Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 154759283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154759283 cerebellar degeneration-related protein 2-like
[Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154759283 cerebellar degeneration-related protein 2-like [Hom... 912 0.0
gi|55770832 cerebellar degeneration-related protein 2 [Homo sapi... 336 2e-92
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 64 3e-10
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 63 6e-10
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 60 4e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 56 6e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 56 6e-08
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 56 8e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 55 1e-07
gi|31982906 cingulin-like 1 [Homo sapiens] 54 2e-07
gi|45505178 cancer antigen 1 [Homo sapiens] 53 5e-07
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 53 5e-07
gi|93102364 SWAP-70 protein [Homo sapiens] 53 7e-07
gi|58530840 desmoplakin isoform I [Homo sapiens] 52 9e-07
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 52 9e-07
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 52 1e-06
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 52 1e-06
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 52 1e-06
gi|221139761 zinc finger protein 853 [Homo sapiens] 52 1e-06
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 52 1e-06
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 51 3e-06
gi|148746195 trichohyalin [Homo sapiens] 51 3e-06
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 51 3e-06
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 50 3e-06
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 50 3e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 50 4e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 50 6e-06
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 50 6e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 50 6e-06
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 49 7e-06
>gi|154759283 cerebellar degeneration-related protein 2-like [Homo
sapiens]
Length = 465
Score = 912 bits (2356), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV 60
MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV
Sbjct: 1 MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV 60
Query: 61 QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE 120
QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE
Sbjct: 61 QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE 120
Query: 121 RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS 180
RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS
Sbjct: 121 RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS 180
Query: 181 LELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEAC 240
LELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEAC
Sbjct: 181 LELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEAC 240
Query: 241 RLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQD 300
RLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQD
Sbjct: 241 RLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQD 300
Query: 301 GVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY 360
GVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY
Sbjct: 301 GVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY 360
Query: 361 HALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQ 420
HALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQ
Sbjct: 361 HALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQ 420
Query: 421 HVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK 465
HVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK
Sbjct: 421 HVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK 465
>gi|55770832 cerebellar degeneration-related protein 2 [Homo
sapiens]
Length = 454
Score = 336 bits (862), Expect = 2e-92
Identities = 204/461 (44%), Positives = 286/461 (62%), Gaps = 22/461 (4%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYL 66
+E+F +E+E WYD QDL+QDL LAAELGKTLL+RN ELE S+QQMY+TN+EQ+QEIEYL
Sbjct: 7 VEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQLQEIEYL 66
Query: 67 TKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQV 126
TKQ++ LR +NEQHAKVYEQLD+TAR+LE TN +LV +SKA+QQKI LTETIE LQ +
Sbjct: 67 TKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVADSKASQQKILSLTETIECLQTNI 126
Query: 127 EELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPR---CKDAFRLHSSSLEL 183
+ LQ+QVE+L+ Q R K ++ + +F CLKEL + F +SL+
Sbjct: 127 DHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFACLKELYDLRQHFVYDHVFAEKITSLQG 186
Query: 184 GPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLR 243
P P E+ENE L+ V L++Q+S ERQ++ E EY VL+E SELE+QL A R R
Sbjct: 187 QPSPDEEENEHLKKTVTMLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGATGAYRAR 246
Query: 244 VQELEAELLELQQMKQAK-TYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGV 302
ELEAE+ E++QM Q++ ++ G + + ++L P + ++ ++
Sbjct: 247 ALELEAEVAEMRQMLQSEHPFVNGVEKLVPDSLYVPFKEPSQS-----------LLEEMF 295
Query: 303 SSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHA 362
+ S +++S S+T L+++ D H A +V++RG+S+L EVD QY A
Sbjct: 296 LTVPESHRKPLKRSSSETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSA 355
Query: 363 LLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHV 422
L KYEELL KC++ + H VQTSR ++ +DL G V +G + S +
Sbjct: 356 LKVKYEELLKKCQEEQDSLSHKAVQTSR-----AAAKDLTGVNAQSEPVASGWELASVNP 410
Query: 423 EAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHS 463
E V + PEYKALFKEIFS I+KTK +I+ + K S
Sbjct: 411 EPVSS--PTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYRS 449
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 63.9 bits (154), Expect = 3e-10
Identities = 85/314 (27%), Positives = 137/314 (43%), Gaps = 44/314 (14%)
Query: 14 EEESWYDQQDLEQDLH-LAAELGKTLLER----NKELEGSLQQMYSTNEEQVQEIEYLTK 68
E+ S+ +Q + + H L AE + L ER + LE L Q E+ VQE+ +
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ---AREKYVQELAAVRA 1485
Query: 69 QLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEE 128
+T + A+V + TAR+LE V+ +K K+ L E +R Q + ++
Sbjct: 1486 DAET------RLAEVQREAQSTARELE------VMTAKYEGAKVKVLEER-QRFQEERQK 1532
Query: 129 LQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPL 188
L AQVEQL E +R +T K+L S + + +++
Sbjct: 1533 LTAQVEQL----------EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGES 1582
Query: 189 EQENERLQTLVGALRSQVSQERQ-------RKERAEREYTAVLQEYSELERQLCEMEACR 241
+QE +RLQ + L++Q+SQ+ Q + E+A+ Y A Q+ EL+ QL +E +
Sbjct: 1583 QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 242 LRVQELEAELLEL-QQMKQAKTYLLGPDD---HLAEALLAPLTQAPEADDPQPGRGDDLG 297
+EL AE L +++QA + HL + + Q AD G
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702
Query: 298 AQDGVSS--PAASP 309
A D + S P A P
Sbjct: 1703 ATDALKSREPQAKP 1716
Score = 57.0 bits (136), Expect = 4e-08
Identities = 75/277 (27%), Positives = 122/277 (44%), Gaps = 45/277 (16%)
Query: 12 AEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLD 71
AE++E+ +QD Q L AAE + L +E + +L+Q+ + +E+ ++E L +QL
Sbjct: 571 AEKQEA--TRQDHAQQLATAAEEREASL---RERDAALKQLEALEKEKAAKLEILQQQLQ 625
Query: 72 TLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQA 131
+ Q +L L + A+Q+ H QAQV EL+
Sbjct: 626 VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH-------EAQAQVAELEL 678
Query: 132 QV--EQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLE 189
Q+ EQ + E+ RV +EK + + + LKE SL++ LE
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQEQLQA---LKE----------------SLKVTKGSLE 719
Query: 190 QENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEA 249
+E R + +E+QR + T L E + ER+ E+E R + LEA
Sbjct: 720 EEKRRA--------ADALEEQQRCISELKAETRSLVEQHKRERK--ELEEERAGRKGLEA 769
Query: 250 ELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEAD 286
L +L + QA+T +L + LAEA+ A T E +
Sbjct: 770 RLQQLGEAHQAETEVLRRE--LAEAMAAQHTAESECE 804
Score = 52.4 bits (124), Expect = 9e-07
Identities = 102/463 (22%), Positives = 173/463 (37%), Gaps = 72/463 (15%)
Query: 8 EDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLT 67
E+ S +E Q LE++L A + K L E+N+ L+G L Q+ EE + +++
Sbjct: 346 EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL----EEHLSQLQDNP 401
Query: 68 KQL--DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLT------ETI 119
Q + L V + E L A + +L +LE++ QQ+ L E
Sbjct: 402 PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEK 461
Query: 120 ERLQAQVEELQAQVEQL-RGLEQLRVLREKRERRRTIHTFPCLKELCT-----------S 167
++L + + +LQ+ + L + E+L + R T EL T
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQEL 521
Query: 168 PRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEY 227
K + + L + EQ ++ L+ V L S + Q+ Q+ + + A Q++
Sbjct: 522 AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581
Query: 228 SELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADD 287
++ E LR E +A L +L+ +++ K L E L L A EA D
Sbjct: 582 AQQLATAAEEREASLR--ERDAALKQLEALEKEKAAKL-------EILQQQLQVANEARD 632
Query: 288 PQPGRGDDLGAQDGVSSPAASPGHVVRK-----SCSDTALNAIVAKDPASRHAGNLTLHA 342
AQ V+ + RK +C +TA + A L L
Sbjct: 633 ---------SAQTSVTQAQREKAELSRKVEELQACVETARQ---EQHEAQAQVAELELQL 680
Query: 343 NSVRKRGMSILR------EVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDS 396
S +++ R ++ EQ AL E + + A + R IS
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS--- 737
Query: 397 SWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKAL 439
E+KA +SL + + K LE+ + K L
Sbjct: 738 -------------ELKAETRSLVEQHKRERKELEEERAGRKGL 767
Score = 40.4 bits (93), Expect = 0.003
Identities = 92/477 (19%), Positives = 175/477 (36%), Gaps = 71/477 (14%)
Query: 49 LQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAA 108
L+++ NE + KQ L+ Q + QL DL +
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337
Query: 109 QQKIHGLTETIERLQAQVEELQAQVEQ--LRGLEQLRVLREKRE--RRRTIHTFPCLKEL 164
Q ++ LTE + + E QAQ+E+ L+ + L EK E + + L +L
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL 397
Query: 165 CTSP----------------RCKDAFRLHSSSLELGPR--------------------PL 188
+P ++A L +++ +L R
Sbjct: 398 QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457
Query: 189 EQENERLQTLVGALRSQVSQERQRKERAEREYTA--------VLQEYSEL-------ERQ 233
E+E ++L +L+ L+S +S Q KE E+ A V SEL ++Q
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517
Query: 234 LCEMEACRLRVQELEAELLE-LQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGR 292
E+ + + +E +A+L + LQQ +QA L + L+ +L Q E + Q
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 293 GDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLH-ANSVRKRGMS 351
D AQ ++ + + + L A+ + A L AN R +
Sbjct: 578 RQD-HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
Query: 352 ILREVDEQYHALLEKYEEL-----LSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEE 406
+ + + L K EEL ++ QH A + A ++ + + R +E
Sbjct: 637 SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
Query: 407 GQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHS 463
+ L + ++A+ + L+ ++ + + +++ + I+ K +T S
Sbjct: 697 --------KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745
Score = 37.7 bits (86), Expect = 0.022
Identities = 109/500 (21%), Positives = 190/500 (38%), Gaps = 67/500 (13%)
Query: 3 RAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLE-RNKELEGS-LQQMYSTNEEQV 60
+ AG+E S E QQ+ +LH A L + L + + KE+ L ST +E++
Sbjct: 855 KVAGIESHS---ELQISRQQNELAELH--ANLARALQQVQEKEVRAQKLADDLSTLQEKM 909
Query: 61 QEIEYLTKQLDTL-RHVNEQHAKVYEQL--------DLTARDLELTNHRLVLESKAAQQK 111
+L+TL R EQ +L D LE R ++AA Q
Sbjct: 910 AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA 969
Query: 112 IHGLTET----IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTS 167
+ E +ERL+A + E Q Q ++ RG ++ V R +ER R K
Sbjct: 970 MEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
Query: 168 PRCKDAFRLHSSSLELG------------PRPLEQENERLQTLVGA-------LRSQVSQ 208
+ L+ +E +QE +L+ L A LR V Q
Sbjct: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 209 ERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPD 268
+++ + E+E+ + SE + E +++ L AE+ +L+Q Q +
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGR---TEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Query: 269 DHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGH---------VVRKSCSD 319
+ EA A + A + G+ ++ + G S A + V S ++
Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Query: 320 TALNAIVAKDPASRHAGN----------LTLHANSVRKRGMSILREVDEQYHALLEKYEE 369
A VA+ N L+ + K G S +E+ A EK ++
Sbjct: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES--KELKRLVMAESEKSQK 1264
Query: 370 LLSKCRQHGAGVRHAGVQTSRPISRDSSWR-DLRGGEEGQGEVKAGEKSLSQHVEAVDKR 428
L + R A ++R R S+ R +++ E + + ++L Q + + +R
Sbjct: 1265 LEERLRLLQA---ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 429 LEQSQPEYKALFKEIFSRIQ 448
E+ E KA ++ F + Q
Sbjct: 1322 AEELGQELKAWQEKFFQKEQ 1341
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 62.8 bits (151), Expect = 6e-10
Identities = 104/415 (25%), Positives = 177/415 (42%), Gaps = 51/415 (12%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQM---YSTNEEQVQEIEYLTKQ 69
E E+ Q E+DL LAAELGK LLERN+EL L+ + + EE++Q+ + ++
Sbjct: 46 EPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRR 105
Query: 70 LDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE---RLQAQV 126
R + V + D+ A +L R + + +++ L+E E RL Q+
Sbjct: 106 GLAARGAEWEARAVELEGDVEALRAQLGEQRSE-QQDSGRERARALSELSEQNLRLSQQL 164
Query: 127 -------EELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSS 179
+ELQ +++ LRG Q + L E R + + ++ S R
Sbjct: 165 AQASQTEQELQRELDALRGQCQAQAL-AGAELRTRLESLQGENQMLQSRR---------Q 214
Query: 180 SLELGPRPLEQENE----RLQTL---VGALRSQVSQERQRKERAEREYTAVLQEYSELER 232
LE R L +E E RLQT + LR + + ERA E L L+R
Sbjct: 215 DLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 274
Query: 233 QLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEAL-LAPLTQAP---EADDP 288
++ E+E R+Q+ + LQ + A + G A+A P T++P +A P
Sbjct: 275 RVSELEE-ESRLQDADVSAASLQS-ELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSP 332
Query: 289 QPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNL-TLHANSVRK 347
QP +++ + + SP ++ + + A +D S L +L R+
Sbjct: 333 QPSPPEEI-LEPPKKRTSLSPAEILEEKEVEVA----KLQDEISLQQAELQSLREELQRQ 387
Query: 348 RGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSR-PISRDSSWRDL 401
+ + + E H+ L +E ++K + +Q +R + RDS R+L
Sbjct: 388 KELRAQEDPGEALHSALSDRDEAVNKALE-------LSLQLNRVSLERDSLSREL 435
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 60.1 bits (144), Expect = 4e-09
Identities = 103/464 (22%), Positives = 200/464 (43%), Gaps = 53/464 (11%)
Query: 1 MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV 60
+ AG + +++ E + E+DL LAA LGK LLERN+++ +QM+ +E
Sbjct: 83 LAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMH---KELT 139
Query: 61 QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE 120
++E+L ++ LR E +E R EL + L+ + +Q+IH L E
Sbjct: 140 DKLEHLEQEKHELRRRFENREGEWE-----GRVSELESDVKQLQDELERQQIH-LREADR 193
Query: 121 RLQAQVEELQAQVEQLRGLEQL-RVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSS 179
V+EL Q ++L L+QL R +R+ +H S + RL S
Sbjct: 194 EKSRAVQELSEQNQRL--LDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESL 251
Query: 180 SLEL-----GPRPLE-------QENERLQTLVGALRSQV-SQERQRKERAEREYTAVLQE 226
E+ R LE +EN+ LQ V L+ +V ERQ ++
Sbjct: 252 QAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKD---------- 301
Query: 227 YSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEAD 286
+L + E++ RL ++L+ ++ EL + + L + +LL+ + Q+ EA+
Sbjct: 302 -LQLHQSQLELQEVRLSCRQLQVKVEELTEERS-----LQSSAATSTSLLSEIEQSMEAE 355
Query: 287 DPQPGRGD-DLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSV 345
+ + R L + H+ +D+A++ + D +S + + A S+
Sbjct: 356 ELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSL 415
Query: 346 RKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGE 405
R + L E+ ++++ E ++ V ++ R R +S D E
Sbjct: 416 R----TALNELKRLIQSIVDGMEPTVTL-----LSVEMTALKEERDRLRVTS-EDKEPKE 465
Query: 406 EGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQK 449
+ Q ++ ++++++ AV+ L + + + +L ++ IQ+
Sbjct: 466 QLQKAIRDRDEAIAKK-NAVELELAKCRMDMMSLNSQLLDAIQQ 508
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 56.2 bits (134), Expect = 6e-08
Identities = 67/262 (25%), Positives = 121/262 (46%), Gaps = 22/262 (8%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIE----YLTKQLDTLRHV 76
+++ + ++HL +LG++L + + L +V++++ +L K+L+++
Sbjct: 120 KEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQ 179
Query: 77 NEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQL 136
+ + + L L R E RL + + +++ L E ERL Q E L+ Q E+L
Sbjct: 180 LQAEVENNQMLSLLNRRQE---ERLREQEERLREQEERLREQEERLCEQEERLREQEERL 236
Query: 137 RGLEQLRVLREKRERRRTIHTFPCLKE--LCTSPRCKDAFRLHSSSLELGPRPLEQENER 194
R EQ L E+ ER R C +E LC ++ R L L ++ ER
Sbjct: 237 R--EQEERLCEQEERLREHEERLCEQEERLCEQ---EERLREQEERLHEQEERLCEQEER 291
Query: 195 LQTLVGALRSQVSQERQRKER-AEREYTAVLQEYSELERQLCEMEAC--RLRVQELEAEL 251
L+ L Q + R+++ER E+E + E E +LCE E + R+ E +L
Sbjct: 292 LREQEERLCEQEERLREQEERLCEQE-----ERLREQEERLCEQEKLPGQERLLEEVEKL 346
Query: 252 LELQQMKQAKTYLLGPDDHLAE 273
LE ++ ++ + LL + L E
Sbjct: 347 LEQERRQEEQERLLERERLLEE 368
Score = 47.4 bits (111), Expect = 3e-05
Identities = 65/263 (24%), Positives = 110/263 (41%), Gaps = 22/263 (8%)
Query: 5 AGMEDFSAEEEESWYDQQDLE---QDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQ 61
AG ++E+ + +++LE + L E + L N+ E L++ EQ +
Sbjct: 154 AGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEE 213
Query: 62 EI----EYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTE 117
+ E L +Q + LR E+ + E+L L RL + + ++ L E
Sbjct: 214 RLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLRE 273
Query: 118 TIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLH 177
ERL Q E L Q E+LR E+ +E+R R + C+ RL
Sbjct: 274 QEERLHEQEERLCEQEERLREQEERLCEQEERLREQ------------EERLCEQEERLR 321
Query: 178 SSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSE-LERQLCE 236
L + ERL V L Q ++ +++ ERE +L+E E LE++
Sbjct: 322 EQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERE--RLLEEVEELLEQERLR 379
Query: 237 MEACRLRVQELEAELLELQQMKQ 259
+ RL QE EL L+++++
Sbjct: 380 QQDERLWQQETLQELERLRELER 402
Score = 40.0 bits (92), Expect = 0.004
Identities = 62/238 (26%), Positives = 99/238 (41%), Gaps = 39/238 (16%)
Query: 3 RAAGMEDFSAEEEESWYDQQD--LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV 60
R E+ E+EE +Q++ EQ+ L E + L E+ + L +++ E
Sbjct: 200 RLREQEERLREQEERLREQEERLCEQEERLR-EQEERLREQEERLCEQEERLREHEERLC 258
Query: 61 QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE 120
