Search of human proteins with 156104874

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156104874 envoplakin [Homo sapiens]
         (2033 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156104874 envoplakin [Homo sapiens]                               3927   0.0  
gi|45439327 periplakin [Homo sapiens]                                 832   0.0  
gi|223468634 envoplakin-like [Homo sapiens]                           377   e-104
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       356   1e-97
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       356   1e-97
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        356   1e-97
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        356   1e-97
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        356   1e-97
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        356   1e-97
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        356   1e-97
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        356   1e-97
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               307   8e-83
gi|58530842 desmoplakin isoform II [Homo sapiens]                     243   1e-63
gi|58530840 desmoplakin isoform I [Homo sapiens]                      243   1e-63
gi|221316624 dystonin isoform 4 [Homo sapiens]                        211   6e-54
gi|221316622 dystonin isoform 3 [Homo sapiens]                        211   6e-54
gi|221316618 dystonin isoform 2 [Homo sapiens]                        211   6e-54
gi|34577047 dystonin isoform 1 [Homo sapiens]                         211   6e-54
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             211   6e-54
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   175   5e-43
gi|148746195 trichohyalin [Homo sapiens]                              159   2e-38
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        157   1e-37
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    156   2e-37
gi|33188445 microfilament and actin filament cross-linker protei...   153   2e-36
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   146   2e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   146   2e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   146   2e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   146   2e-34
gi|21735548 centrosomal protein 2 [Homo sapiens]                      144   1e-33
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   141   6e-33

>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score = 3927 bits (10184), Expect = 0.0
 Identities = 2033/2033 (100%), Positives = 2033/2033 (100%)

Query: 1    MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILET 60
            MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILET
Sbjct: 1    MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILET 60

Query: 61   QKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIK 120
            QKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIK
Sbjct: 61   QKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIK 120

Query: 121  QLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIA 180
            QLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIA
Sbjct: 121  QLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIA 180

Query: 181  EHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLS 240
            EHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLS
Sbjct: 181  EHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLS 240

Query: 241  ALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPA 300
            ALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPA
Sbjct: 241  ALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPA 300

Query: 301  VGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKY 360
            VGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKY
Sbjct: 301  VGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKY 360

Query: 361  SPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDS 420
            SPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDS
Sbjct: 361  SPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDS 420

Query: 421  ICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASR 480
            ICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASR
Sbjct: 421  ICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASR 480

Query: 481  LASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ 540
            LASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ
Sbjct: 481  LASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ 540

Query: 541  IERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVG 600
            IERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVG
Sbjct: 541  IERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVG 600

Query: 601  PAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAP 660
            PAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAP
Sbjct: 601  PAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAP 660

Query: 661  IPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQ 720
            IPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQ
Sbjct: 661  IPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQ 720

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP
Sbjct: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
            SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA
Sbjct: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDA 900
            PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDA
Sbjct: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDA 900

Query: 901  KQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVV 960
            KQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVV
Sbjct: 901  KQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVV 960

Query: 961  EFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVT 1020
            EFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVT
Sbjct: 961  EFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVT 1020

Query: 1021 QVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVV 1080
            QVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVV
Sbjct: 1021 QVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVV 1080

Query: 1081 KVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVK 1140
            KVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVK
Sbjct: 1081 KVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVK 1140

Query: 1141 KVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIF 1200
            KVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIF
Sbjct: 1141 KVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIF 1200

Query: 1201 QVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRH 1260
            QVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRH
Sbjct: 1201 QVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRH 1260

Query: 1261 ERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH 1320
            ERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH
Sbjct: 1261 ERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH 1320

Query: 1321 EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQK 1380
            EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQK
Sbjct: 1321 EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQK 1380

Query: 1381 DPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELR 1440
            DPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELR
Sbjct: 1381 DPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELR 1440

Query: 1441 QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECK 1500
            QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECK
Sbjct: 1441 QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECK 1500

Query: 1501 NLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRL 1560
            NLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRL
Sbjct: 1501 NLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRL 1560

Query: 1561 RERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLL 1620
            RERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLL
Sbjct: 1561 RERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLL 1620

Query: 1621 SQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRET 1680
            SQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRET
Sbjct: 1621 SQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRET 1680

Query: 1681 NLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLD 1740
            NLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLD
Sbjct: 1681 NLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLD 1740

Query: 1741 RKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSP 1800
            RKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSP
Sbjct: 1741 RKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSP 1800

Query: 1801 LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLE 1860
            LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLE
Sbjct: 1801 LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLE 1860

Query: 1861 AQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEA 1920
            AQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEA
Sbjct: 1861 AQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEA 1920

Query: 1921 VQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEK 1980
            VQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEK
Sbjct: 1921 VQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEK 1980

Query: 1981 DLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYRSASPTVPRSLR 2033
            DLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYRSASPTVPRSLR
Sbjct: 1981 DLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYRSASPTVPRSLR 2033


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  832 bits (2148), Expect = 0.0
 Identities = 538/1778 (30%), Positives = 948/1778 (53%), Gaps = 53/1778 (2%)

Query: 25   KGSPSRHSRA-ATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQET 83
            K SP+  +R+ + +EL+ LI ++Q NADQVE++I++T+ ++Q D    ++ +  +H+  T
Sbjct: 12   KYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVT 71

Query: 84   GRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLP 143
             + + ++E LL  L  D   A+ +KHPQ + I +DI+QL ERVT    +++ +Y   V  
Sbjct: 72   LQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAV-- 129

Query: 144  PDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPD 203
             +V P+V+WA ++E+K  ++    +G  +  ++ Q+ EHNI   E+ A G  L      +
Sbjct: 130  KEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKE 189

Query: 204  A-ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPA 262
              + +R++Y+ LL A+  R Q L SL  ++Q CT +L  L +Q +  +Q DWSD   D  
Sbjct: 190  QNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYP 249

Query: 263  GVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLC 322
              RR+YE+F    L ++E+ +N+L  +G++++   HP    I+AH EA+  +W+ +LNL 
Sbjct: 250  SRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLL 309

Query: 323  ICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEE 382
            IC+E+ L+++EDY +F E+     + L K++S+L+ KY P           LL++L+ +E
Sbjct: 310  ICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIEL-LLRELDDQE 368

Query: 383  KRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDN 442
            K L   E     LQ+R + V PL  RR  P +P+ V+++CD++  +  + +G  Y L  N
Sbjct: 369  KVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428

Query: 443  TDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLA----TVQSR 498
                +W +    G    APA CF IP  DP+A+A A  L S+ ++++QK A    T+Q R
Sbjct: 429  NG-ESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQR 487

Query: 499  LKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTP 558
             +    E+           D ++ Q ++LL  + ++  DL + E+ +    R PL +   
Sbjct: 488  YEVLKTEN---------PGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRA 538

Query: 559  LEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFS 618
            ++D   R    +     L  +  EK  +  E EAF+   P       L   +     K+ 
Sbjct: 539  VQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYE 598

Query: 619  DVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQ 678
             +  L  L  EK   A  LE+ +Q +  ++   E  L Q+  +P     L  +  EL   
Sbjct: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658

Query: 679  RRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQL 738
              EL  Q++ +  + + L+A++   + L + FQE C DL RQ+ +V  L  R++ +  Q+
Sbjct: 659  ACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQV 718

Query: 739  DLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQ 798
            + R + +Q A   Y+ F    D++  +L  +P  + + +D  SQ+  KL+ QK L  EI 
Sbjct: 719  ERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIA 778

Query: 799  SRERDRATASHLSQALQAALQDYELQADTYRC--SLEPTLAVSAPKRPRVAPLQESIQAQ 856
            SRE++       SQ  Q A++DYEL+A+  R    LE   +    KR R+      ++ +
Sbjct: 779  SREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEE 838

Query: 857  EKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEA 916
            E  LA  +TEV A  +Q LQ LEFA  +L ++    ++  TH+  Q +  P     E+  
Sbjct: 839  EAALAAKFTEVYAINRQRLQNLEFALNLLRQQP---EVEVTHETLQRNR-PDSGVEEAWK 894

Query: 917  LKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
            ++ +L+EE +R  ++++E+++ + ++  LR Q P E +  KEV++   DP LE S  +++
Sbjct: 895  IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQ 954

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
              + EE  +   LQ +LE    ++  LE + +      + KEV ++E D     +  QLR
Sbjct: 955  RTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLR 1014

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALR 1096
             +++ LR +     A +  L++ + AL + +   +EKV  KEVVK++ + ++    Q L+
Sbjct: 1015 EELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQ 1074

Query: 1097 LQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLR 1156
               +     R++ EE ++ LQ +++ LE+  +  E K+ VKEV KVE+D    +E S L 
Sbjct: 1075 EDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLT 1134

Query: 1157 SLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAK 1216
               E+E  K     RE ++L  K   +E++  KV +QE+V EI + DP+ E E+  L+ +
Sbjct: 1135 RQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLE 1194

Query: 1217 LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQ 1276
            L E   K  G E+++     +LE LR + P VE KEVT+EV++++  PE+ +E+ RL+ +
Sbjct: 1195 LVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREE 1254

Query: 1277 LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE 1336
            + +      R   ++ +L+ E    +  + +V+TK V +E+++ ++DP  ++E   LR +
Sbjct: 1255 IVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAK 1314

Query: 1337 VREAAQKR--RAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGS 1394
            + E  +K+     E A  E Q  R   E  + +E+VV QEVV  +++P LR E S  + S
Sbjct: 1315 LSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAES 1374

Query: 1395 LDEEVGRRRQLELEVQQL-RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRP 1453
            +D E+ +  +L  E+++L R   E +  L   + +R  +   ERE+++L  R+  LE+  
Sbjct: 1375 IDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEE 1434

Query: 1454 PTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAK 1513
               +EK+   + V L++DP   +    LR  L++E+ +   L  E + L+ ++  L+KA+
Sbjct: 1435 AEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE 1494

Query: 1514 SQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRT 1573
             +EK +  E ++V+K    E E  R+   L  E  +++  + E  RL  R+         
Sbjct: 1495 VKEKVVLSESVQVEKGDT-EQEIQRLKSSLEEESRSKRELDVEVSRLEARL--------- 1544

Query: 1574 WSREESELQRARDQADQECGRLQQELRALERQKQQ---QTLQLQEESKLLSQKTESER-Q 1629
                 SEL+    ++ +E   L++E   L+ ++Q    +T +LQ E  + + +T   R  
Sbjct: 1545 -----SELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNM 1599

Query: 1630 KAAQRGQELSRLEAAILREKDQI----YEKERTLRDLHAKVSREELSQETQTRETNLSTK 1685
              A  G        ++ RE D +     +K+  + +L  ++    + +E   RE +L   
Sbjct: 1600 TVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE--QRENHLRRS 1657

Query: 1686 ISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGK 1745
            I ++ P+TG+++SP EA++ G+ID   +++L+  ECDWEE++  GP GE SV+ DRKSGK
Sbjct: 1658 IVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGK 1717

Query: 1746 QYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGE 1783
            ++SIE AL+  R++  +Y  Y +  + I E A+LV+G+
Sbjct: 1718 KFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQ 1755


>gi|223468634 envoplakin-like [Homo sapiens]
          Length = 301

 Score =  377 bits (969), Expect = e-104
 Identities = 216/307 (70%), Positives = 232/307 (75%), Gaps = 30/307 (9%)

Query: 46  MQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKAR 105
           MQA+ADQVERDILETQKRLQQDRLNSEQSQALQHQQETG SLKEAEVLLKDLFLDVDKAR
Sbjct: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60

Query: 106 RLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPD------VGPRVDWARVLEQK 159
           RLKHPQAEE EKDI+QLHERVTQECAEY ALYEKMVLPP       +G R   A      
Sbjct: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAG-AETEAGL 119

Query: 160 QKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL--RSLVGPDAATIRSQYRDLLK- 216
           ++ V AG  G G  +   + A+H        A G Q   R+   P  A  R     + + 
Sbjct: 120 RRPVWAGHGGAGGTD---RGAQHR-------AEGDQRPRRAAAEPGGAGCRHHPEPIPRP 169

Query: 217 ------AASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270
                 A +  GQ + +L    QGCT QLSALAEQQRRILQQDWSDLMADPAGVRREYEH
Sbjct: 170 TEGGVVARAEPGQPVHAL----QGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 225

Query: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330
           FKQHELLSQEQSVNQLE+DG+RMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ
Sbjct: 226 FKQHELLSQEQSVNQLEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 285

Query: 331 HVEDYRR 337
           HVEDY R
Sbjct: 286 HVEDYSR 292


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 453

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 454  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 513

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 693  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 753  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 812

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 813  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 872

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 873  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 932

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 933  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 992

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 993  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1051

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1052 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1110

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1291 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1467

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1526

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1701

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1762 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1820

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1992

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2113 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2170 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2224

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2225 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2279

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2280 AARL------SVAAQEAARLRQLAEED 2300



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4121 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4180

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4181 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4240

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4241 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4295

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4296 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4355

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4356 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4415

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4416 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4475

Query: 2023 S 2023
            S
Sbjct: 4476 S 4476



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 992

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 993  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1048

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1228 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1274

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1275 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1304

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1352

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1353 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1407 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1456

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1577 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1634 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1662

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1663 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1714 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1945 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2121

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2302 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2354

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2411

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2467

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2577

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2578 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2680

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2681 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2740

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2741 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2800

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2801 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2860

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2861 NLTYLQLLERCVEDPETGLCLLP 2883



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1629

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1630 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1689 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1796

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1851

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1912 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1969 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1998

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2059 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2224

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2405 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2460

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2461 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2517

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2743

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2744 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2779

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2780 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2838

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2839 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2896

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2897 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2954

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2955 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3009

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 3010 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3069

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3070 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3121

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3122 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3181

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3182 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3241

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3242 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3278

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3279 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3333

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3334 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3392

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3393 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3452

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3453 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3512

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3513 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3542



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1418

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1419 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1463

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1464 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1510

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1630 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1675

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1734

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1793

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1851

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1852 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1970 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 2008

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2042

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2043 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2267

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2268 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2313

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2374 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2433 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2540

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2541 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3935 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3994

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3995 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4054

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4055 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4114

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4115 GLCLLP 4120



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3026 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3085

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3086 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3145

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3146 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3205

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3206 GLSLLPLSEKAAR 3218



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3692 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3751

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3752 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3811

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3812 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3870

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3871 GQLLLP 3876



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3035

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3036 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3095

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3096 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3138



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3647 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3701

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3702 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3761

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3762 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3804



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2200 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2254

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2255 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2358

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2359 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2392

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2438

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2439 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2489

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2663

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2664 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2722 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2773

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2774 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2803



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4107


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 398  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 457

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 458  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 517

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 518  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 577

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 578  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 637

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 638  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 696

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 697  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 756

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 757  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 816

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 817  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 876

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 877  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 936

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 937  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 996

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 997  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1055

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1056 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1114

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1115 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1174

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1175 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1234

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1235 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1294

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1295 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1471

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1530

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1590

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1650

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1705

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1765

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1766 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1824

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1884

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1996

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2117 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2174 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2228

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2229 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2283

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2284 AARL------SVAAQEAARLRQLAEED 2304



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4125 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4184

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4185 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4244

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4245 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4299

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4300 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4359

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4360 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4419

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4420 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4479

Query: 2023 S 2023
            S
Sbjct: 4480 S 4480



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 996

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 997  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1052

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1053 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1231

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1232 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1278

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1279 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1308

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1356

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1357 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1411 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1460

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1581 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1638 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1666

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1667 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1718 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1768

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1949 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2125

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2306 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2358

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2415

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2471

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2581

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2582 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2627

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2628 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2684

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2685 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2744

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2745 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2804

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2805 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2864

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2865 NLTYLQLLERCVEDPETGLCLLP 2887



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1633

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1634 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1693 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1800

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1855

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1915

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1916 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1972

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1973 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 2002

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2063 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2115

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2228

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2409 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2464

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2465 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2521

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2638

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2696

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2697 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2747

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2748 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2783

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2784 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2842

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2843 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2900

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2901 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2958

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2959 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3013

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 3014 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3073

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3074 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3125

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3126 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3185

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3186 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3245

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3246 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3282

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3283 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3337

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3338 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3396

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3397 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3456

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3457 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3516

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3517 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3546



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1422

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1423 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1467

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1468 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1514

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1634 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1679

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1738

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1797

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1855

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1856 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1974 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 2012

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2046

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2047 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2271

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2272 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2317

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2378 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2437 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2490

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2544

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2545 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3939 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3998

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3999 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4058

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4059 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4118

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4119 GLCLLP 4124



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3030 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3089

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3090 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3149

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3150 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3209

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3210 GLSLLPLSEKAAR 3222



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3696 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3755

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3756 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3815

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3816 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3874

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3875 GQLLLP 3880



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2985 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3039

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3040 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3099

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3100 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3142



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3651 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3705

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3706 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3765

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3766 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3808



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2204 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2258

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2259 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2362

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2363 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2396

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2442

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2443 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2493

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2609 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2667

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2668 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2725

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2726 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2777

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2778 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2807



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 4002 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4061

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4062 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4111


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 453

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 454  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 513

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 693  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 753  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 812

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 813  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 872

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 873  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 932

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 933  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 992

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 993  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1051

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1052 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1110

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1291 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1467

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1526

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1701

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1762 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1820

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1992

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2113 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2170 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2224

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2225 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2279

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2280 AARL------SVAAQEAARLRQLAEED 2300



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4121 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4180

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4181 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4240

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4241 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4295

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4296 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4355

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4356 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4415

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4416 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4475

Query: 2023 S 2023
            S
Sbjct: 4476 S 4476



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 992

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 993  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1048

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1228 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1274

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1275 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1304

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1352

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1353 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1407 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1456

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1577 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1634 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1662

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1663 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1714 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1945 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2121

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2302 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2354

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2411

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2467

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2577

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2578 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2680

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2681 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2740

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2741 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2800

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2801 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2860

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2861 NLTYLQLLERCVEDPETGLCLLP 2883



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1629

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1630 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1689 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1796

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1851

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1912 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1969 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1998

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2059 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2224

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2405 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2460

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2461 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2517

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2743

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2744 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2779

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2780 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2838

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2839 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2896

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2897 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2954

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2955 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3009

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 3010 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3069

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3070 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3121

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3122 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3181

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3182 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3241

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3242 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3278

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3279 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3333

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3334 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3392

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3393 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3452

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3453 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3512

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3513 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3542



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1418

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1419 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1463

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1464 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1510

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1630 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1675

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1734

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1793

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1851

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1852 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1970 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 2008

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2042

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2043 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2267

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2268 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2313

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2374 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2433 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2540

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2541 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3935 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3994

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3995 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4054

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4055 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4114

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4115 GLCLLP 4120



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3026 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3085

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3086 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3145

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3146 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3205

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3206 GLSLLPLSEKAAR 3218



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3692 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3751

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3752 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3811

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3812 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3870

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3871 GQLLLP 3876



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3035

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3036 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3095

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3096 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3138



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3647 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3701

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3702 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3761

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3762 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3804



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2200 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2254

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2255 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2358

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2359 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2392

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2438

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2439 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2489

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2663

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2664 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2722 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2773

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2774 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2803



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4107


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 362  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 421

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 422  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 481

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 482  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 541

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 542  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 602  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 660

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 661  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 720

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 721  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 780

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 781  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 840

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 841  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 900

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 901  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 960

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 961  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1019

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1020 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1078

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1079 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1138

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1139 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1198

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1199 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1258

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1259 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1435

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1494

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1554

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1614

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1669

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1729

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1730 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1788

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1848

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1908

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1960

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2081 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2138 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2192

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2193 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2247

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2248 AARL------SVAAQEAARLRQLAEED 2268



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4089 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4148

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4149 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4208

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4209 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4263

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4264 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4323

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4324 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4383

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4384 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4443

Query: 2023 S 2023
            S
Sbjct: 4444 S 4444



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 960

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 961  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1016

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1017 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1195

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1196 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1242

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1243 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1272

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1320

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1321 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1375 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1424

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1545 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1602 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1630

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1631 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1682 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1732

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1913 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2089

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2270 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2322

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2379

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2435

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2545

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2546 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2591

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2592 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2648

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2649 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2708

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2709 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2768

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2769 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2828

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2829 NLTYLQLLERCVEDPETGLCLLP 2851



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1597

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1598 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1657 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1764

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1819

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1879

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1880 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1936

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1937 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1966

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 1967 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2026

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2027 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2079

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2192

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2373 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2428

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2429 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2485

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2602

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2660

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2661 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2711

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2712 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2747

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2748 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2806

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2807 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2864

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2865 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2922

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2923 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 2977

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 2978 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3037

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3038 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3089

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3090 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3149

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3150 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3209

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3210 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3246

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3247 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3301

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3302 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3360

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3361 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3420

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3421 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3480

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3481 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3510



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1386

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1387 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1431

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1432 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1478

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1598 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1643

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1702

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1761

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1819

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1820 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1938 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 1976

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2010

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2011 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2235

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2236 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2281

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2342 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2401 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2454

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2455 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2508

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2509 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3903 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3962

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3963 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4022

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4023 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4082

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4083 GLCLLP 4088



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 2994 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3053

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3054 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3113

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3114 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3173

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3174 GLSLLPLSEKAAR 3186



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3660 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3719

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3720 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3779

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3780 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3838

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3839 GQLLLP 3844



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2949 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3003

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3004 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3063

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3064 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3106



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3615 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3669

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3670 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3729

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3730 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3772



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2168 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2222

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2223 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2326

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2327 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2360

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2406

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2407 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2457

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2573 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2631

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2632 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2689

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2690 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2741

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2742 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2771



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 3966 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4025

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4026 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4075


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 531  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 590

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 591  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 650

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 651  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 710

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 711  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 770

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 771  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 829

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 830  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 889

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 890  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 949

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 950  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 1009

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 1010 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1069

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 1070 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1129

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 1130 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1188

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1189 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1247

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1248 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1307

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1308 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1428 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1604

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1663

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1723

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1783

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1838

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1899 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1957

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 2017

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 2129

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2250 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2307 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2361

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2362 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2416

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2417 AARL------SVAAQEAARLRQLAEED 2437



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4258 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4317

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4318 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4377

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4378 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4432

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4433 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4492

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4493 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4552

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4553 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4612

Query: 2023 S 2023
            S
Sbjct: 4613 S 4613



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 1129

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 1130 --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1185

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1186 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1364

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1365 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1411

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1412 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1441

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1489

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1490 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1544 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1593

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1714 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1771 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1799

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1800 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1851 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1901

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 2082 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2258

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2439 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2491

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2548

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2604

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2714

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2715 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2760

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2817

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2818 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2877

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2878 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2937

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2938 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2997

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2998 NLTYLQLLERCVEDPETGLCLLP 3020



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1766

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1767 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1826 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1933

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1988

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 2048

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 2049 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 2105

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 2106 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 2135

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2196 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2361

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2542 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2597

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2598 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2654

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2829

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2830 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2880

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2881 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2916

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2917 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2975

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2976 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 3033

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 3034 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 3091

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 3092 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3146

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 3147 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3206

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3207 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3258

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3259 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3318

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3319 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3378

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3379 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3415

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3416 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3470

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3471 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3529

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3530 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3589

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3590 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3649

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3650 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3679



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1555

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1556 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1600

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1601 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1647

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1767 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1812

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1871

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1930

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1988

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1989 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 2107 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 2145

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2179

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2180 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2404

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2405 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2450

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2511 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2570 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2623

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2624 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2677

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2678 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 4072 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 4131

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 4132 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4191

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4192 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4251

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4252 GLCLLP 4257



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3163 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3222

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3223 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3282

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3283 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3342

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3343 GLSLLPLSEKAAR 3355



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3829 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3888

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3889 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3948

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3949 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 4007

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 4008 GQLLLP 4013



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 3118 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3172

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3173 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3232

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3233 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3275



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3784 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3838

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3839 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3898

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3899 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3941



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2337 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2391

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2392 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2495

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2496 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2529

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2575

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2576 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2626

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2742 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2800

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2801 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2858

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2859 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2910

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2911 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2940



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4244


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 431

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 432  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 491

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 492  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 552  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 612  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 670

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 671  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 730

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 731  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 790

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 791  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 850

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 851  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 910

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 911  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 970

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 971  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1030 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1088

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1269 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1445

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1504

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1564

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1624

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1679

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1739

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1740 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1798

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1858

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1970

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2091 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2148 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2202

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2203 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2257

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2258 AARL------SVAAQEAARLRQLAEED 2278



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4099 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4158

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4159 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4218

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4219 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4273

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4274 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4333

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4334 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4393

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4394 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4453

Query: 2023 S 2023
            S
Sbjct: 4454 S 4454



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 970

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 971  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1026

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1027 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1205

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1206 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1252

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1253 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1282

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1330

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1331 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1385 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1434

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1555 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1612 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1640

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1641 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1692 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1742

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1923 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2099

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2280 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2332

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2389

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2445

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2555

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2556 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2601

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2602 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2658

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2659 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2718

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2719 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2778

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2779 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2838

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2839 NLTYLQLLERCVEDPETGLCLLP 2861



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1607

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1608 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1667 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1774

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1829

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1889

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1890 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1946

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1947 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1976

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2037 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2202

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2383 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2438

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2439 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2495

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2670

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2671 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2721

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2722 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2757

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2758 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2816

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2817 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2874

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2875 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2932

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2933 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 2987

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 2988 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3047

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3048 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3099

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3100 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3159

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3160 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3219

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3220 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3256

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3257 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3311

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3312 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3370

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3371 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3430

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3431 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3490

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3491 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3520



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1396

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1397 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1441

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1442 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1488

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1608 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1653

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1712

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1771

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1829

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1830 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1948 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 1986

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2020

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2021 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2245

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2246 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2291

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2352 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2411 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2464

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2465 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2518

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2519 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3913 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3972

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3973 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4032

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4033 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4092

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4093 GLCLLP 4098



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3004 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3063

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3064 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3123

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3124 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3183

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3184 GLSLLPLSEKAAR 3196



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3670 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3729

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3730 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3789

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3790 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3848

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3849 GQLLLP 3854



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2959 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3013

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3014 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3073

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3074 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3116



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3625 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3679

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3680 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3739

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3740 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3782



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2178 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2232

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2233 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2336

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2337 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2370

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2416

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2417 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2467

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2583 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2641

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2642 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2699

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2700 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2751

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2752 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2781



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4085


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 380  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 439

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 440  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 499

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 500  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 559

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 560  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 619

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 620  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 678

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 679  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 738

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 739  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 798

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 799  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 858

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 859  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 918

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 919  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 978

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 979  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1037

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1038 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1096

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1097 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1156

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1157 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1216

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1217 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1276

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1277 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1453

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1512

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1572

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1632

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1687

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1747

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1748 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1806

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1866

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1926

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 1978

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2099 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2156 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2210

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2211 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2265

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2266 AARL------SVAAQEAARLRQLAEED 2286



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4107 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4166

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4167 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4226

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4227 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4281

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4282 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4341

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4342 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4401

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4402 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4461

Query: 2023 S 2023
            S
Sbjct: 4462 S 4462



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 978

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 979  --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1034

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1035 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1213

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1214 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1260

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1261 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1290

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1338

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1339 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1393 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1442

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1563 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1620 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1648

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1649 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1700 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1750

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1931 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2107

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2288 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2340

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2397

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2453

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2563

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2564 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2609

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2610 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2666

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2667 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2726

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2727 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2786

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2787 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2846

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2847 NLTYLQLLERCVEDPETGLCLLP 2869



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1615

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1616 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1675 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1782

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1837

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1897

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1898 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1954

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1955 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1984

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 1985 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2044

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2045 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2097

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2210

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2391 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2446

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2447 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2503

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2620

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2678

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2679 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2729

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2730 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2765

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2766 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2824

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2825 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2882

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2883 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2940

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2941 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 2995

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 2996 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3055

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3056 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3107

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3108 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3167

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3168 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3227

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3228 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3264

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3265 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3319

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3320 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3378

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3379 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3438

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3439 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3498

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3499 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3528



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1404

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1405 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1449

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1450 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1496

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1616 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1661

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1720

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1779

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1780 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1837

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1838 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1956 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 1994

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2028

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2029 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2253

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2254 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2299

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2360 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2419 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2472

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2473 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2526

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2527 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3921 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3980

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 3981 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4040

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4041 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4100

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4101 GLCLLP 4106



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3012 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3071

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3072 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3131

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3132 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3191

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3192 GLSLLPLSEKAAR 3204



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3678 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3737

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3738 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3797

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3798 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3856

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3857 GQLLLP 3862



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 2967 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3021

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3022 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3081

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3082 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3124



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3633 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3687

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3688 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3747

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3748 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3790



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2186 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2240

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2241 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2344

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2345 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2378

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2424

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2425 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2475

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2591 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2649

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2650 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2707

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2708 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2759

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2760 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2789



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 3984 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4043

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4044 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4093


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  356 bits (914), Expect = 1e-97
 Identities = 465/1947 (23%), Positives = 826/1947 (42%), Gaps = 263/1947 (13%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 421  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 481  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 541  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 601  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 661  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 719

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 720  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 779

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 780  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 839

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 840  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 899

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 900  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 959

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 960  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1019

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 1020 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1078

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1079 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1137

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1138 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1197

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257

Query: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317

Query: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQL-EFARKMLEKK 888
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q ++ + E  R+M E++
Sbjct: 1318 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375

Query: 889  ELSEDIR----------------RTHDAKQGSESPAQAGRESEALKAQLEEE--RKRVAR 930
             L+E  R                +   A+  +++ AQA RE++ L+ +++EE  R+  A 
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435

Query: 931  V--QHELEAQRSQLLQLRTQRPLE---RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR 985
            V  Q +  + + +L QLR     E   +  + E  E  R  ++E  +  V+ Q+E   ++
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQ 1494

Query: 986  RAGLQADL--------EVAAQK------------VVQLESKRKTMQPHLLTKEVTQVERD 1025
            R G + +L        E  AQK             VQ ES+RK      L   V + E +
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAE 1553

Query: 1026 PGLDSQAAQLRIQIQQLRGEDA---VISARLEGLKKELLALEKREVDVKEKVVVKEVVKV 1082
               + Q A   ++  +L+ E+A   +  A +E  ++  +ALE  +   + ++  K     
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1613

Query: 1083 EKNLEMVKAAQALRL---QMEEDAARRKQAEEAVAKLQARIE-DLER-AISSVEPKVIVK 1137
            EK  ++ ++ Q   +   Q+ E+A RR Q +    + +   E +LER  + + E   +  
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1673

Query: 1138 EVKKVEQDPGLLQ-ESSRLRSLLEEERTK------NATLARELSDLHSKYSVVEKQRPKV 1190
            + ++V Q   L Q E+ + +   E E  +       A   REL++       +EKQR   
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE-----QELEKQRQLA 1728

Query: 1191 Q--LQERV---HEIFQVDPETEQ----------EITRLKAKLQEMAGKRSGVEKEVEKLL 1235
            +   Q+R+    E+ ++  ETEQ          E+ RL+ +      KR  +E E+ K+ 
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1788

Query: 1236 PDLEVLRAQKPTVEYK-EVTQEVVRHERSPEV--LREIDRLKAQLNELVNSHGRSQEQLI 1292
             ++EVL A K   E +   T E  +     E    RE+    A+L  L     + Q QL 
Sbjct: 1789 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA-EEAKRQRQLA 1847

Query: 1293 RLQGERDEWRRERAKVETKTVSKEVVRHEKDPVL---EKEA--ERLRQEVR-EAAQKRRA 1346
                 R     ER   E      E  R + +  +   EKEA  ERLR+    EA Q+RR 
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1907

Query: 1347 AEDAVYELQ--SKRLLLERRKPEEKVVVQEVVV---TQKDPKLREEHSRLSGSLDEEVGR 1401
             E A        +RL   R+  + ++  Q+ +V    ++  ++ EE   L  S ++    
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967

Query: 1402 RRQLELEVQQLRAGVEE---QEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
            + +LELE+ ++R+  E+    +     +  R ++LA E E R+     +E E+R   VQ+
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR-----REAEER---VQK 2019

Query: 1459 KIIMEEVVKLEKDPDLE---------KSTEALRWDLDQEKTQVTELNRECKNLQVQID-- 1507
             +  EE    ++   LE         +    LR   +QE  +  +L +E    ++Q +  
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079

Query: 1508 -----VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-----MLNRERTARQARE--E 1555
                 V QK +  ++T+ +E   + + R   +   R  E      +  ER A Q+R   E
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139

Query: 1556 EARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE 1615
            EA RL++    AE   +  ++ ++  ++ R +A+QE  R  Q  +A  RQKQ    ++++
Sbjct: 2140 EAERLKQ---SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196

Query: 1616 ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQET 1675
              K   Q   + RQK AQ  QEL+ L   +     Q    +  L+ L A+ + E   Q +
Sbjct: 2197 HKKFAEQ---TLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRS 2251

Query: 1676 QTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE 1735
            Q  E   S ++ +   E  K  +  EA  R +I R +    + L+   EE        EE
Sbjct: 2252 QVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEE 2306

Query: 1736 SVLLDRKSGKQYSIEAALRCRRISKEE 1762
            +  L        + + A R R++++E+
Sbjct: 2307 AARL------SVAAQEAARLRQLAEED 2327



 Score =  264 bits (675), Expect = 6e-70
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 4148 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4207

Query: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 4208 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4267

Query: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 4268 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4322

Query: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 4323 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4382

Query: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 4383 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4442

Query: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 4443 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4502

Query: 2023 S 2023
            S
Sbjct: 4503 S 4503



 Score =  252 bits (643), Expect = 3e-66
 Identities = 483/2123 (22%), Positives = 863/2123 (40%), Gaps = 350/2123 (16%)

Query: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
            R  QD         L  ++E G      + LL+ L     +  R +   +E   KDI   
Sbjct: 965  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISEL--KDI--- 1019

Query: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWA-RVLEQKQKQVCAGQYGPGMAELEQQIAE 181
              R+  E  E R ++ ++ LP D  P  + A R+ EQ++ Q      G G+A L  + AE
Sbjct: 1020 --RLQLEACETRTVH-RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE-AE 1075

Query: 182  HNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSA 241
              +   E       LRS +      +  Q R L      + +++  +    QG    L A
Sbjct: 1076 KVLALPEPSPAAPTLRSELELTLGKLE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134

Query: 242  LAEQ--QRRILQQDWSDLMADPAGVR--REYEHFKQHELLSQEQSVNQLEDDGERMVELR 297
              EQ  + + +     +L A  A ++  R     +Q    +    +   ++ GER+ +  
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194

Query: 298  HPAVGPIQAHQEALKM---EWQNFLNLCICQETQLQHV-EDYRRFQEEADSVSQTLAKLN 353
                  ++  +E +      WQ  L     ++ +L+ +    R ++E AD +   L    
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1254

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
               + +    P     A  E L+Q +A  + +        + QR ++             
Sbjct: 1255 RRQE-QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ------------ 1301

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
               ++++I D+   E+QL+                        T +A       PA  P 
Sbjct: 1302 ---YINAIKDY---ELQLV------------------------TYKAQLEPVASPAKKPK 1331

Query: 474  AVARASRLASELQALK---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
              + +  +  E   L+    +L T+ S+      E+LR  ++            ++ L +
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE------------EERLAE 1379

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSH-EGTAQRLQSLGTEKETAQKE 589
              R +      ER+ LA   A L +   L +   +  +  E  A+ LQ    E+   ++E
Sbjct: 1380 QQRAE------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433

Query: 590  C--EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRV 647
               +A    R +     QL         + S+ ++       +A+AA     +I++  RV
Sbjct: 1434 AAVDAQQQKRSIQEELQQL--------RQSSEAEIQAK--ARQAEAAERSRLRIEEEIRV 1483

Query: 648  IR-GFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAA 705
            +R   EAT  Q      E  AL+ R  E + Q+R+  E+   + R +    +    A   
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543

Query: 706  LQNNFQEFCQDLPRQQRQVRALTD-RYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSS 764
            L +  +   +    +QR ++AL + R  A   +  LR+  V+ A       +  + +  +
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603

Query: 765  WLEHLPRSQVRPSDGPSQIAYKLQ----AQKRLTQEIQSRERDRATASHLSQALQAALQD 820
             L+    S    +   +Q+   LQ    A  +L +E + R + +A A    +  +  L+ 
Sbjct: 1604 ELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660

Query: 821  YELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEF 880
            ++L+A+                      L+  +QA+E            AQQ+ L Q E 
Sbjct: 1661 WQLKANE--------------------ALRLRLQAEE-----------VAQQKSLAQAEA 1689

Query: 881  ARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS 940
             +   +K+E   + RR   A++      QA R+ E  + +LE++R+       +  A   
Sbjct: 1690 EK---QKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740

Query: 941  QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADL-EVAAQK 999
            +L++LR +   E+ E++  +       LE  L+R++ +     ++R  L+A+L +V A+ 
Sbjct: 1741 ELIRLRAET--EQGEQQRQL-------LEEELARLQREAAAATQKRQELEAELAKVRAEM 1791

Query: 1000 VVQLESKRKTMQPHLLTKEVTQ--VERDPG----LDSQAAQLRIQIQ------QLRGEDA 1047
             V L SK +  +    T E ++  +E + G    L  +AA+LR   +      QL  EDA
Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851

Query: 1048 VIS-ARLEGLKKELLAL--EKREVDVKEKVVVKEVVKVEKNLEMVKAAQAL-RLQMEEDA 1103
                A  E +  E LA   E   +  + ++ +KE     + L  +   +A  R ++EE A
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911

Query: 1104 ARRK-QAEEAVAKLQAR-----------IEDLERAISSVEPKVIVKEVKKVEQDPGLLQ- 1150
            A+ K   EE +A+L+             +ED  R    VE +++  +    +   G  + 
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971

Query: 1151 --ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETE- 1207
              E  R+RS  E+  T  +    EL     +    E++R + + +ERV +    + E   
Sbjct: 1972 ELELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029

Query: 1208 ------QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261
                  +E+ RLKAK++E    R   E+E  + L   +    ++   E K     V + E
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089

Query: 1262 RS-PEVLREIDRLKAQLNELVNSHGRSQEQL--IRLQGERDEWRRERAKVETKTVSKEVV 1318
            +   + L++   +  QL     +  R+ E+    R+Q ER E  + R +VE     K+  
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEEAERLKQSA 2148

Query: 1319 RHEKDPVLEKEA--ERLRQEV-REAAQKRRAAEDAVYELQSKRLLLERRKP-EEKVVVQE 1374
              +     + +A  E+LR+E  +EAA++ +A + A+ + Q+    +E+ K   E+ + Q+
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208

Query: 1375 VVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK 1431
              V Q+   LR   EE       LDEE+ R +    E  + R+ VEE+   +  Q +   
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268

Query: 1432 KLA--VERELRQLTLRI---------QELEKRPPTVQE----KIIMEEVVKLEK--DPDL 1474
            KL   +E E R L LR          +E EK     +E     +  +E  +L +  + DL
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328

Query: 1475 EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD----- 1529
             +   AL   + +EK Q  +   E   L+ + ++LQ+   Q++   ++  R+Q+D     
Sbjct: 2329 AQQ-RALAEKMLKEKMQAVQ---EATRLKAEAELLQQ---QKELAQEQARRLQEDKEQMA 2381

Query: 1530 -----------RVLEDERARVWEMLNR---------ERTARQAR-EEEARRLRERIDRAE 1568
                       R LE ER R  EM            E +  QAR EE+A+R R++   AE
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ---AE 2438

Query: 1569 TLGRTWSREE----------SELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESK 1618
             +G    R E            L+  R Q+D +  RL++ +  LER+K++    LQ+E+K
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK----LQQEAK 2494

Query: 1619 LLSQKTES-ERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR---EELSQE 1674
            LL  K+E  +  +  Q  QE   L+ + L EKD + ++ER +    AK+ +   +E+++ 
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554

Query: 1675 TQTRETNLSTKISILEPETGKDMSPYEAYKR------GIIDRGQYLQLQELECDWEEVTT 1728
             Q RE     +  + +       S  EA +R      G+  R +  +LQ+LE        
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV--RRKQEELQQLE-------- 2604

Query: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH-LPISEFALLVAGETKPS 1787
                        R+  ++   E   R R    E+  L ++ H   ++    + A +   +
Sbjct: 2605 ----------QQRRQQEELLAEENQRLR----EQLQLLEEQHRAALAHSEEVTASQVAAT 2650

Query: 1788 SSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAK 1847
             +L  G      P A   P+ +          +       AGI       + +       
Sbjct: 2651 KTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2707

Query: 1848 NMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIE 1907
             +      +  L+ +++  G++   + E+ SV+ A++R L+   +   LL AQ A   + 
Sbjct: 2708 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLL 2767

Query: 1908 DPVTKKRLSVGEAV--------------------------------------QKGWMPRE 1929
            DPV  +RL+V EAV                                      QKG + RE
Sbjct: 2768 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVRE 2827

Query: 1930 SVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKE 1989
              +  L+ Q  TGG+IDP  + R+P+  A   G   EE+ ++L D S   K   DP + E
Sbjct: 2828 HGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHE 2887

Query: 1990 RLSYKEAMGRCRKDPLSGLLLLP 2012
             L+Y + + RC +DP +GL LLP
Sbjct: 2888 NLTYLQLLERCVEDPETGLCLLP 2910



 Score =  215 bits (548), Expect = 3e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1656

Query: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 1657 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715

Query: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 1716 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774

Query: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1823

Query: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1878

Query: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1938

Query: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 1939 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995

Query: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 1996 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 2025

Query: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 2086 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198

Query: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2251

Query: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311

Query: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371

Query: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431

Query: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 2432 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2487

Query: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 2488 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2544

Query: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601

Query: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661

Query: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2719

Query: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 2720 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2770

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 2771 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2806

Query: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 2807 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2865

Query: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 2866 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2923

Query: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 2924 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2981

Query: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 2982 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3036

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 3037 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3096

Query: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 3097 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3148

Query: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 3149 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3208

Query: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 3209 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3268

Query: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 3269 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3305

Query: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 3306 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3360

Query: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 3361 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3419

Query: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 3420 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3479

Query: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 3480 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3539

Query: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 3540 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3569



 Score =  134 bits (337), Expect = 9e-31
 Identities = 300/1413 (21%), Positives = 565/1413 (39%), Gaps = 204/1413 (14%)

Query: 33   RAATQELALLISRMQANAD-----QVERDILETQKRLQQDRLNSEQSQALQHQQETGRSL 87
            R A  E AL   R  A A      Q ER+  E Q+R+Q++ +  E++     QQ+  RS+
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK--RSI 1445

Query: 88   KEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG 147
            +E    L+ L    +   + K  QAE  E+   ++ E +     +  A            
Sbjct: 1446 QEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------------ 1490

Query: 148  PRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATI 207
                      ++Q+    G+     A  E+  A+    Q+E     ++LR  V  ++   
Sbjct: 1491 ---------TERQRGGAEGELQALRARAEEAEAQKRQAQEE----AERLRRQVQDESQRK 1537

Query: 208  RSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRRE 267
            R    +L        ++       LQ    +L   AE+  R L+Q   +           
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQ-ALEELRLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 268  YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPI----------QAHQEALKMEWQN 317
             +   + EL S+  S  +     ER ++  H AV  +          QA  E  + E + 
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 318  FLNLCICQETQLQHVEDYR-RFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQ 376
             L     +  QL+  E  R R Q E  +  ++LA+  +    +          A  E  +
Sbjct: 1657 EL-----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARR 1702

Query: 377  QLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEV--QLLQG 434
            + +AEE+ +   E A  +L+++ +      Q+R   +Q L +    + + GE   QLL+ 
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEE 1761

Query: 435  ERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALK----- 489
            E  +L           Q    E  +  A    + A    A    SR  SE    +     
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA-EEESRSTSEKSKQRLEAEA 1820

Query: 490  ---QKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVL 546
               ++LA   +RL+A A E+ R  Q A   +     +A+++L +     G+  +++ +  
Sbjct: 1821 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-- 1878

Query: 547  AWARAPLSRPTPLEDLEGRIHSHEG-TAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQ 605
              A   L       +   R+   E    +RL+    + +   +E  A L          Q
Sbjct: 1879 --AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
              +  ++++ +    + + +L     KAA        +  R+    E TL  +     E 
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996

Query: 666  GALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVR 725
               ++  +E +R+RRE  E      R+ ++L A E A                RQ++   
Sbjct: 1997 ARQRQLAAEEERRRREAEE------RVQKSLAAEEEAA---------------RQRKAAL 2035

Query: 726  ALTDRYHA-VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIA 784
               +R  A V +   LRE+  Q++A   Q  +                            
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEA-------------------------- 2069

Query: 785  YKLQAQKRLTQEIQSRERDRATA-SHLSQALQAALQDYELQADTYRCSLEPT-LAVSAPK 842
                AQKRL    Q+ E+  A A     Q LQ  LQ  +   D  R   E    A    +
Sbjct: 2070 ----AQKRL----QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 843  RPRVAPLQESIQAQEK-NLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAK 901
              RV   +E+ Q++ +   A+   + A  Q Q   Q + A + L K+   E  RR    +
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181

Query: 902  QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR-----PLERLEE 956
                    A  E E  K   E+  ++ A+V+ EL   R QL +   Q+      L+RL+ 
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241

Query: 957  KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
            +      +  Q+E  L  V+ Q+EE  K +A ++A+      + + L  K  T +   L 
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE-----NRALILRDKDNTQR--FLQ 2294

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
            +E  ++++   +  +AA+L +  Q+        +ARL  L +E LA ++    + EK++ 
Sbjct: 2295 EEAEKMKQ---VAEEAARLSVAAQE--------AARLRQLAEEDLAQQRA---LAEKMLK 2340

Query: 1077 KEVVKVEKNLEMVKAAQALRLQME--EDAARRKQ--AEEAVAKLQARIEDLERAISSVEP 1132
            +++  V++   +   A+ L+ Q E  ++ ARR Q   E+   +L    +  +R + +   
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 1133 KVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSD-LHSKYSVVEKQRPKVQ 1191
            + +     + E+    + E SR ++  EE+  +    A E+ + LH      +++   VQ
Sbjct: 2401 RQLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459

Query: 1192 LQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRA--QKPTVE 1249
              E   +      +++ +  RL+  + E+  ++  +++E + L    E ++   Q+  ++
Sbjct: 2460 TLEIQRQ------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2513

Query: 1250 YKEVTQEVVRHERSPEVLRE--IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAK 1307
              +  Q+    E+   + RE  I++ KA+L +L       Q+++ + Q  R+E +R++ +
Sbjct: 2514 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF------QDEVAKAQQLREEQQRQQQQ 2567

Query: 1308 VETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLE-RRKP 1366
                              +E+E +RL   + EA +++  AE+ V   Q +   LE +R+ 
Sbjct: 2568 ------------------MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609

Query: 1367 EEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV 1399
            +E+++ +E    ++  +L EE  R + +  EEV
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642



 Score =  132 bits (331), Expect = 4e-30
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 3962 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 4021

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 4022 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4081

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 4082 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4141

Query: 2007 GLLLLP 2012
            GL LLP
Sbjct: 4142 GLCLLP 4147



 Score =  127 bits (320), Expect = 8e-29
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 3053 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3112

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 3113 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3172

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 3173 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3232

Query: 2007 GLLLLPAALEGYR 2019
            GL LLP + +  R
Sbjct: 3233 GLSLLPLSEKAAR 3245



 Score =  121 bits (304), Expect = 6e-27
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 3719 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3778

Query: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 3779 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3838

Query: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 3839 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3897

Query: 2007 GLLLLP 2012
            G LLLP
Sbjct: 3898 GQLLLP 3903



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 3008 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3062

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 3063 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3122

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 3123 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3165



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 3674 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3728

Query: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 3729 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3788

Query: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
                       DP +++ +S  +AM +        L LL A L
Sbjct: 3789 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3831



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 147/752 (19%), Positives = 274/752 (36%), Gaps = 130/752 (17%)

Query: 25   KGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG 84
            K +    +R A  E A L  +  A+A+  +      Q   Q+ ++  E +      +ET 
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPP 144
                  +  L+ L  +  +A R    Q  ++E+++  +  ++ +E ++ +A  E      
Sbjct: 2227 HQKNLLDEELQRLKAEATEAAR----QRSQVEEELFSVRVQM-EELSKLKARIEAENRAL 2281

Query: 145  DVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDA 204
             +  + +  R L+++             AE  +Q+AE             +LR L   D 
Sbjct: 2282 ILRDKDNTQRFLQEE-------------AEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328

Query: 205  ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGV 264
            A  R+    +LK      Q    L    +   +Q   LA++Q R LQ+D   +    A  
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLA-- 2385

Query: 265  RREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCIC 324
              E + F++            LE + +R +E+         A  E LK      L +   
Sbjct: 2386 -EETQGFQR-----------TLEAERQRQLEM--------SAEAERLK------LRVAEM 2419

Query: 325  QETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKR 384
               Q +  ED +RF+++A+ + + L +       K +            L+Q LE +   
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT------------LVQTLEIQR-- 2465

Query: 385  LAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT- 443
                +++  D +R    +A L + +   QQ      +    S E+Q +Q E  +L+  T 
Sbjct: 2466 ----QQSDHDAERLREAIAELEREKEKLQQEA---KLLQLKSEEMQTVQQE--QLLQETQ 2516

Query: 444  --------DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
                    +  + + +    E ++A      +     D VA+A +L  E Q  +Q++   
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAK-----LEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571

Query: 496  QSRLKASAVESLRPSQQAPSG------------------SDLANPQAQKLLTQMTRLD-- 535
            + RL AS  E+ R   +A  G                   +L   + Q+L  Q+  L+  
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631

Query: 536  --GDLGQIERQVLAWARAPLSRPTPLEDLEGRI------HSHEG-----TAQRLQSLGTE 582
                L   E    +   A  + P   + L+G        HS +G     +AQRLQ  G  
Sbjct: 2632 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI- 2690

Query: 583  KETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQ 642
               + +E +             +     + ++ + S   +L     EK      L+RQ+ 
Sbjct: 2691 --LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2748

Query: 643  DADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHA 702
                 +   EA         A  G L + V   +    E +++      LH  L ++E A
Sbjct: 2749 SPGTALILLEA--------QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERA 2800

Query: 703  CAALQNNFQEFCQDLPRQQRQVRALTDRYHAV 734
                ++ +    Q +   Q   + L  R H +
Sbjct: 2801 VTGYKDPYTG--QQISLFQAMQKGLIVREHGI 2830



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 4025 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4084

Query: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 4085 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4134


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  307 bits (786), Expect = 8e-83
 Identities = 428/2096 (20%), Positives = 851/2096 (40%), Gaps = 301/2096 (14%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 289  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 348

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 409  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 468  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 527

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 528  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 588  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 648  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 708  ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 768  LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 947  NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1065

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPA 908
              + I  +  +L   YT +      + Q ++FA   L++ E  E  R    ++ G+ S  
Sbjct: 1066 SADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122

Query: 909  QAGRESEALK-AQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQ 967
               +++  L+ ++L  +   + R+  EL+ Q+S     R +  L ++ E    E  +  +
Sbjct: 1123 LQRQKATVLENSKLTGKISELERMVAELKKQKS-----RVEEELPKVREAAENELRKQQR 1177

Query: 968  LEGSLSRVKAQVEEEGKR-----------RAGLQADLEVAAQKVVQLESKRKTMQPHLLT 1016
                +S  K + E E K+           +   + +LE   Q  ++ E+KR  ++ +LL 
Sbjct: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237

Query: 1017 KEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                       L+      R     L+ +D  ++  LE  K +L+   +R+ D  E+ ++
Sbjct: 1238 FR-------NQLEENTFTRRTLEDHLKRKDLSLN-DLEQQKNKLMEELRRKRD-NEEELL 1288

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136
            K + ++EK+L   K  Q    Q++E      +A   + ++Q    +    +  +      
Sbjct: 1289 KLIKQMEKDLAFQK--QVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSC 1346

Query: 1137 KEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERV 1196
            + V  ++Q+    Q++  L+  ++E    N    +++ +L   Y +   Q  K   +E+ 
Sbjct: 1347 RAVTGLQQEHD-KQKAEELKQQVDELTAANRKAEQDMREL--TYELNALQLEKTSSEEKA 1403

Query: 1197 HEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVL--RAQKPTVEYKEVT 1254
              +     ET   +  LK +L+       G  +++ +L   L     +A++   E  ++ 
Sbjct: 1404 RLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 1463

