Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 154354998
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354998 inositol 1,4,5-triphosphate receptor, type 1
isoform 1 [Homo sapiens]
(2710 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 5414 0.0
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 5372 0.0
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 3710 0.0
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 3280 0.0
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 166 4e-40
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 166 4e-40
gi|126032338 ryanodine receptor 3 [Homo sapiens] 164 1e-39
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 162 5e-39
gi|71061468 centromere protein E [Homo sapiens] 39 0.091
gi|41352705 kinesin family member 3C [Homo sapiens] 38 0.12
gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homol... 36 0.45
gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolo... 36 0.45
gi|7661968 epsin 4 [Homo sapiens] 35 0.77
gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens] 35 1.3
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 35 1.3
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 35 1.3
gi|29789451 cation channel, sperm associated 3 [Homo sapiens] 35 1.3
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 35 1.3
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens] 34 1.7
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens] 34 1.7
gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens] 34 1.7
gi|53729363 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|53729361 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|53729359 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens] 34 1.7
gi|157388917 FEZ family zinc finger 2 [Homo sapiens] 34 1.7
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 34 2.2
gi|62243374 MAD1-like 1 protein [Homo sapiens] 34 2.2
gi|62243369 MAD1-like 1 protein [Homo sapiens] 34 2.2
gi|62243332 MAD1-like 1 protein [Homo sapiens] 34 2.2
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 5414 bits (14045), Expect = 0.0
Identities = 2710/2710 (100%), Positives = 2710/2710 (100%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE
Sbjct: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
Query: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
Sbjct: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
Query: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
Sbjct: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
Query: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 540
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
Sbjct: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 540
Query: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
Sbjct: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
Query: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
Sbjct: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
Query: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
Sbjct: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
Query: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA
Sbjct: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
Query: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 840
SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF
Sbjct: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 840
Query: 841 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 900
VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
Sbjct: 841 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 900
Query: 901 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 960
VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE
Sbjct: 901 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 960
Query: 961 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1020
PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE
Sbjct: 961 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1020
Query: 1021 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1080
GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA
Sbjct: 1021 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1080
Query: 1081 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1140
LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP
Sbjct: 1081 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1140
Query: 1141 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1200
DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK
Sbjct: 1141 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1200
Query: 1201 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1260
QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI
Sbjct: 1201 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1260
Query: 1261 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1320
NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE
Sbjct: 1261 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1320
Query: 1321 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1380
GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE
Sbjct: 1321 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1380
Query: 1381 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1440
LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE
Sbjct: 1381 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1440
Query: 1441 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1500
IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST
Sbjct: 1441 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1500
Query: 1501 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1560
TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN
Sbjct: 1501 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1560
Query: 1561 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1620
NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ
Sbjct: 1561 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1620
Query: 1621 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1680
AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR
Sbjct: 1621 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1680
Query: 1681 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1740
EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS
Sbjct: 1681 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1740
Query: 1741 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1800
GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ
Sbjct: 1741 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1800
Query: 1801 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1860
HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK
Sbjct: 1801 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1860
Query: 1861 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1920
AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS
Sbjct: 1861 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1920
Query: 1921 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1980
AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL
Sbjct: 1921 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1980
Query: 1981 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2040
LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK
Sbjct: 1981 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2040
Query: 2041 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2100
RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE
Sbjct: 2041 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2100
Query: 2101 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2160
NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR
Sbjct: 2101 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2160
Query: 2161 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2220
LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL
Sbjct: 2161 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2220
Query: 2221 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2280
RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS
Sbjct: 2221 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2280
Query: 2281 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2340
LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT
Sbjct: 2281 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2340
