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Search of human proteins with 157266264
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266264 pleckstrin homology-like domain, family B, member
3 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266264 pleckstrin homology-like domain, family B, member 3... 1278 0.0
gi|221219026 pleckstrin homology-like domain, family B, member 1... 250 3e-66
gi|221219024 pleckstrin homology-like domain, family B, member 1... 205 9e-53
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 205 9e-53
gi|197313732 pleckstrin homology-like domain, family B, member 2... 201 2e-51
gi|197313730 pleckstrin homology-like domain, family B, member 2... 201 2e-51
gi|197313728 pleckstrin homology-like domain, family B, member 2... 201 2e-51
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 201 2e-51
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 77 5e-14
gi|148746195 trichohyalin [Homo sapiens] 76 1e-13
gi|203096856 kinesin family member 7 [Homo sapiens] 74 5e-13
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 73 7e-13
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 73 7e-13
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 72 2e-12
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 72 2e-12
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 72 2e-12
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 72 2e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 72 2e-12
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 71 3e-12
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 70 8e-12
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 70 8e-12
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 69 1e-11
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 69 2e-11
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 68 3e-11
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 68 3e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 67 7e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 67 7e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 67 7e-11
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 67 7e-11
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 67 7e-11
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 1278 bits (3307), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVG 60
MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVG
Sbjct: 1 MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVG 60
Query: 61 EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVK 120
EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVK
Sbjct: 61 EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVK 120
Query: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
Query: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
Query: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAE 300
LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAE
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAE 300
Query: 301 SRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQ 360
SRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQ
Sbjct: 301 SRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQ 360
Query: 361 DAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLE 420
DAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLE
Sbjct: 361 DAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLE 420
Query: 421 ASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTR 480
ASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTR
Sbjct: 421 ASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTR 480
Query: 481 RGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLV 540
RGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLV
Sbjct: 481 RGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLV 540
Query: 541 KMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNP 600
KMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNP
Sbjct: 541 KMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNP 600
Query: 601 RLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP 640
RLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP
Sbjct: 601 RLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP 640
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 250 bits (638), Expect = 3e-66
Identities = 215/686 (31%), Positives = 304/686 (44%), Gaps = 154/686 (22%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALT 110
E+ EE E SSTES++ E P + +G L+ ++ + L
Sbjct: 680 ERSDEENLKEECSSTESTQQEHEDAPSTKL--------------QGEVLALEEERAQVLG 725
Query: 111 RVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASE- 169
V ++ RVKEL++Q +E E E+E ALL+GE ER ++E++ + +L E+ A E
Sbjct: 726 HVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALET 785
Query: 170 --------------------------QRGRQQREQEQRRLSQE---RDRLEGLRQRLRKA 200
Q R+ R +E+R L+ + R + E LR ++
Sbjct: 786 GIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRK 845
Query: 201 Q---------GQLDSQPEDQRERL-------LQGVQEMREQLDVAQRAYEDLE------- 237
+ GQ+ +Q + ERL LQ +Q+ +E+L V +R Y L
Sbjct: 846 ERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPK 905
Query: 238 ----FQQLERESRQEE------EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLE 287
+++ R E R P P Q S+A R + +
Sbjct: 906 TTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQ 965
Query: 288 EQLKSLGEQMAAESRGLSRKKEEALQ-----ALSQERSRLLELNCLQGTPGGDFSEPNPA 342
SL +AA + + K++ ALQ + ++R RL EL
Sbjct: 966 NGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELK---------------- 1009
Query: 343 LTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLPRKRGE 400
QK + DA+ +A P F +H S+ + R+RGE
Sbjct: 1010 -------QKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL------PAGRERGE 1056
Query: 401 RGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMER 460
G LS ++S+E S G+S P ++ G G I ME+
Sbjct: 1057 EGEHAYDT--LSLESSDSMETSI--STGGNSACSP--DNMSSASGLDMGKIE----EMEK 1106
Query: 461 LLQQAMAERERLLKAREG------------------TRRGTEGSSGPAVPAI-------- 494
+L++A AE+ RL+++RE R + S +
Sbjct: 1107 MLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMRE 1166
Query: 495 -----TAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTW 549
P T P DL+ H+E GH + C HV +S CRG LVKMGG+IK+W
Sbjct: 1167 KQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSW 1226
Query: 550 RKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTY 609
+KRWF FDR R L+YY DK ETKLKGVIYFQAIEEVYYDHLR A KSPNP LTFCVKT+
Sbjct: 1227 KKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTH 1286
Query: 610 ERLFYMVAPSPEAMRIWMDVIVTAAD 635
+RL+YMVAPS EAMRIWMDVIVT A+
Sbjct: 1287 DRLYYMVAPSAEAMRIWMDVIVTGAE 1312
Score = 37.4 bits (85), Expect = 0.043
Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 16/139 (11%)
Query: 49 GAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEA 108
G E+ E E + S ESS + +A P + SS G+
Sbjct: 1051 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD------------- 1097
Query: 109 LTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAAS 168
+ ++ ME+ +KE ++ L E E+ L R L ER RR E+ R L + A
Sbjct: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEER---RRREQVERRLQSESARR 1154
Query: 169 EQRGRQQREQEQRRLSQER 187
+Q ++ + +++ SQ R
Sbjct: 1155 QQLVEKEVKMREKQFSQAR 1173
Score = 37.0 bits (84), Expect = 0.056
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 28/182 (15%)
Query: 170 QRGRQQREQEQRRLSQERDRLEGL--------RQRLRKAQGQLDSQPEDQRERLLQGVQE 221
+R RQ+R +EQ ER RLE + R G+L S E L G +
Sbjct: 594 RRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP 653
Query: 222 MR----------EQLDVA-QRAYEDLEFQQLE--RESRQEEEDRDSPGPQVPDPKVQELQ 268
R E+ VA QR +E +E E +E E P K+Q
Sbjct: 654 SRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEV 713
Query: 269 ASMAQHRRGALQH------RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRL 322
++ + R L H R++ LE+QL+ + E R L + + EA +AL Q+ +
Sbjct: 714 LALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEME-RALLQGEREAERALLQKEQKA 772
Query: 323 LE 324
++
Sbjct: 773 VD 774
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 205 bits (522), Expect = 9e-53
Identities = 214/734 (29%), Positives = 299/734 (40%), Gaps = 145/734 (19%)
Query: 6 SPEEGTPPPLVPECD-VEVQPQGHPEESREQEASEVLAEPSSR----GGAEQQAEEEEVG 60
S E L EC E Q H + + EVLA R G EQ +
Sbjct: 678 SMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKEL 737
Query: 61 EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ--------GQQLEALTRV 112
E ES+R+A + + +E + A +LQ G Q E
Sbjct: 738 EQQLQESAREAEMERALLQGEREAERALLQKE--QKAVDQLQEKLVALETGIQKERDKEA 795
Query: 113 ALMEQRVK-----ELQRQRKELRIEMEVEVA---LLRGELAGERVAARREEE------QL 158
+E K E Q+ +E R+E E E+A LLR + R A+R+E Q
Sbjct: 796 EALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQA 855
Query: 159 RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQG-----QLDSQPEDQRE 213
++ Q +R + + + L +E+++L L +R G + S ++ +
Sbjct: 856 GQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEK 915
Query: 214 RLLQGV------QEMREQLDVAQ--------------RAYEDLEFQQLERESRQEE---E 250
LL V QE+ L +A L+ + + +
Sbjct: 916 LLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPR 975
Query: 251 DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEE 310
R P P Q S+A R + + SL +AA + + K++
Sbjct: 976 TRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQL 1035
Query: 311 ALQ-----ALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQDAVAH 365
ALQ + ++R RL EL QK + DA+
Sbjct: 1036 ALQQKGQQVIEEQRRRLAELK-----------------------QKAAAEAQCQWDALHG 1072
Query: 366 SAATPTSSCLFS--VHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASA 423
+A P F +H S+ + R+RGE G LS ++S+E S
Sbjct: 1073 AAPFPAGPSGFPPLMHHSILHHL------PAGRERGEEGEHAYDT--LSLESSDSMETSI 1124
Query: 424 LPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREG----- 478
G+S P ++ G G I ME++L++A AE+ RL+++RE
Sbjct: 1125 --STGGNSACSP--DNMSSASGLDMGKIE----EMEKMLKEAHAEKNRLMESREREMELR 1176
Query: 479 -------------TRRGTEGSSGPAVPAI-------------TAPPTPPHPPGPRILDLR 512
R + S + P T P DL+
Sbjct: 1177 RQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLK 1236
Query: 513 QHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEET 572
H+E GH + C HV +S CRG LVKMGG+IK+W+KRWF FDR R L+YY DK ET
Sbjct: 1237 THIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHET 1296
Query: 573 KLKGVIYFQAIEEVYYDHLRCAFK-----------SPNPRLTFCVKTYERLFYMVAPSPE 621
KLKGVIYFQAIEEVYYDHLR A K SPNP LTFCVKT++RL+YMVAPS E
Sbjct: 1297 KLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAE 1356
Query: 622 AMRIWMDVIVTAAD 635
AMRIWMDVIVT A+
Sbjct: 1357 AMRIWMDVIVTGAE 1370
Score = 45.4 bits (106), Expect = 2e-04
Identities = 69/292 (23%), Positives = 120/292 (41%), Gaps = 46/292 (15%)
Query: 114 LMEQRVKELQRQRKELRIEMEVEVALL-----RGELA--GERVAA-----RREEEQL--- 158
L EQ ++ L+RQR E + + E + GEL GE AA RR L
Sbjct: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
Query: 159 --RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLR-----KAQGQLDSQPEDQ 211
R E A+++ ++ L +E E +Q K QG++ + E++
Sbjct: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLAL-EEE 719
Query: 212 RERLLQGVQEMREQL-DVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQAS 270
R ++L V++++ ++ ++ Q+ E ++ER Q E + + Q V +LQ
Sbjct: 720 RAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEK 779
Query: 271 MAQHRRGALQHR---IRVLEEQLKSLG----EQMAAESR----------GLSRKKEEALQ 313
+ G + R LE + K +Q+ ESR GL R K E L+
Sbjct: 780 LVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLR 839
Query: 314 ALSQERSRLLELNCLQGTPGGDFSEPNPALTK-----LLFTQKTDRQLLVLQ 360
++++ + RL L+ G + + L + L QK +L VL+
Sbjct: 840 SIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Score = 37.0 bits (84), Expect = 0.056
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 28/182 (15%)
Query: 170 QRGRQQREQEQRRLSQERDRLEGL--------RQRLRKAQGQLDSQPEDQRERLLQGVQE 221
+R RQ+R +EQ ER RLE + R G+L S E L G +
Sbjct: 594 RRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP 653
Query: 222 MR----------EQLDVA-QRAYEDLEFQQLE--RESRQEEEDRDSPGPQVPDPKVQELQ 268
R E+ VA QR +E +E E +E E P K+Q
Sbjct: 654 SRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEV 713
Query: 269 ASMAQHRRGALQH------RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRL 322
++ + R L H R++ LE+QL+ + E R L + + EA +AL Q+ +
Sbjct: 714 LALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEME-RALLQGEREAERALLQKEQKA 772
Query: 323 LE 324
++
Sbjct: 773 VD 774
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 205 bits (522), Expect = 9e-53
Identities = 214/734 (29%), Positives = 299/734 (40%), Gaps = 145/734 (19%)
Query: 6 SPEEGTPPPLVPECD-VEVQPQGHPEESREQEASEVLAEPSSR----GGAEQQAEEEEVG 60
S E L EC E Q H + + EVLA R G EQ +
Sbjct: 678 SMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKEL 737
Query: 61 EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ--------GQQLEALTRV 112
E ES+R+A + + +E + A +LQ G Q E
Sbjct: 738 EQQLQESAREAEMERALLQGEREAERALLQKE--QKAVDQLQEKLVALETGIQKERDKEA 795
Query: 113 ALMEQRVK-----ELQRQRKELRIEMEVEVA---LLRGELAGERVAARREEE------QL 158
+E K E Q+ +E R+E E E+A LLR + R A+R+E Q
Sbjct: 796 EALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQA 855
Query: 159 RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQG-----QLDSQPEDQRE 213
++ Q +R + + + L +E+++L L +R G + S ++ +
Sbjct: 856 GQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEK 915
Query: 214 RLLQGV------QEMREQLDVAQ--------------RAYEDLEFQQLERESRQEE---E 250
LL V QE+ L +A L+ + + +
Sbjct: 916 LLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPR 975
Query: 251 DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEE 310
R P P Q S+A R + + SL +AA + + K++
Sbjct: 976 TRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQL 1035
Query: 311 ALQ-----ALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQDAVAH 365
ALQ + ++R RL EL QK + DA+
Sbjct: 1036 ALQQKGQQVIEEQRRRLAELK-----------------------QKAAAEAQCQWDALHG 1072
Query: 366 SAATPTSSCLFS--VHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASA 423
+A P F +H S+ + R+RGE G LS ++S+E S
Sbjct: 1073 AAPFPAGPSGFPPLMHHSILHHL------PAGRERGEEGEHAYDT--LSLESSDSMETSI 1124
Query: 424 LPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREG----- 478
G+S P ++ G G I ME++L++A AE+ RL+++RE
Sbjct: 1125 --STGGNSACSP--DNMSSASGLDMGKIE----EMEKMLKEAHAEKNRLMESREREMELR 1176
Query: 479 -------------TRRGTEGSSGPAVPAI-------------TAPPTPPHPPGPRILDLR 512
R + S + P T P DL+
Sbjct: 1177 RQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLK 1236
Query: 513 QHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEET 572
H+E GH + C HV +S CRG LVKMGG+IK+W+KRWF FDR R L+YY DK ET
Sbjct: 1237 THIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHET 1296
Query: 573 KLKGVIYFQAIEEVYYDHLRCAFK-----------SPNPRLTFCVKTYERLFYMVAPSPE 621
KLKGVIYFQAIEEVYYDHLR A K SPNP LTFCVKT++RL+YMVAPS E
Sbjct: 1297 KLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAE 1356
Query: 622 AMRIWMDVIVTAAD 635
AMRIWMDVIVT A+
Sbjct: 1357 AMRIWMDVIVTGAE 1370
Score = 45.4 bits (106), Expect = 2e-04
Identities = 69/292 (23%), Positives = 120/292 (41%), Gaps = 46/292 (15%)
Query: 114 LMEQRVKELQRQRKELRIEMEVEVALL-----RGELA--GERVAA-----RREEEQL--- 158
L EQ ++ L+RQR E + + E + GEL GE AA RR L
Sbjct: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
Query: 159 --RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLR-----KAQGQLDSQPEDQ 211
R E A+++ ++ L +E E +Q K QG++ + E++
Sbjct: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLAL-EEE 719
Query: 212 RERLLQGVQEMREQL-DVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQAS 270
R ++L V++++ ++ ++ Q+ E ++ER Q E + + Q V +LQ
Sbjct: 720 RAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEK 779
Query: 271 MAQHRRGALQHR---IRVLEEQLKSLG----EQMAAESR----------GLSRKKEEALQ 313
+ G + R LE + K +Q+ ESR GL R K E L+
Sbjct: 780 LVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLR 839
Query: 314 ALSQERSRLLELNCLQGTPGGDFSEPNPALTK-----LLFTQKTDRQLLVLQ 360
++++ + RL L+ G + + L + L QK +L VL+
Sbjct: 840 SIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Score = 37.0 bits (84), Expect = 0.056
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 28/182 (15%)
Query: 170 QRGRQQREQEQRRLSQERDRLEGL--------RQRLRKAQGQLDSQPEDQRERLLQGVQE 221
+R RQ+R +EQ ER RLE + R G+L S E L G +
Sbjct: 594 RRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP 653
Query: 222 MR----------EQLDVA-QRAYEDLEFQQLE--RESRQEEEDRDSPGPQVPDPKVQELQ 268
R E+ VA QR +E +E E +E E P K+Q
Sbjct: 654 SRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEV 713
Query: 269 ASMAQHRRGALQH------RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRL 322
++ + R L H R++ LE+QL+ + E R L + + EA +AL Q+ +
Sbjct: 714 LALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEME-RALLQGEREAERALLQKEQKA 772
Query: 323 LE 324
++
Sbjct: 773 VD 774
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 201 bits (510), Expect = 2e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 455 IAHMERLLQQAMAERERLLKARE----GTRRGTEGSSG---------------------- 488
I MERLL+QA AE+ RLL++RE +R E
Sbjct: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1094
Query: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 1095 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1154
Query: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 1155 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1214
Query: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 1215 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1246
Score = 114 bits (284), Expect = 4e-25
Identities = 110/418 (26%), Positives = 189/418 (45%), Gaps = 66/418 (15%)
Query: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
Query: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
++ Q E E+++E ALL GE E +E+E L L + A E+ ++ +E+
Sbjct: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEK 669
Query: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
+L ER++LE L++ + + QLD+ PE RE+L Q ++ + LDV + +EDLEFQQ
Sbjct: 670 VKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQ 729
Query: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 730 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
E ++K + L +E+ L L + L G G + +EP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 901 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 940
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 201 bits (510), Expect = 2e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 455 IAHMERLLQQAMAERERLLKARE----GTRRGTEGSSG---------------------- 488
I MERLL+QA AE+ RLL++RE +R E
Sbjct: 1035 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1094
Query: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 1095 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1154
Query: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 1155 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1214
Query: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 1215 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1246
Score = 114 bits (284), Expect = 4e-25
Identities = 110/418 (26%), Positives = 189/418 (45%), Gaps = 66/418 (15%)
Query: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
Query: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
++ Q E E+++E ALL GE E +E+E L L + A E+ ++ +E+
Sbjct: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEK 669
Query: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
+L ER++LE L++ + + QLD+ PE RE+L Q ++ + LDV + +EDLEFQQ
Sbjct: 670 VKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQ 729
Query: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 730 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
E ++K + L +E+ L L + L G G + +EP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 901 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 940
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 201 bits (510), Expect = 2e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 455 IAHMERLLQQAMAERERLLKARE----GTRRGTEGSSG---------------------- 488
I MERLL+QA AE+ RLL++RE +R E
Sbjct: 1019 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1078
Query: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 1079 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1138