++ E L +Q + LR EQ +++EQ RL + + +++ L E E
Sbjct: 259 EQEERLCEQEERLR---EQEERLHEQ-----------EERLCEQEERLREQEERLCEQEE 304
Query: 121 RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS 180
RL+ Q E L Q E+LR E+ +EK + + L+E+
Sbjct: 305 RLREQEERLCEQEERLREQEERLCEQEKLPGQERL-----LEEV-------------EKL 346
Query: 181 LELGPRPLEQ----ENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 234
LE R EQ E ERL V L Q +Q + ++E L+ ELER L
Sbjct: 347 LEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERML 404
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 56.2 bits (134), Expect = 6e-08
Identities = 66/261 (25%), Positives = 117/261 (44%), Gaps = 63/261 (24%)
Query: 5 AGMEDFSAEEEESWYDQQDLEQDL-------HLAAELGKTLLERNKELEGSLQQMYSTNE 57
A +E+ A E++ ++ EQ+L L +L+ + K++E L Q+ S E
Sbjct: 1685 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744
Query: 58 EQVQE------------------IEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH 99
E VQE E L K+ DT H+ ++ + ++ T +DL+ H
Sbjct: 1745 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE----RMKKNMEQTIKDLQ---H 1797
Query: 100 RLVLESKAAQQKIHGLTETIERLQAQVEELQAQV--EQLRGLEQLRVLREKRERRRTIHT 157
RL +A Q + G + +++L+A+V EL+ ++ EQ R E ++ +R K ERR
Sbjct: 1798 RL---DEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMR-KSERR----- 1848
Query: 158 FPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAE 217
+KEL ++ L RLQ LV L+ +V +++ E AE
Sbjct: 1849 ---IKEL--------TYQTEEDKKNL---------LRLQDLVDKLQLKVKAYKRQAEEAE 1888
Query: 218 REYTAVLQEYSELERQLCEME 238
+ L ++ +++ +L E E
Sbjct: 1889 EQANTNLSKFRKVQHELDEAE 1909
Score = 44.3 bits (103), Expect = 2e-04
Identities = 70/276 (25%), Positives = 122/276 (44%), Gaps = 39/276 (14%)
Query: 13 EEEESWYDQQDLEQD-LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLD 71
+E+ Q EQD L+ A E L++ +LE +++M NE E E +
Sbjct: 884 QEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM---NERLEDEEEMNAELTA 940
Query: 72 TLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQA 131
R + ++ +++ + +D DLELT ++ E A + K+ LTE + L + +L
Sbjct: 941 KKRKLEDECSELKKDID----DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996
Query: 132 QVEQL-----RGLEQLRVLREKRE--RRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELG 184
+ + L + L+ L+V +K + + + +L S + R+ LE
Sbjct: 997 EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM---DLERA 1053
Query: 185 PRPLE------------QENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELER 232
R LE EN++LQ L L+ + Q+ + E E LQ L++
Sbjct: 1054 KRKLEGDLKLTQESIMDLENDKLQ-LEEKLKKKEFDINQQNSKIEDEQVLALQ----LQK 1108
Query: 233 QLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPD 268
+L E +A R++ELE E LE ++ +AK L D
Sbjct: 1109 KLKENQA---RIEELEEE-LEAERTARAKVEKLRSD 1140
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/281 (23%), Positives = 117/281 (41%), Gaps = 31/281 (11%)
Query: 11 SAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELE----------GSLQQMYSTNEEQV 60
S E EE + LE + + AE+ + L E+++E+E SLQ
Sbjct: 1552 SLEHEEGKILRAQLEFN-QIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR 1610
Query: 61 QEIEYLTKQLD--------TLRHVNEQHAKVYEQ---LDLTARDLELTNHRLVLESKAAQ 109
E+ + K+++ L H N A+ +Q L +D ++ V + +
Sbjct: 1611 NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1670
Query: 110 QKIHGLTETIERLQAQVEELQAQVEQLRGLEQL--RVLREKRERRRTIHTFPCLKELCTS 167
+ I + LQA++EEL+A VEQ +L + L E ER + +H+
Sbjct: 1671 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1730
Query: 168 PRCKDAFRLHSSSLELGP--RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQ 225
D +L S E R E++ ++ T + ++ +E+ ER + Q
Sbjct: 1731 KMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1790
Query: 226 EYSELERQLCEMEACRLR-----VQELEAELLELQQMKQAK 261
+L+ +L E E L+ +Q+LEA + EL+ +A+
Sbjct: 1791 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAE 1831
Score = 42.7 bits (99), Expect = 7e-04
Identities = 70/273 (25%), Positives = 113/273 (41%), Gaps = 68/273 (24%)
Query: 22 QDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTK-------QLDTLR 74
++L +++ E+ L + K L+ + QQ + + ++ L+K Q+D L
Sbjct: 978 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037
Query: 75 HVNEQHAKVYEQLDLTARDLE------------LTNHRLVLESKAAQQK--IHGLTETIE 120
EQ KV L+ R LE L N +L LE K +++ I+ IE
Sbjct: 1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 121 -------RLQAQVEELQAQVEQLRG-LEQLRVLREKRERRRTIHTFPCLKELCTSPRCKD 172
+LQ +++E QA++E+L LE R R K E+ R
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR------------------- 1138
Query: 173 AFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELER 232
S L R LE+ +ERL+ GA Q+ ++R E E+ + ++ E
Sbjct: 1139 ------SDLS---RELEEISERLEEAGGATSVQIEMNKKR----EAEFQKMRRDLEEATL 1185
Query: 233 QLCEMEACRLR------VQELEAELLELQQMKQ 259
Q E A LR V EL ++ LQ++KQ
Sbjct: 1186 Q-HEATAAALRKKHADSVAELGEQIDNLQRVKQ 1217
Score = 40.8 bits (94), Expect = 0.003
Identities = 66/283 (23%), Positives = 109/283 (38%), Gaps = 44/283 (15%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLA---AELGKTLLERNKELEGSLQQMYSTNEEQVQE- 62
MED + EE + L L A +L + E E + LQ++ S +V +
Sbjct: 1314 MEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1373
Query: 63 -IEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIER 121
+Y T + + E K+ ++L +E N K L +T R
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN-----------AKCSSLEKTKHR 1422
Query: 122 LQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSL 181
LQ ++E+L VE R L +K+ I K + S L
Sbjct: 1423 LQNEIEDLMVDVE--RSNAAAAALDKKQRNFDKI-----------LAEWKQKYEESQSEL 1469
Query: 182 ELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL------- 234
E ++E L T + L++ + + E +RE + +E S+L QL
Sbjct: 1470 ESS----QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Query: 235 CEMEACRLRVQELEAELLELQQ-MKQAKTYLLGPDDHLAEALL 276
E+E R ++LE E LELQ +++A+ L + + A L
Sbjct: 1526 HELEKVR---KQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Score = 35.8 bits (81), Expect = 0.085
Identities = 52/236 (22%), Positives = 102/236 (43%), Gaps = 14/236 (5%)
Query: 31 AAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLT 90
AA L K + EL + + ++ +E +LD + EQ K L+
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKV 1250
Query: 91 ARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRE 150
+R LE + ++ + AQ+ ++ T +LQ + EL Q+E+ L ++ R K
Sbjct: 1251 SRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS-QLTRGKLS 1309
Query: 151 RRRTIHTFPCLKELCTSPRCKDAF--RLHSS--SLELGPRPLEQENE---RLQTLVGALR 203
+ + ++L + K+A L S+ +L E+E E LQ ++
Sbjct: 1310 YTQQMEDLK--RQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 204 SQVSQERQRKERAEREYTAVLQEYSELERQLCE-MEACRLRVQELEAELLELQQMK 258
S+V+Q R + E + T +E E +++L + ++ V+ + A+ L++ K
Sbjct: 1368 SEVAQWRTKYETDAIQRT---EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
Score = 32.3 bits (72), Expect = 0.94
Identities = 28/136 (20%), Positives = 63/136 (46%), Gaps = 5/136 (3%)
Query: 4 AAGMEDFSAEEEESWYD-QQDLEQDLHLAAELGKTLLE----RNKELEGSLQQMYSTNEE 58
+A +E E++ D Q L++ +A + GK L+ R +ELEG L+ N E
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 59 QVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTET 118
V+ + +++ L + E+ K +L L+L +++ A+++ +
Sbjct: 1838 SVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1897
Query: 119 IERLQAQVEELQAQVE 134
++Q +++E + + +
Sbjct: 1898 FRKVQHELDEAEERAD 1913
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 55.8 bits (133), Expect = 8e-08
Identities = 110/463 (23%), Positives = 184/463 (39%), Gaps = 46/463 (9%)
Query: 16 ESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRH 75
+S +++ LE+ L + ++ +++ + +Q++ S NE +E L L +
Sbjct: 558 DSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQ 617
Query: 76 VNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQ--- 132
E+ + E+L +L RL E + A Q + +ER Q+E+L+ +
Sbjct: 618 QAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677
Query: 133 -----VEQLRGLEQLRVLR-----EKRERRRTIHTFPC----LKELCTSPRCKDAFRLHS 178
VE L + + R EK E + L+ T R ++A S
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS 737
Query: 179 -SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEM 237
S L L Q+ L LV L + S + R+ +AE+E T +E LE E
Sbjct: 738 LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797
Query: 238 EACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDL- 296
E R Q LE L +Q ++A L H L L Q GR +L
Sbjct: 798 EVAR---QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR---QLSGREQELE 851
Query: 297 ----GAQDGVSS--PAASPGHVVRKSCSDTALNAIVAKDPA---SRHAGNLTLHANSVRK 347
AQ V + AA + K + A+ + A+ S A L L ++
Sbjct: 852 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEG 911
Query: 348 RGMSILREVDEQYHALLEKYEE-----LLSKCRQHG--AGVRHAGVQTSRPISRDSSWRD 400
+ R++ Q A E+ E LL+K G AG+R + T S D ++
Sbjct: 912 SLFEVQRQL-AQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLD---KE 967
Query: 401 LRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEI 443
L + Q E +A + SL + A ++ L++ Q E +A ++E+
Sbjct: 968 LMAQKLVQAEREA-QASLREQRAAHEEDLQRLQREKEAAWREL 1009
Score = 50.1 bits (118), Expect = 4e-06
Identities = 117/518 (22%), Positives = 195/518 (37%), Gaps = 93/518 (17%)
Query: 9 DFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYL-- 66
D + + + ++L L L + L E + L++ E Q QE L
Sbjct: 1144 DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
Query: 67 -----TKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH------RLVLESKAAQQKIHGL 115
K+ + LR NE+ ++ + L+L N L+ E++ A K G
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 116 TET----IER----LQAQVEELQAQVEQL--------RGLEQLR---VLREKRERRRTIH 156
T +ER + +++EL+ Q++ L R L +L+ L E+ E+
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 157 TFPCLKELCTSPRCKDAFRLHSSSLELGPRPL-EQENE---RLQTLVGALRSQVSQERQR 212
T + L + R L++ R L EQE E R + L+G+L E+Q+
Sbjct: 1324 TLGLRQRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ 1380
Query: 213 KERA---EREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQ-QMKQAKTYLLGPD 268
+ A E + A E +EL +L E R Q LEAEL ++ Q + A+ L G
Sbjct: 1381 LDHARGLELKLEAARAEAAELGLRLSAAEG---RAQGLEAELARVEVQRRAAEAQLGGLR 1437
Query: 269 DHLAEAL---------LAPLTQAPEADDPQPGRGDDLGAQDGV----SSPAASPGHVVRK 315
L L P+ +P D P G G+ L + + S SPG
Sbjct: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
Query: 316 SCSDTALNAIVAK--------DPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKY 367
+ D A+ A R L +++ ++ L E++ + + +
Sbjct: 1498 ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQ----LAEMEAERDSATSRA 1553
Query: 368 EELL-----SKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHV 422
+L S+ + R +GVQ + +S R R +V E+SL
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL---- 1609
Query: 423 EAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVK 460
+A + L SQ +I K KA N TK++
Sbjct: 1610 QATESELRASQ-----------EKISKMKA--NETKLE 1634
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/249 (24%), Positives = 114/249 (45%), Gaps = 35/249 (14%)
Query: 28 LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEI-EYLTKQLDTLRHVNEQHAKVYEQ 86
L L E L + +E EG+L+ ++V+ + E L + +L +++ + +
Sbjct: 1703 LQLTVERLNGALAKVEESEGALR-------DKVRGLTEALAQSSASLNSTRDKNLHLQKA 1755
Query: 87 LDLTARDLELTNHRLVLESKA---AQQKIHGLTETIERLQAQVEELQAQVEQLRG-LEQL 142
L D ++ RL +A A+++ L E ++ L+ +V +L+ Q + G L+QL
Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815
Query: 143 R-VLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHS----------SSLELGPRPLEQE 191
R VLR+++E L T + +D RL + LE R +E+
Sbjct: 1816 REVLRQRQEGEAAA--------LNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867
Query: 192 NERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL----CEMEACRLRVQEL 247
RL+ ALR + + + K R+ + + E L+R L E+ + ++Q+L
Sbjct: 1868 ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
Query: 248 EAELLELQQ 256
EA+++ L+Q
Sbjct: 1928 EAQVVVLEQ 1936
Score = 40.8 bits (94), Expect = 0.003
Identities = 97/528 (18%), Positives = 198/528 (37%), Gaps = 90/528 (17%)
Query: 2 RRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLER-------NKELEGSLQQMYS 54
R+ +E + E+E + L L A G+TL E + LEGSL ++
Sbjct: 859 RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV-- 916
Query: 55 TNEEQVQEIEYLTKQLDT---------------LRHVNEQHAKVYEQLDLTARDLELTNH 99
+ Q+ ++E +QL+ L + +Q E+ L D EL
Sbjct: 917 --QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL---DKELMAQ 971
Query: 100 RLVLESKAAQQKIH----GLTETIERLQAQVE----ELQAQVEQLRG------------- 138
+LV + AQ + E ++RLQ + E EL+A+ QL+
Sbjct: 972 KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARL 1031
Query: 139 -------LEQLRVLREKR---------ERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLE 182
E++ L+++R E+++ + K + L + SLE
Sbjct: 1032 EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
Query: 183 L--GPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL-CEMEA 239
+ R + E+ ++ V AL S++ R ++E A + ++ E R L + ++
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151
Query: 240 CRLRVQELEAELLELQQMKQA-KTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGA 298
C +EL +L L+ + + LL L E+ Q EA + + G+
Sbjct: 1152 CLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKE 1211
Query: 299 QDGVSSPAASPGHVVRKSCSDTALNAIV-------------AKDPASRHAGNLTLHANSV 345
++ + V+K+ S+ + A+ + AG L V
Sbjct: 1212 REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271
Query: 346 RKRGMSILREVDE--QYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRG 403
+ + RE+ E + +L+ L + G G + + S R+ G
Sbjct: 1272 ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK-----ESRRETLG 1326
Query: 404 GEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTK 451
+ + +A + + Q ++ ++L++ + E++ + + +++ +
Sbjct: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
Score = 36.2 bits (82), Expect = 0.065
Identities = 48/180 (26%), Positives = 75/180 (41%), Gaps = 27/180 (15%)
Query: 116 TETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFR 175
TE L Q EE Q ++L +E L L + R R + +K S R + A R
Sbjct: 71 TEMASLLSLQ-EENQLLQQELSRVEDL--LAQSRAERDEL----AIKYNAVSERLEQALR 123
Query: 176 LHSSSLELGP------------RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAV 223
L LE R L++E + + A + ++ Q +R + +
Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183
Query: 224 LQEYSELERQLC----EMEACRLR----VQELEAELLELQQMKQAKTYLLGPDDHLAEAL 275
+ SELE+QL E+E RLR Q+LE+ L+ L++ +Q L + L E L
Sbjct: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 55.1 bits (131), Expect = 1e-07
Identities = 86/429 (20%), Positives = 175/429 (40%), Gaps = 64/429 (14%)
Query: 20 DQQDLEQDLHLAAEL-GKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNE 78
+Q+DL + LH E+ K ER K+L+ L +M EE +E
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE---------------- 1474
Query: 79 QHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQV----- 133
++ +Q+ + ++ + E+K+ Q+++ TIERL + ++++QV
Sbjct: 1475 --SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532
Query: 134 EQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENE 193
E+ L +L +L+E+R++ T L+ S C+ SL+L L ++ E
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE--------SLKLALEGLTEDKE 1584
Query: 194 RLQTLVGALRS----QVSQERQRKERAEREYTAVLQEY----SELERQLCEMEACRLRVQ 245
+L + +L+S + ++ +++ + ++EY +LQ Y +E ER +EA R Q
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644
Query: 246 ELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSP 305
EL +L + K+ L + E + + + ++ + + +L ++
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRA 1701
Query: 306 AASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLE 365
P K C +T L+ +N+ K L V +Y L +
Sbjct: 1702 EVHPAGDTAKECMETLLS------------------SNASMKEE---LERVKMEYETLSK 1740
Query: 366 KYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAV 425
K++ L+S+ V+ Q +S+ ++ + + G +S+ E
Sbjct: 1741 KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
Query: 426 DKRLEQSQP 434
D ++P
Sbjct: 1801 DSLSMSTRP 1809
Score = 44.7 bits (104), Expect = 2e-04
Identities = 59/270 (21%), Positives = 112/270 (41%), Gaps = 40/270 (14%)
Query: 12 AEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLD 71
A+ + S + + LE DL + EL L E E + + S EE +Q
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV--------- 2397
Query: 72 TLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQA 131
+ + +QH K ++L+ E N L E+K A K + L ET++ ++ + + +A
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKA 2457
Query: 132 QVEQ-LRGLEQLRVLREKRERRRTIHTFPCLKE----------------LCTSPRCKDAF 174
Q++ ++ + L + +R R + + L+E + + K+
Sbjct: 2458 QLDSFVKSMSSL-----QNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512
Query: 175 RLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAV-LQEYSELERQ 233
R S ++ L EN +L + R ++Q K+ +++ V LQ+ ELE +
Sbjct: 2513 RGLRSHMD----DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENK 2568
Query: 234 LCEMEACRLRVQELEAELLE----LQQMKQ 259
++E +E +L LQ+ KQ
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
Score = 39.3 bits (90), Expect = 0.008
Identities = 58/299 (19%), Positives = 124/299 (41%), Gaps = 34/299 (11%)
Query: 7 MEDFSAE----EEESWYDQQDLEQDLHLAAELGKTLLE----RNKELEGSLQQMYSTNEE 58
M+D ++E + E ++DL Q + + K LLE +NKELE ++ +E
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 59 QVQEIEYLTKQLDTLRHVNEQHAKVYEQL---------DLTARDLELTNHRLVLESKAAQ 109
+ E L + + L+ + +K E L +TA E T + K +
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
Query: 110 QKIHGLTETIERLQAQVEELQAQV--EQLRGLEQLRVLREK-RERRRTIHTFPCLKELCT 166
+++H L+ Q ++ EL+ ++ Q +++ + +K ++ + +H + T
Sbjct: 2639 EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNET 2698
Query: 167 SPRCKDAFRLHSSSLELGPRPL--EQENERLQTLVGALRSQVSQERQRKERAEREYTAVL 224
+ L +E+ + L +EN+ L + + +S + ++ A E +
Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
Query: 225 QEYSELERQLCEMEACRLRVQELEAELLE------------LQQMKQAKTYLLGPDDHL 271
++Y ++L +++ L +E +A L E L +++ LL D+ L
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
Score = 37.7 bits (86), Expect = 0.022
Identities = 51/261 (19%), Positives = 112/261 (42%), Gaps = 30/261 (11%)
Query: 8 EDFSAEEE--ESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEY 65
E +AEE E D ++EQ L + + K L + + S+ + ++ + +E++
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 66 LTKQLDT----LRHVNEQHAKVYEQ---LDLTARDLELTNHRLVLESKAAQQKIHGLTET 118
L ++ D L + EQ E+ L TA + T + + Q++ E
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 119 IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHS 178
+ L +Q+E+ QV+ + + L+ +R+ H + L++ S K
Sbjct: 2817 LLHLSSQLEDSYNQVQSFS--KAMASLQNERD-----HLWNELEKFRKSEEGKQR----- 2864
Query: 179 SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEME 238
S+ + P E V +L+ +S + ++R +E + Q+Y ++ +++ E+
Sbjct: 2865 SAAQPSTSPAE---------VQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
Query: 239 ACRLRVQELEAELLELQQMKQ 259
+ ++QE + + Q M++
Sbjct: 2916 PLKAQLQEYQDKTKAFQIMQE 2936
