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Search of human proteins with 154354996
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354996 inositol 1,4,5-triphosphate receptor, type 1
isoform 2 [Homo sapiens]
(2695 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 5382 0.0
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 5372 0.0
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 3704 0.0
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 3277 0.0
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 166 4e-40
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 166 4e-40
gi|126032338 ryanodine receptor 3 [Homo sapiens] 164 1e-39
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 162 5e-39
gi|71061468 centromere protein E [Homo sapiens] 39 0.090
gi|41352705 kinesin family member 3C [Homo sapiens] 38 0.12
gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homol... 36 0.45
gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolo... 36 0.45
gi|7661968 epsin 4 [Homo sapiens] 35 0.77
gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens] 35 1.3
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 35 1.3
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 35 1.3
gi|29789451 cation channel, sperm associated 3 [Homo sapiens] 35 1.3
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 35 1.3
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens] 34 1.7
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens] 34 1.7
gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens] 34 1.7
gi|53729363 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|53729361 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|53729359 leucine rich repeat and sterile alpha motif containi... 34 1.7
gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens] 34 1.7
gi|157388917 FEZ family zinc finger 2 [Homo sapiens] 34 1.7
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 34 2.2
gi|62243374 MAD1-like 1 protein [Homo sapiens] 34 2.2
gi|62243369 MAD1-like 1 protein [Homo sapiens] 34 2.2
gi|62243332 MAD1-like 1 protein [Homo sapiens] 34 2.2
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 5382 bits (13961), Expect = 0.0
Identities = 2695/2695 (100%), Positives = 2695/2695 (100%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTL 360
SLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTL
Sbjct: 301 SLFRFKHLATGHYLAAEVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTL 360
Query: 361 RGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 420
RGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV
Sbjct: 361 RGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPV 420
Query: 421 SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVL 480
SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVL
Sbjct: 421 SPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVL 480
Query: 481 EVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRL 540
EVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRL
Sbjct: 481 EVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRL 540
Query: 541 CYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI 600
CYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI
Sbjct: 541 CYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEI 600
Query: 601 DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF 660
DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF
Sbjct: 601 DTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF 660
Query: 661 EFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYR 720
EFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYR
Sbjct: 661 EFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYR 720
Query: 721 YQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP 780
YQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP
Sbjct: 721 YQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDP 780
Query: 781 QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPF 840
QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPF
Sbjct: 781 QEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPF 840
Query: 841 SDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEE 900
SDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEE
Sbjct: 841 SDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGEE 900
Query: 901 NKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKI 960
NKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKI
Sbjct: 901 NKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKI 960
Query: 961 IEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIE 1020
IEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIE
Sbjct: 961 IEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALDFEHIE 1020
Query: 1021 EQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVL 1080
EQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVL
Sbjct: 1021 EQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVL 1080
Query: 1081 QAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK 1140
QAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK
Sbjct: 1081 QAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK 1140
Query: 1141 TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVV 1200
TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVV
Sbjct: 1141 TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVV 1200
Query: 1201 LELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQ 1260
LELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQ
Sbjct: 1201 LELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQ 1260
Query: 1261 HIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL 1320
HIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL
Sbjct: 1261 HIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAEL 1320
Query: 1321 VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEI 1380
VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEI
Sbjct: 1321 VNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEI 1380
Query: 1381 KCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFL 1440
KCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFL
Sbjct: 1381 KCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFL 1440
Query: 1441 VDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQG 1500
VDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQG
Sbjct: 1441 VDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQG 1500
Query: 1501 VFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAM 1560
VFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAM
Sbjct: 1501 VFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHSIVQKTAM 1560
Query: 1561 NWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPEL 1620
NWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPEL
Sbjct: 1561 NWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPEL 1620
Query: 1621 LFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEA 1680
LFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEA
Sbjct: 1621 LFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEA 1680
Query: 1681 LRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEV 1740
LRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEV
Sbjct: 1681 LRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEV 1740
Query: 1741 QCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEK 1800
QCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEK
Sbjct: 1741 QCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEK 1800
Query: 1801 FFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQ 1860
FFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQ
Sbjct: 1801 FFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQ 1860
Query: 1861 LLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQL 1920
LLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQL
Sbjct: 1861 LLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQL 1920
Query: 1921 LCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQ 1980
LCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQ
Sbjct: 1921 LCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQ 1980
Query: 1981 TLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKL 2040
TLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKL
Sbjct: 1981 TLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKL 2040
Query: 2041 LLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHN 2100
LLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHN
Sbjct: 2041 LLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHN 2100
Query: 2101 IYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSI 2160
IYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSI
Sbjct: 2101 IYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSI 2160
