Guide to the Human Genome
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Search of human proteins with 156104893

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
         (663 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1343   0.0  
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1333   0.0  
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1317   0.0  
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]   1305   0.0  
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1294   0.0  
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1276   0.0  
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1274   0.0  
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat...   978   0.0  
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]               810   0.0  
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]              573   e-163
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]               568   e-162
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]           468   e-131
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]         459   e-129
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,...   350   2e-96
gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]                176   6e-44
gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]                176   6e-44
gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]                176   6e-44
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...   144   3e-34
gi|7661880 centaurin beta1 [Homo sapiens]                             131   2e-30
gi|187608516 centaurin, beta 2 [Homo sapiens]                         131   2e-30
gi|46094081 development and differentiation enhancing factor 1 [...   130   3e-30
gi|206725422 G protein-coupled receptor kinase interacting ArfGA...   125   2e-28
gi|206725420 G protein-coupled receptor kinase interacting ArfGA...   125   2e-28
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP...   125   2e-28
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP...   125   2e-28
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP...   125   2e-28
gi|206725415 G protein-coupled receptor kinase interacting ArfGA...   125   2e-28
gi|146231998 G protein-coupled receptor kinase interactor 1 isof...   122   1e-27
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo...   122   1e-27
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai...   118   2e-26

>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 4 [Homo sapiens]
          Length = 663

 Score = 1343 bits (3476), Expect = 0.0
 Identities = 663/663 (100%), Positives = 663/663 (100%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
           DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
Sbjct: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120

Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
           LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180

Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
           KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240

Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
           KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300

Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS 360
           KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS 360

Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
           TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420

Query: 421 ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
           ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480

Query: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
           GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
Sbjct: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540

Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600
           ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600

Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
           GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660

Query: 661 KCV 663
           KCV
Sbjct: 661 KCV 663


>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 8 [Homo sapiens]
          Length = 663

 Score = 1333 bits (3451), Expect = 0.0
 Identities = 658/663 (99%), Positives = 661/663 (99%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
           DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
Sbjct: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120

Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
           LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180

Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
           KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240

Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
           KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300

Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS 360
           KNIHKKEIDLQTSTIKVPGKWPSLATSACTPIS+SKSNGLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS 360

Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
           TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420

Query: 421 ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
           ASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480

Query: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
           GIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
Sbjct: 481 GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540

Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600
           ERWIRSKYEEKLFLAPLPCTELSLGQQLL ATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD 600

Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
           GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660

Query: 661 KCV 663
           +CV
Sbjct: 661 ECV 663


>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 7 [Homo sapiens]
          Length = 663

 Score = 1317 bits (3408), Expect = 0.0
 Identities = 650/663 (98%), Positives = 656/663 (98%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
           DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTV FSQQYS
Sbjct: 61  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVHFSQQYS 120

Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
           LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHI K
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITK 180

Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
            RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 NRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240

Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
           KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300

Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS 360
           K IHKKEIDLQTSTIKVPGKWPSLAT ACTPIS+SKS+GLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKSDGLSKDMDTGLGDSICFSPSISS 360

Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
           TT PKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTIPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420

Query: 421 ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
           ASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480

Query: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
           GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQG+TKP+EKSTREEK
Sbjct: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEK 540

Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600
           ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600

Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
           GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660

Query: 661 KCV 663
           +CV
Sbjct: 661 ECV 663


>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
          Length = 686

 Score = 1305 bits (3378), Expect = 0.0
 Identities = 651/686 (94%), Positives = 656/686 (95%), Gaps = 23/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
           DLHMHHVRDREMPEALEFN                       PSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120

Query: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
           VVEIRRSNCTNHVS VRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPIS+SKS
Sbjct: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360

Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
           DCETQNPKWASLNLGVLMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540

Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577
           NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600

Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 638 LTYARQASSQECINVLLQYGCPDKCV 663
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 5 [Homo sapiens]
          Length = 686

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 646/686 (94%), Positives = 652/686 (95%), Gaps = 23/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEF-----------------------NPSANPEASTIFQRNSQTD 97
           DLHMHH+RD+EMPEALEF                       NPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120

Query: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
           VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180

Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PIS+SKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
           D ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540

Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577
           NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600

Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 638 LTYARQASSQECINVLLQYGCPDKCV 663
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 9 [Homo sapiens]
          Length = 684

