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Search of human proteins with 156766068
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156766068 CDC42 binding protein kinase gamma (DMPK-like)
[Homo sapiens]
(1551 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 3098 0.0
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 1333 0.0
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 1320 0.0
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 1259 0.0
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 513 e-145
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 513 e-145
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 507 e-143
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 467 e-131
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 434 e-121
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 419 e-116
gi|32698688 citron [Homo sapiens] 405 e-112
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 297 5e-80
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 296 1e-79
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 221 4e-57
gi|148727255 microtubule associated serine/threonine kinase fami... 216 1e-55
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 215 3e-55
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 214 4e-55
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 213 2e-54
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 210 7e-54
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 207 6e-53
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 207 6e-53
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 201 6e-51
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 201 6e-51
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 201 6e-51
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 199 1e-50
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 199 1e-50
gi|28557781 protein kinase C, eta [Homo sapiens] 198 3e-50
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 198 3e-50
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 198 3e-50
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 198 3e-50
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 3098 bits (8031), Expect = 0.0
Identities = 1551/1551 (100%), Positives = 1551/1551 (100%)
Query: 1 MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSK 60
MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSK
Sbjct: 1 MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSK 60
Query: 61 VKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER 120
VKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER
Sbjct: 61 VKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER 120
Query: 121 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV 180
DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV
Sbjct: 121 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV 180
Query: 181 LAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISP 240
LAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISP
Sbjct: 181 LAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISP 240
Query: 241 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPD 300
EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPD
Sbjct: 241 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPD 300
Query: 301 VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPM 360
VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPM
Sbjct: 301 VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPM 360
Query: 361 DTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQ 420
DTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQ
Sbjct: 361 DTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQ 420
Query: 421 CLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGS 480
CLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGS
Sbjct: 421 CLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGS 480
Query: 481 PGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQT 540
PGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQT
Sbjct: 481 PGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQT 540
Query: 541 RALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPP 600
RALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPP
Sbjct: 541 RALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPP 600
Query: 601 EGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQ 660
EGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQ
Sbjct: 601 EGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQ 660
Query: 661 ESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTL 720
ESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTL
Sbjct: 661 ESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTL 720
Query: 721 PARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEA 780
PARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEA
Sbjct: 721 PARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEA 780
Query: 781 EKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGG 840
EKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGG
Sbjct: 781 EKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGG 840
Query: 841 EPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLML 900
EPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLML
Sbjct: 841 EPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLML 900
Query: 901 GLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPS 960
GLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPS
Sbjct: 901 GLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPS 960
Query: 961 GVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQ 1020
GVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQ
Sbjct: 961 GVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQ 1020
Query: 1021 SRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYT 1080
SRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYT
Sbjct: 1021 SRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYT 1080
Query: 1081 LKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSP 1140
LKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSP
Sbjct: 1081 LKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSP 1140
Query: 1141 SAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVK 1200
SAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVK
Sbjct: 1141 SAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVK 1200
Query: 1201 RQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLAL 1260
RQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLAL
Sbjct: 1201 RQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLAL 1260
Query: 1261 GAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM 1320
GAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM
Sbjct: 1261 GAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM 1320
Query: 1321 GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRN 1380
GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRN
Sbjct: 1321 GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRN 1380
Query: 1381 QLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPP 1440
QLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPP
Sbjct: 1381 QLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPP 1440
Query: 1441 TNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGG 1500
TNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGG
Sbjct: 1441 TNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGG 1500
Query: 1501 DADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP 1551
DADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
Sbjct: 1501 DADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP 1551
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 1333 bits (3451), Expect = 0.0
Identities = 748/1630 (45%), Positives = 1029/1630 (63%), Gaps = 147/1630 (9%)
Query: 2 ERRLRALEQ-LARGEA---GGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPF 57
E RLR LEQ + G A G C ++ LLD+L+ L+ E ++ PLRRE+++ ++L WA PF
Sbjct: 4 EVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPF 63
Query: 58 VSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFR 117
SKVK++RL R+DFEILKVIGRGAFGEV VV+ ++ ++FAMK+L+KWEMLKRAETACFR
Sbjct: 64 TSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR 123
Query: 118 EERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177
EERDVLV GD++W+TTLHYAFQD+ LYLVMDYY GGDLLTLLS+FEDRLP ++A+FYLA
Sbjct: 124 EERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
Query: 178 EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237
EMV+AI S+HQL YVHRD+KPDN+L+D+NGHIRLADFGSCL+L +G V SSVAVGTPDY
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243
Query: 238 ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297
ISPEILQAME+GKG YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNH++ QF
Sbjct: 244 ISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQF 303
Query: 298 PPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELR 357
P V DV +A+DLIR+L+C +E RLG+ G++DF+ HPFF G+DW+ + + APYIPE+
Sbjct: 304 PAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVS 363
Query: 358 GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSG-----------SHSPE 406
P DTSNFDVDDD L + T+PPP+H AFSGHHLPFVGFTYTS + P
Sbjct: 364 SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPT 423
Query: 407 S------------SSEAWAALERKLQCLEQEKVELSRKHQEALH--------------AP 440
S ++ A A ER+++ LEQEK+ELSRK QE+
Sbjct: 424 SLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTA 483
Query: 441 TDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAE 500
+ E++ L++E++ LR ++ E + L + + +RQELD R+
Sbjct: 484 SKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANA-----------VRQELDDAFRQ--- 529
Query: 501 GRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEE-ARAAQRELEA 559
++A E+++ Q Q+ E L +L+ E AA AS+ R L Q E ++ + ELE
Sbjct: 530 ----IKAYEKQIKTLQ-QEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEG 584
Query: 560 ----QVS--------SLSRQVTQLQGQWEQRL----EESSQAKTIHTASETNGMGPP--E 601
Q+S +++T+L+ E++ EE S+ + IH A+E + +
Sbjct: 585 LKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIH-ANEIKNLKKELHD 643
Query: 602 GGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQ-----------LQEENRRLSREQE 650
Q+ L KE+ L+++LE+ S +EE + L EEN++L+ E +
Sbjct: 644 SEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELD 703
Query: 651 RLEAELAQEQESKQRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYLQALATK 704
+L Q+LE E ++E+ ++WEAQ+ +I+ WV+DEK +RGYLQALA+K
Sbjct: 704 KLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASK 763
Query: 705 MAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLT 764
M EELE+LRN +L R D WK RR K++ SARLELQSAL+AEIRAKQ +QE L
Sbjct: 764 MTEELEALRN---SSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELN 820
Query: 765 QVQEAQLQAERRLQEAEKQSQALQQELAML---REELRARGPVDTKPSNSLIPFLSFRSS 821
+V+ + + E +L+++EK++ L E+ L EELR+ ++ + S FL+F ++
Sbjct: 821 KVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQH--SFLAFLNT 878