Query: 2161 CEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSF 2220
CEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSF
Sbjct: 2161 CEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSF 2220
Query: 2221 WSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRA 2280
WSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRA
Sbjct: 2221 WSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRA 2280
Query: 2281 LIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYH 2340
LIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYH
Sbjct: 2281 LIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYH 2340
Query: 2341 LLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLF 2400
LLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLF
Sbjct: 2341 LLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLF 2400
Query: 2401 SIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELV 2460
SIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELV
Sbjct: 2401 SIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELV 2460
Query: 2461 PAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFF 2520
PAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFF
Sbjct: 2461 PAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFF 2520
Query: 2521 MVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEE 2580
MVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEE
Sbjct: 2521 MVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEE 2580
Query: 2581 HNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNEL 2640
HNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNEL
Sbjct: 2581 HNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNEL 2640
Query: 2641 RNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA 2695
RNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA
Sbjct: 2641 RNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA 2695
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 5372 bits (13935), Expect = 0.0
Identities = 2695/2710 (99%), Positives = 2695/2710 (99%), Gaps = 15/2710 (0%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPD---------------QDASRSRLRNAQEKMVYSLVSVPE 345
SLFRFKHLATGHYLAAEVDPD QDASRSRLRNAQEKMVYSLVSVPE
Sbjct: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
Query: 346 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 405
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
Sbjct: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
Query: 406 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 465
SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
Sbjct: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
Query: 466 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 525
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
Sbjct: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE 540
Query: 526 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 585
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
Sbjct: 541 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 600
Query: 586 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 645
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
Sbjct: 601 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 660
Query: 646 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 705
NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
Sbjct: 661 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 720
Query: 706 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 765
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA
Sbjct: 721 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 780
Query: 766 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 825
SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF
Sbjct: 781 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF 840
Query: 826 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 885
VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
Sbjct: 841 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH 900
Query: 886 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 945
VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE
Sbjct: 901 VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE 960
Query: 946 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1005
PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE
Sbjct: 961 PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE 1020
Query: 1006 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1065
GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA
Sbjct: 1021 GPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA 1080
Query: 1066 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1125
LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP
Sbjct: 1081 LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP 1140
Query: 1126 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1185
DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK
Sbjct: 1141 DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK 1200
Query: 1186 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1245
QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI
Sbjct: 1201 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1260
Query: 1246 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1305
NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE
Sbjct: 1261 NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE 1320
Query: 1306 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1365
GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE
Sbjct: 1321 GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE 1380
Query: 1366 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1425
LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE
Sbjct: 1381 LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE 1440
Query: 1426 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1485
IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST
Sbjct: 1441 IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST 1500
Query: 1486 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1545
TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN
Sbjct: 1501 TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN 1560
Query: 1546 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1605
NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ
Sbjct: 1561 NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ 1620
Query: 1606 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1665
AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR
Sbjct: 1621 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR 1680
Query: 1666 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1725
EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS
Sbjct: 1681 EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS 1740
Query: 1726 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1785
GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ
Sbjct: 1741 GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ 1800
Query: 1786 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1845
HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK
Sbjct: 1801 HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK 1860
Query: 1846 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1905
AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS
Sbjct: 1861 AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1920
Query: 1906 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1965
AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL
Sbjct: 1921 AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL 1980
Query: 1966 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2025
LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK
Sbjct: 1981 LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK 2040
Query: 2026 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2085
RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE
Sbjct: 2041 RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE 2100
Query: 2086 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2145
NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR
Sbjct: 2101 NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR 2160
Query: 2146 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2205
LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL
Sbjct: 2161 LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL 2220
Query: 2206 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2265
RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS
Sbjct: 2221 RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS 2280
Query: 2266 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2325
LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT
Sbjct: 2281 LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT 2340
Query: 2326 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2385
RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS
Sbjct: 2341 RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS 2400
Query: 2386 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2445
IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE
Sbjct: 2401 IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE 2460
Query: 2446 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2505
SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE
Sbjct: 2461 SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE 2520
Query: 2506 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2565
PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK
Sbjct: 2521 PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK 2580
Query: 2566 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2625
FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA
Sbjct: 2581 FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA 2640
Query: 2626 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2685
MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP
Sbjct: 2641 MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP 2700
Query: 2686 HMNVNPQQPA 2695
HMNVNPQQPA
Sbjct: 2701 HMNVNPQQPA 2710
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 3704 bits (9606), Expect = 0.0
Identities = 1900/2728 (69%), Positives = 2221/2728 (81%), Gaps = 73/2728 (2%)
Query: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
M++KMSSFL+IGDI SLYAEGS NGFISTLGLVDDRCVV PE GDL NPPKKFRDCLFK+
Sbjct: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
Query: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
CPMNRYSAQKQ+WKA + + T+A LL KL HAA+LE+KQNE+EN+KLLG +++Y NV
Sbjct: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
Query: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
IQLLH+KSNKYLTVNKRLPALLEKNAMRV+LD AGNEGSWFYI PF+KLRS GD++V+GD
Sbjct: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
Query: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
KVVL PVNAGQPLHAS+ +L+DNPGC EVN+VNCNTSWKI LFMK+S ++D+LKGGDVV
Sbjct: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
RLFHAEQEKFLTCDE+ KKQH+FLRTT RQSATSATSSKALWE+EVV HDPCRGGAG WN
Sbjct: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
Query: 301 SLFRFKHLATGHYLAAEVDPD-QDASRS-------------RLRNAQEKMVYSLVSVPEG 346
SLFRFKHLATG+YLAAE++PD +DA + R A EK++Y+LVSVP G
Sbjct: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG 360
Query: 347 NDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTS 406
NDI+S+FELD TTL+ D LVPRNSYVRLRHLCTNTWV ST+IPID +EE+PVMLKIGT
Sbjct: 361 NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC 420
Query: 407 PVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLV 466
KEDKEAFAIV V +EVRDLDFANDA+KVL + KLE GTITQNERR VTKLLEDL+
Sbjct: 421 QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI 480
Query: 467 YFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEE 525
+FV N+GQ+VL+VV +KPNRERQKLMREQNIL Q+F +L+APF + G+G MLRLE+
Sbjct: 481 FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED 540
Query: 526 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 585
LGDQR+AP++++ RLCYRVLRHSQQDYRKNQEYIAK F MQ QIGYD+LAEDTITALLH
Sbjct: 541 LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH 600
Query: 586 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 645
NNRKLLEKHITA EI+TFVSL+R+NREPRFLDYLSDLCVS +IPVTQELICK +L+P
Sbjct: 601 NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG 660
Query: 646 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 705
NADILI+TK+V + + SS L D+EEVWL+W DSNKE K++R LAQ+A
Sbjct: 661 NADILIQTKVVSMQADNPMESSI----LSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEA 716
Query: 706 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 765
KEG K D +VL+YYRYQLNLFARMCLDRQYLAIN+IS QL VDLILRC+SDE+LP+DLRA
Sbjct: 717 KEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRA 776
Query: 766 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS-SGASKDEIKERFAQTME 824
SFCRLMLHMHVDRDPQE V PV+YARLW+EIP++I I +YDS + +S++++K +FA TME
Sbjct: 777 SFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTME 836
Query: 825 FVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 884
FVEEYL++VV Q FPF DKEKNKLTFEVV+LARNLIYFGFY+FS+LLRLT+ LLAILD V
Sbjct: 837 FVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIV 896
Query: 885 HVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNV-KQ 943
+++K ++ G+NVMR+IHGVGE+MTQ+VL G PM+ P + KQ
Sbjct: 897 QAPMSSYFERLSKFQDG-GNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQ 955
Query: 944 AEP-EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNS 1002
P E ED+ VMDTKLKIIEILQFIL+VRLDYRIS +L I+K+EF E N ++SG+
Sbjct: 956 GSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSP 1015
Query: 1003 SQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLV 1062
PS + D + I QAE +F GRKE P+ LDD GGRTFLRVL+HL MHDYPPL+
Sbjct: 1016 DTLLPSAI--VPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLL 1073
Query: 1063 SGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKG 1122
SGALQLLF+HFSQR EVLQAFKQVQLLV++QDVDNYKQIK DLDQLR VEKSELWV K
Sbjct: 1074 SGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKS 1133
Query: 1123 QGPDETMDGASGENEHKKTEE-------------GNNKPQKHESTSSYNYRVVKEILIRL 1169
+ +G GE++ K EE G KPQ +S S NYR+VKEILIRL
Sbjct: 1134 SNYE---NGEIGESQVKGGEEPIEESNILSPVQDGTKKPQI-DSNKSNNYRIVKEILIRL 1189
Query: 1170 SKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQN 1229
SKLCVQ +K R Q QRLL+NMGAH+VVL+LLQIPYEK D KM E+M LAH FLQN
Sbjct: 1190 SKLCVQN----KKCRNQHQRLLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQN 1244
Query: 1230 FCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHG 1289
FC GN QNQ LLHKH+NLFL PG+LEA TM+HIFMNN+ LC+EI+ERVVQHFVHCIETHG
Sbjct: 1245 FCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHG 1304
Query: 1290 RNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD 1349
R+V+Y++FLQTIVKA+GK++KKCQDMVM EL+N GEDVL+FYNDRASF L+ MM SERD
Sbjct: 1305 RHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERD 1364
Query: 1350 RMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYI 1409
R DE+ PL YHI LVELLA CTEGKNVYTEIKCNSLLPLDDIVRVVTH+DCIPEVKIAY+
Sbjct: 1365 RGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYV 1424
Query: 1410 NFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVM 1469
NF+NHCYVDTEVEMKEIYTSNH+WKLFENFLVD+ R CN T+DRKHAD LEK VTE +M
Sbjct: 1425 NFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIM 1484
Query: 1470 SIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVA 1529
+IV+ FF+SPFSD ST+LQT QPVF+QLLQ FR+Y+C W P+QKASVESCIR L++VA
Sbjct: 1485 NIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVA 1544
Query: 1530 KSRAIAIPVDLDSQVNNLFLKSHS-IVQKTAMNWRLSARNAAR-RDSVLAASRDYRNIIE 1587
K+R IAIPVDLDSQVN LF+KSHS +VQ+ AM WRLSAR+ R ++++ + DYRNIIE
Sbjct: 1545 KNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIE 1604
Query: 1588 RLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQ 1647
+LQD+V++LE + P++QAE SVLVDVL+ PELLFPE +DAR +C G F+ KLI HTK+
Sbjct: 1605 KLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKK 1662
Query: 1648 LLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGN 1707
L+E+ EEKLCIK+LQTLREM+ K + E+G LR++L+NRY+ G N
Sbjct: 1663 LMEK-EEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIG--------VN 1713
Query: 1708 GPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFH 1767
G LS GG SG S G +S++++QC LDKEGAS LVID+I+N +DR+F
Sbjct: 1714 GHLSGAYSKTAQVGGSFSGQDSDKMG-ISMSDIQCLLDKEGASELVIDVIVNTKNDRIFS 1772
Query: 1768 ESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDL 1827
E I L IALLEGGNT Q+SF+ +L E KKSEKFFKV YDRMK AQ+EI++TVTVNT DL
Sbjct: 1773 EGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDL 1832
Query: 1828 GNKKKDDEVD-RDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DHY 1885
GNKK+DD+ + + R + ++ T + E ++ QL EAS+AT KA+ +RRE DP+ D
Sbjct: 1833 GNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIM 1892
Query: 1886 QPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLV 1945
G T +K+ +++ MS I IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNLV
Sbjct: 1893 CTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLV 1952
Query: 1946 CETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHES 2005
CETLQFLDCICGSTTGGLGLLGLYINEKNVAL+NQ LESLTEYCQGPCHENQ CIATHES
Sbjct: 1953 CETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHES 2012
Query: 2006 NGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKE 2065
NGIDII ALILNDINPLGK RMDLVL+LKNNASKLLLAIMESRHDSENAERIL+NMRP+E
Sbjct: 2013 NGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRE 2072
