Search of human proteins with 15451910

Search of human proteins with 15451910

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
         (321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]          657   0.0  
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]           657   0.0  
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]             494   e-140
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]             494   e-140
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]             494   e-140
gi|209870073 caspase 5 isoform c [Homo sapiens]                       477   e-135
gi|209870075 caspase 5 isoform d [Homo sapiens]                       368   e-102
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]          337   6e-93
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]          337   6e-93
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]            337   6e-93
gi|15431332 caspase 1 isoform delta [Homo sapiens]                    269   3e-72
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]           95   9e-20
gi|15431334 caspase 1 isoform epsilon [Homo sapiens]                   90   3e-18
gi|14790115 caspase 3 preproprotein [Homo sapiens]                     89   7e-18
gi|14790119 caspase 3 preproprotein [Homo sapiens]                     89   7e-18
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]       74   2e-13
gi|6912286 caspase 14 precursor [Homo sapiens]                         72   9e-13
gi|15718698 caspase 7 isoform delta [Homo sapiens]                     67   3e-11
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                     67   3e-11
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]            67   3e-11
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]          64   2e-10
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]          63   3e-10
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]          63   3e-10
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]       61   1e-09
gi|14916485 caspase 6 isoform beta [Homo sapiens]                      51   1e-06
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]              51   2e-06
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]              51   2e-06
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]               51   2e-06
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]               51   2e-06
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]               51   2e-06

>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
          Length = 321

 Score =  657 bits (1694), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
           MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR
Sbjct: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60

Query: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
           LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE
Sbjct: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120

Query: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
           ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ
Sbjct: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180

Query: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
           IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV
Sbjct: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK
Sbjct: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPTIERLSMTRYFYLFPGN
Sbjct: 301 AQMPTIERLSMTRYFYLFPGN 321


>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
          Length = 377

 Score =  657 bits (1694), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
           MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR
Sbjct: 57  MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 116

Query: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
           LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE
Sbjct: 117 LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 176

Query: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
           ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ
Sbjct: 177 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 236

Query: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
           IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV
Sbjct: 237 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 296

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK
Sbjct: 297 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 356

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPTIERLSMTRYFYLFPGN
Sbjct: 357 AQMPTIERLSMTRYFYLFPGN 377


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score =  494 bits (1272), Expect = e-140
 Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)

Query: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
           + DS++ K R+A QM  QT  N+DQ   + K    +EAGPPES EST+ LKLCP EEFLR
Sbjct: 128 LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 186

Query: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
           LCK+  +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V  E
Sbjct: 187 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 246

Query: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
           +NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 247 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 306

Query: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
           IFNNRNCLSLKDKPKVIIVQACRG   GELWVRDSPASL + SSQSSENLE D+V K H 
Sbjct: 307 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 366

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 367 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 426

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPTIER ++TR FYLFPGN
Sbjct: 427 AQMPTIERATLTRDFYLFPGN 447


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score =  494 bits (1272), Expect = e-140
 Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)

Query: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
           + DS++ K R+A QM  QT  N+DQ   + K    +EAGPPES EST+ LKLCP EEFLR
Sbjct: 57  LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 115

Query: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
           LCK+  +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V  E
Sbjct: 116 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 175

Query: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
           +NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 176 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 235

Query: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
           IFNNRNCLSLKDKPKVIIVQACRG   GELWVRDSPASL + SSQSSENLE D+V K H 
Sbjct: 236 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 295

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 296 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 355

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPTIER ++TR FYLFPGN
Sbjct: 356 AQMPTIERATLTRDFYLFPGN 376


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score =  494 bits (1272), Expect = e-140
 Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)

Query: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
           + DS++ K R+A QM  QT  N+DQ   + K    +EAGPPES EST+ LKLCP EEFLR
Sbjct: 115 LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 173

Query: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
           LCK+  +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V  E
Sbjct: 174 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 233

Query: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
           +NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 234 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 293

Query: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
           IFNNRNCLSLKDKPKVIIVQACRG   GELWVRDSPASL + SSQSSENLE D+V K H 
Sbjct: 294 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 353

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 354 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 413

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPTIER ++TR FYLFPGN
Sbjct: 414 AQMPTIERATLTRDFYLFPGN 434


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score =  477 bits (1228), Expect = e-135
 Identities = 232/286 (81%), Positives = 252/286 (88%)