Score = 36.6 bits (83), Expect = 0.050
Identities = 63/298 (21%), Positives = 114/298 (38%), Gaps = 59/298 (19%)
Query: 11 SAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQ---EIEYLT 67
++ EE S + L Q L E LL + +LE S Q+ S ++ E ++L
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDE---QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 68 KQLDTLRHVNEQHAKVYEQ----------LDLTARDLELTNHRLVLESKAAQQK------ 111
+L+ R E + Q L L+ RL+ E K QQ+
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 112 ----IHGLTETIERLQAQVEELQAQVEQLRG--------LEQLRV------LREKRERRR 153
+H L ++ Q + + Q E+LR L QLR+ + E+R + +
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969
Query: 154 TI-----------HTFPCLKELCTSPRCKDAFRLH--------SSSLELGPRPLEQENER 194
+ H ++EL +S ++ +S+ G + L E E
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETEL 3029
Query: 195 LQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELL 252
L+T + ++ Q+ R ++ ++ +L+E + L QLC+ Q+ +LL
Sbjct: 3030 LRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL 3087
Score = 35.8 bits (81), Expect = 0.085
Identities = 57/271 (21%), Positives = 109/271 (40%), Gaps = 35/271 (12%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEE------QVQEIEYLT------K 68
+++L++ + L + + E K + + + +EE QV+E+ +T K
Sbjct: 708 EKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVK 767
Query: 69 QLD-TLRHVNEQHAKVYEQLDLTARDLELTN--HRLVLESKAAQQKIHGLTETIERLQAQ 125
QL+ L Q YE TA D LT H L +E+K+ KI L ++ +Q Q
Sbjct: 768 QLEMNLAEAERQRRLDYESQ--TAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQ 825
Query: 126 VEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGP 185
E + L+ Q + R H ++EL + K
Sbjct: 826 FSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK-------------- 871
Query: 186 RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEME-ACRLRV 244
E E ++ L+ + V +Q E +++ T + +E QL E + + + +
Sbjct: 872 ---ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 245 QELEAELLELQQMKQAKTYLLGPDDHLAEAL 275
+ L+ +L L + ++AK + D+ ++ L
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959
Score = 33.9 bits (76), Expect = 0.32
Identities = 46/258 (17%), Positives = 105/258 (40%), Gaps = 57/258 (22%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYL 66
+ + S +++ + L+ +LH +++ E N + +Q+ + E+ V E++ +
Sbjct: 13 LHELSGDDDTDQNMRAPLDPELHQESDM-----EFNNTTQEDVQERLAYAEQLVVELKDI 67
Query: 67 TKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQV 126
+Q D + L +D L R ++K + K+H + + L +
Sbjct: 68 IRQKD---------------VQLQQKDEALQEERKAADNKIKKLKLHAKAK-LTSLNKYI 111
Query: 127 EELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPR 186
EE++AQ + L T P+ ++ H S
Sbjct: 112 EEMKAQGGTV---------------------------LPTEPQSEEQLSKHDKSSTEEEM 144
Query: 187 PLEQENERLQT---LVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLR 243
+E+ +LQ L+ L++Q++Q + + + + ++E+ +++QL E E
Sbjct: 145 EIEKIKHKLQEKEELISTLQAQLTQAQAEQPA---QSSTEMEEFVMMKQQLQEKEEF--- 198
Query: 244 VQELEAELLELQQMKQAK 261
+ L+A+L + Q + A+
Sbjct: 199 ISTLQAQLSQTQAEQAAQ 216
Score = 32.0 bits (71), Expect = 1.2
Identities = 51/256 (19%), Positives = 106/256 (41%), Gaps = 34/256 (13%)
Query: 29 HLAAELGKTLLERNKE---LEGSLQQMYSTNEEQVQEIEYLTKQL-DTLRHVNEQHAKVY 84
H EL + +L KE L+ LQ+ ++ + +++ + + L + L+ + + ++
Sbjct: 1157 HWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ 1216
Query: 85 EQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRV 144
EQ D +++ E +L ++ I G + ++ Q GLE+
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ--------QESCSSTPGLEE--P 1266
Query: 145 LREKRERRRTIHTFPCLKE-LCTS--PRCKDAFRLHSSS----LELGPRPLEQENERLQT 197
L + E+ HT P L+ LC +DA L + ++ + +E E L+
Sbjct: 1267 LFKATEQH---HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL 1323
Query: 198 LVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQM 257
V + S+++++ + V Q ++ +Q E+E+ + E E LQQ
Sbjct: 1324 KVSSTTSELTKKSEE----------VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373
Query: 258 KQAKTYLLGPDDHLAE 273
++ + +HL E
Sbjct: 1374 LESSQLQIAGLEHLRE 1389
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/256 (24%), Positives = 117/256 (45%), Gaps = 19/256 (7%)
Query: 15 EESWYDQQDLEQDLHLAAELGKTLLERNKE----LEGSLQQMYSTNEEQVQEI-EYLTKQ 69
EE +QDL QDL +A E + LL + + L+G+L++ S++++++ ++ E +
Sbjct: 730 EELLQAKQDL-QDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 70 LDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEEL 129
L LR E+ K E L + E + K Q++ L E L+ +V +L
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKD-----AFRLHSSSLELG 184
Q Q+E L+G E + K ++ L+E R ++ A R + LE
Sbjct: 849 QRQIEDLKGDE----AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 185 PRPLEQENERLQTLVGALRSQVSQE---RQRKERAEREYTAVLQEYSELERQLCE-MEAC 240
L Q + + L L+ + Q+ R+ K E E + + +L++++ + +EA
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 241 RLRVQELEAELLELQQ 256
R EL+ +L E ++
Sbjct: 965 RTSTLELQNQLDEYKE 980
Score = 39.3 bits (90), Expect = 0.008
Identities = 52/263 (19%), Positives = 111/263 (42%), Gaps = 31/263 (11%)
Query: 7 MEDFSAEEEESWYDQQ-------DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQ 59
+ D+ ++E+ +Q DLE +L + L K++E + Q+ EE+
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Query: 60 VQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTET- 118
+ L++++ R EQ Q +DLE L ++K + +I L +
Sbjct: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 119 -------IERLQAQVEELQAQVE-QLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRC 170
+ +++A++ EL+ ++E + R L++ + ER+ E +
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
Query: 171 KDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSEL 230
KD L +++ E+E +RL++ K++ +RE + L
Sbjct: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLES--------------SKKKLQRELEEQMDMNEHL 1246
Query: 231 ERQLCEMEACRLRVQELEAELLE 253
+ QL M+ LR+++L +++L+
Sbjct: 1247 QGQLNSMKK-DLRLKKLPSKVLD 1268
Score = 33.9 bits (76), Expect = 0.32
Identities = 59/298 (19%), Positives = 116/298 (38%), Gaps = 41/298 (13%)
Query: 14 EEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQ---- 69
E E W+ + +E+ A++ + EL+ L + N ++ E++ K+
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 70 -----------LDTLRHVNEQHAKVYEQLD--LTARD-LELTNHRLVLESKAAQQKIHGL 115
D +R + E+ D LT R LE T L E +A
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 116 TETIERLQAQVEELQAQVEQLRGLEQL---RVLREKRERRRTIHTFPCLKELCTSPRCKD 172
+ +++++ +V +L+ ++E+ R L R+ R + + + + + C D
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLEC-D 1118
Query: 173 AFRLHSSSLELGPRPLEQE---NERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSE 229
L + +L R + E + LV + +++++ R E ER+ +
Sbjct: 1119 KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR 1178
Query: 230 LERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADD 287
LER++ E+ V +++ E L L K D L+ L A Q EA++
Sbjct: 1179 LERKVKEL------VMQVDDEHLSLTDQK----------DQLSLRLKAMKRQVEEAEE 1220
>gi|45505178 cancer antigen 1 [Homo sapiens]
Length = 641
Score = 53.1 bits (126), Expect = 5e-07
Identities = 59/255 (23%), Positives = 121/255 (47%), Gaps = 30/255 (11%)
Query: 15 EESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTN---EEQVQEIEY-LTKQL 70
E+S Q +++D+ L L K L N++ E +Q++ +N E++V+E++ +TKQ
Sbjct: 154 EQSAESLQPVQEDMALNEVLQK-LKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQ 212
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ +N+ V E ++ ++++LE ++ + L E + Q ++E +
Sbjct: 213 VFIDVINKLKENVEELIE--------DKYKIILEKNDTKKTLQNLEEVLANTQKHLQESR 264
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKE-LCTSPRCKDAFRLHSSSLELGPRPLE 189
E L QL+ + K + CL+E T + K+ ++ E
Sbjct: 265 NDKEML----QLQFKKIKAN-------YVCLQERYMTEMQQKNKSVSQYLEMDKTLSKKE 313
Query: 190 QENERLQTLVGALRSQVSQE----RQRKERAEREYTAVLQEYSELERQ-LCEMEACRLRV 244
+E ERLQ L L + ++ KE E+E+ ++ +E+ +LE++ L E + + R+
Sbjct: 314 EEVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLKSRL 373
Query: 245 QELEAELLELQQMKQ 259
++L ++ LQ M +
Sbjct: 374 EKLLTQVRNLQFMSE 388
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/280 (22%), Positives = 120/280 (42%), Gaps = 60/280 (21%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAEL-------GKTLLERNKELEGSLQQMYSTNEEQ 59
+ED + +E++ ++ E++L A E +LL + K+LE + +M EE
Sbjct: 1697 LEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEV 1756
Query: 60 VQEI------------------EYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRL 101
VQE E L K+ DT+ H+ + E ++ T DL+ RL
Sbjct: 1757 VQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLE----RTRENMEQTITDLQ---KRL 1809
Query: 102 VLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCL 161
++A Q + G + I++L+++V EL+ ++E + R +R C+
Sbjct: 1810 ---AEAEQMALMGSRKQIQKLESRVRELEGELEG-------EIRRSAEAQRGARRLERCI 1859
Query: 162 KELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYT 221
KEL ++ L R+QT + L+ +V +Q+ E AE +
Sbjct: 1860 KEL--------TYQAEEDKKNL---------SRMQTQMDKLQLKVQNYKQQVEVAETQAN 1902
Query: 222 AVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAK 261
L +Y + + +L E++ R V E + L+++ + K
Sbjct: 1903 QYLSKYKKQQHELNEVKE-RAEVAESQVNKLKIKAREFGK 1941
Score = 45.8 bits (107), Expect = 8e-05
Identities = 62/250 (24%), Positives = 98/250 (39%), Gaps = 49/250 (19%)
Query: 21 QQDLEQDLHLAAELGKTLLERN-------KELEGSLQQMYSTNEEQVQEIEYLTKQLDTL 73
QQ L+ DLH+ E +L + N ELEG+L+Q +E+ L L
Sbjct: 1016 QQTLD-DLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN 1074
Query: 74 RHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQV 133
R + E L+ + R L + LE K+ + +LQ V+ELQ Q+
Sbjct: 1075 R-------ESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQI 1127
Query: 134 EQLR-GLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQEN 192
+ L+ LE R R K ER R T + L N
Sbjct: 1128 KDLKEKLEAERTTRAKMERERADLT----------------------------QDLADLN 1159
Query: 193 ERLQTLVGALRSQV---SQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEA 249
ERL+ + G+ +Q+ ++ + ++ R+ + L + A L ELE
Sbjct: 1160 ERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSL--AELEG 1217
Query: 250 ELLELQQMKQ 259
++ LQQ+KQ
Sbjct: 1218 QVENLQQVKQ 1227
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/249 (20%), Positives = 106/249 (42%), Gaps = 30/249 (12%)
Query: 28 LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQL 87
L AEL + L E+++E+E ++ T I+ L LD+ + ++ +++
Sbjct: 1578 LEAKAELERKLSEKDEEIENFRRKQQCT-------IDSLQSSLDSEAKSRIEVTRLKKKM 1630
Query: 88 DLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEEL---------QAQVEQLRG 138
+ ++EL + A + + L I+ LQ Q+++ Q V + R
Sbjct: 1631 EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRN 1690
Query: 139 ------LEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQEN 192
LE LR L+E+ ER R + +EL + + F ++SL + LE +
Sbjct: 1691 SLLQSELEDLRSLQEQTERGRRLSE----EELLEATERINLFYTQNTSLLSQKKKLEADV 1746
Query: 193 ERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQ----ELE 248
R+Q + + ++ ++A E + +E + + + +E R ++ +L+
Sbjct: 1747 ARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQ 1806
Query: 249 AELLELQQM 257
L E +QM
Sbjct: 1807 KRLAEAEQM 1815
Score = 34.3 bits (77), Expect = 0.25
Identities = 57/252 (22%), Positives = 105/252 (41%), Gaps = 53/252 (21%)
Query: 56 NEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHR--LVLESKAAQQKIH 113
+ E +E+ L ++ L+ E+ +++ +L A+ + LT + L+L+ +A Q+ +
Sbjct: 854 SSEVGEEVAGLKEECAQLQKALEKSE--FQREELKAKQVSLTQEKNDLILQLQAEQETLA 911
Query: 114 GLTETIE-------RLQAQVEELQAQVEQ---------LRGLE---------------QL 142
+ E E +L+A+V+EL +VE+ RG + +
Sbjct: 912 NVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLET 971
Query: 143 RVLREKRERRRTIHTFPCLKELC---------TSPRCKDAFRLHSSSL------ELGPRP 187
+++ ++E+R T H L E + K H +L E
Sbjct: 972 MLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSS 1031
Query: 188 LEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCE--MEACRLRVQ 245
L + N +L+ V L + QER+ + ERE L+ +L R+ E + R +
Sbjct: 1032 LSKANLKLEQQVDELEGALEQERKARMNCERELHK-LEGNLKLNRESMENLESSQRHLAE 1090
Query: 246 ELEAELLELQQM 257
EL + LEL QM
Sbjct: 1091 ELRKKELELSQM 1102
Score = 29.6 bits (65), Expect = 6.1
Identities = 55/271 (20%), Positives = 104/271 (38%), Gaps = 31/271 (11%)
Query: 2 RRAAGMEDFSAEEEESWYDQQDLEQD---LHLAAELGKTLLERNKELEGSLQQMYSTNEE 58
R A + + + E +Q LE+D L L + T +E+ + + +++ + EE
Sbjct: 1207 RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEE 1266
Query: 59 QVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTET 118
++ E T +LD + + A DL +L ES +++
Sbjct: 1267 RLHEA---TAKLDKVTQL--------------ANDLAAQKTKLWSESGEFLRRLEEKEAL 1309
Query: 119 IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHS 178
I +L + Q+E LRG ++ +E + + H + C R + +
Sbjct: 1310 INQLSREKSNFTRQIEDLRG----QLEKETKSQSALAHALQKAQRDCDLLR--EQYEEEQ 1363
Query: 179 SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSE----LERQL 234
R L + N + + V Q + E A++E LQE +E +
Sbjct: 1364 EVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARN 1423
Query: 235 CEMEACRLRVQ-ELEAELLELQQMKQAKTYL 264
+E R ++Q EL L +L +++ A L
Sbjct: 1424 ASLERARHQLQLELGDALSDLGKVRSAAARL 1454
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/208 (25%), Positives = 102/208 (49%), Gaps = 14/208 (6%)
Query: 33 ELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLD--TLRHVNEQHAKVYEQLDLT 90
EL K L +ELE ++++ + NE + QE+E + K+L+ R E+ ++ Q++L
Sbjct: 325 ELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQ 384
Query: 91 AR-DLELTNHRLVLESKAAQ--QKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLRE 147
AR EL +L+ + Q QK L + ++R++ ++E++ ++++ LE R R+
Sbjct: 385 ARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-ELEDMYLKLQE--ALEDERQARQ 441
Query: 148 KRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVS 207
E R + L+E + + + L +QE E + L+ Q
Sbjct: 442 DEETVRKLQA-RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR----VLKEQAL 496
Query: 208 QE-RQRKERAEREYTAVLQEYSELERQL 234
QE ++ E+ E E L++Y E++++L
Sbjct: 497 QEAMEQLEQLELERKQALEQYEEVKKKL 524
Score = 38.1 bits (87), Expect = 0.017
Identities = 41/154 (26%), Positives = 69/154 (44%), Gaps = 13/154 (8%)
Query: 104 ESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKE 163
+ K Q+ I + TI L+ + Q R + + L E+ E R + E
Sbjct: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
Query: 164 LCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTA- 222
+ ++ + E R E+E +RLQT V L+++ S E +R++ ++
Sbjct: 350 ----SKQQELEAVRKKLEEAASRAAEEEKKRLQTQV-ELQARFSTELEREKLIRQQMEEQ 404
Query: 223 VLQEYSELERQLCEMEACRLRVQELEAELLELQQ 256
V Q+ SELE+ L RV+ELE L+LQ+
Sbjct: 405 VAQKSSELEQYL-------QRVRELEDMYLKLQE 431
Score = 37.7 bits (86), Expect = 0.022
Identities = 31/143 (21%), Positives = 63/143 (44%), Gaps = 12/143 (8%)
Query: 1 MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV 60
++R +ED + +E+ D++ QD +L LLE L++ + ++ +
Sbjct: 416 LQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAI 475
Query: 61 QEIEYLTKQLDTLRHVNEQH-AKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETI 119
Q E ++L+ R + EQ + EQL+ +L LE K A ++ + + +
Sbjct: 476 QTTEAEKQELENQRVLKEQALQEAMEQLE-----------QLELERKQALEQYEEVKKKL 524
Query: 120 ERLQAQVEELQAQVEQLRGLEQL 142
E + + + +V GL +L
Sbjct: 525 EMATNKTKSWKDKVAHHEGLIRL 547
Score = 34.3 bits (77), Expect = 0.25
Identities = 35/146 (23%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Query: 10 FSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQ 69
FS E E +Q +E+ + + + L+R +ELE MY +E +++ +
Sbjct: 387 FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELE----DMYLKLQEALEDERQARQD 442
Query: 70 LDTLRHVNEQHAKVYEQLDLTARDLE---LTNHRLVLESKAAQQKIHGLTETIER-LQAQ 125
+T+R + A++ E+ +LE L + + ++A +Q++ E+ LQ
Sbjct: 443 EETVRKL---QARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEA 499
Query: 126 VEEL-QAQVEQLRGLEQLRVLREKRE 150
+E+L Q ++E+ + LEQ +++K E
Sbjct: 500 MEQLEQLELERKQALEQYEEVKKKLE 525
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 52.4 bits (124), Expect = 9e-07
Identities = 71/292 (24%), Positives = 126/292 (43%), Gaps = 42/292 (14%)
Query: 10 FSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQ 69
F +E +Q +E++L+ + K+LE L+ M + +EQ +I LT+Q
Sbjct: 1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
Query: 70 L-----------DTLR--------HVNEQHAKVYEQLDLTARDLELTNHRLVLES----- 105
L D LR H+ E+ + E+L + ++E +L+ E
Sbjct: 1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQ-RTQEELRRLSSEVEALRRQLLQEQESVKQ 1677
Query: 106 ---------KAAQQKIHGLTET---IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRR 153
KA + K L E+ IERLQ+ E L E L E+LR LR + + R
Sbjct: 1678 AHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK--EHLMLEEELRNLRLEYDDLR 1735
Query: 154 TIHTFPCLKELCTSPRCKDAFRLHSS-SLELGP--RPLEQENERLQTLVGALRSQVSQER 210
+ + T + ++ ++ +LEL L++E E L+ + + Q +
Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEAS 1795
Query: 211 QRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKT 262
R + ++ + T V+QE L ++ +E + R+Q LE EL + +A+T
Sbjct: 1796 NRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1847
Score = 47.0 bits (110), Expect = 4e-05
Identities = 62/256 (24%), Positives = 112/256 (43%), Gaps = 22/256 (8%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTN-EEQVQEIEYLTKQLDTLRHVNEQHAK 82
+E+D+ G + +R ++LE L+Q+ EE V+ + L T++ N++ +
Sbjct: 1426 VEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIER 1485
Query: 83 VYEQLDLTARD---LELTNHRLVLESKAAQQKIHGLTETIERLQAQVEEL------QAQV 133
+ + +D D LE N RL Q+ TETI +L+ Q +EL +V
Sbjct: 1486 LKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERV 1545
Query: 134 EQLRGLEQLRVLREKR-------ERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPR 186
Q R ++ + R + ++++ LK + CK + LE R
Sbjct: 1546 SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR--KKLEEELEGMRR 1603
Query: 187 PLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEY-SELERQLCEMEACRLRVQ 245
L+++ ++ L L Q S ++R E R+ VL + E +R E+ V+
Sbjct: 1604 SLKEQAIKITNLTQQL-EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Query: 246 ELEAELLELQQ-MKQA 260
L +LL+ Q+ +KQA
Sbjct: 1663 ALRRQLLQEQESVKQA 1678
Score = 30.8 bits (68), Expect = 2.7
Identities = 49/243 (20%), Positives = 87/243 (35%), Gaps = 51/243 (20%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKV 83
LE++L LA + +NK L+ +LQ+ + E +L +L + Q
Sbjct: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQA-------ECSQFKAKLASLEELKRQ---- 1085
Query: 84 YEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLR 143
L+ K+A+Q + I+ L ++ L ++E
Sbjct: 1086 -----------------AELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED-------- 1120
Query: 144 VLREKRERRRTIHTFPCLK----ELCTSPRC-KDAFRLHSSSLELGPRPLEQENERLQTL 198
EKR R+ F K +L + +C K+ E + E E ERL+ L
Sbjct: 1121 ---EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL 1177
Query: 199 VGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMK 258
+ +E RK E E V Y+E L + + + + + +Q+
