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Search of human proteins with 156938287
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156938287 SH2 domain containing 5 isoform 1 [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156938287 SH2 domain containing 5 isoform 1 [Homo sapiens] 880 0.0
gi|157041224 SH2 domain containing 5 isoform 2 [Homo sapiens] 709 0.0
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 45 2e-04
gi|66529407 tensin [Homo sapiens] 39 0.012
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 38 0.020
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 37 0.034
gi|50511947 cajalin 2 isoform b [Homo sapiens] 37 0.044
gi|50511945 cajalin 2 isoform a [Homo sapiens] 36 0.058
gi|10047134 cajalin 2 isoform c [Homo sapiens] 36 0.058
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 36 0.058
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 33 0.37
gi|38787970 tensin like C1 domain containing phosphatase isoform... 33 0.37
gi|38787957 tensin like C1 domain containing phosphatase isoform... 33 0.37
gi|38787941 tensin like C1 domain containing phosphatase isoform... 33 0.37
gi|31377557 hypothetical protein LOC131583 [Homo sapiens] 33 0.37
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 33 0.49
gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] 33 0.64
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 32 0.83
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 31 1.9
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 31 1.9
gi|65288071 tensin 3 [Homo sapiens] 31 1.9
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 31 1.9
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 31 1.9
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 31 1.9
gi|54792745 SH2 domain containing 1B [Homo sapiens] 31 1.9
gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens] 31 1.9
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 31 2.4
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 31 2.4
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 31 2.4
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 31 2.4
>gi|156938287 SH2 domain containing 5 isoform 1 [Homo sapiens]
Length = 423
Score = 880 bits (2273), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPR 60
MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPR
Sbjct: 1 MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPR 60
Query: 61 RRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFC 120
RRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFC
Sbjct: 61 RRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFC 120
Query: 121 HLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVR 180
HLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVR
Sbjct: 121 HLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVR 180
Query: 181 EPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAI 240
EPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAI
Sbjct: 181 EPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAI 240
Query: 241 RSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAG 300
RSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAG
Sbjct: 241 RSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAG 300
Query: 301 ISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPA 360
ISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPA
Sbjct: 301 ISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPA 360
Query: 361 EFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQ 420
EFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQ
Sbjct: 361 EFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQ 420
Query: 421 GLG 423
GLG
Sbjct: 421 GLG 423
>gi|157041224 SH2 domain containing 5 isoform 2 [Homo sapiens]
Length = 339
Score = 709 bits (1829), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 85 MAHALRRILYSTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQL 144
MAHALRRILYSTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQL
Sbjct: 1 MAHALRRILYSTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQL 60
Query: 145 AYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAE 204
AYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAE
Sbjct: 61 AYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAE 120
Query: 205 GLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAR 264
GLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAR
Sbjct: 121 GLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAR 180
Query: 265 EAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPEL 324
EAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPEL
Sbjct: 181 EAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPEL 240