Query: 2066 LVEVIKKAYMQG-EVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQ 2124
LV+V+K AY QG E + D E G+DG SP++VGHNIYILAHQLARHNK LQ MLKPG
Sbjct: 2073 LVDVMKNAYNQGLECDHGDDEGGDDG-VSPKDVGHNIYILAHQLARHNKLLQQMLKPGSD 2131
Query: 2125 VD-GDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGS 2183
D GDEAL++YA HTAQIEIVR DRTMEQIVFPVP+ICE+LT+ESK R++ TTERDEQGS
Sbjct: 2132 PDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGS 2191
Query: 2184 KINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFK 2243
K+NDFF ++EDL+NEM WQKK+R P L+W +R++S W SISFNLAV +NL VA FYPF
Sbjct: 2192 KVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF- 2250
Query: 2244 GVRG--GTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFL 2301
G G GTL P +S LLW A+ I +++ KP GIR + S +LR I+++GL PTL L
Sbjct: 2251 GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLIL 2310
Query: 2302 LGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLL 2361
LGA N+CNKI+FL+SFVGN GTFTRGYRA++LD+ FLYH+ Y+++C +GLFVHEFFYS L
Sbjct: 2311 LGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFL 2370
Query: 2362 LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPN 2421
LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSI+G+LF KDDF +EVDRL N
Sbjct: 2371 LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKN 2430
Query: 2422 ETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIV 2481
T P TG + + + ENCS P EE E E TC+TLLMCIV
Sbjct: 2431 RT--PVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTAD-EEYEDGIERTCDTLLMCIV 2487
Query: 2482 TVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADL 2541
TVL+ GLR+GGGVGDVLR+PSK+EPLFAARV+YDLLF+F+VIIIVLNLIFGVIIDTFADL
Sbjct: 2488 TVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADL 2547
Query: 2542 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2601
RSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EHNMWHYL FIVLVKVKD TEY
Sbjct: 2548 RSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEY 2607
Query: 2602 TGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQL 2661
TGPESYVA+MI E+NLDWFPRMRAMSLVS++ + EQNE+R+LQEKLESTM LV LSGQL
Sbjct: 2608 TGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQL 2667
Query: 2662 SELKDQMTEQRKQKQRIGLLG-HPPHMN 2688
+ELK+QMTEQRK KQR+G LG + PH+N
Sbjct: 2668 AELKEQMTEQRKNKQRLGFLGSNTPHVN 2695
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 3277 bits (8496), Expect = 0.0
Identities = 1702/2740 (62%), Positives = 2083/2740 (76%), Gaps = 141/2740 (5%)
Query: 4 KMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPM 63
+MSSFLHIGDI SLYAEGS NGFISTLGLVDDRCVV+P GDL+NPPKKFRDCLFK+CPM
Sbjct: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
Query: 64 NRYSAQKQFWKA--AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVI 121
NRYSAQKQ+WKA K D VLL KL HAA +E+KQN+TEN+K+ G V++YG+VI
Sbjct: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
Query: 122 QLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDK 181
QLLH+KSNKYLTVNKRLPALLEKNAMRVTLD GNEGSW +IQPF+KLRS GD+VV+GDK
Sbjct: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
Query: 182 VVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVR 241
V+LNPVNAGQPLHAS+++L DN GC EVNSVNCNTSWKI LFM++ D+ +++LKGGDVVR
Sbjct: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
Query: 242 LFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNS 301
LFHAEQEKFLTCDE++ K VFLRTT RQSATSATSS ALWEVEVV HDPCRGGAG+WN
Sbjct: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
Query: 302 LFRFKHLATGHYLAAEVDPDQ--DAS-----------RSRLRNAQEKMVYSLVSVPEGND 348
L+RFKHLATG+YLAAE +P DAS R+ RNA EK+ Y LV+VP GND
Sbjct: 303 LYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGND 362
Query: 349 ISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPV 408
I+S+FELDPTTL+ DS VPRNSYVRLRHLCTNTW+ STN+PID EEE+P+ L +GT P
Sbjct: 363 IASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPT 422
Query: 409 KEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYF 468
KEDKEAFAIV V +E+RDLDFANDAS +L S KL +G I+QN+RR V +LLEDLV+F
Sbjct: 423 KEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFF 482
Query: 469 VTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEELG 527
V+ N+GQ+VL+++ +KPNRERQKLMREQNILKQ+F +L+APF + G+GP++RLEEL
Sbjct: 483 VSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEELS 542
Query: 528 DQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNN 587
DQ++AP++H+ RLCYRVLRHSQ+DYRKNQE+IAKQFG MQ QIGYD+LAEDTITALLHNN
Sbjct: 543 DQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNN 602
Query: 588 RKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNA 647
RKLLEKHIT E++TFVSLVRKNREPRFLDYLSDLCVS + +IPVTQELICK VL+P N+
Sbjct: 603 RKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNS 662
Query: 648 DILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKE 707
DILI T+L + + L EEEVWL W D N E KSVR+LAQ+A+
Sbjct: 663 DILIRTELRPVK-----EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARA 717
Query: 708 GQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASF 767
G D +VLSYYRYQL LFARMCLDRQYLAI+EIS QL VDLI CM+DE LP+DLRASF
Sbjct: 718 GNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASF 777
Query: 768 CRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSS-GASKDEIKERFAQTMEFV 826
C LMLH+HVDRDPQE VTPVK+ARLW+EIP+ I I DYDS+ AS+D+ K +FA TMEFV
Sbjct: 778 CHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFV 837
Query: 827 EEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHV 886
E+YL +VV + PF+++EKNKLTFEVV+LA NLIYFGFY+FS+LLRLT+ LL I+DCV
Sbjct: 838 EDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQ- 896
Query: 887 TTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPM----AAAPEGNVK 942
P + + E+ G NV RSI GVG +M+ +VL + P A+A E +
Sbjct: 897 ---GPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDR 953
Query: 943 QAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNS 1002
E EDI+VM+TKLKI+EILQFILNVRLDYRIS LL +FK+EF E + S +
Sbjct: 954 SKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPM--QDSGADG 1011
Query: 1003 SQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLV 1062
+ + ++ + I EQAE +FG K ++ L++DD GGR FLRVL+HLTMHDY PLV
Sbjct: 1012 TAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLV 1071
Query: 1063 SGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYK- 1121
SGALQLLF+HFSQRQE + FKQVQLL+++QDV+NYK IK +LD+LR++VEKSELWV K
Sbjct: 1072 SGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKK 1131
Query: 1122 --GQGPDETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESAS 1179
G+G + A + E EEG P + SS NY++VK IL RL+K+C
Sbjct: 1132 GSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEK--SSENYQIVKGILERLNKMC----GV 1185
Query: 1180 VRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQA 1239
+ RK+QQRLL+NM AH V+L+LLQIPY+K D KM EI+R H+FLQ FCAGN NQA
Sbjct: 1186 GEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKG-DAKMMEILRYTHQFLQKFCAGNPGNQA 1244
Query: 1240 LLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQ 1299
LLHKH++LFL PG+LEA TMQHIF+NN+QLCSEI+E V+QHFVH + THGR+VQY+ FL
Sbjct: 1245 LLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLH 1304
Query: 1300 TIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMY 1359
T++KAEGK++KKCQDM+M EL N+G+DV+VFYND+AS L+ MM++ RD ++++SPLMY
Sbjct: 1305 TVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMY 1364
Query: 1360 HIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDT 1419
HI LV+LLA C EGKNVYTEIKC SLLPL+D+V VVTHEDCI EVK+AY+NF+NHCYVDT
Sbjct: 1365 HISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDT 1424
Query: 1420 EVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSP 1479
EVEMKEIYTSNH+W LFENF +D+ R C+ +++ AD LEKYV +V+ + FFSSP
Sbjct: 1425 EVEMKEIYTSNHIWTLFENFTLDMARVCSK-REKRVADPTLEKYVLSVVLDTINAFFSSP 1483
Query: 1480 FSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVD 1539
FS+ ST+LQT Q + VQLLQ R+ C WL K SVE+CIR L+ VAK RAI +P+D
Sbjct: 1484 FSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMD 1543
Query: 1540 LDSQVNNLFLKSHS---IVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSAL 1596
LD+ ++++ S Q+ A +++ + R A R + A DY+NIIE+LQDI++AL
Sbjct: 1544 LDAHISSMLSSGASCAAAAQRNASSYKATTR-AFPRVTPTANQWDYKNIIEKLQDIITAL 1602
Query: 1597 EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKL 1656
E+RL+PLVQAELSVLVDVLH PELLF E ++A ++CESGGF+ KLI+HTK L+ E+EEKL
Sbjct: 1603 EERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM-ESEEKL 1661
Query: 1657 CIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPG 1716
CIKVL+TL++M+ K YG++G LR++L+ Y N + + R + G G
Sbjct: 1662 CIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTG-------- 1713
Query: 1717 KPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIAL 1776
+ ++A QC LDKEGA+ LV DLI + ++++F ESI LAI L
Sbjct: 1714 -------------LDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHL 1760
