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Search of human proteins with 15431330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
(311 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 632 0.0
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 597 e-171
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 597 e-171
gi|15431332 caspase 1 isoform delta [Homo sapiens] 512 e-145
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 337 6e-93
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 337 6e-93
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 323 2e-88
gi|209870073 caspase 5 isoform c [Homo sapiens] 323 2e-88
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 323 2e-88
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 323 2e-88
gi|209870075 caspase 5 isoform d [Homo sapiens] 261 4e-70
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 152 5e-37
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 110 2e-24
gi|14790115 caspase 3 preproprotein [Homo sapiens] 80 2e-15
gi|14790119 caspase 3 preproprotein [Homo sapiens] 80 2e-15
gi|6912286 caspase 14 precursor [Homo sapiens] 80 3e-15
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 77 1e-14
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 77 2e-14
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 77 2e-14
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 76 3e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens] 69 4e-12
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 69 4e-12
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 69 4e-12
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 65 8e-11
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 65 8e-11
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 65 1e-10
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 65 1e-10
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 65 1e-10
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 65 1e-10
gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 61 1e-09
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 632 bits (1631), Expect = 0.0
Identities = 311/311 (100%), Positives = 311/311 (100%)
Query: 1 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60
MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY
Sbjct: 1 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60
Query: 61 PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT 120
PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT
Sbjct: 61 PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT 120
Query: 121 ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL 180
ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL
Sbjct: 121 ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL 180
Query: 181 KDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSS 240
KDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSS
Sbjct: 181 KDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSS 240
Query: 241 TPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT 300
TPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT
Sbjct: 241 TPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT 300
Query: 301 LTRCFYLFPGH 311
LTRCFYLFPGH
Sbjct: 301 LTRCFYLFPGH 311
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 597 bits (1540), Expect = e-171
Identities = 292/295 (98%), Positives = 293/295 (99%)
Query: 17 MGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 76
+ APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC
Sbjct: 89 LSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 148
Query: 77 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 136
NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS
Sbjct: 149 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 208
Query: 137 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS 196
TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS
Sbjct: 209 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS 268
Query: 197 PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF 256
PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF
Sbjct: 269 PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF 328
Query: 257 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 329 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
Score = 40.0 bits (92), Expect = 0.003
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 597 bits (1539), Expect = e-171
Identities = 292/292 (100%), Positives = 292/292 (100%)
Query: 20 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 79
APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE
Sbjct: 113 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 172
Query: 80 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 139
FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL
Sbjct: 173 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 232
Query: 140 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV 199
VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV
Sbjct: 233 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV 292
Query: 200 VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR 259
VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR
Sbjct: 293 VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR 352
Query: 260 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 353 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
Score = 40.0 bits (92), Expect = 0.003
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 512 bits (1318), Expect = e-145
Identities = 263/311 (84%), Positives = 263/311 (84%), Gaps = 48/311 (15%)
Query: 1 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60
MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY
Sbjct: 1 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60
Query: 61 PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT 120
PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT
Sbjct: 61 PIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT 120
Query: 121 ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL 180
ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL
Sbjct: 121 ELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSL 180
Query: 181 KDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSS 240
KDKPKVIIIQACRGD
Sbjct: 181 KDKPKVIIIQACRGD--------------------------------------------- 195
Query: 241 TPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT 300
NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT
Sbjct: 196 ---NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT 252
Query: 301 LTRCFYLFPGH 311
LTRCFYLFPGH
Sbjct: 253 LTRCFYLFPGH 263
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 337 bits (865), Expect = 6e-93
Identities = 166/281 (59%), Positives = 208/281 (74%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 41 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+
Sbjct: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 337 bits (865), Expect = 6e-93
Identities = 166/281 (59%), Positives = 208/281 (74%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 97 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 156
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 157 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 216
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 217 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 276
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+
Sbjct: 277 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 336
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 337 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 167 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 226
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 227 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 286
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 287 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 346
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 347 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 406
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 407 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 12 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 71
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 72 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 131
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 132 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 191
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 192 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 251
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 252 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 96 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 155
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 156 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 215
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 216 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 275
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 276 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 335
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 336 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 154 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 213
Query: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 214 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 273
Query: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 274 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 333
Query: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 334 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 393
Query: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 394 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 261 bits (668), Expect = 4e-70
Identities = 130/216 (60%), Positives = 156/216 (72%)
Query: 96 MTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKH 155
M LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 156 SEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLP 215
++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 216 TTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEE 275
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C + E
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 276 IFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
IFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 152 bits (383), Expect = 5e-37
Identities = 72/81 (88%), Positives = 73/81 (90%)
Query: 231 EKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 290
EK + S DNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR
Sbjct: 8 EKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 67
Query: 291 AQMPTTERVTLTRCFYLFPGH 311
AQMPTTERVTLTRCFYLFPGH
Sbjct: 68 AQMPTTERVTLTRCFYLFPGH 88
Score = 40.0 bits (92), Expect = 0.003
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 110 bits (275), Expect = 2e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 67 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 122
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
