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Search of human proteins with 154350226
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo
sapiens]
(1140 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 2202 0.0
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 1838 0.0
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 377 e-104
gi|71061468 centromere protein E [Homo sapiens] 176 1e-43
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 170 8e-42
gi|38044112 restin isoform b [Homo sapiens] 167 7e-41
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 160 5e-39
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 159 1e-38
gi|21735548 centrosomal protein 2 [Homo sapiens] 154 4e-37
gi|4506751 restin isoform a [Homo sapiens] 154 4e-37
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 154 4e-37
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 154 4e-37
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 154 4e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 154 5e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 154 5e-37
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 154 5e-37
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 154 5e-37
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 150 9e-36
gi|148746195 trichohyalin [Homo sapiens] 149 1e-35
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 149 1e-35
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 149 1e-35
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 149 1e-35
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 149 1e-35
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 149 1e-35
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 149 1e-35
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 149 1e-35
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 149 1e-35
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 147 6e-35
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 147 6e-35
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 146 1e-34
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 2202 bits (5707), Expect = 0.0
Identities = 1140/1140 (100%), Positives = 1140/1140 (100%)
Query: 1 MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNT 60
MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNT
Sbjct: 1 MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNT 60
Query: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIK 120
KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIK
Sbjct: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIK 120
Query: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE
Sbjct: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
Query: 181 KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 240
KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE
Sbjct: 181 KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 240
Query: 241 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 300
RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK
Sbjct: 241 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 300
Query: 301 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 360
TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE
Sbjct: 301 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 360
Query: 361 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420
VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE
Sbjct: 361 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420
Query: 421 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480
RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS
Sbjct: 421 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480
Query: 481 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 540
KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV
Sbjct: 481 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 540
Query: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA
Sbjct: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
Query: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 660
LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH
Sbjct: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 660
Query: 661 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 720
EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA
Sbjct: 661 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 720
Query: 721 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780
QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE
Sbjct: 721 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780
Query: 781 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 840
LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH
Sbjct: 781 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 840
Query: 841 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 900
HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL
Sbjct: 841 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 900
Query: 901 TKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNE 960
TKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNE
Sbjct: 901 TKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNE 960
Query: 961 LLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 1020
LLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE
Sbjct: 961 LLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 1020
Query: 1021 LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 1080
LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR
Sbjct: 1021 LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 1080
Query: 1081 LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 1140
LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF
Sbjct: 1081 LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 1140
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 1838 bits (4761), Expect = 0.0
Identities = 966/1020 (94%), Positives = 968/1020 (94%), Gaps = 49/1020 (4%)
Query: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE
Sbjct: 1 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
Query: 181 KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 240
KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE
Sbjct: 61 KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
Query: 241 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 300
RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK
Sbjct: 121 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
Query: 301 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 360
TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE
Sbjct: 181 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240
Query: 361 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420
VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE
Sbjct: 241 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 300
Query: 421 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480
RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS
Sbjct: 301 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 360
Query: 481 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 540
KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV
Sbjct: 361 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 420
Query: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA
Sbjct: 421 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 480
Query: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 660
LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH
Sbjct: 481 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540
Query: 661 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 720
EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA
Sbjct: 541 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600
Query: 721 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780
QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE
Sbjct: 601 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 660
Query: 781 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 840
LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH
Sbjct: 661 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 720
Query: 841 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 900
HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL
Sbjct: 721 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
Query: 901 TKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNE 960
TKELEFKGKEILRIRSESNQQIRL E + EK +MR
Sbjct: 781 TKELEFKGKEILRIRSESNQQIRLEE------------------MEEKYLMR-------- 814
Query: 961 LLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 1020
ESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE
Sbjct: 815 -----------------------ESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 851
Query: 1021 LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 1080
LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR
Sbjct: 852 LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 911
Query: 1081 LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 1140
LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF
Sbjct: 912 LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 971
Score = 98.6 bits (244), Expect = 3e-20
Identities = 129/616 (20%), Positives = 268/616 (43%), Gaps = 108/616 (17%)
Query: 72 LKDAHEEE--IQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEF 129
+KD E+ + + L++ E+ +SK T+ LD +K Q+LE LE K+ + T+
Sbjct: 280 IKDLESEKSRVNERLSQLEEERAFLRSK-TQSLDEEQKQQILE--LEK--KVNEAKRTQQ 334
Query: 130 EAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALED 189
E Y+ ++++Q E + Q S+ +EE+ K +A+E
Sbjct: 335 EYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWK------------------HHMAIE- 375
Query: 190 LQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYE 249
A H I++ K Q D EE H + +L + +L+ E + L E E
Sbjct: 376 --AVHSNAIRDKKKLQMD-----------LEEQHNKDKLNLEEDKNQLQQELENLKEVLE 422
Query: 250 GKLNKAQSFYERELDTLKRSQ--LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKT 307
KLN A D +++S+ L +AE L AS L+
Sbjct: 423 DKLNTANQEIGHLQDMVRKSEQGLGSAEGLIAS------------------------LQD 458
Query: 308 ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAA 367
+ +Q+E D ++ + AL E ++ ++Q ++ ++ KE E
Sbjct: 459 SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEET-------IAAMKEEE----- 506
Query: 368 ARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSK 427
+ ++ + A DL +K + + +++ +E+ ++ E +KS +++ L + E+ R
Sbjct: 507 -KLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 565
Query: 428 TQSLDEEQKQQILELEKKVN---EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLE 484
Q E+ QI L++ + +T + + + + RL +E+ +L E H + +
Sbjct: 566 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
Query: 485 ELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKD--------KLNLEEDKNQLQQELEN 536
L H +A + + ++++ L+ L+++H+ + + ++E + +++QEL+
Sbjct: 626 SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
Query: 537 LKEVLEDK----LNTANQEIGHLQ----DMVRKSEQGLGSAEGLIASLQDSQERLQNELD 588
L+ LED+ L + E+ H D++R + L ++ L+ +D
Sbjct: 686 LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH---------QELAAAKMELERSID 736
Query: 589 LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE 648
+++ KE + +++ EL + R+ H + + + + +LE K E LR
Sbjct: 737 ISRRQSKEHICRITDLQEEL-RHREHHISELDKEVQHLHENISALTKELEFKGKEILRIR 795
Query: 649 CSKLREELRLQHEEDK 664
S+ +++RL+ E+K
Sbjct: 796 -SESNQQIRLEEMEEK 810
Score = 41.2 bits (95), Expect = 0.006
Identities = 47/215 (21%), Positives = 97/215 (45%), Gaps = 23/215 (10%)
Query: 59 NTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDH 118
N +H + +Q+LKDAH E ++ E +++ T +L + + + +SL
Sbjct: 651 NHLQQKHSAELQSLKDAHRESMEGFRIEMEQEL------QTLRFELEDEGKAMLASLRSE 704
Query: 119 IKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSR--EVEEIRR--KFEEKLRSFGQ 174
+ + A + + H E L A ++R + +SR E I R +E+LR
Sbjct: 705 LNHQHAAAIDLLRHNHHQE---LAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH 761
Query: 175 LQVQFEKDKRLALEDLQAAHRR---EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLN 231
+ +K+ + E++ A + + +E+L+ + + + + + + + L R
Sbjct: 762 HISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDI 821
Query: 232 KMLEELR---LERKKLIEDYEGKLNKAQSFYEREL 263
+M+ EL+ ER ++I+ KL + FY+ EL
Sbjct: 822 QMITELKAMLTERDQIIK----KLIEDNKFYQLEL 852
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 377 bits (969), Expect = e-104
Identities = 309/1141 (27%), Positives = 546/1141 (47%), Gaps = 134/1141 (11%)
Query: 30 AGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETRE 89
AG MD +MH+KM KKIAQLTKVIYALNT+ DE E++++AL++AH+EE+Q +AET+
Sbjct: 24 AGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKA 83
Query: 90 KILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQ 149
++LQ + EE L+R IQ LES+LE ++ ++AL E + + ++ +L EA+H +
Sbjct: 84 RLLQEQGCAEEEALLQR-IQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAE 142
Query: 150 RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHS 209
R++T+SRE+ E++ +E +L+ +H Q L +
Sbjct: 143 RVLTLSREMLELKADYERRLQHL-------------------TSHEATPQGRLPQESP-- 181
Query: 210 ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
+ K+E E++ + ++ LR+E ++L +DY K + Q+ YERE + ++++
Sbjct: 182 ------ETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQA 235
Query: 270 -QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQT 328
Q +++L +EKE+DLRK FQ QE+ L+ + KL+ +L+ + L QKL
Sbjct: 236 MQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKL-- 293
Query: 329 ALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGM 388
+ +Q L QL +A++ L K++ +LA A++R+ M
Sbjct: 294 -----KERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRM---------------M 333
Query: 389 LQATQMTQEVTIKDLE-SEKSRVNERLSQLEEERAFLRSKTQSLDE---EQKQQILELEK 444
LQ + TQ+ E +++V + LE + L E + ++ +K
Sbjct: 334 LQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKK 393
Query: 445 KVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRD 504
+ + ++ YE +L+ ++ + EEE L + K LE+L KH + I++V S+ +
Sbjct: 394 EASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAE 453
Query: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
+KKLQ ++E Q + + E++ QL++E K L KL + E+ L++ +++++
Sbjct: 454 RKKLQREVEAQLEEVRKKSEKEIKQLEEE----KAALNVKLQNSLLEVLRLEEFIQQNK- 508
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
+ E EL S+ ET+D L ++ E +++++ +AA
Sbjct: 509 ----------TRPTGAEESPQELGRQHCSILETQDPCLKLD-ETSPRGEEYQDKLAA--- 554
Query: 625 EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD 684
EE D+ + R ++ L+ D + + LL+ K + +
Sbjct: 555 EEGTSSDE------------------EERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEE 596
Query: 685 SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH 744
WQ + L Q+S ++Q LE S + LQ L+ ER++L +EL+E +Q+
Sbjct: 597 DWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMK 656
Query: 745 KSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQ 804
L+ +H A + +E+ + +E +A E L+++ S LQ HR ++ + QELQ
Sbjct: 657 AQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQ 716
Query: 805 TLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ--- 861
R ++ + +L SLR EL+ Q AA H ++L A + EL + R+Q
Sbjct: 717 EERERMQAQQALLLESLRQELSEQQAAC-----SGHQKDLEALQAELRA---LGRQQASS 768
Query: 862 -----SKEHICRITDL---------QEELRHREHHISELDKEVQHLHENISALTKELEFK 907
SK+HI + L +E L + + L E+E
Sbjct: 769 QCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQH 828
Query: 908 GKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINA 967
+E ++R Q R E+ + +E++ + +H +E M ADF+ L+ A
Sbjct: 829 QQEAQKLR----DQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLA 884
Query: 968 ALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETN 1027
AL+ L++ EK S+PED+Q+I L+ L ER+ IIK+L E+ +F+ + ++
Sbjct: 885 ALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSH 944
Query: 1028 FNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLD--PIP 1085
N+ F+ +P G + P K+KK D +R VSVPNL++ + +R++ PI
Sbjct: 945 RNRSFSFNPHPGYLTPSMKKKKVED--VPSRVVSVPNLASYAKNFLSGDLSSRINAPPIT 1002
Query: 1086 NSPVHDIE------FNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFT 1139
SP D + ++ + P + A+ SP QEWF +YF+
Sbjct: 1003 TSPSLDPSPSCGRTYKPNQSTDAKTATRTPDGETAQAKEVQQKQGSP---HQEWFTKYFS 1059
Query: 1140 F 1140
F
Sbjct: 1060 F 1060
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 176 bits (445), Expect = 1e-43
Identities = 236/1049 (22%), Positives = 455/1049 (43%), Gaps = 177/1049 (16%)
Query: 43 KMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE---------EIQQILAETREKILQ 93
++S+ +L +V L K+ + + Q L + EE EI+ + E + K L
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELT 1173
Query: 94 YKSKVTEELDLRRKIQVLES---SLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQ- 149
+ TE L+L +K+ S+ K+ ++ FE + + EA +Q
Sbjct: 1174 LEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233
Query: 150 ---------RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQE 200
+ ++E+RR EK Q EK E++ H E QE
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ-DLEKSHTKLQEEIPVLH--EEQE 1290
Query: 201 LLKSQQDHSASVNKGQEKAEELHRMEVESLNK---MLEELRLERKKLIEDYEGKLNKAQS 257
LL + ++ V++ QE EL + +S K L + +ER +L E ++ + +S
Sbjct: 1291 LLPNVKE----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKS 1346
Query: 258 F-------------YERELDTLKRSQLFTAESLQAS----------KEKEADLRKEFQGQ 294
E + D LK T +Q S KEK+ + K
Sbjct: 1347 LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM 1406
Query: 295 EAILRKTIGKLKTELQMV---------QDEAGSLL---DKCQKLQTALAIAENNVQVLQK 342
E K L+ E++M+ DE S+ D Q+LQ +VLQ
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ----------EVLQS 1456
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKD 402
+ D KE +++KH E E EL A L++Q + T V + +
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ--------------EETINELRVNLSE 1502
Query: 403 LESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ----QILELEKKVNEAKRTQQEYYE 458
E+E S + ++L + ++ L++K Q + E+++Q QI E+++KVNE K+ ++
Sbjct: 1503 KETEISTIQKQLEAINDK---LQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 459 RE--LKNLQSRLEEEVTQLNEAHSKTLEELAWKHHM-----AIEAVHSNAIRDKKKLQMD 511
++ L++++S++ E +L E+ + + K M A++ + K++
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619
Query: 512 LEEQHNKD----KLNLEEDKNQLQQELENLKEVLE-DKLNTANQEIGHLQ--DMVRKSEQ 564
++E K+ K+ + + E+E+LKE E KLN N E +++ ++ ++ +
Sbjct: 1620 MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1679
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELE---QERQQHEETIAA 621
+ S L+ +E L+ E D K++L+ET L + EL+ ++H+ETI
Sbjct: 1680 EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK 1739
Query: 622 MK---EEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDRE 678
++ E+ ++ M DLE + L+ + K++EELR+ H + LK+++
Sbjct: 1740 LRGIVSEKTNEISNMQKDLEHS-NDALKAQDLKIQEELRIAH-----------MHLKEQQ 1787
Query: 679 KNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEE 738
+ D + V + +++S ++++LE ++ Q +Q+L+A E Q +T L++
Sbjct: 1788 ETI--DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN---EHQLIT-----LKK 1837
Query: 739 QHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN-HLQQKHSAELQSLKDAHRESMEGFRI 797
+ K + E L Q ++ + +EN +L QK L+ +K +E R+
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRV 1897
Query: 798 EMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDI 857
E +TL+ E D+ K L QE A +E+++ +
Sbjct: 1898 E-----ETLKLE-RDQLKESL-----------------------QETKARDLEIQQELKT 1928
Query: 858 SRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE 917
+R SKEH + L+E++ + IS++ K++ + + +EL+ K ++LR++ +
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988
Query: 918 SN-QQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEM 976
N +++E + +L+K+ + A +L +++ +F T +L + + V+ E
Sbjct: 1989 VNMSHKKINEME---QLKKQFE---AQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD 2042
Query: 977 EEKYLMRESKPEDIQMITELKAMLTERDQ 1005
E + + K E Q I L+ M+ Q
Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQ 2071
Score = 149 bits (376), Expect = 1e-35
Identities = 217/1032 (21%), Positives = 447/1032 (43%), Gaps = 147/1032 (14%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKV 98
E+ + +S+K +++ + L ND+ ++ IQ + + E+ + ++E +EK+ + K
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 99 TEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR-------- 150
+Q +ES + + Q++ E + E+M+ EA ++R
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614
Query: 151 -IVTMSREVEEIRRKF---------EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQE 200
IV +E +E +F +EK+ L+ QFE K L LE+++ + R + +
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-LNLENIETENIR-LTQ 1672
Query: 201 LLKSQQDHSASVNKGQE---KAEELHRMEVESLNKMLEEL------RLERKKLI----ED 247
+L + SV K ++ EE ++E + L + L E + E K++ ++
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
Query: 248 YEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKT 307
++ ++K + + + + Q S A K ++ +++E LR LK
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE-------LRIAHMHLKE 1785
Query: 308 ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVE--SEL 365
+ + + G + +K KL EN+ LQ+++ + K E L++ K+V +
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845
Query: 366 AAARERLQQQASD--LVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER--LSQLEEER 421
+ E+L++Q D L L I L Q E +LE KS + ER L ++EE
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE----NLEEMKSVMKERDNLRRVEETL 1901
Query: 422 AFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
R + + +E K + LE+++++ A+ +E+ E + L+ ++ E+ Q+++
Sbjct: 1902 KLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE-TVDKLREKISEKTIQISD---- 1956
Query: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKD--KLNLEEDKNQLQQ---ELEN 536
+ + + K +LQ ++E K+ L ++ED N + E+E
Sbjct: 1957 ---------------IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001
Query: 537 LKEVLE-DKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLK 595
LK+ E L+ + + + Q + +K + L ++A +D R++ L + +D
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQ-LTKKLHESLEEIR-IVAKERDELRRIKESLKMERDQF- 2058
Query: 596 ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREE 655
+ + + ++RQ H+ +K E++L D H TE+LR++CS+++E
Sbjct: 2059 -----IATLREMIARDRQNHQ-----VKPEKRLLSDGQQH-----LTESLREKCSRIKEL 2103
Query: 656 LRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQ--- 712
L+ E D L L D EK +QK++ +K NL + Q++
Sbjct: 2104 LKRYSEMDDHYECLNRLSL-DLEKEI---EFQKELS------MRVKANLSLPYLQTKHIE 2153
Query: 713 ---TSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL 769
T+ Q+ +F + ++L L + + +++H+S+ + + E EK+KE
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID--EVEKQKELLIK 2211
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQH 829
HLQQ + L+D IE E+ L+D ++ S+++E
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMDLHIE---EI------LKDFSESEFPSIKTEFQQVL 2262
Query: 830 AAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE 889
+ ++ + +E + ++E+ + ++ + IC++ + + I + E
Sbjct: 2263 SNRKEMTQ--FLEEWLNTRFDIEK-LKNGIQKENDRICQVNNF------FNNRIIAIMNE 2313
Query: 890 VQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDV-MTADHLREK 948
E + ++KE E + L+ E N+++ + Q L L V T +
Sbjct: 2314 STEFEERSATISKEWE----QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP 2369
Query: 949 NIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQ--------MITELKAML 1000
++ T E ++E L+ SL E +E + +ESK +Q +I +L+A +
Sbjct: 2370 HVTSRATQLTTEKIRE----LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
Query: 1001 TERDQIIKKLIE 1012
E ++ ++K E
Sbjct: 2426 HESNKCLEKTKE 2437
Score = 145 bits (366), Expect = 2e-34
Identities = 222/1111 (19%), Positives = 459/1111 (41%), Gaps = 178/1111 (16%)
Query: 58 LNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLED 117
L T+ +E E ++ D E E + + +++ +Q +++ +L + +V LE+
Sbjct: 517 LRTEKEEMELKLKEKNDLDEFEALERKTK-KDQEMQLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 118 HIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRI-VTMSREVEEIRRKFEEKLRSFGQLQ 176
+ K + L E E +++ +Q ++Q ++ I + +S +E I + K F
Sbjct: 576 ELSSKVELLREKE---DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAET 632
Query: 177 VQFEKDKRLAL---EDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKM 233
V + + A E+L+ + +++EL + + + Q + E +M+V+ L K
Sbjct: 633 VALDAKRESAFLRSENLEL--KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD-LEKE 689
Query: 234 LEELRLERKKLIE--------------DYEGKLNKAQSFYERELDTLK--RSQLFTAESL 277
L+ E KL + EGK+ Q +E++ + R ++ L
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Query: 278 QASKEKEADLRKEFQGQEA---ILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 334
++ + LRKE Q + I+ KL +E+ + LL++ K + LA +
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ 809
Query: 335 NNVQVLQKQLDDAKEGEMALLSKHKEV----------------------------ESELA 366
+N + ++ + K M K+K V ++EL+
Sbjct: 810 SNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS 869
Query: 367 AARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-------LEE 419
+ LQ++ ++ + + + L+ ++ T++ +E EK+ + E+L Q L +
Sbjct: 870 YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 420 ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE---------YYERELKNLQSRLEE 470
E+ L+ +SL E+ Q ++ VN TQ++ ++ + L+S++ E
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
Query: 471 EVTQ---LNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE----QHNKDKLNL 523
EV++ + E +T +E K + I+ ++ + L D+++ + + +L
Sbjct: 990 EVSRNLHMEENTGETKDEFQQK-MVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL 1048
Query: 524 EEDKNQLQQELENL---KEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQ 580
++KN+LQQ LE++ KE L+ L + Q+ +R L + ++A ++
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 581 ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 640
+ + EL T D L E ++ L +L++++QQ M E +K +I
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK----------KIN 1158
Query: 641 WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLL 700
ENL+ E +EL L+H E ++ ++Q L E +
Sbjct: 1159 EIENLKNELK--NKELTLEHMETERLELAQKLNENYEEVKS------------------- 1197
Query: 701 KQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 760
+++ + L++LQ F ER L + E+E Q + LK AH+ + E
Sbjct: 1198 -------ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250
Query: 761 EKEKEQRALE--------NHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED 812
E + E L++ H+ + + H E ++ E Q ELE
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE- 1309
Query: 813 EGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKME-------------LERSIDISR 859
+L + + A I++ R +++ ++ E ++ ++++
Sbjct: 1310 ----LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 860 RQSKEHICR-ITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES 918
Q KEHI + +QE +E ++ +K+ +E +++ +FK K+ +R
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKD----NETTKIVSEMEQFKPKDSALLR--- 1418
Query: 919 NQQIRLHEQDLNKRLEKELDVMTA------DHLREKNIMRADFNKTNELLKEINAALQVS 972
I + L+KRL++ D M + D R + +++++ ++ E +KEI A
Sbjct: 1419 ---IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAK---H 1472
Query: 973 LEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIE------DNKFYQLELVN 1023
LE EE + E + I EL+ L+E++ I+K +E NK ++
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 1024 RETNFNKVFNSSPTVGVINPLAKQKKKNDKS 1054
+ N ++ V + + +K D +
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1563
Score = 54.7 bits (130), Expect = 5e-07
Identities = 100/526 (19%), Positives = 208/526 (39%), Gaps = 76/526 (14%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKV 98
E ++ K+++ K +L +H + E +I+ + + +L Y +K+
Sbjct: 2125 EKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY-VLSYVTKI 2183
Query: 99 TEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCA-EAQHVQRIVTMSRE 157
EE I E D ++ +++ L + + H +D + + E + ++ M
Sbjct: 2184 KEEQ--HESINKFEMDFIDEVEKQKELLIKIQ---HLQQDCDVPSRELRDLKLNQNMDLH 2238
Query: 158 VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQE 217
+EEI + F E F ++ +F++ ++R+E+ + L+ +
Sbjct: 2239 IEEILKDFSES--EFPSIKTEFQQ---------VLSNRKEMTQFLEEWLNT--------- 2278
Query: 218 KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYE-RELDTLKRSQLFTAES 276
R ++E L K I+ ++ + +F+ R + + S F S
Sbjct: 2279 ------RFDIEKL-----------KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERS 2321
Query: 277 LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALA--IAE 334
SKE E DL+ + E + K LKT L + D T+ A +
Sbjct: 2322 ATISKEWEQDLKSLKEKNEKLF-KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380
Query: 335 NNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQM 394
++ L+ L +AKE M SK +++ EL + +D++ K + +
Sbjct: 2381 EKIRELENSLHEAKESAMHKESKIIKMQKEL--------EVTNDIIAKLQ--AKVHESNK 2430
Query: 395 TQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQ 454
E T + ++ + +V +EE L+ K +D E+ + E EK+++ K T +
Sbjct: 2431 CLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVE 2490
Query: 455 EYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE 514
Y++E+ L L E + + +A ++ + H++ K L
Sbjct: 2491 --YQKEVIRL---LRENLRRSQQAQD-----------TSVISEHTDPQPSNKPLTCGGGS 2534
Query: 515 --QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDM 558
N L L+ + +L++E+ LK+ E + N+ + + Q +
Sbjct: 2535 GIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL 2580
Score = 33.5 bits (75), Expect = 1.2
Identities = 62/315 (19%), Positives = 124/315 (39%), Gaps = 23/315 (7%)
Query: 834 DLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHL 893
+ L + +E+ K +LE +R Q+ E ++ L EE + +E + + +
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKD-QLAQLLEEKDLLQKVQNEKIENLTRM 400
Query: 894 HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRA 953
S+LT + E K K R+ + ++ + + ++ T H N++R
Sbjct: 401 LVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLRE 460
Query: 954 D----------FNKTNELLKEI--NAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLT 1001
F+ T + L EI N A ++ +E E L D ++ + + + T
Sbjct: 461 IDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD-NLVLDYEQLRT 519
Query: 1002 ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVS 1061
E++++ KL E N + E + R+T ++ + + L K + ++ N S
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 1062 VPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEAS 1121
L + + + I + + +I+ + S L PK K L A++ A
Sbjct: 580 KVELLREKEDQI----KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 1122 PVASPDPQRQEWFAR 1136
D +R+ F R
Sbjct: 636 -----DAKRESAFLR 645
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 170 bits (430), Expect = 8e-42
Identities = 247/1070 (23%), Positives = 472/1070 (44%), Gaps = 148/1070 (13%)
Query: 37 SQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKS 96
++EM +++ K +L ++++ L ++ +E EEE QIL ++K+ +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEE------------EEERNQILQNEKKKMQAHIQ 953
Query: 97 KVTEELD----LRRKIQVLESSLEDHIKMKQQAL-------TEFEAYKHRVEDM------ 139
+ E+LD R+K+Q+ + + E IK ++ + ++F K +ED
Sbjct: 954 DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 140 QLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLA------LEDLQAA 193
QL E + + + + + E + EE+L+ + + + EK KR L+D A
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073
Query: 194 HRREIQEL----LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYE 249
+ +I EL K +++ ++ +G + E LH+ + K++ EL+ + +L ED+E
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDD--ETLHK---NNALKVVRELQAQIAELQEDFE 1128
Query: 250 G------KLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG 303
K K + EL+ LK T ++ A +E +E + L +
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 304 KLKTELQ-MVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKE--GEMALLSKHKE 360
+ ++Q M Q A +L + ++L+ A N + Q D KE E+ +L ++
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL---QQ 1245
Query: 361 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE- 419
V++E R++L Q +L K S L+ ++ ++ + L++E V+ L + E+
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRV-ELAEKAS--KLQNELDNVSTLLEEAEKK 1302
Query: 420 ------ERAFLRSK---TQSLDEEQKQQILELEKKVNEAK------RTQQEYYERELKNL 464
+ A L S+ TQ L +E+ +Q L L ++ + + + QQE E KNL
Sbjct: 1303 GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 465 QSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK-DKLNL 523
+ ++ +QL + K ++L ++E ++D + L LEE+ DKL
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIE--SLEEAKKKLLKDAEALSQRLEEKALAYDKL-- 1418
Query: 524 EEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERL 583
E+ KN+LQQEL++L L+ + A+ +L+ +K +Q L + + A + ++R
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVAS----NLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 584 QNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE--EEKLKVDKMAHDLEIKW 641
+ E + AL E+ +Q+++ A M++ K V K H+LE K
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE-KS 1533
Query: 642 TENLRQECSKLREELR-----LQHEEDKKSAMSQLLQLK----DREKNAARDSWQKKVED 692
L Q+ ++R +L LQ ED K + +Q +R+ + ++K
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL 1593
Query: 693 LLNQISLLKQNLEIQLSQS----------QTSLQQLQAQF---TQERQRLTQELEELEEQ 739
L+ Q+ L+ LE + Q + L+ L+AQ + R + ++L +L+ Q
Sbjct: 1594 LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 740 HQQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSAELQSLKDAHRESMEGFRI 797
+ + L+EA + + KE E++ +LE + Q EL S + A R + E R
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE-ELASSERARRHA-EQERD 1711
Query: 798 EMEQELQTL---RFELEDEGK---AMLASLRSELNHQHAAAIDLLRHNHHQ--------- 842
E+ E+ + L DE + A +A L EL + + ++LL +
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSN-MELLNDRFRKTTLQVDTLN 1770
Query: 843 -ELAAAKMELERSIDISR---RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENIS 898
ELAA + ++S + + RQ+KE ++ +L+ ++ S+ + L I
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK------SKFKATISALEAKIG 1824
Query: 899 ALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKT 958
L ++LE + KE R+ +N+ +R E+ L KE+ + D R + + K
Sbjct: 1825 QLEEQLEQEAKE----RAAANKLVRRTEKKL-----KEIFMQVEDERRHADQYKEQMEKA 1875
Query: 959 NELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
N +K++ L+ + EE R ++ TE L+ +K
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 155 bits (393), Expect = 2e-37
Identities = 225/962 (23%), Positives = 431/962 (44%), Gaps = 146/962 (15%)
Query: 79 EIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVE- 137
+++ +L TR++ + ++K E L ++ K +E LE+ + QQ L E +++
Sbjct: 840 KVKPLLQVTRQEE-ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 138 DMQLCAEAQHVQ-RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR 196
+ +L AEA+ ++ R+ +E+EEI E + V+ E+++ L++ + +
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESR--------VEEEEERNQILQNEKKKMQA 950
Query: 197 EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 256
IQ+L + +G + +L ++ E+ K +EE L L+ED K K +
Sbjct: 951 HIQDL-----EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL----LLEDQNSKFIKEK 1001
Query: 257 SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 316
E + + L +EK +L K QE ++ +LK E + Q+
Sbjct: 1002 KLMEDRIAEC-------SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE-- 1052
Query: 317 GSLLDKCQ-KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQ 375
L+K + KL ++ + LQ Q+D+ K + L K +E++ LA +
Sbjct: 1053 ---LEKAKRKLDGETTDLQDQIAELQAQIDELK---LQLAKKEEELQGALARGDD----- 1101
Query: 376 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ---LEEERAFLRSKTQ-SL 431
+ + K + + +++ Q +D ESEK+ N+ Q L EE L+++ + +L
Sbjct: 1102 --ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 432 DEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHH 491
D QQ L ++ E+E+ L+ LEEE H ++++ +H
Sbjct: 1160 DTTAAQQELRTKR-------------EQEVAELKKALEEETKN----HEAQIQDMRQRHA 1202
Query: 492 MAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQE 551
A+E + S + K+ + +LE K+K LE D +L E++ L++V + + +