Query: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 1139 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1198
Query: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 1199 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1230
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 109/418 (26%)
Query: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 577 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 636
Query: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
++ Q E E+++E ALL GE E +E+E L L
Sbjct: 637 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL------------------N 678
Query: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
R++++ + G ++ + A + LDV + +EDLEFQQ
Sbjct: 679 RKIAELEKNIVG--EKTKDA-----------------------DLLDVESKHFEDLEFQQ 713
Query: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 714 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 764
Query: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
E ++K + L +E+ L L + L G G + +EP
Sbjct: 765 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 824
Query: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 825 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 884
Query: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 885 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 924
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 201 bits (510), Expect = 2e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 455 IAHMERLLQQAMAERERLLKARE----GTRRGTEGSSG---------------------- 488
I MERLL+QA AE+ RLL++RE +R E
Sbjct: 992 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1051
Query: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 1052 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1111
Query: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 1112 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1171
Query: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 1172 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1203
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 109/418 (26%)
Query: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
Query: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
++ Q E E+++E ALL GE E +E+E L L
Sbjct: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL------------------N 651
Query: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
R++++ + G ++ + A + LDV + +EDLEFQQ
Sbjct: 652 RKIAELEKNIVG--EKTKDA-----------------------DLLDVESKHFEDLEFQQ 686
Query: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 687 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
Query: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
E ++K + L +E+ L L + L G G + +EP
Sbjct: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797
Query: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857
Query: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 858 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 897
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 77.0 bits (188), Expect = 5e-14
Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 37/271 (13%)
Query: 80 MAATPPASTSSREGVRGAARRLQ------GQQLEALTR----VALMEQRVKELQRQRKEL 129
+A PPA S E ++ L+ G+QL+A ++L+ +R +E R+++E
Sbjct: 148 LAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEER 207
Query: 130 RIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQRE---QEQRRLSQE 186
E E + L + R +EE+LRE E+ E+R R+ E +++ RL ++
Sbjct: 208 LREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQ 267
Query: 187 RDRLEGLRQRLRKAQGQLDSQPE---DQRERLLQGVQEMREQLDVAQRAYEDLEFQQLER 243
+RL +RL + + +L Q E +Q ERL + + +REQ E+ +Q ER
Sbjct: 268 EERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQ--------EERLCEQEER 319
Query: 244 ESRQEE---EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRI----RVLEEQLKSLGEQ 296
QEE E PG + ++E++ + Q RR Q R+ R+LEE ++ L EQ
Sbjct: 320 LREQEERLCEQEKLPG---QERLLEEVEKLLEQERRQEEQERLLERERLLEE-VEELLEQ 375
Query: 297 MAAESRGLSRKKEEALQALS--QERSRLLEL 325
+ ++E LQ L +E R+LEL
Sbjct: 376 ERLRQQDERLWQQETLQELERLRELERMLEL 406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/230 (24%), Positives = 91/230 (39%), Gaps = 61/230 (26%)
Query: 19 CDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPI 78
C+ E + + E REQE E R E+ E+EE
Sbjct: 223 CEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEE-------------------- 262
Query: 79 AMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVA 138
E +R RL Q+ R+ E+R++E + + E
Sbjct: 263 -------RLCEQEERLREQEERLHEQE----ERLCEQEERLREQEERLCE---------- 301
Query: 139 LLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQ--EQRRLSQERDRLEGLRQR 196
+EE+LRE E+ E+R R+Q E+ EQ +L + LE + +
Sbjct: 302 ---------------QEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKL 346
Query: 197 LRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ---RAYEDLEFQQLER 243
L + + Q + + +RERLL+ V+E+ EQ + Q R ++ Q+LER
Sbjct: 347 LEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELER 396
Score = 30.8 bits (68), Expect = 4.0
Identities = 39/150 (26%), Positives = 61/150 (40%), Gaps = 15/150 (10%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E R +E E L E G E+ EE E + E ++ E
Sbjct: 316 QEERLREQEERLCEQEKLPGQERLLEEVE--KLLEQERRQEEQERLLERERLLEEVEELL 373
Query: 90 SREGVRGAARRL-QGQQLEALTRVALMEQRVK----ELQRQRKELRIEMEVEVALLRGEL 144
+E +R RL Q + L+ L R+ +E+ ++ L QR E R E EL
Sbjct: 374 EQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFE--------EL 425
Query: 145 AGERVAARREEEQLRELLEQQAASEQRGRQ 174
E + + E+Q++EL + A E RG +
Sbjct: 426 NNENKSTLQLEQQVKELKKSGGAEEPRGSE 455
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 75.9 bits (185), Expect = 1e-13
Identities = 81/311 (26%), Positives = 141/311 (45%), Gaps = 12/311 (3%)
Query: 18 ECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPP 77
E + E Q H +E REQ E E++ E E E + RD E
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ-ERRKQQLKRDQEEERRE 486
Query: 78 IAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEV-- 135
+ +E RR Q ++ E + E+R+++ R ++LR E E
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Query: 136 EVALLRGE---LAGERVAAR--REEEQLRELLEQQAASEQRGRQQREQEQRRLSQ-ERDR 189
E L R E L ER R RE+E+ R+ L ++ ++ R +REQE+R + +R+
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 190 LEGLRQRLRKAQGQLDSQPEDQR-ERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE 248
+E L Q R+ Q +PE++R ++LL+ ++ + +R ++ Q+L+RE +E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 249 EEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKK 308
++ + + QEL + R ++ RI + QL+S E A +S+ SR +
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES--EADARQSKVYSRPR 724
Query: 309 EEALQALSQER 319
++ Q QE+
Sbjct: 725 KQEGQRRRQEQ 735
Score = 71.6 bits (174), Expect = 2e-12
Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 35/314 (11%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEE---VGEGSSTESSRDAPEATPPIAMAATPPA 86
EE R + SE+ + R +QQ EE+ + + E S + ++A PP
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR-----LSARPPL 790
Query: 87 STSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG 146
+R R+ + Q+ L EQR ++ + + KEL+ +E E L R E A
Sbjct: 791 REQRERQLRAEERQQREQRF--LPEEEEKEQRRRQRREREKELQF-LEEEEQLQRRERAQ 847
Query: 147 ERVAARREEEQLRELLEQQAASEQRGRQ----QREQEQRRLSQERDRLEGLRQRLRKAQG 202
+ + EE+ L+E E++ + EQR Q Q E+E++R L+++LRK Q
Sbjct: 848 Q---LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904
Query: 203 QLDSQPED-QRERLLQGVQEMREQLDVAQRAYEDL--EFQQLERESRQEEEDRDSPGPQV 259
L + E+ QRE + + R++ + R E L E +QL RE R++ ++
Sbjct: 905 LLQEEEEELQRE---EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 260 PDPKVQELQASM-----AQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQ- 313
D K+Q+ + + + RR + + R EE+L+ EQ+ E R R++E Q
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYRE-EEELQQEEEQLLREEREKRRRQEWERQY 1020
Query: 314 ----ALSQERSRLL 323
L QE +LL
Sbjct: 1021 RKKDELQQEEEQLL 1034
Score = 68.9 bits (167), Expect = 1e-11
Identities = 83/318 (26%), Positives = 134/318 (42%), Gaps = 39/318 (12%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSS 90
E R+++ E EP R ++Q +E E+ EG ++ E
Sbjct: 123 EPRDRQLEE---EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD--RQRRDEELWRQR 177
Query: 91 REGVRGAARRLQGQQL--------------EALTRVALMEQRVK---ELQRQRKEL--RI 131
+E RR + +QL E L R L+E R K E Q+QR+E R+
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 132 EMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQ-REQEQRRLSQERDRL 190
E E E R+EEE+L+E Q+ Q +Q R+ E++ L +ER
Sbjct: 238 FQEEE----EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 191 EGLRQRLRKAQGQLDSQPEDQRERLLQG--VQEMREQLDVAQ-----RAYEDLEFQQLER 243
E +QRLR+ Q Q E++RE+ + QE REQ + + R E+ QQL R
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 244 ESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAES-- 301
E +E ++ Q + + Q+L+ R L+ ++ EQ +Q+ E
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 302 -RGLSRKKEEALQALSQE 318
R ++E+ L+ +E
Sbjct: 414 RREQQLRREQQLRREQEE 431
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/308 (24%), Positives = 133/308 (43%), Gaps = 23/308 (7%)
Query: 22 EVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEE-EVGEGSSTESSRDAPEATPPIAM 80
E + + H +E R+Q+ E + + EE E E + R+ E
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVA-- 138
R RR Q ++ E L L + K L+++R+E R++ E E
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQL----LKREEEKRLEQERREQRLKREQEERRD 576
Query: 139 --LLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQR 196
L R E ++ R +EE+L + L+++ ++REQ +R E +R RQ+
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER----RQQ 632
Query: 197 LRKAQGQLDSQPE----DQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDR 252
L K++ Q + + + +Q+ER Q ++ E+ + QR + E ++ E+E +EE+++
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 253 DSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEAL 312
+ PK Q S A R+ + R R K G++ E R++E L
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPR------KQEGQRRRQEQEEKRRRRESEL 746
Query: 313 QALSQERS 320
Q +ER+
Sbjct: 747 QWQEEERA 754
Score = 68.2 bits (165), Expect = 2e-11
Identities = 73/304 (24%), Positives = 143/304 (47%), Gaps = 25/304 (8%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
EE R++ + A+P+ + EQ +E+++ + E R+ E
Sbjct: 879 EEERKRRRHTLYAKPALQ---EQLRKEQQLLQEEEEELQREEREKR-----------RRQ 924
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQ-RKELRIEMEVEVALLRGELAGER 148
+E +LQ Q+ E L R ++R +E +RQ RK+ +++ + E +L GE
Sbjct: 925 EQERQYREEEQLQ-QEEEQLLREEREKRRRQERERQYRKDKKLQQKEE------QLLGEE 977
Query: 149 VAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
RR +E+ ++ E++ ++ + RE+ ++R QE +R + L++ + QL +
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL-LRE 1036
Query: 209 EDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQ 268
E ++ RL + ++ RE+ ++ Q+ E L ++ E RQE E + ++ + Q L+
Sbjct: 1037 EREKRRLQERERQYREEEEL-QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 269 ASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCL 328
+ RR + + R EE+L+ EQ+ E R R++E Q +E + E L
Sbjct: 1096 EEPEKRRRQERERQCRE-EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 329 QGTP 332
+ P
Sbjct: 1155 REEP 1158
Score = 67.4 bits (163), Expect = 4e-11
Identities = 65/245 (26%), Positives = 122/245 (49%), Gaps = 21/245 (8%)
Query: 88 TSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE 147
T E R + + Q+ E R +E+ + Q++R+E ++ E E E +
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE------ERREQ 517
Query: 148 RVAARREEEQLRELL--EQQAASEQRGRQQ---REQEQRRLSQERDRLEGLRQRLRKAQG 202
R+ + EEE+L++ L EQQ EQ R++ + +E++RL QER R + L++ + +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER-REQRLKREQEERRD 576
Query: 203 QLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEF-----QQLERESRQEEEDRDSPGP 257
QL + E++R++ L+ QE R + + + E LE Q+L+RE +EE +
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 258 QVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+ + + Q+ Q RR + R++ EE+ + L +++ E R++E A + Q
Sbjct: 637 EEQEERRQQQLRREQQERR---EQRLK-REEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 318 ERSRL 322
R R+
Sbjct: 693 ARERI 697
Score = 64.7 bits (156), Expect = 3e-10
Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 11/210 (5%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREE--EQLRELLEQQAASEQRGR 173
EQ ++ + +RK L E ++ + + E RR+E +Q R+ +++ E++ R
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564
Query: 174 QQREQEQRRLSQERDRLEGL-RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRA 232
Q+RE EQ+ QERDR L Q++R+ + + ++Q+ R +G Q++R++ D R
Sbjct: 1565 QERE-EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 233 YEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKS 292
E L ++ E++ ++E DR + P + QE + + R + EEQL
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFL-EEEPQLRRQEREQQLRHDRDRKFRE-----EEQLLQ 1677
Query: 293 LGEQMAAESRGLSRK-KEEALQALSQERSR 321
GE+ + RK +EE Q QER R
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Score = 64.3 bits (155), Expect = 3e-10
Identities = 64/214 (29%), Positives = 104/214 (48%), Gaps = 14/214 (6%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQL------RELL--EQQAA 167
EQ+V+ +R+RK L E ++ R E++ REE+QL R+ L EQQ
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 168 SEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLD 227
++R R+ REQE R ER LE Q+L + Q Q E+Q+ R + Q+ R+ D
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEE-EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 228 VAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLE 287
R E L ++ E++ ++E DR ++ + KV+ Q + Q R + +
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKF---RLEEQKVRR-QEQERKFMEDEQQLRRQEGQ 1610
Query: 288 EQLKSLGEQMAAESRGLSRKKEEALQALSQERSR 321
+QL+ ++ E L +++EE Q QER R
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQ-QLHRQERDR 1643
Score = 63.5 bits (153), Expect = 6e-10
Identities = 63/230 (27%), Positives = 111/230 (48%), Gaps = 9/230 (3%)
Query: 92 EGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAA 151
E +R Q + E + L EQ+V+ +++RK + E ++ + +L ER
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 152 RREEEQ-LRELLEQQAASEQRGRQQREQEQRRLSQERD-RLEGLRQRLRKAQGQLDSQPE 209
RE+EQ L+E EQQ ++R R+ E+E + QER+ +L R R + + QL + E
Sbjct: 1621 FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 210 DQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQA 269
+Q+ R + ++ RE+ +R + +F Q E++ R++E +R + + ++ Q
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
+ R L+ EEQL+ E+ + RK E Q L QER
Sbjct: 1741 RRQERYRKILE------EEQLRPEREEQQLRRQERDRKFREEEQ-LRQER 1783
Score = 62.8 bits (151), Expect = 1e-09
Identities = 83/306 (27%), Positives = 136/306 (44%), Gaps = 24/306 (7%)
Query: 26 QGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPP 85
Q E+ R+ E E+ E +Q+ E+ E R+ E
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER-----REQQE 326
Query: 86 ASTSSREGVRGAARRLQGQQLEA-LTRVALMEQRVKELQRQRKELRIEMEVE-VALLRGE 143
E RR Q ++ E L R E+R ++L+R+++E R E ++ LR E
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 144 LAGERVAARREEEQLRELLEQQAASEQ---RGRQQREQEQRRLSQERDRLEGLRQRLRKA 200
R R E+QLR EQQ EQ R +Q R ++Q R QE +R E ++ R+
Sbjct: 387 QQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 201 QGQLDSQPEDQRERLLQGVQ-EMREQLDVAQRAYEDLEFQQ------LERESRQEEEDRD 253
Q +L + E++R+ L + + E EQ Q+ D E ++ LE E R+E+++R
Sbjct: 445 Q-RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 254 SPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQ 313
+ + +E Q Q LQ R+R E+QL+ EQ + L R++E+ L+
Sbjct: 504 EQQLRREQEERRE-QRLKRQEEEERLQQRLR-SEQQLRR--EQEERREQLLKREEEKRLE 559
Query: 314 ALSQER 319
+E+
Sbjct: 560 QERREQ 565
Score = 62.4 bits (150), Expect = 1e-09
Identities = 79/322 (24%), Positives = 133/322 (41%), Gaps = 38/322 (11%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+E Q + EQ+ + E R E++ E++ E R+ E
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ-------EERREQQERREQQEE 333
Query: 81 AATPPASTSSREGVRGAARRLQGQQL--EALTRVALMEQRVKELQRQ---RKELRIEMEV 135
E RR Q ++ + L R E+R ++L+R+ R+E ++ E
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 136 EV---------ALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQE 186
++ LR E R R E+QLR E++ ++ +++REQ +R +E
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 187 R-------DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQ 239
R + E Q RK Q + D Q E++RER L+ +E R R ++ Q
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLEEEER-------REQQERREQ 505
Query: 240 QLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAA 299
QL RE + E R Q + ++Q+ S Q RR + R ++L+ + + EQ
Sbjct: 506 QLRREQEERREQRLK--RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 300 ESRGLSRKKEEALQALSQERSR 321
E R ++E Q L +E R
Sbjct: 564 EQRLKREQEERRDQLLKREEER 585
Score = 61.2 bits (147), Expect = 3e-09
Identities = 76/292 (26%), Positives = 123/292 (42%), Gaps = 34/292 (11%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSS 90
+ RE E L + R QQ + +GE E R+ P
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGE--QQERDREQERRRWQQRDRHFPEEEQLE 1300
Query: 91 REGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVA 150
RE + A RR + Q E + L E+R ++ +RQ + + E ++ R E
Sbjct: 1301 REEQKEAKRRDRKSQEE---KQLLREEREEKRRRQETDRKFREEEQLLQEREE------Q 1351
Query: 151 ARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPED 210
R +E+ R+ E++ +++GR+ E+EQR QER+R + K + QL Q +
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER------KFLKEEQQLRCQERE 1405
Query: 211 QRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQAS 270
Q+ R + ++ RE+ R D +F++ E++ R++E +R K E +
Sbjct: 1406 QQLRQDRD-RKFREEEQQLSRQERDRKFREEEQQVRRQERER----------KFLEEEQQ 1454
Query: 271 MAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRK-KEEALQALSQERSR 321
+ Q R HR EEQL E+ + RK EE Q QER R
Sbjct: 1455 LRQER-----HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Score = 60.8 bits (146), Expect = 4e-09
Identities = 70/249 (28%), Positives = 114/249 (45%), Gaps = 27/249 (10%)
Query: 91 REGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL--RIEMEVEVALLRGELAGER 148
RE G + + ++LE R ++R +EL RQR+E R E E L+ G
Sbjct: 146 RELAEGEEQSEKQERLEQRDR----QRRDEELWRQRQEWQEREERRAEEEQLQS-CKGHE 200
Query: 149 VAARREEEQLR--ELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQR--LRKAQGQL 204
+EEQLR ELLE + + +QQR + Q R+ QE + E ++ LRK + +L
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 205 DSQPEDQRERLLQGVQEM----------REQLDVAQRAYEDLEFQQLERESRQEEEDRDS 254
+ E QR+R LQ +E RE+ + Q+ QQL R+ +E ++
Sbjct: 261 QEE-EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 255 PGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQA 314
+ + + Q+ + Q RR + R E+QL+ E+ E + L R++EE +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERR----EQQLRREQEEERREQQ-LRREQEEERRE 374
Query: 315 LSQERSRLL 323
R + L
Sbjct: 375 QQLRREQQL 383
Score = 59.3 bits (142), Expect = 1e-08
Identities = 75/322 (23%), Positives = 137/322 (42%), Gaps = 33/322 (10%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+E + + +E REQ+ E + ++Q EEE + + +E + +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQR-LKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTR--VALMEQRVKELQRQRKELRIEMEVEVA 138
+E +R Q ++ + L + +QR+K Q +R E R++ E
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 139 LLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQ--REQEQRR---LSQERDRLEGL 193
L + E +R+ EE+ R+ L + E+R +QQ REQ++RR L +E + E L
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERL 668
Query: 194 RQRL-------RKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERES- 245
QRL R+ Q + + E RER+ + + + QL+ A + + + ++
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 246 ---RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESR 302
RQE+E++ + + S Q + HR + EEQ + Q AE +
Sbjct: 729 QRRRQEQEEK------------RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 303 G-LSRKKEEALQALSQERSRLL 323
R++ A L ++R R L
Sbjct: 777 SERGRQRLSARPPLREQRERQL 798
Score = 58.9 bits (141), Expect = 1e-08
Identities = 62/221 (28%), Positives = 105/221 (47%), Gaps = 24/221 (10%)
Query: 114 LMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGR 173