Query: 2341 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2400
RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS
Sbjct: 2341 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2400
Query: 2401 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2460
IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE
Sbjct: 2401 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2460
Query: 2461 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2520
SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE
Sbjct: 2461 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2520
Query: 2521 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2580
PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK
Sbjct: 2521 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2580
Query: 2581 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2640
FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA
Sbjct: 2581 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2640
Query: 2641 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2700
MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP
Sbjct: 2641 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2700
Query: 2701 HMNVNPQQPA 2710
HMNVNPQQPA
Sbjct: 2701 HMNVNPQQPA 2710
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 5372 bits (13935), Expect = 0.0
Identities = 2695/2710 (99%), Positives = 2695/2710 (99%), Gaps = 15/2710 (0%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
SLFRFKHLATGHYLAAEVDPD QDASRSRLRNAQEKMVYSLVSVPE
Sbjct: 301 SLFRFKHLATGHYLAAEVDPD---------------QDASRSRLRNAQEKMVYSLVSVPE 345
Query: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
Sbjct: 346 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 405
Query: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
Sbjct: 406 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 465
Query: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 540
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
Sbjct: 466 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 525
Query: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
Sbjct: 526 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 585
Query: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
Sbjct: 586 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 645
Query: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
Sbjct: 646 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 705
Query: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA
Sbjct: 706 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 765
Query: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 840
SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF
Sbjct: 766 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 825
Query: 841 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 900
VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
Sbjct: 826 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 885
Query: 901 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 960
VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE
Sbjct: 886 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 945
Query: 961 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1020
PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE
Sbjct: 946 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1005
Query: 1021 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1080
GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA
Sbjct: 1006 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1065
Query: 1081 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1140
LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP
Sbjct: 1066 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1125
Query: 1141 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1200
DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK
Sbjct: 1126 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1185
Query: 1201 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1260
QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI
Sbjct: 1186 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1245
Query: 1261 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1320
NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE
Sbjct: 1246 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1305
Query: 1321 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1380
GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE
Sbjct: 1306 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1365
Query: 1381 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1440
LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE
Sbjct: 1366 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1425
Query: 1441 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1500
IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST
Sbjct: 1426 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1485
Query: 1501 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1560
TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN
Sbjct: 1486 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1545
Query: 1561 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1620
NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ
Sbjct: 1546 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1605
Query: 1621 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1680
AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR
Sbjct: 1606 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1665
Query: 1681 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1740
EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS
Sbjct: 1666 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1725
Query: 1741 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1800
GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ
Sbjct: 1726 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1785
Query: 1801 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1860
HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK
Sbjct: 1786 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1845
Query: 1861 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1920
AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS
Sbjct: 1846 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1905
Query: 1921 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1980
AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL
Sbjct: 1906 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1965
Query: 1981 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2040
LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK
Sbjct: 1966 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2025
Query: 2041 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2100
RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE
Sbjct: 2026 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2085
Query: 2101 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2160
NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR
Sbjct: 2086 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2145
Query: 2161 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2220
LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL
Sbjct: 2146 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2205
Query: 2221 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2280
RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS
Sbjct: 2206 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2265
Query: 2281 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2340
LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT
Sbjct: 2266 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2325
Query: 2341 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2400
RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS
Sbjct: 2326 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2385
Query: 2401 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2460
IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE
Sbjct: 2386 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2445
Query: 2461 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2520
SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE
Sbjct: 2446 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2505
Query: 2521 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2580
PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK
Sbjct: 2506 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2565
Query: 2581 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2640
FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA
Sbjct: 2566 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2625
Query: 2641 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2700
MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP
Sbjct: 2626 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2685
Query: 2701 HMNVNPQQPA 2710
HMNVNPQQPA
Sbjct: 2686 HMNVNPQQPA 2695
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 3710 bits (9620), Expect = 0.0
Identities = 1901/2729 (69%), Positives = 2225/2729 (81%), Gaps = 60/2729 (2%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
M++KMSSFL+IGDI SLYAEGS NGFISTLGLVDDRCVV PE GDL NPPKKFRDCLFK+
Sbjct: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQ+WKA + + T+A LL KL HAA+LE+KQNE+EN+KLLG +++Y NV
Sbjct: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLH+KSNKYLTVNKRLPALLEKNAMRV+LD AGNEGSWFYI PF+KLRS GD++V+GD
Sbjct: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVL PVNAGQPLHAS+ +L+DNPGC EVN+VNCNTSWKI LFMK+S ++D+LKGGDVV
Sbjct: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDE+ KKQH+FLRTT RQSATSATSSKALWE+EVV HDPCRGGAG WN
Sbjct: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
SLFRFKHLATG+YLAAE++PD+ + E + D S+ + R A EK++Y+LVSVP
Sbjct: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKK-RQAGEKIMYTLVSVPH 359
Query: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
GNDI+S+FELD TTL+ D LVPRNSYVRLRHLCTNTWV ST+IPID +EE+PVMLKIGT
Sbjct: 360 GNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGT 419
Query: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
KEDKEAFAIV V +EVRDLDFANDA+KVL + KLE GTITQNERR VTKLLEDL
Sbjct: 420 CQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDL 479
Query: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLE 539
++FV N+GQ+VL+VV +KPNRERQKLMREQNIL Q+F +L+APF + G+G MLRLE
Sbjct: 480 IFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLE 539
Query: 540 ELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALL 599
+LGDQR+AP++++ RLCYRVLRHSQQDYRKNQEYIAK F MQ QIGYD+LAEDTITALL
Sbjct: 540 DLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALL 599
Query: 600 HNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNP 659
HNNRKLLEKHITA EI+TFVSL+R+NREPRFLDYLSDLCVS +IPVTQELICK +L+P
Sbjct: 600 HNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSP 659
Query: 660 TNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQD 719
NADILI+TK+V + + SS L D+EEVWL+W DSNKE K++R LAQ+
Sbjct: 660 GNADILIQTKVVSMQADNPMESSI----LSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQE 715
Query: 720 AKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLR 779
AKEG K D +VL+YYRYQLNLFARMCLDRQYLAIN+IS QL VDLILRC+SDE+LP+DLR
Sbjct: 716 AKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLR 775
Query: 780 ASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS-SGASKDEIKERFAQTM 838
ASFCRLMLHMHVDRDPQE V PV+YARLW+EIP++I I +YDS + +S++++K +FA TM
Sbjct: 776 ASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTM 835
Query: 839 EFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDC 898
EFVEEYL++VV Q FPF DKEKNKLTFEVV+LARNLIYFGFY+FS+LLRLT+ LLAILD
Sbjct: 836 EFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDI 895
Query: 899 VHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNV-K 957
V +++K ++ G+NVMR+IHGVGE+MTQ+VL G PM+ P + K
Sbjct: 896 VQAPMSSYFERLSKFQDG-GNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSK 954
Query: 958 QAEP-EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGN 1016
Q P E ED+ VMDTKLKIIEILQFIL+VRLDYRIS +L I+K+EF E N ++SG+
Sbjct: 955 QGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGS 1014
Query: 1017 SSQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPL 1076
PS + D + I QAE +F GRKE P+ LDD GGRTFLRVL+HL MHDYPPL
Sbjct: 1015 PDTLLPSAI--VPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPL 1072
Query: 1077 VSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYK 1136
+SGALQLLF+HFSQR EVLQAFKQVQLLV++QDVDNYKQIK DLDQLR VEKSELWV K
Sbjct: 1073 LSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEK 1132
Query: 1137 GQGPDETMDGASGENEHKKTEE-------------GNNKPQKHESTSSYNYRVVKEILIR 1183
+ +G GE++ K EE G KPQ +S S NYR+VKEILIR
Sbjct: 1133 SSNYE---NGEIGESQVKGGEEPIEESNILSPVQDGTKKPQI-DSNKSNNYRIVKEILIR 1188
Query: 1184 LSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1243
LSKLCVQ +K R Q QRLL+NMGAH+VVL+LLQIPYEK D KM E+M LAH FLQ
Sbjct: 1189 LSKLCVQN----KKCRNQHQRLLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQ 1243
Query: 1244 NFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETH 1303
NFC GN QNQ LLHKH+NLFL PG+LEA TM+HIFMNN+ LC+EI+ERVVQHFVHCIETH
Sbjct: 1244 NFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETH 1303
Query: 1304 GRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSER 1363
GR+V+Y++FLQTIVKA+GK++KKCQDMVM EL+N GEDVL+FYNDRASF L+ MM SER
Sbjct: 1304 GRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSER 1363
Query: 1364 DRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAY 1423
DR DE+ PL YHI LVELLA CTEGKNVYTEIKCNSLLPLDDIVRVVTH+DCIPEVKIAY
Sbjct: 1364 DRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAY 1423
Query: 1424 INFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIV 1483
+NF+NHCYVDTEVEMKEIYTSNH+WKLFENFLVD+ R CN T+DRKHAD LEK VTE +
Sbjct: 1424 VNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESI 1483
Query: 1484 MSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDV 1543
M+IV+ FF+SPFSD ST+LQT QPVF+QLLQ FR+Y+C W P+QKASVESCIR L++V
Sbjct: 1484 MNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEV 1543
Query: 1544 AKSRAIAIPVDLDSQVNNLFLKSHS-IVQKTAMNWRLSARNAAR-RDSVLAASRDYRNII 1601
AK+R IAIPVDLDSQVN LF+KSHS +VQ+ AM WRLSAR+ R ++++ + DYRNII
Sbjct: 1544 AKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNII 1603
Query: 1602 ERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTK 1661
E+LQD+V++LE + P++QAE SVLVDVL+ PELLFPE +DAR +C G F+ KLI HTK
Sbjct: 1604 EKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTK 1661
Query: 1662 QLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFG 1721
+L+E+ EEKLCIK+LQTLREM+ K + E+G LR++L+NRY+ G
Sbjct: 1662 KLMEK-EEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIG--------V 1712
Query: 1722 NGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVF 1781
NG LS GG SG S G +S++++QC LDKEGAS LVID+I+N +DR+F
Sbjct: 1713 NGHLSGAYSKTAQVGGSFSGQDSDKMG-ISMSDIQCLLDKEGASELVIDVIVNTKNDRIF 1771
Query: 1782 HESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSD 1841
E I L IALLEGGNT Q+SF+ +L E KKSEKFFKV YDRMK AQ+EI++TVTVNT D
Sbjct: 1772 SEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTID 1831
Query: 1842 LGNKKKDDEVD-RDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DH 1899
LGNKK+DD+ + + R + ++ T + E ++ QL EAS+AT KA+ +RRE DP+ D
Sbjct: 1832 LGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDI 1891
Query: 1900 YQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNL 1959
G T +K+ +++ MS I IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNL
Sbjct: 1892 MCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNL 1951
Query: 1960 VCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHE 2019
VCETLQFLDCICGSTTGGLGLLGLYINEKNVAL+NQ LESLTEYCQGPCHENQ CIATHE
Sbjct: 1952 VCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHE 2011
Query: 2020 SNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPK 2079
SNGIDII ALILNDINPLGK RMDLVL+LKNNASKLLLAIMESRHDSENAERIL+NMRP+
Sbjct: 2012 SNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPR 2071
Query: 2080 ELVEVIKKAYMQG-EVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGG 2138
ELV+V+K AY QG E + D E G+DG SP++VGHNIYILAHQLARHNK LQ MLKPG
Sbjct: 2072 ELVDVMKNAYNQGLECDHGDDEGGDDG-VSPKDVGHNIYILAHQLARHNKLLQQMLKPGS 2130
Query: 2139 QVD-GDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQG 2197
D GDEAL++YA HTAQIEIVR DRTMEQIVFPVP+ICE+LT+ESK R++ TTERDEQG
Sbjct: 2131 DPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQG 2190
Query: 2198 SKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPF 2257
SK+NDFF ++EDL+NEM WQKK+R P L+W +R++S W SISFNLAV +NL VA FYPF
Sbjct: 2191 SKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF 2250
