 219 SPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKE 278
A L G+P +++ P+ +EEAA + +++ G K KE
Sbjct: 804 LRAQSELGRSGAP----AEREAEPRVKESRSPAKEEAAKMPARASPPHSKAAPGDVKVKE 859
Query: 279 ER----APSPP 285
ER A PP
Sbjct: 860 ERGEDEASEPP 870
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 56.2 bits (134), Expect = 7e-08
Identities = 90/401 (22%), Positives = 149/401 (37%), Gaps = 56/401 (13%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTG 68
RE + H ++ P + R Q+ K E P K K R
Sbjct: 846 REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 905
Query: 69 RPREEP----SPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEED 124
R EE +P+ + +R R+P + + ++ V + D +E D
Sbjct: 906 RKGEESEGFLNPELLET-------SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMD 958
Query: 125 EED-------EEEEAEEKKEKILLPPKKPLREKSSADLKERRAK-AQGPRGDL-GSPDPP 175
E E+++ E K K K + S+ KE K A+GP+ + G +
Sbjct: 959 AESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERS 1018
Query: 176 PK---PLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPD 232
P+ P++ +E P K TK S + D+ +G+P A A E P
Sbjct: 1019 PRSEPPIKKAKEETP-----KTDNTKSSSSSQKDEKITGTPRKAHSKSAKEH--QETKPV 1071
Query: 233 KKALKKKGTPKGARKEE--EEEEEAATVIKKSNQKGKA---KGKGKKKAKEERAPSPPVE 287
K+ KK K + E+ +EE+A KK N+K K KG+ +K+ EE+ E
Sbjct: 1072 KEEKVKKDYSKDVKSEKLTTKEEKA----KKPNEKNKPLDNKGEKRKRKTEEKGVDKDFE 1127
Query: 288 VDEPR------EFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRK 341
+ +++P+P + ++ D + MDR KK+ L
Sbjct: 1128 SSSMKISKLEVTEIVKPSP-----KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1182
Query: 342 RKRSKTANYLISIDP------TNLSRGGENFIGKLRSNLLG 376
+K T N + +P T+ E GK+R + G
Sbjct: 1183 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG 1223
Score = 37.0 bits (84), Expect = 0.046
Identities = 37/155 (23%), Positives = 60/155 (38%), Gaps = 4/155 (2%)
Query: 103 RETFLVARAPDAEDEEEEEEEDEEDEEEE---AEEKKEKILLPPKKPLREKSSADLKERR 159
RET A PD + + E ++EE +++ K+KI+ K+ L + + R
Sbjct: 1596 RETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1655
Query: 160 AKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKS 219
++ S P + R+ + A KKK E K K
Sbjct: 1656 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1715
Query: 220 PAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEE 254
A + E S K KKK + K KE+E+E++
Sbjct: 1716 HAGTEVELEKS-QKHKHKKKKSKKNKDKEKEKEKD 1749
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 56.2 bits (134), Expect = 7e-08
Identities = 90/401 (22%), Positives = 149/401 (37%), Gaps = 56/401 (13%)
Query: 9 REVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTG 68
RE + H ++ P + R Q+ K E P K K R
Sbjct: 880 REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 939
Query: 69 RPREEP----SPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEED 124
R EE +P+ + +R R+P + + ++ V + D +E D
Sbjct: 940 RKGEESEGFLNPELLET-------SRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMD 992
Query: 125 EED-------EEEEAEEKKEKILLPPKKPLREKSSADLKERRAK-AQGPRGDL-GSPDPP 175
E E+++ E K K K + S+ KE K A+GP+ + G +
Sbjct: 993 AESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERS 1052
Query: 176 PK---PLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPD 232
P+ P++ +E P K TK S + D+ +G+P A A E P
Sbjct: 1053 PRSEPPIKKAKEETP-----KTDNTKSSSSSQKDEKITGTPRKAHSKSAKEH--QETKPV 1105
Query: 233 KKALKKKGTPKGARKEE--EEEEEAATVIKKSNQKGKA---KGKGKKKAKEERAPSPPVE 287
K+ KK K + E+ +EE+A KK N+K K KG+ +K+ EE+ E
Sbjct: 1106 KEEKVKKDYSKDVKSEKLTTKEEKA----KKPNEKNKPLDNKGEKRKRKTEEKGVDKDFE 1161
Query: 288 VDEPR------EFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRK 341
+ +++P+P + ++ D + MDR KK+ L
Sbjct: 1162 SSSMKISKLEVTEIVKPSP-----KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1216
Query: 342 RKRSKTANYLISIDP------TNLSRGGENFIGKLRSNLLG 376
+K T N + +P T+ E GK+R + G
Sbjct: 1217 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTG 1257
Score = 37.0 bits (84), Expect = 0.046
Identities = 37/155 (23%), Positives = 60/155 (38%), Gaps = 4/155 (2%)
Query: 103 RETFLVARAPDAEDEEEEEEEDEEDEEEE---AEEKKEKILLPPKKPLREKSSADLKERR 159
RET A PD + + E ++EE +++ K+KI+ K+ L + + R
Sbjct: 1630 RETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1689
Query: 160 AKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKS 219
