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Search of human proteins with 157266328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 1584 0.0
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 133 7e-31
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 133 7e-31
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 125 1e-28
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 105 1e-22
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 105 1e-22
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 105 1e-22
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 103 8e-22
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 95 3e-19
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 93 8e-19
gi|188219549 ankyrin repeat domain 32 [Homo sapiens] 92 2e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 91 4e-18
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 91 4e-18
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 91 4e-18
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 91 4e-18
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 91 4e-18
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens] 87 6e-17
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens] 87 6e-17
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens] 87 6e-17
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens] 87 8e-17
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 82 2e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 80 7e-15
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 80 9e-15
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 79 1e-14
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 78 4e-14
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 78 4e-14
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 78 4e-14
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 77 5e-14
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 76 1e-13
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] 75 3e-13
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 1584 bits (4101), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 60
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
Sbjct: 1 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 60
Query: 61 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL 120
VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
Sbjct: 61 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL 120
Query: 121 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY 180
SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
Sbjct: 121 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY 180
Query: 181 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV 240
EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
Sbjct: 181 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV 240
Query: 241 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP 300
SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
Sbjct: 241 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP 300
Query: 301 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP 360
EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
Sbjct: 301 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP 360
Query: 361 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM 420
ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
Sbjct: 361 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM 420
Query: 421 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 480
AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
Sbjct: 421 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 480
Query: 481 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK 540
LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
Sbjct: 481 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK 540
Query: 541 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF 600
SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
Sbjct: 541 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF 600
Query: 601 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS 660
DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
Sbjct: 601 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS 660
Query: 661 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV 720
RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
Sbjct: 661 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV 720
Query: 721 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 777
AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
Sbjct: 721 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 777
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 133 bits (334), Expect = 7e-31
Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 1/153 (0%)
Query: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450
SP + P+ S ++ + +PS+ + KRN RGET LH+A+I+GD+ V+ L+
Sbjct: 126 SPDSTPNHPSQTTPAQ-KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISL 184
Query: 451 GSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIV 510
G++ NVKD AGWTPLHEACN G+ V ++L+ A VNT G +D+PLHD+A +GH DIV
Sbjct: 185 GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIV 244
Query: 511 KLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
KLLL +G + N G RPVD + E ++ LL
Sbjct: 245 KLLLRHGGNPFQANKHGERPVDVAETEELELLL 277
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 133 bits (334), Expect = 7e-31
Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 1/153 (0%)
Query: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450
SP + P+ S ++ + +PS+ + KRN RGET LH+A+I+GD+ V+ L+
Sbjct: 149 SPDSTPNHPSQTTPAQ-KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISL 207
Query: 451 GSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIV 510
G++ NVKD AGWTPLHEACN G+ V ++L+ A VNT G +D+PLHD+A +GH DIV
Sbjct: 208 GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIV 267
Query: 511 KLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
KLLL +G + N G RPVD + E ++ LL
Sbjct: 268 KLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 125 bits (315), Expect = 1e-28
Identities = 73/186 (39%), Positives = 100/186 (53%), Gaps = 3/186 (1%)
Query: 410 SPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEAC 469
+P++ + KRN RGET LH A+I+GD ++ L+ G+D NVKD AGWT LHEAC
Sbjct: 150 TPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEAC 209
Query: 470 NHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLR 529
N G+ V + LL A VNT G +D+PLHDAA NGH +VKLLL YG + N G
Sbjct: 210 NRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGET 269
Query: 530 PVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELA 589
P+ + +M +LLL + ++S S + + D P S + E
Sbjct: 270 PLKVANSPTMVNLLL---GKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKG 326
Query: 590 VILKAK 595
+ KAK
Sbjct: 327 LKHKAK 332
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 105 bits (263), Expect = 1e-22
Identities = 62/162 (38%), Positives = 88/162 (54%), Gaps = 9/162 (5%)
Query: 382 NMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDI 441
NMS E ++S LS + + P N KRN RGE+ LH+A +G++
Sbjct: 1118 NMSKELANISK------LSQREKKEISHKPGMKAGRIN---KRNARGESQLHLAVRRGNL 1168
Query: 442 PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501
P V+ L+++G+D N+ D+AGWTPLHEA N G + ++ LL+ A VN PLHDA
Sbjct: 1169 PLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDA 1228
Query: 502 AKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N H+ ++LL GA+ N + +D DDE MK LL
Sbjct: 1229 VANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
Score = 76.3 bits (186), Expect = 1e-13
Identities = 46/121 (38%), Positives = 62/121 (51%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+RN GE L++ A++ D V + ++ G + N +AGWT LHEA G + LL+
Sbjct: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542
A VN G +PLHDA NGH + +LLL GA N G +D D MK L
Sbjct: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRL 603
Query: 543 L 543
L
Sbjct: 604 L 604
Score = 30.0 bits (66), Expect = 8.6
Identities = 15/58 (25%), Positives = 29/58 (50%)
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
+N + +S LH A + G++ +VK L+ GA N + G P+ +E +++
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 105 bits (263), Expect = 1e-22
Identities = 62/162 (38%), Positives = 88/162 (54%), Gaps = 9/162 (5%)
Query: 382 NMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDI 441
NMS E ++S LS + + P N KRN RGE+ LH+A +G++
Sbjct: 1118 NMSKELANISK------LSQREKKEISHKPGMKAGRIN---KRNARGESQLHLAVRRGNL 1168
Query: 442 PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501
P V+ L+++G+D N+ D+AGWTPLHEA N G + ++ LL+ A VN PLHDA
Sbjct: 1169 PLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDA 1228
Query: 502 AKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N H+ ++LL GA+ N + +D DDE MK LL
Sbjct: 1229 VANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
Score = 76.3 bits (186), Expect = 1e-13
Identities = 46/121 (38%), Positives = 62/121 (51%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+RN GE L++ A++ D V + ++ G + N +AGWT LHEA G + LL+
Sbjct: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542
A VN G +PLHDA NGH + +LLL GA N G +D D MK L
Sbjct: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRL 603
Query: 543 L 543
L
Sbjct: 604 L 604
Score = 30.0 bits (66), Expect = 8.6
Identities = 15/58 (25%), Positives = 29/58 (50%)
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
+N + +S LH A + G++ +VK L+ GA N + G P+ +E +++
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 105 bits (263), Expect = 1e-22
Identities = 62/162 (38%), Positives = 88/162 (54%), Gaps = 9/162 (5%)
Query: 382 NMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDI 441
NMS E ++S LS + + P N KRN RGE+ LH+A +G++
Sbjct: 1118 NMSKELANISK------LSQREKKEISHKPGMKAGRIN---KRNARGESQLHLAVRRGNL 1168
Query: 442 PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501
P V+ L+++G+D N+ D+AGWTPLHEA N G + ++ LL+ A VN PLHDA
Sbjct: 1169 PLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDA 1228
Query: 502 AKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N H+ ++LL GA+ N + +D DDE MK LL
Sbjct: 1229 VANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
Score = 76.3 bits (186), Expect = 1e-13
Identities = 46/121 (38%), Positives = 62/121 (51%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+RN GE L++ A++ D V + ++ G + N +AGWT LHEA G + LL+
Sbjct: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542
A VN G +PLHDA NGH + +LLL GA N G +D D MK L
Sbjct: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRL 603
Query: 543 L 543
L
Sbjct: 604 L 604
Score = 30.0 bits (66), Expect = 8.6
Identities = 15/58 (25%), Positives = 29/58 (50%)
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
+N + +S LH A + G++ +VK L+ GA N + G P+ +E +++
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 103 bits (256), Expect = 8e-22
Identities = 53/113 (46%), Positives = 71/113 (62%), Gaps = 3/113 (2%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+RN GETLLH A I+G + V+ L++ G N +D+ GWTPLHEACN+GHL++V LL