Sbjct: 1203 TALEEL-SEQLEQAKRFKANLE----KNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 552 IGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQE 611
+Q++ K +G + L L + +LQNELD L+E + + +
Sbjct: 1258 DAQVQELHAKVSEG----DRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 671
Q ++T ++EE + K++ + +++ +N QE + EE R E+ + SQL
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 672 LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA------QFTQE 725
K KKV+D L I L++ + L ++ Q+L+ + +
Sbjct: 1374 ADTK------------KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 726 RQRLTQELEEL--EEQHQQRHKSLKEAHVLAF-QTMEEEKE------KEQRALENHLQQK 776
+ RL QEL++L + HQ++ S E F Q + EEK +E+ E ++K
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481
Query: 777 HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLL 836
+ L SL A E++E + E E++ + LR ++ED L S + ++
Sbjct: 1482 ETKAL-SLARALEEALEA-KEEFERQNKQLRADMED-----LMSSKDDVG---------- 1524
Query: 837 RHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHEN 896
N H EL +K LE+ ++ R Q +E L++EL+ E D +++ L N
Sbjct: 1525 -KNVH-ELEKSKRALEQQVEEMRTQLEE-------LEDELQATE------DAKLR-LEVN 1568
Query: 897 ISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFN 956
+ A+ + E L+ R E N++ ++ L + +EL+ D +++ + A
Sbjct: 1569 MQAMKAQFE----RDLQTRDEQNEE----KKRLLIKQVRELEAELEDERKQRALAVASKK 1620
Query: 957 KTNELLKEINAALQVSLEEMEE--KYLMR-ESKPEDIQMITELKAMLTERDQIIKKLIED 1013
K LK++ A ++ + + +E K L + +++ +D Q EL+ RD+I + E
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ--RELEEARASRDEIFAQSKES 1678
Query: 1014 NK 1015
K
Sbjct: 1679 EK 1680
Score = 95.9 bits (237), Expect = 2e-19
Identities = 130/675 (19%), Positives = 289/675 (42%), Gaps = 62/675 (9%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L +S +I QL + +L + +E E A + L + +Q LA+T++K+ +
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNL-EKQVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 102 LDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDM--QLCAEAQHVQRIVTMSREVE 159
+ ++K+ +L ++ K A + E K+R++ L + H +++ + +E
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS---NLE 1447
Query: 160 EIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR------REIQELLKSQQDHSASVN 213
+ ++KF++ L + ++ +++ A + + R ++E L+++++
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 214 KGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFT 273
+ + E+L + + + K + EL ++ L + E + + E EL + ++L
Sbjct: 1508 QLRADMEDLMSSK-DDVGKNVHELEKSKRALEQQVEEMRTQLEEL-EDELQATEDAKLRL 1565
Query: 274 AESLQASKEK-EADLR---KEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTA 329
++QA K + E DL+ ++ + ++ +L K + +L+ EL+ + + + +K++
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 330 LAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 389
L E ++ K D+ + L ++ K+ + EL AR + +
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE--------------I 1671
Query: 390 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA 449
A E +K LE+E ++ E L+ E R + L +E ++E
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 450 KRTQQEYYERELKNLQSRLEEEVTQ---LNEAHSKTLEELAWKHHMAIEAVHSNAIRDKK 506
+R E + L+ LEEE + LN+ KT ++ + A A +A +
Sbjct: 1732 RRL-----EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN--AELAAERSAAQKSD 1784
Query: 507 KLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 566
+ LE Q+ + K L+E + ++ + + LE K IG L++ + + +
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK-------IGQLEEQLEQEAKER 1837
Query: 567 GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE 626
+A L+ + + + +++ + + K+ + ++Q ++Q EE EEE
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEA-----EEE 1892
Query: 627 KLKVD----KMAHDLE--IKWTENLRQECSKLREELRLQHEEDKKSAMS--QLLQLKDRE 678
+ + K+ +L+ + E L +E S L+ LR S+ S + L L+
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGAS 1952
Query: 679 KNAARDSWQKKVEDL 693
+ D + K D+
Sbjct: 1953 LELSDDDTESKTSDV 1967
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 167 bits (422), Expect = 7e-41
Identities = 229/1009 (22%), Positives = 423/1009 (41%), Gaps = 135/1009 (13%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQ---------ALKDAHEEEIQQILAETRE 89
E + ++KI+ T + AL K E + A +H EI+Q LA R+
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
Query: 90 KILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQ 149
Q+ L+L K+ L + +E + K + L + E K +VED+Q E + +
Sbjct: 398 GHDQHV------LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 451
Query: 150 R----IVTMSRE--VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK 203
+ + T+S + + E+ + +++ +L+ + E +K D+ + +EI L +
Sbjct: 452 KGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 511
Query: 204 ----SQQDHSASVNKGQE---KAEELHRMEV--------------ESLNKMLEELRLERK 242
++ DH + +E EE H+ E+ ESL LE E
Sbjct: 512 KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 243 KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTI 302
+I ++ KL A + +++ ++ LK S ++ L + A+L+ + + + I
Sbjct: 572 DVIALWKSKLETAIASHQQAMEELKVS---FSKGLGTETAEFAELKTQIEKMRLDYQHEI 628
Query: 303 GKLKTELQMVQDEAGSLLDKCQ-KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEV 361
L+ + + ++ + KL + EN+++ ++ +LD A++ + E+
Sbjct: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV------EM 682
Query: 362 ESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE--- 418
E L +LQ+ +K + +LQA Q I + S+ E+L L+
Sbjct: 683 EDTL----NKLQEAE----IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 734
Query: 419 ----EERAFLRSKTQSLDEEQKQ-QILELEKKVNEAKRTQ--QEYYERELK--NLQSRLE 469
E ++ ++ Q L+ +KQ + LE+EK +K + +E RELK NLQ L
Sbjct: 735 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL- 793
Query: 470 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 529
EV+Q+ E K L+ L K A E A+ ++ +Q + + H K EE N
Sbjct: 794 SEVSQVKETLEKELQILKEKFAEASE----EAVSVQRSMQETVNKLHQK-----EEQFNM 844
Query: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL-----------GSAEGLIASLQD 578
L +LE L+E L D + +E ++ + K+++ L G + + D
Sbjct: 845 LSSDLEKLRENLAD-MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903
Query: 579 S---QERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAH 635
+ER EL L E L ++ + +Q ++ A EEEK ++++
Sbjct: 904 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963
Query: 636 DLEIKWTENLRQECSKLR-------EELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 688
DLE K E +C +L+ E + +HEE ++ LL +D+ K A ++
Sbjct: 964 DLE-KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN--- 1019
Query: 689 KVEDLLNQI-SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 747
LL ++ L KQ + + +Q+ Q+ Q T+E+ LE+ ++ + + L
Sbjct: 1020 --SGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1077
Query: 748 KEAHVLAFQTMEE-EKEKEQRALENHLQQKHSAELQSLKDAHRE------SMEGFRIEME 800
+ +EE K KE +EN ++ E+++LK A + +++ +++
Sbjct: 1078 DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA 1137
Query: 801 QELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRR 860
+EL R E+ K L RS LN+Q + ++ K L++SI I+
Sbjct: 1138 EELGRSRDEVTSHQK--LEEERSVLNNQ-LLEMKKRESKFIKDADEEKASLQKSISITSA 1194
Query: 861 QSKEHICRITDLQEE---LRHREHHISELDKEVQHLHEN---ISALTKELEFKGKEILRI 914
E + L+ E LR L VQ L + + K LE + KE R
Sbjct: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254
Query: 915 RSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLK 963
S S+ + + E ++D + N + D + N+ LK
Sbjct: 1255 LSSSSGNTDTQADEDERAQESQIDFL--------NSVIVDLQRKNQDLK 1295
Score = 139 bits (350), Expect = 2e-32
Identities = 175/854 (20%), Positives = 388/854 (45%), Gaps = 100/854 (11%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKD-------AHEEEIQQILAETREKI 91
+M L + ++I+ L + + T +H+ I +LK+ H++EI+ + T EK+
Sbjct: 497 DMSLSLLQEISSLQEKLEVTRT---DHQREITSLKEHFGAREETHQKEIKALYTAT-EKL 552
Query: 92 LQYKSKVTEELDLRRK-----IQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQ 146
+ + +L+ K I + +S LE I QQA+ E + + + A+
Sbjct: 553 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 612
Query: 147 HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQ 206
+ ++E++R ++ ++ + LQ Q + ++ ++++A R ++ +++K ++
Sbjct: 613 -------LKTQIEKMRLDYQHEIEN---LQNQQDSERAAHAKEMEAL-RAKLMKVIKEKE 661
Query: 207 DHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTL 266
+ ++ +KAE+ H +E+E L+E ++ K+L E + K N+ + L
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQL 720
Query: 267 KRSQ--LFTAESLQ-ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC 323
K ++ L ++L+ AS E +++++K Q EA K I L+ E +A S+ +
Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLEIEKNAESSKASSITREL 779
Query: 324 QKLQTALAIAENNVQVLQKQLDDAKEGEMALLS-KHKEVESELAAARERLQQQASDLVLK 382
Q + L + N+ + Q+ + E E+ +L K E E + + +Q+ + L K
Sbjct: 780 QGRELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838
Query: 383 ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILEL 442
ML + + D+E++ +ER QL + + L + + + +L
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 898
Query: 443 EKKVNEAKRTQQEYYERELKNLQ-----SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAV 497
K +E + +++ E +LK + S L++ + + ++ +E A KH E
Sbjct: 899 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEE 954
Query: 498 HSNAIRDKKKLQMDLEEQHN-------KDKLNLEEDKNQLQQELENLKEVL---EDKLNT 547
R L+ +E HN + + E K + ++ L+NL++ L EDKL
Sbjct: 955 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
Query: 548 ANQEIGHL--------------------QDMVRKSEQGLGSAEGLIASLQDSQE---RLQ 584
A +E L +D ++ EQ +ASL+D+++ +LQ
Sbjct: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074
Query: 585 NELD-LTKDSLKETKD-----ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 638
NELD L +++LK ++ LL VE + +E ++ ET+ ++ ++ + +
Sbjct: 1075 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-N 1133
Query: 639 IKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQIS 698
+K E L + ++ +L EE++ +QLL++K RE +D+ ++K L IS
Sbjct: 1134 VKLAEELGRSRDEVTSHQKL--EEERSVLNNQLLEMKKRESKFIKDADEEKA-SLQKSIS 1190
Query: 699 -----LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVL 753
L +++ E++ +++ ++ + + + + Q LE + + + + K+L+
Sbjct: 1191 ITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLE----- 1245
Query: 754 AFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDE 813
++ ++ K Q + + + E + +++ + + ++++++ Q L+ ++E
Sbjct: 1246 ----LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1301
Query: 814 GKAMLASLRSELNH 827
+A L +LN+
Sbjct: 1302 SEAALNGNGDDLNN 1315
Score = 127 bits (319), Expect = 6e-29
Identities = 172/755 (22%), Positives = 320/755 (42%), Gaps = 107/755 (14%)
Query: 326 LQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK-EVESELAAARERLQQQASDLVLKAS 384
LQ AL + +++ L + D + E+A + H E+E ELA AR+ Q +L K
Sbjct: 353 LQEALKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411
Query: 385 HIG-MLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELE 443
+ M++A + + LE EK +V + ++EEE + + + +K +I+ELE
Sbjct: 412 QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE-SITKGDLEVATVSEKSRIMELE 470
Query: 444 K-------KVNEAKRTQQEYYE-----------RELKNLQSRLE-------EEVTQLNEA 478
K +V E +R + +E+ +LQ +LE E+T L E
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE- 529
Query: 479 HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE--QHNKDKLNLEEDKNQL-----Q 531
H EE K A+ ++ + L+ LE + N D + L + K + Q
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 589
Query: 532 QELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ-NELDLT 590
Q +E LK L T E L+ + K + + QDS+ E++
Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649
Query: 591 KDSL----KETKDALLNVEGELEQERQQH----EETIAAMKEEEKLKVDKMAHDLEIKWT 642
+ L KE +++L + +L++ QH E+T+ ++E E +++K
Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE----------IKVKEL 699
Query: 643 ENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD-REKNAARDSWQKKVEDLLNQISLLK 701
E L+ +C++ + + K+ +LL L R+ ++ S KK+ L
Sbjct: 700 EVLQAKCNEQTKVID-NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758
Query: 702 QNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA--FQTME 759
++LEI+ + + + + +LT E L E Q + KE +L F
Sbjct: 759 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
Query: 760 EEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLA 819
EE QR+++ + + H E E F + + +L+ LR L D M A
Sbjct: 819 EEAVSVQRSMQETVNKLHQKE------------EQFNM-LSSDLEKLRENLAD----MEA 861
Query: 820 SLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
R + ++L AK +LE I + S ++ ++T + +ELR +
Sbjct: 862 KFRE-------------KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
Query: 880 EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQ--IRLHEQDLNKRLEKEL 937
E + EL ++ +EN S L K + E + +++E +QQ + HE++ K LE++L
Sbjct: 909 ERDVEELQLKLTKANENASFLQKSI-----EDMTVKAEQSQQEAAKKHEEE-KKELERKL 962
Query: 938 D----VMTADHLREKNIMRADFNKTNELL---KEINAALQVSLEEMEEKYLMRESKPEDI 990
M H + + + T+E +EI LQ +L + E+K ++ ++ E+
Sbjct: 963 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK--LKGAREENS 1020
Query: 991 QMITELKAMLTERDQIIKKLIEDNKFYQLELVNRE 1025
++ EL+ + + D+ ++ +E + +E
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 160 bits (406), Expect = 5e-39
Identities = 232/1027 (22%), Positives = 445/1027 (43%), Gaps = 161/1027 (15%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVL 111
TKV L E E A EEE L + REK L ++++TE L+ ++
Sbjct: 832 TKVKPLLQVSRQEEEMM------AKEEE----LVKVREKQLAAENRLTEMETLQSQLMAE 881
Query: 112 ESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQ-RIVTMSREVEEIRRKFEEKLR 170
+ L++ + QA TE LCAEA+ ++ R+ +E+EEI E +
Sbjct: 882 KLQLQEQL----QAETE------------LCAEAEELRARLTAKKQELEEICHDLEAR-- 923
Query: 171 SFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESL 230
V+ E+++ L+ + ++ IQEL + ++ ++ K Q L ++ E+
Sbjct: 924 ------VEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ-----LEKVTTEAK 972
Query: 231 NKMLEELRLERKKLIEDYEGKLNKAQSFYE---RELDTLKRSQLFTAESLQASKEK---- 283
K LEE ++ ++ED KL K + E E T + ++SL K K
Sbjct: 973 LKKLEEEQI----ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 284 ----EADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQV 339
E LR+E + Q L KT KL+ + + D+ L + +L+ LA E +Q
Sbjct: 1029 ITDLEERLRRE-EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 340 LQKQLDDAKEGEMALLSKHKEVESELA----------AARERLQQQASDL-----VLKAS 384
++++ + L K +E+ES+++ A+R + ++Q DL LK
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 385 HIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEK 444
L +T QE+ K + VN LEEE ++ Q + ++ Q + EL +
Sbjct: 1148 LEDTLDSTAAQQELRSK----REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 445 KVNEAKRTQQ--EYYERELKNLQSRLEEEVTQLNEAHSKT----------LEELAWKHHM 492
++ + KR + E ++ L+N + L EV L + + L+EL K +
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 493 AIEAVHSNAIRDKKKLQMDLEE------QHNKDKLNLEEDKNQLQQELENLKEVLED--- 543
E V + KLQ++L+ Q + L +D + L+ +L++ +E+L++
Sbjct: 1264 G-ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 544 -------KLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKE 596
KL E ++ + + E+ + E IA+L ++ +++ + L+
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 597 TKDALLNVEGELEQERQQHEETIAAMKEEEKLK--VDKMAHDLEIKWTENLRQECSKLRE 654
++ ++ +LE Q+HEE +AA + EK K + + DL + + C+ ++
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 655 ELRL-QHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQT 713
+ + Q ++K+ ++ + +DR + AR+ K + L + LE + Q +
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS--------LARALEEAMEQ-KA 1493
Query: 714 SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLK--EAHVLAFQTMEEEKEKEQRALEN 771
L++L QF E + L +++ + + KS + E V +T EE E E +A E+
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 772 HLQQKHSAELQSLKDAHRESMEGFRIEMEQ-------ELQTLRFELEDEGK--AMLASLR 822
+ + LQ++K ++G + E+ +++ + ELEDE K +M + R
Sbjct: 1554 -AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 823 SELN---HQHAAAIDLLRHNHHQ------ELAAAKMELERSIDISRRQSKEHICRITDLQ 873
+L A ID N + +L A + R +D +R +E + + + +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 874 EELRHREHHISELDKEV--------QHLHENISALTKELEFKGKEILRIRSESNQQIRLH 925
++L+ E + +L +E+ Q E + GK L + + + R+
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 926 EQD------------LNKRLEK---ELDVMTADHLREKNIMRADFNKTNELLKEINAALQ 970
+ + +N RL+K ++D + D E++ + + N +L ++ N L+
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ-NKELK 1791
Query: 971 VSLEEME 977
V L+EME
Sbjct: 1792 VKLQEME 1798
Score = 121 bits (304), Expect = 3e-27
Identities = 204/959 (21%), Positives = 381/959 (39%), Gaps = 194/959 (20%)
Query: 38 QEMHLKMSKKIAQLTKVIYALN-TKNDEHESAIQALKDAHEEEIQQILAETREKILQYKS 96
Q L KK+ + + N T+ +E ++ LK+ HE I + E+ L+ +
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL-----EERLRREE 1040
Query: 97 KVTEELD-LRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCA------EAQHVQ 149
K +EL+ RRK++ + L D I Q + E + + E+ A EA
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 150 RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHS 209
+ RE+E + +E L S + + EK KR E+L+A LK++ + +
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA---------LKTELEDT 1151
Query: 210 ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
Q++ EV L K LEE + I++ K ++A +L+ KR
Sbjct: 1152 LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 270 QLFTAESLQASKEKEADLRKEFQ------GQEAILRKTIGKLKTELQMVQDEAG----SL 319
+ ++ Q + + +L E + G RK + ELQ+ +E L
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 320 LDKCQKLQTAL---------------------AIAENNVQVLQKQLDDAKEGEMALLSKH 358
DK KLQ L + E+ +Q Q+ L + +++L +K
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 359 KEVESELAAARERLQQ-----------------QASDLVLKASH-IGMLQATQMTQEVTI 400
K+VE E + RE+L++ Q +D+ K +G L+ + +
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 401 KDLESEKSRVNERLSQLEEERAFLRSKTQSLDE------EQKQQILELEKK--------- 445
KDLE R E+++ ++ Q LD+ Q+Q LEKK
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 446 ---------VNEAKRTQQEYYERELK--NLQSRLEE------EVTQLNEAHSKTLEELAW 488
E R + E E+E K +L LEE E+ +LN+ +E+L
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNK-----DKLNLEED------------KNQLQ 531
++VH + K+ L+ +EE + D+L ED K Q +
Sbjct: 1512 SKDDVGKSVHELE-KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 532 QELENLKEVLEDKLNTANQEI----GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 587
++L+ E E+K +++ L+D ++ + + + L L+D + + +
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSAN 1630
Query: 588 DLTKDSLKETKDALLNVEG---ELEQERQQHEETIAAMKEEEKLKVDKMAHDL-----EI 639
+++K+ + ++ EL+ R EE +A KE EK K+ M ++ E+
Sbjct: 1631 KNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK-KLKSMEAEMIQLQEEL 1689
Query: 640 KWTENLRQECSKLREEL--------------------------RLQHEEDKKSAMSQLLQ 673
E +++ + R+EL +L+ E +++ ++L+
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 674 LKDREKNAARD----------SWQKKVEDLLNQISLLKQNLEIQL--------SQSQTSL 715
+ ++ N D S +K E+ Q+ + L+++L S+ + S+
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 716 QQLQAQFTQERQRLTQELEELE---EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENH 772
L+A+ Q ++L E +E + +Q ++ K LK+ + Q +E + EQ
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD---VLLQVDDERRNAEQ---YKD 1863
Query: 773 LQQKHSAELQSLKDAHRESME------GFRIEMEQELQTLRFELEDEGKAMLASLRSEL 825
K S L+ LK E+ E R ++++EL+ E D ++SL+++L
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNREVSSLKNKL 1921
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 159 bits (403), Expect = 1e-38
Identities = 256/1177 (21%), Positives = 498/1177 (42%), Gaps = 241/1177 (20%)
Query: 38 QEMHLKMSKKIAQ--------LTKVIYALNTKNDEHESAIQALKDAH------------- 76
QE LK K+ Q LT AL + DE ++ +KD H
Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350
Query: 77 --------EEEIQQILAETREKILQYKSKVTEEL-DLRRKIQVL----ESSLEDHIKMKQ 123
E++ ++AET+ ++ + EE+ LR +I+ + E E K ++
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410
Query: 124 QALTEFE---AYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQ-F 179
A E E + + E+ + +A+ ++I T+ + EE R +++L Q V
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470
Query: 180 EKDKRLALEDLQAAHRREI----QELLKS--------QQDHSASVNKGQEKAEELHRMEV 227
+K + LQ H +E+ QEL K Q+ ++ K Q + ++ + +
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKE 530
Query: 228 ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADL 287
+ + LEEL L++K ++ + E KL Q E + + +SLQ +K + DL
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
Query: 288 RKEFQGQEAILRKTI----GKLKTEL-------------------QMVQDEAGSLLDKCQ 324
+ ++ K I K KTEL Q Q E L +KC+
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 325 KLQTALA----------IAENNVQVLQKQLDDAKEGEMALLS---------KHKEVESEL 365
+ + L I E N + L+K D K+ E+ LS +HK +E EL
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKL--DVKQTELESLSSELSEVLKARHK-LEEEL 707
Query: 366 AAARERLQQQASDLVLKAS-----HIGMLQATQMTQEVTIKDLESE-KSRVN-------E 412
+ +++ + +L K H + + EV+I+ E K ++N E
Sbjct: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
Query: 413 RLSQLEEERAFLRS-----KTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSR 467
R L+E +A + + K + +Q L++ + A Q + YE +L LQ +
Sbjct: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM-DLEEQHNKDKLNLEED 526
L + T+ + E A K + E D K+Q+ DL +Q LE+
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTEL-------DAHKIQVQDLMQQ-------LEKQ 873
Query: 527 KNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER---- 582
++++Q++++L +V E KL N+E +++Q L E +I +++ Q++
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNKE-------QEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 583 LQNELDLTKDSL----KETKDALLNVEGELEQERQQHEETIAAMKE---EEKLKVDKMAH 635
L +L +DS+ +E + N E ++E+ +Q+ +E +K+ +++ K+ K
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 636 DLEIKWTENLRQECSKLREELRLQH----------EEDKKSAMSQLLQLKDREKNAARDS 685
+ ++ ++ +Q +K+ E + E ++K + L ++ RE N
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI 1046
Query: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQ---FTQERQRLTQE---------- 732
W+KK L Q L++ EIQL + + + +L+ + F E++ + +E
Sbjct: 1047 WEKK---LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
Query: 733 ----LEELEEQHQQR-------------------------HKSLKEAHVLAFQTME---- 759
L EL+EQ +Q+ +KSLKE L Q +E
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163
Query: 760 -EEKEKEQRALENHLQQKHSAELQSLKDAH---RESMEGFRIEMEQELQTLRFELE---D 812
EE +++ L + L+ E QSLK +H +S+E +E ++ + L +L+
Sbjct: 1164 AEEDKRKVSELTSKLKTT-DEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
Query: 813 EGKAMLASLRSEL----NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICR 868
+ +A+L + +EL + + A + + H H+ + L ++ +S +++ + +
Sbjct: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ--LRQ 1280
Query: 869 ITDLQEEL----RHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRL 924
+T+ Q L + H + E + +++ + +I +L E KE L+ + QQ
Sbjct: 1281 LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE-----KEALQKEGGNQQQAAS 1335
Query: 925 HEQDLNKRLEKELD------VMTADHLREKNIMRADFNKTNELLKEINAALQ--VSLEEM 976
++ +L+KEL + + L+EK + + + ++ L ++N LQ +SL E
Sbjct: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKV---EISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 977 EE--KYLMRESKPEDIQMITELKAMLTERDQIIKKLI 1011
E L ++ E +++ +++ + + D + K+ I
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Score = 147 bits (371), Expect = 6e-35
Identities = 204/988 (20%), Positives = 445/988 (45%), Gaps = 134/988 (13%)
Query: 65 HESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQ 124
++SA A+EE+ LA+ ++K+L + TE + L +++ +E+ K+
Sbjct: 806 YQSATHEQTKAYEEQ----LAQLQQKLLDLE---TERILLTKQVAEVEAQ-------KKD 851
Query: 125 ALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK--- 181
TE +A+K +V+D+ E Q+ + M ++V+ + + +E KL + Q Q ++
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSE----MEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907
Query: 182 DKRLALEDLQAAHRREIQEL---LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+K + ++ ++EI+ L L +++D +N+ E + ++E + + +E++
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAIL 298
KK + D E KL K E E L+ S Q K+ A + + Q A +
Sbjct: 968 ETLKKKLLDQEAKLKK-----ELENTALELS--------QKEKQFNAKMLEMAQANSAGI 1014
Query: 299 RKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKH 358
+ +L+T Q Q E+ + + + ++L ++I E + ++L + E ++
Sbjct: 1015 SDAVSRLETN-QKEQIESLTEVHR-RELNDVISIWEKKLNQQAEELQEIHEIQL------ 1066
Query: 359 KEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE 418
+E E E+A ++++ + I L+ + Q+ T+ +L+ + + + ++ L
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 419 EERAFLRSKTQSLDEEQKQQILE---LEKKVNEAKRTQQEYYERELKNLQSRL---EEEV 472
++ L++ + L+ + + + E L++++ E K +E +R++ L S+L +EE
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE-DKRKVSELTSKLKTTDEEF 1185
Query: 473 TQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ 532
L +H K+ + L K ++ + ++ +Q+D + ++ + L+
Sbjct: 1186 QSLKSSHEKSNKSLEDK------SLEFKKLSEELAIQLD---------ICCKKTEALLEA 1230
Query: 533 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 592
+ L + K N I H Q K ++ L ++ L+ +L E +
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 593 SLKETKDALLNVEGELEQERQQHEETIAAMKEE-EKLKVDKMAHDLEIKWTENLRQECSK 651
S ++ L ++ E I +MK + E L +K A E +Q+ +
Sbjct: 1291 SFQQATHQL-----------EEKENQIKSMKADIESLVTEKEALQKE----GGNQQQAAS 1335
Query: 652 LREELRLQHEEDKKSAMSQLLQLKD--REKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 709
+E Q +++ ++ + +K+ +EK S K++ DL Q+ QN I LS
Sbjct: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL----QN-SISLS 1390
Query: 710 QSQTSLQQLQAQFTQERQRLTQELEEL----EEQHQQRHKSLKEAHVLAFQTMEEEKEKE 765
+ + ++ L+ Q+ +E+ L ++++L + +++ +L++ + + E +K+ +
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 766 QRALENHLQQKH---SAELQSLKDAHRESMEGFRIEMEQELQTLRF-----ELEDEGKAM 817
R ++ K EL+S K+A+ + + ++ E + Q RF E+ED+ M
Sbjct: 1451 SRFTQHQNTVKELQIQLELKS-KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 818 ---LASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQE 874
++L +EL Q A ++L H + +E+E ++ + +++ +L +
Sbjct: 1510 EKKESNLETELKSQTARIMELEDH-----ITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 875 ELRH-------REHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQ 927
+L+H +++ + E ++++ L + ++ ELE K KE+ + N ++ E+
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHV----NLSVKSKEE 1620
Query: 928 DLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+L K LE L+ +A L E K + + I L +EE EE+Y K
Sbjct: 1621 EL-KALEDRLESESAAKLAELK------RKAEQKIAAIKKQLLSQMEEKEEQY-----KK 1668
Query: 988 EDIQMITELKAMLTERDQIIKKLIEDNK 1015
++EL L ER++ + L E K
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLK 1696
Score = 135 bits (341), Expect = 2e-31
Identities = 244/1177 (20%), Positives = 498/1177 (42%), Gaps = 198/1177 (16%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAET 87
+L+ ++ +M A ++ + L T E I++L + H E+ +++
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ---IESLTEVHRRELNDVISIW 1047
Query: 88 REKI------------LQYKSKVTEELDLRRKIQVLESSLEDHIK----MKQQALTEFEA 131
+K+ +Q + K E +L++KI + E+ K +K++ + +
Sbjct: 1048 EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 132 YKHRVEDMQLCAEAQHVQRIVT----MSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLAL 187
E QL ++ HV + + +E++ + L+ LQ Q + K LA
Sbjct: 1108 LNELQE--QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
Query: 188 EDLQAAHRREIQEL---LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKL 244
ED +R++ EL LK+ + S+ EK+ NK LE+ LE KKL
Sbjct: 1166 ED-----KRKVSELTSKLKTTDEEFQSLKSSHEKS-----------NKSLEDKSLEFKKL 1209
Query: 245 IEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS---KEKEADLRKEFQGQEAILRKT 301
E+ +L+ E L+ K ++L S + + + + +EA+L KT
Sbjct: 1210 SEELAIQLDICCKKTEALLEA-KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 302 --IGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
+ +L+ +L+ + +E +L Q+ L EN ++ ++ ++ + AL K
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QK 1325
Query: 360 EVESELAAARER---LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ 416
E ++ AA E+ + Q +L + + +++ ++V I L + + +N +L
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 417 ---LEEERAFLRSKTQSLDEEQ------------------KQQILELEK------KVNEA 449
L E+ A + S + DEE+ K++I LE+ K +E
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 450 KRTQQEYY---ERELKNLQSRLE---EEVTQLNEAHSKTLEELAWKHHM------AIEAV 497
K+ Q + + +K LQ +LE +E + +E + EEL ++ +E
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 498 HSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTAN-------Q 550
S + + L+ +L+ Q + + LE+ Q E+E+L EVL++ + Q
Sbjct: 1506 KSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 551 EIGHLQDM-------VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLN 603
++ H Q++ V+++E+ + + E + S++ E + EL+ S+K ++ L
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624
Query: 604 VEGELEQE--------RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREE 655
+E LE E +++ E+ IAA+K++ ++++ + +L + +KL+E
Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684
Query: 656 LRLQHEEDKK-----SAMSQLLQLKDREKNAARDSWQKKVED-------LLNQISLLKQN 703
R H ++K S+ S+ L + KN A + Q++ + +IS+L++N
Sbjct: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 704 LEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKE 763
L T ++L + QE++ E+ Q+Q+R L+ A E K+
Sbjct: 1745 L--------TEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA---------EAKQ 1787
Query: 764 KEQRALENHLQQK--HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLAS- 820
E +++ HLQ++ + SL A EG + ++ + Q L +D K +
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKE 1846
Query: 821 LRSELNHQHAAAID--LLRHN--HHQELAAAKMELERSIDISRRQSKEHICRITDLQEEL 876
L ++ Q +D L+R H E+ + E+ + + + + + E
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 877 RHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ + H + L N+ A +LEFK R + + ++I RL+K+
Sbjct: 1907 KSKSHLVQP------KLLSNMEAQHNDLEFKLAGAEREKQKLGKEI--------VRLQKD 1952
Query: 937 LDVMTADHLREKNIMRADFNKTNE--------------------LLKEINAALQVSLEEM 976
L ++ +H +E I++ ++++ E L++E N L +E+
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Query: 977 EEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDN-------KFYQLELVNRETNFN 1029
E +K ++++ L++ E +Q++KK+ E + K Y+ L RE
Sbjct: 2013 EMTIKETINKAQEVE-AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMT 2071
Query: 1030 -KVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNL 1065
KV + + + +QK + +++P N V++ L
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
Score = 131 bits (329), Expect = 4e-30
Identities = 210/976 (21%), Positives = 421/976 (43%), Gaps = 167/976 (17%)
Query: 170 RSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVES 229
R G Q F + +L + +++ R I+E L + V E L+R++++S
Sbjct: 53 RESGDTQ-SFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR--ESLNRLDLDS 109
Query: 230 LNKMLE---ELRLERKKLIEDYEGKLNKAQSFY-----ERELDTL--KRSQLFTA-ESLQ 278
+ ++ E + L+ + + LNK Q ER L + K S+L TA + LQ
Sbjct: 110 STASFDPPSDMDSEAEDLVGNSDS-LNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168
Query: 279 ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK----CQKLQTALAIAE 334
K+K + Q Q+ LR+ I +L+ ELQM Q L ++ ++ +++ +
Sbjct: 169 REKKKLQGILS--QSQDKSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225
Query: 335 NNVQVLQKQLDDAKEGEMALLSKHK-EVESELAAARERLQQQASDLVLKASHIGMLQATQ 393
V +L+++L + L + E ++E+ E + +V + + L+ Q
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285
Query: 394 MTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEK--KVNEAKR 451
+K E+ R E + +E+ L S+ ++L E+ +++ ELEK ++ A++
Sbjct: 286 QR----VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341
Query: 452 TQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD 511
T+ R+ KNL +LE++ + I + K+ +
Sbjct: 342 TKLITQLRDAKNLIEQLEQDKGMV--------------------------IAETKRQMHE 375
Query: 512 LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
E ++ L Q+ + E L+E E A +E+ E+ L +A+
Sbjct: 376 TLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL----------EKALSTAQ- 424
Query: 572 LIASLQDSQERLQNELDLTKDSLKET-KDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
++++ +L+ E+D ++++T ++ ++++ EL + +Q+ + + EE+ K+
Sbjct: 425 ---KTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 631 DKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKV 690
K+ H+ E+ E QE +K + + +E K A+ + ++ + K
Sbjct: 482 QKL-HEKELARKE---QELTKKLQTREREFQEQMKVALEK-----------SQSEYLKIS 526
Query: 691 EDLLNQISLLKQNLEIQ----LSQSQTSLQQLQAQFTQERQR---LTQELEELEEQHQQR 743
++ Q SL + LE+Q L++S+ L+ LQ + R R L LE+ ++++ +
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 744 HKSL-------KEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFR 796
K L K H M E+ + E +L++ + +LQ LK ++ ME R
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 797 IEMEQELQTLRFELE------------------DEGKAMLASLRSELN------------ 826
+ EQE +TL + E D + L SL SEL+
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 827 ------------HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQE 874
+ A +D +++H Q++ + E E SI + + K+ +I L+
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD---QINQLEL 763
Query: 875 ELRHREHHISELDKEVQHLHENISALTKELEFKGKEI---LRIRSESNQQIRLHEQDLNK 931
L+ R+ H+ E V++L +I EL+ ++ +S +++Q + +E+ L +
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 932 RLEKELDVMTADHLREKNIMRADFNKTN---EL------LKEINAALQVSLEEMEEKY-- 980
+K LD+ T L K + + K + EL ++++ L+ EME+K
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 981 --LMRESKPEDIQMITE-LKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPT 1037
+ ESK ED E K +L E++ +I ++ E K ++E++ + K+ +
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK-KEIEILTQ-----KLSAKEDS 937
Query: 1038 VGVINPLAKQKKKNDK 1053
+ ++N + K KN +
Sbjct: 938 IHILNEEYETKFKNQE 953
Score = 119 bits (298), Expect = 2e-26
Identities = 188/934 (20%), Positives = 389/934 (41%), Gaps = 110/934 (11%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKN-------DEHESAIQALKDAHEEEI 80
Q A H ++ + M I L AL + E ES I LK E I
Sbjct: 1293 QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENI 1352
Query: 81 QQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQ 140
+ E K K E L +++ L L++ I + ++ K E+
Sbjct: 1353 NAVTLMKEE----LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-- 1406
Query: 141 LCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQE 200
+ + + ++ +S +V+ + ++ L +F + K+ A + H+ ++E
Sbjct: 1407 ---KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA-QSRFTQHQNTVKE 1462
Query: 201 LLKSQQDHSASVNKGQEKAEELHRM--EVESLNKMLEELRLERKKLIEDYEGKLNKAQSF 258
L Q + EK E+++ + E++ NK + L+ E +ED + K+ K +S
Sbjct: 1463 L---QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE----MEDDKSKMEKKESN 1515
Query: 259 YERELDTLKRSQLFTAESLQASKEKEAD----LRKEFQGQEAILRKTIGKLKTELQMVQD 314
E EL + + +++ E K E + + K + Q+ I K +L +LQ Q+
Sbjct: 1516 LETELKS-QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK---ELVQKLQHFQE 1571
Query: 315 EAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ 374
++ ++ + + EN V ++ +L+ K+ + K E EL A +RL+
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 375 QAS----------DLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFL 424
+++ + + A +L + +E K ES S +N +L + E E L
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 425 RSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLE 484
K +S++ Q + ++ R KN+ + E+E KT E
Sbjct: 1692 EEKLKSVESSQSETLI----------------VPRSAKNVAAYTEQEEADSQGCVQKTYE 1735
Query: 485 ELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDK 544
E I + N + +K+KL + ++ + + E + Q Q+ L L+ E K
Sbjct: 1736 E-------KISVLQRN-LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA-EAK 1786
Query: 545 LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNV 604
+ IGHLQ+ + + + LI + +E +N + + K L NV
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYS----LIVAQHVEKEGGKNNI--------QAKQNLENV 1834
Query: 605 EGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDK 664
++++ Q+ E T ++++ K + E+ E +E + E+L+ + D
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE--MEELTSKYEKLQALQQMDG 1892
Query: 665 KSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQ 724