Query: 822 EKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTL 881
D+ P LR +G + G P K +H
Sbjct: 879 PTDALDQFETVDSTPLSVHTPTLRKKG-----------------CPGSTGFPPKRKTHQF 921
Query: 882 RPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAP-PCPVPPDLLRTALGV 940
+SF +PTKC +CTSLM+GL RQG C+ CG+ CH TC +AP CPVPP+ + LG+
Sbjct: 922 FVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGI 981
Query: 941 HPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLD 1000
P+ G GTAYEG + +P+P+GV++GWQR A + D +L L+D + + S PS + QV+D
Sbjct: 982 DPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVID 1041
Query: 1001 LRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQV 1060
+RD +FS + VLASDVIHA +D+P IFRVT SQL+ C++L+LA++E E+ +W+ V
Sbjct: 1042 MRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGV 1101
Query: 1061 LGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLR 1120
L EL ++L + R R VY KEAYD+ LPL+ T AAI+D +R+ALG EEGLFV+H+
Sbjct: 1102 LSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVT 1161
Query: 1121 SNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQ 1180
++I +VG+ +++ Q+ L P+ L+ V+ GR VRLF ++ L+ E K+ E++GCQ
Sbjct: 1162 KDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQ 1221
Query: 1181 VLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCV 1240
+ +G + LCVA+KRQVLCY+L R+ +E+Q P VQ + + ++LCV
Sbjct: 1222 TVTSGKVRHGALTCLCVAMKRQVLCYELFQSK-TRHRKFKEIQVPYNVQWMAIFSEQLCV 1280
Query: 1241 GAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIY 1300
G GF YPL E P ++ L +A+ AVE+S E+LL F + GIY
Sbjct: 1281 GFQSGFLRYPLNGEGNPYSM-LHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIY 1339
Query: 1301 VDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLN 1360
D GR+SR EL+WPA P Y APYL+V+SEN++D+FDV EW+QT+PLKKVRPLN
Sbjct: 1340 TDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLN 1399
Query: 1361 PEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRT-KSKRRFFFRVSEEQQ 1419
EGSL L G E +RL Y +N++AE DE +P+ +DNSR+Q+ R +KRR+ FRV EE++
Sbjct: 1400 NEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEER 1459
Query: 1420 KQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD--KSPAPEEKGRVARGS-- 1475
QQRREML+DP +R+KLIS PTNFNH+ H+GP +G +D +P P+E V GS
Sbjct: 1460 MQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVS 1519
Query: 1476 ---------GPQRPHSFSEAL--RRPASMGS---EGLGGDADPMKRKPWTSLSSESVS-- 1519
P R S S L R A GS G + KR+P S S S+S
Sbjct: 1520 IPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSG 1579
Query: 1520 -CPQGSLSPA 1528
QGS +PA
Sbjct: 1580 GMDQGSDAPA 1589
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 1320 bits (3417), Expect = 0.0
Identities = 756/1693 (44%), Positives = 1028/1693 (60%), Gaps = 192/1693 (11%)
Query: 2 ERRLRALEQ-LARGEA---GGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPF 57
E RLR LEQ + G A G C ++ LLD+L+ L+ E ++ PLRRE+++ ++L WA PF
Sbjct: 4 EVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPF 63
Query: 58 VSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFR 117
SKVK++RL R+DFEILKVIGRGAFGEV VV+ ++ ++FAMK+L+KWEMLKRAETACFR
Sbjct: 64 TSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR 123
Query: 118 EERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177
EERDVLV GD++W+TTLHYAFQD+ LYLVMDYY GGDLLTLLS+FEDRLP ++A+FYLA
Sbjct: 124 EERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
Query: 178 EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237
EMV+AI S+HQL YVHRD+KPDN+L+D+NGHIRLADFGSCL+L +G V SSVAVGTPDY
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243
Query: 238 ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297
ISPEILQAME+GKG YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNH++ QF
Sbjct: 244 ISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQF 303
Query: 298 PPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELR 357
P V DV +A+DLIR+L+C +E RLG+ G++DF+ HPFF G+DW+ + + APYIPE+
Sbjct: 304 PAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVS 363
Query: 358 GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSG-----------SHSPE 406
P DTSNFDVDDD L + T+PPP+H AFSGHHLPFVGFTYTS + P
Sbjct: 364 SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPT 423
Query: 407 S------------SSEAWAALERKLQCLEQEKVELSRKHQEA---------------LHA 439
S ++ A A ER+++ LEQEK+ELSRK QE+ L A
Sbjct: 424 SLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTA 483
Query: 440 PTD------HRELEQLRKEVQT---LRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQE 490
D E+E+LRK+V L +L E + L Q L+QE
Sbjct: 484 SKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQE 543
Query: 491 LDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQER--EAATASQTRA------ 542
+ L++EL + L+ Q +EL A Q++ +Q E ER E T Q A
Sbjct: 544 REDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDK 603
Query: 543 -------------LSSQLEEARAAQRELEAQVSSLS------------------------ 565
L +L A++ELE +L+
Sbjct: 604 EEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENEL 663
Query: 566 --------------------RQVTQLQGQWEQRL----EESSQAKTIHTASETN---GMG 598
+++T+L+ E++ EE S+ + IH N +
Sbjct: 664 EGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELH 723
Query: 599 PPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQ-----------LQEENRRLSR 647
EG Q+ L KE+ L+++LE+ S +EE + L EEN++L+
Sbjct: 724 DSEG--QQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTS 781
Query: 648 EQERLEAELAQEQESKQRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYLQAL 701
E ++L Q+LE E ++E+ ++WEAQ+ +I+ WV+DEK +RGYLQAL
Sbjct: 782 ELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQAL 841
Query: 702 ATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQE 761
A+KM EELE+LRN +L R D WK RR K++ SARLELQSAL+AEIRAKQ +QE
Sbjct: 842 ASKMTEELEALRN---SSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQE 898
Query: 762 RLTQVQEAQLQAERRLQEAEKQSQALQQELAML---REELRARGPVDTKPSNSLIPFLSF 818
L +V+ + + E +L+++EK++ L E+ L EELR+ ++ + S FL+F
Sbjct: 899 ELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQH--SFLAF 956
Query: 819 RSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGS 878
++ D+ P LR +G + G P K +
Sbjct: 957 LNTPTDALDQFETVDSTPLSVHTPTLRKKG-----------------CPGSTGFPPKRKT 999
Query: 879 HTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPP-CPVPPDLLRTA 937
H +SF +PTKC +CTSLM+GL RQG C+ CG+ CH TC +AP CPVPP+ +
Sbjct: 1000 HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGP 1059
Query: 938 LGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQ 997
LG+ P+ G GTAYEG + +P+P+GV++GWQR A + D +L L+D + + S PS + Q
Sbjct: 1060 LGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQ 1119
Query: 998 VLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERW 1057
V+D+RD +FS + VLASDVIHA +D+P IFRVT SQL+ C++L+LA++E E+ +W
Sbjct: 1120 VIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKW 1179
Query: 1058 LQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVI 1117
+ VL EL ++L + R R VY KEAYD+ LPL+ T AAI+D +R+ALG EEGLFV+
Sbjct: 1180 VGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVV 1239
Query: 1118 HLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESR 1177
H+ ++I +VG+ +++ Q+ L P+ L+ V+ GR VRLF ++ L+ E K+ E++
Sbjct: 1240 HVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETK 1299
Query: 1178 GCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDR 1237
GCQ + +G + LCVA+KRQVLCY+L R+ +E+Q P VQ + + ++
Sbjct: 1300 GCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSK-TRHRKFKEIQVPYNVQWMAIFSEQ 1358
Query: 1238 LCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTA 1297
LCVG GF YPL E P ++ L +A+ AVE+S E+LL F +
Sbjct: 1359 LCVGFQSGFLRYPLNGEGNPYSM-LHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSI 1417
Query: 1298 GIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVR 1357
GIY D GR+SR EL+WPA P Y APYL+V+SEN++D+FDV EW+QT+PLKKVR
Sbjct: 1418 GIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVR 1477
Query: 1358 PLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRT-KSKRRFFFRVSE 1416
PLN EGSL L G E +RL Y +N++AE DE +P+ +DNSR+Q+ R +KRR+ FRV E
Sbjct: 1478 PLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPE 1537
Query: 1417 EQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD--KSPAPEEKGRVARG 1474
E++ QQRREML+DP +R+KLIS PTNFNH+ H+GP +G +D +P P+E V G
Sbjct: 1538 EERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSG 1597
Query: 1475 S-----------GPQRPHSFSEAL--RRPASMGS---EGLGGDADPMKRKPWTSLSSESV 1518
S P R S S L R A GS G + KR+P S S S+
Sbjct: 1598 SVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSL 1657
Query: 1519 S---CPQGSLSPA 1528
S QGS +PA
Sbjct: 1658 SSGGMDQGSDAPA 1670
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 1259 bits (3257), Expect = 0.0
Identities = 715/1657 (43%), Positives = 1007/1657 (60%), Gaps = 178/1657 (10%)
Query: 4 RLRALEQLA-----RGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFV 58
RL+ LEQL R E+ ++ LLD+L+ L+ E S LRR++ VA+FL WA PF
Sbjct: 6 RLKKLEQLLLDGPWRNESA--LSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFT 63
Query: 59 SKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFRE 118
VKE++L R+DFEI+KVIGRGAFGEV VV+ ++T +I+AMK+L+KWEMLKRAETACFRE
Sbjct: 64 QLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFRE 123
Query: 119 ERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAE 178
ERDVLV GD +W+T LHYAFQDE +LYLVMDYY GGDLLTLLS+FED+LP ++A+FY+ E
Sbjct: 124 ERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGE 183
Query: 179 MVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYI 238
MVLAI S+HQL YVHRD+KPDNVLLDVNGHIRLADFGSCL++N +G V SSVAVGTPDYI
Sbjct: 184 MVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYI 243
Query: 239 SPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFP 298
SPEILQAME+G G YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNHE+ QFP
Sbjct: 244 SPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFP 303
Query: 299 PDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRG 358
V DV A+DLI++L+C +E RLG+ G++DF+ H FFEG++WE + + APYIP++
Sbjct: 304 SHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSS 363
Query: 359 PMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEA------- 411
P DTSNFDVDDD L + LPP SH FSG HLPF+GFT+T+ S + S
Sbjct: 364 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNT 423
Query: 412 ----------------WAALERKLQCLEQEKVELSRKHQE-------------ALHAPTD 442
A ER+++ LEQEK+ELSRK QE AL
Sbjct: 424 LTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNR 483
Query: 443 HRELEQLRKEVQTLRD------RLPEMLRDKASLSQTDGPPA----GSPGQDSDLRQELD 492
+E+++L +E++ L++ RL L D +L Q G Q +RQE +
Sbjct: 484 DKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKE 543
Query: 493 RLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEE--- 549
LH++L E L++Q +EL A Q++ LQ E ER A +Q + +S QL +
Sbjct: 544 ELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEE 603
Query: 550 ------------------ARAAQRELEAQVSSL--------------------------- 564
A ++ELEAQ+
Sbjct: 604 EMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEA 663