L ++R +E QR+ + ++E E R + +R RE + E E+Q EQR R
Sbjct: 110 LQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ---KRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 174 QQREQE---QRRLSQERDRLEGLRQRLRKAQG-QLDSQPEDQ---RERLLQGVQEMREQL 226
Q+R++E QR+ QER+ ++L+ +G + + P+++ R LL+ ++ RE+
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 227 DVAQRAYEDLEFQQLERES--------RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGA 278
+R +D FQ+ E + R+EEE PQ + +ELQ Q R+
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ----RQRELQEEEEQLRKLE 282
Query: 279 LQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
Q R E Q + +Q + L RK+EE + +ER
Sbjct: 283 RQELRR--ERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Score = 58.5 bits (140), Expect = 2e-08
Identities = 83/318 (26%), Positives = 136/318 (42%), Gaps = 41/318 (12%)
Query: 29 PEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSR------DAPEATPPIAMAA 82
PE+ R QE + E E+Q EE + E R + + +
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 83 TPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQ-RKELRIEMEVEVALLR 141
RE LQ Q+ E L +R +EL+RQ RKE ++ E E LLR
Sbjct: 1038 REKRRLQERERQYREEEELQ-QEEEQLLGEERETRRRQELERQYRKEEELQQEEE-QLLR 1095
Query: 142 GELAGERVAAR----REEEQLRELLEQQAASEQRGRQQRE-----QEQRRLSQERDRL-- 190
E R R REEE+L++ EQ E+ R+++E +E+ + QE ++L
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 191 ---EGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY-EDLEFQQLERESR 246
E R++ + Q + + + + + E+LL+ QE R Q +R Y E+ E Q+ +R+ R
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ--ERERQYREEEELQRQKRKQR 1213
Query: 247 QEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSR 306
+ED+ S +P+ + + +G + R LE +S+ R
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE------------DSQLRDR 1261
Query: 307 KKEEALQAL---SQERSR 321
+ ++ LQ L QER R
Sbjct: 1262 QSQQDLQHLLGEQQERDR 1279
Score = 58.5 bits (140), Expect = 2e-08
Identities = 63/213 (29%), Positives = 105/213 (49%), Gaps = 19/213 (8%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQRGRQ 174
EQ++ +R RK L E ++ +L +R REEEQL +E EQQ ++R R+
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 175 QREQEQRRLSQERDR-LEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY 233
RE+EQ+ QER+R Q+LR+ + + + E+Q + + +EQL +R
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ-----ETEQEQLRRQERYR 1747
Query: 234 EDLEFQQL--ERES----RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLE 287
+ LE +QL ERE RQE + + Q+ + ++ S R+ + ++R
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 288 EQLKSLGEQMAAESR-GLSRKKEEALQALSQER 319
E+ +Q+ + R G R +EE LQ QE+
Sbjct: 1808 EE-----QQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/235 (28%), Positives = 108/235 (45%), Gaps = 39/235 (16%)
Query: 100 RLQGQQLEALTRVALMEQRVKELQRQ------RKELRIEMEVEVALLRGELAGERVAARR 153
R + QQL R Q ++L+RQ R+E ++ E E LR + ER
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ---ERYRKIL 1750
Query: 154 EEEQLR-ELLEQQAASEQRGRQQREQEQRRL--------SQERDRLEGLRQRLRKAQGQL 204
EEEQLR E EQQ ++R R+ RE+EQ R SQE DR ++LR+ + +
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 205 DSQP---------EDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDS 254
+P E+++ +L + Q +R++ D RA E Q+ R QE ++ +
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Query: 255 PGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKE 309
Q + K++E +H R R + E++ + +GE + E +G R E
Sbjct: 1871 KRRQERERKLRE------EHIR-----RQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 57.4 bits (137), Expect = 4e-08
Identities = 58/233 (24%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 104 QQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLE 163
QQL EQ+ ++ +R+E R++ E E R L E R E+E+ ++ L+
Sbjct: 423 QQLRREQEEERHEQKHEQ---ERREQRLKREQEER--RDWLKREEETERHEQERRKQQLK 477
Query: 164 QQAASEQRGRQQR-EQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQR--ERLLQGVQ 220
+ E+R R + E+E+RR QER + R++ + + +L Q E++R +RL Q
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 221 EMREQLDVAQRAYEDLEFQQLERESRQE--EEDRDSPGPQVPDPKVQELQASMAQHRRGA 278
REQ + ++ + E ++LE+E R++ + +++ Q+ + + Q + + +
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 279 LQHRIRVLEEQLKSLGEQMAAESRGLSR------KKEEALQALSQERSRLLEL 325
L+ R++ E+++ L ++ E R L R ++++ L++ QE R +L
Sbjct: 598 LEQRLK--REEVERLEQEERREQR-LKREEPEEERRQQLLKSEEQEERRQQQL 647
Score = 57.0 bits (136), Expect = 5e-08
Identities = 63/239 (26%), Positives = 112/239 (46%), Gaps = 30/239 (12%)
Query: 104 QQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREE-------- 155
Q+ E L R ++R++E +RQ +E E++ E L GE ER RR+E
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEE-ELQQEEEQLLGE---ERETRRRQELERQYRKE 1083
Query: 156 EQLRELLEQ--QAASEQRGRQQRE---QEQRRLSQERDRL-----EGLRQRLRKAQGQLD 205
E+L++ EQ + E+R RQ+RE +E+ L QE ++L E R++ + Q + +
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 206 SQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
+ + + E+LL+ E R + ++ ++ E+ E QQ E + +EE+++ + + +
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 266 ELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
ELQ + R E+Q L Q E R + + E+ R LE
Sbjct: 1204 ELQRQKRKQRYRD--------EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Score = 56.6 bits (135), Expect = 7e-08
Identities = 73/307 (23%), Positives = 131/307 (42%), Gaps = 21/307 (6%)
Query: 29 PEESREQEASEVLAEPSSRGGAEQQA--EEEEVGEGSSTESSRDAPEATPPIAMAATPPA 86
PEE + + + A+ R E++ EE + E+ R E + P
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 87 STSSREG-VRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA 145
R+ R R Q Q + L EQR++ +R+RK L+ E ++ +L
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEE----EQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 146 GERVAARREEEQLRELLEQ----QAASEQRGRQQRE----QEQRRLSQERDRLEGLRQRL 197
+R REEEQ E+ + +Q RQ+RE +E+++L QER R ++L
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 198 RKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEED--RDSP 255
+ + + +++ + L+ Q++R Q + ++L Q+ ER+ +EE+ R
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 256 GPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRK---KEEAL 312
+ + Q + Q RR + R EEQL+ E+ + RK +E+ +
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Query: 313 QALSQER 319
+ QER
Sbjct: 1589 RRQEQER 1595
Score = 55.1 bits (131), Expect = 2e-07
Identities = 70/244 (28%), Positives = 115/244 (47%), Gaps = 39/244 (15%)
Query: 99 RRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQL 158
++L QQ + + R +E +QR++ +R REEEQL
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQ------------------DRDRKFREEEQL 1563
Query: 159 R-ELLEQQAASEQRGRQQR--EQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQR--- 212
R E EQQ + ++R R+ R EQ+ RR QER +E Q+LR+ +GQ + E R
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED-EQQLRRQEGQQQLRQERDRKFR 1622
Query: 213 --ERLLQGVQEMREQLDVAQRAYEDLEFQ-QLERESRQEE--EDRDSPGPQ----VPDPK 263
E+LLQ +E +QL +R + LE + QL R+ R+++ DRD + + + +
Sbjct: 1623 EDEQLLQEREE--QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 264 VQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRK---KEEALQALSQERS 320
Q+L+ + + ++R E + K L E+ + L RK +E+ Q QE+
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 321 RLLE 324
R E
Sbjct: 1741 RRQE 1744
Score = 52.8 bits (125), Expect = 1e-06
Identities = 78/345 (22%), Positives = 142/345 (41%), Gaps = 52/345 (15%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
EE R+Q E + ++ E E E R+ PE + +
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVK---ELQRQRKEL--------RIEMEVEVA 138
++ +R + + Q+L+ +EQR+K E +R+ +EL R ++ +
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 139 LLRGELAGERVAA----------------RREEEQLRELLEQQAASEQRGRQ---QREQE 179
+ +L E A R+E+E+ R E + ++ R Q+E+E
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 180 QRR----LSQERDRLEGLRQRL-------RKAQGQLDSQPEDQRERLLQGVQEMREQLDV 228
QRR Q ++ E RQRL + + QL ++ QRE+ +E +EQ
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR- 821
Query: 229 AQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEE 288
QR + E Q LE E + + +R + D ++ + +Q +R + R ++ EE
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 289 QLK---------SLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+ + +L EQ+ E + L +++EE LQ +E+ R E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQ-LLQEEEEELQREEREKRRRQE 925
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/216 (23%), Positives = 103/216 (47%), Gaps = 19/216 (8%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQ 175
++R ++ Q Q +EL E E + E +R RR+EE R+ E Q E+R ++
Sbjct: 135 QRRRQKRQEQERELA---EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 176 REQE------QRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM--REQLD 227
+ Q + +E+ R L + RK + + Q ++++R+ Q +E R++
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 228 VAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLE 287
V ++ E L+ ++ +R+ +EE+ Q+ + QEL+ + + Q R+R E
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEE-----QLRKLERQELRRERQEEEQ--QQQRLR-RE 303
Query: 288 EQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLL 323
+QL+ E+ E + R+++E + + R + L
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQL 339
Score = 43.9 bits (102), Expect = 5e-04
Identities = 47/179 (26%), Positives = 82/179 (45%), Gaps = 26/179 (14%)
Query: 152 RREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQ 211
R+EE+Q R + E+ G+++R Q+R QER+ EG Q ++
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRR---QKRQEQERELAEGEEQ-------------SEK 157
Query: 212 RERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPG---PQVPDPKVQELQ 268
+ERL Q ++ R++ QR E+Q+ E +EE+ + G + PD + +
Sbjct: 158 QERLEQRDRQRRDEELWRQRQ----EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 269 ASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESR---GLSRKKEEALQALSQERSRLLE 324
+ R+G + + + E Q + E+ E R + RK+EE LQ +R R L+
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
>gi|203096856 kinesin family member 7 [Homo sapiens]
Length = 1343
Score = 73.6 bits (179), Expect = 5e-13
Identities = 112/440 (25%), Positives = 179/440 (40%), Gaps = 63/440 (14%)
Query: 12 PPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS-------- 63
PP +P +V + +G + + +E+L E + G A EEE E
Sbjct: 580 PPACLPGDEVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASEEEEEEEEPPRRTLHL 639
Query: 64 -----STESSR------DAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRV 112
S S R PE P A+ V G+ R+Q +Q+ T
Sbjct: 640 RRNRISNCSQRAGARPGSLPERKGPELCLEELDAAIPGSRAVGGSKARVQARQVPPATA- 698
Query: 113 ALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAA----RREEEQLREL---LEQQ 165
E R+ + Q++ +EL I + ++ L+ GEL AA R+ +++REL EQ
Sbjct: 699 --SEWRLAQAQQKIRELAINIRMKEELI-GELVRTGKAAQALNRQHSQRIRELEQEAEQV 755
Query: 166 AASEQRG-RQQREQEQRRLSQ--ERDRLEGLRQRLRKAQGQLDSQPEDQR--ERLLQGVQ 220
A G RQ RE E + L ER RL+ R+R+ AQ Q+ E ++ ERL+
Sbjct: 756 RAELSEGQRQLRELEGKELQDAGERSRLQEFRRRVAAAQSQVQVLKEKKQATERLVSLSA 815
Query: 221 EMREQLDVAQRAYEDLEFQ--QLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGA 278
+ ++L +R + + Q QL+R R+E E + + E + S QHR
Sbjct: 816 QSEKRLQELERNVQLMRQQQGQLQRRLREETEQK----------RRLEAEMSKRQHRVKE 865
Query: 279 LQHRIRVLEEQLKSLGEQMAAESR-------------GLSRKKEEALQALSQERSRLLEL 325
L+ + ++ LK E++AA R +K EE + L QE ++L+
Sbjct: 866 LELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQ 925
Query: 326 NCLQGTPGGDFSEPNPALTK--LLFTQKTDRQLLVLQDAVA-HSAATPTSSCLFSVHSSL 382
G + + L K L +KT + L+ + A + SS L + L
Sbjct: 926 RRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKEL 985
Query: 383 QGSIGLQRTGSLPRKRGERG 402
G R GS ++ RG
Sbjct: 986 SEKSGQLRQGSAQSQQQIRG 1005
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/262 (22%), Positives = 117/262 (44%), Gaps = 61/262 (23%)
Query: 102 QGQQLEALTRVALMEQRVKELQ----RQRKELRIEMEVEVALLRGELAG----------- 146
Q ++LEA ++ + RVKEL+ +Q+K L+I+ E A R +G
Sbjct: 848 QKRRLEA--EMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQ 905
Query: 147 ERVAARRE--EEQLRELLEQQAASEQRGRQQREQE-----QRRLSQER------------ 187
+++ +++ ++++ ++L+Q+ A E+ G + ++E + L QE+
Sbjct: 906 QKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQ 965
Query: 188 ----------DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLE 237
RLE L + L + GQL R+ Q Q++R ++D ++ + L
Sbjct: 966 ALNEDIVRVSSRLEHLEKELSEKSGQL-------RQGSAQSQQQIRGEIDSLRQEKDSLL 1018
Query: 238 FQQLERESRQEEEDRDSPGPQVP----DPKVQELQASMAQHRRGALQHRIRVLEEQLKSL 293
Q+LE + + + SP + D ++ L A++ +++ A+ R RVL L
Sbjct: 1019 KQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAI-EYKNEAITCRQRVLRASASLL 1077
Query: 294 GE---QMAAESRGLSRKKEEAL 312
+ + A+ LS + AL
Sbjct: 1078 SQCEMNLMAKLSYLSSSETRAL 1099
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 73.2 bits (178), Expect = 7e-13
Identities = 70/253 (27%), Positives = 119/253 (47%), Gaps = 37/253 (14%)
Query: 18 ECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPP 77
E V +Q + H + +R++ + E G E EEEEV E SS
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEE---EEEEVPEQEGEPSS--------- 342
Query: 78 IAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALM-EQRVKELQRQRKELRIEMEVE 136
+ P ST R+ +R ++ ++ EAL R L+ EQ+++E + +++L E +
Sbjct: 343 --IVNVPGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 137 VALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQR 196
+ +++EQ R L EQQ + RQQ +++RR +E+ RLE L +R
Sbjct: 399 I--------------EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 197 LRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPG 256
++ + + + E+++ R+ + + +R QL+ QR E L+ QQL +E D P
Sbjct: 445 RKEEEER--RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ-QQLLQEQAMLLHDHRRPH 501
Query: 257 P---QVPDPKVQE 266
P Q P P QE
Sbjct: 502 PQHSQQPPPPQQE 514
Score = 34.7 bits (78), Expect = 0.28
Identities = 50/211 (23%), Positives = 93/211 (44%), Gaps = 34/211 (16%)
Query: 123 QRQRKELRIEMEVEVALLRGELAGERVAARRE----EEQLRELLEQQAASEQ----RGRQ 174
Q +++RI+++ + R + GE+ E EE+ E+ EQ+ G
Sbjct: 292 QPNERQVRIQLKDHIDRTRKK-RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
Query: 175 QREQEQRRLSQE-RDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY 233
++ RL QE ++R E LR R++LLQ Q++REQ + ++
Sbjct: 351 TLRRDFLRLQQENKERSEALR-----------------RQQLLQE-QQLREQEEYKRQ-- 390
Query: 234 EDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSL 293
L ++ +R +Q+E+ R Q + + + Q + R + R+ LE + K
Sbjct: 391 --LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEE 448
Query: 294 GEQMAA--ESRGLSRKKEEALQALSQERSRL 322
E+ A E R + R++E + L +E+ L
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 73.2 bits (178), Expect = 7e-13
Identities = 70/253 (27%), Positives = 119/253 (47%), Gaps = 37/253 (14%)
Query: 18 ECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPP 77
E V +Q + H + +R++ + E G E EEEEV E SS
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEE---EEEEVPEQEGEPSS--------- 342
Query: 78 IAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALM-EQRVKELQRQRKELRIEMEVE 136
+ P ST R+ +R ++ ++ EAL R L+ EQ+++E + +++L E +
Sbjct: 343 --IVNVPGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 137 VALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQR 196
+ +++EQ R L EQQ + RQQ +++RR +E+ RLE L +R
Sbjct: 399 I--------------EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 197 LRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPG 256
++ + + + E+++ R+ + + +R QL+ QR E L+ QQL +E D P
Sbjct: 445 RKEEEER--RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ-QQLLQEQAMLLHDHRRPH 501
Query: 257 P---QVPDPKVQE 266
P Q P P QE
Sbjct: 502 PQHSQQPPPPQQE 514
Score = 34.7 bits (78), Expect = 0.28
Identities = 50/211 (23%), Positives = 93/211 (44%), Gaps = 34/211 (16%)
Query: 123 QRQRKELRIEMEVEVALLRGELAGERVAARRE----EEQLRELLEQQAASEQ----RGRQ 174
Q +++RI+++ + R + GE+ E EE+ E+ EQ+ G
Sbjct: 292 QPNERQVRIQLKDHIDRTRKK-RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
Query: 175 QREQEQRRLSQE-RDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY 233
++ RL QE ++R E LR R++LLQ Q++REQ + ++
Sbjct: 351 TLRRDFLRLQQENKERSEALR-----------------RQQLLQE-QQLREQEEYKRQ-- 390
Query: 234 EDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSL 293
L ++ +R +Q+E+ R Q + + + Q + R + R+ LE + K
Sbjct: 391 --LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEE 448
Query: 294 GEQMAA--ESRGLSRKKEEALQALSQERSRL 322
E+ A E R + R++E + L +E+ L
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/345 (24%), Positives = 157/345 (45%), Gaps = 35/345 (10%)
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQ---RVKELQRQRKELRIEM 133
P+ PA ++ + A +L+ ++ EA R E+ R +EL+RQ++E+
Sbjct: 707 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 766
Query: 134 EVEVALLRGELAGERVAARREEEQLRELLEQQAA----SEQRGRQQREQ------EQRRL 183
+ E R E E +A R++EE LR EQ+ A E+ RQQ+E+ E+RR
Sbjct: 767 QEEERKRREE---EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 823
Query: 184 SQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL-----DVAQRAYEDLEF 238
+ER + E L ++ + + + E+ + RL + M E+ + +R ++LE
Sbjct: 824 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 883
Query: 239 Q---QLERESRQEEE-----DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
Q +L R+ +Q++E + Q+ K+ Q A Q + + ++
Sbjct: 884 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 943
Query: 291 KSLGEQMAAESRGLSRKKE-EALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFT 349
+ L E+ + R R+++ E ++AL Q++ + + L G G+ S+P+ LL
Sbjct: 944 QKLEEERERQLREEQRRQQRELMKALQQQQQQ--QQQKLSG--WGNVSKPSGTTKSLLEI 999
Query: 350 QKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSL 394
Q+ + + + Q P + + HS+L SIG GS+
Sbjct: 1000 QQEEARQMQKQQQQQQQHQQP-NRARNNTHSNLHTSIGNSVWGSI 1043
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 19/246 (7%)
Query: 20 DVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQA---EEEEVGEGSSTESSRDAPEATP 76
+ E++ + EE + QE E R E++ EEEE+ E+ R E
Sbjct: 737 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE- 795
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVE 136
+A R+ A RRL+ ++ E R E K+ + K R E E +
Sbjct: 796 ---IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQ 852
Query: 137 VALLRGELAGERVAAR---REEEQLRELLEQQAASE-QRGRQQREQEQRRLSQERDRLEG 192
L L E AAR EEE+ R+ LE Q E R RQQ+++ RRL Q++ + +
Sbjct: 853 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 912
Query: 193 LRQRLRKAQ--GQLDSQPEDQRERLL-----QGVQEMRE-QLDVAQRAYEDLEFQQLERE 244
+ +L + GQ + Q + L Q ++E RE QL QR + + L+++
Sbjct: 913 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 972
Query: 245 SRQEEE 250
+Q+++
Sbjct: 973 QQQQQQ 978
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/345 (24%), Positives = 157/345 (45%), Gaps = 35/345 (10%)
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQ---RVKELQRQRKELRIEM 133
P+ PA ++ + A +L+ ++ EA R E+ R +EL+RQ++E+
Sbjct: 734 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 793
Query: 134 EVEVALLRGELAGERVAARREEEQLRELLEQQAA----SEQRGRQQREQ------EQRRL 183
+ E R E E +A R++EE LR EQ+ A E+ RQQ+E+ E+RR
Sbjct: 794 QEEERKRREE---EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 850
Query: 184 SQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL-----DVAQRAYEDLEF 238
+ER + E L ++ + + + E+ + RL + M E+ + +R ++LE
Sbjct: 851 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 910
Query: 239 Q---QLERESRQEEE-----DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
Q +L R+ +Q++E + Q+ K+ Q A Q + + ++
Sbjct: 911 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 970
Query: 291 KSLGEQMAAESRGLSRKKE-EALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFT 349
+ L E+ + R R+++ E ++AL Q++ + + L G G+ S+P+ LL
Sbjct: 971 QKLEEERERQLREEQRRQQRELMKALQQQQQQ--QQQKLSG--WGNVSKPSGTTKSLLEI 1026
Query: 350 QKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSL 394
Q+ + + + Q P + + HS+L SIG GS+
Sbjct: 1027 QQEEARQMQKQQQQQQQHQQP-NRARNNTHSNLHTSIGNSVWGSI 1070
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 19/246 (7%)
Query: 20 DVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQA---EEEEVGEGSSTESSRDAPEATP 76
+ E++ + EE + QE E R E++ EEEE+ E+ R E
Sbjct: 764 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE- 822