++ ++LL+ EK+ + K LL+ + +LE +L+ ++ +
Sbjct: 1893 RNKPTELLEENTEEKSKSHLVQPK----LLSNMEAQHNDLEFKLAGAE-----------R 1937
Query: 725 ERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSL 784
E+Q+L +E+ L++ + K ++ + + ++E+E++ + + L+ KH++ L+ L
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL 1997
Query: 785 KDAHRESMEGFRIEMEQELQTLRFELEDE-GKAMLASLRSELNHQHAAAIDLLRHNHHQE 843
M F ++ Q+ Q L +++ KA + +EL H + L ++
Sbjct: 1998 -------MREFNTQLAQKEQELEMTIKETINKAQ--EVEAELLESHQEETNQLLKKIAEK 2048
Query: 844 LAAAKMELERSIDISRRQSKEHICRITDLQEELRH-REHHISELDKEVQHLHENISALTK 902
K +R +I + +E ++ DLQ +L ++ + +L++E ++N++ +
Sbjct: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
Query: 903 ELEFKGKEILRIRSE-SNQQIRLHEQDLNKRLEK 935
+ + K L S+ Q+ R +L RL+K
Sbjct: 2109 QTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 154 bits (390), Expect = 4e-37
Identities = 256/1100 (23%), Positives = 472/1100 (42%), Gaps = 154/1100 (14%)
Query: 31 GHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE------------ 78
G + +E+HL + ++ +L +++ L K E S + L++A E
Sbjct: 505 GQKEEQQEELHLAVRER-ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563
Query: 79 -EIQQILAETREKILQYKSKV----TEELDLRR---KIQVLESSLE-DHIKMKQQALTEF 129
E+ LA + I + S TE DLR K+ L +L D + + QQ L
Sbjct: 564 TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
Query: 130 EAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALED 189
E + M+ +A++ ++ ++ E ++ E L+ Q +K + E
Sbjct: 624 EENQSVCSRMEAAEQARNALQV-----DLAEAEKRREALWEKNTHLEAQLQKAEEAGAE- 677
Query: 190 LQAAHRREIQELLKSQQDHSASVNKGQEKA----EELHRMEVESLNKMLEELRLERKKLI 245
LQA R+IQE + Q + QE A E+LH+ E + ++L E++ L+
Sbjct: 678 LQA-DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ-EAKRQEEVLARAVQEKEALV 735
Query: 246 EDYEGKLNKAQSFYERELDTLKRSQLFTAESLQ---ASKEKEADLRKEFQGQEAILRKTI 302
+ ++ E L ++R + AE LQ ++KE E Q Q +++ T
Sbjct: 736 RE--------KAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
Query: 303 GKLKTELQMVQDEAGSLLD---KCQKLQ--TALAIAENNVQVLQKQLDDAK-EGEMALLS 356
G+L+ ++Q V +A ++ +C KL+ T + AE +QL A+ EG+ AL
Sbjct: 788 GQLEVQIQTVT-QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Query: 357 KHKEVESELAAARERLQQQASDLVLK-ASHIGMLQATQMTQEVTIKDLESEKSRVNERLS 415
+ E E+ RE+ +++ S + A + L+ +M E+ +K+ ++E + +
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ---A 903
Query: 416 QLEEERAFLRSKTQSLDEEQKQQ-------ILELEKKVNEA----KRTQQEYYERELKN- 463
Q EEER S + E +++ +L+ +K++ +A +R +Q+ ++LK
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Query: 464 -----LQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE----- 513
LQ++L+E +L EA + ++LA A++ S+ ++DK LQ +E
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHRDDLA-----ALQEESSSLLQDKMDLQKQVEDLKSQ 1018
Query: 514 -----------EQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKS 562
EQ ++KL ++ N++Q+ELE K L L Q + LQ+
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 563 EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
+Q L + + Q Q+ L +++L + +KE K+A L QE Q EE A+
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKE-KEA-----DFLAQEAQLLEELEASH 1132
Query: 623 KEEEKLKVDKMAHDLEIKWTE-NLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 681
E++L+ A + + + LR S+L Q ++ A +QL L + A
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 682 ARDSWQKKVE----------------DLLNQISLLKQNLEI-------------QLSQSQ 712
+ + E D SL K+ + +L Q
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 713 TSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK--EKEQRALE 770
QQ + + Q+L + L + E + Q H L++ Q EE+ E +Q +LE
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE 1312
Query: 771 NHLQQKHS--AELQS-LKDAHRESME--GFRIEMEQELQTLRFELEDEGKAMLASLRSEL 825
+ L + H A LQS L+ A + ME G R ++ + L ++E +A + R++
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE-HLQAAVVEARAQA 1371
Query: 826 NHQHAAAIDLLRHNHHQELAAAKMELERS-IDISRRQSKEHICRITDLQEELRHREHHIS 884
+ DL +L ++E ER + Q + + + LQE L ++
Sbjct: 1372 SAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLA 1431
Query: 885 ELDKEVQHLHENISALTKELEFKGKEILRIRS----ESNQQIRLHEQDLNKRLEK----- 935
E ++EV+ L I L K+ E + K L + S + NQ++ L ++ + + LEK
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQ-KAALELLSLDLKKRNQEVDLQQEQI-QELEKCRSVL 1489
Query: 936 -ELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMIT 994
L + + ++ + R + + + L+ L E+E+K M ES+ +Q
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ--- 1546
Query: 995 ELKAMLTERDQIIKKLIEDN 1014
+LK L + + +L E++
Sbjct: 1547 DLKKQLVTLECLALELEENH 1566
Score = 138 bits (348), Expect = 3e-32
Identities = 231/1014 (22%), Positives = 448/1014 (44%), Gaps = 159/1014 (15%)
Query: 78 EEIQQILAETREKILQYKSKV----TEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYK 133
+++Q+ L++ +E+ +++ K +E ++L + L+S L + +A E E +
Sbjct: 1288 QDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
Query: 134 HRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQL------QVQFEKDKRLAL 187
E+ L A+ +H+Q V +R EE LR+ +V+ E+++ AL
Sbjct: 1348 AAKEN--LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 188 ED---LQAAHRREIQELLK------SQQDHSASVNKGQ----EKAEELHRMEVESLNKML 234
++ L+ A + +QE L ++++ +GQ EK E+ + +E L+ L
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL 1465
Query: 235 EELRLERKKLIEDYEGKLNKAQSFYER-ELDTLKRSQLFTAESLQASKEKEADLRKEFQG 293
++ R + L ++ +L K +S E + +R Q T + +E+ +L K+ +
Sbjct: 1466 KK-RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ-----REQIRELEKDRET 1519
Query: 294 QEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQT----ALAIAENN-----VQVLQKQL 344
Q +L + +L+ + QM++ + G + D ++L T AL + EN+ Q L K+L
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKEL 1579
Query: 345 DDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML--QATQMTQEVT--- 399
+ +E + L+ + +L + LQ Q+S + SH +L + + QEV
Sbjct: 1580 EGQRETQRVALT---HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 400 --IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYY 457
I++L+ +K + + L + ++E + + Q L++++ +Q LE+ + + K + +E
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER- 1695
Query: 458 EREL---KNLQSRLEEEVTQLNEAHSKTLEELAW-----KHHMAIEAVHSNAIRD-KKKL 508
REL + L EE ++A +LE + + + + H + +++ K +L
Sbjct: 1696 GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQL 1755
Query: 509 QMDLEEQHNK---DKLNLEEDKNQ---LQQELENLKEVLEDKLNTANQEIGHLQDMVRKS 562
+ L+ H K L L + + + LQQ+L+ +E E K + ++ Q + +
Sbjct: 1756 EQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQR 1815
Query: 563 EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
+Q L + + Q +ER++ + D + +L++ L GEL+ ++Q A
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ------AR 1869
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEE--DKKSAMSQLLQLKDREKN 680
+ EE+L V E + + L + LR E R Q + + ++ Q + E
Sbjct: 1870 RLEEELAV-------EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922
Query: 681 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 740
A +DSW + L + Q LE ++SQ+S Q +A E L+E
Sbjct: 1923 ALQDSWLQAQAVLKER----DQELEALRAESQSSRHQEEA--------ARARAEALQEAL 1970
Query: 741 QQRHKSL--KEAHVLAFQTMEEEKEKEQRALENHLQ--QKHSAELQSLKDAHRESMEGFR 796
+ H +L KE H+L + E L+ L Q HS +L+ E R
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE----------EALR 2020
Query: 797 I-EMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSI 855
I E E + Q LR++ ED +L A + LRH +E LE+S
Sbjct: 2021 IQEGEIQDQDLRYQ-EDV---------QQLQQALAQRDEELRHQQERE-----QLLEKS- 2064
Query: 856 DISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIR 915
+++R + I +L +E RE ++E++ LH+++ L L K +EIL +R
Sbjct: 2065 -LAQRVQENMIQEKQNLGQE---RE------EEEIRGLHQSVRELQLTLAQKEQEILELR 2114
Query: 916 S-----------ESNQQIRLHEQ-----DLNKRLEKELDVMTADHLREKNIMRADFNKTN 959
S++ + EQ L RL++EL+ + A LR+ ++ +
Sbjct: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKA 2173
Query: 960 ELLKEINAALQVSLEEMEE-------KYLMRESKPEDIQMITELKAMLTERDQI 1006
+ L A + S+ ++E L R+S+ + +Q EL E++++
Sbjct: 2174 QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227
Score = 134 bits (336), Expect = 6e-31
Identities = 213/939 (22%), Positives = 427/939 (45%), Gaps = 133/939 (14%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKV 98
E + KM K + + +++ +T+ EHE+++ + +QQ++ + + +++ +
Sbjct: 300 EDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359
Query: 99 TEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSRE- 157
+ S E+ +++ ++F+ Y+ + + L V+ ++T R+
Sbjct: 360 AQ-----------GSGHENSLELDSSIFSQFD-YQDADKALTL------VRSVLTRRRQA 401
Query: 158 VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQE 217
V+++R++ + LQ Q ++ E+ A R+ +Q+L + + Q
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQ-----WEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Query: 218 KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 277
+ + L + E E L K EELR ++ +++E +L + + + D+ + + E L
Sbjct: 457 EVDSLSK-ERELLQKAREELR-QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
Query: 278 QASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDE--AGSLLDKCQ-KLQTALAIAE 334
+ + L++ G EA +++ +L T + ++ G LL + Q ++ ALA AE
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574
Query: 335 NNVQVLQKQLDDAKEGEMALLS----KHKEVESELAAARERLQQQASDLVLKASHI-GML 389
++ L ++ + E+A L K + LA + L QQ L + + +
Sbjct: 575 QSIAELSSS-ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRM 633
Query: 390 QATQMTQEVTIKDL-ESEKSR---------VNERLSQLEEERAFLRSKTQSLDEEQKQQI 439
+A + + DL E+EK R + +L + EE A L++ + + EE++
Sbjct: 634 EAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE--- 690
Query: 440 LELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH--SKTLEELAWKHHMAIEAV 497
E++KK++E++ Q E TQL + H +K EE+ + EA+
Sbjct: 691 -EIQKKLSESRHQQ---------------EAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 498 HSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENL---KEVLEDKLNTANQEIGH 554
+R+K L++ L+ +E D+ L ++L+ L KE+LE L A Q+
Sbjct: 735 ----VREKAALEVRLQA--------VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSV 782
Query: 555 LQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA----LLNVEGE--- 607
++ + E + + +Q L+ ELD + ++ +DA L E E
Sbjct: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 608 -LEQERQQHEETIAAMKEEEKLKVDKMAHDLEI-KWTENLRQECSKLR----------EE 655
LEQ++ HE+ + ++ EK + ++ H E+ K E+L +E +L E
Sbjct: 843 ALEQQKAAHEKEVNQLR--EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 656 LRLQHEEDKKSAMSQLLQLK---DREKNAARDS---WQKKVEDLLNQISLLKQNLEIQLS 709
++ Q EE++ A S L Q++ ++E+ + ++ QK++ D Q+ L+Q++++Q
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 710 QSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL 769
+ Q + LQ Q QE QR EL+E QH+ +L+E Q + +++ +
Sbjct: 961 KEQETTGILQTQL-QEAQR---ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 770 ENHLQQKHSAEL--QSLKDAHRESMEGFRI--EMEQELQTLRFEL-EDEGKAMLASLRSE 824
+ Q S L Q +++ RE+ E RI E+E+E +L L E E + ++
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 825 LNHQHAAAI--DLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHH 882
+ Q +A+ D+ Q+ +A+MEL R ++ +++ + + + L EEL H
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQ-EVKEKEA-DFLAQEAQLLEEL--EASH 1132
Query: 883 ISELDKEVQHLHENISALTKELEFKGKEI-LRIRSESNQ 920
I+E Q L ++ A E K ++ LR+RS +Q
Sbjct: 1133 ITE-----QQLRASLWA----QEAKAAQLQLRLRSTESQ 1162
Score = 96.3 bits (238), Expect = 1e-19
Identities = 164/752 (21%), Positives = 326/752 (43%), Gaps = 114/752 (15%)
Query: 64 EHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQ-------VLESSLE 116
EH +Q LKD E+++Q + + E L + E + L++++Q + E SL+
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 117 DHIKMKQQALTEFEAYKHRVEDMQLCAEAQH---VQRIVTMSREVEEIRRKFEEKLRSFG 173
+ Q+AL + + ++ Q A+ Q ++ + +E+ +E+ G
Sbjct: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER---HG 1859
Query: 174 QLQVQFEKDKRLALEDLQAAHRR--EIQELL-----KSQQDHSASVNKGQEKAEELHRME 226
+LQ E+ +RL E+L RR ++E+L +S++ A + Q+ AE+ E
Sbjct: 1860 ELQDHKEQARRLE-EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 227 VESLNKMLEELRLERKKLIEDYEGKLN--KAQSFYERELDTLKRSQLFTAESLQASKEKE 284
VE+ + L++ L+ + ++++ + +L +A+S R + R++ AE+LQ + K
Sbjct: 1919 VET--RALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR---AEALQEALGK- 1972
Query: 285 ADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ----KLQTALAIAENNVQVL 340
QG+E L + +L L+ + LD CQ +L+ AL I E +Q
Sbjct: 1973 --AHAALQGKEQHLLEQ-AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 341 Q-KQLDDAKEGEMALLSKHKEV----ESELAAARERLQQQASDLVLKASHIGMLQATQMT 395
+ +D ++ + AL + +E+ E E + Q+ +++ + ++G Q
Sbjct: 2030 DLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG-----QER 2084
Query: 396 QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 455
+E I+ L + L+Q E+E LR + QQ LE + K + E
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELR---------ETQQRNNLEALPHSHKTSPME 2135
Query: 456 YYERELKNLQSRLEEEVTQLNEAHSKT-LEELAWK---HHMAIEAVHSNA-IRDKKKLQM 510
+L +L+ RL+ E+ +L A +T E+ W+ +A+ + A + +++ M
Sbjct: 2136 EQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195
Query: 511 DLEEQHNKDKLNLEEDKNQLQQELENLKEVLE-DKLN----TANQEIGHLQDMVRKSEQG 565
L+ L + ++ +LQ ELE + LE ++L+ T+ E+G + EQG
Sbjct: 2196 FLQ----ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELG------SRGEQG 2245
Query: 566 --LGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMK 623
LG G+ E + + +E + ++R +H + A
Sbjct: 2246 VQLGEVSGV-----------------------EAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
Query: 624 EEEKLKVDKMAHDLEIKWT-ENLRQECSKL-REELRLQHEEDKKSAMSQLLQLKDREKNA 681
E ++ ++ + H+++++ T E + +E KL RE +R + + + ++
Sbjct: 2283 EIDRSRLQR--HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG 2340
Query: 682 ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQ 741
++S K V +L ++ LL+ L ++ Q Q + + AQ ++E L H
Sbjct: 2341 QKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITR-SAQTSRELAGL---------HHS 2390
Query: 742 QRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 773
H L A +E E + +L L
Sbjct: 2391 LSHSLLAVAQAPEATVLEAETRRLDESLTQSL 2422
Score = 79.3 bits (194), Expect = 2e-14
Identities = 159/771 (20%), Positives = 318/771 (41%), Gaps = 108/771 (14%)
Query: 325 KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ---------Q 375
K Q+ + E V LQ+Q+ + + L +E + A +LQ Q
Sbjct: 12 KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ 71
Query: 376 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ 435
+ L+A+ + Q + +E + +L +R L E LR + D
Sbjct: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
Query: 436 KQQILELEKKVNEAKRT-------------QQEYYERELKNLQSRL----EEEVT----- 473
K ++EK + R +QE+++ LK RL E VT
Sbjct: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
Query: 474 -QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQ---------MDLEEQHNKDKL-- 521
++ A + L EL +H ++ + +R Q MD E L
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA 251
Query: 522 ---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 578
LE++ ++ QEL LK + + + L ++ +S++ E +I +L++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 579 S--------QERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA-AMKEEEKLK 629
+ E +++E L++++ +E K +L V ++ Q + + IA E L+
Sbjct: 312 TVEILETNHTELMEHEASLSRNA-QEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Query: 630 VDKMA------HDLEIKWT-------------ENLRQECSKLREELR-LQHEEDKKSAMS 669
+D D + T ++LRQ+ + +E + LQ + D+
Sbjct: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG 430
Query: 670 QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRL 729
+ L+ + ++ RD+ + DL ++ L + E+ L +++ L+Q QE RL
Sbjct: 431 KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL-LQKAREELRQQLEVLEQEAWRL 489
Query: 730 TQELEELEEQ----HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK 785
+ EL+ Q Q+ + +E H+ E E+ +E Q + +EL +L+
Sbjct: 490 RRVNVELQLQGDSAQGQKEEQQEELHL---AVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 786 DAHRES-MEGFRIEMEQELQTLRFELEDEGKAMLAS----LRSELNHQHAAAIDLLRHNH 840
+A S +EG + EQ T ++ A L+S L++E+ AAA+ L N
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN- 605
Query: 841 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR-EHHISELDKEVQHLHENISA 899
+ LA K+ L + + + + + +C + E+ R+ + ++E +K + L E +
Sbjct: 606 -EALALDKVGLNQQL-LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 900 LTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEK----------ELDVMTADHLREKN 949
L +L+ K +E + I+ ++++ K+L + +L+ + + R++
Sbjct: 664 LEAQLQ-KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722
Query: 950 IMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAML 1000
++ + L++E AAL+V L+ +E R+ E +Q ++ K +L
Sbjct: 723 VLARAVQEKEALVRE-KAALEVRLQAVERD---RQDLAEQLQGLSSAKELL 769
Score = 46.6 bits (109), Expect = 1e-04
Identities = 92/484 (19%), Positives = 202/484 (41%), Gaps = 49/484 (10%)
Query: 38 QEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSK 97
Q+ L+ + + + + AL ++ +A + A E +Q+ L + + +
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR-ARAEALQEALGKAHAALQGKEQH 1983
Query: 98 VTEELDLRRKIQV----LESSLED---HIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR 150
+ E+ +L R ++ L++SL+ H + ++AL E + + +D++ + Q +Q+
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG-EIQDQDLRYQEDVQQLQQ 2042
Query: 151 IVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDL-QAAHRREIQELLKSQQDHS 209
+++ EE+R + E + L + +++ ++L Q EI+ L +S ++
Sbjct: 2043 --ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE-- 2098
Query: 210 ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
+ Q++ E L E + N + + +E+ KL+ + +REL+ L+
Sbjct: 2099 LQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQ-- 2156
Query: 270 QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK---CQKL 326
+L+ ++ +E + R++ Q L +T + + ++ S+L++ Q+L
Sbjct: 2157 -----AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 327 QTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKAS-- 384
Q L + ++ +++L A L E +L + + D + K S
Sbjct: 2212 QDELELTRRALE--KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269
Query: 385 -HIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELE 443
+ LQ E+ L+ ++ L Q+E ER L+ + + +I
Sbjct: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI---- 2325
Query: 444 KKVNEAKRTQQE-------------YYERELKNLQSRLEEEVTQLNE---AHSKTLEELA 487
K + TQQ+ ++E+ LQ++L E Q + ++T ELA
Sbjct: 2326 SKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELA 2385
Query: 488 WKHH 491
HH
Sbjct: 2386 GLHH 2389
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 154 bits (390), Expect = 4e-37
Identities = 230/1044 (22%), Positives = 423/1044 (40%), Gaps = 170/1044 (16%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQ---------ALKDAHEEEIQQILAETRE 89
E + ++KI+ T + AL K E + A +H EI+Q LA R+
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
Query: 90 KILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHV- 148
Q+ L+L K+ L + +E + K + L + E K +VED+Q E + +
Sbjct: 398 GHDQHV------LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 451
Query: 149 --------------------------------------QRIVTMSRE--VEEIRRKFEEK 168
R+ T+S + + E+ + +
Sbjct: 452 KGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALR 511
Query: 169 LRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK----SQQDHSASVNKGQE---KAEE 221
++ +L+ + E +K D+ + +EI L + ++ DH + +E EE
Sbjct: 512 VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE 571
Query: 222 LHRMEV--------------ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK 267
H+ E+ ESL LE E +I ++ KL A + +++ ++ LK
Sbjct: 572 THQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK 631
Query: 268 RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ-KL 326
S ++ L + A+L+ + + + I L+ + + ++ + KL
Sbjct: 632 VS---FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 688
Query: 327 QTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHI 386
+ EN+++ ++ +LD A++ + E+E L +LQ+ +K +
Sbjct: 689 MKVIKEKENSLEAIRSKLDKAEDQHLV------EMEDTL----NKLQEAE----IKVKEL 734
Query: 387 GMLQATQMTQEVTIKDLESEKSRVNERLSQLE-------EERAFLRSKTQSLDEEQKQ-Q 438
+LQA Q I + S+ E+L L+ E ++ ++ Q L+ +KQ +
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 794
Query: 439 ILELEKKVNEAKRTQ--QEYYERELK--NLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 494
LE+EK +K + +E RELK NLQ L EV+Q+ E K L+ L K A
Sbjct: 795 HLEIEKNAESSKASSITRELQGRELKLTNLQENL-SEVSQVKETLEKELQILKEKFAEAS 853
Query: 495 EAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH 554
E A+ ++ +Q + + H K EE N L +LE L+E L D + +E
Sbjct: 854 E----EAVSVQRSMQETVNKLHQK-----EEQFNMLSSDLEKLRENLAD-MEAKFREKDE 903
Query: 555 LQDMVRKSEQGL-----------GSAEGLIASLQDS---QERLQNELDLTKDSLKETKDA 600
++ + K+++ L G + + D +ER EL L E
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 963
Query: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLR------- 653
L ++ + +Q ++ A EEEK ++++ DLE K E +C +L+
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE-KKMETSHNQCQELKARYERAT 1022
Query: 654 EELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI-SLLKQNLEIQLSQSQ 712
E + +HEE ++ LL +D+ K A ++ LL ++ L KQ + + +Q+
Sbjct: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREEN-----SGLLQELEELRKQADKAKAAQTA 1077
Query: 713 TSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE-EKEKEQRALEN 771
Q+ Q T+E+ LE+ ++ + + L + +EE K KE +EN
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1137
Query: 772 HLQQKHSAELQSLKDAHRE------SMEGFRIEMEQELQTLRFELEDEGKAMLASLRSEL 825
++ E+++LK A + +++ +++ +EL R E+ K L RS L
Sbjct: 1138 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVL 1195
Query: 826 NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEE---LRHREHH 882
N+Q + ++ K L++SI I+ E + L+ E LR
Sbjct: 1196 NNQ-LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1254
Query: 883 ISELDKEVQHLHEN---ISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDV 939
L VQ L + + K LE + KE R S S+ + + E ++D
Sbjct: 1255 AKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1314
Query: 940 MTADHLREKNIMRADFNKTNELLK 963
+ N + D + N+ LK
Sbjct: 1315 L--------NSVIVDLQRKNQDLK 1330
Score = 139 bits (350), Expect = 2e-32
Identities = 175/854 (20%), Positives = 388/854 (45%), Gaps = 100/854 (11%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKD-------AHEEEIQQILAETREKI 91
+M L + ++I+ L + + T +H+ I +LK+ H++EI+ + T EK+
Sbjct: 532 DMSLSLLQEISSLQEKLEVTRT---DHQREITSLKEHFGAREETHQKEIKALYTAT-EKL 587
Query: 92 LQYKSKVTEELDLRRK-----IQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQ 146
+ + +L+ K I + +S LE I QQA+ E + + + A+
Sbjct: 588 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 647
Query: 147 HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQ 206
+ ++E++R ++ ++ + LQ Q + ++ ++++A R ++ +++K ++
Sbjct: 648 -------LKTQIEKMRLDYQHEIEN---LQNQQDSERAAHAKEMEAL-RAKLMKVIKEKE 696
Query: 207 DHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTL 266
+ ++ +KAE+ H +E+E L+E ++ K+L E + K N+ + L
Sbjct: 697 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQL 755
Query: 267 KRSQ--LFTAESLQ-ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC 323
K ++ L ++L+ AS E +++++K Q EA K I L+ E +A S+ +
Sbjct: 756 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLEIEKNAESSKASSITREL 814
Query: 324 QKLQTALAIAENNVQVLQKQLDDAKEGEMALLS-KHKEVESELAAARERLQQQASDLVLK 382
Q + L + N+ + Q+ + E E+ +L K E E + + +Q+ + L K
Sbjct: 815 QGRELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873
Query: 383 ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILEL 442
ML + + D+E++ +ER QL + + L + + + +L
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 443 EKKVNEAKRTQQEYYERELKNLQ-----SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAV 497
K +E + +++ E +LK + S L++ + + ++ +E A KH E
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEE 989
Query: 498 HSNAIRDKKKLQMDLEEQHN-------KDKLNLEEDKNQLQQELENLKEVL---EDKLNT 547
R L+ +E HN + + E K + ++ L+NL++ L EDKL
Sbjct: 990 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
Query: 548 ANQEIGHL--------------------QDMVRKSEQGLGSAEGLIASLQDSQE---RLQ 584
A +E L +D ++ EQ +ASL+D+++ +LQ
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109
Query: 585 NELD-LTKDSLKETKD-----ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 638
NELD L +++LK ++ LL VE + +E ++ ET+ ++ ++ + +
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-N 1168
Query: 639 IKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQIS 698
+K E L + ++ +L EE++ +QLL++K RE +D+ ++K L IS
Sbjct: 1169 VKLAEELGRSRDEVTSHQKL--EEERSVLNNQLLEMKKRESKFIKDADEEKA-SLQKSIS 1225
Query: 699 -----LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVL 753
L +++ E++ +++ ++ + + + + Q LE + + + + K+L+
Sbjct: 1226 ITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLE----- 1280
Query: 754 AFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDE 813
++ ++ K Q + + + E + +++ + + ++++++ Q L+ ++E
Sbjct: 1281 ----LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
Query: 814 GKAMLASLRSELNH 827
+A L +LN+
Sbjct: 1337 SEAALNGNGDDLNN 1350
Score = 122 bits (305), Expect = 3e-27
Identities = 202/954 (21%), Positives = 404/954 (42%), Gaps = 163/954 (17%)
Query: 160 EIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKA 219
E ++ K+ LQ K+K+ +E L A E E+ K+ H + + A
Sbjct: 338 ETSSRYARKISGTTALQEAL-KEKQQHIEQLLAERDLERAEVAKATS-HVGEIEQELALA 395
Query: 220 EELHRMEVESLNKMLEELRL-------ERKKLIEDYEGKLNKAQSFYER-ELDTLKRSQL 271
+ H V L +++LR E+ +L+ E + K + R E +++ + L
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 272 FTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 331
T L+ ++ KE + F+ +A KL+ EL+ + S + +L+ LA
Sbjct: 456 ETQTKLEHARIKELEQSLLFEKTKA------DKLQRELEDTRVATVSEKSRIMELEKDLA 509
Query: 332 IAENNVQVLQKQLDDAKEG-----EMALLSKHKEVESELAAARERLQQQASDL-----VL 381
+ V L+++L+ K ++LL + ++ +L R Q++ + L
Sbjct: 510 LRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 382 KASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILE 441
+ +H ++A E K+ ES KS++ + + A +SK ++ +Q + E
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Query: 442 LEKKVNEAKRTQQEY--------------YERELKNLQSRLEEEVTQLNEAHSKTLEELA 487
L+ ++ T+ Y+ E++NLQ++ + E AH+K +E L
Sbjct: 630 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE----RAAHAKEMEALR 685
Query: 488 WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKE--VLEDKL 545
K I+ ++ + KL E+QH + +E+ N+LQ+ +KE VL+ K
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDK-AEDQH---LVEMEDTLNKLQEAEIKVKELEVLQAKC 741
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
N + I + ++ +E+ L LDL D+L++ +
Sbjct: 742 NEQTKVIDNFTSQLKATEEKL--------------------LDL--DALRKASS---EGK 776
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
E+++ RQQ E AA K+ + L+++K A E ++ +E EL+L + ++
Sbjct: 777 SEMKKLRQQLE---AAEKQIKHLEIEKNA---ESSKASSITRELQG--RELKLTNLQENL 828
Query: 666 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
S +SQ+ + ++E ++ + + E+ ++ ++ + ++ L Q + QF
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVS--------VQRSMQETVNKLHQKEEQFNM- 879
Query: 726 RQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQ------KHSA 779
L+ +LE+L E +E EE+ K + LEN + + +S+
Sbjct: 880 ---LSSDLEKLRENLADMEAKFREK-----DEREEQLIKAKEKLENDIAEIMKMSGDNSS 931
Query: 780 ELQSLKDAHR---ESMEGFRIEMEQELQTLRF---ELEDEGKAMLASLRSELNHQHAAAI 833
+L + D R +E ++++ + + F +ED ++++E + Q AA
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED------MTVKAEQSQQEAAK- 984
Query: 834 DLLRHNHHQ-ELAAAKMELERSIDISRRQSKEHICRI--------TDLQEELRHREHHIS 884
+H + EL +LE+ ++ S Q +E R T +E L++ + +
Sbjct: 985 ---KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1041
Query: 885 ELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQ--IRLHEQ--------------- 927
+ + +++ E S L +ELE K+ + ++ + +++ EQ
Sbjct: 1042 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1101
Query: 928 -DLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESK 986
N +L+ ELD + ++L KN+ + NK+ ELL N ++ +E+E K
Sbjct: 1102 KQTNAKLQNELDTLKENNL--KNV--EELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 987 PEDIQMITELKAMLTE-----RDQII--KKLIEDNKFYQ---LELVNRETNFNK 1030
+ + + E L E RD++ +KL E+ LE+ RE+ F K
Sbjct: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1211
Score = 106 bits (265), Expect = 1e-22
Identities = 171/797 (21%), Positives = 333/797 (41%), Gaps = 150/797 (18%)
Query: 363 SELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKD-------LESEKSRVNERLS 415
S A++ + AS + + S G+L T I L+ ++ + + L+
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369
Query: 416 QLEEERAFLRSKTQSLDEEQK----------QQILELEKKVNEAKRTQQEYYERELKNLQ 465
+ + ERA + T + E ++ Q +LELE K+++ RT E +RE L
Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL-RTMVEAADREKVELL 428
Query: 466 SRLEEEVTQLNEAHSKTLEELAWK---------HHMAIEAVHSNAIRDK---KKLQMDLE 513
++LEEE ++ + + EE K H I+ + + + +K KLQ +LE
Sbjct: 429 NQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE 488
Query: 514 E------QHNKDKLNLEEDKNQLQQELENLKEVLE--------DKLNTANQEIGHLQDM- 558
+ + LE+D QE+ L+ LE D + QEI LQ+
Sbjct: 489 DTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL 548
Query: 559 ----------VRKSEQGLGSAEGL----IASLQDSQERLQNELDLTKDSL----KETKDA 600
+ ++ G+ E I +L + E+L E + K L KE D
Sbjct: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV 608
Query: 601 LLNVEGELEQERQQHEETIAAMK--------------EEEKLKVDKMAHDLEIKWTENLR 646
+ + +LE H++ + +K E K +++KM D + + ENL+
Sbjct: 609 IALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE-IENLQ 667
Query: 647 QECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA----------ARDSWQKKVEDLLNQ 696
+ ++ R H ++ ++ ++L+++ ++N+ A D ++ED LN+
Sbjct: 668 NQ----QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Query: 697 I--------------------SLLKQNLEIQLSQSQTSLQQLQA------QFTQERQRLT 730
+ + + N QL ++ L L A + E ++L
Sbjct: 724 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 783
Query: 731 QELEELEEQ--HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSA------ELQ 782
Q+LE E+Q H + K+ + + + + +E + L+ +L + ELQ
Sbjct: 784 QQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 843
Query: 783 SLKDAHRE-SMEGFRIEMEQELQTLRFELEDEGKAMLAS----LRSELNHQHAAAIDLLR 837
LK+ E S E ++ + + ++E ML+S LR L A + +
Sbjct: 844 ILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE--K 901
Query: 838 HNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI 897
++L AK +LE I + S ++ ++T + +ELR +E + EL ++ +EN
Sbjct: 902 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 961
Query: 898 SALTKELEFKGKEILRIRSESNQQ--IRLHEQDLNKRLEKELD----VMTADHLREKNIM 951
S L K + E + +++E +QQ + HE++ K LE++L M H + + +
Sbjct: 962 SFLQKSI-----EDMTVKAEQSQQEAAKKHEEE-KKELERKLSDLEKKMETSHNQCQELK 1015
Query: 952 RADFNKTNELL---KEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
T+E +EI LQ +L + E+K ++ ++ E+ ++ EL+ + + D+
Sbjct: 1016 ARYERATSETKTKHEEILQNLQKTLLDTEDK--LKGAREENSGLLQELEELRKQADKAKA 1073
Query: 1009 KLIEDNKFYQLELVNRE 1025
++ +E + +E
Sbjct: 1074 AQTAEDAMQIMEQMTKE 1090
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 154 bits (390), Expect = 4e-37
Identities = 229/1081 (21%), Positives = 467/1081 (43%), Gaps = 192/1081 (17%)
Query: 104 LRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRR 163
LR+++Q L++SL++ ++ E E Y+ + EA+ + S E++ + +
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ-----EAKPDGLVTDSSAELQSLEQ 142
Query: 164 KFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELH 223
+ EE Q + K + E A EI ++ KS+ D S+ +E AE+
Sbjct: 143 QLEE-----AQTENFNIKQMKDLFEQKAAQLATEIADI-KSKYDEERSL---REAAEQKV 193
Query: 224 RMEVESLNK---MLEELRLE--RKKLIEDY---EGKLNKAQSFYERELDTLKRSQLFTAE 275
E LNK ++++L+ E ++ IED + +L + Q+ + TL+R +
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM--TLERER----- 246
Query: 276 SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAEN 335
EK D K+ Q Q A TI +L++EL E + + QKL++++
Sbjct: 247 ----ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 336 NVQVLQKQLDDAKEGEMALLSKHKEV------------ESELAAARERLQQQASDLVLKA 383
Q L + L ++ L KH E + +L + + + AS+ L
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 384 SHIGMLQATQMTQEV--TIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ---Q 438
H+ + + + TQ++ + ++E++ + QL+++R L E Q +
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 439 ILELEKKVNEA-----------------KRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
+LE E+++ EA K Q + +L L+ +L+E+VT E +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE-------------------QHNKDKLN 522
+ + H +A+ + ++ Q DLE+ Q +K+ ++
Sbjct: 483 L--DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 523 LEEDK------------------NQLQ-------QELENLKEVLEDKLNTANQEIGHLQD 557
L E + NQLQ +++ L E L+++ + Q +L D
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 558 MVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD-------SLKETKDALLNVEGELEQ 610
V++ + L +A+ + SL+ S L ++L+ +K+ +K + LL+ E
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 611 ER---QQHEETIAAMKEEEKLKVDKMAHDLE--IKWTENLRQECSKLREELRLQHEEDKK 665
+R Q H +T ++++ +++K+ L+ ++ ++ CS+L L+ +++E
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK-EYKEKYL 719
Query: 666 SAMSQLLQLKDREKNAARDSWQKK------VEDLLNQISLLKQNLEIQLSQSQTSLQQLQ 719
S + +L+ + K DS + K ++DL Q L +LE++ ++ L+ +
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ-RQLNTDLELRATELSKQLEMEK 778
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQKH 777
+ R L ++ E LE Q+ K +E +L F+T+ +E + + L N +Q
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT- 837
Query: 778 SAELQSL---KDAHRESMEGFRIEMEQELQTLR-----FELEDE-GKAMLASLR---SEL 825
ELQ + K+A + + ++ + +L+ FE E++ GKA + L EL
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 826 NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISE 885
HQ + + N +E + EL++S++ + S + + +QE+L ++ + +
Sbjct: 898 KHQ----LQVQMENTLKE----QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ 949
Query: 886 LDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHL 945
+KE Q L NI+ L + E K K+I ++ E + L + +L +L+++L +
Sbjct: 950 NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV-LQKTELENKLQQQLTQAAQELA 1008
Query: 946 REK---NIMRADFNKTNELLKEINA----------ALQVSLEEMEEKYLM--------RE 984
EK ++++ ++ K+ E K++ + A + L+ +EEK + R
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068
Query: 985 SKPEDIQMITELKA--------------MLTERDQIIKKLIEDNKFYQLELVNRETNFNK 1030
++I ELK L ER + ++ + ++ + ELVN ++ +
Sbjct: 1069 QIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128
Query: 1031 V 1031
+
Sbjct: 1129 I 1129
Score = 152 bits (385), Expect = 1e-36
Identities = 223/1041 (21%), Positives = 450/1041 (43%), Gaps = 176/1041 (16%)
Query: 66 ESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
+S++ L ++ + +L + ++ + + K EE ++ IQ + + Q
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQD-YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSR 352
Query: 126 LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRL 185
L+ E HR+ ++L + + Q++ E+ E+ K++ F QLQ Q E+ ++
Sbjct: 353 LSASETSLHRIH-VELSEKGEATQKL---KEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 186 ALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLI 245
L+ L+S+ +N+ K E R E+ ++ E+ +L +KL+
Sbjct: 409 GLQ-------------LQSE------INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 246 EDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKL 305
D E ++ Q R + LK + E LQ +K +++ Q Q+A+ + T KL
Sbjct: 450 -DKEQQVADLQLKLSRLEEQLKEKVTNSTE-LQHQLDKT---KQQHQEQQALQQSTTAKL 504
Query: 306 K---TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD------AKEGEMALLS 356
+ +L+ V + G K Q L+ L ++ N+ +L+K+ +D A EGE A+L+
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 357 KHKE----VESELAAARERLQQQASD-----------LVLKASHIGMLQATQMTQEVTIK 401
+ +E ++ ++ E+L+ Q+ + + +H+ Q ++ E ++
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 402 DLESEKSRVNERLSQLEEERAFLRSKTQ---SLDEEQKQQILELEKKVNEAKRTQQEYYE 458
+L S+ + E++SQL+ + +++KT+ S + + Q +L+ ++ A+ Q+ +
Sbjct: 625 ELNSQLNESKEKVSQLDIQ---IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-Q 680
Query: 459 RELKNLQSRLEEEVTQLN---------EAHSK-------TLEELAWKHHMAIEAVHSNAI 502
+EL + ++L++ +L E+H K +LE+ + I+ + ++++
