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Search of human proteins with 156231353
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo
sapiens]
(1332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 2665 0.0
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 2649 0.0
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 905 0.0
gi|134254450 patched isoform S [Homo sapiens] 126 1e-28
gi|134254435 patched isoform S [Homo sapiens] 126 1e-28
gi|134254468 patched isoform S [Homo sapiens] 126 1e-28
gi|134254452 patched isoform S [Homo sapiens] 126 1e-28
gi|134254432 patched isoform L' [Homo sapiens] 126 1e-28
gi|134254466 patched isoform M [Homo sapiens] 126 1e-28
gi|134254446 patched isoform L [Homo sapiens] 126 1e-28
gi|52145305 patched 2 [Homo sapiens] 110 9e-24
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 103 1e-21
gi|194018513 patched domain containing 3 [Homo sapiens] 99 2e-20
gi|148271104 patched domain containing 1 [Homo sapiens] 90 2e-17
gi|66932902 SREBF chaperone protein [Homo sapiens] 74 7e-13
gi|149274653 patched domain containing 2 [Homo sapiens] 49 2e-05
gi|25121980 dispatched B [Homo sapiens] 49 3e-05
gi|25952134 dispatched A [Homo sapiens] 41 0.007
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 33 1.8
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c... 32 3.1
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c... 32 3.1
gi|14550407 complement component 2 isoform 1 preproprotein [Homo... 32 3.1
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [... 32 3.1
gi|27437051 colony stimulating factor 3 isoform c [Homo sapiens] 32 4.1
gi|27437049 colony stimulating factor 3 isoform b precursor [Hom... 32 4.1
gi|105990532 apolipoprotein B precursor [Homo sapiens] 31 9.1
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 31 9.1
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 31 9.1
gi|194473684 chondroitin sulfate N-acetylgalactosaminyltransfera... 31 9.1
gi|194473683 chondroitin sulfate N-acetylgalactosaminyltransfera... 31 9.1
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 2665 bits (6909), Expect = 0.0
Identities = 1332/1332 (100%), Positives = 1332/1332 (100%)
Query: 1 MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN 60
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN
Sbjct: 1 MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN 60
Query: 61 TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF 120
TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF
Sbjct: 61 TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF 120
Query: 121 VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA 180
VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA
Sbjct: 121 VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA 180
Query: 181 ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV 240
ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV
Sbjct: 181 ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV 240
Query: 241 ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI 300
ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
Sbjct: 241 ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI 300
Query: 301 LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV 360
LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV
Sbjct: 301 LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV 360
Query: 361 IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY 420
IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY
Sbjct: 361 IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY 420
Query: 421 RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT 480
RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT
Sbjct: 421 RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT 480
Query: 481 SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL 540
SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL
Sbjct: 481 SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL 540
Query: 541 SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM 600
SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
Sbjct: 541 SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM 600
Query: 601 RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV 660
RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV
Sbjct: 601 RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV 660
Query: 661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE 720
MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE
Sbjct: 661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE 720
Query: 721 YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV 780
YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV
Sbjct: 721 YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV 780
Query: 781 ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL 840
ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL
Sbjct: 781 ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL 840
Query: 841 LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV 900
LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
Sbjct: 841 LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV 900
Query: 901 YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW 960
YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
Sbjct: 901 YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW 960
Query: 961 LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP
Sbjct: 961 LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
Query: 1021 NIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
NIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL
Sbjct: 1021 NIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL
Sbjct: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLER 1200
NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLER
Sbjct: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLER 1200
Query: 1201 AKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPV 1260
AKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPV
Sbjct: 1201 AKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPV 1260
Query: 1261 ILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGA 1320
ILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGA
Sbjct: 1261 ILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGA 1320
Query: 1321 ISNFLPNNGRQF 1332
ISNFLPNNGRQF
Sbjct: 1321 ISNFLPNNGRQF 1332
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapiens]
Length = 1359
Score = 2649 bits (6867), Expect = 0.0
Identities = 1331/1359 (97%), Positives = 1331/1359 (97%), Gaps = 27/1359 (1%)
Query: 1 MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN 60
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN
Sbjct: 1 MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN 60
Query: 61 TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF 120
TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF
Sbjct: 61 TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF 120
Query: 121 VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA 180
VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA
Sbjct: 121 VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA 180
Query: 181 ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV 240
ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV
Sbjct: 181 ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV 240
Query: 241 ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI 300
ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
Sbjct: 241 ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI 300
Query: 301 LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV 360
LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV
Sbjct: 301 LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV 360
Query: 361 IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY 420
IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY
Sbjct: 361 IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY 420
Query: 421 RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT 480
RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT
Sbjct: 421 RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT 480
Query: 481 SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL 540
SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL
Sbjct: 481 SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL 540
Query: 541 SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM 600
SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
Sbjct: 541 SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM 600
Query: 601 RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV 660
RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV
Sbjct: 601 RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV 660
Query: 661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE 720
MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE
Sbjct: 661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE 720
Query: 721 YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV 780
YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV
Sbjct: 721 YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV 780
Query: 781 ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL 840
ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL
Sbjct: 781 ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL 840
Query: 841 LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV 900
LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
Sbjct: 841 LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV 900
Query: 901 YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW 960
YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
Sbjct: 901 YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW 960
Query: 961 LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP
Sbjct: 961 LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
Query: 1021 NIKCPKGGLAAYSTSVNLTSDGQVL---------------------------ASRFMAYH 1053
NIKCPKGGLAAYSTSVNLTSDGQVL SRFMAYH
Sbjct: 1021 NIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYH 1080
Query: 1054 KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL 1113
KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL
Sbjct: 1081 KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL 1140
Query: 1114 FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS 1173
FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS
Sbjct: 1141 FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS 1200
Query: 1174 AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ 1233
AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ
Sbjct: 1201 AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ 1260
Query: 1234 LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP 1293
LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP
Sbjct: 1261 LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP 1320
Query: 1294 NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF 1332
NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF
Sbjct: 1321 NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF 1359