Sbjct: 1178 -------LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKED 1230
Query: 259 QAK 261
+K
Sbjct: 1231 DSK 1233
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 52.4 bits (124), Expect = 9e-07
Identities = 70/281 (24%), Positives = 127/281 (45%), Gaps = 72/281 (25%)
Query: 5 AGMEDFSAEEEESWYDQQDLEQDLHLAAEL-------GKTLLERNKELEGSLQQMYSTNE 57
A +E+ A E + ++ EQ+L A+E +L+ K+LE + Q+ E
Sbjct: 1687 AEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 58 EQVQEI------------------EYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH 99
+ VQE E L K+ DT H+ ++ + ++ T +DL+L
Sbjct: 1747 DIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE----RMKKNMEQTVKDLQL--- 1799
Query: 100 RLVLESKAAQQKIHGLTETIERLQAQVEELQAQV--EQLRGLEQLRVLREKRERRRTIHT 157
RL +A Q + G + I++L+A+V EL+++V EQ +E ++ LR K ERR
Sbjct: 1800 RL---DEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLR-KHERR----- 1850
Query: 158 FPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENE---RLQTLVGALRSQVSQERQRKE 214
+KEL E++ + RLQ LV L+++V +++ E
Sbjct: 1851 ---VKELTYQ--------------------TEEDRKNILRLQDLVDKLQTKVKAYKRQAE 1887
Query: 215 RAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQ 255
AE + L ++ +L+ E+E + R E+++ +L+
Sbjct: 1888 EAEEQSNVNLAKFRKLQH---ELEEAKERADIAESQVNKLR 1925
Score = 45.8 bits (107), Expect = 8e-05
Identities = 67/259 (25%), Positives = 107/259 (41%), Gaps = 56/259 (21%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERN-KELEGSLQQMYSTNEEQVQEIEYLTKQLD 71
E + D +E+D KT LE+ +LEGSL+Q + L L+
Sbjct: 1005 EAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE-----------KKLCMDLE 1053
Query: 72 TLRHVNEQHAKVYEQLDL-TARDLELTNHRLV---LESKAAQQKIHGLTETIERLQAQVE 127
+ E K+ ++ + T D + N +L E Q KI +LQ +++
Sbjct: 1054 RAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK 1113
Query: 128 ELQAQVEQLRG-LEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPR 186
ELQA++E+L +E R R K E++R S L R
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQR-------------------------SDLS---R 1145
Query: 187 PLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLR--- 243
LE+ +ERL+ GA +Q+ ++R E E+ + ++ E Q E A LR
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKR----EAEFQKMRRDLEESTLQ-HEATAAALRKKH 1200
Query: 244 ---VQELEAELLELQQMKQ 259
V EL ++ LQ++KQ
Sbjct: 1201 ADSVAELGEQIDSLQRVKQ 1219
Score = 40.0 bits (92), Expect = 0.004
Identities = 54/255 (21%), Positives = 104/255 (40%), Gaps = 41/255 (16%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNE-EQVQEIEYLTKQLDTLRHVNEQ 79
++ E++ AEL + + + N E+ + Y T+ ++ +E+E K+L E+
Sbjct: 1348 REQYEEEQEAKAELQRGMSKANSEV-AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
Query: 80 HA-----------KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEE 128
H K ++L DL + R A +K + + + + EE
Sbjct: 1407 HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEE 1466
Query: 129 LQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPL 188
QA++E +K R + F + K+A+ LE L
Sbjct: 1467 TQAELEA----------SQKESRSLSTELF----------KVKNAYEESLDHLET----L 1502
Query: 189 EQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELE 248
++EN+ LQ + L Q+++ + E+ + E SEL+ L E EA ++ E
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEA---SLEHEE 1559
Query: 249 AELLELQ-QMKQAKT 262
++L +Q ++ Q K+
Sbjct: 1560 GKILRIQLELNQVKS 1574
Score = 38.1 bits (87), Expect = 0.017
Identities = 55/244 (22%), Positives = 107/244 (43%), Gaps = 26/244 (10%)
Query: 31 AAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLT 90
A E L++ +LE ++++ E++ + LT + L + K + L+LT
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 91 ARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRE 150
+E H + K +++ GL ETI +L + + LQ +Q L+ L++ +K
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT--LDDLQMEEDKVN 1022
Query: 151 RRRTIHT------------FPCLKELCTSPRCKDAFRLHSSSLELGPR-PLEQENERLQT 197
T K+LC + A R L+L ++ EN++ Q
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMD--LERAKRKLEGDLKLAQESTMDTENDK-QQ 1079
Query: 198 LVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQM 257
L L+ + + + + E E +Q L++++ E++A R++ELE E +E ++
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAIQ----LQKKIKELQA---RIEELEEE-IEAERA 1131
Query: 258 KQAK 261
+AK
Sbjct: 1132 SRAK 1135
Score = 36.6 bits (83), Expect = 0.050
Identities = 56/231 (24%), Positives = 98/231 (42%), Gaps = 33/231 (14%)
Query: 39 LERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTN 98
L K++EG L NE ++Q L H N Q A+ L T L+ T
Sbjct: 1616 LRIKKKMEGDL------NEMEIQ-----------LNHANRQAAEALRNLRNTQGILKDTQ 1658
Query: 99 HRLVLESKAAQQKIHGLTETIER----LQAQVEELQAQVEQL-RGLEQL-RVLREKRERR 152
L ++ Q + +ER +QA+VEEL+A +E+ RG + + L + ER
Sbjct: 1659 LHLD-DAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERV 1717
Query: 153 RTIHTFPCLKELCTSPRCKDAFRLHSSSLE---LGPRPLEQENERLQTLVGALRSQVSQE 209
+ +HT + T + + +E R E++ ++ T + ++ +E
Sbjct: 1718 QLLHT-QNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKE 1776
Query: 210 RQRKERAEREYTAVLQEYSELERQLCEMEACRLR-----VQELEAELLELQ 255
+ ER + Q +L+ +L E E L+ +Q+LEA + EL+
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Score = 32.7 bits (73), Expect = 0.72
Identities = 44/204 (21%), Positives = 90/204 (44%), Gaps = 18/204 (8%)
Query: 62 EIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIER 121
+I+ L K +T ++ A + E+ + T +L T + K ++K+ L +
Sbjct: 839 KIKPLLKSAET----EKEMANMKEEFEKTKEELAKTEAK----RKELEEKMVTLMQEKND 890
Query: 122 LQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSL 181
LQ QV QA+ + L E+ R + + I +KE+ + R +D +++ L
Sbjct: 891 LQLQV---QAEADALADAEE----RCDQLIKTKIQLEAKIKEV--TERAEDEEEINAE-L 940
Query: 182 ELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACR 241
R LE E L+ + L +++ + K E + + +E + L+ + ++ +
Sbjct: 941 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 242 LRVQELEAELLELQQMKQAKTYLL 265
+QE + L+ QM++ K L
Sbjct: 1001 KALQEAHQQTLDDLQMEEDKVNTL 1024
Score = 29.3 bits (64), Expect = 7.9
Identities = 42/225 (18%), Positives = 90/225 (40%), Gaps = 44/225 (19%)
Query: 39 LERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNE---QHAKVYEQLDLTARDLE 95
+E + + + ++M T E+Q+ EI+ TK+ + R +NE Q A+++ + +R L+
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIK--TKEEEQQRLINELSAQKARLHTESGEFSRQLD 1296
Query: 96 LTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTI 155
+ + S+ Q Q+EEL+ Q+E+ E + +
Sbjct: 1297 EKDAMVSQLSRGKQA-----------FTQQIEELKRQLEE-----------ETKAKSTLA 1334
Query: 156 HTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKER 215
H + C +L E+E E L + S+ Q + +
Sbjct: 1335 HALQSARHDC----------------DLLREQYEEEQEAKAELQRGMSKANSEVAQWRTK 1378
Query: 216 AEREYTAVLQEYSELERQLCE-MEACRLRVQELEAELLELQQMKQ 259
E + +E E +++L + ++ V+ + ++ L++ KQ
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQ 1423
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 52.0 bits (123), Expect = 1e-06
Identities = 68/282 (24%), Positives = 129/282 (45%), Gaps = 35/282 (12%)
Query: 8 EDFSAEEEESWYDQ---QDLEQDLHLAAELGKTLLERNKELEG----------SLQQMYS 54
E + +EE+ + Q Q L+ +L + +L + + + G + Q++++
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 55 TNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKA----AQQ 110
+E Q +E+ L K L+ + E + +Q L ARD + +L+SK A +
Sbjct: 273 EHERQAKELFLLRKTLEEM----ELRIETQKQT-LNARDESIKKLLEMLQSKGLSAKATE 327
Query: 111 KIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERR-RTIHTFPCLKELCTSPR 169
+ H T + + V L++ +EQ ++ +LRE+ RR K L T
Sbjct: 328 EDHERTRRLAEAEMHVHHLESLLEQKE--KENSMLREEMHRRFENAPDSAKTKALQTVIE 385
Query: 170 CKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYT-----AVL 224
KD+ SS+E G R LE+E + L++ GAL ++ +E ++ R ++ V
Sbjct: 386 MKDS---KISSMERGLRDLEEEIQMLKS-NGALSTEEREEEMKQMEVYRSHSKFMKNKVE 441
Query: 225 QEYSELERQLCEMEACRLRVQELEAELLEL-QQMKQAKTYLL 265
Q EL + + E + + L+AE+ ++ Q++ + T LL
Sbjct: 442 QLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
Score = 35.4 bits (80), Expect = 0.11
Identities = 50/242 (20%), Positives = 108/242 (44%), Gaps = 28/242 (11%)
Query: 23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAK 82
DL++ A G R K LE +L+Q +E+ ++E K+ H A+
Sbjct: 677 DLKEHASSLASSGLKKDSRLKTLEIALEQ----KKEECLKMESQLKKA----HEAALEAR 728
Query: 83 VYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQL 142
++ + LE R ES AQ ++ L E ++ ++ + + ++ +L
Sbjct: 729 ASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE----- 783
Query: 143 RVLREKRERRRTIHTFPCLKELCTSPRCKDAFR----LHSSSLELGPRPLEQENERLQTL 198
R ++++ ++ + +++ ++ ++A R L+ SS +L L ++++R++ L
Sbjct: 784 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRIEEL 842
Query: 199 VGALRSQV----------SQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELE 248
ALR V +QE + AE++ +L +++++L M+A Q+
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 249 AE 250
AE
Sbjct: 903 AE 904
Score = 34.3 bits (77), Expect = 0.25
Identities = 46/224 (20%), Positives = 91/224 (40%), Gaps = 31/224 (13%)
Query: 43 KELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLV 102
++LE +Q + S +E E KQ++ R ++ EQL E L
Sbjct: 399 RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK 458
Query: 103 LESKAAQQKIHGLTETIERLQAQVEELQAQVEQLR-----GLEQLRVLRE----KRERRR 153
++ Q +I + + + R ++ LQ ++E L + + VL+E K +R
Sbjct: 459 KKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 518
Query: 154 TIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLV---GALRSQVSQER 210
+ T DA RL LE L ++ +++Q + G ++ +
Sbjct: 519 ILQTE------------VDALRLR---LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 563
Query: 211 QRKERAEREYTAVLQEYSELERQL----CEMEACRLRVQELEAE 250
+ ER+ + ++ L+ QL +M + + RV+ L+A+
Sbjct: 564 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD 607
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 52.0 bits (123), Expect = 1e-06
Identities = 66/282 (23%), Positives = 127/282 (45%), Gaps = 33/282 (11%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEY-LTKQLDTLRHVNEQHA- 81
LE+DL + GK LL + + + LQ+ ++ E++ +E +T QL ++ EQ
Sbjct: 651 LEEDL----KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEA 706
Query: 82 -------------KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIER----LQA 124
K+YE ++ + + +LE + +QK+ L E+ L
Sbjct: 707 EHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDC 766
Query: 125 QVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELG 184
+++ Q ++ +L L+Q VL E R T+ ++ C + ++L++
Sbjct: 767 DLKQSQQKINEL--LKQKDVLNED-VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMS 823
Query: 185 PRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRV 244
+ L+QEN L + L Q ++ R+ ++ A+ + LQ+ E E+ + + +V
Sbjct: 824 EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKE-LQDQLEAEQYFSTL--YKTQV 880
Query: 245 QELEAELLEL----QQMKQAKTYLLGPDDHLAEALLAPLTQA 282
+EL+ E E ++++Q K L D LA L LT+A
Sbjct: 881 RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKA 922
Score = 33.5 bits (75), Expect = 0.42
Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 35/268 (13%)
Query: 17 SWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHV 76
++Y + L D E +N+E + +++Y+ E +L+ ++ +
Sbjct: 414 TYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEE-------HLSNEMQAKEEL 466
Query: 77 NEQHAKVYEQLDLTARDLE---------------LTNHRLVLESKAA--QQKIHGLTETI 119
++ V +L+ TA++LE L + +L+ K A Q+K +
Sbjct: 467 EQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKK 526
Query: 120 ERLQAQVEELQAQVEQLRGL---EQLRVLREKRERRRTIHTFPCLK-ELCTSPRCKDAFR 175
L+ V L+ Q+E L+ Q+ + + +R+ T L+ E T+ R +
Sbjct: 527 RNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQA 586
Query: 176 LHS---SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELER 232
S LE R L+ +N L+T L + + E R+ T + ++L+
Sbjct: 587 ESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQG 646
Query: 233 QLCEMEA----CRLRVQELEAELLELQQ 256
++C +E ++ + ++E E +LQ+
Sbjct: 647 RICGLEEDLKNGKILLAKVELEKRQLQE 674
Score = 32.3 bits (72), Expect = 0.94
Identities = 57/266 (21%), Positives = 113/266 (42%), Gaps = 30/266 (11%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQ-------EIEYLTKQLDTLRHV 76
L+ DL + + LL++ L ++ + E++ Q +++ T+Q++TL+
Sbjct: 764 LDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMS 823
Query: 77 NEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQ-------AQVEEL 129
+Q + L +LE N L E + A ++ L + +E Q QV EL
Sbjct: 824 EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVREL 883
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLE 189
+ + E+ L + + ++K+E + + E+ + D+ +L S E LE
Sbjct: 884 KEECEEKTKLGK-ELQQKKQELQDERDSLAAQLEITLTK--ADSEQLARSIAEEQYSDLE 940
Query: 190 QENERLQTLVGALRSQVSQERQRK-------ERAEREYTA----VLQEYSELERQLCEM- 237
+E + + + ++ QE K E R T+ + E EL +L ++
Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQ 1000
Query: 238 -EACRLRVQELEAELLELQQMKQAKT 262
+ RL+ +E+ A ++ Q KQ T
Sbjct: 1001 EQLSRLKDEEISAAAIKAQFEKQLLT 1026
Score = 31.2 bits (69), Expect = 2.1
Identities = 93/502 (18%), Positives = 190/502 (37%), Gaps = 92/502 (18%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT---LRHVN 77
+++LE D++ + + L +RN+ + S +++ + + L + DT LR
Sbjct: 526 KRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQ 585
Query: 78 EQHAKVYEQLDLTARDL----------------ELTNHRLVLESKAA------------Q 109
+ +K +QL+ RDL E N + LES+ Q
Sbjct: 586 AESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQ 645
Query: 110 QKIHGLTETIER---LQAQVEELQAQV-EQLRGLE------------QLRVLREKRERRR 153
+I GL E ++ L A+VE + Q+ E+ LE QL+V+++ E+
Sbjct: 646 GRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEE 705
Query: 154 TIHTFPCLKELCTSPRCKDAFRLHSSSLE-------------LGPRPLEQENERL----Q 196
H T R D +++ S E L R L+Q+ E L +
Sbjct: 706 AEHK-------ATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAE 758
Query: 197 TLVGALRSQVSQERQRKERAEREYTAVLQEY--------SELERQLCEMEACRLRVQELE 248
L + Q +Q+ ++ + ++ E +++ +++ Q++
Sbjct: 759 KRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVN 818
Query: 249 AELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAAS 308
+ +Q+KQ +L+ +L + + +AD D L A+ S+ +
Sbjct: 819 TLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKT 878
Query: 309 PGHVVRKSCSD-TALNAIVAKDPA----SRHAGNLTLHANSVRKRGMSILREVDEQYHAL 363
+++ C + T L + + R + L + + R + E+ ++
Sbjct: 879 QVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSD 938
Query: 364 LEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVE 423
LEK E+++ + RH T +D++ L EE + + +L+ E
Sbjct: 939 LEK-EKIMKELEIKEMMARHKQELT----EKDATIASL---EETNRTLTSDVANLANEKE 990
Query: 424 AVDKRLEQSQPEYKALFKEIFS 445
++ +L+ Q + L E S
Sbjct: 991 ELNNKLKDVQEQLSRLKDEEIS 1012
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 52.0 bits (123), Expect = 1e-06
Identities = 66/251 (26%), Positives = 109/251 (43%), Gaps = 32/251 (12%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQH 80
+++ + ++HL +LG++L + + L +V++++ D H+ ++
Sbjct: 120 KEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQ------DETNHLRKEL 173
Query: 81 AKVYEQLDLTARD---LELTNHRLVLESKAAQQKIH----GLTETIERLQAQVEELQAQV 133
V QL + L L N R + ++++H L E ERL Q E L Q
Sbjct: 174 ESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLCEQE 233
Query: 134 EQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENE 193
E+LR EQ LRE+ ER C +E C+ RL G L +E E
Sbjct: 234 ERLR--EQEERLREQEERLHEQEERLCEQE---ERLCEQEERLCEQEKLPGQERLLEEVE 288
Query: 194 RLQTLVGALRSQVSQERQRKERAER--EYTAVLQEYSE-LERQLCEMEACRLRVQELEAE 250
+L + QER R+E ER E +L E E LE++ + RL QE E
Sbjct: 289 KL----------LEQER-RQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRE 337
Query: 251 LLELQQMKQAK 261
L L+++++ +
Sbjct: 338 LERLRELERLR 348
Score = 35.8 bits (81), Expect = 0.085
Identities = 64/240 (26%), Positives = 101/240 (42%), Gaps = 43/240 (17%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGS--LQQMYSTNEEQVQEIEYLTKQLDTLRHVNE 78
+Q ++ HL EL + E+E + L + EE+++E E ++E
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQE---------ERLHE 210
Query: 79 QHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRG 138
Q +++EQ + E RL + + +++ L E ERL Q E L Q E+L
Sbjct: 211 QEERLHEQEERLCEQEE----RLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCE 266
Query: 139 LEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ----ENER 194
E+ +EK + + L+E+ LE R EQ E ER
Sbjct: 267 QEERLCEQEKLPGQERL-----LEEV-------------EKLLEQERRQEEQERLLERER 308
Query: 195 LQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLEL 254
L V L Q +Q + ++E L+ ELER L E+E R++ELE +LEL
Sbjct: 309 LLDEVEELLEQERLRQQDERLWQQETLRELERLRELER-LRELE----RLRELE-RMLEL 362
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 51.6 bits (122), Expect = 1e-06
Identities = 77/317 (24%), Positives = 141/317 (44%), Gaps = 56/317 (17%)
Query: 14 EEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQ--QMYSTNEEQVQEIEYLTKQLD 71
+E+ QQ + A E + +L++ ++L+ +Q Q+ +EQ+Q+ + L +Q +
Sbjct: 165 QEQQRLQQQQEQLQTQQAQE--QQVLQQQEQLQQQVQEQQLLQQQQEQLQQ-QQLLQQQE 221
Query: 72 TLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEE--L 129
L+ +Q + EQL + L L + + QQ+ + +E+ QAQ+++ L
Sbjct: 222 QLQQ--QQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLL 279
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLE 189
Q EQL+ +Q ++L++++E+ + +L P PLE
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQLQ--------------------------QQQLQPPPLE 313
Query: 190 QENER---LQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQE 246
E E L+ + L S+ E+QR+E ++ QE +L+ +L E +Q+
Sbjct: 314 PEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQE------ELQQ 367
Query: 247 LEAEL-LELQQMKQAKTYL------LGPDDHLAEALLAPLTQAPEAD-DPQPGRGDDLGA 298
LE +L + QQ++Q + L LG + L P+ PE + P G A
Sbjct: 368 LEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPV--QPELQLELVPAAGGGGAA 425
Query: 299 QDGVSSP--AASPGHVV 313
G + A PG+VV
Sbjct: 426 VPGAPAAVVVAPPGYVV 442
Score = 46.2 bits (108), Expect = 6e-05
Identities = 56/250 (22%), Positives = 111/250 (44%), Gaps = 51/250 (20%)
Query: 49 LQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAA 108
LQQ E Q Q + +QL L+ E+H V+ Q +L+L + + L+ +
Sbjct: 109 LQQPQPHLELQQQPQQDGQQQLSQLQQ--EKHQSVHHQE--LKPELQLMHQQQQLQPQQV 164
Query: 109 QQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSP 168
Q++ +RLQ Q E+LQ Q Q + +VL+++ + ++ + L++
Sbjct: 165 QEQ--------QRLQQQQEQLQTQQAQ-----EQQVLQQQEQLQQQVQEQQLLQQ----- 206
Query: 169 RCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYS 228
+L + L Q+ E+LQ Q ++Q+++ +++ +LQ+
Sbjct: 207 ----------QQEQLQQQQLLQQQEQLQ--------QQQFQQQQEQLQQQQQLLLLQQQG 248
Query: 229 ELERQLCEMEACRLRVQELEAELLELQ-----------QMKQAKTYLLGPDDHLAEALLA 277
+L++QL + + +L+ Q LE + +LQ Q +Q + L + L + L
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQ 308
Query: 278 PLTQAPEADD 287
P PE ++
Sbjct: 309 PPPLEPEEEE 318
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 51.6 bits (122), Expect = 1e-06