Query: 1777 LEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEV 1836
L+GGNT IQ SF + DKKSE+FFKV +DRMK AQQE K+TV VN +DLG++ +D
Sbjct: 1761 LDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED-- 1818
Query: 1837 DRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATAD 1896
++ +PTT+ V + S++ + RR + + Q
Sbjct: 1819 -------REPVDPTTK--GRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSS-------- 1861
Query: 1897 KAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCIC 1956
EM + IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLD +C
Sbjct: 1862 ------EMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMC 1915
Query: 1957 GSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALIL 2016
GSTTGGLGLLGLYINE NV L+ QTLE+LTEYCQGPCHENQ CI THESNGIDIITALIL
Sbjct: 1916 GSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALIL 1975
Query: 2017 NDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQ 2076
NDI+PL K RMDLVL+LK+NASKLLLA+MESRHDSENAERIL ++RP+ELV+VIKKAY+Q
Sbjct: 1976 NDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQ 2035
Query: 2077 GEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEA------ 2130
E+ EN E SPR VGHNIYILA QL+RHNK+LQ +LKP ++ +EA
Sbjct: 2036 E----EERENSE---VSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSM 2088
Query: 2131 -------------------------LEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLT 2165
L +Y HT+QIEIVR DR+MEQIVFPVP IC+FLT
Sbjct: 2089 LSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLT 2148
Query: 2166 KESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSIS 2225
+E+K R++ TTE+DEQGSK++DFF +S L NEM WQ+KLR+ P++YW +R M+ W SIS
Sbjct: 2149 EETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSIS 2208
Query: 2226 FNLAVLMNLLVAFFYPF-KGVRGGTLE-PHWSGLLWTAMLISLAIVIALPKPHGIRALIA 2283
FNLAV +N+++AFFYP+ +G G L+ P S L W +LI +I K + IR LI
Sbjct: 2209 FNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFW--ILICFSIAALFTKRYSIRPLIV 2266
Query: 2284 STILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLY 2343
+ ILR I+ +G+ PTL +LGA N+ NKI+F++SFVGN GTF RGY+AMV+D+EFLYH+ Y
Sbjct: 2267 ALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGY 2326
Query: 2344 LVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIV 2403
++ +GLF HE FYS+LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFSIV
Sbjct: 2327 ILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIV 2386
Query: 2404 GYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGE--NCSSPAPREELVP 2461
G+LF KDDFILEVDRLPN + F D C SG+ +C S E++
Sbjct: 2387 GFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTC---SGDKMDCVSGLSVPEVLE 2443
Query: 2462 AEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFM 2521
+ E C+TLLMCIVTV++HGLR+GGGVGD+LRKPSK+E LF ARV+YDLLFFF+
Sbjct: 2444 EDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFI 2503
Query: 2522 VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEH 2581
VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EH
Sbjct: 2504 VIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEH 2563
Query: 2582 NMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELR 2641
NMW+YL FIVLV+VK+ T+YTGPESYVA+MIK +NLDWFPRMRAMSLVS++ EGEQNE+R
Sbjct: 2564 NMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIR 2623
Query: 2642 NLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2681
LQ+KL STMKLV++L+ QL+ELK+QMTEQRK++QR+G +
Sbjct: 2624 ILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 166 bits (419), Expect = 4e-40
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4782 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4840
Query: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
++VYL+++V + FF+
Sbjct: 4841 AVVVYLYTVVAFNFFR-------------------------------------------- 4856
Query: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E RV+
Sbjct: 4857 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELYRVV 4911
Query: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4912 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4971
Query: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
E H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4972 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5019
Score = 84.0 bits (206), Expect = 2e-15
Identities = 130/580 (22%), Positives = 231/580 (39%), Gaps = 84/580 (14%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
Query: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
Query: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSR-------LRNAQEKMVYSLVS 342
G W R +H+ TG YLA D DAS++ R ++EK+
Sbjct: 269 SGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKL-----D 323
Query: 343 VPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLK 402
V D+ + P ++ G+SL ++H+ + W + P L+
Sbjct: 324 VAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPDPKALR 367
Query: 403 IGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAGKLE-- 446
+G K +A ++ E + N K L S +GK
Sbjct: 368 LGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGS 427
Query: 447 ---KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQ 503
GT E V L+DL+ + + Q + + R RQ L +E+ +L
Sbjct: 428 GPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSM 485
Query: 504 IFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAK 561
+ + +T E G++ ++ I L Y +L + R N +
Sbjct: 486 VLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFST 541
Query: 562 QFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFL 616
++ ++ + E L+ + L I I + +SL+ K+ R + L
Sbjct: 542 NLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGRNHKVL 599
Query: 617 DYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656
D L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 600 DVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
Score = 70.9 bits (172), Expect = 2e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 3761 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3819
Query: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 3820 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3857
Query: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
T R Q GE A + +D + RFL
Sbjct: 3858 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3882
Query: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3883 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3942
Query: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 3943 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4002
Query: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 4003 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4062
Query: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2090
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 4063 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4122
Query: 2091 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 4123 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4177
Query: 2144 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2197
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 4178 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4237
Query: 2198 EM 2199
EM
Sbjct: 4238 EM 4239
Score = 43.9 bits (102), Expect = 0.002
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 1175 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1221
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
Query: 1222 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1273
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
Query: 1274 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1328
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
Score = 32.0 bits (71), Expect = 8.5
Identities = 15/67 (22%), Positives = 33/67 (49%)
Query: 711 EDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRL 770
E D+ ++ + L L+ +C + + +D +L + D +LP LRA + L
Sbjct: 1654 ERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDL 1713
Query: 771 MLHMHVD 777
++ +H++
Sbjct: 1714 LISIHLE 1720
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 166 bits (419), Expect = 4e-40
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
Query: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
++VYL+++V + FF+
Sbjct: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
Query: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E RV+
Sbjct: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELYRVV 4916
Query: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4917 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4976
Query: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
E H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4977 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
Score = 84.0 bits (206), Expect = 2e-15