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 503 RDKKKLQMDLEEQHNKDKLN--LEEDKNQLQQELENLKEV-----------------LED 543
K + L++ + +LN LE +L ++LE KE+ ++
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 544 KLNTANQEIGHL-QDMVRKSEQGLGSAEGLIASLQDS----------QERLQNELDLTKD 592
KL +E L QD S++ E L +Q + +E L EL KD
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 593 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKL 652
L + D+L N + E E+E Q+ + I +L + C +L
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAIL-----------------------DLEKTCKEL 897
Query: 653 REELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQ 712
+ +L++Q E K +L + ++EK A+ +Q+ L +++ QL Q+Q
Sbjct: 898 KHQLQVQMENTLKE-QKELKKSLEKEKEAS------------HQLKLELNSMQEQLIQAQ 944
Query: 713 TSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENH 772
+L+Q + +E Q+L + EL++ +Q+ K ++ A Q + ++ LEN
Sbjct: 945 NTLKQNE----KEEQQLQGNINELKQSSEQKKKQIE-----ALQGELKIAVLQKTELENK 995
Query: 773 LQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLR------FELEDEGKAMLASLRSELN 826
LQQ+ + Q L A +E + + E+ +T + + E E A L+S
Sbjct: 996 LQQQLTQAAQELA-AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 827 HQHAAAIDLLRHNHH--------QELAAAKMELERSIDISRRQSKEHICRITDLQEELRH 878
A DL+ + + QEL AK LE+ +Q +E + D+Q+E
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 879 REHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELD 938
+E + ++ + E KE+ +E+ + ES ++I + ++++L+
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 939 VM-TADHL--------REKNIMRADFNKTNELLKEINAALQVSL-EEMEEKYLMRESKPE 988
+ AD L R + I++ K E LK+ + L E++EK + + E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 989 DIQMITELKAMLTERDQIIKK 1009
+ +T L E +KK
Sbjct: 1235 NEAKLTMQITALNENLGTVKK 1255
Score = 133 bits (334), Expect = 1e-30
Identities = 207/978 (21%), Positives = 431/978 (44%), Gaps = 121/978 (12%)
Query: 50 QLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQ 109
QL I L++K E E + L +AH +Q + EK++ + +V DL+ K+
Sbjct: 411 QLQSEINQLHSKLLETE---RQLGEAHGRLKEQRQLSS-EKLMDKEQQVA---DLQLKLS 463
Query: 110 VLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKL 169
LE L++ + + + + K + ++ Q ++ ++ ++E++ R+ +K
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST-TAKLREAQNDLEQVLRQIGDKD 522
Query: 170 RSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVES 229
+ L+ +K K L R ++ +++ + +A +N+ QEK L +V
Sbjct: 523 QKIQNLEALLQKSKENI--SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQ 579
Query: 230 LNKMLEELRLERKKLIEDYEGKLNKAQSFYERELD---TLKRSQLFTAESLQASKEKEAD 286
L + L+ K+ E+ ++ + ++ D +L+ S L SKEK +
Sbjct: 580 LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639
Query: 287 LRKEFQG--------------QEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAI 332
L + + Q A L+ + + LQ Q E + + ++ L
Sbjct: 640 LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699
Query: 333 AENNVQVLQKQLDDAKEGEMALLSKHKEVES----------ELAAARER----LQQQA-- 376
+ + L+ L + KE ++L K +E+E E+ A++E+ LQQQ
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
Query: 377 -SDLVLKASHIGMLQATQMTQEV---TIKDLESEKSR---VNERLSQLEEERAFLRSKTQ 429
+DL L+A+ + + +M +E+ T DL+ + + ++L++ EEE+ L+ +
Sbjct: 760 NTDLELRATELS--KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
Query: 430 SLDEEQKQQILELEKKVN------EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL 483
+L +E K Q EL ++ + + ++E EL ++ +L + L + S+
Sbjct: 818 TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 484 EELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV--- 540
+E AI D +K +L+ Q N +++ +L++ LE KE
Sbjct: 878 KE---------NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
L+ +LN+ +++ Q+ ++++E+ +G I L+ S E+ + +++ + LK
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKL--REELRL 658
+E +L+Q+ Q + +AA KE K+ + ++ E K E +Q S RE L
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKE----KISVLQNNYE-KSQETFKQLQSDFYGRESELL 1043
Query: 659 QHEEDKKSAMSQL-LQLKDREKNAARDSWQKK-VEDLLNQISLLKQNL---EIQLSQSQT 713
+D KS +L L +D N + Q K +++L + L+Q+ E QL +
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 714 SLQQLQAQFTQERQRLTQE---LEELEEQHQQRHKS-------LKEAHVLAFQTMEEEKE 763
+LQ +Q + + + + L E L E+EE ++ K LK + + + + K+
Sbjct: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163
Query: 764 KEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 823
+Q ++ L+ + A+ SLK A + +I ++ +++ EL+ E A L S
Sbjct: 1164 AKQLLIQQKLELQGKAD--SLKAAVEQEKRNQQI-LKDQVKKEEEELKKEFIEKEAKLHS 1220
Query: 824 ELNHQHAAAIDLLRHNHHQ-ELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHH 882
E+ + + + +H ++ +L L ++ +++ + R+++L+++
Sbjct: 1221 EIKEKE---VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGE 1277
Query: 883 ISELDKEVQHLHENISAL---------------TKELEFKGK-----EILRIRSESNQQI 922
I+ L+ VQ+ + AL TK LE + K ++ NQ +
Sbjct: 1278 IAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
Query: 923 RL-HEQDLNKRLEKELDV 939
++ H Q LN++ ++ +V
Sbjct: 1338 QIKHTQALNRKWAEDNEV 1355
Score = 116 bits (291), Expect = 1e-25
Identities = 171/836 (20%), Positives = 376/836 (44%), Gaps = 118/836 (14%)
Query: 32 HSMDYSQEMHLKMSK-KIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREK 90
H Q+ HL+ ++ ++ L + LN++ +E + + L QI A+T
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI-------QIKAKTELL 651
Query: 91 ILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR 150
+ +K + DL+ + +++L+D + + T+ + +++D Q +H +
Sbjct: 652 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ-----EHCSQ 706
Query: 151 IVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSA 210
+ + +E +E E+K +L+ Q +K + +LE ++A+ + +Q+L + +Q
Sbjct: 707 LESHLKEYKEKYLSLEQKTE---ELEGQIKKLEADSLE-VKASKEQALQDLQQQRQ---- 758
Query: 211 SVNKGQE-KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
+N E +A EL + ++E +++ RL+ +K E L+++K+
Sbjct: 759 -LNTDLELRATELSK-QLEMEKEIVSSTRLDLQKKSE---------------ALESIKQK 801
Query: 270 QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTA 329
E Q K+ L +E + Q L I TELQ V+ E +L+ + ++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 330 LAIAENNVQVLQKQLD-DAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGM 388
L+ ++++ + + + + ++G+ A+L ++E + +LQ Q
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAIL----DLEKTCKELKHQLQVQ------------- 904
Query: 389 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 448
++ T Q+ K LE EK ++ +L + L +L + +K++ +L+ +NE
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE-QQLQGNINE 963
Query: 449 AKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW-KHHMAIEAVHSNAIRDKKK 507
K++ E +++++ LQ L+ V Q E +K ++L +A E + +++ +
Sbjct: 964 LKQS-SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 508 LQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLG 567
+ +Q D E + +Q+L++ +E+KL+ A +D++ Q +G
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKS----VEEKLSLAQ------EDLISNRNQ-IG 1071
Query: 568 SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEK 627
+ LI L+ ++ L+ + + L+E AL +++ E ++KE+E
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE------------KSLKEKEL 1119
Query: 628 L-KVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD-- 684
+ + K+A EIK + +E +KL EEL+ K ++ ++ LKD ++ +
Sbjct: 1120 VNEKSKLAEIEEIKCRQ--EKEITKLNEELK----SHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 685 SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE---EQHQ 741
Q K + L + K+N +I Q + ++L+ +F ++ +L E++E E ++H+
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 742 QRHKSLKEAHVLAFQ----TMEEEKEKEQRALENHLQQKH---------SAELQSLKDAH 788
+ L + A T+++E + QR + +Q A +Q+ +D
Sbjct: 1234 ENEAKL-TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDER 1292
Query: 789 RESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQEL 844
R +E ++ E E++ L + + L+ +L++ AA +L R N ++
Sbjct: 1293 RALLERC-LKGEGEIEKL--------QTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
Score = 106 bits (265), Expect = 1e-22
Identities = 172/761 (22%), Positives = 330/761 (43%), Gaps = 97/761 (12%)
Query: 17 AAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAH 76
+A+ A + A L H +D +Q + K +L K+ T+ D+ + +Q K H
Sbjct: 653 SAEAAKTAQRADLQNH-LDTAQNA---LQDKQQELNKI----TTQLDQVTAKLQD-KQEH 703
Query: 77 EEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRV 136
+++ L E +EK L + K TEEL+ +I+ LE+ + K+QAL + + +
Sbjct: 704 CSQLESHLKEYKEKYLSLEQK-TEELE--GQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 137 EDMQLCAEAQHVQRIVTMSREVEEIRR----KFEEKLRSFGQLQVQFEKDKRLALEDLQA 192
D++L A + + + M +E+ R K E L S Q + E++K++ +D +
Sbjct: 761 TDLEL--RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 193 AHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKL 252
+ +++ H N+ Q EL ++++E ++ EL + KL + L
Sbjct: 819 LSQ-------ETKIQHEELNNRIQTTVTELQKVKMEK-EALMTELSTVKDKLSK-VSDSL 869
Query: 253 NKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV 312
++S +E+E K + L ++ + K + + ++ L+K++ K K +
Sbjct: 870 KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929
Query: 313 QDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAA---- 368
+ E S+ ++ + Q L E Q LQ +++ K+ + + ++ EL A
Sbjct: 930 KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989
Query: 369 -------RERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEER 421
+++L Q A +L + I +LQ + T K L+S+ R S+L R
Sbjct: 990 TELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD---FYGRESELLATR 1046
Query: 422 AFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
L+S + L Q+ I + N+ K Q ELK ++ LE++ S
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ------ELKTAKATLEQD--------SA 1092
Query: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKL-NLEEDKNQLQQELENLKEV 540
E+ + A++ + K+K + E + K KL +EE K + ++E+ L E
Sbjct: 1093 KKEQQLQERCKALQDIQ------KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146
Query: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
L+ + +EI +L+D + Q +G SL+ + E+ + + KD +K+ ++
Sbjct: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
Query: 601 L----LNVEGELEQE-------RQQHEET-------IAAMKE------EEKLKVDKMAHD 636
L + E +L E ++HEE I A+ E +E + +
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 637 LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQ 696
LE K T++LR E + L E +Q+ +D++ A+ + + E + Q KV +L +
Sbjct: 1267 LE-KQTDDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE----IEKLQTKVLELQRK 1319
Query: 697 ISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 737
+ N + + Q LQ + TQ R E E++
Sbjct: 1320 L----DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 154 bits (390), Expect = 4e-37
Identities = 222/1013 (21%), Positives = 450/1013 (44%), Gaps = 135/1013 (13%)
Query: 72 LKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEA 131
L++ +E++ QI+ T+ + +V + L+R+ + + Q + F
Sbjct: 776 LEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRR---------EALFCIQYNVRAFMN 826
Query: 132 YKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQ 191
KH M+L + + + + +E+ ++ +F++ + + KR LE+
Sbjct: 827 VKHWPW-MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEA-----KRKELEEKM 880
Query: 192 AAHRREIQELLKSQQDHSASVNKGQEKAEEL--HRMEVESLNKMLEELRLERKKLIEDYE 249
+E +L Q + S+ +E+ E+L +++++E+ K + E E +++ +
Sbjct: 881 VTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELT 940
Query: 250 GKLNKAQ---SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLK 306
K K + S ++++D L+ + + A++ K +L +E G L +TI KL
Sbjct: 941 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG----LDETIAKLS 996
Query: 307 TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELA 366
E + +Q+ LD Q + + I L++Q+DD EG L + K++ +L
Sbjct: 997 KEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDL-EGS---LEQEKKLRMDLE 1052
Query: 367 AARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRS 426
A+ +L+ DL ++ QE T+ D+E++K +++E+L + E E + L S
Sbjct: 1053 RAKRKLE---GDL-------------KLAQESTM-DMENDKQQLDEKLEKKEFEISNLIS 1095
Query: 427 K---TQSLDEEQKQQILELEKKVN------EAKRTQQEYYERELKNLQSRLEEEVTQLNE 477
K Q+++ + +++I EL+ ++ EA+R + E++ +L LEE +L E
Sbjct: 1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 478 AHSKT--------------------LEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHN 517
A T LEE +H + A+ +L ++
Sbjct: 1156 AGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL-Q 1214
Query: 518 KDKLNLEEDKNQLQQELENLK---EVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIA 574
+ K LE++K++L+ E ++L E + + L+D V + + + LI
Sbjct: 1215 RVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN 1274
Query: 575 SLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMA 634
L + RLQ E L E KDAL++ +Q Q E + EEE + +A
Sbjct: 1275 DLTAQRARLQTEAGEYSRQLDE-KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA 1333
Query: 635 HDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLL 694
H L ++ R +C LRE+ + E++ K+ + + L + E R ++
Sbjct: 1334 HAL-----QSSRHDCDLLREQ--YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386
Query: 695 NQISLLKQNLEIQLSQSQTSLQQLQAQ---FTQERQRLTQELEEL---EEQHQQRHKSLK 748
++ K+ L +L +++ ++ + A+ + +QRL E+E+L E+ +L
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 749 EAHVLAFQTMEEEKEK-EQRALENHLQQKH----SAELQSLKDAHRESMEGFRI------ 797
+ + + E K+K E+ E QK S EL +K+ + ES++
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENK 1506
Query: 798 EMEQELQTLRFELEDEGKAM--LASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSI 855
++QE+ L ++ + GK + L ++ ++ + E+ AA E E S+
Sbjct: 1507 NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC------------EIQAALEEAEASL 1554
Query: 856 DISRRQSKEHICRI-TDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRI 914
+ + I RI +L + + I+E D+E+ L N + + + ++ +R
Sbjct: 1555 E----HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS 1610
Query: 915 RSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSL- 973
R+++ + + E DLN E E+ + A+ L +++ ++ T +LKE L +L
Sbjct: 1611 RNDALRVKKKMEGDLN---EMEIQLNHANRLAAESL--RNYRNTQGILKETQLHLDDALR 1665
Query: 974 --EEMEEKYLMRESKPEDIQM-ITELKAML--TERDQII--KKLIEDNKFYQL 1019
E+++E+ + E + +Q I EL A L TER + I ++L++ ++ QL
Sbjct: 1666 GQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Score = 131 bits (329), Expect = 4e-30
Identities = 214/1020 (20%), Positives = 429/1020 (42%), Gaps = 145/1020 (14%)
Query: 47 KIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRR 106
K+ LT+ + L+ + +AL++ H++ + + AE + + K+K L +
Sbjct: 977 KVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT----KLEQ 1032
Query: 107 KIQVLESSLEDHIKMKQQALTEFEAYKHRVE-DMQLCAEAQHVQRIVTMSREVEEIRRKF 165
++ LE SLE K++ + E K ++E D++L E+ + M + +++ K
Sbjct: 1033 QVDDLEGSLEQEKKLRM----DLERAKRKLEGDLKLAQES-----TMDMENDKQQLDEKL 1083
Query: 166 EEKLRSFGQLQVQFEKDKRLALE------DLQAAHRREIQELLKSQQDHSASVNKGQEKA 219
E+K L + E ++ + ++ +LQA I+EL + + AS K +++
Sbjct: 1084 EKKEFEISNLISKIEDEQAVEIQLQKKIKELQA----RIEELGEEIEAERASRAKAEKQR 1139
Query: 220 EELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQSFYERELDTLKRSQLFTAESLQ 278
+L R E+E +++ LEE +E LN K ++ +++ L+ + L +
Sbjct: 1140 SDLSR-ELEEISERLEEAGGATSAQVE-----LNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 279 ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ 338
A ++K AD E Q L++ KL+ E ++ E L + + A E +
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 339 VLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASD----LVLKASHIGMLQATQM 394
L+ Q+ + K E + + + ++L A R RLQ +A + L K + + L ++
Sbjct: 1254 SLEDQVSELKTKE----EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309
Query: 395 TQEVTIKD----LESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK 450
I++ LE E N L+ R + +EEQ+ + EL++ +++A
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK-AELQRALSKAN 1368
Query: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEEL--AWKHHMAIEAVHSNAIRDKKKL 508
++ + + R EE L EA K + L A +H A+ A ++ + K++L
Sbjct: 1369 SEVAQWRTKYETDAIQRTEE----LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 509 QMDLEE------------------QHNKDKLNLE----------------EDKNQLQQEL 534
Q ++E+ Q N DK+ E ++ L EL
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 535 ENLKEVLEDKLN----------TANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 584
+K V E+ L+ QEI L + + + + + E + ++ + +Q
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ 1544
Query: 585 NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTEN 644
L+ + SL+ + +L ++ EL Q + + + IA EE +D+ L+ T
Sbjct: 1545 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE----IDQ----LKRNHTRV 1596
Query: 645 LRQECSKLREELRLQHEEDK-KSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQN 703
+ S L E+R +++ + K M L + + N A + + + N +LK+
Sbjct: 1597 VETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKET 1656
Query: 704 LEIQLSQSQTSLQQLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 760
++ L + + L+ Q +R L E+EEL +Q +S K +A Q + +
Sbjct: 1657 -QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRK----IAEQELLD 1711
Query: 761 EKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAM--L 818
E+ Q L + L + K + + E+E+ +Q R E KA+
Sbjct: 1712 ASERVQ------LLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 819 ASLRSELNHQH--AAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----CRITDL 872
A + EL + +A ++ ++ N Q + + L+ + ++ + K+ I R+ +L
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1825
Query: 873 QEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKR 932
+ E+ + + +E K ++ + LT + E K +LR+ QDL +
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRL------------QDLVDK 1873
Query: 933 LEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQM 992
L+ ++ + A+ +K + LQ LEE EE+ + ES+ +++
Sbjct: 1874 LQAKVKSYKRQAEEAEEQSNANLSKFRK--------LQHELEEAEERADIAESQVNKLRV 1925
Score = 121 bits (304), Expect = 3e-27
Identities = 198/963 (20%), Positives = 416/963 (43%), Gaps = 155/963 (16%)
Query: 47 KIAQLTKVIYALNTKNDEHESAIQALK------DAHEEEIQQILAETREKILQY---KSK 97
K+ LTK L + D+ E +++ K + + +++ L +E + K +
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 98 VTEELDLRR-KIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVT--- 153
+ E+L+ + +I L S +ED ++ Q + + + R+E++ EA+ R
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 154 ---MSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE------DLQAAHRREIQELLKS 204
+SRE+EEI + EE + G Q E +K+ E DL+ A + +
Sbjct: 1139 RSDLSRELEEISERLEE---AGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195
Query: 205 QQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELD 264
++ H+ S+ + E+ + L R++ + L K EL++E L + E ++KA+ L+
Sbjct: 1196 RKKHADSMAELGEQIDNLQRVK-QKLEKEKSELKMETDDLSSNAEA-ISKAKG----NLE 1249
Query: 265 TLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ 324
+ RS L+ +E++ L + Q A L+ G+ +L DE +L+ +
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL----DEKDALVSQLS 1305
Query: 325 KLQTALAIAENNVQVLQKQLDDAKEGEMAL-------------LSKHKEVESELAAARER 371
+ + A + ++ L+ QL++ + + AL L + E E E A +R
Sbjct: 1306 RSKQA---STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1362
Query: 372 LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSL 431
+A+ V + A Q T+E LE K ++ +RL + EE + +K SL
Sbjct: 1363 ALSKANSEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 432 DEEQKQQILELEKKVNEAKRT---------QQEYYERELKNLQSRLEEEVTQLNEAHSKT 482
++ +++ E+E + + +R+ +Q +++ L + + EE +L EA K
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAEL-EASQKE 1476
Query: 483 LEELAWKHHMAIEAVHSNAI-------RDKKKLQMDLEE------QHNKDKLNLEEDKNQ 529
L+ + ++ V+ ++ R+ K LQ ++ + + K LE+ K Q
Sbjct: 1477 SRSLSTEL-FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQ 1535
Query: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDL 589
++QE ++ LE+ + E G + + + Q + IA + ++L+
Sbjct: 1536 VEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTR 1595
Query: 590 TKDSLKETKDALL-----------NVEGELEQERQQ--HEETIAA------MKEEEKLKV 630
++++ T DA + +EG+L + Q H +AA + LK
Sbjct: 1596 VVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKE 1655
Query: 631 DKMAHDLEIKWTENLRQECSKLREELRL-------------QHEEDKKSAMSQLLQLKDR 677
++ D ++ E+L+++ + + L Q E +K A +LL +R
Sbjct: 1656 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASER 1715
Query: 678 -----EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQ---------LQAQFT 723
+N + + +KK+E N +S L+ +E + +S+ + ++ + A+
Sbjct: 1716 VQLLHTQNTSLINTKKKLE---NDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL 1772
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQS 783
++ Q + LE +++ +Q K L+ A Q + +K+ + LE +++ E+++
Sbjct: 1773 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL-EGEVEN 1831
Query: 784 LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQE 843
+ + E+++G R + E+ ++ L ++ E++ K +L DL+ +
Sbjct: 1832 EQKRNAEAVKGLR-KHERRVKELTYQTEEDRKNVL------------RLQDLV-----DK 1873
Query: 844 LAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH-------HISELDKEVQHLHEN 896
L A +R + + QS ++ + LQ EL E +++L + + +H
Sbjct: 1874 LQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1933
Query: 897 ISA 899
ISA
Sbjct: 1934 ISA 1936
Score = 51.2 bits (121), Expect = 5e-06
Identities = 85/413 (20%), Positives = 174/413 (42%), Gaps = 78/413 (18%)
Query: 46 KKIAQLTKVIYALNTKNDEHESAIQALKDA--HEE--------EIQQILAETREKILQYK 95
K+I +L K+ + + E ++A++ + + HEE E+ Q+ +E KI +
Sbjct: 1524 KQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1583
Query: 96 SKVTE-ELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTM 154
++ + + + R ++ ++S+L+ I+ + AL + + + +M++ + H R+
Sbjct: 1584 EEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEI--QLNHANRLAAE 1641
Query: 155 SRE--------VEEIRRKFEEKLRSFGQLQVQF------------------------EKD 182
S ++E + ++ LR L+ Q E+
Sbjct: 1642 SLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERS 1701
Query: 183 KRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERK 242
+++A ++L A R +LL +Q + K E + EVE + + + K
Sbjct: 1702 RKIAEQELLDASERV--QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAK 1759
Query: 243 KLIED---YEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADL-----RKEFQGQ 294
K I D +L K Q L+ +K++ T + LQ ++ L +K+ Q
Sbjct: 1760 KAITDAAMMAEELKKEQDT-SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1818
Query: 295 EAILRKTIGKLKTELQMVQDEAGSLLDKCQK------------------LQTALAIAENN 336
EA +R+ G+++ E Q EA L K ++ LQ + +
Sbjct: 1819 EARVRELEGEVENE-QKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAK 1877
Query: 337 VQVLQKQLDDAKEGEMALLSKHKEVESELAAARER---LQQQASDLVLKASHI 386
V+ ++Q ++A+E A LSK ++++ EL A ER + Q + L +K+ +
Sbjct: 1878 VKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 154 bits (390), Expect = 4e-37
Identities = 210/954 (22%), Positives = 427/954 (44%), Gaps = 134/954 (14%)
Query: 41 HLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTE 100
H + ++++L ++ L +K E E ++A K E+E++++ + + + KS E
Sbjct: 1318 HHNLENEVSRLEDIMQHLKSKKRE-ERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
Query: 101 ELDLRRKIQ----------------VLESSLEDHIKMKQQALTEFEAYKHRV-------- 136
+L R +Q + E +E +K + + E E + +
Sbjct: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
Query: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR 196
E +L AEA+ + + + KF + RS Q + E+ +R A E A +
Sbjct: 1437 EADRLLAEAE--SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET--AVNLV 1492
Query: 197 EIQELLKSQQDHSASVNKGQEKAEELHR----------MEVESLNKMLEELRLERKKLIE 246
+ + L+S Q + + + + K EE+ + + + L+K E+L E +KL +
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
Query: 247 DYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQE---AILRKTIG 303
D E A+ + L LK S++ LQA + + L+ + Q+ A+L + +G
Sbjct: 1553 DIE----MAERNEDHHLQVLKESEVL----LQAKRAELEKLKSQVTSQQQEMAVLDRQLG 1604
Query: 304 KLKTELQMVQDEAGSLLDKCQKLQTALAIAE-------NNVQVLQKQLDDAKEGEMALLS 356
K EL ++Q GS++ LQ AL + E N+++ ++ L++ + L
Sbjct: 1605 HKKEELHLLQ---GSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV 1661
Query: 357 KHKEVESELAAARERLQQQASDL--VLK--ASHIGMLQATQMTQEVTIKDLESEKSRVNE 412
+ E +++L ++ ++++ +L VL+ + H L+ ++ +L+ K + ++
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQ 1721
Query: 413 RLSQLEEER-AFLRSKT-----QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS 466
R+S+LE+ + A L K Q + ++QK +I E +K++ E + + E E + LQS
Sbjct: 1722 RVSELEKTQVAVLEEKLELENLQQISQQQKGEI-EWQKQLLERDKREIERMTAESRALQS 1780
Query: 467 RLE---EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK---------KKLQMDLEE 514
+E +E L E ++LA + A ++ + +KLQ +L+
Sbjct: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD- 1839
Query: 515 QHNKDKLNLEEDKNQLQQELENLKEVL----------EDKLNTANQEIGHL---QDMV-- 559
Q N+DKL+L D + +QQ+L+ +E + +D LN A Q++ H QD++
Sbjct: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
Query: 560 --RKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEE 617
+ ++ + Q +E Q +L + ++ ++E K L+ E + Q Q+ E
Sbjct: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE-MMFQRLQKERE 1958
Query: 618 TIAAMKEEEKLKVDKMAHDLEIKWTEN---LRQECSKL---REELRLQHEEDK------K 665
+ + E K+ + + H LE + T+ L Q SK+ E +R EE++ K
Sbjct: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEK 2018
Query: 666 SAMSQLLQLKDREKNAARDSW-----QKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 720
+ QL +RE+ S QK+ + + SLL+ + +++ + L+
Sbjct: 2019 TLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKE 2078
Query: 721 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780
+R +L + L E ++++ K + ++A ++ E+ +R ++ Q ++
Sbjct: 2079 ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVA----QDNHERARRLMKELNQMQYEYT 2134
Query: 781 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 840
+ A+++ +E ++E+ ++TL+ E++DE + L +L L A +L N
Sbjct: 2135 ELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNE 2194
Query: 841 H--QELAAAKMEL---------ERSIDISRRQSKEHICRITDLQEELRHREHHI 883
+ EL + K L E ++ S+ + R L+E+LRHRE +
Sbjct: 2195 NLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRL 2248
Score = 100 bits (250), Expect = 6e-21
Identities = 156/681 (22%), Positives = 302/681 (44%), Gaps = 89/681 (13%)
Query: 178 QFEKDKRLALEDLQAAHRREIQELLKSQQDH-SASVNKGQEKAEELHRMEVESLN----- 231
+ E D++L + + + L+ ++ SA+ + E +E+ + E + L
Sbjct: 415 KMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEF 474
Query: 232 KMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEF 291
K LEE ++ KK+ E + L K S + ++ L++ L ++ K++ A +KE
Sbjct: 475 KQLEEA-IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEI 533
Query: 292 QGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGE 351
+ + + K M ++G + L I Q L+ +LD+
Sbjct: 534 KDLQIAIDSLDSKDPKHSHMKAQKSGK--------EQQLDIMNKQYQQLESRLDEILSRI 585
Query: 352 MALLSKHKEVESELA----AARERLQQQASDLVLKAS-HIGML--QATQMTQEVTIKDLE 404
+ K++E +L AA E L++ ++ ++G + QATQ E + L
Sbjct: 586 AKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC--RKLR 643
Query: 405 SEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA-------KRTQQEY- 456
EK + +RL+++E+ER L E ++++ ELE + E ++TQ +
Sbjct: 644 DEKETLLQRLTEVEQERDQLEIVAMDA-ENMRKELAELESALQEQHEVNASLQQTQGDLS 702
Query: 457 -YERELK---NLQ----SRLEEE---VTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
YE EL+ NL+ ++L+EE VT+L + L+ K A++ A +
Sbjct: 703 AYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762
Query: 506 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLE---DKLNTANQEIGHLQDMVRKS 562
+K Q + E H K K +L++D N L+Q+L++ + L D L + + ++ RK
Sbjct: 763 EKEQEN-SELHAKLK-HLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKL 820
Query: 563 EQGLGS------AEGLIASLQDSQERLQNELDLTKDSLKET--KDALLNVEGELEQER-- 612
+ G G ++ L SL D Q++ L +K E ++ L E L+QE+
Sbjct: 821 KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLA 880
Query: 613 --QQHEETIAAMKEEEKLKVDKMAHDLEIKWTEN----LRQECSKLRE-----ELRLQHE 661
Q+ E ++ DK H+ I+ EN L++ + E +L+LQ
Sbjct: 881 TGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEA 940
Query: 662 EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQ 721
+++K + L QL++ EK +KK+ED +Q + + E L++L+
Sbjct: 941 DEEKERI--LAQLRELEK-------KKKLEDAKSQEQVFGLDKE---------LKKLKKA 982
Query: 722 FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQ-QKHSAE 780
+ T EL ++Q + H ++ + + + ++E + ++A + + AE
Sbjct: 983 VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
Query: 781 LQSLKDAHRESMEGFRIEMEQ 801
++ L++ R+ E FR+EME+
Sbjct: 1043 IELLQNLLRQKGEQFRLEMEK 1063
Score = 94.7 bits (234), Expect = 4e-19
Identities = 205/1003 (20%), Positives = 416/1003 (41%), Gaps = 213/1003 (21%)
Query: 95 KSKVTEELDLRRKIQVLESSLEDHIKM----KQQALTEFEAYKHRVEDMQLCAEAQHVQR 150
K K E L+ K++VL S K+ K L E +++ ++ ++Q+
Sbjct: 114 KFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQK 173
Query: 151 IVTMSREVEEIRRKFEEKLRSFGQLQVQFEK-------DKRLALEDLQAA---------- 193
+ E+E I +KL+S L ++ K K L+DL +
Sbjct: 174 LNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTL 233
Query: 194 ---------HRREIQELLKSQQDHSASVNKGQEK--AEELHRMEVESLNKMLE--ELRLE 240
H R + E L+ Q + + E+ EE+ R+E + KM+E EL+ +
Sbjct: 234 PHYLQFTIFHLRSL-ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSK 292
Query: 241 RKKLIEDYEG--KLNKA---------QSFYERELDTLKRSQLFTAESLQASK--EKEADL 287
+ + +E+ + KLNK+ QS E + D +++L ++++ ++ +K+ +L
Sbjct: 293 QTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYEL 352
Query: 288 RKE---------------FQGQEAILRKT------IGKLKTELQMVQDEAGSLLDKCQKL 326
+E + + A + K IGK + + M E+ ++D Q +
Sbjct: 353 EQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATES-YIIDSAQAV 411
Query: 327 QTALAIAENNVQ----------VLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQA 376
Q + ++ L QL+D ++ A ++ E+ E+ A +++ +
Sbjct: 412 QIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT 471
Query: 377 SDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQK 436
+ I + + ++ +++ K L VN+ LR + L+ + +
Sbjct: 472 EEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNK-----------LRQEALDLELQME 520
Query: 437 QQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEA 496
+Q E+ K ++E+K+LQ ++ +L+ KH
Sbjct: 521 KQKQEIAGK------------QKEIKDLQIAID------------SLDSKDPKHS----- 551
Query: 497 VHSNAIRDKKKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHL 555
H A + K+ Q+D + +Q+ + + L+E +++ +E E +K+ LE++L
Sbjct: 552 -HMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD-LEEQLT--------- 600
Query: 556 QDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQER 612
+ + +E EG+I+ LQ+ ++ + ++ L++ K+ LL E+EQER
Sbjct: 601 EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
Query: 613 QQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQ-- 670
Q E I AM EN+R+E ++L L+ QHE + +Q
Sbjct: 661 DQLE--IVAMD------------------AENMRKELAELESALQEQHEVNASLQQTQGD 700
Query: 671 ----------LLQLKDREKNAARDSWQKKVEDLLNQISLLKQN-LEIQLSQSQTSLQQL- 718
L L+D E N ++ +K + +++ L+Q+ L+ +L + + +L+
Sbjct: 701 LSAYEAELEARLNLRDAEANQLKEELEK-----VTRLTQLEQSALQAELEKERQALKNAL 755
Query: 719 -QAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEE------KEKEQRALEN 771
+AQF++E+++ EL + +H Q +L + + FQ + +E A +
Sbjct: 756 GKAQFSEEKEQENSEL-HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVD 814
Query: 772 HLQQK-----HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELN 826
L++K + S D +S+ + + + L ++E DE + L+ E+
Sbjct: 815 ELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMA 873
Query: 827 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISEL 886
Q + L + A + LE ++ +RQ H RI ++ E+ + + ++ +
Sbjct: 874 LQQ----EKLATGQEEFRQACERALEARMNFDKRQ---HEARIQQMENEIHYLQENLKSM 926
Query: 887 D----------KEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +E E I A +ELE K K ++S +Q+ +++L K+L+K
Sbjct: 927 EEIQGLTDLQLQEADEEKERILAQLRELEKKKK---LEDAKSQEQVFGLDKEL-KKLKKA 982
Query: 937 LDVMTADHL--REKNIMRADFNKTNELLKEINAALQVSLEEME 977
V T+D L E I + + + +IN L+E E
Sbjct: 983 --VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAE 1023
Score = 93.2 bits (230), Expect = 1e-18
Identities = 144/694 (20%), Positives = 294/694 (42%), Gaps = 81/694 (11%)
Query: 402 DLESEKSRVNERLSQLE----EERAFLRSKTQSLDEEQK---------QQILELEKKVNE 448
+LE+E SR+ + + L+ EER SK QS E ++ Q+ LE +V E
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
Query: 449 AKRT------QQEYYERELKNLQSRLE--------EEVTQLNEAHSKTL----EELAWKH 490
RT Q+++ + +++L + LE E++ E KTL EL
Sbjct: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
Query: 491 HMAIEAVHS-NAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTAN 549
+ EA + ++K K ++ + L E D +ELE + L A+
Sbjct: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDA----EELERRAQETAVNLVKAD 1495
Query: 550 QEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELE 609
Q++ LQ + EQ E ++ + ++ ++ + L ++ ++E
Sbjct: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
Query: 610 QERQQHEETIAAMKEEEKLKVDKMAHDLEIK-WTENLRQECSKLREELRLQHEE------ 662
+ + + +KE E L K A ++K + +QE + L +L + EE
Sbjct: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
Query: 663 ---DKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQ 719
K+ + + L+L + E + + ++V+ LL ++S K L +Q+S+ +T L ++
Sbjct: 1616 SMVQAKADLQEALRLGETEVTE-KCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIK 1674
Query: 720 AQFTQERQRLT----------QELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL 769
+ +E + L EL+ + + Q + L+ + Q + E ++ + L
Sbjct: 1675 QEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVL 1734
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTL-RFELEDEGKAMLASLRSELNHQ 828
E L+ ++ LQ + + +E + +E++ + + R E S+
Sbjct: 1735 EEKLELEN---LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 829 HAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDK 888
D+ ++LA K R + + SK + L+ +R + + +L++
Sbjct: 1792 LQEKCDIWE----KKLAQTK----RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNR 1843
Query: 889 EVQHLHENISALTKELEFKGKEILRIRSE-SNQQ--IRLHEQDLNKRLEKELDVMTADHL 945
+ LH +ISA+ ++L+ K + + ++ E +N Q + L +QDL K DV+ ++
Sbjct: 1844 DKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL-LHTTKHQDVLLSEQT 1902
Query: 946 R-EKNIMR-----ADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAM 999
R +K+I D K E ++ LQ +EE + K + +E + +Q E +
Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEES 1962
Query: 1000 LTERDQIIKKLIEDNKFYQLELVNRETNFNKVFN 1033
E ++ K E + EL ++++ ++V +
Sbjct: 1963 KLETSKVTLK--EQQHQLEKELTDQKSKLDQVLS 1994
Score = 87.0 bits (214), Expect = 9e-17
Identities = 138/633 (21%), Positives = 276/633 (43%), Gaps = 76/633 (12%)
Query: 46 KKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQ------QILAETREKILQYKSKVT 99
K+I L I +L++K+ +H S ++A K E+++ Q L ++IL +K T
Sbjct: 531 KEIKDLQIAIDSLDSKDPKH-SHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
Query: 100 EELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE 159
EE+ LE+ + Q A E A K +E + + +++ I + + +
Sbjct: 590 EEI----------KDLEEQLTEGQIAANE--ALKKDLEGV-ISGLQEYLGTIKGQATQAQ 636
Query: 160 EIRRKFEEKLRSFGQLQVQFEKDK-RLALEDLQAAHRR----EIQELLKSQQDHSASVNK 214
RK ++ + Q + E+++ +L + + A + R E++ L+ Q + +AS+ +
Sbjct: 637 NECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQ 696
Query: 215 GQEKAEELHRMEVESLNKMLE----ELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS- 269
Q + E+E+ + + +L+ E +K+ + + + Q+ E+E LK +
Sbjct: 697 TQGDLSA-YEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNAL 755
Query: 270 --QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQD------EAGSLLD 321
F+ E Q + E A L K Q +L++ + + L V D E + +D
Sbjct: 756 GKAQFSEEKEQENSELHAKL-KHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVD 814
Query: 322 KCQKLQTALAIAENNVQ----VLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQAS 377
+ ++ + L E N+ VL K L D ++ +L++ K E A RER Q+
Sbjct: 815 ELRR-KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDE-AQVRERKLQEEM 872
Query: 378 DLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
L + G + Q + + +K + R+ Q+E E +L+ +S++E Q
Sbjct: 873 ALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGL 932
Query: 438 QILELEKKVNEAKR--TQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA-- 493
L+L++ E +R Q E++ K ++ +E+V L++ K + +A +A
Sbjct: 933 TDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATA 992
Query: 494 --------IEAVHSNAIRDKKKLQMDLEE--QHNKDKLNLEEDKNQLQQELENLKEVLED 543