Query: 2258 KGVRG--GTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLF 2315
G G GTL P +S LLW A+ I +++ KP GIR + S +LR I+++GL PTL
Sbjct: 2251 -GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLI 2309
Query: 2316 LLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSL 2375
LLGA N+CNKI+FL+SFVGN GTFTRGYRA++LD+ FLYH+ Y+++C +GLFVHEFFYS
Sbjct: 2310 LLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSF 2369
Query: 2376 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLP 2435
LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSI+G+LF KDDF +EVDRL
Sbjct: 2370 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLK 2429
Query: 2436 NETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCI 2495
N T P TG + + + ENCS P EE E E TC+TLLMCI
Sbjct: 2430 NRT--PVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTAD-EEYEDGIERTCDTLLMCI 2486
Query: 2496 VTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFAD 2555
VTVL+ GLR+GGGVGDVLR+PSK+EPLFAARV+YDLLF+F+VIIIVLNLIFGVIIDTFAD
Sbjct: 2487 VTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFAD 2546
Query: 2556 LRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTE 2615
LRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EHNMWHYL FIVLVKVKD TE
Sbjct: 2547 LRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTE 2606
Query: 2616 YTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQ 2675
YTGPESYVA+MI E+NLDWFPRMRAMSLVS++ + EQNE+R+LQEKLESTM LV LSGQ
Sbjct: 2607 YTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQ 2666
Query: 2676 LSELKDQMTEQRKQKQRIGLLG-HPPHMN 2703
L+ELK+QMTEQRK KQR+G LG + PH+N
Sbjct: 2667 LAELKEQMTEQRKNKQRLGFLGSNTPHVN 2695
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 3280 bits (8504), Expect = 0.0
Identities = 1700/2742 (61%), Positives = 2085/2742 (76%), Gaps = 130/2742 (4%)
Query: 4 KMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPM 63
+MSSFLHIGDI SLYAEGS NGFISTLGLVDDRCVV+P GDL+NPPKKFRDCLFK+CPM
Sbjct: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
Query: 64 NRYSAQKQFWKA--AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVI 121
NRYSAQKQ+WKA K D VLL KL HAA +E+KQN+TEN+K+ G V++YG+VI
Sbjct: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
Query: 122 QLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDK 181
QLLH+KSNKYLTVNKRLPALLEKNAMRVTLD GNEGSW +IQPF+KLRS GD+VV+GDK
Sbjct: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
Query: 182 VVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVR 241
V+LNPVNAGQPLHAS+++L DN GC EVNSVNCNTSWKI LFM++ D+ +++LKGGDVVR
Sbjct: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
Query: 242 LFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNS 301
LFHAEQEKFLTCDE++ K VFLRTT RQSATSATSS ALWEVEVV HDPCRGGAG+WN
Sbjct: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
Query: 302 LFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEG 361
L+RFKHLATG+YLAAE +P ++ + + P R+ RNA EK+ Y LV+VP G
Sbjct: 303 LYRFKHLATGNYLAAEENPSYKGDASD--PKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG 360
Query: 362 NDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTS 421
NDI+S+FELDPTTL+ DS VPRNSYVRLRHLCTNTW+ STN+PID EEE+P+ L +GT
Sbjct: 361 NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC 420
Query: 422 PVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLV 481
P KEDKEAFAIV V +E+RDLDFANDAS +L S KL +G I+QN+RR V +LLEDLV
Sbjct: 421 PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV 480
Query: 482 YFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEE 540
+FV+ N+GQ+VL+++ +KPNRERQKLMREQNILKQ+F +L+APF + G+GP++RLEE
Sbjct: 481 FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE 540
Query: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
L DQ++AP++H+ RLCYRVLRHSQ+DYRKNQE+IAKQFG MQ QIGYD+LAEDTITALLH
Sbjct: 541 LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH 600
Query: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
NNRKLLEKHIT E++TFVSLVRKNREPRFLDYLSDLCVS + +IPVTQELICK VL+P
Sbjct: 601 NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK 660
Query: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
N+DILI T+L + + L EEEVWL W D N E KSVR+LAQ+A
Sbjct: 661 NSDILIRTELRPVK-----EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEA 715
Query: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
+ G D +VLSYYRYQL LFARMCLDRQYLAI+EIS QL VDLI CM+DE LP+DLRA
Sbjct: 716 RAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRA 775
Query: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSS-GASKDEIKERFAQTME 839
SFC LMLH+HVDRDPQE VTPVK+ARLW+EIP+ I I DYDS+ AS+D+ K +FA TME
Sbjct: 776 SFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTME 835
Query: 840 FVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 899
FVE+YL +VV + PF+++EKNKLTFEVV+LA NLIYFGFY+FS+LLRLT+ LL I+DCV
Sbjct: 836 FVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCV 895
Query: 900 HVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPM----AAAPEGN 955
P + + E+ G NV RSI GVG +M+ +VL + P A+A E
Sbjct: 896 Q----GPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPL 951
Query: 956 VKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSG 1015
+ E EDI+VM+TKLKI+EILQFILNVRLDYRIS LL +FK+EF E + S
Sbjct: 952 DRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPM--QDSGA 1009
Query: 1016 NSSQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPP 1075
+ + + ++ + I EQAE +FG K ++ L++DD GGR FLRVL+HLTMHDY P
Sbjct: 1010 DGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAP 1069
Query: 1076 LVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVY 1135
LVSGALQLLF+HFSQRQE + FKQVQLL+++QDV+NYK IK +LD+LR++VEKSELWV
Sbjct: 1070 LVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVD 1129
Query: 1136 K---GQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQES 1192
K G+G + A + E EEG P + SS NY++VK IL RL+K+C
Sbjct: 1130 KKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEK--SSENYQIVKGILERLNKMC---- 1183
Query: 1193 ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQN 1252
+ RK+QQRLL+NM AH V+L+LLQIPY+K D KM EI+R H+FLQ FCAGN N
Sbjct: 1184 GVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKG-DAKMMEILRYTHQFLQKFCAGNPGN 1242
Query: 1253 QALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKF 1312
QALLHKH++LFL PG+LEA TMQHIF+NN+QLCSEI+E V+QHFVH + THGR+VQY+ F
Sbjct: 1243 QALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDF 1302
Query: 1313 LQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPL 1372
L T++KAEGK++KKCQDM+M EL N+G+DV+VFYND+AS L+ MM++ RD ++++SPL
Sbjct: 1303 LHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPL 1362
Query: 1373 MYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYV 1432
MYHI LV+LLA C EGKNVYTEIKC SLLPL+D+V VVTHEDCI EVK+AY+NF+NHCYV
Sbjct: 1363 MYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYV 1422
Query: 1433 DTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFS 1492
DTEVEMKEIYTSNH+W LFENF +D+ R C+ +++ AD LEKYV +V+ + FFS
Sbjct: 1423 DTEVEMKEIYTSNHIWTLFENFTLDMARVCSK-REKRVADPTLEKYVLSVVLDTINAFFS 1481
Query: 1493 SPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIP 1552
SPFS+ ST+LQT Q + VQLLQ R+ C WL K SVE+CIR L+ VAK RAI +P
Sbjct: 1482 SPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLP 1541
Query: 1553 VDLDSQVNNLFLKSHS---IVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVS 1609
+DLD+ ++++ S Q+ A +++ + R A R + A DY+NIIE+LQDI++
Sbjct: 1542 MDLDAHISSMLSSGASCAAAAQRNASSYKATTR-AFPRVTPTANQWDYKNIIEKLQDIIT 1600
Query: 1610 ALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEE 1669
ALE+RL+PLVQAELSVLVDVLH PELLF E ++A ++CESGGF+ KLI+HTK L+ E+EE
Sbjct: 1601 ALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM-ESEE 1659
Query: 1670 KLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGG 1729
KLCIKVL+TL++M+ K YG++G LR++L+ Y N + + R + G G
Sbjct: 1660 KLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTG------ 1713
Query: 1730 PGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAI 1789
+ ++A QC LDKEGA+ LV DLI + ++++F ESI LAI
Sbjct: 1714 ---------------LDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAI 1758
Query: 1790 ALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDD 1849
LL+GGNT IQ SF + DKKSE+FFKV +DRMK AQQE K+TV VN +DLG++ +D
Sbjct: 1759 HLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED 1818
Query: 1850 EVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQAT 1909
++ +PTT+ V + S++ + RR + + Q