Identities = 130/580 (22%), Positives = 231/580 (39%), Gaps = 84/580 (14%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
Query: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
Query: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSR-------LRNAQEKMVYSLVS 342
G W R +H+ TG YLA D DAS++ R ++EK+
Sbjct: 269 SGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKL-----D 323
Query: 343 VPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLK 402
V D+ + P ++ G+SL ++H+ + W + P L+
Sbjct: 324 VAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPDPKALR 367
Query: 403 IGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAGKLE-- 446
+G K +A ++ E + N K L S +GK
Sbjct: 368 LGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGS 427
Query: 447 ---KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQ 503
GT E V L+DL+ + + Q + + R RQ L +E+ +L
Sbjct: 428 GPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSM 485
Query: 504 IFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAK 561
+ + +T E G++ ++ I L Y +L + R N +
Sbjct: 486 VLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFST 541
Query: 562 QFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFL 616
++ ++ + E L+ + L I I + +SL+ K+ R + L
Sbjct: 542 NLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGRNHKVL 599
Query: 617 DYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656
D L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 600 DVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
Score = 70.9 bits (172), Expect = 2e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Query: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
Query: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
T R Q GE A + +D + RFL
Sbjct: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
Query: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
Query: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
Query: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
Query: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2090
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
Query: 2091 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
Query: 2144 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2197
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
Query: 2198 EM 2199
EM
Sbjct: 4243 EM 4244
Score = 43.9 bits (102), Expect = 0.002
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 1175 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1221
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
Query: 1222 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1273
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
Query: 1274 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1328
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
Score = 32.0 bits (71), Expect = 8.5
Identities = 15/67 (22%), Positives = 33/67 (49%)
Query: 711 EDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRL 770
E D+ ++ + L L+ +C + + +D +L + D +LP LRA + L
Sbjct: 1654 ERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDL 1713
Query: 771 MLHMHVD 777
++ +H++
Sbjct: 1714 LISIHLE 1720
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 164 bits (414), Expect = 1e-39
Identities = 90/288 (31%), Positives = 151/288 (52%), Gaps = 50/288 (17%)
Query: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
D FLY Y + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
Query: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
++VYL+++V + FF+
Sbjct: 4678 AVVVYLYTVVAFNFFR-------------------------------------------- 4693
Query: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513
+ E + + + C+ ++ C + + G+R+GGG+GD + P+ + P R++
Sbjct: 4694 ----KFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
Query: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573
+D+ FFF VI+I+L +I G+IID F +LR ++++ E ++T CFICG+ D FD F
Sbjct: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
Query: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
Score = 99.4 bits (246), Expect = 4e-20
Identities = 126/558 (22%), Positives = 225/558 (40%), Gaps = 44/558 (7%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ + L H S YLT + +K A V L E A E W+ I P K RS G+
Sbjct: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V IGD ++L V++ + LH S V N G +V++ T W + S ++ L
Sbjct: 165 VRIGDDLILVSVSSERYLHLS----VSN-GNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
Query: 236 GGDVVRLFHAEQEKF-LTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRG 294
GG VVRLFH E + + QH R ++ + T +++LW VE ++ G
Sbjct: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
Query: 295 GAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSRLRNAQEKMVYS--LVSVPEGNDI 349
W FR +HL TGHYLA D QD ++S ++ S L + +
Sbjct: 276 SNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHK 335
Query: 350 SSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVK 409
I + ++ GDS+ ++H+ + WV P+ K+
Sbjct: 336 RDIEGMGVPEIKYGDSV------CFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEG 389
Query: 410 EDKEAFAIVPVSPAEVRDLDFANDASKVLGS-IAGKLEKGTITQNERRSVTKLLEDLVYF 468
+ + E + + + + ++G V + L+DL+ +
Sbjct: 390 HMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAY 449
Query: 469 VTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA--PFTDCGDGPMLRLEEL 526
+ + + + RQ L +E+ +L + + + + EE
Sbjct: 450 FQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREES 509
Query: 527 GDQRHAPFRHICRLCYRVL-------RHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDT 579
G ++ I L Y++L R++ + N +++ + ++ G +
Sbjct: 510 G----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSG----ILEV 561
Query: 580 ITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFLDYLSDLCVSMNKSIPVTQELIC 638
+ +L + + L I I + +SL+ K+ R + LD L LC+ ++ Q LIC
Sbjct: 562 LHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLIC 620
Query: 639 KAVLNPTNADILIETKLV 656
+L N +L++T+L+
Sbjct: 621 DNLLPRRN--LLLQTRLI 636
Score = 79.7 bits (195), Expect = 4e-14
Identities = 110/494 (22%), Positives = 190/494 (38%), Gaps = 140/494 (28%)
Query: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Q L + GA+ +V+ +I + + + E++ L IA+L GGN +Q L E KK
Sbjct: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
Query: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
FF+ M+ + + +N + NK A E T I E
Sbjct: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRERG 3722
Query: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
+++L+ TR F RFL
Sbjct: 3723 EKVLQNDEFTRDLF-------------------------------------------RFL 3739
Query: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
QLLCE HN D QNFLR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3740 QLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQ 3799
Query: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
+ K +A+ Q SLTEY QGPC NQ +A + +S+
Sbjct: 3800 HNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSS 3859
Query: 2007 GIDIITAL--ILNDI--------------NPLGKKRMDLVLELKNNASKLL--------- 2041
I+++ L +L D+ +GK+ +D ++E N +L
Sbjct: 3860 QIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKL 3919
Query: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2087
L ++ + + + + + + + +K Y Q E++F E EN
Sbjct: 3920 KDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDF 3979
Query: 2088 EDGAASP-RNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
D P +++G N+ +L L+ H + L+ +L P + L ++ + +IEI
Sbjct: 3980 VDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP-----AESVLNYFEPYLGRIEI 4034
Query: 2144 VRLDRTMEQIVFPV 2157
+ + +E++ F +
Sbjct: 4035 MGGAKKIERVYFEI 4048
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 162 bits (409), Expect = 5e-39
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
D FLY Y+ + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
Query: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
++VYL+++V + FF+ + E+ +P
Sbjct: 4775 AVVVYLYTVVAFNFFRKFY--------------------------------NKSEDGDTP 4802
Query: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513
+ C+ +L C + + G+R+GGG+GD + P+ +E R+I
Sbjct: 4803 ----------------DMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
Query: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
Query: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER ++FP
Sbjct: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
Score = 95.1 bits (235), Expect = 8e-19
Identities = 138/577 (23%), Positives = 235/577 (40%), Gaps = 79/577 (13%)
Query: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
YG+ I L H S YL + +K A V L E E W+ I P K RS G+
Sbjct: 115 YGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 174
Query: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
V +GD ++L V++ + LH S G V++ T W + S+ L
Sbjct: 175 VRVGDDLILVSVSSERYLHLSY-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLI 229