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 905 bits (2338), Expect = 0.0
Identities = 517/1290 (40%), Positives = 755/1290 (58%), Gaps = 59/1290 (4%)
Query: 7 RGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKI 66
RG L LLL L ++ ++ C +Y ECG +C + P + +
Sbjct: 4 RGLALGLLLLLLCPAQVFSQS-----CVWYGECG-------IAYGDKRYNCEYSGPPKPL 51
Query: 67 TGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCH 126
D L+Q++CP + G N CC +QL +L+ +L + L+RCP+C N +NL C
Sbjct: 52 PKDGYDLVQELCPGFFFG-NVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCE 110
Query: 127 NTCSPNQSLFINVTR----VAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAAT 182
TCSP QS F+NVT V + V + + SFA Y++C V P++
Sbjct: 111 LTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSND 170
Query: 183 LAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVAR 242
A+G +CG A CNA W+ + + NG AP IT + G++P+N
Sbjct: 171 KALGLLCGKDADA-CNATNWIEYMFNKDNGQAPFTITPVFSD---FPVHGMEPMNNATKG 226
Query: 243 CNESQGDDVATCSCQDCAASCPAIARPQ---------ALDSTFYLGQMPGSLVLIIILCS 293
C+ES + A CSCQDC+ C +P LD+ + + + L++ +
Sbjct: 227 CDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGA 286
Query: 294 VFAVVTILLVGF--RVAPARDK---SKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWV 348
FAV F P S K S D +S + L + F WG++
Sbjct: 287 FFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFC 346
Query: 349 ASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTN 408
P ++ S++ + A ++GLVF +TT+PV+LWSAP+SQAR EK + DQHFGPFFRT
Sbjct: 347 VRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTE 406
Query: 409 QVILTAPNRSSYRYDSLLLGPK-NFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISL 467
Q+I+ AP + Y G F LD+ +L ++L+LQ + ++ + ++L
Sbjct: 407 QLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTL 464
Query: 468 QDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCAN 527
QDIC APL+P NT+ C I S+L YFQN+ ++L D+ HFLYC
Sbjct: 465 QDICLAPLSPYNTN---CTILSVLNYFQNSHSVLDHKKGDDFF---VYADYHTHFLYCVR 518
Query: 528 APLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLA 587
AP + D + L C+ +G PVFP+L +GGY ++Y+ A AL++TF +NNY +L
Sbjct: 519 APASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQ 578
Query: 588 QAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYI 647
+A+ WE+ F+ ++ ++ ++F AERS+EDE+NR + D+ SY ++FLYI
Sbjct: 579 RAQAWEKEFINFVKNYKNPN---LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYI 635
Query: 648 SLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVL 707
SLALG S R++VDSK +LG+ G+ +VL +V ++G FSY+G+ +L++++V+PFLVL
Sbjct: 636 SLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVL 695
Query: 708 SVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMP 767
+VG DNIFI V YQR R GE + +GR LG VAPSM L S SE + FFLGAL+ MP
Sbjct: 696 AVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMP 755
Query: 768 AVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQ-GEG 826
AV TF+L +GLAV +DFLLQ++ FV+LL LD KRQE +RLD+ CCV+ E Q E
Sbjct: 756 AVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASES 815
Query: 827 LLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDY 886
L FF+ +Y+P LL R +V+ +F+ + S+ + + +GLDQ L++P DSY++DY
Sbjct: 816 CLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDY 875
Query: 887 FLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYL 946
F +++Y G PVYFV G++++S G N +C GCNN S Q+I A + + +
Sbjct: 876 FKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRI 935
Query: 947 AIPASSWVDDFIDWLTP-SSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSIT-MGSVRPS 1004
SSW+DD+ DW+ P SSCCR+ D+FC ++V C++ C +T G RP
Sbjct: 936 GFAPSSWIDDYFDWVKPQSSCCRV---DNITDQFCNASVVDPACVR-CRPLTPEGKQRPQ 991
Query: 1005 VEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN--LTSDGQVLASRFMAYHKPLKNSQDY 1062
F ++LP FL+D PN KC KGG AAYS++VN L +V A+ FM YH L+ S D+
Sbjct: 992 GGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADF 1051
Query: 1063 TEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVP 1122
+AL+ AR +A+N+T + + G+ A+ VFPY++ VFYEQYLTI+ + +F L + L
Sbjct: 1052 IDALKKARLIASNVT-ETMGINGS--AYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGA 1108
Query: 1123 TFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFV 1182
F V+ +LLG +L S ++ +I M+LV+ G M LWGIS NAVSL+NLV + G+SVEF
Sbjct: 1109 IFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFC 1168
Query: 1183 SHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRL 1242
SHITR+F +S K + +ERA+EA MGS+VF+G+ +T GI+VL AK+Q+ QIF+FR+
Sbjct: 1169 SHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRM 1228
Query: 1243 NLLITLLGLLHGLVFLPVILSYVGPDVNPA 1272
L + LLG HGL+FLPV+LSY+GP VN A
Sbjct: 1229 YLAMVLLGATHGLIFLPVLLSYIGPSVNKA 1258
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 641 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 680
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 681 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 740
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 741 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 794
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 795 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 852
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 853 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 905
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 906 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 961
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 962 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1078
Query: 1314 SIKG 1317
++ G
Sbjct: 1079 TVSG 1082