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVE 136
+A R+ A RRL+ ++ E R E K+ + K R E E +
Sbjct: 823 ---IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQ 879
Query: 137 VALLRGELAGERVAAR---REEEQLRELLEQQAASE-QRGRQQREQEQRRLSQERDRLEG 192
L L E AAR EEE+ R+ LE Q E R RQQ+++ RRL Q++ + +
Sbjct: 880 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 939
Query: 193 LRQRLRKAQ--GQLDSQPEDQRERLL-----QGVQEMRE-QLDVAQRAYEDLEFQQLERE 244
+ +L + GQ + Q + L Q ++E RE QL QR + + L+++
Sbjct: 940 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 999
Query: 245 SRQEEE 250
+Q+++
Sbjct: 1000 QQQQQQ 1005
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/345 (24%), Positives = 157/345 (45%), Gaps = 35/345 (10%)
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQ---RVKELQRQRKELRIEM 133
P+ PA ++ + A +L+ ++ EA R E+ R +EL+RQ++E+
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 134 EVEVALLRGELAGERVAARREEEQLRELLEQQAA----SEQRGRQQREQ------EQRRL 183
+ E R E E +A R++EE LR EQ+ A E+ RQQ+E+ E+RR
Sbjct: 773 QEEERKRREE---EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829
Query: 184 SQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL-----DVAQRAYEDLEF 238
+ER + E L ++ + + + E+ + RL + M E+ + +R ++LE
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889
Query: 239 Q---QLERESRQEEE-----DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
Q +L R+ +Q++E + Q+ K+ Q A Q + + ++
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949
Query: 291 KSLGEQMAAESRGLSRKKE-EALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFT 349
+ L E+ + R R+++ E ++AL Q++ + + L G G+ S+P+ LL
Sbjct: 950 QKLEEERERQLREEQRRQQRELMKALQQQQQQ--QQQKLSG--WGNVSKPSGTTKSLLEI 1005
Query: 350 QKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSL 394
Q+ + + + Q P + + HS+L SIG GS+
Sbjct: 1006 QQEEARQMQKQQQQQQQHQQP-NRARNNTHSNLHTSIGNSVWGSI 1049
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 19/246 (7%)
Query: 20 DVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQA---EEEEVGEGSSTESSRDAPEATP 76
+ E++ + EE + QE E R E++ EEEE+ E+ R E
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE- 801
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVE 136
+A R+ A RRL+ ++ E R E K+ + K R E E +
Sbjct: 802 ---IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQ 858
Query: 137 VALLRGELAGERVAAR---REEEQLRELLEQQAASE-QRGRQQREQEQRRLSQERDRLEG 192
L L E AAR EEE+ R+ LE Q E R RQQ+++ RRL Q++ + +
Sbjct: 859 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Query: 193 LRQRLRKAQ--GQLDSQPEDQRERLL-----QGVQEMRE-QLDVAQRAYEDLEFQQLERE 244
+ +L + GQ + Q + L Q ++E RE QL QR + + L+++
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 978
Query: 245 SRQEEE 250
+Q+++
Sbjct: 979 QQQQQQ 984
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/345 (24%), Positives = 157/345 (45%), Gaps = 35/345 (10%)
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQ---RVKELQRQRKELRIEM 133
P+ PA ++ + A +L+ ++ EA R E+ R +EL+RQ++E+
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 134 EVEVALLRGELAGERVAARREEEQLRELLEQQAA----SEQRGRQQREQ------EQRRL 183
+ E R E E +A R++EE LR EQ+ A E+ RQQ+E+ E+RR
Sbjct: 773 QEEERKRREE---EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829
Query: 184 SQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL-----DVAQRAYEDLEF 238
+ER + E L ++ + + + E+ + RL + M E+ + +R ++LE
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889
Query: 239 Q---QLERESRQEEE-----DRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
Q +L R+ +Q++E + Q+ K+ Q A Q + + ++
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949
Query: 291 KSLGEQMAAESRGLSRKKE-EALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFT 349
+ L E+ + R R+++ E ++AL Q++ + + L G G+ S+P+ LL
Sbjct: 950 QKLEEERERQLREEQRRQQRELMKALQQQQQQ--QQQKLSG--WGNVSKPSGTTKSLLEI 1005
Query: 350 QKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSL 394
Q+ + + + Q P + + HS+L SIG GS+
Sbjct: 1006 QQEEARQMQKQQQQQQQHQQP-NRARNNTHSNLHTSIGNSVWGSI 1049
Score = 54.7 bits (130), Expect = 3e-07
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 19/246 (7%)
Query: 20 DVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQA---EEEEVGEGSSTESSRDAPEATP 76
+ E++ + EE + QE E R E++ EEEE+ E+ R E
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE- 801
Query: 77 PIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVE 136
+A R+ A RRL+ ++ E R E K+ + K R E E +
Sbjct: 802 ---IALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQ 858
Query: 137 VALLRGELAGERVAAR---REEEQLRELLEQQAASE-QRGRQQREQEQRRLSQERDRLEG 192
L L E AAR EEE+ R+ LE Q E R RQQ+++ RRL Q++ + +
Sbjct: 859 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Query: 193 LRQRLRKAQ--GQLDSQPEDQRERLL-----QGVQEMRE-QLDVAQRAYEDLEFQQLERE 244
+ +L + GQ + Q + L Q ++E RE QL QR + + L+++
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 978
Query: 245 SRQEEE 250
+Q+++
Sbjct: 979 QQQQQQ 984
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 71.6 bits (174), Expect = 2e-12
Identities = 61/302 (20%), Positives = 125/302 (41%), Gaps = 4/302 (1%)
Query: 22 EVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA 81
E Q + + REQE E R Q E+E + +
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 82 ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLR 141
+EG G G+Q E + + +E R+++E E E +V
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 142 GELAGERVAARREEEQLRELLEQQAASEQRGRQQREQ--EQRRLSQERDRLEGLRQRLRK 199
++ + R++EEQ+RE EQ E++ +Q+EQ ++ + ++ +++ +++R+
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMRE 307
Query: 200 AQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQV 259
+ Q+ Q E RE+ Q ++ + + ++ +E E Q+ ++ Q E + Q
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKE--QMWKQEEQMGEQEEQMQKQE 365
Query: 260 PDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
+ QE Q + + + ++R EEQ+ EQM + + ++E+ + Q R
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 320 SR 321
+
Sbjct: 426 KQ 427
Score = 69.7 bits (169), Expect = 8e-12
Identities = 65/303 (21%), Positives = 128/303 (42%), Gaps = 13/303 (4%)
Query: 22 EVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA 81
E Q + + REQE E R Q E+E + +
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 180
Query: 82 ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLR 141
+EG G G+Q E M ++ +++Q+Q +++ E E ++
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQ------MGEQEEQMQKQEEQMG-EQEEQMRKQE 233
Query: 142 GELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQ 201
++ + +++EEQ+++ EQ E+ Q REQE++ QE L+ Q ++ Q
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMRKQEE---QMREQEEQMREQEEQMLKQKEQTEQEEQ 290
Query: 202 -GQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDL--EFQQLERESRQEEEDRDSPGPQ 258
G+ + Q +Q E++ + ++MREQ + + E + + +Q+ + Q E ++ Q
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350
Query: 259 VPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
QE Q + + + ++R EEQ++ EQM + + +KE+ + Q
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Query: 319 RSR 321
R +
Sbjct: 411 REQ 413
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/291 (25%), Positives = 130/291 (44%), Gaps = 27/291 (9%)
Query: 22 EVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA 81
E Q + + REQE +V + G E Q E+E G E + E M
Sbjct: 170 EGQVREQEGQVREQEG-QVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ-----MG 223
Query: 82 ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLR 141
E + ++Q Q+ + + M ++ ++++ Q +++R E E E L +
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMR-EQE-EQMLKQ 281
Query: 142 GELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQ 201
E + +EEQ+RE EQ E+ Q REQE++ QE +++ K +
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQMREQEE---QMREQEEQMREQE--------EQMGKQE 330
Query: 202 GQLDSQPE---DQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQ 258
Q+ Q E +Q+E++ + ++M EQ + Q+ E + Q+ E+ +QEE+ R Q
Sbjct: 331 EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE-EQMRKQEEQMRK----Q 385
Query: 259 VPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKE 309
+ QE Q + + G + ++R EEQ+ EQM + + +KE
Sbjct: 386 EEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 63.9 bits (154), Expect = 4e-10
Identities = 53/222 (23%), Positives = 106/222 (47%), Gaps = 11/222 (4%)
Query: 96 GAARRLQGQQLEALTRVALMEQRVKELQRQRKELR---IEMEVEVALLRGELAGERVAAR 152
G R +GQ E +V E +V+E + Q +E E E +V G++ + R
Sbjct: 108 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 167
Query: 153 REEEQLRELLEQQAASEQRGRQQREQ---EQRRLSQERDRLEGLRQRLRKAQGQLDSQPE 209
+E Q+RE Q E + R+Q Q ++ ++ ++ +++ ++++K + Q+ Q E
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 210 DQRERLLQ-GVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQ 268
R++ Q G QE + Q Q ++ + ++ E + R++EE Q+ K Q Q
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ 287
Query: 269 ASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEE 310
+ + G + ++R EEQ++ EQM + + ++E+
Sbjct: 288 ----EEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 96 GAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
G R +GQ E +V E +V+E + Q +E E +V G++ + R +E
Sbjct: 52 GQVREQEGQVREQEGQVREQEGQVREQEGQVRE----QEGQVREQEGQVREQEGQVREQE 107
Query: 156 EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERL 215
Q+RE ++ EQ G Q REQE + QE ++ ++R+ +GQ+ Q RE+
Sbjct: 108 GQVRE--QEGQVREQEG-QVREQEGQVREQE-GQVREQEGQVREQEGQVREQEGQVREQE 163
Query: 216 LQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHR 275
Q V+E Q+ + + E Q E+E + E++ G Q QE Q + +
Sbjct: 164 GQ-VREQEGQVREQEGQVREQEGQVREQEGQMGEQE-GQMGEQEEQMGEQEEQMQKQEEQ 221
Query: 276 RGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSR 321
G + ++R EEQ+ EQ+ + + +++E+ + Q R +
Sbjct: 222 MGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267
Score = 54.3 bits (129), Expect = 3e-07
Identities = 55/228 (24%), Positives = 105/228 (46%), Gaps = 19/228 (8%)
Query: 101 LQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALL---------RGELAGERVAA 151
L+ + E + L+E E+Q KEL+ ++E + L G++ +
Sbjct: 9 LKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQV 68
Query: 152 RREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQP 208
R +E Q+RE Q E + R+Q Q + + Q R++ +R+ ++R+ +GQ+ Q
Sbjct: 69 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 128
Query: 209 EDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESR---QEEEDRDSPG---PQVPDP 262
RE+ Q V+E Q+ + + E Q E+E + QE + R+ G Q
Sbjct: 129 GQVREQEGQ-VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 263 KVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEE 310
+ QE Q + + G + ++ EEQ++ EQM + + +++E+
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQ 235
Score = 39.3 bits (90), Expect = 0.011
Identities = 35/160 (21%), Positives = 69/160 (43%), Gaps = 7/160 (4%)
Query: 18 ECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPP 77
+ + E Q E+ REQE E R EQ E+EE G E + E
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEE-QMGKQEEQMWEQKE---- 338
Query: 78 IAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEV 137
M E + ++Q Q+ + + M ++ +++++Q +++R + E ++
Sbjct: 339 -QMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMR-KQEEQM 396
Query: 138 ALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQRE 177
+ ++ ++ R +EEQ+ E EQ E+ +Q+E
Sbjct: 397 GEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 71.2 bits (173), Expect = 3e-12
Identities = 73/276 (26%), Positives = 130/276 (47%), Gaps = 47/276 (17%)
Query: 18 ECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPP 77
E V +Q + H + +R++ + E G E EEEEV E SS
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEE---EEEEVPEQEGEPSS--------- 342
Query: 78 IAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALM-EQRVKELQRQRKELRIEMEVE 136
+ P ST R+ +R ++ ++ EAL R L+ EQ+++E + +++L E +
Sbjct: 343 --IVNVPGESTLRRDFLR--LQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 137 VALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQR 196
+ +++EQ R L EQQ + RQQ +++RR +E+ RLE L +R
Sbjct: 399 I--------------EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 197 LRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERES-------RQEE 249
++ + + + E+++ R+ + + +R QL+ QR E L+ Q L+ ++ R+ E
Sbjct: 445 RKEEEER--RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREME 502
Query: 250 EDRDSPGPQVPDPKVQELQASMA----QHRRGALQH 281
E R + Q ++Q+ QA + HRR QH
Sbjct: 503 EHRQAERLQ---RQLQQEQAYLLSLQHDHRRPHPQH 535
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 69.7 bits (169), Expect = 8e-12
Identities = 85/351 (24%), Positives = 147/351 (41%), Gaps = 52/351 (14%)
Query: 9 EGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSS-----------------RGGAE 51
+ P L E + P+G PE +E E A S G E
Sbjct: 482 QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKE 541
Query: 52 QQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTR 111
Q ++ EE+G G +A + +A++ TPP S VR +QL
Sbjct: 542 QHSQAEELGPGQE-----EAEDPEEKVAVSPTPPVSPE----VRSTEPVAPPEQLSEAAL 592
Query: 112 VALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQ--QAASE 169
A+ E + L++ ++ L + ++ LR +L E EEE++ L +Q Q+ S
Sbjct: 593 KAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQE------EEEEILRLHQQKEQSLSS 646
Query: 170 QRGRQQR---EQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ--GVQEMRE 224
R R Q+ E+E R +E RL LR AQ Q +Q ++ + R Q +Q++RE
Sbjct: 647 LRERLQKAIEEEEARMREEESQRLSWLR-----AQVQSSTQADEDQIRAEQEASLQKLRE 701
Query: 225 QLDVAQRAYE-DLE------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRG 277
+L+ Q+A LE +QL+ E E+ + + +Q+L+ + R+
Sbjct: 702 ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKE 761
Query: 278 ALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCL 328
A+ + +L+ L + A+ R + ++ +Q Q+ L+ CL
Sbjct: 762 AVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQ-KCL 811
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/331 (24%), Positives = 140/331 (42%), Gaps = 32/331 (9%)
Query: 13 PPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAP 72
P L C QP G ++ Q + + L S+G E+ + E + + A
Sbjct: 431 PVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLAT 490
Query: 73 EATPPIAMAATPPASTSSREGVRGAAR---RLQGQQLEALTRVALMEQRVKELQRQRKEL 129
E PP P + G AA +L Q+ +A + A E + KE Q +EL
Sbjct: 491 EEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACE-KGKEQHSQAEEL 549
Query: 130 ------RIEMEVEVALLRGELAGERVAARREEEQLRELLEQQ-AASEQRGRQQREQEQRR 182
+ E +VA+ V + +L E A E+ Q EQ+QR
Sbjct: 550 GPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH 609
Query: 183 -LSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQL 241
L ++++++ LR++L + + + + Q+E Q + +RE+L Q+A E+ E +
Sbjct: 610 LLESKQEKMQQLREKLCQEEEEEILRLHQQKE---QSLSSLRERL---QKAIEEEEARMR 663
Query: 242 ERESR-------------QEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEE 288
E ES+ Q +ED+ + K++E S + R +L+ + R + E
Sbjct: 664 EEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLE 723
Query: 289 QLK-SLGEQMAAESRGLSRKKEEALQALSQE 318
QLK + +E L+ KE+ALQ L ++
Sbjct: 724 QLKEEIEASEKSEQAALNAAKEKALQQLREQ 754
Score = 46.2 bits (108), Expect = 9e-05
Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 60/320 (18%)
Query: 63 SSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALT----------RV 112
SST++ D A ++ S ++ R + + Q LE L +
Sbjct: 679 SSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQA 738
Query: 113 ALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE--RVAARREEEQLRELLEQQAASEQ 170
AL + K LQ+ R++L E + VA L E + E R+ + E + RE++ Q
Sbjct: 739 ALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH-REVVSSLQKKIQ 797
Query: 171 RGRQQRE--------QEQRRLSQERDRLEG--------LRQRLRKAQGQLDSQPEDQRER 214
+Q+ E Q + R+ Q+ + G LR++ ++ +G+ + + + +E
Sbjct: 798 EAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEE 857
Query: 215 LLQGVQEMREQ-------------------LDVAQRAYE-DLEFQQLERESRQEEEDRDS 254
Q + + REQ L+ QRA+E +LE + E+ R E+ R
Sbjct: 858 HQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRH 917
Query: 255 PGPQVPDPKVQELQASMAQHRRG--ALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEA- 311
+ + K+Q+L+ + + A + V EE + +Q+ R ++ K EEA
Sbjct: 918 ---REQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEAT 974
Query: 312 -----LQALSQERSRLLELN 326
L+ +E + LL+ N
Sbjct: 975 ATHQQLEEAQKEHTHLLQSN 994
Score = 43.5 bits (101), Expect = 6e-04
Identities = 62/255 (24%), Positives = 102/255 (40%), Gaps = 40/255 (15%)
Query: 94 VRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARR 153
+R + ++G+ L ++ Q+V + + R++ E + A L G L GE +R
Sbjct: 836 LREKRQEVEGEHERRLDKMKEEHQQV--MAKAREQYEAEERKQRAELLGHLTGELERLQR 893
Query: 154 EEEQLRELLEQQAASEQRGRQQREQEQRRLSQERD-----RLEGLRQRL----------- 197
E+ E + Q+ ++R +EQ R Q+ + R + ++ RL
Sbjct: 894 AHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETAR 953
Query: 198 RKAQGQLDSQ-----------------PEDQRE--RLLQGVQEMREQLDVAQRAYEDLEF 238
R+ Q LD Q E Q+E LLQ Q++RE LD Q LE
Sbjct: 954 REKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLES 1013
Query: 239 QQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVL--EEQLKSLGEQ 296
Q +++ ++ + + K Q L + A H L E+ KSLG
Sbjct: 1014 QVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTN 1073
Query: 297 MAAE-SRGLSRKKEE 310
E S LS+ KE+
Sbjct: 1074 QTKEVSSSLSQSKED 1088
Score = 38.1 bits (87), Expect = 0.025
Identities = 61/253 (24%), Positives = 105/253 (41%), Gaps = 41/253 (16%)
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERV 149
S + +R LQ ++L+ ++V L++ + ++LQ+ L E + + LLR E
Sbjct: 993 SNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENN 1052
Query: 150 AARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERD--RLEGLRQ----RLRKAQGQ 203
A+ E L + + G Q ++ LSQ ++ L+ L L A+G
Sbjct: 1053 ASPHFEPD----LHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEG- 1107
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
+E L+Q + MR + Q A + + + +E +D PG +
Sbjct: 1108 --VALRSAKEFLVQQTRSMRRR----QTALKAAQQHWRHELASAQEVAKDPPGIK----- 1156
Query: 264 VQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRG--LSRKKEEALQALSQERSR 321
AL+ + LE++ + L E +A +G L +KKEE L+Q S
Sbjct: 1157 --------------ALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEE---KLNQLESS 1199
Query: 322 LLELNCLQGTPGG 334
L E +GT GG
Sbjct: 1200 LWEEASDEGTLGG 1212
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 69.7 bits (169), Expect = 8e-12
Identities = 79/320 (24%), Positives = 126/320 (39%), Gaps = 52/320 (16%)
Query: 6 SPEEG-TPPPLVPEC-DVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
SP G T PP P P+G E + S A P + ++++A E+
Sbjct: 483 SPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAP 542
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGV-----------------RGAARRLQGQQL 106
++ + AP TP PPA T + V G R + +L
Sbjct: 543 ASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRL 602
Query: 107 EALTRVALMEQRVKELQRQR------KELRIEMEVEVALLRGELAGERVAARREEEQLRE 160
A R EQR +E Q +R K +R E A R E E A RREE++ RE
Sbjct: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAE--ARRREEQEARE 660
Query: 161 LLEQQAASEQRGRQQREQ---------EQRRLSQE-------------RDRLEGLRQRLR 198
+ + ++R ++Q+E+ E++RL +E R RLE + +R R
Sbjct: 661 KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTR 720
Query: 199 KAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDS-PGP 257
K++ Q +D +E G E + + L+ + +++E +E + S P
Sbjct: 721 KSEVSETKQKQDSKEANANG--SSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
Query: 258 QVPDPKVQELQASMAQHRRG 277
++P V LQ A G
Sbjct: 779 ELPASLVNGLQPLPAHQENG 798
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/210 (23%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 4 RSSPE--EGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGG--AEQQAEEEEV 59
R SPE PPP + + P P + ++ EP S G + A +E
Sbjct: 26 RPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEE 85
Query: 60 GEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV 119
S +S P A P A PP +S A + E V +R
Sbjct: 86 SPSSEAKSRGPTPPAMGP--RDARPPRRSSQPSPTAVPASDSPPTKQE----VKKAGERH 139
Query: 120 KELQRQRKELRIEMEVEVAL-LRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQ 178
K + +R+E + + A+ L E + + ++ +E+ R L EQ+ +EQR E+
Sbjct: 140 KLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEER 199
Query: 179 EQRRLSQERDRLEGLRQR-LRKAQGQLDSQ 207
++++L + ++R E QR ++K ++ Q