 Score = 1276 bits (3303), Expect = 0.0
 Identities = 641/686 (93%), Positives = 647/686 (94%), Gaps = 25/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
           DLHMH VRDREMPEALEFN                        SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
           VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
           TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PIS+SKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
           DCETQNPKWASLNLGVLMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577
           NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 638 LTYARQASSQECINVLLQYGCPDKCV 663
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 10 [Homo sapiens]
          Length = 684

 Score = 1274 bits (3296), Expect = 0.0
 Identities = 640/686 (93%), Positives = 646/686 (94%), Gaps = 25/686 (3%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
           DLHMH VRDREMPEALEFN                        SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
           VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
           TPVCK SMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PIS+SKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
           DCETQNPKWASLNLGVLMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577
           NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 638 LTYARQASSQECINVLLQYGCPDKCV 663
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
           protein 11 [Homo sapiens]
          Length = 550

 Score =  978 bits (2527), Expect = 0.0
 Identities = 493/550 (89%), Positives = 507/550 (92%), Gaps = 25/550 (4%)

Query: 139 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 198
           MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 1   MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60

Query: 199 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 258
           PSTSQED  FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 61  PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120

Query: 259 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 318
           IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180

Query: 319 GKWPSLATSACTPISTSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 369
           GKWPSLATSAC PIS+SKSNGLSKDM         D GLGDSICFSPSISSTTSPKLN P
Sbjct: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240

Query: 370 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 413
           PSPHANKKKHLKKKSTNN                FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300

Query: 414 AIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 473
           AIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360

Query: 474 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSE 533
           LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS 
Sbjct: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420

Query: 534 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVN 593
           +STREEKERWIRSKYE KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGSREEVN
Sbjct: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480

Query: 594 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 653
           ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540

Query: 654 LQYGCPDKCV 663
           LQYGCPD+CV
Sbjct: 541 LQYGCPDECV 550


>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
          Length = 804

 Score =  810 bits (2092), Expect = 0.0
 Identities = 411/532 (77%), Positives = 454/532 (85%), Gaps = 32/532 (6%)

Query: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           S+P+   HS      VS VHI +  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
           TPV K+S R SNLFTS KGSDPDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSK 336
           WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSAC PIS+ K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 337 SNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNN 387
           +NGLSKDM         DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+N
Sbjct: 425 TNGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSN 484

Query: 388 F------------------MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESS 429
           F                  +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESS
Sbjct: 485 FKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESS 544

Query: 430 KSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTR 489
           K+KS+LTSQS+AMALQSI+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LGT 
Sbjct: 545 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTH 604

Query: 490 LSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYE 549
           LSRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPS  STREEKERWIR+KYE
Sbjct: 605 LSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYE 664

Query: 550 EKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLAC 609
           +KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLAC
Sbjct: 665 QKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLAC 724

Query: 610 RKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDK 661
           RKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPD+
Sbjct: 725 RKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 776


>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
          Length = 911

 Score =  573 bits (1476), Expect = e-163
 Identities = 305/580 (52%), Positives = 388/580 (66%), Gaps = 82/580 (14%)

Query: 162 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 216
           S+P+   HS     ++  VHI +  NGGGS  ++YSSS+PSTPS SQ + +      ++T
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360

Query: 217 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 275
           PTP+ K+S R SN+FTS KG+D D+E+KA E   D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420

Query: 276 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 331
            WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL  +T+KVPGK    AT A  P    
Sbjct: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480

Query: 332 ----ISTSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 360
               +S  +SN                S   +  L  S    P          S+SS   
Sbjct: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540

Query: 361 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 387
                                  ++SPKL+PPPSPH+N+KKH +KKST            
Sbjct: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600

Query: 388 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 439
                   F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660

Query: 440 KAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 499
            A+A+Q+++ +RGN+ C+DC+  NP WASLNLG LMCIECSGIHR LG  LSRVRSL+LD
Sbjct: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720

Query: 500 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 559
           DWP EL  VM+++GN LANS+WEG+  G +KP   + REEKERWIR+KYE+KLFLAPLP 
Sbjct: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780

Query: 560 TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 619
           +++ LGQQLLRA  ++DL+  ++LLAHGS+EEVNET G+GDG TALHL+    NVV  QL
Sbjct: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840

Query: 620 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCP 659
           LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP
Sbjct: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCP 880


>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
          Length = 857

 Score =  568 bits (1463), Expect = e-162
 Identities = 280/335 (83%), Positives = 303/335 (90%), Gaps = 18/335 (5%)