++++H ++ ++ +L+E + ++ D + + E+E L+ +L
Sbjct: 993 ELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQ 1052
Query: 544 KLNTANQEIGHLQDMVRKSEQGLGSAEGL--IASLQDSQER-------LQNELDLTKDSL 594
K E+ K+ G G+ + I L ++ ER LQN LDLT
Sbjct: 1053 KGEQFRLEM-------EKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
Query: 595 KETKDALLNVEGELEQERQQHEETIAAMKEEEK 627
K + +L EL +E + I++M + K
Sbjct: 1106 KGGFENVLEEIAELRREVSYQNDYISSMADPFK 1138
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 154 bits (389), Expect = 5e-37
Identities = 219/1051 (20%), Positives = 466/1051 (44%), Gaps = 162/1051 (15%)
Query: 75 AHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKH 134
A ++E+++IL E ++++ EE D +++Q + + ++ L E EA +
Sbjct: 915 AKKQELEEILHE-------MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 135 RVEDMQLCAEAQ------HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE 188
+++ ++ AEA+ + + + ++ + R+ EE++ + E++K L
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNLT 1026
Query: 189 DLQAAHRREIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
L+ H I EL KS+Q+ K + A + H ++ L + EL+++
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1085
Query: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA--ESLQASKEKEADLRKEFQGQEAILR 299
K E+ + L + ++ + LK+ + LQ + E R + + Q+ L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
+ + LKTEL+ LD Q A E V VL+K LD+ A + +
Sbjct: 1146 EELEALKTELE-------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---Q 1195
Query: 360 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 419
E+ + A A E L +Q ++ L + T E DL E + + ++E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 420 ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH 479
++ L + Q+ EL+ K ++ +R + E ++ + LQ+ +E LNEA
Sbjct: 1253 KKKKLEA-----------QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAE 1300
Query: 480 SKTLEELAWKHHMAIE-AVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK 538
K ++ +A + A S+ ++D + +L ++ + KLN+ QL++E +L+
Sbjct: 1301 GKAIK-------LAKDVASLSSQLQDTQ----ELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 539 EVLEDKL---NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELD-LTK--- 591
+ L++++ + I L + S++ L + +L++ ++R Q E++ LT+
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 592 ------DSLKETKDALL----NVEGELEQERQ----------------QHEETIAAMKEE 625
D L++TK+ L ++ +L+ +RQ E+ I++ +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 626 EKLKVDKMAHDLEIKWTENLR--QECSKLREELRLQHEEDKKSAMSQLLQLKD------R 677
E+ + + A + E K R +E + +EEL + + K+ M L+ KD
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 678 EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 737
E ++ + + ++E++ Q+ + LE +L ++ + +L+ + + ++L+ +
Sbjct: 1529 ELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 738 EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 797
EQ++++ + L + + ++T E E E++QRAL ++K +L+ L+ +++G R
Sbjct: 1585 EQNEEKRRQL-QRQLHEYET-ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-RE 1641
Query: 798 EMEQELQTLRFELEDEGKAM--LASLRSEL------NHQHAAAIDLLRHNHHQELAAAKM 849
E ++L+ L+ +++D + + + R E+ N + A +++ ++LAAA+
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE- 1700
Query: 850 ELERSIDISRRQSKEHICRITD----LQEELRHREHHISELDKEVQHLHENISAL----- 900
+ D+ + + E + LQ+E R E I++L++E++ N+ A+
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 901 --TKELEFKGKEILRIRS------ESNQQIRLHEQDLNKRLEK----------------- 935
T++ E E+ RS + QQ+ ++L +L +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 936 ----ELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLE-EMEEKYLMRESKPEDI 990
+L+ REK + ++ LKEI LQV E +M E+Y +E +
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKMAEQY--KEQAEKGN 1876
Query: 991 QMITELKAMLTERDQIIKKLIEDNKFYQLEL 1021
+ +LK L E ++ +++ + + Q EL
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 143 bits (360), Expect = 1e-33
Identities = 212/991 (21%), Positives = 412/991 (41%), Gaps = 143/991 (14%)
Query: 139 MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 192
+Q+ + + +Q ++ +E ++K E +L+ Q Q ++K L E LQA
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 193 ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 236
A ++E++E+L + A + + +++ ++L ++ L + LEE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 237 LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 276
R+KL ++D KL+K + E + L +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1014
Query: 277 LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 335
L +EK +L K E+++ + +LK E + Q+ L+K +KL+ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1069
Query: 336 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 392
+ LQ Q+ + K M L K +E+++ LA + + Q+ + L HI LQ
Sbjct: 1070 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 449
++ E +K + E L L+ E T Q L +++Q++ L+K ++E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 450 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 508
R+ E +E++ ++ EE+T+ E + L K+ +E +++ + + L
Sbjct: 1187 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1244
Query: 509 QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 563
Q E +H K KL + + Q + + E + L DK++ E+ + M+ ++E
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 564 QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 614
+ L + LQD+QE LQ E + L+E +++L L+ E E +Q ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 615 HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
H T+ + K K+ A +E E ++ K E L Q+EE K +A +L
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1418
Query: 675 KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 732
++ KN + V DL NQ L+ + + + Q + + +++ ER R E
Sbjct: 1419 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 733 LEELE----------EQHQQRHKSLKEAHVLAFQTMEE-------------EKEKEQRAL 769
E E E+ + + L+ + + ME+ E EK +RAL
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQH 829
E +++ +L+ L+D ++ E ++ +E +Q L+ + E + +A R E N +
Sbjct: 1538 ETQMEEM-KTQLEELED-ELQATEDAKLRLEVNMQALKGQFERDLQA-----RDEQNEEK 1590
Query: 830 AAAIDLLRHNHHQEL----------AAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
+ H + EL AAAK +LE + Q+ I + ++LR
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 880 EHHISELDKEVQHL---HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ + + +E++ + I A KE E K K + + + + E R K+
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----RARKQ 1705
Query: 937 LDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITEL 996
D+ + E + N + + + A + EE+EE+ E+ + ++ T+
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 997 KAMLTERDQIIKKLIEDNKF--YQLELVNRE 1025
L+ + + N+ QLE N+E
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKE 1796
Score = 113 bits (282), Expect = 1e-24
Identities = 123/545 (22%), Positives = 259/545 (47%), Gaps = 67/545 (12%)
Query: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
K LQ+ +E+ + K + + + QQ+ EN + LE K + +E LQ+ ++ +
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
AE + L ++ L+ L + L+E +D ++ E ++ QQ + ++E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 625 EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 667
EE KL+++K+ + +IK E+ + + +KL +E +L E +++
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 668 MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
L +LK++ ++ + + KK E ++ LK+ LE S + LQAQ +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 726 RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 776
+ +L ++ EE L+++ Q++ +LK+ L ++E+ + E+ A +QK
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 777 H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 828
EL++LK ++++ R + EQE+ L+ L++E ++ A ++ E+ +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1200
Query: 829 HAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDK 888
HA A++ L Q AK L+++ +++ DL ELR + + +
Sbjct: 1201 HAQAVEELTEQLEQ-FKRAKANLDKNKQTLEKEN-------ADLAGELR----VLGQAKQ 1248
Query: 889 EVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREK 948
EV+H + + A +EL+ K + R R+E N ++ +L+ E++ +T
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH--------KLQNEVESVT------- 1293
Query: 949 NIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
++ K +L K++ A+L L++ +E L++E + + + T+L+ + ER+ +
Sbjct: 1294 GMLNEAEGKAIKLAKDV-ASLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 1009 KLIED 1013
+L E+
Sbjct: 1351 QLDEE 1355
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 154 bits (389), Expect = 5e-37
Identities = 219/1051 (20%), Positives = 466/1051 (44%), Gaps = 162/1051 (15%)
Query: 75 AHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKH 134
A ++E+++IL E ++++ EE D +++Q + + ++ L E EA +
Sbjct: 922 AKKQELEEILHE-------MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 135 RVEDMQLCAEAQ------HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE 188
+++ ++ AEA+ + + + ++ + R+ EE++ + E++K L
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNLT 1033
Query: 189 DLQAAHRREIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
L+ H I EL KS+Q+ K + A + H ++ L + EL+++
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1092
Query: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA--ESLQASKEKEADLRKEFQGQEAILR 299
K E+ + L + ++ + LK+ + LQ + E R + + Q+ L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
+ + LKTEL+ LD Q A E V VL+K LD+ A + +
Sbjct: 1153 EELEALKTELE-------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---Q 1202
Query: 360 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 419
E+ + A A E L +Q ++ L + T E DL E + + ++E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 420 ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH 479
++ L + Q+ EL+ K ++ +R + E ++ + LQ+ +E LNEA
Sbjct: 1260 KKKKLEA-----------QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAE 1307
Query: 480 SKTLEELAWKHHMAIE-AVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK 538
K ++ +A + A S+ ++D + +L ++ + KLN+ QL++E +L+
Sbjct: 1308 GKAIK-------LAKDVASLSSQLQDTQ----ELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 539 EVLEDKL---NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELD-LTK--- 591
+ L++++ + I L + S++ L + +L++ ++R Q E++ LT+
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 592 ------DSLKETKDALL----NVEGELEQERQ----------------QHEETIAAMKEE 625
D L++TK+ L ++ +L+ +RQ E+ I++ +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 626 EKLKVDKMAHDLEIKWTENLR--QECSKLREELRLQHEEDKKSAMSQLLQLKD------R 677
E+ + + A + E K R +E + +EEL + + K+ M L+ KD
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 678 EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 737
E ++ + + ++E++ Q+ + LE +L ++ + +L+ + + ++L+ +
Sbjct: 1536 ELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 738 EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 797
EQ++++ + L + + ++T E E E++QRAL ++K +L+ L+ +++G R
Sbjct: 1592 EQNEEKRRQL-QRQLHEYET-ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-RE 1648
Query: 798 EMEQELQTLRFELEDEGKAM--LASLRSEL------NHQHAAAIDLLRHNHHQELAAAKM 849
E ++L+ L+ +++D + + + R E+ N + A +++ ++LAAA+
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE- 1707
Query: 850 ELERSIDISRRQSKEHICRITD----LQEELRHREHHISELDKEVQHLHENISAL----- 900
+ D+ + + E + LQ+E R E I++L++E++ N+ A+
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 901 --TKELEFKGKEILRIRS------ESNQQIRLHEQDLNKRLEK----------------- 935
T++ E E+ RS + QQ+ ++L +L +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 936 ----ELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLE-EMEEKYLMRESKPEDI 990
+L+ REK + ++ LKEI LQV E +M E+Y +E +
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKMAEQY--KEQAEKGN 1883
Query: 991 QMITELKAMLTERDQIIKKLIEDNKFYQLEL 1021
+ +LK L E ++ +++ + + Q EL
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 143 bits (360), Expect = 1e-33
Identities = 212/991 (21%), Positives = 412/991 (41%), Gaps = 143/991 (14%)
Query: 139 MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 192
+Q+ + + +Q ++ +E ++K E +L+ Q Q ++K L E LQA
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 193 ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 236
A ++E++E+L + A + + +++ ++L ++ L + LEE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 237 LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 276
R+KL ++D KL+K + E + L +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1021
Query: 277 LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 335
L +EK +L K E+++ + +LK E + Q+ L+K +KL+ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1076
Query: 336 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 392
+ LQ Q+ + K M L K +E+++ LA + + Q+ + L HI LQ
Sbjct: 1077 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 449
++ E +K + E L L+ E T Q L +++Q++ L+K ++E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 450 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 508
R+ E +E++ ++ EE+T+ E + L K+ +E +++ + + L
Sbjct: 1194 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1251
Query: 509 QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 563
Q E +H K KL + + Q + + E + L DK++ E+ + M+ ++E
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 564 QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 614
+ L + LQD+QE LQ E + L+E +++L L+ E E +Q ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 615 HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
H T+ + K K+ A +E E ++ K E L Q+EE K +A +L
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1425
Query: 675 KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 732
++ KN + V DL NQ L+ + + + Q + + +++ ER R E
Sbjct: 1426 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 733 LEELE----------EQHQQRHKSLKEAHVLAFQTMEE-------------EKEKEQRAL 769
E E E+ + + L+ + + ME+ E EK +RAL
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQH 829
E +++ +L+ L+D ++ E ++ +E +Q L+ + E + +A R E N +
Sbjct: 1545 ETQMEEM-KTQLEELED-ELQATEDAKLRLEVNMQALKGQFERDLQA-----RDEQNEEK 1597
Query: 830 AAAIDLLRHNHHQEL----------AAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
+ H + EL AAAK +LE + Q+ I + ++LR
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 880 EHHISELDKEVQHL---HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ + + +E++ + I A KE E K K + + + + E R K+
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----RARKQ 1712
Query: 937 LDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITEL 996
D+ + E + N + + + A + EE+EE+ E+ + ++ T+
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 997 KAMLTERDQIIKKLIEDNKF--YQLELVNRE 1025
L+ + + N+ QLE N+E
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKE 1803
Score = 113 bits (282), Expect = 1e-24
Identities = 123/545 (22%), Positives = 259/545 (47%), Gaps = 67/545 (12%)
Query: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
K LQ+ +E+ + K + + + QQ+ EN + LE K + +E LQ+ ++ +
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
AE + L ++ L+ L + L+E +D ++ E ++ QQ + ++E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 625 EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 667
EE KL+++K+ + +IK E+ + + +KL +E +L E +++
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 668 MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
L +LK++ ++ + + KK E ++ LK+ LE S + LQAQ +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 726 RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 776
+ +L ++ EE L+++ Q++ +LK+ L ++E+ + E+ A +QK
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 777 H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 828
EL++LK ++++ R + EQE+ L+ L++E ++ A ++ E+ +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1207
Query: 829 HAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDK 888
HA A++ L Q AK L+++ +++ DL ELR + + +
Sbjct: 1208 HAQAVEELTEQLEQ-FKRAKANLDKNKQTLEKEN-------ADLAGELR----VLGQAKQ 1255
Query: 889 EVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREK 948
EV+H + + A +EL+ K + R R+E N ++ +L+ E++ +T
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH--------KLQNEVESVT------- 1300
Query: 949 NIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
++ K +L K++ A+L L++ +E L++E + + + T+L+ + ER+ +
Sbjct: 1301 GMLNEAEGKAIKLAKDV-ASLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 1009 KLIED 1013
+L E+
Sbjct: 1358 QLDEE 1362
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 154 bits (389), Expect = 5e-37
Identities = 219/1051 (20%), Positives = 466/1051 (44%), Gaps = 162/1051 (15%)
Query: 75 AHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKH 134
A ++E+++IL E ++++ EE D +++Q + + ++ L E EA +
Sbjct: 922 AKKQELEEILHE-------MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 135 RVEDMQLCAEAQ------HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE 188
+++ ++ AEA+ + + + ++ + R+ EE++ + E++K L
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNLT 1033
Query: 189 DLQAAHRREIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
L+ H I EL KS+Q+ K + A + H ++ L + EL+++
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1092
Query: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA--ESLQASKEKEADLRKEFQGQEAILR 299
K E+ + L + ++ + LK+ + LQ + E R + + Q+ L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
+ + LKTEL+ LD Q A E V VL+K LD+ A + +
Sbjct: 1153 EELEALKTELE-------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---Q 1202
Query: 360 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 419
E+ + A A E L +Q ++ L + T E DL E + + ++E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 420 ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH 479
++ L + Q+ EL+ K ++ +R + E ++ + LQ+ +E LNEA
Sbjct: 1260 KKKKLEA-----------QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAE 1307
Query: 480 SKTLEELAWKHHMAIE-AVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK 538
K ++ +A + A S+ ++D + +L ++ + KLN+ QL++E +L+
Sbjct: 1308 GKAIK-------LAKDVASLSSQLQDTQ----ELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 539 EVLEDKL---NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELD-LTK--- 591
+ L++++ + I L + S++ L + +L++ ++R Q E++ LT+
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 592 ------DSLKETKDALL----NVEGELEQERQ----------------QHEETIAAMKEE 625
D L++TK+ L ++ +L+ +RQ E+ I++ +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 626 EKLKVDKMAHDLEIKWTENLR--QECSKLREELRLQHEEDKKSAMSQLLQLKD------R 677
E+ + + A + E K R +E + +EEL + + K+ M L+ KD
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 678 EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 737
E ++ + + ++E++ Q+ + LE +L ++ + +L+ + + ++L+ +
Sbjct: 1536 ELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 738 EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 797
EQ++++ + L + + ++T E E E++QRAL ++K +L+ L+ +++G R
Sbjct: 1592 EQNEEKRRQL-QRQLHEYET-ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-RE 1648
Query: 798 EMEQELQTLRFELEDEGKAM--LASLRSEL------NHQHAAAIDLLRHNHHQELAAAKM 849
E ++L+ L+ +++D + + + R E+ N + A +++ ++LAAA+
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE- 1707
Query: 850 ELERSIDISRRQSKEHICRITD----LQEELRHREHHISELDKEVQHLHENISAL----- 900
+ D+ + + E + LQ+E R E I++L++E++ N+ A+
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 901 --TKELEFKGKEILRIRS------ESNQQIRLHEQDLNKRLEK----------------- 935
T++ E E+ RS + QQ+ ++L +L +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 936 ----ELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLE-EMEEKYLMRESKPEDI 990
+L+ REK + ++ LKEI LQV E +M E+Y +E +
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKMAEQY--KEQAEKGN 1883
Query: 991 QMITELKAMLTERDQIIKKLIEDNKFYQLEL 1021
+ +LK L E ++ +++ + + Q EL
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 143 bits (360), Expect = 1e-33
Identities = 212/991 (21%), Positives = 412/991 (41%), Gaps = 143/991 (14%)
Query: 139 MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 192
+Q+ + + +Q ++ +E ++K E +L+ Q Q ++K L E LQA
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 193 ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 236
A ++E++E+L + A + + +++ ++L ++ L + LEE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 237 LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 276
R+KL ++D KL+K + E + L +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1021
Query: 277 LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 335
L +EK +L K E+++ + +LK E + Q+ L+K +KL+ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1076
Query: 336 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 392
+ LQ Q+ + K M L K +E+++ LA + + Q+ + L HI LQ
Sbjct: 1077 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 449
++ E +K + E L L+ E T Q L +++Q++ L+K ++E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 450 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 508
R+ E +E++ ++ EE+T+ E + L K+ +E +++ + + L
Sbjct: 1194 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1251
Query: 509 QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 563
Q E +H K KL + + Q + + E + L DK++ E+ + M+ ++E
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 564 QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 614
+ L + LQD+QE LQ E + L+E +++L L+ E E +Q ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 615 HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
H T+ + K K+ A +E E ++ K E L Q+EE K +A +L
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1425
Query: 675 KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 732
++ KN + V DL NQ L+ + + + Q + + +++ ER R E
Sbjct: 1426 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 733 LEELE----------EQHQQRHKSLKEAHVLAFQTMEE-------------EKEKEQRAL 769
E E E+ + + L+ + + ME+ E EK +RAL
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQH 829
E +++ +L+ L+D ++ E ++ +E +Q L+ + E + +A R E N +
Sbjct: 1545 ETQMEEM-KTQLEELED-ELQATEDAKLRLEVNMQALKGQFERDLQA-----RDEQNEEK 1597
Query: 830 AAAIDLLRHNHHQEL----------AAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
+ H + EL AAAK +LE + Q+ I + ++LR
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 880 EHHISELDKEVQHL---HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ + + +E++ + I A KE E K K + + + + E R K+
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----RARKQ 1712
Query: 937 LDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITEL 996
D+ + E + N + + + A + EE+EE+ E+ + ++ T+
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 997 KAMLTERDQIIKKLIEDNKF--YQLELVNRE 1025
L+ + + N+ QLE N+E
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKE 1803
Score = 113 bits (282), Expect = 1e-24
Identities = 123/545 (22%), Positives = 259/545 (47%), Gaps = 67/545 (12%)
Query: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
K LQ+ +E+ + K + + + QQ+ EN + LE K + +E LQ+ ++ +
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
AE + L ++ L+ L + L+E +D ++ E ++ QQ + ++E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 625 EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 667
EE KL+++K+ + +IK E+ + + +KL +E +L E +++
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 668 MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
L +LK++ ++ + + KK E ++ LK+ LE S + LQAQ +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 726 RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 776
+ +L ++ EE L+++ Q++ +LK+ L ++E+ + E+ A +QK
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 777 H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 828
EL++LK ++++ R + EQE+ L+ L++E ++ A ++ E+ +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1207
Query: 829 HAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDK 888
HA A++ L Q AK L+++ +++ DL ELR + + +
Sbjct: 1208 HAQAVEELTEQLEQ-FKRAKANLDKNKQTLEKEN-------ADLAGELR----VLGQAKQ 1255
Query: 889 EVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREK 948
EV+H + + A +EL+ K + R R+E N ++ +L+ E++ +T
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH--------KLQNEVESVT------- 1300
Query: 949 NIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
++ K +L K++ A+L L++ +E L++E + + + T+L+ + ER+ +
Sbjct: 1301 GMLNEAEGKAIKLAKDV-ASLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 1009 KLIED 1013
+L E+
Sbjct: 1358 QLDEE 1362
Score = 49.3 bits (116), Expect = 2e-05
Identities = 78/379 (20%), Positives = 158/379 (41%), Gaps = 58/379 (15%)
Query: 35 DYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQY 94
D + + M Q + + A + +N+E +Q +E E++ E +++ L
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAA 1623
Query: 95 KSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR--IV 152
+K E DL+ LE + IK +++A+ + + +++D Q E R I
Sbjct: 1624 AAKKKLEGDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 153 TMSREVEEIRRKFEEKLRSF---------GQLQVQFEKDK-----------RLALEDLQA 192
++E E+ + E L + Q EK++ R AL+D +
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 193 ---AHRREIQELLKSQQDH----SASVNKGQEKAEELHR---------MEVESLNKMLEE 236
A +++E L+ +Q + S V K ++AE+L + ES + LE
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 237 LRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
E + + + EG + +S ++ + L+ E ++ ++ K + ++
Sbjct: 1800 QNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 297 ILRKTIGKLKTELQMV-----QDEAGSLLDKCQKLQTALAIAEN-----NVQVLQKQLDD 346
L++ + +++ E +M Q E G+ K K Q A E+ N + LQ++LD+
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 347 AKEGEMALLSKHKEVESEL 365
A E A+ + ++S+L
Sbjct: 1917 ATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 154 bits (389), Expect = 5e-37
Identities = 219/1051 (20%), Positives = 466/1051 (44%), Gaps = 162/1051 (15%)
Query: 75 AHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKH 134
A ++E+++IL E ++++ EE D +++Q + + ++ L E EA +
Sbjct: 915 AKKQELEEILHE-------MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 135 RVEDMQLCAEAQ------HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE 188
+++ ++ AEA+ + + + ++ + R+ EE++ + E++K L
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNLT 1026
Query: 189 DLQAAHRREIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
L+ H I EL KS+Q+ K + A + H ++ L + EL+++
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1085
Query: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA--ESLQASKEKEADLRKEFQGQEAILR 299
K E+ + L + ++ + LK+ + LQ + E R + + Q+ L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
+ + LKTEL+ LD Q A E V VL+K LD+ A + +
Sbjct: 1146 EELEALKTELE-------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---Q 1195
Query: 360 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 419
E+ + A A E L +Q ++ L + T E DL E + + ++E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 420 ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH 479
++ L + Q+ EL+ K ++ +R + E ++ + LQ+ +E LNEA
Sbjct: 1253 KKKKLEA-----------QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAE 1300
Query: 480 SKTLEELAWKHHMAIE-AVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK 538
K ++ +A + A S+ ++D + +L ++ + KLN+ QL++E +L+
Sbjct: 1301 GKAIK-------LAKDVASLSSQLQDTQ----ELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 539 EVLEDKL---NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELD-LTK--- 591
+ L++++ + I L + S++ L + +L++ ++R Q E++ LT+
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 592 ------DSLKETKDALL----NVEGELEQERQ----------------QHEETIAAMKEE 625
D L++TK+ L ++ +L+ +RQ E+ I++ +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 626 EKLKVDKMAHDLEIKWTENLR--QECSKLREELRLQHEEDKKSAMSQLLQLKD------R 677
E+ + + A + E K R +E + +EEL + + K+ M L+ KD
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 678 EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 737
E ++ + + ++E++ Q+ + LE +L ++ + +L+ + + ++L+ +
Sbjct: 1529 ELEKSKRALETQMEEMKTQL----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 738 EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 797
EQ++++ + L + + ++T E E E++QRAL ++K +L+ L+ +++G R
Sbjct: 1585 EQNEEKRRQL-QRQLHEYET-ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-RE 1641
Query: 798 EMEQELQTLRFELEDEGKAM--LASLRSEL------NHQHAAAIDLLRHNHHQELAAAKM 849
E ++L+ L+ +++D + + + R E+ N + A +++ ++LAAA+
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE- 1700
Query: 850 ELERSIDISRRQSKEHICRITD----LQEELRHREHHISELDKEVQHLHENISAL----- 900
+ D+ + + E + LQ+E R E I++L++E++ N+ A+
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 901 --TKELEFKGKEILRIRS------ESNQQIRLHEQDLNKRLEK----------------- 935
T++ E E+ RS + QQ+ ++L +L +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 936 ----ELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLE-EMEEKYLMRESKPEDI 990
+L+ REK + ++ LKEI LQV E +M E+Y +E +
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKMAEQY--KEQAEKGN 1876
Query: 991 QMITELKAMLTERDQIIKKLIEDNKFYQLEL 1021
+ +LK L E ++ +++ + + Q EL
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 143 bits (360), Expect = 1e-33
Identities = 212/991 (21%), Positives = 412/991 (41%), Gaps = 143/991 (14%)
Query: 139 MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 192
+Q+ + + +Q ++ +E ++K E +L+ Q Q ++K L E LQA
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 193 ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 236
A ++E++E+L + A + + +++ ++L ++ L + LEE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 237 LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 276
R+KL ++D KL+K + E + L +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1014
Query: 277 LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 335
L +EK +L K E+++ + +LK E + Q+ L+K +KL+ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1069
Query: 336 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 392
+ LQ Q+ + K M L K +E+++ LA + + Q+ + L HI LQ
Sbjct: 1070 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 449
++ E +K + E L L+ E T Q L +++Q++ L+K ++E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 450 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 508
R+ E +E++ ++ EE+T+ E + L K+ +E +++ + + L
Sbjct: 1187 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1244
Query: 509 QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 563
Q E +H K KL + + Q + + E + L DK++ E+ + M+ ++E
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 564 QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 614
+ L + LQD+QE LQ E + L+E +++L L+ E E +Q ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 615 HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
H T+ + K K+ A +E E ++ K E L Q+EE K +A +L
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1418
Query: 675 KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 732
++ KN + V DL NQ L+ + + + Q + + +++ ER R E
Sbjct: 1419 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 733 LEELE----------EQHQQRHKSLKEAHVLAFQTMEE-------------EKEKEQRAL 769
E E E+ + + L+ + + ME+ E EK +RAL
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Query: 770 ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQH 829
E +++ +L+ L+D ++ E ++ +E +Q L+ + E + +A R E N +
Sbjct: 1538 ETQMEEM-KTQLEELED-ELQATEDAKLRLEVNMQALKGQFERDLQA-----RDEQNEEK 1590
Query: 830 AAAIDLLRHNHHQEL----------AAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
+ H + EL AAAK +LE + Q+ I + ++LR
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 880 EHHISELDKEVQHL---HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ + + +E++ + I A KE E K K + + + + E R K+
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----RARKQ 1705
Query: 937 LDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITEL 996
D+ + E + N + + + A + EE+EE+ E+ + ++ T+
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 997 KAMLTERDQIIKKLIEDNKF--YQLELVNRE 1025
L+ + + N+ QLE N+E
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKE 1796
Score = 113 bits (282), Expect = 1e-24
Identities = 123/545 (22%), Positives = 259/545 (47%), Gaps = 67/545 (12%)
Query: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
K LQ+ +E+ + K + + + QQ+ EN + LE K + +E LQ+ ++ +
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
AE + L ++ L+ L + L+E +D ++ E ++ QQ + ++E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 625 EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 667
EE KL+++K+ + +IK E+ + + +KL +E +L E +++
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 668 MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
L +LK++ ++ + + KK E ++ LK+ LE S + LQAQ +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 726 RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 776
+ +L ++ EE L+++ Q++ +LK+ L ++E+ + E+ A +QK
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 777 H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 828
EL++LK ++++ R + EQE+ L+ L++E ++ A ++ E+ +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1200
Query: 829 HAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDK 888
HA A++ L Q AK L+++ +++ DL ELR + + +
Sbjct: 1201 HAQAVEELTEQLEQ-FKRAKANLDKNKQTLEKEN-------ADLAGELR----VLGQAKQ 1248
Query: 889 EVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREK 948
EV+H + + A +EL+ K + R R+E N ++ +L+ E++ +T
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH--------KLQNEVESVT------- 1293
Query: 949 NIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIK 1008
++ K +L K++ A+L L++ +E L++E + + + T+L+ + ER+ +
Sbjct: 1294 GMLNEAEGKAIKLAKDV-ASLSSQLQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 1009 KLIED 1013
+L E+
Sbjct: 1351 QLDEE 1355
Score = 49.3 bits (116), Expect = 2e-05
Identities = 78/379 (20%), Positives = 158/379 (41%), Gaps = 58/379 (15%)
Query: 35 DYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQY 94
D + + M Q + + A + +N+E +Q +E E++ E +++ L
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAA 1616
Query: 95 KSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR--IV 152
+K E DL+ LE + IK +++A+ + + +++D Q E R I
Sbjct: 1617 AAKKKLEGDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 153 TMSREVEEIRRKFEEKLRSF---------GQLQVQFEKDK-----------RLALEDLQA 192
++E E+ + E L + Q EK++ R AL+D +
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 193 ---AHRREIQELLKSQQDH----SASVNKGQEKAEELHR---------MEVESLNKMLEE 236
A +++E L+ +Q + S V K ++AE+L + ES + LE
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 237 LRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
E + + + EG + +S ++ + L+ E ++ ++ K + ++
Sbjct: 1793 QNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 297 ILRKTIGKLKTELQMV-----QDEAGSLLDKCQKLQTALAIAEN-----NVQVLQKQLDD 346
L++ + +++ E +M Q E G+ K K Q A E+ N + LQ++LD+
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 347 AKEGEMALLSKHKEVESEL 365
A E A+ + ++S+L
Sbjct: 1910 ATESNEAMGREVNALKSKL 1928
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 150 bits (378), Expect = 9e-36
Identities = 183/801 (22%), Positives = 375/801 (46%), Gaps = 110/801 (13%)
Query: 260 ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM-VQDEAGS 318
E+E+ T+K T E L S+ + +L ++ ++L++ K +LQ+ VQ E +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMV---SLLQE-----KNDLQLQVQSETEN 901
Query: 319 LLD---KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQ 375
L+D +C+ L + + E V+ L ++L++ +E L++K + +E + ++ L++
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS----LKRD 957
Query: 376 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLR-SKTQSLDEE 434
DL L + + + + E +K+L E + + E +S+L +E+ L+ + Q+LD+
Sbjct: 958 IDDLELTLTKV---EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014
Query: 435 QKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 494
Q + E KVN + + E++ +L+ LE+E
Sbjct: 1015 QVE-----EDKVNGLIKINAKL-EQQTDDLEGSLEQE----------------------- 1045
Query: 495 EAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ-------ELENLKEVLEDKLNT 547
+ + ++ R K+KL+ DL+ + ++LE DK Q+++ EL L+ ++D+
Sbjct: 1046 KKLRADLERAKRKLEGDLK-MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH 1104