Sbjct: 200 QRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
Score = 33.1 bits (74), Expect = 0.81
Identities = 27/115 (23%), Positives = 49/115 (42%)
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQ 247
DR E R K + + + +++ER LQ ++ R + + R E ++ E R+
Sbjct: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
Query: 248 EEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESR 302
E+E R+ + + + + Q A+ R R R+ E+ EQ E R
Sbjct: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERR 709
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/243 (25%), Positives = 123/243 (50%), Gaps = 15/243 (6%)
Query: 88 TSSREGVRGAARRLQGQQLEALTRVALMEQRV------KELQRQRKELRIEMEVEVALLR 141
T++R A+ Q Q+ A ++A+ Q K+L+++R+E R + E A
Sbjct: 285 TANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKE 344
Query: 142 GELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQ 201
EL + +E +L+EL Q A Q R +E+E+RR SQ R+ + L +LR+A+
Sbjct: 345 EELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAE 404
Query: 202 ---GQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQ 258
+ ++ E + E + Q ++E ++ QR E L QLE ++R++EE +
Sbjct: 405 QARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL---QLEVKARRDEESVRIAQTR 461
Query: 259 VPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ + + ++L+ M + + I +++ + L ++MA +SR L + +++ L+ + Q
Sbjct: 462 LLEEEEEKLKQLM--QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQ-LEEVRQN 518
Query: 319 RSR 321
R R
Sbjct: 519 RQR 521
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/261 (23%), Positives = 119/261 (45%), Gaps = 26/261 (9%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +E++ E+ ++ AE+ +EEE S + A E + A AS
Sbjct: 354 QEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ--LREAEQARASMQ 411
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVA---------- 138
+ ++ Q Q+++ L M+QR++E LQ + K R E V +A
Sbjct: 412 AEMELKEEEAARQRQRIKELEE---MQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEE 468
Query: 139 ----LLRGELAGERVA--ARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEG 192
L++ + ER A++E+E+L++ + QQ+ S Q+ +QQ E+ ++ + + +E
Sbjct: 469 KLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEA 528
Query: 193 LRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQL-ERESRQEEED 251
+++LR+A + Q RL+ + E ++ V ++ + L R+S +
Sbjct: 529 AQRKLRQASTNV-KHWNVQMNRLMHPI-EPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLT 586
Query: 252 R-DSPGPQVPDPKVQELQASM 271
R S G + P P E Q S+
Sbjct: 587 RWGSQGNRTPSPNSNEQQKSL 607
Score = 36.2 bits (82), Expect = 0.095
Identities = 30/100 (30%), Positives = 40/100 (40%), Gaps = 11/100 (11%)
Query: 536 RGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQA--IEEVYYDHLRC 593
+G L K G + W +RWF Q L Y+ +E + +G+I A EV D
Sbjct: 220 QGYLWKRGHLRRNWAERWF--QLQPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDR--- 274
Query: 594 AFKSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTA 633
R FCVKT R + M A + W I A
Sbjct: 275 ----DGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMA 310
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 68.6 bits (166), Expect = 2e-11
Identities = 72/231 (31%), Positives = 120/231 (51%), Gaps = 28/231 (12%)
Query: 118 RVKELQRQRKELRIEMEVEVALLRGELAGERVAA---RREEEQLRELLEQQAASEQRGRQ 174
+V++LQ + LR E+E L+ E+ ++ + RR+EE+LRE E+ E+R
Sbjct: 158 KVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEER--- 214
Query: 175 QREQEQR------RLSQERDRLEGLRQRLRKAQGQLDSQPE---DQRERLLQGVQEM--R 223
EQE+R RL ++ +RL +RLR+ + +L Q E +Q ERL + + + +
Sbjct: 215 LHEQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLCEQ 274
Query: 224 EQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL---QASMAQHRRGALQ 280
E+L +R E++E + LE+E RQEE++R ++ D +V+EL + Q R Q
Sbjct: 275 EKLPGQERLLEEVE-KLLEQERRQEEQERLLERERLLD-EVEELLEQERLRQQDERLWQQ 332
Query: 281 HRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELN 326
+R LE E+L+ L E++ R L E + ++ RS ELN
Sbjct: 333 ETLRELERLRELERLREL-ERLRELERMLELGWEALYEQRAEPRSGFEELN 382
Score = 54.3 bits (129), Expect = 3e-07
Identities = 65/260 (25%), Positives = 113/260 (43%), Gaps = 34/260 (13%)
Query: 80 MAATPPASTSSREGVRGAARRLQ------GQQLEALTR----VALMEQRVKELQRQRKEL 129
+A PPA S E ++ L+ G+QL+A ++L+ +R +E R+++E
Sbjct: 148 LAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEER 207
Query: 130 RIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQR----EQEQRRLSQ 185
E E + L + +EE+LRE E+ E+R +Q EQE+R Q
Sbjct: 208 LHEQEERLHEQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQ 267
Query: 186 -----ERDRLEGLRQRLRKAQGQLDSQ-PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQ 239
E+++L G + L + + L+ + ++++ERLL E LD + E +
Sbjct: 268 EERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLL----ERERLLDEVEELLEQERLR 323
Query: 240 QLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAA 299
Q + Q+E R+ +++EL+ R L+ R+LE ++L EQ A
Sbjct: 324 QQDERLWQQETLREL-------ERLRELERLRELERLRELE---RMLELGWEALYEQRAE 373
Query: 300 ESRGLSRKKEEALQALSQER 319
G E L E+
Sbjct: 374 PRSGFEELNNENKSTLQLEQ 393
Score = 30.4 bits (67), Expect = 5.2
Identities = 41/155 (26%), Positives = 62/155 (40%), Gaps = 13/155 (8%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E R E E L E G E+ EE E + E ++ E
Sbjct: 260 QEERLCEQEERLCEQEKLPGQERLLEEVE--KLLEQERRQEEQERLLERERLLDEVEELL 317
Query: 90 SREGVRGAARRL-QGQQLEALTRVALMEQRVKELQRQRK---------ELRIEMEVEVAL 139
+E +R RL Q + L L R+ +E R++EL+R R+ E E E
Sbjct: 318 EQERLRQQDERLWQQETLRELERLRELE-RLRELERLRELERMLELGWEALYEQRAEPRS 376
Query: 140 LRGELAGERVAARREEEQLRELLEQQAASEQRGRQ 174
EL E + + E+Q++EL + A E RG +
Sbjct: 377 GFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSE 411
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 67.8 bits (164), Expect = 3e-11
Identities = 78/340 (22%), Positives = 149/340 (43%), Gaps = 26/340 (7%)
Query: 45 SSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATP--PASTSSREGVRGAARRLQ 102
S G E E EE+ S+ + I+ ++ A + E +R + R+ Q
Sbjct: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
Query: 103 GQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL- 161
+ E+L + +R+ E R R++L +E+ ++ G A E+ R+ ++ ++
Sbjct: 1888 -EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDG-YADEKTLFERQIQEKTDII 1945
Query: 162 --LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ-- 217
LEQ+ Q+ E EQ+++ +ER+ L ++ ++ G ++ Q + E+L++
Sbjct: 1946 DRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 2005
Query: 218 -----GVQEMREQLDVAQRAYE-DLE-----FQQLERESRQEEEDRDSPGPQVPDP---- 262
+++R+ L +A E D+E F +LE+E E D +
Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM 2065
Query: 263 -KVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSR 321
K + QA +H R Q I+ LE+QLK + + S +R+ E+ L ++ +
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVV-PRFQPISEHQTREVEQLANHLKEKTDK 2124
Query: 322 LLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQD 361
EL + D E N + KL F + Q L+++D
Sbjct: 2125 CSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVED 2164
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/262 (20%), Positives = 115/262 (43%), Gaps = 27/262 (10%)
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIE---------MEVEVALL 140
S +G + + L+ + E +A + ++EL R+ +E+R+ E E A+
Sbjct: 146 SEQGAQDSPTHLEMMESE----LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK 201
Query: 141 RGE------LAGERVAARREEEQLRELLEQQAASEQ---RGRQQREQEQRRLSQERDRLE 191
+ + A + A R ++E +RE LE S++ + +Q + E R S
Sbjct: 202 QRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA 261
Query: 192 GLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEED 251
L Q K Q Q ++++ LL+ Q+ +E + Q ++ + + E E ++ E+
Sbjct: 262 DLLQA--KQQILTHQQQLEEQDHLLEDYQKKKEDFTM-QISFLQEKIKVYEMEQDKKVEN 318
Query: 252 RDSPGPQVPDPKVQELQASMAQHRRGALQ--HRIRVLEEQLKSLGEQMAAESRGLSRKKE 309
+ Q + ++EL + + + L+ ++ ++ L L EQ+ +++ + K
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378
Query: 310 EALQALSQERSRLLELNCLQGT 331
E + +ER E+ L GT
Sbjct: 379 ELTNSKQKERQSSEEIKQLMGT 400
Score = 43.1 bits (100), Expect = 8e-04
Identities = 52/255 (20%), Positives = 109/255 (42%), Gaps = 14/255 (5%)
Query: 107 EALTRVALMEQRVKE--------LQRQRKELRIEMEVEVALLRGELAGERVAARREEEQL 158
+A+ + +EQR++E ++ +K R + E+ L ++ G ++ +RE+E
Sbjct: 3048 DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE 3107
Query: 159 RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQG 218
+ E + Q+ + Q + Q LS +DR L+++L + + + + L Q
Sbjct: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV----AELKSELAQT 3163
Query: 219 VQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRR-- 276
E+ L + ++LE +LE + + +E + K +ELQ ++ + +
Sbjct: 3164 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3223
Query: 277 GALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDF 336
G + R + E LK E + L+ E+ Q L++ + ++ L +
Sbjct: 3224 GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE 3283
Query: 337 SEPNPALTKLLFTQK 351
N L LL ++K
Sbjct: 3284 QGRNLELQVLLESEK 3298
Score = 38.1 bits (87), Expect = 0.025
Identities = 57/268 (21%), Positives = 113/268 (42%), Gaps = 24/268 (8%)
Query: 85 PASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGEL 144
P S V A L+ + + + EQ +++Q + +E+ ++E V L L
Sbjct: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE-KLEFRVRELEQAL 2160
Query: 145 AGERVAARREEEQLREL-LEQQAASEQRGRQQREQE----QRRLSQERDRLEGLRQRLRK 199
E E EL LE Q +E+ ++E+E + +L Q R+ LE + +++
Sbjct: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2220
Query: 200 AQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQV 259
QL+ Q ++ RL + QE + D ++ L ++ + S Q++ Q+
Sbjct: 2221 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKL--GLAIKESDAMSTQDQHVLFGKFAQI 2278
Query: 260 PDPKVQELQASMAQHRRGALQHRIRVLEEQLK-SLGEQMAAESRGLSRKKEEALQALSQE 318
+QE + + Q L ++ L++QLK + ++ E L R E ++ L +
Sbjct: 2279 ----IQEKEVEIDQ-----LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2329
Query: 319 RSRLLELNCLQGTPGGDFSEPNPALTKL 346
+ C++ + + N + KL
Sbjct: 2330 Q------ECVKRNREEEIEQLNEVIEKL 2351
Score = 38.1 bits (87), Expect = 0.025
Identities = 57/249 (22%), Positives = 106/249 (42%), Gaps = 42/249 (16%)
Query: 112 VALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQR 171
++ + R+ EL+ Q +EM + L + ++ +A + E+ ++LLE Q E
Sbjct: 2593 ISALTLRISELESQV----VEMHTSLILEKEQV---EIAEKNVLEKEKKLLELQKLLEGN 2645
Query: 172 GRQQREQEQRRLSQERD-------------------RLEGLRQRLRKAQGQLDSQPED-- 210
++QRE+E++R Q+ + LE LR + +L S E
Sbjct: 2646 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2705
Query: 211 --QRERLLQGVQEMREQLDVAQ------RAYEDLEFQQLERESRQEEEDRDSPGPQVPDP 262
Q E L++ Q D++Q A E L LE+E E E ++S + +P
Sbjct: 2706 KLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI--LEKE--DETEVQESKKACMFEP 2761
Query: 263 KVQELQASMAQHRRGALQHRIRVLEEQL--KSLGEQMAAESRGLSRKKEEALQALSQERS 320
+L S+A G L+ Q+ K+ G Q+ +S S + E + +++
Sbjct: 2762 LPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE 2821
Query: 321 RLLELNCLQ 329
++ EL+ +
Sbjct: 2822 KMQELHAAE 2830
Score = 36.2 bits (82), Expect = 0.095
Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 59/255 (23%)
Query: 112 VALMEQRVKELQRQRKELRIEMEVEVALL-------RGELAGERVAARREEE---QLREL 161
V L+ + Q++ +EL+ +E E A L + EL + + +++ QL L
Sbjct: 3195 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254
Query: 162 LEQQAA----SEQRGRQQREQEQRRLSQERDR-------LEGLRQRLRKAQGQLD----- 205
LEQQ S+Q+ QR +LS+E+ R LE + R+R+ LD
Sbjct: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314
Query: 206 ------------SQPEDQRERLLQGVQEMREQ----------------LDVAQRAYEDLE 237
S+P E LL+ +Q+ E+ LD Q + +
Sbjct: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3374
Query: 238 FQQLERESRQEEEDRDSPGPQVP---DPKVQELQASMAQHRRGALQHRIRVLEEQLKSLG 294
+Q+ R++ Q E++ ++ G + KV++LQ + + R+ +++ + ++L+ +
Sbjct: 3375 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV--YKLDLEGQRLQGIM 3432
Query: 295 EQMAAESRGLSRKKE 309
++ + K+E
Sbjct: 3433 QEFQKQELEREEKRE 3447
Score = 34.7 bits (78), Expect = 0.28
Identities = 55/299 (18%), Positives = 120/299 (40%), Gaps = 14/299 (4%)
Query: 101 LQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGE--LAGERVAARREEEQL 158
L+ + E + L+E+++KE + +E ++E E ++L+ E + + Q
Sbjct: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800
Query: 159 RELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPED---QRERL 215
L+ + + E+E L +E E L+Q+ + +++ Q +
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEEN---EDLKQQCIQLNEEIEKQRNTFSFAEKNF 857
Query: 216 LQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHR 275
QE++E+ + +DLE + +++QE E + + +Q + + + +
Sbjct: 858 EVNYQELQEEYACLLKVKDDLE----DSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913
Query: 276 RGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGD 335
+ E L+ +GE + ++ L K E + + RL +L+ G+
Sbjct: 914 SSVFDEDKTFVAETLE-MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
Query: 336 FSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGS 393
S N + L ++ + L+ + H+ A SC V S L G + + G+
Sbjct: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGA 1031
Score = 34.3 bits (77), Expect = 0.36
Identities = 40/174 (22%), Positives = 76/174 (43%), Gaps = 8/174 (4%)
Query: 155 EEQLRELLEQQAASEQ-RGRQQREQEQRRLSQE--RDRLEGLRQRLRKAQGQLDSQPEDQ 211
+E +R+ E Q A+E R R+ E++R QE ++ ++ L ++L + + +
Sbjct: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651
Query: 212 RERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQV-----PDPKVQE 266
RER+L E +QL +A R E + +++ E++ Q D K ++
Sbjct: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPED 1711
Query: 267 LQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
+ + + R ALQ L + L + + AA + R L S+ +S
Sbjct: 1712 VPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
Score = 31.2 bits (69), Expect = 3.1
Identities = 22/93 (23%), Positives = 48/93 (51%), Gaps = 17/93 (18%)
Query: 205 DSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKV 264
+ Q ED R+ L++ QE ++ ++ ++A+ +Q+ER+ +E+ ++ ++
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQATELLRQAH----MRQMERQREDQEQLQE---------EI 1630
Query: 265 QELQASMAQH----RRGALQHRIRVLEEQLKSL 293
+ L +AQ + R RVL E+L++L
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEAL 1663
Score = 30.0 bits (66), Expect = 6.8
Identities = 47/222 (21%), Positives = 96/222 (43%), Gaps = 24/222 (10%)
Query: 111 RVALMEQRVK-----ELQRQRKELRIEMEVEVALLRGELAGERVAARREEE--QLRELLE 163
+V ++Q++K ++ ++ EL ++E ++ L + E V REEE QL E++E
Sbjct: 2292 QVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ--ECVKRNREEEIEQLNEVIE 2349
Query: 164 QQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMR 223
+ Q+ LS+E D L+ + + L+ Q E E + ++
Sbjct: 2350 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLK 2409
Query: 224 EQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRI 283
E + ++L + ERES ++ + +P+ V +++ + + +
Sbjct: 2410 ETNFKMNQLTQELFSLKRERESVEKIQ-------SIPENSVNVAIDHLSKDKP---ELEV 2459
Query: 284 RVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ E+ LKSL Q +S +E ++ +RLL+L
Sbjct: 2460 VLTEDALKSLENQTYFKS-----FEENGKGSIINLETRLLQL 2496
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 67.8 bits (164), Expect = 3e-11
Identities = 92/333 (27%), Positives = 148/333 (44%), Gaps = 46/333 (13%)
Query: 25 PQGHP-EESREQEASEVLAEPSSRGGAEQQAEEEEV--GEGSSTESSRDAPEATPPIAMA 81
P G P ++S ++ + L + G A QA+E+E+ +G E + EA A
Sbjct: 477 PAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAAT 536
Query: 82 ATPPASTSSR-EGVRGAARRLQGQQLEALTRVALM----EQRVKELQRQRKELRIEMEVE 136
A+ + SS+ E R A R L+ Q +V + EQR++E Q K + E
Sbjct: 537 ASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEE-SSQAKTIHTASETN 595
Query: 137 VALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQ----QREQEQRRLSQERDRLEG 192
+ E + R+E LRE LEQ + G++ Q ++E RRLS+E++RLE
Sbjct: 596 -GMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEA 654
Query: 193 -------LRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERES 245
+QRL + + +S E Q +L V + + R Y Q L +
Sbjct: 655 ELAQEQESKQRLEGERRETESNWEAQLADILSWVND-----EKVSRGY----LQALATKM 705
Query: 246 RQEEEDRDSPGPQV----------PDPKVQELQASMAQHRRGALQHRIRV---LEEQLKS 292
+E E + G Q ++Q+++AS + AL+ IR L+E+L
Sbjct: 706 AEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQ 765
Query: 293 LGE-QMAAESRGLSRKKEEALQALSQERSRLLE 324
+ E Q+ AE R ++ E+ QAL QE + L E
Sbjct: 766 VQEAQLQAERR--LQEAEKQSQALQQELAMLRE 796
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 41/329 (12%)
Query: 31 ESREQEASEVLAEPSS-----RGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA---- 81
+ +EQE + L + S RG AE E E + ++ R+A ++ + A
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 82 ------------ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL 129
A A +E + AARR Q +Q + A + K + + L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 130 RIEMEVEVALLRGELAGERVAARRE--EEQLRELLEQQAASEQRGRQQREQEQRRLSQER 187
R + +VE L L E ++ +E+L+ L + +A R R Q E+E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAARQRSQVEEELFSVRVQM 2237
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL--DVAQRAYEDLEFQQLERES 245
+ L L+ R+ L + +D +R LQ E +Q+ + A+ + E +L + +
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 246 RQEEEDRDSPGPQVPDPKVQELQ--------ASMAQHRRGALQHRIRVLEEQLKSLGEQM 297
++ + + ++ K+Q +Q A + Q ++ Q + R L+E + + +Q+
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 298 AAESRGLSRKKEEALQALSQERSRLLELN 326
A E++G R L ER R LE++
Sbjct: 2358 AEETQGFQR-------TLEAERQRQLEMS 2379
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 35/285 (12%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +EQ A + LAE + +AE + E S+ A A A +
Sbjct: 2347 QEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQR--------KELRIEMEVEVALLR 141
R+ +L +L +V L++ E+QRQ+ +E E+E E L+
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQ--TLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 142 GE-----LAGERVAARREEEQLREL--LEQQAASEQRGRQQREQEQRRLSQERDRLEGL- 193
E L E + ++E+ L+E L+Q SE+ QRE R + QE+ +LE L
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE---RFIEQEKAKLEQLF 2520
Query: 194 ------RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY--EDLEFQQLERES 245
Q+LR+ Q + Q E +R+RL+ ++E R + A+ + E QQLE++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 246 RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
RQ+EE ++ ++LQ QH R AL H V Q+
Sbjct: 2581 RQQEELLAEENQRLR----EQLQLLEEQH-RAALAHSEEVTASQV 2620
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 45/259 (17%)
Query: 50 AEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEAL 109
AEQQ + EV EG +R + EA +A+ PA+ + R + +L+ Q+ +L
Sbjct: 1024 AEQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE--QVRSL 1080
Query: 110 TRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL-------- 161
+ + L + + L ++RG E V R EEQL+E
Sbjct: 1081 SAIYLEKLKTISL----------------VIRGTQGAEEVL-RAHEEQLKEAQAVPATLP 1123
Query: 162 -LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQPEDQRER--- 214
LE AS ++ R Q E +Q RD L G ++ RL++ G+ D + E RER
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK-----VQELQA 269
LL+ Q + Q DV QR E +QL R+ R E D G + D + +Q +
Sbjct: 1184 LLERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 270 SMAQHRRGALQHRIRVLEE 288
+ +Q R L+ +LEE
Sbjct: 1239 ADSQAVREQLRQEQALLEE 1257
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/293 (22%), Positives = 133/293 (45%), Gaps = 17/293 (5%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIA--MAATPPAST 88
E + E E LAE + E+Q + E + ++ R+A E + + A+
Sbjct: 1352 EQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 89 SSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA-GE 147
+++ R LQ QL + + + + +R LRIE E+ V L+ E +
Sbjct: 1410 DAQQQKRSIQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 148 RVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQ 207
R A E + LR E+ A +++ +++ E+ +R++ E R L ++ + +++
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAE 1526
Query: 208 PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL 267
+++R LQ ++E+R Q + A+R +Q E E ++ + + + ++Q
Sbjct: 1527 AAREKQRALQALEELRLQAEEAER-----RLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 268 QASMAQHRRGALQHRIR---VLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+AS A+ + L+ ++ V QL+ E+ A + R +EEA + L +