Query: 1255 QEVVRHERSPEVL-REIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            +    ++   E L  E  +L+ +++ +  +H  +++ +  L  +   +R E+ ++E   +
Sbjct: 1464 KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK-ELERLQI 1522

Query: 1314 SKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQ 1373
             +    H K+   EK  E+L Q ++   +     +    EL+      E  K +    V+
Sbjct: 1523 CQRKSDHLKEQ-FEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQK----VE 1577

Query: 1374 EVVVTQKDPKLREEHSRLSGS---LDEEVGRRRQLELEVQ------QLRAGVEEQEGLLS 1424
            E+     + KL  +  +       L+++  ++R   L++Q      QLR+  E       
Sbjct: 1578 ELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637

Query: 1425 FQEDRSKKL-AVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK--DPDLEKSTEAL 1481
             ++D  +K+  +E +L +    + E +++    Q+ II++   K  +  + +L  S E  
Sbjct: 1638 TEQDFQRKIKCLEEDLAKSQNLVSEFKQK--CDQQNIIIQNTKKEVRNLNAELNASKEEK 1695

Query: 1482 R---WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD-----RVLE 1533
            R     +  ++ QV ELN   K +Q   D L     +E+  +++++  Q++     +  E
Sbjct: 1696 RRGEQKVQLQQAQVQELNNRLKKVQ---DELHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752

Query: 1534 DERARVWEMLNRE----------RTARQAREEEARRLRERIDRAETLGRTWSREESELQR 1583
            + R ++ +++  +          R    + ++E  R +E     ET        E +LQ+
Sbjct: 1753 EFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCET---NIKELERQLQQ 1809

Query: 1584 ARDQAD----------QECGRLQQEL----RALERQKQQQTLQLQE-ESKLLSQKTESER 1628
             R+Q            Q+C +L+ EL    R +E  KQ+   Q++E E +L+  + E ++
Sbjct: 1810 YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869

Query: 1629 Q----------------KAAQRGQELS------------------RLEAAILREKDQIYE 1654
            +                K  Q   ELS                    E   L EK Q   
Sbjct: 1870 KSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV 1929

Query: 1655 KERTLRDLH-----AKVSREELSQETQTRETNLSTKISILEPETG--KDMSPYEAYKRGI 1707
             E+  +++      A + +E+  Q      +  ST++ I   ET     +S  E  +   
Sbjct: 1930 VEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQA 1989

Query: 1708 IDRGQ-YLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLY 1766
            ++  +  ++ Q+  C+ E V    P       L+    KQY +   +   +  K      
Sbjct: 1990 LNNSRPPVRYQDNACEMELVKVLTP-------LEIAKNKQYDMHTEVTTLKQEKNP---- 2038

Query: 1767 KDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFP 1826
                +P +E  +L     + S  L  G  + K       P++   F    +  + DD F 
Sbjct: 2039 ----VPSAEEWMLEG--CRASGGLKKGDFLKK----GLEPETFQNFDGDHACSVRDDEFK 2088

Query: 1827 IAGIYDTTTD-------------------------------NKCSIKTAVAKNMLDPITG 1855
              G+  T T                                NK   K      +    T 
Sbjct: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTK 2148

Query: 1856 QKLLEAQAATGGIVDL-------------------LSRERYSVHKAMERGLIENTSTQRL 1896
            +K+  A AA   I+D                    +S + YSV  A+ +G+++     RL
Sbjct: 2149 EKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208

Query: 1897 LNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQ 1956
            L A+KA  G     + K LSV +A++   + R+     L+ Q  +GG+IDP R  R+P +
Sbjct: 2209 LEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPE 2266

Query: 1957 QALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             AL  G+++  + Q L + SS  +   +P +K+ L Y E +  C  D  S   L P
Sbjct: 2267 IALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFP 2322



 Score =  192 bits (489), Expect = 2e-48
 Identities = 331/1575 (21%), Positives = 647/1575 (41%), Gaps = 250/1575 (15%)

Query: 611  NSVKNKFSDVQ-VLCSLYGEKAKAALDLERQIQDADRVIRGFEATL--VQEAPIPAEPGA 667
            + +  K S+++ ++  L  +K++   +L +  + A+  +R  +  +  +    I AE  A
Sbjct: 1134 SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEA 1193

Query: 668  LQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRAL 727
             Q R  EL+   RE    +  + R+ +    +E   AA++ N   F   L       R L
Sbjct: 1194 KQYR-RELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252

Query: 728  TDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPR--------SQVRPSDG 779
             D  H     L L +   Q   L  ++ +  +DN    L+ + +         QV     
Sbjct: 1253 ED--HLKRKDLSLNDLEQQKNKLM-EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQL 1309

Query: 780  PSQIAYKLQAQKRLTQEIQSRERDRA------TASHLSQALQAALQDYELQ-ADTYRCSL 832
              +   +L+A++++T EIQ   R+ A      T +   +A+    Q+++ Q A+  +  +
Sbjct: 1310 KEKQKIELEARRKIT-EIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQV 1368

Query: 833  EPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQ--------QLEFARKM 884
            +   A +      +  L   + A +     +  +    + +L +        +LE  RK 
Sbjct: 1369 DELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKD 1428

Query: 885  LEKKELSEDIR-----------RTHDAKQGSESPAQAGR----ESEAL---KAQLEEERK 926
              +K  S+ +R           +  +A Q +    +  R    E E+L   K +L+ E  
Sbjct: 1429 QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVD 1488

Query: 927  RVARV----QHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGS----LSRVKAQ 978
            R+ R     +  ++   SQ+   R ++ LERL+  +    +   Q E S    L  +KA+
Sbjct: 1489 RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAE 1548

Query: 979  VEEEGKRRAGLQADLEVAAQKVVQLESK-----RKTMQPHLLTKEVTQVERDPGLDSQAA 1033
             E   K +  L  +LE + +    L+ K     R+  +  L+ + +     +  L+ Q  
Sbjct: 1549 KENNDKIQR-LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTI 1607

Query: 1034 QLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKV-VVKEVVKVEKNL------ 1086
            Q R +  +++ +      +L    + L    K E D + K+  ++E +   +NL      
Sbjct: 1608 QQRCEALKIQADG--FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665

Query: 1087 ----------EMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136
                         K  + L  ++      +++ E+ V   QA++++L   +  V+ ++ +
Sbjct: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725

Query: 1137 KEVKK---------VEQDPGLLQESS-----RLRSLLE-------------------EER 1163
            K +++          +++ G  ++S+     ++  L+E                   ++ 
Sbjct: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQE 1785

Query: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVH---EIFQVDPETEQEITRLKAKLQEM 1220
               A    +L + + K    + Q+ + Q+Q+  H     +Q   + E E+   K +++ +
Sbjct: 1786 NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENL 1845

Query: 1221 AGKRSGVEKEVEKLLPDLEVLRAQKPTVE---YK---EVTQEVVRHE------------- 1261
              K     KE E  L  L+    +K T +   +K   E+T +  +H              
Sbjct: 1846 KQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHP 1905

Query: 1262 ----------RSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETK 1311
                      + P+ L E  + + ++ E +    + Q     L+ E+ +        +T 
Sbjct: 1906 TPRSPLLRWTQEPQPLEE--KWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTS 1963

Query: 1312 TVSKEVVRHEKDPVLE-KEAERLRQEVREAAQKRRAAEDAVYELQSKRLL--LERRKPEE 1368
            T   ++   E +P+    E E++R +    ++     +D   E++  ++L  LE  K ++
Sbjct: 1964 T-ELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQ 2022

Query: 1369 KVVVQEVVVTQKD----PKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEG 1421
              +  EV   +++    P   E   E  R SG L +    ++ LE E  Q   G    + 
Sbjct: 2023 YDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDG----DH 2078

Query: 1422 LLSFQEDRSK----------------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEV 1465
              S ++D  K                KL   R + QL L ++ +E+   T+ + +     
Sbjct: 2079 ACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATS 2138

Query: 1466 VK---LEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE 1522
            +    LE   +      A    +  +   +  L  +     +   +  +  S E  + K 
Sbjct: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198

Query: 1523 VIRVQ-KDRVLEDERARV-WEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESE 1580
            V+  + + R+LE E+A V +   ++  +  QA E               L R   +   E
Sbjct: 2199 VVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRM------------LDRQKGKHILE 2246

Query: 1581 LQRARDQA-DQECG-RLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQEL 1638
             Q A     D   G R+  E+   +       LQ   E    ++   +   K A    EL
Sbjct: 2247 AQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSEL 2306

Query: 1639 SRLEAAILREKDQIYE-KERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDM 1697
             R+    +  +  ++   ER + +L+ K +                 +IS+++ +TG ++
Sbjct: 2307 LRMCVFDVESQCFLFPFGERNISNLNVKKTH----------------RISVVDTKTGSEL 2350

Query: 1698 SPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEES-VLLDRKSGKQYSIEAALRCR 1756
            + YEA++R +I++  YL+L   +  W+E       G  S +L D K+G  ++I  A+   
Sbjct: 2351 TVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQG 2410

Query: 1757 RISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSPSF 1816
             I K     Y++G + ++E A           SL +  ++ K  L S             
Sbjct: 2411 TIDKALVKKYQEGLITLTELA----------DSL-LSRLVPKKDLHS------------- 2446

Query: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876
                     P+AG + T +  + S+  A  +N++D IT  + LEAQ +TGGI+D L+ ++
Sbjct: 2447 ---------PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497

Query: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936
            Y V +A+ RGL++    Q+L   +   TGI  P+T K +SV EAV    + +E  +  L+
Sbjct: 2498 YRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLE 2557

Query: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996
             Q+LTGGLI+P+   R+ I++AL  G+I   +A  L+D+ SY +++  P +K +L+YKEA
Sbjct: 2558 FQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEA 2617

Query: 1997 MGRCRKDPLSGLLLL 2011
            + +   D  +GL LL
Sbjct: 2618 LEKADFDFHTGLKLL 2632



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  243 bits (620), Expect = 1e-63
 Identities = 147/378 (38%), Positives = 224/378 (59%), Gaps = 19/378 (5%)

Query: 1655 KERTLRDLHAKVSR---EELSQETQTRETNLSTK--ISILEPETGKDMSPYEAYKRGIID 1709
            KER ++D    +     +E  ++ QT + N   K  + I++PET K+MS  EAYK+G+ID
Sbjct: 1831 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 1890

Query: 1710 RGQYLQLQELECDWEEVTTSGPCGEESVLL-DRKSGKQYSIEAALRCRRISKEEYHLYKD 1768
               + +L E EC+WEE+T +G  G   V+L DRK+G QY I+ A+    + ++ +  Y+ 
Sbjct: 1891 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 1950

Query: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP------------SF 1816
            G L +++FA +++ +    +S S+GS +S    +S   +S S  S             SF
Sbjct: 1951 GSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSF 2010

Query: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876
            S  L ++S PIA I+DT    K SI   + + ++D ITGQ+LLEAQA TGGI+   + ++
Sbjct: 2011 SDTL-EESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069

Query: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936
             S+  A+ +G+I+     RL  AQKAF G E    KK++S  EAV++ W+P E+    L+
Sbjct: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129

Query: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996
             Q+LTGGL+DP+  GRI  ++A+  G I    AQ LQD SSY K LT P +K ++SYK+A
Sbjct: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDA 2189

Query: 1997 MGRCRKDPLSGLLLLPAA 2014
            + R   + ++GL LL AA
Sbjct: 2190 INRSMVEDITGLRLLEAA 2207



 Score =  176 bits (446), Expect = 2e-43
 Identities = 267/1129 (23%), Positives = 495/1129 (43%), Gaps = 141/1129 (12%)

Query: 953  RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQP 1012
            RL E+E V    D ++E     +K +++ +   +  L A ++   QK  Q+ S+     P
Sbjct: 790  RLTEEETVCLDLD-KVEAYRCGLK-KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYP 847

Query: 1013 HL------LTKEVTQVER-----DPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
                      ++VTQ+       D  +D +   L  QI+QLR             +    
Sbjct: 848  LYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRN-----------YRDNYQ 896

Query: 1062 ALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA--VAKLQAR 1119
            A  K   D K +    E +K   +  +++     +    E + +R ++EE   +A+L A 
Sbjct: 897  AFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCAN 956

Query: 1120 -IEDLERAISS----VEPKVIVKEVKKVEQDPG--LLQESSRLRSLLEEERTKNATLARE 1172
             I+D E  ++S    +E  + +   + + Q P   +LQE++ + +   E  T++    R 
Sbjct: 957  SIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRF 1016

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
            LS++      ++ +  K+++ E   E  ++  +   E       L +   K      + +
Sbjct: 1017 LSEMLKSLEDLKLKNTKIEVLE---EELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073

Query: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVR-HERSPEVLREIDRLKAQLNELVNSHGRSQEQL 1291
              L  LE L+ Q   ++ K   Q + + + +  E+  +I RL  ++ +        +++ 
Sbjct: 1074 AKLASLEELKRQAE-LDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRF 1132

Query: 1292 IRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE--AERLRQEVREAAQKRRAAED 1349
             + + + D+ ++ R + E + +  + +  EK  + EKE   ERLR  ++E   ++R  E+
Sbjct: 1133 DQQKNDYDQLQKAR-QCEKENLGWQKLESEK-AIKEKEYEIERLRVLLQEEGTRKREYEN 1190

Query: 1350 AVYELQSKRLLLERRKPEEKVVVQE-------VVVTQKDP----KLREEHSRLSGSLDEE 1398
             + +  ++   ++  K +   VVQE       + V ++D     +L +E +R   +L+ E
Sbjct: 1191 ELAKASNR---IQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247

Query: 1399 VGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
               +++LE E QQ++  + + +   S +E+  +K+  ERE         E EK     + 
Sbjct: 1248 TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK-------SEREKNSLRSEI 1300

Query: 1459 KIIMEEVVKLEKD--PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVL-QKAKSQ 1515
            + +  E+ ++E+     LE ST   +  L+ E+++           Q +ID L Q+    
Sbjct: 1301 ERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRY----------QREIDKLRQRPYGS 1350

Query: 1516 EKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWS 1575
             +    E           D    V++ L ++ TA Q  E +   L ++    + L    S
Sbjct: 1351 HRETQTEC------EWTVDTSKLVFDGLRKKVTAMQLYECQ---LIDKTTLDKLLKGKKS 1401

Query: 1576 REE--SELQRARDQADQECGRLQ--QELRALERQKQQQTLQLQEESKLLSQKTESERQKA 1631
             EE  SE+Q     A    G     +E  +L   K+++ +  +    LL  +  +     
Sbjct: 1402 VEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIID 1461

Query: 1632 AQRGQELSRLEAAILRE------KDQIYEKERTLRDLHAKVS------REELSQETQTRE 1679
              R ++L+ +++AI R+      + QIY  E+ +       S       E + +    RE
Sbjct: 1462 PHRNEKLT-VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRE 1520

Query: 1680 TN---LSTKIS---ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCG 1733
            T    L  +I+   +++P     +    A  RG+IDR  Y  L +            P  
Sbjct: 1521 TGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLND------------PRD 1568

Query: 1734 EESVLLDRKSGKQYS-IEAALRCR--------RISKEEYHLYKDG-HLPISEFALLVAGE 1783
             +   +D  + K+ S ++   RCR         +S ++  +   G   P++   L+ +G 
Sbjct: 1569 SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGI 1628

Query: 1784 TKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKT 1843
             +PS+   +  + S         +    F    S         IAGIY+ TT  K  I  
Sbjct: 1629 LRPST---VNELESGQISYDEVGERIKDFLQGSSC--------IAGIYNETTKQKLGIYE 1677

Query: 1844 AVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF 1903
            A+   ++ P T  +LLEAQAATG IVD +S  R  V +A +RGL+     ++LL+A++A 
Sbjct: 1678 AMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAV 1737

Query: 1904 TGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGM 1963
            TG  DP T   +S+ +A+ K  + +   +  L+ Q  TGG+IDPK + R+P+  A   G 
Sbjct: 1738 TGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGY 1797

Query: 1964 ISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
             +EEL+++L D S   K   DP ++E L+Y +   RC KD  +GL LLP
Sbjct: 1798 FNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 1846



 Score =  124 bits (312), Expect = 7e-28
 Identities = 86/341 (25%), Positives = 163/341 (47%), Gaps = 10/341 (2%)

Query: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP-----DAATIRSQ 210
           + Q++ ++    +G  +A +EQ I  H  +   I  Y  QL  +            +  +
Sbjct: 195 MRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEE 254

Query: 211 YRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270
           Y +LLKA+  R   L  L   +Q  +R++  + + +   L  DWSD   + A  ++E   
Sbjct: 255 YENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFS 313

Query: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330
            +  +L  +E+ +N+L+ + +++V  +HPA   I+A+ + L+ +W   L +  C +  L+
Sbjct: 314 IRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLK 373

Query: 331 HVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTER 390
               Y +F EEA S    L  L  ++  KY      P     E +++LE E +++   +R
Sbjct: 374 ENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKR 433

Query: 391 ATGDLQRRSRDVAPLPQRRNP---PQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHA 447
              +L  +S+ +  L + RNP     +P+ + ++CD+   +  + +G+   L DN +   
Sbjct: 434 QVQNLVNKSKKIVQL-KPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSK 492

Query: 448 WVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQAL 488
           W V GPGG     P+    IP P+P AV  + ++    +A+
Sbjct: 493 WYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAI 533



 Score =  102 bits (253), Expect = 5e-21
 Identities = 175/824 (21%), Positives = 340/824 (41%), Gaps = 128/824 (15%)

Query: 1277 LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE 1336
            L E  + H R  E L R  G+   +  E  K    ++    +++ K  VLE+E    R  
Sbjct: 993  LQEAADVHARYIELLTR-SGDYYRFLSEMLK----SLEDLKLKNTKIEVLEEELRLARDA 1047

Query: 1337 VREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK------------L 1384
              E   K +  +  + + Q++    + +    + + ++  +  K  K            L
Sbjct: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107

Query: 1385 REEHSRLSGSLDEEVGRRRQLE-------LEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
             E+ +RL+  +++E  RR+ +E        +  QL+   + ++  L +Q+  S+K   E+
Sbjct: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEK 1167

Query: 1438 ELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNR 1497
            E         E+E+    +QE    E   K E + +L K++  ++    + K Q T++ +
Sbjct: 1168 EY--------EIERLRVLLQE----EGTRKREYENELAKASNRIQ----ESKNQCTQVVQ 1211

Query: 1498 ECKNLQVQIDVLQKAKSQEKTIYKEVIRVQ-----KDRV---LEDERARVWEMLNRERTA 1549
            E ++L V+I VL++ K++ + +  E+ R +     + RV   LE E+ ++   LN+ +T 
Sbjct: 1212 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQ 1271

Query: 1550 RQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGR-LQQELRALERQKQQ 1608
               +EE  R++    +++E    +   E   LQ    + ++ C R L+   R  + Q + 
Sbjct: 1272 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLET 1331

Query: 1609 QTLQLQEESKLLSQK---TESERQKAAQRGQELSRLEAAILREKD---QIYEKE---RTL 1659
            +  + Q E   L Q+   +  E Q   +   + S+L    LR+K    Q+YE +   +T 
Sbjct: 1332 ERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTT 1391

Query: 1660 RD--LHAKVSREELSQETQT----------RETNLSTKISILEPETGKDMSPY------- 1700
             D  L  K S EE++ E Q              +   K S++E +  K +SP        
Sbjct: 1392 LDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLE 1451

Query: 1701 -EAYKRGIID--RGQYLQLQELEC-------DWEEVTTSGPCGEESV--LLDRKSGKQYS 1748
             +A   GIID  R + L +            D +++  +    E+++    D  SGK  S
Sbjct: 1452 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA----EKAITGFDDPFSGKTVS 1507

Query: 1749 IEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQS 1808
            +  A++   I +E         + + E  +   G   P +S+ +   ++ +         
Sbjct: 1508 VSEAIKKNLIDRET-------GMRLLEAQIASGGVVDPVNSVFLPKDVALA--------- 1551

Query: 1809 TSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGI 1868
                       L D         D  T  K S      +  ++P TG  LL  Q  +   
Sbjct: 1552 RGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSF 1611

Query: 1869 VDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF-----------------TGIEDPVT 1911
              +  R+  +V + ++ G++  ++   L + Q ++                  GI +  T
Sbjct: 1612 QGI--RQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETT 1669

Query: 1912 KKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQL 1971
            K++L + EA++ G +   + L  L+ Q  TG ++DP    R+P+++A   G++  E  + 
Sbjct: 1670 KQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEK 1729

Query: 1972 LQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
            L           DP +   +S  +AM +   +   G+ LL A +
Sbjct: 1730 LLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 1773



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 112/588 (19%), Positives = 263/588 (44%), Gaps = 59/588 (10%)

Query: 637  LERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRAL 696
            L + I   + +++ +EA L +E  +  +   ++     L++ + +L  +++ +  +   L
Sbjct: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832

Query: 697  KASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFK 756
            + ++   +     +  +  DL +   +V  LTDR+  +  Q+D R   + D     +Q +
Sbjct: 833  QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR---LWDLEKQIKQLR 889

Query: 757  NCKDNLSS---WLEHLPRSQ-----VRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATAS 808
            N +DN  +   WL    R Q     ++  D  + + + L  QK L  EI  +        
Sbjct: 890  NYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRF-LNEQKNLHSEISGKRDKSEEVQ 948

Query: 809  HLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVA 868
             +++    +++DYELQ  +Y   LE  L +   KR  +      I  +  ++   Y E+ 
Sbjct: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPI-KRTMIQSPSGVILQEAADVHARYIEL- 1006

Query: 869  AAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQ----LEEE 924
                 L +  ++ R + E  +  ED++  +   +  E   +  R++ +        L++ 
Sbjct: 1007 -----LTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061

Query: 925  RKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVE--FYRDPQLEGSLSRVKAQVEEE 982
             ++      + +A+ + L +L+ Q  L+    K+ ++  + +  +L   ++R+  ++E+E
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121

Query: 983  GKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQ-- 1040
             +RR  ++   +       QL+  R+  + +L  +++   +     + +  +LR+ +Q  
Sbjct: 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEE 1181

Query: 1041 -----QLRGEDAVISARLEGLKKEL--LALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQ 1093
                 +   E A  S R++  K +   +  E+  + VK KV+ ++  ++++  + +  A+
Sbjct: 1182 GTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1241

Query: 1094 AL---------RLQMEEDAARR---------KQAEEAVAKLQARIEDLERAISSVEPKV- 1134
            +          RL+ E+   +           + EEA+ K+++  E  ER  +S+  ++ 
Sbjct: 1242 STLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIE 1301

Query: 1135 -IVKEVKKVEQD-PGLLQESSR-LRSLLEEERTKNATLARELSDLHSK 1179
             +  E+K++E+     L++S+R  +S LE ER++     RE+  L  +
Sbjct: 1302 RLQAEIKRIEERCRRKLEDSTRETQSQLETERSR---YQREIDKLRQR 1346



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 32/180 (17%)

Query: 1688 ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQY 1747
            I+ P TG+ +S  +A  +G+ID+    +L+  +  +         G E V    K  K+ 
Sbjct: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAF--------IGFEGV----KGKKKM 2108

Query: 1748 SIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPS--SSLSIGSIISKSPLASPA 1805
            S   A+      KE++  Y+ G   + EF  L  G   P     +S    I K  +   A
Sbjct: 2109 SAAEAV------KEKWLPYEAGQRFL-EFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2161

Query: 1806 PQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAAT 1865
             Q            L D S     +    T  K S K A+ ++M++ ITG +LLEA + +
Sbjct: 2162 AQR-----------LQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2210


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  243 bits (620), Expect = 1e-63
 Identities = 147/378 (38%), Positives = 224/378 (59%), Gaps = 19/378 (5%)

Query: 1655 KERTLRDLHAKVSR---EELSQETQTRETNLSTK--ISILEPETGKDMSPYEAYKRGIID 1709
            KER ++D    +     +E  ++ QT + N   K  + I++PET K+MS  EAYK+G+ID
Sbjct: 2430 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 2489

Query: 1710 RGQYLQLQELECDWEEVTTSGPCGEESVLL-DRKSGKQYSIEAALRCRRISKEEYHLYKD 1768
               + +L E EC+WEE+T +G  G   V+L DRK+G QY I+ A+    + ++ +  Y+ 
Sbjct: 2490 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 2549

Query: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP------------SF 1816
            G L +++FA +++ +    +S S+GS +S    +S   +S S  S             SF
Sbjct: 2550 GSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSF 2609

Query: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876
            S  L ++S PIA I+DT    K SI   + + ++D ITGQ+LLEAQA TGGI+   + ++
Sbjct: 2610 SDTL-EESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2668

Query: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936
             S+  A+ +G+I+     RL  AQKAF G E    KK++S  EAV++ W+P E+    L+
Sbjct: 2669 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2728

Query: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996
             Q+LTGGL+DP+  GRI  ++A+  G I    AQ LQD SSY K LT P +K ++SYK+A
Sbjct: 2729 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDA 2788

Query: 1997 MGRCRKDPLSGLLLLPAA 2014
            + R   + ++GL LL AA
Sbjct: 2789 INRSMVEDITGLRLLEAA 2806



 Score =  233 bits (593), Expect = 2e-60
 Identities = 376/1706 (22%), Positives = 706/1706 (41%), Gaps = 246/1706 (14%)

Query: 480  RLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLG 539
            ++ ++L   K  LAT+++ L+ +     + SQQ P   DL   +  + +TQ+T       
Sbjct: 813  KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPL-YDLDLGKFGEKVTQLTD------ 865

Query: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
                    W R        L DLE +I          Q+       A++  ++ L +   
Sbjct: 866  -------RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS-LESMKF 917

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATL---- 655
            G +   +   LN  KN  S++        E  K A      I+D +  +  + + L    
Sbjct: 918  GDSNTVMRF-LNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL 976

Query: 656  ---VQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAALQNNFQ 711
               ++   I +  G + +  +++  +  ELL +     R L   LK+ E     L+N   
Sbjct: 977  NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL--KLKNTKI 1034

Query: 712  EFCQDLPRQQRQVRALT-----------DRYHAVGDQLDLR----EKVVQDAALTYQQFK 756
            E  ++  R  R   +              +Y A   Q   +    E++ + A L  +  K
Sbjct: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAK 1094

Query: 757  NCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSR-ERDRATASHLSQALQ 815
               D     ++ L     R       + Y+++ +KR  + ++ R ++ +     L +A Q
Sbjct: 1095 QNLDKCYGQIKELNEKITR-------LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ 1147

Query: 816  A--------------ALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLA 861
                           A+++ E + +  R  L+            +A ++     +  NL 
Sbjct: 1148 CEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR 1207

Query: 862  KAY-TEVAAAQ---QQLLQQLEFARKML---------EKKELSEDIRRTHDA-KQGSESP 907
              Y TE+   +   +++  Q E   K L         E ++L ++I R +D+  Q +E  
Sbjct: 1208 NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267

Query: 908  AQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-KEVVEFYRDP 966
             +A   +   KA   E    + + +  LE +  Q++Q R++      +  +E  +  +D 
Sbjct: 1268 RRAEENALQQKACGSE----IMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323

Query: 967  QLEGSLSRVKAQVEEEGKRRAGLQADLEVAA----QKVVQLESKRKTMQPHLLTKEVTQV 1022
              E  + R+KA+ +EE KRR   + +L        ++++ L+++ +T + ++    + Q+
Sbjct: 1324 NKE--IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFET-EINITKTTIHQL 1380

Query: 1023 ERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLA----LEKREVDVKEKVVVKE 1078
                  D+     R QI  L  E+  +S  ++ LK  L      L + E D++++     
Sbjct: 1381 TMQKEEDTSG--YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438

Query: 1079 VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKE 1138
             V   K    V+  Q  +++ EE    ++  ++A   +Q + +++ER    ++ +    +
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET--ND 1496

Query: 1139 VKKVEQDPGLLQ----ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPK----- 1189
             K +E +   LQ    +  +  S   E   K     +EL+ L   Y  V ++R       
Sbjct: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDI 1556

Query: 1190 VQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE 1249
             + Q  + E+     + E+E+ RLK    E + KR  +E+E+E +   L+  +A K T  
Sbjct: 1557 TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-QAIKITNL 1615

Query: 1250 YKEVTQEVVRHERSPEVLREI-DRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV 1308
             +++ Q  +  +RS + LR+  D L   L E      R+QE+L RL  E +  RR+  + 
Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLRE----KQRTQEELRRLSSEVEALRRQLLQ- 1670

Query: 1309 ETKTVSKEVVRHEK-DPVLEKEAERLRQ-----EVREAAQKRRAAEDAVYELQSKRLLLE 1362
            E ++V +  +R+E     +E ++  L +     E  ++  +    E  + E + + L LE
Sbjct: 1671 EQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLE 1730

Query: 1363 ----RRKPEEKVVVQEVVVTQKDPKLREEHSR---LSGSLDEEVGRRRQLELEVQQLRAG 1415
                RR   E    +   + +   +L+  ++R   L G +++    R  L  E+++ +  
Sbjct: 1731 YDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQ 1790

Query: 1416 VEEQEGLLSFQEDRSKKLAVERE--------LRQLTLRIQELEKRPPTVQEKIIMEEVVK 1467
              E    +   +++  ++  ERE        L Q   R+Q LE      +  +  E  VK
Sbjct: 1791 ALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK 1850

Query: 1468 LEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQ 1527
                  LE   + ++ DL+Q KTQ +      + ++ +    +K++ ++ ++  E+ R+Q
Sbjct: 1851 QR----LECEKQQIQNDLNQWKTQYSRKEEAIRKIESE---REKSEREKNSLRSEIERLQ 1903

Query: 1528 KD---------RVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREE 1578
             +         R LED        L  ER+  Q   ++ R+      R       W+ + 
Sbjct: 1904 AEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDT 1963

Query: 1579 SELQ----------------------------RARDQADQECGRLQQELR-------ALE 1603
            S+L                             + +   ++    +Q  LR       A  
Sbjct: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASA 2023

Query: 1604 RQKQQQTLQLQEESKLLSQKTES---ERQKAA------QRGQELSRLEAAILRE------ 1648
              K++ +L   +  KL+S ++     E Q A        R ++L+ +++AI R+      
Sbjct: 2024 SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT-VDSAIARDLIDFDD 2082

Query: 1649 KDQIYEKERTLRDLHAKVS------REELSQETQTRETN---LSTKIS---ILEPETGKD 1696
            + QIY  E+ +       S       E + +    RET    L  +I+   +++P     
Sbjct: 2083 RQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVF 2142

Query: 1697 MSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYS-IEAALRC 1755
            +    A  RG+IDR  Y  L +            P   +   +D  + K+ S ++   RC
Sbjct: 2143 LPKDVALARGLIDRDLYRSLND------------PRDSQKNFVDPVTKKKVSYVQLKERC 2190

Query: 1756 R--------RISKEEYHLYKDG-HLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
            R         +S ++  +   G   P++   L+ +G  +PS+   +  + S         
Sbjct: 2191 RIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPST---VNELESGQISYDEVG 2247

Query: 1807 QSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATG 1866
            +    F    S         IAGIY+ TT  K  I  A+   ++ P T  +LLEAQAATG
Sbjct: 2248 ERIKDFLQGSSC--------IAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 2299

Query: 1867 GIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWM 1926
             IVD +S  R  V +A +RGL+     ++LL+A++A TG  DP T   +S+ +A+ K  +
Sbjct: 2300 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 2359

Query: 1927 PRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPI 1986
             +   +  L+ Q  TGG+IDPK + R+P+  A   G  +EEL+++L D S   K   DP 
Sbjct: 2360 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 2419

Query: 1987 SKERLSYKEAMGRCRKDPLSGLLLLP 2012
            ++E L+Y +   RC KD  +GL LLP
Sbjct: 2420 TEENLTYLQLKERCIKDEETGLCLLP 2445



 Score =  230 bits (587), Expect = 9e-60
 Identities = 324/1534 (21%), Positives = 650/1534 (42%), Gaps = 264/1534 (17%)

Query: 637  LERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRAL 696
            L + I   + +++ +EA L +E  +  +   ++     L++ + +L  +++ +  +   L
Sbjct: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832

Query: 697  KASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFK 756
            + ++   +     +  +  DL +   +V  LTDR+  +  Q+D R   + D     +Q +
Sbjct: 833  QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR---LWDLEKQIKQLR 889

Query: 757  NCKDNLSS---WLEHLPRSQ-----VRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATAS 808
            N +DN  +   WL    R Q     ++  D  + + + L  QK L  EI  +        
Sbjct: 890  NYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRF-LNEQKNLHSEISGKRDKSEEVQ 948

Query: 809  HLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP----LQES--IQAQEKNLAK 862
             +++    +++DYELQ  +Y   LE  L +   +    +P    LQE+  + A+   L  
Sbjct: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008

Query: 863  AYTEVAAAQQQLLQQLEFARKMLEKKE-LSEDIRRTHDA--------------------- 900
               +      ++L+ LE  +    K E L E++R   DA                     
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAE 1068

Query: 901  --------------KQGSESPAQAGRES---------------EALKAQLEEERKRVARV 931
                          K+ +E   ++ +++                 L  ++E+E++R   V
Sbjct: 1069 CSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV 1128

Query: 932  QHELEAQRSQLLQLRTQRPLER-------LEEKEVVEFYRDPQLEGSLSRVKAQVEEEGK 984
            +   + Q++   QL+  R  E+       LE ++ ++     + E  + R++  ++EEG 
Sbjct: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK-----EKEYEIERLRVLLQEEGT 1183

Query: 985  RRAGLQADL-EVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLR 1043
            R+   + +L +V      ++ + R   +  +   + T  E     +  +  LR Q+ +L 
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243

Query: 1044 GEDAVISARLEGLKKELL-ALEKR----EVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQ 1098
             E+  +   +  L   +L A E+R    E  +++K    E+++ +++LE ++  Q ++ +
Sbjct: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLE-IELKQVMQQR 1302

Query: 1099 MEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKV-----IVKEVKKVEQDPGLLQESS 1153
             E++A  ++  EEA   +Q + +++ER  +  + +         E+ KV  +    +E  
Sbjct: 1303 SEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD--EEII 1360

Query: 1154 RLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRL 1213
             L++  E E     T   +L+        ++K+      + ++  + + +    +EI RL
Sbjct: 1361 SLKNQFETEINITKTTIHQLT--------MQKEEDTSGYRAQIDNLTRENRSLSEEIKRL 1412

Query: 1214 KAKLQEMAGKRSGVEKEVE--KLLPDLEVLRAQKPTVEYKEVTQ----EVVRHERS---- 1263
            K  L +       VE++++  K        R Q+  VE ++VTQ    E VR+++S    
Sbjct: 1413 KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDA 1472

Query: 1264 ----PEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVR 1319
                 +  +EI+RLK  +++  N     +++  RLQ  + + ++  +   T+T++K  V+
Sbjct: 1473 AKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSA-TETINKLKVQ 1531

Query: 1320 HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQS--KRLLLERRKPEEKVVVQEVVV 1377
                   E+E  RLR +    +Q+R   +  +   Q+  K L L+++K EE++   +   
Sbjct: 1532 -------EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTA 1584

Query: 1378 TQ---KDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQED-----R 1429
            ++   K  KL EE   +  SL E+  +   L  +++Q     +  E  L  Q D      
Sbjct: 1585 SEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHL 1644

Query: 1430 SKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEK 1489
             +K   + ELR+L+  ++ L ++    QE +    +    ++   +K+ E     L++ K
Sbjct: 1645 REKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL----RNEHFQKAIEDKSRSLNESK 1700

Query: 1490 TQVTELN--------------RECKNLQVQIDVLQKAKSQ-----EKTIY--KEVIRVQK 1528
             ++  L                E +NL+++ D L++ +S+       TI   +  +++  
Sbjct: 1701 IEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 1760

Query: 1529 DRVLE-----DERARVWEMLNRE--RTARQARE------EEARRLRERIDRAETLG---R 1572
            +R LE     ++  R  E L +E  +  +QA E      E   +  + +   E+L    +
Sbjct: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820

Query: 1573 TWSREESELQRARDQADQECGRLQQELRA---LERQKQQQTLQL---------QEES--K 1618
               ++++ LQR  D+ ++    L+ E R    LE +KQQ    L         +EE+  K
Sbjct: 1821 VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1880

Query: 1619 LLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTR 1678
            + S++ +SER+K + R  E+ RL+A I R +++                R +L   T+  
Sbjct: 1881 IESEREKSEREKNSLRS-EIERLQAEIKRIEERC---------------RRKLEDSTRET 1924

Query: 1679 ETNLSTKISILEPETGK-DMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESV 1737
            ++ L T+ S  + E  K    PY +++             + EC+W   T        S 
Sbjct: 1925 QSQLETERSRYQREIDKLRQRPYGSHRE-----------TQTECEWTVDT--------SK 1965

Query: 1738 LLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIIS 1797
            L+     K+ +      C+ I K        G   + E A  +    + + S++  S   
Sbjct: 1966 LVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 2025

Query: 1798 KSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQK 1857
            K   +    +     SP  ++ L +      GI D   + K ++ +A+A++++D    Q+
Sbjct: 2026 KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQ 2085

Query: 1858 LLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSV 1917
            +  A+ A  G  D  S +  SV +A+++ LI+  +  RLL AQ A  G+ DPV       
Sbjct: 2086 IYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPV------- 2138

Query: 1918 GEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESS 1977
                        SV                     +P   AL  G+I  +L + L D   
Sbjct: 2139 -----------NSVF--------------------LPKDVALARGLIDRDLYRSLNDPRD 2167

Query: 1978 YEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLL 2011
             +K+  DP++K+++SY +   RCR +P +GLLLL
Sbjct: 2168 SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLL 2201



 Score =  124 bits (312), Expect = 7e-28
 Identities = 86/341 (25%), Positives = 163/341 (47%), Gaps = 10/341 (2%)

Query: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP-----DAATIRSQ 210
           + Q++ ++    +G  +A +EQ I  H  +   I  Y  QL  +            +  +
Sbjct: 195 MRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEE 254

Query: 211 YRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270
           Y +LLKA+  R   L  L   +Q  +R++  + + +   L  DWSD   + A  ++E   
Sbjct: 255 YENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFS 313

Query: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330
            +  +L  +E+ +N+L+ + +++V  +HPA   I+A+ + L+ +W   L +  C +  L+
Sbjct: 314 IRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLK 373

Query: 331 HVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTER 390
               Y +F EEA S    L  L  ++  KY      P     E +++LE E +++   +R
Sbjct: 374 ENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKR 433

Query: 391 ATGDLQRRSRDVAPLPQRRNP---PQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHA 447
              +L  +S+ +  L + RNP     +P+ + ++CD+   +  + +G+   L DN +   
Sbjct: 434 QVQNLVNKSKKIVQL-KPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSK 492

Query: 448 WVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQAL 488
           W V GPGG     P+    IP P+P AV  + ++    +A+
Sbjct: 493 WYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAI 533



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 234/1277 (18%), Positives = 459/1277 (35%), Gaps = 283/1277 (22%)

Query: 37   QELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKD 96
            +E++ L ++ +   +  +  I E   + + D  N      L       R LK+  V L D
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ--LDRLSRENRDLKDEIVRLND 1258

Query: 97   LFLDVDKARRLKHPQA--------------EEIEKDIKQLHERVTQECAEYRALYEKMVL 142
              L   + RR     A              + +E ++KQ+ ++ +++ A ++   E+   
Sbjct: 1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA-- 1316

Query: 143  PPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP 202
                      A+ ++ K K++          E +++    N L K  + Y +++ SL   
Sbjct: 1317 ----------AKTIQDKNKEI-ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ 1365

Query: 203  DAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPA 262
                I      + +    + +        +   TR+  +L+E+ +R+     + L     
Sbjct: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLK----NTLTQTTE 1421

Query: 263  GVRREYEHFKQHELLSQE--QSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLN 320
             +RR  E  +Q +    E  Q   QLE      VELR                       
Sbjct: 1422 NLRRVEEDIQQQKATGSEVSQRKQQLE------VELR----------------------- 1452

Query: 321  LCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEA 380
                Q TQ++  E+  R+++  D  ++T+   N  ++              T   + LE 
Sbjct: 1453 ----QVTQMR-TEESVRYKQSLDDAAKTIQDKNKEIERLKQLID-----KETNDRKCLED 1502

Query: 381  EEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLV 440
            E  RL   +R   DLQ+ +        +    +Q L    I      + + +  ER    
Sbjct: 1503 ENARL---QRVQYDLQKANSSATETINKLKVQEQELTRLRI------DYERVSQER---- 1549

Query: 441  DNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATVQSRLK 500
                                          D D + R      ELQ  KQK+    +RLK
Sbjct: 1550 ---------------------------TVKDQD-ITRFQNSLKELQLQKQKVEEELNRLK 1581

Query: 501  ASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPLE 560
             +A E    S +     +      + L  Q  ++     Q+E+  +   R+        +
Sbjct: 1582 RTASED---SCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638

Query: 561  DLEGRIHSHEGTAQRLQSLGTEKETAQKEC--------EAFLSTRPVGPAALQLPVALNS 612
             L+G +   + T + L+ L +E E  +++         +A L       A      +LN 
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
             K    +++ L SL     K  L LE ++++                        L+   
Sbjct: 1699 SK---IEIERLQSLTENLTKEHLMLEEELRN------------------------LRLEY 1731

Query: 673  SELQRQRREL-LEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRY 731
             +L+R R E   ++   +L L   L+ S +    LQ        DL R++  +R   +++
Sbjct: 1732 DDLRRGRSEADSDKNATILELRSQLQISNNRTLELQG----LINDLQRERENLRQEIEKF 1787

Query: 732  HAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQK 791
                      +K   +A+   Q+ KN                        Q    +Q ++
Sbjct: 1788 ----------QKQALEASNRIQESKN------------------------QCTQVVQERE 1813

Query: 792  RLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQE 851
             L  +I+  E+D+A    L   L  A     L+A+T                 RV    E
Sbjct: 1814 SLLVKIKVLEQDKARLQRLEDELNRAKS--TLEAET-----------------RVKQRLE 1854

Query: 852  SIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM--LEKKELSEDIRRTHDAKQGSESPAQ 909
              + Q +N    +    + +++ ++++E  R+    EK  L  +I R           A+
Sbjct: 1855 CEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ---------AE 1905

Query: 910  AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLE 969
              R  E  + +LE+  +     Q +LE +RS     R QR +++L ++     +R+ Q E
Sbjct: 1906 IKRIEERCRRKLEDSTR---ETQSQLETERS-----RYQREIDKLRQRPYGS-HRETQTE 1956

Query: 970  GSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLD 1029
               +   +++  +G R+       +V A ++ + +   KT    LL K    VE      
Sbjct: 1957 CEWTVDTSKLVFDGLRK-------KVTAMQLYECQLIDKTTLDKLL-KGKKSVE------ 2002

Query: 1030 SQAAQLRIQIQQ-LRGEDAVISAR---------LEGLKKELLALEKREVDVKEKVVVKEV 1079
                ++  +IQ  LRG  ++  A          +E  +K+L++ E   + ++ +     +
Sbjct: 2003 ----EVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058

Query: 1080 VKVEKNLEM-VKAAQALRLQMEEDAARRKQAEEAVA---------------KLQARIEDL 1123
            +   +N ++ V +A A  L   +D  +   AE+A+                 ++  + D 
Sbjct: 2059 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 2118

Query: 1124 ERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVV 1183
            E  +  +E ++    V        L ++ +  R L++ +  ++    R+ S  +    V 
Sbjct: 2119 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRD-SQKNFVDPVT 2177

Query: 1184 EKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGV---EKEVEKLLPDLEV 1240
            +K+   VQL+ER     +++P T   +  ++ +     G R  V   E     +L    V
Sbjct: 2178 KKKVSYVQLKERC----RIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTV 2233

Query: 1241 LRAQKPTVEYKEVTQEV 1257
               +   + Y EV + +
Sbjct: 2234 NELESGQISYDEVGERI 2250



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 32/180 (17%)

Query: 1688 ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQY 1747
            I+ P TG+ +S  +A  +G+ID+    +L+  +  +         G E V    K  K+ 
Sbjct: 2660 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAF--------IGFEGV----KGKKKM 2707

Query: 1748 SIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPS--SSLSIGSIISKSPLASPA 1805
            S   A+      KE++  Y+ G   + EF  L  G   P     +S    I K  +   A
Sbjct: 2708 SAAEAV------KEKWLPYEAGQRFL-EFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2760

Query: 1806 PQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAAT 1865
             Q            L D S     +    T  K S K A+ ++M++ ITG +LLEA + +
Sbjct: 2761 AQR-----------LQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2809


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  211 bits (537), Expect = 6e-54
 Identities = 263/1302 (20%), Positives = 538/1302 (41%), Gaps = 157/1302 (12%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 644  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 703

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 704  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 763

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 764  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 822

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 823  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 882

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 883  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 942

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 943  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1002

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 1003 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1062

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 1063 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1122

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 1123 LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1181

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 1182 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1241

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 1242 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1301

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 1302 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1361

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1362 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1420

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELS-EDIRRTH--------- 898
              + I  +  +L   YT +     Q ++    + K LE++E S E+ ++ H         
Sbjct: 1421 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1480

Query: 899  ----------DAKQGSESPAQAGR-ESEALKAQLEEERKRVARVQHEL--------EAQR 939
                      DA++  + P    +  SE +  + E+  + +  +Q  L        + +R
Sbjct: 1481 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1540

Query: 940  SQL-LQLRTQRPLERLEEKEVVEFYRDPQLEGSL---SRVKAQVEEEGKRRAGLQADLEV 995
            ++L  Q++T +    L   E ++  ++ Q  G +    ++ A+ ++E K +  LQ   ++
Sbjct: 1541 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEK--LQGICDL 1598

Query: 996  AAQKVVQLESKRKTMQ-----PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVIS 1050
              Q   +L   ++          L   +  Q E    +   A  L   ++          
Sbjct: 1599 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1658

Query: 1051 ARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE 1110
             +L    K L+  +  E  +K + +  +  + +K L+ V    A++ + E+ AA  KQ E
Sbjct: 1659 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV-VTTAIKEETEKVAA-VKQLE 1716

Query: 1111 EAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLA 1170
            E+  K++  ++ L       E +   K  + +EQ+    QE     ++ EE+      L 
Sbjct: 1717 ESKTKIENLLDWLSNVDKDSE-RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE 1775

Query: 1171 REL--------SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
             ++         +L+ +Y  V+ Q  K+  Q   H+   +  ++ Q        L E  G
Sbjct: 1776 TDVDGQVGTTQENLNQQYQKVKAQHEKIISQ---HQAVIIATQSAQ-------VLLEKQG 1825

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVN 1282
            +    E E EKL  +++ L+    T   +   +  + H     +  E+++  A   E  +
Sbjct: 1826 QYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEH 1880

Query: 1283 SHGRSQEQLIRLQGERDEWRRERAKVE-TKTVSKEVVRHEKD 1323
               +S+++L  L+   D+      K++  K+ S++V+ H+ D
Sbjct: 1881 WLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1922



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 261/1457 (17%), Positives = 557/1457 (38%), Gaps = 198/1457 (13%)

Query: 336  RRFQEEADSVSQTLAKLNSNLDA-KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGD 394
            ++ QEE+ ++ Q L K+N      + +PAP       T++ +Q ++ E  L        +
Sbjct: 2459 QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQV-EQNKSFEAELKQNVNKVQE 2517

Query: 395  LQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSG--EVQLLQGERYKLVDNTDPHAWVVQG 452
            L+ +  ++  L +  + P+ P     + + DS   E+  L  +R + ++ +  +    Q 
Sbjct: 2518 LKDKLTEL--LEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2575

Query: 453  PGGETKR---APAACFCIPAP---DPDAVARASRLASELQALKQKLATVQ---SRLKASA 503
               + K+          +  P   DP+ +   +    ++Q L Q+ AT +    +L A+ 
Sbjct: 2576 VEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQILLQEFATRKPQYEQLTAAG 2632

Query: 504  VESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ----IERQVLA---WARAPLSRP 556
               L    + PS   +   Q   +  +   L G L      I++ ++    +     S  
Sbjct: 2633 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2692

Query: 557  TPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE-----------------CEAFLSTRPV 599
              L DL+ ++ S    +    ++  + ETAQK                  CE   +    
Sbjct: 2693 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE 2752

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEA 659
                 +L   L  +   F DV+     + +  ++A     Q Q   R  + +  T  +E 
Sbjct: 2753 EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQ 2812

Query: 660  ----PIPAEPGALQERVSELQRQRRELLEQ-----QTCVLRLHRALKASEHACAALQNNF 710
                PI A+   L+  + + +   + L  Q     +T     +  LK      AALQ   
Sbjct: 2813 NKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQL 2872

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
                 +     +QV+   +R + + + L+   K  +     +     C++NL        
Sbjct: 2873 NTIKTNWDTFNKQVK---ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-----I 2924

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            +  + P++G + IA     QK + Q     E    TA+ L   L     D E+  D  + 
Sbjct: 2925 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL---LSVCEIDKEVVTDENKS 2981

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQE---KNLAKAYTEVAAAQQQLLQQLEFARKMLEK 887
             ++           +V  + E + +++   +N+ + + E     ++  +QL+ A++ L+ 
Sbjct: 2982 LIQ-----------KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3029

Query: 888  KELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRT 947
                      HD+  GS++       S      L+ ++K +  ++H+++  +        
Sbjct: 3030 ---------IHDS-LGSQA------YSNKYLTMLQTQQKSLQALKHQVDLAK-------- 3065

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKR 1007
                 RL +  VVE           S V  QVE   +  + L   ++   +K   LE+K 
Sbjct: 3066 -----RLAQDLVVE----ASDSKGTSDVLLQVETIAQEHSTLSQQVD---EKCSFLETKL 3113

Query: 1008 KTMQ--PHLLTKEVTQ-VERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALE 1064
            + +    + + +  +Q  E D  LDS A   R   + L+ +   I A L+ L+  + + +
Sbjct: 3114 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-DAETLQKQKETIKAFLKKLEALMASND 3172

Query: 1065 KREVDVKEKVVVKE----VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
                  K  +  +E    +V ++++LE                A  KQ  + + + QAR 
Sbjct: 3173 NANKTCKMMLATEETSPDLVGIKRDLE----------------ALSKQCNKLLDRAQARE 3216

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
            E +E  I            K++E+    L+E S L    EE       +  E   ++   
Sbjct: 3217 EQVEGTI------------KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ-- 3262

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK------L 1234
                        Q  + ++FQ     ++EI  L+ K Q++     G+ +   K      L
Sbjct: 3263 ------------QLNMFKVFQ-----KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
              DL+ + A+  T+  K+V Q   R  +  E L    R +  L  L++    ++E +   
Sbjct: 3306 EHDLDDVNARWKTLN-KKVAQ---RAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3361

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKD--PVLEKEAERLRQEVREAAQKRRAAEDAVY 1352
            +    E++  +A+++ + + + ++   K    V+++E E++     E A K +  +    
Sbjct: 3362 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI-ATTAEPADKVKILKQLSL 3420

Query: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL 1412
                   LL + +   + +    VV Q+  +  E  +    ++++ +     +  +  +L
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3480

Query: 1413 RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472
               + + + L     + +K L     + Q +L++    +    VQ K+   +V  +E   
Sbjct: 3481 EEQIAQHKALEDDIINHNKHLHQAVSIGQ-SLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539

Query: 1473 DLEKSTEALRWDLDQEK---TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE--VIRVQ 1527
                 +E L+  L   K       EL      +  ++  L       + ++K+   +RV 
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599

Query: 1528 KDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQ 1587
            ++ +L  ++     +LN     +Q   +E   ++++++  +   +  ++  +++ +  +Q
Sbjct: 3600 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3659

Query: 1588 ADQECGRLQQELRALERQKQQQTLQ-LQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646
            A Q   RL      L     +  ++ L  E+++L  +  S+ Q   +  ++ ++   A+L
Sbjct: 3660 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3719

Query: 1647 REKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
               +++      L    A+   E++  E   R   +S  I+             E     
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT----------QKVEEIDAA 3769

Query: 1707 IIDRGQYLQLQELECDW 1723
            I+   Q+ Q  + E  W
Sbjct: 3770 ILRSQQFDQAADAELSW 3786



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 157/867 (18%), Positives = 343/867 (39%), Gaps = 98/867 (11%)