Sbjct: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
Query: 483 HKALVNTTGYQ---NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD 532
H A V+ G Q +PLHDA GH ++ +LLL GAS GL P++
Sbjct: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/71 (38%), Positives = 42/71 (59%)
Query: 449 QNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVD 508
+ GS N ++ G T LH AC G L+ V+ L++ +N Y +PLH+A GH++
Sbjct: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
Query: 509 IVKLLLSYGAS 519
IV+ LL +GA+
Sbjct: 577 IVRFLLDHGAA 587
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 94.7 bits (234), Expect = 3e-19
Identities = 49/110 (44%), Positives = 65/110 (59%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH A+ + VEYLLQ+G+D + KD G PLH AC++GH +V ELL++H A+
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDD 536
VN +PLH+AA G +I KLLL +GA N G P+D D
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD 634
Score = 89.0 bits (219), Expect = 2e-17
Identities = 47/125 (37%), Positives = 66/125 (52%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH+A+ + V+ LLQ+G+D + KD PLH AC++GH +V ELL++H A
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
VN +PLH+AA V++ LLLSYGA +N +D +K L
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329
Query: 547 EKNES 551
K S
Sbjct: 330 FKGHS 334
Score = 88.2 bits (217), Expect = 3e-17
Identities = 45/117 (38%), Positives = 68/117 (58%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH+A+ ++ EYLLQ+G+D N +D G PLH A ++GH+ V LL+++ A
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
VN T +PLH+AA+ G + LLL++GA N G P+D + + +LL
Sbjct: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 85.5 bits (210), Expect = 2e-16
Identities = 50/117 (42%), Positives = 66/117 (56%), Gaps = 1/117 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH A+ G VEYLLQNG++ +D G PLH AC+ GH +VV LLL+H A
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGAD 116
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N N +PLH+AA G +D+ +LL +GA N G +D D S K++L
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-DPSAKAVL 172
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/119 (35%), Positives = 62/119 (52%), Gaps = 6/119 (5%)
Query: 429 ETLLHIASIKGDIPS----VEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
ET LH A+ P E LL+ G++ N K TPLH A H VVE++++H+
Sbjct: 365 ETALHCAAAS-PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
A VN + LH AA GH+ +LLLSYG N +++ G + +E+++ LL
Sbjct: 424 AKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ-MGNENVQQLL 481
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/162 (25%), Positives = 69/162 (42%), Gaps = 54/162 (33%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAG---------------------- 461
R++ T LH A+IKG I LLQ+G++P +++ G
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKD 179
Query: 462 -----------------WTPLHEACN---------------HGHLKVVELLLQHKALVNT 489
TPL+ C+ + +K+V+LLLQH A V+
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ PLH+A GH ++ +LL+ +GA NA++++ P+
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R+ G LH A G V LL++G+DPN +D+ +TPLHEA G + V +LLQH
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Query: 484 KA---LVNTTG 491
A + NT G
Sbjct: 147 GAEPTIRNTDG 157
Score = 43.5 bits (101), Expect = 7e-04
Identities = 52/231 (22%), Positives = 83/231 (35%), Gaps = 70/231 (30%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLH--------------------- 466
G+T LH A+ G + + LL G DPN+ G+T L
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEA 492
Query: 467 -----EACNHGHLKVV----------------------------------ELLLQHKALV 487
EA G ++ V E LLQH A V
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPE 547
+ PLH+A GH ++ +LL+ +GA N +++ P+ + + L
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 548 KNESSSASHCSVMNTGQRRDG--PLVLIGSGLSSEQQKMLSELAVILKAKK 596
++ + T + RDG PL L+ G + Q + + A++ AKK
Sbjct: 613 QHGADP--------TKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Score = 38.1 bits (87), Expect = 0.031
Identities = 25/68 (36%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 465 LHEACNHGHL-KVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAV 523
L EAC +G + +V L+ K T + +PLH AA G D+V+ LL GA+ A
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 524 NIFGLRPV 531
+ GL P+
Sbjct: 88 DDGGLIPL 95
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 93.2 bits (230), Expect = 8e-19
Identities = 50/125 (40%), Positives = 68/125 (54%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH+A+ + V+ LLQ+G+D + KD G PLH AC++GH +V ELLL+H A
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
VN +PLH+AA V++ LLLS+GA VN G VD ++ L
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
Query: 547 EKNES 551
K S
Sbjct: 488 FKGHS 492
Score = 90.9 bits (224), Expect = 4e-18
Identities = 60/177 (33%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 364 SPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSA-MKLLPNMAV 422
S PS G T+ + + + +S S P S YR + +S + ++ + +
Sbjct: 615 SDPSIISLQGFTAAQMGNEAVQQILSEST---PIRTSDVDYRLLEASKAGDLETVKQLCS 671
Query: 423 KRN-------HRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLK 475
+N R T LH A+ + VEYLL +G+D + KD G PLH AC++GH +
Sbjct: 672 SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 731
Query: 476 VVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD 532
V ELL++H A VN +PLH+AA G +I KLLL +GA N G P+D
Sbjct: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
Score = 87.0 bits (214), Expect = 6e-17
Identities = 42/118 (35%), Positives = 69/118 (58%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R T LH+A+ ++ EYLL++G+D N +D G PLH A ++GH+ + LL+++
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
VN T +PLH+AA+ G + LLL++GA N G P+D + +++LL+
Sbjct: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLI 953
Score = 77.4 bits (189), Expect = 5e-14
Identities = 48/129 (37%), Positives = 68/129 (52%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
R + LH A+ G VE+LLQ G++ + +D G PLH AC+ GH +VV LLL A
Sbjct: 215 RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD 274
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N N +PLH+AA G +D+ +LL +GA N N G +D D + L
Sbjct: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEY 334
Query: 547 EKNESSSAS 555
+K+E A+
Sbjct: 335 KKDELLEAA 343
Score = 60.8 bits (146), Expect = 5e-09
Identities = 39/108 (36%), Positives = 58/108 (53%), Gaps = 3/108 (2%)
Query: 423 KRNHRGETLLH--IASIKGDIPSV-EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVEL 479
K+ ET LH +AS+ V E LL+ G++ N K+ TPLH A H V+E+
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
Query: 480 LLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
L +H A +N + LH AA GH+ +LLLSYG+ + +++ G
Sbjct: 577 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG 624
Score = 50.1 bits (118), Expect = 8e-06
Identities = 49/162 (30%), Positives = 64/162 (39%), Gaps = 54/162 (33%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R+ G LH A G V LL G+DPN +D+ +TPLHEA G + V +LLQH
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 484 KA---LVNTTG------------------YQND--------------------------- 495
A + NT G Y+ D
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
Query: 496 ------SPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+PLH AA V IV+LLL +GA +A + GL P+
Sbjct: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
Score = 47.0 bits (110), Expect = 7e-05
Identities = 54/231 (23%), Positives = 85/231 (36%), Gaps = 70/231 (30%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTP----------------------- 464
G+T LH A++ G + + LL GSDP++ G+T
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDV 650
Query: 465 ---LHEACNHGHLKVV----------------------------------ELLLQHKALV 487
L EA G L+ V E LL H A V
Sbjct: 651 DYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADV 710
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPE 547
+ PLH+A GH ++ +LL+ +GAS N +++ P+ + + L
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 548 KNESSSASHCSVMNTGQRRDG--PLVLIGSGLSSEQQKMLSELAVILKAKK 596
K+ + T + RDG PL L+ G + Q + + A++ AKK
Sbjct: 771 KHGADP--------TKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813
>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
Length = 1058
Score = 91.7 bits (226), Expect = 2e-18
Identities = 60/137 (43%), Positives = 75/137 (54%), Gaps = 10/137 (7%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQ-NGSDPNVKDHAGWTPLHEACNHGHLKVVELLL 481
K N +GET LH A I + + LL G D NVKD+AGWTPLHEACN+G+ V+ +L
Sbjct: 802 KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEIL 861
Query: 482 QHKALVN-TTGYQNDSPLHDAAKNGHVDIVKLLLSYGA-----SRNAVNIFGLRPVDYTD 535
Q V+ T +PLHDA NGHV+I KLLL +G RNA G P+DY
Sbjct: 862 QRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAK---GELPLDYVV 918
Query: 536 DESMKSLLLLPEKNESS 552
+K L K E +
Sbjct: 919 SPQIKEELFAITKIEDT 935
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 90.9 bits (224), Expect = 4e-18
Identities = 53/127 (41%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G +P V+ LLQ G+ PNV + TPLH A GH +V + LLQ+KA V
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES-MKSLLLLP 546
N + +PLH AA+ GH ++VKLLL A+ N G P+ E ++++L L
Sbjct: 497 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
Query: 547 EKNESSS 553
EK S +
Sbjct: 557 EKEASQA 563
Score = 88.2 bits (217), Expect = 3e-17
Identities = 46/107 (42%), Positives = 66/107 (61%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+ + +G +P + L+++G + G+TPLH A ++G++K+V+ LLQH+
Sbjct: 698 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN SPLH AA+ GH DIV LLL GAS N V+ G P+
Sbjct: 758 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Score = 80.5 bits (197), Expect = 6e-15
Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 11/210 (5%)
Query: 347 FVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKN--SNMSDEFISLSPGTPPSTLSSSSY 404
++ Q N + +P C ++G T+ K N ++ ++ + G P +++
Sbjct: 488 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA--- 544
Query: 405 RRVMSSPSAMKLLPNMAVKR--NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGW 462
R + + LL A + +G T LH+A+ G + E LL+ + PN G
Sbjct: 545 -REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603
Query: 463 TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
TPLH A +H +L +V+LLL ++ + +PLH AAK V++ + LL YG S NA
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 523 VNIFGLRPVDYTDDE---SMKSLLLLPEKN 549
++ G+ P+ E M +LLL + N
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/104 (38%), Positives = 58/104 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIAS +G++ V LL G+ K TPLH A +GH+++ E+LL H A +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
SP+H AA+ H+D V+LLL Y A + + + L P+
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
Score = 73.2 bits (178), Expect = 9e-13
Identities = 40/126 (31%), Positives = 67/126 (53%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ +G V LL ++ N+ + +G TPLH GH+ V ++L++H +
Sbjct: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
V+ T +PLH A+ G++ +VK LL + A NA G P+ + ++ L
Sbjct: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Query: 547 EKNESS 552