++ S P + R+ + A KKK E K K
Sbjct: 1690 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
Query: 220 PAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEE 254
A + E S K KKK + K KE+E+E++
Sbjct: 1750 HAGTEVELEKS-QKHKHKKKKSKKNKDKEKEKEKD 1783
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/302 (21%), Positives = 104/302 (34%), Gaps = 40/302 (13%)
Query: 14 SDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREE 73
S+ E+ S P P+ P P E+ + S + + + E
Sbjct: 437 SEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENE 496
Query: 74 PSPDPAQARAPQTV-------YARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEE 126
P PA P T + + P A PR T R P+++ + E
Sbjct: 497 PLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEH 556
Query: 127 DEEEEAEEKKEKIL--LPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNK 184
E ++ K PP+ P K S ++ A+ + P+ P KP++
Sbjct: 557 SESKDPPPKSSSKAPRAPPEAPHPGKRSC--QKSPAQQEPPQRQTVGTKQPKKPVKA--- 611
Query: 185 EAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKG 244
A AG T + + +++P P +R + S DK +K KG P+
Sbjct: 612 SARAGSRTSL---------QGEREPGLLPYGSR---------DQTSKDKPKVKTKGRPRA 653
Query: 245 ARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPP---VEVDEPREFVLRPAPQ 301
A E + + S++K K K +K P P VE P F L P +
Sbjct: 654 AASNEPK-----PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTE 708
Query: 302 GR 303
+
Sbjct: 709 SQ 710
Score = 47.0 bits (110), Expect = 4e-05
Identities = 65/298 (21%), Positives = 106/298 (35%), Gaps = 53/298 (17%)
Query: 19 EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR----KPGAGRTGRPREEP 74
+ +++ + P++P + A A + E P GS+ + KP GRPR
Sbjct: 596 QRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAA 655
Query: 75 SPDPAQARAPQT----------VYARFLRDPEAKK-----RDPRETFLV----ARAPDAE 115
S +P A P + ++ L PE K R P LV ++ P
Sbjct: 656 SNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS 715
Query: 116 DEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPP 175
+ + + +K+++ LP R K P D PP
Sbjct: 716 GSGSRTSGCRQAVVVQEDSRKDRLPLPL--------------RDTKLLSPLRDT----PP 757
Query: 176 PKPLRVR-------NKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGE 228
P+ L V+ P G+G++ RK + K K S +S S A GE
Sbjct: 758 PQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGE 817
Query: 229 GSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPV 286
D K + KE + + +++ K + K K + +K+E P PPV
Sbjct: 818 AERDCDNKKIR-----LEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPV 870
Score = 34.7 bits (78), Expect = 0.23
Identities = 41/192 (21%), Positives = 66/192 (34%), Gaps = 20/192 (10%)
Query: 59 PRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPR------------ETF 106
P+ PG G R E+ P PA + + AKKR E
Sbjct: 774 PQPPGKGSRQRKAEDKQP-PAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKE 832
Query: 107 LVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSAD-LKERRAKAQGP 165
+ +++ + +E + + KKE + PP +K + LK R +A
Sbjct: 833 IKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREA--- 889
Query: 166 RGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFL 225
D DPP ++ + K R+ + KGS + + S +A P
Sbjct: 890 --DTCGQDPPKSASSTKSNHKDSSI-PKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLP 946
Query: 226 VGEGSPDKKALK 237
G P K +K
Sbjct: 947 NGNSKPGKPQVK 958
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 54.7 bits (130), Expect = 2e-07
Identities = 71/306 (23%), Positives = 123/306 (40%), Gaps = 52/306 (16%)
Query: 5 DETLREVWASDSG----HEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 60
+ET++ D+G EE++ +P A + + +KK+ E E K +
Sbjct: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK-----EKEK 332
Query: 61 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE 120
K G P A +A Q A+ + E +KR+ E +A+ +EEE
Sbjct: 333 KKG------------PSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
Query: 121 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR 180
E E+ E ++ +EK+ K L + L KS +E RA+A+ K L+
Sbjct: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQ---REARARAEATL----------KLLQ 427
Query: 181 VRNKEAPAGEGTKMRK---TKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALK 237
+ E P+ + ++ KK + S + + + AA+ ++ +G P+K+
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEE-- 485