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QR++   TDR+ ++  + ++    ++D    YQ +++    L + L+             
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ------------- 2004

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
               A +  A K L++ I    ++       ++ALQ  +   ++  +     L+ T  V  
Sbjct: 2005 ---ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE----KLKKTAEVLL 2057

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLE--FARKMLEKKELSEDIRRTH 898
              R  + P +  IQ    ++   Y +++ +  +  ++L+    R +  +  L E +    
Sbjct: 2058 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG 2117

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-K 957
            + +   +   Q    S AL+  + +       ++ ++  ++S +  +      E++++  
Sbjct: 2118 NVESSLKEQGQVPLNSTALQDIISKN----IMLEQDIAGRQSSINAMN-----EKVKKFM 2168

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E  +      L+  +  + A+  E   +     A +E    KV   E+  + +Q  L TK
Sbjct: 2169 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2228

Query: 1018 EVTQVERD-PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                 E D PG D    +L   +Q+   E       LE L   L  +    +   + +V+
Sbjct: 2229 TQALTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVL 2286

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAK-LQARIEDLERAISSVEPKVI 1135
            ++   + K  + ++     + +       +  A + + K L++ I++  + +  V+P   
Sbjct: 2287 EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2346

Query: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNA------------TLARELSDLHSKYSVV 1183
             +++ K  +D   LQE   L++  E ++  N+            T A+ ++ + S  +V+
Sbjct: 2347 AEDLGKSLEDTKKLQEKWSLKT-PEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2405

Query: 1184 EKQRPKVQLQE---------RVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
              +      +E            ++  +    E     LK K+ E+  K S ++K  E+ 
Sbjct: 2406 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEES 2465

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
               ++ L+    T    + T      E     + +    +A+L + VN     +++L  L
Sbjct: 2466 SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL 2525

Query: 1295 QGERDE------WRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAE 1348
              E  +      W++   ++++K                   + L Q   +  QK   + 
Sbjct: 2526 LEENPDTPEAPRWKQMLTEIDSKW------------------QELNQLTIDRQQKLEESS 2567

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK-LREEHSRLSGSLDEEVGRRRQLEL 1407
            + + + Q+    L++   E++++V  +     DP  L  +  ++   L E   R+ Q E 
Sbjct: 2568 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE- 2626

Query: 1408 EVQQLRAGVEEQEGLLSFQ-EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKI--IMEE 1464
              Q   AG    +G+LS   ED S +  V+ +L  +T   Q+ +     + ++   I + 
Sbjct: 2627 --QLTAAG----QGILSRPGEDPSLRGIVKEQLAAVT---QKWDSLTGQLSDRCDWIDQA 2677

Query: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
            +VK  +   L +S      DLD + +    ++     +  Q++  QK K QE    K+ I
Sbjct: 2678 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK-QEIQQEKKQI 2736

Query: 1525 RVQKDRVLEDERARVWEMLNRERTARQ 1551
            +V +  + ED  A V E   +   +RQ
Sbjct: 2737 KVAQ-ALCEDLSALVKEEYLKAELSRQ 2762



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 222/1120 (19%), Positives = 441/1120 (39%), Gaps = 191/1120 (17%)

Query: 495  VQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLS 554
            VQS+L  S V  +   +++ S S+L        L Q        G+ E +++ W      
Sbjct: 3523 VQSKLDFSQVWYIEIQEKSHSRSEL--------LQQALCNAKIFGEDEVELMNWLNEVHD 3574

Query: 555  RPTPLEDLEGRIHSHEGTAQRLQSLGTEKETA----QKECEAFLS-----TRPVGPAALQ 605
            +   L  L  + +S EG  ++   L   +E      Q   +A L+      +  G   L 
Sbjct: 3575 K---LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3631

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
            +   L ++K ++ D+  L +   +  + AL L R++      +  +    V+   +  E 
Sbjct: 3632 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTW-LDKVEVELLSYET 3690

Query: 666  GALQ-ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQV 724
              L+ E  S+ Q + +EL ++      L  +L  +E + A L+       + L   ++ V
Sbjct: 3691 QVLKGEEASQAQMRPKELKKEAKNNKALLDSL--NEVSSALLELVPWRAREGL---EKMV 3745

Query: 725  RALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD---GPS 781
                +RY  V D +  + + +  A L  QQF    D   SW+    +  +   D      
Sbjct: 3746 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3805

Query: 782  QIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAP 841
            Q + +LQ QK  T EI                    L+  ++  D  +   +   A S  
Sbjct: 3806 QTSAQLQVQKTFTMEI--------------------LRHKDIIDDLVKSGHKIMTACSEE 3845

Query: 842  KRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK-----KELSEDIRR 896
            ++       +S++ +   + K Y  +     +   QLE A+ ++ +     +EL   +  
Sbjct: 3846 EK-------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3898

Query: 897  THDAKQGSESPAQAGRESEALKAQLEEERK-RVARVQH-----ELEAQRSQLLQLRTQRP 950
            T        +PA    E E L+ Q EE R+ R    +H     ++     QLL+L     
Sbjct: 3899 TQSIISQLPAPA---LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3955

Query: 951  LERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTM 1010
               ++EK V           +   + +Q++E+ K+RA     L+ A  +  Q   K   +
Sbjct: 3956 FS-IQEKYV-----------AADTLYSQIKEDVKKRA---VALDEAISQSTQFHDKIDQI 4000

Query: 1011 QPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDV 1070
                L + V ++ + P + ++  +++ QI     E+  +S  +E L+     L++R  ++
Sbjct: 4001 L-ESLERIVERLRQPPSISAEVEKIKEQI----SENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 1071 ------KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
                   +K +  + V+ +K  +MV   + +   +EE  A+     E   K     + + 
Sbjct: 4056 IARSGGTDKDISAKAVQ-DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC--DHMS 4112

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVE 1184
              ++  + +  ++++    +DPG+        S++++++    T+  E+  L  +  +V 
Sbjct: 4113 LIVTIKDTQDFIRDL----EDPGIDP------SVVKQQQEAAETIREEIDGLQEELDIV- 4161

Query: 1185 KQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
                 + L     E+     E ++ I  +K  + E+      + K  +  +  LE   A 
Sbjct: 4162 -----INLGS---ELIAACGEPDKPI--VKKSIDELNSAWDSLNKAWKDRIDKLE--EAM 4209

Query: 1245 KPTVEYKEVTQEVV--------RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            +  V+Y++  Q V         +      +  +++ +K Q+ EL      + +Q I +  
Sbjct: 4210 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEM-- 4267

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHE-KDPVLEKE------AERL--RQEVREAA-----Q 1342
               E    +A++  K V++E  +H  +DP++E +       ER+  RQ   E A     Q
Sbjct: 4268 ---ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4324

Query: 1343 KRRAAEDAVYELQSKRLLLERRKP-------------EEKVVVQEVVVTQK--------- 1380
             + A ++ +  L     LL  +KP             +  V+  +V+  Q          
Sbjct: 4325 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4384

Query: 1381 ----DPKLREEHSRLSGSLDEEVGRRRQLELE-----VQQLRAGVEEQEGLLSFQEDRSK 1431
                +    EE S L   L E + +R Q  LE      QQL   + + +G     ED  +
Sbjct: 4385 NDLIESSAGEEASNLQNKL-EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQ 4443

Query: 1432 KLA-VERELRQLTLRIQELEKRPPTVQEK--IIMEEVVKLEKDPDLEKS--TEALRWDLD 1486
             L   ER L    L  + L   P T +E+  + ME     E   +  KS   +  +    
Sbjct: 4444 WLTDTERHL----LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4499

Query: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
              K+  T ++++  NL+ + + ++   ++ KT  +E + +
Sbjct: 4500 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNL 4539



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 158/889 (17%), Positives = 337/889 (37%), Gaps = 133/889 (14%)

Query: 845  RVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKK------ELSEDIRRTH 898
            +V   QE++  Q + +   + ++ +  Q ++   + A+ +LEK+      E  E +++  
Sbjct: 1781 QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNM 1840

Query: 899  DAKQGSESPAQAGRESE-----ALKAQLEEERKRVARVQH----------ELEAQRSQLL 943
               +     A A  E +     +L+ +LE+        +H           LEA    + 
Sbjct: 1841 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1900

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQ-LEGSLSRVKAQVEEEGKRRAG----------LQAD 992
             L T+   ++   ++V+    D + +  S +RV    +   KR  G          +Q  
Sbjct: 1901 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1960

Query: 993  LEVAAQKVVQLESKRKTMQPHLLTK-EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
            L+ A  +   L SK   +  +L    +  Q   D      A     +    +     I+ 
Sbjct: 1961 LDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAV 2020

Query: 1052 RLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEE 1111
              + L+++L   +  +  +  + V  E  K++K  E++  A+   L  + D       ++
Sbjct: 2021 DPKNLQRQLEETKALQGQISSQQVAVE--KLKKTAEVLLDARGSLLPAKNDI------QK 2072

Query: 1112 AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL-------------LQESSRL--- 1155
             +  +  R EDL ++++    K+ +   + +    GL             L+E  ++   
Sbjct: 2073 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 2132

Query: 1156 RSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ----------LQERVHEIFQVDPE 1205
             + L++  +KN  L ++++   S  + + ++  K            LQ ++ ++     E
Sbjct: 2133 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 2192

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE------------YKEV 1253
               +     AK++E+  K    E   EKL   LE        V+             +E 
Sbjct: 2193 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 2252

Query: 1254 TQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            T E + H++  EVL  +      L E ++SHG   ++ + L+   +  ++ +   +T   
Sbjct: 2253 TSEFLEHKKHLEVLHSL------LKE-ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2305

Query: 1314 SKEVVR--HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVV 1371
             KE V    E+    +   + L+  ++E  +K    + +       + L + +K +EK  
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2365

Query: 1372 VQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE--------LEVQQLRAGVEE---QE 1420
            ++    T +  K+      L   +       + +         L  +      EE    +
Sbjct: 2366 LK----TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK 2421

Query: 1421 GLLSFQEDRSK--------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK-- 1470
            GL S ++D +          L ++ ++ +L  ++ +L+K     +   +M+ + K+ K  
Sbjct: 2422 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE--ESSAMMQWLQKMNKTA 2479

Query: 1471 ----DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                       TEA++  ++Q K+   EL +    +Q   D L +   +      +    
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN----PDTPEA 2535

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586
             + + +  E    W+ LN+    RQ + EE+     +    E   + W  E+  +     
Sbjct: 2536 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV-- 2593

Query: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRG 1635
                  G L  +   L  Q+QQ  + LQE     ++K + E+  AA +G
Sbjct: 2594 -----LGPLSIDPNMLNTQRQQVQILLQE---FATRKPQYEQLTAAGQG 2634



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 115/557 (20%), Positives = 229/557 (41%), Gaps = 102/557 (18%)

Query: 1209 EITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEV 1266
            EI R++A    +A  ++ +  E +++L +L     Q    ++ E +QE  V       ++
Sbjct: 1014 EIDRIRAS--NVASIKTMLPGEHQQVLSNL-----QSRFEDFLEDSQESQVFSGSDITQL 1066

Query: 1267 LREIDRLKAQLNELVNSHGRSQEQ--------------LIRLQGERDEWRRE-RAKVETK 1311
             +E++  K    EL+ S  R +++               +RL+   D   R+ R  +E  
Sbjct: 1067 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD 1126

Query: 1312 TVSKEVVRHEKDPVLEKEAERLRQEVREAAQK------RRAAEDAVYELQSK-------- 1357
             + + V R  +   L+KE ERL+ ++     K      + AA  +V  L+S+        
Sbjct: 1127 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 1186

Query: 1358 -------RLLLERRKPEEKVV----VQEVVVTQKDPKLREEHSRLSGSLD---------- 1396
                      +++ K    V+      E +V   + KL EE + ++   +          
Sbjct: 1187 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1246

Query: 1397 --EEVGRRRQ----LELEVQQLRAGVEE-----QEGLLSFQEDRSK-KLAVERELR---Q 1441
               EV  +RQ    LE E+Q+ +A  +E     +E  L F   + K    VER      Q
Sbjct: 1247 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1306

Query: 1442 LTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQ 1491
            +  R+++LE    +++          + I   E  + +   +  ++++ L   L+Q+K  
Sbjct: 1307 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1366

Query: 1492 VTELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTAR 1550
            V+E+  +    Q ++D  QK A+    T+    ++    R + D + +      R +++ 
Sbjct: 1367 VSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1422

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
                +E   LR R     TL   + +           A     RL++E ++LE +K++  
Sbjct: 1423 DLIIQEFMDLRTRYTALVTLMTQYIK----------FAGDSLKRLEEEEKSLEEEKKEHV 1472

Query: 1611 LQLQEESKLLS--QKTESERQKAAQRGQELSRLEA-AILREKDQIYEKERTLRDLHAKVS 1667
             + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  +T++   AK  
Sbjct: 1473 EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1532

Query: 1668 REELSQETQTRETNLST 1684
             +   +E    E  + T
Sbjct: 1533 DKMTDEERNELEKQVKT 1549



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 69/374 (18%), Positives = 143/374 (38%), Gaps = 52/374 (13%)

Query: 471  DPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
            +  A   AS L ++L+ L Q+   V           L  ++Q     D A  QA+    +
Sbjct: 4389 ESSAGEEASNLQNKLEVLNQRWQNV-----------LEKTEQRKQQLDGALRQAKGFHGE 4437

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTP--LEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            +  L   L   ER +LA      S+P     E  + +++ H       ++     ++  +
Sbjct: 4438 IEDLQQWLTDTERHLLA------SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4491

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
            + +  L+  P   A   +   +N++K K+  V+   +    K + AL+L  +  ++ +  
Sbjct: 4492 KGQQMLARCPKS-AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4550

Query: 649  RGFEATLVQEAPIPAEPGALQERV-----------SELQRQRRELLEQQTCVLRLHRALK 697
              +     Q   + + P  + + V           +E+   R +++E            K
Sbjct: 4551 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD----------K 4600

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
               H     Q       QD+   +  + ++  R+  V  +L  R + + DA    +QF  
Sbjct: 4601 TGTHLKYFSQK------QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654

Query: 758  CKDNLSSWLEHLPR---SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQAL 814
                L  WLE   +   S++  ++ P +I  +L   K   + + ++     T +   ++L
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714

Query: 815  --QAALQDYELQAD 826
              + +L D  L+ D
Sbjct: 4715 KEKTSLADDNLKLD 4728



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 17/175 (9%)

Query: 38   ELALLISRMQANADQVE--RDILETQKRLQQ---------DRLNSEQSQALQHQQETGRS 86
            E   +IS++ A A + E  R   E  ++L++         D++N    Q L+     G S
Sbjct: 3898 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3957

Query: 87   LKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDV 146
            ++E  V    L+  + +  + +    +E      Q H+++ Q       + E++  PP +
Sbjct: 3958 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4017

Query: 147  GPRVDWAR--VLEQKQKQVCAGQYGPGMAEL----EQQIAEHNILQKEIDAYGQQ 195
               V+  +  + E K   V   +  P    L    E+ IA      K+I A   Q
Sbjct: 4018 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 415 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 474

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 475 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 515


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  211 bits (537), Expect = 6e-54
 Identities = 263/1302 (20%), Positives = 538/1302 (41%), Gaps = 157/1302 (12%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 655  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 714

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 715  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 774

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 775  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 833

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 834  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 893

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 894  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 953

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 954  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1013

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 1014 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1073

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 1074 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1133

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 1134 LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1192

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 1193 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1252

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 1253 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1312

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 1313 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1372

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1373 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1431

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELS-EDIRRTH--------- 898
              + I  +  +L   YT +     Q ++    + K LE++E S E+ ++ H         
Sbjct: 1432 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1491

Query: 899  ----------DAKQGSESPAQAGR-ESEALKAQLEEERKRVARVQHEL--------EAQR 939
                      DA++  + P    +  SE +  + E+  + +  +Q  L        + +R
Sbjct: 1492 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1551

Query: 940  SQL-LQLRTQRPLERLEEKEVVEFYRDPQLEGSL---SRVKAQVEEEGKRRAGLQADLEV 995
            ++L  Q++T +    L   E ++  ++ Q  G +    ++ A+ ++E K +  LQ   ++
Sbjct: 1552 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEK--LQGICDL 1609

Query: 996  AAQKVVQLESKRKTMQ-----PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVIS 1050
              Q   +L   ++          L   +  Q E    +   A  L   ++          
Sbjct: 1610 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1669

Query: 1051 ARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE 1110
             +L    K L+  +  E  +K + +  +  + +K L+ V    A++ + E+ AA  KQ E
Sbjct: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV-VTTAIKEETEKVAA-VKQLE 1727

Query: 1111 EAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLA 1170
            E+  K++  ++ L       E +   K  + +EQ+    QE     ++ EE+      L 
Sbjct: 1728 ESKTKIENLLDWLSNVDKDSE-RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE 1786

Query: 1171 REL--------SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
             ++         +L+ +Y  V+ Q  K+  Q   H+   +  ++ Q        L E  G
Sbjct: 1787 TDVDGQVGTTQENLNQQYQKVKAQHEKIISQ---HQAVIIATQSAQ-------VLLEKQG 1836

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVN 1282
            +    E E EKL  +++ L+    T   +   +  + H     +  E+++  A   E  +
Sbjct: 1837 QYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEH 1891

Query: 1283 SHGRSQEQLIRLQGERDEWRRERAKVE-TKTVSKEVVRHEKD 1323
               +S+++L  L+   D+      K++  K+ S++V+ H+ D
Sbjct: 1892 WLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1933



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 261/1457 (17%), Positives = 557/1457 (38%), Gaps = 198/1457 (13%)

Query: 336  RRFQEEADSVSQTLAKLNSNLDA-KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGD 394
            ++ QEE+ ++ Q L K+N      + +PAP       T++ +Q ++ E  L        +
Sbjct: 2470 QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQV-EQNKSFEAELKQNVNKVQE 2528

Query: 395  LQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSG--EVQLLQGERYKLVDNTDPHAWVVQG 452
            L+ +  ++  L +  + P+ P     + + DS   E+  L  +R + ++ +  +    Q 
Sbjct: 2529 LKDKLTEL--LEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2586

Query: 453  PGGETKR---APAACFCIPAP---DPDAVARASRLASELQALKQKLATVQ---SRLKASA 503
               + K+          +  P   DP+ +   +    ++Q L Q+ AT +    +L A+ 
Sbjct: 2587 VEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQILLQEFATRKPQYEQLTAAG 2643

Query: 504  VESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ----IERQVLA---WARAPLSRP 556
               L    + PS   +   Q   +  +   L G L      I++ ++    +     S  
Sbjct: 2644 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2703

Query: 557  TPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE-----------------CEAFLSTRPV 599
              L DL+ ++ S    +    ++  + ETAQK                  CE   +    
Sbjct: 2704 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE 2763

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEA 659
                 +L   L  +   F DV+     + +  ++A     Q Q   R  + +  T  +E 
Sbjct: 2764 EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQ 2823

Query: 660  ----PIPAEPGALQERVSELQRQRRELLEQ-----QTCVLRLHRALKASEHACAALQNNF 710
                PI A+   L+  + + +   + L  Q     +T     +  LK      AALQ   
Sbjct: 2824 NKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQL 2883

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
                 +     +QV+   +R + + + L+   K  +     +     C++NL        
Sbjct: 2884 NTIKTNWDTFNKQVK---ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-----I 2935

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            +  + P++G + IA     QK + Q     E    TA+ L   L     D E+  D  + 
Sbjct: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL---LSVCEIDKEVVTDENKS 2992

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQE---KNLAKAYTEVAAAQQQLLQQLEFARKMLEK 887
             ++           +V  + E + +++   +N+ + + E     ++  +QL+ A++ L+ 
Sbjct: 2993 LIQ-----------KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3040

Query: 888  KELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRT 947
                      HD+  GS++       S      L+ ++K +  ++H+++  +        
Sbjct: 3041 ---------IHDS-LGSQA------YSNKYLTMLQTQQKSLQALKHQVDLAK-------- 3076

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKR 1007
                 RL +  VVE           S V  QVE   +  + L   ++   +K   LE+K 
Sbjct: 3077 -----RLAQDLVVE----ASDSKGTSDVLLQVETIAQEHSTLSQQVD---EKCSFLETKL 3124

Query: 1008 KTMQ--PHLLTKEVTQ-VERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALE 1064
            + +    + + +  +Q  E D  LDS A   R   + L+ +   I A L+ L+  + + +
Sbjct: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-DAETLQKQKETIKAFLKKLEALMASND 3183

Query: 1065 KREVDVKEKVVVKE----VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
                  K  +  +E    +V ++++LE                A  KQ  + + + QAR 
Sbjct: 3184 NANKTCKMMLATEETSPDLVGIKRDLE----------------ALSKQCNKLLDRAQARE 3227

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
            E +E  I            K++E+    L+E S L    EE       +  E   ++   
Sbjct: 3228 EQVEGTI------------KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ-- 3273

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK------L 1234
                        Q  + ++FQ     ++EI  L+ K Q++     G+ +   K      L
Sbjct: 3274 ------------QLNMFKVFQ-----KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
              DL+ + A+  T+  K+V Q   R  +  E L    R +  L  L++    ++E +   
Sbjct: 3317 EHDLDDVNARWKTLN-KKVAQ---RAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3372

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKD--PVLEKEAERLRQEVREAAQKRRAAEDAVY 1352
            +    E++  +A+++ + + + ++   K    V+++E E++     E A K +  +    
Sbjct: 3373 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI-ATTAEPADKVKILKQLSL 3431

Query: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL 1412
                   LL + +   + +    VV Q+  +  E  +    ++++ +     +  +  +L
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3491

Query: 1413 RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472
               + + + L     + +K L     + Q +L++    +    VQ K+   +V  +E   
Sbjct: 3492 EEQIAQHKALEDDIINHNKHLHQAVSIGQ-SLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550

Query: 1473 DLEKSTEALRWDLDQEK---TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE--VIRVQ 1527
                 +E L+  L   K       EL      +  ++  L       + ++K+   +RV 
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610

Query: 1528 KDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQ 1587
            ++ +L  ++     +LN     +Q   +E   ++++++  +   +  ++  +++ +  +Q
Sbjct: 3611 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3670

Query: 1588 ADQECGRLQQELRALERQKQQQTLQ-LQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646
            A Q   RL      L     +  ++ L  E+++L  +  S+ Q   +  ++ ++   A+L
Sbjct: 3671 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730

Query: 1647 REKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
               +++      L    A+   E++  E   R   +S  I+             E     
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT----------QKVEEIDAA 3780

Query: 1707 IIDRGQYLQLQELECDW 1723
            I+   Q+ Q  + E  W
Sbjct: 3781 ILRSQQFDQAADAELSW 3797



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 157/867 (18%), Positives = 343/867 (39%), Gaps = 98/867 (11%)

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QR++   TDR+ ++  + ++    ++D    YQ +++    L + L+             
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ------------- 2015

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
               A +  A K L++ I    ++       ++ALQ  +   ++  +     L+ T  V  
Sbjct: 2016 ---ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE----KLKKTAEVLL 2068

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLE--FARKMLEKKELSEDIRRTH 898
              R  + P +  IQ    ++   Y +++ +  +  ++L+    R +  +  L E +    
Sbjct: 2069 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG 2128

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-K 957
            + +   +   Q    S AL+  + +       ++ ++  ++S +  +      E++++  
Sbjct: 2129 NVESSLKEQGQVPLNSTALQDIISKN----IMLEQDIAGRQSSINAMN-----EKVKKFM 2179

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E  +      L+  +  + A+  E   +     A +E    KV   E+  + +Q  L TK
Sbjct: 2180 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2239

Query: 1018 EVTQVERD-PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                 E D PG D    +L   +Q+   E       LE L   L  +    +   + +V+
Sbjct: 2240 TQALTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVL 2297

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAK-LQARIEDLERAISSVEPKVI 1135
            ++   + K  + ++     + +       +  A + + K L++ I++  + +  V+P   
Sbjct: 2298 EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2357

Query: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNA------------TLARELSDLHSKYSVV 1183
             +++ K  +D   LQE   L++  E ++  N+            T A+ ++ + S  +V+
Sbjct: 2358 AEDLGKSLEDTKKLQEKWSLKT-PEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2416

Query: 1184 EKQRPKVQLQE---------RVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
              +      +E            ++  +    E     LK K+ E+  K S ++K  E+ 
Sbjct: 2417 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEES 2476

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
               ++ L+    T    + T      E     + +    +A+L + VN     +++L  L
Sbjct: 2477 SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL 2536

Query: 1295 QGERDE------WRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAE 1348
              E  +      W++   ++++K                   + L Q   +  QK   + 
Sbjct: 2537 LEENPDTPEAPRWKQMLTEIDSKW------------------QELNQLTIDRQQKLEESS 2578

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK-LREEHSRLSGSLDEEVGRRRQLEL 1407
            + + + Q+    L++   E++++V  +     DP  L  +  ++   L E   R+ Q E 
Sbjct: 2579 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE- 2637

Query: 1408 EVQQLRAGVEEQEGLLSFQ-EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKI--IMEE 1464
              Q   AG    +G+LS   ED S +  V+ +L  +T   Q+ +     + ++   I + 
Sbjct: 2638 --QLTAAG----QGILSRPGEDPSLRGIVKEQLAAVT---QKWDSLTGQLSDRCDWIDQA 2688

Query: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
            +VK  +   L +S      DLD + +    ++     +  Q++  QK K QE    K+ I
Sbjct: 2689 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK-QEIQQEKKQI 2747

Query: 1525 RVQKDRVLEDERARVWEMLNRERTARQ 1551
            +V +  + ED  A V E   +   +RQ
Sbjct: 2748 KVAQ-ALCEDLSALVKEEYLKAELSRQ 2773



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 222/1120 (19%), Positives = 441/1120 (39%), Gaps = 191/1120 (17%)

Query: 495  VQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLS 554
            VQS+L  S V  +   +++ S S+L        L Q        G+ E +++ W      
Sbjct: 3534 VQSKLDFSQVWYIEIQEKSHSRSEL--------LQQALCNAKIFGEDEVELMNWLNEVHD 3585

Query: 555  RPTPLEDLEGRIHSHEGTAQRLQSLGTEKETA----QKECEAFLS-----TRPVGPAALQ 605
            +   L  L  + +S EG  ++   L   +E      Q   +A L+      +  G   L 
Sbjct: 3586 K---LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3642

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
            +   L ++K ++ D+  L +   +  + AL L R++      +  +    V+   +  E 
Sbjct: 3643 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTW-LDKVEVELLSYET 3701

Query: 666  GALQ-ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQV 724
              L+ E  S+ Q + +EL ++      L  +L  +E + A L+       + L   ++ V
Sbjct: 3702 QVLKGEEASQAQMRPKELKKEAKNNKALLDSL--NEVSSALLELVPWRAREGL---EKMV 3756

Query: 725  RALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD---GPS 781
                +RY  V D +  + + +  A L  QQF    D   SW+    +  +   D      
Sbjct: 3757 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3816

Query: 782  QIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAP 841
            Q + +LQ QK  T EI                    L+  ++  D  +   +   A S  
Sbjct: 3817 QTSAQLQVQKTFTMEI--------------------LRHKDIIDDLVKSGHKIMTACSEE 3856

Query: 842  KRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK-----KELSEDIRR 896
            ++       +S++ +   + K Y  +     +   QLE A+ ++ +     +EL   +  
Sbjct: 3857 EK-------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3909

Query: 897  THDAKQGSESPAQAGRESEALKAQLEEERK-RVARVQH-----ELEAQRSQLLQLRTQRP 950
            T        +PA    E E L+ Q EE R+ R    +H     ++     QLL+L     
Sbjct: 3910 TQSIISQLPAPA---LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966

Query: 951  LERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTM 1010
               ++EK V           +   + +Q++E+ K+RA     L+ A  +  Q   K   +
Sbjct: 3967 FS-IQEKYV-----------AADTLYSQIKEDVKKRA---VALDEAISQSTQFHDKIDQI 4011

Query: 1011 QPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDV 1070
                L + V ++ + P + ++  +++ QI     E+  +S  +E L+     L++R  ++
Sbjct: 4012 L-ESLERIVERLRQPPSISAEVEKIKEQI----SENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 1071 ------KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
                   +K +  + V+ +K  +MV   + +   +EE  A+     E   K     + + 
Sbjct: 4067 IARSGGTDKDISAKAVQ-DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC--DHMS 4123

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVE 1184
              ++  + +  ++++    +DPG+        S++++++    T+  E+  L  +  +V 
Sbjct: 4124 LIVTIKDTQDFIRDL----EDPGIDP------SVVKQQQEAAETIREEIDGLQEELDIV- 4172

Query: 1185 KQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
                 + L     E+     E ++ I  +K  + E+      + K  +  +  LE   A 
Sbjct: 4173 -----INLGS---ELIAACGEPDKPI--VKKSIDELNSAWDSLNKAWKDRIDKLE--EAM 4220

Query: 1245 KPTVEYKEVTQEVV--------RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            +  V+Y++  Q V         +      +  +++ +K Q+ EL      + +Q I +  
Sbjct: 4221 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEM-- 4278

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHE-KDPVLEKE------AERL--RQEVREAA-----Q 1342
               E    +A++  K V++E  +H  +DP++E +       ER+  RQ   E A     Q
Sbjct: 4279 ---ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335

Query: 1343 KRRAAEDAVYELQSKRLLLERRKP-------------EEKVVVQEVVVTQK--------- 1380
             + A ++ +  L     LL  +KP             +  V+  +V+  Q          
Sbjct: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4395

Query: 1381 ----DPKLREEHSRLSGSLDEEVGRRRQLELE-----VQQLRAGVEEQEGLLSFQEDRSK 1431
                +    EE S L   L E + +R Q  LE      QQL   + + +G     ED  +
Sbjct: 4396 NDLIESSAGEEASNLQNKL-EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQ 4454

Query: 1432 KLA-VERELRQLTLRIQELEKRPPTVQEK--IIMEEVVKLEKDPDLEKS--TEALRWDLD 1486
             L   ER L    L  + L   P T +E+  + ME     E   +  KS   +  +    
Sbjct: 4455 WLTDTERHL----LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4510

Query: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
              K+  T ++++  NL+ + + ++   ++ KT  +E + +
Sbjct: 4511 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNL 4550



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 158/889 (17%), Positives = 337/889 (37%), Gaps = 133/889 (14%)

Query: 845  RVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKK------ELSEDIRRTH 898
            +V   QE++  Q + +   + ++ +  Q ++   + A+ +LEK+      E  E +++  
Sbjct: 1792 QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNM 1851

Query: 899  DAKQGSESPAQAGRESE-----ALKAQLEEERKRVARVQH----------ELEAQRSQLL 943
               +     A A  E +     +L+ +LE+        +H           LEA    + 
Sbjct: 1852 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1911

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQ-LEGSLSRVKAQVEEEGKRRAG----------LQAD 992
             L T+   ++   ++V+    D + +  S +RV    +   KR  G          +Q  
Sbjct: 1912 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1971

Query: 993  LEVAAQKVVQLESKRKTMQPHLLTK-EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
            L+ A  +   L SK   +  +L    +  Q   D      A     +    +     I+ 
Sbjct: 1972 LDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAV 2031

Query: 1052 RLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEE 1111
              + L+++L   +  +  +  + V  E  K++K  E++  A+   L  + D       ++
Sbjct: 2032 DPKNLQRQLEETKALQGQISSQQVAVE--KLKKTAEVLLDARGSLLPAKNDI------QK 2083

Query: 1112 AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL-------------LQESSRL--- 1155
             +  +  R EDL ++++    K+ +   + +    GL             L+E  ++   
Sbjct: 2084 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 2143

Query: 1156 RSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ----------LQERVHEIFQVDPE 1205
             + L++  +KN  L ++++   S  + + ++  K            LQ ++ ++     E
Sbjct: 2144 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 2203

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE------------YKEV 1253
               +     AK++E+  K    E   EKL   LE        V+             +E 
Sbjct: 2204 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 2263

Query: 1254 TQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            T E + H++  EVL  +      L E ++SHG   ++ + L+   +  ++ +   +T   
Sbjct: 2264 TSEFLEHKKHLEVLHSL------LKE-ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316

Query: 1314 SKEVVR--HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVV 1371
             KE V    E+    +   + L+  ++E  +K    + +       + L + +K +EK  
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2376

Query: 1372 VQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE--------LEVQQLRAGVEE---QE 1420
            ++    T +  K+      L   +       + +         L  +      EE    +
Sbjct: 2377 LK----TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK 2432

Query: 1421 GLLSFQEDRSK--------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK-- 1470
            GL S ++D +          L ++ ++ +L  ++ +L+K     +   +M+ + K+ K  
Sbjct: 2433 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE--ESSAMMQWLQKMNKTA 2490

Query: 1471 ----DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                       TEA++  ++Q K+   EL +    +Q   D L +   +      +    
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN----PDTPEA 2546

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586
             + + +  E    W+ LN+    RQ + EE+     +    E   + W  E+  +     
Sbjct: 2547 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV-- 2604

Query: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRG 1635
                  G L  +   L  Q+QQ  + LQE     ++K + E+  AA +G
Sbjct: 2605 -----LGPLSIDPNMLNTQRQQVQILLQE---FATRKPQYEQLTAAGQG 2645



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 115/557 (20%), Positives = 229/557 (41%), Gaps = 102/557 (18%)

Query: 1209 EITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEV 1266
            EI R++A    +A  ++ +  E +++L +L     Q    ++ E +QE  V       ++
Sbjct: 1025 EIDRIRAS--NVASIKTMLPGEHQQVLSNL-----QSRFEDFLEDSQESQVFSGSDITQL 1077

Query: 1267 LREIDRLKAQLNELVNSHGRSQEQ--------------LIRLQGERDEWRRE-RAKVETK 1311
             +E++  K    EL+ S  R +++               +RL+   D   R+ R  +E  
Sbjct: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD 1137

Query: 1312 TVSKEVVRHEKDPVLEKEAERLRQEVREAAQK------RRAAEDAVYELQSK-------- 1357
             + + V R  +   L+KE ERL+ ++     K      + AA  +V  L+S+        
Sbjct: 1138 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 1197

Query: 1358 -------RLLLERRKPEEKVV----VQEVVVTQKDPKLREEHSRLSGSLD---------- 1396
                      +++ K    V+      E +V   + KL EE + ++   +          
Sbjct: 1198 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1257

Query: 1397 --EEVGRRRQ----LELEVQQLRAGVEE-----QEGLLSFQEDRSK-KLAVERELR---Q 1441
               EV  +RQ    LE E+Q+ +A  +E     +E  L F   + K    VER      Q
Sbjct: 1258 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1317

Query: 1442 LTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQ 1491
            +  R+++LE    +++          + I   E  + +   +  ++++ L   L+Q+K  
Sbjct: 1318 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1377

Query: 1492 VTELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTAR 1550
            V+E+  +    Q ++D  QK A+    T+    ++    R + D + +      R +++ 
Sbjct: 1378 VSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1433

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
                +E   LR R     TL   + +           A     RL++E ++LE +K++  
Sbjct: 1434 DLIIQEFMDLRTRYTALVTLMTQYIK----------FAGDSLKRLEEEEKSLEEEKKEHV 1483

Query: 1611 LQLQEESKLLS--QKTESERQKAAQRGQELSRLEA-AILREKDQIYEKERTLRDLHAKVS 1667
             + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  +T++   AK  
Sbjct: 1484 EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1543

Query: 1668 REELSQETQTRETNLST 1684
             +   +E    E  + T
Sbjct: 1544 DKMTDEERNELEKQVKT 1560



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 69/374 (18%), Positives = 143/374 (38%), Gaps = 52/374 (13%)

Query: 471  DPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
            +  A   AS L ++L+ L Q+   V           L  ++Q     D A  QA+    +
Sbjct: 4400 ESSAGEEASNLQNKLEVLNQRWQNV-----------LEKTEQRKQQLDGALRQAKGFHGE 4448

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTP--LEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            +  L   L   ER +LA      S+P     E  + +++ H       ++     ++  +
Sbjct: 4449 IEDLQQWLTDTERHLLA------SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4502

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
            + +  L+  P   A   +   +N++K K+  V+   +    K + AL+L  +  ++ +  
Sbjct: 4503 KGQQMLARCPKS-AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561

Query: 649  RGFEATLVQEAPIPAEPGALQERV-----------SELQRQRRELLEQQTCVLRLHRALK 697
              +     Q   + + P  + + V           +E+   R +++E            K
Sbjct: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD----------K 4611

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
               H     Q       QD+   +  + ++  R+  V  +L  R + + DA    +QF  
Sbjct: 4612 TGTHLKYFSQK------QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665

Query: 758  CKDNLSSWLEHLPR---SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQAL 814
                L  WLE   +   S++  ++ P +I  +L   K   + + ++     T +   ++L
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725

Query: 815  --QAALQDYELQAD 826
              + +L D  L+ D
Sbjct: 4726 KEKTSLADDNLKLD 4739



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 17/175 (9%)

Query: 38   ELALLISRMQANADQVE--RDILETQKRLQQ---------DRLNSEQSQALQHQQETGRS 86
            E   +IS++ A A + E  R   E  ++L++         D++N    Q L+     G S
Sbjct: 3909 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3968

Query: 87   LKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDV 146
            ++E  V    L+  + +  + +    +E      Q H+++ Q       + E++  PP +
Sbjct: 3969 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4028

Query: 147  GPRVDWAR--VLEQKQKQVCAGQYGPGMAEL----EQQIAEHNILQKEIDAYGQQ 195
               V+  +  + E K   V   +  P    L    E+ IA      K+I A   Q
Sbjct: 4029 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 426 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 485

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 486 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 526


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  211 bits (537), Expect = 6e-54
 Identities = 263/1302 (20%), Positives = 538/1302 (41%), Gaps = 157/1302 (12%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 793  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 852

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 853  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 912

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 913  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 971

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 972  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 1031

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 1032 KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 1091

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 1092 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1151

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 1152 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1211

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 1212 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1271

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 1272 LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1330

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 1331 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1390

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 1391 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1450

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 1451 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1510

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1511 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1569

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELS-EDIRRTH--------- 898
              + I  +  +L   YT +     Q ++    + K LE++E S E+ ++ H         
Sbjct: 1570 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1629

Query: 899  ----------DAKQGSESPAQAGR-ESEALKAQLEEERKRVARVQHEL--------EAQR 939
                      DA++  + P    +  SE +  + E+  + +  +Q  L        + +R
Sbjct: 1630 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1689

Query: 940  SQL-LQLRTQRPLERLEEKEVVEFYRDPQLEGSL---SRVKAQVEEEGKRRAGLQADLEV 995
            ++L  Q++T +    L   E ++  ++ Q  G +    ++ A+ ++E K +  LQ   ++
Sbjct: 1690 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEK--LQGICDL 1747

Query: 996  AAQKVVQLESKRKTMQ-----PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVIS 1050
              Q   +L   ++          L   +  Q E    +   A  L   ++          
Sbjct: 1748 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1807

Query: 1051 ARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE 1110
             +L    K L+  +  E  +K + +  +  + +K L+ V    A++ + E+ AA  KQ E
Sbjct: 1808 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV-VTTAIKEETEKVAA-VKQLE 1865

Query: 1111 EAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLA 1170
            E+  K++  ++ L       E +   K  + +EQ+    QE     ++ EE+      L 
Sbjct: 1866 ESKTKIENLLDWLSNVDKDSE-RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE 1924

Query: 1171 REL--------SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
             ++         +L+ +Y  V+ Q  K+  Q   H+   +  ++ Q        L E  G
Sbjct: 1925 TDVDGQVGTTQENLNQQYQKVKAQHEKIISQ---HQAVIIATQSAQ-------VLLEKQG 1974

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVN 1282
            +    E E EKL  +++ L+    T   +   +  + H     +  E+++  A   E  +
Sbjct: 1975 QYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEH 2029

Query: 1283 SHGRSQEQLIRLQGERDEWRRERAKVE-TKTVSKEVVRHEKD 1323
               +S+++L  L+   D+      K++  K+ S++V+ H+ D
Sbjct: 2030 WLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 2071



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 261/1457 (17%), Positives = 557/1457 (38%), Gaps = 198/1457 (13%)

Query: 336  RRFQEEADSVSQTLAKLNSNLDA-KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGD 394
            ++ QEE+ ++ Q L K+N      + +PAP       T++ +Q ++ E  L        +
Sbjct: 2608 QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQV-EQNKSFEAELKQNVNKVQE 2666

Query: 395  LQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSG--EVQLLQGERYKLVDNTDPHAWVVQG 452
            L+ +  ++  L +  + P+ P     + + DS   E+  L  +R + ++ +  +    Q 
Sbjct: 2667 LKDKLTEL--LEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2724

Query: 453  PGGETKR---APAACFCIPAP---DPDAVARASRLASELQALKQKLATVQ---SRLKASA 503
               + K+          +  P   DP+ +   +    ++Q L Q+ AT +    +L A+ 
Sbjct: 2725 VEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQILLQEFATRKPQYEQLTAAG 2781

Query: 504  VESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ----IERQVLA---WARAPLSRP 556
               L    + PS   +   Q   +  +   L G L      I++ ++    +     S  
Sbjct: 2782 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2841

Query: 557  TPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE-----------------CEAFLSTRPV 599
              L DL+ ++ S    +    ++  + ETAQK                  CE   +    
Sbjct: 2842 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE 2901

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEA 659
                 +L   L  +   F DV+     + +  ++A     Q Q   R  + +  T  +E 
Sbjct: 2902 EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQ 2961

Query: 660  ----PIPAEPGALQERVSELQRQRRELLEQ-----QTCVLRLHRALKASEHACAALQNNF 710
                PI A+   L+  + + +   + L  Q     +T     +  LK      AALQ   
Sbjct: 2962 NKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQL 3021

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
                 +     +QV+   +R + + + L+   K  +     +     C++NL        
Sbjct: 3022 NTIKTNWDTFNKQVK---ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-----I 3073

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            +  + P++G + IA     QK + Q     E    TA+ L   L     D E+  D  + 
Sbjct: 3074 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL---LSVCEIDKEVVTDENKS 3130

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQE---KNLAKAYTEVAAAQQQLLQQLEFARKMLEK 887
             ++           +V  + E + +++   +N+ + + E     ++  +QL+ A++ L+ 
Sbjct: 3131 LIQ-----------KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3178

Query: 888  KELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRT 947
                      HD+  GS++       S      L+ ++K +  ++H+++  +        
Sbjct: 3179 ---------IHDS-LGSQA------YSNKYLTMLQTQQKSLQALKHQVDLAK-------- 3214

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKR 1007
                 RL +  VVE           S V  QVE   +  + L   ++   +K   LE+K 
Sbjct: 3215 -----RLAQDLVVE----ASDSKGTSDVLLQVETIAQEHSTLSQQVD---EKCSFLETKL 3262

Query: 1008 KTMQ--PHLLTKEVTQ-VERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALE 1064
            + +    + + +  +Q  E D  LDS A   R   + L+ +   I A L+ L+  + + +
Sbjct: 3263 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-DAETLQKQKETIKAFLKKLEALMASND 3321

Query: 1065 KREVDVKEKVVVKE----VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
                  K  +  +E    +V ++++LE                A  KQ  + + + QAR 
Sbjct: 3322 NANKTCKMMLATEETSPDLVGIKRDLE----------------ALSKQCNKLLDRAQARE 3365

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
            E +E  I            K++E+    L+E S L    EE       +  E   ++   
Sbjct: 3366 EQVEGTI------------KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ-- 3411

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK------L 1234
                        Q  + ++FQ     ++EI  L+ K Q++     G+ +   K      L
Sbjct: 3412 ------------QLNMFKVFQ-----KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
              DL+ + A+  T+  K+V Q   R  +  E L    R +  L  L++    ++E +   
Sbjct: 3455 EHDLDDVNARWKTLN-KKVAQ---RAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3510

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKD--PVLEKEAERLRQEVREAAQKRRAAEDAVY 1352
            +    E++  +A+++ + + + ++   K    V+++E E++     E A K +  +    
Sbjct: 3511 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI-ATTAEPADKVKILKQLSL 3569

Query: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL 1412
                   LL + +   + +    VV Q+  +  E  +    ++++ +     +  +  +L
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3629

Query: 1413 RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472
               + + + L     + +K L     + Q +L++    +    VQ K+   +V  +E   
Sbjct: 3630 EEQIAQHKALEDDIINHNKHLHQAVSIGQ-SLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688

Query: 1473 DLEKSTEALRWDLDQEK---TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE--VIRVQ 1527
                 +E L+  L   K       EL      +  ++  L       + ++K+   +RV 
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748

Query: 1528 KDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQ 1587
            ++ +L  ++     +LN     +Q   +E   ++++++  +   +  ++  +++ +  +Q
Sbjct: 3749 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3808

Query: 1588 ADQECGRLQQELRALERQKQQQTLQ-LQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646
            A Q   RL      L     +  ++ L  E+++L  +  S+ Q   +  ++ ++   A+L
Sbjct: 3809 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3868

Query: 1647 REKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
               +++      L    A+   E++  E   R   +S  I+             E     
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT----------QKVEEIDAA 3918

Query: 1707 IIDRGQYLQLQELECDW 1723
            I+   Q+ Q  + E  W
Sbjct: 3919 ILRSQQFDQAADAELSW 3935



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 157/867 (18%), Positives = 343/867 (39%), Gaps = 98/867 (11%)

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QR++   TDR+ ++  + ++    ++D    YQ +++    L + L+             
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ------------- 2153

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
               A +  A K L++ I    ++       ++ALQ  +   ++  +     L+ T  V  
Sbjct: 2154 ---ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE----KLKKTAEVLL 2206

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLE--FARKMLEKKELSEDIRRTH 898
              R  + P +  IQ    ++   Y +++ +  +  ++L+    R +  +  L E +    
Sbjct: 2207 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG 2266

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-K 957
            + +   +   Q    S AL+  + +       ++ ++  ++S +  +      E++++  
Sbjct: 2267 NVESSLKEQGQVPLNSTALQDIISKN----IMLEQDIAGRQSSINAMN-----EKVKKFM 2317

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E  +      L+  +  + A+  E   +     A +E    KV   E+  + +Q  L TK
Sbjct: 2318 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2377

Query: 1018 EVTQVERD-PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                 E D PG D    +L   +Q+   E       LE L   L  +    +   + +V+
Sbjct: 2378 TQALTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVL 2435

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAK-LQARIEDLERAISSVEPKVI 1135
            ++   + K  + ++     + +       +  A + + K L++ I++  + +  V+P   
Sbjct: 2436 EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2495

Query: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNA------------TLARELSDLHSKYSVV 1183
             +++ K  +D   LQE   L++  E ++  N+            T A+ ++ + S  +V+
Sbjct: 2496 AEDLGKSLEDTKKLQEKWSLKT-PEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2554

Query: 1184 EKQRPKVQLQE---------RVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
              +      +E            ++  +    E     LK K+ E+  K S ++K  E+ 
Sbjct: 2555 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEES 2614

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
               ++ L+    T    + T      E     + +    +A+L + VN     +++L  L
Sbjct: 2615 SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL 2674

Query: 1295 QGERDE------WRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAE 1348
              E  +      W++   ++++K                   + L Q   +  QK   + 
Sbjct: 2675 LEENPDTPEAPRWKQMLTEIDSKW------------------QELNQLTIDRQQKLEESS 2716

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK-LREEHSRLSGSLDEEVGRRRQLEL 1407
            + + + Q+    L++   E++++V  +     DP  L  +  ++   L E   R+ Q E 
Sbjct: 2717 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE- 2775

Query: 1408 EVQQLRAGVEEQEGLLSFQ-EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKI--IMEE 1464
              Q   AG    +G+LS   ED S +  V+ +L  +T   Q+ +     + ++   I + 
Sbjct: 2776 --QLTAAG----QGILSRPGEDPSLRGIVKEQLAAVT---QKWDSLTGQLSDRCDWIDQA 2826

Query: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
            +VK  +   L +S      DLD + +    ++     +  Q++  QK K QE    K+ I
Sbjct: 2827 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK-QEIQQEKKQI 2885

Query: 1525 RVQKDRVLEDERARVWEMLNRERTARQ 1551
            +V +  + ED  A V E   +   +RQ
Sbjct: 2886 KVAQ-ALCEDLSALVKEEYLKAELSRQ 2911



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 222/1120 (19%), Positives = 441/1120 (39%), Gaps = 191/1120 (17%)

Query: 495  VQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLS 554
            VQS+L  S V  +   +++ S S+L        L Q        G+ E +++ W      
Sbjct: 3672 VQSKLDFSQVWYIEIQEKSHSRSEL--------LQQALCNAKIFGEDEVELMNWLNEVHD 3723

Query: 555  RPTPLEDLEGRIHSHEGTAQRLQSLGTEKETA----QKECEAFLS-----TRPVGPAALQ 605
            +   L  L  + +S EG  ++   L   +E      Q   +A L+      +  G   L 
Sbjct: 3724 K---LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3780

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
            +   L ++K ++ D+  L +   +  + AL L R++      +  +    V+   +  E 
Sbjct: 3781 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTW-LDKVEVELLSYET 3839

Query: 666  GALQ-ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQV 724
              L+ E  S+ Q + +EL ++      L  +L  +E + A L+       + L   ++ V
Sbjct: 3840 QVLKGEEASQAQMRPKELKKEAKNNKALLDSL--NEVSSALLELVPWRAREGL---EKMV 3894

Query: 725  RALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD---GPS 781
                +RY  V D +  + + +  A L  QQF    D   SW+    +  +   D      
Sbjct: 3895 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3954

Query: 782  QIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAP 841
            Q + +LQ QK  T EI                    L+  ++  D  +   +   A S  
Sbjct: 3955 QTSAQLQVQKTFTMEI--------------------LRHKDIIDDLVKSGHKIMTACSEE 3994

Query: 842  KRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK-----KELSEDIRR 896
            ++       +S++ +   + K Y  +     +   QLE A+ ++ +     +EL   +  
Sbjct: 3995 EK-------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 4047

Query: 897  THDAKQGSESPAQAGRESEALKAQLEEERK-RVARVQH-----ELEAQRSQLLQLRTQRP 950
            T        +PA    E E L+ Q EE R+ R    +H     ++     QLL+L     
Sbjct: 4048 TQSIISQLPAPA---LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 4104

Query: 951  LERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTM 1010
               ++EK V           +   + +Q++E+ K+RA     L+ A  +  Q   K   +
Sbjct: 4105 FS-IQEKYV-----------AADTLYSQIKEDVKKRA---VALDEAISQSTQFHDKIDQI 4149

Query: 1011 QPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDV 1070
                L + V ++ + P + ++  +++ QI     E+  +S  +E L+     L++R  ++
Sbjct: 4150 L-ESLERIVERLRQPPSISAEVEKIKEQI----SENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 1071 ------KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
                   +K +  + V+ +K  +MV   + +   +EE  A+     E   K     + + 
Sbjct: 4205 IARSGGTDKDISAKAVQ-DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC--DHMS 4261

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVE 1184
              ++  + +  ++++    +DPG+        S++++++    T+  E+  L  +  +V 
Sbjct: 4262 LIVTIKDTQDFIRDL----EDPGIDP------SVVKQQQEAAETIREEIDGLQEELDIV- 4310

Query: 1185 KQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
                 + L     E+     E ++ I  +K  + E+      + K  +  +  LE   A 
Sbjct: 4311 -----INLGS---ELIAACGEPDKPI--VKKSIDELNSAWDSLNKAWKDRIDKLE--EAM 4358

Query: 1245 KPTVEYKEVTQEVV--------RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            +  V+Y++  Q V         +      +  +++ +K Q+ EL      + +Q I +  
Sbjct: 4359 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEM-- 4416

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHE-KDPVLEKE------AERL--RQEVREAA-----Q 1342
               E    +A++  K V++E  +H  +DP++E +       ER+  RQ   E A     Q
Sbjct: 4417 ---ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4473

Query: 1343 KRRAAEDAVYELQSKRLLLERRKP-------------EEKVVVQEVVVTQK--------- 1380
             + A ++ +  L     LL  +KP             +  V+  +V+  Q          
Sbjct: 4474 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4533

Query: 1381 ----DPKLREEHSRLSGSLDEEVGRRRQLELE-----VQQLRAGVEEQEGLLSFQEDRSK 1431
                +    EE S L   L E + +R Q  LE      QQL   + + +G     ED  +
Sbjct: 4534 NDLIESSAGEEASNLQNKL-EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQ 4592