KN +S
Sbjct: 787 LKNGAS 792
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/138 (36%), Positives = 70/138 (50%), Gaps = 9/138 (6%)
Query: 388 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHR---GETLLHIASIKGDIPSV 444
I+L TP + + RV K+L + K N R G T LHIA K + +
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVA------KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 445 EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKN 504
E LL+ G+ + +G TPLH A GHL +V+ LLQ A N + + ++PLH AA+
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
Query: 505 GHVDIVKLLLSYGASRNA 522
GH ++ K LL A NA
Sbjct: 481 GHTEVAKYLLQNKAKVNA 498
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/96 (41%), Positives = 56/96 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL G+ PN + G+TPLH AC H++V+ELLL+ A ++
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNI 525
+PLH A+ GH+ IVK LL GAS N N+
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 468
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN A K G T LH+A ++ V+ LL G P+ G+TPLH A ++V
Sbjct: 595 PNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LLQ+ N Q +PLH AA+ GH ++V LLLS A+ N N GL P+ E
Sbjct: 652 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 711
Score = 70.1 bits (170), Expect = 7e-12
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN++ N + ET LH+A+ G +YLLQN + N K TPLH A GH +V
Sbjct: 463 PNVS---NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+LLL++ A N +PLH AA+ GHV+ V LL AS+ + G P+
Sbjct: 520 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/87 (43%), Positives = 53/87 (60%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ D + LLQN +P+V G+TPLH A ++ +L V +LLL A VN T
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
+PLH A++ G+V +V+LLL GA
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGA 296
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/104 (39%), Positives = 56/104 (53%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ ++ + LL G+ N G TPLH A G++ +V LLL A +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
T +PLH AA+NGHV I ++LL +GA A GL P+
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/123 (32%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LHIA++ G V L+ G++ N + G+TPL+ A HL+VV+ LL++ A
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N +PL A + GH ++V L++YG ++ V + L DD ++LL
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARNDDTRTAAVLLQN 228
Query: 547 EKN 549
+ N
Sbjct: 229 DPN 231
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 52/104 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ + + LLQ G N + G TPLH A GH ++V LLL +A
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH A+ GHV + +L+ +G +A G P+
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/86 (38%), Positives = 51/86 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G+I V++LLQ+ +D N K G++PLH+A GH +V LLL++ A
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
N +PL A + G++ + +L
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 53/102 (51%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH A+ G + E LL +G+ K G +P+H A HL V LLLQ+ A ++
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH AA GH + K+LL GA N+ + G P+
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 408
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS--DPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ G + +H+A+ + V LLQ + D DH TPLH A + GH +V ++LL
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLL 391
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N+ +PLH A K HV +++LLL GAS +AV GL P+
Sbjct: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/97 (34%), Positives = 54/97 (55%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
A+ G++ L+NG D N + G LH A GH+K+V LL + ++ TT +
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
++ LH AA G ++V+ L++YGA+ NA + G P+
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 148
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/107 (33%), Positives = 52/107 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LL G T LH A G +VV L+ +
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN + +PL+ AA+ H+++VK LL GA++N G P+
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 181
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ +G T L++A+ + + V++LL+NG++ NV G+TPL A GH VV L+ +
Sbjct: 140 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Query: 484 --KALVNTTGY----------------QND-----------SPLHDAAKNGHVDIVKLLL 514
K V QND +PLH AA ++++ +LLL
Sbjct: 200 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259
Query: 515 SYGASRNAVNIFGLRPV 531
+ GAS N G+ P+
Sbjct: 260 NRGASVNFTPQNGITPL 276
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 90.9 bits (224), Expect = 4e-18
Identities = 53/127 (41%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G +P V+ LLQ G+ PNV + TPLH A GH +V + LLQ+KA V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES-MKSLLLLP 546
N + +PLH AA+ GH ++VKLLL A+ N G P+ E ++++L L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Query: 547 EKNESSS 553
EK S +
Sbjct: 524 EKEASQA 530
Score = 88.2 bits (217), Expect = 3e-17
Identities = 46/107 (42%), Positives = 66/107 (61%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+ + +G +P + L+++G + G+TPLH A ++G++K+V+ LLQH+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN SPLH AA+ GH DIV LLL GAS N V+ G P+
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 80.5 bits (197), Expect = 6e-15
Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 11/210 (5%)
Query: 347 FVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKN--SNMSDEFISLSPGTPPSTLSSSSY 404
++ Q N + +P C ++G T+ K N ++ ++ + G P +++
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA--- 511
Query: 405 RRVMSSPSAMKLLPNMAVKR--NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGW 462
R + + LL A + +G T LH+A+ G + E LL+ + PN G
Sbjct: 512 -REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 463 TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
TPLH A +H +L +V+LLL ++ + +PLH AAK V++ + LL YG S NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 523 VNIFGLRPVDYTDDE---SMKSLLLLPEKN 549
++ G+ P+ E M +LLL + N
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/104 (38%), Positives = 58/104 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIAS +G++ V LL G+ K TPLH A +GH+++ E+LL H A +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
SP+H AA+ H+D V+LLL Y A + + + L P+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Score = 73.2 bits (178), Expect = 9e-13
Identities = 40/126 (31%), Positives = 67/126 (53%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ +G V LL ++ N+ + +G TPLH GH+ V ++L++H +
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
V+ T +PLH A+ G++ +VK LL + A NA G P+ + ++ L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 547 EKNESS 552
KN +S
Sbjct: 754 LKNGAS 759
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/138 (36%), Positives = 70/138 (50%), Gaps = 9/138 (6%)
Query: 388 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHR---GETLLHIASIKGDIPSV 444
I+L TP + + RV K+L + K N R G T LHIA K + +
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVA------KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 445 EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKN 504
E LL+ G+ + +G TPLH A GHL +V+ LLQ A N + + ++PLH AA+
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 505 GHVDIVKLLLSYGASRNA 522
GH ++ K LL A NA
Sbjct: 448 GHTEVAKYLLQNKAKVNA 465
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/96 (41%), Positives = 56/96 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL G+ PN + G+TPLH AC H++V+ELLL+ A ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNI 525
+PLH A+ GH+ IVK LL GAS N N+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN A K G T LH+A ++ V+ LL G P+ G+TPLH A ++V
Sbjct: 562 PNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LLQ+ N Q +PLH AA+ GH ++V LLLS A+ N N GL P+ E
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Score = 70.1 bits (170), Expect = 7e-12
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN++ N + ET LH+A+ G +YLLQN + N K TPLH A GH +V
Sbjct: 430 PNVS---NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+LLL++ A N +PLH AA+ GHV+ V LL AS+ + G P+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/87 (43%), Positives = 53/87 (60%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ D + LLQN +P+V G+TPLH A ++ +L V +LLL A VN T
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
+PLH A++ G+V +V+LLL GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA 263
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/104 (39%), Positives = 56/104 (53%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ ++ + LL G+ N G TPLH A G++ +V LLL A +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
T +PLH AA+NGHV I ++LL +GA A GL P+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/123 (32%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LHIA++ G V L+ G++ N + G+TPL+ A HL+VV+ LL++ A
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N +PL A + GH ++V L++YG ++ V + L DD ++LL
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 547 EKN 549
+ N
Sbjct: 196 DPN 198
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 52/104 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ + + LLQ G N + G TPLH A GH ++V LLL +A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH A+ GHV + +L+ +G +A G P+
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/86 (38%), Positives = 51/86 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G+I V++LLQ+ +D N K G++PLH+A GH +V LLL++ A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
N +PL A + G++ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 53/102 (51%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH A+ G + E LL +G+ K G +P+H A HL V LLLQ+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH AA GH + K+LL GA N+ + G P+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS--DPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ G + +H+A+ + V LLQ + D DH TPLH A + GH +V ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLL 358
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N+ +PLH A K HV +++LLL GAS +AV GL P+
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/97 (34%), Positives = 54/97 (55%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
A+ G++ L+NG D N + G LH A GH+K+V LL + ++ TT +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
++ LH AA G ++V+ L++YGA+ NA + G P+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/107 (33%), Positives = 52/107 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LL G T LH A G +VV L+ +
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN + +PL+ AA+ H+++VK LL GA++N G P+
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ +G T L++A+ + + V++LL+NG++ NV G+TPL A GH VV L+ +
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 484 --KALVNTTGY----------------QND-----------SPLHDAAKNGHVDIVKLLL 514
K V QND +PLH AA ++++ +LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 515 SYGASRNAVNIFGLRPV 531