Query: 345 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 388
           DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF                
Sbjct: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554

Query: 389 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQS 446
             +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQS+AMALQS
Sbjct: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614

Query: 447 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELR 506
           I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL 
Sbjct: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674

Query: 507 KVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 566
           KVMSSIGN+LANS+WE SSQG+TKPS  STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734

Query: 567 QLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 626
            LLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794

Query: 627 VMARDAHGNTALTYARQASSQECINVLLQYGCPDK 661
           V ARDAHGNTAL YARQASSQECI+VLLQYGCPD+
Sbjct: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829



 Score =  257 bits (656), Expect = 3e-68
 Identities = 136/207 (65%), Positives = 159/207 (76%), Gaps = 10/207 (4%)

Query: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
           S+P+   HS      VS VHI +  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
           TPV K+S R SNLFTS KGSDPDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSK 336
           WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSAC PIS+ K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 337 SNGLSKDMDTGLGDSICFSPSISSTTS 363
           +NGLSKDM      S+  SP+  + TS
Sbjct: 425 TNGLSKDM-----SSLHISPNSGNVTS 446


>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
          Length = 836

 Score =  468 bits (1203), Expect = e-131
 Identities = 263/555 (47%), Positives = 346/555 (62%), Gaps = 63/555 (11%)

Query: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
           S+P    HS A + V    + + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302

Query: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
           + + + R ++LF + +GSD   E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360

Query: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSN 338
           KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  ++  N
Sbjct: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418

Query: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
           GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478

Query: 365 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 404
                    PPPSP   K++  K              ++    F+IVS+TGQTWHFEA +
Sbjct: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538

Query: 405 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNP 464
           +EERDAWVQAI+SQILASLQ CESSK K +  SQS+A+A+Q+I+N +GN+ CVDC   NP
Sbjct: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598

Query: 465 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 524
            WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL  V+++IGND AN +WE  
Sbjct: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658

Query: 525 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLL 584
           ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  LG+QL  A   +D+ T +LLL
Sbjct: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718

Query: 585 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 644
           AH     ++ +  +    + LHLA    +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778

Query: 645 SSQECINVLLQYGCP 659
            SQ C ++LLQ+GCP
Sbjct: 779 GSQLCADILLQHGCP 793


>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
          Length = 1192

 Score =  459 bits (1182), Expect = e-129
 Identities = 263/575 (45%), Positives = 346/575 (60%), Gaps = 83/575 (14%)

Query: 162  SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
            S+P    HS A + V    + + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 581  SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638

Query: 220  VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
            + + + R ++LF + +GSD   E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 639  LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696

Query: 279  KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSN 338
            KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  ++  N
Sbjct: 697  KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754

Query: 339  GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
            GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 755  GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814

Query: 365  ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 387
                     PPPSP   K++  K  + +                                
Sbjct: 815  GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874

Query: 388  ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMAL 444
               F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K +  SQS+A+A+
Sbjct: 875  NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934

Query: 445  QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVE 504
            Q+I+N +GN+ CVDC   NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP E
Sbjct: 935  QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994

Query: 505  LRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 564
            L  V+++IGND AN +WE  ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  L
Sbjct: 995  LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054

Query: 565  GQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 624
            G+QL  A   +D+ T +LLLAH     ++ +  +    + LHLA    +VV+ QLL+WYG
Sbjct: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114

Query: 625  VDVMARDAHGNTALTYARQASSQECINVLLQYGCP 659
             DV ARDA G TAL YARQA SQ C ++LLQ+GCP
Sbjct: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCP 1149


>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
           member 1 [Homo sapiens]
          Length = 284

 Score =  350 bits (898), Expect = 2e-96
 Identities = 171/173 (98%), Positives = 173/173 (100%)

Query: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 550
           SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 171

Query: 551 KLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 610
           KLFLAPLPCT+LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR
Sbjct: 172 KLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 231

Query: 611 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDKCV 663
           KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD+CV
Sbjct: 232 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 284



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 18/18 (100%), Positives = 18/18 (100%)

Query: 155 RDADRSLSIPDEQLHSFA 172
           RDADRSLSIPDEQLHSFA
Sbjct: 94  RDADRSLSIPDEQLHSFA 111


>gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  176 bits (446), Expect = 6e-44
 Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
            LHMHH+ +REMPE   LE NPS +P+ASTIF R SQTDV E ++      VST  F+QQ
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119

Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
           YS CSTIFLDDS A Q +LTMT+ S      I  +  +RDA RSL I DEQLH   V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176


>gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  176 bits (446), Expect = 6e-44
 Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
            LHMHH+ +REMPE   LE NPS +P+ASTIF R SQTDV E ++      VST  F+QQ
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119

Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
           YS CSTIFLDDS A Q +LTMT+ S      I  +  +RDA RSL I DEQLH   V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176


>gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  176 bits (446), Expect = 6e-44
 Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)

Query: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC V P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
            LHMHH+ +REMPE   LE NPS +P+ASTIF R SQTDV E ++      VST  F+QQ
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119

Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
           YS CSTIFLDDS A Q +LTMT+ S      I  +  +RDA RSL I DEQLH   V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score =  144 bits (362), Expect = 3e-34
 Identities = 81/192 (42%), Positives = 113/192 (58%), Gaps = 22/192 (11%)

Query: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 436
           F ++S T ++   +A + + R AWVQA+Q+ I ++ +    SC S       S S S + 
Sbjct: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390

Query: 437 SQSKAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
           S +            LQ +Q++ GN+ C DC   +P+WAS+NLGVL+CIECSGIHRSLG 
Sbjct: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450

Query: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 546
             S+VRSL LD W  EL K+M  +GN   N I+E   +  G  KP+  S+R++KE WI+ 
Sbjct: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510

Query: 547 KYEEKLFLAPLP 558
           KY EK FL   P
Sbjct: 511 KYVEKKFLRKAP 522



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)

Query: 561 ELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 620
           EL  G    RA    DL      LAHG+  EVN    E +G T L  A   G++++ + L
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722

Query: 621 IWYGVDVMARDAHGNTALTYA 641
           +  G DV  RD+ G   L +A
Sbjct: 723 LQNGADVNQRDSRGRAPLHHA 743


>gi|7661880 centaurin beta1 [Homo sapiens]
          Length = 740

 Score =  131 bits (329), Expect = 2e-30
 Identities = 124/428 (28%), Positives = 174/428 (40%), Gaps = 94/428 (21%)

Query: 261 IKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGK 320
           + +G L KR+    KTW +++ T+ SN  L Y     D +  +     DL+  T+K+   
Sbjct: 267 VMEGHLFKRASNAFKTWSRRWFTIQSN-QLVYQKKYKDPVTVVVD---DLRLCTVKL--- 319

Query: 321 WPSLATSAC-TPISTSKSNGLSKDMD--TGLGDSICFSPSISSTTSPKLNPPPSPHANKK 377
            P      C   +STSKS  L  D +    L  S   S   S+ +  +L+  P       
Sbjct: 320 CPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGS 379

Query: 378 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 437
            HL                                 AI S   A+L S   ++ +     
Sbjct: 380 GHL---------------------------------AIGS--AATLGSGGMARGRE---P 401

Query: 438 QSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLE 497
                 +  +Q++ GNA C DC    P+WAS+NLGV +CI+CSGIHRSLG   S+VRSL 
Sbjct: 402 GGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLT 461

Query: 498 LDDWPVELRKVMSSIGNDLANSIWEGSSQGQT--KPSEKSTREEKERWIRSKYEEKLFLA 555
           LD W  EL K+M  +GN + N I+E   +     KP    +R+EKE WI +KY EK FL 
Sbjct: 462 LDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLT 521

Query: 556 PLP-----------------------------------------CTELSLGQQLLRATA- 573
            LP                                            L  G  L RA+  
Sbjct: 522 KLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGH 581

Query: 574 DEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAH 633
              L T    LAHG+  +VN   G  D  T L  A    +++  + L+  G +V   D+ 
Sbjct: 582 PPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSA 639

Query: 634 GNTALTYA 641
           G   L +A
Sbjct: 640 GRGPLHHA 647



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 4/86 (4%)

Query: 568 LLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDV 627
           L++ATA   L     LL +G+     ++ G G     LH A   G+  LA L +  G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGANVNQADSAGRGP----LHHATILGHTGLACLFLKRGADL 666

Query: 628 MARDAHGNTALTYARQASSQECINVL 653
            ARD+ G   LT A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score =  131 bits (329), Expect = 2e-30
 Identities = 75/186 (40%), Positives = 111/186 (59%), Gaps = 21/186 (11%)