Query: 1432 KLA-VERELRQLTLRIQELEKRPPTVQEK--IIMEEVVKLEKDPDLEKS--TEALRWDLD 1486
             L   ER L    L  + L   P T +E+  + ME     E   +  KS   +  +    
Sbjct: 4593 WLTDTERHL----LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4648

Query: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
              K+  T ++++  NL+ + + ++   ++ KT  +E + +
Sbjct: 4649 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNL 4688



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 158/889 (17%), Positives = 337/889 (37%), Gaps = 133/889 (14%)

Query: 845  RVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKK------ELSEDIRRTH 898
            +V   QE++  Q + +   + ++ +  Q ++   + A+ +LEK+      E  E +++  
Sbjct: 1930 QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNM 1989

Query: 899  DAKQGSESPAQAGRESE-----ALKAQLEEERKRVARVQH----------ELEAQRSQLL 943
               +     A A  E +     +L+ +LE+        +H           LEA    + 
Sbjct: 1990 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 2049

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQ-LEGSLSRVKAQVEEEGKRRAG----------LQAD 992
             L T+   ++   ++V+    D + +  S +RV    +   KR  G          +Q  
Sbjct: 2050 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 2109

Query: 993  LEVAAQKVVQLESKRKTMQPHLLTK-EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
            L+ A  +   L SK   +  +L    +  Q   D      A     +    +     I+ 
Sbjct: 2110 LDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAV 2169

Query: 1052 RLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEE 1111
              + L+++L   +  +  +  + V  E  K++K  E++  A+   L  + D       ++
Sbjct: 2170 DPKNLQRQLEETKALQGQISSQQVAVE--KLKKTAEVLLDARGSLLPAKNDI------QK 2221

Query: 1112 AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL-------------LQESSRL--- 1155
             +  +  R EDL ++++    K+ +   + +    GL             L+E  ++   
Sbjct: 2222 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 2281

Query: 1156 RSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ----------LQERVHEIFQVDPE 1205
             + L++  +KN  L ++++   S  + + ++  K            LQ ++ ++     E
Sbjct: 2282 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 2341

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE------------YKEV 1253
               +     AK++E+  K    E   EKL   LE        V+             +E 
Sbjct: 2342 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 2401

Query: 1254 TQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            T E + H++  EVL  +      L E ++SHG   ++ + L+   +  ++ +   +T   
Sbjct: 2402 TSEFLEHKKHLEVLHSL------LKE-ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2454

Query: 1314 SKEVVR--HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVV 1371
             KE V    E+    +   + L+  ++E  +K    + +       + L + +K +EK  
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2514

Query: 1372 VQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE--------LEVQQLRAGVEE---QE 1420
            ++    T +  K+      L   +       + +         L  +      EE    +
Sbjct: 2515 LK----TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK 2570

Query: 1421 GLLSFQEDRSK--------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK-- 1470
            GL S ++D +          L ++ ++ +L  ++ +L+K     +   +M+ + K+ K  
Sbjct: 2571 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE--ESSAMMQWLQKMNKTA 2628

Query: 1471 ----DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                       TEA++  ++Q K+   EL +    +Q   D L +   +      +    
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN----PDTPEA 2684

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586
             + + +  E    W+ LN+    RQ + EE+     +    E   + W  E+  +     
Sbjct: 2685 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV-- 2742

Query: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRG 1635
                  G L  +   L  Q+QQ  + LQE     ++K + E+  AA +G
Sbjct: 2743 -----LGPLSIDPNMLNTQRQQVQILLQE---FATRKPQYEQLTAAGQG 2783



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 115/557 (20%), Positives = 229/557 (41%), Gaps = 102/557 (18%)

Query: 1209 EITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEV 1266
            EI R++A    +A  ++ +  E +++L +L     Q    ++ E +QE  V       ++
Sbjct: 1163 EIDRIRAS--NVASIKTMLPGEHQQVLSNL-----QSRFEDFLEDSQESQVFSGSDITQL 1215

Query: 1267 LREIDRLKAQLNELVNSHGRSQEQ--------------LIRLQGERDEWRRE-RAKVETK 1311
             +E++  K    EL+ S  R +++               +RL+   D   R+ R  +E  
Sbjct: 1216 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD 1275

Query: 1312 TVSKEVVRHEKDPVLEKEAERLRQEVREAAQK------RRAAEDAVYELQSK-------- 1357
             + + V R  +   L+KE ERL+ ++     K      + AA  +V  L+S+        
Sbjct: 1276 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 1335

Query: 1358 -------RLLLERRKPEEKVV----VQEVVVTQKDPKLREEHSRLSGSLD---------- 1396
                      +++ K    V+      E +V   + KL EE + ++   +          
Sbjct: 1336 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1395

Query: 1397 --EEVGRRRQ----LELEVQQLRAGVEE-----QEGLLSFQEDRSK-KLAVERELR---Q 1441
               EV  +RQ    LE E+Q+ +A  +E     +E  L F   + K    VER      Q
Sbjct: 1396 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1455

Query: 1442 LTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQ 1491
            +  R+++LE    +++          + I   E  + +   +  ++++ L   L+Q+K  
Sbjct: 1456 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1515

Query: 1492 VTELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTAR 1550
            V+E+  +    Q ++D  QK A+    T+    ++    R + D + +      R +++ 
Sbjct: 1516 VSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1571

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
                +E   LR R     TL   + +           A     RL++E ++LE +K++  
Sbjct: 1572 DLIIQEFMDLRTRYTALVTLMTQYIK----------FAGDSLKRLEEEEKSLEEEKKEHV 1621

Query: 1611 LQLQEESKLLS--QKTESERQKAAQRGQELSRLEA-AILREKDQIYEKERTLRDLHAKVS 1667
             + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  +T++   AK  
Sbjct: 1622 EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1681

Query: 1668 REELSQETQTRETNLST 1684
             +   +E    E  + T
Sbjct: 1682 DKMTDEERNELEKQVKT 1698



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 69/374 (18%), Positives = 143/374 (38%), Gaps = 52/374 (13%)

Query: 471  DPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
            +  A   AS L ++L+ L Q+   V           L  ++Q     D A  QA+    +
Sbjct: 4538 ESSAGEEASNLQNKLEVLNQRWQNV-----------LEKTEQRKQQLDGALRQAKGFHGE 4586

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTP--LEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            +  L   L   ER +LA      S+P     E  + +++ H       ++     ++  +
Sbjct: 4587 IEDLQQWLTDTERHLLA------SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4640

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
            + +  L+  P   A   +   +N++K K+  V+   +    K + AL+L  +  ++ +  
Sbjct: 4641 KGQQMLARCPKS-AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4699

Query: 649  RGFEATLVQEAPIPAEPGALQERV-----------SELQRQRRELLEQQTCVLRLHRALK 697
              +     Q   + + P  + + V           +E+   R +++E            K
Sbjct: 4700 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD----------K 4749

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
               H     Q       QD+   +  + ++  R+  V  +L  R + + DA    +QF  
Sbjct: 4750 TGTHLKYFSQK------QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803

Query: 758  CKDNLSSWLEHLPR---SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQAL 814
                L  WLE   +   S++  ++ P +I  +L   K   + + ++     T +   ++L
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863

Query: 815  --QAALQDYELQAD 826
              + +L D  L+ D
Sbjct: 4864 KEKTSLADDNLKLD 4877



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 17/175 (9%)

Query: 38   ELALLISRMQANADQVE--RDILETQKRLQQ---------DRLNSEQSQALQHQQETGRS 86
            E   +IS++ A A + E  R   E  ++L++         D++N    Q L+     G S
Sbjct: 4047 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 4106

Query: 87   LKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDV 146
            ++E  V    L+  + +  + +    +E      Q H+++ Q       + E++  PP +
Sbjct: 4107 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4166

Query: 147  GPRVDWAR--VLEQKQKQVCAGQYGPGMAEL----EQQIAEHNILQKEIDAYGQQ 195
               V+  +  + E K   V   +  P    L    E+ IA      K+I A   Q
Sbjct: 4167 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 564 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 623

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 624 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 664


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  211 bits (537), Expect = 6e-54
 Identities = 263/1302 (20%), Positives = 538/1302 (41%), Gaps = 157/1302 (12%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 615  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 674

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 675  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 734

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 735  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 793

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 794  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 853

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 854  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 913

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 914  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 973

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 974  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1033

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 1034 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1093

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 1094 LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1152

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 1153 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1212

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 1213 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1272

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 1273 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1332

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1333 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1391

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELS-EDIRRTH--------- 898
              + I  +  +L   YT +     Q ++    + K LE++E S E+ ++ H         
Sbjct: 1392 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1451

Query: 899  ----------DAKQGSESPAQAGR-ESEALKAQLEEERKRVARVQHEL--------EAQR 939
                      DA++  + P    +  SE +  + E+  + +  +Q  L        + +R
Sbjct: 1452 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1511

Query: 940  SQL-LQLRTQRPLERLEEKEVVEFYRDPQLEGSL---SRVKAQVEEEGKRRAGLQADLEV 995
            ++L  Q++T +    L   E ++  ++ Q  G +    ++ A+ ++E K +  LQ   ++
Sbjct: 1512 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEK--LQGICDL 1569

Query: 996  AAQKVVQLESKRKTMQ-----PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVIS 1050
              Q   +L   ++          L   +  Q E    +   A  L   ++          
Sbjct: 1570 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1629

Query: 1051 ARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE 1110
             +L    K L+  +  E  +K + +  +  + +K L+ V    A++ + E+ AA  KQ E
Sbjct: 1630 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV-VTTAIKEETEKVAA-VKQLE 1687

Query: 1111 EAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLA 1170
            E+  K++  ++ L       E +   K  + +EQ+    QE     ++ EE+      L 
Sbjct: 1688 ESKTKIENLLDWLSNVDKDSE-RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE 1746

Query: 1171 REL--------SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
             ++         +L+ +Y  V+ Q  K+  Q   H+   +  ++ Q        L E  G
Sbjct: 1747 TDVDGQVGTTQENLNQQYQKVKAQHEKIISQ---HQAVIIATQSAQ-------VLLEKQG 1796

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVN 1282
            +    E E EKL  +++ L+    T   +   +  + H     +  E+++  A   E  +
Sbjct: 1797 QYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEH 1851

Query: 1283 SHGRSQEQLIRLQGERDEWRRERAKVE-TKTVSKEVVRHEKD 1323
               +S+++L  L+   D+      K++  K+ S++V+ H+ D
Sbjct: 1852 WLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1893



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 261/1457 (17%), Positives = 557/1457 (38%), Gaps = 198/1457 (13%)

Query: 336  RRFQEEADSVSQTLAKLNSNLDA-KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGD 394
            ++ QEE+ ++ Q L K+N      + +PAP       T++ +Q ++ E  L        +
Sbjct: 2430 QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQV-EQNKSFEAELKQNVNKVQE 2488

Query: 395  LQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSG--EVQLLQGERYKLVDNTDPHAWVVQG 452
            L+ +  ++  L +  + P+ P     + + DS   E+  L  +R + ++ +  +    Q 
Sbjct: 2489 LKDKLTEL--LEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2546

Query: 453  PGGETKR---APAACFCIPAP---DPDAVARASRLASELQALKQKLATVQ---SRLKASA 503
               + K+          +  P   DP+ +   +    ++Q L Q+ AT +    +L A+ 
Sbjct: 2547 VEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQILLQEFATRKPQYEQLTAAG 2603

Query: 504  VESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ----IERQVLA---WARAPLSRP 556
               L    + PS   +   Q   +  +   L G L      I++ ++    +     S  
Sbjct: 2604 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2663

Query: 557  TPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE-----------------CEAFLSTRPV 599
              L DL+ ++ S    +    ++  + ETAQK                  CE   +    
Sbjct: 2664 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE 2723

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEA 659
                 +L   L  +   F DV+     + +  ++A     Q Q   R  + +  T  +E 
Sbjct: 2724 EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQ 2783

Query: 660  ----PIPAEPGALQERVSELQRQRRELLEQ-----QTCVLRLHRALKASEHACAALQNNF 710
                PI A+   L+  + + +   + L  Q     +T     +  LK      AALQ   
Sbjct: 2784 NKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQL 2843

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
                 +     +QV+   +R + + + L+   K  +     +     C++NL        
Sbjct: 2844 NTIKTNWDTFNKQVK---ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-----I 2895

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            +  + P++G + IA     QK + Q     E    TA+ L   L     D E+  D  + 
Sbjct: 2896 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL---LSVCEIDKEVVTDENKS 2952

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQE---KNLAKAYTEVAAAQQQLLQQLEFARKMLEK 887
             ++           +V  + E + +++   +N+ + + E     ++  +QL+ A++ L+ 
Sbjct: 2953 LIQ-----------KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3000

Query: 888  KELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRT 947
                      HD+  GS++       S      L+ ++K +  ++H+++  +        
Sbjct: 3001 ---------IHDS-LGSQA------YSNKYLTMLQTQQKSLQALKHQVDLAK-------- 3036

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKR 1007
                 RL +  VVE           S V  QVE   +  + L   ++   +K   LE+K 
Sbjct: 3037 -----RLAQDLVVE----ASDSKGTSDVLLQVETIAQEHSTLSQQVD---EKCSFLETKL 3084

Query: 1008 KTMQ--PHLLTKEVTQ-VERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALE 1064
            + +    + + +  +Q  E D  LDS A   R   + L+ +   I A L+ L+  + + +
Sbjct: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-DAETLQKQKETIKAFLKKLEALMASND 3143

Query: 1065 KREVDVKEKVVVKE----VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
                  K  +  +E    +V ++++LE                A  KQ  + + + QAR 
Sbjct: 3144 NANKTCKMMLATEETSPDLVGIKRDLE----------------ALSKQCNKLLDRAQARE 3187

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
            E +E  I            K++E+    L+E S L    EE       +  E   ++   
Sbjct: 3188 EQVEGTI------------KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ-- 3233

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK------L 1234
                        Q  + ++FQ     ++EI  L+ K Q++     G+ +   K      L
Sbjct: 3234 ------------QLNMFKVFQ-----KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
              DL+ + A+  T+  K+V Q   R  +  E L    R +  L  L++    ++E +   
Sbjct: 3277 EHDLDDVNARWKTLN-KKVAQ---RAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3332

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKD--PVLEKEAERLRQEVREAAQKRRAAEDAVY 1352
            +    E++  +A+++ + + + ++   K    V+++E E++     E A K +  +    
Sbjct: 3333 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI-ATTAEPADKVKILKQLSL 3391

Query: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL 1412
                   LL + +   + +    VV Q+  +  E  +    ++++ +     +  +  +L
Sbjct: 3392 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3451

Query: 1413 RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472
               + + + L     + +K L     + Q +L++    +    VQ K+   +V  +E   
Sbjct: 3452 EEQIAQHKALEDDIINHNKHLHQAVSIGQ-SLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510

Query: 1473 DLEKSTEALRWDLDQEK---TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE--VIRVQ 1527
                 +E L+  L   K       EL      +  ++  L       + ++K+   +RV 
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570

Query: 1528 KDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQ 1587
            ++ +L  ++     +LN     +Q   +E   ++++++  +   +  ++  +++ +  +Q
Sbjct: 3571 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3630

Query: 1588 ADQECGRLQQELRALERQKQQQTLQ-LQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646
            A Q   RL      L     +  ++ L  E+++L  +  S+ Q   +  ++ ++   A+L
Sbjct: 3631 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3690

Query: 1647 REKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
               +++      L    A+   E++  E   R   +S  I+             E     
Sbjct: 3691 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT----------QKVEEIDAA 3740

Query: 1707 IIDRGQYLQLQELECDW 1723
            I+   Q+ Q  + E  W
Sbjct: 3741 ILRSQQFDQAADAELSW 3757



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 157/867 (18%), Positives = 343/867 (39%), Gaps = 98/867 (11%)

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QR++   TDR+ ++  + ++    ++D    YQ +++    L + L+             
Sbjct: 1929 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ------------- 1975

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
               A +  A K L++ I    ++       ++ALQ  +   ++  +     L+ T  V  
Sbjct: 1976 ---ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE----KLKKTAEVLL 2028

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLE--FARKMLEKKELSEDIRRTH 898
              R  + P +  IQ    ++   Y +++ +  +  ++L+    R +  +  L E +    
Sbjct: 2029 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG 2088

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-K 957
            + +   +   Q    S AL+  + +       ++ ++  ++S +  +      E++++  
Sbjct: 2089 NVESSLKEQGQVPLNSTALQDIISKN----IMLEQDIAGRQSSINAMN-----EKVKKFM 2139

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E  +      L+  +  + A+  E   +     A +E    KV   E+  + +Q  L TK
Sbjct: 2140 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2199

Query: 1018 EVTQVERD-PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                 E D PG D    +L   +Q+   E       LE L   L  +    +   + +V+
Sbjct: 2200 TQALTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVL 2257

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAK-LQARIEDLERAISSVEPKVI 1135
            ++   + K  + ++     + +       +  A + + K L++ I++  + +  V+P   
Sbjct: 2258 EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 2317

Query: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNA------------TLARELSDLHSKYSVV 1183
             +++ K  +D   LQE   L++  E ++  N+            T A+ ++ + S  +V+
Sbjct: 2318 AEDLGKSLEDTKKLQEKWSLKT-PEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2376

Query: 1184 EKQRPKVQLQE---------RVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
              +      +E            ++  +    E     LK K+ E+  K S ++K  E+ 
Sbjct: 2377 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEES 2436

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
               ++ L+    T    + T      E     + +    +A+L + VN     +++L  L
Sbjct: 2437 SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL 2496

Query: 1295 QGERDE------WRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAE 1348
              E  +      W++   ++++K                   + L Q   +  QK   + 
Sbjct: 2497 LEENPDTPEAPRWKQMLTEIDSKW------------------QELNQLTIDRQQKLEESS 2538

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK-LREEHSRLSGSLDEEVGRRRQLEL 1407
            + + + Q+    L++   E++++V  +     DP  L  +  ++   L E   R+ Q E 
Sbjct: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE- 2597

Query: 1408 EVQQLRAGVEEQEGLLSFQ-EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKI--IMEE 1464
              Q   AG    +G+LS   ED S +  V+ +L  +T   Q+ +     + ++   I + 
Sbjct: 2598 --QLTAAG----QGILSRPGEDPSLRGIVKEQLAAVT---QKWDSLTGQLSDRCDWIDQA 2648

Query: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
            +VK  +   L +S      DLD + +    ++     +  Q++  QK K QE    K+ I
Sbjct: 2649 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK-QEIQQEKKQI 2707

Query: 1525 RVQKDRVLEDERARVWEMLNRERTARQ 1551
            +V +  + ED  A V E   +   +RQ
Sbjct: 2708 KVAQ-ALCEDLSALVKEEYLKAELSRQ 2733



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 222/1120 (19%), Positives = 441/1120 (39%), Gaps = 191/1120 (17%)

Query: 495  VQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLS 554
            VQS+L  S V  +   +++ S S+L        L Q        G+ E +++ W      
Sbjct: 3494 VQSKLDFSQVWYIEIQEKSHSRSEL--------LQQALCNAKIFGEDEVELMNWLNEVHD 3545

Query: 555  RPTPLEDLEGRIHSHEGTAQRLQSLGTEKETA----QKECEAFLS-----TRPVGPAALQ 605
            +   L  L  + +S EG  ++   L   +E      Q   +A L+      +  G   L 
Sbjct: 3546 K---LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3602

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
            +   L ++K ++ D+  L +   +  + AL L R++      +  +    V+   +  E 
Sbjct: 3603 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTW-LDKVEVELLSYET 3661

Query: 666  GALQ-ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQV 724
              L+ E  S+ Q + +EL ++      L  +L  +E + A L+       + L   ++ V
Sbjct: 3662 QVLKGEEASQAQMRPKELKKEAKNNKALLDSL--NEVSSALLELVPWRAREGL---EKMV 3716

Query: 725  RALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD---GPS 781
                +RY  V D +  + + +  A L  QQF    D   SW+    +  +   D      
Sbjct: 3717 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3776

Query: 782  QIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAP 841
            Q + +LQ QK  T EI                    L+  ++  D  +   +   A S  
Sbjct: 3777 QTSAQLQVQKTFTMEI--------------------LRHKDIIDDLVKSGHKIMTACSEE 3816

Query: 842  KRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK-----KELSEDIRR 896
            ++       +S++ +   + K Y  +     +   QLE A+ ++ +     +EL   +  
Sbjct: 3817 EK-------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3869

Query: 897  THDAKQGSESPAQAGRESEALKAQLEEERK-RVARVQH-----ELEAQRSQLLQLRTQRP 950
            T        +PA    E E L+ Q EE R+ R    +H     ++     QLL+L     
Sbjct: 3870 TQSIISQLPAPA---LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926

Query: 951  LERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTM 1010
               ++EK V           +   + +Q++E+ K+RA     L+ A  +  Q   K   +
Sbjct: 3927 FS-IQEKYV-----------AADTLYSQIKEDVKKRA---VALDEAISQSTQFHDKIDQI 3971

Query: 1011 QPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDV 1070
                L + V ++ + P + ++  +++ QI     E+  +S  +E L+     L++R  ++
Sbjct: 3972 L-ESLERIVERLRQPPSISAEVEKIKEQI----SENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 1071 ------KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
                   +K +  + V+ +K  +MV   + +   +EE  A+     E   K     + + 
Sbjct: 4027 IARSGGTDKDISAKAVQ-DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC--DHMS 4083

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVE 1184
              ++  + +  ++++    +DPG+        S++++++    T+  E+  L  +  +V 
Sbjct: 4084 LIVTIKDTQDFIRDL----EDPGIDP------SVVKQQQEAAETIREEIDGLQEELDIV- 4132

Query: 1185 KQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
                 + L     E+     E ++ I  +K  + E+      + K  +  +  LE   A 
Sbjct: 4133 -----INLGS---ELIAACGEPDKPI--VKKSIDELNSAWDSLNKAWKDRIDKLE--EAM 4180

Query: 1245 KPTVEYKEVTQEVV--------RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            +  V+Y++  Q V         +      +  +++ +K Q+ EL      + +Q I +  
Sbjct: 4181 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEM-- 4238

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHE-KDPVLEKE------AERL--RQEVREAA-----Q 1342
               E    +A++  K V++E  +H  +DP++E +       ER+  RQ   E A     Q
Sbjct: 4239 ---ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295

Query: 1343 KRRAAEDAVYELQSKRLLLERRKP-------------EEKVVVQEVVVTQK--------- 1380
             + A ++ +  L     LL  +KP             +  V+  +V+  Q          
Sbjct: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4355

Query: 1381 ----DPKLREEHSRLSGSLDEEVGRRRQLELE-----VQQLRAGVEEQEGLLSFQEDRSK 1431
                +    EE S L   L E + +R Q  LE      QQL   + + +G     ED  +
Sbjct: 4356 NDLIESSAGEEASNLQNKL-EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQ 4414

Query: 1432 KLA-VERELRQLTLRIQELEKRPPTVQEK--IIMEEVVKLEKDPDLEKS--TEALRWDLD 1486
             L   ER L    L  + L   P T +E+  + ME     E   +  KS   +  +    
Sbjct: 4415 WLTDTERHL----LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4470

Query: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
              K+  T ++++  NL+ + + ++   ++ KT  +E + +
Sbjct: 4471 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNL 4510



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 158/889 (17%), Positives = 337/889 (37%), Gaps = 133/889 (14%)

Query: 845  RVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKK------ELSEDIRRTH 898
            +V   QE++  Q + +   + ++ +  Q ++   + A+ +LEK+      E  E +++  
Sbjct: 1752 QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNM 1811

Query: 899  DAKQGSESPAQAGRESE-----ALKAQLEEERKRVARVQH----------ELEAQRSQLL 943
               +     A A  E +     +L+ +LE+        +H           LEA    + 
Sbjct: 1812 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1871

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQ-LEGSLSRVKAQVEEEGKRRAG----------LQAD 992
             L T+   ++   ++V+    D + +  S +RV    +   KR  G          +Q  
Sbjct: 1872 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1931

Query: 993  LEVAAQKVVQLESKRKTMQPHLLTK-EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
            L+ A  +   L SK   +  +L    +  Q   D      A     +    +     I+ 
Sbjct: 1932 LDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAV 1991

Query: 1052 RLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEE 1111
              + L+++L   +  +  +  + V  E  K++K  E++  A+   L  + D       ++
Sbjct: 1992 DPKNLQRQLEETKALQGQISSQQVAVE--KLKKTAEVLLDARGSLLPAKNDI------QK 2043

Query: 1112 AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL-------------LQESSRL--- 1155
             +  +  R EDL ++++    K+ +   + +    GL             L+E  ++   
Sbjct: 2044 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 2103

Query: 1156 RSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ----------LQERVHEIFQVDPE 1205
             + L++  +KN  L ++++   S  + + ++  K            LQ ++ ++     E
Sbjct: 2104 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 2163

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE------------YKEV 1253
               +     AK++E+  K    E   EKL   LE        V+             +E 
Sbjct: 2164 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 2223

Query: 1254 TQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            T E + H++  EVL  +      L E ++SHG   ++ + L+   +  ++ +   +T   
Sbjct: 2224 TSEFLEHKKHLEVLHSL------LKE-ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276

Query: 1314 SKEVVR--HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVV 1371
             KE V    E+    +   + L+  ++E  +K    + +       + L + +K +EK  
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2336

Query: 1372 VQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE--------LEVQQLRAGVEE---QE 1420
            ++    T +  K+      L   +       + +         L  +      EE    +
Sbjct: 2337 LK----TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK 2392

Query: 1421 GLLSFQEDRSK--------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK-- 1470
            GL S ++D +          L ++ ++ +L  ++ +L+K     +   +M+ + K+ K  
Sbjct: 2393 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE--ESSAMMQWLQKMNKTA 2450

Query: 1471 ----DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                       TEA++  ++Q K+   EL +    +Q   D L +   +      +    
Sbjct: 2451 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN----PDTPEA 2506

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586
             + + +  E    W+ LN+    RQ + EE+     +    E   + W  E+  +     
Sbjct: 2507 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV-- 2564

Query: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRG 1635
                  G L  +   L  Q+QQ  + LQE     ++K + E+  AA +G
Sbjct: 2565 -----LGPLSIDPNMLNTQRQQVQILLQE---FATRKPQYEQLTAAGQG 2605



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 115/557 (20%), Positives = 229/557 (41%), Gaps = 102/557 (18%)

Query: 1209 EITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEV 1266
            EI R++A    +A  ++ +  E +++L +L     Q    ++ E +QE  V       ++
Sbjct: 985  EIDRIRAS--NVASIKTMLPGEHQQVLSNL-----QSRFEDFLEDSQESQVFSGSDITQL 1037

Query: 1267 LREIDRLKAQLNELVNSHGRSQEQ--------------LIRLQGERDEWRRE-RAKVETK 1311
             +E++  K    EL+ S  R +++               +RL+   D   R+ R  +E  
Sbjct: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD 1097

Query: 1312 TVSKEVVRHEKDPVLEKEAERLRQEVREAAQK------RRAAEDAVYELQSK-------- 1357
             + + V R  +   L+KE ERL+ ++     K      + AA  +V  L+S+        
Sbjct: 1098 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 1157

Query: 1358 -------RLLLERRKPEEKVV----VQEVVVTQKDPKLREEHSRLSGSLD---------- 1396
                      +++ K    V+      E +V   + KL EE + ++   +          
Sbjct: 1158 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1217

Query: 1397 --EEVGRRRQ----LELEVQQLRAGVEE-----QEGLLSFQEDRSK-KLAVERELR---Q 1441
               EV  +RQ    LE E+Q+ +A  +E     +E  L F   + K    VER      Q
Sbjct: 1218 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1277

Query: 1442 LTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQ 1491
            +  R+++LE    +++          + I   E  + +   +  ++++ L   L+Q+K  
Sbjct: 1278 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1337

Query: 1492 VTELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTAR 1550
            V+E+  +    Q ++D  QK A+    T+    ++    R + D + +      R +++ 
Sbjct: 1338 VSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1393

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
                +E   LR R     TL   + +           A     RL++E ++LE +K++  
Sbjct: 1394 DLIIQEFMDLRTRYTALVTLMTQYIK----------FAGDSLKRLEEEEKSLEEEKKEHV 1443

Query: 1611 LQLQEESKLLS--QKTESERQKAAQRGQELSRLEA-AILREKDQIYEKERTLRDLHAKVS 1667
             + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  +T++   AK  
Sbjct: 1444 EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1503

Query: 1668 REELSQETQTRETNLST 1684
             +   +E    E  + T
Sbjct: 1504 DKMTDEERNELEKQVKT 1520



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 69/374 (18%), Positives = 143/374 (38%), Gaps = 52/374 (13%)

Query: 471  DPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
            +  A   AS L ++L+ L Q+   V           L  ++Q     D A  QA+    +
Sbjct: 4360 ESSAGEEASNLQNKLEVLNQRWQNV-----------LEKTEQRKQQLDGALRQAKGFHGE 4408

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTP--LEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            +  L   L   ER +LA      S+P     E  + +++ H       ++     ++  +
Sbjct: 4409 IEDLQQWLTDTERHLLA------SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4462

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
            + +  L+  P   A   +   +N++K K+  V+   +    K + AL+L  +  ++ +  
Sbjct: 4463 KGQQMLARCPKS-AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4521

Query: 649  RGFEATLVQEAPIPAEPGALQERV-----------SELQRQRRELLEQQTCVLRLHRALK 697
              +     Q   + + P  + + V           +E+   R +++E            K
Sbjct: 4522 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD----------K 4571

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
               H     Q       QD+   +  + ++  R+  V  +L  R + + DA    +QF  
Sbjct: 4572 TGTHLKYFSQK------QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625

Query: 758  CKDNLSSWLEHLPR---SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQAL 814
                L  WLE   +   S++  ++ P +I  +L   K   + + ++     T +   ++L
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685

Query: 815  --QAALQDYELQAD 826
              + +L D  L+ D
Sbjct: 4686 KEKTSLADDNLKLD 4699



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 17/175 (9%)

Query: 38   ELALLISRMQANADQVE--RDILETQKRLQQ---------DRLNSEQSQALQHQQETGRS 86
            E   +IS++ A A + E  R   E  ++L++         D++N    Q L+     G S
Sbjct: 3869 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3928

Query: 87   LKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDV 146
            ++E  V    L+  + +  + +    +E      Q H+++ Q       + E++  PP +
Sbjct: 3929 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 3988

Query: 147  GPRVDWAR--VLEQKQKQVCAGQYGPGMAEL----EQQIAEHNILQKEIDAYGQQ 195
               V+  +  + E K   V   +  P    L    E+ IA      K+I A   Q
Sbjct: 3989 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 386 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 445

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 446 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 486


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  211 bits (537), Expect = 6e-54
 Identities = 263/1302 (20%), Positives = 538/1302 (41%), Gaps = 157/1302 (12%)

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRS-------LVGPDAAT-- 206
            +++ Q Q+   ++G  +  +E  +  H  + + I+ +   L+        +  P   T  
Sbjct: 289  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 348

Query: 207  -----IRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADP 261
                 + SQY  LL  +  + + L +L+  +   T +L  L E++   +  DWS+   + 
Sbjct: 349  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408

Query: 262  AGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNL 321
            A  +++Y      EL  +E+++  +++  E+++   HPA   I+A++ A++ +W   L L
Sbjct: 409  AR-KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQL 467

Query: 322  CICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
            C C E  ++    Y  F  +A   +  L  L   +  KYS           +L+Q+   E
Sbjct: 468  CQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEE 527

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRN--PPQQPLHVDSICDWDSGEVQLLQGERYKL 439
            ++ L   +    +L  +++ +  L  R +  P +  + + +ICD+   E+ + + +   L
Sbjct: 528  KEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587

Query: 440  VDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL------------------ 481
             +N+    W V  P G     P+ CF +P P+ +AV  A+R+                  
Sbjct: 588  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647

Query: 482  -----------------ASELQALKQKLA----TVQSRLKASAVESLRPSQQAP--SGSD 518
                             AS + ++K  L      V S L++   + L  SQ++   SGSD
Sbjct: 648  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707

Query: 519  LANPQA---------QKLLTQMTRLDGD-----------------LGQIERQVLAWARAP 552
            +   +          Q+LL    R + +                 L   E +++   R P
Sbjct: 708  ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
            L R   L +   RI   E   + L+ L  +  T   +CE F S      +   L   LN 
Sbjct: 768  LERDD-LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            V    + V  + S Y +K K    + +  Q A+ +++ +E  L +E  + A+   ++  +
Sbjct: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
            S L++ R E+ E++     L   L+ ++     +   ++E   D    + +   L +R+ 
Sbjct: 887  STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQ----IAYKLQ 788
             V  Q+D R + ++    + + +++    L  W++ +  +Q +  +   +    +A +L 
Sbjct: 947  NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             QK L  EI+ ++         ++   A ++DYELQ  TYR  ++ +   S  KR R+  
Sbjct: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-SQQKSPVKRRRMQS 1065

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELS-EDIRRTH--------- 898
              + I  +  +L   YT +     Q ++    + K LE++E S E+ ++ H         
Sbjct: 1066 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1125

Query: 899  ----------DAKQGSESPAQAGR-ESEALKAQLEEERKRVARVQHEL--------EAQR 939
                      DA++  + P    +  SE +  + E+  + +  +Q  L        + +R
Sbjct: 1126 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1185

Query: 940  SQL-LQLRTQRPLERLEEKEVVEFYRDPQLEGSL---SRVKAQVEEEGKRRAGLQADLEV 995
            ++L  Q++T +    L   E ++  ++ Q  G +    ++ A+ ++E K +  LQ   ++
Sbjct: 1186 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEK--LQGICDL 1243

Query: 996  AAQKVVQLESKRKTMQ-----PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVIS 1050
              Q   +L   ++          L   +  Q E    +   A  L   ++          
Sbjct: 1244 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1303

Query: 1051 ARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE 1110
             +L    K L+  +  E  +K + +  +  + +K L+ V    A++ + E+ AA  KQ E
Sbjct: 1304 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV-VTTAIKEETEKVAA-VKQLE 1361

Query: 1111 EAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLA 1170
            E+  K++  ++ L       E +   K  + +EQ+    QE     ++ EE+      L 
Sbjct: 1362 ESKTKIENLLDWLSNVDKDSE-RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE 1420

Query: 1171 REL--------SDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
             ++         +L+ +Y  V+ Q  K+  Q   H+   +  ++ Q        L E  G
Sbjct: 1421 TDVDGQVGTTQENLNQQYQKVKAQHEKIISQ---HQAVIIATQSAQ-------VLLEKQG 1470

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVN 1282
            +    E E EKL  +++ L+    T   +   +  + H     +  E+++  A   E  +
Sbjct: 1471 QYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEH 1525

Query: 1283 SHGRSQEQLIRLQGERDEWRRERAKVE-TKTVSKEVVRHEKD 1323
               +S+++L  L+   D+      K++  K+ S++V+ H+ D
Sbjct: 1526 WLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1567



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 261/1457 (17%), Positives = 557/1457 (38%), Gaps = 198/1457 (13%)

Query: 336  RRFQEEADSVSQTLAKLNSNLDA-KYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGD 394
            ++ QEE+ ++ Q L K+N      + +PAP       T++ +Q ++ E  L        +
Sbjct: 2104 QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQV-EQNKSFEAELKQNVNKVQE 2162

Query: 395  LQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSG--EVQLLQGERYKLVDNTDPHAWVVQG 452
            L+ +  ++  L +  + P+ P     + + DS   E+  L  +R + ++ +  +    Q 
Sbjct: 2163 LKDKLTEL--LEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2220

Query: 453  PGGETKR---APAACFCIPAP---DPDAVARASRLASELQALKQKLATVQ---SRLKASA 503
               + K+          +  P   DP+ +   +    ++Q L Q+ AT +    +L A+ 
Sbjct: 2221 VEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQILLQEFATRKPQYEQLTAAG 2277

Query: 504  VESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQ----IERQVLA---WARAPLSRP 556
               L    + PS   +   Q   +  +   L G L      I++ ++    +     S  
Sbjct: 2278 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2337

Query: 557  TPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE-----------------CEAFLSTRPV 599
              L DL+ ++ S    +    ++  + ETAQK                  CE   +    
Sbjct: 2338 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE 2397

Query: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEA 659
                 +L   L  +   F DV+     + +  ++A     Q Q   R  + +  T  +E 
Sbjct: 2398 EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQ 2457

Query: 660  ----PIPAEPGALQERVSELQRQRRELLEQ-----QTCVLRLHRALKASEHACAALQNNF 710
                PI A+   L+  + + +   + L  Q     +T     +  LK      AALQ   
Sbjct: 2458 NKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQL 2517

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
                 +     +QV+   +R + + + L+   K  +     +     C++NL        
Sbjct: 2518 NTIKTNWDTFNKQVK---ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-----I 2569

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            +  + P++G + IA     QK + Q     E    TA+ L   L     D E+  D  + 
Sbjct: 2570 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL---LSVCEIDKEVVTDENKS 2626

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQE---KNLAKAYTEVAAAQQQLLQQLEFARKMLEK 887
             ++           +V  + E + +++   +N+ + + E     ++  +QL+ A++ L+ 
Sbjct: 2627 LIQ-----------KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 2674

Query: 888  KELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRT 947
                      HD+  GS++       S      L+ ++K +  ++H+++  +        
Sbjct: 2675 ---------IHDS-LGSQA------YSNKYLTMLQTQQKSLQALKHQVDLAK-------- 2710

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKR 1007
                 RL +  VVE           S V  QVE   +  + L   ++   +K   LE+K 
Sbjct: 2711 -----RLAQDLVVE----ASDSKGTSDVLLQVETIAQEHSTLSQQVD---EKCSFLETKL 2758

Query: 1008 KTMQ--PHLLTKEVTQ-VERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALE 1064
            + +    + + +  +Q  E D  LDS A   R   + L+ +   I A L+ L+  + + +
Sbjct: 2759 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-DAETLQKQKETIKAFLKKLEALMASND 2817

Query: 1065 KREVDVKEKVVVKE----VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
                  K  +  +E    +V ++++LE                A  KQ  + + + QAR 
Sbjct: 2818 NANKTCKMMLATEETSPDLVGIKRDLE----------------ALSKQCNKLLDRAQARE 2861

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
            E +E  I            K++E+    L+E S L    EE       +  E   ++   
Sbjct: 2862 EQVEGTI------------KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ-- 2907

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEK------L 1234
                        Q  + ++FQ     ++EI  L+ K Q++     G+ +   K      L
Sbjct: 2908 ------------QLNMFKVFQ-----KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
              DL+ + A+  T+  K+V Q   R  +  E L    R +  L  L++    ++E +   
Sbjct: 2951 EHDLDDVNARWKTLN-KKVAQ---RAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ 3006

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKD--PVLEKEAERLRQEVREAAQKRRAAEDAVY 1352
            +    E++  +A+++ + + + ++   K    V+++E E++     E A K +  +    
Sbjct: 3007 KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI-ATTAEPADKVKILKQLSL 3065

Query: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQL 1412
                   LL + +   + +    VV Q+  +  E  +    ++++ +     +  +  +L
Sbjct: 3066 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3125

Query: 1413 RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP 1472
               + + + L     + +K L     + Q +L++    +    VQ K+   +V  +E   
Sbjct: 3126 EEQIAQHKALEDDIINHNKHLHQAVSIGQ-SLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184

Query: 1473 DLEKSTEALRWDLDQEK---TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKE--VIRVQ 1527
                 +E L+  L   K       EL      +  ++  L       + ++K+   +RV 
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244

Query: 1528 KDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQ 1587
            ++ +L  ++     +LN     +Q   +E   ++++++  +   +  ++  +++ +  +Q
Sbjct: 3245 QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQ 3304

Query: 1588 ADQECGRLQQELRALERQKQQQTLQ-LQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646
            A Q   RL      L     +  ++ L  E+++L  +  S+ Q   +  ++ ++   A+L
Sbjct: 3305 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3364

Query: 1647 REKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
               +++      L    A+   E++  E   R   +S  I+             E     
Sbjct: 3365 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT----------QKVEEIDAA 3414

Query: 1707 IIDRGQYLQLQELECDW 1723
            I+   Q+ Q  + E  W
Sbjct: 3415 ILRSQQFDQAADAELSW 3431



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 157/867 (18%), Positives = 343/867 (39%), Gaps = 98/867 (11%)

Query: 721  QRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGP 780
            QR++   TDR+ ++  + ++    ++D    YQ +++    L + L+             
Sbjct: 1603 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQ------------- 1649

Query: 781  SQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSA 840
               A +  A K L++ I    ++       ++ALQ  +   ++  +     L+ T  V  
Sbjct: 1650 ---ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE----KLKKTAEVLL 1702

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLE--FARKMLEKKELSEDIRRTH 898
              R  + P +  IQ    ++   Y +++ +  +  ++L+    R +  +  L E +    
Sbjct: 1703 DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG 1762

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-K 957
            + +   +   Q    S AL+  + +       ++ ++  ++S +  +      E++++  
Sbjct: 1763 NVESSLKEQGQVPLNSTALQDIISKN----IMLEQDIAGRQSSINAMN-----EKVKKFM 1813

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E  +      L+  +  + A+  E   +     A +E    KV   E+  + +Q  L TK
Sbjct: 1814 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 1873

Query: 1018 EVTQVERD-PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVV 1076
                 E D PG D    +L   +Q+   E       LE L   L  +    +   + +V+
Sbjct: 1874 TQALTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVL 1931

Query: 1077 KEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAK-LQARIEDLERAISSVEPKVI 1135
            ++   + K  + ++     + +       +  A + + K L++ I++  + +  V+P   
Sbjct: 1932 EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG 1991

Query: 1136 VKEVKKVEQDPGLLQESSRLRSLLEEERTKNA------------TLARELSDLHSKYSVV 1183
             +++ K  +D   LQE   L++  E ++  N+            T A+ ++ + S  +V+
Sbjct: 1992 AEDLGKSLEDTKKLQEKWSLKT-PEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2050

Query: 1184 EKQRPKVQLQE---------RVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
              +      +E            ++  +    E     LK K+ E+  K S ++K  E+ 
Sbjct: 2051 NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEES 2110

Query: 1235 LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
               ++ L+    T    + T      E     + +    +A+L + VN     +++L  L
Sbjct: 2111 SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL 2170

Query: 1295 QGERDE------WRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAE 1348
              E  +      W++   ++++K                   + L Q   +  QK   + 
Sbjct: 2171 LEENPDTPEAPRWKQMLTEIDSKW------------------QELNQLTIDRQQKLEESS 2212

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK-LREEHSRLSGSLDEEVGRRRQLEL 1407
            + + + Q+    L++   E++++V  +     DP  L  +  ++   L E   R+ Q E 
Sbjct: 2213 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE- 2271

Query: 1408 EVQQLRAGVEEQEGLLSFQ-EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKI--IMEE 1464
              Q   AG    +G+LS   ED S +  V+ +L  +T   Q+ +     + ++   I + 
Sbjct: 2272 --QLTAAG----QGILSRPGEDPSLRGIVKEQLAAVT---QKWDSLTGQLSDRCDWIDQA 2322

Query: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
            +VK  +   L +S      DLD + +    ++     +  Q++  QK K QE    K+ I
Sbjct: 2323 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK-QEIQQEKKQI 2381

Query: 1525 RVQKDRVLEDERARVWEMLNRERTARQ 1551
            +V +  + ED  A V E   +   +RQ
Sbjct: 2382 KVAQ-ALCEDLSALVKEEYLKAELSRQ 2407



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 222/1120 (19%), Positives = 441/1120 (39%), Gaps = 191/1120 (17%)

Query: 495  VQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLS 554
            VQS+L  S V  +   +++ S S+L        L Q        G+ E +++ W      
Sbjct: 3168 VQSKLDFSQVWYIEIQEKSHSRSEL--------LQQALCNAKIFGEDEVELMNWLNEVHD 3219

Query: 555  RPTPLEDLEGRIHSHEGTAQRLQSLGTEKETA----QKECEAFLS-----TRPVGPAALQ 605
            +   L  L  + +S EG  ++   L   +E      Q   +A L+      +  G   L 
Sbjct: 3220 K---LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3276

Query: 606  LPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEP 665
            +   L ++K ++ D+  L +   +  + AL L R++      +  +    V+   +  E 
Sbjct: 3277 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTW-LDKVEVELLSYET 3335

Query: 666  GALQ-ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQV 724
              L+ E  S+ Q + +EL ++      L  +L  +E + A L+       + L   ++ V
Sbjct: 3336 QVLKGEEASQAQMRPKELKKEAKNNKALLDSL--NEVSSALLELVPWRAREGL---EKMV 3390

Query: 725  RALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSD---GPS 781
                +RY  V D +  + + +  A L  QQF    D   SW+    +  +   D      
Sbjct: 3391 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3450

Query: 782  QIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAP 841
            Q + +LQ QK  T EI                    L+  ++  D  +   +   A S  
Sbjct: 3451 QTSAQLQVQKTFTMEI--------------------LRHKDIIDDLVKSGHKIMTACSEE 3490

Query: 842  KRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK-----KELSEDIRR 896
            ++       +S++ +   + K Y  +     +   QLE A+ ++ +     +EL   +  
Sbjct: 3491 EK-------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3543

Query: 897  THDAKQGSESPAQAGRESEALKAQLEEERK-RVARVQH-----ELEAQRSQLLQLRTQRP 950
            T        +PA    E E L+ Q EE R+ R    +H     ++     QLL+L     
Sbjct: 3544 TQSIISQLPAPA---LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3600

Query: 951  LERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTM 1010
               ++EK V           +   + +Q++E+ K+RA     L+ A  +  Q   K   +
Sbjct: 3601 FS-IQEKYV-----------AADTLYSQIKEDVKKRA---VALDEAISQSTQFHDKIDQI 3645

Query: 1011 QPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDV 1070
                L + V ++ + P + ++  +++ QI     E+  +S  +E L+     L++R  ++
Sbjct: 3646 L-ESLERIVERLRQPPSISAEVEKIKEQI----SENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 1071 ------KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
                   +K +  + V+ +K  +MV   + +   +EE  A+     E   K     + + 
Sbjct: 3701 IARSGGTDKDISAKAVQ-DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC--DHMS 3757

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVE 1184
              ++  + +  ++++    +DPG+        S++++++    T+  E+  L  +  +V 
Sbjct: 3758 LIVTIKDTQDFIRDL----EDPGIDP------SVVKQQQEAAETIREEIDGLQEELDIV- 3806

Query: 1185 KQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
                 + L     E+     E ++ I  +K  + E+      + K  +  +  LE   A 
Sbjct: 3807 -----INLGS---ELIAACGEPDKPI--VKKSIDELNSAWDSLNKAWKDRIDKLE--EAM 3854

Query: 1245 KPTVEYKEVTQEVV--------RHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            +  V+Y++  Q V         +      +  +++ +K Q+ EL      + +Q I +  
Sbjct: 3855 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEM-- 3912

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHE-KDPVLEKE------AERL--RQEVREAA-----Q 1342
               E    +A++  K V++E  +H  +DP++E +       ER+  RQ   E A     Q
Sbjct: 3913 ---ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 3969

Query: 1343 KRRAAEDAVYELQSKRLLLERRKP-------------EEKVVVQEVVVTQK--------- 1380
             + A ++ +  L     LL  +KP             +  V+  +V+  Q          
Sbjct: 3970 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4029

Query: 1381 ----DPKLREEHSRLSGSLDEEVGRRRQLELE-----VQQLRAGVEEQEGLLSFQEDRSK 1431
                +    EE S L   L E + +R Q  LE      QQL   + + +G     ED  +
Sbjct: 4030 NDLIESSAGEEASNLQNKL-EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQ 4088

Query: 1432 KLA-VERELRQLTLRIQELEKRPPTVQEK--IIMEEVVKLEKDPDLEKS--TEALRWDLD 1486
             L   ER L    L  + L   P T +E+  + ME     E   +  KS   +  +    
Sbjct: 4089 WLTDTERHL----LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR 4144

Query: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
              K+  T ++++  NL+ + + ++   ++ KT  +E + +
Sbjct: 4145 CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNL 4184



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 158/889 (17%), Positives = 337/889 (37%), Gaps = 133/889 (14%)

Query: 845  RVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKK------ELSEDIRRTH 898
            +V   QE++  Q + +   + ++ +  Q ++   + A+ +LEK+      E  E +++  
Sbjct: 1426 QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNM 1485

Query: 899  DAKQGSESPAQAGRESE-----ALKAQLEEERKRVARVQH----------ELEAQRSQLL 943
               +     A A  E +     +L+ +LE+        +H           LEA    + 
Sbjct: 1486 KELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDIN 1545

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQ-LEGSLSRVKAQVEEEGKRRAG----------LQAD 992
             L T+   ++   ++V+    D + +  S +RV    +   KR  G          +Q  
Sbjct: 1546 GLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRK 1605

Query: 993  LEVAAQKVVQLESKRKTMQPHLLTK-EVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
            L+ A  +   L SK   +  +L    +  Q   D      A     +    +     I+ 
Sbjct: 1606 LDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAV 1665

Query: 1052 RLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEE 1111
              + L+++L   +  +  +  + V  E  K++K  E++  A+   L  + D       ++
Sbjct: 1666 DPKNLQRQLEETKALQGQISSQQVAVE--KLKKTAEVLLDARGSLLPAKNDI------QK 1717

Query: 1112 AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL-------------LQESSRL--- 1155
             +  +  R EDL ++++    K+ +   + +    GL             L+E  ++   
Sbjct: 1718 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 1777

Query: 1156 RSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ----------LQERVHEIFQVDPE 1205
             + L++  +KN  L ++++   S  + + ++  K            LQ ++ ++     E
Sbjct: 1778 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 1837

Query: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE------------YKEV 1253
               +     AK++E+  K    E   EKL   LE        V+             +E 
Sbjct: 1838 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 1897

Query: 1254 TQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTV 1313
            T E + H++  EVL  +      L E ++SHG   ++ + L+   +  ++ +   +T   
Sbjct: 1898 TSEFLEHKKHLEVLHSL------LKE-ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 1950

Query: 1314 SKEVVR--HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVV 1371
             KE V    E+    +   + L+  ++E  +K    + +       + L + +K +EK  
Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2010

Query: 1372 VQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE--------LEVQQLRAGVEE---QE 1420
            ++    T +  K+      L   +       + +         L  +      EE    +
Sbjct: 2011 LK----TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANK 2066

Query: 1421 GLLSFQEDRSK--------KLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEK-- 1470
            GL S ++D +          L ++ ++ +L  ++ +L+K     +   +M+ + K+ K  
Sbjct: 2067 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE--ESSAMMQWLQKMNKTA 2124

Query: 1471 ----DPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                       TEA++  ++Q K+   EL +    +Q   D L +   +      +    
Sbjct: 2125 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN----PDTPEA 2180

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARD 1586
             + + +  E    W+ LN+    RQ + EE+     +    E   + W  E+  +     
Sbjct: 2181 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV-- 2238

Query: 1587 QADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRG 1635
                  G L  +   L  Q+QQ  + LQE     ++K + E+  AA +G
Sbjct: 2239 -----LGPLSIDPNMLNTQRQQVQILLQE---FATRKPQYEQLTAAGQG 2279



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 115/557 (20%), Positives = 229/557 (41%), Gaps = 102/557 (18%)

Query: 1209 EITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEV 1266
            EI R++A    +A  ++ +  E +++L +L     Q    ++ E +QE  V       ++
Sbjct: 659  EIDRIRAS--NVASIKTMLPGEHQQVLSNL-----QSRFEDFLEDSQESQVFSGSDITQL 711

Query: 1267 LREIDRLKAQLNELVNSHGRSQEQ--------------LIRLQGERDEWRRE-RAKVETK 1311
             +E++  K    EL+ S  R +++               +RL+   D   R+ R  +E  
Sbjct: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD 771

Query: 1312 TVSKEVVRHEKDPVLEKEAERLRQEVREAAQK------RRAAEDAVYELQSK-------- 1357
             + + V R  +   L+KE ERL+ ++     K      + AA  +V  L+S+        
Sbjct: 772  DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831

Query: 1358 -------RLLLERRKPEEKVV----VQEVVVTQKDPKLREEHSRLSGSLD---------- 1396
                      +++ K    V+      E +V   + KL EE + ++   +          
Sbjct: 832  NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891