Sbjct: 1819 ---------REPVDPTTK--GRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSS------ 1861
Query: 1910 ADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDC 1969
EM + IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD
Sbjct: 1862 --------EMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDI 1913
Query: 1970 ICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITAL 2029
+CGSTTGGLGLLGLYINE NV L+ QTLE+LTEYCQGPCHENQ CI THESNGIDIITAL
Sbjct: 1914 MCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITAL 1973
Query: 2030 ILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAY 2089
ILNDI+PL K RMDLVL+LK+NASKLLLA+MESRHDSENAERIL ++RP+ELV+VIKKAY
Sbjct: 1974 ILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAY 2033
Query: 2090 MQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEA---- 2145
+Q E+ EN E SPR VGHNIYILA QL+RHNK+LQ +LKP ++ +EA
Sbjct: 2034 LQE----EERENSE---VSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGIS 2086
Query: 2146 ---------------------------LEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEF 2178
L +Y HT+QIEIVR DR+MEQIVFPVP IC+F
Sbjct: 2087 SMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQF 2146
Query: 2179 LTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSS 2238
LT+E+K R++ TTE+DEQGSK++DFF +S L NEM WQ+KLR+ P++YW +R M+ W S
Sbjct: 2147 LTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGS 2206
Query: 2239 ISFNLAVLMNLLVAFFYPF-KGVRGGTLE-PHWSGLLWTAMLISLAIVIALPKPHGIRAL 2296
ISFNLAV +N+++AFFYP+ +G G L+ P S L W +LI +I K + IR L
Sbjct: 2207 ISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFW--ILICFSIAALFTKRYSIRPL 2264
Query: 2297 IASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHL 2356
I + ILR I+ +G+ PTL +LGA N+ NKI+F++SFVGN GTF RGY+AMV+D+EFLYH+
Sbjct: 2265 IVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHV 2324
Query: 2357 LYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFS 2416
Y++ +GLF HE FYS+LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFS
Sbjct: 2325 GYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFS 2384
Query: 2417 IVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGE--NCSSPAPREEL 2474
IVG+LF KDDFILEVDRLPN + F D C SG+ +C S E+
Sbjct: 2385 IVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTC---SGDKMDCVSGLSVPEV 2441
Query: 2475 VPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFF 2534
+ + E C+TLLMCIVTV++HGLR+GGGVGD+LRKPSK+E LF ARV+YDLLFF
Sbjct: 2442 LEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFF 2501
Query: 2535 FMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKE 2594
F+VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK
Sbjct: 2502 FIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKL 2561
Query: 2595 EHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNE 2654
EHNMW+YL FIVLV+VK+ T+YTGPESYVA+MIK +NLDWFPRMRAMSLVS++ EGEQNE
Sbjct: 2562 EHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNE 2621
Query: 2655 LRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2696
+R LQ+KL STMKLV++L+ QL+ELK+QMTEQRK++QR+G +
Sbjct: 2622 IRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 166 bits (419), Expect = 4e-40
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4782 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4840
Query: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
++VYL+++V + FF+
Sbjct: 4841 AVVVYLYTVVAFNFFR-------------------------------------------- 4856
Query: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E RV+
Sbjct: 4857 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELYRVV 4911
Query: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4912 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4971
Query: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
E H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4972 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5019
Score = 82.4 bits (202), Expect = 5e-15
Identities = 129/585 (22%), Positives = 232/585 (39%), Gaps = 79/585 (13%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
Query: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
Query: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMV 352
G W R +H+ TG YLA E++ L + A+ R ++EK+
Sbjct: 269 SGSHLRWGQPLRVRHVTTGQYLALT-----EDQGLVVVDASKAHTKATSFCFRISKEKL- 322
Query: 353 YSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEK 412
V D+ + P ++ G+SL ++H+ + W +
Sbjct: 323 ----DVAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPD 362
Query: 413 PVMLKIGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAG 458
P L++G K +A ++ E + N K L S +G
Sbjct: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSG 422
Query: 459 KLE-----KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQ 513
K GT E V L+DL+ + + Q + + R RQ L +E+
Sbjct: 423 KPRGSGPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
Query: 514 NILKQIFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQ 571
+L + + +T E G++ ++ I L Y +L + R N
Sbjct: 481 GMLSMVLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNC 536
Query: 572 EYIAKQFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-R 626
+ ++ ++ + E L+ + L I I + +SL+ K+ R
Sbjct: 537 ALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGR 594
Query: 627 EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671
+ LD L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 595 NHKVLDVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
Score = 70.9 bits (172), Expect = 2e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 3761 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3819
Query: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 3820 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3857
Query: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
T R Q GE A + +D + RFL
Sbjct: 3858 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3882
Query: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3883 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3942
Query: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 3943 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4002
Query: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 4003 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4062
Query: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2105
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 4063 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4122
Query: 2106 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 4123 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4177
Query: 2159 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2212
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 4178 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4237
Query: 2213 EM 2214
EM
Sbjct: 4238 EM 4239
Score = 43.9 bits (102), Expect = 0.002
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 1190 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1236
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
Query: 1237 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1288
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
Query: 1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1343
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
Score = 32.0 bits (71), Expect = 8.5
Identities = 15/67 (22%), Positives = 33/67 (49%)
Query: 726 EDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRL 785
E D+ ++ + L L+ +C + + +D +L + D +LP LRA + L
Sbjct: 1654 ERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDL 1713
Query: 786 MLHMHVD 792
++ +H++
Sbjct: 1714 LISIHLE 1720
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 166 bits (419), Expect = 4e-40
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
Query: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
++VYL+++V + FF+
Sbjct: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
Query: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E RV+
Sbjct: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELYRVV 4916
Query: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4917 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4976
Query: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
E H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4977 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
Score = 82.4 bits (202), Expect = 5e-15