Query: 325 GASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLD 384
GASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLD
Sbjct: 241 GASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLD 300
Query: 385 MGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQGLG 423
MGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQGLG
Sbjct: 301 MGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQGLG 339
>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
1 [Homo sapiens]
Length = 1134
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/182 (26%), Positives = 83/182 (45%), Gaps = 17/182 (9%)
Query: 28 AQYVGSFPVDDL----DTQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVL 83
A Y+GS + DL TQ++ +++ +K P +IL + +G+K + +
Sbjct: 944 ANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIP---TIILSITYKGVKFIDASNKNV 1000
Query: 84 LMAHALRRILYSTWCPAD-CQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSF 142
+ H +R I + P D C FA++ ++ ++ S +CH+F + L L ++F
Sbjct: 1001 IAEHEIRNISCAAQDPEDLCTFAYITKDLQT--SHHYCHVFSTVDVNLTYEIILTLGQAF 1058
Query: 143 QLAY--LLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVR----EPFGRDQLSQNVHALV 196
++AY LQ + RA KP+ VR EP DQ +Q+ HA V
Sbjct: 1059 EVAYQLALQAQKSRATGASAAEMIETKSSKPVPKPRVGVRKSALEPPDMDQDAQS-HASV 1117
Query: 197 SF 198
S+
Sbjct: 1118 SW 1119
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 38.5 bits (88), Expect = 0.012
Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 18/127 (14%)
Query: 292 TENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQC-----------GV 340
T W ISR A+ALL+ GAF++ G + L+++ G
Sbjct: 1459 TSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGD 1518
Query: 341 VPHQVFRNHLGR-----YCLEHLPAE--FPSLEALVENHAVTERSLFCPLDMGRLNPTYE 393
+ H++ R+ L L+ P E F SL ALV H++ +L C L + +PT E
Sbjct: 1519 MTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDE 1578
Query: 394 EQDCGPP 400
+D P
Sbjct: 1579 SKDSSGP 1585
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 37.7 bits (86), Expect = 0.020
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 3/99 (3%)
Query: 287 SEGSLTENIWAFAGISRPCALALLRR--DVLGAFLLWPELGASGQWCLSVRTQCGVVPHQ 344
S +L++ W F+G+SR A LL + GAFL+ P + G + LSVR Q V ++
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 345 VFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
V G L+ FP LE L+ + + + PL
Sbjct: 171 VSMAADGSLYLQK-GRLFPGLEELLTYYKANWKLIQNPL 208
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 37.0 bits (84), Expect = 0.034
Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 296 WAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCL 355
W G+SR A LL +G F++ + G + +SVR + V +V R++ G Y L
Sbjct: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 356 EHLPAEFPSLEALVE 370
+FPSL LV+
Sbjct: 118 --WTEKFPSLNKLVD 130
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 36.6 bits (83), Expect = 0.044
Identities = 40/177 (22%), Positives = 70/177 (39%), Gaps = 15/177 (8%)
Query: 28 AQYVGSFPVDDLDTQESVWLV--------QQQLWALKDCPRRRAVILKFSLQGLKIYSGE 79
A Y+GS + +L ES Q+ +K P +IL S +G+K
Sbjct: 314 AFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVP---TIILSVSYKGVKFIDAT 370
Query: 80 GEVLLMAHALRRILYSTWCPADCQ-FAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLL 138
+ ++ H +R I + P D FA++ ++ +S + +CH+F + L L
Sbjct: 371 NKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKS--NHHYCHVFTAFDVNLAYEIILTL 428
Query: 139 CRSFQLAY-LLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHA 194
++F++AY L + P P KP+ +R+ D Q A
Sbjct: 429 GQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLA 485
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 36.2 bits (82), Expect = 0.058
Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 14/130 (10%)
Query: 28 AQYVGSFPVDDLDTQESVWLV--------QQQLWALKDCPRRRAVILKFSLQGLKIYSGE 79
A Y+GS + +L ES Q+ +K P +IL S +G+K
Sbjct: 1064 AFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVP---TIILSVSYKGVKFIDAT 1120
Query: 80 GEVLLMAHALRRILYSTWCPADCQ-FAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLL 138
+ ++ H +R I + P D FA++ ++ +S + +CH+F + L L
Sbjct: 1121 NKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKS--NHHYCHVFTAFDVNLAYEIILTL 1178
Query: 139 CRSFQLAYLL 148
++F++AY L
Sbjct: 1179 GQAFEVAYQL 1188
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 36.2 bits (82), Expect = 0.058
Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 14/130 (10%)
Query: 28 AQYVGSFPVDDLDTQESVWLV--------QQQLWALKDCPRRRAVILKFSLQGLKIYSGE 79
A Y+GS + +L ES Q+ +K P +IL S +G+K
Sbjct: 230 AFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVP---TIILSVSYKGVKFIDAT 286
Query: 80 GEVLLMAHALRRILYSTWCPADCQ-FAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLL 138