Query: 1397 --EEVGRRRQ----LELEVQQLRAGVEE-----QEGLLSFQEDRSK-KLAVERELR---Q 1441
               EV  +RQ    LE E+Q+ +A  +E     +E  L F   + K    VER      Q
Sbjct: 892  WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951

Query: 1442 LTLRIQELEKRPPTVQ----------EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQ 1491
            +  R+++LE    +++          + I   E  + +   +  ++++ L   L+Q+K  
Sbjct: 952  IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011

Query: 1492 VTELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTAR 1550
            V+E+  +    Q ++D  QK A+    T+    ++    R + D + +      R +++ 
Sbjct: 1012 VSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1067

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
                +E   LR R     TL   + +           A     RL++E ++LE +K++  
Sbjct: 1068 DLIIQEFMDLRTRYTALVTLMTQYIK----------FAGDSLKRLEEEEKSLEEEKKEHV 1117

Query: 1611 LQLQEESKLLS--QKTESERQKAAQRGQELSRLEA-AILREKDQIYEKERTLRDLHAKVS 1667
             + +E  K +S   KT  + +KA +      ++ +  I  +K+Q+ E  +T++   AK  
Sbjct: 1118 EKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1177

Query: 1668 REELSQETQTRETNLST 1684
             +   +E    E  + T
Sbjct: 1178 DKMTDEERNELEKQVKT 1194



 Score = 34.7 bits (78), Expect = 0.98
 Identities = 69/374 (18%), Positives = 143/374 (38%), Gaps = 52/374 (13%)

Query: 471  DPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQ 530
            +  A   AS L ++L+ L Q+   V           L  ++Q     D A  QA+    +
Sbjct: 4034 ESSAGEEASNLQNKLEVLNQRWQNV-----------LEKTEQRKQQLDGALRQAKGFHGE 4082

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTP--LEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            +  L   L   ER +LA      S+P     E  + +++ H       ++     ++  +
Sbjct: 4083 IEDLQQWLTDTERHLLA------SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4136

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
            + +  L+  P   A   +   +N++K K+  V+   +    K + AL+L  +  ++ +  
Sbjct: 4137 KGQQMLARCPKS-AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195

Query: 649  RGFEATLVQEAPIPAEPGALQERV-----------SELQRQRRELLEQQTCVLRLHRALK 697
              +     Q   + + P  + + V           +E+   R +++E            K
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD----------K 4245

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
               H     Q       QD+   +  + ++  R+  V  +L  R + + DA    +QF  
Sbjct: 4246 TGTHLKYFSQK------QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4299

Query: 758  CKDNLSSWLEHLPR---SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQAL 814
                L  WLE   +   S++  ++ P +I  +L   K   + + ++     T +   ++L
Sbjct: 4300 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359

Query: 815  --QAALQDYELQAD 826
              + +L D  L+ D
Sbjct: 4360 KEKTSLADDNLKLD 4373



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 17/175 (9%)

Query: 38   ELALLISRMQANADQVE--RDILETQKRLQQ---------DRLNSEQSQALQHQQETGRS 86
            E   +IS++ A A + E  R   E  ++L++         D++N    Q L+     G S
Sbjct: 3543 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3602

Query: 87   LKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDV 146
            ++E  V    L+  + +  + +    +E      Q H+++ Q       + E++  PP +
Sbjct: 3603 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 3662

Query: 147  GPRVDWAR--VLEQKQKQVCAGQYGPGMAEL----EQQIAEHNILQKEIDAYGQQ 195
               V+  +  + E K   V   +  P    L    E+ IA      K+I A   Q
Sbjct: 3663 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/101 (22%), Positives = 46/101 (45%)

Query: 39  LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
           L  + +R+Q ++   E  ++     LQ D    E     Q++ E    + E E LL+   
Sbjct: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119

Query: 99  LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
           +DV      K+ QA+++ + + +L + +     E  ++Y K
Sbjct: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  175 bits (443), Expect = 5e-43
 Identities = 191/840 (22%), Positives = 344/840 (40%), Gaps = 108/840 (12%)

Query: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 527  LQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLF 586

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 587  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 646

Query: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 647  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE 706

Query: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 707  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 766

Query: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 767  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 825

Query: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  K S  
Sbjct: 826  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCD 885

Query: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 886  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 945

Query: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +     +RL
Sbjct: 946  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005

Query: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1065

Query: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 1066 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1125

Query: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 1126 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1184

Query: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 1185 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1243

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 1244 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1303

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQ 773
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R Q
Sbjct: 1304 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1363


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  159 bits (403), Expect = 2e-38
 Identities = 237/1077 (22%), Positives = 469/1077 (43%), Gaps = 142/1077 (13%)

Query: 792  RLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSL-EPTLAVSAPKRPRVAPLQ 850
            R  QE Q RE  RA    L        +++  +    R  L E        K+ +    Q
Sbjct: 175  RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234

Query: 851  ESI--QAQEKNLAKAYTEVAAAQQQL----------LQQLEFARKMLEKKELSEDIRRTH 898
            + +  + +EK   K  T +   +++L          LQ+ E   + LE++EL  + +   
Sbjct: 235  DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEE 294

Query: 899  DAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLL----------QLRTQ 948
              +Q      Q  R+ E  + + +EER+     + + E +R Q L          QLR +
Sbjct: 295  QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354

Query: 949  RPLERLEE---KEVVEFYRDPQLEGSLS-RVKAQVEEEGKRRAGLQADLEVAAQKVVQLE 1004
            +  ER E+   +E  E  R+ QL      R + Q+  E + R   Q   E   ++  QL 
Sbjct: 355  QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 1005 SKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQ------LRGEDAVISARLEGLKK 1058
             +++  +   L +E  +   +   + +  + R++ +Q      L+ E+       E  K+
Sbjct: 415  REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474

Query: 1059 ELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQA 1118
            +L    KR+ + + +    ++ + E+  +  +  Q LR + EE   +R + +E   +LQ 
Sbjct: 475  QL----KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530

Query: 1119 RIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHS 1178
            R+   ++     E +   +++ K E++  L QE    R   E+E  ++  L RE      
Sbjct: 531  RLRSEQQLRREQEER--REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588

Query: 1179 KYSVVEKQRPKVQL------------------------QERVHEIFQVDPETEQEITRLK 1214
            +    +++R + +L                        +ER  ++ + + + E+   +L+
Sbjct: 589  RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648

Query: 1215 AKLQEMAGKRSGVEKEVEKLLPDL-----EVLRAQKPTVEYKEVTQEVVRHERSPEVLRE 1269
             + QE   +R   E+E E+L   L     E  R Q+   E +E  +E ++  R P+   +
Sbjct: 649  REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK-SRIPKWQWQ 707

Query: 1270 IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE 1329
            ++         V S  R QE   R Q + ++ RR  ++++ +         E+    ++E
Sbjct: 708  LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-------EEERAHRQQQE 760

Query: 1330 AERLR--------QEVREAAQKRRAAEDAVYELQSKRLLL-ERRKPEEKVVVQEVVVTQK 1380
             E+ R        +E  E  ++R +A   + E + ++L   ER++ E++ + +E    Q+
Sbjct: 761  EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR 820

Query: 1381 DPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK-----KLAV 1435
              + RE    L    +EE  +RR+   ++Q+   G++E +     QE R       +L  
Sbjct: 821  RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880

Query: 1436 ERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEK--TQVT 1493
            ER+ R+ TL  +      P +QE++  E+ +  E++ +L++     R   +QE+   +  
Sbjct: 881  ERKRRRHTLYAK------PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934

Query: 1494 ELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVL---EDERARVWEMLNRERTAR 1550
            +L +E + L  +    ++ + +E+   K+    QK+  L   E E+ R  E   + R   
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994

Query: 1551 QAREEEARRLRERIDRAETLGRTWSRE---ESELQRARDQADQECGRLQQELRALERQKQ 1607
            + ++EE + LRE  +R +   + W R+   + ELQ+  +Q  +E  R ++ L+  ERQ +
Sbjct: 995  ELQQEEEQLLRE--EREKRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQERERQYR 1051

Query: 1608 QQTLQLQEESKLLSQKTESERQKAAQR----GQELSRLEAAILREKDQ------------ 1651
            ++    QEE +LL ++ E+ R++  +R     +EL + E  +LRE+ +            
Sbjct: 1052 EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111

Query: 1652 -----IYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRG 1706
                   E+E+ LR+   K  R+EL ++ +  E     +  +L  E        E  +R 
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP-------EKRRRQ 1164

Query: 1707 IIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEY 1763
             ++R QY + +EL+ + E++       EE     ++  +QY  E  L+ R+  K+ Y
Sbjct: 1165 ELER-QYREEEELQQEEEQLLR-----EEQEKRRQERERQYREEEELQ-RQKRKQRY 1214



 Score =  143 bits (361), Expect = 1e-33
 Identities = 266/1177 (22%), Positives = 489/1177 (41%), Gaps = 202/1177 (17%)

Query: 638  ERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALK 697
            E+Q +   ++ R  E    Q      E   LQ+R+   Q+ RRE  E      R  + LK
Sbjct: 498  EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE------RREQLLK 551

Query: 698  ASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKN 757
              E     L+   +E  Q L R+Q + R          DQL  RE+  +   L  +Q + 
Sbjct: 552  REEEK--RLEQERRE--QRLKREQEERR----------DQLLKREEERRQQRLKREQEER 597

Query: 758  CKDNLS----SWLEHLPRSQVR-----PSDGPSQIAYKLQAQKRLTQEIQSRERDRATAS 808
             +  L       LE   R + R     P +   Q   K + Q+   Q+   RE+      
Sbjct: 598  LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657

Query: 809  HLSQALQAALQDYELQADTYRCSLEPTLAVSAPK------RPRVAPLQESIQAQ-EKNLA 861
             L +  +    +  L+ +      E  LA    +      + R+   Q  ++++ +   +
Sbjct: 658  RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717

Query: 862  KAYTEVAAAQQQLLQQLEFARKMLEKKELS-------------EDIRRTHDAKQGSESPA 908
            K Y+     + Q  +Q +  ++   + EL              E+ RR    +  +E  +
Sbjct: 718  KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777

Query: 909  QAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQL--RTQRPLERLEEKEVVEFYRDP 966
            + GR+  + +  L E+R+R  R +   + ++  L +   + QR  +R E ++ ++F  + 
Sbjct: 778  ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837

Query: 967  QLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVV--------QLESKRKTMQPHLLTKE 1018
            +      R +   EEE     GLQ D E    +          QLE +RK  +  L  K 
Sbjct: 838  EQLQRRERAQQLQEEED----GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893

Query: 1019 VTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKE 1078
              Q                  +QLR E  ++    E L++E    EKR    +E+   +E
Sbjct: 894  ALQ------------------EQLRKEQQLLQEEEEELQRE--EREKRRRQEQERQYREE 933

Query: 1079 VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKE 1138
                ++  ++++         EE   RR+Q  E   +   +++  E  +   EP+   ++
Sbjct: 934  EQLQQEEEQLLR---------EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984

Query: 1139 V--KKVEQDPGLLQESSRLRSLLEEERTKNATLA-----RELSDLHSKYS-VVEKQRPKV 1190
               KK  ++  L QE  +L   L EER K          R+  +L  +   ++ ++R K 
Sbjct: 985  EREKKYREEEELQQEEEQL---LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041

Query: 1191 QLQERVHEIFQVDPETEQEI---------TRLKAKLQEMAGKRSGVEKEVEKLLPD---- 1237
            +LQER  + ++ + E +QE          TR + +L+    K   +++E E+LL +    
Sbjct: 1042 RLQERERQ-YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100

Query: 1238 ---LEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRL 1294
                E  R  +   E ++  ++++R ER     +E++R   +  E+     + +EQL+R 
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ----QEEEQLLRE 1156

Query: 1295 QGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE----VREAAQKRRAAEDA 1350
            + E+    R R ++E +   +E ++ E++ +L +E E+ RQE     RE  + +R     
Sbjct: 1157 EPEK----RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212

Query: 1351 VYELQSKRLLLERR-KPEEKVVVQEVVVTQK-----------DPKLREEHSR-----LSG 1393
             Y  + +R  L+ + +PE++  V++  V  K           D +LR+  S+     L G
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272

Query: 1394 SL---DEEVGRRR------------QLELEVQQL-----RAGVEEQEGLLSFQEDRSKKL 1433
                 D E  RRR            QLE E Q+      R   EE++ L   +E++ ++ 
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332

Query: 1434 AVERELRQLTLRIQELEKRPPTVQE---KIIMEEVVKLEKDPDLEKSTEALRWDLDQEKT 1490
              +R+ R+    +QE E++P   QE   K   EE+   E+     +  + LR    + K 
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF 1392

Query: 1491 QVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVW------EMLN 1544
               E    C+  + Q+   +  K +E+   +++ R ++DR   +E  +V       + L 
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEE--QQLSRQERDRKFREEEQQVRRQERERKFLE 1450

Query: 1545 RERTARQARE----EEARRLRERIDRA---ETLGRTWSREESELQRA-RDQADQECGRLQ 1596
             E+  RQ R     EE + L+ER ++    +   R +  EE +L+R  RD+  +E     
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510

Query: 1597 QELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQI---- 1652
            QE      +++QQ  + Q + K L ++ +  RQ   +RGQ+  +      RE++Q+    
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ---ERGQQRRQDRDRKFREEEQLRQER 1567

Query: 1653 -------YEKERTLRDLHAKVSREELSQETQTRETNL 1682
                    E++R  R    KV R+E  ++    E  L
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604



 Score =  142 bits (359), Expect = 3e-33
 Identities = 240/1051 (22%), Positives = 450/1051 (42%), Gaps = 87/1051 (8%)

Query: 664  EPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQ 723
            E   LQE   ELQR+ RE   +Q       R  +  E      +   +E  +   RQ+R+
Sbjct: 902  EQQLLQEEEEELQREEREKRRRQ----EQERQYREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 724  VRALTDRY------HAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPS 777
             +   D+         +G++ + R +  Q+    Y++    ++ L    E L R + R  
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRR--QEREKKYRE----EEELQQEEEQLLREE-REK 1010

Query: 778  DGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLA 837
                +   + + +  L QE +   R+      L +  +   ++ ELQ +  +   E    
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070

Query: 838  VSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRT 897
                +  R    +E +Q +E+ L +   E    Q++  Q  E      E+++L   +R  
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL---LREE 1127

Query: 898  HDAKQGSESPAQAGRESEALKAQ---LEEERKRVARVQHELEAQRSQLLQLRTQRPLERL 954
             + ++  E   Q   E E  + +   L EE ++  R + E + +  + LQ   ++ L   
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 955  EEKEVVEFYRDPQLEGSLSRVKA-QVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPH 1013
            +EK   E  R  + E  L R K  Q   +  +R+ L+   E   +  V+     K     
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR---DNKVYCKG 1244

Query: 1014 LLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEK 1073
               ++  Q+E     D Q+ Q    +Q L GE        E  + +       E +  E+
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQ---DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER 1301

Query: 1074 VVVKEVVKVEKNLEMVKAAQALRLQMEEDAARR---KQAEEAVAKLQARIEDLERAISSV 1130
               KE  + ++  +  K  Q LR + EE   R+   ++  E    LQ R E   R     
Sbjct: 1302 EEQKEAKRRDRKSQEEK--QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR-QER 1358

Query: 1131 EPKVIVKEVKKVEQDPGLLQESSRLRS-------LLEEERTKNATLAREL-SDLHSKYSV 1182
            + K   +E++  EQ    L+E  RLR        L EE++ +     ++L  D   K+  
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 1183 VEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEV-- 1240
             E+Q  + +   +  E  Q     E+E   L+ + Q++  +R    +E E+LL + E   
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEE-QQLRQERHRKFREEEQLLQEREEQQ 1477

Query: 1241 LRAQKPTVEYKEVTQEVVRHERS----PEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
            L  Q+   ++ E  Q++ R ER      + LR  +  +  L E    H R Q Q   LQ 
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH-RQQRQRKFLQE 1536

Query: 1297 ERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQS 1356
            E+   R+ER +   +   ++  R E+    E+E ++L ++ R+  +K R  E  V   + 
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKF-REEEQLRQEREEQQLSRQERD--RKFRLEEQKVRRQEQ 1593

Query: 1357 KRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRR---RQLELEVQQLR 1413
            +R  +E  +   +   Q+ +  ++D K RE+   L    ++++ R+   R+   E  QLR
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 1414 AGVEEQEGLLSFQEDRSKKLAVERELRQ----LTLRIQELEKRPPTVQEKIIMEEVVKLE 1469
                EQ+     + DR +K   E +L Q      LR QE +++    ++++  +E     
Sbjct: 1654 RQEREQQ----LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE----R 1705

Query: 1470 KDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKD 1529
            +   L++  +  R +L+++  +  +L +E +  Q++     +   +E+ +  E    Q  
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765

Query: 1530 RVLEDERARVWEMLNRERTARQAREEEA-RRLRERIDRAETLGRTWSREESELQRARDQA 1588
            R   D + R  E L +ER  +Q R +E+ R+ RE     E L     R+E E Q+ R Q 
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREE----EQL-----RQEREEQQLRPQ- 1815

Query: 1589 DQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILRE 1648
             Q  G+ + E   L+ ++Q+Q L+ + + +  +++  + ++K+ +  QEL + E     E
Sbjct: 1816 -QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEE-----E 1869

Query: 1649 KDQIYEKERTLRDLHAKVSREELSQETQTRE 1679
            + +  E+ER LR+ H +  ++E  +  Q  E
Sbjct: 1870 QKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900



 Score =  140 bits (354), Expect = 1e-32
 Identities = 236/1099 (21%), Positives = 484/1099 (44%), Gaps = 122/1099 (11%)

Query: 669  QERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALT 728
            + R  +L+R++ E  EQQ     L R  +         +   +E  +   R+++Q+R   
Sbjct: 333  ERREQQLRREQEERREQQ-----LRREQEEERREQQLRREQEEERREQQLRREQQLRR-- 385

Query: 729  DRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQ 788
                    QL   +++ ++  L  +Q    +  L    +     Q+R      +   K +
Sbjct: 386  ------EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 789  AQKR---LTQEIQSR----ERDRATASHLSQALQAALQ-DYELQADTYRCSLEPTLAVSA 840
             ++R   L +E + R    +R+  T  H  +  +  L+ D E +       LE       
Sbjct: 440  QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 841  PKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDA 900
             +R      +E  + +E+ L K   E    QQ+L  + +  R+  E++E  + ++R  + 
Sbjct: 500  QERREQQLRREQEERREQRL-KRQEEEERLQQRLRSEQQLRREQEERRE--QLLKREEEK 556

Query: 901  KQGSESPAQA-GRESEALKAQL--EEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEK 957
            +   E   Q   RE E  + QL   EE +R  R++ E E +  Q L+      LE+ E +
Sbjct: 557  RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616

Query: 958  EVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTK 1017
            E      +P+ E     +K++ +EE +R+  L+ + +   ++ ++ E + + ++  L  +
Sbjct: 617  EQRLKREEPEEERRQQLLKSEEQEE-RRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675

Query: 1018 EVTQVERDPGLDSQAAQLRIQIQ--------QLRGE-DAVISARLEGLKKELLALEKREV 1068
               +       + +  Q R +I+        QL  E DA  S      +K+     ++E 
Sbjct: 676  HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735

Query: 1069 DVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAAR----RKQAEEAVAKLQARI---- 1120
            + K +       + E  L+  +  +A R Q EE+  R    + QAEE   + + R+    
Sbjct: 736  EEKRR-------RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788

Query: 1121 ---EDLERAISSVE-----PKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARE 1172
               E  ER + + E      + + +E +K ++     +    L+ L EEE+ +    A++
Sbjct: 789  PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAK--LQEMAGKRSGVEKE 1230
            L +        +++R   + +      +Q++ E ++    L AK  LQE   K   + +E
Sbjct: 849  LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908

Query: 1231 VEKLLP--DLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRS- 1287
             E+ L   + E  R Q+   +Y+E  Q     +   ++LRE +R K +  E    + +  
Sbjct: 909  EEEELQREEREKRRRQEQERQYREEEQ---LQQEEEQLLRE-EREKRRRQERERQYRKDK 964

Query: 1288 --QEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRR 1345
              Q++  +L GE  E +R R + E K   +E ++ E++ +L +E E+ R++  E   +++
Sbjct: 965  KLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 1346 AAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQL 1405
                   ELQ +   L R + E++ + +     +++ +L++E  +L G  + E  RR++L
Sbjct: 1024 D------ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGE-ERETRRRQEL 1076

Query: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELR---------QLTLRIQELEKRPPTV 1456
            E + ++     +E+E LL  + ++ ++   ER+ R         +  LR +  ++R   +
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 1457 QEKIIMEEVVKLEKDPDL-EKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ 1515
            + +   EE V+ E++  L E+  +  R +L+++  +  EL +E    Q+  +  +K + +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE--EEQLLREEQEKRRQE 1194

Query: 1516 EKTIYKEVIRVQKDRVL-----EDERARV---WE-----------MLNRERTARQAREEE 1556
             +  Y+E   +Q+ +       ED+R+ +   WE           +  + R   Q R+ E
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254

Query: 1557 ARRLRER---IDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQL 1613
              +LR+R    D    LG    R+  + +R   Q D+     +Q  R  +++ +++  + 
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314

Query: 1614 QEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQ----IYEKERTLRD---LHAKV 1666
            QEE +LL ++ E +R++  Q      R E  +L+E+++      E++R  R+    H + 
Sbjct: 1315 QEEKQLLREEREEKRRR--QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372

Query: 1667 SREELSQETQTRETNLSTK 1685
             R+ L +E + R      K
Sbjct: 1373 GRKFLEEEQRLRRQERERK 1391



 Score =  139 bits (350), Expect = 3e-32
 Identities = 224/996 (22%), Positives = 427/996 (42%), Gaps = 140/996 (14%)

Query: 786  KLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPR 845
            K + +KRL QE + +   R       Q L+   ++ E +    +   E  L     KR  
Sbjct: 551  KREEEKRLEQERREQRLKREQEERRDQLLK---REEERRQQRLKREQEERLEQRL-KREE 606

Query: 846  VAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSE 905
            V  L++  + +E+ L +   E    +QQLL+  E   +  ++    +  RR    K+  E
Sbjct: 607  VERLEQE-ERREQRLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 906  SPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQL--RTQRPLERLEEKEVVEFY 963
                  R  + LK + EEER+     + E E  R ++     + Q  LE   +    + Y
Sbjct: 665  EE----RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720

Query: 964  RDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQ-- 1021
              P+ +    R + Q E+  +R + LQ   E  A +  Q E +R+        +E ++  
Sbjct: 721  SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780

Query: 1022 ----VERDPGLDSQAAQLRIQIQQLRG--------EDAVISARLEGLKKELLALEKREVD 1069
                  R P  + +  QLR + +Q R         E      +    +KEL  LE+ E  
Sbjct: 781  RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE-Q 839

Query: 1070 VKEKVVVKEVVKVEKNLEM---------VKAAQALRLQMEEDAARRKQAEEAVAKLQARI 1120
            ++ +   +++ + E  L+           +  Q  R Q+EE+  RR+    A   LQ ++
Sbjct: 840  LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899

Query: 1121 EDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKY 1180
               ++ +   E     +E+++ E++    QE  R     E+ + +   L RE  +   + 
Sbjct: 900  RKEQQLLQEEE-----EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954

Query: 1181 SVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLL-PDLE 1239
                + R   +LQ++  ++   +PE  +   R K   +E       +++E E+LL  + E
Sbjct: 955  ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE-----EELQQEEEQLLREERE 1009

Query: 1240 VLRAQKPTVEYK---EVTQE---VVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIR 1293
              R Q+   +Y+   E+ QE   ++R ER    L+E +R   +  EL     + +EQL+ 
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ----QEEEQLL- 1064

Query: 1294 LQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYE 1353
              GE  E RR R ++E +   +E ++ E++ +L +E E+ R++ RE    R+  E+   +
Sbjct: 1065 --GEERETRR-RQELERQYRKEEELQQEEEQLLREEPEKRRRQERE----RQCREEEELQ 1117

Query: 1354 LQSKRLLLERR------------KPEEKVVVQEVVVTQKDPK------------------ 1383
             + ++LL E R            + EE+V  +E  + +++P+                  
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177

Query: 1384 ------LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVE- 1436
                  LREE  +     + +     +L+ + ++ R   E+Q   L +Q +  K+ AV  
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237

Query: 1437 -------RELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDL-DQE 1488
                   RE  Q   ++++ + R    Q+ +  + ++  +++ D E+  E  RW   D+ 
Sbjct: 1238 NKVYCKGRENEQFR-QLEDSQLRDRQSQQDL--QHLLGEQQERDREQ--ERRRWQQRDRH 1292

Query: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERT 1548
              +  +L RE +    + D   +   +EK + +E    ++ R   D + R  E L +ER 
Sbjct: 1293 FPEEEQLEREEQKEAKRRD---RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 1549 ARQAREEEA-RRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQ 1607
             +  R +E  R+ RE   R +  GR +  EE  L+R   + +++  + +Q+LR  ER++Q
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR--QERERKFLKEEQQLRCQEREQQ 1407

Query: 1608 ------------QQTLQLQEESKLLSQKTESERQKAAQRG-----QELSRLEAAILREKD 1650
                        +Q L  QE  +   ++ +  R++  +R      Q+L +      RE++
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 1651 QIYEKERTLRDLHAKV-SREELSQETQTRETNLSTK 1685
            Q+ + ER  + LH +   R+ L +E Q R      K
Sbjct: 1468 QLLQ-EREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502



 Score =  138 bits (348), Expect = 5e-32
 Identities = 364/1783 (20%), Positives = 718/1783 (40%), Gaps = 254/1783 (14%)

Query: 55   RDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEE 114
            R+  + Q+R +QDR+  E+ +    ++ET    KE E L ++   +  + R L+  + + 
Sbjct: 223  REEKQQQRRERQDRVFQEEEEKEWRKRETVLR-KEEEKLQEE---EPQRQRELQEEEEQL 278

Query: 115  IEKDIKQLH-ERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMA 173
             + + ++L  ER  +E  + R   E+ +       R +      ++Q++           
Sbjct: 279  RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER----------R 328

Query: 174  ELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQ 233
            E +++  E  + +++ +   QQLR     +    R Q     +    R Q L       Q
Sbjct: 329  EQQEERREQQLRREQEERREQQLRREQEEER---REQQLRREQEEERREQQL----RREQ 381

Query: 234  GCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERM 293
               R+     EQQ R  QQ           +RRE +  ++ + L +EQ + + +      
Sbjct: 382  QLRREQQLRREQQLRREQQ-----------LRRE-QQLRREQQLRREQQLRREQQLRREQ 429

Query: 294  VELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLN 353
             E RH      +  ++ LK E +   +    +E   +H ++ R+ Q + D   +   +  
Sbjct: 430  EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW- 488

Query: 354  SNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQ 413
              L+ +             E  +Q E  E++L   +    + + + ++     Q+R   +
Sbjct: 489  LKLEEE-------------ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535

Query: 414  QPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPD 473
            Q L  +     +    QLL+ E  K ++       + +    E +R             D
Sbjct: 536  QQLRREQ----EERREQLLKREEEKRLEQERREQRLKREQ--EERR-------------D 576

Query: 474  AVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQA---QKLLTQ 530
             + +      + +  +++   ++ RLK   VE L   ++         P+    Q+LL  
Sbjct: 577  QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636

Query: 531  MTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKEC 590
              + +    Q+ R+        L R    E LE R+       +R Q L  E+   Q++ 
Sbjct: 637  EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE---QEQA 693

Query: 591  EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRG 650
               + +R +     QL    ++ ++K         +Y    K      RQ Q+  R  R 
Sbjct: 694  RERIKSR-IPKWQWQLESEADARQSK---------VYSRPRKQEGQRRRQEQEEKRRRRE 743

Query: 651  FEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNF 710
             E    +E            R  + + QRR+   Q     +  R  +    A   L+   
Sbjct: 744  SELQWQEEERA--------HRQQQEEEQRRDFTWQWQAEEKSERGRQRLS-ARPPLREQR 794

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
            +   +   RQQR+ R L +       +   RE+                +    +LE   
Sbjct: 795  ERQLRAEERQQREQRFLPEEEEKEQRRRQRRER----------------EKELQFLEEEE 838

Query: 771  RSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRC 830
            + Q R      + A +LQ ++   QE Q R R +          Q   Q +  Q +  R 
Sbjct: 839  QLQRR------ERAQQLQEEEDGLQEDQERRRSQE---------QRRDQKWRWQLEEERK 883

Query: 831  SLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKEL 890
                TL      + ++   Q+ +Q +E+ L +   E    Q+Q  Q  E  +   E+++L
Sbjct: 884  RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943

Query: 891  ----SEDIRRTHDAKQGSESPAQAGRESEALKAQLE----EERKRVARVQHELEAQRSQL 942
                 E  RR    +Q  +      +E + L  + E    +ER++  R + EL+ +  QL
Sbjct: 944  LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003

Query: 943  LQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQV-EEEGKRRAGLQADLEVAAQKVV 1001
            L+       E  E++   E+ R  + +  L + + Q+  EE ++R   + + +   ++ +
Sbjct: 1004 LR-------EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 1002 QLESKRKTMQPHLLTKEVTQVERDPGLDSQ---AAQLRIQIQQLRGEDAVISARLEGLKK 1058
            Q E ++       L  E  +  R   L+ Q     +L+ + +QL  E+     R E   +
Sbjct: 1057 QQEEEQ-------LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE---R 1106

Query: 1059 ELLALEKREVDVKEKVVVKEVVKVEKNLEMVKA-AQALRLQMEEDAARRKQAEEAVAKLQ 1117
            E    E+ E+  +E+ +++E  +  +  E+ +   +   +Q EE+   R++ E+   +  
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166

Query: 1118 ARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLH 1177
             R    E  +   E +++ +E +K  Q+        R R   EEE  +     +   D  
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQE--------RERQYREEEELQRQKRKQRYRDED 1218

Query: 1178 SKYSVVEKQRPKVQLQERVHEIFQVDPETEQ----EITRLKAK-----LQEMAGKRSGVE 1228
             +  +  +  P+ +   R ++++    E EQ    E ++L+ +     LQ + G++   +
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278

Query: 1229 KEVEKL--------LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNEL 1280
            +E E+          P+ E L  +    E KE  +   + +   ++LRE +R + +  + 
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLERE----EQKEAKRRDRKSQEEKQLLRE-EREEKRRRQE 1333

Query: 1281 VNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREA 1340
             +   R +EQL++   ER+E    R + + K   +E+   E+     +E +RLR++ RE 
Sbjct: 1334 TDRKFREEEQLLQ---EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390

Query: 1341 A----QKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGS-- 1394
                 +++   ++   +L+  R   +R+  EE+   Q++   ++D K REE  ++     
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDR---DRKFREEE---QQLSRQERDRKFREEEQQVRRQER 1444

Query: 1395 ----LDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVE-----RELRQLTLR 1445
                L+EE   R++   + ++    ++E+E     +++R +K   E     R+ R    R
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504

Query: 1446 IQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQ 1505
             QEL  + P   E+  +EE  +L +     K  +  +    QE+ Q    +R+ K  + +
Sbjct: 1505 EQELRSQEP---ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561

Query: 1506 IDVLQKAKSQEKTIYKEVIRVQKDRV--LEDERARVWEMLNR--ERTARQAREEEARRLR 1561
                Q  + +E+   +++ R ++DR   LE+++ R  E   +  E   +  R+E  ++LR
Sbjct: 1562 ----QLRQEREE---QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614

Query: 1562 ERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQ------------QQ 1609
            +  DR         +E  E Q  R + D++    + +LR  ER++Q            +Q
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674

Query: 1610 TLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLR-DLHAKVSR 1668
             LQ  EE +L  Q+ +   +K  +  Q+L R E    RE+  + E+++  R +L  K   
Sbjct: 1675 LLQEGEEQQLRRQERD---RKFREEEQQLRRQE----RERKFLQEEQQLRRQELERKFRE 1727

Query: 1669 EE-LSQETQTRETNLSTKI-SILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEV 1726
            EE L QET+  +     +   ILE E    + P            Q L+ QE +  + E 
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEE---QLRPER--------EEQQLRRQERDRKFREE 1776

Query: 1727 TTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDG 1769
                   EE  L  ++S +++  E  LR  R  ++     +DG
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819



 Score =  128 bits (321), Expect = 6e-29
 Identities = 192/831 (23%), Positives = 374/831 (45%), Gaps = 89/831 (10%)

Query: 911  GRESEALKAQLEEERKRVARVQHELE---AQRSQLLQLRTQRPL----ERLEEKEVVEFY 963
            G+ES     + EE+++R      +LE    QR +  +   +R L    E+ E++E +E  
Sbjct: 105  GKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQR 164

Query: 964  RDPQLEGSLSRVKAQVEEEGKRRA---GLQA-----------DLEVAAQKVVQLESK--- 1006
               + +  L R + + +E  +RRA    LQ+           + ++  +++++L  K   
Sbjct: 165  DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224

Query: 1007 RKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKR 1066
             K  Q       V Q E +     +   LR + ++L+ E+      L+  +++L  LE++
Sbjct: 225  EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284

Query: 1067 EVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERA 1126
            E+        +E  + E+  + ++  Q LR + EE+  RR+Q EE   + + R +  ER 
Sbjct: 285  ELR-------RERQEEEQQQQRLRREQQLRRKQEEE--RREQQEERREQQERREQQEERR 335

Query: 1127 ISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQ 1186
               +  +   +  +++ ++    +   +LR   EEER +   L RE   L  +  +  +Q
Sbjct: 336  EQQLRREQEERREQQLRREQEEERREQQLRREQEEER-REQQLRRE-QQLRREQQLRREQ 393

Query: 1187 RPKVQLQERVHEIFQVDPE--TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQ 1244
            + + + Q R  +  + + +   EQ++ R +   +E   +R   + E E+   +  + R Q
Sbjct: 394  QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER--REQRLKREQ 451

Query: 1245 KPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRE 1304
            +   ++ +  +E  RHE+        +R K QL    +     +E+ ++L+ E    ++E
Sbjct: 452  EERRDWLKREEETERHEQ--------ERRKQQLKR--DQEEERRERWLKLEEEERREQQE 501

Query: 1305 RAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYEL----QSKRLL 1360
            R + + +   +E  R E+    ++E ERL+Q +R   Q RR  E+   +L    + KRL 
Sbjct: 502  RREQQLRREQEE--RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559

Query: 1361 LERR----KPEEKVVVQEVVVTQKDPK----LREEHSRLSGSLD-EEVGRRRQLELEVQQ 1411
             ERR    K E++    +++  +++ +     RE+  RL   L  EEV R  Q E   Q+
Sbjct: 560  QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619

Query: 1412 LRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKD 1471
            L+    E+E     +  +  K   + E RQ  LR ++ E+R   ++ +   EE  +LE+ 
Sbjct: 620  LKREEPEEE-----RRQQLLKSEEQEERRQQQLRREQQERREQRLKRE---EEEERLEQR 671

Query: 1472 PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRV 1531
               E   E    +L +E+ +      + +  + Q  +  +A +++  +Y    + +  R 
Sbjct: 672  LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR- 730

Query: 1532 LEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTW---SREESELQRARDQA 1588
                R +  E   R R +    +EE R  R++ +  +    TW   + E+SE  R R  A
Sbjct: 731  ----RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786

Query: 1589 DQEC-GRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQ---RGQELSRLEAA 1644
                  + +++LRA ERQ+++Q    +EE K   ++   ER+K  Q     ++L R E A
Sbjct: 787  RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846

Query: 1645 --ILREKDQIYEKERTLRDLHAKVS---REELSQETQTRETNLSTKISILE 1690
              +  E+D + E +   R    +     R +L +E + R   L  K ++ E
Sbjct: 847  QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897



 Score =  124 bits (312), Expect = 7e-28
 Identities = 158/655 (24%), Positives = 298/655 (45%), Gaps = 74/655 (11%)

Query: 1041 QLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQME 1100
            Q  G D    AR +G  KE L  ++R+ + + +   ++     + LE  +  Q  R + +
Sbjct: 91   QATGLDEEKRARCDG--KESLLQDRRQEEDQRRFEPRD-----RQLEE-EPGQRRRQKRQ 142

Query: 1101 EDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSL-- 1158
            E      + EE   K Q R+E  +R     E   + ++ ++ ++      E  +L+S   
Sbjct: 143  EQERELAEGEEQSEK-QERLEQRDRQRRDEE---LWRQRQEWQEREERRAEEEQLQSCKG 198

Query: 1159 --LEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQE-----IT 1211
               EE   +     REL +L  K     ++  + Q +ER   +FQ + E E       + 
Sbjct: 199  HETEEFPDEEQLRRRELLELRRK----GREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254

Query: 1212 RLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREID 1271
            + + KLQE   +R    +E E+ L  LE               QE+ R  +  E  ++  
Sbjct: 255  KEEEKLQEEEPQRQRELQEEEEQLRKLE--------------RQELRRERQEEEQQQQRL 300

Query: 1272 RLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAE 1331
            R + QL        R Q++  R Q ER E + ER + + +   +E  R E+    E+E E
Sbjct: 301  RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE--RREQQLRREQEEE 358

Query: 1332 RLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRL 1391
            R  Q++R   ++ R  +    E Q +R   E++   E+ + +E  + ++    RE+  R 
Sbjct: 359  RREQQLRREQEEERREQQLRREQQLRR---EQQLRREQQLRREQQLRREQQLRREQQLRR 415

Query: 1392 SGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSK---KLAVERELRQLTLRIQE 1448
               L  E   RR+ E E  + +   E +E  L  +++  +   K   E E  +   R Q+
Sbjct: 416  EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475

Query: 1449 LEKRPPTVQEKIIMEEVVKLEKDP---DLEKSTEALRWDLDQEKTQVTELNRECKNLQVQ 1505
            L++     QE+   E  +KLE++      E+  + LR + ++ + Q  +   E + LQ +
Sbjct: 476  LKRD----QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531

Query: 1506 IDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQ----AREEEARRLR 1561
            +   Q+ + +++   +++++ ++++ LE ER    + L RE+  R+     REEE R+ R
Sbjct: 532  LRSEQQLRREQEERREQLLKREEEKRLEQERRE--QRLKREQEERRDQLLKREEERRQQR 589

Query: 1562 ERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLS 1621
             + ++ E L +   REE E             RL+QE R  +R K+++  + + +  L S
Sbjct: 590  LKREQEERLEQRLKREEVE-------------RLEQEERREQRLKREEPEEERRQQLLKS 636

Query: 1622 QKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQ 1676
            ++ E  RQ+  +R Q+  R E  + RE+++   ++R  R+   +   +EL++E Q
Sbjct: 637  EEQEERRQQQLRREQQ-ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690



 Score =  103 bits (258), Expect = 1e-21
 Identities = 135/590 (22%), Positives = 259/590 (43%), Gaps = 37/590 (6%)

Query: 1149 LQESSRLR-----SLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVD 1203
            L E  R R     SLL++ R +      E  D   +    +++R K Q QER  E+ + +
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER--ELAEGE 152

Query: 1204 PETEQEIT---RLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRH 1260
             ++E++     R + +  E   ++    +E E+   + E L++ K     +   +E +R 
Sbjct: 153  EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 1261 ERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH 1320
                   RE+  L+ +  E      R ++  +  + E  EWR+    +  +    +    
Sbjct: 213  -------RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 1321 EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQK 1380
            ++   L++E E+LR+  R+  ++ R  E+   +   +   L R++ EE+   QE    Q+
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 1381 DPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQ---EGLLSFQED--RSKKLAV 1435
            + + ++E  R      E+  RR Q E   QQLR   EE+   + L   QE+  R ++L  
Sbjct: 326  ERREQQEERR------EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379

Query: 1436 ERELR--QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVT 1493
            E++LR  Q   R Q+L +     +E+ +  E  +L ++  L +  +  R   ++   Q  
Sbjct: 380  EQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQEEERHEQKH 438

Query: 1494 ELNRECKNLQVQIDVLQK-AKSQEKTIYKEVIR--VQKDRVLEDERARVWEMLNRERTAR 1550
            E  R  + L+ + +  +   K +E+T   E  R   Q  R  E+ER   W  L  E    
Sbjct: 439  EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 1551 QAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT 1610
            Q    E +  RE+ +R E   R   +EE E  + R +++Q+  R Q+E R  +  K+++ 
Sbjct: 499  QQERREQQLRREQEERREQ--RLKRQEEEERLQQRLRSEQQLRREQEERRE-QLLKREEE 555

Query: 1611 LQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREE 1670
             +L++E +    K E E ++     +E  R +  + RE+++  E+     ++      E 
Sbjct: 556  KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 1671 LSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELE 1720
              Q  +  E     +  +L+ E  ++    +  +     R Q L+ +E E
Sbjct: 616  REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665



 Score = 40.0 bits (92), Expect = 0.023
 Identities = 88/421 (20%), Positives = 160/421 (38%), Gaps = 54/421 (12%)

Query: 47   QANADQVERDILETQKRLQQDRLNS--EQSQALQ-------HQQETGRSLKEAEVLLKDL 97
            Q    + ER  LE +++L+Q+R     E+ Q LQ       H+QE  R   E E  L+  
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497

Query: 98   FLDV---DKARRLKHPQAEEIEKDIKQLHE-----RVTQECAEYRALYEKMVLPPDVGPR 149
              D    ++  R + P+ + +E++ +QLH      +  QE  + R          D   +
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEE-QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556

Query: 150  V-DWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIR 208
              +  ++ +++++Q  + Q       LE+Q       +++     QQLR   G       
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR-- 1614

Query: 209  SQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREY 268
             Q RD                   +   + L    EQQ    ++D   L  +P   R+E 
Sbjct: 1615 -QERD----------------RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657

Query: 269  EHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQ 328
            E   +H+   + +   QL  +GE     R       +  ++ L+ + +      + +E Q
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE--RKFLQEEQQ 1715

Query: 329  LQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVT 388
            L+  E  R+F+EE + + Q   +       +Y          P    QQL  +E+     
Sbjct: 1716 LRRQELERKFREE-EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774

Query: 389  ER------------ATGDLQRRSRDVAPLPQRRNPPQ-QPLHVDSICDWDSGEVQLLQGE 435
            E              + +  R+ R+   L Q R   Q +P   D    W+  ++QL + E
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834

Query: 436  R 436
            +
Sbjct: 1835 Q 1835



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 87/396 (21%), Positives = 151/396 (38%), Gaps = 51/396 (12%)

Query: 37   QELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKD 96
            +E  L   R +    ++ER   E ++  Q++     +    + +QE  R  +E E L ++
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179

Query: 97   LFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAE-YRALYEKMVLPPDVGPRVDWARV 155
               +    R  +  + +E E+  ++  E   Q+  + YR   ++  L     P  + A  
Sbjct: 1180 ---EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA-- 1234

Query: 156  LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLL 215
              +  K  C G+      +LE         Q       Q L+ L+G      R Q R   
Sbjct: 1235 -VRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-------QDLQHLLGEQQERDREQERR-- 1284

Query: 216  KAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYE---HFK 272
                 R Q     +   +   R+    A+++ R  Q++   L  +    RR  E    F+
Sbjct: 1285 -----RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339

Query: 273  QHELLSQEQSVNQL----EDDGERMVELRHPAVGP--IQAHQEALKMEWQ-NFL---NLC 322
            + E L QE+    L     D   R  ELRH   G   ++  Q   + E +  FL      
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399

Query: 323  ICQETQLQHVEDY-RRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE 381
             CQE + Q  +D  R+F+EE   +S+         D K+            + +++ E E
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSR------QERDRKFR--------EEEQQVRRQERE 1445

Query: 382  EKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLH 417
             K L   ++   +  R+ R+   L Q R   +Q LH
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQERE--EQQLH 1479



 Score = 31.6 bits (70), Expect = 8.3
 Identities = 72/329 (21%), Positives = 131/329 (39%), Gaps = 45/329 (13%)

Query: 28  PSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETG--- 84
           P +  R   QE    ++  +  +++ ER  LE + R ++D     Q Q  Q ++E     
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQER--LEQRDRQRRDEELWRQRQEWQEREERRAEE 190

Query: 85  RSLKEAEVLLKDLFLDVDKARR-----LKHPQAEEIEKDIKQLHERVTQECAEYRALYEK 139
             L+  +    + F D ++ RR     L+    EE ++  ++  +RV QE  E      +
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250

Query: 140 MVLPPDVGPRVDWA----RVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQ 195
            VL  +     +      R L+++++Q+   +      E +++  +   L++E     QQ
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE-----QQ 305

Query: 196 LRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWS 255
           LR     +    R Q  +  +    R Q         Q   R+     EQ+ R  QQ   
Sbjct: 306 LRRKQEEER---REQQEERREQQERREQ---------QEERREQQLRREQEERREQQ--- 350

Query: 256 DLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQ---AHQEALK 312
                   +RRE E  ++ + L +EQ   + E    R  +LR       +     ++ L+
Sbjct: 351 --------LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402

Query: 313 MEWQNFLNLCICQETQLQHVEDYRRFQEE 341
            E Q      + +E QL+  +  RR QEE
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEE 431


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  157 bits (397), Expect = 1e-37
 Identities = 332/1532 (21%), Positives = 634/1532 (41%), Gaps = 195/1532 (12%)

Query: 242  LAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAV 301
            LAE ++ + ++D        A +    +   +  LL+++Q+ + LE   + + ELR    
Sbjct: 237  LAENRKLLTEKD--------AQIAMMQQRIDRLALLNEKQAASPLEP--KELEELRDK-- 284

Query: 302  GPIQAHQEALKMEWQNFLNLCICQETQLQHVE-DYRRFQEEADSVSQTLAKLNSNLDA-- 358
                   E+L M     L  C   +T+   ++    +  EE   +S  L +  S+L    
Sbjct: 285  ------NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338

Query: 359  -KYSPAPGGPPGAPTELLQQLEAEEKRLAVT-----------ERATGDLQRRSRDVAPLP 406
               +        A  E L++    EK L+             E   G L +    ++ L 
Sbjct: 339  DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398

Query: 407  QRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLV-DNTDPHAWVVQGPGGETKRAPAACF 465
               NPPQ+   V      D  +++ L+ E   L  +NT   A V      ET+R      
Sbjct: 399  D--NPPQEKGEVLG----DVLQLETLKQEAATLAANNTQLQARVEML---ETERGQQ--- 446

Query: 466  CIPAPDPDAVARASRLASELQALKQKLATVQSRLK--ASAVESLRPSQQAPSGSDLANPQ 523
                 +   +A       E Q L   +  +QS +   + A E L  + QA      A  Q
Sbjct: 447  -----EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA--Q 499

Query: 524  AQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPL-EDLEGRIHSHEGTAQRLQSLGT- 581
               L +++T L+  + Q ++++    +    +   L + L+ +  + +G   +++ L + 
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 582  --EKETAQKE-CEAFLSTRPVGPAALQLPVALN----SVKNKFSDVQVLCSLYGEKAKAA 634
              +KE   KE  E   +TR     A QL  A      S++ + + ++ L +L  EKA   
Sbjct: 560  LKQKEQQLKEVAEKQEATRQ--DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617

Query: 635  LDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQR----QRRELLEQQTCVL 690
              L++Q+Q A+      + ++ Q     AE   L  +V ELQ      R+E  E Q  V 
Sbjct: 618  EILQQQLQVANEARDSAQTSVTQAQREKAE---LSRKVEELQACVETARQEQHEAQAQVA 674

Query: 691  RLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAAL 750
             L   L++ +      +   QE  Q     Q Q++AL +        L+  ++   DA  
Sbjct: 675  ELELQLRSEQQKATEKERVAQEKDQ----LQEQLQALKESLKVTKGSLEEEKRRAADALE 730

Query: 751  TYQQ-FKNCKDNLSSWLEHLPRSQVRPSD---GPSQIAYKLQ----AQKRLTQEIQSRER 802
              Q+     K    S +E   R +    +   G   +  +LQ    A +  T+ ++    
Sbjct: 731  EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA 790

Query: 803  DRATASHLSQA-LQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLA 861
            +   A H +++  +  +++     + Y  S +      A  + ++  L+E  +   + L 
Sbjct: 791  EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850

Query: 862  KAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQA-GRESEALKAQ 920
            +A  +VA  +     +L+ +R+  E  EL  ++ R     Q  E  AQ    +   L+ +
Sbjct: 851  EAKEKVAGIESH--SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908

Query: 921  LEEERKRVARVQ-------HELEAQRSQLLQLRTQ---RPLERLEEKEVVEFYRDPQLEG 970
            +    K VAR++        + E    +L++   +   R  E LEE++  +F      + 
Sbjct: 909  MAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC---STQA 965

Query: 971  SLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDS 1030
            +L  ++ + E+ G     L+A L + +Q   Q E  ++  +   LT+E  + + D  L+ 
Sbjct: 966  ALQAMEREAEQMGNELERLRAAL-MESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024

Query: 1031 QA-AQLRIQIQQLRGEDAVISARL-----------EGLKKELLALEKREV-DVKE----- 1072
             A A+L +++Q    E  V  A L           EG  +EL  L   E   +KE     
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 1073 ---KVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA-VAKLQARIEDLERAIS 1128
               K + +++ K EK       AQ+      E    + +A  A V+KL+ + +  +    
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 1129 SVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRP 1188
            S+E  +  +   + E+D  L      L+  LEE+       A+EL   HS+ ++   QR 
Sbjct: 1145 SLERSLEAERASRAERDSAL----ETLQGQLEEK-------AQELG--HSQSALASAQRE 1191

Query: 1189 KVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTV 1248
                + +V +  + + E + ++ R + + +      S +E+EV  L  + +VL  +    
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL--NRQVLEKEG--- 1246

Query: 1249 EYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV 1308
            E KE+ + V+      + L E  RL+    E  ++  R+ E+   L   R+E +  R + 
Sbjct: 1247 ESKELKRLVMAESEKSQKLEE--RLRLLQAETASNSARAAERSSAL---REEVQSLREEA 1301

Query: 1309 ETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQ----SKRLLLERR 1364
            E + V+ E +R E     E+ AE L QE++   +K    E A+  LQ    S + L+   
Sbjct: 1302 EKQRVASENLRQELTSQAER-AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360

Query: 1365 KPE----EKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQE 1420
             P     +++  ++    ++  +  E+  + +G L  E+ R ++   E+  LR  V EQE
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420

Query: 1421 GLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIM-EEVVKLEKDPDLEKSTE 1479
               + Q+ R++K +   +L  L      L +    + E+  +  + +++E D   EK  +
Sbjct: 1421 R--TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQ 1478

Query: 1480 ALRWDLDQEKTQVTELNRECKNLQVQIDVLQ-KAKSQEKTIYKEVIRVQKDRVLEDERAR 1538
             L       +T++ E+ RE ++   +++V+  K +  +  + +E  R Q++R     +  
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538

Query: 1539 VWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQE 1598
              E+  RE+T      ++   L +++  ++   +   ++   +Q    ++ QE  RLQ +
Sbjct: 1539 QLEVFQREQT------KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592

Query: 1599 LRALERQ------------------------KQQQTLQLQEESKLLSQKTESERQKAAQR 1634
            L  L+ Q                        K+QQ  +LQE+ + L Q  +  ++  A+ 
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652

Query: 1635 GQELSRLEAAILREKDQIYEKERTLRDLHAKV 1666
             +    L+ A L+ K    E E+T R L A+V
Sbjct: 1653 ERLGHELQQAGLKTK----EAEQTCRHLTAQV 1680



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 121/612 (19%), Positives = 257/612 (41%), Gaps = 91/612 (14%)

Query: 1095 LRLQMEEDAARRKQAEEAVAKLQARIEDL-----ERAISSVEPKVIVKEVKKVEQDPGLL 1149
            L L++ E+     + +  +A +Q RI+ L     ++A S +EPK + +   K E     L
Sbjct: 233  LELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRL 292

Query: 1150 QESSRLRSLLEEERTKNATLARELSDLHS--KYSVVEKQRPKVQLQERVHEIFQVDPETE 1207
             E+ +    L+ E+++      +LS+ +    + + E      QLQ+ ++E+ +   +  
Sbjct: 293  HETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352

Query: 1208 QEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYK--EVTQEVVRHERSP- 1264
            QE    +A+L          EKE+   L D + L  +   ++ K  ++ + + + + +P 
Sbjct: 353  QEWLEKQAQL----------EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402