Query: 548 ANQ---EIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA---- 600
+ Q +I LQ + + E+ + + L A ++ + L EL+ + L+E A
Sbjct: 1105 SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 601 ----------LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 650
+ +LE+ QHE T A +++++ V ++ ++ + ++Q+
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN--LQRVKQKLE 1222
Query: 651 KLREELRLQHEEDKKS--AMSQLLQLKDREKNAARDSWQK-KVED-----LLNQISLLKQ 702
K + EL+++ ++ + A+S+ +R D + + K +D L++ +++ K
Sbjct: 1223 KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKA 1282
Query: 703 NLEIQ---LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTME 759
L+ Q LS + L +Q T+ +Q LTQ+LEEL+ Q ++ K+ K A A Q+
Sbjct: 1283 RLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA-KNAMAHALQSSR 1341
Query: 760 EEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLA 819
+ + + E +Q+ AELQ + +R + E + ELE+ K +
Sbjct: 1342 HDCDLLREQYEE--EQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 820 SLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSI-DISRRQSKEHICRITDLQEELRH 878
L+ + A ++ L K L+ + D+ R + H T L ++ R+
Sbjct: 1400 RLQEAEENTETA------NSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT-LDKKQRN 1452
Query: 879 REHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHE--QDLNKRLEKE 936
+ ++E +++ + A KE E+ ++R+ + + E + NK L++E
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512
Query: 937 LDVMTADHLRE--KNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESK-----PED 989
+ +T + + E KN+ A+ KT +L+++ + LQV+LEE+E ESK E
Sbjct: 1513 ISDLT-EQIAETGKNLQEAE--KTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Query: 990 IQMITELKAMLTERDQIIKKL 1010
Q+ +EL + E+D+ I++L
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQL 1590
Score = 136 bits (342), Expect = 1e-31
Identities = 207/993 (20%), Positives = 434/993 (43%), Gaps = 135/993 (13%)
Query: 47 KIAQLTKVIYALNTKNDEHESAIQALK------DAHEEEIQQILAETREKILQY---KSK 97
K+ L K+ L + D+ E +++ K + + +++ L ++E I+ K +
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 98 VTEELDLRR-KIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVT--- 153
+ E+L + ++ L++ ++D Q + + + R+E+++ EA+H R
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 154 ---MSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSA 210
++RE+EEI + EE + G Q E +K+ E + RR+++E + +A
Sbjct: 1140 RSDLARELEEISERLEE---ASGATSAQIEMNKKREAEFQKM--RRDLEEATLQHEATAA 1194
Query: 211 SVNKGQ--------EKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERE 262
++ K Q E+ + L R++ + L K EL++E + + E L+K++S ER
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVK-QKLEKEKSELKMEIDDMASNIEA-LSKSKSNIERT 1252
Query: 263 LDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK 322
T++ ++A E++ L + Q+A L+ G+L ++ E SL+ +
Sbjct: 1253 CRTVEDQ----FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE----EKESLISQ 1304
Query: 323 CQKLQTALAIAENNVQVLQKQLDDAKEGEMA-------------LLSKHKEVESELAAAR 369
K + AL ++ L++Q+++ + + A LL + E E E A
Sbjct: 1305 LTKSKQALT---QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 370 ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQ 429
+R +A+ V + A Q T+E LE K ++ +RL + EE SK
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 430 SLDEEQKQQILELEKKVNEAKRT---------QQEYYERELKNLQSRLEEEVTQLNEAH- 479
SL++ +++ E+E + + +R+ +Q +++ L + +L+E +L A
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 480 -SKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQEL---- 534
S++L +K A E V +D E ++ NL+E+ + L +++
Sbjct: 1477 ESRSLSTELFKMRNAYEEV------------VDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 535 ENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL 594
+NL+E + K QE LQ + + E L E I +Q ++++ELD
Sbjct: 1525 KNLQEAEKTK-KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK---- 1579
Query: 595 KETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE 654
++ + E+EQ ++ + A++ ++ L +K + E
Sbjct: 1580 ------VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK----KKMEGDLNEM 1629
Query: 655 ELRLQHE-----EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQN---LEI 706
E++L H E +K + QLKD + + D + EDL Q++++++ L
Sbjct: 1630 EIQLGHSNRQMAETQKHLRTVQGQLKDSQLHL--DDALRSNEDLKEQLAIVERRNGLLLE 1687
Query: 707 QLSQSQTSLQQLQAQFTQERQRLT-QELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKE 765
+L + + +L+Q T+ +RL+ QEL + ++ Q H S + + + +E + +
Sbjct: 1688 ELEEMKVALEQ-----TERTRRLSEQELLDASDRVQLLH-SQNTSLINTKKKLEADIAQC 1741
Query: 766 QRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSEL 825
Q +EN +Q+ +AE ++ K +M ++ EQ+ ++ + + L+ L
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Query: 826 NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISE 885
+ A+ + Q+L ELE +D+ +++ E + + +++ + E
Sbjct: 1802 DEAEQLALKGGK-KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEE 1860
Query: 886 LDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHL 945
K + L + L +L+ K K R E+ +Q + +R++ EL+ +
Sbjct: 1861 DHKNILRLQD----LVDKLQAKVKSYKRQAEEAEEQANT-QLSRCRRVQHELE----EAA 1911
Query: 946 REKNIMRADFNKTNELLKEINAALQVSLEEMEE 978
+I + NK +++ + ++MEE
Sbjct: 1912 ERADIAESQVNKLRAKSRDVGS------QKMEE 1938
Score = 133 bits (334), Expect = 1e-30
Identities = 212/1000 (21%), Positives = 412/1000 (41%), Gaps = 106/1000 (10%)
Query: 59 NTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDH 118
NTK + L++ +E++ ++ T+ Y +V + + R+ D
Sbjct: 764 NTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERR---------DS 814
Query: 119 IKMKQQALTEFEAYKH--------RVEDMQLCAEAQHVQRIVTMSREVE---------EI 161
I Q + F KH +++ + AEA+ + + TM + E E
Sbjct: 815 IFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAE--KEMATMKEDFERTKEELARSEA 872
Query: 162 RRK-FEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAE 220
RRK EEK+ S Q + + + E+L A R + L+KS+ A V + E+ E
Sbjct: 873 RRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER-CEGLIKSKILLEAKVKELTERLE 931
Query: 221 ELHRMEVESLNKM--LEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQ 278
E M E + K LE+ K+ I+D E L K E+E + +E +
Sbjct: 932 EEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV----EKEKHATENKVKNLSEEMT 987
Query: 279 ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ 338
A +E + L KE + + ++T+ +LQ+ +D+ L+ KL+ E +++
Sbjct: 988 ALEENISKLTKEKKSLQEAHQQTLD----DLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 339 VLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEV 398
+K D + + L K + + QQ L K + LQA ++V
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Query: 399 TIKDLESEKSRVNERLSQLEEE---RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 455
+ + + R+ +LEEE LR+K + + +++ E+ +++ EA
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163
Query: 456 YYE----RELKNLQSRLE-EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 510
E RE + + R + EE T +EA + TL + + N R K+KL+
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE- 1222
Query: 511 DLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAE 570
K+K L+ + + + +E L + + T ++ K EQ
Sbjct: 1223 -------KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ----QT 1271
Query: 571 GLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
LI L + RLQ + ++E + + + + QQ EE M+EE K K
Sbjct: 1272 QLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAK- 1330
Query: 631 DKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKV 690
+ MAH L ++ R +C LRE+ + E++ K+ + + L + E R ++
Sbjct: 1331 NAMAHAL-----QSSRHDCDLLREQ--YEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 691 EDLLNQISLLKQNLEIQLSQSQTSLQQLQ---AQFTQERQRLTQELEELEEQHQQRHKSL 747
++ K+ L +L +++ + + A + +QRL E+E+L ++ H
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH--- 1440
Query: 748 KEAHVLAFQTMEEEKEKEQRALENHLQQ--KHSAELQSL-KDAHRESMEGFRI-----EM 799
A T+++++ + L Q+ + AEL++ K++ S E F++ E+
Sbjct: 1441 -----TACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 800 EQELQTLRFE---LEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAAAKMELERSI 855
+L+TLR E L++E + + + N Q A L +L A E+E S+
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 856 DISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIR 915
+ + ++ ++ EL + + E D+E++ L N + L+ +R R
Sbjct: 1556 EHEESKILRVQLELSQVKSEL---DRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 916 SESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEE 975
+++ + + E DLN E+++ R+ +T + L+ + L+ S
Sbjct: 1613 NDALRLKKKMEGDLN-----EMEIQLGHSNRQ-------MAETQKHLRTVQGQLKDSQLH 1660
Query: 976 MEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 1015
+++ E E + ++ +L E + +K +E +
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 149 bits (377), Expect = 1e-35
Identities = 232/1019 (22%), Positives = 435/1019 (42%), Gaps = 90/1019 (8%)
Query: 66 ESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
E Q ++ EEE Q E +E + + + ++ LRR+ Q+ E+ + +++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 126 LTEFEAYKHRVE--DMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK 183
+ E + + E + QL E Q +R + RE EE RR E++LR + + + ++ +
Sbjct: 322 REQQERREQQEERREQQLRRE-QEERREQQLRREQEEERR--EQQLRREQEEERREQQLR 378
Query: 184 RLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKK 243
R + RRE Q + Q + + Q+ E + L + EE R E+K
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 244 LIEDYEGKLNKAQ----SFYERELDTLKRSQLFTAESLQASKEKEADLRKE--FQGQEAI 297
E E +L + Q + +RE +T + Q + L+ +E+E R+E + +E
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE---RRERWLKLEEEE 495
Query: 298 LRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSK 357
R+ + + +L+ Q+E K Q+ + L + Q L+++ ++ +E ++ +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE-QLLKREE 554
Query: 358 HKEVESELAAAR-ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ 416
K +E E R +R Q++ D +LK Q + QE ++ + K ERL Q
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE--QRLKREEVERLEQ 612
Query: 417 LEEERAFLRSKTQSLDEEQKQQIL----ELEKKVNEAKRTQQEYYERELK--NLQSRLEE 470
EER R K + +EE++QQ+L + E++ + +R QQE E+ LK + RLE+
Sbjct: 613 --EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Query: 471 EVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ- 529
+ + +E + E + A E + S + + +L+ + + + +K + + Q
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERL------ 583
+QE E + E +L +E H Q + + + ++RL
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 584 --QNELDLTKDSLKETKDALLNVEGELEQERQQ---HEETIAAMKEEEKLKVDKMAHDL- 637
Q E L + ++ + L E E EQ R+Q E+ + ++EEE+L+ + A L
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 638 --------------------EIKWTENLRQECSKLREEL--------RLQHEEDKKSAMS 669
+ KW L +E + R L +L+ E+
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 670 QLLQLKDREKNAARD-SWQKKVEDLLNQ--ISLLKQNLEIQLSQSQTSLQQLQAQFTQER 726
+ LQ ++REK ++ Q + E+ L Q LL++ E + Q + + + Q+
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 727 QRLTQELEELEEQHQQRHKSLKEAHVL---AFQTMEEEKEKEQRALENHLQQKHSAELQS 783
++L E E + + Q+R K +E L Q + EE+EK +R +K Q
Sbjct: 971 EQLLGE-EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 784 LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQE 843
+ RE E R++ + EL+ E + +L R Q ++ +E
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER----QYRKEEE 1085
Query: 844 LAAAKMELER-SIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTK 902
L + +L R + RRQ +E CR +EEL+ E + ++E + E +
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCR---EEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 903 ELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELL 962
E E + +E +R E ++ R E + R E+EL LRE+ R E
Sbjct: 1143 EEEVQQEEEQLLREEPEKR-RRQELERQYREEEELQQEEEQLLREEQEKR-----RQERE 1196
Query: 963 KEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD-QIIKKLIEDNKFYQLE 1020
++ ++ ++ +++Y E + D++ E + RD ++ K E+ +F QLE
Sbjct: 1197 RQYREEEELQRQKRKQRY-RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Score = 145 bits (366), Expect = 2e-34
Identities = 209/973 (21%), Positives = 418/973 (42%), Gaps = 124/973 (12%)
Query: 72 LKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVL---ESSLEDHIKMKQQALTE 128
L+ EE QQ E ++++ Q + EE + R++ VL E L++ +Q+ L E
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEE----EEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 129 FEAYKHRVEDMQLCAEAQH-------VQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 181
E ++E +L E Q ++R + R+ EE RR+ +E+ R + + Q E+
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 182 DKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
+ L Q R Q+L + Q++ +E+ EE ++ ++ E +L R
Sbjct: 334 RREQQLRREQEERRE--QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKT 301
++ + E +L + Q RE + QL + L+ +E+E +K Q +
Sbjct: 392 EQQLR-REQQLRREQQL-RREQQLRREQQLRREQQLRREQEEERHEQKHEQERR------ 443
Query: 302 IGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEV 361
+ L+ Q+E L + + +T E Q L++ ++ + L
Sbjct: 444 ----EQRLKREQEERRDWLKR--EEETERHEQERRKQQLKRDQEEERRERWLKLE----- 492
Query: 362 ESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEER 421
E E +ER +QQ + + + +E +K E E+ R+ +RL ++ R
Sbjct: 493 EEERREQQERREQQ------------LRREQEERREQRLKRQE-EEERLQQRLRSEQQLR 539
Query: 422 AFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
+ + L + ++++ LE E++ KR Q+E ++ LK + R ++ +L +
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ---RLKREQEE 596
Query: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQEL-ENLKEV 540
LE+ + +E + R+++ + + EE+ + L EE + + QQ+L +E
Sbjct: 597 RLEQRLKREE--VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 541 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
E +L +E Q + R+ E+ E + ++ER+++ + + L+ DA
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 601 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 660
+ ++ ++ E ++EEK + + E++W E R R Q
Sbjct: 715 R---QSKVYSRPRKQEGQRRRQEQEEK----RRRRESELQWQEEERAH--------RQQQ 759
Query: 661 EEDKKSAMSQLLQLKDREKNAARD-SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQ 719
EE+++ RD +WQ + E+ + +Q L + + +QL+
Sbjct: 760 EEEQR-----------------RDFTWQWQAEE---KSERGRQRLSARPPLREQRERQLR 799
Query: 720 AQFTQER-QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHS 778
A+ Q+R QR E EE E++ +QR + KE Q +EEE++ ++R + +
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKE-----LQFLEEEEQLQRR--------ERA 846
Query: 779 AELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRH 838
+LQ +D +E E R + ++ Q R++LE+E K +L ++ A+
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK------PALQEQLR 900
Query: 839 NHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENIS 898
Q L + EL+R RR+ ++ R +E+L+ E + ++E + E
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 899 ALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMR------ 952
K+ + + KE ++ E ++ R E++ R E+EL LRE+ R
Sbjct: 959 QYRKDKKLQQKE-EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 953 ADFNKTNELLKEINAALQVS-----LEEMEEKYLMRESKPEDIQMITELKAMLTERDQII 1007
+ K +EL +E L+ L+E E +Y E ++ + + + R ++
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 1008 KKLIEDNKFYQLE 1020
++ ++ + Q E
Sbjct: 1078 RQYRKEEELQQEE 1090
Score = 137 bits (346), Expect = 4e-32
Identities = 217/1054 (20%), Positives = 441/1054 (41%), Gaps = 74/1054 (7%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAET 87
QL + +E LK+ ++ + + + ++ E Q LK EEE Q +
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 88 REKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQH 147
+++ + + + E+L R + + LE + ++Q + K E Q + +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 148 VQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQD 207
+R+ + EE+ R +E+ R + + E+++R L + R Q+L + QQ+
Sbjct: 595 EERLEQRLKR-EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 208 HSASVNKGQEKAEELH---RMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELD 264
K +E+ E L + E E + E E+++ E + ++ K Q E E D
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 265 TLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLL---- 320
++S++++ Q + + + ++ + +E+ L+ + Q +++
Sbjct: 714 A-RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 321 --DKCQKLQTALAIAENNVQVLQKQL--DDAKEGEMALLSKHKEVESELAAARERLQQQA 376
+K ++ + L+ + ++QL ++ ++ E L + +E E RER +++
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER-EKEL 831
Query: 377 SDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLS------QLEEERAFLRSKTQS 430
L + +A Q+ +E + E+ R E+ QLEEER R +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 431 LDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKH 490
Q+Q E + E + Q+E E+ + Q R E QL + + L E K
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 491 HMAIEAVHSNAIRDKKKLQM--------DLEEQHNKDKLNLEEDKNQLQQELEN-LKEVL 541
R KKLQ + E++ +++ ++ +LQQE E L+E
Sbjct: 952 R---RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 542 EDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDAL 601
E + + +D +++ E+ L E LQ+ + + + E + L++ ++ L
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE-----EELQQEEEQL 1063
Query: 602 LNVEGEL----EQERQQHEETIAAMKEEEKLKVD-----KMAHDLEIKWTENLRQECSK- 651
L E E E ERQ +E +EE+ L+ + + + + + E L+QE +
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 652 LREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 711
LREE + ++ + + +++ E+ R+ +K+ L + ++ E+Q +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER--QYREEEELQQEEE 1181
Query: 712 QTSLQQLQAQFTQERQRLTQELEELEEQ-HQQRHKSLKEAHVLAFQTMEEEKEKEQRALE 770
Q L++ Q + QER+R +E EEL+ Q +QR++ + L +Q E EKE R +
Sbjct: 1182 QL-LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ-WEPEKENAVRDNK 1239
Query: 771 NHLQQKHSAELQSLKDAH---RESME------GFRIEMEQELQTLRFELEDEGKAMLASL 821
+ + + + + + L+D+ R+S + G + E ++E + R++ D L
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 822 RSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH 881
E + A D Q L + E R + R+ +E ++ LR +E
Sbjct: 1300 ERE-EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 882 HISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMT 941
++E++H + L +E + +E R + QQ+R E++ R +++
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 942 ADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES--KPEDIQMITELKAM 999
+ + F + + QV +E E K+L E + E + E + +
Sbjct: 1419 EEQQLSRQERDRKFREEEQ---------QVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 1000 LTER-DQIIKKLIEDNKFYQLELVNRETNFNKVF 1032
L ER +Q + + D KF + E R ++ F
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Score = 135 bits (341), Expect = 2e-31
Identities = 219/1031 (21%), Positives = 441/1031 (42%), Gaps = 136/1031 (13%)
Query: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRK--------IQVLE 112
K++ + A E+ +Q+ AE R++ Q EE + RR+ +Q LE
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 113 SSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSF 172
E+ ++ +++A + + + +++ Q +Q +R ++EE R++ L +
Sbjct: 836 E--EEQLQRRERA-QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 173 GQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG-QEKAEELHRMEVESLN 231
LQ Q K+++L E+ + R E ++ + +Q+ + Q++ E+L R E E
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 232 KMLEELRLERKKLIEDYE----GKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADL 287
+ E + + K ++ E G+ + + ERE + +L E +E+E
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 288 RKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDA 347
R+E++ Q + K ELQ Q+E L ++ +K + + + +Q ++
Sbjct: 1013 RQEWERQY--------RKKDELQ--QEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 348 KEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEK 407
GE + +E+E + E LQQ+ L+ + E EK
Sbjct: 1063 LLGEERETRRRQELERQYRK-EEELQQEEEQLLRE---------------------EPEK 1100
Query: 408 SRVNERLSQLEEERAFLRSKTQSLDEE-QKQQILELEKKVNEAKRTQQEYYE-------- 458
R ER Q EE + + Q L EE +K++ ELE++ E + QQE +
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 459 RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 518
R + L+ + EE +L + + L E K E + R++++LQ +Q +
Sbjct: 1161 RRRQELERQYREE-EELQQEEEQLLREEQEKRRQERERQY----REEEELQRQKRKQRYR 1215
Query: 519 DKLNLEEDKNQLQQELENLKEVLEDKL---NTANQEIGHLQDMVRKSEQGLGSAEGLIAS 575
D+ + K Q + E EN V ++K+ N++ L+D + Q S
Sbjct: 1216 DEDQRSDLKWQWEPEKENA--VRDNKVYCKGRENEQFRQLEDSQLRDRQ----------S 1263
Query: 576 LQDSQERL--QNELDLTKDSLK-ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDK 632
QD Q L Q E D ++ + + +D E +LE+E Q+ + +EEK + +
Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 633 MAHDLEIKWTENLRQECS-KLREELRL----------QHEEDKKSAMSQL---------- 671
+ + RQE K REE +L + E D+K +L
Sbjct: 1324 EREE------KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 672 -----LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQER 726
L+ ++RE+ ++ Q + ++ Q+ ++ + + + Q S Q+ +F +E
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLR-QDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 727 QRLTQE------LEELEEQHQQRHKSLKEAHVLAFQTMEEE---KEKEQRALENHLQQKH 777
Q++ ++ LEE ++ Q+RH+ +E L + E++ +E++++ LE Q +
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 778 SAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLR 837
+ ++ S E R +E+E Q R + + + LR + Q +
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 838 HNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI 897
++L + E + S RQ ++ R+ + + + +E E D++ E
Sbjct: 1557 FREEEQLRQEREEQQLS-----RQERDRKFRLEEQKVRRQEQERKFME-DEQQLRRQEGQ 1610
Query: 898 SALTKELEFKGKEILRIRSESNQQIRLHEQDLNKR-LEKELDVMTADHLRE-KNIMRADF 955
L +E + K +E ++ E +Q +LH Q+ +++ LE+E + + ++ ++ F
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQ-QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 956 NKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 1015
+ +LL+E Q+ +E + K+ E + ++ + L E Q+ ++ +E K
Sbjct: 1670 REEEQLLQE-GEEQQLRRQERDRKFREEE---QQLRRQERERKFLQEEQQLRRQELE-RK 1724
Query: 1016 FYQLELVNRET 1026
F + E + +ET
Sbjct: 1725 FREEEQLRQET 1735
Score = 134 bits (338), Expect = 4e-31
Identities = 212/913 (23%), Positives = 397/913 (43%), Gaps = 116/913 (12%)
Query: 149 QRIVTMSREVEEI-----RRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK 203
+R R++EE R+K +E+ R + + Q EK +RL D Q R +EL +
Sbjct: 120 RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ----RRDEELWR 175
Query: 204 SQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIE-DYEGKLNKAQSFYERE 262
+Q+ + E+ E+L + + +E +L R++L+E +G+ K Q ER+
Sbjct: 176 QRQEWQEREERRAEE-EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 263 LDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK 322
++F E + +++E LRKE E L++ + + ELQ +++ L +
Sbjct: 235 ------DRVFQEEEEKEWRKRETVLRKE----EEKLQEEEPQRQRELQEEEEQLRKL--E 282
Query: 323 CQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLK 382
Q+L+ E Q L+++ ++ E + +E + E +ER +QQ +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQE----EERREQQEERREQQERREQQEER---R 335
Query: 383 ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQI 439
+ Q + Q++ ++ E E+ R Q EE R + Q L EQ ++Q
Sbjct: 336 EQQLRREQEERREQQLR-REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 440 LELEKKVN---EAKRTQQEYYERELKNLQS-RLEEEVTQLNEAHSKTLEELAWKHHMAI- 494
L E+++ + +R QQ E++L+ Q R E+E + + H + E K
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 495 --------EAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLN 546
E R K++L+ D EE+ + L LEE++ + QQE E +L
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR------EQQLR 508
Query: 547 TANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEG 606
QE Q + R+ E+ + Q+RL++E L ++ +E ++ LL E
Sbjct: 509 R-EQEERREQRLKRQEEE------------ERLQQRLRSEQQLRREQ-EERREQLLKREE 554
Query: 607 ELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKS 666
E E+++ E+ + +EE + D +K E RQ+ K +E RL+ + K+
Sbjct: 555 EKRLEQERREQRLKREQEERR--------DQLLKREEERRQQRLKREQEERLE-QRLKRE 605
Query: 667 AMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQER 726
+ +L Q + RE+ R+ +++ +Q L Q + QQL+ + + R
Sbjct: 606 EVERLEQEERREQRLKREEPEEE----------RRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 727 -QRLTQELEE--LEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQS 783
QRL +E EE LE++ ++ H+ + LA EEE+E+ + +++ + K +L+S
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELA----EEEQEQARERIKSRI-PKWQWQLES 710
Query: 784 LKDAHRESM-------EGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAA----- 831
DA + + EG R EQE + R E E + + + R + +
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 832 -AIDLLRHNHHQELAA---AKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELD 887
+ Q L+A + + ER + RQ +E R +EE R E +
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ--RFLPEEEEKEQRRRQRRERE 828
Query: 888 KEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLRE 947
KE+Q L E +E + +E E ++ R EQ +++ +L+ + R
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE---EERKRR 885
Query: 948 KNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQII 1007
++ + A +L KE LQ EE++ + + + E + E + + E +Q++
Sbjct: 886 RHTLYAKPALQEQLRKE-QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 1008 KKLIEDNKFYQLE 1020
++ E + + E
Sbjct: 945 REEREKRRRQERE 957
Score = 127 bits (319), Expect = 6e-29
Identities = 206/985 (20%), Positives = 403/985 (40%), Gaps = 146/985 (14%)
Query: 38 QEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQ----ILAETREK--- 90
+E + KK+ Q + + L + ++ + K EEE+QQ +L E REK
Sbjct: 956 RERQYRKDKKLQQKEEQL--LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 91 ------------ILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQ---QALTEFEAYKHR 135
+ Q + ++ E +R++Q E + +++Q Q L E + R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 136 VE-DMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAH 194
E + Q E + Q + RE E RR+ E + + + ++Q +++++L E+ +
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ-QEEEQLLREEREKRR 1132
Query: 195 RREIQELLKSQQDHSASVNKG-QEKAEELHRMEVESLNKMLEELRLERKKLI-EDYEGKL 252
R+E++ + +++ + +E+ E+ R E+E + EEL+ E ++L+ E+ E +
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 253 NKAQSFY--ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQ 310
+ + Y E EL KR Q + E ++ + + + KE ++ K K + Q
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD---NKVYCKGRENEQ 1249
Query: 311 MVQDEAGSLLDKC--QKLQTALAIAENNVQVLQK--------------QLDDAKEGEMAL 354
Q E L D+ Q LQ L + + ++ QL+ ++ E
Sbjct: 1250 FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR 1309
Query: 355 LSKHKEVESELAAAR--ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNE 412
+ + E +L E+ ++Q +D + Q Q +E ++ E ++ E
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEE----QLLQEREEQPLRRQERDRKFREE 1365
Query: 413 RLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELK---------- 462
L E+ R FL + + +E++++ L+ E+++ +R QQ +R+ K
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 463 ---NLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQH--- 516
+ + R EE+ + E K LEE + R++++L + EEQ
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEE-----EQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 517 -NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIAS 575
+D+ LEE++ +QE + ++ E +L + E L++ EQ L +
Sbjct: 1481 QERDRKFLEEEQQLRRQERD--RKFREQELRSQEPERKFLEE-----EQQLHRQQRQRKF 1533
Query: 576 LQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQH--------------EETIAA 621
LQ+ Q+ + E + ++ +D E +L QER++ E+ +
Sbjct: 1534 LQEEQQLRRQERGQQR---RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590
Query: 622 MKEEEKLKVD-------------KMAHDLEIKWTENLRQE-------------------- 648
++E K D + D + + E L QE
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650
Query: 649 -CSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQ 707
+ E +L+H+ D+K + L + E+ R +K + Q+ ++ +
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 708 LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQR 767
+ Q Q+L+ +F +E Q L QE E+ + + Q+R++ + E L + E++ +++R
Sbjct: 1711 QEEQQLRRQELERKFREEEQ-LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Query: 768 ----ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 823
E L+Q+ + +++ R+ E ++ E+E Q LR + D GK +
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD-GKYRWEEEQL 1828
Query: 824 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 883
+L Q + E A E R + Q +E R + E + RE HI
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR---QERERKLREEHI 1885
Query: 884 SELDKEVQHLHENISALTKELEFKG 908
KE Q H + + K E KG
Sbjct: 1886 RRQQKEEQR-HRQVGEI-KSQEGKG 1908
Score = 87.8 bits (216), Expect = 5e-17
Identities = 107/508 (21%), Positives = 216/508 (42%), Gaps = 25/508 (4%)
Query: 523 LEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER 582
L+E+K + + + +L+D+ +Q +D + E G + + +E
Sbjct: 95 LDEEK---RARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ---KRQEQEREL 148
Query: 583 LQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWT 642
+ E K E +D E EL ++RQ+ +E EEE+L+ K E
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDE-ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 643 ENLRQ-ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLK 701
E LR+ E +LR + R + ++ ++ ++ Q ++ ++ R++ +K E+ L + +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 702 QNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEE 761
Q +L + + L++L ERQ L +E +E EEQ QQR + ++ + E+
Sbjct: 268 QR---ELQEEEEQLRKL------ERQELRRERQE-EEQQQQRLRREQQLRRKQEEERREQ 317
Query: 762 KEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASL 821
+E+ + E QQ+ E Q ++ + R E E+E + + E E + L
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 822 RSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH 881
R E + + + ++ + +L R + R Q ++ QEE RH +
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 882 HISELDKEVQHL----HENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
H E ++ Q L E L +E E + E R + + + ++ +LE+E
Sbjct: 438 H--EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE- 494
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELK 997
+ RE+ + R + + LK ++ E+ L RE + Q++ +
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 998 AMLTERDQIIKKLIEDNKFYQLELVNRE 1025
E+++ ++L + + + +L+ RE
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKRE 582
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1910 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1955
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 2009
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2063
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2299
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2356 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2474 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2584
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2644
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2645 SFDGLRRK 2652
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1745 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1984 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2039
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2097
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2396
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQ 2599
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1564 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1673
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1969
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1970 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2144 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2198
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2199 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2377 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2432
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2613 EEVTASQVAATKTLPNGRDAL 2633
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 842 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 897
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 898 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 957 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1015
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1016 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1130
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1131 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1367
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1368 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1420 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1468
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1524
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1825 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1914 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1959
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 2013
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2067
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2303
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2359
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2360 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2478 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2588
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2589 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2648
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2649 SFDGLRRK 2656
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1748
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1749 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1988 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2043
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2101
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2400
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQ 2603
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1568 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1677
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1916
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1973
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1974 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2148 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2202
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2203 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2381 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2436
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2617 EEVTASQVAATKTLPNGRDAL 2637
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 846 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 901
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 902 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 960
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 961 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1019
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1020 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1134
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1135 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1194
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1195 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1254
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1255 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1314
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1315 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1371
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1372 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1424 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1472
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1528
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1829 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1884
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1910 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1955
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 2009
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2063
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2299
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2356 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2474 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2584