Query: 36  MEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPP 95
           +EAGPPES EST+ LKLCP EEFLRLCK+  +EIYPIK+R +R RLALIICNT+FDHLP 
Sbjct: 7   IEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPA 66

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNGA +DI GMK LL+GL Y+V  E+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHG
Sbjct: 67  RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHG 126

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
           ILEGICGT H +KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG   GELWVRDS
Sbjct: 127 ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDS 186

Query: 216 PASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQ 275
           PASL + SSQSSENLE D+V K H EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQ
Sbjct: 187 PASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQ 246

Query: 276 KYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           KYS CCHL E+FRKVQ+SFE P+AKAQMPTIER ++TR FYLFPGN
Sbjct: 247 KYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292


>gi|209870075 caspase 5 isoform d [Homo sapiens]
          Length = 216

 Score =  368 bits (944), Expect = e-102
 Identities = 180/216 (83%), Positives = 192/216 (88%)

Query: 106 MKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVH 165
           MK LL+GL Y+V  E+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H
Sbjct: 1   MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60

Query: 166 DEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQ 225
            +KKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG   GELWVRDSPASL + SSQ
Sbjct: 61  KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120

Query: 226 SSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEE 285
           SSENLE D+V K H EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180

Query: 286 VFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           +FRKVQ+SFE P+AKAQMPTIER ++TR FYLFPGN
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score =  337 bits (865), Expect = 6e-93
 Identities = 166/281 (59%), Positives = 208/281 (74%)

Query: 41  PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
           P S  S   +KLC  EE  R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 31  PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90

Query: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
            DITGM  LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91  VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150

Query: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
           CG  H E+ PD+L  + IF + N +NC SLKDKPKVII+QACRG + G +W +DS     
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210

Query: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
             S  ++E  E+DA+ K H+EKDFIAFCSSTP NVSWR  TMGS+FI +LI   Q+Y+  
Sbjct: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270

Query: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           C +EE+FRKV+ SFE P  +AQMPT ER+++TR FYLFPG+
Sbjct: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score =  337 bits (865), Expect = 6e-93
 Identities = 166/281 (59%), Positives = 208/281 (74%)

Query: 41  PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
           P S  S   +KLC  EE  R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 124 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 183

Query: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
            DITGM  LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 184 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 243

Query: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
           CG  H E+ PD+L  + IF + N +NC SLKDKPKVII+QACRG + G +W +DS     
Sbjct: 244 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 303

Query: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
             S  ++E  E+DA+ K H+EKDFIAFCSSTP NVSWR  TMGS+FI +LI   Q+Y+  
Sbjct: 304 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 363

Query: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           C +EE+FRKV+ SFE P  +AQMPT ER+++TR FYLFPG+
Sbjct: 364 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score =  337 bits (865), Expect = 6e-93
 Identities = 166/281 (59%), Positives = 208/281 (74%)

Query: 41  PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
           P S  S   +KLC  EE  R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 103 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 162

Query: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
            DITGM  LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 163 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 222

Query: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
           CG  H E+ PD+L  + IF + N +NC SLKDKPKVII+QACRG + G +W +DS     
Sbjct: 223 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 282

Query: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
             S  ++E  E+DA+ K H+EKDFIAFCSSTP NVSWR  TMGS+FI +LI   Q+Y+  
Sbjct: 283 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 342

Query: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           C +EE+FRKV+ SFE P  +AQMPT ER+++TR FYLFPG+
Sbjct: 343 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383


>gi|15431332 caspase 1 isoform delta [Homo sapiens]
          Length = 263

 Score =  269 bits (687), Expect = 3e-72
 Identities = 143/281 (50%), Positives = 177/281 (62%), Gaps = 48/281 (17%)

Query: 41  PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
           P S  S   +KLC  EE  R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 31  PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90

Query: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
            DITGM  LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91  VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150

Query: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
           CG  H E+ PD+L  + IF + N +NC SLKDKPKVII+QACRG                
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG---------------- 194

Query: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
                                            NVSWR  TMGS+FI +LI   Q+Y+  
Sbjct: 195 --------------------------------DNVSWRHPTMGSVFIGRLIEHMQEYACS 222

Query: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
           C +EE+FRKV+ SFE P  +AQMPT ER+++TR FYLFPG+
Sbjct: 223 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 73/254 (28%), Positives = 117/254 (46%), Gaps = 18/254 (7%)