Identities = 129/585 (22%), Positives = 232/585 (39%), Gaps = 79/585 (13%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
Query: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
Query: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMV 352
G W R +H+ TG YLA E++ L + A+ R ++EK+
Sbjct: 269 SGSHLRWGQPLRVRHVTTGQYLALT-----EDQGLVVVDASKAHTKATSFCFRISKEKL- 322
Query: 353 YSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEK 412
V D+ + P ++ G+SL ++H+ + W +
Sbjct: 323 ----DVAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPD 362
Query: 413 PVMLKIGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAG 458
P L++G K +A ++ E + N K L S +G
Sbjct: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSG 422
Query: 459 KLE-----KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQ 513
K GT E V L+DL+ + + Q + + R RQ L +E+
Sbjct: 423 KPRGSGPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
Query: 514 NILKQIFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQ 571
+L + + +T E G++ ++ I L Y +L + R N
Sbjct: 481 GMLSMVLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNC 536
Query: 572 EYIAKQFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-R 626
+ ++ ++ + E L+ + L I I + +SL+ K+ R
Sbjct: 537 ALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGR 594
Query: 627 EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671
+ LD L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 595 NHKVLDVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
Score = 70.9 bits (172), Expect = 2e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Query: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
Query: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
T R Q GE A + +D + RFL
Sbjct: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
Query: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
Query: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
Query: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
Query: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2105
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
Query: 2106 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
Query: 2159 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2212
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
Query: 2213 EM 2214
EM
Sbjct: 4243 EM 4244
Score = 43.9 bits (102), Expect = 0.002
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 1190 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1236
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
Query: 1237 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1288
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
Query: 1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1343
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
Score = 32.0 bits (71), Expect = 8.5
Identities = 15/67 (22%), Positives = 33/67 (49%)
Query: 726 EDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRL 785
E D+ ++ + L L+ +C + + +D +L + D +LP LRA + L
Sbjct: 1654 ERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDL 1713
Query: 786 MLHMHVD 792
++ +H++
Sbjct: 1714 LISIHLE 1720
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 164 bits (414), Expect = 1e-39
Identities = 90/288 (31%), Positives = 151/288 (52%), Gaps = 50/288 (17%)
Query: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
D FLY Y + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
Query: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
++VYL+++V + FF+
Sbjct: 4678 AVVVYLYTVVAFNFFR-------------------------------------------- 4693
Query: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528
+ E + + + C+ ++ C + + G+R+GGG+GD + P+ + P R++
Sbjct: 4694 ----KFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
Query: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588
+D+ FFF VI+I+L +I G+IID F +LR ++++ E ++T CFICG+ D FD F
Sbjct: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
Query: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
Score = 99.8 bits (247), Expect = 3e-20
Identities = 127/568 (22%), Positives = 228/568 (40%), Gaps = 49/568 (8%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ + L H S YLT + +K A V L E A E W+ I P K RS G+
Sbjct: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V IGD ++L V++ + LH S V N G +V++ T W + S ++ L
Sbjct: 165 VRIGDDLILVSVSSERYLHLS----VSN-GNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
Query: 236 GGDVVRLFHAEQEKF-LTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRG 294
GG VVRLFH E + + QH R ++ + T +++LW VE ++ G
Sbjct: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
Query: 295 GAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYS 354
W FR +HL TGHYLA E++ L Q D ++ R ++E
Sbjct: 276 SNIRWGQAFRLRHLTTGHYLALT-----EDQGLILQDRAKSDTKSTAFSFRASKE----- 325
Query: 355 LVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPV 414
L + + I + ++ GDS+ ++H+ + WV P+
Sbjct: 326 LKEKLDSSHKRDIEGMGVPEIKYGDSV------CFVQHIASGLWVTYKAQDAKTSRLGPL 379
Query: 415 MLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGS-IAGKLEKGTITQNERRSV 473
K+ + + E + + + + ++G V
Sbjct: 380 KRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEV 439
Query: 474 TKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA--PFTDCG 531
+ L+DL+ + + + + + RQ L +E+ +L + + +
Sbjct: 440 LQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVA 499
Query: 532 DGPMLRLEELGDQRHAPFRHICRLCYRVL-------RHSQQDYRKNQEYIAKQFGFMQKQ 584
+ EE G ++ I L Y++L R++ + N +++ + ++
Sbjct: 500 HFAGIAREESG----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESS 555
Query: 585 IGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFLDYLSDLCVSMNK 643
G + + +L + + L I I + +SL+ K+ R + LD L LC+
Sbjct: 556 SG----ILEVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGV 610
Query: 644 SIPVTQELICKAVLNPTNADILIETKLV 671
++ Q LIC +L N +L++T+L+
Sbjct: 611 AVRANQNLICDNLLPRRN--LLLQTRLI 636
Score = 79.7 bits (195), Expect = 4e-14
Identities = 110/494 (22%), Positives = 190/494 (38%), Gaps = 140/494 (28%)
Query: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Q L + GA+ +V+ +I + + + E++ L IA+L GGN +Q L E KK
Sbjct: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
Query: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
FF+ M+ + + +N + NK A E T I E
Sbjct: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRERG 3722
Query: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
+++L+ TR F RFL
Sbjct: 3723 EKVLQNDEFTRDLF-------------------------------------------RFL 3739
Query: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
QLLCE HN D QNFLR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3740 QLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQ 3799
Query: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
+ K +A+ Q SLTEY QGPC NQ +A + +S+
Sbjct: 3800 HNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSS 3859
Query: 2022 GIDIITAL--ILNDI--------------NPLGKKRMDLVLELKNNASKLL--------- 2056
I+++ L +L D+ +GK+ +D ++E N +L
Sbjct: 3860 QIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKL 3919
Query: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2102
L ++ + + + + + + + +K Y Q E++F E EN
Sbjct: 3920 KDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDF 3979
Query: 2103 EDGAASP-RNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
D P +++G N+ +L L+ H + L+ +L P + L ++ + +IEI
Sbjct: 3980 VDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP-----AESVLNYFEPYLGRIEI 4034
Query: 2159 VRLDRTMEQIVFPV 2172
+ + +E++ F +
Sbjct: 4035 MGGAKKIERVYFEI 4048
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 162 bits (409), Expect = 5e-39
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
D FLY Y+ + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
Query: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
++VYL+++V + FF+ + E+ +P
Sbjct: 4775 AVVVYLYTVVAFNFFRKFY--------------------------------NKSEDGDTP 4802
Query: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528
+ C+ +L C + + G+R+GGG+GD + P+ +E R+I
Sbjct: 4803 ----------------DMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
Query: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
Query: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER ++FP
Sbjct: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
Score = 96.7 bits (239), Expect = 3e-19
Identities = 141/589 (23%), Positives = 238/589 (40%), Gaps = 88/589 (14%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL + +K A V L E E W+ I P K RS G+