Query: 238 KKGTPKGARKEEEEEEEAA-----TVIKKSNQKGKAKG-----KGKKKAKEERAPSPPVE 287
TP EEEE+ E A + + K +G + K+ +EE E
Sbjct: 486 ---TPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEE 542
Query: 288 VDEPRE 293
DE E
Sbjct: 543 EDEESE 548
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 10/123 (8%)
Query: 25 PEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAG--RTGRPREEPSPDPAQAR 82
P PK+RP + RKK + ES + S G P +E +P P +
Sbjct: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
Query: 83 APQTVYARFLRDPEAKKRDPRETFL--------VARAPDAEDEEEEEEEDEEDEEEEAEE 134
+ L D EA D + V P+ E+EEEEEEE++E+ EEE EE
Sbjct: 494 EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553
Query: 135 KKE 137
+ E
Sbjct: 554 EGE 556
Score = 40.0 bits (92), Expect = 0.005
Identities = 61/275 (22%), Positives = 102/275 (37%), Gaps = 33/275 (12%)
Query: 31 PKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYAR 90
PK+ AQ+ KK + E + + +G +E S + Q+R Q +
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDE-SDEFLQSRKGQKKNQK 205
Query: 91 FLRDP--EAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEK---KEKILLPPKK 145
P E+ D +F + + E++E E + DEE+ K KE++ K
Sbjct: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD 265
Query: 146 PLREKSSADLKERRAKAQGPRGDLG--------------SPDPPPKPLRVRNKEAPAGEG 191
++K S E D G + D + ++K+ GE
Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325
Query: 192 TKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGE---GSPDKKALKKKGTPKGARKE 248
+ K KKKG PS + A + A E +++ +K+ + RKE
Sbjct: 326 EEKEKEKKKG-------PSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378
Query: 249 EEEEEEAATVIKKSNQ---KGKAKGKGKKKAKEER 280
EE E+ KK + K + K +GK K +R
Sbjct: 379 EERLEQEKRERKKQKEKERKERLKKEGKLLTKSQR 413
Score = 40.0 bits (92), Expect = 0.005
Identities = 55/297 (18%), Positives = 123/297 (41%), Gaps = 30/297 (10%)
Query: 15 DSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEP 74
+SG+E++ S + +++ +R RKKR E K ++ TG+ +
Sbjct: 213 ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL----RKLKEKEELETGKKDQSK 268
Query: 75 SPDPAQARAPQTVYARFLRDPEA--KKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEA 132
+ + +TV ++ D + ET A + D+++++++ ++ E+EE
Sbjct: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
Query: 133 EEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGT 192
E++K+K +++ A LKE + + + + R+ EA E
Sbjct: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQK--------REEEERIKRLEELEAKRKEEE 380
Query: 193 KMRKTKKKGSGEADKD-------------PSGSPASARKSPAAMFLVGEG--SPDKKAL- 236
++ + K++ + +K+ S A AR L +G P K +L
Sbjct: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP 440
Query: 237 KKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE 293
KK+ + ++++ ++ + + +S + A ++ E+ PPVE +E +
Sbjct: 441 KKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEED 497
Score = 37.0 bits (84), Expect = 0.046
Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 15/193 (7%)
Query: 100 RDPRETFLVARAPDAEDEEEEEEEDEEDEEE-EAEEKKEKILLPPKKPLREKSSADLKER 158
++ E L A+ A+ E + E +EEE +++KK+K K+ + S +L+++
Sbjct: 60 KELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDK 119
Query: 159 RAKAQ---GPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPAS 215
+K++ P+ ++ S K+A K +K+ KK G + + +
Sbjct: 120 DSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG----KAQKSNKKWDGSEEDEDNSKKIK 175
Query: 216 ARKSPAAMFLVGEGSPD----KKALKK--KGTPKGARKEEEEEEEAATVIKK-SNQKGKA 268
R + G+ S + +K KK K P + E+++A+ IK + +K +
Sbjct: 176 ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEK 235
Query: 269 KGKGKKKAKEERA 281
K + +KK EE+A
Sbjct: 236 KERERKKRDEEKA 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,172,685
Number of Sequences: 37866
Number of extensions: 1670602
Number of successful extensions: 43171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 814
Number of HSP's successfully gapped in prelim test: 1295
Number of HSP's that attempted gapping in prelim test: 15541
Number of HSP's gapped (non-prelim): 12348
length of query: 542
length of database: 18,247,518
effective HSP length: 107
effective length of query: 435
effective length of database: 14,195,856
effective search space: 6175197360
effective search space used: 6175197360
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.