Query: 81  LALIICNTEFD---HLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137
           LAL++ N  F     L  R+G D D + +  L + L Y V V  + TA++M+  L+ FA 
Sbjct: 201 LALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ 260

Query: 138 RPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 197
            P H+ +DS  + L+SHG+   I G   D K   +L    +FQ+F+N NC SL++KPK+ 
Sbjct: 261 LPAHRVTDSCIVALLSHGVEGAIYGV--DGK---LLQLQEVFQLFDNANCPSLQNKPKMF 315

Query: 198 IVQACRG--ANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNV 255
            +QACRG   +RG         +      +S    E+    +     D I   +      
Sbjct: 316 FIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTA 375

Query: 256 SWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERL------ 309
           + R++  GS +I  L   F + +   H+ ++  KV    +     A      R       
Sbjct: 376 AMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEY 435

Query: 310 --SMTRYFYLFPGN 321
             ++ R+ YLFPG+
Sbjct: 436 CSTLCRHLYLFPGH 449


>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
          Length = 88

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 44/81 (54%), Positives = 57/81 (70%)

Query: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
           EK  +   S    NVSWR  TMGS+FI +LI   Q+Y+  C +EE+FRKV+ SFE P  +
Sbjct: 8   EKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 67

Query: 301 AQMPTIERLSMTRYFYLFPGN 321
           AQMPT ER+++TR FYLFPG+
Sbjct: 68  AQMPTTERVTLTRCFYLFPGH 88


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)

Query: 81  LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137
           L +II N  F     +  R+G D D   ++E    L Y V  + +LT  ++   +R   +
Sbjct: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104

Query: 138 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194
           + +H    S   VL+SHG   I+ G  G V D KK        I   F    C SL  KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155

Query: 195 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 254
           K+ I+QACRG              L+      S   ++ A +K  VE DF+   S+ P  
Sbjct: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203

Query: 255 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 304
            SWR+S  GS FI  L    ++Y+    +   L  V RKV   FE      T  AK Q+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263

Query: 305 TI-ERLSMTRYFY 316
            I   L+   YFY
Sbjct: 264 CIVSMLTKELYFY 276


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)

Query: 81  LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137
           L +II N  F     +  R+G D D   ++E    L Y V  + +LT  ++   +R   +
Sbjct: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104

Query: 138 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194
           + +H    S   VL+SHG   I+ G  G V D KK        I   F    C SL  KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155

Query: 195 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 254
           K+ I+QACRG              L+      S   ++ A +K  VE DF+   S+ P  
Sbjct: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203

Query: 255 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 304
            SWR+S  GS FI  L    ++Y+    +   L  V RKV   FE      T  AK Q+P
Sbjct: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263

Query: 305 TI-ERLSMTRYFY 316
            I   L+   YFY
Sbjct: 264 CIVSMLTKELYFY 276


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 20/240 (8%)

Query: 83  LIICNTEF---DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
           LII N  F     L  R G++ D   ++     L + V+V+ +LTA+ M  AL   A + 
Sbjct: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222

Query: 140 EHKSSDSTFLVLMSHGILEG---ICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196
           +H + D   +V++SHG         G V+      V + + I  IFN  +C SL  KPK+
Sbjct: 223 DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV-EKIVNIFNGTSCPSLGGKPKL 281

Query: 197 IIVQACRGANRGELW-------VRDSPAS-LEVASSQSSENL----EEDAVYKTHVEKDF 244
             +QAC G  +   +         +SP S  E  ++   E L    + DA+       D 
Sbjct: 282 FFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDI 341

Query: 245 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 304
               S+ P  VSWRD   GS ++  L   F++++    L+ +  +V  +        QMP
Sbjct: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 67/251 (26%), Positives = 112/251 (44%), Gaps = 49/251 (19%)

Query: 80  RLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
           RLALI+C T+      R G++ D+  ++ +   L +   ++ + TA   +  L  F    
Sbjct: 18  RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72

Query: 140 EHKSS--DSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194
           + +       F+VLM+HG    L+G  G        +++  + +F+  NN+NC +L+ KP
Sbjct: 73  DSREDPVSCAFVVLMAHGREGFLKGEDG--------EMVKLENLFEALNNKNCQALRAKP 124