Query: 1265 ----EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH 1320
                EVL ++ +L+    E       + +    LQ   +    ER + E K +++     
Sbjct: 403  QEKGEVLGDVLQLETLKQEAATLAANNTQ----LQARVEMLETERGQQEAKLLAERGHFE 458

Query: 1321 EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQK 1380
            E+   L      L+  +   +Q +   E A  +    RL  +      ++      + Q+
Sbjct: 459  EEKQQLSSLITDLQSSISNLSQAKEELEQAS-QAHGARLTAQVASLTSELTTLNATIQQQ 517

Query: 1381 DPKL-------REEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLL--------SF 1425
            D +L       +E+ ++L+ +L ++    + L  +V+QL + ++++E  L        + 
Sbjct: 518  DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577

Query: 1426 QEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDL 1485
            ++D +++LA   E R+ +LR ++   +     EK   E+  KLE    L++  +      
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEK---EKAAKLEI---LQQQLQVANEAR 631

Query: 1486 DQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNR 1545
            D  +T VT+  RE   L  +++ LQ                                   
Sbjct: 632  DSAQTSVTQAQREKAELSRKVEELQACVE------------------------------- 660

Query: 1546 ERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQ 1605
              TARQ + E   ++ E     E   R+  ++ +E +R   + DQ    LQ++L+AL+  
Sbjct: 661  --TARQEQHEAQAQVAE----LELQLRSEQQKATEKERVAQEKDQ----LQEQLQALKES 710

Query: 1606 KQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAK 1665
             +     L+EE +  +   E +++  ++   E   L     RE+ ++ E+    + L A+
Sbjct: 711  LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770

Query: 1666 VSREELSQETQT 1677
            + +   + + +T
Sbjct: 771  LQQLGEAHQAET 782



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 114/583 (19%), Positives = 242/583 (41%), Gaps = 93/583 (15%)

Query: 1154 RLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRL 1213
            RL+  L +ER+    L  EL++  ++  + EK      +Q+R+  +  ++ +  Q  + L
Sbjct: 218  RLKKQLADERSNRDELELELAE--NRKLLTEKDAQIAMMQQRIDRLALLNEK--QAASPL 273

Query: 1214 KAK-LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLRE--- 1269
            + K L+E+  K   +   + + L   + L+ +K  ++ K + Q    +      LRE   
Sbjct: 274  EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK-INQLSEENGDLSFKLREFAS 332

Query: 1270 -IDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEK 1328
             + +L+  LNEL   H ++ +          EW  ++A+                  LEK
Sbjct: 333  HLQQLQDALNELTEEHSKATQ----------EWLEKQAQ------------------LEK 364

Query: 1329 EAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEH 1388
            E     Q+ +   +K    +  + +L+     L+   P+EK  V   V+  +   L++E 
Sbjct: 365  ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLET--LKQEA 422

Query: 1389 SRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQE 1448
            + L+ +  +   R   LE E  Q  A +  + G   F+E++ +  ++  +L+     I  
Sbjct: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERG--HFEEEKQQLSSLITDLQS---SISN 477

Query: 1449 LEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQI-D 1507
            L +    +++           +   L      L   + Q+  ++  L ++ K  Q Q+  
Sbjct: 478  LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537

Query: 1508 VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRA 1567
             LQ+ +   + +  +V ++     L+ +  ++ E+  ++   RQ             D A
Sbjct: 538  TLQQQEQASQGLRHQVEQLSSS--LKQKEQQLKEVAEKQEATRQ-------------DHA 582

Query: 1568 ETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQ------QQTLQLQEESKLLS 1621
            + L       E+ L R RD A        ++L ALE++K       QQ LQ+  E++  +
Sbjct: 583  QQLATAAEEREASL-RERDAA-------LKQLEALEKEKAAKLEILQQQLQVANEARDSA 634

Query: 1622 QK--TESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKV------------- 1666
            Q   T+++R+K A+  +++  L+A +   + + +E +  + +L  ++             
Sbjct: 635  QTSVTQAQREK-AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERV 693

Query: 1667 --SREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGI 1707
               +++L ++ Q  + +L      LE E  +     E  +R I
Sbjct: 694  AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 39/170 (22%), Positives = 74/170 (43%), Gaps = 39/170 (22%)

Query: 43   ISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGR----------SLKEAEV 92
            +S+  A++DQ  +        +QQ +L + Q+Q  + QQE  R           L + E 
Sbjct: 1554 LSKKLADSDQASK--------VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605

Query: 93   LLKDLFLDVDKARR---LKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVGPR 149
              +   L ++KA+     K  Q +E+++ ++ L E++ +E  E RA  E++      G  
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL-EQLQKENKELRAEAERL------GHE 1658

Query: 150  VDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSL 199
            +  A +  ++ +Q C               A+   L+ ++    QQLR L
Sbjct: 1659 LQQAGLKTKEAEQTC-----------RHLTAQVRSLEAQVAHADQQLRDL 1697


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  156 bits (394), Expect = 2e-37
 Identities = 209/960 (21%), Positives = 428/960 (44%), Gaps = 134/960 (13%)

Query: 832  LEPTLAVSAPKRPRVAPLQESIQAQEKNLA--KAYTEVAAAQQQLL-QQLEFARKMLEKK 888
            ++P L VS  +   +A  +E ++ +EK LA     TE+   Q QL+ ++L+   ++  + 
Sbjct: 834  VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893

Query: 889  EL---SEDIRRTHDAKQGS------ESPAQAGRESEA---LKAQLEEERKRVARVQHELE 936
            EL   +E++R    AK+        +  A+   E E    L+A+ ++ ++ +  ++ +LE
Sbjct: 894  ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953

Query: 937  AQRS-----QLLQLRTQRPLERLEEKEVV--------------------EFYRD------ 965
             + S     QL ++ T+  L++LEE++++                    EF  +      
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 966  ----------------PQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKT 1009
                              LE  L R + Q +E  K R  L+ D    + ++ +L+++   
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073

Query: 1010 MQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVD 1069
            ++  L  KE         ++ +AAQ  + ++++R  ++ IS   E L+ E  +  K E  
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133

Query: 1070 VKEKVVVKEVVK--VEKNLEMVKAAQALRLQMEEDA-ARRKQAEEAVAKLQARIEDLERA 1126
             ++     E +K  +E  L+   A Q LR + E++    +K  EE     +A+I+++ + 
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193

Query: 1127 ISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQ 1186
             S    + + +  +++EQ   +     + +  LE ER     LA E+  L       E +
Sbjct: 1194 HS----QAVEELAEQLEQTKRVKANLEKAKQTLENER---GELANEVKVLLQGKGDSEHK 1246

Query: 1187 RPKV-----QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVL 1241
            R KV     +LQ + +E  +V  E   ++T+L+ +L  + G  S  + +  KL  D   L
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 1242 RAQKPTVEYKEVTQEVVRHERS-----PEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
             +Q    + +E+ QE  R + S      +V  E +  + QL E   +    ++Q+  L  
Sbjct: 1307 ESQ--LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 1297 ERDEWRR---------ERAKVETKTVSKEV----VRHEKDPV----LEKEAERLRQEVRE 1339
            +  + ++         E A+   + + K++     RHE+       LEK   RL+QE+ +
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 1340 AAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV--TQKDPKLREEHSR---LSGS 1394
                      +   L+ K+   ++   EEK +  +      + + + RE+ ++   L+ +
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 1395 LDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKL-AVERELRQLTLRIQELEKRP 1453
            L+E + ++ +LE   +Q R    E E L+S ++D  K +  +E+  R L  +++E++ + 
Sbjct: 1485 LEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541

Query: 1454 PTVQEKIIMEEVVKLEKDPDLEKSTEALRWDL----DQEKTQVTELNRECKNLQVQIDVL 1509
              +++++   E  KL  + +L+        DL    +Q + +  +L R+ + ++ +++  
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601

Query: 1510 QKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARR---LRE---- 1562
            +K +S      K++    KD     + A      NR+   +Q R+ +A+    +RE    
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSAN----KNRDEAIKQLRKLQAQMKDCMRELDDT 1657

Query: 1563 RIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQ 1622
            R  R E L      +  E ++     + E  +LQ+EL A ER K+    Q Q+E   L+ 
Sbjct: 1658 RASREEILA-----QAKENEKKLKSMEAEMIQLQEELAAAERAKR----QAQQERDELAD 1708

Query: 1623 KTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNL 1682
            +  +   K A   +E  RLEA I + ++++ E++     ++ ++ +  L  +    + NL
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768



 Score =  153 bits (387), Expect = 1e-36
 Identities = 241/1127 (21%), Positives = 483/1127 (42%), Gaps = 145/1127 (12%)

Query: 630  KAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCV 689
            K K  L + RQ  + + + +  E   V+E  + AE      R++E++  + +L+ ++   
Sbjct: 833  KVKPLLQVSRQ--EEEMMAKEEELVKVREKQLAAE-----NRLTEMETLQSQLMAEK--- 882

Query: 690  LRLHRALKASEHACA----------ALQNNFQEFCQDLP----RQQRQVRALTDRYHAVG 735
            L+L   L+A    CA          A +   +E C DL      ++ + + L      + 
Sbjct: 883  LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942

Query: 736  DQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQK---- 791
              +   E+ +++     Q+ +  K    + L+ L   Q+   D   ++A + +  +    
Sbjct: 943  QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002

Query: 792  ----RLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAV----SAPKR 843
                 LT+E + + +  A   +  +A+   L++   + +  R  LE T       S    
Sbjct: 1003 EFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061

Query: 844  PRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK--------KELSEDIR 895
             ++A LQ  I   +  LAK   E+ AA  ++ ++       L+K         EL ED+ 
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121

Query: 896  RTHDAKQGSESPAQ-AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQL--RTQRPLE 952
                ++  +E   +  G E EALK +LE+     A  Q EL ++R Q + +  +T     
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTA-AQQELRSKREQEVNILKKTLEEEA 1180

Query: 953  RLEEKEVVEFYRD---------PQLEGSLSRVKAQVEEEGK----RRAGLQADLEVAAQK 999
            +  E ++ E  +           QLE +  RVKA +E+  +     R  L  +++V  Q 
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQT-KRVKANLEKAKQTLENERGELANEVKVLLQG 1239

Query: 1000 VVQLESKRKTMQPHLLTKEVTQVERD---PGLDSQAAQLRIQIQQLRGEDAVISARLEGL 1056
                E KRK ++  L   +V   E +     L  +  +L++++  + G  +   ++   L
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299

Query: 1057 KKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQ---ALRLQMEEDAARRKQAEEAV 1113
             K+  ALE +  D +E +  +   K+  + ++ +      + R Q+EE+   +   E+ +
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359

Query: 1114 AKLQARIEDLERAIS-SVEPKVIVKEVK-KVEQD-PGLLQESSRLRSLLEEERTKNATLA 1170
            A L A++ D+++ +  SV      +EVK K+++D  GL Q      +  ++       L 
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419

Query: 1171 RELSDL-----HSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRS 1225
            +EL DL     H + S    ++ + +  + + E   +  +  +E  R +A+ +E   K  
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479

Query: 1226 GVEKEVEKLLP---DLEVLRAQKPTV------EYKEVTQEVVRHERSPEVL-REIDRLKA 1275
             + + +E+ +    +LE L  Q  T          +V + V   E+S   L ++++ +K 
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539

Query: 1276 QLNELVNSHGRSQEQLIRL---------QGERDEWRRERAKVETKTVSKEVVRHEKDPVL 1326
            QL EL +    +++  +RL         Q ERD   R+    E K   K++VR  ++   
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK---KQLVRQVREMEA 1596

Query: 1327 EKEAERLRQEVREAAQKR----------------RAAEDAVYELQS--------KRLLLE 1362
            E E ER ++ +  AA+K+                +  ++A+ +L+          R L +
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDD 1656

Query: 1363 RRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGL 1422
             R   E+++ Q     +K   +  E  +L   L      +RQ + E  +L   +    G 
Sbjct: 1657 TRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGK 1716

Query: 1423 LSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIME--EVVKLEKDPDLEKSTEA 1480
             +   +  ++L  E  + QL   ++E +     + +++     ++ ++  D +LE+S   
Sbjct: 1717 GALALEEKRRL--EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS--- 1771

Query: 1481 LRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVW 1540
                  + +    +L R+ K L+V+   LQ+ +   K+ YK  I       LE + A++ 
Sbjct: 1772 ---HAQKNENARQQLERQNKELKVK---LQEMEGTVKSKYKASITA-----LEAKIAQLE 1820

Query: 1541 EMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
            E L+ E   RQA  ++ RR  +++   + L +    E    ++ +DQAD+   RL+Q  R
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLK--DVLLQV-DDERRNAEQYKDQADKASTRLKQLKR 1877

Query: 1601 ALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILR 1647
             LE + +++  +     + L ++ E   + A    +E+S L+  + R
Sbjct: 1878 QLE-EAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923



 Score =  100 bits (249), Expect = 1e-20
 Identities = 235/1173 (20%), Positives = 476/1173 (40%), Gaps = 156/1173 (13%)

Query: 43   ISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVD 102
            ++ M+    Q+  + L+ Q++LQ +     +++ L+ +    +  +E E +  DL   V+
Sbjct: 868  LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK--QELEEICHDLEARVE 925

Query: 103  KAR-RLKHPQAEE--IEKDIKQLHERVTQE-CAEYRALYEKMVLPPDVGPRVDWARVLEQ 158
            +   R +H QAE+  ++++I++L E++ +E  A  +   EK+            A++ + 
Sbjct: 926  EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE---------AKLKKL 976

Query: 159  KQKQVCAGQYGPGMAE----LEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDL 214
            +++Q+        +A+    LE +IAE      E +   + L  L     A I +   + 
Sbjct: 977  EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-TDLEER 1035

Query: 215  LKAASWRGQSLGSLYTHLQGCTRQLS-ALAEQQRRI------LQQDWSDLMADPAGVRRE 267
            L+    + Q L      L+G +  LS  +AE Q +I      L +   +L A  A V  E
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095

Query: 268  --YEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP---IQAHQEALKMEWQNFLNLC 322
               ++    ++   E  +++L++D E     R+ A      +    EALK E ++ L+  
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155

Query: 323  ICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEE 382
              Q+      E   + ++E + + +TL +     +A+          A  EL +QLE  +
Sbjct: 1156 AAQQ------ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209

Query: 383  KRLAVTERATGDLQRRSRDVAP-----LPQRRNPPQQPLHVDSICDWDSGEVQLLQGERY 437
            +  A  E+A   L+    ++A      L  + +   +   V++       +V+  +GER 
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA--QLQELQVKFNEGERV 1267

Query: 438  K--LVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
            +  L D        +    G   ++               +++S+L  +  AL+ +L   
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSD--------------SKSSKLTKDFSALESQLQDT 1313

Query: 496  QSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSR 555
            Q  L+    + L  S +     D  N        Q+   +     +E+Q+          
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKN----SFREQLEEEEEAKHNLEKQIATLHAQVADM 1369

Query: 556  PTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKN 615
               +ED  G + + E   ++L          QK+ E          AA      L   K 
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKL----------QKDLEGLSQRHEEKVAAYD---KLEKTKT 1416

Query: 616  KFSDVQVLCSLYGEKAKAALDLERQIQDA---DRVIRGFEATLVQEAPIPAEPGALQERV 672
            +         L  E     +DL+ Q Q A   ++  + F+  L +E  I A      +  
Sbjct: 1417 R---------LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA------KYA 1461

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
             E  R   E  E++T  L L RAL+ +    A L+   ++F       + ++  L     
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF-------RTEMEDLMSSKD 1514

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQK- 791
             VG       K V +   + +  +   + + + LE L        D   ++   LQA K 
Sbjct: 1515 DVG-------KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 792  RLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPR--VAPL 849
            +  +++Q R+          +  Q   Q  E++A+      + ++AV+A K+    +  L
Sbjct: 1568 QFERDLQGRDEQSE-----EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622

Query: 850  QESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQ 909
            +  I +  KN  +A  ++   Q Q+    +  R++ + +   E+I       Q  E+  +
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQM---KDCMRELDDTRASREEI-----LAQAKENEKK 1674

Query: 910  AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLE 969
              +  EA   QL+EE     R + + + +R +L        +     K  +      +LE
Sbjct: 1675 L-KSMEAEMIQLQEELAAAERAKRQAQQERDELAD-----EIANSSGKGALALEEKRRLE 1728

Query: 970  GSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLD 1029
              +++++ ++EEE      +   L+ A  ++ Q+ +     + H    E  + +    L+
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ----LE 1784

Query: 1030 SQAAQLRIQIQQLRGE-DAVISARLEGLKKELLALEKR-EVDVKEK-VVVKEVVKVEKNL 1086
             Q  +L++++Q++ G   +   A +  L+ ++  LE++ + + KE+    K+V + EK L
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844

Query: 1087 EMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDP 1146
            + V       LQ++++    +Q ++   K   R++ L+R +   E     +E ++     
Sbjct: 1845 KDV------LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE-----EEAQRANASR 1893

Query: 1147 GLLQESSRLRSLLEEERTKNATLARELSDLHSK 1179
              LQ     R L +   T +A + RE+S L +K
Sbjct: 1894 RKLQ-----RELEDATETADA-MNREVSSLKNK 1920



 Score = 88.2 bits (217), Expect = 7e-17
 Identities = 120/535 (22%), Positives = 248/535 (46%), Gaps = 59/535 (11%)

Query: 1191 QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEV--EKLLPDLEVLRAQKPTV 1248
            +L  +V  + QV  + E+    + AK +E+   R   EK++  E  L ++E L++Q   +
Sbjct: 829  RLFTKVKPLLQVSRQEEE----MMAKEEELVKVR---EKQLAAENRLTEMETLQSQ--LM 879

Query: 1249 EYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQL---IRLQGERDEWRRER 1305
              K   QE ++ E   E+  E + L+A+L     +  +  E++   +  + E +E R + 
Sbjct: 880  AEKLQLQEQLQAET--ELCAEAEELRARLT----AKKQELEEICHDLEARVEEEEERCQH 933

Query: 1306 AKVETKTVSKEVVRHEKDPVLEKEAER---LRQEVREAAQKRRAAEDAVYELQSKRLLLE 1362
             + E K + + +   E+    E+ A +   L +   EA  K+   E  + E Q+ +L  E
Sbjct: 934  LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993

Query: 1363 RRKPEEKVVVQEVVVTQKDPK------LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGV 1416
            ++  E+++      +T+++ K      L+ +H  +   L+E + R  +   E+++ R  +
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

Query: 1417 EEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEK 1476
            E     LS Q    +    E ++ QL  + +EL+     V+E+   + +  L+K  +LE 
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKM-QLAKKEEELQAALARVEEEAAQKNMA-LKKIRELES 1111

Query: 1477 STEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDER 1536
                L+ DL+ E+    +  ++ ++L  +++ L+     E T+     + +     E E 
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKT--ELEDTLDSTAAQQELRSKREQEV 1169

Query: 1537 ARVWEMLNRERTARQAREEEARRLRERI--DRAETLGRTWSREESELQRARDQADQECGR 1594
              + + L  E    +A+ +E R+   +   + AE L +T  R ++ L++A+   + E G 
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQT-KRVKANLEKAKQTLENERGE 1228

Query: 1595 LQQELRAL-------ERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEA---- 1643
            L  E++ L       E ++++   QLQE   L  +  E ER +  +   ++++L+     
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQE---LQVKFNEGERVRT-ELADKVTKLQVELDN 1284

Query: 1644 --AILREKDQIYEKERTLRDLHAKVSR----EELSQETQTRETNLSTKISILEPE 1692
               +L + D   +  +  +D  A  S+    +EL QE   ++ +LSTK+  +E E
Sbjct: 1285 VTGLLSQSDS--KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 196/987 (19%), Positives = 380/987 (38%), Gaps = 144/987 (14%)

Query: 34   AATQELALLISRMQANADQVERD--ILETQ-------KRLQQDRLNSEQSQALQHQQETG 84
            +A Q+L L     +A   ++E +  ILE Q       K+L +DR+ +E +  L  ++E  
Sbjct: 957  SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI-AEFTTNLTEEEEKS 1015

Query: 85   RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQ---ECAEYRALYEKMV 141
            +SL + +   + +  D+++  R +  Q +E+EK  ++L    T    + AE +A   ++ 
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075

Query: 142  LP---PDVGPRVDWARVLEQKQKQVCA--------GQYGPGMAELEQQIAEHNILQKEID 190
            +     +   +   ARV E+  ++  A         Q      +LE + A  N  +K+  
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135

Query: 191  AYGQQLRSLVGPDAATI------------RSQYRDLLK------AASWRGQSLGSLYTHL 232
              G++L +L      T+            R Q  ++LK      A +   Q       H 
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 233  QGC---------TRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSV 283
            Q           T+++ A  E+ ++ L+ +  +L A+   V  + +   +H+    E  +
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGEL-ANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 284  NQLE---DDGERM------------VELRHPA--------------------VGPIQAHQ 308
             +L+   ++GER+            VEL +                         +Q  Q
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314

Query: 309  EALKMEWQNFLNLCICQETQLQHVED----YRRFQEEADSVSQTLAKLNSNLDAKYSPAP 364
            E L+ E +  L+L     T+L+ VED    +R   EE +     L K  + L A+ +   
Sbjct: 1315 ELLQEENRQKLSL----STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA--- 1367

Query: 365  GGPPGAPTELLQQLE--------AEEKRLAVTERATGDLQRRSRDVAP---LPQRRNPPQ 413
                    ++ +++E        AEE +  + +   G  QR    VA    L + +   Q
Sbjct: 1368 --------DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419

Query: 414  QPLHVDSICDWDSGEVQLLQGER-YKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDP 472
            Q L  D + D D         E+  K  D        +     E +    A         
Sbjct: 1420 QELD-DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478

Query: 473  DAVARASRLA----SELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLL 528
             ++ARA   A    +EL+ L ++  T    L +S  +  +   +          Q +++ 
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538

Query: 529  TQMTRLDGDLGQIERQVLAWARAPLSRPTPLE-DLEGRIHSHEGTAQRL----QSLGTEK 583
            TQ+  L+ +L   E   L       +     E DL+GR    E   ++L    + +  E 
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598

Query: 584  ETAQKECEAFLSTRPVGPAALQ-LPVALNSV-KNKFSDVQVLCSLYGEKAKAALDLERQI 641
            E  +K+    ++ R      L+ L   ++S  KN+   ++ L  L  +      +L+   
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658

Query: 642  QDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEH 701
               + ++   +    +   + AE   LQE ++  +R +R+  +Q+   L    A  + + 
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA-QQERDELADEIANSSGKG 1717

Query: 702  ACAA-----LQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFK 756
            A A      L+    +  ++L  +Q     + DR      Q+D     +       Q+ +
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777

Query: 757  NCKDNLSSWLEHLPRSQVRPSDGPSQIAYK-----LQAQ-KRLTQEIQSRERDRATASHL 810
            N +  L    + L + +++  +G  +  YK     L+A+  +L +++ +  ++R  A   
Sbjct: 1778 NARQQLERQNKEL-KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836

Query: 811  SQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAA 870
             +  +  L+D  LQ D  R + E     +     R+  L+  ++  E+   +A       
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 871  QQQLLQQLEFARKM-LEKKELSEDIRR 896
            Q++L    E A  M  E   L   +RR
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLRR 1923


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  153 bits (386), Expect = 2e-36
 Identities = 265/1330 (19%), Positives = 525/1330 (39%), Gaps = 167/1330 (12%)

Query: 474  AVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTR 533
            +VA   RL  E++A K +   +   ++                 D     A+  ++++  
Sbjct: 1011 SVADRLRLEEEVEACKARFQHLMKSME---------------NEDKEETVAKMYISELKN 1055

Query: 534  LDGDLGQIERQVLAWARAPLSRPTPLE---DLEGRIHSHEGTAQRLQSLGTEKETAQKEC 590
            +   L + E++V+   ++  S  T  +   D   RI   E T + LQ L ++ +    +C
Sbjct: 1056 IRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKC 1115

Query: 591  EAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRG 650
            ++FL   P   +   L   LN +  K   V  L ++Y  K K    + R IQDA+ +++G
Sbjct: 1116 DSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG 1175

Query: 651  FEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNF 710
            +E  L QE  + A+  AL+   S L+    ++ ++ +    L   +  ++     +    
Sbjct: 1176 YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLT 1235

Query: 711  QEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP 770
             E   DL R Q +   L +R+H V  QL++R+  ++        ++ C   L  W+E   
Sbjct: 1236 PERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETT 1295

Query: 771  RSQVRPSDGPSQ----IAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQAD 826
              Q     G ++    ++ +L  Q  L  EI+  +         SQ     ++DYELQ  
Sbjct: 1296 AQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM 1355

Query: 827  TYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLE 886
            TY+  +E +   S  KR R+    ++I  +  +L   YT +     Q ++ +  A + LE
Sbjct: 1356 TYKAFVE-SQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLE 1414

Query: 887  KKE--------------------LSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERK 926
            ++E                    +S   R T      SE+      E   L+ Q+  E  
Sbjct: 1415 EEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEEL 1474

Query: 927  RVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVE-------FYRD------PQLEGSLS 973
               + Q     + SQ+   +    L   E+K++ E        Y D       QL+   S
Sbjct: 1475 TTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQS 1534

Query: 974  RVKAQVEEE--GKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQ 1031
            ++  Q E++   K++      LE     V Q E      Q     ++++ ++++    S 
Sbjct: 1535 QLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN---QSD 1591

Query: 1032 AAQLRIQIQQLRGEDAVISARLEGL---------KKELLALEKREVDVKEKVVVKEVVKV 1082
               L+  IQ      A +   +EG           +EL AL ++    KE+    E ++ 
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EALQE 1648

Query: 1083 EKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPK--VIVKEVK 1140
            E  +   +  +A+   ++++  + K A+E +A+ + +I+ L   ++SV      ++  + 
Sbjct: 1649 ETRVAQKELEEAVTSALQQETEKSKAAKE-LAENKKKIDALLDWVTSVGSSGGQLLTNLP 1707

Query: 1141 KVEQDPGLLQESSRLRSL------------LEEERTKNATLARELSDLHSKYSVVEKQRP 1188
             +EQ  G   E   L +             L+++        +EL      + ++  Q  
Sbjct: 1708 GMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF-ILATQSA 1766

Query: 1189 KVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLR--AQKP 1246
            +  L +  H +      T +E   L+ KL E+  + S    + E  L  ++ L+   QK 
Sbjct: 1767 QAFLDQHGHNL------TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKF 1820

Query: 1247 TVEYKEVTQEVVRHER----------SPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQG 1296
              ++KE    + R E+          SPE L  + + +   +E V SH +   + + + G
Sbjct: 1821 LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH-KGDLRFVTISG 1879

Query: 1297 ER-----DEWRRERAKVETKTVSKEVVRH--EKDPVLEKEAERLRQEVREAAQKRRAAED 1349
            ++     + ++  +   E   + K+ ++   E+   L  +  RL   +     +    ++
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939

Query: 1350 AVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEV 1409
            +   LQ+     E     EK++   V     DP + +E    +  L EE+   +    ++
Sbjct: 1940 SADSLQAWMQACEAN--VEKLLSDTVA---SDPGVLQEQLATTKQLQEELAEHQVPVEKL 1994

Query: 1410 QQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLE 1469
            Q++   + E EG  +  + R  +   +  L         L +R   +Q+ I   + V+  
Sbjct: 1995 QKVARDIMEIEGEPA-PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053

Query: 1470 KDPDLEKSTEALRWDLDQEKTQVTELNRE------CKNLQVQIDVLQKAKSQEK-----T 1518
             +  L+   E    + + E  QV+ L+          N++++ D+ ++  S E      T
Sbjct: 2054 LESLLQSIGEV---EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT 2110

Query: 1519 IYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLG---RTWS 1575
             + E        VL+ + A V +   +    +Q +E   ++L  + +  E L    + + 
Sbjct: 2111 RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170

Query: 1576 REESELQRARDQADQECGRLQQELRA--LERQKQQQTLQLQEE--SKLLS---------- 1621
              +S +  + +Q DQ+     Q+++   LE + QQ+ L   E   ++L S          
Sbjct: 2171 ENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQH 2230

Query: 1622 --------------QKTESERQKAAQRGQE-LSRLEAAILREKDQIYEKERTLRDLHAKV 1666
                          QKT  ER+K A   QE L      +   +  + E E ++      +
Sbjct: 2231 QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2290

Query: 1667 SREELSQETQ 1676
            S +EL ++ +
Sbjct: 2291 SAKELEKQIE 2300



 Score =  125 bits (315), Expect = 3e-28
 Identities = 113/523 (21%), Positives = 208/523 (39%), Gaps = 70/523 (13%)

Query: 33  RAATQELALLI---SRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKE 89
           R A + L LL+   +++Q  A   E  +   +  LQ D  + E  Q +Q + +    ++E
Sbjct: 420 RPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQE 479

Query: 90  AEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEK------MVLP 143
            E L++ L +D+   R   + Q EE+   + +L + +     E   LY K       ++P
Sbjct: 480 CEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVP 539

Query: 144 PDV----------------GPRVDWARV----------------------------LEQK 159
           P                       W R                             +E+ 
Sbjct: 540 PSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEM 599

Query: 160 QKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYG--------------QQLRSLVGPDAA 205
           Q ++   ++G  +  +E Q+     +   ++  G              Q   +       
Sbjct: 600 QMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLG 659

Query: 206 TIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVR 265
            + +QY  L + +S+R + L SL+  +   T +L  L E++   L  DWSD  ++ +  R
Sbjct: 660 KLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKR 719

Query: 266 REYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQ 325
             +      EL  ++     L+D  E +    HPA   ++A+  A++ + Q    LC+C 
Sbjct: 720 NYFSELTM-ELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCV 778

Query: 326 ETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRL 385
           E  ++    Y +F  +A  +   L  L  ++  KYS           +LLQ    E+++L
Sbjct: 779 EQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQL 838

Query: 386 AVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNT 443
             ++ +   L  RS+ +  L  R   +  +  + V ++CD+   E+ + + +   L DN+
Sbjct: 839 IQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNS 898

Query: 444 DPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQ 486
               W V  P G     P+ CF IP P+ DA+  ASR+    Q
Sbjct: 899 QRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQ 941



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 354/1891 (18%), Positives = 712/1891 (37%), Gaps = 331/1891 (17%)

Query: 24   PKGSPSRHSRAATQELALLISRMQANADQVERDILETQKRLQQDRLNSE-QSQALQHQQE 82
            P+     H     Q+     SRM A+ +Q ++DI    +++Q+  L  E Q + L   + 
Sbjct: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213

Query: 83   TGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVL 142
                L      L DL    D+ + L+     E++K +K+  E+    C E    + K+V 
Sbjct: 2214 LVTELSSCGFAL-DLCQHQDRVQNLR-KDFTELQKTVKE-REKDASSCQEQLDEFRKLVR 2270

Query: 143  PPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQI----------AEHNILQKEIDAY 192
                     + + L++ +  +   +      ELE+QI          A    L +EI+  
Sbjct: 2271 --------TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2322

Query: 193  GQQLRSLV----GPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRR 248
            G  L +L+     PD+   + +   +L +    G S+GS+  +   C             
Sbjct: 2323 GTSLENLIMEITAPDS---QGKTGSILPSV---GSSVGSVNGY-HTC------------- 2362

Query: 249  ILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQ 308
               +D +++  D + V  +YE      L  +++S+  + +  E + +  +  +  +++ +
Sbjct: 2363 ---KDLTEIQCDMSDVNLKYEKL-GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418

Query: 309  EALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPP 368
            E LK    + ++     ET     E  + F  E +  S  + K+   L       P    
Sbjct: 2419 EVLKS--MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQE 2476

Query: 369  GAPTELLQ-QLEAE-EKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQ------------ 414
                + +Q +L +  E+   VT      L+  +  +A      +  +             
Sbjct: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536

Query: 415  -PLHVD-SICDWDSGEVQLL----QGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIP 468
             PL +D ++ +    +VQ +    +  R +     +    ++ GPG              
Sbjct: 2537 GPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPG-------------- 2582

Query: 469  APDPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLL 528
                D     S++  ELQ++ QK   +  +L +      R SQ           QA    
Sbjct: 2583 ----DVSLSTSQVQKELQSINQKWVELTDKLNS------RSSQ---------IDQAIVKS 2623

Query: 529  TQMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
            TQ   L  DL +  R V        +  T  E ++ ++         L+ L  E + AQ 
Sbjct: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683

Query: 589  ECEAFLSTRPVGPAAL--QLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADR 646
             C+    +  +G   L  +L   L +V      ++ L +    + +AAL   +Q Q    
Sbjct: 2684 LCDEL--SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741

Query: 647  VIRGF----EATLVQEAPIPAEPGALQERVSELQRQRREL-------------------- 682
             +R +    ++   +  PI A+   LQ ++ E +  ++ L                    
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801

Query: 683  ---------LEQQTCVLRLHRALKASEHA--------CAALQNNFQEFCQDLPRQQRQVR 725
                     L+ Q   L+ H    + + A        C      +Q   +DL       +
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861

Query: 726  ALTDRYHAVGDQLDLREKVVQDAAL--TYQQFKNCKDNLSSWLEHLPRSQVRPSDG-PSQ 782
            A         D + L   +++  A+    ++ ++  + L+S  + L  S     DG   +
Sbjct: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDE 2921

Query: 783  IAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLE-----PTLA 837
             A   Q    +T+E+Q++       +   +  Q + ++ E + +  +  LE      + A
Sbjct: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQA 2981

Query: 838  VSAPKRPRVAPLQESIQAQE------KNLAKAYTEVA---AAQQQLLQQLEFARK----- 883
             S     ++   QE +QA E      +N  +   E A   +   QLL Q E A++     
Sbjct: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041

Query: 884  ---------MLEKK---------ELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEER 925
                     M+E K          + E   +  D     +     GR++++L++Q+E+ R
Sbjct: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVR 3101

Query: 926  ---KRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEE 982
                ++  ++ ++EA  ++   +        LEE+  ++     +   +L++   ++ E 
Sbjct: 3102 LFLNKIHVLKLDIEASEAECRHM--------LEEEGTLDLLGLKRELEALNKQCGKLTER 3153

Query: 983  GKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEV---------TQVERDPGLDSQAA 1033
            GK R   Q  LE+   +V     K K +       E          T+VE    ++ Q A
Sbjct: 3154 GKAR---QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI---INQQLA 3207

Query: 1034 QLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQ 1093
              ++  ++      +   ++ GL + L+    ++ DV+      E +    N    K AQ
Sbjct: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267

Query: 1094 ALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEP-----KVIVKEVKKVEQDPGL 1148
             +  Q++E      + ++A+  L + + D E  I++ +P     KV+  ++++ +    L
Sbjct: 3268 RI-AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL 3326

Query: 1149 LQESSRLRSLLEEERTKNA----------------TLARELSDLHSKYSVVEKQRPKV-- 1190
            L +      +L+ E  + A                +L    ++L SK +  +KQ   +  
Sbjct: 3327 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILV 3386

Query: 1191 ---QLQERVHEIFQVDPETEQEITRLK------AKLQEMAGKRSGVEKEVEKLLPDLEVL 1241
               Q  E    I      TE+++   +      AK+Q+   +   +E+++E    D+   
Sbjct: 3387 LAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH-- 3444

Query: 1242 RAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQL------IRLQ 1295
                  V+  +    +        +  +ID L+A+ +E+ +   R    L       RL 
Sbjct: 3445 ----QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF 3500

Query: 1296 GERD-EWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYEL 1354
            GE + E     A+VE K  S  V   ++D +  + A+ L     E   +++  + A+   
Sbjct: 3501 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN-EEIVNRKKNVDQAI--- 3556

Query: 1355 QSKRLLLERRKPEEKVVVQE-----------VVVTQKD-----PKLREEHSRLSGSLDEE 1398
            ++ + LL++   EE +++QE           + VT         + R+  ++   + +E 
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 3616

Query: 1399 VGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTL-RIQELEKRPPTVQ 1457
             G  R++E E+          E +  FQ+ R K+L  E    +L L  + E+ +    + 
Sbjct: 3617 TGWLREVEEELATSGGQSPTGEQIPQFQQ-RQKELKKEVMEHRLVLDTVNEVSRALLELV 3675

Query: 1458 EKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQ-----VQIDVLQKA 1512
                 E + KL  D     + E  +   D    +V E++   +  Q        ++   A
Sbjct: 3676 PWRAREGLDKLVSD-----ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVA 3730

Query: 1513 KSQEKTIYKEVIRVQKDRV---LEDERARVWEML-----------NRERTARQAREEEAR 1558
            +++ K +    IR+++D+    L+ ++A   +++           +R        EE+  
Sbjct: 3731 ETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKT 3790

Query: 1559 RLRER----IDRAETLGRTWSREESELQRARDQADQ------ECGRLQQELRALERQ--- 1605
             L+E+    I + E +    S   + L+RA+   +Q      E     +E RAL  Q   
Sbjct: 3791 VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPS 3850

Query: 1606 ---KQQQTLQLQEESKLLSQKTESER---QKAAQRGQELSRLEAAILREKDQIYEKERTL 1659
                 +Q  Q QEE + L +     +    K  + G +L  L      E + + EK +  
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP---EEGEMVEEKYQKA 3907

Query: 1660 RDLHAKVSREELSQETQTRETNLSTKISILE 1690
             +++A++ +EE+ Q     +  +S    I E
Sbjct: 3908 ENMYAQI-KEEVRQRALALDEAVSQSTQITE 3937



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 318/1745 (18%), Positives = 644/1745 (36%), Gaps = 246/1745 (14%)

Query: 50   ADQVERDILETQKRLQQDRLNS------EQSQALQ-HQQETGR----SLKEAEVLLKDLF 98
            A Q E+  L+ Q+     +L        +  +AL  HQ  T +    +L++ +  LKDL 
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 1596

Query: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQ 158
             D+           ++IE  +++   +++    E  AL EK                L Q
Sbjct: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSPR--ELTALREK----------------LHQ 1638

Query: 159  KQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAA 218
             ++Q  A Q    +A+ E + A  + LQ+E +      +S    + A  + +   LL   
Sbjct: 1639 AKEQYEALQEETRVAQKELEEAVTSALQQETE------KSKAAKELAENKKKIDALLDWV 1692

Query: 219  SWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFK--QHEL 276
            +  G S G L T+L G  +   A  E+        +  +   P  + ++ E  K    EL
Sbjct: 1693 TSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQEL 1752

Query: 277  LSQEQSVNQLEDDGERMVELRHPAVGP-----IQAHQEALKMEWQNFLNLCICQETQLQH 331
            LSQ+Q+        +  ++     + P     +Q     LK ++   L     +  Q+Q 
Sbjct: 1753 LSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQT 1812

Query: 332  VED-YRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEE-------- 382
            ++D  ++F ++       L +    L+  +      P   P+ L +Q    E        
Sbjct: 1813 LQDELQKFLQDHKEFESWLERSEKELENMHKGG-SSPETLPSLLKRQGSFSEDVISHKGD 1871

Query: 383  -KRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLH--------VDSICDWDSGEVQLLQ 433
             + + ++ +   D++   ++     +  N  +  L         + S C      + +L 
Sbjct: 1872 LRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLL 1931

Query: 434  GERYKLVDNTDP-HAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL---QALK 489
            G+ ++  ++ D   AW+        K         P    + +A   +L  EL   Q   
Sbjct: 1932 GQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPV 1991

Query: 490  QKLATV-------------QSRLKASAVESLRPSQQAPSGS--------DLANPQAQKLL 528
            +KL  V               R      +S+    Q+ S S          A  Q+Q + 
Sbjct: 1992 EKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQ 2051

Query: 529  TQMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQK 588
              +  L   +G++E+ +     + LS     E L   +   +  A++  SL   +E   +
Sbjct: 2052 ESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR 2111

Query: 589  ECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI 648
              E   ST      A  L   L  V  +F     LC    EK  +   L  Q +  + + 
Sbjct: 2112 FMETADST-----TAAVLQGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLS 2163

Query: 649  RGFEATLVQEAPIPAEPGALQERVSELQRQRREL---LEQQTCVLRLHRALKASEHACAA 705
               +  +  ++ + A      + ++   +Q +EL   +E Q         L   EH    
Sbjct: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQ------QENLDTLEHLVTE 2217

Query: 706  LQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSW 765
            L +    F  DL + Q +V+ L   +  +   +  REK          +F+        W
Sbjct: 2218 LSSC--GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKW 2275

Query: 766  LEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQA 825
            L+     +   S  P++ +   +  ++  + ++S   D A+   L + +       E   
Sbjct: 2276 LK-----ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE--- 2327

Query: 826  DTYRCSLEPTLAVSAPKRPRVAPLQES-----------------------IQAQEKNLAK 862
                  +E T   S  K   + P   S                       +  + + L  
Sbjct: 2328 ---NLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGG 2384

Query: 863  AYTEVAAAQQQLLQQLEFARK----MLEKKELSEDIRRTHDAKQGSESPAQAGRESEALK 918
               E   + Q +L ++E   K    +L+  E  E++ ++ DA            ++E+ K
Sbjct: 2385 VLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNK 2444

Query: 919  AQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQ 978
            A L E  +   ++Q   EA    L+     +  E  ++ +                + ++
Sbjct: 2445 AFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ--------------EELNSR 2490

Query: 979  VEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQ-----VERDPG-LDSQA 1032
             E   +     Q  LE +A  +   ++    ++P L+ KE+       +  DP  L++Q 
Sbjct: 2491 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 2550

Query: 1033 AQLRIQIQQL---RGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKV-EKNLEM 1088
             Q++  +++    R +   ++   +G+          +V +    V KE+  + +K +E+
Sbjct: 2551 QQVQFMLKEFEARRQQHEQLNEAAQGI-----LTGPGDVSLSTSQVQKELQSINQKWVEL 2605

Query: 1089 VKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGL 1148
                 +   Q+++   +  Q +E +  L  ++  + + +S      I  + + V+Q    
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV--QSAISTQPEAVKQQ--- 2660

Query: 1149 LQESSRLRSLLEE---ERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
            L+E+S +RS LE+   E  +  TL  ELS L  +  +  K   K +L+     +  ++  
Sbjct: 2661 LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL--KDELKKRLETVALPLQGLEDL 2718

Query: 1206 TEQEITRLKAKL--------------------QEMAGKRSGVEKEVEKLLPDLEVLRAQK 1245
                I RL+A L                    Q    K   +  ++E+L   L+     +
Sbjct: 2719 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 2778

Query: 1246 PTVEYKEVTQEVVRHERSPEVL-----REIDRLKAQLNELVNS----HGRSQEQLIRLQ- 1295
             ++     + EV+  E    +L      E   L+ QL EL N       ++ ++  RL+ 
Sbjct: 2779 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 2838

Query: 1296 ----GERDEWRRERAK--VETKTVSKEVVRHEKDPV-LEKEAERLRQEVREAAQKRRAAE 1348
                 ++ +W  E     +E        +R   DPV LE    R +  + E  ++R   E
Sbjct: 2839 CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLE 2898

Query: 1349 DAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELE 1408
              +    +  L+      E+ +  ++  + Q    + EE    +GSL+E   R R+ +  
Sbjct: 2899 --ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956

Query: 1409 VQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKL 1468
             + +   VE  +  L   +    +    + L +L  + + L+   P V       + + +
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL-V 3015

Query: 1469 EKDPDLEKSTEALRWD--LDQEKTQVTE-LNRECKNLQVQIDVLQKAKSQEKTIYKEVIR 1525
            E  PD   +++ L       QE  +V + +N  C  ++ +++ + +   + + ++ ++  
Sbjct: 3016 EDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLAD 3075

Query: 1526 VQKDRVLEDERARVWEMLNRERTARQAREEEARR-------LRERIDRAETLGRTWSREE 1578
            +       D+       + R+  + Q++ E+ R        L+  I+ +E   R    EE
Sbjct: 3076 L-------DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEE 3128

Query: 1579 SE-----LQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQ 1633
                   L+R  +  +++CG+L +  R   RQ+Q +    + E      K  ++   AA+
Sbjct: 3129 GTLDLLGLKRELEALNKQCGKLTE--RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3186

Query: 1634 RGQEL 1638
              + L
Sbjct: 3187 EAEAL 3191



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 341/1789 (19%), Positives = 689/1789 (38%), Gaps = 281/1789 (15%)

Query: 49   NADQVERDILETQKRLQQ--DRLNSEQSQALQ------HQQETGRSLKEA------EVLL 94
            +  QV++++    ++  +  D+LNS  SQ  Q        QE  + L E        + +
Sbjct: 2587 STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 2646

Query: 95   KDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQE---CAEYRALYEKMVLPPDVGPRVD 151
            +       +A + +  +  EI  D++QL   V +    C E   L  +  L  ++  R++
Sbjct: 2647 QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE 2706

Query: 152  WARVLEQKQKQVCAGQYG---PGMAELEQQIAEHNILQKEID-AYGQQLRSL-VGPDAAT 206
               +  Q  + + A +       +A  +Q     + L+  +D    QQ ++  +      
Sbjct: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766

Query: 207  IRSQYRDLLKAASWRGQSLGSLYTHL-QGCTRQLSALAEQQRRILQQD-------WSDLM 258
            ++SQ ++  +      Q  GS    + +G +  LS    +++R LQ         W +L 
Sbjct: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826

Query: 259  ADPAGVRREYEHFKQHELLSQ---EQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEW 315
               A  +   +   Q     Q   E  V  +ED   +M ELR   + P+Q     L+   
Sbjct: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR-VTLDPVQLESSLLR--- 2882

Query: 316  QNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELL 375
                      +  L  VE  R   E           LNS  D   + +     G   E  
Sbjct: 2883 ---------SKAMLNEVEKRRSLLEI----------LNSAADILINSSEADEDGIRDE-- 2921

Query: 376  QQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPL-HVDSICDWDSGEVQLL-- 432
             +    +   AVTE    +LQ ++  +  + QR    Q+   +++   +    ++++   
Sbjct: 2922 -KAGINQNMDAVTE----ELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDA 2976

Query: 433  ---QGERYKLVDNTDPHAWVVQG--PGGETKRAPAACFCIPAPDPDAVARASRLASELQA 487
               Q    K ++       V+Q   P  +  R         APD    + AS+L  + + 
Sbjct: 2977 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDG---SDASQLLHQAEV 3033

Query: 488  LKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLA 547
             +Q+   V+ R+ +  V      +    G    + + +++ +Q+  LD +L  +      
Sbjct: 3034 AQQEFLEVKQRVNSGCVMM----ENKLEGIGQFHCRVREMFSQLADLDDELDGM------ 3083

Query: 548  WARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLP 607
                 + R T  + L+ +I        ++  L  + E ++ EC   L             
Sbjct: 3084 ---GAIGRDT--DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT-------- 3130

Query: 608  VALNSVKNKFSDVQVLCSLYGEKAKAALD-LER---QIQDADRVIRGFE--ATLVQEAP- 660
            + L  +K +   +   C    E+ KA  + LE    +++D  R ++G     T  +EA  
Sbjct: 3131 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3190

Query: 661  ----IPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQD 716
                +  E   + +++++ +  ++E ++       L   L+        L  +  + C D
Sbjct: 3191 LQWVVGTEVEIINQQLADFKMFQKEQVDP------LQMKLQQVNGLGQGLIQSAGKDC-D 3243

Query: 717  LPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWL---EHLPRSQ 773
            +   +  +  +  R++ +  ++  R   +Q+A L   +F++  + L SWL   E L  +Q
Sbjct: 3244 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303

Query: 774  VRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLE 833
              PS     +  ++Q QK L + +  R   +AT                LQA+  R +  
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDR---KATVD-------------MLQAEGGRIAQS 3347

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSED 893
              LA     R ++    ES++++   L    ++ AA Q+QL   L  A++  E  E   D
Sbjct: 3348 AELA----DREKITGQLESLESRWTEL---LSKAAARQKQLEDILVLAKQFHETAEPISD 3400

Query: 894  IRRTHDAKQGSESPAQAGRESEALKAQ------LEEERKRVARVQHELEAQRSQLLQLRT 947
                 + K  +  P   G ++  ++ Q      LEE+ +  A   H+       L  L +
Sbjct: 3401 FLSVTEKKLANSEP--VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3458

Query: 948  QRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQK-VVQLESK 1006
                  L EK      R  +++    R KA + ++    A L  + EV     + ++E K
Sbjct: 3459 PAEQGVLSEKIDSLQARYSEIQDRCCR-KAALLDQALSNARLFGEDEVEVLNWLAEVEDK 3517

Query: 1007 RKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKR 1066
              ++      ++V                   + +   +   ++  +   KK +    K 
Sbjct: 3518 LSSVFVKDFKQDV-------------------LHRQHADHLALNEEIVNRKKNVDQAIKN 3558

Query: 1067 EVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARR-KQAEEAVAKLQARIEDLER 1125
               + ++   +EV+ +++ L+ +K   A        A R  +QA +   K Q+  E+L  
Sbjct: 3559 GQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTG 3618

Query: 1126 AISSVEPKVIVK--EVKKVEQDPGLLQESSRLRSLLEEERTKNATL-------------- 1169
             +  VE ++     +    EQ P   Q    L+  + E R    T+              
Sbjct: 3619 WLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWR 3678

Query: 1170 ARE-----LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKR 1224
            ARE     +SD + +Y +V        + +RV EI      ++Q      A+L  +A  +
Sbjct: 3679 AREGLDKLVSDANEQYKLVSD-----TIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 3733

Query: 1225 ------SGVEKEVEKLLPDLEVLRA-QKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQL 1277
                    +  E ++    L+V +A     + +K+   E+  H RS       +  K  L
Sbjct: 3734 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSH-RSEIFGTCGEEQKTVL 3792

Query: 1278 NELVNSHGRSQEQLIRLQGERDEWRRERAKV-----------------ETKTVSKEV--- 1317
             E   S  +  E +  L  ER   R ERA+V                 ET+ +  ++   
Sbjct: 3793 QEKTESLIQQYEAISLLNSERYA-RLERAQVLVNQFWETYEELSPWIEETRALIAQLPSP 3851

Query: 1318 -VRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVV 1376
             + HE+   L ++ E +RQ +RE+  + +   D + ++  +   L+   PEE  +V+E  
Sbjct: 3852 AIDHEQ---LRQQQEEMRQ-LRESIAEHKPHIDKLLKIGPQ---LKELNPEEGEMVEEKY 3904

Query: 1377 VTQKD--PKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLS---------F 1425
               ++   +++EE  + + +LDE V +  Q+     ++   +E  E L S          
Sbjct: 3905 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 3964

Query: 1426 QEDRSKKLAVERELRQLTLRIQELEKRPPTVQE-KIIMEEVVKLEKDPDLEKSTEALRWD 1484
            + D+ ++   + +   +     ELEK  P+ +  K   EE++   +  D + + + ++  
Sbjct: 3965 EVDKIRECISDNKSATV-----ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019

Query: 1485 LDQEKTQVTELNRECKNLQVQ-IDVLQKAKS--QEKTIYKEVIRVQKDRVLEDERARV-W 1540
            LDQ      ++    +  +++ +DVL+ A+    +       I+  +D V + E   +  
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079

Query: 1541 EMLNRERTARQAREEEARRLRERIDRAETLG-----RTWSREESELQRARDQADQECGRL 1595
             ++ ++  A +  +EE   L E ++    LG          E+ E++++ D+ +     L
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4139

Query: 1596 ----QQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQR---GQELSRLEAAILRE 1648
                ++ L  LE    Q  +Q Q+  + +    ++   K       G +L+ +       
Sbjct: 4140 NKTWKERLEKLE-DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTV------- 4191

Query: 1649 KDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDM 1697
            KDQ+ E    +++   +V ++++  E    +  L  K +    ET +D+
Sbjct: 4192 KDQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKKA--TDETDRDI 4234



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 278/1455 (19%), Positives = 540/1455 (37%), Gaps = 231/1455 (15%)

Query: 34   AATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVL 93
            A T+EL        A    V+  I E  ++L Q  L+  ++     Q E GR  + AE+ 
Sbjct: 3294 ADTEELIANQKPPSAEYKVVKAQIQE--QKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351

Query: 94   LKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPD----VGPR 149
             ++              Q E +E    +L   +++  A  + L + +VL         P 
Sbjct: 3352 DREKITG----------QLESLESRWTEL---LSKAAARQKQLEDILVLAKQFHETAEPI 3398