Query: 565 ----------------SRQVTQLQGQWEQRL----EESSQAKTIHTASETNGMGPP-EGG 603
+++++++ + E+++ EE + + H N +
Sbjct: 664 LKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSE 723
Query: 604 PQEAQLRKEVAALREQLEQAHSHRPSGKEEAL-----------CQLQEENRRLSREQERL 652
+ L+KE+ L+++LE++ R + EEA+ L +EN++L+ E E+L
Sbjct: 724 SHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKL 783
Query: 653 EAELAQEQESKQRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYLQALATKMA 706
+ + + ++LE E ++E+ ++WEAQ+A+I+ WV+DEK +RGYLQALA+KM
Sbjct: 784 CSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMT 843
Query: 707 EELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQV 766
EELE+LR+ +L +R LD WK RR QK++ SARLELQSALEAEIRAKQ +QE L +V
Sbjct: 844 EELEALRS---SSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV 900
Query: 767 QEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPS-----NSLIPFLSFRSS 821
++A L E +L+++E +++ L +E+ +L++++ + DT +S+ + +
Sbjct: 901 KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL 960
Query: 822 EKDSAKDPGISGEATRHGGEPDLRP-------EGRRSLRMGAVFPRA---PTANTASTEG 871
D + E +P+ P E + + P A PT + G
Sbjct: 961 AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG 1020
Query: 872 LPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPP-CPVP 930
KP +H +SF SPT+C CTSLM+GL RQG C+ C + CH +C AP CP+P
Sbjct: 1021 --PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIP 1078
Query: 931 PDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSP 990
P+ + LGV + G GTAY+G + VP+P+GV++GWQR +A + D +L L+D P+ + +
Sbjct: 1079 PEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQ 1138
Query: 991 PSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAES 1050
P QVLDLRD +FS + VLASDVIHA RD+P IFRVT S L P T ++L+L E+
Sbjct: 1139 PGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTEN 1198
Query: 1051 EGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGT 1110
E E+ +W+ +L LQ +L R R + V+ EAYD+ LPL+ L AAI+D DR+A+G
Sbjct: 1199 ENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGL 1258
Query: 1111 EEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVA- 1169
EEGL+VI + + I + +C++V Q+ L+P ++++LCGR V L+ + L+ E +
Sbjct: 1259 EEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSF 1318
Query: 1170 GAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQ 1229
K+PE++GCQ++A ++ + L VAVKR +LCY++ P+ R+ E+ AP +VQ
Sbjct: 1319 DIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEI-QRTKPFHRKFNEIVAPGSVQ 1377
Query: 1230 SLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLG----EALGAVEL 1285
L +L DRLCVG GF L + + PL L + P + PS L +AL AVEL
Sbjct: 1378 CLAVLRDRLCVGYPSGFCLLSIQGDGQPLNL---VNPND--PSLAFLSQQSFDALCAVEL 1432
Query: 1286 SLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRA 1345
E+LL F+ G+YVD GR++R EL+WPAAP+ + ++TV+SE +DVFDVR
Sbjct: 1433 ESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTM 1492
Query: 1346 EWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTK 1405
EWVQT+ L+++RPLN EG+L L E RL Y +++ + ++PD +DNS++Q+ RT+
Sbjct: 1493 EWVQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGA-VLNVPDTSDNSKKQMLRTR 1551
Query: 1406 SKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD----- 1460
SKRRF F+V EE++ QQRREML+DP +RSK+IS PTNFNH+ H+GP +G D
Sbjct: 1552 SKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSA 1611
Query: 1461 KSPAPEEK-GRVARGSGPQRPHSFSEALRRPASMGSE 1496
P+ EE+ G Q P + P+S GSE
Sbjct: 1612 VPPSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSE 1648
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 513 bits (1321), Expect = e-145
Identities = 281/575 (48%), Positives = 361/575 (62%), Gaps = 55/575 (9%)
Query: 2 ERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKV 61
E RLR L+QL G GL+ LLDLLL +H EL + L +++ VA FL WA P V ++
Sbjct: 4 EVRLRRLQQLVLDP--GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRL 61
Query: 62 KELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERD 121
KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E +CFREERD
Sbjct: 62 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 121
Query: 122 VLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVL 181
VLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+FYLAE+V+
Sbjct: 122 VLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
Query: 182 AIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPE 241
AI S+H+LGYVHRD+KPDN+LLD GHIRLADFGSCL+L +G V S VAVGTPDY+SPE
Sbjct: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
Query: 242 ILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPP 299
ILQA+ G G YGP+CDWW+LGV AYE+ +G+TPFYA+S ETYGKI+++++HL P
Sbjct: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
Query: 300 DVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGP 359
VP A+D I++LLC E RLGRGG DFR HPFF G+DW+ L S P+ P+ G
Sbjct: 302 VDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGA 361
Query: 360 MDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKL 419
DT NFD+ +D L TL GA G HLPFVG++Y+ +
Sbjct: 362 TDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSC------------------M 403
Query: 420 QCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG 479
+ E + EA H + L V +D E+ PA
Sbjct: 404 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV-----------AVPAA 451
Query: 480 SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQ 539
P +++ L REL E +EE+L R ++E E A +
Sbjct: 452 VPAAEAEAEVTL----RELQE----------------ALEEEVLTRQSLSREME-AIRTD 490
Query: 540 TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574
+ +SQL EA A R+LEA V L ++ LQ +
Sbjct: 491 NQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
Score = 33.5 bits (75), Expect = 1.6
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
ELQ ALE E+ +Q L + ++ +L+EAE +++ L+ + L+E +
Sbjct: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 519
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 513 bits (1321), Expect = e-145
Identities = 281/575 (48%), Positives = 361/575 (62%), Gaps = 55/575 (9%)
Query: 2 ERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKV 61
E RLR L+QL G GL+ LLDLLL +H EL + L +++ VA FL WA P V ++
Sbjct: 4 EVRLRRLQQLVLDP--GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRL 61
Query: 62 KELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERD 121
KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E +CFREERD
Sbjct: 62 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 121
Query: 122 VLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVL 181
VLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+FYLAE+V+
Sbjct: 122 VLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
Query: 182 AIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPE 241
AI S+H+LGYVHRD+KPDN+LLD GHIRLADFGSCL+L +G V S VAVGTPDY+SPE
Sbjct: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
Query: 242 ILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPP 299
ILQA+ G G YGP+CDWW+LGV AYE+ +G+TPFYA+S ETYGKI+++++HL P
Sbjct: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
Query: 300 DVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGP 359
VP A+D I++LLC E RLGRGG DFR HPFF G+DW+ L S P+ P+ G
Sbjct: 302 VDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGA 361
Query: 360 MDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKL 419
DT NFD+ +D L TL GA G HLPFVG++Y+ +
Sbjct: 362 TDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSC------------------M 403
Query: 420 QCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG 479
+ E + EA H + L V +D E+ PA
Sbjct: 404 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV-----------AVPAA 451
Query: 480 SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQ 539
P +++ L REL E +EE+L R ++E E A +
Sbjct: 452 VPAAEAEAEVTL----RELQE----------------ALEEEVLTRQSLSREME-AIRTD 490
Query: 540 TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574
+ +SQL EA A R+LEA V L ++ LQ +
Sbjct: 491 NQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
Score = 33.5 bits (75), Expect = 1.6
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
ELQ ALE E+ +Q L + ++ +L+EAE +++ L+ + L+E +
Sbjct: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 519
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 507 bits (1305), Expect = e-143
Identities = 281/580 (48%), Positives = 361/580 (62%), Gaps = 60/580 (10%)
Query: 2 ERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKV 61
E RLR L+QL G GL+ LLDLLL +H EL + L +++ VA FL WA P V ++
Sbjct: 4 EVRLRRLQQLVLDP--GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRL 61
Query: 62 KELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERD 121
KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E +CFREERD
Sbjct: 62 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 121
Query: 122 VLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVL 181
VLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+FYLAE+V+
Sbjct: 122 VLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
Query: 182 AIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPE 241
AI S+H+LGYVHRD+KPDN+LLD GHIRLADFGSCL+L +G V S VAVGTPDY+SPE
Sbjct: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
Query: 242 ILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPP 299
ILQA+ G G YGP+CDWW+LGV AYE+ +G+TPFYA+S ETYGKI+++++HL P
Sbjct: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
Query: 300 DVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGP 359
VP A+D I++LLC E RLGRGG DFR HPFF G+DW+ L S P+ P+ G
Sbjct: 302 VDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGA 361
Query: 360 MDTSNFDVDDDTL-----NHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAA 414
DT NFD+ +D L TL GA G HLPFVG++Y+
Sbjct: 362 TDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSC-------------- 407
Query: 415 LERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTD 474
+ + E + EA H + L V +D E+
Sbjct: 408 ----MALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV----------- 451
Query: 475 GPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREA 534
PA P +++ L REL E +EE+L R ++E E
Sbjct: 452 AVPAAVPAAEAEAEVTL----RELQE----------------ALEEEVLTRQSLSREME- 490
Query: 535 ATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574
A + + +SQL EA A R+LEA V L ++ LQ +
Sbjct: 491 AIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 530
Score = 33.5 bits (75), Expect = 1.6
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
ELQ ALE E+ +Q L + ++ +L+EAE +++ L+ + L+E +
Sbjct: 470 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 524
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 467 bits (1202), Expect = e-131
Identities = 256/528 (48%), Positives = 329/528 (62%), Gaps = 58/528 (10%)
Query: 54 ASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAET 113
A P V ++KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E
Sbjct: 64 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
Query: 114 ACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQ 173
+CFREERDVLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