Query: 195 KVIIVQACRGANR--GE--------LWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 244
           KV I+QACRG  R  GE        + ++DSP ++   +         DA++     + +
Sbjct: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT---------DALHVYSTVEGY 175

Query: 245 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCC--HLEEVFRKVQQSFETPRAKAQ 302
           IA+          R    GS FI  L+  F K        L EV R++ ++      KA+
Sbjct: 176 IAY----------RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKAR 225

Query: 303 MPTIERLSMTR 313
               E  S  R
Sbjct: 226 KTNPEIQSTLR 236


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)

Query: 83  LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
           +II N  FD +     RNG D D   + +    L + V V  + +   M+  L+  A+  
Sbjct: 104 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 162

Query: 140 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 199
           +H ++     +L+SHG    I G      K  V     +   F    C +L +KPK+  +
Sbjct: 163 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 216

Query: 200 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 259
           QACRG    +         ++ A S    + + +  YK  VE DF+   S+ P   SWR 
Sbjct: 217 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 267

Query: 260 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 290
              GS F+  L +  +++     + ++  +V
Sbjct: 268 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 298


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)

Query: 83  LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
           +II N  FD +     RNG D D   + +    L + V V  + +   M+  L+  A+  
Sbjct: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129

Query: 140 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 199
           +H ++     +L+SHG    I G      K  V     +   F    C +L +KPK+  +
Sbjct: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183

Query: 200 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 259
           QACRG    +         ++ A S    + + +  YK  VE DF+   S+ P   SWR 
Sbjct: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234

Query: 260 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 290
              GS F+  L +  +++     + ++  +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 54/211 (25%), Positives = 91/211 (43%), Gaps = 19/211 (9%)

Query: 83  LIICNTEFDHLPP---RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
           +II N  FD +     RNG D D   + +    L + V V  + +   M+  L+  A+  
Sbjct: 71  IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129

Query: 140 EHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIV 199
           +H ++     +L+SHG    I G      K  V     +   F    C +L +KPK+  +
Sbjct: 130 DHTNAACFACILLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFI 183

Query: 200 QACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRD 259
           QACRG    +         ++ A S    + + +  YK  VE DF+   S+ P   SWR 
Sbjct: 184 QACRGTELDD--------GIQ-ADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRS 234

Query: 260 STMGSIFITQLITCFQKYSWCCHLEEVFRKV 290
              GS F+  L +  +++     + ++  +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 52/219 (23%), Positives = 89/219 (40%), Gaps = 21/219 (9%)

Query: 77  NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 136
           N   L +I+ N  F  L  R G   D   +  + + L ++V +  N+T  +ME  L+   
Sbjct: 281 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 340

Query: 137 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196
             P H   D     +++HG      G V+   +  + + + I   F    C  L +KPK+
Sbjct: 341 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 395

Query: 197 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 256
             +QAC+G           P+    A + + E            E DF+   ++ P  VS
Sbjct: 396 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 448

Query: 257 WRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFE 295
           +R    GS +I  L         C HL+++  ++ +  E
Sbjct: 449 FRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 12/200 (6%)

Query: 77  NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 136
           N   L +I+ N  F  L  R G   D   +  + + L ++V +  N+T  +ME  L+   
Sbjct: 281 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 340

Query: 137 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196
             P H   D     +++HG      G V+   +  + + + I   F    C  L +KPK+
Sbjct: 341 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 395

Query: 197 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 256
             +QAC+G           P+    A + + E            E DF+   ++ P  VS
Sbjct: 396 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 448

Query: 257 WRDSTMGSIFITQLITCFQK 276
           +R    GS +I  L    +K
Sbjct: 449 FRHVEEGSWYIQSLCNHLKK 468


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 12/200 (6%)

Query: 77  NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 136
           N   L +I+ N  F  L  R G   D   +  + + L ++V +  N+T  +ME  L+   
Sbjct: 238 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 297

Query: 137 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196
             P H   D     +++HG      G V+   +  + + + I   F    C  L +KPK+
Sbjct: 298 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 352

Query: 197 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 256
             +QAC+G           P+    A + + E            E DF+   ++ P  VS
Sbjct: 353 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 405

Query: 257 WRDSTMGSIFITQLITCFQK 276
           +R    GS +I  L    +K
Sbjct: 406 FRHVEEGSWYIQSLCNHLKK 425


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 83/309 (26%), Positives = 127/309 (41%), Gaps = 45/309 (14%)