Identities = 102/470 (21%), Positives = 170/470 (36%), Gaps = 70/470 (14%)
Query: 25 EQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVY 84
E++ AEL + L + N E+ + + ++ +E+E K+L E+
Sbjct: 1397 EEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV--- 1453
Query: 85 EQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQ--L 142
E + LE RL ES+ ++ T L + L+ +E+ R E+
Sbjct: 1454 EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQ 1513
Query: 143 RVLREKRERRRTIHTFPCLKELCTSPRCKDAFRL---HSSSLELGPRPLEQENERLQTLV 199
R L + R + T + FRL H +LE L++EN+ LQ +
Sbjct: 1514 RELEAAQRESRGLGT--------------ELFRLRHGHEEALE-ALETLKRENKNLQEEI 1558
Query: 200 GALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEME-ACRLRVQELEAELLELQQMK 258
L QVS + + E+ A+ E SE++ L E E A L + LEL Q+K
Sbjct: 1559 SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK 1618
Query: 259 QAKTYLLGPDDH-----------LAEALLAPL-------TQAPEADDPQPGRGDDLGAQD 300
L D E+L A L +A G +DL Q
Sbjct: 1619 AEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQL 1678
Query: 301 GVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY 360
G ++ A+ + +D R A L A ++ +R + E++E
Sbjct: 1679 GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELR 1738
Query: 361 HAL-------------LEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEG 407
AL L + E L+ G+ + + +++ S + E
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERR 1798
Query: 408 QGEVKAG---------------EKSLSQHVEAVDKRLEQSQPEYKALFKE 442
+ E KA E+ S H+E + K LEQ+ E +A +E
Sbjct: 1799 EAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848
Score = 51.2 bits (121), Expect = 2e-06
Identities = 98/512 (19%), Positives = 199/512 (38%), Gaps = 79/512 (15%)
Query: 20 DQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEY-------LTKQLDT 72
+ +D+ +L A L ++ + LE +L++ EE +E+E L +L
Sbjct: 1473 ESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 73 LRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQ 132
LRH +E+ + E L ++L+ L + + + I L +T + L+ + E+QA
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 133 VEQLRG---LEQLRVLRE-------------------------KRERRRTIHTFPCLKEL 164
+E+ G LE+ + LR +R +R + + +
Sbjct: 1593 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 1652
Query: 165 CTSPRCKDAFRLHS------SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAER 218
T R +A RL + LEL ++ Q +++Q+ +E+ ++ +R
Sbjct: 1653 ETRAR-NEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQR 1711
Query: 219 EYTAVLQEYSELERQL----CEMEACRLRVQE-------LEAELLE----LQQMKQAKTY 263
+ ++ LER+ E+E R +++ E ELLE L + T
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG 1771
Query: 264 LLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALN 323
LL L EA LA L+ E + Q R + A+ ++ A + ++ DT+ +
Sbjct: 1772 LLNQKKKL-EADLAQLSGEVE-EAAQERREAEEKAKKAITDAAMMAEELKKEQ--DTSAH 1827
Query: 324 AIVAKDPASRHAGNLTLHANSVRKRGM-----------SILREVDEQYHALLEKYEELLS 372
K + L + + + +RE++ + A +K+ E L
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 373 KCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQS 432
R+H V+ Q + +DL ++++ KS + E +++ +
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDL------VDKLQSKVKSYKRQFEEAEQQANTN 1941
Query: 433 QPEYKALFKEIFSRIQKT-KADINATKVKTHS 463
+Y+ E+ ++ A+ A K++ +
Sbjct: 1942 LAKYRKAQHELDDAEERADMAETQANKLRART 1973
Score = 44.7 bits (104), Expect = 2e-04
Identities = 59/268 (22%), Positives = 116/268 (43%), Gaps = 32/268 (11%)
Query: 13 EEEESWYDQQDLEQDLHLAA-ELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQL- 70
E E D++++ DL +L E K+++ L+ + E++ Q E K L
Sbjct: 970 ELSERLEDEEEVNADLAARRRKLEDECTELKKDID-DLKLTLAKAEKEKQATENKVKNLT 1028
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ + ++E A++ ++ + L+ + + + + +A + ++ LT+ RL+ QVE+L+
Sbjct: 1029 EEMAALDESVARLTKE----KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLE 1084
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAF--RLHSSSLELGPRPL 188
+EQ + +LR+ E+ +R+ + + + + K +L EL L
Sbjct: 1085 CSLEQEK---KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSL 1141
Query: 189 EQENER------------LQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCE 236
E+E+ LQ L ++ ER + R E++ +E EL +L E
Sbjct: 1142 RVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEE 1201
Query: 237 --------MEACRLRVQELEAELLELQQ 256
E CR R EL EL++
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEE 1229
Score = 43.9 bits (102), Expect = 3e-04
Identities = 88/447 (19%), Positives = 172/447 (38%), Gaps = 34/447 (7%)
Query: 32 AELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTA 91
AELG+ E + + + +Q + L +Q+D+L+ V ++ K +L +
Sbjct: 1218 AELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEV 1277
Query: 92 RDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRER 151
DL L +A++ + + + +VEELQ Q+ ++ R+ E E
Sbjct: 1278 DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD-ASTQRGRLQTESGEL 1336
Query: 152 RRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQ 211
R + CL + + L + SLE R LE+E++ L A+++
Sbjct: 1337 SRLLEEKECLISQLSRGKA-----LAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 212 RKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELL----ELQQMKQAKTYLLGP 267
+E+ E E A + L + E+ R + EA+ + EL++ K+ L
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWR---SKYEADAIQRTEELEEAKKKLALRLQE 1448
Query: 268 DDHLAEALLAPLTQAPEADDPQPGRGDD--LGAQDGVSSPAA---SPGHV-----VRKSC 317
+ EA A + +A +D L + S+ AA H+ R+
Sbjct: 1449 AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQ 1508
Query: 318 SDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQH 377
+ + A SR G + + L + + L E+ +L +
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 378 GAGVRHAGVQTSRPISRDSSWRDLRGG-EEGQGEVKAGEK-------SLSQHVEAVDKRL 429
G ++ +T + + + S +++ EE +G ++ E LSQ VD++L
Sbjct: 1569 GKSIQEL-EKTKKALEGEKS--EIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKL 1625
Query: 430 EQSQPEYKALFKEIFSRIQKTKADINA 456
+ E L + ++ +A ++A
Sbjct: 1626 AEKDEECANLRRNHQRAVESLQASLDA 1652
Score = 38.1 bits (87), Expect = 0.017
Identities = 61/275 (22%), Positives = 114/275 (41%), Gaps = 41/275 (14%)
Query: 13 EEEESWYDQQDLEQDLHLAAEL----GKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTK 68
EE+ ++Q L +LH A+ L +EL +L+Q + QE+ T+
Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATE 1760
Query: 69 QLDTLRHVN----EQHAKVYEQLDLTARDLE----------------LTNHRLVLESKAA 108
+L+ L N Q K+ L + ++E +T+ ++ E
Sbjct: 1761 RLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK 1820
Query: 109 QQKIHGLTETIER-LQAQVEELQAQVEQLR------GLEQLRVLREK-RERRRTIHTFPC 160
+Q E +++ L+ V ELQA++E+ G +Q++ L K RE +
Sbjct: 1821 EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDA--- 1877
Query: 161 LKELCTSPRCKDAFRLHSSSLELGPRPLEQENE---RLQTLVGALRSQVSQERQRKERAE 217
E R H ++ E++ + R+Q LV L+S+V +++ E AE
Sbjct: 1878 --EQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAE 1935
Query: 218 REYTAVLQEYSELERQLCEMEACRLRVQELEAELL 252
++ L +Y + + +L + E R + E +A L
Sbjct: 1936 QQANTNLAKYRKAQHELDDAEE-RADMAETQANKL 1969
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 50.8 bits (120), Expect = 3e-06
Identities = 64/272 (23%), Positives = 124/272 (45%), Gaps = 34/272 (12%)
Query: 8 EDFSAEEEESWYDQ---QDLEQDLHLAAELGKTLLERNKELEG----------SLQQMYS 54
E + +EE+ + Q Q L+ +L + +L + + + G + Q++++
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 55 TNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKA----AQQ 110
+E Q +E+ L K L+ + E + +Q L ARD + +L+SK A +
Sbjct: 273 EHERQAKELFLLRKTLEEM----ELRIETQKQT-LNARDESIKKLLEMLQSKGLSAKATE 327
Query: 111 KIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERR-RTIHTFPCLKELCTSPR 169
+ H T + + V L++ +EQ ++ +LRE+ RR K L T
Sbjct: 328 EDHERTRRLAEAEMHVHHLESLLEQKE--KENSMLREEMHRRFENAPDSAKTKALQTVIE 385
Query: 170 CKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVL----- 224
KD+ SS+E G R LE+E + L++ GAL ++ +E ++ R ++ +
Sbjct: 386 MKDS---KISSMERGLRDLEEEIQMLKS-NGALSTEEREEEMKQMEVYRSHSKFMKNKIG 441
Query: 225 QEYSELERQLCEMEACRLRVQELEAELLELQQ 256
Q EL R+ E+ A + +++ L + + +Q
Sbjct: 442 QVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
Score = 35.4 bits (80), Expect = 0.11
Identities = 50/242 (20%), Positives = 108/242 (44%), Gaps = 28/242 (11%)
Query: 23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAK 82
DL++ A G R K LE +L+Q +E+ ++E K+ H A+
Sbjct: 649 DLKEHASSLASSGLKKDSRLKTLEIALEQ----KKEECLKMESQLKKA----HEAALEAR 700
Query: 83 VYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQL 142
++ + LE R ES AQ ++ L E ++ ++ + + ++ +L
Sbjct: 701 ASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE----- 755
Query: 143 RVLREKRERRRTIHTFPCLKELCTSPRCKDAFR----LHSSSLELGPRPLEQENERLQTL 198
R ++++ ++ + +++ ++ ++A R L+ SS +L L ++++R++ L
Sbjct: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRIEEL 814
Query: 199 VGALRSQV----------SQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELE 248
ALR V +QE + AE++ +L +++++L M+A Q+
Sbjct: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874
Query: 249 AE 250
AE
Sbjct: 875 AE 876
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.8 bits (120), Expect = 3e-06
Identities = 67/264 (25%), Positives = 114/264 (43%), Gaps = 47/264 (17%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT 72
E E+ + ++++L+Q+ E ER K ++ Y +E QE E L ++
Sbjct: 985 EREKKYREEEELQQE-----EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 73 LRHVNEQHAKVYEQLDLTARDLEL------TNHRLVLE------SKAAQQKIHGLTETIE 120
R + E+ + E+ +L + +L T R LE + Q++ L E E
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 121 RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS 180
+ + Q E Q + E+ E+ ++LRE+RE+RR +EL R ++
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRR-------QELERQYREEE-------- 1144
Query: 181 LELGPRPLEQENERLQTLVGALRSQ-VSQERQRKERAEREYTAVLQEYSELERQLCEMEA 239
++QE E+L LR + + RQ ER RE + QE +L R+ E E
Sbjct: 1145 ------EVQQEEEQL------LREEPEKRRRQELERQYREEEELQQEEEQLLRE--EQEK 1190
Query: 240 CRLRVQELEAELLELQQMKQAKTY 263
R + E ELQ+ K+ + Y
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRY 1214
Score = 49.7 bits (117), Expect = 6e-06
Identities = 68/257 (26%), Positives = 108/257 (42%), Gaps = 43/257 (16%)
Query: 40 ERNKELEGSLQQMYSTNEEQVQEIE---YLTKQLDTLRHVNEQHAKVYEQLDLTAR---D 93
ER KEL+ + EEQ+Q E L ++ D L+ E+ ++ D R +
Sbjct: 826 EREKELQ------FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 94 LELTNHRLVLESKAA--------QQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLR-- 143
E R L +K A QQ + E ++R + + Q Q Q R EQL+
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 144 ---VLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRP---LEQENERLQT 197
+LRE+RE+RR ++ KD LG P QE E+
Sbjct: 940 EEQLLREEREKRR--------RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 198 LVGALRSQVSQ------ERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAEL 251
L+ + Q E++R++ ER+Y E + E QL E + R+QE E +
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRK-KDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 252 LELQQMKQAKTYLLGPD 268
E ++++Q + LLG +
Sbjct: 1051 REEEELQQEEEQLLGEE 1067
Score = 44.7 bits (104), Expect = 2e-04
Identities = 69/297 (23%), Positives = 119/297 (40%), Gaps = 46/297 (15%)
Query: 1 MRRAAGMEDFSAEEEESWYDQQDL-----EQDLHLAAELGKTLLE----RNKELEGSL-- 49
+RR G + E + + + + L EQ LH K L E R +E E L
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 50 ---------QQMYSTNEEQV-----------QEIEYLTKQLDTLRHVNEQHAKVYEQLDL 89
+Q+ EEQ +E + L +Q + + E+ ++L+
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 90 TARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQ-VEQLRGLEQLRVLREK 148
R+ E E Q++ + E E+L+ + EE Q + E+ R + LR++
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEE-EQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 149 RERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQEN----ERLQTLVGALRS 204
RE ++ L+ + + ++ +L E RP +++ E Q +
Sbjct: 1783 REEQQ-------LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 205 QVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAK 261
++ QER R+ RAE ++ QE S E Q E + R QE E +L E +Q K
Sbjct: 1836 RLRQERDRQYRAEEQFAT--QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890
Score = 40.4 bits (93), Expect = 0.003
Identities = 62/267 (23%), Positives = 110/267 (41%), Gaps = 47/267 (17%)
Query: 15 EESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLR 74
E+ +Q L ++ L E + E+ E E Q++ EQ + ++L ++ +T R
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL---KREQEERRDWLKREEETER 466
Query: 75 HVNE---QHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETI--ERLQAQVEEL 129
H E Q K ++ + R L+L + + +Q++ E +RL+ Q EE
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLE 189
+ Q ++LR +QLR RE+ ERR + LK
Sbjct: 527 RLQ-QRLRSEQQLR--REQEERREQL-----LKR-------------------------- 552
Query: 190 QENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEA 249
+E +RL+ R + QE +R + +RE Q + + E R V+ LE
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 250 ELLELQQMKQAKTYLLGPDDHLAEALL 276
E Q++K+ + P++ + LL
Sbjct: 613 EERREQRLKREE-----PEEERRQQLL 634
Score = 38.5 bits (88), Expect = 0.013
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 38/259 (14%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT 72
EEEE Q+ EQ L E + + +E E LQQ + ++ +E E +QL
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-- 549
Query: 73 LRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQ 132
L+ E+ + + R+ E +L+ + +Q + ++R Q + E + +
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ------QRLKREQEERLEQRLK 603
Query: 133 VEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQEN 192
E++ LEQ E+RE+R LK P + +L S EQE
Sbjct: 604 REEVERLEQ----EERREQR--------LKR--EEPEEERRQQLLKSE--------EQEE 641
Query: 193 ERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSE--LERQLCE------MEACRLRV 244
R Q L + + Q +R+E ER + +E+ E E++L E E + R+
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701
Query: 245 QELEAELLELQQMKQAKTY 263
+ + +L +Q+K Y
Sbjct: 702 PKWQWQLESEADARQSKVY 720
Score = 37.7 bits (86), Expect = 0.022
Identities = 63/265 (23%), Positives = 108/265 (40%), Gaps = 27/265 (10%)
Query: 12 AEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLT-KQL 70
AE EE Q+ LEQ + R++EL Q+ E + +E + + K
Sbjct: 149 AEGEEQSEKQERLEQ---------RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH 199
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRL---------VLESKAAQQKIHGLTETIER 121
+T +E+ + E L+L + E + E K +++ L + E+
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 122 LQAQV----EELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLH 177
LQ + ELQ + EQLR LE+ + RE++E + ++L ++
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE-EERREQQ 318
Query: 178 SSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELER-QLCE 236
E R +QE R Q L + Q+ +R++ ER + +E E R Q
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 237 MEACRLRVQEL--EAELLELQQMKQ 259
E R Q+L E +L QQ+++
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRR 403
Score = 37.7 bits (86), Expect = 0.022
Identities = 58/254 (22%), Positives = 105/254 (41%), Gaps = 34/254 (13%)
Query: 20 DQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQ 79
D++ EQ+L + E + LE ++L +Q EEQ + +Q R ++
Sbjct: 1500 DRKFREQELR-SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR---RQDRDR 1555
Query: 80 HAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL 139
+ EQL + +L+ + + +QK+ R Q Q + +QLR
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKV--------RRQEQERKFMEDEQQLRRQ 1607
Query: 140 EQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTL- 198
E + LR++R+R+ F ++L + R L P + ER Q L
Sbjct: 1608 EGQQQLRQERDRK-----FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 199 ---------VGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCE----MEACRLRVQ 245
L + +++ R++ +R++ +E +L RQ E E +LR Q
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFR---EEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 246 ELEAELLELQQMKQ 259
ELE + E +Q++Q
Sbjct: 1720 ELERKFREEEQLRQ 1733
Score = 37.0 bits (84), Expect = 0.038
Identities = 70/296 (23%), Positives = 109/296 (36%), Gaps = 52/296 (17%)
Query: 2 RRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQ 61
RR E EEEE +++ L ++ ER K L++ Y EE Q
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLRE------------EREKRRRQELERQYREEEEVQQ 1148
Query: 62 EIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIER 121
E E L ++ R E + E+ +L + +L + K Q++ E E
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE---QEKRRQERERQYREE-EE 1204
Query: 122 LQAQVEELQAQVEQLRG-------------------------LEQLRVLREK--RERRRT 154
LQ Q + + + E R EQ R L + R+R+
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264
Query: 155 IHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKE 214
L E R ++ R P E++ ER + R + SQE ++
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHF---PEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 215 RAEREYTAVLQE----YSELERQLCEMEACRLRVQELEAELL--ELQQMKQAKTYL 264
R ERE QE + E E+ L E E LR QE + + EL+ +Q + +L
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Score = 29.3 bits (64), Expect = 7.9
Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 26/271 (9%)
Query: 2 RRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQ 61
R++ + EE E +Q+ ++ +L L ER ++ ++ EE+++
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQL---LQEREEQPLRRQERDRKFREEELR 1368
Query: 62 EIEYLTKQLDTLRHVNEQHA-----KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLT 116
E K L+ + + Q K +QL R+ +L R + QQ
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR--Q 1426
Query: 117 ETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRL 176
E + + + ++++ Q + + LE+ + LR++R R+ +E + ++ +L
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK--------FREEEQLLQEREEQQL 1478
Query: 177 HSSSLELGPRPLEQENE-RLQTLVGALRSQV--SQERQRKERAEREYTAVLQ---EYSEL 230
H E + LE+E + R Q R Q SQE +RK E + Q ++ +
Sbjct: 1479 HRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 231 ERQLCEMEACRLRVQELEAELLELQQMKQAK 261
E+QL E + R Q+ + + E +Q++Q +
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 50.8 bits (120), Expect = 3e-06
Identities = 99/461 (21%), Positives = 186/461 (40%), Gaps = 82/461 (17%)
Query: 11 SAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQL 70
S E+E S D+++LE + +E K + Q+ N+E E E L K L
Sbjct: 691 SLEKENSQLDEENLEL---------RRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ L+ K E+L+++ + L++ N RL + + +KI L ++ L+ + + LQ
Sbjct: 742 ELLK----ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ 190
+E+L+ + R+ + ++E + + +S LE + LE+
Sbjct: 798 KNLEELK-ISSKRLEQLEKENK--------------------SLEQETSQLEKDKKQLEK 836
Query: 191 ENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAE 250
EN+RL+ + + + + E+E + +E + E+C +R++ELE E