Sbjct: 115 YGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 174
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S G V++ T W + S+ L
Sbjct: 175 VRVGDDLILVSVSSERYLHLSY-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLI 229
Query: 236 GGDVVRLFHAEQEKFLT--CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCR 293
GGDV+RL H ++ LT EH ++Q RT + + +++LW +E ++
Sbjct: 230 GGDVLRLLHGHMDECLTVPSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLR-VAWS 285
Query: 294 GGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVY 353
G W FR +H+ TG YL+ E++ L D ++ R+++EK+
Sbjct: 286 GSHIRWGQPFRLRHVTTGKYLSL-----MEDKNLLLMDKEKADVKSTAFTFRSSKEKLDV 340
Query: 354 SLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTW-----VHSTNIPIDK 408
+ +G S I + GDS+ ++H+ T W V ++ +
Sbjct: 341 GVRKEVDGMGTSEI--------KYGDSV------CYIQHVDTGLWLTYQSVDVKSVRMGS 386
Query: 409 EEEKPVM-----LKIGTSPVKEDKEAFAIVPVSPAEVRDLDFA-NDASKVLGSIAGKLEK 462
+ K +M + G S + E V +R F N + L +++ K +
Sbjct: 387 IQRKAIMHHEGHMDDGISLSRSQHEESRTARV----IRSTVFLFNRFIRGLDALSKKAKA 442
Query: 463 GTITQNERRSVTKLLEDLV-YFVTGGTNSGQDVLEVVFSKPNR-----ERQKLMREQNIL 516
T+ SV+ L+DL+ YF + + K NR RQ L +E+ ++
Sbjct: 443 STV-DLPIESVSLSLQDLIGYFHPPDEHLEHE------DKQNRLRALKNRQNLFQEEGMI 495
Query: 517 KQIFKLLQ--------APFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYR 568
+ + + A F D G + ++ I Y +L + R
Sbjct: 496 NLVLECIDRLHVYSSAAHFADVA----------GREAGESWKSILNSLYELLAALIRGNR 545
Query: 569 KNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH-----ITAAEIDTFVSLVR 623
KN + ++ ++ + A I +LH L+E I I + +SL+
Sbjct: 546 KNCAQFSGSLDWLISRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLD 602
Query: 624 KN-REPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671
K+ R + LD L LCV ++ Q LIC +L D+L++T+LV
Sbjct: 603 KHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLL--PGRDLLLQTRLV 649
Score = 72.0 bits (175), Expect = 7e-12
Identities = 107/494 (21%), Positives = 183/494 (37%), Gaps = 146/494 (29%)
Query: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Q L GA+ +V+ I + + + ++ L IA+L GGN+T+Q L E KK
Sbjct: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKE-KKD 3786
Query: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
FF+ S G + +D +A R+ E +TEE
Sbjct: 3787 VGFFQ---------------------SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEE-- 3823
Query: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
+ +K D E + + RFL
Sbjct: 3824 ----------------------------------GSGEKVLQDDEFTC------DLFRFL 3843
Query: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3844 QLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQ 3903
Query: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
K + + Q +LTEY QGPC NQ +A + +S+
Sbjct: 3904 RNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSS 3963
Query: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056
I+++ L+ N +N +GK+ +D+++E NN +L
Sbjct: 3964 QIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKL 4023
Query: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2102
L ++ + + + + + R K Y Q E EF E EN
Sbjct: 4024 KDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEF 4083
Query: 2103 -EDGAASPRNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
+ +++G N+ +L L+ H + LQ+ L+ + L ++ +IEI
Sbjct: 4084 VKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL-----AESVLNYFQPFLGRIEI 4138
Query: 2159 VRLDRTMEQIVFPV 2172
+ + +E++ F +
Sbjct: 4139 MGSAKRIERVYFEI 4152
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 38.5 bits (88), Expect = 0.091
Identities = 59/284 (20%), Positives = 124/284 (43%), Gaps = 24/284 (8%)
Query: 1100 QVQLLVTSQDVDNYKQIKQDL----DQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK 1155
Q ++ +++ DN K IK+ L DQL+ + ++ + + Q E + + + +
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE--QSLNMKEKDNE 1398
Query: 1156 TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQ---ESASVRKSRKQQQRLLRNMGAH 1212
T + ++ ++ + S R+ E+L LSK + E SV K + QRL + +
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEML-GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 1213 AVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAV 1272
+ L+ I A+ + +E +++AH C +Q + + +NL + +
Sbjct: 1458 SDQLKE-NIKEIVAKHLETEEELKVAH------CCLKEQEETINELRVNLSEKETEISTI 1510
Query: 1273 TMQHIFMNNF--QLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDM 1330
Q +N+ EI E+ Q + I V +K + KA+ ++ +
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 1331 VMAELVN----SGEDVLVFYNDRASFQTLIQMMRSERDRMDENS 1370
M EL N S E++ + ++ + + + ++ ERD++ EN+
Sbjct: 1571 -MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613
Score = 37.0 bits (84), Expect = 0.26
Identities = 50/260 (19%), Positives = 113/260 (43%), Gaps = 20/260 (7%)
Query: 1092 QEVLQAFK--QVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASG 1149
QE +Q K + QL+ +DV+ ++ +++QL+ ++ L + K + + +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 1150 EN--EHKKTEEGNNKPQKHESTSSYNYRVVKEIL--IRLSKLCVQESASV-----RKSRK 1200
EN E K + + ++ E T +KE L + L +Q+ ++ ++
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Query: 1201 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1260
+L + + + +Q +K++D ++I L + LQ N + HK I
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS--HKKI 1996
Query: 1261 N---LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIV 1317
N + ++MQ + M+NFQL +++E + + + + ++ IK +++
Sbjct: 1997 NEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE--IRIVAKERDELRRIK--ESLK 2052
Query: 1318 KAEGKFIKKCQDMVMAELVN 1337
+FI ++M+ + N
Sbjct: 2053 MERDQFIATLREMIARDRQN 2072
>gi|41352705 kinesin family member 3C [Homo sapiens]
Length = 793
Score = 38.1 bits (87), Expect = 0.12
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 1723 GPLSAGGPGKP--GGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRV 1780
GP +AGG P GGGGGG GS + GE + +L N++ L N S+
Sbjct: 257 GPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIP 316
Query: 1781 FHESIL 1786
+ +S L
Sbjct: 317 YRDSKL 322
>gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform b [Homo sapiens]
Length = 373
Score = 36.2 bits (82), Expect = 0.45
Identities = 15/23 (65%), Positives = 17/23 (73%)
Query: 1721 GNGPLSAGGPGKPGGGGGGSGSS 1743
G GP SAGG G GGGGGG G++
Sbjct: 218 GGGPASAGGGGGGGGGGGGGGAA 240
>gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform a [Homo sapiens]
Length = 403
Score = 36.2 bits (82), Expect = 0.45
Identities = 15/23 (65%), Positives = 17/23 (73%)
Query: 1721 GNGPLSAGGPGKPGGGGGGSGSS 1743
G GP SAGG G GGGGGG G++
Sbjct: 218 GGGPASAGGGGGGGGGGGGGGAA 240
>gi|7661968 epsin 4 [Homo sapiens]
Length = 625
Score = 35.4 bits (80), Expect = 0.77
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 10/119 (8%)
Query: 1810 DKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDR--DAPSRKKAKE---P 1864
DK F F D++ +I +T+ S K ++D +R D+ KKA+ P
Sbjct: 189 DKNKSAF--PFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSP 246
Query: 1865 TTQITEE---VRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1920
+ +E V + + + AT T +R A+P G T DKA D S
Sbjct: 247 KGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNAS 305
>gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens]
Length = 407
Score = 34.7 bits (78), Expect = 1.3
Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 7/46 (15%)
Query: 1711 SGRRESLTSFGNG-------PLSAGGPGKPGGGGGGSGSSSMSRGE 1749
+G + L+ FG G P S GGP PG GG +G S RG+
Sbjct: 350 AGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRGQ 395
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [Homo
sapiens]
Length = 969
Score = 34.7 bits (78), Expect = 1.3
Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 2557 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2616
R + KK+ + KT + L FEE +E +++ L + + ++S
Sbjct: 60 RELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLA 119
Query: 2617 TGPESYVAEMI---KERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLS 2673
+ +A ++ KE NL+ +++ ++ D G+Q + E L K + L+
Sbjct: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELN 179
Query: 2674 GQLSELKDQMTEQ--RKQKQRIGLLGHPPHMNVNP 2706
L+ ++++ EQ R+++Q + LL P M V P
Sbjct: 180 QSLA-AQERLVEQLSREKQQLLHLLEEPTSMEVQP 213
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 34.7 bits (78), Expect = 1.3
Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 2557 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2616