+ GAS N G+ P+
Sbjct: 227 NRGASVNFTPQNGITPL 243
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 90.9 bits (224), Expect = 4e-18
Identities = 53/127 (41%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G +P V+ LLQ G+ PNV + TPLH A GH +V + LLQ+KA V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES-MKSLLLLP 546
N + +PLH AA+ GH ++VKLLL A+ N G P+ E ++++L L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Query: 547 EKNESSS 553
EK S +
Sbjct: 524 EKEASQA 530
Score = 88.2 bits (217), Expect = 3e-17
Identities = 46/107 (42%), Positives = 66/107 (61%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+ + +G +P + L+++G + G+TPLH A ++G++K+V+ LLQH+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN SPLH AA+ GH DIV LLL GAS N V+ G P+
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 80.5 bits (197), Expect = 6e-15
Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 11/210 (5%)
Query: 347 FVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKN--SNMSDEFISLSPGTPPSTLSSSSY 404
++ Q N + +P C ++G T+ K N ++ ++ + G P +++
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA--- 511
Query: 405 RRVMSSPSAMKLLPNMAVKR--NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGW 462
R + + LL A + +G T LH+A+ G + E LL+ + PN G
Sbjct: 512 -REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 463 TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
TPLH A +H +L +V+LLL ++ + +PLH AAK V++ + LL YG S NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 523 VNIFGLRPVDYTDDE---SMKSLLLLPEKN 549
++ G+ P+ E M +LLL + N
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/104 (38%), Positives = 58/104 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIAS +G++ V LL G+ K TPLH A +GH+++ E+LL H A +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
SP+H AA+ H+D V+LLL Y A + + + L P+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Score = 73.2 bits (178), Expect = 9e-13
Identities = 40/126 (31%), Positives = 67/126 (53%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ +G V LL ++ N+ + +G TPLH GH+ V ++L++H +
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
V+ T +PLH A+ G++ +VK LL + A NA G P+ + ++ L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 547 EKNESS 552
KN +S
Sbjct: 754 LKNGAS 759
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/138 (36%), Positives = 70/138 (50%), Gaps = 9/138 (6%)
Query: 388 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHR---GETLLHIASIKGDIPSV 444
I+L TP + + RV K+L + K N R G T LHIA K + +
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVA------KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 445 EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKN 504
E LL+ G+ + +G TPLH A GHL +V+ LLQ A N + + ++PLH AA+
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 505 GHVDIVKLLLSYGASRNA 522
GH ++ K LL A NA
Sbjct: 448 GHTEVAKYLLQNKAKVNA 465
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/96 (41%), Positives = 56/96 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL G+ PN + G+TPLH AC H++V+ELLL+ A ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNI 525
+PLH A+ GH+ IVK LL GAS N N+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN A K G T LH+A ++ V+ LL G P+ G+TPLH A ++V
Sbjct: 562 PNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LLQ+ N Q +PLH AA+ GH ++V LLLS A+ N N GL P+ E
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Score = 70.1 bits (170), Expect = 7e-12
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN++ N + ET LH+A+ G +YLLQN + N K TPLH A GH +V
Sbjct: 430 PNVS---NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+LLL++ A N +PLH AA+ GHV+ V LL AS+ + G P+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/87 (43%), Positives = 53/87 (60%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ D + LLQN +P+V G+TPLH A ++ +L V +LLL A VN T
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
+PLH A++ G+V +V+LLL GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA 263
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/104 (39%), Positives = 56/104 (53%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ ++ + LL G+ N G TPLH A G++ +V LLL A +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
T +PLH AA+NGHV I ++LL +GA A GL P+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/123 (32%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LHIA++ G V L+ G++ N + G+TPL+ A HL+VV+ LL++ A
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N +PL A + GH ++V L++YG ++ V + L DD ++LL
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 547 EKN 549
+ N
Sbjct: 196 DPN 198
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 52/104 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ + + LLQ G N + G TPLH A GH ++V LLL +A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH A+ GHV + +L+ +G +A G P+
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/86 (38%), Positives = 51/86 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G+I V++LLQ+ +D N K G++PLH+A GH +V LLL++ A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
N +PL A + G++ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 53/102 (51%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH A+ G + E LL +G+ K G +P+H A HL V LLLQ+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH AA GH + K+LL GA N+ + G P+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS--DPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ G + +H+A+ + V LLQ + D DH TPLH A + GH +V ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLL 358
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N+ +PLH A K HV +++LLL GAS +AV GL P+
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/97 (34%), Positives = 54/97 (55%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
A+ G++ L+NG D N + G LH A GH+K+V LL + ++ TT +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
++ LH AA G ++V+ L++YGA+ NA + G P+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/107 (33%), Positives = 52/107 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LL G T LH A G +VV L+ +
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN + +PL+ AA+ H+++VK LL GA++N G P+
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ +G T L++A+ + + V++LL+NG++ NV G+TPL A GH VV L+ +
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 484 --KALVNTTGY----------------QND-----------SPLHDAAKNGHVDIVKLLL 514
K V QND +PLH AA ++++ +LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 515 SYGASRNAVNIFGLRPV 531
+ GAS N G+ P+
Sbjct: 227 NRGASVNFTPQNGITPL 243
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 90.9 bits (224), Expect = 4e-18
Identities = 53/127 (41%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G +P V+ LLQ G+ PNV + TPLH A GH +V + LLQ+KA V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES-MKSLLLLP 546
N + +PLH AA+ GH ++VKLLL A+ N G P+ E ++++L L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Query: 547 EKNESSS 553
EK S +
Sbjct: 524 EKEASQA 530
Score = 88.2 bits (217), Expect = 3e-17
Identities = 46/107 (42%), Positives = 66/107 (61%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+ + +G +P + L+++G + G+TPLH A ++G++K+V+ LLQH+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN SPLH AA+ GH DIV LLL GAS N V+ G P+
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 80.5 bits (197), Expect = 6e-15
Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 11/210 (5%)
Query: 347 FVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKN--SNMSDEFISLSPGTPPSTLSSSSY 404
++ Q N + +P C ++G T+ K N ++ ++ + G P +++
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA--- 511
Query: 405 RRVMSSPSAMKLLPNMAVKR--NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGW 462
R + + LL A + +G T LH+A+ G + E LL+ + PN G
Sbjct: 512 -REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 463 TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
TPLH A +H +L +V+LLL ++ + +PLH AAK V++ + LL YG S NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 523 VNIFGLRPVDYTDDE---SMKSLLLLPEKN 549
++ G+ P+ E M +LLL + N
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/104 (38%), Positives = 58/104 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIAS +G++ V LL G+ K TPLH A +GH+++ E+LL H A +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
SP+H AA+ H+D V+LLL Y A + + + L P+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Score = 73.2 bits (178), Expect = 9e-13
Identities = 40/126 (31%), Positives = 67/126 (53%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ +G V LL ++ N+ + +G TPLH GH+ V ++L++H +
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
V+ T +PLH A+ G++ +VK LL + A NA G P+ + ++ L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 547 EKNESS 552
KN +S
Sbjct: 754 LKNGAS 759
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/138 (36%), Positives = 70/138 (50%), Gaps = 9/138 (6%)
Query: 388 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHR---GETLLHIASIKGDIPSV 444
I+L TP + + RV K+L + K N R G T LHIA K + +
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVA------KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 445 EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKN 504
E LL+ G+ + +G TPLH A GHL +V+ LLQ A N + + ++PLH AA+
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 505 GHVDIVKLLLSYGASRNA 522
GH ++ K LL A NA
Sbjct: 448 GHTEVAKYLLQNKAKVNA 465
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/96 (41%), Positives = 56/96 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL G+ PN + G+TPLH AC H++V+ELLL+ A ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNI 525
+PLH A+ GH+ IVK LL GAS N N+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN A K G T LH+A ++ V+ LL G P+ G+TPLH A ++V
Sbjct: 562 PNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LLQ+ N Q +PLH AA+ GH ++V LLLS A+ N N GL P+ E
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Score = 70.1 bits (170), Expect = 7e-12
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN++ N + ET LH+A+ G +YLLQN + N K TPLH A GH +V
Sbjct: 430 PNVS---NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+LLL++ A N +PLH AA+ GHV+ V LL AS+ + G P+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/87 (43%), Positives = 53/87 (60%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ D + LLQN +P+V G+TPLH A ++ +L V +LLL A VN T
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
+PLH A++ G+V +V+LLL GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA 263
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/104 (39%), Positives = 56/104 (53%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ ++ + LL G+ N G TPLH A G++ +V LLL A +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
T +PLH AA+NGHV I ++LL +GA A GL P+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/123 (32%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LHIA++ G V L+ G++ N + G+TPL+ A HL+VV+ LL++ A
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N +PL A + GH ++V L++YG ++ V + L DD ++LL
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 547 EKN 549