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK------ESC-VRLKELEKE 889
Query: 251 LLELQQMK--QAKTYLLGPDDHLAEAL--------LAPLTQAPEADDPQPGR--GDDLGA 298
EL + KT + +D ++E L L LT E R D+
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 299 QDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDE 358
D S K + I A + + N + +R+ L+ V +
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN---YNQQLRQE----LKTVKK 1002
Query: 359 QYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPIS-RDSSW--------RDLRGGEEGQG 409
Y AL ++ +E VQ+S PIS D+ W R+L ++
Sbjct: 1003 NYEALKQRQDE-------------ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 410 EVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKT 450
EV+ +L +A+ +L+Q + + L +I + ++T
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Score = 50.1 bits (118), Expect = 4e-06
Identities = 63/268 (23%), Positives = 121/268 (45%), Gaps = 51/268 (19%)
Query: 13 EEEESWYDQ--QDLEQDLHLAAELG-KTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQ 69
E+E +Q L Q ++AE K + + NK L S+++ S ++ +IE+ +Q
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS----KLSKIEFEKRQ 612
Query: 70 LDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEEL 129
+ ++ + Y++ A +LE H L E++ Q+KI L T E+++A +E+
Sbjct: 613 I-------KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQE 664
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLK------------------ELCTSPRCK 171
+++E RE R+ ++T+ +F L EL +
Sbjct: 665 NSELE-----------RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 172 DAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELE 231
+ + L+L + LE E E+L+ + L++ ++ ER E Y + E L+
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASF----KKTERLEVSYQGLDIENQRLQ 769
Query: 232 RQLCEMEACRLRVQELEAELLELQQMKQ 259
+ L E ++Q+LE+EL +L+ Q
Sbjct: 770 KTL---ENSNKKIQQLESELQDLEMENQ 794
Score = 46.6 bits (109), Expect = 5e-05
Identities = 53/236 (22%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 22 QDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
++L++D + E KT+LE +LEG+ + +E + + ++ L +L + +
Sbjct: 347 EELKEDNQVLLET-KTMLE--DQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDR 402
Query: 82 KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQ 141
K E+L LE+ + + ES ++ ++ T E +A + L +V +L
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 142 LRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGA 201
L++ E + +T+ +EL T+ D+ ++S + +E+EN+RL V
Sbjct: 463 LKLEMENQSLTKTV------EELRTTV---DSVEGNASKI----LKMEKENQRLSKKVEI 509
Query: 202 LRSQVSQERQRKERAEREYTAVLQEYSELERQLCEM-EACRLRVQELEAELLELQQ 256
L +++ QE+Q + + +++E ++LE+ + + E +++ LE E L Q
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Score = 45.8 bits (107), Expect = 8e-05
Identities = 54/231 (23%), Positives = 108/231 (46%), Gaps = 35/231 (15%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQH 80
+Q +++ LHL EL + + R EL + Q+ ++ L +++ N+
Sbjct: 420 KQSMDESLHLGWELEQ--ISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-----NQSL 472
Query: 81 AKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLE 140
K E+L T +E +++ K Q+ L++ +E L+ ++ + + ++ + L
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQR----LSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 141 QLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVG 200
+ +++EK + +TI T L+E + E + LEQENE L V
Sbjct: 529 K-DLMKEKAQLEKTIET---LRE----------------NSERQIKILEQENEHLNQTVS 568
Query: 201 AL--RSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRV-QELE 248
+L RSQ+S E + K+ E+E + + E +L ++E + ++ +ELE
Sbjct: 569 SLRQRSQISAEARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/280 (21%), Positives = 116/280 (41%), Gaps = 37/280 (13%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLH--LAAELGKTL---LERNKE----LEGSLQQMYSTNE 57
+E +E +D+Q + + L ++L TL LE +E LE L++ + N+
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 58 EQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARD-----------------------L 94
+ QE++ + K + L+ ++ V ++ D +
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 95 ELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRT 154
E N L E +A + ++ L LQAQ+ LQ Q L+ EQ L+ + + +
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ--EQNTTLQTQNAKLQV 1109
Query: 155 IHTFPCLKELCTSPRCKDA-FRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRK 213
++ L TS ++A + SSLE + +E E L++L +L +
Sbjct: 1110 ENS--TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167
Query: 214 ERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLE 253
ER EY +++ ++ L+ +E +++ +LL+
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1207
Score = 39.7 bits (91), Expect = 0.006
Identities = 42/194 (21%), Positives = 86/194 (44%), Gaps = 21/194 (10%)
Query: 38 LLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELT 97
LL + LE + + E+ + L K + L ++E+ A YE L L+
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187
Query: 98 NHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHT 157
+ L +E + + + + L + + Q+E+L E++ +EQ ++L E +
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQ----KGQLEDL----EKMLKVEQEKMLLENKNHETVAAE 1239
Query: 158 FPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAE 217
+ L C + RL+ + +L +E E LQT L+S ++ + + R E
Sbjct: 1240 YKKL--------CGENDRLNHTYSQL-----LKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286
Query: 218 REYTAVLQEYSELE 231
E++ + ++Y +L+
Sbjct: 1287 AEFSKLKEQYQQLD 1300
Score = 38.9 bits (89), Expect = 0.010
Identities = 62/272 (22%), Positives = 118/272 (43%), Gaps = 33/272 (12%)
Query: 8 EDFSAEEEESWY--DQQDLEQD---LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQE 62
E+ S E+E S D++ LE++ L AE+ T LE N G+L++ N+ +E
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK---ENKTLSKE 872
Query: 63 IEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERL 122
I + L+ + +++ ++ ++ + + L LV E QQ + +E+L
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ----MNNDLEKL 928
Query: 123 QAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLE 182
++E++ GL + R+L +++ + + L E K + + +
Sbjct: 929 THELEKI--------GLNKERLLHDEQSTDDSRYK---LLESKLESTLKKSLEIKEEKIA 977
Query: 183 LGPRPLEQENERLQTLVGALRS-----QVSQERQRKERAEREYTAVLQEYSELERQLCEM 237
LE+ Q L L++ + ++RQ +ER + + E ++ ER+ E
Sbjct: 978 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1037
Query: 238 EACRLRVQ----ELEAELLELQQMKQA-KTYL 264
L+V+ E+E LQ KQA KT L
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 50.4 bits (119), Expect = 3e-06
Identities = 100/463 (21%), Positives = 191/463 (41%), Gaps = 87/463 (18%)
Query: 11 SAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQL 70
S E+E S D+++LE + +E K + Q+ N+E E E L K L
Sbjct: 691 SLEKENSQLDEENLEL---------RRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ L+ K E+L+++ + L++ N RL + + +KI L ++ L+ + + LQ
Sbjct: 742 ELLK----ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ 190
+E+L+ + R+ + ++E + + +S LE + LE+
Sbjct: 798 KNLEELK-ISSKRLEQLEKENK--------------------SLEQETSQLEKDKKQLEK 836
Query: 191 ENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAE 250
EN+RL+ + + + + E+E + +E + E+C +R++ELE E
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK------ESC-VRLKELEKE 889
Query: 251 LLELQQMK--QAKTYLLGPDDHLAEAL--------LAPLTQAPEADDPQPGR--GDDLGA 298
EL + KT + +D ++E L L LT E R D+
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 299 QDGVSSPAASPGHVVRKS--CSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREV 356
D + ++KS + + A+ A+ S T + +R+ L+ V
Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES------TNYNQQLRQE----LKTV 999
Query: 357 DEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPIS-RDSSW--------RDLRGGEEG 407
+ Y AL ++ +E VQ+S PIS D+ W R+L ++
Sbjct: 1000 KKNYEALKQRQDE-------------ERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1046
Query: 408 QGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKT 450
EV+ +L +A+ +L+Q + + L +I + ++T
Sbjct: 1047 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Score = 50.1 bits (118), Expect = 4e-06
Identities = 63/268 (23%), Positives = 121/268 (45%), Gaps = 51/268 (19%)
Query: 13 EEEESWYDQ--QDLEQDLHLAAELG-KTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQ 69
E+E +Q L Q ++AE K + + NK L S+++ S ++ +IE+ +Q
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS----KLSKIEFEKRQ 612
Query: 70 LDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEEL 129
+ ++ + Y++ A +LE H L E++ Q+KI L T E+++A +E+
Sbjct: 613 I-------KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQE 664
Query: 130 QAQVEQLRGLEQLRVLREKRERRRTIHTFPCLK------------------ELCTSPRCK 171
+++E RE R+ ++T+ +F L EL +
Sbjct: 665 NSELE-----------RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 172 DAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELE 231
+ + L+L + LE E E+L+ + L++ ++ ER E Y + E L+
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASF----KKTERLEVSYQGLDIENQRLQ 769
Query: 232 RQLCEMEACRLRVQELEAELLELQQMKQ 259
+ L E ++Q+LE+EL +L+ Q
Sbjct: 770 KTL---ENSNKKIQQLESELQDLEMENQ 794
Score = 46.6 bits (109), Expect = 5e-05
Identities = 53/236 (22%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 22 QDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
++L++D + E KT+LE +LEG+ + +E + + ++ L +L + +
Sbjct: 347 EELKEDNQVLLET-KTMLE--DQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDR 402
Query: 82 KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQ 141
K E+L LE+ + + ES ++ ++ T E +A + L +V +L
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 142 LRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGA 201
L++ E + +T+ +EL T+ D+ ++S + +E+EN+RL V
Sbjct: 463 LKLEMENQSLTKTV------EELRTTV---DSVEGNASKI----LKMEKENQRLSKKVEI 509
Query: 202 LRSQVSQERQRKERAEREYTAVLQEYSELERQLCEM-EACRLRVQELEAELLELQQ 256
L +++ QE+Q + + +++E ++LE+ + + E +++ LE E L Q
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Score = 45.8 bits (107), Expect = 8e-05
Identities = 54/231 (23%), Positives = 108/231 (46%), Gaps = 35/231 (15%)
Query: 21 QQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQH 80
+Q +++ LHL EL + + R EL + Q+ ++ L +++ N+
Sbjct: 420 KQSMDESLHLGWELEQ--ISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-----NQSL 472
Query: 81 AKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLE 140
K E+L T +E +++ K Q+ L++ +E L+ ++ + + ++ + L
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQR----LSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 141 QLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVG 200
+ +++EK + +TI T L+E + E + LEQENE L V
Sbjct: 529 K-DLMKEKAQLEKTIET---LRE----------------NSERQIKILEQENEHLNQTVS 568
Query: 201 AL--RSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRV-QELE 248
+L RSQ+S E + K+ E+E + + E +L ++E + ++ +ELE
Sbjct: 569 SLRQRSQISAEARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Score = 41.2 bits (95), Expect = 0.002
Identities = 55/279 (19%), Positives = 113/279 (40%), Gaps = 36/279 (12%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKE--------LEGSLQQMYSTNEE 58
+E +E +D+Q + L ++ L+++ E LE L++ + N++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
Query: 59 QVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARD-----------------------LE 95
QE++ + K + L+ ++ V ++ D +E
Sbjct: 992 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1051
Query: 96 LTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTI 155
N L E +A + ++ L LQAQ+ LQ Q L+ EQ L+ + + +
Sbjct: 1052 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ--EQNTTLQTQNAKLQVE 1109
Query: 156 HTFPCLKELCTSPRCKDA-FRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKE 214
++ L TS ++A + SSLE + +E E L++L +L + E
Sbjct: 1110 NS--TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1167
Query: 215 RAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLE 253
R EY +++ ++ L+ +E +++ +LL+
Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1206
Score = 39.7 bits (91), Expect = 0.006
Identities = 42/194 (21%), Positives = 86/194 (44%), Gaps = 21/194 (10%)
Query: 38 LLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELT 97
LL + LE + + E+ + L K + L ++E+ A YE L L+
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1186
Query: 98 NHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHT 157
+ L +E + + + + L + + Q+E+L E++ +EQ ++L E +
Sbjct: 1187 HKNLEVEHRDLEDRYNQLLKQ----KGQLEDL----EKMLKVEQEKMLLENKNHETVAAE 1238
Query: 158 FPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAE 217
+ L C + RL+ + +L +E E LQT L+S ++ + + R E
Sbjct: 1239 YKKL--------CGENDRLNHTYSQL-----LKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 218 REYTAVLQEYSELE 231
E++ + ++Y +L+
Sbjct: 1286 AEFSKLKEQYQQLD 1299
Score = 38.9 bits (89), Expect = 0.010
Identities = 63/272 (23%), Positives = 119/272 (43%), Gaps = 34/272 (12%)
Query: 8 EDFSAEEEESWY--DQQDLEQD---LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQE 62
E+ S E+E S D++ LE++ L AE+ T LE N G+L++ N+ +E
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK---ENKTLSKE 872
Query: 63 IEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERL 122
I + L+ + +++ ++ ++ + + L LV E QQ + +E+L
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ----MNNDLEKL 928
Query: 123 QAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLE 182
++E++ GL + R+L +++ T + L+ S K + + +
Sbjct: 929 THELEKI--------GLNKERLLHDEQS---TDDRYKLLESKLES-TLKKSLEIKEEKIA 976
Query: 183 LGPRPLEQENERLQTLVGALRS-----QVSQERQRKERAEREYTAVLQEYSELERQLCEM 237
LE+ Q L L++ + ++RQ +ER + + E ++ ER+ E
Sbjct: 977 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1036
Query: 238 EACRLRVQ----ELEAELLELQQMKQA-KTYL 264
L+V+ E+E LQ KQA KT L
Sbjct: 1037 TRELLKVKDRLIEVERNNATLQAEKQALKTQL 1068
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 50.4 bits (119), Expect = 3e-06
Identities = 73/303 (24%), Positives = 129/303 (42%), Gaps = 48/303 (15%)
Query: 6 GMEDFSAEEEESWYDQQDLEQDLH-LAAELGK--TLLERNKELEGSLQQMYSTNEEQVQE 62
G+ D S EES +LE++ H L+ ++ K T LER K+ S Q + + +EE ++E
Sbjct: 481 GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ---SNQDLETLSEELIRE 537
Query: 63 IEYLTKQLDTLRHVNEQHAKVYEQ-LDLTARDLELTNHRLVLESKAAQQKIH----GLTE 117
E L ++TL+ + K EQ D R + R + S+A + + L +
Sbjct: 538 KEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQ 597
Query: 118 TIERLQAQVEELQAQVEQL-RGLEQLRVLREKRER-RRTIHTFP--------CLKELCTS 167
T+ ++ +L+ + QL R LEQ + E+ E+ R + + L T+
Sbjct: 598 TVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETA 657
Query: 168 PRCKDAFRLHSSSLELGPR------------------------PLEQENERLQTLVGALR 203
+A S L+L R L+ EN L+ LV +R
Sbjct: 658 TEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMR 717
Query: 204 ---SQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQA 260
++++Q + ++ ERE + + L+ + E L Q + AE L LQQ ++
Sbjct: 718 FTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES 777
Query: 261 KTY 263
++
Sbjct: 778 SSH 780
Score = 50.1 bits (118), Expect = 4e-06
Identities = 68/278 (24%), Positives = 118/278 (42%), Gaps = 46/278 (16%)
Query: 23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT--------LR 74
DLE D + + LLE N LE + +Q + + E+E L+K D +
Sbjct: 396 DLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVF 455
Query: 75 HVNEQHAKVYEQLDLTARDLE-----LTNHRLVLESKA-----AQQKIHGLTETIERLQA 124
+NE + +L+ + L+ L + LVLE +++ H L++ IE+LQ
Sbjct: 456 ELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQT 515
Query: 125 QVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPC-----LKELCTSP----RCKDAFR 175
Q+E + + L L + ++REK + + + T +K+L R + R
Sbjct: 516 QLEREKQSNQDLETLSE-ELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLR 574
Query: 176 LHSS-SLELGPRPLEQENERLQTLVGALRSQVSQ-----------------ERQRKERAE 217
S S E + +E+EN+ L V ++SQ + +R E+ E
Sbjct: 575 ERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLE 634
Query: 218 REYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQ 255
RE + +E L R++ +E +V+ LE E LQ
Sbjct: 635 RELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQ 672
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/291 (23%), Positives = 130/291 (44%), Gaps = 43/291 (14%)
Query: 2 RRAAGMEDFSAEEEESWYDQQDLEQDLH-LAAELGKTLLERNKELEGSLQQMYS------ 54
R +D EE +++ L+ D+ L A+ + + + +E + + M+S
Sbjct: 519 REKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578
Query: 55 -TNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIH 113
++E +++++E K L + V E + K+ QL+ R L HR + ++K ++
Sbjct: 579 VSSEARMKDVEKENKALH--QTVTEANGKL-SQLEFEKRQL----HRDLEQAKEKGERAE 631
Query: 114 GLTETIERLQAQ-------VEELQAQVEQLRGLEQLR--VLREKRERRRTIHTFPCLKEL 164
L ++RLQ + V L+ E++ LE + E R R+++ T + L
Sbjct: 632 KLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVS-L 690
Query: 165 CTSPRCKDAFRLHSSSLELGP------------RPLEQENERLQTLVGALRSQVSQER-- 210
+D +L + +LEL +E+EN++L+ LR V +
Sbjct: 691 QLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKAL 750
Query: 211 -QRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQA 260
++ ER E Y +V E L++ L E+ + Q LE+EL EL+ +QA
Sbjct: 751 GKKSERLELSYQSVSAENLRLQQSL---ESSSHKTQTLESELGELEAERQA 798
Score = 44.3 bits (103), Expect = 2e-04
Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 36/243 (14%)
Query: 36 KTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLE 95
+ L+E + L QM N++ +E E L K +D L+ + ++ E+L+L+ + +
Sbjct: 710 RRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKS----ERLELSYQSVS 765
Query: 96 LTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQL-RGLEQLRVLREKRERRRT 154
N RL QQ + + + L++++ EL+A+ + L R LE LR+ + E
Sbjct: 766 AENLRL-------QQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLE---- 814
Query: 155 IHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKE 214
+ + + A + LE + LE+E +RL QV + +
Sbjct: 815 -----------GAEKDRKALEQEVAQLEKDKKLLEKEAKRLW-------QQVELKDAVLD 856
Query: 215 RAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLEL--QQMKQAKTYLLGPDDHLA 272
+ + +AV +E L+++L +++ELE + +L Q A+T +D +
Sbjct: 857 DSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVL 916
Query: 273 EAL 275
E L
Sbjct: 917 EKL 919
Score = 32.7 bits (73), Expect = 0.72
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 13/121 (10%)
Query: 33 ELGKT---LLERNKELEG----------SLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQ 79
ELG+ +L+R ELE +LQQ TN + E + L +LD + ++ Q
Sbjct: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
Query: 80 HAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL 139
YE+L ++L+ + + LE Q + L E + + + +L E L L
Sbjct: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
Query: 140 E 140
+
Sbjct: 1328 K 1328
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/268 (22%), Positives = 124/268 (46%), Gaps = 25/268 (9%)
Query: 7 MEDFSAE-EEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEY 65