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 641 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 680
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 681 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 740
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 741 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 794
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 795 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 852
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 853 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 905
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 906 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 961
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 962 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1078
Query: 1314 SIKG 1317
++ G
Sbjct: 1079 TVSG 1082
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 641 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 680
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 681 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 740
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 741 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 794
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 795 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 852
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 853 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 905
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 906 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 961
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 962 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1078
Query: 1314 SIKG 1317
++ G
Sbjct: 1079 TVSG 1082
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 641 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 680
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 681 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 740
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 741 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 794
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 795 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 852
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 853 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 905
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 906 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 961
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 962 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1078
Query: 1314 SIKG 1317
++ G
Sbjct: 1079 TVSG 1082
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 791 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 830
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 831 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 890
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 891 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 944
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 945 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 1002
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 1003 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 1055
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 1056 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 1111
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 1112 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1228
Query: 1314 SIKG 1317
++ G
Sbjct: 1229 TVSG 1232
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 389 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 447
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 448 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 502
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 503 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 562
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 563 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 726 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 765
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 766 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 825
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 826 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 879
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 880 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 937
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 938 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 990
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 991 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 1046
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 1047 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1163
Query: 1314 SIKG 1317
++ G
Sbjct: 1164 TVSG 1167
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 324 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 382
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 383 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 437
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 438 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 497
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 498 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 732 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 791
Query: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
+YF YN M + A N Q + Y F Y
Sbjct: 792 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 831
Query: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
+ + + W+ F DWL P++ +L +