+ N
Sbjct: 196 DPN 198
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 52/104 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ + + LLQ G N + G TPLH A GH ++V LLL +A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH A+ GHV + +L+ +G +A G P+
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/86 (38%), Positives = 51/86 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G+I V++LLQ+ +D N K G++PLH+A GH +V LLL++ A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
N +PL A + G++ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 53/102 (51%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH A+ G + E LL +G+ K G +P+H A HL V LLLQ+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH AA GH + K+LL GA N+ + G P+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS--DPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ G + +H+A+ + V LLQ + D DH TPLH A + GH +V ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLL 358
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N+ +PLH A K HV +++LLL GAS +AV GL P+
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/97 (34%), Positives = 54/97 (55%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
A+ G++ L+NG D N + G LH A GH+K+V LL + ++ TT +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
++ LH AA G ++V+ L++YGA+ NA + G P+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/107 (33%), Positives = 52/107 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LL G T LH A G +VV L+ +
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN + +PL+ AA+ H+++VK LL GA++N G P+
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ +G T L++A+ + + V++LL+NG++ NV G+TPL A GH VV L+ +
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 484 --KALVNTTGY----------------QND-----------SPLHDAAKNGHVDIVKLLL 514
K V QND +PLH AA ++++ +LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 515 SYGASRNAVNIFGLRPV 531
+ GAS N G+ P+
Sbjct: 227 NRGASVNFTPQNGITPL 243
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 90.9 bits (224), Expect = 4e-18
Identities = 53/127 (41%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G +P V+ LLQ G+ PNV + TPLH A GH +V + LLQ+KA V
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES-MKSLLLLP 546
N + +PLH AA+ GH ++VKLLL A+ N G P+ E ++++L L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Query: 547 EKNESSS 553
EK S +
Sbjct: 524 EKEASQA 530
Score = 88.2 bits (217), Expect = 3e-17
Identities = 46/107 (42%), Positives = 66/107 (61%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+ + +G +P + L+++G + G+TPLH A ++G++K+V+ LLQH+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN SPLH AA+ GH DIV LLL GAS N V+ G P+
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 80.5 bits (197), Expect = 6e-15
Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 11/210 (5%)
Query: 347 FVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKN--SNMSDEFISLSPGTPPSTLSSSSY 404
++ Q N + +P C ++G T+ K N ++ ++ + G P +++
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA--- 511
Query: 405 RRVMSSPSAMKLLPNMAVKR--NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGW 462
R + + LL A + +G T LH+A+ G + E LL+ + PN G
Sbjct: 512 -REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 463 TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
TPLH A +H +L +V+LLL ++ + +PLH AAK V++ + LL YG S NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 523 VNIFGLRPVDYTDDE---SMKSLLLLPEKN 549
++ G+ P+ E M +LLL + N
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/104 (38%), Positives = 58/104 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIAS +G++ V LL G+ K TPLH A +GH+++ E+LL H A +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
SP+H AA+ H+D V+LLL Y A + + + L P+
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Score = 73.2 bits (178), Expect = 9e-13
Identities = 40/126 (31%), Positives = 67/126 (53%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ +G V LL ++ N+ + +G TPLH GH+ V ++L++H +
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
V+ T +PLH A+ G++ +VK LL + A NA G P+ + ++ L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 547 EKNESS 552
KN +S
Sbjct: 754 LKNGAS 759
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/138 (36%), Positives = 70/138 (50%), Gaps = 9/138 (6%)
Query: 388 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHR---GETLLHIASIKGDIPSV 444
I+L TP + + RV K+L + K N R G T LHIA K + +
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVA------KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 445 EYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKN 504
E LL+ G+ + +G TPLH A GHL +V+ LLQ A N + + ++PLH AA+
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 505 GHVDIVKLLLSYGASRNA 522
GH ++ K LL A NA
Sbjct: 448 GHTEVAKYLLQNKAKVNA 465
Score = 71.6 bits (174), Expect = 3e-12
Identities = 40/96 (41%), Positives = 56/96 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL G+ PN + G+TPLH AC H++V+ELLL+ A ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNI 525
+PLH A+ GH+ IVK LL GAS N N+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/120 (37%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN A K G T LH+A ++ V+ LL G P+ G+TPLH A ++V
Sbjct: 562 PNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LLQ+ N Q +PLH AA+ GH ++V LLLS A+ N N GL P+ E
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Score = 70.1 bits (170), Expect = 7e-12
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN++ N + ET LH+A+ G +YLLQN + N K TPLH A GH +V
Sbjct: 430 PNVS---NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+LLL++ A N +PLH AA+ GHV+ V LL AS+ + G P+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/87 (43%), Positives = 53/87 (60%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ D + LLQN +P+V G+TPLH A ++ +L V +LLL A VN T
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
+PLH A++ G+V +V+LLL GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA 263
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/104 (39%), Positives = 56/104 (53%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ ++ + LL G+ N G TPLH A G++ +V LLL A +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
T +PLH AA+NGHV I ++LL +GA A GL P+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/123 (32%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LHIA++ G V L+ G++ N + G+TPL+ A HL+VV+ LL++ A
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLP 546
N +PL A + GH ++V L++YG ++ V + L DD ++LL
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 547 EKN 549
+ N
Sbjct: 196 DPN 198
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 52/104 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+ + + LLQ G N + G TPLH A GH ++V LLL +A
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH A+ GHV + +L+ +G +A G P+
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/86 (38%), Positives = 51/86 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+AS G+I V++LLQ+ +D N K G++PLH+A GH +V LLL++ A
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLL 513
N +PL A + G++ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 53/102 (51%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH A+ G + E LL +G+ K G +P+H A HL V LLLQ+ A ++
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH AA GH + K+LL GA N+ + G P+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Score = 60.5 bits (145), Expect = 6e-09
Identities = 40/110 (36%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS--DPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ G + +H+A+ + V LLQ + D DH TPLH A + GH +V ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLL 358
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N+ +PLH A K HV +++LLL GAS +AV GL P+
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/97 (34%), Positives = 54/97 (55%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
A+ G++ L+NG D N + G LH A GH+K+V LL + ++ TT +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
++ LH AA G ++V+ L++YGA+ NA + G P+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/107 (33%), Positives = 52/107 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LL G T LH A G +VV L+ +
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A VN + +PL+ AA+ H+++VK LL GA++N G P+
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ +G T L++A+ + + V++LL+NG++ NV G+TPL A GH VV L+ +
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 484 --KALVNTTGY----------------QND-----------SPLHDAAKNGHVDIVKLLL 514
K V QND +PLH AA ++++ +LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 515 SYGASRNAVNIFGLRPV 531
+ GAS N G+ P+
Sbjct: 227 NRGASVNFTPQNGITPL 243
>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 6e-17
Identities = 106/416 (25%), Positives = 160/416 (38%), Gaps = 47/416 (11%)
Query: 170 KKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKT-LAEINQKWNLEAEKEDGE 228
K+ S E + P D +AK+ G KK+ L + ++W + DG+
Sbjct: 1135 KRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKGLHPKKQRHLLHLRERWEQQVSAADGK 1194
Query: 229 FDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIE- 287
+K V+ +QP I PQ + E++ S +E SL ++ +
Sbjct: 1195 ---PGRQSRKEVTQATQPEAI--PQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQG 1249
Query: 288 ------SPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR---LSSPISKRCRT 338
SP KS + K + S P K + + L + + C+
Sbjct: 1250 LPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQA 1309
Query: 339 SIL---------STSGDFV---KQTVPSEN---IPLPECSSPPSCKRKVGGTSGRKNSNM 383
+ L SG + K +P E+ +PL + KV RK
Sbjct: 1310 ASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEP 1369
Query: 384 S---------------DEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRG 428
S D L P + + L SS + + M + + G
Sbjct: 1370 SSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAG 1429
Query: 429 ETLLHIASIKGDIPSVEYLLQNG-SDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
ETLL A+ G V Y L+N D N +D+AG+ LHEAC G L +V LL++ A V
Sbjct: 1430 ETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADV 1489
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N + PLHDA +N H++IV+LLLSYGA G + T E M+ L
Sbjct: 1490 NCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
Length = 1703
Score = 87.0 bits (214), Expect = 6e-17
Identities = 106/416 (25%), Positives = 160/416 (38%), Gaps = 47/416 (11%)
Query: 170 KKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKT-LAEINQKWNLEAEKEDGE 228
K+ S E + P D +AK+ G KK+ L + ++W + DG+
Sbjct: 1117 KRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKGLHPKKQRHLLHLRERWEQQVSAADGK 1176
Query: 229 FDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIE- 287
+K V+ +QP I PQ + E++ S +E SL ++ +
Sbjct: 1177 ---PGRQSRKEVTQATQPEAI--PQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQG 1231
Query: 288 ------SPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR---LSSPISKRCRT 338
SP KS + K + S P K + + L + + C+
Sbjct: 1232 LPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQA 1291
Query: 339 SIL---------STSGDFV---KQTVPSEN---IPLPECSSPPSCKRKVGGTSGRKNSNM 383
+ L SG + K +P E+ +PL + KV RK