+ ++ H +R I + P D FA++ ++ +S + +CH+F + L L
Sbjct: 287 NKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKS--NHHYCHVFTAFDVNLAYEIILTL 344
Query: 139 CRSFQLAYLL 148
++F++AY L
Sbjct: 345 GQAFEVAYQL 354
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 36.2 bits (82), Expect = 0.058
Identities = 24/73 (32%), Positives = 34/73 (46%), Gaps = 9/73 (12%)
Query: 354 CLEHLPAEFPSLEALVENHAVT---ERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPL 410
CL+ L E SL+ +E HA+T S + PL+ +P GP G P R
Sbjct: 1431 CLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQR----- 1485
Query: 411 SHAKSEAELQGLG 423
H++S A +G G
Sbjct: 1486 -HSQSRASKEGPG 1497
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 33.5 bits (75), Expect = 0.37
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 296 WAFAGISRPCALALL---RRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGR 352
W F I R A +L R D GAFL+ A G + LSV+ V +V R+ G+
Sbjct: 60 WFFGKIPRAKAEEMLSKQRHD--GAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117
Query: 353 YCLEHLPAEFPSLEALVENHAVTERS 378
Y L +F SL LV+ H T S
Sbjct: 118 YFL--WVVKFNSLNELVDYHRSTSVS 141
>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
[Homo sapiens]
Length = 1285
Score = 33.5 bits (75), Expect = 0.37
Identities = 32/125 (25%), Positives = 50/125 (40%), Gaps = 16/125 (12%)
Query: 292 TENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLG 351
T W +SR A+ALL+ GAFL+ G + L+++ Q ++
Sbjct: 1012 TSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPV 1071
Query: 352 RYCLEHL--------------PAE--FPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQ 395
+ H P+E F SL ALV H+++ SL C L + +P E
Sbjct: 1072 EQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETP 1131
Query: 396 DCGPP 400
+ P
Sbjct: 1132 EAPVP 1136
>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
[Homo sapiens]
Length = 1409
Score = 33.5 bits (75), Expect = 0.37
Identities = 32/125 (25%), Positives = 50/125 (40%), Gaps = 16/125 (12%)
Query: 292 TENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLG 351
T W +SR A+ALL+ GAFL+ G + L+++ Q ++
Sbjct: 1136 TSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPV 1195
Query: 352 RYCLEHL--------------PAE--FPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQ 395
+ H P+E F SL ALV H+++ SL C L + +P E
Sbjct: 1196 EQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETP 1255
Query: 396 DCGPP 400
+ P
Sbjct: 1256 EAPVP 1260
>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
[Homo sapiens]
Length = 1419
Score = 33.5 bits (75), Expect = 0.37
Identities = 32/125 (25%), Positives = 50/125 (40%), Gaps = 16/125 (12%)
Query: 292 TENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLG 351
T W +SR A+ALL+ GAFL+ G + L+++ Q ++
Sbjct: 1146 TSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPV 1205
Query: 352 RYCLEHL--------------PAE--FPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQ 395
+ H P+E F SL ALV H+++ SL C L + +P E
Sbjct: 1206 EQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETP 1265
Query: 396 DCGPP 400
+ P
Sbjct: 1266 EAPVP 1270
>gi|31377557 hypothetical protein LOC131583 [Homo sapiens]
Length = 423
Score = 33.5 bits (75), Expect = 0.37
Identities = 34/133 (25%), Positives = 61/133 (45%), Gaps = 12/133 (9%)
Query: 51 QLWALKDCPRRRAVI-LKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQ----FA 105
++W+ + R+ + L S QG+++ E L L + T+C AD + FA
Sbjct: 95 KIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFA 154
Query: 106 FMARNP-RSPASKLFCHLFVGSQPGEVQILHLLLCRS-----FQLAYLLQHPEERAQPEP 159
++ R+ + A L CH + S+P + Q + LLL ++ + L + + R Q +
Sbjct: 155 WVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQE 214
Query: 160 CPGPTGEVPLKPL 172
G +PL PL
Sbjct: 215 LVG-AHTIPLVPL 226
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 33.1 bits (74), Expect = 0.49
Identities = 31/94 (32%), Positives = 43/94 (45%), Gaps = 4/94 (4%)
Query: 281 HSCLVESEGSLTENIWAFAGISRPCALALLRRD--VLGAFLLWPELGASGQWCLSVRTQC 338
H+ L E E ++ W F ISR A+ L+ + GAFL+ S + LSVR
Sbjct: 64 HNYLAERE-TVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQ 122
Query: 339 GVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENH 372
V ++++R GR L F SL LV H
Sbjct: 123 AVRHYKIWRRAGGRLHLNE-AVSFLSLPELVNYH 155
>gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens]
Length = 261
Score = 32.7 bits (73), Expect = 0.64
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 10/96 (10%)
Query: 296 WAFAGISRPCA--LALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRY 353
W + G+SR A L LL + GAFL+ G + LSVR ++ H +
Sbjct: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRI--RHYRIH 151
Query: 354 CLEH------LPAEFPSLEALVENHAVTERSLFCPL 383
CL++ FPSL+ALV++++ + C L
Sbjct: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLL 187