Sbjct: 1582 RASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 22/307 (7%)
Query: 34 EQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREG 93
E A L E + R A+QQAE E E + E R +A + + +
Sbjct: 1599 EHVAVAQLREEAERR-AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 94 VRGAARRLQGQ-QLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE----R 148
+ A + + + + EA R EQ V++ + +EL + ++ + LA E R
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 149 VAARREE-EQLRELLEQQAASEQR----GRQQREQEQRRLSQERDRLEGLRQRLRKAQGQ 203
+ A E+ EQ R+LLE++ A QR Q+R++ + L++ R +E L +A+ +
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
S E ++RL RE + A R E + +R+ +E+ R +
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERV 1834
Query: 264 VQELQASMAQHRRGALQHRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ E A++ + R + I + E E+L+ L E A + R R +E+A Q +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---RLEEQAAQHKADI 1891
Query: 319 RSRLLEL 325
RL +L
Sbjct: 1892 EERLAQL 1898
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 35/261 (13%)
Query: 97 AARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
AAR Q + + + AL E+ +KE +Q ++ R++ E E+ + ELA E+ +E+
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 156 -EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
EQ+ + L ++ QR + Q Q +S E +RL+ + +AQ + + + R++
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 215 --------------------LLQGVQEMREQLD-VAQRAYEDLEFQQLERESRQEE---- 249
L+Q ++ R+Q D A+R E + + E+E Q+E
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 250 ----EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ---LKSLGEQMAAESR 302
E+ + + + Q LQ S + LQ R R +E++ L+ L + A+++
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 303 GLSRKKEEALQALSQERSRLL 323
L +++ Q + QER RL+
Sbjct: 2529 QLREEQQRQQQQMEQERQRLV 2549
Score = 56.6 bits (135), Expect = 7e-08
Identities = 79/296 (26%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ---GQQLE 107
E A++ + E E + EAT + A +E + ARRLQ Q +
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEAT---RLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 108 ALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG-ERVAARREEEQLRELLEQQA 166
L QR E +RQR ++EM E L+ +A R AR EE+ R + +
Sbjct: 2356 QLAEETQGFQRTLEAERQR---QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 167 ASEQRGRQQREQEQR-----RLSQERDRLEGLRQRLRKAQGQLDSQPE--DQRERLLQGV 219
E+ R + +++ L +R + + +RLR+A +L+ + E Q +LLQ
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 220 QEMREQLDVAQRAYEDLEFQQ---------LERESRQEEEDRDSPGP-QVPDPKVQELQA 269
E + + Q E QQ L+RE E+E Q K Q+L+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ ++ Q R R++ ++ Q AE G+ RK+EE LQ L Q+R + EL
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEE-LQQLEQQRRQQEEL 2586
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 43/322 (13%)
Query: 20 DVEVQPQGHPEESREQ-EASEVL---AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEAT 75
+ VQ + +SR Q E +E L AE ++ A+ QA E++ + + E++R A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 76 PPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV--------KELQRQRK 127
+ A + R + Q + LT + L + +ELQR +
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 128 E-----------------LRIEMEVEVALLRGELAGE-RVAARREEEQLRELLEQQAASE 169
E +R++ME E++ L+ + E R R+++ + L+++A
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQME-ELSKLKARIEAENRALILRDKDNTQRFLQEEAEK- 2272
Query: 170 QRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVA 229
+Q +E RLS LRQ + Q + E + +Q VQE A
Sbjct: 2273 ---MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Query: 230 QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ 289
+ + E Q ++R+ +ED++ Q+ + + Q Q ++ R+ L+ + +
Sbjct: 2330 ELLQQQKELAQ--EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLE-----MSAE 2381
Query: 290 LKSLGEQMAAESRGLSRKKEEA 311
+ L ++A SR +R +E+A
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDA 2403
Score = 50.1 bits (118), Expect = 6e-06
Identities = 69/347 (19%), Positives = 135/347 (38%), Gaps = 50/347 (14%)
Query: 4 RSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
RS+ E+ E + Q Q EE R + +E + S AE++A +
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL--AAEEEAARQRKAALE 2009
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ 123
E + E + A ++ + A +RLQ ++ V EQ +++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 124 RQRK---------------------ELRIEMEVEVALLRGELAGERVAARREEEQLRELL 162
+Q + E R++ E E A R ++ + EEQ +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 163 EQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM 222
+ QAA+E+ ++ ++ RR E+ LRQ+ + A +++ + + L Q Q +
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQ---AALRQK-QAADAEMEKHKKFAEQTLRQKAQ-V 2184
Query: 223 REQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQ-- 280
++L + E+ + Q+ + D ++Q L+A + R Q
Sbjct: 2185 EQELTTLRLQLEETDHQK-----------------NLLDEELQRLKAEATEAARQRSQVE 2227
Query: 281 ---HRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+RV E+L L ++ AE+R L + ++ Q QE + ++
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Score = 49.3 bits (116), Expect = 1e-05
Identities = 81/367 (22%), Positives = 139/367 (37%), Gaps = 65/367 (17%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+ ++ + E + Q E LA A Q +E E + + + A+ A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ-------RQRKEL---- 129
+ S S++ + A R + EA AL E+ ++ Q RQR E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 130 -----------RIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQ------- 170
R++ E E+AL E ER+ E+E R LE+QAA +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 171 ----------------------RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
R R+Q E+E L ++ + L G++ S
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 209 EDQRERLLQGVQEMREQLDVA---QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
ED Q E Q +A +R + E + + + +EE R + +V+
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR---KAALEEVE 2012
Query: 266 ELQASMAQHRR---GALQHRIRVLEEQLKSLGEQMAAESR----GLSRKKEEALQALSQE 318
L+A + + RR A Q R L+ ++ +++ AE + + +K++E Q L QE
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 319 RSRLLEL 325
+S L +L
Sbjct: 2073 QSVLDQL 2079
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/349 (23%), Positives = 135/349 (38%), Gaps = 32/349 (9%)
Query: 158 LRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ 217
+ E L + E+ QQR +E+ RL++ LE RQ L +A Q +Q E + + L Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQ 1395
Query: 218 GVQE---MREQLDV-AQRAYEDL--EFQQLERES--------RQEEEDRDSPGPQVPDPK 263
+QE RE+ V AQ+ + E QQL + S RQ E S + +
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 264 VQELQASMAQHRRGALQHRIRVLE---EQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
V LQ + +RG + ++ L E+ ++ Q E+ L R+ ++ Q Q
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 321 RLLELNCLQGTPGGDFSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVH 379
L + + AL +L L ++ +R+L + A + S
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 380 SSLQGSIG--LQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLY 437
+ LQ ++T L R E R E E A A + R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLR-------EEAERRAQQQAEAERAREEAE 1628
Query: 438 QLLNCGRGNSCGAIH----PDIAHMERLLQQAMAERERLLKAREGTRRG 482
+ L + + A+ + ++ L QA AE+++ RE RRG
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRG-ELAGERVAARRE-EEQLREL---LEQQAASEQ 170
E+R+ E QR + R+ EVE AL + +LA A+ + E + +EL ++++ +
Sbjct: 1347 EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405
Query: 171 RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ 230
+Q++R + +E +L + +A+ + E R R+ + ++ +R QL+ +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 231 RAYEDLE---------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQH 281
R E ++ E + RQ +E+ + QV D ++ QA +
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--------- 1516
Query: 282 RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
L ++K+ E + R L +E LQA ER
Sbjct: 1517 ----LASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Score = 46.6 bits (109), Expect = 7e-05
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 156 EQLRELLEQQAASEQRGRQ-QREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
E LR + E E+R + QR +E+ RL++ LE RQ L +A Q +Q E + +
Sbjct: 1339 ETLRRMEE-----EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1392
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDSPGPQVPDPKVQELQASMAQ 273
L Q +QE +V +R ++ QQ +R ++E ++ R S ++ + + QA A+
Sbjct: 1393 LQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKARQAEAAE 1444
Query: 274 HRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
R ++ IRV+ QL++ Q L + A +A +Q+R
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 41/329 (12%)
Query: 31 ESREQEASEVLAEPSS-----RGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA---- 81
+ +EQE + L + S RG AE E E + ++ R+A ++ + A
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 82 ------------ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL 129
A A +E + AARR Q +Q + A + K + + L
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 130 RIEMEVEVALLRGELAGERVAARRE--EEQLRELLEQQAASEQRGRQQREQEQRRLSQER 187
R + +VE L L E ++ +E+L+ L + +A R R Q E+E + +
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAARQRSQVEEELFSVRVQM 2241
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL--DVAQRAYEDLEFQQLERES 245
+ L L+ R+ L + +D +R LQ E +Q+ + A+ + E +L + +
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 246 RQEEEDRDSPGPQVPDPKVQELQ--------ASMAQHRRGALQHRIRVLEEQLKSLGEQM 297
++ + + ++ K+Q +Q A + Q ++ Q + R L+E + + +Q+
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 298 AAESRGLSRKKEEALQALSQERSRLLELN 326
A E++G R L ER R LE++
Sbjct: 2362 AEETQGFQR-------TLEAERQRQLEMS 2383
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 35/285 (12%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +EQ A + LAE + +AE + E S+ A A A +
Sbjct: 2351 QEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQR--------KELRIEMEVEVALLR 141
R+ +L +L +V L++ E+QRQ+ +E E+E E L+
Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQ--TLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 142 GE-----LAGERVAARREEEQLREL--LEQQAASEQRGRQQREQEQRRLSQERDRLEGL- 193
E L E + ++E+ L+E L+Q SE+ QRE R + QE+ +LE L
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE---RFIEQEKAKLEQLF 2524
Query: 194 ------RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY--EDLEFQQLERES 245
Q+LR+ Q + Q E +R+RL+ ++E R + A+ + E QQLE++
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 246 RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
RQ+EE ++ ++LQ QH R AL H V Q+
Sbjct: 2585 RQQEELLAEENQRLR----EQLQLLEEQH-RAALAHSEEVTASQV 2624
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 45/259 (17%)
Query: 50 AEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEAL 109
AEQQ + EV EG +R + EA +A+ PA+ + R + +L+ Q+ +L
Sbjct: 1028 AEQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE--QVRSL 1084
Query: 110 TRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL-------- 161
+ + L + + L ++RG E V R EEQL+E
Sbjct: 1085 SAIYLEKLKTISL----------------VIRGTQGAEEVL-RAHEEQLKEAQAVPATLP 1127
Query: 162 -LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQPEDQRER--- 214
LE AS ++ R Q E +Q RD L G ++ RL++ G+ D + E RER
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK-----VQELQA 269
LL+ Q + Q DV QR E +QL R+ R E D G + D + +Q +
Sbjct: 1188 LLERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1242
Query: 270 SMAQHRRGALQHRIRVLEE 288
+ +Q R L+ +LEE
Sbjct: 1243 ADSQAVREQLRQEQALLEE 1261
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/293 (22%), Positives = 133/293 (45%), Gaps = 17/293 (5%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIA--MAATPPAST 88
E + E E LAE + E+Q + E + ++ R+A E + + A+
Sbjct: 1356 EQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 89 SSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA-GE 147
+++ R LQ QL + + + + +R LRIE E+ V L+ E +
Sbjct: 1414 DAQQQKRSIQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 148 RVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQ 207
R A E + LR E+ A +++ +++ E+ +R++ E R L ++ + +++
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAE 1530
Query: 208 PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL 267
+++R LQ ++E+R Q + A+R +Q E E ++ + + + ++Q
Sbjct: 1531 AAREKQRALQALEELRLQAEEAER-----RLRQAEVERARQVQVALETAQRSAEAELQSK 1585
Query: 268 QASMAQHRRGALQHRIR---VLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+AS A+ + L+ ++ V QL+ E+ A + R +EEA + L +
Sbjct: 1586 RASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 22/307 (7%)
Query: 34 EQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREG 93
E A L E + R A+QQAE E E + E R +A + + +
Sbjct: 1603 EHVAVAQLREEAERR-AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661
Query: 94 VRGAARRLQGQ-QLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE----R 148
+ A + + + + EA R EQ V++ + +EL + ++ + LA E R
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1721
Query: 149 VAARREE-EQLRELLEQQAASEQR----GRQQREQEQRRLSQERDRLEGLRQRLRKAQGQ 203
+ A E+ EQ R+LLE++ A QR Q+R++ + L++ R +E L +A+ +
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
S E ++RL RE + A R E + +R+ +E+ R +
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERV 1838
Query: 264 VQELQASMAQHRRGALQHRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ E A++ + R + I + E E+L+ L E A + R R +E+A Q +
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---RLEEQAAQHKADI 1895
Query: 319 RSRLLEL 325
RL +L
Sbjct: 1896 EERLAQL 1902
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 35/261 (13%)
Query: 97 AARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
AAR Q + + + AL E+ +KE +Q ++ R++ E E+ + ELA E+ +E+
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2353
Query: 156 -EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
EQ+ + L ++ QR + Q Q +S E +RL+ + +AQ + + + R++
Sbjct: 2354 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2413
Query: 215 --------------------LLQGVQEMREQLD-VAQRAYEDLEFQQLERESRQEE---- 249
L+Q ++ R+Q D A+R E + + E+E Q+E
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 250 ----EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ---LKSLGEQMAAESR 302
E+ + + + Q LQ S + LQ R R +E++ L+ L + A+++
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 303 GLSRKKEEALQALSQERSRLL 323
L +++ Q + QER RL+
Sbjct: 2533 QLREEQQRQQQQMEQERQRLV 2553
Score = 56.6 bits (135), Expect = 7e-08
Identities = 79/296 (26%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ---GQQLE 107
E A++ + E E + EAT + A +E + ARRLQ Q +
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEAT---RLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359
Query: 108 ALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG-ERVAARREEEQLRELLEQQA 166
L QR E +RQR ++EM E L+ +A R AR EE+ R + +
Sbjct: 2360 QLAEETQGFQRTLEAERQR---QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 167 ASEQRGRQQREQEQR-----RLSQERDRLEGLRQRLRKAQGQLDSQPE--DQRERLLQGV 219
E+ R + +++ L +R + + +RLR+A +L+ + E Q +LLQ
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 220 QEMREQLDVAQRAYEDLEFQQ---------LERESRQEEEDRDSPGP-QVPDPKVQELQA 269
E + + Q E QQ L+RE E+E Q K Q+L+
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ ++ Q R R++ ++ Q AE G+ RK+EE LQ L Q+R + EL
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEE-LQQLEQQRRQQEEL 2590
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 43/322 (13%)
Query: 20 DVEVQPQGHPEESREQ-EASEVL---AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEAT 75
+ VQ + +SR Q E +E L AE ++ A+ QA E++ + + E++R A
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Query: 76 PPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV--------KELQRQRK 127
+ A + R + Q + LT + L + +ELQR +
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218
Query: 128 E-----------------LRIEMEVEVALLRGELAGE-RVAARREEEQLRELLEQQAASE 169
E +R++ME E++ L+ + E R R+++ + L+++A
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQME-ELSKLKARIEAENRALILRDKDNTQRFLQEEAEK- 2276
Query: 170 QRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVA 229
+Q +E RLS LRQ + Q + E + +Q VQE A
Sbjct: 2277 ---MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2333
Query: 230 QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ 289
+ + E Q ++R+ +ED++ Q+ + + Q Q ++ R+ L+ + +
Sbjct: 2334 ELLQQQKELAQ--EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLE-----MSAE 2385
Query: 290 LKSLGEQMAAESRGLSRKKEEA 311
+ L ++A SR +R +E+A
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDA 2407
Score = 50.1 bits (118), Expect = 6e-06
Identities = 69/347 (19%), Positives = 135/347 (38%), Gaps = 50/347 (14%)
Query: 4 RSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
RS+ E+ E + Q Q EE R + +E + S AE++A +
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL--AAEEEAARQRKAALE 2013
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ 123
E + E + A ++ + A +RLQ ++ V EQ +++
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 124 RQRK---------------------ELRIEMEVEVALLRGELAGERVAARREEEQLRELL 162
+Q + E R++ E E A R ++ + EEQ +
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 163 EQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM 222
+ QAA+E+ ++ ++ RR E+ LRQ+ + A +++ + + L Q Q +
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQ---AALRQK-QAADAEMEKHKKFAEQTLRQKAQ-V 2188
Query: 223 REQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQ-- 280
++L + E+ + Q+ + D ++Q L+A + R Q
Sbjct: 2189 EQELTTLRLQLEETDHQK-----------------NLLDEELQRLKAEATEAARQRSQVE 2231
Query: 281 ---HRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+RV E+L L ++ AE+R L + ++ Q QE + ++
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Score = 49.3 bits (116), Expect = 1e-05
Identities = 81/367 (22%), Positives = 139/367 (37%), Gaps = 65/367 (17%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+ ++ + E + Q E LA A Q +E E + + + A+ A
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ-------RQRKEL---- 129
+ S S++ + A R + EA AL E+ ++ Q RQR E
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839
Query: 130 -----------RIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQ------- 170
R++ E E+AL E ER+ E+E R LE+QAA +
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 171 ----------------------RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
R R+Q E+E L ++ + L G++ S
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959
Query: 209 EDQRERLLQGVQEMREQLDVA---QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
ED Q E Q +A +R + E + + + +EE R + +V+
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR---KAALEEVE 2016
Query: 266 ELQASMAQHRR---GALQHRIRVLEEQLKSLGEQMAAESR----GLSRKKEEALQALSQE 318
L+A + + RR A Q R L+ ++ +++ AE + + +K++E Q L QE
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076
Query: 319 RSRLLEL 325
+S L +L
Sbjct: 2077 QSVLDQL 2083
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/349 (23%), Positives = 135/349 (38%), Gaps = 32/349 (9%)
Query: 158 LRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ 217
+ E L + E+ QQR +E+ RL++ LE RQ L +A Q +Q E + + L Q
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQ 1399
Query: 218 GVQE---MREQLDV-AQRAYEDL--EFQQLERES--------RQEEEDRDSPGPQVPDPK 263
+QE RE+ V AQ+ + E QQL + S RQ E S + +
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 264 VQELQASMAQHRRGALQHRIRVLE---EQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
V LQ + +RG + ++ L E+ ++ Q E+ L R+ ++ Q Q
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 321 RLLELNCLQGTPGGDFSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVH 379
L + + AL +L L ++ +R+L + A + S
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 380 SSLQGSIG--LQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLY 437
+ LQ ++T L R E R E E A A + R
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLR-------EEAERRAQQQAEAERAREEAE 1632
Query: 438 QLLNCGRGNSCGAIH----PDIAHMERLLQQAMAERERLLKAREGTRRG 482
+ L + + A+ + ++ L QA AE+++ RE RRG
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRG-ELAGERVAARRE-EEQLREL---LEQQAASEQ 170
E+R+ E QR + R+ EVE AL + +LA A+ + E + +EL ++++ +