Query: 174 FYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVG 233
FYLAE+V+AI S+H+LGYVHRD+KPDN+LLD GHIRLADFGSCL+L +G V S VAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
Query: 234 TPDYISPEILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNH 291
TPDY+SPEILQA+ G G YGP+CDWW+LGV AYE+ +G+TPFYA+S ETYGKI+++
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
Query: 292 EDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAP 351
++HL P VP A+D I++LLC E RLGRGG DFR HPFF G+DW+ L S P
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 352 YIPELRGPMDTSNFDVDDDTL-----NHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPE 406
+ P+ G DT NFD+ +D L TL GA G HLPFVG++Y+
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSC------ 417
Query: 407 SSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRD 466
+ + E + EA H + L V +D E+
Sbjct: 418 ------------MALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV--- 461
Query: 467 KASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRL 526
PA P +++ L REL E +EE+L R
Sbjct: 462 --------AVPAAVPAAEAEAEVTL----RELQE----------------ALEEEVLTRQ 493
Query: 527 QEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574
++E E A + + +SQL EA A R+LEA V L ++ LQ +
Sbjct: 494 SLSREME-AIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540
Score = 33.5 bits (75), Expect = 1.6
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
ELQ ALE E+ +Q L + ++ +L+EAE +++ L+ + L+E +
Sbjct: 480 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 534
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 434 bits (1115), Expect = e-121
Identities = 297/885 (33%), Positives = 468/885 (52%), Gaps = 129/885 (14%)
Query: 23 DGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAF 82
D LLD L AL ++L LR+ +++ FLS ++K+++LR++ +D+E++KVIGRGAF
Sbjct: 28 DCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAF 87
Query: 83 GEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEE 142
GEV +VR + T +++AMK+L K+EM+KR+++A F EERD++ +S WV L YAFQD+
Sbjct: 88 GEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDR 147
Query: 143 YLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVL 202
YLY+VM+Y GGDL+ L+S ++ +P + A+FY AE+VLA+ ++H +G++HRDVKPDN+L
Sbjct: 148 YLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNML 205
Query: 203 LDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSL 262
LD +GH++LADFG+C+++N GMV AVGTPDYISPE+L++ + G G+YG +CDWWS+
Sbjct: 206 LDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSV 264
Query: 263 GVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEER 322
GV YE+L G+TPFYA+SLV TY KIMNH++ L FP D D+ A++LI L +E R
Sbjct: 265 GVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDD-NDISKEAKNLICAFLTDREVR 323
Query: 323 LGRGGLDDFRNHPFFEGVD--WERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPP 380
LGR G+++ + H FF+ WE L + AP +P+L +DTSNFD ++ T P
Sbjct: 324 LGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPI 383
Query: 381 PSHGAFSGHHLPFVGFTYTS-----GSHSP---ESSSEAWAALERKLQ----CLEQE--- 425
P AF G+ LPFVGFTY S S +P +SS A +L+ LQ LE++
Sbjct: 384 PK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHN 441
Query: 426 ---------------KVELSRKHQEALHAPTDHRELE----QLRKEVQTLRDRLPEMLR- 465
++L + +E R LE Q+ KE L+ R+ E R
Sbjct: 442 EMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRK 501
Query: 466 ------------DKASLSQTDGPPAGSPGQDSDLRQE-LDRLHRELAEGR---------- 502
++ S + Q+S L E L +L ++L E
Sbjct: 502 AEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTA 561
Query: 503 AGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQR------- 555
L+ E+ ++ Q E L + LQE + SQT QL+ A+R
Sbjct: 562 VRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDS 621
Query: 556 ----ELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTI--HTASETNGMGPPEGGPQEAQL 609
+L+A+++SL +V L+ E+ E +A+ + H+ E N + E L
Sbjct: 622 EMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNL--------EIDL 673
Query: 610 RKEVAALREQLEQ--------------AHSHRPSGKEEALCQLQE------------ENR 643
++ +L+++LEQ H K A+C++++ ENR
Sbjct: 674 NYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENR 733
Query: 644 --RLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQAL 701
++ ++ L+ +L Q Q+ + L G + E ++ ++ + E R LQ
Sbjct: 734 VVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMED----EVKNLTLQLEQESNKRLLLQNE 789
Query: 702 ATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQE 761
A E ++L+ G + + ++ +A+RL + E + + E ++R Q E
Sbjct: 790 LKTQAFEADNLK--GLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLE 847
Query: 762 R--------LTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
TQV+E + + E + +E K+ Q LQ E L +L
Sbjct: 848 AEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQL 892
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 7/82 (8%)
Query: 951 EGFLSVPRPSGVRR-GWQRVFAALSDSRLLLF-DAPDLRLSPPSGALLQVLDLRDPQFSA 1008
EG+LSVP ++R GW++ + +S ++L + D D S PS VLD+ D F
Sbjct: 1122 EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPS----MVLDI-DKLFHV 1176
Query: 1009 TPVLASDVIHAQSRDLPRIFRV 1030
PV DV A++ ++P+IF++
Sbjct: 1177 RPVTQGDVYRAETEEIPKIFQI 1198
Score = 45.4 bits (106), Expect = 4e-04
Identities = 61/308 (19%), Positives = 124/308 (40%), Gaps = 62/308 (20%)
Query: 447 EQLRKEVQTLRD--RLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAG 504
+Q+++E+ TL + RL E L+Q G+ GQ +L+ +L+ +
Sbjct: 805 KQMKQEINTLLEAKRLLEF-----ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQ 859
Query: 505 LQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSL 564
++ ++E+ + + E L+++QE Q + A+Q ++ E + A+ LE Q L
Sbjct: 860 VKELKEEI---EEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFEL 916
Query: 565 SRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAH 624
+++ + + Q + + T+ E N M + LR+E L E++++A
Sbjct: 917 TQESKKAASRNRQEITDKDH--TVSRLEEANSMLTKD----IEILRRENEELTEKMKKAE 970
Query: 625 SHRPSGKEEALCQLQ---------------------------------------EENRRL 645
KEE + L+ ++ R+
Sbjct: 971 EEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKK 1030
Query: 646 SREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKM 705
+E +L+ EL QE+E ++ + ++ ++ +AQL +E R LQ
Sbjct: 1031 EKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV-------EECAHRNELQMQLASK 1083
Query: 706 AEELESLR 713
++E LR
Sbjct: 1084 ESDIEQLR 1091
Score = 45.1 bits (105), Expect = 5e-04
Identities = 92/434 (21%), Positives = 170/434 (39%), Gaps = 80/434 (18%)
Query: 402 SHSPESSS-EAWAALERKLQ----CLEQEKVELSRKH---QEALHAPT-----DHRELEQ 448
SH+ S S +L R+LQ LE K + + + Q L A D +
Sbjct: 567 SHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGD 626
Query: 449 LRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQ 508
L+ + +L++ + + K +L + +G + + +E + L +L LQ +
Sbjct: 627 LQARITSLQEEVKHL---KHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQR 683
Query: 509 -EQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQ 567
EQE+ + + L + Q +E ++ + + +L+E R A+ + E +V + +Q
Sbjct: 684 LEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE---MEKKLKEEREAREKAENRVVQIEKQ 740
Query: 568 VTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHR 627
+ L +Q SQ K H + ++ EV L QLEQ + R
Sbjct: 741 CSMLDVDLKQ-----SQQKLEHLTGN------------KERMEDEVKNLTLQLEQESNKR 783
Query: 628 PSGKEEALCQ-------------LQEENRRLSREQERLEAELAQEQESKQRLEGERRETE 674
+ E Q +++E L + LE ELAQ + + EG+ RE +
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
Query: 675 SNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRL 734
EA E+ + ++ EE+E + + + + A +L
Sbjct: 844 DQLEA-----------EQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQL 892
Query: 735 QKMEASARLELQSALEAEIRAKQGLQERLTQV-QEAQLQAERRLQE----------AEKQ 783
E A E+E A+ L+E+ ++ QE++ A R QE E+
Sbjct: 893 DLAETKA--------ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEA 944
Query: 784 SQALQQELAMLREE 797
+ L +++ +LR E
Sbjct: 945 NSMLTKDIEILRRE 958
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 419 bits (1076), Expect = e-116
Identities = 272/818 (33%), Positives = 451/818 (55%), Gaps = 91/818 (11%)
Query: 4 RLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKE 63
R R LE L R ++ LLD L +L +L LR+ +++ FL+ V K++
Sbjct: 26 RQRKLEALIRDPRSPI-NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRG 84
Query: 64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL 123
L+++ +D++++KVIGRGAFGEV +VR + + +++AMK+L K+EM+KR+++A F EERD++
Sbjct: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
Query: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183
+S WV L YAFQD+ YLY+VM+Y GGDL+ L+S ++ +P + A+FY AE+VLA+
Sbjct: 145 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLAL 202
Query: 184 HSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEIL 243
++H +G +HRDVKPDN+LLD +GH++LADFG+C++++ GMV AVGTPDYISPE+L
Sbjct: 203 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 262
Query: 244 QAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPD 303
++ + G G YG +CDWWS+GV YE+L G+TPFYA+SLV TY KIM+H++ L FP D +
Sbjct: 263 KS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDA-E 320
Query: 304 VPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVD--WERLASSTAPYIPELRGPMD 361
+ A++LI L +E RLGR G+++ R HPFF+ W+ + + AP +PEL +D
Sbjct: 321 ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 380
Query: 362 TSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQC 421
+SNFD +D T P P AF G+ LPF+GFTY + L C
Sbjct: 381 SSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTYYREN----------LLLSDSPSC 428
Query: 422 LEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSP 481
E + ++ SRK++E+ ++++K++ TL + L ++ K L Q
Sbjct: 429 RETDSIQ-SRKNEES----------QEIQKKLYTLEEHLSNEMQAKEELEQ--------- 468
Query: 482 GQDSDLRQELDRLHRELAEG-------RAGLQAQEQELCRAQGQQEELLQRLQEAQEREA 534
+ + L++ +EL E + L+ E+E Q + E ++ +++
Sbjct: 469 -KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKR 527
Query: 535 ATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASET 594
+ +L QLE+ + +R +Q+S + +V QLQ Q L+E++ + T S+T
Sbjct: 528 NLENDVNSLKDQLEDLK--KRNQNSQIS--TEKVNQLQRQ----LDETN--ALLRTESDT 577
Query: 595 NGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEA 654
A+LRK A +Q++Q S+ ++ C L E +L E+E +
Sbjct: 578 -----------AARLRKTQAESSKQIQQLESNN-RDLQDKNCLL--ETAKLKLEKEFINL 623
Query: 655 ELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKV-------SRGYLQALATKMAE 707
+ A E E + R G E ++ + ++ + + + K+ + LQ T + +
Sbjct: 624 QSALESERRDRTHGS--EIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 681
Query: 708 ELESLR-------NVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQ 760
E ++ V Q+L +H+ RL A +S EA+ A + ++
Sbjct: 682 EKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARL----ADKNKIYESIEEAKSEAMKEME 737
Query: 761 ERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
++L + + + + E L EAEK+ L +L ++++
Sbjct: 738 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKI 775
Score = 64.7 bits (156), Expect = 7e-10
Identities = 95/427 (22%), Positives = 173/427 (40%), Gaps = 60/427 (14%)
Query: 406 ESSSEAWAALERKLQCLEQ----EKVE--LSRKHQEALHAPTDHRELEQLRKEVQTLRDR 459