Query: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 438
           F +VS T ++   +A + + R AW++A+Q+ I  + +           +SS S   L S 
Sbjct: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388

Query: 439 SKAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRL 490
           +++         ALQ +Q + GNA C DC   +P+WAS+NLG+ +CIECSGIHRSLG   
Sbjct: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448

Query: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 548
           S+VRSL LD W  EL K+M  +GND+ N ++E +    G  KP +   R+EKE +IR+KY
Sbjct: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507

Query: 549 EEKLFL 554
            E+ F+
Sbjct: 508 VERKFV 513



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 557 LPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
           L    L+ G QL RA+ +++L      LAHG+  +VN    E +  T L  A   G++V 
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656

Query: 617 AQLLIWYGVDVMARDAHGNTALTYA 641
            + L+  G +V  RD  G   L +A
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681


>gi|46094081 development and differentiation enhancing factor 1
           [Homo sapiens]
          Length = 1129

 Score =  130 bits (328), Expect = 3e-30
 Identities = 93/293 (31%), Positives = 144/293 (49%), Gaps = 20/293 (6%)

Query: 372 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 428
           P+A  KK     S N         +T+HF+A   ++  AW+  +   + + L      E 
Sbjct: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427

Query: 429 SKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
           S  ++ L   +KA+ ++ +Q + GN  C DC +  P W S NLG+L CIECSGIHR +G 
Sbjct: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486

Query: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 547
            +SR++SLELD        +  ++GN+  N I E +    + KP+  S    ++ +I +K
Sbjct: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546

Query: 548 YEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 605
           Y +  F      T  +   +LL A    DL   I + A G    E + E  G+  G TAL
Sbjct: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605

Query: 606 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
           HLA R   + ++ L   L+    ++  + A GNT L Y    S  EC+ +LL+
Sbjct: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658


>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 5 [Homo sapiens]
          Length = 729

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 6 [Homo sapiens]
          Length = 681

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 3 [Homo sapiens]
          Length = 679

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 1 [Homo sapiens]
          Length = 759

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 2 [Homo sapiens]
          Length = 631

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 4 [Homo sapiens]
          Length = 471

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121

Query: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178

Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229


>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
           1 [Homo sapiens]
          Length = 770

 Score =  122 bits (306), Expect = 1e-27
 Identities = 76/222 (34%), Positives = 115/222 (51%), Gaps = 19/222 (8%)

Query: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
           C DC   +P WAS++ GVL+C EC  +HRSLG  +S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
             L +QL  +    +L+T + LL+ G++           G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187

Query: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLL--QYGCPDK 661
            YG D  + D +G T + YARQA   E    L+  QY   D+
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDR 229


>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
           2 [Homo sapiens]
          Length = 761

 Score =  122 bits (306), Expect = 1e-27
 Identities = 76/222 (34%), Positives = 115/222 (51%), Gaps = 19/222 (8%)

Query: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
           C DC   +P WAS++ GVL+C EC  +HRSLG  +S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
             L +QL  +    +L+T + LL+ G++           G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187

Query: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLL--QYGCPDK 661
            YG D  + D +G T + YARQA   E    L+  QY   D+
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDR 229


>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
           isoform b [Homo sapiens]
          Length = 894

 Score =  118 bits (295), Expect = 2e-26
 Identities = 89/279 (31%), Positives = 135/279 (48%), Gaps = 24/279 (8%)

Query: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKA-----------MAL 444
           +T+HF+A    E +AWV  +Q+    +L S    +  +   S   A           + +
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420

Query: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD-DWPV 503
             +++  GN+ C DC   +P W S NLGVL CI+CSG+HR LG R SR++SL LD   P 
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480

Query: 504 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTE 561
           EL   + ++GN   N + E    S G  KPS +S    +  +I +KY E  F     CT 
Sbjct: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537

Query: 562 LSLGQQLLRATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 616
               Q+L  A  + DL + +   A+G    + +     +      LHLA +  N   + L
Sbjct: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595

Query: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
              +I  G  + A+ A GNTAL YA   +  +C+ +LL+
Sbjct: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.127    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,283,483
Number of Sequences: 37866
Number of extensions: 1213530
Number of successful extensions: 5625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 4096
Number of HSP's gapped (non-prelim): 1427
length of query: 663
length of database: 18,247,518
effective HSP length: 109
effective length of query: 554
effective length of database: 14,120,124
effective search space: 7822548696
effective search space used: 7822548696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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