Sbjct: 832 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 891
Query: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 892 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 945
Query: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 946 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 1003
Query: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 1004 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 1056
Query: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 1057 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 1112
Query: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 1113 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1171
Query: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1172 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1229
Query: 1314 SIKG 1317
++ G
Sbjct: 1230 TVSG 1233
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 390 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 448
Query: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 449 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 503
Query: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 504 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 563
Query: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 564 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 613
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 110 bits (275), Expect = 9e-24
Identities = 84/275 (30%), Positives = 128/275 (46%), Gaps = 20/275 (7%)
Query: 554 LAIGGYKGKDYSE---AEALIMTF------SLNNYPAGDPRLAQAKLWEEAFLEEMRAFQ 604
L +GG E AEAL TF L + GD + EE ++A+Q
Sbjct: 297 LLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQ 356
Query: 605 RRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVI-------FLYISLALGSYSSW 657
RR + Q S + +T D + A S + L ++ A + W
Sbjct: 357 RRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRW 416
Query: 658 SRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIF 717
S+ ++GL GV +V AV + +G + LGI + QV+PFL L +G D++F+
Sbjct: 417 D--CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFL- 473
Query: 718 VLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSG 777
L + PG P + +G L R S++L S++ F + AL P+PA+R F+L +
Sbjct: 474 -LAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAA 532
Query: 778 LAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
+ V F+ M F A+LSLD +R+ RLDV CC
Sbjct: 533 IVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/215 (35%), Positives = 116/215 (53%), Gaps = 18/215 (8%)
Query: 1056 LKNSQDYTEALRAARELAANI-TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLF 1114
L+ + D+ EA+ AR A A + P P +F+EQYL + F
Sbjct: 917 LQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPF----------LFWEQYLGL--RRCF 964
Query: 1115 MLSLC--LVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLV 1172
+L++C LV TF V LLL +GL+ +L + M+ V+ G M GI +A+ ++ LV
Sbjct: 965 LLAVCILLVCTFLVCALLLLNPWTAGLI-VLVLAMMTVELFGIMGFLGIKLSAIPVVILV 1023
Query: 1173 SAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKA 1232
++VG+ VEF H+ F ++T+ + RA A + V G A++ L G+L+L +
Sbjct: 1024 ASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHF 1081
Query: 1233 QLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1267
I +FF ++TLLGLLHGLV LPV+LS +GP
Sbjct: 1082 DFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
Score = 35.0 bits (79), Expect = 0.48
Identities = 34/128 (26%), Positives = 61/128 (47%), Gaps = 4/128 (3%)
Query: 1138 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINL-VSAVGMSVEFVSHITRSFAISTKPT 1196
GL +L + + + +G AL GI++NA + L A+G+ V+ V + +F + T
Sbjct: 426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGT 485
Query: 1197 WL-ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGL 1255
L ER E G++V ++ N+ L+ L ++ F + +++ + L
Sbjct: 486 PLQERMGECLQRTGTSVVL-TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVML 544
Query: 1256 VFLPVILS 1263
VF P ILS
Sbjct: 545 VF-PAILS 551
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 103 bits (256), Expect = 1e-21
Identities = 169/777 (21%), Positives = 309/777 (39%), Gaps = 130/777 (16%)
Query: 560 KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAER 619
K + A A+ +T+ L Y + L K WE F + +R Q + Q+ +A
Sbjct: 146 KDQRVKSARAIQITYYLQTYGSATQDLIGEK-WENEFCKLIRKLQEEHQEL-QLYSLASF 203
Query: 620 SLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGA 679
SL + ++T+ I A S +++ L + L + SS + + SK LGL GV V +
Sbjct: 204 SLWRDFHKTS-----ILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCIS 258
Query: 680 VMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRA 739
++ A G F + + +L +PF + G +F + ++R + P + I A
Sbjct: 259 IITAAGIFFITDGKYNSTLLG-IPFFAMGHGTKGVFELLSGWRR--TKENLPFKDRIADA 315
Query: 740 LGRVAPSMLLCSLSEAICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 797
V + + S I F +GA T + AV+ F ++++L++ S F + L
Sbjct: 316 YSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVF 375
Query: 798 DSKRQEASRLDVCCCVKP------------QELPPPGQGE-----------GLLLGFFQK 834
+ ++ + CC P Q + G + + F ++
Sbjct: 376 AGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLRE 435
Query: 835 AYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF 894
Y ++ + + V++L+L S IS G + L DS + Y + +YF
Sbjct: 436 HYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYF 495
Query: 895 EVGAPV---YFVTTLGY-NFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPA 950
+PV Y L Y N S + + +CS FT A
Sbjct: 496 SNYSPVIGFYVYEPLEYWNSSVQDDLRRLCS-------GFT------------------A 530
Query: 951 SSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHK 1010