Sbjct: 1351 EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1409
Query: 171 RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ 230
+Q++R + +E +L + +A+ + E R R+ + ++ +R QL+ +
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 231 RAYEDLE---------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQH 281
R E ++ E + RQ +E+ + QV D ++ QA +
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--------- 1520
Query: 282 RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
L ++K+ E + R L +E LQA ER
Sbjct: 1521 ----LASRVKAEAEAAREKQRALQALEELRLQAEEAER 1554
Score = 46.6 bits (109), Expect = 7e-05
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 156 EQLRELLEQQAASEQRGRQ-QREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
E LR + E E+R + QR +E+ RL++ LE RQ L +A Q +Q E + +
Sbjct: 1343 ETLRRMEE-----EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1396
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDSPGPQVPDPKVQELQASMAQ 273
L Q +QE +V +R ++ QQ +R ++E ++ R S ++ + + QA A+
Sbjct: 1397 LQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKARQAEAAE 1448
Query: 274 HRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
R ++ IRV+ QL++ Q L + A +A +Q+R
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 41/329 (12%)
Query: 31 ESREQEASEVLAEPSS-----RGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA---- 81
+ +EQE + L + S RG AE E E + ++ R+A ++ + A
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 82 ------------ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL 129
A A +E + AARR Q +Q + A + K + + L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 130 RIEMEVEVALLRGELAGERVAARRE--EEQLRELLEQQAASEQRGRQQREQEQRRLSQER 187
R + +VE L L E ++ +E+L+ L + +A R R Q E+E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAARQRSQVEEELFSVRVQM 2237
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL--DVAQRAYEDLEFQQLERES 245
+ L L+ R+ L + +D +R LQ E +Q+ + A+ + E +L + +
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 246 RQEEEDRDSPGPQVPDPKVQELQ--------ASMAQHRRGALQHRIRVLEEQLKSLGEQM 297
++ + + ++ K+Q +Q A + Q ++ Q + R L+E + + +Q+
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 298 AAESRGLSRKKEEALQALSQERSRLLELN 326
A E++G R L ER R LE++
Sbjct: 2358 AEETQGFQR-------TLEAERQRQLEMS 2379
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 35/285 (12%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +EQ A + LAE + +AE + E S+ A A A +
Sbjct: 2347 QEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQR--------KELRIEMEVEVALLR 141
R+ +L +L +V L++ E+QRQ+ +E E+E E L+
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQ--TLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 142 GE-----LAGERVAARREEEQLREL--LEQQAASEQRGRQQREQEQRRLSQERDRLEGL- 193
E L E + ++E+ L+E L+Q SE+ QRE R + QE+ +LE L
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE---RFIEQEKAKLEQLF 2520
Query: 194 ------RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY--EDLEFQQLERES 245
Q+LR+ Q + Q E +R+RL+ ++E R + A+ + E QQLE++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 246 RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
RQ+EE ++ ++LQ QH R AL H V Q+
Sbjct: 2581 RQQEELLAEENQRLR----EQLQLLEEQH-RAALAHSEEVTASQV 2620
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 45/259 (17%)
Query: 50 AEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEAL 109
AEQQ + EV EG +R + EA +A+ PA+ + R + +L+ Q+ +L
Sbjct: 1024 AEQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE--QVRSL 1080
Query: 110 TRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL-------- 161
+ + L + + L ++RG E V R EEQL+E
Sbjct: 1081 SAIYLEKLKTISL----------------VIRGTQGAEEVL-RAHEEQLKEAQAVPATLP 1123
Query: 162 -LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQPEDQRER--- 214
LE AS ++ R Q E +Q RD L G ++ RL++ G+ D + E RER
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK-----VQELQA 269
LL+ Q + Q DV QR E +QL R+ R E D G + D + +Q +
Sbjct: 1184 LLERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 270 SMAQHRRGALQHRIRVLEE 288
+ +Q R L+ +LEE
Sbjct: 1239 ADSQAVREQLRQEQALLEE 1257
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/293 (22%), Positives = 133/293 (45%), Gaps = 17/293 (5%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIA--MAATPPAST 88
E + E E LAE + E+Q + E + ++ R+A E + + A+
Sbjct: 1352 EQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 89 SSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA-GE 147
+++ R LQ QL + + + + +R LRIE E+ V L+ E +
Sbjct: 1410 DAQQQKRSIQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 148 RVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQ 207
R A E + LR E+ A +++ +++ E+ +R++ E R L ++ + +++
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAE 1526
Query: 208 PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL 267
+++R LQ ++E+R Q + A+R +Q E E ++ + + + ++Q
Sbjct: 1527 AAREKQRALQALEELRLQAEEAER-----RLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 268 QASMAQHRRGALQHRIR---VLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+AS A+ + L+ ++ V QL+ E+ A + R +EEA + L +
Sbjct: 1582 RASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 22/307 (7%)
Query: 34 EQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREG 93
E A L E + R A+QQAE E E + E R +A + + +
Sbjct: 1599 EHVAVAQLREEAERR-AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 94 VRGAARRLQGQ-QLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE----R 148
+ A + + + + EA R EQ V++ + +EL + ++ + LA E R
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 149 VAARREE-EQLRELLEQQAASEQR----GRQQREQEQRRLSQERDRLEGLRQRLRKAQGQ 203
+ A E+ EQ R+LLE++ A QR Q+R++ + L++ R +E L +A+ +
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
S E ++RL RE + A R E + +R+ +E+ R +
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERV 1834
Query: 264 VQELQASMAQHRRGALQHRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ E A++ + R + I + E E+L+ L E A + R R +E+A Q +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---RLEEQAAQHKADI 1891
Query: 319 RSRLLEL 325
RL +L
Sbjct: 1892 EERLAQL 1898
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 35/261 (13%)
Query: 97 AARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
AAR Q + + + AL E+ +KE +Q ++ R++ E E+ + ELA E+ +E+
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 156 -EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
EQ+ + L ++ QR + Q Q +S E +RL+ + +AQ + + + R++
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 215 --------------------LLQGVQEMREQLD-VAQRAYEDLEFQQLERESRQEE---- 249
L+Q ++ R+Q D A+R E + + E+E Q+E
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 250 ----EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ---LKSLGEQMAAESR 302
E+ + + + Q LQ S + LQ R R +E++ L+ L + A+++
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 303 GLSRKKEEALQALSQERSRLL 323
L +++ Q + QER RL+
Sbjct: 2529 QLREEQQRQQQQMEQERQRLV 2549
Score = 56.6 bits (135), Expect = 7e-08
Identities = 79/296 (26%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ---GQQLE 107
E A++ + E E + EAT + A +E + ARRLQ Q +
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEAT---RLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 108 ALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG-ERVAARREEEQLRELLEQQA 166
L QR E +RQR ++EM E L+ +A R AR EE+ R + +
Sbjct: 2356 QLAEETQGFQRTLEAERQR---QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 167 ASEQRGRQQREQEQR-----RLSQERDRLEGLRQRLRKAQGQLDSQPE--DQRERLLQGV 219
E+ R + +++ L +R + + +RLR+A +L+ + E Q +LLQ
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 220 QEMREQLDVAQRAYEDLEFQQ---------LERESRQEEEDRDSPGP-QVPDPKVQELQA 269
E + + Q E QQ L+RE E+E Q K Q+L+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ ++ Q R R++ ++ Q AE G+ RK+EE LQ L Q+R + EL
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEE-LQQLEQQRRQQEEL 2586
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 43/322 (13%)
Query: 20 DVEVQPQGHPEESREQ-EASEVL---AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEAT 75
+ VQ + +SR Q E +E L AE ++ A+ QA E++ + + E++R A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 76 PPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV--------KELQRQRK 127
+ A + R + Q + LT + L + +ELQR +
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 128 E-----------------LRIEMEVEVALLRGELAGE-RVAARREEEQLRELLEQQAASE 169
E +R++ME E++ L+ + E R R+++ + L+++A
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQME-ELSKLKARIEAENRALILRDKDNTQRFLQEEAEK- 2272
Query: 170 QRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVA 229
+Q +E RLS LRQ + Q + E + +Q VQE A
Sbjct: 2273 ---MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Query: 230 QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ 289
+ + E Q ++R+ +ED++ Q+ + + Q Q ++ R+ L+ + +
Sbjct: 2330 ELLQQQKELAQ--EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLE-----MSAE 2381
Query: 290 LKSLGEQMAAESRGLSRKKEEA 311
+ L ++A SR +R +E+A
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDA 2403
Score = 50.1 bits (118), Expect = 6e-06
Identities = 69/347 (19%), Positives = 135/347 (38%), Gaps = 50/347 (14%)
Query: 4 RSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
RS+ E+ E + Q Q EE R + +E + S AE++A +
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL--AAEEEAARQRKAALE 2009
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ 123
E + E + A ++ + A +RLQ ++ V EQ +++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 124 RQRK---------------------ELRIEMEVEVALLRGELAGERVAARREEEQLRELL 162
+Q + E R++ E E A R ++ + EEQ +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 163 EQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM 222
+ QAA+E+ ++ ++ RR E+ LRQ+ + A +++ + + L Q Q +
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQ---AALRQK-QAADAEMEKHKKFAEQTLRQKAQ-V 2184
Query: 223 REQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQ-- 280
++L + E+ + Q+ + D ++Q L+A + R Q
Sbjct: 2185 EQELTTLRLQLEETDHQK-----------------NLLDEELQRLKAEATEAARQRSQVE 2227
Query: 281 ---HRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+RV E+L L ++ AE+R L + ++ Q QE + ++
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Score = 49.3 bits (116), Expect = 1e-05
Identities = 81/367 (22%), Positives = 139/367 (37%), Gaps = 65/367 (17%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+ ++ + E + Q E LA A Q +E E + + + A+ A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ-------RQRKEL---- 129
+ S S++ + A R + EA AL E+ ++ Q RQR E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 130 -----------RIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQ------- 170
R++ E E+AL E ER+ E+E R LE+QAA +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 171 ----------------------RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
R R+Q E+E L ++ + L G++ S
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 209 EDQRERLLQGVQEMREQLDVA---QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
ED Q E Q +A +R + E + + + +EE R + +V+
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR---KAALEEVE 2012
Query: 266 ELQASMAQHRR---GALQHRIRVLEEQLKSLGEQMAAESR----GLSRKKEEALQALSQE 318
L+A + + RR A Q R L+ ++ +++ AE + + +K++E Q L QE
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 319 RSRLLEL 325
+S L +L
Sbjct: 2073 QSVLDQL 2079
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/349 (23%), Positives = 135/349 (38%), Gaps = 32/349 (9%)
Query: 158 LRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ 217
+ E L + E+ QQR +E+ RL++ LE RQ L +A Q +Q E + + L Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQ 1395
Query: 218 GVQE---MREQLDV-AQRAYEDL--EFQQLERES--------RQEEEDRDSPGPQVPDPK 263
+QE RE+ V AQ+ + E QQL + S RQ E S + +
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 264 VQELQASMAQHRRGALQHRIRVLE---EQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
V LQ + +RG + ++ L E+ ++ Q E+ L R+ ++ Q Q
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 321 RLLELNCLQGTPGGDFSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVH 379
L + + AL +L L ++ +R+L + A + S
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 380 SSLQGSIG--LQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLY 437
+ LQ ++T L R E R E E A A + R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLR-------EEAERRAQQQAEAERAREEAE 1628
Query: 438 QLLNCGRGNSCGAIH----PDIAHMERLLQQAMAERERLLKAREGTRRG 482
+ L + + A+ + ++ L QA AE+++ RE RRG
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRG-ELAGERVAARRE-EEQLREL---LEQQAASEQ 170
E+R+ E QR + R+ EVE AL + +LA A+ + E + +EL ++++ +
Sbjct: 1347 EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405
Query: 171 RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ 230
+Q++R + +E +L + +A+ + E R R+ + ++ +R QL+ +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 231 RAYEDLE---------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQH 281
R E ++ E + RQ +E+ + QV D ++ QA +
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--------- 1516
Query: 282 RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
L ++K+ E + R L +E LQA ER
Sbjct: 1517 ----LASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Score = 46.6 bits (109), Expect = 7e-05
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 156 EQLRELLEQQAASEQRGRQ-QREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
E LR + E E+R + QR +E+ RL++ LE RQ L +A Q +Q E + +
Sbjct: 1339 ETLRRMEE-----EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1392
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDSPGPQVPDPKVQELQASMAQ 273
L Q +QE +V +R ++ QQ +R ++E ++ R S ++ + + QA A+
Sbjct: 1393 LQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKARQAEAAE 1444
Query: 274 HRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
R ++ IRV+ QL++ Q L + A +A +Q+R
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 41/329 (12%)
Query: 31 ESREQEASEVLAEPSS-----RGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA---- 81
+ +EQE + L + S RG AE E E + ++ R+A ++ + A
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 82 ------------ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL 129
A A +E + AARR Q +Q + A + K + + L
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 130 RIEMEVEVALLRGELAGERVAARRE--EEQLRELLEQQAASEQRGRQQREQEQRRLSQER 187
R + +VE L L E ++ +E+L+ L + +A R R Q E+E + +
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAARQRSQVEEELFSVRVQM 2205
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL--DVAQRAYEDLEFQQLERES 245
+ L L+ R+ L + +D +R LQ E +Q+ + A+ + E +L + +
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 246 RQEEEDRDSPGPQVPDPKVQELQ--------ASMAQHRRGALQHRIRVLEEQLKSLGEQM 297
++ + + ++ K+Q +Q A + Q ++ Q + R L+E + + +Q+
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 298 AAESRGLSRKKEEALQALSQERSRLLELN 326
A E++G R L ER R LE++
Sbjct: 2326 AEETQGFQR-------TLEAERQRQLEMS 2347
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 35/285 (12%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +EQ A + LAE + +AE + E S+ A A A +
Sbjct: 2315 QEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQR--------KELRIEMEVEVALLR 141
R+ +L +L +V L++ E+QRQ+ +E E+E E L+
Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQ--TLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431
Query: 142 GE-----LAGERVAARREEEQLREL--LEQQAASEQRGRQQREQEQRRLSQERDRLEGL- 193
E L E + ++E+ L+E L+Q SE+ QRE R + QE+ +LE L
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE---RFIEQEKAKLEQLF 2488
Query: 194 ------RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY--EDLEFQQLERES 245
Q+LR+ Q + Q E +R+RL+ ++E R + A+ + E QQLE++
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 246 RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
RQ+EE ++ ++LQ QH R AL H V Q+
Sbjct: 2549 RQQEELLAEENQRLR----EQLQLLEEQH-RAALAHSEEVTASQV 2588
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 45/259 (17%)
Query: 50 AEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEAL 109
AEQQ + EV EG +R + EA +A+ PA+ + R + +L+ Q+ +L
Sbjct: 992 AEQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE--QVRSL 1048
Query: 110 TRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL-------- 161
+ + L + + L ++RG E V R EEQL+E
Sbjct: 1049 SAIYLEKLKTISL----------------VIRGTQGAEEVL-RAHEEQLKEAQAVPATLP 1091
Query: 162 -LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQPEDQRER--- 214
LE AS ++ R Q E +Q RD L G ++ RL++ G+ D + E RER
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK-----VQELQA 269
LL+ Q + Q DV QR E +QL R+ R E D G + D + +Q +
Sbjct: 1152 LLERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1206
Query: 270 SMAQHRRGALQHRIRVLEE 288
+ +Q R L+ +LEE
Sbjct: 1207 ADSQAVREQLRQEQALLEE 1225
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/293 (22%), Positives = 133/293 (45%), Gaps = 17/293 (5%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIA--MAATPPAST 88
E + E E LAE + E+Q + E + ++ R+A E + + A+
Sbjct: 1320 EQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 89 SSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA-GE 147
+++ R LQ QL + + + + +R LRIE E+ V L+ E +
Sbjct: 1378 DAQQQKRSIQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 148 RVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQ 207
R A E + LR E+ A +++ +++ E+ +R++ E R L ++ + +++
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAE 1494
Query: 208 PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL 267
+++R LQ ++E+R Q + A+R +Q E E ++ + + + ++Q
Sbjct: 1495 AAREKQRALQALEELRLQAEEAER-----RLRQAEVERARQVQVALETAQRSAEAELQSK 1549
Query: 268 QASMAQHRRGALQHRIR---VLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+AS A+ + L+ ++ V QL+ E+ A + R +EEA + L +
Sbjct: 1550 RASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 22/307 (7%)
Query: 34 EQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREG 93
E A L E + R A+QQAE E E + E R +A + + +
Sbjct: 1567 EHVAVAQLREEAERR-AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625
Query: 94 VRGAARRLQGQ-QLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE----R 148
+ A + + + + EA R EQ V++ + +EL + ++ + LA E R
Sbjct: 1626 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1685
Query: 149 VAARREE-EQLRELLEQQAASEQR----GRQQREQEQRRLSQERDRLEGLRQRLRKAQGQ 203
+ A E+ EQ R+LLE++ A QR Q+R++ + L++ R +E L +A+ +
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
S E ++RL RE + A R E + +R+ +E+ R +
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERV 1802
Query: 264 VQELQASMAQHRRGALQHRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ E A++ + R + I + E E+L+ L E A + R R +E+A Q +
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---RLEEQAAQHKADI 1859
Query: 319 RSRLLEL 325
RL +L
Sbjct: 1860 EERLAQL 1866
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 35/261 (13%)
Query: 97 AARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
AAR Q + + + AL E+ +KE +Q ++ R++ E E+ + ELA E+ +E+
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2317
Query: 156 -EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
EQ+ + L ++ QR + Q Q +S E +RL+ + +AQ + + + R++
Sbjct: 2318 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2377
Query: 215 --------------------LLQGVQEMREQLD-VAQRAYEDLEFQQLERESRQEE---- 249
L+Q ++ R+Q D A+R E + + E+E Q+E
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 250 ----EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ---LKSLGEQMAAESR 302
E+ + + + Q LQ S + LQ R R +E++ L+ L + A+++
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 303 GLSRKKEEALQALSQERSRLL 323
L +++ Q + QER RL+
Sbjct: 2497 QLREEQQRQQQQMEQERQRLV 2517
Score = 56.6 bits (135), Expect = 7e-08
Identities = 79/296 (26%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ---GQQLE 107
E A++ + E E + EAT + A +E + ARRLQ Q +
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEAT---RLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323
Query: 108 ALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG-ERVAARREEEQLRELLEQQA 166
L QR E +RQR ++EM E L+ +A R AR EE+ R + +
Sbjct: 2324 QLAEETQGFQRTLEAERQR---QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 167 ASEQRGRQQREQEQR-----RLSQERDRLEGLRQRLRKAQGQLDSQPE--DQRERLLQGV 219