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 32.3 bits (72), Expect = 0.83
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 296 WAFAGISRPCALALL-RRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYC 354
W ISR A +L +R+ LGAFL+ + G++ +SV V +V R G+Y
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119
Query: 355 LEHLPAEFPSLEALVENHAVT 375
L +F SL LV+ + T
Sbjct: 120 L--WEEKFNSLNELVDFYRTT 138
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 31.2 bits (69), Expect = 1.9
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 121 SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 181 DGKLYVSS-ESRFNTLAELVHHHSTVADGLITTL 213
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 31.2 bits (69), Expect = 1.9
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 140 SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 200 DGKLYVSS-ESRFNTLAELVHHHSTVADGLITTL 232
>gi|65288071 tensin 3 [Homo sapiens]
Length = 1445
Score = 31.2 bits (69), Expect = 1.9
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 24/146 (16%)
Query: 275 PRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSV 334
P PG +V+ T W A ISR A+A+L+ G+F++ G + L++
Sbjct: 1152 PDSPGDKLVIVKFVQD-TSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRGAYGLAM 1210
Query: 335 RTQCGVVPHQVFR---------NHLGRYCLEHLPAE------------FPSLEALVENHA 373
+ P V + N L R+ L + F SL ALV H+
Sbjct: 1211 KV--ATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQHS 1268
Query: 374 VTERSLFCPLDMGRLNPTYEEQDCGP 399
+T +L C L + +P E + P
Sbjct: 1269 ITPLALPCKLLIPERDPLEEIAESSP 1294
>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
Length = 1012
Score = 31.2 bits (69), Expect = 1.9
Identities = 13/33 (39%), Positives = 17/33 (51%)
Query: 150 HPEERAQPEPCPGPTGEVPLKPLSSSGGLVREP 182
HP+ P P P P+ PL+PL+ S G P
Sbjct: 253 HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAP 285
>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 31.2 bits (69), Expect = 1.9
Identities = 13/33 (39%), Positives = 17/33 (51%)
Query: 150 HPEERAQPEPCPGPTGEVPLKPLSSSGGLVREP 182
HP+ P P P P+ PL+PL+ S G P
Sbjct: 807 HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAP 839
>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 31.2 bits (69), Expect = 1.9
Identities = 13/33 (39%), Positives = 17/33 (51%)
Query: 150 HPEERAQPEPCPGPTGEVPLKPLSSSGGLVREP 182
HP+ P P P P+ PL+PL+ S G P
Sbjct: 807 HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAP 839
>gi|54792745 SH2 domain containing 1B [Homo sapiens]
Length = 132
Score = 31.2 bits (69), Expect = 1.9
Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 305 CALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAE--- 361
C LL+ V G FLL G CL V + V +++FR G Y ++
Sbjct: 15 CETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQ 74
Query: 362 -FPSLEALV 369
FPSL+ L+
Sbjct: 75 VFPSLKELI 83
>gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens]
Length = 210
Score = 31.2 bits (69), Expect = 1.9
Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 10/86 (11%)
Query: 296 WAFAGISRPCA--LALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRY 353
W + G+SR A L LL + GAFL+ G + LSVR ++ H +
Sbjct: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRI--RHYRIH 151
Query: 354 CLEH------LPAEFPSLEALVENHA 373
CL++ FPSL+ALV++++
Sbjct: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 30.8 bits (68), Expect = 2.4
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 212 DGKVYVT-AESRFSTLAELVHHHSTVADGLVTTL 244
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 30.8 bits (68), Expect = 2.4
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 167 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 227 DGKVYVT-AESRFSTLAELVHHHSTVADGLVTTL 259
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 30.8 bits (68), Expect = 2.4
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 146 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 206 DGKVYVT-AESRFSTLAELVHHHSTVADGLVTTL 238
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 30.8 bits (68), Expect = 2.4
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 290 SLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNH 349
SL ++ W +SR A LL + G+FL+ + GQ +S+R + V +++
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 350 LGRYCLEHLPAEFPSLEALVENHAVTERSLFCPL 383
G+ + + F +L LV +H+ L L
Sbjct: 212 DGKVYVT-AESRFSTLAELVHHHSTVADGLVTTL 244
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,614,288
Number of Sequences: 37866
Number of extensions: 1004991
Number of successful extensions: 3043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 3019
Number of HSP's gapped (non-prelim): 54
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.