SWV+ + +L S+ +S NK F +V + LK
Sbjct: 531 VSWVEQYYQFLKVSN-----VSANNKSDFI--SVLQSSFLKK------------------ 565
Query: 1011 YLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQ-DYTEALRAA 1069
P F + R +I K G + ++ASR + ++ Q + TE L
Sbjct: 566 --PEFQHFRNDIIFSKAG-----------DESNIIASRLYLVARTSRDKQKEITEVLEKL 612
Query: 1070 RELAANITADLRKVPGTDPAFEVFPYTITNVFYEQY-----LTILPEGLFMLSLCLVPTF 1124
R L +++ +R + +P+F VF + Y + +L G F + L L+ TF
Sbjct: 613 RPL--SLSKSIRFIV-FNPSF---------VFMDHYSLSVTVPVLIAG-FGVLLVLILTF 659
Query: 1125 AVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSH 1184
+ LG +LS+ I + +G M LW + + +S++ L+ + +++ +
Sbjct: 660 FLVIHPLG-----NFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAP 714
Query: 1185 ITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNL 1244
+ +F ++T+ T + K + G+A+ V + L G++ L + L F+ L
Sbjct: 715 LLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL-TFTLFKCLL 772
Query: 1245 LITLLGLLHGLVFLPVILSYVGPDV--NPALALEQKRAEEAVAAVMVASCPNHPSRV 1299
L LLH V LPV L++ P + +++ E + + + P+H + V
Sbjct: 773 LTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV 829
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 99.4 bits (246), Expect = 2e-20
Identities = 130/598 (21%), Positives = 244/598 (40%), Gaps = 85/598 (14%)
Query: 336 LLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFT--ELTTDPVELWSAPNSQARSE 393
LL + FQ G V + P L+ ++ AL G ++ + D E ++ S A++E
Sbjct: 122 LLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAE 181
Query: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFS-GILDLDLLLELLELQERLR 452
+ F HF TN + +R S + + L ++S +LD E+ +L ++
Sbjct: 182 RRFVQGHF----TTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQ 237
Query: 453 HLQVWSPEAQRNISLQDIC--YAPLNPDNTSLYDCCI--NSLLQYFQNNRTLLLLTANQT 508
L+V + E I Q +C Y L C+ N +L +Q N+TL L + +
Sbjct: 238 DLRV-AREKGSQIQYQQVCARYRAL----------CVPPNPILYAWQVNKTLNLSSISFP 286
Query: 509 LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAE 568
H LY + G +L + G+ A+
Sbjct: 287 AYNHGR------HPLYLTGFFGGYILGGSLGM--------------------GQLLLRAK 320
Query: 569 ALIMTFSLNNYPAGDPRL-AQAKLWEEAFLEEMRAFQRRMA-GMFQVTFMAERSLEDEIN 626
A+ + + L DP Q+K W L++ + +A +V S + E
Sbjct: 321 AMRLLYYLKTE---DPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFE 377
Query: 627 RTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGF 686
T+ +P+F +YI+I L+ + + + +K + GV AV++ G
Sbjct: 378 ATSVTVIPVFHLAYILIILFAVTSCFRFDC-----IRNKMCVAAFGVISAFLAVVSGFGL 432
Query: 687 FSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPS 746
++G+ ++I+ PFL+L VG D++FI + + + + RE + + A S
Sbjct: 433 LLHIGV-PFVIIVANSPFLILGVGVDDMFIMISAWHKT-NLADDIRE-RMSNVYSKAAVS 489
Query: 747 MLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASR 806
+ + +++ + + G ++ +V+ F + +G+ ++ + ++ F A ++LD KR+
Sbjct: 490 ITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREV--- 546
Query: 807 LDVCCCVKPQELP----------------PPGQGEGL--LLGFFQKAYAPFLLHWITRGV 848
VC C + P P G + + FF+ + PFL ++
Sbjct: 547 --VCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYF 604
Query: 849 VLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF-EVGAPVYFVTT 905
V+ +++ S+Y H+ GLD DSY+ YF YF + G V + T
Sbjct: 605 VVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVT 662
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 89.7 bits (221), Expect = 2e-17
Identities = 208/976 (21%), Positives = 380/976 (38%), Gaps = 173/976 (17%)
Query: 334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSE 393
H L F G ++AS P+ V+ + L A ++ L + +S A+ E
Sbjct: 7 HRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIE 66
Query: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRH 453
+ + F P R+ L + ++ RY +++ + +LD +L+L +
Sbjct: 67 RNLVNSLF-PVNRSKHR-LYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTK 124
Query: 454 LQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQT 513
+QV P N + IC LN D T + D ++ +L+ +N R N+T T
Sbjct: 125 IQV--PRPGFNYTFAHICI--LNNDKTCIVDDIVH-VLEELKNARA-----TNRTNFAIT 174
Query: 514 SQVDWKDHFLYCANAPLT-FKDGTALALSCMADYGAPVFPFLAIGGYK--GKD-YSEAEA 569
P+T KDG A V+ +GG KD AEA
Sbjct: 175 Y--------------PITHLKDGRA------------VYNGHQLGGVTVHSKDRVKSAEA 208
Query: 570 LIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTT 629
+ +T+ L + + + +A+ WE +F + +R FQ+ + + + + SL ++ +T+
Sbjct: 209 IQLTYYLQSINSLNDMVAER--WESSFCDTVRLFQKSNSKVKMYPYTSS-SLREDFQKTS 265
Query: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSY 689
TS I++ L V SK LGL G+ + A + A G +
Sbjct: 266 RVSERYLVTSLILVVTMAILCCSMQDC-----VRSKPWLGLLGLVTISLATLTAAGIINL 320
Query: 690 LGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLL 749
G + + L V PF++L G F + + R+ E + V R A SML
Sbjct: 321 TGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSW----RKTREDQHVK-ERTAAVYADSMLS 374
Query: 750 CSLSEA---ICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
SL+ A + F +GA T + A R F S +A+ ++L +S + + L +
Sbjct: 375 FSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSSLVFTGYIENN 434
Query: 805 SRLDVCCCVKP-----QELPP-------------PGQGEG-------LLLGFFQKAYAPF 839
+ + C P QE P +GE LL+ F ++ Y +
Sbjct: 435 YQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDW 494
Query: 840 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAP 899
+ + + V+L +L +L +S G D + + ++Y +YF
Sbjct: 495 ITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFS---- 550
Query: 900 VYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFID 959
N+S G S N ++Y F SW + +++
Sbjct: 551 ---------NYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVR--------ISWFESYLN 593