Query: 236 GGDVVRLFHAEQEKFLT--CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCR 293
GGDV+RL H ++ LT EH ++Q RT + + +++LW +E ++
Sbjct: 230 GGDVLRLLHGHMDECLTVPSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLR-VAWS 285
Query: 294 GGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSRLRNAQEKMVYSLVSVPEGNDIS 350
G W FR +H+ TG YL+ D + D ++ +++ ++ S E D+
Sbjct: 286 GSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKST----AFTFRSSKEKLDVG 341
Query: 351 SIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTW-----VHSTNIPIDKEEEKPVM----- 400
E+D G + +S ++H+ T W V ++ + + K +M
Sbjct: 342 VRKEVDG---MGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGH 398
Query: 401 LKIGTSPVKEDKEAFAIVPVSPAEVRDLDFA-NDASKVLGSIAGKLEKGTITQNERRSVT 459
+ G S + E V +R F N + L +++ K + T+ SV+
Sbjct: 399 MDDGISLSRSQHEESRTARV----IRSTVFLFNRFIRGLDALSKKAKASTV-DLPIESVS 453
Query: 460 KLLEDLV-YFVTGGTNSGQDVLEVVFSKPNR-----ERQKLMREQNILKQIFKLLQ---- 509
L+DL+ YF + + K NR RQ L +E+ ++ + + +
Sbjct: 454 LSLQDLIGYFHPPDEHLEHE------DKQNRLRALKNRQNLFQEEGMINLVLECIDRLHV 507
Query: 510 ----APFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGF 565
A F D G + ++ I Y +L + RKN + +
Sbjct: 508 YSSAAHFADVA----------GREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDW 557
Query: 566 MQKQIGYDVLAEDTITALLHNNRKLLEKH-----ITAAEIDTFVSLVRKN-REPRFLDYL 619
+ ++ + A I +LH L+E I I + +SL+ K+ R + LD L
Sbjct: 558 LISRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVL 614
Query: 620 SDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656
LCV ++ Q LIC +L D+L++T+LV
Sbjct: 615 CSLCVCHGVAVRSNQHLICDNLL--PGRDLLLQTRLV 649
Score = 72.0 bits (175), Expect = 7e-12
Identities = 107/494 (21%), Positives = 183/494 (37%), Gaps = 146/494 (29%)
Query: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Q L GA+ +V+ I + + + ++ L IA+L GGN+T+Q L E KK
Sbjct: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKE-KKD 3786
Query: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
FF+ S G + +D +A R+ E +TEE
Sbjct: 3787 VGFFQ---------------------SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEE-- 3823
Query: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
+ +K D E + + RFL
Sbjct: 3824 ----------------------------------GSGEKVLQDDEFTC------DLFRFL 3843
Query: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 3844 QLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQ 3903
Query: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
K + + Q +LTEY QGPC NQ +A + +S+
Sbjct: 3904 RNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSS 3963
Query: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041
I+++ L+ N +N +GK+ +D+++E NN +L
Sbjct: 3964 QIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKL 4023
Query: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2087
L ++ + + + + + R K Y Q E EF E EN
Sbjct: 4024 KDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEF 4083
Query: 2088 -EDGAASPRNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
+ +++G N+ +L L+ H + LQ+ L+ + L ++ +IEI
Sbjct: 4084 VKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL-----AESVLNYFQPFLGRIEI 4138
Query: 2144 VRLDRTMEQIVFPV 2157
+ + +E++ F +
Sbjct: 4139 MGSAKRIERVYFEI 4152
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 38.5 bits (88), Expect = 0.090
Identities = 59/284 (20%), Positives = 124/284 (43%), Gaps = 24/284 (8%)
Query: 1085 QVQLLVTSQDVDNYKQIKQDL----DQLRSIVEKSELWVYKGQGPDETMDGASGENEHKK 1140
Q ++ +++ DN K IK+ L DQL+ + ++ + + Q E + + + +
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE--QSLNMKEKDNE 1398
Query: 1141 TEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQ---ESASVRKSRKQQQRLLRNMGAH 1197
T + ++ ++ + S R+ E+L LSK + E SV K + QRL + +
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEML-GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 1198 AVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAV 1257
+ L+ I A+ + +E +++AH C +Q + + +NL + +
Sbjct: 1458 SDQLKE-NIKEIVAKHLETEEELKVAH------CCLKEQEETINELRVNLSEKETEISTI 1510
Query: 1258 TMQHIFMNNF--QLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDM 1315
Q +N+ EI E+ Q + I V +K + KA+ ++ +
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 1316 VMAELVN----SGEDVLVFYNDRASFQTLIQMMRSERDRMDENS 1355
M EL N S E++ + ++ + + + ++ ERD++ EN+
Sbjct: 1571 -MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613
Score = 37.0 bits (84), Expect = 0.26
Identities = 50/260 (19%), Positives = 113/260 (43%), Gaps = 20/260 (7%)
Query: 1077 QEVLQAFK--QVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASG 1134
QE +Q K + QL+ +DV+ ++ +++QL+ ++ L + K + + +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 1135 EN--EHKKTEEGNNKPQKHESTSSYNYRVVKEIL--IRLSKLCVQESASV-----RKSRK 1185
EN E K + + ++ E T +KE L + L +Q+ ++ ++
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Query: 1186 QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI 1245
+L + + + +Q +K++D ++I L + LQ N + HK I
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS--HKKI 1996
Query: 1246 N---LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIV 1302
N + ++MQ + M+NFQL +++E + + + + ++ IK +++
Sbjct: 1997 NEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE--IRIVAKERDELRRIK--ESLK 2052
Query: 1303 KAEGKFIKKCQDMVMAELVN 1322
+FI ++M+ + N
Sbjct: 2053 MERDQFIATLREMIARDRQN 2072
>gi|41352705 kinesin family member 3C [Homo sapiens]
Length = 793
Score = 38.1 bits (87), Expect = 0.12
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 1708 GPLSAGGPGKP--GGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRV 1765
GP +AGG P GGGGGG GS + GE + +L N++ L N S+
Sbjct: 257 GPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIP 316
Query: 1766 FHESIL 1771
+ +S L
Sbjct: 317 YRDSKL 322
>gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform b [Homo sapiens]
Length = 373
Score = 36.2 bits (82), Expect = 0.45
Identities = 15/23 (65%), Positives = 17/23 (73%)
Query: 1706 GNGPLSAGGPGKPGGGGGGSGSS 1728
G GP SAGG G GGGGGG G++
Sbjct: 218 GGGPASAGGGGGGGGGGGGGGAA 240
>gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform a [Homo sapiens]
Length = 403
Score = 36.2 bits (82), Expect = 0.45
Identities = 15/23 (65%), Positives = 17/23 (73%)
Query: 1706 GNGPLSAGGPGKPGGGGGGSGSS 1728
G GP SAGG G GGGGGG G++
Sbjct: 218 GGGPASAGGGGGGGGGGGGGGAA 240
>gi|7661968 epsin 4 [Homo sapiens]
Length = 625
Score = 35.4 bits (80), Expect = 0.77
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 10/119 (8%)
Query: 1795 DKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDR--DAPSRKKAKE---P 1849
DK F F D++ +I +T+ S K ++D +R D+ KKA+ P
Sbjct: 189 DKNKSAF--PFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSP 246
Query: 1850 TTQITEE---VRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS 1905
+ +E V + + + AT T +R A+P G T DKA D S
Sbjct: 247 KGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNAS 305
>gi|25470886 DAZ associated protein 1 isoform b [Homo sapiens]
Length = 407
Score = 34.7 bits (78), Expect = 1.3
Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 7/46 (15%)
Query: 1696 SGRRESLTSFGNG-------PLSAGGPGKPGGGGGGSGSSSMSRGE 1734
+G + L+ FG G P S GGP PG GG +G S RG+
Sbjct: 350 AGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRGQ 395
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [Homo
sapiens]
Length = 969
Score = 34.7 bits (78), Expect = 1.3
Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 2542 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2601
R + KK+ + KT + L FEE +E +++ L + + ++S
Sbjct: 60 RELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLA 119
Query: 2602 TGPESYVAEMI---KERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLS 2658
+ +A ++ KE NL+ +++ ++ D G+Q + E L K + L+
Sbjct: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELN 179
Query: 2659 GQLSELKDQMTEQ--RKQKQRIGLLGHPPHMNVNP 2691
L+ ++++ EQ R+++Q + LL P M V P
Sbjct: 180 QSLA-AQERLVEQLSREKQQLLHLLEEPTSMEVQP 213
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 34.7 bits (78), Expect = 1.3
Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 2542 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2601
R + KK+ + KT + L FEE +E +++ L + + ++S
Sbjct: 60 RELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLA 119
Query: 2602 TGPESYVAEMI---KERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLS 2658
+ +A ++ KE NL+ +++ ++ D G+Q + E L K + L+
Sbjct: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELN 179
Query: 2659 GQLSELKDQMTEQ--RKQKQRIGLLGHPPHMNVNP 2691
L+ ++++ EQ R+++Q + LL P M V P
Sbjct: 180 QSLA-AQERLVEQLSREKQQLLHLLEEPTSMEVQP 213
>gi|29789451 cation channel, sperm associated 3 [Homo sapiens]
Length = 398
Score = 34.7 bits (78), Expect = 1.3
Identities = 21/108 (19%), Positives = 51/108 (47%), Gaps = 5/108 (4%)