++D A +EE WY ++ L+++L L + + + + S ++ S E+Q++E +
Sbjct: 92 VQDLQASLKEEKWYSEE-LKKELEKYQGLQQQEAKPDGLVTDSSAELQSL-EQQLEEAQT 149
Query: 66 LTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQ 125
+ ++ + EQ A QL D++ +AA+QK+ LTE + +
Sbjct: 150 ENFNIKQMKDLFEQKAA---QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATV 206
Query: 126 VEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKD-AFRLHS------ 178
+++L+ ++ Q G+E + VL+++ + +T+ L+ S + KD +L S
Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
Query: 179 -------SSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELE 231
S L GP+ + + LQ L+S V++ Q+ + Q+Y++LE
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322
Query: 232 RQLCEMEACRLRVQ-ELEAELLELQQMK 258
+ E + +Q L + L+ QQ++
Sbjct: 323 EKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Score = 47.0 bits (110), Expect = 4e-05
Identities = 59/269 (21%), Positives = 121/269 (44%), Gaps = 35/269 (13%)
Query: 5 AGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQE-- 62
A +D + EE+ Q+DL + + K L++ K + +L+Q + E+Q+QE
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-LIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 63 --IEYLTKQ--LDTLRHVNE-------QHAKVYEQLDLTARDLELTNHRL-----VLESK 106
++ + K+ L VNE + K ++ ++T + EL +H+L + K
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 107 AAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCT 166
A+Q + + + +E LQ + + L+A VEQ + +Q+ + K+E F
Sbjct: 1163 DAKQLL--IQQKLE-LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF-------- 1211
Query: 167 SPRCKDAFRLHSS--SLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVL 224
+ +LHS E+G + E+ +L + AL + ++ + ++R + +
Sbjct: 1212 ---IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
Query: 225 QEYSELERQLCEMEACRLRVQELEAELLE 253
++ +L ++ +EA Q+ LLE
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLE 1297
Score = 46.2 bits (108), Expect = 6e-05
Identities = 68/274 (24%), Positives = 115/274 (41%), Gaps = 48/274 (17%)
Query: 21 QQDLEQDLHLAAELGK------TLLERNKE----LEGSLQQMYSTNE---------EQVQ 61
Q DLEQ L + + LL+++KE LE + +Y+ + Q+Q
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 62 EI-----EYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKA----AQQKI 112
E E +T+ + L++ +E H + E L H V E KA AQ ++
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENL-----------HDQVQEQKAHLRAAQDRV 616
Query: 113 HGLTETIERLQAQVEELQAQVEQLR-GLEQLRVLREKRERRRTIHTFPCLKELCTSPRCK 171
L ++ L +Q+ E + +V QL ++ L E +T L T+ +
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA---Q 673
Query: 172 DAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELE 231
+A + L L+Q +LQ + SQ + + +Y ++ Q+ ELE
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDK----QEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 232 RQLCEMEACRLRVQ-ELEAELLELQQMKQAKTYL 264
Q+ ++EA L V+ E L +LQQ +Q T L
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/267 (20%), Positives = 116/267 (43%), Gaps = 45/267 (16%)
Query: 22 QDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTN-----------------EEQVQEIE 64
QDL+Q L +L E +K+LE + + ST +Q +E +
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 65 YLTKQLDTL-RHVNEQHAKVYEQLDLTARDLE---LTNHRLVLESKAAQQKIHGLTETIE 120
L + +TL + QH ++ ++ T +L+ + L+ E + K+ ++++++
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
Query: 121 RLQAQVE-----------ELQAQVEQLRGLEQLRV---LREKRERRRTIHTFPCLKELCT 166
+++ E +L+ ++L+ Q+++ L+E++E ++++ KE
Sbjct: 871 NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE-----KEKEA 925
Query: 167 SPRCKDAFRLHSSSLELGPRPL---EQENERLQTLVGALRSQVSQERQRKERAEREYTAV 223
S + K L L E+E ++LQ + L+ Q++++ E + E
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 224 LQEYSELERQLCEMEACRLRVQELEAE 250
+ + +ELE +L + QEL AE
Sbjct: 986 VLQKTELENKL--QQQLTQAAQELAAE 1010
Score = 34.3 bits (77), Expect = 0.25
Identities = 57/256 (22%), Positives = 109/256 (42%), Gaps = 62/256 (24%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT 72
+ +E+ +DQ EQ HL A + L LE S+ ++ S E +++ L Q+
Sbjct: 593 QAQENLHDQVQ-EQKAHLRAAQDRVL-----SLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 73 LRHV--NEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ + + AK ++ DL L + L+ K QQ+++ +T ++++ A++++ Q
Sbjct: 647 KTELLLSAEAAKTAQRADLQNH---LDTAQNALQDK--QQELNKITTQLDQVTAKLQDKQ 701
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ 190
QL L+E +E+ + LEQ
Sbjct: 702 EHCSQLESH-----LKEYKEKYLS---------------------------------LEQ 723
Query: 191 ENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQ-ELEA 249
+ E L+ + L + + + KE+A ++ LQ+ +L L E+ A L Q E+E
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQD----LQQQRQLNTDL-ELRATELSKQLEMEK 778
Query: 250 EL-----LELQQMKQA 260
E+ L+LQ+ +A
Sbjct: 779 EIVSSTRLDLQKKSEA 794
Score = 33.5 bits (75), Expect = 0.42
Identities = 31/160 (19%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 109 QQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSP 168
+Q++ L +++ + EEL+ ++E+ +GL+Q +E + EL +
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQ-------QEAKPDGLVTDSSAELQSLE 141
Query: 169 RCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYS 228
+ + + + +++ EQ+ +L T + ++S+ +ER +E AE++ T + +E +
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN 201
Query: 229 ELERQLCEMEACRLR------VQELEAELLELQQMKQAKT 262
+ + +++ L+ V L+ EL+++Q + T
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Score = 33.5 bits (75), Expect = 0.42
Identities = 58/272 (21%), Positives = 108/272 (39%), Gaps = 35/272 (12%)
Query: 26 QDLHLAAELGKTLLERNKELEGSL---QQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAK 82
Q+L L ++N+ L +L +Q Y+ EE+ E K + H +
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC- 346
Query: 83 VYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQL 142
+QL E + HR+ +E + L E + ++ + + L+A+ +QL
Sbjct: 347 --QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE------FKQL 398
Query: 143 RVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLE----LGPR--PLEQENERLQ 196
+ RE++E+ H E+ +LHS LE LG L+++ +
Sbjct: 399 QQQREEKEQ----HGLQLQSEI---------NQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 197 TLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELE----AELL 252
+ QV+ + + R E + + +EL+ QL + + Q L+ A+L
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 253 ELQQMKQAKTYLLGPDDHLAEALLAPLTQAPE 284
E Q + +G D + L A L ++ E
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 49.7 bits (117), Expect = 6e-06
Identities = 92/434 (21%), Positives = 163/434 (37%), Gaps = 21/434 (4%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKV 83
L+Q E GK L +R ++L G + + E++ L+K+ + L+ E+ +
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 84 YEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLE--Q 141
E L+ A L N L L+ +AQ + E E L V E + E L GLE Q
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQ---KEEQQEELHLAVRERERLQEMLMGLEAKQ 535
Query: 142 LRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGA 201
L E R + + EL + + L + E L L+T V
Sbjct: 536 SESLSELITLREALESSHLEGELLRQEQTEVTAAL--ARAEQSIAELSSSENTLKTEVAD 593
Query: 202 LRSQVSQERQRKERAEREYTAVLQEYSELERQ---LC-EMEACRLRVQELEAELLELQQM 257
LR+ + E + + Q+ +LE + +C MEA L+ +L E ++
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR 653
Query: 258 KQA----KTYL---LGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPG 310
++A T+L L + L A L E + + + Q ++
Sbjct: 654 REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
Query: 311 HVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEEL 370
H K + A+ K+ R L + +V +R L E + + E E
Sbjct: 714 HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV-ERDRQDLAEQLQGLSSAKELLESS 772
Query: 371 LSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEG--QGEVKAGEKSLSQHVEAVDKR 428
L + +Q + + Q I + +++ GE + E+ Q +A ++
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
Query: 429 LEQSQPEYKALFKE 442
L Q++ E K ++
Sbjct: 833 LAQAEQEGKTALEQ 846
Score = 48.5 bits (114), Expect = 1e-05
Identities = 102/489 (20%), Positives = 194/489 (39%), Gaps = 91/489 (18%)
Query: 38 LLERNKELEGSLQQMY--------------------STNEEQVQEI----EYLTKQLD-- 71
L ER++EL+ Q++ + EQ++E+ E+LT+ L+
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 72 ------------TLRHVNEQHAKVYEQ------LDLTARDLELTNHRLVLESKAAQQKIH 113
L + K+ E+ L L R ELT R +++ +A + K
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 114 GLTE--TIERLQAQVEELQAQVE-QLRGLEQLRVLREKRERR-RTIHTFPCLKELCTSPR 169
+ ++E ++ + + + +VE Q + +L+ L+++ E++ + +H L S R
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 170 CKDAFRLH-----------------SSSLELGPRPLEQENERLQTLVGALRSQVSQERQR 212
++ L S L+ R L Q ++ L+ L + QE +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836
Query: 213 KERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLG----PD 268
KE+A+ A+ Q + L+ + E++ + + + LE EL + QA +LG
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 269 DHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAK 328
+ALLA Q A+ Q + QD A V+++ D L A+ A+
Sbjct: 1897 REQEKALLALQQQC--AEQAQEHEVETRALQDSWLQAQA----VLKE--RDQELEALRAE 1948
Query: 329 DPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEEL-----LSKCRQHGAGVRH 383
+SRH + R R ++ + + + AL K + L LS+ +
Sbjct: 1949 SQSSRH------QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ 2002
Query: 384 AGVQTSRPISRD-SSWRDLRGGEEGQGEVKAGE--KSLSQHVEAVDKRLEQSQPEYKALF 440
A + + SR ++ GE +++ E + L Q + D+ L Q + L
Sbjct: 2003 ASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Query: 441 KEIFSRIQK 449
K + R+Q+
Sbjct: 2063 KSLAQRVQE 2071
Score = 45.8 bits (107), Expect = 8e-05
Identities = 65/278 (23%), Positives = 124/278 (44%), Gaps = 55/278 (19%)
Query: 13 EEEESWYDQQD-LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEI--EYLTKQ 69
EE+ W +Q+ LE +L E +L R + E LQ+M + E ++ + E LT Q
Sbjct: 1299 EEKSKWEGKQNSLESELMELHETMASLQSRLRRAE--LQRMEAQGERELLQAAKENLTAQ 1356
Query: 70 LDTLR------HVNEQHAKVYEQLDLTARD-LELTNHRL-----------------VLES 105
++ L+ A + E+ TAR L+L N + V +
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 106 KAAQQKIHGLTETIERLQAQVEELQAQVEQLR--------GLEQLRVLREKRERRRTIHT 157
KA Q+ + LT+T+ + +VE L+ Q+++L LE L + +KR + +
Sbjct: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
Query: 158 FPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAE 217
+++ +C+ S LE P +++ ++L Q Q R+ ++ E
Sbjct: 1477 ----EQIQELEKCR-------SVLEHLPMAVQEREQKLTV-------QREQIRELEKDRE 1518
Query: 218 REYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQ 255
+ + + ELE++ +E+ R +VQ+L+ +L+ L+
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Score = 45.4 bits (106), Expect = 1e-04
Identities = 72/283 (25%), Positives = 122/283 (43%), Gaps = 40/283 (14%)
Query: 9 DFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKEL-EGSLQQMYSTNE-EQVQEIEYL 66
+ E ++ ++ + L A + GKT LE+ K E + Q+ E E+ + L
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873
Query: 67 TKQLDTL-RHVNEQHAKVYEQ-LDLTARDLELTNHRLVLESKAAQQKIH------GLTET 118
K L++L R E ++ EQ ++ A + R ES Q ++ L ET
Sbjct: 874 AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933
Query: 119 IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHS 178
+ + Q ++ + Q+E+LR +++ L+E+ E + T L+E K+A R H
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKEQ-ETTGILQTQ--LQE--AQRELKEAARQHR 988
Query: 179 ---SSLELGPRPLEQENERLQTLVGALRSQ----------VSQERQRKERAEREYTAVLQ 225
++L+ L Q+ LQ V L+SQ V QE Q K R +EY + +
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048
Query: 226 EYS------------ELERQLCEMEACRLRVQELEAELLELQQ 256
E + +R L EA +R QEL A ++Q+
Sbjct: 1049 ELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091
Score = 44.7 bits (104), Expect = 2e-04
Identities = 62/278 (22%), Positives = 110/278 (39%), Gaps = 26/278 (9%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYL 66
++ S E E +++L Q L + + L N EL+ EEQ +E+
Sbjct: 458 VDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517
Query: 67 TKQLDTLRH-VNEQHAKVYEQLD--LTARDLELTNHRLVLESKAAQQKIHGLTETIERLQ 123
++ + L+ + AK E L +T R+ ++H LE + +Q+ +T + R +
Sbjct: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSH---LEGELLRQEQTEVTAALARAE 574
Query: 124 AQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLEL 183
+ EL + L+ E + R L E A L L
Sbjct: 575 QSIAELSSSENTLK--------TEVADLRAAAVKLSALNE---------ALALDKVGLNQ 617
Query: 184 GPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLR 243
LE+EN+ + + + A + + AE+ A+ ++ + LE QL + E
Sbjct: 618 QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG-- 675
Query: 244 VQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQ 281
EL+A+L ++Q+ K+ L H EA L Q
Sbjct: 676 -AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712
Score = 43.9 bits (102), Expect = 3e-04
Identities = 101/458 (22%), Positives = 169/458 (36%), Gaps = 63/458 (13%)
Query: 38 LLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELT 97
L ++E E +L + EQ QE E T+ L Q + + Q L RD EL
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRAL--------QDSWLQAQAVLKERDQEL- 1942
Query: 98 NHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIH- 156
L ES++++ + E LQ + + A L+G EQ L E+ E R++
Sbjct: 1943 -EALRAESQSSRHQEEAARARAEALQEALGKAHAA---LQGKEQH--LLEQAELSRSLEA 1996
Query: 157 ---TFPCLKELCT--SPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQ 211
T + C S + ++A R+ ++ +++ ++LQ + ++ +++
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 212 R-----KERAEREYTAVLQEYSEL--ERQLCEMEACRLRVQEL-------EAELLELQQM 257
R K A+R ++QE L ER+ E+ V+EL E E+LEL++
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116
Query: 258 KQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSC 317
+Q P H + Q+ + D +P +L + R+
Sbjct: 2117 QQRNNLEALPHSHKTSPM---EEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKA 2173
Query: 318 SDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQH 377
D AL+ K S SV +R R DE LE L K R H
Sbjct: 2174 QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDE-----LELTRRALEKERLH 2228
Query: 378 GAGVR---------HAGVQTSRPISRDS----------SWRD-LRGGEEGQGEVKAGEKS 417
G GVQ ++ SWR L ++ ++
Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR 2288
Query: 418 LSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADIN 455
L +H + LEQ + E + L +E Q +I+
Sbjct: 2289 LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEIS 2326
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/256 (26%), Positives = 110/256 (42%), Gaps = 25/256 (9%)
Query: 24 LEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQL-----DTLRHVNE 78
L QDL + L ++ ++LE L + + E++ L +QL + + +
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 79 QHAKVYEQLDL--TARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQL 136
Q++ E ++L T L+ R L+ AQ + L E L AQVE LQA V +
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA 1367
Query: 137 RGLEQLRVLREKRERRRTIHTFPCLK-ELCTSPRCKDAFRLHSSSLELGPRPLEQENERL 195
R + E E RT + LK E S R + L++ QEN L
Sbjct: 1368 RAQASAAGILE--EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL 1425
Query: 196 --QTL------VGALRSQVSQ-ERQRK-ERAEREYTAV-----LQEYSELERQLCEMEAC 240
QTL V LR Q+ + E+QR+ ++A E ++ QE + Q+ E+E C
Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485
Query: 241 RLRVQELEAELLELQQ 256
R ++ L + E +Q
Sbjct: 1486 RSVLEHLPMAVQEREQ 1501
Score = 41.6 bits (96), Expect = 0.002
Identities = 104/479 (21%), Positives = 187/479 (39%), Gaps = 75/479 (15%)
Query: 33 ELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTAR 92
EL K ER++EL Q E + L+ L + NE + K+ + L T
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
Query: 93 DLELTNHRLVLE-----SKAAQQKIHGLTETIERL-QAQVEE------------------ 128
LE TNH ++E S+ AQ++ L + I+ + Q VEE
Sbjct: 315 ILE-TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
Query: 129 -LQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRP 187
+ +Q + + L ++R RRR L++ C++A L +
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRR--QAVQDLRQQLAG--CQEAVNLLQQQHDQWEEE 429
Query: 188 LEQENERLQTLVG---ALRSQVSQERQRKERAEREYTAVLQEYSELERQL--CEMEACRL 242
+ +RLQ L G L Q + + +E + + EL +QL E EA RL
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRL 489
Query: 243 RVQELEAEL-----------------LELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEA 285
R +E +L L +++ ++ + L+G + +E+ L+ L EA
Sbjct: 490 RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES-LSELITLREA 548
Query: 286 DDPQPGRGDDLGAQ--DGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHAN 343
+ G+ L + + ++ A + + S S+ L VA A+ + A
Sbjct: 549 LESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL 608
Query: 344 SVRKRGMSILREVDEQYHALLEKYEELLSKC-RQHGAGVRHAGVQTSRPIS---RDSSWR 399
++ K G++ LL+ EE S C R A +Q + R++ W
Sbjct: 609 ALDKVGLN---------QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 400 -------DLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTK 451
L+ EE E++A + + + E + K+L +S+ + +A ++ Q+ K
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Score = 41.6 bits (96), Expect = 0.002
Identities = 71/278 (25%), Positives = 119/278 (42%), Gaps = 46/278 (16%)
Query: 21 QQDLEQDLH-LAAELGKTLL---ERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHV 76
+ LEQ L L ++G+T L +R +E+ QQ+ E+ + + L QLD
Sbjct: 1752 KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE---- 1807
Query: 77 NEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQL 136
Q L RD EL L E + AQ + + E + LQ +E+ +++
Sbjct: 1808 --------AQRALAQRDQEL--EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Query: 137 RGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQ 196
G L++ +E+ R + +EL R R+ + LG L E+ +
Sbjct: 1858 HG-----ELQDHKEQARRLE-----EELAVEGR-----RVQALEEVLG--DLRAESREQE 1900
Query: 197 TLVGALRSQVSQERQRKERAER-------EYTAVLQEY-SELERQLCEMEACRLRVQELE 248
+ AL+ Q +++ Q E R + AVL+E ELE E ++ R + +
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 249 AELLELQQ-MKQAKTYLLGPDDHLAEALLAPLTQAPEA 285
A LQ+ + +A L G + HL E A L+++ EA
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQ--AELSRSLEA 1996
Score = 41.2 bits (95), Expect = 0.002
Identities = 91/444 (20%), Positives = 171/444 (38%), Gaps = 62/444 (13%)
Query: 38 LLERNKELEGSLQQMYSTNEEQVQEI-EYLTKQLDTLR----HVN--EQHAKVYEQLDLT 90
L+E L + Q+ + ++ +++I + + ++ D + H N E + ++ Q D
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ 382
Query: 91 ARDLELTNHRLVLESKAA-----QQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVL 145
D LT R VL + +Q++ G E + LQ Q ++ + + + LR ++L+ L
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR--QRLQKL 440
Query: 146 REKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQ 205
+R+ T E+ + + ++ + L LEQE RL+ + L+ Q
Sbjct: 441 TGERDTLAG-QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499
Query: 206 VSQERQRKERAEREYTAVLQEYSELERQLCEMEACR-------------LRVQELEAELL 252
+ +KE + E ++E L+ L +EA + L LE ELL