Query: 123 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 182
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
Query: 183 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 236
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
Query: 237 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 296
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
Query: 297 ERV--------TLTRCFYLFPGH 311
R TL R YLFPGH
Sbjct: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 71 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 127
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 128 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 187
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 188 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 246
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 247 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 285
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 71 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 127
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 128 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 187
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 188 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 246
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 247 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 285
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 79.7 bits (195), Expect = 3e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 67 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 126
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
Query: 127 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
Query: 185 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 242
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
Query: 243 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 295
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
Query: 296 TE-RVTLTRCFYL 307
E + TL + YL
Sbjct: 229 PEIQSTLRKRLYL 241
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 77.4 bits (189), Expect = 1e-14
Identities = 78/316 (24%), Positives = 128/316 (40%), Gaps = 34/316 (10%)
Query: 1 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60
++ L+ + +R P+ ++ P GS G + +LE + +A++
Sbjct: 98 LSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRG-----NADLA 152
Query: 61 PIMDKSSRTRLALIICNEEF---DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASD 117
I+ LII N F + RTG+ +D + +L + V+VK +LTA
Sbjct: 153 YILSMEPCGH-CLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKK 211
Query: 118 MTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDI-------LQLNAIFN 170
M L A + +H D +V +SHG C H + + + + I N
Sbjct: 212 MVLALLELAQQ-DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVN 265
Query: 171 MLNTKNCPSLKDKPKVIIIQACRGDSPG----VVWFKDSVGVSGNLSLPTTEEFED---- 222
+ N +CPSL KPK+ IQAC G+ V G+ P F++
Sbjct: 266 IFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRT 325
Query: 223 ----DAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFR 278
DAI D S+ P VSWR P GS ++ L + +++A S D++ +
Sbjct: 326 FDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLL 385
Query: 279 KVRFSFEQPDGRAQMP 294
+V + QMP
Sbjct: 386 RVANAVSVKGIYKQMP 401
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 55 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 175 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 234
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 235 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 266
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 55 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 175 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 234
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 235 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 266
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 76.3 bits (186), Expect = 3e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 71 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 130
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
Query: 131 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 190
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
Query: 191 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 250
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
Query: 251 TMGSVFIGRLIEHMQE 266
GS +I L H+++
Sbjct: 410 EEGSWYIQSLCNHLKK 425
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 73 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 104 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 162
Query: 130 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 189
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 163 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 216
Query: 190 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 249
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 217 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 267
Query: 250 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 280
P GS F+ L ++E+ ++ +I +V
Sbjct: 268 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 298
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 73 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 130 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 189
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 190 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 249
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 250 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 280
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 73 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 129
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 130 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 189
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 190 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 249
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 250 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 280
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 65.1 bits (157), Expect = 8e-11
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 34 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 82
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
Query: 83 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 142
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
Query: 143 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 197
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
Query: 198 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 257
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
Query: 258 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 293
L + ++E D+ I +V + D + M
Sbjct: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 65.1 bits (157), Expect = 8e-11
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 34 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 82
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
Query: 83 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 142
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
Query: 143 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 197
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
Query: 198 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 257
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
Query: 258 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 293
L + ++E D+ I +V + D + M
Sbjct: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
KS LII N F SI R G +D +T + L + + + T
Sbjct: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
Query: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
Query: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
Query: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
Query: 289 GRAQM 293
+ M
Sbjct: 440 DKKNM 444
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
KS LII N F SI R G +D +T + L + + + T
Sbjct: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
Query: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
Query: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
Query: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
Query: 289 GRAQM 293
+ M
Sbjct: 440 DKKNM 444
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 65 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
KS LII N F SI R G +D +T + L + + + T
Sbjct: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
Query: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 306 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 361
Query: 175 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 229
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 362 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 414
Query: 230 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 288
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 415 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 471
Query: 289 GRAQM 293
+ M
Sbjct: 472 DKKNM 476
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 64.7 bits (156), Expect = 1e-10
Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 22/256 (8%)
Query: 68 RTRLALIICNEEFD---SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEA 124
R +ALI +E F ++P R G D +T +LG+ V +L A ++ ++
Sbjct: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
Query: 125 FAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184
+ H +D VF+SHG EG H +++ + + C SL KP
Sbjct: 103 VS-TVSHADADCFVCVFLSHG--EG----NHIYAYDAKIEIQTLTGLFKGDKCHSLVGKP 155
Query: 185 KVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTT-EEFEDDAIKKAHIEKDFIAFCSSTPD 243
K+ IIQACRG+ V V + L T E + ++ DF+ S
Sbjct: 156 KIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 215
Query: 244 NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKV---RFSF-EQPD--GRAQM 293
S R GS +I L E + +Y S + E+ RKV R F + P G+ Q+
Sbjct: 216 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 275
Query: 294 PTTERVTLTRCFYLFP 309
P + LT+ + FP
Sbjct: 276 PCFASM-LTKKLHFFP 290
>gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 1 [Homo sapiens]
Length = 197
Score = 61.2 bits (147), Expect = 1e-09
Identities = 28/39 (71%), Positives = 31/39 (79%)
Query: 17 MGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQK 55
+ A QAVQDNPAMPT S EG +KLC LE+AQRIWKQK
Sbjct: 89 LSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQK 127
Score = 38.1 bits (87), Expect = 0.010
Identities = 18/19 (94%), Positives = 18/19 (94%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFI SMGE
Sbjct: 1 MADKVLKEKRKLFIHSMGE 19
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,946,633
Number of Sequences: 37866
Number of extensions: 497017
Number of successful extensions: 1206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1135
Number of HSP's gapped (non-prelim): 59
length of query: 311
length of database: 18,247,518
effective HSP length: 102
effective length of query: 209
effective length of database: 14,385,186
effective search space: 3006503874
effective search space used: 3006503874
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.