Sbjct: 1292 ASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEP 1351
Query: 384 S---------------DEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRG 428
S D L P + + L SS + + M + + G
Sbjct: 1352 SSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAG 1411
Query: 429 ETLLHIASIKGDIPSVEYLLQNG-SDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
ETLL A+ G V Y L+N D N +D+AG+ LHEAC G L +V LL++ A V
Sbjct: 1412 ETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADV 1471
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N + PLHDA +N H++IV+LLLSYGA G + T E M+ L
Sbjct: 1472 NCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1527
>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 6e-17
Identities = 106/416 (25%), Positives = 160/416 (38%), Gaps = 47/416 (11%)
Query: 170 KKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKT-LAEINQKWNLEAEKEDGE 228
K+ S E + P D +AK+ G KK+ L + ++W + DG+
Sbjct: 1135 KRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKGLHPKKQRHLLHLRERWEQQVSAADGK 1194
Query: 229 FDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIE- 287
+K V+ +QP I PQ + E++ S +E SL ++ +
Sbjct: 1195 ---PGRQSRKEVTQATQPEAI--PQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQG 1249
Query: 288 ------SPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR---LSSPISKRCRT 338
SP KS + K + S P K + + L + + C+
Sbjct: 1250 LPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQA 1309
Query: 339 SIL---------STSGDFV---KQTVPSEN---IPLPECSSPPSCKRKVGGTSGRKNSNM 383
+ L SG + K +P E+ +PL + KV RK
Sbjct: 1310 ASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEP 1369
Query: 384 S---------------DEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRG 428
S D L P + + L SS + + M + + G
Sbjct: 1370 SSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAG 1429
Query: 429 ETLLHIASIKGDIPSVEYLLQNG-SDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
ETLL A+ G V Y L+N D N +D+AG+ LHEAC G L +V LL++ A V
Sbjct: 1430 ETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADV 1489
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N + PLHDA +N H++IV+LLLSYGA G + T E M+ L
Sbjct: 1490 NCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
Length = 1755
Score = 86.7 bits (213), Expect = 8e-17
Identities = 57/160 (35%), Positives = 78/160 (48%), Gaps = 1/160 (0%)
Query: 385 DEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSV 444
D L P + + L SS + + M + + GETLL A+ G V
Sbjct: 1420 DRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVV 1479
Query: 445 EYLLQNG-SDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAK 503
Y L+N D N +D+AG+ LHEAC G L +V LL++ A VN + PLHDA +
Sbjct: 1480 LYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVE 1539
Query: 504 NGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
N H++IV+LLLSYGA G + T E M+ L
Sbjct: 1540 NDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1579
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 82.0 bits (201), Expect = 2e-15
Identities = 49/152 (32%), Positives = 79/152 (51%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH++ +G + V+ L+ +D N D+ + L A GH+KVV+LL++H A+V
Sbjct: 979 GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPE 547
+ T Q + L AA+ GH+D+V++LL +GA N + FG + ++ L E
Sbjct: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLE 1098
Query: 548 KNESSSASHCSVMNTGQRRDGPLVLIGSGLSS 579
K +SS + CS PL + S + S
Sbjct: 1099 KYGASSLNGCSPSPVHTMEQKPLQSLSSKVQS 1130
Score = 72.4 bits (176), Expect = 2e-12
Identities = 48/139 (34%), Positives = 64/139 (46%), Gaps = 34/139 (24%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEAC------------------ 469
G T+L IAS +G++ V LL G D N +D AGWTPLH A
Sbjct: 814 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Query: 470 ---------------NHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLL 514
GH V++LL++K+ ++ GY + L AA GH DIV+LL
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 515 SYGASRNAVNIFGLRPVDY 533
S+GA N + G RP Y
Sbjct: 934 SHGADVNCKDADG-RPTLY 951
Score = 70.1 bits (170), Expect = 7e-12
Identities = 33/91 (36%), Positives = 54/91 (59%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G L+I +++ + EY L+NG++ D G T LH +C GH+++V++L+ + A V
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGA 518
N + S L AA GHV +V+LL+ +GA
Sbjct: 1006 NAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/145 (35%), Positives = 69/145 (47%), Gaps = 22/145 (15%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEA-----CNHGHLKVV 477
K ++ G T L A+ G VE+LL +G++ N +D G T L A + GH VV
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
LL+ A V+ +PL AA GHVD+V LLL GA VD+TD+
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD-----------VDHTDNN 780
Query: 538 SMKSLLLLPEKNESSSASHCSVMNT 562
LL ++S H SV+NT
Sbjct: 781 GRTPLL------AAASMGHASVVNT 799
Score = 57.8 bits (138), Expect = 4e-08
Identities = 34/90 (37%), Positives = 45/90 (50%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G TLL A+ G + V L+ G+D ++D G TPL A GH KVV L+ A +
Sbjct: 545 GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYG 517
N T + L AA GH ++V LL G
Sbjct: 605 NHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Score = 57.8 bits (138), Expect = 4e-08
Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 428 GETLLHIASI-----KGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
G T L +A++ KG V L+ G++ + D G TPL A GH+ VV+LLL+
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
A V+ T +PL AA GH +V LL +GA+ ++++ G
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/123 (31%), Positives = 64/123 (52%), Gaps = 3/123 (2%)
Query: 412 SAMKLLPNMAVKRNH---RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEA 468
S + LL + + +H G T L +A+ +G + V+ LL+ G+D + D+ G TPL A
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 469 CNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGL 528
+ GH VV LL A V++ + + L A+ G+V++V+ LL G N + G
Sbjct: 789 ASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW 848
Query: 529 RPV 531
P+
Sbjct: 849 TPL 851
Score = 55.5 bits (132), Expect = 2e-07
Identities = 30/102 (29%), Positives = 54/102 (52%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+R + G L +A+++G VE L +G+D N KD G L+ L + E L+
Sbjct: 908 QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE 967
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVN 524
+ A V + + + LH + GH+++V++L++Y A NA +
Sbjct: 968 NGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Score = 53.1 bits (126), Expect = 9e-07
Identities = 35/94 (37%), Positives = 46/94 (48%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T L +A+ +G V L+ G++ N D GWT L A GH +VV LL V
Sbjct: 578 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV 637
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRN 521
+ + + L AA GH DIV LL +GA N
Sbjct: 638 DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Score = 47.4 bits (111), Expect = 5e-05
Identities = 26/74 (35%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 426 HRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKA 485
++G T L IA+ +G I V+ LL++G+DPN D G T + A +GH ++++LL ++ A
Sbjct: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Query: 486 LVNTTGYQNDSPLH 499
++ + SP+H
Sbjct: 1103 --SSLNGCSPSPVH 1114
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/79 (36%), Positives = 38/79 (48%)
Query: 443 SVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAA 502
S+ LL NG+ N D G T L A G L VV LL+ A + +PL AA
Sbjct: 527 SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586
Query: 503 KNGHVDIVKLLLSYGASRN 521
+ GH +V L+ GA+ N
Sbjct: 587 RQGHTKVVNCLIGCGANIN 605
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/100 (36%), Positives = 46/100 (46%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T L A+ G V LL G + D T L A GH +V LLQH A V
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
N + + L AA GH +IV+ LL +GA N ++ G
Sbjct: 671 NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/94 (29%), Positives = 43/94 (45%)
Query: 434 IASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQ 493
+AS +G V+ LL+N S+ + + + G L A GH +VELL H A VN
Sbjct: 886 LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945
Query: 494 NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
L+ A + + + L GA+ A + G
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEG 979
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 80.1 bits (196), Expect = 7e-15
Identities = 39/103 (37%), Positives = 59/103 (57%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH+A+ + + E L+ G+ + + G+TPLH C++G++K+V LLQH
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS 753
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
A VN +PLH AA+ GH I+ +LL AS N + + G
Sbjct: 754 AKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG 796
Score = 78.2 bits (191), Expect = 3e-14
Identities = 42/100 (42%), Positives = 63/100 (63%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
LHIA+ K D + LLQN ++ +V+ +G+TPLH A ++G++ V LLL A V+ T
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH A+K G+ ++VKLLL GA +A GL P+
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305
Score = 78.2 bits (191), Expect = 3e-14
Identities = 41/98 (41%), Positives = 57/98 (58%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+A+ G + LL ++PN K G+TPLH AC +KV+ELLL+H A +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFG 527
+P+H AA GHV+IV L+ +GAS N N+ G
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Score = 77.8 bits (190), Expect = 4e-14
Identities = 47/128 (36%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 429 ETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVN 488
+T LHI++ G V+ LLQ G+ PN +G+TPLH + GH V LL H A ++
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 489 TTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDD-ESMKSLLLLPE 547
T + +PLH AAK G +++ LLL AS +A GL P+ ++ K LLL +
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Query: 548 KNESSSAS 555
+ S A+
Sbjct: 620 QGASPHAA 627
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/107 (37%), Positives = 55/107 (51%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N RGET LH+A+ G V YL+Q+G+ K TPLH + G +V+ LLQ
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
A N +PLH +A+ GH D+ LL +GAS + G P+
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/121 (38%), Positives = 60/121 (49%), Gaps = 3/121 (2%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G T LH+A+ G + LLQ + P+ +G TPLH A ++ + KV LLL A
Sbjct: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623
Query: 487 VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE---SMKSLL 543
+ +PLH AAK +DI LL YGA NAV G+ V E M SLL
Sbjct: 624 PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Query: 544 L 544
L
Sbjct: 684 L 684
Score = 71.2 bits (173), Expect = 3e-12
Identities = 39/104 (37%), Positives = 55/104 (52%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T +H+A+ G + V L+ +G+ PN + G T LH A G +VV L+Q A V
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ +PLH +A+ G DIV+ LL GAS NA G P+
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