Query: 150  VDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAY----------GQQLRSL 199
             D+  V E+K     +   G   A+++QQI  H  L+++I+ +          GQ L SL
Sbjct: 3399 SDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3456

Query: 200  VGPDAATIRSQYRDLLKA------------ASWRGQSLGSLYTHLQGCTRQLSALAEQQR 247
              P    + S+  D L+A            A+   Q+L +     +     L+ LAE + 
Sbjct: 3457 TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVED 3516

Query: 248  RILQQDWSDLMADPAGVRREYEHFK-QHELLSQEQSVNQLEDDGERMVELRHPAVGPIQA 306
            ++      D   D    R+  +H     E+++++++V+Q   +G+ +  L+      +  
Sbjct: 3517 KLSSVFVKDFKQDVLH-RQHADHLALNEEIVNRKKNVDQAIKNGQAL--LKQTTGEEVLL 3573

Query: 307  HQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPG- 365
             QE L      + ++ +     L+ +E  R+   +  S  + L      ++ + + + G 
Sbjct: 3574 IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ 3633

Query: 366  GPPGAPTELLQQLEAEEKRLAVTER----ATGDLQRRSRDVAPLPQRRN--------PPQ 413
             P G      QQ + E K+  +  R       ++ R   ++ P   R            Q
Sbjct: 3634 SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQ 3693

Query: 414  QPLHVDSICD-WDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDP 472
              L  D+I    D  +  + + ++Y+   + +  AWV      ETKR   A   I     
Sbjct: 3694 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE-LAWV-----AETKRKLMALGPIRLEQD 3747

Query: 473  DAVARAS-RLASELQALKQK-------------LATVQSRLKASAVESLRPSQQAPSGSD 518
               A+   + A  +  ++ K               T     K    E      Q      
Sbjct: 3748 QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS 3807

Query: 519  LANPQAQKLLTQMTRLDGDLGQIERQVLAW---ARAPLSR-PTPLEDLEGRIHSHEGTAQ 574
            L N +    L +   L     +   ++  W    RA +++ P+P  D E      E   Q
Sbjct: 3808 LLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867

Query: 575  RLQSLGTEKETAQKECEAFLSTRPVGPAALQL-PVALNSVKNKFSDVQ-VLCSLYGEKAK 632
              +S+   K    K  +       +GP   +L P     V+ K+   + +   +  E  +
Sbjct: 3868 LRESIAEHKPHIDKLLK-------IGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 3920

Query: 633  AALDLERQIQDADRV-------------IRGFEATLVQEAPIPAEPGALQERVSELQRQR 679
             AL L+  +  + ++             +    + L     IPAE   ++E +S+ +   
Sbjct: 3921 RALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 3980

Query: 680  RELLEQQTCVLRLHRALKA---------SEHACAALQNNFQE---FCQDLP--RQQRQVR 725
             EL + Q     L R  +           + A   +Q+   +   F +D+    ++R+++
Sbjct: 3981 VELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIK 4040

Query: 726  ALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAY 785
             L        D L+L EK   D A      K+ +D        +      P   PS I  
Sbjct: 4041 FL--------DVLELAEKFWYDMAALLTTIKDTQD--------IVHDLESPGIDPSIIKQ 4084

Query: 786  KLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPR 845
            +++A + + +E      +      L   L                      A    ++P 
Sbjct: 4085 QVEAAETIKEETDGLHEELEFIRILGADL--------------------IFACGETEKPE 4124

Query: 846  VAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSE 905
            V    + +    +NL K + E     ++L   ++ A +  +  +   D       K  + 
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKE---RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4181

Query: 906  SPAQAGRESEALKAQLEEERK-RVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYR 964
             P   G +   +K QL E ++ +V   Q ++E ++   L  + +  L++  ++   +  R
Sbjct: 4182 PP--VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK---LNHQGELMLKKATDETDRDIIR 4236

Query: 965  DPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLL-TKEVTQVE 1023
            +P     L+ +K   E  G++ A  Q  LE A   + Q +   + +   L  T+E+   +
Sbjct: 4237 EP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4291

Query: 1024 RDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVE 1083
            R    D +  ++ +             A+   LK ++LA          +  V+ V K  
Sbjct: 4292 RPISGDPKVIEVEL-------------AKHHVLKNDVLA---------HQATVETVNKAG 4329

Query: 1084 KNLEMVKA---AQALRLQMEED----AARRKQAEEAVAKLQARIEDLERAISSVEPKVIV 1136
              L    A   A +LR ++E       +  ++ EE   +LQ+ ++  +   S +E  ++ 
Sbjct: 4330 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL- 4388

Query: 1137 KEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERV 1196
             E+ ++E     L  S     L E  R +  T     S L +K     +   K +L    
Sbjct: 4389 -ELTRMESQ---LSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4444

Query: 1197 HEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLP-DLEVLRAQKPTVEYKEVTQ 1255
             +      +TEQ +  L+ K   ++ K    + ++E+ L    E   + +  + +  + +
Sbjct: 4445 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504

Query: 1256 EVVRHERSPE-----VLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310
            + +     P      VL +I+  K   NE VN+H   ++Q+I L    ++ +    K + 
Sbjct: 4505 QSLNIASPPSLILNTVLSQIEEHKVFANE-VNAH---RDQIIELDQTGNQLKFLSQKQDV 4560

Query: 1311 KTVSKEVVRHEK--DPVLEKEAERLR--QEVREAAQKRRAA--------EDAVYELQSKR 1358
              +   +V  +   + V+++  ER R   + R+ A++   A        EDA   L S+ 
Sbjct: 4561 VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSE- 4619

Query: 1359 LLLERRKPEEKVVVQ 1373
              LE     +K+ +Q
Sbjct: 4620 --LEISNDPDKIKLQ 4632


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  146 bits (369), Expect = 2e-34
 Identities = 198/854 (23%), Positives = 372/854 (43%), Gaps = 142/854 (16%)

Query: 878  LEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEA 937
            L+  R+  E +   +++++T + +Q +E+     +E E   +QL EE+  +   Q +L+A
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENEL---KELEQKHSQLTEEKNLL---QEQLQA 898

Query: 938  QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAA 997
            +     +    R   RL  K+        +LE  L  ++A++EEE  R   LQA+ +  A
Sbjct: 899  ETELYAEAEEMRV--RLAAKK-------QELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 998  QKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLK 1057
            Q+++ LE +   ++     ++  Q+E+             +I++L  E  V+  +   L 
Sbjct: 950  QQMLDLEEQ---LEEEEAARQKLQLEK--------VTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 1058 KELLALEKREVDV-----KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA 1112
            KE   LE+R  D+     +E+   K + K++   E + +   +RL+ EE +  R++ E+ 
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--RQELEKL 1056

Query: 1113 VAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARE 1172
              KL+    D    I+ ++ ++   +++                 L ++E    A LAR 
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQAALARL 1099

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
              ++  K + ++K R                 E E  I+ L+  L      R+  EK+  
Sbjct: 1100 DDEIAQKNNALKKIR-----------------ELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL-------REIDRLKAQLNELVNSHG 1285
             L  +LE L+ +         TQ+ +R +R  EV         E    +AQ+ E+   H 
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 1286 RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRR 1345
            ++ E+L     + ++++R +A ++    + E    +++  L  E   L Q  +E   K++
Sbjct: 1203 QAVEELTE---QLEQFKRAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKK 1255

Query: 1346 AAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQL 1405
              E  V ELQSK    ER + E         +  K  KL+ E   ++G L+E  G+  +L
Sbjct: 1256 KLEAQVQELQSKCSDGERARAE---------LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306

Query: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKR-PPTVQEKIIMEE 1464
              +V  L + +++ + LL  QE+  +KL V  +LRQL      L+ +    ++ K  +E 
Sbjct: 1307 AKDVASLSSQLQDTQELL--QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 1465 VVKL---------EKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ 1515
             +           +K  D   + EAL     + + ++  L ++ +      D L+K K++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 1516 -EKTIYKEVIRVQKDRVLE---DERARVWEML-------------NRERTARQAREEE-- 1556
             ++ +   V+ +   R L    +++ R ++ L              R+R   +ARE+E  
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1557 ----ARRLRERIDRAETLGRT---WSREESELQRARDQADQECGRLQQELRALERQKQQQ 1609
                AR L E ++  E L RT      E  +L  ++D   +    L++  RALE Q ++ 
Sbjct: 1485 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544

Query: 1610 TLQLQE-ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668
              QL+E E +L  Q TE  +           RLE  +   K Q +E++   RD   +  R
Sbjct: 1545 KTQLEELEDEL--QATEDAK----------LRLEVNMQALKGQ-FERDLQARDEQNEEKR 1591

Query: 1669 EELSQETQTRETNL 1682
             +L ++    ET L
Sbjct: 1592 RQLQRQLHEYETEL 1605



 Score =  132 bits (333), Expect = 3e-30
 Identities = 252/1197 (21%), Positives = 493/1197 (41%), Gaps = 229/1197 (19%)

Query: 610  LNSVKNKFSD-VQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGAL 668
            L   KN   + +Q    LY E  +  + L  + Q+ + ++   EA L +E          
Sbjct: 885  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---------- 934

Query: 669  QERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALT 728
            ++R  +LQ +R+++ +Q   +L L   L+  E A   LQ         + + + ++  + 
Sbjct: 935  EDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 729  DRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQ 788
            D+ + +  +  L E+ + D      + +    NL+  L++   S +      S++  +L+
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMI------SELEVRLK 1044

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             +++  QE++           L + L+    D+  Q                     +A 
Sbjct: 1045 KEEKSRQELEK----------LKRKLEGDASDFHEQ---------------------IAD 1073

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK--------KELSEDIRRTHDA 900
            LQ  I   +  LAK   E+ AA  +L  ++      L+K         +L ED+     A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 901  KQGSESPAQ-AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLE--RLEEK 957
            +  +E   +  G E EALK +LE+     A  Q EL A+R Q + +  +   E  R  E 
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHEA 1192

Query: 958  EVVEFYRD---------PQLEGSLSRVKAQVEEEG----KRRAGLQADLEVAAQKVVQLE 1004
            +V E  +           QLE    R KA +++      K  A L  +L V  Q   ++E
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251

Query: 1005 SKRKTMQPHL--LTKEVTQVERDPG-LDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
             K+K ++  +  L  + +  ER    L+ +  +L+ +++ + G       +   L K++ 
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311

Query: 1062 ALEKREVDVKEKVVVKEVVKVEKNL-----EMVKAAQALRLQMEEDAARRKQAEEAVAKL 1116
            +L  +  D +E  +++E  + + N+     ++ +   +L+ Q++E+   ++  E  ++ L
Sbjct: 1312 SLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 1117 QARIEDLERAI----SSVEP-----KVIVKEVK--------------KVEQDPGLLQES- 1152
              ++ D ++ +    S+VE      K   KE++              K+E+    LQ+  
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 1153 ----------SRLRSLLEEERTKNATLARELSDLHSKYS---------VVEKQRPKVQLQ 1193
                       +L S LE+++ K   L  E  ++ SKY+           EK+   + L 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 1194 ERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTV--EYK 1251
              + E  +   E E+    LKA+++++   +  V K V +L      L  Q   +  + +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 1252 EVTQEV-------VRHERSPEVLR-EIDR-LKAQLNELVNSHGRSQEQLIRLQGERDEWR 1302
            E+  E+       +R E + + L+ + +R L+A+  +      + Q QL   + E ++ R
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 1303 RERA-------KVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKR---------RA 1346
            ++RA       K+E      E+   + D  ++   E ++Q  +  AQ +         RA
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666

Query: 1347 AEDAVY------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVG 1400
            + D ++      E ++K L  +  + +E +   E    Q D +  E    L+ SL     
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 1401 ---RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQ 1457
                +R+LE  + QL   +EE++G +    DR +K   + E  QL+    EL     T Q
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE--QLS---NELATERSTAQ 1781

Query: 1458 EKIIMEEVVKLEKDPDLEKSTEALRWDLDQ------EKTQVTELNRECKNLQVQIDVLQK 1511
            +     +         LE+  + LR  L +       K + T    E K  Q++  V Q+
Sbjct: 1782 KNESARQ--------QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 1512 AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLG 1571
            A+  EK    + ++ QKD+ L++   +V +    ER   +  +E+A +   R+       
Sbjct: 1834 AR--EKQAATKSLK-QKDKKLKEILLQVED----ERKMAEQYKEQAEKGNARV------- 1879

Query: 1572 RTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKA 1631
                    +L+R  ++A++E  R+    R L+R+              L + TES     
Sbjct: 1880 -------KQLKRQLEEAEEESQRINANRRKLQRE--------------LDEATESNE--- 1915

Query: 1632 AQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLS-TKIS 1687
               G+E++ L++ + R  +  +   R         + +   +ET TR+ + + TK S
Sbjct: 1916 -AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKAS 1971



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 113/454 (24%), Positives = 218/454 (48%), Gaps = 62/454 (13%)

Query: 1265 EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV-ETKTVSKEVVRHEKD 1323
            +V R+ + ++A+ +EL  +  R Q    + + E  E  ++ +++ E K + +E ++ E +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
               E E  R+R      A K++  E+ ++E+       E R  EE+   Q++   +K  K
Sbjct: 902  LYAEAEEMRVR-----LAAKKQELEEILHEM-------EARLEEEEDRGQQLQAERK--K 947

Query: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQ-- 1441
            + ++   L   L+EE   R++L+LE     A +++ E  +   +D++ KL+ ER+L +  
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007

Query: 1442 ---LTLRIQELEKRPPTV------QEKIIMEEVVKLEKD----PDLEKSTEALRWDLDQE 1488
               LT  + E E++   +       E +I E  V+L+K+     +LEK    L  D    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 1489 KTQVTELNRECKNLQVQI----DVLQKAKSQ-EKTIYKEVIRVQKDRVLEDERARVWEML 1543
              Q+ +L  +   L++Q+    + LQ A ++ +  I ++   ++K R LE   + + E L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127

Query: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
            + ER AR   E++ R L E ++  +T          EL+   D         QQELRA +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKT----------ELEDTLDST-----ATQQELRA-K 1171

Query: 1604 RQKQQQTLQ--LQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRD 1661
            R+++   L+  L EE++    + +  RQK AQ  +EL+       R K  + + ++TL  
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 1662 LHAKVSRE-----ELSQETQTRETNLSTKISILE 1690
             +A ++ E     +  QE + ++  L  ++  L+
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 112/527 (21%), Positives = 249/527 (47%), Gaps = 43/527 (8%)

Query: 1191 QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEY 1250
            +L  +V  + QV  + E+E+   + +LQ+   ++   E E+++L      L  +K  ++ 
Sbjct: 836  RLFTKVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ- 893

Query: 1251 KEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310
            +++  E   +  + E+   +   K +L E+++      E   RL+ E D  R ++ + E 
Sbjct: 894  EQLQAETELYAEAEEMRVRLAAKKQELEEILH------EMEARLEEEED--RGQQLQAER 945

Query: 1311 KTVSKEVVRHEKDPVLEKEAER----LRQEVREAAQKRRAAEDAVYELQSKRLLLERRKP 1366
            K ++++++  E+  + E+EA R    L +   EA  K+   E  V + Q+ +L  ER+  
Sbjct: 946  KKMAQQMLDLEEQ-LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004

Query: 1367 EEKV------VVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQE 1420
            EE++      + +E    +   KL+ +H  +   L+  + +  +   E+++L+  +E   
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064

Query: 1421 GLLSFQEDRSKKLAVERELR-QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTE 1479
                F E  +   A   EL+ QL  + +EL+     + ++I  +    L+K  +LE    
Sbjct: 1065 S--DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHIS 1121

Query: 1480 ALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ--EKTIYKEVIRVQKDR-VLEDER 1536
             L+ DLD E+    +  ++ ++L  +++ L+       + T  ++ +R ++++ V   ++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 1537 ARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQ 1596
            A   E  + E   ++ R++ A+ + E  ++ E     + R ++ L + +   ++E   L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNKQTLEKENADLA 1237

Query: 1597 QELRALERQKQQ---QTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIY 1653
             ELR L + KQ+   +  +L+ + + L  K     +  A+   ++ +L+  +      + 
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297

Query: 1654 EKE----RTLRDLHAKVSR----EELSQETQTRETNLSTKISILEPE 1692
            E E    +  +D+ +  S+    +EL QE   ++ N+STK+  LE E
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 221/1171 (18%), Positives = 466/1171 (39%), Gaps = 205/1171 (17%)

Query: 12   KGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQAN----ADQVERDILETQKRLQQD 67
            K   +   A+   K    +HS+  T+E  LL  ++QA     A+  E  +    K+ + +
Sbjct: 863  KTKERQQKAENELKELEQKHSQL-TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921

Query: 68   RLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLH-ERV 126
             +  E    L+ +++ G+ L+     +    LD+++       Q EE E   ++L  E+V
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKV 974

Query: 127  TQECAEYRALYEKMVLPPDVGPRVDWARVL---------------EQKQKQVCA--GQYG 169
            T E A+ + L +++++  D   ++   R L               E+K K +     ++ 
Sbjct: 975  TAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 170  PGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLY 229
              ++ELE ++ +    ++E++   ++L      DA+    Q  DL    +     L    
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEG----DASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 230  THLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDD 289
              LQ    +L     Q+   L++     + +  G   + +     E  ++ ++  Q  D 
Sbjct: 1090 EELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 290  GERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTL 349
            GE +               EALK E ++ L+    Q+      E   + ++E   + + L
Sbjct: 1145 GEEL---------------EALKTELEDTLDSTATQQ------ELRAKREQEVTVLKKAL 1183

Query: 350  AKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR 409
             +   + +A+          A  EL +QLE  ++  A  ++    L++ + D+A      
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------ 1237

Query: 410  NPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPA 469
                             GE+++L G+  + V++             + K+  A    + +
Sbjct: 1238 -----------------GELRVL-GQAKQEVEH-------------KKKKLEAQVQELQS 1266

Query: 470  PDPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLT 529
               D     + L  ++  L+ ++ +V   L  +  ++++ ++   S S       Q+LL 
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DTQELLQ 1325

Query: 530  QMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE 589
            + TR   ++    RQ+         R +  + L+  + + +   + + +L  +   ++K+
Sbjct: 1326 EETRQKLNVSTKLRQLEE------ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 590  CEAFLSTRPVGPAALQLPVALNSVKNKFS-DVQVLCSLYGEKAKA--------------- 633
             + F ST            AL   K +F  +++ L   Y EKA A               
Sbjct: 1380 LQDFASTVE----------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 634  ---ALDLERQ---IQDADRVIRGFEATLVQEAPIP-----------AEPGALQERVSELQ 676
                +DL+ Q   + + ++  R F+  L +E  I            AE    + +   L 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 677  RQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGD 736
            R   E LE +  + R ++ LKA      + +++  +   +L + +R +    +      +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 737  QLDLREKVVQDAALTYQ--------QFKNCKDNLSSWLEHLPRSQVRP--------SDGP 780
            +L+   +  +DA L  +        QF+          E   R   R          D  
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 781  SQIAYKLQAQKRLTQEIQSRE-------RDRATASHLSQALQAALQDYELQADTYRCSLE 833
             Q A    A+K+L  +++  E       + R  A    + LQA ++D++ + +  R S +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM---LEKKEL 890
               A +     +   L+  +   +++LA A     A +Q  L++ E A ++   L  +  
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAA---ERARKQADLEKEELAEELASSLSGRNA 1726

Query: 891  SEDIRRTHDAK--QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS-------- 940
             +D +R  +A+  Q  E   +     EA+  ++ +  ++  ++ +EL  +RS        
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 941  -QLLQLRTQRPLERLEEKE--VVEFYRD--PQLEGSLSRVKAQVEEEGKRRAGLQADLEV 995
             Q L+ + +    +L E E  V   ++     LE  +++++ QVE+E + +      L+ 
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846

Query: 996  AAQK----VVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
              +K    ++Q+E +RK  + +   KE  Q E+    +++  QL+ Q+++   E   I+A
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQY---KE--QAEKG---NARVKQLKRQLEEAEEESQRINA 1898

Query: 1052 RLEGLKKEL-LALEKREVDVKEKVVVKEVVK 1081
                L++EL  A E  E   +E   +K  ++
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/225 (24%), Positives = 99/225 (44%), Gaps = 24/225 (10%)

Query: 1483 WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV-QKDRVLEDERARVWE 1541
            W L  +   + ++ R+ + +Q + D LQK K +++    E+  + QK   L +E+  + E
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 1542 MLNRE-RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
             L  E     +A E   R   ++ +  E L    +R E E  R             Q+L+
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG------------QQLQ 942

Query: 1601 ALERQKQQQTLQLQ---EESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKER 1657
            A  ++  QQ L L+   EE +   QK + E+  A  + ++L   E  ++ +++    KER
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED-EILVMDDQNNKLSKER 1001

Query: 1658 TL-----RDLHAKVSREELSQETQTRETNL-STKISILEPETGKD 1696
             L      DL   ++ EE   +  T+  N   + IS LE    K+
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  146 bits (369), Expect = 2e-34
 Identities = 198/854 (23%), Positives = 372/854 (43%), Gaps = 142/854 (16%)

Query: 878  LEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEA 937
            L+  R+  E +   +++++T + +Q +E+     +E E   +QL EE+  +   Q +L+A
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENEL---KELEQKHSQLTEEKNLL---QEQLQA 905

Query: 938  QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAA 997
            +     +    R   RL  K+        +LE  L  ++A++EEE  R   LQA+ +  A
Sbjct: 906  ETELYAEAEEMRV--RLAAKK-------QELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 998  QKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLK 1057
            Q+++ LE +   ++     ++  Q+E+             +I++L  E  V+  +   L 
Sbjct: 957  QQMLDLEEQ---LEEEEAARQKLQLEK--------VTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 1058 KELLALEKREVDV-----KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA 1112
            KE   LE+R  D+     +E+   K + K++   E + +   +RL+ EE +  R++ E+ 
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--RQELEKL 1063

Query: 1113 VAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARE 1172
              KL+    D    I+ ++ ++   +++                 L ++E    A LAR 
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQAALARL 1106

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
              ++  K + ++K R                 E E  I+ L+  L      R+  EK+  
Sbjct: 1107 DDEIAQKNNALKKIR-----------------ELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL-------REIDRLKAQLNELVNSHG 1285
             L  +LE L+ +         TQ+ +R +R  EV         E    +AQ+ E+   H 
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 1286 RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRR 1345
            ++ E+L     + ++++R +A ++    + E    +++  L  E   L Q  +E   K++
Sbjct: 1210 QAVEELTE---QLEQFKRAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKK 1262

Query: 1346 AAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQL 1405
              E  V ELQSK    ER + E         +  K  KL+ E   ++G L+E  G+  +L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAE---------LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313

Query: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKR-PPTVQEKIIMEE 1464
              +V  L + +++ + LL  QE+  +KL V  +LRQL      L+ +    ++ K  +E 
Sbjct: 1314 AKDVASLSSQLQDTQELL--QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 1465 VVKL---------EKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ 1515
             +           +K  D   + EAL     + + ++  L ++ +      D L+K K++
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 1516 -EKTIYKEVIRVQKDRVLE---DERARVWEML-------------NRERTARQAREEE-- 1556
             ++ +   V+ +   R L    +++ R ++ L              R+R   +ARE+E  
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1557 ----ARRLRERIDRAETLGRT---WSREESELQRARDQADQECGRLQQELRALERQKQQQ 1609
                AR L E ++  E L RT      E  +L  ++D   +    L++  RALE Q ++ 
Sbjct: 1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551

Query: 1610 TLQLQE-ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668
              QL+E E +L  Q TE  +           RLE  +   K Q +E++   RD   +  R
Sbjct: 1552 KTQLEELEDEL--QATEDAK----------LRLEVNMQALKGQ-FERDLQARDEQNEEKR 1598

Query: 1669 EELSQETQTRETNL 1682
             +L ++    ET L
Sbjct: 1599 RQLQRQLHEYETEL 1612



 Score =  132 bits (333), Expect = 3e-30
 Identities = 252/1197 (21%), Positives = 493/1197 (41%), Gaps = 229/1197 (19%)

Query: 610  LNSVKNKFSD-VQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGAL 668
            L   KN   + +Q    LY E  +  + L  + Q+ + ++   EA L +E          
Sbjct: 892  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---------- 941

Query: 669  QERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALT 728
            ++R  +LQ +R+++ +Q   +L L   L+  E A   LQ         + + + ++  + 
Sbjct: 942  EDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 729  DRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQ 788
            D+ + +  +  L E+ + D      + +    NL+  L++   S +      S++  +L+
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMI------SELEVRLK 1051

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             +++  QE++           L + L+    D+  Q                     +A 
Sbjct: 1052 KEEKSRQELEK----------LKRKLEGDASDFHEQ---------------------IAD 1080

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK--------KELSEDIRRTHDA 900
            LQ  I   +  LAK   E+ AA  +L  ++      L+K         +L ED+     A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 901  KQGSESPAQ-AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLE--RLEEK 957
            +  +E   +  G E EALK +LE+     A  Q EL A+R Q + +  +   E  R  E 
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHEA 1199

Query: 958  EVVEFYRD---------PQLEGSLSRVKAQVEEEG----KRRAGLQADLEVAAQKVVQLE 1004
            +V E  +           QLE    R KA +++      K  A L  +L V  Q   ++E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258

Query: 1005 SKRKTMQPHL--LTKEVTQVERDPG-LDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
             K+K ++  +  L  + +  ER    L+ +  +L+ +++ + G       +   L K++ 
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318

Query: 1062 ALEKREVDVKEKVVVKEVVKVEKNL-----EMVKAAQALRLQMEEDAARRKQAEEAVAKL 1116
            +L  +  D +E  +++E  + + N+     ++ +   +L+ Q++E+   ++  E  ++ L
Sbjct: 1319 SLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 1117 QARIEDLERAI----SSVEP-----KVIVKEVK--------------KVEQDPGLLQES- 1152
              ++ D ++ +    S+VE      K   KE++              K+E+    LQ+  
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 1153 ----------SRLRSLLEEERTKNATLARELSDLHSKYS---------VVEKQRPKVQLQ 1193
                       +L S LE+++ K   L  E  ++ SKY+           EK+   + L 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 1194 ERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTV--EYK 1251
              + E  +   E E+    LKA+++++   +  V K V +L      L  Q   +  + +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 1252 EVTQEV-------VRHERSPEVLR-EIDR-LKAQLNELVNSHGRSQEQLIRLQGERDEWR 1302
            E+  E+       +R E + + L+ + +R L+A+  +      + Q QL   + E ++ R
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 1303 RERA-------KVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKR---------RA 1346
            ++RA       K+E      E+   + D  ++   E ++Q  +  AQ +         RA
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673

Query: 1347 AEDAVY------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVG 1400
            + D ++      E ++K L  +  + +E +   E    Q D +  E    L+ SL     
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 1401 ---RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQ 1457
                +R+LE  + QL   +EE++G +    DR +K   + E  QL+    EL     T Q
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE--QLS---NELATERSTAQ 1788

Query: 1458 EKIIMEEVVKLEKDPDLEKSTEALRWDLDQ------EKTQVTELNRECKNLQVQIDVLQK 1511
            +     +         LE+  + LR  L +       K + T    E K  Q++  V Q+
Sbjct: 1789 KNESARQ--------QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1512 AKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLG 1571
            A+  EK    + ++ QKD+ L++   +V +    ER   +  +E+A +   R+       
Sbjct: 1841 AR--EKQAATKSLK-QKDKKLKEILLQVED----ERKMAEQYKEQAEKGNARV------- 1886

Query: 1572 RTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKA 1631
                    +L+R  ++A++E  R+    R L+R+              L + TES     
Sbjct: 1887 -------KQLKRQLEEAEEESQRINANRRKLQRE--------------LDEATESNE--- 1922

Query: 1632 AQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLS-TKIS 1687
               G+E++ L++ + R  +  +   R         + +   +ET TR+ + + TK S
Sbjct: 1923 -AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKAS 1978



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 113/454 (24%), Positives = 218/454 (48%), Gaps = 62/454 (13%)

Query: 1265 EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV-ETKTVSKEVVRHEKD 1323
            +V R+ + ++A+ +EL  +  R Q    + + E  E  ++ +++ E K + +E ++ E +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
               E E  R+R      A K++  E+ ++E+       E R  EE+   Q++   +K  K
Sbjct: 909  LYAEAEEMRVR-----LAAKKQELEEILHEM-------EARLEEEEDRGQQLQAERK--K 954

Query: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQ-- 1441
            + ++   L   L+EE   R++L+LE     A +++ E  +   +D++ KL+ ER+L +  
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 1442 ---LTLRIQELEKRPPTV------QEKIIMEEVVKLEKD----PDLEKSTEALRWDLDQE 1488
               LT  + E E++   +       E +I E  V+L+K+     +LEK    L  D    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 1489 KTQVTELNRECKNLQVQI----DVLQKAKSQ-EKTIYKEVIRVQKDRVLEDERARVWEML 1543
              Q+ +L  +   L++Q+    + LQ A ++ +  I ++   ++K R LE   + + E L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134

Query: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
            + ER AR   E++ R L E ++  +T          EL+   D         QQELRA +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKT----------ELEDTLDST-----ATQQELRA-K 1178

Query: 1604 RQKQQQTLQ--LQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRD 1661
            R+++   L+  L EE++    + +  RQK AQ  +EL+       R K  + + ++TL  
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 1662 LHAKVSRE-----ELSQETQTRETNLSTKISILE 1690
             +A ++ E     +  QE + ++  L  ++  L+
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 112/527 (21%), Positives = 249/527 (47%), Gaps = 43/527 (8%)

Query: 1191 QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEY 1250
            +L  +V  + QV  + E+E+   + +LQ+   ++   E E+++L      L  +K  ++ 
Sbjct: 843  RLFTKVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ- 900

Query: 1251 KEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310
            +++  E   +  + E+   +   K +L E+++      E   RL+ E D  R ++ + E 
Sbjct: 901  EQLQAETELYAEAEEMRVRLAAKKQELEEILH------EMEARLEEEED--RGQQLQAER 952

Query: 1311 KTVSKEVVRHEKDPVLEKEAER----LRQEVREAAQKRRAAEDAVYELQSKRLLLERRKP 1366
            K ++++++  E+  + E+EA R    L +   EA  K+   E  V + Q+ +L  ER+  
Sbjct: 953  KKMAQQMLDLEEQ-LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011

Query: 1367 EEKV------VVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQE 1420
            EE++      + +E    +   KL+ +H  +   L+  + +  +   E+++L+  +E   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071

Query: 1421 GLLSFQEDRSKKLAVERELR-QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTE 1479
                F E  +   A   EL+ QL  + +EL+     + ++I  +    L+K  +LE    
Sbjct: 1072 S--DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHIS 1128

Query: 1480 ALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ--EKTIYKEVIRVQKDR-VLEDER 1536
             L+ DLD E+    +  ++ ++L  +++ L+       + T  ++ +R ++++ V   ++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 1537 ARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQ 1596
            A   E  + E   ++ R++ A+ + E  ++ E     + R ++ L + +   ++E   L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNKQTLEKENADLA 1244

Query: 1597 QELRALERQKQQ---QTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIY 1653
             ELR L + KQ+   +  +L+ + + L  K     +  A+   ++ +L+  +      + 
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304

Query: 1654 EKE----RTLRDLHAKVSR----EELSQETQTRETNLSTKISILEPE 1692
            E E    +  +D+ +  S+    +EL QE   ++ N+STK+  LE E
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 221/1171 (18%), Positives = 466/1171 (39%), Gaps = 205/1171 (17%)

Query: 12   KGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQAN----ADQVERDILETQKRLQQD 67
            K   +   A+   K    +HS+  T+E  LL  ++QA     A+  E  +    K+ + +
Sbjct: 870  KTKERQQKAENELKELEQKHSQL-TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 928

Query: 68   RLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLH-ERV 126
             +  E    L+ +++ G+ L+     +    LD+++       Q EE E   ++L  E+V
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKV 981

Query: 127  TQECAEYRALYEKMVLPPDVGPRVDWARVL---------------EQKQKQVCA--GQYG 169
            T E A+ + L +++++  D   ++   R L               E+K K +     ++ 
Sbjct: 982  TAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 170  PGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLY 229
              ++ELE ++ +    ++E++   ++L      DA+    Q  DL    +     L    
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEG----DASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 230  THLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDD 289
              LQ    +L     Q+   L++     + +  G   + +     E  ++ ++  Q  D 
Sbjct: 1097 EELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 290  GERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTL 349
            GE +               EALK E ++ L+    Q+      E   + ++E   + + L
Sbjct: 1152 GEEL---------------EALKTELEDTLDSTATQQ------ELRAKREQEVTVLKKAL 1190

Query: 350  AKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR 409
             +   + +A+          A  EL +QLE  ++  A  ++    L++ + D+A      
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------ 1244

Query: 410  NPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPA 469
                             GE+++L G+  + V++             + K+  A    + +
Sbjct: 1245 -----------------GELRVL-GQAKQEVEH-------------KKKKLEAQVQELQS 1273

Query: 470  PDPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLT 529
               D     + L  ++  L+ ++ +V   L  +  ++++ ++   S S       Q+LL 
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DTQELLQ 1332

Query: 530  QMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE 589
            + TR   ++    RQ+         R +  + L+  + + +   + + +L  +   ++K+
Sbjct: 1333 EETRQKLNVSTKLRQLEE------ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 590  CEAFLSTRPVGPAALQLPVALNSVKNKFS-DVQVLCSLYGEKAKA--------------- 633
             + F ST            AL   K +F  +++ L   Y EKA A               
Sbjct: 1387 LQDFASTVE----------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 634  ---ALDLERQ---IQDADRVIRGFEATLVQEAPIP-----------AEPGALQERVSELQ 676
                +DL+ Q   + + ++  R F+  L +E  I            AE    + +   L 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 677  RQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGD 736
            R   E LE +  + R ++ LKA      + +++  +   +L + +R +    +      +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 737  QLDLREKVVQDAALTYQ--------QFKNCKDNLSSWLEHLPRSQVRP--------SDGP 780
            +L+   +  +DA L  +        QF+          E   R   R          D  
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 781  SQIAYKLQAQKRLTQEIQSRE-------RDRATASHLSQALQAALQDYELQADTYRCSLE 833
             Q A    A+K+L  +++  E       + R  A    + LQA ++D++ + +  R S +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM---LEKKEL 890
               A +     +   L+  +   +++LA A     A +Q  L++ E A ++   L  +  
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAA---ERARKQADLEKEELAEELASSLSGRNA 1733

Query: 891  SEDIRRTHDAK--QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS-------- 940
             +D +R  +A+  Q  E   +     EA+  ++ +  ++  ++ +EL  +RS        
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 941  -QLLQLRTQRPLERLEEKE--VVEFYRD--PQLEGSLSRVKAQVEEEGKRRAGLQADLEV 995
             Q L+ + +    +L E E  V   ++     LE  +++++ QVE+E + +      L+ 
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853

Query: 996  AAQK----VVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
              +K    ++Q+E +RK  + +   KE  Q E+    +++  QL+ Q+++   E   I+A
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQY---KE--QAEKG---NARVKQLKRQLEEAEEESQRINA 1905

Query: 1052 RLEGLKKEL-LALEKREVDVKEKVVVKEVVK 1081
                L++EL  A E  E   +E   +K  ++
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/225 (24%), Positives = 99/225 (44%), Gaps = 24/225 (10%)

Query: 1483 WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV-QKDRVLEDERARVWE 1541
            W L  +   + ++ R+ + +Q + D LQK K +++    E+  + QK   L +E+  + E
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 1542 MLNRE-RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
             L  E     +A E   R   ++ +  E L    +R E E  R             Q+L+
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG------------QQLQ 949

Query: 1601 ALERQKQQQTLQLQ---EESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKER 1657
            A  ++  QQ L L+   EE +   QK + E+  A  + ++L   E  ++ +++    KER
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED-EILVMDDQNNKLSKER 1008

Query: 1658 TL-----RDLHAKVSREELSQETQTRETNL-STKISILEPETGKD 1696
             L      DL   ++ EE   +  T+  N   + IS LE    K+
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  146 bits (369), Expect = 2e-34
 Identities = 198/854 (23%), Positives = 372/854 (43%), Gaps = 142/854 (16%)

Query: 878  LEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEA 937
            L+  R+  E +   +++++T + +Q +E+     +E E   +QL EE+  +   Q +L+A
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENEL---KELEQKHSQLTEEKNLL---QEQLQA 905

Query: 938  QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAA 997
            +     +    R   RL  K+        +LE  L  ++A++EEE  R   LQA+ +  A
Sbjct: 906  ETELYAEAEEMRV--RLAAKK-------QELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 998  QKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLK 1057
            Q+++ LE +   ++     ++  Q+E+             +I++L  E  V+  +   L 
Sbjct: 957  QQMLDLEEQ---LEEEEAARQKLQLEK--------VTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 1058 KELLALEKREVDV-----KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA 1112
            KE   LE+R  D+     +E+   K + K++   E + +   +RL+ EE +  R++ E+ 
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--RQELEKL 1063

Query: 1113 VAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARE 1172
              KL+    D    I+ ++ ++   +++                 L ++E    A LAR 
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQAALARL 1106

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
              ++  K + ++K R                 E E  I+ L+  L      R+  EK+  
Sbjct: 1107 DDEIAQKNNALKKIR-----------------ELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL-------REIDRLKAQLNELVNSHG 1285
             L  +LE L+ +         TQ+ +R +R  EV         E    +AQ+ E+   H 
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 1286 RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRR 1345
            ++ E+L     + ++++R +A ++    + E    +++  L  E   L Q  +E   K++
Sbjct: 1210 QAVEELTE---QLEQFKRAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKK 1262

Query: 1346 AAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQL 1405
              E  V ELQSK    ER + E         +  K  KL+ E   ++G L+E  G+  +L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAE---------LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313

Query: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKR-PPTVQEKIIMEE 1464
              +V  L + +++ + LL  QE+  +KL V  +LRQL      L+ +    ++ K  +E 
Sbjct: 1314 AKDVASLSSQLQDTQELL--QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 1465 VVKL---------EKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ 1515
             +           +K  D   + EAL     + + ++  L ++ +      D L+K K++
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 1516 -EKTIYKEVIRVQKDRVLE---DERARVWEML-------------NRERTARQAREEE-- 1556
             ++ +   V+ +   R L    +++ R ++ L              R+R   +ARE+E  
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1557 ----ARRLRERIDRAETLGRT---WSREESELQRARDQADQECGRLQQELRALERQKQQQ 1609
                AR L E ++  E L RT      E  +L  ++D   +    L++  RALE Q ++ 
Sbjct: 1492 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551

Query: 1610 TLQLQE-ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668
              QL+E E +L  Q TE  +           RLE  +   K Q +E++   RD   +  R
Sbjct: 1552 KTQLEELEDEL--QATEDAK----------LRLEVNMQALKGQ-FERDLQARDEQNEEKR 1598

Query: 1669 EELSQETQTRETNL 1682
             +L ++    ET L
Sbjct: 1599 RQLQRQLHEYETEL 1612



 Score =  142 bits (358), Expect = 3e-33
 Identities = 236/1079 (21%), Positives = 469/1079 (43%), Gaps = 149/1079 (13%)

Query: 674  ELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHA 733
            ++ RQ  E+  ++  + +     + +E+    L+    +  ++    Q Q++A T+ Y A
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-A 911

Query: 734  VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP-RSQVRPSDGPSQIAYKLQAQKR 792
              +++ +R       A   Q+ +     + + LE    R Q   ++        L  +++
Sbjct: 912  EAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 793  LTQEIQSRER---DRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPL 849
            L +E  +R++   ++ TA    +A    L+D  L  D     L     +      R++ L
Sbjct: 966  LEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERKLL---EERISDL 1018

Query: 850  QESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQ 909
              ++ A+E+  AK  T++    + ++ +LE   K  EK       +     K+  E  A 
Sbjct: 1019 TTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEGDAS 1072

Query: 910  AGRESEA-LKAQLEEERKRVARVQHELEAQRSQLLQLRTQR--PLERLEEKE--VVEFYR 964
               E  A L+AQ+ E + ++A+ + EL+A  ++L     Q+   L+++ E E  + +   
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 965  DPQLE-GSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVE 1023
            D   E  + ++ + Q  + G+    L+ +LE         +  R   +     +EVT ++
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QEVTVLK 1187

Query: 1024 RDPGLDSQAAQLRIQIQQLRGEDAV----ISARLEGLKKELLALEKREVDVKEKVVVKEV 1079
            +   LD +      Q+Q++R + A     ++ +LE  K+      K  +D  ++ + KE 
Sbjct: 1188 K--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-----KANLDKNKQTLEKE- 1239

Query: 1080 VKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEV 1139
                 N ++    + L    +E   ++K+ E  V +LQ++  D ERA + +  KV  K  
Sbjct: 1240 -----NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH-KLQ 1293

Query: 1140 KKVEQDPGLLQES-----------SRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRP 1188
             +VE   G+L E+           + L S L++ +       R+  ++ +K   +E++R 
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353

Query: 1189 KVQLQERVHEIFQVDPETEQEITRL-------KAKLQEMAGKRSGVEKEVEKLLPDLEVL 1241
               LQ+++ E  +     E+ I+ L       K KLQ+ A     +E+  ++   ++E L
Sbjct: 1354 S--LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 1242 RAQKPTVEYKEVTQEVVRHERSPEVLR-EIDRLKAQLN---ELVNSHGRSQEQLIRLQGE 1297
                 T +Y+E      + E++   L+ E+D L   L+   +LV++  + Q +  +L  E
Sbjct: 1412 -----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1298 -----------RDEWRRERAKVETKTVS-----KEVVRHEKDPVLEKEAERLRQEVREAA 1341
                       RD    E  + ETK +S     +E +  +++  LE+  + L+ E+ +  
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLV 1524

Query: 1342 QKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEV---VVTQKDPKLREEHSR--LSGSLD 1396
              +      V+EL+  +  LE +  E K  ++E+   +   +D KLR E +   L G  +
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

Query: 1397 EEVG--------RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQE 1448
             ++         +RRQL+ ++ +    +E++    +      KKL  E +L+ L L+   
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADS 1642

Query: 1449 LEK-RPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQID 1507
              K R   +++   ++  +K     D ++  E  R   D+      E  ++ K+L+  + 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 1508 VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRA 1567
             LQ+  +  +       R +K   LE E     E L    + R A ++E RRL  RI + 
Sbjct: 1698 QLQEDLAAAE-------RARKQADLEKEELA--EELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 1568 ETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESE 1627
            E        EE E ++   +A      +   +R   +Q +Q + +L  E +  +QK ES 
Sbjct: 1749 E--------EELEEEQGNMEA------MSDRVRKATQQAEQLSNELATE-RSTAQKNESA 1793

Query: 1628 RQKAAQRGQEL-SRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTK 1685
            RQ+  ++ +EL S+L       K +    + T+  L AK+++ E   E + RE   +TK
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATK 1849



 Score =  132 bits (332), Expect = 3e-30
 Identities = 240/1115 (21%), Positives = 467/1115 (41%), Gaps = 195/1115 (17%)

Query: 610  LNSVKNKFSD-VQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGAL 668
            L   KN   + +Q    LY E  +  + L  + Q+ + ++   EA L +E          
Sbjct: 892  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---------- 941

Query: 669  QERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALT 728
            ++R  +LQ +R+++ +Q   +L L   L+  E A   LQ         + + + ++  + 
Sbjct: 942  EDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 729  DRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQ 788
            D+ + +  +  L E+ + D      + +    NL+  L++   S +      S++  +L+
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMI------SELEVRLK 1051

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             +++  QE++           L + L+    D+  Q                     +A 
Sbjct: 1052 KEEKSRQELEK----------LKRKLEGDASDFHEQ---------------------IAD 1080

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK--------KELSEDIRRTHDA 900
            LQ  I   +  LAK   E+ AA  +L  ++      L+K         +L ED+     A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 901  KQGSESPAQ-AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLE--RLEEK 957
            +  +E   +  G E EALK +LE+     A  Q EL A+R Q + +  +   E  R  E 
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHEA 1199

Query: 958  EVVEFYRD---------PQLEGSLSRVKAQVEEEG----KRRAGLQADLEVAAQKVVQLE 1004
            +V E  +           QLE    R KA +++      K  A L  +L V  Q   ++E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258

Query: 1005 SKRKTMQPHL--LTKEVTQVERDPG-LDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
             K+K ++  +  L  + +  ER    L+ +  +L+ +++ + G       +   L K++ 
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318

Query: 1062 ALEKREVDVKEKVVVKEVVKVEKNL-----EMVKAAQALRLQMEEDAARRKQAEEAVAKL 1116
            +L  +  D +E  +++E  + + N+     ++ +   +L+ Q++E+   ++  E  ++ L
Sbjct: 1319 SLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 1117 QARIEDLERAI----SSVEP-----KVIVKEVK--------------KVEQDPGLLQES- 1152
              ++ D ++ +    S+VE      K   KE++              K+E+    LQ+  
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 1153 ----------SRLRSLLEEERTKNATLARELSDLHSKYS---------VVEKQRPKVQLQ 1193
                       +L S LE+++ K   L  E  ++ SKY+           EK+   + L 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 1194 ERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTV--EYK 1251
              + E  +   E E+    LKA+++++   +  V K V +L      L  Q   +  + +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 1252 EVTQEV-------VRHERSPEVLR-EIDR-LKAQLNELVNSHGRSQEQLIRLQGERDEWR 1302
            E+  E+       +R E + + L+ + +R L+A+  +      + Q QL   + E ++ R
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 1303 RERA-------KVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKR---------RA 1346
            ++RA       K+E      E+   + D  ++   E ++Q  +  AQ +         RA
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673

Query: 1347 AEDAVY------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVG 1400
            + D ++      E ++K L  +  + +E +   E    Q D +  E    L+ SL     
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 1401 ---RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQ 1457
                +R+LE  + QL   +EE++G +    DR +K   + E  QL+    EL     T Q
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE--QLS---NELATERSTAQ 1788

Query: 1458 EKIIMEEVVKLEKDPDLEKSTEALRWDLDQ------EKTQVTELNRECKNLQVQIDVLQK 1511
            +     +         LE+  + LR  L +       K + T    E K  Q++  V Q+
Sbjct: 1789 KNESARQ--------QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1512 AKSQEKTIYKEVIRVQKDRVLEDERARVW-EMLNRERTARQAREEEAR--RLRERIDRAE 1568
            A+  EK    + ++ QKD+ L++   +V  E    E+   QA +  AR  +L+ +++ AE
Sbjct: 1841 AR--EKQAATKSLK-QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897

Query: 1569 TLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
               +  +    +LQR  D+A +    + +E+ AL+
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALK 1932



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 113/454 (24%), Positives = 218/454 (48%), Gaps = 62/454 (13%)

Query: 1265 EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV-ETKTVSKEVVRHEKD 1323
            +V R+ + ++A+ +EL  +  R Q    + + E  E  ++ +++ E K + +E ++ E +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
               E E  R+R      A K++  E+ ++E+       E R  EE+   Q++   +K  K
Sbjct: 909  LYAEAEEMRVR-----LAAKKQELEEILHEM-------EARLEEEEDRGQQLQAERK--K 954

Query: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQ-- 1441
            + ++   L   L+EE   R++L+LE     A +++ E  +   +D++ KL+ ER+L +  
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 1442 ---LTLRIQELEKRPPTV------QEKIIMEEVVKLEKD----PDLEKSTEALRWDLDQE 1488
               LT  + E E++   +       E +I E  V+L+K+     +LEK    L  D    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 1489 KTQVTELNRECKNLQVQI----DVLQKAKSQ-EKTIYKEVIRVQKDRVLEDERARVWEML 1543
              Q+ +L  +   L++Q+    + LQ A ++ +  I ++   ++K R LE   + + E L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134

Query: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
            + ER AR   E++ R L E ++  +T          EL+   D         QQELRA +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKT----------ELEDTLDST-----ATQQELRA-K 1178

Query: 1604 RQKQQQTLQ--LQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRD 1661
            R+++   L+  L EE++    + +  RQK AQ  +EL+       R K  + + ++TL  
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 1662 LHAKVSRE-----ELSQETQTRETNLSTKISILE 1690
             +A ++ E     +  QE + ++  L  ++  L+
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 112/527 (21%), Positives = 249/527 (47%), Gaps = 43/527 (8%)

Query: 1191 QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEY 1250
            +L  +V  + QV  + E+E+   + +LQ+   ++   E E+++L      L  +K  ++ 
Sbjct: 843  RLFTKVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ- 900

Query: 1251 KEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310
            +++  E   +  + E+   +   K +L E+++      E   RL+ E D  R ++ + E 
Sbjct: 901  EQLQAETELYAEAEEMRVRLAAKKQELEEILH------EMEARLEEEED--RGQQLQAER 952

Query: 1311 KTVSKEVVRHEKDPVLEKEAER----LRQEVREAAQKRRAAEDAVYELQSKRLLLERRKP 1366
            K ++++++  E+  + E+EA R    L +   EA  K+   E  V + Q+ +L  ER+  
Sbjct: 953  KKMAQQMLDLEEQ-LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011

Query: 1367 EEKV------VVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQE 1420
            EE++      + +E    +   KL+ +H  +   L+  + +  +   E+++L+  +E   
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071

Query: 1421 GLLSFQEDRSKKLAVERELR-QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTE 1479
                F E  +   A   EL+ QL  + +EL+     + ++I  +    L+K  +LE    
Sbjct: 1072 S--DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHIS 1128

Query: 1480 ALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ--EKTIYKEVIRVQKDR-VLEDER 1536
             L+ DLD E+    +  ++ ++L  +++ L+       + T  ++ +R ++++ V   ++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 1537 ARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQ 1596
            A   E  + E   ++ R++ A+ + E  ++ E     + R ++ L + +   ++E   L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNKQTLEKENADLA 1244

Query: 1597 QELRALERQKQQ---QTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIY 1653
             ELR L + KQ+   +  +L+ + + L  K     +  A+   ++ +L+  +      + 
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304

Query: 1654 EKE----RTLRDLHAKVSR----EELSQETQTRETNLSTKISILEPE 1692
            E E    +  +D+ +  S+    +EL QE   ++ N+STK+  LE E
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 221/1171 (18%), Positives = 466/1171 (39%), Gaps = 205/1171 (17%)

Query: 12   KGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQAN----ADQVERDILETQKRLQQD 67
            K   +   A+   K    +HS+  T+E  LL  ++QA     A+  E  +    K+ + +
Sbjct: 870  KTKERQQKAENELKELEQKHSQL-TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 928

Query: 68   RLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLH-ERV 126
             +  E    L+ +++ G+ L+     +    LD+++       Q EE E   ++L  E+V
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKV 981

Query: 127  TQECAEYRALYEKMVLPPDVGPRVDWARVL---------------EQKQKQVCA--GQYG 169
            T E A+ + L +++++  D   ++   R L               E+K K +     ++ 
Sbjct: 982  TAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 170  PGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLY 229
              ++ELE ++ +    ++E++   ++L      DA+    Q  DL    +     L    
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEG----DASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 230  THLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDD 289
              LQ    +L     Q+   L++     + +  G   + +     E  ++ ++  Q  D 
Sbjct: 1097 EELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 290  GERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTL 349
            GE +               EALK E ++ L+    Q+      E   + ++E   + + L
Sbjct: 1152 GEEL---------------EALKTELEDTLDSTATQQ------ELRAKREQEVTVLKKAL 1190

Query: 350  AKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR 409
             +   + +A+          A  EL +QLE  ++  A  ++    L++ + D+A      
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------ 1244

Query: 410  NPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPA 469
                             GE+++L G+  + V++             + K+  A    + +
Sbjct: 1245 -----------------GELRVL-GQAKQEVEH-------------KKKKLEAQVQELQS 1273

Query: 470  PDPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLT 529
               D     + L  ++  L+ ++ +V   L  +  ++++ ++   S S       Q+LL 
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DTQELLQ 1332