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2644
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2645 SFDGLRRK 2652
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1745 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1984 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2039
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2097
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2396
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQ 2599
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1564 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1673
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1969
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1970 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2144 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2198
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2199 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2377 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2432
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2613 EEVTASQVAATKTLPNGRDAL 2633
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 842 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 897
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 898 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 956
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 957 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1015
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1016 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1130
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1131 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1367
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1368 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1420 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1468
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1524
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1825 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1878 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1923
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 1977
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2031
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2211
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2267
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2323
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2324 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2442 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2552
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2553 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2612
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2613 SFDGLRRK 2620
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1653
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1713 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1952 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2007
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2065
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2364
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2544
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQ 2567
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1532 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1641
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1880
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1937
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1938 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2112 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2166
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2167 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2345 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2400
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2581 EEVTASQVAATKTLPNGRDAL 2601
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 810 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 865
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 866 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 924
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 925 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 983
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 984 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1098
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1099 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1158
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1159 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1218
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1219 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1278
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1279 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1335
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1336 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1388 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1436
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1492
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1793 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1848
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 2047 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 2092
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 2146
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2200
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2380
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2436
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2492
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2493 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2611 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2721
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2722 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2781
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2782 SFDGLRRK 2789
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1822
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1881
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1882 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 2121 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2176
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2234
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2533
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQ 2736
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1701 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1810
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 2049
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 2106
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 2107 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2281 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2335
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2336 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2514 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2569
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2750 EEVTASQVAATKTLPNGRDAL 2770
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 979 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 1034
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 1035 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 1093
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 1094 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1152
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1153 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1267
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1268 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1327
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1328 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1387
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1388 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1447
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1448 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1504
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1505 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1557 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1605
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1661
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1962 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 2017
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1888 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1933
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 1987
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2041
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2221
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2277
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2333
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2334 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2452 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2562
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2563 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2622
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2623 SFDGLRRK 2630
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1663
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1722
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1723 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1962 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2017
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2075
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2374
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2554
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQ 2577
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1542 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1651
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1890
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1947
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1948 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2122 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2176
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2177 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2355 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2410
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2591 EEVTASQVAATKTLPNGRDAL 2611
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 820 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 875
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 876 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 935 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 993
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 994 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1050 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1108
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1109 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1168
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1169 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1228
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1229 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1288
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1289 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1345
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1346 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1398 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1446
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1502
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1803 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1858
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1896 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1941
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 1995
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2049
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2229
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2285
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2341
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2342 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2459
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2460 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2570
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2571 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2630
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2631 SFDGLRRK 2638
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1671
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1730
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1731 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 1970 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2025
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2083
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2323
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2382
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2562
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQ 2585
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1550 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1659
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1718
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1898
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1955
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1956 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2130 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2184
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2185 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2363 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2418
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2599 EEVTASQVAATKTLPNGRDAL 2619
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 828 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 883
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 884 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 942
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 943 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1001
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1002 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1058 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1116
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1117 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1176
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1177 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1236
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1237 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1296
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1297 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1353
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1354 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1406 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1454
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1510
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1570
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1811 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1866
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 149 bits (377), Expect = 1e-35
Identities = 197/848 (23%), Positives = 377/848 (44%), Gaps = 83/848 (9%)
Query: 52 TKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTEELDLR 105
T+ AL K E+E + +D EE+ Q A+ E++ Q + EL+ +
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936
Query: 106 RKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKF 165
+ + +ED ++ ++Q E A K E A A + + E+ IR
Sbjct: 1937 KGL------VEDTLRQRRQVEEEILALKASFEK----AAAGKAE----LELELGRIRSNA 1982
Query: 166 EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM 225
E+ LRS Q +++ + ++LA E+ + RRE +E + Q+ +A +++ L
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE-- 2036
Query: 226 EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA 285
EVE L +EE R R++ ++ +L AQ ++ L +++ F A ++KE
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQ 2090
Query: 286 DLRKEFQGQEAILRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQK 342
+L++ Q ++++L + G+ + + ++ E + + + Q+ + AE Q ++
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 343 QLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQ 393
Q + + A KE E E A + Q+QA+D + K + + Q Q
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Query: 394 MTQEVT-----IKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKK 445
+ QE+T +++ + +K+ ++E L +L+ E + ++EE + Q+ EL K
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2270
Query: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
+ + R+ N Q L+EE ++ + EE A A EA + ++
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEE 2326
Query: 506 KKLQMD-LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSE 563
Q L E+ K+K+ ++ +L+ E E +L+ + A ++ LQ D + ++
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQ 2382
Query: 564 QGLGSAEGLIASLQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETI 619
Q +G +L+ ++R Q E+ + LK E A E + ++ R+Q EE
Sbjct: 2383 QLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 620 AAMKEEEKLKVDK--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKD 676
+ E +K + LEI+ ++ + +LRE + L+ E++K ++LLQLK
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
Query: 677 REKNAARDSWQKKVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
E + E LL + L+Q+ + L Q + ++Q +A+ Q Q +
Sbjct: 2501 EEMQTVQQ------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554
Query: 734 EELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESME 793
++L E+ Q++ + +++ +MEE + ++ A E ++ ELQ L+ R+ E
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QE 2611
Query: 794 GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELER 853
E Q L+ LE++ +A LA Q AA L + AA+ E E
Sbjct: 2612 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH 2671
Query: 854 SIDISRRQ 861
S D RR+
Sbjct: 2672 SFDGLRRK 2679
Score = 138 bits (347), Expect = 3e-32
Identities = 210/1043 (20%), Positives = 455/1043 (43%), Gaps = 107/1043 (10%)
Query: 68 AIQALKDAHEEEIQQILAETREKILQYKSKVTEE----LDLRRKIQVLESSLEDHIKMKQ 123
A++ + + E E+Q A EK Q + + EE LR + + + + ++
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 124 QALTEFEAYKHRV-EDMQLCAEAQHVQRIVTMSR-EVEEIRRKFEEKLRSFGQLQVQFEK 181
+A E E ++ + E ++L +A+ V + ++++ E E+ + + E + R G+ + Q +
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1712
Query: 182 DKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
+ LA ++L+ + Q+ L ++Q+ + E+ E+ ++ E L ++ E
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEELARLQREAA 1771
Query: 239 LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK---EADLRKEFQGQE 295
+K ++ E +L K ++ E L + R++ + + + SK++ EA +E +
Sbjct: 1772 AATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A LR + K + Q+ +++A + +++ A L+ + + A + + A
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 356 SKHKEVESELAAARERLQQQA----SDLVLKASHIGMLQATQM-TQEVTIKDLESEKSRV 410
+ + + + A R RL++QA +D+ + + + +++ Q+ ++D ++ +V
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 411 NERL--------------SQLEEERAFLRSKTQSLDEEQKQQILELEKK---VNEAKRTQ 453
E + ++LE E +RS + ++Q LE ++ E +R +
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 513
+E ER K+L + EEE + +A + +E L K A + A ++ + Q+ L
Sbjct: 2011 REAEERVQKSLAA--EEEAARQRKAALEEVERLKAKVEEA-RRLRERAEQESAR-QLQLA 2066
Query: 514 EQHNKDKLNLEEDKN--QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
++ + +L EE + +QQ+ + L++ L+ + + +Q G + R +E+
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEAR 2124
Query: 572 LIASLQDSQERLQ-NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+ A + +Q R Q E + K S +E A + E+ R++ E+ A + E+ +
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 631 -DKMAHDLEI----KWTENLRQECSKLREE---LRLQHEE---DKKSAMSQLLQLKDREK 679
K A D E+ K+ E ++ +++ +E LRLQ EE K +L +LK
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2244
Query: 680 NAARDSWQKK-----VEDLLNQISLLKQNLEIQ--------LSQSQTSLQ---QLQAQFT 723
AAR Q + V + ++S LK +E + +Q LQ + Q
Sbjct: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL-----------ENH 772
+E RL+ +E Q + L + LA + ++E+ + Q A +
Sbjct: 2305 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2364
Query: 773 LQQKHSAELQSLKDAH----RESMEGF----------RIEMEQELQTLRFELEDEGKAML 818
L Q+ + LQ K+ E +GF ++EM E + L+ + + +A
Sbjct: 2365 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ- 2423
Query: 819 ASLRSELNHQHAAAIDLLRHNHHQELAA-AKMELERSIDISRRQSKEHICRITDLQEELR 877
A + A ++ H ELA K+ L ++++I R+QS R+ + EL
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 878 HREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKEL 937
+ + + K +Q E + + +E + + L+ S + L + ++ + +L
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES----KPEDIQMI 993
+ + D + + +R + + + +++ L S+EE + E K E++Q +
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Query: 994 TELK----AMLTERDQIIKKLIE 1012
+ + +L E +Q +++ ++
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQ 2626
Score = 130 bits (328), Expect = 5e-30
Identities = 247/1101 (22%), Positives = 459/1101 (41%), Gaps = 153/1101 (13%)
Query: 28 QLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE- 86
Q+A + S E L+ SK+ + K + +EH + Q ++A QQ AE
Sbjct: 1591 QVALETAQRSAEAELQ-SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 87 ----TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLC 142
++ +++ K E L LR + + + +Q++L + EA K + E +
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVA---------QQKSLAQAEAEKQKEEAEREA 1700
Query: 143 AEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK---RLALEDLQAAHRREI- 198
+ RE+ E + + +L G Q + ++ RL E Q +R++
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAETEQGEQQRQLL 1759
Query: 199 -QELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLN-KAQ 256
+EL + Q++ +A+ K QE EL ++ E + + R E + + K +A+
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 257 SFYEREL-DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG------KLKTEL 309
+ REL + R + E+ + + E D ++ E +L + + +LKTE
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Query: 310 QMVQDEAGSLLDKCQKLQTALAIA---------------ENNVQVLQKQLDDAKEGEMAL 354
++ E + ++ ++L A E + L+K D E + L
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1939
Query: 355 ----LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE-SEKSR 409
L + ++VE E+ A + ++ A+ +G +++ E T++ E +E
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA---EDTLRSKEQAELEA 1996
Query: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS--R 467
+R EEER + EE+ Q+ L E++ ++ E ER ++ R
Sbjct: 1997 ARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
Query: 468 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-LQMDLE-EQHNKDKLN--- 522
L E Q + + +E A K A E H+ A++ K++ LQ L+ EQ D+L
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 523 ---------LEEDKNQLQ----------QELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
EE + Q + +E E LK+ E++ Q + + +++E
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
Query: 564 QGLGS-AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Q A+ A+L+ Q E++ K ++T VE EL R Q EET
Sbjct: 2171 QEAARRAQAEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2225
Query: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL---RLQHEEDKK-----SAMSQLLQL 674
+ +K +D+ L+ + TE RQ S++ EEL R+Q EE K A ++ L L
Sbjct: 2226 -DHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 675 KDREKNAA----RDSWQKKVEDLLNQISL-------LKQNLEIQLSQSQTSLQQL---QA 720
+D++ K+V + ++S+ L+Q E L+Q + +++ +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 721 QFTQERQRLTQELEELEEQH---QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK- 776
Q QE RL E E L++Q Q++ + L+E Q + EE + QR LE Q++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 777 -HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA--- 832
SAE + LK E M + E++ Q R + E+ G+ + R+EL Q
Sbjct: 2404 EMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLH---RTELATQEKVTLVQ 2459
Query: 833 ---IDLLRHNHHQE-LAAAKMELERSIDISRRQSK---------EHICRITDLQEELRHR 879
I + +H E L A ELER + ++++K + + + LQE +
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 880 EHHISELDKEVQH---LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKE 936
+ +SE D +Q + + + L + + + + ++R E +Q + EQ+ + +
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579
Query: 937 LDVMTADHLREKNIMRADFN---------KTNELLKEINAALQVSLEEMEEKYLMRESKP 987
+ H E+ + R + ELL E N L+ L+ +EE++ +
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639
Query: 988 EDI--QMITELKAMLTERDQI 1006
E++ + K + RD +
Sbjct: 2640 EEVTASQVAATKTLPNGRDAL 2660
Score = 117 bits (294), Expect = 5e-26
Identities = 233/1078 (21%), Positives = 445/1078 (41%), Gaps = 137/1078 (12%)
Query: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEE 101
L S A + V + + N E + A+ L+ H Q ++ + + KS + +
Sbjct: 869 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH----QALVTLWHQLHVDMKSLLAWQ 924
Query: 102 LDLRRKIQVLES-SLEDHIKMK----QQALTEFEA-YKHRVEDMQLCAEAQHVQRIV--- 152
LRR +Q++ S SL +K +QAL E Y+ + D Q R++
Sbjct: 925 -SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 983
Query: 153 ---TMSREVEEIRRKFEEKLRSFGQLQ--VQFEKDKRLALE--DLQAAHRREIQELLKSQ 205
+ S +++ + E+ + + Q + KD RL LE + + HR + L K
Sbjct: 984 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEP 1042
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
A Q+KA+ EVE L K + L E +K++ E E EL
Sbjct: 1043 ARECAQRIAEQQKAQA----EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098
Query: 266 LKRSQLFTAESLQASKEKEADLR-KEFQGQEAILRKTIGKLKTELQMVQ---DEAGSLLD 321
K Q+ + ++ K K L + QG E +LR +LK E Q V E +
Sbjct: 1099 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKA 1157
Query: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ--QASDL 379
+KL+ + L+ +L A+E L +H E + E+ RER+ Q +
Sbjct: 1158 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1217
Query: 380 VLKASHIGMLQATQMTQEVTI--KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ 437
VL + + + Q+ +++ + + + + + + E+ +A + +Q++ E+ +Q
Sbjct: 1218 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1277
Query: 438 QILELEK------KVNEAKRTQQEY------YERELKNLQSRLEEEVTQLNEAHSKTLEE 485
+ LE+ KV E +R ++Y YE +L +++LE + + ++ E
Sbjct: 1278 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1337
Query: 486 LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKL 545
+ ++ + +S + + E + + EE++ QQ E + + E +
Sbjct: 1338 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME---EEERLAEQQRAEERERLAEVEA 1394
Query: 546 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVE 605
Q + + Q AE ++ Q+R+Q E+ +++ + + +++
Sbjct: 1395 ALEKQ-----RQLAEAHAQAKAQAE---REAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 606 GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
EL+Q RQ E I A K + + A ++ E +R L+L+ E ++
Sbjct: 1447 EELQQLRQSSEAEIQA-----KARQAEAAERSRLRIEEEIRVV------RLQLEATERQR 1495
Query: 666 SAMS---QLLQLKDREKNAARDSWQKKVEDLLNQI---SLLKQNLEIQLSQSQTSLQQLQ 719
Q L+ + E A + Q++ E L Q+ S K+ E++L+ S + +
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVKAE 1551
Query: 720 AQFTQERQRLTQELEELEEQHQQRHKSLKEAHV-------LAFQTMEEEKEKEQRA---- 768
A+ +E+QR Q LEEL Q ++ + L++A V +A +T + E E ++
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1611
Query: 769 -------LENHLQQKHSAELQSLKDAHRESM-----EGFRIEMEQEL--------QTLRF 808
LE LQ++H A Q ++A R + E R E E+EL + LR
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 809 ELEDEGKAMLASL-RSELNHQHAAAIDLLRHNHHQELAA------AKMELERSIDISRRQ 861
L+ E A SL ++E Q A R E A A+ ELE+ ++
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 862 SKEHIC---RITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE- 917
+++ + + L+ E E L++E+ L +A T++ + E+ ++R+E
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791
Query: 918 ---------SNQQIRLHEQDLNKRLEKELDVM--TADHLREKNIMRADFNKTNELLKEIN 966
+ ++ R + +RLE E A+ + + + +L +E
Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851
Query: 967 AALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERD---QIIKKLIEDNKFYQLEL 1021
A + E + + L + E ++ TE + L E++ + +++L ED F + L
Sbjct: 1852 ARQRAEAERVLAEKL--AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1907
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 147 bits (371), Expect = 6e-35
Identities = 222/986 (22%), Positives = 429/986 (43%), Gaps = 161/986 (16%)
Query: 133 KHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQ------LQVQFEKDKRLA 186
K + ++ + + R+ + E R++ EEK+ S Q LQVQ E+D
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 187 LEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIE 246
E+ +L+K++ A V + E+ E+ M E K K+ +E
Sbjct: 901 AEE-------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAK---------KRKLE 944
Query: 247 DYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLK 306
D +L +R++D L+ + + A++ K +L +E G + I I KL
Sbjct: 945 DECSEL-------KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI----IAKLT 993
Query: 307 TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELA 366
E + +Q+ LD Q + + L++Q+DD EG L + K+V +L
Sbjct: 994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL-EGS---LEQEKKVRMDLE 1049
Query: 367 AARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERL-----------S 415
A+ +L+ DL ++TQE +I DLE++K +++ERL +
Sbjct: 1050 RAKRKLE---GDL-------------KLTQE-SIMDLENDKQQLDERLKKKDFELNALNA 1092
Query: 416 QLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYE-------RELKNLQSRL 468
++E+E+A L S+ Q +E + +I ELE+++ EA+RT + E REL+ + RL
Sbjct: 1093 RIEDEQA-LGSQLQKKLKELQARIEELEEEL-EAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 469 EE---------EVTQLNEAH----SKTLEELAWKHHMAIEAV---HSNAIRDK------- 505
EE E+ + EA + LEE +H A+ H++++ +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 506 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQG 565
++++ LE++ ++ KL L++ + ++Q ++ K LE T ++ + ++++
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKAEETQRS 1269
Query: 566 LGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEE 625
+ A LQ L +LD + + + L +LE ++Q EE + A
Sbjct: 1270 VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK--- 1326
Query: 626 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 685
+ +AH L+ + R +C LRE+ + E + K+ + ++L + E R
Sbjct: 1327 -----NALAHALQ-----SARHDCDLLREQY--EEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFT---QERQRLTQELEELE---EQ 739
++ ++ K+ L +L +++ +++ + A+ + + + RL E+E+L E+
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 740 HQQRHKSLKEAHVLAFQTMEEEKEK-EQRALENHLQQKH----SAELQSLKDAHRESMEG 794
+L + + + E K+K E+ E QK S EL LK+A+ ES+E
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 795 FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 854
++E + L+ E+ D L +L +L ++L A KMEL+ +
Sbjct: 1495 LET-FKRENKNLQEEISD--------LTEQLGSSGKTIHEL--EKVRKQLEAEKMELQSA 1543
Query: 855 IDISRRQSKEHICRITDLQEELRHR----EHHISELDKEVQHLHENISALTKELEFKGKE 910
++ + + +I Q E E ++E D+E++ N + L+
Sbjct: 1544 LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 911 ILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQ 970
R R+E+ + + E DLN E+++ L N M A+ K +K + + L+
Sbjct: 1604 ETRSRNEALRVKKKMEGDLN-----EMEI----QLSHANRMAAEAQKQ---VKSLQSLLK 1651
Query: 971 VSLEEMEEKYLMRESKPEDIQMITE----LKAMLTERDQIIKKLIEDNKFYQLELVNRET 1026
+ ++++ + E+I ++ L+A L E ++++ K + EL+ ET
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI--ET 1709
Query: 1027 NFNKVFNSSPTVGVINPLAKQKKKND 1052
+ S +IN QKKK D
Sbjct: 1710 SERVQLLHSQNTSLIN----QKKKMD 1731
Score = 127 bits (320), Expect = 5e-29
Identities = 203/921 (22%), Positives = 396/921 (42%), Gaps = 123/921 (13%)
Query: 47 KIAQLTKVIYALNTKNDEHESAIQALKDAH------EEEIQQILAETREKILQYKSKVTE 100
K+ LTK L + D+ E +++ K + +++ L T+E I+ ++ +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND-KQ 1074
Query: 101 ELDLRRK-----IQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVT-- 153
+LD R K + L + +ED + Q + + + R+E+++ EA+ R
Sbjct: 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEK 1134
Query: 154 ----MSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHS 209
+SRE+EEI + EE + G VQ E +K+ E + RR+++E + +
Sbjct: 1135 LRSDLSRELEEISERLEE---AGGATSVQIEMNKKREAEFQKM--RRDLEEATLQHEATA 1189
Query: 210 ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELD--TLK 267
A++ K H V L + ++ L+ ++KL K +S ++ ELD T
Sbjct: 1190 AALRKK-------HADSVAELGEQIDNLQRVKQKL--------EKEKSEFKLELDDVTSN 1234
Query: 268 RSQLFTAES-LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKL 326
Q+ A++ L+ D E + + ++++ L ++ +Q E G L + +
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 327 QTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHI 386
+ ++ +QL+D K +++E E+ A + + + A H
Sbjct: 1295 EALISQLTRGKLTYTQQLEDLK----------RQLEEEVKA-----KNALAHALQSARHD 1339
Query: 387 GMLQATQMTQEVTIK-DLESEKSRVNERLSQLEEE-RAFLRSKTQSLDEEQK---QQILE 441
L Q +E K +L+ S+ N ++Q + +T+ L+E +K Q++ E
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Query: 442 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNA 501
E+ V EA + E+ LQ+ +E+ + + ++ A A
Sbjct: 1400 AEEAV-EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN-------------AAAAALDKK 1445
Query: 502 IRDKKKLQMDLEEQHNKDKLNLEEDKNQ---LQQELENLKEVLEDKLN---TANQEIGHL 555
R+ K+ + ++++ + + LE + + L EL LK E+ L T +E +L
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1505
Query: 556 QDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEG-------EL 608
Q+ + + LGS+ I L+ +++L+ E + +L+E + +L + EG E
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1565
Query: 609 EQERQQHEETIAAMKEE-EKLKVD--KMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
Q + + E +A EE E+ K + ++ L+ R LR + +++ + ++
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Query: 666 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQ--FT 723
+QL + AA QK+V+ L SLLK + +IQL + + L+
Sbjct: 1626 E-----IQLSHANRMAAEA--QKQVKSLQ---SLLK-DTQIQLDDAVRANDDLKENIAIV 1674
Query: 724 QERQRLTQ-ELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQ 782
+ R L Q ELEEL +Q +S K LA Q + E E+ Q L + L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRK----LAEQELIETSERVQ------LLHSQNTSLI 1724
Query: 783 SLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAM--LASLRSELNHQH--AAAIDLLRH 838
+ K + + E+E+ +Q R E KA+ A + EL + +A ++ ++
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1784
Query: 839 NHHQELAAAKMELERSIDISRRQSKEHI----CRITDLQEELRHREHHISELDKEVQHLH 894
N Q + + L+ + I+ + K+ + R+ +L+ EL + +E K ++
Sbjct: 1785 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1844
Query: 895 ENISALTKELEFKGKEILRIR 915
I LT + E K +LR++
Sbjct: 1845 RRIKELTYQTEEDRKNLLRLQ 1865
Score = 91.3 bits (225), Expect = 5e-18
Identities = 128/633 (20%), Positives = 276/633 (43%), Gaps = 92/633 (14%)
Query: 27 AQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEE------I 80
+QL + Y+Q++ + +++ + K AL L++ +EEE +
Sbjct: 1299 SQLTRGKLTYTQQLE-DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1357
Query: 81 QQILAETREKILQYKSKV-------TEELD-LRRKIQVLESSLEDHIKMKQQALTEFEAY 132
Q++L++ ++ Q+++K TEEL+ ++K+ E+ ++ + E
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 133 KHR----VEDMQLCAEAQHVQRIVTMSRE------VEEIRRKFEEKLRSFGQLQVQFEKD 182
KHR +ED+ + E + ++ + E ++K+EE S +L+ ++
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE---SQSELESSQKEA 1474
Query: 183 KRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM-----EVESLNKMLE 235
+ L+ E L+ A+ ++ L ++++ + + E+L E+E + K LE
Sbjct: 1475 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLE 1534
Query: 236 ELRLERKKLIEDYE-------GKLNKAQSFY--------------ERELDTLKRSQLFTA 274
++E + +E+ E GK+ +AQ + + E++ KR+ L