Query: 960 WLTPSSCCRLYIS-GPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLND 1018
+L +L +S G K F NS LK P F +
Sbjct: 594 YLR-----KLNVSTGLPKKNFTDMLRNSF--LK--------------------APQFSHF 626
Query: 1019 RPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLK-NSQDYTEALRAARELAANIT 1077
+ +I K Y+ V+ V+ASR K ++ N ++ + L R L ++T
Sbjct: 627 QEDIIFSK----KYNDEVD------VVASRMFLVAKTMETNREELYDLLETLRRL--SVT 674
Query: 1078 ADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRS 1137
+ ++ + +P+F V+ ++Y + L G + + C+ F + +
Sbjct: 675 SKVKFIV-FNPSF---------VYMDRYASSL--GAPLHNSCISALFLL--FFSAFLVAD 720
Query: 1138 GLLNL---LSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAIS-- 1192
L+N+ L++V + +GFM LW + + +S++ L+ + +++ + + +F +
Sbjct: 721 SLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD 780
Query: 1193 -TKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGL 1251
T+ W++ A E G A+ + + G++ L + L FR LI +
Sbjct: 781 FTRTKWVKNALEV---HGVAILQSY-LCYIVGLIPLAAVPSNL-TCTLFRCLFLIAFVTF 835
Query: 1252 LHGLVFLPVILSYVGP 1267
H LPVIL+++ P
Sbjct: 836 FHCFAILPVILTFLPP 851
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 74.3 bits (181), Expect = 7e-13
Identities = 54/192 (28%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRV-MVDSKATLGLGGVAVVLGAVMAAMGFFS 688
AE +P+ T+YI++F YI Y S ++ MV SK L L V VL +++ ++G +
Sbjct: 283 AELIPL-VTTYIILFAYI------YFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCT 335
Query: 689 YLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSML 748
G+ +L ++ P+LV+ +G +N+ + P ++ I + L + S++
Sbjct: 336 LFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTP--VDLEVKLRIAQGLSSESWSIM 393
Query: 749 LCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLD 808
+E +G T +PA++ F L + + ++ DF LQM F +LS+D +R E + L+
Sbjct: 394 KNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN 453
Query: 809 VCCCVKPQELPP 820
+ LPP
Sbjct: 454 -------KRLPP 458
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 49.3 bits (116), Expect = 2e-05
Identities = 58/256 (22%), Positives = 106/256 (41%), Gaps = 24/256 (9%)
Query: 576 LNNYPAGDPRLAQAKLWEEAFLEEMRAF-QRRMAGMFQVTFMAERSLEDEINRTTAED-- 632
L NY + D R + + ++F+ A ++ QV + + E+ RT D
Sbjct: 405 LPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDML 464
Query: 633 LPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGI 692
L ++S I +YI + + S+ G ++ L ++A + GI
Sbjct: 465 LAFISSSCIAALVYILTSCSVFLSF------------FGIASIGLSCLVALFLYHVVFGI 512
Query: 693 RSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPR-RPGEPREVHIGRALGRVAPSMLLCS 751
+ ++ V F+++ +G D++F+F+ Y++ + R +H + G+ + S
Sbjct: 513 QYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGK---ATFFTS 569
Query: 752 LSEAICFFLGALTPMPAVRTFALTSGLAVI---LDFLLQMSAFVALLSLDSKRQEASRLD 808
L+ A + + +PAV F L L V L L+ M A + L SL E+S
Sbjct: 570 LTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQT 629
Query: 809 VC--CCVKPQELPPPG 822
C C + L PG
Sbjct: 630 SCHQNCSRKTSLHFPG 645
>gi|25121980 dispatched B [Homo sapiens]
Length = 1401
Score = 48.9 bits (115), Expect = 3e-05
Identities = 52/224 (23%), Positives = 90/224 (40%), Gaps = 11/224 (4%)
Query: 1009 HKYLPW----FLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTE 1064
H PW FL+ + +G + + G LA+ + + +NS DY +
Sbjct: 861 HSDFPWAPQFFLHCLKMMALEQGPDGTQDLGLRFDAHGS-LAALVLQFQTNFRNSPDYNQ 919
Query: 1065 ALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTF 1124
E++ + A+L P P +T Y ++ E +L L L F
Sbjct: 920 TQLFYNEVSHWLAAELGMAP---PGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALALAF 976
Query: 1125 AVSCLLLGL-DLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVS 1183
A LLLG ++ L ++ ++ ++ TVG + L N + L ++VG+SV+F
Sbjct: 977 AT--LLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTV 1034
Query: 1184 HITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVL 1227
+ S+ + P L R + A G A G+L+L
Sbjct: 1035 NYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLML 1078
Score = 38.5 bits (88), Expect = 0.043
Identities = 39/149 (26%), Positives = 68/149 (45%), Gaps = 12/149 (8%)
Query: 642 VIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQV 701
++ ++ +AL S + +MV LG VA L V M +F ++ + + L
Sbjct: 496 LVAIFFGMALYLRSLFLTLMV-LLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALL----- 549
Query: 702 VPFLVLSVGADNIFIFVLEYQRLPRR--PGEPREVHIGRALGRVAPSMLLCSLSEAICFF 759
L+ SV A++ IF + RL + P +GR + +L+ L+ + F+
Sbjct: 550 ---LLSSVCANHTLIF-FDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFY 605
Query: 760 LGALTPMPAVRTFALTSGLAVILDFLLQM 788
L+ +PAVR AL G AV++ L +
Sbjct: 606 ASYLSRLPAVRCLALFMGTAVLVHLALTL 634
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 41.2 bits (95), Expect = 0.007
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 3/167 (1%)
Query: 1101 FYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 1160
FY+ ++ L + L + F+V LL ++ L ++SI + TVG + L G
Sbjct: 973 FYDLQDSLSDGTLIAMGLSVAVAFSVM-LLTTWNIIISLYAIISIAGTIFVTVGSLVLLG 1031
Query: 1161 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTN 1220
N + + + AVG+SV+F H ++ ++ P + + +GSA+ T
Sbjct: 1032 WELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTF 1091
Query: 1221 LPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1267
+ G +++ Q+ F +LI + F + +GP
Sbjct: 1092 VAGAMMMPSTVLAYTQLGTFM--MLIMCISWAFATFFFQCMCRCLGP 1136
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/64 (35%), Positives = 38/64 (59%), Gaps = 7/64 (10%)
Query: 1095 YTITNVFYEQYLTILPEGLFMLSLCLV--PTFAVSCLLLGLDLRSGLLNLL---SIVMIL 1149
+ + F+++ ++LPEGL++L+ P+F S LL LDL LL LL ++V ++
Sbjct: 343 FILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTS--LLSLDLIEPLLQLLPVSNVVSVM 400