E+ R + +++ L +R + + +RLR+A +L+ + E Q +LLQ
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 220 QEMREQLDVAQRAYEDLEFQQ---------LERESRQEEEDRDSPGP-QVPDPKVQELQA 269
E + + Q E QQ L+RE E+E Q K Q+L+
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ ++ Q R R++ ++ Q AE G+ RK+EE LQ L Q+R + EL
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEE-LQQLEQQRRQQEEL 2554
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 43/322 (13%)
Query: 20 DVEVQPQGHPEESREQ-EASEVL---AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEAT 75
+ VQ + +SR Q E +E L AE ++ A+ QA E++ + + E++R A
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122
Query: 76 PPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV--------KELQRQRK 127
+ A + R + Q + LT + L + +ELQR +
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182
Query: 128 E-----------------LRIEMEVEVALLRGELAGE-RVAARREEEQLRELLEQQAASE 169
E +R++ME E++ L+ + E R R+++ + L+++A
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQME-ELSKLKARIEAENRALILRDKDNTQRFLQEEAEK- 2240
Query: 170 QRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVA 229
+Q +E RLS LRQ + Q + E + +Q VQE A
Sbjct: 2241 ---MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2297
Query: 230 QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ 289
+ + E Q ++R+ +ED++ Q+ + + Q Q ++ R+ L+ + +
Sbjct: 2298 ELLQQQKELAQ--EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLE-----MSAE 2349
Query: 290 LKSLGEQMAAESRGLSRKKEEA 311
+ L ++A SR +R +E+A
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDA 2371
Score = 50.1 bits (118), Expect = 6e-06
Identities = 69/347 (19%), Positives = 135/347 (38%), Gaps = 50/347 (14%)
Query: 4 RSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
RS+ E+ E + Q Q EE R + +E + S AE++A +
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL--AAEEEAARQRKAALE 1977
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ 123
E + E + A ++ + A +RLQ ++ V EQ +++
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 124 RQRK---------------------ELRIEMEVEVALLRGELAGERVAARREEEQLRELL 162
+Q + E R++ E E A R ++ + EEQ +
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 163 EQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM 222
+ QAA+E+ ++ ++ RR E+ LRQ+ + A +++ + + L Q Q +
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQ---AALRQK-QAADAEMEKHKKFAEQTLRQKAQ-V 2152
Query: 223 REQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQ-- 280
++L + E+ + Q+ + D ++Q L+A + R Q
Sbjct: 2153 EQELTTLRLQLEETDHQK-----------------NLLDEELQRLKAEATEAARQRSQVE 2195
Query: 281 ---HRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+RV E+L L ++ AE+R L + ++ Q QE + ++
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Score = 49.3 bits (116), Expect = 1e-05
Identities = 81/367 (22%), Positives = 139/367 (37%), Gaps = 65/367 (17%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+ ++ + E + Q E LA A Q +E E + + + A+ A
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ-------RQRKEL---- 129
+ S S++ + A R + EA AL E+ ++ Q RQR E
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803
Query: 130 -----------RIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQ------- 170
R++ E E+AL E ER+ E+E R LE+QAA +
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 171 ----------------------RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
R R+Q E+E L ++ + L G++ S
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923
Query: 209 EDQRERLLQGVQEMREQLDVA---QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
ED Q E Q +A +R + E + + + +EE R + +V+
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR---KAALEEVE 1980
Query: 266 ELQASMAQHRR---GALQHRIRVLEEQLKSLGEQMAAESR----GLSRKKEEALQALSQE 318
L+A + + RR A Q R L+ ++ +++ AE + + +K++E Q L QE
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040
Query: 319 RSRLLEL 325
+S L +L
Sbjct: 2041 QSVLDQL 2047
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/349 (23%), Positives = 135/349 (38%), Gaps = 32/349 (9%)
Query: 158 LRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ 217
+ E L + E+ QQR +E+ RL++ LE RQ L +A Q +Q E + + L Q
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQ 1363
Query: 218 GVQE---MREQLDV-AQRAYEDL--EFQQLERES--------RQEEEDRDSPGPQVPDPK 263
+QE RE+ V AQ+ + E QQL + S RQ E S + +
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 264 VQELQASMAQHRRGALQHRIRVLE---EQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
V LQ + +RG + ++ L E+ ++ Q E+ L R+ ++ Q Q
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 321 RLLELNCLQGTPGGDFSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVH 379
L + + AL +L L ++ +R+L + A + S
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 380 SSLQGSIG--LQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLY 437
+ LQ ++T L R E R E E A A + R
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLR-------EEAERRAQQQAEAERAREEAE 1596
Query: 438 QLLNCGRGNSCGAIH----PDIAHMERLLQQAMAERERLLKAREGTRRG 482
+ L + + A+ + ++ L QA AE+++ RE RRG
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRG-ELAGERVAARRE-EEQLREL---LEQQAASEQ 170
E+R+ E QR + R+ EVE AL + +LA A+ + E + +EL ++++ +
Sbjct: 1315 EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1373
Query: 171 RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ 230
+Q++R + +E +L + +A+ + E R R+ + ++ +R QL+ +
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1433
Query: 231 RAYEDLE---------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQH 281
R E ++ E + RQ +E+ + QV D ++ QA +
Sbjct: 1434 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--------- 1484
Query: 282 RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
L ++K+ E + R L +E LQA ER
Sbjct: 1485 ----LASRVKAEAEAAREKQRALQALEELRLQAEEAER 1518
Score = 46.6 bits (109), Expect = 7e-05
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 156 EQLRELLEQQAASEQRGRQ-QREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
E LR + E E+R + QR +E+ RL++ LE RQ L +A Q +Q E + +
Sbjct: 1307 ETLRRMEE-----EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1360
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDSPGPQVPDPKVQELQASMAQ 273
L Q +QE +V +R ++ QQ +R ++E ++ R S ++ + + QA A+
Sbjct: 1361 LQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKARQAEAAE 1412
Query: 274 HRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
R ++ IRV+ QL++ Q L + A +A +Q+R
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/329 (22%), Positives = 139/329 (42%), Gaps = 41/329 (12%)
Query: 31 ESREQEASEVLAEPSS-----RGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMA---- 81
+ +EQE + L + S RG AE E E + ++ R+A ++ + A
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 82 ------------ATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKEL 129
A A +E + AARR Q +Q + A + K + + L
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 130 RIEMEVEVALLRGELAGERVAARRE--EEQLRELLEQQAASEQRGRQQREQEQRRLSQER 187
R + +VE L L E ++ +E+L+ L + +A R R Q E+E + +
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAARQRSQVEEELFSVRVQM 2374
Query: 188 DRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQL--DVAQRAYEDLEFQQLERES 245
+ L L+ R+ L + +D +R LQ E +Q+ + A+ + E +L + +
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 246 RQEEEDRDSPGPQVPDPKVQELQ--------ASMAQHRRGALQHRIRVLEEQLKSLGEQM 297
++ + + ++ K+Q +Q A + Q ++ Q + R L+E + + +Q+
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 298 AAESRGLSRKKEEALQALSQERSRLLELN 326
A E++G R L ER R LE++
Sbjct: 2495 AEETQGFQR-------TLEAERQRQLEMS 2516
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 35/285 (12%)
Query: 30 EESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTS 89
+E +EQ A + LAE + +AE + E S+ A A A +
Sbjct: 2484 QEDKEQMAQQ-LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 90 SREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQR--------KELRIEMEVEVALLR 141
R+ +L +L +V L++ E+QRQ+ +E E+E E L+
Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQ--TLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600
Query: 142 GE-----LAGERVAARREEEQLREL--LEQQAASEQRGRQQREQEQRRLSQERDRLEGL- 193
E L E + ++E+ L+E L+Q SE+ QRE R + QE+ +LE L
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE---RFIEQEKAKLEQLF 2657
Query: 194 ------RQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAY--EDLEFQQLERES 245
Q+LR+ Q + Q E +R+RL+ ++E R + A+ + E QQLE++
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 246 RQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQL 290
RQ+EE ++ ++LQ QH R AL H V Q+
Sbjct: 2718 RQQEELLAEENQRLR----EQLQLLEEQH-RAALAHSEEVTASQV 2757
Score = 62.0 bits (149), Expect = 2e-09
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 45/259 (17%)
Query: 50 AEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEAL 109
AEQQ + EV EG +R + EA +A+ PA+ + R + +L+ Q+ +L
Sbjct: 1161 AEQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE--QVRSL 1217
Query: 110 TRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL-------- 161
+ + L + + L ++RG E V R EEQL+E
Sbjct: 1218 SAIYLEKLKTISL----------------VIRGTQGAEEVL-RAHEEQLKEAQAVPATLP 1260
Query: 162 -LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQ---RLRKAQGQLDSQPEDQRER--- 214
LE AS ++ R Q E +Q RD L G ++ RL++ G+ D + E RER
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK-----VQELQA 269
LL+ Q + Q DV QR E +QL R+ R E D G + D + +Q +
Sbjct: 1321 LLERWQAVLAQTDVRQR-----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1375
Query: 270 SMAQHRRGALQHRIRVLEE 288
+ +Q R L+ +LEE
Sbjct: 1376 ADSQAVREQLRQEQALLEE 1394
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/293 (22%), Positives = 133/293 (45%), Gaps = 17/293 (5%)
Query: 31 ESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIA--MAATPPAST 88
E + E E LAE + E+Q + E + ++ R+A E + + A+
Sbjct: 1489 EQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 89 SSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELA-GE 147
+++ R LQ QL + + + + +R LRIE E+ V L+ E +
Sbjct: 1547 DAQQQKRSIQEELQ--QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 148 RVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQ 207
R A E + LR E+ A +++ +++ E+ +R++ E R L ++ + +++
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL-ASRVKAEAE 1663
Query: 208 PEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQEL 267
+++R LQ ++E+R Q + A+R +Q E E ++ + + + ++Q
Sbjct: 1664 AAREKQRALQALEELRLQAEEAER-----RLRQAEVERARQVQVALETAQRSAEAELQSK 1718
Query: 268 QASMAQHRRGALQHRIR---VLEEQLKSLGEQMAAESRGLSRKKEEALQALSQ 317
+AS A+ + L+ ++ V QL+ E+ A + R +EEA + L +
Sbjct: 1719 RASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 22/307 (7%)
Query: 34 EQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREG 93
E A L E + R A+QQAE E E + E R +A + + +
Sbjct: 1736 EHVAVAQLREEAERR-AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794
Query: 94 VRGAARRLQGQ-QLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGE----R 148
+ A + + + + EA R EQ V++ + +EL + ++ + LA E R
Sbjct: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854
Query: 149 VAARREE-EQLRELLEQQAASEQR----GRQQREQEQRRLSQERDRLEGLRQRLRKAQGQ 203
+ A E+ EQ R+LLE++ A QR Q+R++ + L++ R +E L +A+ +
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914
Query: 204 LDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPK 263
S E ++RL RE + A R E + +R+ +E+ R +
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERV 1971
Query: 264 VQELQASMAQHRRGALQHRIRVLE-----EQLKSLGEQMAAESRGLSRKKEEALQALSQE 318
+ E A++ + R + I + E E+L+ L E A + R R +E+A Q +
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---RLEEQAAQHKADI 2028
Query: 319 RSRLLEL 325
RL +L
Sbjct: 2029 EERLAQL 2035
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 35/261 (13%)
Query: 97 AARRLQGQQLEALTRVALMEQRVKE-LQRQRKELRIEMEVEVALLRGELAGERVAARREE 155
AAR Q + + + AL E+ +KE +Q ++ R++ E E+ + ELA E+ +E+
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2486
Query: 156 -EQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
EQ+ + L ++ QR + Q Q +S E +RL+ + +AQ + + + R++
Sbjct: 2487 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2546
Query: 215 --------------------LLQGVQEMREQLD-VAQRAYEDLEFQQLERESRQEE---- 249
L+Q ++ R+Q D A+R E + + E+E Q+E
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 250 ----EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ---LKSLGEQMAAESR 302
E+ + + + Q LQ S + LQ R R +E++ L+ L + A+++
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 303 GLSRKKEEALQALSQERSRLL 323
L +++ Q + QER RL+
Sbjct: 2666 QLREEQQRQQQQMEQERQRLV 2686
Score = 56.6 bits (135), Expect = 7e-08
Identities = 79/296 (26%), Positives = 126/296 (42%), Gaps = 29/296 (9%)
Query: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQ---GQQLE 107
E A++ + E E + EAT + A +E + ARRLQ Q +
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEAT---RLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492
Query: 108 ALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAG-ERVAARREEEQLRELLEQQA 166
L QR E +RQR ++EM E L+ +A R AR EE+ R + +
Sbjct: 2493 QLAEETQGFQRTLEAERQR---QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 167 ASEQRGRQQREQEQR-----RLSQERDRLEGLRQRLRKAQGQLDSQPE--DQRERLLQGV 219
E+ R + +++ L +R + + +RLR+A +L+ + E Q +LLQ
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 220 QEMREQLDVAQRAYEDLEFQQ---------LERESRQEEEDRDSPGP-QVPDPKVQELQA 269
E + + Q E QQ L+RE E+E Q K Q+L+
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 270 SMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLEL 325
+ ++ Q R R++ ++ Q AE G+ RK+EE LQ L Q+R + EL
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEE-LQQLEQQRRQQEEL 2723
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 43/322 (13%)
Query: 20 DVEVQPQGHPEESREQ-EASEVL---AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEAT 75
+ VQ + +SR Q E +E L AE ++ A+ QA E++ + + E++R A
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291
Query: 76 PPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRV--------KELQRQRK 127
+ A + R + Q + LT + L + +ELQR +
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351
Query: 128 E-----------------LRIEMEVEVALLRGELAGE-RVAARREEEQLRELLEQQAASE 169
E +R++ME E++ L+ + E R R+++ + L+++A
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQME-ELSKLKARIEAENRALILRDKDNTQRFLQEEAEK- 2409
Query: 170 QRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVA 229
+Q +E RLS LRQ + Q + E + +Q VQE A
Sbjct: 2410 ---MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2466
Query: 230 QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQ 289
+ + E Q ++R+ +ED++ Q+ + + Q Q ++ R+ L+ + +
Sbjct: 2467 ELLQQQKELAQ--EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLE-----MSAE 2518
Query: 290 LKSLGEQMAAESRGLSRKKEEA 311
+ L ++A SR +R +E+A
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDA 2540
Score = 50.1 bits (118), Expect = 6e-06
Identities = 69/347 (19%), Positives = 135/347 (38%), Gaps = 50/347 (14%)
Query: 4 RSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGS 63
RS+ E+ E + Q Q EE R + +E + S AE++A +
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL--AAEEEAARQRKAALE 2146
Query: 64 STESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ 123
E + E + A ++ + A +RLQ ++ V EQ +++
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 124 RQRK---------------------ELRIEMEVEVALLRGELAGERVAARREEEQLRELL 162
+Q + E R++ E E A R ++ + EEQ +
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 163 EQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEM 222
+ QAA+E+ ++ ++ RR E+ LRQ+ + A +++ + + L Q Q +
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQ---AALRQK-QAADAEMEKHKKFAEQTLRQKAQ-V 2321
Query: 223 REQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQ-- 280
++L + E+ + Q+ + D ++Q L+A + R Q
Sbjct: 2322 EQELTTLRLQLEETDHQK-----------------NLLDEELQRLKAEATEAARQRSQVE 2364
Query: 281 ---HRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLE 324
+RV E+L L ++ AE+R L + ++ Q QE + ++
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Score = 49.3 bits (116), Expect = 1e-05
Identities = 81/367 (22%), Positives = 139/367 (37%), Gaps = 65/367 (17%)
Query: 21 VEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAM 80
+ ++ + E + Q E LA A Q +E E + + + A+ A
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912
Query: 81 AATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQ-------RQRKEL---- 129
+ S S++ + A R + EA AL E+ ++ Q RQR E
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972
Query: 130 -----------RIEMEVEVALLRGELAGERVAARREEEQL-RELLEQQAASEQ------- 170
R++ E E+AL E ER+ E+E R LE+QAA +
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 171 ----------------------RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQP 208
R R+Q E+E L ++ + L G++ S
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092
Query: 209 EDQRERLLQGVQEMREQLDVA---QRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQ 265
ED Q E Q +A +R + E + + + +EE R + +V+
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR---KAALEEVE 2149
Query: 266 ELQASMAQHRR---GALQHRIRVLEEQLKSLGEQMAAESR----GLSRKKEEALQALSQE 318
L+A + + RR A Q R L+ ++ +++ AE + + +K++E Q L QE
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209
Query: 319 RSRLLEL 325
+S L +L
Sbjct: 2210 QSVLDQL 2216
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/349 (23%), Positives = 135/349 (38%), Gaps = 32/349 (9%)
Query: 158 LRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQ 217
+ E L + E+ QQR +E+ RL++ LE RQ L +A Q +Q E + + L Q
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQ 1532
Query: 218 GVQE---MREQLDV-AQRAYEDL--EFQQLERES--------RQEEEDRDSPGPQVPDPK 263
+QE RE+ V AQ+ + E QQL + S RQ E S + +
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 264 VQELQASMAQHRRGALQHRIRVLE---EQLKSLGEQMAAESRGLSRKKEEALQALSQERS 320
V LQ + +RG + ++ L E+ ++ Q E+ L R+ ++ Q Q
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 321 RLLELNCLQGTPGGDFSEPNPALTKL-LFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVH 379
L + + AL +L L ++ +R+L + A + S
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 380 SSLQGSIG--LQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLY 437
+ LQ ++T L R E R E E A A + R
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLR-------EEAERRAQQQAEAERAREEAE 1765
Query: 438 QLLNCGRGNSCGAIH----PDIAHMERLLQQAMAERERLLKAREGTRRG 482
+ L + + A+ + ++ L QA AE+++ RE RRG
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 28/218 (12%)
Query: 116 EQRVKELQRQRKELRIEMEVEVALLRG-ELAGERVAARRE-EEQLREL---LEQQAASEQ 170
E+R+ E QR + R+ EVE AL + +LA A+ + E + +EL ++++ +
Sbjct: 1484 EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542
Query: 171 RGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQ 230
+Q++R + +E +L + +A+ + E R R+ + ++ +R QL+ +
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 231 RAYEDLE---------FQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQH 281
R E ++ E + RQ +E+ + QV D ++ QA +
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--------- 1653
Query: 282 RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
L ++K+ E + R L +E LQA ER
Sbjct: 1654 ----LASRVKAEAEAAREKQRALQALEELRLQAEEAER 1687
Score = 46.6 bits (109), Expect = 7e-05
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 156 EQLRELLEQQAASEQRGRQ-QREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRER 214
E LR + E E+R + QR +E+ RL++ LE RQ L +A Q +Q E + +
Sbjct: 1476 ETLRRMEE-----EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1529
Query: 215 LLQGVQEMREQLDVAQRAYEDLEFQQLERESRQE-EEDRDSPGPQVPDPKVQELQASMAQ 273
L Q +QE +V +R ++ QQ +R ++E ++ R S ++ + + QA A+
Sbjct: 1530 LQQRMQE-----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKARQAEAAE 1581
Query: 274 HRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQER 319
R ++ IRV+ QL++ Q L + A +A +Q+R
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,474,433
Number of Sequences: 37866
Number of extensions: 1536100
Number of successful extensions: 25424
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 417
Number of HSP's successfully gapped in prelim test: 1246
Number of HSP's that attempted gapping in prelim test: 12541
Number of HSP's gapped (non-prelim): 6843
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.