Score = 67.8 bits (164), Expect = 4e-11
Identities = 36/95 (37%), Positives = 54/95 (56%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA K I +E LL++G+ +G TP+H A GH+ +V L+ H A
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
NTT + ++ LH AA++G ++V+ L+ GA A
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494
Score = 66.6 bits (161), Expect = 8e-11
Identities = 41/143 (28%), Positives = 70/143 (48%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G LH+AS +G + V LLQ ++ + G T LH A G +VV++L+ +
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
A VN +PL+ AA+ H+++VK LL GAS++ G P+ + ++
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 545 LPEKNESSSASHCSVMNTGQRRD 567
L +N++ ++ R+D
Sbjct: 191 LLLENDTKGKVRLPALHIAARKD 213
Score = 63.2 bits (152), Expect = 9e-10
Identities = 37/104 (35%), Positives = 55/104 (52%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+++ +G +LL +G+ ++ G+TPLH A +G L+V LLLQ A
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+ G +PLH AA + + LLL GAS +A G P+
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPL 635
Score = 63.2 bits (152), Expect = 9e-10
Identities = 38/110 (34%), Positives = 54/110 (49%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+A+ + LL G+ P+ G+TPLH A + + LL++ A
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
N Q + +H AA+ GHVD+V LLL A+ N N GL P+ E
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE 707
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/114 (34%), Positives = 58/114 (50%), Gaps = 3/114 (2%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
P+ A K G T LHIA+ K + LL+ G+D N G +H A GH+ +V
Sbjct: 624 PHAAAKN---GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
LLL A VN + +PLH AA+ V++ ++L++ GA +A G P+
Sbjct: 681 SLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/110 (33%), Positives = 57/110 (51%)
Query: 422 VKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLL 481
+ + G + LH+A+ + V+ LLQ+ + + T LH A + GH KV ++LL
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 482 QHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
KA N +PLH A K + +++LLL +GAS AV GL P+
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Score = 61.2 bits (147), Expect = 3e-09
Identities = 34/87 (39%), Positives = 49/87 (56%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH+AS +G+ V+ LL G+ + K G TPLH GH +VVE+LL A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSY 516
SPLH A + H++ V+LLL +
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 60.8 bits (146), Expect = 5e-09
Identities = 65/252 (25%), Positives = 114/252 (45%), Gaps = 21/252 (8%)
Query: 272 FGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLS-- 329
+G L EV+ L ++ SPD ++ + TP V +Y K +L L + G H +
Sbjct: 575 YGKL-EVANLLLQKSASPDAAGKSGL-TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 632
Query: 330 SPI---SKRCRTSILSTSGDFVKQT--VPSENIPLPECSSPPSCKRKVGGTSGRKNSNMS 384
+P+ +K+ + I +T ++ V + I ++ V GR N+N++
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR-NANVN 691
Query: 385 DEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVK---RNHRGETLLHIASIKGDI 441
+S G P L++ R + ++L N + G T LH+ G+I
Sbjct: 692 ---LSNKSGLTPLHLAAQEDR-----VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743
Query: 442 PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501
V +LLQ+ + N K G+TPLH+A GH ++ +LLQ+ A N ++ L A
Sbjct: 744 KIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIA 803
Query: 502 AKNGHVDIVKLL 513
+ G++ +V L
Sbjct: 804 RRLGYISVVDTL 815
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/121 (34%), Positives = 56/121 (46%), Gaps = 3/121 (2%)
Query: 414 MKLLPNMAVK---RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACN 470
+KLL + K + G T LH + G VE LL + K G +PLH A
Sbjct: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Query: 471 HGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRP 530
HL V+LLLQH V+ + LH AA GH + K+LL A+ NA + G P
Sbjct: 344 GDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403
Query: 531 V 531
+
Sbjct: 404 L 404
Score = 56.2 bits (134), Expect = 1e-07
Identities = 30/84 (35%), Positives = 50/84 (59%)
Query: 448 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV 507
++NG D N+ + G LH A GH++VV LLQ +A V+ + ++ LH A+ G
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
Query: 508 DIVKLLLSYGASRNAVNIFGLRPV 531
++VK+L++ GA+ NA + G P+
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPL 144
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 4/108 (3%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
++ G T L++A+ + + V++LL NG+ ++ G+TPL A GH +VV LLL++
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
+T G LH AA+ LLL + + + G P+
Sbjct: 196 ----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL 239
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 79.7 bits (195), Expect = 9e-15
Identities = 42/103 (40%), Positives = 60/103 (58%)
Query: 435 ASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQN 494
AS++ D V Y L+N P++ + G T LH+ C ++V+LLL H A VN +
Sbjct: 75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
Query: 495 DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
+PLH AA GH+++VK+L+ YGA AVN G P D +DE
Sbjct: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/113 (33%), Positives = 59/113 (52%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
+ +A + I + ++ G D + D G T LH A +G+L+ ELLL H V+
Sbjct: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLL 544
+ PLH AA G + + +LL+S+GAS +A P+D ++E K LLL
Sbjct: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLL 312
Score = 57.0 bits (136), Expect = 7e-08
Identities = 28/72 (38%), Positives = 42/72 (58%)
Query: 427 RGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKAL 486
+G TLLHIA G + + E LL +G +VKD GW PLH A G +++ ELL+ H A
Sbjct: 228 QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
Query: 487 VNTTGYQNDSPL 498
++ ++ P+
Sbjct: 288 LSARTSMDEMPI 299
Score = 55.5 bits (132), Expect = 2e-07
Identities = 31/107 (28%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHK 484
N G T LH I V+ LL +G++ N KD+ WTPLH A GH+ +V++L+Q+
Sbjct: 98 NEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYG 157
Query: 485 ALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSY-GASRNAVNIFGLRP 530
A + + P +D+++ ++Y G ++ +N + P
Sbjct: 158 ADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAP 204
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 79.3 bits (194), Expect = 1e-14
Identities = 42/103 (40%), Positives = 58/103 (56%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
T LH AS++G + +E LL NG+ + +D T +H AC GHL+VV+LL H A N
Sbjct: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
Query: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD 532
+ D+ LHDA + I+KLLL +GA N+ G P D
Sbjct: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTD 285
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/93 (34%), Positives = 53/93 (56%), Gaps = 1/93 (1%)
Query: 429 ETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVN 488
ET L A+++G + +E L +G + D T LH A GH++++E LL + A V+
Sbjct: 150 ETFLK-AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVD 208
Query: 489 TTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRN 521
+ + +H A + GH+++VKLL S+GA N
Sbjct: 209 FQDRLDCTAMHWACRGGHLEVVKLLQSHGADTN 241
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 77.8 bits (190), Expect = 4e-14
Identities = 40/91 (43%), Positives = 59/91 (64%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+I G + + + LLQ+G++ N++D +TPLH A +GH +V LLL+ A V
Sbjct: 134 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 193
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGA 518
N +G D PLH A+ G ++I KLL+ G+
Sbjct: 194 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 224
Score = 69.3 bits (168), Expect = 1e-11
Identities = 41/104 (39%), Positives = 55/104 (52%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+A K + + LL +G+D + G T LH A GHL+ ++LLQH A V
Sbjct: 101 GFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 160
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH AA GH + +LLL +GA N G RP+
Sbjct: 161 NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPL 204
Score = 60.8 bits (146), Expect = 5e-09
Identities = 41/106 (38%), Positives = 55/106 (51%), Gaps = 4/106 (3%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH--KALV 487
T LHIA+ G LL+ G+D NV G PLH A G L + +LL++ KA V
Sbjct: 169 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLL--SYGASRNAVNIFGLRPV 531
N ++ PLH ++ GH DIVK LL + VNI+G P+
Sbjct: 229 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 4/103 (3%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQ-NGSDPNVKDHA-GWTPLHEACNHGH-LKVVELLL 481
N G+T LH+A G + ++Q +G++ K++ T H AC +G + +V+ LL
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
Query: 482 QHKAL-VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAV 523
+ +N G + LH A +GH+ +V+ LL GA N V
Sbjct: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 424 RNHRGETLLHIASIKGDIPS-VEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
R G +LLH+ I G S + L+ G P+ G+T LH A + +++ LL
Sbjct: 63 RTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRN---AVNIFGLRPVDYTDDESM 539
A + GY + LH A GH++ +LL +GA+ N AV L Y E +
Sbjct: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
Query: 540 KSLLL 544
LLL
Sbjct: 183 TRLLL 187
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/105 (36%), Positives = 54/105 (51%), Gaps = 11/105 (10%)
Query: 423 KRNHRGETLLHIASIKG-DIPSVEYLL-QNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 480
K N ET H A G I V++LL QN + N + G T LH AC HGH+++V+ L
Sbjct: 300 KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359
Query: 481 LQHKALVN--------TTGYQNDSP-LHDAAKNGHVDIVKLLLSY 516
L + A +N ++G +++ L A + GH IV LL Y
Sbjct: 360 LDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHY 404
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 77.8 bits (190), Expect = 4e-14
Identities = 40/91 (43%), Positives = 59/91 (64%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LHIA+I G + + + LLQ+G++ N++D +TPLH A +GH +V LLL+ A V
Sbjct: 235 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 294
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGA 518
N +G D PLH A+ G ++I KLL+ G+
Sbjct: 295 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 325
Score = 69.3 bits (168), Expect = 1e-11
Identities = 41/104 (39%), Positives = 55/104 (52%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G T LH+A K + + LL +G+D + G T LH A GHL+ ++LLQH A V
Sbjct: 202 GFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 261
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 531
N +PLH AA GH + +LLL +GA N G RP+
Sbjct: 262 NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPL 305
Score = 60.8 bits (146), Expect = 5e-09
Identities = 41/106 (38%), Positives = 55/106 (51%), Gaps = 4/106 (3%)
Query: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH--KALV 487
T LHIA+ G LL+ G+D NV G PLH A G L + +LL++ KA V
Sbjct: 270 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLL--SYGASRNAVNIFGLRPV 531