E+ SEA +E+KL LE+ +KVE L + D ++ +Q E+ +D
Sbjct: 727 EAKSEAMKEMEKKL--LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV 784
Query: 460 LPEMLRD----------KASLSQTDGPPAGSPGQDSDLRQ-ELDRLHRELAEGRAGLQAQ 508
L E +R+ K L+Q D + + +L + + L E + L+ Q
Sbjct: 785 LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ 844
Query: 509 EQELCR----AQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSL 564
EL + A GQ +EL +L+ Q +Q R L + EE +EL+ + L
Sbjct: 845 NAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQEL 904
Query: 565 SRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQ-- 622
+ L Q E L ++ + + +E Q + L KE ++++
Sbjct: 905 QDERDSLAAQLEITLTKADSEQLARSIAE----------EQYSDLEKEKIMKELEIKEMM 954
Query: 623 -AHSHRPSGKEEALCQLQEENR-------RLSREQERLEAELAQEQESKQRLEGERRETE 674
H + K+ + L+E NR L+ E+E L +L QE RL+ E
Sbjct: 955 ARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE----- 1009
Query: 675 SNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRL 734
E A I + + ++ + L T+ +L + N D + K +
Sbjct: 1010 ---EISAAAIKAQFEKQLLTE---RTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKEN 1063
Query: 735 QKMEASARLELQSALEAEIRAKQGLQERLTQV-QEAQLQAERRLQEAEKQSQALQQELAM 793
+K+ + E + + I+ ++ L E Q+ +E+Q++ E ++ K S ++
Sbjct: 1064 RKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDS-----DIEQ 1118
Query: 794 LREELRA 800
LR +L+A
Sbjct: 1119 LRSQLQA 1125
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 7/82 (8%)
Query: 951 EGFLSVPRPSGVRR-GWQRVFAALSDSRLLLFDAP-DLRLSPPSGALLQVLDLRDPQFSA 1008
EG+LS+P + ++ GW + + +S ++L +D+ D S P VLD+ D F
Sbjct: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP----YMVLDI-DKLFHV 1208
Query: 1009 TPVLASDVIHAQSRDLPRIFRV 1030
PV +DV A ++++PRIF++
Sbjct: 1209 RPVTQTDVYRADAKEIPRIFQI 1230
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 405 bits (1040), Expect = e-112
Identities = 254/807 (31%), Positives = 430/807 (53%), Gaps = 44/807 (5%)
Query: 23 DGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAF 82
+G+LD L L E S L + + V+ F+ S +++++EL+ DFE+ ++G G F
Sbjct: 49 EGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHF 108
Query: 83 GEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEE 142
EV VVR++ TG I+AMK++ K +L + + + F EER++L + S W+ L YAFQD+
Sbjct: 109 AEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKN 168
Query: 143 YLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVL 202
+LYLVM+Y GGDLL+LL+R+ED+L L QFYLAE++LA+HS+H +GYVHRD+KP+N+L
Sbjct: 169 HLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENIL 228
Query: 203 LDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAME-EGKGHYGPQCDWWS 261
+D GHI+L DFGS ++N+N MV++ + +GTPDY++PE+L M +GKG YG CDWWS
Sbjct: 229 VDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWS 288
Query: 262 LGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEE 321
+GV AYE+++G +PF + T+ IMN + L+FP D P V + DLI+ LLC Q+E
Sbjct: 289 VGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQKE 347
Query: 322 RLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPP 381
RL GL HPFF +DW + +S P++P L+ DTSNFD + +
Sbjct: 348 RLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQL 404
Query: 382 SHGAFSGHHLPFVGFTYT-------------SGSHSPESSSEAWAAL----------ERK 418
S FSG LPFVGF+Y+ SG SP +S L + K
Sbjct: 405 SPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDK 464
Query: 419 LQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQ--TLRDRLPEMLRDKASLSQTDGP 476
+EQE L R+ E + A +E+E E Q L L + + +SL ++
Sbjct: 465 CHKMEQEMTRLHRRVSE-VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQ 523
Query: 477 PAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAAT 536
Q+ D + L LH + R + +EQE Q Q EE+ + + +E +
Sbjct: 524 ARMEVSQEDD--KALQLLHDIREQSRKLQEIKEQEY---QAQVEEMRLMMNQLEEDLVSA 578
Query: 537 ASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNG 596
++ S+L E+R A E + + + ++ + + Q + + E ++ + I+ +
Sbjct: 579 RRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKI 638
Query: 597 MGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSR---EQERLE 653
E + + E L + + QA R + E L ++ + + + E E LE
Sbjct: 639 QELQEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEELE 697
Query: 654 AELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEEL-ESL 712
+ + Q S Q LE ++ E ++E ++ + + + + + L+ + + EE E
Sbjct: 698 EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKG 757
Query: 713 RNVGTQTLPARPLDHQWKA--RRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQ 770
+ + Q +D + ++ +R+ ++ + +L S+L + R + +E ++++++ +
Sbjct: 758 KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQ-RNMKAQEEMISELRQQK 816
Query: 771 LQAERRLQEAEKQSQALQQELAMLREE 797
E + + E Q++ L+++L + +
Sbjct: 817 FYLETQAGKLEAQNRKLEEQLEKISHQ 843
Score = 144 bits (362), Expect = 9e-34
Identities = 222/1021 (21%), Positives = 408/1021 (39%), Gaps = 151/1021 (14%)
Query: 411 AWAALERKLQCLEQEKVELSRKHQEALHAPTDHRE-----LEQLRKE---VQTLRDRLPE 462
A AALE +L+ + E E + + +E + A T HR+ + LR + L ++L +
Sbjct: 896 ARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQ 955
Query: 463 MLRDKASLSQTD-------GPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQEL--- 512
+ D A L+ + +G+ + LR E+D L RE+ E L +Q+Q +
Sbjct: 956 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL 1015
Query: 513 ---CRAQGQQEELLQRLQ-EAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQV 568
C +Q L+ L E E+E + L + + REL+ + +
Sbjct: 1016 KTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEK--- 1072
Query: 569 TQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRP 628
Q + + +QR+ ES Q + +A++ AL+EQ +A S
Sbjct: 1073 -QSRARADQRITESRQVVELAVKEH------------KAEILALQQALKEQKLKAES--- 1116
Query: 629 SGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWV 688
+ L L++++ L L+ +L E+E KQRL E+ + + + Q I
Sbjct: 1117 --LSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIF--- 1171
Query: 689 NDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSA 748
++++G +AL A+ L++ R+ D +++ +Q + + +++++
Sbjct: 1172 ---RLTQGLQEAL--DRADLLKTERS-----------DLEYQLENIQVLYSHEKVKMEGT 1215
Query: 749 LEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKP 808
+ + + LQ ++ Q + ++ L K+ AL ++ + EL+ +
Sbjct: 1216 ISQQTKLIDFLQAKMDQ----PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 1271
Query: 809 SNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTAS 868
L L E SA++ +AT H P R+ + M A+ R+P + S
Sbjct: 1272 CAELEEALQKTRIELRSAREEAAHRKATDHP-HPSTPATARQQIAMSAIV-RSPE-HQPS 1328
Query: 869 TEGLPAKPGSH---TLRPRSFPS---------------------PTKCLRCTSLMLGLGR 904
L A P S + P F TKC C + GR
Sbjct: 1329 AMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTV-HFGR 1387
Query: 905 QGLGCDACGYFCHTTCAPQAPP-CPVPP------------DLLRTALGVHPETGTGTAYE 951
Q C C CH C+ P C +P D + + E + E
Sbjct: 1388 QASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLE 1447
Query: 952 GFLSVPRPSGV-RRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATP 1010
G++ VPR + ++GW R + L S++L++D + R + L L D S
Sbjct: 1448 GWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDN-EAREAGQRPVEEFELCLPDGDVSIHG 1506
Query: 1011 VL-ASDVIHAQSRDLPRIFRVTTSQLAVPPTTC----TVLLLAESEGERERWLQVL---- 1061
+ AS++ + D+P I ++ + P TTC T+ LLA S +++RW+ L
Sbjct: 1507 AVGASELANTAKADVPYILKMESH----PHTTCWPGRTLYLLAPSFPDKQRWVTALESVV 1562
Query: 1062 --GELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHL 1119
G + R +A + LK D+ L + C + +GTEEGL+ +++
Sbjct: 1563 AGGRVSREKAEADAKLLGNSLLKLEGDDRLDMN----CTLPFSDQVVLVGTEEGLYALNV 1618
Query: 1120 RSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPES--- 1176
N + V V Q+ + L+++ G ++ L + +++ +A + +P
Sbjct: 1619 LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQ-SLAQSHLPAQPDI 1677
Query: 1177 --------RGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATV 1228
+GC + AG I +C A+ +V+ + + R +E++
Sbjct: 1678 SPNIFEAVKGCHLFGAGKIENGL--CICAAMPSKVVILRYNENLSKYCIR-KEIETSEPC 1734
Query: 1229 QSLGLLGDRLCVGAAGGFAL----YPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVE 1284
+ + +G + + Y L E L P S ++ V
Sbjct: 1735 SCIHFTNYSILIGTNKFYEIDMKQYTL--EEFLDKNDHSLAPAVFAASSNSFPVSIVQVN 1792
Query: 1285 LS--LSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDV 1342
+ E+LL F G++VD GR+SR +L W P+ + Y PYL V NS++V ++
Sbjct: 1793 SAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEI 1852
Query: 1343 R 1343
+
Sbjct: 1853 Q 1853
Score = 64.3 bits (155), Expect = 9e-10
Identities = 92/422 (21%), Positives = 182/422 (43%), Gaps = 46/422 (10%)
Query: 414 ALERKLQCLEQEKVELSRKHQEALHAP--------TDHRELEQLRKEVQTLRDRLPEMLR 465
A++ K++ LEQ VELS ++ A ++ + +LR++ L + ++
Sbjct: 769 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 828
Query: 466 DKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQR 525
L + + D + EL+ RE++ L+ +EQ+L + Q EL
Sbjct: 829 QNRKLEEQLEKISHQDHSDKNRLLELETRLREVS-----LEHEEQKL-ELKRQLTELQLS 882
Query: 526 LQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQA 585
LQE + + A + AL SQL +A+ E A+ + +T + + +++ + +
Sbjct: 883 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS 942
Query: 586 KTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRL 645
T+ T E E A+L + L +QL++A SG + + QL+ E L
Sbjct: 943 CTVITDLEEQLNQLTE---DNAELNNQNFYLSKQLDEA-----SGANDEIVQLRSEVDHL 994
Query: 646 SREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSR-GYLQALATK 704
RE E +L ++++ + L + T + E Q+ D L +NDE + + +A +
Sbjct: 995 RREITEREMQLTSQKQTMEAL----KTTCTMLEEQVMD-LEALNDELLEKERQWEAWRSV 1049
Query: 705 MAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASAR-------------LELQSALEA 751
+ +E + + Q +AR Q++ S + L LQ AL+
Sbjct: 1050 LGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE 1109
Query: 752 EIRAKQGLQERLTQVQEAQLQAE---RRLQEAEKQSQALQQELAMLREELRARGPVDTKP 808
+ + L ++L +++ E R LQ+ + + L+Q L L E+ + + +D +
Sbjct: 1110 QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL--LEEQAKLQQQMDLQK 1167
Query: 809 SN 810
++
Sbjct: 1168 NH 1169
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 297 bits (761), Expect = 5e-80
Identities = 162/375 (43%), Positives = 224/375 (59%), Gaps = 46/375 (12%)
Query: 60 KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119
++K RL DDFE LKVIGRGAFGEV +V+++DTG I+AMK+L K +ML++ + A R E
Sbjct: 79 RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
Query: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
RD+LV+ D WV + Y+FQD+ LYL+M++ GGD++TLL + +D L E QFY++E
Sbjct: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISET 197
Query: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCL------------RLNTNGMVD 227
VLAI ++HQLG++HRD+KPDN+LLD GH++L+DFG C L N D
Sbjct: 198 VLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSD 257
Query: 228 SSV----------------------AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVC 265
S VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 258 FSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 312
Query: 266 AYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGR 325
YE+L G PF +E+ ETY K+MN ++ L FPP+VP + A+DLI + E R+G
Sbjct: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVP-ISEKAKDLILRFCIDSENRIGN 371