R + KK+ + KT + L FEE +E +++ L + + ++S
Sbjct: 60 RELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLA 119
Query: 2617 TGPESYVAEMI---KERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLS 2673
+ +A ++ KE NL+ +++ ++ D G+Q + E L K + L+
Sbjct: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELN 179
Query: 2674 GQLSELKDQMTEQ--RKQKQRIGLLGHPPHMNVNP 2706
L+ ++++ EQ R+++Q + LL P M V P
Sbjct: 180 QSLA-AQERLVEQLSREKQQLLHLLEEPTSMEVQP 213
>gi|29789451 cation channel, sperm associated 3 [Homo sapiens]
Length = 398
Score = 34.7 bits (78), Expect = 1.3
Identities = 21/108 (19%), Positives = 51/108 (47%), Gaps = 5/108 (4%)
Query: 2321 NVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMG-----LFVHEFFYSL 2375
++C + + +V + GY + + + + L Y + MG L++ + SL
Sbjct: 92 SICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSL 151
Query: 2376 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFF 2423
+ L+ + + +I +V + ++ +L +L+Y+F+I+G+ F
Sbjct: 152 RILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 34.7 bits (78), Expect = 1.3
Identities = 18/50 (36%), Positives = 27/50 (54%)
Query: 1826 VAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQ 1875
VA +EIK T+ +D G++K+ + D+D S AK P T RD+
Sbjct: 811 VAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDR 860
>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
Length = 1072
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 1664 LEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNG 1723
+EEN + +L T DR +G G ++L G RR
Sbjct: 152 VEENRPVGTLYLLPT-----ATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPY 206
Query: 1724 PLSAGGPGKPGGGGGGS---------GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMN 1774
P GG G GGG GGS G + G S+ E+Q +G LI+
Sbjct: 207 P-GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ--PQLIVK 263
Query: 1775 ASSDRVFHESILLAIALLEGGN 1796
+ DR +S L + + +GG+
Sbjct: 264 GALDREQRDSYELTLRVRDGGD 285
>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
Length = 1069
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 1664 LEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNG 1723
+EEN + +L T DR +G G ++L G RR
Sbjct: 152 VEENRPVGTLYLLPT-----ATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPY 206
Query: 1724 PLSAGGPGKPGGGGGGS---------GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMN 1774
P GG G GGG GGS G + G S+ E+Q +G LI+
Sbjct: 207 P-GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ--PQLIVK 263
Query: 1775 ASSDRVFHESILLAIALLEGGN 1796
+ DR +S L + + +GG+
Sbjct: 264 GALDREQRDSYELTLRVRDGGD 285
>gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens]
Length = 430
Score = 34.3 bits (77), Expect = 1.7
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 6/56 (10%)
Query: 1703 RYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGG---GGSGSSSMSRGEMSLAEV 1755
R G P G R L P GGPG+P GGG GGSG RG+ + ++
Sbjct: 4 RLLGPPPPGGGRGGLGLVSGEP---GGPGEPPGGGDPGGGSGGVPGGRGKQDIGDI 56
>gi|53729363 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1082 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1141
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1142 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1201
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1202 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1261
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1262 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1321
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1322 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1368
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|53729361 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1082 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1141
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1142 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1201
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1202 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1261
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1262 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1321
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1322 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1368
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|53729359 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1082 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1141
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1142 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1201
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1202 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1261
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1262 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1321
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1322 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1368
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens]
Length = 1215
Score = 34.3 bits (77), Expect = 1.7
Identities = 17/34 (50%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 1710 PSGRRE--SLTSFGNGPLSAGGPGKPGGGGGGSG 1741
P RE +SF G +AGGPG GGGGG+G
Sbjct: 115 PRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAG 148
>gi|157388917 FEZ family zinc finger 2 [Homo sapiens]
Length = 459
Score = 34.3 bits (77), Expect = 1.7
Identities = 18/48 (37%), Positives = 21/48 (43%)
Query: 1710 PSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQC 1757
PS S + L AGG G GGGGGG G + G L + C
Sbjct: 84 PSKTLLSYSELWKSSLRAGGGGGGGGGGGGGGGGAPVCGASGLCKTNC 131
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 33.9 bits (76), Expect = 2.2
Identities = 30/112 (26%), Positives = 51/112 (45%), Gaps = 7/112 (6%)
Query: 1811 KKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRK--KAKEPTTQI 1868
K+ EK +V +E KA T T + + KK++ ++AP K + KEP +
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884
Query: 1869 TEEVRDQLLEASAATRKAFTTFRREA----DPDDHYQPGEGTQATADKAKDD 1916
+E + + + A +K T +EA + + +P E T+ A K DD
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE-VAKKEPDD 935
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 1006 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1054
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1055 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1112
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1113 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1152
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1153 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1209
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1210 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1243
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 1006 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1054
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1055 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1112
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1113 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1152
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1153 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1209
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1210 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1243
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 1006 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1054
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1055 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1112
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1113 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1152
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1153 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1209
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1210 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1243
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,033,979
Number of Sequences: 37866
Number of extensions: 4570229
Number of successful extensions: 19579
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 18472
Number of HSP's gapped (non-prelim): 815
length of query: 2710
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2590
effective length of database: 13,703,598
effective search space: 35492318820
effective search space used: 35492318820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.