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 253 ELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHV 312
Q+ + L + +AE + T E D + V A +
Sbjct: 560 R-QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA---------AVKLSALNEALA 609
Query: 313 VRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSI-LREVDEQYHALLEKYEEL- 370
+ K LN + + + + A + + + L E +++ AL EK L
Sbjct: 610 LDK----VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 371 --LSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKR 428
L K + GA ++ DLR +E + E++ EA +
Sbjct: 666 AQLQKAEEAGAELQ----------------ADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 429 LEQSQPEYKALFKEIFSRIQKTKA 452
LEQ E K + + +Q+ +A
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEA 733
Score = 40.4 bits (93), Expect = 0.003
Identities = 89/466 (19%), Positives = 180/466 (38%), Gaps = 53/466 (11%)
Query: 40 ERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH 99
E+ +ELE + + E Q+ E+E + +++ R + K L+ A +LE +H
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHH 1567
Query: 100 RL--------VLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQ-----LRVLR 146
++ LE + Q++ LT L+ + +ELQAQ Q+ LE R L+
Sbjct: 1568 KMECQQKLIKELEGQRETQRV-ALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 147 EK----RERRRTIHTFPCLKELCTS--PRCKDAFRLHSSSLEL-------GPRPLEQENE 193
E+ + +R I KE T R L +++ + LE++ E
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 194 RLQTLVGALRSQVSQERQ-RKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELL 252
+++ + +++ +RQ +ERAE + LE + V+ + +
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 253 ELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHV 312
ELQ++K D L + L + E R ++ A G +
Sbjct: 1747 ELQELK----------DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
Query: 313 VRKSCS---DTALNAIVAKDPASRHAGNLTLHANS----VRKRGMSILREVDEQYHALLE 365
+S D A A+ +D A V+++ ++ +++ + L E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 366 KYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEV------KAGEKSLS 419
++ EL Q V+ R + + DLR Q + + E++
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 420 QHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK 465
VE + L+ S + +A+ KE ++ +A+ +++ + +++
Sbjct: 1917 HEVET--RALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Score = 37.4 bits (85), Expect = 0.029
Identities = 35/132 (26%), Positives = 60/132 (45%), Gaps = 15/132 (11%)
Query: 8 EDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLT 67
+D +A +EES QD + DL E K+ L + + ++Q + QE +
Sbjct: 989 DDLAALQEESSSLLQD-KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 68 KQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAA--QQKIHGLTETIERLQAQ 125
K+L+ E+ LT +E LVL+ + QQ++ L + ++ Q +
Sbjct: 1048 KELER------------EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
Query: 126 VEELQAQVEQLR 137
+EL AQ+E LR
Sbjct: 1096 QKELSAQMELLR 1107
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 49.7 bits (117), Expect = 6e-06
Identities = 62/286 (21%), Positives = 123/286 (43%), Gaps = 50/286 (17%)
Query: 11 SAEEEESWYDQQDLEQDLHLAAELGK--TLLERNKELEGSLQQMYSTNEEQVQEIEYLTK 68
S E+S Y Q +++ L L + TL E N+++E Q+M EE VQE+E +T
Sbjct: 196 SRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTD 255
Query: 69 QLDTLRHVNEQHAKVYEQLD---------------------------LTARDLELTNHRL 101
+ + ++ + Q V +QL + A + ++ +L
Sbjct: 256 EYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKL 315
Query: 102 VLESK-----AAQQKIHGLTETIERLQAQVEELQAQVEQLRGLE----QLRVLREKRERR 152
+L SK QQ +H L E ++ Q ++ Q +G++ Q+++L E+ E+
Sbjct: 316 ILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQ-QGIQERDSQIKMLTEQVEQ- 373
Query: 153 RTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQR 212
+T K C K+ + + + L +Q + ++Q+ + L+ + + +
Sbjct: 374 ---YTKEMEKNTCIIEDLKNELQRNKGASTLS----QQTHMKIQSTLDILKEKTKEAERT 426
Query: 213 KERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMK 258
E AE + +E E ++L + E+ V LE ++E++ K
Sbjct: 427 AELAEADAREKDKELVEALKRLKDYES---GVYGLEDAVVEIKNCK 469
Score = 43.5 bits (101), Expect = 4e-04
Identities = 52/262 (19%), Positives = 106/262 (40%), Gaps = 20/262 (7%)
Query: 13 EEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNE--EQVQEIEYLTKQL 70
E E++ +Q E L + LE ++ G + NE + +++E ++L
Sbjct: 72 EVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDREL 131
Query: 71 DTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ 130
+ + E+ KV EQL L + E N +L E+K ++K L + I Q Q++ +
Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQK 191
Query: 131 AQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ 190
+ RG + + ++ L E+ T + + + + Q
Sbjct: 192 ETLLSRRGEDS---DYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQ 248
Query: 191 ENERLQTLVGALRSQVSQERQRKERAERE---YTAVLQEYSELERQLCE----------- 236
E E++ +++ V Q ++ ++E Y +QE ++L + E
Sbjct: 249 EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNA 308
Query: 237 -MEACRLRVQELEAELLELQQM 257
+E +L + + E++E QQM
Sbjct: 309 KVEEWKLILSSKDDEIIEYQQM 330
Score = 37.0 bits (84), Expect = 0.038
Identities = 46/210 (21%), Positives = 95/210 (45%), Gaps = 17/210 (8%)
Query: 60 VQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRL-VLESKAAQQKIHGLTET 118
+Q+ L ++ L H+ ++ + EQ++ ++LE+T +L +E Q+ G +
Sbjct: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESS 1039
Query: 119 IERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDA--FRL 176
+++ + + + + + + ++E ER+R H + L TS + + F L
Sbjct: 1040 MDKAKKSI--TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL 1097
Query: 177 HSSSLELGPRPLEQENERLQTLVGALRSQVSQ-----ERQR---KERAEREY---TAVLQ 225
+ EL L+ + Q L L VS+ +RQR E+ E E + L+
Sbjct: 1098 ETKFAELTKINLDAQKVE-QMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR 1156
Query: 226 EYSELERQLCEMEACRLRVQELEAELLELQ 255
E S++ R+ E+ + + ++ E E L +Q
Sbjct: 1157 EISDIARRQVEILNAQQQSRDKEVESLRMQ 1186
Score = 32.7 bits (73), Expect = 0.72
Identities = 49/239 (20%), Positives = 96/239 (40%), Gaps = 30/239 (12%)
Query: 23 DLEQDLHLAAELGKT-LLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
+LE+ L E K LL E+ + + E + +I L K +D ++E
Sbjct: 905 ELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELEL 964
Query: 82 --KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL 139
K Y +L RD+ ++ LV T +E L+ + L+ QVE +
Sbjct: 965 ANKQYNELTAKYRDILQKDNMLVQR-----------TSNLEHLECENISLKEQVESIN-- 1011
Query: 140 EQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQEN-ERLQTL 198
++L + +EK +HT E T + SS++ + + + +
Sbjct: 1012 KELEITKEK------LHTIEQAWEQETKLG-------NESSMDKAKKSITNSDIVSISKK 1058
Query: 199 VGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQM 257
+ L + ERQR E ++ Y + ++E + E+E + ++ + +++QM
Sbjct: 1059 ITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQM 1117
Score = 31.2 bits (69), Expect = 2.1
Identities = 31/121 (25%), Positives = 68/121 (56%), Gaps = 13/121 (10%)
Query: 34 LGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDT-LRHVNEQHAKVYEQLDLTAR 92
L + L+E+ ++LE S + + + + +++E+ KQL+ ++ + + ++ + D+
Sbjct: 612 LSRELIEKERDLERS-RTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGG 670
Query: 93 DLEL---TNHRLV--LESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLRE 147
+ L + RLV +ESK A+ G+ + L+AQV++L + E+LR ++LR R+
Sbjct: 671 ETSLIIPSLERLVNAIESKNAE----GIFDASLHLKAQVDQLTGRNEELR--QELRESRK 724
Query: 148 K 148
+
Sbjct: 725 E 725
Score = 30.8 bits (68), Expect = 2.7
Identities = 47/206 (22%), Positives = 90/206 (43%), Gaps = 37/206 (17%)
Query: 40 ERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHV----NEQHAKVYEQLDLTARDL- 94
E K+ + ++ + + +E+ E+ LTKQL+TL+ + +++ + +L T +
Sbjct: 1913 EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVD 1972
Query: 95 ---------------ELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL 139
EL L LE+ + H + + R + VE+L Q L+
Sbjct: 1973 QVLGIRALESEKELEELKKRNLDLENDILYMRAH---QALPR-DSVVEDLHLQNRYLQ-- 2026
Query: 140 EQLRVLREKRERRRTIHTFPCLKELCTSPRC-------KDAFRLHSSSLELGPRPLEQEN 192
E+L L +++ + ++ P + + + C K+ +L S ++EL LEQ N
Sbjct: 2027 EKLHAL--EKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL-KFQLEQAN 2083
Query: 193 ERLQTLVGALRSQVSQ-ERQRKERAE 217
+ L L +R E +KE+AE
Sbjct: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAE 2109
Score = 30.4 bits (67), Expect = 3.6
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 9/126 (7%)
Query: 36 KTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLE 95
KT +E E L++ T++ + LT L+ L + ++ K Y ++ +++
Sbjct: 1788 KTQVEDLNENLLKLKEALKTSKNRENS---LTDNLNDLNNELQKKQKAYNKILREKEEID 1844
Query: 96 LTNHRLVLESKAAQQKIHG--LTET----IERLQAQVEELQAQVEQLRGLEQLRVLREKR 149
N L + K + G LT+ IE LQ +V++L+ Q+E L+ ++EK
Sbjct: 1845 QENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKN 1904
Query: 150 ERRRTI 155
+ I
Sbjct: 1905 AKEELI 1910
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 49.7 bits (117), Expect = 6e-06
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 47/292 (16%)
Query: 15 EESWYDQQDLEQDL--HLAAELGK------TLLERNK-ELEGS--------------LQQ 51
E+S + ++ +DL HL AE K ++E++K ELE L+Q
Sbjct: 577 EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ 636
Query: 52 MYSTNEEQV-----QEIEYLTKQLDTL--RHVNEQHAKVYEQLDLTARDLELTNHRLVLE 104
Y T E++ QE E L K + + H+ E + K E+LD+ +LE + L
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 105 SKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTI-HTFPCLK- 162
KA + L+ ++ +EL+A++++ + Q +V +E +I T LK
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 163 -----ELCTSPRCK--DAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKER 215
EL R K + H +LE + E E ++ + +S S ++ +
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 216 AEREYTAVLQEYSELE-------RQLCEMEACRLRV-QELEAELLELQQMKQ 259
E + + Q+ +LE +Q+ E+EA + V EL+A +++Q + Q
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQ 868
Score = 38.1 bits (87), Expect = 0.017
Identities = 59/268 (22%), Positives = 103/268 (38%), Gaps = 62/268 (23%)
Query: 39 LERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAK----VYEQLDLTARDL 94
LE + + Q M +E+++E + L +HV ++ K + L+ D+
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1838
Query: 95 ELTNHRLVLESKAAQQKIHGLTETIERLQ----AQVEELQAQVEQLRGLEQL-------R 143
+ T L + +QKI L + R + ++EEL ++ E+L+ L+Q+
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 144 VLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERL-------- 195
+L E E + H P+ + LE E+E ++L
Sbjct: 1899 LLEENTEEKSKSHL--------VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 196 ----------QTLVGALRSQVSQERQRKERAERE-----------------YTAVLQEYS 228
Q + L+ + QER+ K + E+E T + Q+
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ 2010
Query: 229 ELERQLCEMEACRLRVQELEAELLELQQ 256
ELE + E + QE+EAELLE Q
Sbjct: 2011 ELEMTIKETIN---KAQEVEAELLESHQ 2035
Score = 36.6 bits (83), Expect = 0.050
Identities = 70/315 (22%), Positives = 137/315 (43%), Gaps = 57/315 (18%)
Query: 1 MRRAAGMEDFSAEEEESWYDQ--QDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEE 58
+++ G + +A E+ES Q ++L ++++ + + L E+ E+ +Q+ N +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 59 QVQEIEYLTKQ--LDTLR-HVNEQHAKVYEQL-DLTARDLELTNHRL-VLES-------- 105
I K+ + +LR +E+ ++ +Q+ DL+ + L+ ++ LE
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 106 ----KAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCL 161
K AQ + T++ LQ Q+E L+++ E EQ+ +L+E+ +++ F CL
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLE-LKSK-EAYEKDEQINLLKEELDQQNK--RFDCL 1498
Query: 162 KELCTSPRCKDAFRLHSSSLELGPRP----------------LEQENERLQT-------- 197
K + K + + EL + +E NE L+
Sbjct: 1499 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 198 ---LVGALR--SQVSQERQR--KERAEREYTAVLQEYS---ELERQLCEMEACRLRVQEL 247
LV L+ ++ +E+ KE E+ T Q YS ELE + E+E L V+
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 248 EAELLELQQMKQAKT 262
E EL L+ ++++
Sbjct: 1619 EEELKALEDRLESES 1633
Score = 36.6 bits (83), Expect = 0.050
Identities = 51/247 (20%), Positives = 101/247 (40%), Gaps = 20/247 (8%)
Query: 20 DQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQ 79
+ ++L Q L ELG+ R KE E + + + E+E K+L+ HVN
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE---HVNLS 1614
Query: 80 HAKVYEQLDLTARDLELTNHRLVLESK-AAQQKIHGLTETIERLQAQVEELQAQVEQLRG 138
E+L LE + + E K A+QKI + ++L +Q+EE + Q ++
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK---KQLLSQMEEKEEQYKKGTE 1671
Query: 139 LEQLRVLREKRERRRTIHTF--------PCLKELCTSPRCKDAFRLHSSSLELGPRPLEQ 190
+ + +ER R +H E PR ++ E + Q
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 191 ENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAE 250
+ + + L+ ++++ + +R +E + + E+ C+ + ++++ EA+
Sbjct: 1732 KT--YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR---CQYQERLIKLEHAEAK 1786
Query: 251 LLELQQM 257
E Q M
Sbjct: 1787 QHEDQSM 1793
Score = 35.4 bits (80), Expect = 0.11
Identities = 33/142 (23%), Positives = 71/142 (50%), Gaps = 17/142 (11%)
Query: 115 LTETIERLQAQVEELQAQVEQLRGL---EQLRVLREKRERRRTIHTFPCLKELCTSPRCK 171
LT E LQ Q++E ++E+++ L E+ +++ + R+ + I K + +
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA---- 367
Query: 172 DAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELE 231
+ R +LE+ E+E +L++ + + +Q + R++KE++ER + ELE
Sbjct: 368 ETKRQMHETLEMK----EEEIAQLRSRIKQMTTQGEELREQKEKSER------AAFEELE 417
Query: 232 RQLCEMEACRLRVQELEAELLE 253
+ L + ++L+AE+ E
Sbjct: 418 KALSTAQKTEEARRKLKAEMDE 439
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/261 (22%), Positives = 119/261 (45%), Gaps = 42/261 (16%)
Query: 22 QDLEQ--DLHLAAEL--------GKTLLERNKELEGSL-----QQMYSTNEEQVQEIEYL 66
Q+LE+ DLH+A + K L+E+ ++ +G + +QM+ T E + +EI L
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 67 TKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQV 126
++ + E+ + E+ + A + E + A E +L+A++
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFE----------ELEKALSTAQKTEEARRKLKAEM 437
Query: 127 EELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPR 186
+E +E+ E++ + +E ++ + + + + + +LH L R
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVD---VMKKSSEEQIAKLQKLHEKELA---R 491
Query: 187 PLEQENERLQTLVGALRSQVSQERQRK--ERAEREYTAVLQEYSELER-QLCEMEACRLR 243
++ ++LQT R + QE+ + E+++ EY + QE + E L E+E +
Sbjct: 492 KEQELTKKLQT-----REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
Query: 244 V-QELEAELLELQQMKQAKTY 263
+ E E +L +LQQ +A+TY
Sbjct: 547 ILTESENKLRDLQQ--EAETY 565
Score = 35.4 bits (80), Expect = 0.11
Identities = 52/256 (20%), Positives = 110/256 (42%), Gaps = 20/256 (7%)
Query: 5 AGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIE 64
A +E+ A+ + S + Q L + E+ K E L Q+ + E
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 65 YLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQA 124
LTKQ+ V Q V +LD ++ +L ++ +QK+ LT+ E
Sbjct: 837 LLTKQV---AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Query: 125 QVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELG 184
+ Q Q +Q+ ++ +L+ + +++ I ++L +D+ + + E
Sbjct: 894 DGNKEQEQTKQILVEKENMILQMREGQKKEIEIL--TQKLSAK---EDSIHILNEEYETK 948
Query: 185 PRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRV 244
+ E++ E+++ +++ QE +K+ ++E A L++ ELE E+ +
Sbjct: 949 FKNQEKKMEKVKQ-----KAKEMQETLKKKLLDQE--AKLKK--ELENTALELSQ---KE 996
Query: 245 QELEAELLELQQMKQA 260
++ A++LE+ Q A
Sbjct: 997 KQFNAKMLEMAQANSA 1012
Score = 32.0 bits (71), Expect = 1.2
Identities = 33/140 (23%), Positives = 67/140 (47%), Gaps = 24/140 (17%)
Query: 14 EEESWYDQQDLEQDLH-----LAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTK 68
EE+ +Q+DLE + L E L ++ +ELE ++++ + N+ Q E E L
Sbjct: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE--TINKAQEVEAELLES 2033
Query: 69 QLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEE 128
+ + ++ A+ + L TA+ E +L+++ E + A+V +
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEE-----ILDARE------------EEMTAKVRD 2076
Query: 129 LQAQVEQLRGLEQLRVLREK 148
LQ Q+E+L+ Q ++ +E+
Sbjct: 2077 LQTQLEELQKKYQQKLEQEE 2096
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 49.3 bits (116), Expect = 7e-06
Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 47/266 (17%)
Query: 11 SAEEEESWYDQQDLEQDLHLAA-------------ELGKTLLERNKELEGSLQQMYSTNE 57
S EEE +DLE+ L E K LE+ +E + +Q+ + +
Sbjct: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
Query: 58 EQVQEIEYLTKQ-LDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLT 116
+++E K+ L+ E+ A + +++ D E+ R +++ QQ++ L
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER----AESLQQEVEALK 195
Query: 117 ETIERLQAQVEELQAQVEQLRGLE------QLRVLREKRERRRTIHTFPCLKELCTSPRC 170
E ++ L +E L+A++E+ +G + QL+ L E+ R LK+ R
Sbjct: 196 ERVDELTTDLEILKAEIEE-KGSDGAASSYQLKQLEEQNAR---------LKDALV--RM 243
Query: 171 KDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSEL 230
+D L SS +QE+ +LQ L+ ++ RQ++ER + E + EL
Sbjct: 244 RD---LSSSE--------KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDEL 292
Query: 231 ERQLCEMEACRLRVQELEAELLELQQ 256
+ Q+ V+ L L L++
Sbjct: 293 KEQVDAALGAEEMVEMLTDRNLNLEE 318
Score = 32.0 bits (71), Expect = 1.2
Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 6/161 (3%)
Query: 7 MEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYL 66
M D S+ E++ Q L + + E+ + ER L+ L Q ST +E ++++
Sbjct: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER---LQEELSQAESTIDELKEQVDAA 299
Query: 67 TKQLDTLRHVNEQHAKVYE---QLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQ 123
+ + + +++ + E +L T DLE N + A++ L E ++
Sbjct: 300 LGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAG 359
Query: 124 AQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKEL 164
A+V E Q +VE + K+ R+ T H +EL
Sbjct: 360 ARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL 400
Score = 30.0 bits (66), Expect = 4.7
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 57 EEQVQEIEYLTKQL----DTLRHVNEQHAKVYEQLDLTARD----LELTNHRLVLESKAA 108
E++ I+ L K L + L N + + + ++LD A+D +E RL
Sbjct: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 871
Query: 109 QQKIHGLTETIERLQAQVEELQAQVEQLR 137
++K ET++ LQA +++L+A+ +L+
Sbjct: 872 RKKEKEFEETMDALQADIDQLEAEKAELK 900
Score = 29.6 bits (65), Expect = 6.1
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 180 SLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCE-ME 238
SL++ L + N RL L L S +R E+ + + E++ E M+
Sbjct: 824 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 883
Query: 239 ACRLRVQELEAELLELQQ 256
A + + +LEAE EL+Q
Sbjct: 884 ALQADIDQLEAEKAELKQ 901
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,481,534
Number of Sequences: 37866
Number of extensions: 838718
Number of successful extensions: 7937
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 638
Number of HSP's that attempted gapping in prelim test: 4675
Number of HSP's gapped (non-prelim): 2568
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.