Query: 326 GGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFD--VDDDTLNHPGTLPPPSH 383
G+++ + HPFFEGVDWE + A E++ DTSNFD + D L +P +
Sbjct: 372 SGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQ---PVPNTTE 428
Query: 384 GAFSGHHLPFVGFTY 398
+ F+ +TY
Sbjct: 429 PDYKSKDWVFLNYTY 443
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 296 bits (757), Expect = 1e-79
Identities = 163/382 (42%), Positives = 226/382 (59%), Gaps = 57/382 (14%)
Query: 60 KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119
++K RL +DFE LKVIGRGAFGEV +V+++DTG ++AMK+L K +ML++ + R E
Sbjct: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
Query: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
RD+LV+ DS WV + Y+FQD+ LYL+M++ GGD++TLL + +D L E QFY+AE
Sbjct: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
Query: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRL----------NTNGMVDSS 229
VLAI S+HQLG++HRD+KPDN+LLD GH++L+DFG C L N N + S
Sbjct: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
Query: 230 V------------------------AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVC 265
VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
Query: 266 AYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGR 325
YE+L G PF +E+ ETY K+MN ++ L FPP+VP + A+DLI + C E R+G
Sbjct: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVP-ISEKAKDLILRFCCEWEHRIGA 370
Query: 326 GGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDD---------TLNHPG 376
G+++ +++ FFEGVDWE + A E++ DTSNFD + T NHP
Sbjct: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
Query: 377 TLPPPSHGAFSGHHLPFVGFTY 398
T + F+ +TY
Sbjct: 431 T-------DYKNKDWVFINYTY 445
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 221 bits (563), Expect = 4e-57
Identities = 134/364 (36%), Positives = 201/364 (55%), Gaps = 29/364 (7%)
Query: 70 DFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSR 129
DFE +K+I GA+G V +VR RDT Q FA+K ++K ++ R + ERD+L ++
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 130 WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQL 189
+V ++ +F+ +L +VM+Y GGD TLL LP ++A+ Y AE VLA+ LH
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNM-GPLPVDMARLYFAETVLALEYLHNY 484
Query: 190 GYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN-----------GMVDSSVAVGT 234
G VHRD+KPDN+L+ GHI+L DFG + + TN +D V GT
Sbjct: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVC-GT 543
Query: 235 PDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDH 294
P+YI+PE++ +G YG DWW++GV YE L G PF+ ++ E +G++++ D
Sbjct: 544 PEYIAPEVI--FRQG---YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DE 596
Query: 295 LQFPPDVPDVPASAQDLIRQLLCRQE--ERLGRGGLDDFRNHPFFEGVDWERLASSTAPY 352
+ +P +PA AQDLI +LL RQ +RLG GG + + HPFF +DW L A +
Sbjct: 597 IMWPEGDEALPADAQDLITRLL-RQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
Query: 353 IPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAW 412
+P+L DTS FD + H G+ ++ S +P F+ S S SS +
Sbjct: 656 VPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIP--QFSSCSHRFSKVYSSSEF 713
Query: 413 AALE 416
A++
Sbjct: 714 LAVQ 717
Score = 37.4 bits (85), Expect = 0.11
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 7/109 (6%)
Query: 1446 LVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPM 1505
L H + GAR +P P + GR R GP+ P + R +S G G GG +
Sbjct: 838 LSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDP---APEKSRASSSGGSG-GGSGGRV 893
Query: 1506 KRKPWTSLSSESVSCPQGSLSPATSLM---QVSERPRSLPLSPELESSP 1551
+ S S ++ GS P S + +S P S SP + SP
Sbjct: 894 PKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSP 942
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 216 bits (551), Expect = 1e-55
Identities = 215/881 (24%), Positives = 366/881 (41%), Gaps = 91/881 (10%)
Query: 67 QRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG 126
+ DFE +K+I GA+G V VR +++ Q FAMK ++K ++ R + ERD+L
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
Query: 127 DSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSL 186
++ +V +++ +F+ +L +VM+Y GGD TL+ LP ++A+ Y AE VLA+ L
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNM-GPLPVDMARMYFAETVLALEYL 495
Query: 187 HQLGYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN---GMVDSSV-------AV 232
H G VHRD+KPDN+L+ GHI+L DFG + + TN G ++
Sbjct: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555
Query: 233 GTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHE 292
GTP+YI+PE++ + +G YG DWW++G+ YE L G PF+ ++ E +G++++
Sbjct: 556 GTPEYIAPEVI--LRQG---YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS-- 608
Query: 293 DHLQFPPDVPDVPASAQDLIRQLLCRQE--ERLGRGGLDDFRNHPFFEGVDWERLASSTA 350
D + +P P AQDLI LL RQ ERLG GG + + H FF +DW L A
Sbjct: 609 DEINWPEKDEAPPPDAQDLI-TLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKA 667
Query: 351 PYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSE 410
+IP+L DTS FD + +H T + ++S SH S+
Sbjct: 668 EFIPQLESEDDTSYFDTRSEKYHHMET---EEEDDTNDEDFNVEIRQFSSCSH---RFSK 721
Query: 411 AWAALERKLQCLEQEKVELSRKHQ-------EALHAPTDHRELEQL----RKEVQTLRDR 459
+++++R Q +EK + K + E L +++ E++QL + ++ R +
Sbjct: 722 VFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHK 781
Query: 460 LPEMLRDKASLS---------QTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQ 510
L L K ++S G P PG+ + +E + E+ + + +
Sbjct: 782 LSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSSTL 841
Query: 511 ELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQ 570
+ G E L ++ E +T + ++ SS+ A QR + +S +VT+
Sbjct: 842 SV----GSFSEHLDQINGRSECVDSTDNSSKP-SSEPASHMARQRLESTEKKKISGKVTK 896
Query: 571 LQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSG 630
S+ A ++ + + P L + ++ R+ S S
Sbjct: 897 ---------SLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASA 947
Query: 631 KEEALCQLQEENRRLSREQERLEAELAQEQ-ESKQRLEGERRETESNWEAQL--ADILSW 687
+ + + + + + E +A L D+++
Sbjct: 948 SPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITH 1007
Query: 688 VNDEKVSR-------GYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEAS 740
+N E V L K++ N +T PAR + +K+R +++ + S
Sbjct: 1008 INGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPAR--RNSYKSRMVRRSKKS 1065
Query: 741 ARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRA 800
+ E + ++ L ++L + L R + + + L
Sbjct: 1066 KKKE-------SLERRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSP 1118
Query: 801 RGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPR 860
R P PS P F S S S G +RP L R
Sbjct: 1119 RSPT---PSYRSTP--DFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQR 1173
Query: 861 APTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLG 901
+ S +P P + T P P PT R S +LG
Sbjct: 1174 YRSGRRKSAGNIPLSPLART--PSPTPQPTSPQRSPSPLLG 1212
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 215 bits (547), Expect = 3e-55
Identities = 138/388 (35%), Positives = 221/388 (56%), Gaps = 27/388 (6%)
Query: 63 ELRLQRDDFEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACF-RE 118
E ++ ++FE+LKV+G GA+G+V +VR+ D G+++AMK+L K +++RA+T R
Sbjct: 25 EEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT 84
Query: 119 ERDVL-VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177
ER VL + + ++ TLHYAFQ + L+L++DY +GG++ T L + + E+ + Y
Sbjct: 85 ERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEV-RVYGG 143
Query: 178 EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237
E+VLA+ LH+LG ++RD+K +NVLLD GHI L DFG T + GT +Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 238 ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297
++PEI+++ K +G DWWSLG+ +ELL G +PF E T ++
Sbjct: 204 MAPEIIRS----KTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS- 258
Query: 298 PPDVPDVPASAQDLIRQLLCRQ-EERLGRG--GLDDFRNHPFFEGVDWERLASS--TAPY 352
PP P + AQDL+++LLC+ ++RLG G G + RNHPFF+G+DW LA+ AP+
Sbjct: 259 PPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPF 318
Query: 353 IPELRGPMDTSNFDVD----DDTLNHPGTLPPPSHGAFSGHHL--PFVGFTY-----TSG 401
P++R +D NF + + + PG+ PP F G+ P + F + T G
Sbjct: 319 RPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDG 378
Query: 402 SHSPESSSEAWAALERKLQCLEQEKVEL 429
+P + A + ++Q +++L
Sbjct: 379 LEAPGAGDRPGRAAVARSAMMQQYELDL 406
Score = 90.5 bits (223), Expect = 1e-17
Identities = 68/208 (32%), Positives = 102/208 (49%), Gaps = 15/208 (7%)
Query: 77 IGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHY 136
+G+G+F RQR +GQ FA+K+L + R E RE + + V LH
Sbjct: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSR-----RLEANTQREVAALRLCQSHPNVVNLHE 465
Query: 137 AFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ-LGYVHRD 195
D+ + YLV++ GG+LL + + E +Q L +V A+ +H+ G VHRD
Sbjct: 466 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQI-LRSLVSAVSFMHEEAGVVHRD 524
Query: 196 VKPDNVLL--DVNGH-IRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGH 252
+KP+N+L D G +++ DFG + V T Y +PE+L ++G
Sbjct: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA--QQG--- 579
Query: 253 YGPQCDWWSLGVCAYELLFGETPFYAES 280
Y CD WSLGV Y +L G+ PF S
Sbjct: 580 YDESCDLWSLGVILYMMLSGQVPFQGAS 607
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 214 bits (546), Expect = 4e-55
Identities = 120/321 (37%), Positives = 182/321 (56%), Gaps = 23/321 (7%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDS 128
+DFE +K+I GA+G V +VR + T Q FAMK ++K ++ R + ERD+L ++
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 129 RWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ 188
+V ++ +F + +L +VM+Y GGD TLL LP ++ + Y AE VLA+ LH
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNI-GALPVDMVRLYFAETVLALEYLHN 628
Query: 189 LGYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN---GMVDSSV-------AVGT 234
G VHRD+KPDN+L+ GHI+L DFG + L TN G ++ GT
Sbjct: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
Query: 235 PDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDH 294
P+YI+PE++ + +G YG DWW++G+ YE L G PF+ ++ E +G++++ D
Sbjct: 689 PEYIAPEVI--LRQG---YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--DE 741
Query: 295 LQFPPDVPDVPASAQDLIRQLLCRQE-ERLGRGGLDDFRNHPFFEGVDWERLASSTAPYI 353
+ +P +P AQDL +LL + ERLG G + + HPFF G+DW L A +I
Sbjct: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 801
Query: 354 PELRGPMDTSNFDVDDDTLNH 374
P+L DTS FD + +H
Sbjct: 802 PQLESEDDTSYFDTRSERYHH 822
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 213 bits (541), Expect = 2e-54
Identities = 130/341 (38%), Positives = 203/341 (59%), Gaps = 20/341 (5%)
Query: 63 ELRLQRDDFEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACF-RE 118
E ++ ++FE+LKV+G GA+G+V +VR+ D G+++AMK+L K +++RA+T R
Sbjct: 25 EEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT 84
Query: 119 ERDVL-VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177
ER VL + + ++ TLHYAFQ + L+L++DY +GG++ T L + + E+ + Y
Sbjct: 85 ERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEV-RVYGG 143
Query: 178 EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237