Sbjct: 1535 AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVV 1594
Query: 275 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 334
+SLQ S + E R E + + + +++ +L A + + LQ+ L +
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654
Query: 335 NNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR------ERLQQQASDLVLKASHIGM 388
+ + DD KE + ++ +++EL R ER ++ A +++ S
Sbjct: 1655 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Query: 389 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 448
L +Q T L ++K +++ LSQL+ E + ++ +E+ K+ I + E
Sbjct: 1715 LLHSQNT------SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768
Query: 449 AKRTQ---------QEYYERELKNLQSRLEE----------EVTQLNEAHSKTLE-ELAW 488
K+ Q ++ E+ +K+LQ RL+E + Q EA + LE EL
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 489 KHHMAIEAVHSNAIRDKKKLQMDLE-EQHNKDKLNLEEDKNQLQQELENLK---EVLEDK 544
+ E+V +++ ++ + E+ K+ L L++ ++LQ +++ K E E++
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Query: 545 LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ 577
NT + +Q + ++E+ AE + L+
Sbjct: 1889 ANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 147 bits (371), Expect = 6e-35
Identities = 240/1144 (20%), Positives = 486/1144 (42%), Gaps = 222/1144 (19%)
Query: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQY-----KSKVTEELDLRRKIQVLESSL 115
+N S+ ++LK A E L E +EK+++ SK+ E + + K + L+
Sbjct: 1561 ENQSLSSSCESLKLALEG-----LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY 1615
Query: 116 EDHIKMKQQALTEFEAYKHRVEDMQ---------LCAEAQHVQRIVTMSREVEEIRRKFE 166
E ++ + E E +H VE ++ L + + + +E E+ + +
Sbjct: 1616 EILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
Query: 167 EKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQ---ELLKSQQDHSASVNKGQEKAEELH 223
EK+R F + + Q K L LE+ R E+ + K + S N ++ E
Sbjct: 1676 EKMRKFAKSKQQ----KILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 224 RMEVESLNKMLEELRLERKKLIEDY-------EGKLNKAQSFYE---------------- 260
+ME E+L+K + L E+ L E+ EG ++K +
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
Query: 261 ------RELDTLKRSQLFT-AESLQASKEKEADLRKEFQGQEAI---------LRKTIGK 304
E D+L S T +ES+ ++K + K+F + I L++ I
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
Query: 305 LKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQ------LDDAKEGEMALLSKH 358
L+ E Q ++ + +L ++ L + ++ + +++LQ++ L+ + E++ ++K
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
Query: 359 KEV-ESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL 417
KE E E ERL Q ++L IG ++ + LESE + + +S+L
Sbjct: 1912 KETAEEEKDDLEERLMNQLAEL---NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968
Query: 418 EEERAFLRSKTQSLDEEQKQQILE---------------------LEKKVNEAKRTQQE- 455
EEE+ L + ++ E +++ LE L++K E K+ Q++
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC 2028
Query: 456 --YYER-----------ELKNLQSRLEEEVTQLNEA----HSKTLEELAWKHHMAIEAVH 498
Y E+ E +S+ + E+T+ N A H K + + ++
Sbjct: 2029 IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088
Query: 499 SNAIR---DKKKLQMDL-------------------------EEQHNKDKLNLEEDKNQL 530
S A R D KL+ +L EE+H K+K N++E + L
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL 2148
Query: 531 QQELENLKEVLED---KLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 587
++E +L+E + + LN ++E+ LQ+ + + L + ++SLQD ++R+ +
Sbjct: 2149 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV---I 2205
Query: 588 DLTKDSLKETKDALLNVEGELEQER------QQHEETIAAMKEEEKLKVDKMAHDLEIKW 641
D K ++ DA+ + E E+ + + ++ EE K+ + ++ HD +I W
Sbjct: 2206 DEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI-W 2264
Query: 642 TENLRQE------------------CSKLREELRLQHEEDKKSAM--SQLLQLKDREKNA 681
+ E S+L E L H + A S+L LKD+ +
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
Query: 682 ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQ 741
+ +S +K E N +++Q E + S+ S +QL+ R+ LT L E +
Sbjct: 2325 S-NSLEKCKEQKGNLEGIIRQQ-EADIQNSKFSYEQLETDLQASRE-LTSRLHEEINMKE 2381
Query: 742 QRHKSL----KEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 797
Q+ SL +EA +A + ++ +KE + LEN L Q+ + L++ ++++++
Sbjct: 2382 QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI-VLEEENKKAVD---- 2436
Query: 798 EMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDI 857
+ Q ++TL+ +++ E N Q A +D + + +++ + + +R +
Sbjct: 2437 KTNQLMETLK------------TIKKE-NIQQKAQLD----SFVKSMSSLQNDRDRIVGD 2479
Query: 858 SRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE 917
++ + H+ I + + ++ ++L +E++ L ++ L E E+++ R +
Sbjct: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 918 SNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEME 977
NQ I + + + LE + L++ + + K E LKE A E++
Sbjct: 2540 LNQVITIKDSQQKQLLEVQ--------LQQNKELENKYAKLEEKLKESEEA----NEDLR 2587
Query: 978 EKY-LMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK--FYQLELVNRETNFNK---V 1031
+ ++E K + + I LK +++ + + L E+ Y +L +E ++ +
Sbjct: 2588 RSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL 2647
Query: 1032 FNSS 1035
F+SS
Sbjct: 2648 FSSS 2651
Score = 139 bits (350), Expect = 2e-32
Identities = 246/1127 (21%), Positives = 489/1127 (43%), Gaps = 160/1127 (14%)
Query: 8 WQQHYYGGSAAKFAPSPATAQLAGHSMDYSQ-EMHLKMSKKIAQLTKV---IYALNTKND 63
W H SA + S A + ++ + E+ LK+S ++LTK ++ L + +
Sbjct: 1288 WPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347
Query: 64 EHESAIQALK------DAHEEEIQQILAETREKI--LQYKSKVTEELDLRRKIQVLESSL 115
+ I++LK + H E +QQ L ++ +I L++ ++ +LD ++Q L S
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD---ELQKLISKK 1404
Query: 116 EDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQL 175
E+ + L+E EA +++ + E I + ++E ++ +E+++ QL
Sbjct: 1405 EEDVSYLSGQLSEKEAALTKIQTEIIEQE----DLIKALHTQLEMQAKEHDERIK---QL 1457
Query: 176 QVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLE 235
QV+ + K+ EI E +++Q + +A + R E NK L+
Sbjct: 1458 QVELCEMKQKP---------EEIGEESRAKQQIQRKL-----QAALISRKEALKENKSLQ 1503
Query: 236 ELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQE 295
E +L+ A+ ER L +S L ES +++ KE D G+
Sbjct: 1504 E--------------ELSLARGTIER----LTKS-LADVESQVSAQNKEKDT---VLGRL 1541
Query: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL 355
A+L++ KL TE+ E SL C+ L+ AL + + L K+++ K ++A
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601
Query: 356 SKHKEVESELAAARERLQQQASDLVLKASHIGML--QATQMTQEV--TIKDLESEKSRVN 411
++ +E EL E L Q ++ +A I + Q QE+ ++ E+ K
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 412 ERLSQLEEERAFLRSKTQSLDEEQKQQILELEK-------KVNEAKRTQQEYYERELKNL 464
++L + E+E ++ K + + ++Q+ILELE+ +V+ A T +E E L +
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 465 QSRLE--EEVTQLNEAHSKTLEELAWKHHMAIEAV----HSNAIRDKKKLQMDLEEQHNK 518
S E E V E SK + L + E V H K+ ++ E+H+
Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781
Query: 519 DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 578
EE + E E +D L+ + + +S SA ++
Sbjct: 1782 QTNVTEEGTQSIPGETEE-----QDSLSMST------RPTCSESVPSAKSANPAVSKDFS 1830
Query: 579 SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMA-HDL 637
S + + N L D LKE + G LE+E+Q+++E ++ E+ + +++ D
Sbjct: 1831 SHDEINNYLQQI-DQLKE------RIAG-LEEEKQKNKEFSQTLENEKNTLLSQISTKDG 1882
Query: 638 EIKW-----------TENLRQECS---KLREELRLQHEEDKKSAMSQLLQLKDREKNAAR 683
E+K + +++E S KL+E + ++ ++ M+QL +L N +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942
Query: 684 DSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQR 743
D ++++ L + + +NL+ +S+ + QQL + T+ + +E LE+ +
Sbjct: 1943 DVTDAQIKNELLESEM--KNLKKCVSELEEEKQQLVKEKTKVESEIRKEY--LEKIQGAQ 1998
Query: 744 HKSLKEAHVLAFQTMEEEKEKEQRALEN---HLQQKHSA---ELQSLKDAHRESMEGFRI 797
+ ++H Q + +EK++E + L+ Q+K SA +++L+ ES + I
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 798 EMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHN--------HHQELAAAKM 849
E Q + E + +A LAS + L+ + A +L N ++E ++M
Sbjct: 2059 TKENLAQAV--EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 850 ELERSIDISRR---QSKEHICRITDLQEELR-------HREHHISEL-------DKEVQH 892
+ ++ D+ RR ++H+ ++QE+L H E I E+ DKEVQ
Sbjct: 2117 K-QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 893 LHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMR 952
L EN+ + +L K + ++ + ++ I D K+ E++ E +
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQDDRDRVI-----DEAKKWERKFSDAIQSKEEEIRLKE 2230
Query: 953 ADFNKTNELLKEIN---AALQVSLEEMEEKYLMRESKPE-DIQMITEL-KAMLTERDQII 1007
+ + + L++++ L++++ +E + ESK + ++Q+ ++ + E +++
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL 2290
Query: 1008 KKLIEDNKFY---QLELVNRETNFNKVFNSSPTVGVINPLAKQKKKN 1051
+L E Y Q EL E+ + + + K++K N
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337
Score = 134 bits (336), Expect = 6e-31
Identities = 238/1123 (21%), Positives = 480/1123 (42%), Gaps = 192/1123 (17%)
Query: 45 SKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDL 104
+K+I+ L ++I D + SA AL EE Q+L++ +E S VTE L
Sbjct: 715 AKEISNLNQLIEEFKKNADNNSSAFTALS----EERDQLLSQVKEL-----SMVTE---L 762
Query: 105 RRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRK 164
R +++ LE +L + + ++ Y+ + L E H I S++V K
Sbjct: 763 RAQVKQLEMNLAEAERQRRLD------YESQTAHDNLLTEQIHSLSIEAKSKDV-----K 811
Query: 165 FEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHR 224
E +Q+QF + L + LQ+ + + E+L+ + +K +E ++ L +
Sbjct: 812 IEVLQNELDDVQLQFSEQSTL-IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 225 MEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK- 283
E+E + KM ++L LE+K+ +E + Q+ E++ + S T + +Q ++EK
Sbjct: 871 KELE-ITKM-DQLLLEKKRDVETLQ------QTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
Query: 284 ----EADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ- 338
E KE Q +L + K +++ + + L ++ A I++ +Q
Sbjct: 923 SLGVEIKTLKE---QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 979
Query: 339 ---VLQKQLDDAKEGEMALLSKHKEVESELAAARERL----QQQASDLVLKASHIGMLQA 391
+L+K+ + K A L KE+ ++ E L + ++ L + G ++
Sbjct: 980 EFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE 1039
Query: 392 TQMTQEVTIKDLESE--------KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELE 443
+ +E + K + S+ K ++E+ +L+ R L K + EEQ Q +++
Sbjct: 1040 DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA--EEQFQALVKQM 1097
Query: 444 KKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELA---------------- 487
+ + K Q + + E+ Q+ +++ +T +A L
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
Query: 488 WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNL---EEDKNQLQQELENLKEV---L 541
WK + + + ++K++LQ L+E K L +E + L++EL+ K+ L
Sbjct: 1158 WKPELEEKILALE--KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 542 EDKLNTANQEIGHLQDMVRKSE-QGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600
+++ + ++E ++ D +R+ + Q S +G + S D QE + L + K T+
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPST-DQQESCSSTPGLEEPLFKATEQH 1274
Query: 601 LLN--VEGELEQERQQHEETIAAMK----------EEEKLKVDKMAHDLEIKWTENLRQE 648
+E L + H E +A++ + ++++ +K+ +LE+K + +
Sbjct: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV--ELELKVSSTTSEL 1332
Query: 649 CSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEI-- 706
K E +LQ + +K+ + L+ E +S Q+K+E QI+ L+ E+
Sbjct: 1333 TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQP 1392
Query: 707 ---------------------QLSQSQTSLQQLQAQFTQER---QRLTQELEELEEQHQQ 742
QLS+ + +L ++Q + ++ + L +LE ++H +
Sbjct: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
Query: 743 RHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQE 802
R K L + + + EE +E RA + +Q+K A L S K+A +E+ +++E
Sbjct: 1453 RIKQL-QVELCEMKQKPEEIGEESRA-KQQIQRKLQAALISRKEALKENK-----SLQEE 1505
Query: 803 LQTLRFELEDEGKAMLASLRSELNHQH------AAAIDLLRHN-------------HHQE 843
L R +E K+ LA + S+++ Q+ + LL+ +Q
Sbjct: 1506 LSLARGTIERLTKS-LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564
Query: 844 LAAA----KMELERSIDISRRQSKE-------HICRITDLQEELRHRE------------ 880
L+++ K+ LE + + KE I T+ QE +H+E
Sbjct: 1565 LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--KHKELQKEYEILLQSY 1622
Query: 881 HHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVM 940
++S + +QH+ E + +EL K + + E+ +Q++ EQ++ + EK
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 941 TADHLR------EKNIMRADFNKTNELLKEI-------NAALQVSLEEMEEKYLMRESKP 987
+ + E + +RA+ + + KE NA+++ LE ++ +Y E+
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY---ETLS 1739
Query: 988 EDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNK 1030
+ Q + K L+E Q +K IE N Q L E + N+
Sbjct: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
Score = 129 bits (325), Expect = 1e-29
Identities = 225/1088 (20%), Positives = 462/1088 (42%), Gaps = 150/1088 (13%)
Query: 39 EMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETR---EKILQYK 95
E + M +++ + + I L + + + A QA + E+ + + R +++LQ
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQ-AEQAAQQVVREKDARFETQVRLHEDELLQLV 241
Query: 96 SKVTEELDLRRKIQVLESSLEDH----------IKMKQQALTEFEAYKHRVEDMQLCAEA 145
++ E ++++K++VL+ LE+H + + QQ LT E + EA
Sbjct: 242 TQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA 301
Query: 146 QHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQ 205
+H T+ E EE + E+ +L+V +++L+ +LQ +++ ++
Sbjct: 302 EHNTLRNTVETEREESKILLEKM-----ELEV---AERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 206 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 265
Q A + E+ H+ E+E + L+ ++L + D
Sbjct: 354 Q-AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL---------------QSACDA 397
Query: 266 LK--RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC 323
LK S+L ++ QA + + + E Q Q+ K I + L + Q E S
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK--SKEISQFLNRLPLQQHETASQTSFP 455
Query: 324 QKL-QTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLK 382
+ A+ E N+ LQK++ + + + ALL E+E EL A E+L Q + L+
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE-ELKAENEKLSSQIT-LLEA 513
Query: 383 ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQ----SLDEEQKQQ 438
+ G +A + E++I D+ +++S E Q E F + + L+ ++ Q+
Sbjct: 514 QNRTG--EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQE 571
Query: 439 ILELEKKVNEAKRTQQEYYE----RELKNLQSR----------LEE-------------- 470
+ K + KR ++ +E +E+K ++ LE+
Sbjct: 572 EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Query: 471 ----EVTQLNEAH-SKTLEELAWKHHMAIEAVHSNAIRDKKKLQM-DLEEQHNKDKLNLE 524
E Q + H S+T EE++ + +E + DK + D+ + H + L+
Sbjct: 632 LPAVEKEQASTEHQSRTSEEIS-LNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK 690
Query: 525 EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 584
+L+ +E+ E L+ +EI +L ++ + ++ + +L + +++L
Sbjct: 691 SQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLL 750
Query: 585 N---ELDLTKDSLKETKDALLNVEGELEQERQQHEETIA----AMKEEEKLKVDKMAHDL 637
+ EL + + + K +N+ Q R +E A ++ L ++ + D+
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810
Query: 638 EIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQ-----KKVED 692
+I+ +N ++++LQ E S QL+++E + + KVE+
Sbjct: 811 KIEVLQN-------ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 693 L---LNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH----- 744
L L+Q L ++ L + + ++ LQ ++ Q++T+ + E+ Q +
Sbjct: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Query: 745 -----KSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEM 799
K+LKE L + EE +KEQ +N + + A + S E E+
Sbjct: 924 LGVEIKTLKEQ--LNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE----EL 977
Query: 800 EQELQTLRFELEDEGKAMLASL--RSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDI 857
+ E L+ E E + + A+L R EL Q + ++ +ELA K E ++ I +
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKEL-LQRVSRLE-------EELANLKDESKKEIPL 1029
Query: 858 SR---------RQSKEHI--CRITDLQEELRHREHHISELDKEVQHLHENI-SALTKELE 905
S +++KE+ C + QE + + ISE + E+QH+ +++ L E +
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
Query: 906 FKG--KEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLK 963
F+ K++ + + QI L + ++++ ++T++ A +T +
Sbjct: 1090 FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149
Query: 964 EINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVN 1023
+ + E+EEK L E + E +Q +L+ LT R I+KK E + + EL
Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQLQ--KKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 1024 RETNFNKV 1031
++ ++N++
Sbjct: 1208 QKDDYNRL 1215
Score = 125 bits (314), Expect = 2e-28
Identities = 204/959 (21%), Positives = 406/959 (42%), Gaps = 163/959 (16%)
Query: 43 KMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEEL 102
K ++ KV L +N E S ++ + + Q LA+ ++ K ++T+
Sbjct: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS-QNELAKLESELKSLKDQLTDLS 2325
Query: 103 DLRRKIQVLESSLEDHIKMKQQALTEFE-AYKHRVEDMQLCAEAQHVQRIVTMSREVEEI 161
+ K + + +LE I+ ++ + + +Y+ D+Q E SR EEI
Sbjct: 2326 NSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT--------SRLHEEI 2377
Query: 162 RRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQEL-----------LKSQQDHSA 210
K E+K+ S L E+ ++A+ +L+ H +EI+EL + ++++
Sbjct: 2378 NMK-EQKIIS---LLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433
Query: 211 SVNKGQEKAEEL---------HRMEVESLNKMLEELRLERKKLIEDYEGK--------LN 253
+V+K + E L + +++S K + L+ +R +++ DY+ L
Sbjct: 2434 AVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 254 KAQSFYERELDTLK--------RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKL 305
K Q E + K RS + S A + E +E Q ++ + K
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
Query: 306 KTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVES-- 363
E+Q+ Q++ L +K KL+ L +E + L++ + +E + L KE+ES
Sbjct: 2554 LLEVQLQQNK--ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDL---SKEIESLK 2608
Query: 364 ----ELAAARERLQQQAS------DLVLKASHIGMLQATQMTQEVTIKDLESE------- 406
+L LQ++ + L +K + L A + + I +LE E
Sbjct: 2609 VSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
Query: 407 --------KSRVNERLSQLEEERAFLRSKTQSLDE---EQKQQILELEKKV------NEA 449
+ ++ + L L + +R++T++ +E E + ++E+E+K+ N+
Sbjct: 2669 AAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKG 2728
Query: 450 KRTQQEYYERELKNLQSRLE---EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKK 506
Q + + R + +LQ+ + EE+ +L + +L+ELA + +A+ +
Sbjct: 2729 LTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSET 2788
Query: 507 KLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 566
M+ E+++ L E L +L + ++++ HL + S +
Sbjct: 2789 AFSMNSTEENSLSHL-----------------EKLNQQLLSKDEQLLHLSSQLEDSYNQV 2831
Query: 567 GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE 626
S +ASLQ+ ++ L NEL+ + S +E K E Q ++ +++++ +
Sbjct: 2832 QSFSKAMASLQNERDHLWNELEKFRKS-EEGKQRSAAQPSTSPAEVQSLKKAMSSLQND- 2889
Query: 627 KLKVDKMAHDLEIKWTENLRQECSKLREEL--------RLQHEEDKKSAMSQLLQLKDRE 678
D +K +NL+Q+ ++ +E+ +LQ +DK A Q++Q + R+
Sbjct: 2890 --------RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF-QIMQEELRQ 2940
Query: 679 KNAARDSWQKKVEDLLNQIS-------LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQ 731
+N SWQ ++ L + S +K+ + +S L LQ +E + +
Sbjct: 2941 ENL---SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQ-NLIRELRSSSS 2996
Query: 732 ELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRES 791
+ + L+ Q+Q++ A Q + E E + L + L++ H EL+ +
Sbjct: 2997 QTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI------QQ 3050
Query: 792 MEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRH-----NHHQELAA 846
+ ++ +E TL +L D + SLR N QH DLL H QEL A
Sbjct: 3051 LNSNFSQLLEEKNTLSIQLCDTSQ----SLRE--NQQHYG--DLLNHCAVLEKQVQELQA 3102
Query: 847 AKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELE 905
+ ++ + Q K + R +D EELR + SE +++ + + ++ L K LE
Sbjct: 3103 GPLNID--VAPGAPQEKNGVHRKSD-PEELREPQQSFSEAQQQLCNTRQEVNELRKLLE 3158
Score = 120 bits (301), Expect = 7e-27
Identities = 216/1090 (19%), Positives = 473/1090 (43%), Gaps = 166/1090 (15%)
Query: 65 HESAIQALKDAHEEEIQQILAETREKILQYKSKVTE-ELDLRRKIQVLES---SLEDHIK 120
H+ + + +E++Q+ LA + +++ K + + ++ L++K + L+ + ++ IK
Sbjct: 35 HQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIK 94
Query: 121 -MKQQALTEFEAYKHRVEDMQ------LCAEAQHVQRIVTMSR-------EVEEIRRKFE 166
+K A + + +E+M+ L E Q +++ + E+E+I+ K +
Sbjct: 95 KLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQ 154
Query: 167 EKLRSFGQLQVQFEKD------------KRLALEDLQAAHRREIQELLKSQQDHSASVNK 214
EK LQ Q + + + Q + E L++Q + +
Sbjct: 155 EKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQA 214
Query: 215 GQEKAEE----------LHRMEVESL-------NKMLEELRLERKKLIEDYEGKLNKAQ- 256
Q+ E LH E+ L +M ++LR+ ++KL E E + +AQ
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 257 -SFYERELDTLKRSQLFTAESLQASKEKEADLRK----EFQGQEAILRK---TIGKLKTE 308
++EL ++ ++ LQ + + LR E + + +L K + + K
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334
Query: 309 LQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAA 368
+Q+E LL++ ++ A A E+ L+++ E + + + ++ EL +A
Sbjct: 335 FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA 394
Query: 369 RERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL-------EEER 421
+ L+ Q S L+ + QA Q Q TI+ LE + + ++ +SQ + E
Sbjct: 395 CDALKDQNSKLLQDKNE----QAVQSAQ--TIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 422 AFLRS-------KTQSLDEEQ----KQQILELEKKVNEAKRTQQEYYERELKNLQSRLEE 470
A S TQ++ EE +++++ELE + + E ELK +L
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL--EELKAENEKLSS 506
Query: 471 EVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE----QHNKDKLNLEED 526
++T L EA ++T E ++I + + ++ D+ E Q +K+ L +
Sbjct: 507 QITLL-EAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565
Query: 527 KNQLQQELENLKEVLEDK-LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQN 585
+ Q+E+ LK L+ K A+ E+ ++M + +G+ + + L+D+ +
Sbjct: 566 MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK-MKVFLEDTGQDF-- 622
Query: 586 ELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 645
+ N E L ++ T + E++ ++ +E+K T+
Sbjct: 623 -------------PLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAG--VELKSTKQD 667
Query: 646 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLE 705
+ ++ H+++ + SQ+L+L + + A++ ++K +++ +IS L Q +E
Sbjct: 668 GDKSLSAVPDIGQCHQDELERLKSQILEL-ELNFHKAQEIYEKNLDEKAKEISNLNQLIE 726
Query: 706 IQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKE 765
+ ++ + ++ER +L +++EL + R A V + E E+
Sbjct: 727 -EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELR------AQVKQLEMNLAEAER- 778
Query: 766 QRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED------EGKAMLA 819
QR L+ Q H L + H S+E + +++ L+ EL+D E ++
Sbjct: 779 QRRLDYESQTAHDNLL--TEQIHSLSIEA--KSKDVKIEVLQNELDDVQLQFSEQSTLIR 834
Query: 820 SLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR 879
SL+S+L ++ + ++ ER IS ++ +L + L +
Sbjct: 835 SLQSQLQNKESEVLE---------------GAERVRHIS--------SKVEELSQALSQK 871
Query: 880 EHHISELDKEVQHLHENISALTKELEFKGKEILRIR-SESNQQIRLHEQDLN-----KRL 933
E I+++D+ + ++ L + +E K +++ I S + + ++L+E+ + K L
Sbjct: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 934 EKELDVMTADHLREKNIMRADFNKTNELLK----EINAALQVSLEEMEEKYLMRESKPED 989
+++L++++ +K + D N+ + LK E++ A Q+S EE++ ++ + K E+
Sbjct: 932 KEQLNLLSRAEEAKKEQVEED-NEVSSGLKQNYDEMSPAGQISKEELQHEFDL--LKKEN 988
Query: 990 IQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTV-GVINPLAKQK 1048
Q +L+A L R ++++++ + EL N + K S T G + + K
Sbjct: 989 EQRKRKLQAALINRKELLQRVSR----LEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
Query: 1049 KKNDKSPTNR 1058
+ ++K T++
Sbjct: 1045 EYSEKCVTSK 1054
Score = 89.0 bits (219), Expect = 2e-17
Identities = 149/734 (20%), Positives = 320/734 (43%), Gaps = 103/734 (14%)
Query: 404 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKN 463
ES+ N ++E A+ L + +Q+ ++L++K +EA + +++ + ++K
Sbjct: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK-DEALQEERKAADNKIKK 95
Query: 464 LQSRLEEEVTQLNEAHSKTLEELAWKHHMAI----EAVHSNAIRDKKKLQMDLEEQHNKD 519
L+ + ++T LN K +EE+ + + ++ + DK + ++E + K
Sbjct: 96 LKLHAKAKLTSLN----KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151
Query: 520 KLNLEEDK-NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 578
KL +E+ + LQ +L + + +T +E ++ +++ E+ + + + ++ Q
Sbjct: 152 KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ- 210
Query: 579 SQERLQNELDLTKDSLKETK-----DALL------NVEGELEQER-------QQHEETIA 620
E+ ++ KD+ ET+ D LL +VE E++Q+ ++HEE++
Sbjct: 211 -AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLV 269
Query: 621 AMKE-----EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLK 675
+ +++L + + + + + + E + LR + + EE K + + ++L+
Sbjct: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEKMELE 327
Query: 676 DREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQER-------QR 728
E+ + + Q+++ LL Q Q + +L ++L+Q +E+ Q+
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQ-AQAELESRYSALEQKHKAEMEEKTSHILSLQK 386
Query: 729 LTQELEE------------LEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK 776
QEL+ L+++++Q +S + L Q ++ KE Q LQQ
Sbjct: 387 TGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQH 446
Query: 777 HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLAS------LRSELNHQHA 830
+A S D + E + E LQ ELE+E A+L S L++E N + +
Sbjct: 447 ETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE-NEKLS 505
Query: 831 AAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH-HISELDKE 889
+ I LL + A ++ +DI+ ++S D+ E ++H +S L E
Sbjct: 506 SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565
Query: 890 VQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLR--E 947
++ E I+ L +L+ +GK R E D +KE+ M + + +
Sbjct: 566 MKEAQEEIAFL--KLQLQGK-------------RAEEADHEVLDQKEMKQMEGEGIAPIK 610
Query: 948 KNIMRADFNKTNELLKEINAAL-QVSLEEMEEKYLMRESKPEDIQMI---TELKAMLTER 1003
+ D + L+ ++L V E+ ++ R S E+I + ELK+ +
Sbjct: 611 MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTS--EEISLNDAGVELKSTKQDG 668
Query: 1004 DQIIKKLIEDNKFYQLEL-------VNRETNFNK--------VFNSSPTVGVINPLAKQK 1048
D+ + + + + +Q EL + E NF+K + + + +N L ++
Sbjct: 669 DKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF 728
Query: 1049 KKNDKSPTNRFVSV 1062
KKN + ++ F ++
Sbjct: 729 KKNADNNSSAFTAL 742
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 146 bits (369), Expect = 1e-34
Identities = 215/1015 (21%), Positives = 440/1015 (43%), Gaps = 135/1015 (13%)
Query: 47 KIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRR 106
K+ LT+ + L+ + +AL++AH++ + + AE + K+K+ L +
Sbjct: 980 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI----KLEQ 1035
Query: 107 KIQVLESSLEDHIKMKQQALTEFEAYKHRVE-DMQLCAEAQHVQRIVTMSREVEEIRRKF 165
++ LE SLE K++ + E K ++E D++L E+ I+ + E +++ K
Sbjct: 1036 QVDDLEGSLEQEKKLRM----DLERAKRKLEGDLKLAQES-----IMDIENEKQQLDEKL 1086
Query: 166 EEKLRSFGQLQVQFEKDKRLALE------DLQAAHRREIQELLKSQQDHSASVNKGQEKA 219
++K LQ + E ++ L ++ +LQA I+EL + + AS K +++
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQA----RIEELEEEIEAERASRAKAEKQR 1142
Query: 220 EELHRMEVESLNKMLE----------ELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
+L R E+E +++ LE E+ +R+ + L +A +E TL++
Sbjct: 1143 SDLSR-ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 270 QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTA 329
+ L + ++++ + +++ ++ I L + ++ V G+L C+ L+
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 330 LAIAENNVQVLQKQLDD---------AKEGEMALLSKHKE-VESELAAARERLQQQASDL 379
L+ ++ + Q+ ++D + GE + KE + S+L+ ++ QQ +L
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 380 ------VLKASH--IGMLQATQMTQEVTIKDLESE---KSRVNERLSQLEEERAFLRSKT 428
+KA + LQ+++ ++ + E E K+ + LS+ E A R+K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYE------RELKNLQSRLEEEVTQLNEAHSKT 482
++ ++ +++ E +KK+ + + +E+ E L+ + RL+ EV L +T
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 483 LEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEED----------KNQLQQ 532
A A++ N + + + EE H + + + +E KN ++
Sbjct: 1442 NAACA-----ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 533 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 592
L+ L E L+ + QEI L + + + + + E + ++ + LQ L+ +
Sbjct: 1497 SLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555
Query: 593 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKL 652
SL+ + +L ++ EL Q + + + IA EE +D++ + I+ E+++ S L
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE----IDQLKRN-HIRIVESMQ---STL 1607
Query: 653 REELRLQHEEDK-KSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 711
E+R +++ + K M L + + N A + + + N +LK + +I L +
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDA 1666
Query: 712 QTSLQQLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 768
S + L+ Q +R L E+EEL +Q +S K A +E + +R
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE-------QELLDASERV 1719
Query: 769 LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAM--LASLRSELN 826
H Q + + M+G EME LQ R E KA+ A + EL
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQG---EMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 827 HQH--AAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----CRITDLQEELRHRE 880
+ +A ++ ++ N Q + ++ L+ + ++ + K+ I R+ +L+ E+ +
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 881 HHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLE---KEL 937
+E K ++ + LT + E K ILR+ QDL +L+ K
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL------------QDLVDKLQAKVKSY 1884
Query: 938 DVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQM 992
+ + N A F K LQ LEE EE+ + ES+ +++
Sbjct: 1885 KRQAEEAEEQSNTNLAKFRK-----------LQHELEEAEERADIAESQVNKLRV 1928
Score = 143 bits (361), Expect = 8e-34
Identities = 219/1017 (21%), Positives = 437/1017 (42%), Gaps = 143/1017 (14%)
Query: 72 LKDAHEEEIQQILAETREKILQYKSKVTEE--LDLRRKIQVLESSLEDHIKMKQQALTEF 129
L++ ++++ Q++ T+ + + ++V + ++ R I ++ ++ + +K +
Sbjct: 779 LEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKL 838
Query: 130 -----EAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKL------RSFGQLQVQ 178
K + ++ + Q+I + E R++ EEK+ ++ QLQVQ
Sbjct: 839 FFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898
Query: 179 FEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVE--SLNKMLEE 236
E E L A R +L+K++ A + + E+AE+ + E + + LE+
Sbjct: 899 AEA------EGLADAEER-CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951
Query: 237 LRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
E KK I+D E L K E+E + E + E A L KE + +
Sbjct: 952 ECSELKKDIDDLELTLAKV----EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 297 ILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLS 356
++T+ L+ E DK L A E V L+ L+ K+ M L
Sbjct: 1008 AHQQTLDDLQAEE-----------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER 1056
Query: 357 KHKEVESELAAARERL-------QQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR 409
+++E +L A+E + QQ L K I LQ+ ++ L+ +
Sbjct: 1057 AKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKE 1116
Query: 410 VNERLSQLEEE---RAFLRSKTQSLDEEQKQQILELEKKVNE------AKRTQQEYYERE 460
+ R+ +LEEE R+K + + +++ E+ +++ E A+ + E E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176
Query: 461 LKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDK 520
+ ++ LEE Q H T L KH ++ + + + K
Sbjct: 1177 FQKMRRDLEEATLQ----HEATAATLRKKHADSVAELGEQI------------DNLQRVK 1220
Query: 521 LNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQ 580
LE++K++++ E+++L +E T ++ G+L+ M R E L + S ++ Q
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVE----TVSKAKGNLEKMCRTLEDQLSE----LKSKEEEQ 1272
Query: 581 ERLQNELDLTKDSLK----------ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
+RL N+L + L+ + K+AL++ +Q Q E + EEE
Sbjct: 1273 QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 631 DKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKV 690
+ +AH L ++ R +C LRE+ + E++ K+ + + L + E R ++
Sbjct: 1333 NALAHAL-----QSSRHDCDLLREQ--YEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 691 EDLLNQISLLKQNLEIQLSQSQTSLQQLQAQ---FTQERQRLTQELEEL---EEQHQQRH 744
++ K+ L +L ++ ++ + A+ + +QRL E+E+L E+
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 745 KSLKEAHVLAFQTMEEEKEK-EQRALENHLQQKHS----AELQSLKDAHRESMEGFRI-- 797
+L + + + E K+K E+ E QK + EL +K+A+ ES++
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 798 ----EMEQELQTLRFELEDEGKAM--LASLRSELNHQHAAAIDLLRHNHHQELAAAKMEL 851
++QE+ L ++ + GK + L ++ ++ + EL AA E
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC------------ELQAALEEA 1553
Query: 852 ERSIDISRRQSKEHICRI-TDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKE 910
E S++ + I RI +L + + I+E D+E+ L N + + ++
Sbjct: 1554 EASLE----HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609
Query: 911 ILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQ 970
+R R+++ + + E DLN E E+ + A+ + + + ++ T +LK+ L
Sbjct: 1610 EIRSRNDAIRLKKKMEGDLN---EMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLD 1664
Query: 971 VSL---EEMEEKYLMRESKPEDIQM-ITELKAML--TERDQII--KKLIEDNKFYQL 1019
+L E+++E+ M E + +Q I EL+A L TER + I ++L++ ++ QL
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Score = 85.1 bits (209), Expect = 3e-16
Identities = 137/670 (20%), Positives = 271/670 (40%), Gaps = 101/670 (15%)
Query: 38 QEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE--EIQQILAETREKILQYK 95
+E+ ++ ++I + +AL + + + + ++ E E+Q+ L++ ++ Q++
Sbjct: 1319 EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR 1378
Query: 96 SKV-------TEELD-LRRKIQVLESSLEDHIKMKQQALTEFEAYKHR----VEDMQL-- 141
+K TEEL+ ++K+ + E+H++ E K R VED+ L
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 142 ------CAEAQHVQR-----IVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDL 190
CA QR + ++ EE + E + L + K K E L
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 191 QAAH--RREIQELLKSQQDHSASVNKGQEKAEELHRM--EVESLNKMLEELRLERKKLIE 246
+RE + L + D + + +G ++ EL ++ +VE L+ E + +E
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 247 DYEGK-------LNKAQSFYER-------ELDTLKRSQLFTAESLQASKEKEADLRKEFQ 292
EGK LN+ +S +R E+D LKR+ + ES+Q++ + E R +
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618
Query: 293 GQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEM 352
+ + + +++ +L A L + Q L + Q LDDA
Sbjct: 1619 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-------KDTQIHLDDA----- 1666
Query: 353 ALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNE 412
L ++++ +LA R L + I L+AT E + K E E +E
Sbjct: 1667 --LRSQEDLKEQLAMVERRAN-------LLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 413 RLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV 472
R+ L + L + + L+ + Q E+E + EA +N + + ++ +
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA------------RNAEEKAKKAI 1765
Query: 473 TQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ 532
T + +E H +E + N + K LQ+ L+E ++L L+ K Q+Q+
Sbjct: 1766 TDAAMMAEELKKEQDTSAH--LERMKKNMEQTVKDLQLRLDE---AEQLALKGGKKQIQK 1820
Query: 533 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 592
LE ++ E+ Q ++ +GL E + L E + + +D
Sbjct: 1821 --------LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872
Query: 593 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE--IKWTENLRQECS 650
+ + + + + + + E+ +Q +A K K+ H+LE + + + +
Sbjct: 1873 LVDKLQAKVKSYKRQAEEAEEQSNTNLA--------KFRKLQHELEEAEERADIAESQVN 1924
Query: 651 KLREELRLQH 660
KLR + R H
Sbjct: 1925 KLRVKSREVH 1934
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.328
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,425,488
Number of Sequences: 37866
Number of extensions: 1949020
Number of successful extensions: 37335
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 582
Number of HSP's successfully gapped in prelim test: 1498
Number of HSP's that attempted gapping in prelim test: 11908
Number of HSP's gapped (non-prelim): 10330
length of query: 1140
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1027
effective length of database: 13,968,660
effective search space: 14345813820
effective search space used: 14345813820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.