Query: 1150 VDTV 1153
V TV
Sbjct: 401 VLTV 404
>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 2 [Homo sapiens]
Length = 2277
Score = 32.3 bits (72), Expect = 3.1
Identities = 12/52 (23%), Positives = 28/52 (53%)
Query: 442 LELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQY 493
+ +LE +++ ++ S E + ++ + +C + NPD++ LY C N +
Sbjct: 609 ITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF 660
>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 1 [Homo sapiens]
Length = 2796
Score = 32.3 bits (72), Expect = 3.1
Identities = 12/52 (23%), Positives = 28/52 (53%)
Query: 442 LELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQY 493
+ +LE +++ ++ S E + ++ + +C + NPD++ LY C N +
Sbjct: 1128 ITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF 1179
>gi|14550407 complement component 2 isoform 1 preproprotein [Homo
sapiens]
Length = 752
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 15/89 (16%)
Query: 30 PGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPR-LYTGPNTQ 88
PG C +N +SG TLS+ + LL CP+ LY P ++
Sbjct: 15 PGLADSAPSCPQNVNISGGTFTLSHGWAPGS------------LLTYSCPQGLYPSPASR 62
Query: 89 ACCSAKQLVSLEASLSITKALL--TRCPA 115
C S+ Q + A+ S++KA+ RCPA
Sbjct: 63 LCKSSGQWQTPGATRSLSKAVCKPVRCPA 91
>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
sapiens]
Length = 2799
Score = 32.3 bits (72), Expect = 3.1
Identities = 12/52 (23%), Positives = 28/52 (53%)
Query: 442 LELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQY 493
+ +LE +++ ++ S E + ++ + +C + NPD++ LY C N +
Sbjct: 1130 ITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF 1181
>gi|27437051 colony stimulating factor 3 isoform c [Homo sapiens]
Length = 200
Score = 32.0 bits (71), Expect = 4.1
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 9/61 (14%)
Query: 55 VSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCP 114
+ CL RKI GD L +K+C T C ++LV L SL I A L+ CP
Sbjct: 41 LKCLEQV--RKIQGDGAALQEKLCA-------TYKLCHPEELVLLGHSLGIPWAPLSSCP 91
Query: 115 A 115
+
Sbjct: 92 S 92
>gi|27437049 colony stimulating factor 3 isoform b precursor [Homo
sapiens]
Length = 204
Score = 32.0 bits (71), Expect = 4.1
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 9/61 (14%)
Query: 55 VSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCP 114
+ CL RKI GD L +K+C T C ++LV L SL I A L+ CP
Sbjct: 45 LKCLEQV--RKIQGDGAALQEKLCA-------TYKLCHPEELVLLGHSLGIPWAPLSSCP 95
Query: 115 A 115
+
Sbjct: 96 S 96
>gi|105990532 apolipoprotein B precursor [Homo sapiens]
Length = 4563
Score = 30.8 bits (68), Expect = 9.1
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 1032 YSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFE 1091
YST V SD LA++ + + QD+ + ++A E + +++ + GT PAFE
Sbjct: 2543 YSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTV-PEIKTILGTMPAFE 2601
Query: 1092 V 1092
V
Sbjct: 2602 V 2602
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 30.8 bits (68), Expect = 9.1
Identities = 51/160 (31%), Positives = 69/160 (43%), Gaps = 29/160 (18%)
Query: 963 PSSC--CRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
P SC C YI +K C +V + C K C+ Q H + P
Sbjct: 1643 PQSCEQCLSYIWLMDKALLC--SVCKMTCHKKCVHKI---------QSHCSYTYGRKGEP 1691
Query: 1021 NIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQD---YTEALRAARELAANIT 1077
++ G+ S LTSD AS + K L++ + YTE L + AAN T
Sbjct: 1692 GVEPGHFGVCVDS----LTSDK---ASVPIVLEKLLEHVEMHGLYTEGLYR-KSGAANRT 1743
Query: 1078 ADLRKVPGTDPA---FEVFP-YTITNVFYEQYLTILPEGL 1113
+LR+ TDPA E FP + IT V +Q+L LPE L
Sbjct: 1744 RELRQALQTDPAAVKLENFPIHAITGVL-KQWLRELPEPL 1782
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 30.8 bits (68), Expect = 9.1
Identities = 51/160 (31%), Positives = 69/160 (43%), Gaps = 29/160 (18%)
Query: 963 PSSC--CRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP 1020
P SC C YI +K C +V + C K C+ Q H + P
Sbjct: 1643 PQSCEQCLSYIWLMDKALLC--SVCKMTCHKKCVHKI---------QSHCSYTYGRKGEP 1691
Query: 1021 NIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQD---YTEALRAARELAANIT 1077
++ G+ S LTSD AS + K L++ + YTE L + AAN T
Sbjct: 1692 GVEPGHFGVCVDS----LTSDK---ASVPIVLEKLLEHVEMHGLYTEGLYR-KSGAANRT 1743
Query: 1078 ADLRKVPGTDPA---FEVFP-YTITNVFYEQYLTILPEGL 1113
+LR+ TDPA E FP + IT V +Q+L LPE L
Sbjct: 1744 RELRQALQTDPAAVKLENFPIHAITGVL-KQWLRELPEPL 1782
>gi|194473684 chondroitin sulfate N-acetylgalactosaminyltransferase
1 [Homo sapiens]
Length = 532
Score = 30.8 bits (68), Expect = 9.1
Identities = 17/40 (42%), Positives = 24/40 (60%)
Query: 840 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPK 879
LL WI+R VVLL+ L LY + G +++LALP+
Sbjct: 8 LLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPR 47
>gi|194473683 chondroitin sulfate N-acetylgalactosaminyltransferase
1 [Homo sapiens]
Length = 532
Score = 30.8 bits (68), Expect = 9.1
Identities = 17/40 (42%), Positives = 24/40 (60%)
Query: 840 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPK 879
LL WI+R VVLL+ L LY + G +++LALP+
Sbjct: 8 LLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPR 47
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,166,556
Number of Sequences: 37866
Number of extensions: 2165790
Number of successful extensions: 6315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 6204
Number of HSP's gapped (non-prelim): 70
length of query: 1332
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1218
effective length of database: 13,930,794
effective search space: 16967707092
effective search space used: 16967707092
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.