E+VLA+ LH+LG ++RD+K +NVLLD GHI L DFG T + GT +Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 238 ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297
++PEI+++ K +G DWWSLG+ +ELL G +PF E T ++
Sbjct: 204 MAPEIIRS----KTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCS- 258
Query: 298 PPDVPDVPASAQDLIRQLLCRQ-EERLGRG--GLDDFRNHPFFEGVDWERLASS--TAPY 352
PP P + AQDL+++LLC+ ++RLG G G + RNHPFF+G+DW LA+ AP+
Sbjct: 259 PPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPF 318
Query: 353 IPELRGPMDTSNFDVD----DDTLNHPGTLPPPSHGAFSGH 389
P++R +D NF + + + PG+ PP F G+
Sbjct: 319 RPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGY 359
Score = 90.5 bits (223), Expect = 1e-17
Identities = 68/208 (32%), Positives = 102/208 (49%), Gaps = 15/208 (7%)
Query: 77 IGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHY 136
+G+G+F RQR +GQ FA+K+L + R E RE + + V LH
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSR-----RLEANTQREVAALRLCQSHPNVVNLHE 471
Query: 137 AFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ-LGYVHRD 195
D+ + YLV++ GG+LL + + E +Q L +V A+ +H+ G VHRD
Sbjct: 472 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQI-LRSLVSAVSFMHEEAGVVHRD 530
Query: 196 VKPDNVLL--DVNGH-IRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGH 252
+KP+N+L D G +++ DFG + V T Y +PE+L ++G
Sbjct: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA--QQG--- 585
Query: 253 YGPQCDWWSLGVCAYELLFGETPFYAES 280
Y CD WSLGV Y +L G+ PF S
Sbjct: 586 YDESCDLWSLGVILYMMLSGQVPFQGAS 613
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 210 bits (535), Expect = 7e-54
Identities = 122/321 (38%), Positives = 178/321 (55%), Gaps = 23/321 (7%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDS 128
+DF+ +K+I GA+G V +VR RDT Q FAMK ++K ++ R + ERD+L ++
Sbjct: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
Query: 129 RWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ 188
+V + +F+ +L +VM+Y GGD TLL LP E+A+ Y AE VLA+ LH
Sbjct: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNI-GALPVEMARMYFAETVLALEYLHN 490
Query: 189 LGYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN---GMVDSSV-------AVGT 234
G VHRD+KPDN+L+ GHI+L DFG + L TN G ++ GT
Sbjct: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
Query: 235 PDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDH 294
P+YI+PE++ + +G YG DWW++G+ YE L G PF+ ++ E +G++++ D
Sbjct: 551 PEYIAPEVI--LRQG---YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--DD 603
Query: 295 LQFPPDVPDVPASAQDLIRQLL-CRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYI 353
+ +P +P AQ LI LL RLG GG + + H FF +DW L A +I
Sbjct: 604 ILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFI 663
Query: 354 PELRGPMDTSNFDVDDDTLNH 374
P L DTS FD D +H
Sbjct: 664 PHLESEDDTSYFDTRSDRYHH 684
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 207 bits (527), Expect = 6e-53
Identities = 131/338 (38%), Positives = 199/338 (58%), Gaps = 26/338 (7%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACF-REERDVLV 124
++FE+LKV+G GA+G+V +VR+ DTG+++AMK+L K ++++A+T R ER VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 125 K-GDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183
S ++ TLHYAFQ E L+L++DY GG+L T LS+ E R Q Y+ E+VLA+
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLAL 165
Query: 184 HSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEIL 243
LH+LG ++RD+K +N+LLD NGH+ L DFG + + GT +Y++P+I+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225
Query: 244 QAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAE----SLVETYGKIMNHEDHLQFPP 299
+ + G + DWWSLGV YELL G +PF + S E +I+ E PP
Sbjct: 226 RGGDSG---HDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE-----PP 277
Query: 300 DVPDVPASAQDLIRQLLCRQ-EERLGRG--GLDDFRNHPFFEGVDWERLASS--TAPYIP 354
++ A A+DLI++LL + ++RLG G D+ + H FF+ ++W+ LA+ AP+ P
Sbjct: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Query: 355 ELRGPMDTSNFD---VDDDTLNHPGTLPPPSHGAFSGH 389
+R +D SNF + D P LP S F G+
Sbjct: 338 VIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGY 375
Score = 53.9 bits (128), Expect = 1e-06
Identities = 34/125 (27%), Positives = 62/125 (49%), Gaps = 6/125 (4%)
Query: 75 KVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTL 134
K +G G+F + + Q FA+K++ K R E +E + + + L
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISK-----RMEANTQKEITALKLCEGHPNIVKL 484
Query: 135 HYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHR 194
H F D+ + +LVM+ GG+L + + + E A + + ++V A+ +H +G VHR
Sbjct: 485 HEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE-ASYIMRKLVSAVSHMHDVGVVHR 543
Query: 195 DVKPD 199
D+KP+
Sbjct: 544 DLKPE 548
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 207 bits (527), Expect = 6e-53
Identities = 131/338 (38%), Positives = 199/338 (58%), Gaps = 26/338 (7%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACF-REERDVLV 124
++FE+LKV+G GA+G+V +VR+ DTG+++AMK+L K ++++A+T R ER VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 125 K-GDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183
S ++ TLHYAFQ E L+L++DY GG+L T LS+ E R Q Y+ E+VLA+
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLAL 165
Query: 184 HSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEIL 243
LH+LG ++RD+K +N+LLD NGH+ L DFG + + GT +Y++P+I+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225
Query: 244 QAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAE----SLVETYGKIMNHEDHLQFPP 299
+ + G + DWWSLGV YELL G +PF + S E +I+ E PP
Sbjct: 226 RGGDSG---HDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE-----PP 277
Query: 300 DVPDVPASAQDLIRQLLCRQ-EERLGRG--GLDDFRNHPFFEGVDWERLASS--TAPYIP 354
++ A A+DLI++LL + ++RLG G D+ + H FF+ ++W+ LA+ AP+ P
Sbjct: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Query: 355 ELRGPMDTSNFD---VDDDTLNHPGTLPPPSHGAFSGH 389
+R +D SNF + D P LP S F G+
Sbjct: 338 VIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGY 375
Score = 89.7 bits (221), Expect = 2e-17
Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 26/266 (9%)
Query: 75 KVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTL 134
K +G G+F + + Q FA+K++ K R E +E + + + L
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISK-----RMEANTQKEITALKLCEGHPNIVKL 484
Query: 135 HYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHR 194
H F D+ + +LVM+ GG+L + + + E A + + ++V A+ +H +G VHR
Sbjct: 485 HEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE-ASYIMRKLVSAVSHMHDVGVVHR 543
Query: 195 DVKPDNVLL---DVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKG 251
D+KP+N+L + N I++ DFG RL T Y +PE+L +
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFA-RLKPPDNQPLKTPCFTLHYAAPELL-----NQN 597
Query: 252 HYGPQCDWWSLGVCAYELLFGETPFYAE-------SLVETYGKIMNHEDHLQFPPDV-PD 303
Y CD WSLGV Y +L G+ PF + S VE KI + F + +
Sbjct: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGD--FSFEGEAWKN 655
Query: 304 VPASAQDLIRQLL-CRQEERLGRGGL 328
V A+DLI+ LL +RL GL
Sbjct: 656 VSQEAKDLIQGLLTVDPNKRLKMSGL 681
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 201 bits (510), Expect = 6e-51
Identities = 138/362 (38%), Positives = 199/362 (54%), Gaps = 30/362 (8%)
Query: 56 PFVSKVKELRLQRD--DFEILKVIGRGAFGEVTVVRQR---DTGQIFAMKMLHKWEMLKR 110
P VKE + D FE+LKV+G+G+FG+V +VR++ D GQ++AMK+L K LK
Sbjct: 56 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK-ASLKV 114
Query: 111 AETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE 170
+ + ERD+LV+ + ++ LHYAFQ E LYL++D+ GGD+ T LS+ E E
Sbjct: 115 RDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173
Query: 171 LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSV 230
+FYLAE+ LA+ LHQLG V+RD+KP+N+LLD GHI+L DFG L+ +
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG----LSKESVDQEKK 229
Query: 231 A---VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGK 287
A GT +Y++PE++ +GH DWWS GV +E+L G PF + ET
Sbjct: 230 AYSFCGTVEYMAPEVVNR----RGH-SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNM 284
Query: 288 IMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQ-EERLGRGGLDDFRNHPFFEGVDWERLA 346
I+ + L P + A AQ L+R L R RLG G+++ + H FF +DW++L
Sbjct: 285 ILKAK--LGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLY 339
Query: 347 SSTA--PYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHS 404
P+ P P DT FD + T P P A + H F GF++ + S +
Sbjct: 340 KREVQPPFKPASGKPDDTFCFD-PEFTAKTP--KDSPGLPASANAHQLFKGFSFVATSIA 396
Query: 405 PE 406
E
Sbjct: 397 EE 398
Score = 84.3 bits (207), Expect = 8e-16
Identities = 71/215 (33%), Positives = 111/215 (51%), Gaps = 27/215 (12%)
Query: 71 FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVK-GDSR 129
+E+ + IG G++ T FA+K++ K KR + EE ++L++ G
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDPS----EEIEILMRYGQHP 478
Query: 130 WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSR---FEDRLPPELAQFYLAEMVLAIHSL 186
+ TL F D Y+YLV D GG+LL + + F +R ++ L + + L
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVDYL 534
Query: 187 HQLGYVHRDVKPDNVL-LDVNGH---IRLADFGSCLRLN-TNGMVDSSVAVGTPDYISPE 241
H G VHRD+KP N+L +D + IR+ DFG +L NG++ + T ++++PE
Sbjct: 535 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY--TANFVAPE 592
Query: 242 ILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF 276
+L M++G Y CD WSLGV Y +L G TPF
Sbjct: 593 VL--MQQG---YDAACDIWSLGVLFYTMLAGYTPF 622
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 201 bits (510), Expect = 6e-51
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 28/350 (8%)
Query: 71 FEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGD 127
FE+LKV+G+G++G+V +VR+ D GQ++AMK+L K LK + + ERD+L + +
Sbjct: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 125
Query: 128 SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLH 187
++ LHYAFQ E LYL++D+ GGDL T LS+ E E +FYLAE+ LA+ LH
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 184
Query: 188 QLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAME 247
LG ++RD+KP+N+LLD GHI++ DFG + S GT +Y++PE++
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFC-GTIEYMAPEVVNR-- 241
Query: 248 EGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPAS 307
+GH DWWS GV +E+L G PF + ET I+ + L P +
Sbjct: 242 --RGH-TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK--LGMP---QFLSGE 293
Query: 308 AQDLIRQLLCRQE-ERLGRG--GLDDFRNHPFFEGVDWERL--ASSTAPYIPELRGPMDT 362
AQ L+R L R RLG G G+++ + HPFF +DW L P+ P + P DT
Sbjct: 294 AQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDT 353
Query: 363 SNFDVDDDTLNHPGTLP--PPSHGAFSGHHLPFVGFTYTSGSHSPESSSE 410
+FD + T P P PPS A HHL F GF++ + S E S +
Sbjct: 354 FHFD-PEFTARTPTDSPGVPPSANA---HHL-FRGFSFVASSLIQEPSQQ 398
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/217 (31%), Positives = 113/217 (52%), Gaps = 27/217 (12%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVK-GD 127
D +EI + IG G++ + T +A+K++ K KR + EE ++L++ G
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS----EEIEILLRYGQ 473
Query: 128 SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSR---FEDRLPPELAQFYLAEMVLAIH 184
+ TL + D +++YLVM+ GG+LL + R F +R ++ L + +