N ++ PLH ++ GH DIVK LL + VNI+G P+
Sbjct: 330 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 4/103 (3%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQ-NGSDPNVKDHA-GWTPLHEACNHGH-LKVVELLL 481
N G+T LH+A G + ++Q +G++ K++ T H AC +G + +V+ LL
Sbjct: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
Query: 482 QHKAL-VNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAV 523
+ +N G + LH A +GH+ +V+ LL GA N V
Sbjct: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 424 RNHRGETLLHIASIKGDIPS-VEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
R G +LLH+ I G S + L+ G P+ G+T LH A + +++ LL
Sbjct: 164 RTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRN---AVNIFGLRPVDYTDDESM 539
A + GY + LH A GH++ +LL +GA+ N AV L Y E +
Sbjct: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
Query: 540 KSLLL 544
LLL
Sbjct: 284 TRLLL 288
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/105 (36%), Positives = 54/105 (51%), Gaps = 11/105 (10%)
Query: 423 KRNHRGETLLHIASIKG-DIPSVEYLL-QNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 480
K N ET H A G I V++LL QN + N + G T LH AC HGH+++V+ L
Sbjct: 401 KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 460
Query: 481 LQHKALVN--------TTGYQNDSP-LHDAAKNGHVDIVKLLLSY 516
L + A +N ++G +++ L A + GH IV LL Y
Sbjct: 461 LDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHY 505
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 77.8 bits (190), Expect = 4e-14
Identities = 48/125 (38%), Positives = 71/125 (56%), Gaps = 2/125 (1%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
RN LH+A +G V+ LL + + PN KD +G TPL AC+ GH ++V LLLQH
Sbjct: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH 832
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDES--MKS 541
A +N + + ++ LH+A HV +V+LLL +GAS +N VD + S M+
Sbjct: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMEL 892
Query: 542 LLLLP 546
L ++P
Sbjct: 893 LQVVP 897
Score = 72.0 bits (175), Expect = 2e-12
Identities = 37/93 (39%), Positives = 51/93 (54%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R+ RG T LH+A++ G ++ L+ G+ N D+ G TPLH AC G+ V LLL +
Sbjct: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSY 516
KA ++PLH A GH D VK L+ Y
Sbjct: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
Score = 68.6 bits (166), Expect = 2e-11
Identities = 36/97 (37%), Positives = 54/97 (55%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV 487
G + LH+A++ G + LL++G++ ++ PLH AC GH +VV+ LL A
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803
Query: 488 NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVN 524
N ++PL A GH ++V LLL +GAS NA N
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840
Score = 56.6 bits (135), Expect = 9e-08
Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 29/158 (18%)
Query: 452 SDPNV-----KDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGH 506
+DP+V +D G TPLH A G +++LL+ A+VN T Y +PLH A + G+
Sbjct: 449 NDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGY 508
Query: 507 VDIVKLLLSYGASRNAVNIFGLRPV----DYTDDESMKSLLLLPEKNESSSASHCSVMNT 562
+ LLL Y AS + G P+ Y ++ +K+L+ C +
Sbjct: 509 QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYY-------DVESCRLDIG 561
Query: 563 GQRRDGPL-------------VLIGSGLSSEQQKMLSE 587
++ D PL L+ +G S+E Q L E
Sbjct: 562 NEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKE 599
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/108 (33%), Positives = 50/108 (46%), Gaps = 1/108 (0%)
Query: 450 NGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDI 509
+G NV G +PLH A HG ++ LLL+H A PLH A + GH +
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
Query: 510 VKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL-LLPEKNESSSASH 556
VK LL A N ++ G P+ Y L+ LL + S +AS+
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 1/102 (0%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
K++ G T L A G V LLQ+G+ N ++ G T LHEA H+ VVELLL
Sbjct: 805 KKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLL 864
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHV-DIVKLLLSYGASRNAV 523
H A V + + + A +N + ++++++ S AS + V
Sbjct: 865 HGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDV 906
Score = 38.1 bits (87), Expect = 0.031
Identities = 22/54 (40%), Positives = 31/54 (57%)
Query: 425 NHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVE 478
N +G+T LHIA+ G +E LLQNG+ +++ TPL A N L V+E
Sbjct: 562 NEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
Score = 35.8 bits (81), Expect = 0.16
Identities = 37/147 (25%), Positives = 65/147 (44%), Gaps = 13/147 (8%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDP---NVKDHAGWTPLHEACNHGHLKVVELL 480
+++ G T LH+A G V+ L+ + ++ + G TPLH A G+ V+E L
Sbjct: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
Query: 481 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK 540
LQ+ A ++PL A + I+ ++ +Y S PV + S+
Sbjct: 585 LQNGASTEIQNRLKETPLKCALNS---KILSVMEAYHLSFERRQKSSEAPVQ-SPQRSVD 640
Query: 541 SLLLLPEKNESSSASHCSVMNTGQRRD 567
S+ ++ SS S S M+ R++
Sbjct: 641 SI------SQESSTSSFSSMSASSRQE 661
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/96 (41%), Positives = 58/96 (60%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R+ G + LH A+ +G + +V+ L+ G++ + +D G TPLH A GH++V LL
Sbjct: 265 RDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGAS 519
A V+ TG+ +PLH AA+ GH V LLLS GAS
Sbjct: 325 GAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/92 (44%), Positives = 50/92 (54%)
Query: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
+R+H G T LH+A ++G P V LLQ G+ D AG T LHEA HGH +V ELLLQ
Sbjct: 69 ERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQ 128
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLL 514
A +PLH AA GH + LL
Sbjct: 129 RGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/99 (37%), Positives = 55/99 (55%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R+ G T L +A+ G +E LL +G+DP ++D G + LH A GHL V+LL+
Sbjct: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNA 522
A V+ +PLH A++ GHV++ LL GA +A
Sbjct: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA 330
Score = 66.2 bits (160), Expect = 1e-10
Identities = 39/96 (40%), Positives = 52/96 (54%)
Query: 438 KGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSP 497
+G V LL+ G+ +DHAG TPLH A GH +V LLLQ A V +
Sbjct: 51 RGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTA 110
Query: 498 LHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDY 533
LH+AA +GH + +LLL GAS A + GL P+ +
Sbjct: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW 146
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/106 (33%), Positives = 54/106 (50%)
Query: 432 LHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTG 491
L +A+ G ++ +LL G+ + +D AG T L A G + +E+LL H A
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 492 YQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDE 537
S LH AA GH+ V+LL++ GA +A + GL P+ + E
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/95 (31%), Positives = 42/95 (44%), Gaps = 4/95 (4%)
Query: 428 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ----H 483
G T LH A+ G E LLQ G+ + G TPLH A GH + LL+
Sbjct: 107 GRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG 166
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGA 518
A + + H AA G + +++LL + GA
Sbjct: 167 PAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA 201
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/88 (34%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 440 DIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLH 499
++ S E L P+V GW L +A G +V LL+ A V + +PLH
Sbjct: 22 ELDSEEALGTRTEGPSVVQ--GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLH 79
Query: 500 DAAKNGHVDIVKLLLSYGASRNAVNIFG 527
A GH +V+LLL GA AV+ G
Sbjct: 80 LAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 75.9 bits (185), Expect = 1e-13
Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGS-DPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
++ G T LH+A+ KG V+YLL NG D N +D GWTP+ A + H+ +V+LLL
Sbjct: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
Query: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542
+ +N + + LH AA +G VDI ++LL+ +AVNI G P+ E+
Sbjct: 895 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 954
Query: 543 LLL 545
++L
Sbjct: 955 VVL 957
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/131 (29%), Positives = 64/131 (48%), Gaps = 13/131 (9%)
Query: 390 LSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQ 449
LS G TL S+ P ++ P L+ ++ +G++ V +L
Sbjct: 711 LSQGPGKETLESALIALDSEKPKKLRFHPKQ-----------LYFSARQGELQKVLLMLV 759
Query: 450 NGSDPNVK-DHAGW-TPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV 507
+G DPN K +H +PLH A GH+ + +L+Q A ++T +PL +AA+N H+
Sbjct: 760 DGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHL 819
Query: 508 DIVKLLLSYGA 518
+ VK L+ GA
Sbjct: 820 EAVKYLIKAGA 830
Score = 55.8 bits (133), Expect = 1e-07
Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 1/100 (1%)
Query: 418 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 477
PN ++ ++ + LH A+ G + L+Q G++ + TPL EA + HL+ V
Sbjct: 764 PNFKMEHQNK-RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAV 822
Query: 478 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYG 517
+ L++ ALV+ + + LH AAK GH ++V+ LLS G
Sbjct: 823 KYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNG 862
Score = 33.9 bits (76), Expect = 0.59
Identities = 23/84 (27%), Positives = 35/84 (41%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R++ LH A+ G + E LL D + + G +PLH A V L L
Sbjct: 902 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 961
Query: 484 KALVNTTGYQNDSPLHDAAKNGHV 507
+ V + ++PL A+ N V
Sbjct: 962 DSDVTLKNKEGETPLQCASLNSQV 985
>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
Length = 1711
Score = 74.7 bits (182), Expect = 3e-13
Identities = 41/113 (36%), Positives = 62/113 (54%), Gaps = 2/113 (1%)
Query: 433 HIASIKGDIPSVE-YLLQNGS-DPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTT 490
H+A++ + V Y LQ S D N +D+AG+T LHEAC+ G ++ +LL+H A VN +
Sbjct: 1426 HMATVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCS 1485
Query: 491 GYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
P+HDA N +++ + LLLSYGA G + ++MK L
Sbjct: 1486 AQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFL 1538
Score = 38.5 bits (88), Expect = 0.024
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
R++ G T LH A +G + LL++G++ N G P+H+A + +L+ + LLL +
Sbjct: 1452 RDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSY 1511
Query: 484 KALVNTTGYQNDSPLHDAAKNGHVDIVKLLLS 515
A Y + A K D +K LS
Sbjct: 1512 GADPTLATYSGQT----AMKLASSDTMKRFLS 1539
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,748,296
Number of Sequences: 37866
Number of extensions: 1575069
Number of successful extensions: 8908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 378
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 6152
Number of HSP's gapped (non-prelim): 2178
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.