Query: 30  KKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTE 89
           ++ HP   AG  E+   TDA        + R   + AE+    K  + R  +ALI  +  
Sbjct: 8   RRGHP---AGGEENMTETDAF-------YKREMFDPAEKY---KMDHRRRGIALIFNHER 54

Query: 90  FDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDS 146
           F     LP R G   D   +      L + V    +L A ++   +   +T   H  +D 
Sbjct: 55  FFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVST-VSHADADC 113

Query: 147 TFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN 206
              V +SHG  EG     +D K    +   T+  +F    C SL  KPK+ I+QACRG N
Sbjct: 114 FVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG-N 166

Query: 207 RGELWVRDSPASLEVASSQSSE------NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDS 260
           + ++ V      L+V  +Q+ +       ++  +VY      DF+   S      S R++
Sbjct: 167 QHDVPV----IPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 222

Query: 261 TMGSIFITQLITCFQKYSWCCHLEE----VFRKVQQS----FETPRA--KAQMPTIERLS 310
             GS +I  L     KY       E    V RKV Q      + P A  K Q+P    + 
Sbjct: 223 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASM- 281

Query: 311 MTRYFYLFP 319
           +T+  + FP
Sbjct: 282 LTKKLHFFP 290


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 56/195 (28%), Positives = 84/195 (43%), Gaps = 28/195 (14%)

Query: 141 HKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ 200
           H  +D    V +SHG  EG     +D K    +   T+  +F    C SL  KPK+ I+Q
Sbjct: 19  HADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72

Query: 201 ACRGANRGELWVRDSPASLEVASSQSSE------NLEEDAVYKTHVEKDFIAFCSSTPHN 254
           ACRG N+ ++ V      L+V  +Q+ +       ++  +VY      DF+   S     
Sbjct: 73  ACRG-NQHDVPV----IPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 127

Query: 255 VSWRDSTMGSIFITQLITCFQKYSWCCHLEE----VFRKVQQS----FETPRA--KAQMP 304
            S R++  GS +I  L     KY       E    V RKV Q      + P A  K Q+P
Sbjct: 128 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 187

Query: 305 TIERLSMTRYFYLFP 319
               + +T+  + FP
Sbjct: 188 CFASM-LTKKLHFFP 201


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNG   D   +    E L + +   ++ T   +   L+ +    +H + D     ++SHG
Sbjct: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 377

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
               I GT   E      +Y+   Q F    C SL  KPKV  +QAC+G N    + +  
Sbjct: 378 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 428

Query: 216 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 270
           P   +       E +L          E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 429 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 484


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNG   D   +    E L + +   ++ T   +   L+ +    +H + D     ++SHG
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 303

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
               I GT   E      +Y+   Q F    C SL  KPKV  +QAC+G N    + +  
Sbjct: 304 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 354

Query: 216 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 270
           P   +       E +L          E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 355 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNG   D   +    E L + +   ++ T   +   L+ +    +H + D     ++SHG
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 303

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
               I GT   E      +Y+   Q F    C SL  KPKV  +QAC+G N    + +  
Sbjct: 304 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 354

Query: 216 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 270
           P   +       E +L          E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 355 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNG   D   +    E L + +   ++ T   +   L+ +    +H + D     ++SHG
Sbjct: 260 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 318

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
               I GT   E      +Y+   Q F    C SL  KPKV  +QAC+G N    + +  
Sbjct: 319 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 369

Query: 216 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 270
           P   +       E +L          E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 370 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 425


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/176 (25%), Positives = 72/176 (40%), Gaps = 11/176 (6%)

Query: 96  RNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHG 155
           RNG   D   +    E L + +   ++ T   +   L+ +    +H + D     ++SHG
Sbjct: 277 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHG 335

Query: 156 ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDS 215
               I GT   E      +Y+   Q F    C SL  KPKV  +QAC+G N    + +  
Sbjct: 336 DKGIIYGTDGQEAP----IYELTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGI 386

Query: 216 PASLEVASSQSSE-NLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQL 270
           P   +       E +L          E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 387 PVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,485,776
Number of Sequences: 37866
Number of extensions: 517581
Number of successful extensions: 1393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1331
Number of HSP's gapped (non-prelim): 52
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.