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV----LCTITKTMD 529
Query: 185 SLHQLGYVHRDVKPDNVLL-DVNGH---IRLADFGSCLRLNT-NGMVDSSVAVGTPDYIS 239
LH G VHRD+KP N+L D +G IR+ DFG +L NG++ + T ++++
Sbjct: 530 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY--TANFVA 587
Query: 240 PEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF 276
PE+L+ + Y CD WSLG+ Y +L G TPF
Sbjct: 588 PEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPF 619
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 201 bits (510), Expect = 6e-51
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 28/350 (8%)
Query: 71 FEILKVIGRGAFGEVTVVRQ---RDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGD 127
FE+LKV+G+G++G+V +VR+ D GQ++AMK+L K LK + + ERD+L + +
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 117
Query: 128 SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLH 187
++ LHYAFQ E LYL++D+ GGDL T LS+ E E +FYLAE+ LA+ LH
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 176
Query: 188 QLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAME 247
LG ++RD+KP+N+LLD GHI++ DFG + S GT +Y++PE++
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFC-GTIEYMAPEVVNR-- 233
Query: 248 EGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPAS 307
+GH DWWS GV +E+L G PF + ET I+ + L P +
Sbjct: 234 --RGH-TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK--LGMP---QFLSGE 285
Query: 308 AQDLIRQLLCRQE-ERLGRG--GLDDFRNHPFFEGVDWERL--ASSTAPYIPELRGPMDT 362
AQ L+R L R RLG G G+++ + HPFF +DW L P+ P + P DT
Sbjct: 286 AQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDT 345
Query: 363 SNFDVDDDTLNHPGTLP--PPSHGAFSGHHLPFVGFTYTSGSHSPESSSE 410
+FD + T P P PPS A HHL F GF++ + S E S +
Sbjct: 346 FHFD-PEFTARTPTDSPGVPPSANA---HHL-FRGFSFVASSLIQEPSQQ 390
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/217 (31%), Positives = 113/217 (52%), Gaps = 27/217 (12%)
Query: 69 DDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVK-GD 127
D +EI + IG G++ + T +A+K++ K KR + EE ++L++ G
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS----EEIEILLRYGQ 465
Query: 128 SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSR---FEDRLPPELAQFYLAEMVLAIH 184
+ TL + D +++YLVM+ GG+LL + R F +R ++ L + +
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV----LCTITKTMD 521
Query: 185 SLHQLGYVHRDVKPDNVLL-DVNGH---IRLADFGSCLRLNT-NGMVDSSVAVGTPDYIS 239
LH G VHRD+KP N+L D +G IR+ DFG +L NG++ + T ++++
Sbjct: 522 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY--TANFVA 579
Query: 240 PEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF 276
PE+L+ + Y CD WSLG+ Y +L G TPF
Sbjct: 580 PEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPF 611
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 199 bits (507), Expect = 1e-50
Identities = 123/339 (36%), Positives = 187/339 (55%), Gaps = 19/339 (5%)
Query: 67 QRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG 126
Q DF+ LKVIG+G +G+V + +++ G +A+K+L K +LK+ E + ER VL+K
Sbjct: 31 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN 90
Query: 127 DSR-WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHS 185
++ L Y+FQ E LY V+DY GG+L L R L P A+FY AE+ AI
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPR-ARFYAAEVASAIGY 149
Query: 186 LHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQA 245
LH L ++RD+KP+N+LLD GH+ L DFG C + +S GTP+Y++PE+L+
Sbjct: 150 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLC-KEGVEPEDTTSTFCGTPEYLAPEVLR- 207
Query: 246 MEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVP 305
K Y DWW LG YE+L G PFY++ + + Y I++ LQ P
Sbjct: 208 ----KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP--LQIP---GGRT 258
Query: 306 ASAQDLIRQLLCR-QEERLG-RGGLDDFRNHPFFEGVDWERLASS--TAPYIPELRGPMD 361
+A DL++ LL + Q +RLG + + +NH FF ++W+ L T P+ P + GP D
Sbjct: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
Query: 362 TSNFDVD--DDTLNHPGTLPPPSHGAFSGHHLPFVGFTY 398
+FD + + ++ P + + SG F+GF+Y
Sbjct: 319 LKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 199 bits (507), Expect = 1e-50
Identities = 123/339 (36%), Positives = 187/339 (55%), Gaps = 19/339 (5%)
Query: 67 QRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG 126
Q DF+ LKVIG+G +G+V + +++ G +A+K+L K +LK+ E + ER VL+K
Sbjct: 91 QPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKN 150
Query: 127 DSR-WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHS 185
++ L Y+FQ E LY V+DY GG+L L R L P A+FY AE+ AI
Sbjct: 151 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPR-ARFYAAEVASAIGY 209
Query: 186 LHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQA 245
LH L ++RD+KP+N+LLD GH+ L DFG C + +S GTP+Y++PE+L+
Sbjct: 210 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLC-KEGVEPEDTTSTFCGTPEYLAPEVLR- 267
Query: 246 MEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVP 305
K Y DWW LG YE+L G PFY++ + + Y I++ LQ P
Sbjct: 268 ----KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP--LQIP---GGRT 318
Query: 306 ASAQDLIRQLLCR-QEERLG-RGGLDDFRNHPFFEGVDWERLASS--TAPYIPELRGPMD 361
+A DL++ LL + Q +RLG + + +NH FF ++W+ L T P+ P + GP D
Sbjct: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
Query: 362 TSNFDVD--DDTLNHPGTLPPPSHGAFSGHHLPFVGFTY 398
+FD + + ++ P + + SG F+GF+Y
Sbjct: 379 LKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 198 bits (504), Expect = 3e-50
Identities = 127/354 (35%), Positives = 193/354 (54%), Gaps = 32/354 (9%)
Query: 65 RLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL- 123
RL D+FE ++V+G+G+FG+V + R ++TG ++A+K+L K +L+ + C E+ +L
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183
+ + ++T L FQ + L+ VM++ GGDL+ + + R A+FY AE++ A+
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR-RFDEARARFYAAEIISAL 467
Query: 184 HSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEIL 243
LH G ++RD+K DNVLLD GH +LADFG C NG V ++ GTPDYI+PEIL
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG-VTTATFCGTPDYIAPEIL 526
Query: 244 QAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPD 303
Q M YGP DWW++GV YE+L G PF AE+ + + I+N D + +P + +
Sbjct: 527 QEM-----LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYPTWLHE 579
Query: 304 VPASAQDLIRQLLCRQEE-RLG---RGGLDDFRNHPFFEGVDWERL--ASSTAPYIPELR 357
A +++ + + RLG +GG HPFF+ +DW +L P+ P ++
Sbjct: 580 ---DATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIK 636
Query: 358 GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLP------FVGFTYTSGSHSP 405
D SNF D D + L P G HLP F F+Y S P
Sbjct: 637 SREDVSNF--DPDFIKEEPVLTPIDEG-----HLPMINQDEFRNFSYVSPELQP 683
Score = 40.0 bits (92), Expect = 0.018
Identities = 25/69 (36%), Positives = 33/69 (47%), Gaps = 2/69 (2%)
Query: 879 HTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTC-APQAPPCPV-PPDLLRT 936
H ++ PT C C SL+ G+ RQGL C C H C A AP C V +L +T
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305
Query: 937 ALGVHPETG 945
G+ + G
Sbjct: 306 LAGMGLQPG 314
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 198 bits (504), Expect = 3e-50
Identities = 120/304 (39%), Positives = 173/304 (56%), Gaps = 21/304 (6%)
Query: 70 DFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSR 129
DF LKVIG+G+FG+V + R + +A+K+L K +LK+ E ER+VL+K
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 130 -WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ 188
++ LH++FQ + LY V+DY GG+L L R L P A+FY AE+ A+ LH
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR-ARFYAAEIASALGYLHS 215
Query: 189 LGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEE 248
L V+RD+KP+N+LLD GHI L DFG C + N +S GTP+Y++PE+L
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLH---- 270
Query: 249 GKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASA 308
K Y DWW LG YE+L+G PFY+ + E Y I+N L+ P++ SA
Sbjct: 271 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 324
Query: 309 QDLIRQLLCRQEERLGR-GGLDDF---RNHPFFEGVDWERLASS--TAPYIPELRGPMDT 362
+ L+ LL Q++R R G DDF ++H FF ++W+ L + T P+ P + GP D
Sbjct: 325 RHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 382
Query: 363 SNFD 366
+FD
Sbjct: 383 RHFD 386
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 198 bits (504), Expect = 3e-50
Identities = 120/304 (39%), Positives = 173/304 (56%), Gaps = 21/304 (6%)
Query: 70 DFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSR 129
DF LKVIG+G+FG+V + R + +A+K+L K +LK+ E ER+VL+K
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 130 -WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ 188
++ LH++FQ + LY V+DY GG+L L R L P A+FY AE+ A+ LH
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR-ARFYAAEIASALGYLHS 229
Query: 189 LGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEE 248
L V+RD+KP+N+LLD GHI L DFG C + N +S GTP+Y++PE+L
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLH---- 284
Query: 249 GKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASA 308
K Y DWW LG YE+L+G PFY+ + E Y I+N L+ P++ SA
Sbjct: 285 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 338
Query: 309 QDLIRQLLCRQEERLGR-GGLDDF---RNHPFFEGVDWERLASS--TAPYIPELRGPMDT 362
+ L+ LL Q++R R G DDF ++H FF ++W+ L + T P+ P + GP D
Sbjct: 339 RHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 396
Query: 363 SNFD 366
+FD
Sbjct: 397 RHFD 400
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 198 bits (504), Expect = 3e-50
Identities = 120/304 (39%), Positives = 173/304 (56%), Gaps = 21/304 (6%)
Query: 70 DFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSR 129
DF LKVIG+G+FG+V + R + +A+K+L K +LK+ E ER+VL+K
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 130 -WVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQ 188
++ LH++FQ + LY V+DY GG+L L R L P A+FY AE+ A+ LH
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR-ARFYAAEIASALGYLHS 243
Query: 189 LGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEE 248
L V+RD+KP+N+LLD GHI L DFG C + N +S GTP+Y++PE+L
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLH---- 298
Query: 249 GKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASA 308
K Y DWW LG YE+L+G PFY+ + E Y I+N L+ P++ SA
Sbjct: 299 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 352
Query: 309 QDLIRQLLCRQEERLGR-GGLDDF---RNHPFFEGVDWERLASS--TAPYIPELRGPMDT 362
+ L+ LL Q++R R G DDF ++H FF ++W+ L + T P+ P + GP D
Sbjct: 353 RHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 410
Query: 363 SNFD 366
+FD
Sbjct: 411 RHFD 414
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,935,087
Number of Sequences: 37866
Number of extensions: 3451440
Number of successful extensions: 32960
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 898
Number of HSP's successfully gapped in prelim test: 1359
Number of HSP's that attempted gapping in prelim test: 15694
Number of HSP's gapped (non-prelim): 8384
length of query: 1551
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1435
effective length of database: 13,855,062
effective search space: 19882013970
effective search space used: 19882013970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.