Query: 530  QMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE 589
            + TR   ++    RQ+         R +  + L+  + + +   + + +L  +   ++K+
Sbjct: 1333 EETRQKLNVSTKLRQLEE------ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 590  CEAFLSTRPVGPAALQLPVALNSVKNKFS-DVQVLCSLYGEKAKA--------------- 633
             + F ST            AL   K +F  +++ L   Y EKA A               
Sbjct: 1387 LQDFASTVE----------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 634  ---ALDLERQ---IQDADRVIRGFEATLVQEAPIP-----------AEPGALQERVSELQ 676
                +DL+ Q   + + ++  R F+  L +E  I            AE    + +   L 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 677  RQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGD 736
            R   E LE +  + R ++ LKA      + +++  +   +L + +R +    +      +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 737  QLDLREKVVQDAALTYQ--------QFKNCKDNLSSWLEHLPRSQVRP--------SDGP 780
            +L+   +  +DA L  +        QF+          E   R   R          D  
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 781  SQIAYKLQAQKRLTQEIQSRE-------RDRATASHLSQALQAALQDYELQADTYRCSLE 833
             Q A    A+K+L  +++  E       + R  A    + LQA ++D++ + +  R S +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM---LEKKEL 890
               A +     +   L+  +   +++LA A     A +Q  L++ E A ++   L  +  
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAA---ERARKQADLEKEELAEELASSLSGRNA 1733

Query: 891  SEDIRRTHDAK--QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS-------- 940
             +D +R  +A+  Q  E   +     EA+  ++ +  ++  ++ +EL  +RS        
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 941  -QLLQLRTQRPLERLEEKE--VVEFYRD--PQLEGSLSRVKAQVEEEGKRRAGLQADLEV 995
             Q L+ + +    +L E E  V   ++     LE  +++++ QVE+E + +      L+ 
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853

Query: 996  AAQK----VVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
              +K    ++Q+E +RK  + +   KE  Q E+    +++  QL+ Q+++   E   I+A
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQY---KE--QAEKG---NARVKQLKRQLEEAEEESQRINA 1905

Query: 1052 RLEGLKKEL-LALEKREVDVKEKVVVKEVVK 1081
                L++EL  A E  E   +E   +K  ++
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/225 (24%), Positives = 99/225 (44%), Gaps = 24/225 (10%)

Query: 1483 WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV-QKDRVLEDERARVWE 1541
            W L  +   + ++ R+ + +Q + D LQK K +++    E+  + QK   L +E+  + E
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 1542 MLNRE-RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
             L  E     +A E   R   ++ +  E L    +R E E  R             Q+L+
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG------------QQLQ 949

Query: 1601 ALERQKQQQTLQLQ---EESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKER 1657
            A  ++  QQ L L+   EE +   QK + E+  A  + ++L   E  ++ +++    KER
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED-EILVMDDQNNKLSKER 1008

Query: 1658 TL-----RDLHAKVSREELSQETQTRETNL-STKISILEPETGKD 1696
             L      DL   ++ EE   +  T+  N   + IS LE    K+
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  146 bits (369), Expect = 2e-34
 Identities = 198/854 (23%), Positives = 372/854 (43%), Gaps = 142/854 (16%)

Query: 878  LEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEA 937
            L+  R+  E +   +++++T + +Q +E+     +E E   +QL EE+  +   Q +L+A
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENEL---KELEQKHSQLTEEKNLL---QEQLQA 898

Query: 938  QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAA 997
            +     +    R   RL  K+        +LE  L  ++A++EEE  R   LQA+ +  A
Sbjct: 899  ETELYAEAEEMRV--RLAAKK-------QELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 998  QKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLK 1057
            Q+++ LE +   ++     ++  Q+E+             +I++L  E  V+  +   L 
Sbjct: 950  QQMLDLEEQ---LEEEEAARQKLQLEK--------VTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 1058 KELLALEKREVDV-----KEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA 1112
            KE   LE+R  D+     +E+   K + K++   E + +   +RL+ EE +  R++ E+ 
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS--RQELEKL 1056

Query: 1113 VAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARE 1172
              KL+    D    I+ ++ ++   +++                 L ++E    A LAR 
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQAALARL 1099

Query: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
              ++  K + ++K R                 E E  I+ L+  L      R+  EK+  
Sbjct: 1100 DDEIAQKNNALKKIR-----------------ELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL-------REIDRLKAQLNELVNSHG 1285
             L  +LE L+ +         TQ+ +R +R  EV         E    +AQ+ E+   H 
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 1286 RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRR 1345
            ++ E+L     + ++++R +A ++    + E    +++  L  E   L Q  +E   K++
Sbjct: 1203 QAVEELTE---QLEQFKRAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKK 1255

Query: 1346 AAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQL 1405
              E  V ELQSK    ER + E         +  K  KL+ E   ++G L+E  G+  +L
Sbjct: 1256 KLEAQVQELQSKCSDGERARAE---------LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306

Query: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKR-PPTVQEKIIMEE 1464
              +V  L + +++ + LL  QE+  +KL V  +LRQL      L+ +    ++ K  +E 
Sbjct: 1307 AKDVASLSSQLQDTQELL--QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 1465 VVKL---------EKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ 1515
             +           +K  D   + EAL     + + ++  L ++ +      D L+K K++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 1516 -EKTIYKEVIRVQKDRVLE---DERARVWEML-------------NRERTARQAREEE-- 1556
             ++ +   V+ +   R L    +++ R ++ L              R+R   +ARE+E  
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1557 ----ARRLRERIDRAETLGRT---WSREESELQRARDQADQECGRLQQELRALERQKQQQ 1609
                AR L E ++  E L RT      E  +L  ++D   +    L++  RALE Q ++ 
Sbjct: 1485 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544

Query: 1610 TLQLQE-ESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668
              QL+E E +L  Q TE  +           RLE  +   K Q +E++   RD   +  R
Sbjct: 1545 KTQLEELEDEL--QATEDAK----------LRLEVNMQALKGQ-FERDLQARDEQNEEKR 1591

Query: 1669 EELSQETQTRETNL 1682
             +L ++    ET L
Sbjct: 1592 RQLQRQLHEYETEL 1605



 Score =  142 bits (358), Expect = 3e-33
 Identities = 236/1079 (21%), Positives = 469/1079 (43%), Gaps = 149/1079 (13%)

Query: 674  ELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHA 733
            ++ RQ  E+  ++  + +     + +E+    L+    +  ++    Q Q++A T+ Y A
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-A 904

Query: 734  VGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLP-RSQVRPSDGPSQIAYKLQAQKR 792
              +++ +R       A   Q+ +     + + LE    R Q   ++        L  +++
Sbjct: 905  EAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 793  LTQEIQSRER---DRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPL 849
            L +E  +R++   ++ TA    +A    L+D  L  D     L     +      R++ L
Sbjct: 959  LEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERKLL---EERISDL 1011

Query: 850  QESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQ 909
              ++ A+E+  AK  T++    + ++ +LE   K  EK       +     K+  E  A 
Sbjct: 1012 TTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEGDAS 1065

Query: 910  AGRESEA-LKAQLEEERKRVARVQHELEAQRSQLLQLRTQR--PLERLEEKE--VVEFYR 964
               E  A L+AQ+ E + ++A+ + EL+A  ++L     Q+   L+++ E E  + +   
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 965  DPQLE-GSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVE 1023
            D   E  + ++ + Q  + G+    L+ +LE         +  R   +     +EVT ++
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QEVTVLK 1180

Query: 1024 RDPGLDSQAAQLRIQIQQLRGEDAV----ISARLEGLKKELLALEKREVDVKEKVVVKEV 1079
            +   LD +      Q+Q++R + A     ++ +LE  K+      K  +D  ++ + KE 
Sbjct: 1181 K--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-----KANLDKNKQTLEKE- 1232

Query: 1080 VKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEV 1139
                 N ++    + L    +E   ++K+ E  V +LQ++  D ERA + +  KV  K  
Sbjct: 1233 -----NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH-KLQ 1286

Query: 1140 KKVEQDPGLLQES-----------SRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRP 1188
             +VE   G+L E+           + L S L++ +       R+  ++ +K   +E++R 
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346

Query: 1189 KVQLQERVHEIFQVDPETEQEITRL-------KAKLQEMAGKRSGVEKEVEKLLPDLEVL 1241
               LQ+++ E  +     E+ I+ L       K KLQ+ A     +E+  ++   ++E L
Sbjct: 1347 S--LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 1242 RAQKPTVEYKEVTQEVVRHERSPEVLR-EIDRLKAQLN---ELVNSHGRSQEQLIRLQGE 1297
                 T +Y+E      + E++   L+ E+D L   L+   +LV++  + Q +  +L  E
Sbjct: 1405 -----TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1298 -----------RDEWRRERAKVETKTVS-----KEVVRHEKDPVLEKEAERLRQEVREAA 1341
                       RD    E  + ETK +S     +E +  +++  LE+  + L+ E+ +  
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLV 1517

Query: 1342 QKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEV---VVTQKDPKLREEHSR--LSGSLD 1396
              +      V+EL+  +  LE +  E K  ++E+   +   +D KLR E +   L G  +
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577

Query: 1397 EEVG--------RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQE 1448
             ++         +RRQL+ ++ +    +E++    +      KKL  E +L+ L L+   
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADS 1635

Query: 1449 LEK-RPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQID 1507
              K R   +++   ++  +K     D ++  E  R   D+      E  ++ K+L+  + 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 1508 VLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRA 1567
             LQ+  +  +       R +K   LE E     E L    + R A ++E RRL  RI + 
Sbjct: 1691 QLQEDLAAAE-------RARKQADLEKEELA--EELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 1568 ETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLSQKTESE 1627
            E        EE E ++   +A      +   +R   +Q +Q + +L  E +  +QK ES 
Sbjct: 1742 E--------EELEEEQGNMEA------MSDRVRKATQQAEQLSNELATE-RSTAQKNESA 1786

Query: 1628 RQKAAQRGQEL-SRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTK 1685
            RQ+  ++ +EL S+L       K +    + T+  L AK+++ E   E + RE   +TK
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATK 1842



 Score =  132 bits (332), Expect = 3e-30
 Identities = 240/1115 (21%), Positives = 467/1115 (41%), Gaps = 195/1115 (17%)

Query: 610  LNSVKNKFSD-VQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGAL 668
            L   KN   + +Q    LY E  +  + L  + Q+ + ++   EA L +E          
Sbjct: 885  LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE---------- 934

Query: 669  QERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALT 728
            ++R  +LQ +R+++ +Q   +L L   L+  E A   LQ         + + + ++  + 
Sbjct: 935  EDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 729  DRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQ 788
            D+ + +  +  L E+ + D      + +    NL+  L++   S +      S++  +L+
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMI------SELEVRLK 1044

Query: 789  AQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP 848
             +++  QE++           L + L+    D+  Q                     +A 
Sbjct: 1045 KEEKSRQELEK----------LKRKLEGDASDFHEQ---------------------IAD 1073

Query: 849  LQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEK--------KELSEDIRRTHDA 900
            LQ  I   +  LAK   E+ AA  +L  ++      L+K         +L ED+     A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 901  KQGSESPAQ-AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLE--RLEEK 957
            +  +E   +  G E EALK +LE+     A  Q EL A+R Q + +  +   E  R  E 
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHEA 1192

Query: 958  EVVEFYRD---------PQLEGSLSRVKAQVEEEG----KRRAGLQADLEVAAQKVVQLE 1004
            +V E  +           QLE    R KA +++      K  A L  +L V  Q   ++E
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251

Query: 1005 SKRKTMQPHL--LTKEVTQVERDPG-LDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
             K+K ++  +  L  + +  ER    L+ +  +L+ +++ + G       +   L K++ 
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311

Query: 1062 ALEKREVDVKEKVVVKEVVKVEKNL-----EMVKAAQALRLQMEEDAARRKQAEEAVAKL 1116
            +L  +  D +E  +++E  + + N+     ++ +   +L+ Q++E+   ++  E  ++ L
Sbjct: 1312 SLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 1117 QARIEDLERAI----SSVEP-----KVIVKEVK--------------KVEQDPGLLQES- 1152
              ++ D ++ +    S+VE      K   KE++              K+E+    LQ+  
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 1153 ----------SRLRSLLEEERTKNATLARELSDLHSKYS---------VVEKQRPKVQLQ 1193
                       +L S LE+++ K   L  E  ++ SKY+           EK+   + L 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 1194 ERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTV--EYK 1251
              + E  +   E E+    LKA+++++   +  V K V +L      L  Q   +  + +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 1252 EVTQEV-------VRHERSPEVLR-EIDR-LKAQLNELVNSHGRSQEQLIRLQGERDEWR 1302
            E+  E+       +R E + + L+ + +R L+A+  +      + Q QL   + E ++ R
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 1303 RERA-------KVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKR---------RA 1346
            ++RA       K+E      E+   + D  ++   E ++Q  +  AQ +         RA
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666

Query: 1347 AEDAVY------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVG 1400
            + D ++      E ++K L  +  + +E +   E    Q D +  E    L+ SL     
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 1401 ---RRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQ 1457
                +R+LE  + QL   +EE++G +    DR +K   + E  QL+    EL     T Q
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE--QLS---NELATERSTAQ 1781

Query: 1458 EKIIMEEVVKLEKDPDLEKSTEALRWDLDQ------EKTQVTELNRECKNLQVQIDVLQK 1511
            +     +         LE+  + LR  L +       K + T    E K  Q++  V Q+
Sbjct: 1782 KNESARQ--------QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 1512 AKSQEKTIYKEVIRVQKDRVLEDERARVW-EMLNRERTARQAREEEAR--RLRERIDRAE 1568
            A+  EK    + ++ QKD+ L++   +V  E    E+   QA +  AR  +L+ +++ AE
Sbjct: 1834 AR--EKQAATKSLK-QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890

Query: 1569 TLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
               +  +    +LQR  D+A +    + +E+ AL+
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALK 1925



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 113/454 (24%), Positives = 218/454 (48%), Gaps = 62/454 (13%)

Query: 1265 EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV-ETKTVSKEVVRHEKD 1323
            +V R+ + ++A+ +EL  +  R Q    + + E  E  ++ +++ E K + +E ++ E +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
               E E  R+R      A K++  E+ ++E+       E R  EE+   Q++   +K  K
Sbjct: 902  LYAEAEEMRVR-----LAAKKQELEEILHEM-------EARLEEEEDRGQQLQAERK--K 947

Query: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQ-- 1441
            + ++   L   L+EE   R++L+LE     A +++ E  +   +D++ KL+ ER+L +  
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007

Query: 1442 ---LTLRIQELEKRPPTV------QEKIIMEEVVKLEKD----PDLEKSTEALRWDLDQE 1488
               LT  + E E++   +       E +I E  V+L+K+     +LEK    L  D    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 1489 KTQVTELNRECKNLQVQI----DVLQKAKSQ-EKTIYKEVIRVQKDRVLEDERARVWEML 1543
              Q+ +L  +   L++Q+    + LQ A ++ +  I ++   ++K R LE   + + E L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127

Query: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
            + ER AR   E++ R L E ++  +T          EL+   D         QQELRA +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKT----------ELEDTLDST-----ATQQELRA-K 1171

Query: 1604 RQKQQQTLQ--LQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRD 1661
            R+++   L+  L EE++    + +  RQK AQ  +EL+       R K  + + ++TL  
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 1662 LHAKVSRE-----ELSQETQTRETNLSTKISILE 1690
             +A ++ E     +  QE + ++  L  ++  L+
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 112/527 (21%), Positives = 249/527 (47%), Gaps = 43/527 (8%)

Query: 1191 QLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEY 1250
            +L  +V  + QV  + E+E+   + +LQ+   ++   E E+++L      L  +K  ++ 
Sbjct: 836  RLFTKVKPLLQVTRQ-EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ- 893

Query: 1251 KEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310
            +++  E   +  + E+   +   K +L E+++      E   RL+ E D  R ++ + E 
Sbjct: 894  EQLQAETELYAEAEEMRVRLAAKKQELEEILH------EMEARLEEEED--RGQQLQAER 945

Query: 1311 KTVSKEVVRHEKDPVLEKEAER----LRQEVREAAQKRRAAEDAVYELQSKRLLLERRKP 1366
            K ++++++  E+  + E+EA R    L +   EA  K+   E  V + Q+ +L  ER+  
Sbjct: 946  KKMAQQMLDLEEQ-LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004

Query: 1367 EEKV------VVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQE 1420
            EE++      + +E    +   KL+ +H  +   L+  + +  +   E+++L+  +E   
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064

Query: 1421 GLLSFQEDRSKKLAVERELR-QLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTE 1479
                F E  +   A   EL+ QL  + +EL+     + ++I  +    L+K  +LE    
Sbjct: 1065 S--DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHIS 1121

Query: 1480 ALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQ--EKTIYKEVIRVQKDR-VLEDER 1536
             L+ DLD E+    +  ++ ++L  +++ L+       + T  ++ +R ++++ V   ++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 1537 ARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQ 1596
            A   E  + E   ++ R++ A+ + E  ++ E     + R ++ L + +   ++E   L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNKQTLEKENADLA 1237

Query: 1597 QELRALERQKQQ---QTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIY 1653
             ELR L + KQ+   +  +L+ + + L  K     +  A+   ++ +L+  +      + 
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297

Query: 1654 EKE----RTLRDLHAKVSR----EELSQETQTRETNLSTKISILEPE 1692
            E E    +  +D+ +  S+    +EL QE   ++ N+STK+  LE E
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 221/1171 (18%), Positives = 466/1171 (39%), Gaps = 205/1171 (17%)

Query: 12   KGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQAN----ADQVERDILETQKRLQQD 67
            K   +   A+   K    +HS+  T+E  LL  ++QA     A+  E  +    K+ + +
Sbjct: 863  KTKERQQKAENELKELEQKHSQL-TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921

Query: 68   RLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLH-ERV 126
             +  E    L+ +++ G+ L+     +    LD+++       Q EE E   ++L  E+V
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKV 974

Query: 127  TQECAEYRALYEKMVLPPDVGPRVDWARVL---------------EQKQKQVCA--GQYG 169
            T E A+ + L +++++  D   ++   R L               E+K K +     ++ 
Sbjct: 975  TAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 170  PGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLY 229
              ++ELE ++ +    ++E++   ++L      DA+    Q  DL    +     L    
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEG----DASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 230  THLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDD 289
              LQ    +L     Q+   L++     + +  G   + +     E  ++ ++  Q  D 
Sbjct: 1090 EELQAALARLDDEIAQKNNALKK-----IRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 290  GERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTL 349
            GE +               EALK E ++ L+    Q+      E   + ++E   + + L
Sbjct: 1145 GEEL---------------EALKTELEDTLDSTATQQ------ELRAKREQEVTVLKKAL 1183

Query: 350  AKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR 409
             +   + +A+          A  EL +QLE  ++  A  ++    L++ + D+A      
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------ 1237

Query: 410  NPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPA 469
                             GE+++L G+  + V++             + K+  A    + +
Sbjct: 1238 -----------------GELRVL-GQAKQEVEH-------------KKKKLEAQVQELQS 1266

Query: 470  PDPDAVARASRLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLT 529
               D     + L  ++  L+ ++ +V   L  +  ++++ ++   S S       Q+LL 
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ-DTQELLQ 1325

Query: 530  QMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKE 589
            + TR   ++    RQ+         R +  + L+  + + +   + + +L  +   ++K+
Sbjct: 1326 EETRQKLNVSTKLRQLEE------ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 590  CEAFLSTRPVGPAALQLPVALNSVKNKFS-DVQVLCSLYGEKAKA--------------- 633
             + F ST            AL   K +F  +++ L   Y EKA A               
Sbjct: 1380 LQDFASTVE----------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 634  ---ALDLERQ---IQDADRVIRGFEATLVQEAPIP-----------AEPGALQERVSELQ 676
                +DL+ Q   + + ++  R F+  L +E  I            AE    + +   L 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 677  RQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGD 736
            R   E LE +  + R ++ LKA      + +++  +   +L + +R +    +      +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 737  QLDLREKVVQDAALTYQ--------QFKNCKDNLSSWLEHLPRSQVRP--------SDGP 780
            +L+   +  +DA L  +        QF+          E   R   R          D  
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 781  SQIAYKLQAQKRLTQEIQSRE-------RDRATASHLSQALQAALQDYELQADTYRCSLE 833
             Q A    A+K+L  +++  E       + R  A    + LQA ++D++ + +  R S +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM---LEKKEL 890
               A +     +   L+  +   +++LA A     A +Q  L++ E A ++   L  +  
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAA---ERARKQADLEKEELAEELASSLSGRNA 1726

Query: 891  SEDIRRTHDAK--QGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRS-------- 940
             +D +R  +A+  Q  E   +     EA+  ++ +  ++  ++ +EL  +RS        
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 941  -QLLQLRTQRPLERLEEKE--VVEFYRD--PQLEGSLSRVKAQVEEEGKRRAGLQADLEV 995
             Q L+ + +    +L E E  V   ++     LE  +++++ QVE+E + +      L+ 
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846

Query: 996  AAQK----VVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISA 1051
              +K    ++Q+E +RK  + +   KE  Q E+    +++  QL+ Q+++   E   I+A
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQY---KE--QAEKG---NARVKQLKRQLEEAEEESQRINA 1898

Query: 1052 RLEGLKKEL-LALEKREVDVKEKVVVKEVVK 1081
                L++EL  A E  E   +E   +K  ++
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/225 (24%), Positives = 99/225 (44%), Gaps = 24/225 (10%)

Query: 1483 WDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV-QKDRVLEDERARVWE 1541
            W L  +   + ++ R+ + +Q + D LQK K +++    E+  + QK   L +E+  + E
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 1542 MLNRE-RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
             L  E     +A E   R   ++ +  E L    +R E E  R             Q+L+
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG------------QQLQ 942

Query: 1601 ALERQKQQQTLQLQ---EESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKER 1657
            A  ++  QQ L L+   EE +   QK + E+  A  + ++L   E  ++ +++    KER
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED-EILVMDDQNNKLSKER 1001

Query: 1658 TL-----RDLHAKVSREELSQETQTRETNL-STKISILEPETGKD 1696
             L      DL   ++ EE   +  T+  N   + IS LE    K+
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  144 bits (362), Expect = 1e-33
 Identities = 388/1842 (21%), Positives = 731/1842 (39%), Gaps = 292/1842 (15%)

Query: 55   RDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEE 114
            +++++ + R  +  L++E+SQA Q +    R L +AE           + +     Q   
Sbjct: 801  KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE----------QEGKTALEQQKAA 850

Query: 115  IEKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQKQVCAGQYGPGMAE 174
             EK++ QL E+  +E + ++    K  L      +++    L+++Q ++ A Q      E
Sbjct: 851  HEKEVNQLREKWEKERSWHQQELAK-ALESLEREKMELEMRLKEQQTEMEAIQ---AQRE 906

Query: 175  LEQQIAEHNILQKEIDAYGQQLRSLVG--------PDAATIRSQYRDLLKAASWRGQ-SL 225
             E+  AE  + Q +++   +++  L           DA+    + R  +K    + Q + 
Sbjct: 907  EERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966

Query: 226  GSLYTHLQGCTRQLSALAEQQR---RILQQDWSDLMADPAGVRREYEHFKQHELLSQEQS 282
            G L T LQ   R+L   A Q R     LQ++ S L+ D   ++++ E  K  +L++Q+ S
Sbjct: 967  GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS-QLVAQDDS 1025

Query: 283  VNQLEDD-GERMVELRHPAVGPIQAHQE--------ALKMEWQNFLNLCICQETQLQHVE 333
               +E +  E++ E +      IQ   E        +L  + Q  L L      + Q + 
Sbjct: 1026 QRLVEQEVQEKLRETQE--YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083

Query: 334  DYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAE---EKRLAVT-- 388
              R+  +EA    + L+     L  +             +LL++LEA    E++L  +  
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLW 1143

Query: 389  --ERATGDLQRRSR----DVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQG---ERYKL 439
              E     LQ R R     +  L   + P  Q      +    S   Q L      R +L
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203

Query: 440  VDNTD--PHAWVVQ----GPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKL- 492
                D  P  W ++    G     KR P                A  +AS L  L Q L 
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLL----------TALSAEAVASALHKLHQDLW 1253

Query: 493  ATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAP 552
             T Q+R                   D+   Q QKL  ++T  + +  Q+  ++    R  
Sbjct: 1254 KTQQTR-------------------DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294

Query: 553  LSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNS 612
                      EG+ +S E     L       ++  +  E  L           L  A  +
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE--LQRMEAQGERELLQAAKEN 1352

Query: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672
            +  +   +Q        +A AA  LE  ++ A   ++     +  E        ALQE+ 
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER---ERAQALQEQ- 1408

Query: 673  SELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYH 732
             EL+  + + L++   +L   + L   E     L+   QE  +    Q+  +  L+    
Sbjct: 1409 GELKVAQGKALQENLALLT--QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466

Query: 733  AVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKR 792
                ++DL+++ +       Q+ + C+    S LEHLP +         +   KL  Q+ 
Sbjct: 1467 KRNQEVDLQQEQI-------QELEKCR----SVLEHLPMA-------VQEREQKLTVQR- 1507

Query: 793  LTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQES 852
              ++I+  E+DR T  ++ +     L+  +   ++ R  ++               L+E+
Sbjct: 1508 --EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN 1565

Query: 853  IQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGR 912
                E             QQ+L+++LE  R+       ++ +  TH              
Sbjct: 1566 HHKME------------CQQKLIKELEGQRE-------TQRVALTH-------------- 1592

Query: 913  ESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSL 972
                L   LEE          EL+AQ SQ+  L +   +   E +E     RD +++   
Sbjct: 1593 ----LTLDLEER-------SQELQAQSSQIHDLESHSTVLARELQE-----RDQEVKSQ- 1635

Query: 973  SRVKAQVEEEGKRRAGLQADLEVAAQKV------VQLESKRKTMQPHLLTKEVTQV---- 1022
               + Q+EE  +++  L  DLE   Q++      +Q+   ++T Q  +L +++ Q+    
Sbjct: 1636 ---REQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692

Query: 1023 -ERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVK-EKVVVKEVV 1080
             ER   L +Q   ++ + ++ +G        LE +K   L L  +E +V+ ++  + E+ 
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK---LILRDKEKEVECQQEHIHELQ 1749

Query: 1081 KVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVK 1140
            +++  LE  +  Q L  ++ E +    Q E+ +  LQ ++++                  
Sbjct: 1750 ELKDQLE--QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE------------------ 1789

Query: 1141 KVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIF 1200
               ++ G L+E S L+S L+E +   A   +EL  L  +    + Q      +ERV E  
Sbjct: 1790 --AREQGELKEQS-LQSQLDEAQRALAQRDQELEALQQEQQQAQGQ------EERVKE-- 1838

Query: 1201 QVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRH 1260
            + D   +  + +    L+E  G+    +++  +L  +L V   +   +E  EV  ++   
Sbjct: 1839 KAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE--EVLGDLRAE 1895

Query: 1261 ERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH 1320
             R  E  + +  L+ Q  E      ++QE  +  +  +D W + +A ++ +    E +R 
Sbjct: 1896 SREQE--KALLALQQQCAE------QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947

Query: 1321 EKDPVL-EKEAERLRQE-VREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVT 1378
            E      ++EA R R E ++EA  K  AA      LQ K   L  +    + +       
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAA------LQGKEQHLLEQAELSRSLEASTATL 2001

Query: 1379 QKDPKLREEHSR-LSGSLDEEVGRRRQLEL----EVQQLRAGVEEQEGLLSFQEDRSKKL 1433
            Q      + HSR L  +L  + G  +  +L    +VQQL+  + +++  L  Q++R + L
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061

Query: 1434 AVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVT 1493
              E+ L Q   R+QE       +QEK  + +  + E+   L +S   L+  L Q++ ++ 
Sbjct: 2062 --EKSLAQ---RVQE-----NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEIL 2111

Query: 1494 EL--NRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQ 1551
            EL   ++  NL+      + +  +E+++  + +  +  R LE  +A + +   RE   R+
Sbjct: 2112 ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171

Query: 1552 AREEEARRLRERIDRAETLGRTWSREESE--LQRARDQADQECGRLQQEL----RALERQ 1605
              ++ A  L      A+T     S +E    LQ +  + D E  RLQ EL    RALE++
Sbjct: 2172 KAQDLALSL------AQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225

Query: 1606 ---------------KQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKD 1650
                           + +Q +QL E S + ++ +    +K + R Q L  L+ A+ R + 
Sbjct: 2226 RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR-QRLEHLQQAVARLEI 2284

Query: 1651 QIYEKERTLRDLHAKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDR 1710
                 +R    L + + + E  +    RE   + +   LE       SP +   RG    
Sbjct: 2285 DRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG---- 2340

Query: 1711 GQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGH 1770
                +  + +C   E+       +  + L+RK  + Y   +A   R ++   +H      
Sbjct: 2341 ---QKNSDAKC-VAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELA-GLHHSLSHSL 2395

Query: 1771 LPISEF--ALLVAGETKPSSSLSIGSIISKSP-LASPAPQST 1809
            L +++   A ++  ET+        S+ S  P L  P+P +T
Sbjct: 2396 LAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTT 2437



 Score =  122 bits (307), Expect = 3e-27
 Identities = 241/1109 (21%), Positives = 460/1109 (41%), Gaps = 159/1109 (14%)

Query: 674  ELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHA 733
            E ++QR E L +    LRLH  ++ ++    AL+ + ++   D  R + ++     ++  
Sbjct: 104  EEEQQRCESLAEVNTQLRLH--MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQM 161

Query: 734  V------------GDQLDLREKVVQDAALTYQQ-FKNCKDNLSSWLEHLPRSQVRPSDGP 780
                         G  L L  +VV     T+++ F   K      L  L    VR S   
Sbjct: 162  EQEFFKGYLKGEHGRLLSLWREVV-----TFRRHFLEMKSATDRDLMELKAEHVRLSGS- 215

Query: 781  SQIAYKLQAQKRLTQEIQSRERD---RATASHLSQALQAALQDYELQADTYRCSLEPTLA 837
                  L    RLT   QSRE +   R      +Q L    +  EL+ + +  S E    
Sbjct: 216  -----LLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQE---- 266

Query: 838  VSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRT 897
                    +  L+     ++  L    TE++A   Q  +Q E   KM++    + +I  T
Sbjct: 267  --------LIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILET 318

Query: 898  HDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEK 957
            +  +   E  A   R ++  K  L++  K + +V  E   +   + Q         L+  
Sbjct: 319  NHTEL-MEHEASLSRNAQEEKLSLQQVIKDITQVMVE---EGDNIAQGSGHENSLELDSS 374

Query: 958  EVVEF-YRDPQ-----LEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQ 1011
               +F Y+D       +   L+R +  V++  ++ AG Q  + +  Q+  Q E + K ++
Sbjct: 375  IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434

Query: 1012 PHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEK-----R 1066
              L   +    ERD  L  Q   L+ ++  L  E  ++    E L+++L  LE+     R
Sbjct: 435  QRL---QKLTGERDT-LAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490

Query: 1067 EVDVKEKVV------VKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQA-R 1119
             V+V+ ++        KE  + E +L + +  +   + M  +A + +   E +   +A  
Sbjct: 491  RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550

Query: 1120 IEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSR--------LRSLLEEERTKNATLAR 1171
               LE  +   E   +   + + EQ    L  S          LR+   +    N  LA 
Sbjct: 551  SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610

Query: 1172 ELSDLHSKYSVVEKQRPKV----QLQERVHEIFQVD-PETEQEITRLKAKLQEMAGKRSG 1226
            +   L+ +   +E++   V    +  E+     QVD  E E+    L  K   +  +   
Sbjct: 611  DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670

Query: 1227 VEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGR 1286
             E+   +L  DL  ++ +K  ++ K++++   RH++        +    QL +L     R
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQ-KKLSES--RHQQ--------EAATTQLEQLHQEAKR 719

Query: 1287 SQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRA 1346
             +E L R   E++   RE+A +E +  +           +E++ + L ++++  +  +  
Sbjct: 720  QEEVLARAVQEKEALVREKAALEVRLQA-----------VERDRQDLAEQLQGLSSAKEL 768

Query: 1347 AEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLE 1406
             E +++E Q +  ++E  K + +V +Q   VTQ    ++ E   L   LD E  +  Q E
Sbjct: 769  LESSLFEAQQQNSVIEVTKGQLEVQIQ--TVTQAKEVIQGEVRCLKLELDTERSQAEQ-E 825

Query: 1407 LEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVV 1466
             +    +    EQEG  + ++   +K A E+E+ QL    ++ EK     Q+        
Sbjct: 826  RDAAARQLAQAEQEGKTALEQ---QKAAHEKEVNQLR---EKWEKERSWHQQ-------- 871

Query: 1467 KLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRV 1526
                  +L K+ E+L    ++EK    EL    K  Q +++ +Q  + +E+T  +  +  
Sbjct: 872  ------ELAKALESL----EREKM---ELEMRLKEQQTEMEAIQAQREEERTQAESAL-C 917

Query: 1527 QKDRVLEDERARVWEMLNRERTARQAREEEARRLRE-----RIDRAETLG--RTWSRE-E 1578
            Q     E ER  + E L + +       ++  RLR+     ++   ET G  +T  +E +
Sbjct: 918  QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977

Query: 1579 SELQRARDQADQECGRLQQELRALERQKQQQTLQLQE-ESKLLSQK-----TESERQKAA 1632
             EL+ A  Q   +   LQ+E  +L + K     Q+++ +S+L++Q       E E Q+  
Sbjct: 978  RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037

Query: 1633 QRGQELSRLEAAILREKD----QIYEKERTLRDLHA--KVSREELS------QETQTRET 1680
            +  QE +R++  + REK      + EKE+ L  L     + ++ELS      QE Q  + 
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097

Query: 1681 NLSTKISILEPETGKDMSPYEAYKRGIID 1709
             LS ++ +L  E  +  + + A +  +++
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLE 1126



 Score =  117 bits (294), Expect = 9e-26
 Identities = 236/1108 (21%), Positives = 447/1108 (40%), Gaps = 141/1108 (12%)

Query: 629  EKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTC 688
            E+ KA     +++      + G    L  E    ++   L ++  E  RQ+ E+LEQ+  
Sbjct: 428  EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAW 487

Query: 689  VL-RLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQD 747
             L R++  L+    +    +   QE      R++ +++ +     A   +  L E +   
Sbjct: 488  RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-SLSELITLR 546

Query: 748  AALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATA 807
             AL                 HL    +R            Q Q  +T  +   E+  A  
Sbjct: 547  EALE--------------SSHLEGELLR------------QEQTEVTAALARAEQSIAEL 580

Query: 808  SHLSQALQAALQDYELQADTYRCS-LEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTE 866
            S     L+  + D  L+A   + S L   LA+      +V   Q+ +Q +E+N +     
Sbjct: 581  SSSENTLKTEVAD--LRAAAVKLSALNEALALD-----KVGLNQQLLQLEEENQSVCSRM 633

Query: 867  VAAAQQQLLQQLEFARKMLEKKELSEDIRRTH---DAKQGSESPAQAGRESEALKAQLEE 923
             AA Q +   Q++ A     ++ L E  + TH     ++  E+ A+   +   ++ + EE
Sbjct: 634  EAAEQARNALQVDLAEAEKRREALWE--KNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691

Query: 924  ERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEG 983
             +K+++  +H+ EA  +QL QL      E   ++EV+   R  Q + +L R KA +E   
Sbjct: 692  IQKKLSESRHQQEAATTQLEQLHQ----EAKRQEEVLA--RAVQEKEALVREKAALE--- 742

Query: 984  KRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLR 1043
             R   ++ D +  A+++  L S ++ ++  L   +    +++  ++    QL +QIQ + 
Sbjct: 743  VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ----QQNSVIEVTKGQLEVQIQTVT 798

Query: 1044 GEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDA 1103
                VI   +  LK E L  E+ + + +     +++ + E+  +     Q    + E + 
Sbjct: 799  QAKEVIQGEVRCLKLE-LDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857

Query: 1104 ARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEER 1163
             R K  +E     Q    +L +A+ S+E + +  E++  EQ      E   +++  EEER
Sbjct: 858  LREKWEKERSWHQQ----ELAKALESLEREKMELEMRLKEQQ----TEMEAIQAQREEER 909

Query: 1164 T--KNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMA 1221
            T  ++A    +L     + S++E     +Q Q+ + +  Q      Q++   K K QE  
Sbjct: 910  TQAESALCQMQLETEKERVSLLE---TLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966

Query: 1222 GKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQL---- 1277
            G      +E ++ L   E  R  +  +   +     +  ++  ++ ++++ LK+QL    
Sbjct: 967  GILQTQLQEAQRELK--EAARQHRDDLAALQEESSSLLQDKM-DLQKQVEDLKSQLVAQD 1023

Query: 1278 ------NELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKE---VVRHEKDPVLEK 1328
                   + V    R  ++  R+Q E +   RE+A +    + KE   +V  E D + ++
Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELE---REKASLTLSLMEKEQRLLVLQEADSIRQQ 1080

Query: 1329 EAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEH 1388
            E   LRQ+++EA       E      Q + L  E ++ E   + QE  + ++        
Sbjct: 1081 ELSALRQDMQEA-----QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135

Query: 1389 SRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQE 1448
             +L  SL  +  +  QL+L ++      E Q   L+ ++    +   + +L  L   +Q+
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLR----STESQLEALAAEQQPGNQAQAQAQLASLYSALQQ 1191

Query: 1449 -----LEKRPPTVQEKIIMEEVVKLEKDPDLEK------------STEALRWDL-----D 1486
                  E RP           V  LE D +  +            S EA+   L     D
Sbjct: 1192 ALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251

Query: 1487 QEKTQVTE--LNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWE-ML 1543
              KTQ T   L  + + L+ ++   +  KSQ   ++ E+  +Q+      E    WE   
Sbjct: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ---VHTELQDLQRQLSQNQEEKSKWEGKQ 1308

Query: 1544 NRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALE 1603
            N   +      E    L+ R+ RAE        E   LQ A++    +   LQ  +  +E
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAV--VE 1366

Query: 1604 RQKQQQTLQLQEES--------KLLSQKTESERQK--AAQRGQELSRLEAAILREK---- 1649
             + Q     + EE         KL +++ ESER++  A Q   EL   +   L+E     
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426

Query: 1650 -DQIYEKERTLRDLHAKVSREELSQETQ 1676
               + E+E  +  L  ++   E  +E Q
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQ 1454


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  141 bits (356), Expect = 6e-33
 Identities = 256/1182 (21%), Positives = 484/1182 (40%), Gaps = 156/1182 (13%)

Query: 477  RASRLASELQALKQKLATV---QSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTR 533
            + +R   ELQA  ++L  V   Q++++    E  R  QQ     ++   Q Q      T 
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA----ETE 901

Query: 534  LDGDLGQIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAF 593
            L  +  ++ R  LA  +  L     L DLE R+   E   Q LQ+   + +   ++ E  
Sbjct: 902  LFAEAEEM-RARLAAKKQELEEI--LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958

Query: 594  LSTRPVGPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEA 653
            L         LQL       K K  + ++L     E   +    E+++ + DR+     +
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKMEEEILLL---EDQNSKFIKEKKLME-DRIAE-CSS 1013

Query: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
             L +E          +E+   L + R +   Q+  +  L   LK  E     L+   ++ 
Sbjct: 1014 QLAEE----------EEKAKNLAKIRNK---QEVMISDLEERLKKEEKTRQELEKAKRKL 1060

Query: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQ 773
              +    Q Q+  L  +   +  QL  +E+ +Q A          K+N    +  L    
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ--- 1117

Query: 774  VRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLE 833
                   +QIA   + Q+    E  SR +       LS+ L+A   + E   DT     E
Sbjct: 1118 -------AQIA---ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167

Query: 834  PTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEV----AAAQQQLLQQLEFARKMLEKKE 889
                +   +   VA L+++++ + KN      ++    A A ++L +QLE A++     E
Sbjct: 1168 ----LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223

Query: 890  LSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQR 949
             ++    T + +   E      +  + +KA+ E +RK++     EL A+ S+  +LR + 
Sbjct: 1224 KNKQGLETDNKELACEV-----KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE- 1277

Query: 950  PLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKT 1009
                L EK         +L+  L  V   +EE  K+  G++      A+    LES+ + 
Sbjct: 1278 ----LAEKA-------SKLQNELDNVSTLLEEAEKK--GIKF-----AKDAASLESQLQD 1319

Query: 1010 MQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVD 1069
             Q  LL +E  Q      L S+  QL  +   L+ +        + L+K++LAL+ +  D
Sbjct: 1320 TQ-ELLQEETRQ---KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD 1375

Query: 1070 VKEKV-----VVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLE 1124
             K+KV      ++ + + +K L  +K A+AL  ++EE A    + E+   +LQ  ++DL 
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKL--LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433

Query: 1125 RAISSVEPKVIVKEVKKVEQDPGLLQESS----------RLRSLLEEERTKNATLARELS 1174
              +          E K+ + D  L +E S          R  +   E+ TK  +LAR L 
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493

Query: 1175 DLHSKYSVVEKQRPKVQLQ------------ERVHEIFQVDPETEQEITRLKAKLQEMAG 1222
            +        E+Q  +++              + VHE+ +     EQ++  ++ +L+E+  
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553

Query: 1223 KRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQLNE--- 1279
            +    E    +L  +++ ++AQ    E    T++    E+   +++++  L+A+L +   
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQ---FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610

Query: 1280 ----LVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQ 1335
                 V S  + +  L  L+ + +   + R +V  +    +    +    LE EA   R 
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE-EARASRD 1669

Query: 1336 EV----REAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRL 1391
            E+    +E+ +K ++ E  + +LQ +    ER +   +         Q+  +L +E +  
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE---------QERDELADEITNS 1720

Query: 1392 SGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKK-----------LAVERELR 1440
            +      +  +R+LE  + QL   +EE++  +    DR +K           LA ER   
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780

Query: 1441 QLTLRI-QELEKRPPTVQEKI-IMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRE 1498
            Q +    Q+LE++   ++ K+  +E  VK +     + +  AL   + Q + Q   L +E
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSK----FKATISALEAKIGQLEEQ---LEQE 1833

Query: 1499 CKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEAR 1558
             K       ++++ + + K I+   ++V+ +R   D+     E  N      + + EEA 
Sbjct: 1834 AKERAAANKLVRRTEKKLKEIF---MQVEDERRHADQYKEQMEKANARMKQLKRQLEEA- 1889

Query: 1559 RLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELR 1600
               E   RA    R   RE  +   A +   +E   L+  LR
Sbjct: 1890 --EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score =  128 bits (321), Expect = 6e-29
 Identities = 186/836 (22%), Positives = 371/836 (44%), Gaps = 121/836 (14%)

Query: 909  QAGRESEALKAQLEE---ERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRD 965
            Q  R+ E L+A+ EE    +++  +V+ ELE    +  QL  ++ +  L E+   E    
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI--LAEQLQAETELF 903

Query: 966  PQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERD 1025
             + E   +R+ A+ +E  +    L++ +E   ++   L++++K MQ H+   E  Q++ +
Sbjct: 904  AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE-EQLDEE 962

Query: 1026 PGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKN 1085
             G     A+ ++Q++++  E     A+++ +++E+L LE +           + +K +K 
Sbjct: 963  EG-----ARQKLQLEKVTAE-----AKIKKMEEEILLLEDQN---------SKFIKEKKL 1003

Query: 1086 LEMVKAAQALRLQMEEDAAR-----RKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVK 1140
            +E   A  + +L  EE+ A+     R + E  ++ L+ R++  E+    +E     K  +
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE-----KAKR 1058

Query: 1141 KVEQDPGLLQES-SRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHE- 1198
            K++ +   LQ+  + L++ ++E + + A    EL    ++              E +H+ 
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD-----------DETLHKN 1107

Query: 1199 -IFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEV 1257
               +V  E + +I  L+   +     R+  EK+   L  +LE L+ +          Q+ 
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167

Query: 1258 VRHERSPEVLR-------EIDRLKAQLNELVNSHGRSQEQLIRL--QGERDEWRRERAKV 1308
            +R +R  EV         E    +AQ+ ++   H  + E+L     Q +R +   E+ K 
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227

Query: 1309 ETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEE 1368
              +T +KE         L  E + L+Q   E+  KR+  +  V EL +K    +R + E 
Sbjct: 1228 GLETDNKE---------LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE- 1277

Query: 1369 KVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQED 1428
                    + +K  KL+ E   +S  L+E   +  +   +   L + +++ + LL  QE+
Sbjct: 1278 --------LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--QEE 1327

Query: 1429 RSKKLAVERELRQLTLRIQELEKRPPTVQE--KIIMEEVVKLEK---------DPDLE-- 1475
              +KL +   +RQL      L+++    +E  K + ++V+ L+          D DL   
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387

Query: 1476 -----------KSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVI 1524
                       K  EAL   L+++     +L +    LQ ++D L      ++ +   + 
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447

Query: 1525 RVQK--DRVLEDER---ARVWEMLNRERTARQAREEE------ARRLRERIDRAETLGRT 1573
            + QK  D++L +E+   AR  E   R+R   +ARE+E      AR L E ++  E   R 
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAE--ERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505

Query: 1574 WSR---EESELQRARDQADQECGRLQQELRALERQKQQQTLQLQE-ESKLLSQKTESERQ 1629
              +   +  +L  ++D   +    L++  RALE+Q ++   QL+E E +L  Q TE  + 
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL--QATEDAKL 1563

Query: 1630 KAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETNLSTK 1685
            +     Q +       L+ +D+  E+++ L     +    EL  E + R   +++K
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 117/491 (23%), Positives = 237/491 (48%), Gaps = 80/491 (16%)

Query: 1265 EVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV-ETKTVSKEVVRHEKD 1323
            +V R+ + L+A+  EL+    + +E+  +++GE +E  R+  ++ E K +  E ++ E +
Sbjct: 846  QVTRQEEELQAKDEELL----KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901

Query: 1324 PVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
              L  EAE +R  +   A K++  E+ +++L+S+         EE+    +++  +K  K
Sbjct: 902  --LFAEAEEMRARL---AAKKQELEEILHDLESR--------VEEEEERNQILQNEKK-K 947

Query: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVEREL---- 1439
            ++     L   LDEE G R++L+LE     A +++ E  +   ED++ K   E++L    
Sbjct: 948  MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007

Query: 1440 -RQLTLRIQELEKRPPTV------QEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKT-- 1490
              + + ++ E E++   +      QE +I +   +L+K+    +  E  +  LD E T  
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067

Query: 1491 --QVTELNRECKNLQVQIDVLQK------AKSQEKTIYK-EVIRVQKDRVLEDERARVWE 1541
              Q+ EL  +   L++Q+   ++      A+  ++T++K   ++V ++  L+ + A + E
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE--LQAQIAELQE 1125

Query: 1542 MLNRERTARQAREEEARRLRERIDR-----AETLGRTWSREESELQRARDQADQECGRLQ 1596
                E+ +R   E++ R L E ++       +TL  T +++E   +R ++ A+ +   L+
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALE 1184

Query: 1597 QELRALERQ----KQQQTLQLQEESKLLSQ------KTESERQKAAQRGQELSRLEAAIL 1646
            +E +  E Q    +Q+    L+E S+ L Q        E  +Q      +EL+  E  +L
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA-CEVKVL 1243

Query: 1647 REKDQIYEKER-----TLRDLHAKVS-----REELSQETQTRETNLSTKISILEPETGKD 1696
            ++     E +R      +++LHAKVS     R EL+++    +  L    ++LE      
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE------ 1297

Query: 1697 MSPYEAYKRGI 1707
                EA K+GI
Sbjct: 1298 ----EAEKKGI 1304



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 235/1206 (19%), Positives = 470/1206 (38%), Gaps = 199/1206 (16%)

Query: 34   AATQELALLISRMQANADQVER--DILETQKRLQQ-------DRLNSEQS--QALQHQQE 82
            A  QEL  ++  +++  ++ E    IL+ +K+  Q       ++L+ E+   Q LQ ++ 
Sbjct: 915  AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974

Query: 83   TG----RSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYE 138
            T     + ++E  +LL+D      K ++L   +  E    + +  E+  +  A+ R   E
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA-KNLAKIRNKQE 1033

Query: 139  KMVLPPDVGPRV---DWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQ 195
             M+   D+  R+   +  R   +K K+   G+      +L+ QIAE   LQ +ID    Q
Sbjct: 1034 VMI--SDLEERLKKEEKTRQELEKAKRKLDGE----TTDLQDQIAE---LQAQIDELKLQ 1084

Query: 196  LRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWS 255
            L            ++  + L+ A  RG        +     R+L A   +    LQ+D+ 
Sbjct: 1085 L------------AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE----LQEDFE 1128

Query: 256  DLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEW 315
               A      ++     + EL + +  +    D      ELR      +   ++AL+ E 
Sbjct: 1129 SEKASRNKAEKQKRDLSE-ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187

Query: 316  QNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELL 375
            +N  +    Q+ + +H        E+ +   +  A L  N                    
Sbjct: 1188 KN--HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK------------------- 1226

Query: 376  QQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGE 435
            Q LE + K LA   +    LQ+   +     ++ +   Q LH   + + D   V+L + +
Sbjct: 1227 QGLETDNKELACEVKV---LQQVKAESEHKRKKLDAQVQELHA-KVSEGDRLRVELAE-K 1281

Query: 436  RYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATV 495
              KL +  D  + +++                     +A  +  + A +  +L+ +L   
Sbjct: 1282 ASKLQNELDNVSTLLE---------------------EAEKKGIKFAKDAASLESQLQDT 1320

Query: 496  QSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSR 555
            Q  L+    + L  S +     +  N     L  Q    +     +E+QVLA        
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKN----SLQEQQEEEEEARKNLEKQVLALQ------ 1370

Query: 556  PTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAAL--QLPVALNSV 613
             + L D + ++    GT   ++SL   K+   K+ EA LS R    A    +L    N +
Sbjct: 1371 -SQLADTKKKVDDDLGT---IESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRL 1425

Query: 614  KNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVI---RGFEATLVQEAP-IPAEPGALQ 669
            + +  D+ V       + + A +LE++ +  D+++   +   A   +E     AE    +
Sbjct: 1426 QQELDDLTVDLD---HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482

Query: 670  ERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTD 729
             +   L R   E LE +    R ++ L+A      + +++  +   +L + +R +    +
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542

Query: 730  RYHAVGDQLDLREKVVQDAALTYQ--------QFKN---CKDNLSSWLEHLPRSQVRP-- 776
                  ++L+   +  +DA L  +        QF+     +D  +   + L   QVR   
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602

Query: 777  ---SDGPSQIAYKLQAQKR-------LTQEIQSRERDRATASHLSQALQAALQDYELQAD 826
                D   Q A  + ++K+       L  +I++  + R       + LQA ++DY+ + +
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662

Query: 827  TYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLE 886
              R S +   A S     ++  L+  I   ++ LA +      A+Q             E
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ-------------E 1709

Query: 887  KKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERK---RVARVQHELEAQRSQLL 943
            + EL+++I  +   K                 A L+E+R+   R+A+++ ELE ++S   
Sbjct: 1710 RDELADEITNSASGK----------------SALLDEKRRLEARIAQLEEELEEEQSN-- 1751

Query: 944  QLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQL 1003
                   +E L ++      +   L   L+  ++  ++    R  L+   +    K+ +L
Sbjct: 1752 -------MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804

Query: 1004 ESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLAL 1063
            E   K+     ++           L+++  QL  Q++Q   E A  +  +   +K+L   
Sbjct: 1805 EGAVKSKFKATIS----------ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL--- 1851

Query: 1064 EKREVDVKEKVVVKEVVKVEKNLEMVKA-AQALRLQMEEDAARRKQAEEAVAKLQARIED 1122
              +E+ ++ +   +   + ++ +E   A  + L+ Q+EE      +A  +  KLQ  ++D
Sbjct: 1852 --KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909

Query: 1123 LERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSV 1182
               A   +  +  V  +K   +  G +  SS  RS   +   + A+L     D  SK S 
Sbjct: 1910 ATEANEGLSRE--VSTLKNRLRRGGPISFSSS-RSGRRQLHLEGASLELSDDDTESKTSD 1966

Query: 1183 VEKQRP 1188
            V + +P
Sbjct: 1967 VNETQP 1972


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,801,941
Number of Sequences: 37866
Number of extensions: 3571975
Number of successful extensions: 39286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 1262
Number of HSP's that attempted gapping in prelim test: 16464
Number of HSP's gapped (non-prelim): 10317
length of query: 2033
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1915
effective length of database: 13,779,330
effective search space: 26387416950
effective search space used: 26387416950
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.