Query: 2306 NVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMG-----LFVHEFFYSL 2360
++C + + +V + GY + + + + L Y + MG L++ + SL
Sbjct: 92 SICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSL 151
Query: 2361 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFF 2408
+ L+ + + +I +V + ++ +L +L+Y+F+I+G+ F
Sbjct: 152 RILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 34.7 bits (78), Expect = 1.3
Identities = 18/50 (36%), Positives = 27/50 (54%)
Query: 1811 VAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQ 1860
VA +EIK T+ +D G++K+ + D+D S AK P T RD+
Sbjct: 811 VAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDR 860
>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
Length = 1072
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 1649 LEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNG 1708
+EEN + +L T DR +G G ++L G RR
Sbjct: 152 VEENRPVGTLYLLPT-----ATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPY 206
Query: 1709 PLSAGGPGKPGGGGGGS---------GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMN 1759
P GG G GGG GGS G + G S+ E+Q +G LI+
Sbjct: 207 P-GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ--PQLIVK 263
Query: 1760 ASSDRVFHESILLAIALLEGGN 1781
+ DR +S L + + +GG+
Sbjct: 264 GALDREQRDSYELTLRVRDGGD 285
>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
Length = 1069
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 1649 LEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNG 1708
+EEN + +L T DR +G G ++L G RR
Sbjct: 152 VEENRPVGTLYLLPT-----ATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPY 206
Query: 1709 PLSAGGPGKPGGGGGGS---------GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMN 1759
P GG G GGG GGS G + G S+ E+Q +G LI+
Sbjct: 207 P-GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ--PQLIVK 263
Query: 1760 ASSDRVFHESILLAIALLEGGN 1781
+ DR +S L + + +GG+
Sbjct: 264 GALDREQRDSYELTLRVRDGGD 285
>gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens]
Length = 430
Score = 34.3 bits (77), Expect = 1.7
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 6/56 (10%)
Query: 1688 RYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGG---GGSGSSSMSRGEMSLAEV 1740
R G P G R L P GGPG+P GGG GGSG RG+ + ++
Sbjct: 4 RLLGPPPPGGGRGGLGLVSGEP---GGPGEPPGGGDPGGGSGGVPGGRGKQDIGDI 56
>gi|53729363 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1067 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1126
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1127 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1186
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1187 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1246
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1247 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1306
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1307 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1353
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|53729361 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1067 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1126
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1127 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1186
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1187 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1246
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1247 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1306
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1307 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1353
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|53729359 leucine rich repeat and sterile alpha motif containing 1
[Homo sapiens]
Length = 723
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/287 (18%), Positives = 116/287 (40%), Gaps = 42/287 (14%)
Query: 1067 QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD 1126
QLL + SQ+ E+LQ K+ Q + ++ + + + +L+ ++++E Q
Sbjct: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTE------QNIS 336
Query: 1127 ETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ 1186
+ +N+ +K K S N R+ E L+ +++ +E+ S+R R+
Sbjct: 337 SRIQKLLQDNQRQKKSSEILK-------SLENERIRMEQLMSITQ---EETESLR--RRD 384
Query: 1187 QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN 1246
++ M + L+Q+ YE +Q+ E + F Q +K I+
Sbjct: 385 VASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAIS 444
Query: 1247 LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG 1306
IL+ MQ Q+ ++ R ++ + IET + ++ Q +K +
Sbjct: 445 -----QILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET-----ELLQLTQLELKRKS 494
Query: 1307 KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDE 1353
+ Q+M+ + R + +L+Q + E+ + +E
Sbjct: 495 LDTESLQEMISEQ--------------RWALSSLLQQLLKEKQQREE 527
>gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens]
Length = 1215
Score = 34.3 bits (77), Expect = 1.7
Identities = 17/34 (50%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 1695 PSGRRE--SLTSFGNGPLSAGGPGKPGGGGGGSG 1726
P RE +SF G +AGGPG GGGGG+G
Sbjct: 115 PRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAG 148
>gi|157388917 FEZ family zinc finger 2 [Homo sapiens]
Length = 459
Score = 34.3 bits (77), Expect = 1.7
Identities = 18/48 (37%), Positives = 21/48 (43%)
Query: 1695 PSGRRESLTSFGNGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQC 1742
PS S + L AGG G GGGGGG G + G L + C
Sbjct: 84 PSKTLLSYSELWKSSLRAGGGGGGGGGGGGGGGGAPVCGASGLCKTNC 131
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 33.9 bits (76), Expect = 2.2
Identities = 30/112 (26%), Positives = 51/112 (45%), Gaps = 7/112 (6%)
Query: 1796 KKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRK--KAKEPTTQI 1853
K+ EK +V +E KA T T + + KK++ ++AP K + KEP +
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884
Query: 1854 TEEVRDQLLEASAATRKAFTTFRREA----DPDDHYQPGEGTQATADKAKDD 1901
+E + + + A +K T +EA + + +P E T+ A K DD
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE-VAKKEPDD 935
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 991 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1039
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1040 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1097
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1098 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1137
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1138 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1194
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1195 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1228
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 991 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1039
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1040 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1097
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1098 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1137
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1138 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1194
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1195 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1228
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 33.9 bits (76), Expect = 2.2
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 43/274 (15%)
Query: 991 NSQTSETSSGNSSQEGPSNVPGALDFEH-----IEEQAEGIFGG------RKENTPLDLD 1039
N+ S+ G S + ++ PG+L ++ +EE+AE I +E ++L
Sbjct: 18 NNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELS 77
Query: 1040 DHGGRTFLRVLLHLTMHDYPPLVSGALQLL--FRHFSQRQEVLQAFKQVQLLVTSQDVDN 1097
R L + +Y V +LL R +R+ + Q QL Q N
Sbjct: 78 HKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN 137
Query: 1098 Y----KQIKQDLDQLRSIVE-----KSELWVYKGQGPDETMDGASGENE----------- 1137
K++++ D L E K + + D+ M E+E
Sbjct: 138 LDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
Query: 1138 HKKTEEGNNKPQKHESTS---SYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNM 1194
HKK +E N K Q+ +++ + + + +K++ +LS L Q++A V+ + + RL R
Sbjct: 198 HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS-LQEQDAAIVKNMKSELVRLPR-- 254
Query: 1195 GAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1228
+ EL Q+ E A +M+E L E L+
Sbjct: 255 ----LERELKQLREESAHLREMRETNGLLQEELE 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,145,600
Number of Sequences: 37866
Number of extensions: 4512669
Number of successful extensions: 19448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 18335
Number of HSP's gapped (non-prelim): 821
length of query: 2695
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2575
effective length of database: 13,703,598
effective search space: 35286764850
effective search space used: 35286764850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.