Guide to the Human Genome
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Search of human proteins with 154146223

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
         (805 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...  1624   0.0  
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...  1624   0.0  
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]    131   2e-30
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...   129   1e-29
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...   129   1e-29
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...   129   1e-29
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]         123   6e-28
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   118   2e-26
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]       111   2e-24
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 108   3e-23
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]       106   7e-23
gi|33356174 pinin, desmosome associated protein [Homo sapiens]        101   2e-21
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]    100   4e-21
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...   100   7e-21
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi...    98   3e-20
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       97   8e-20
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       96   2e-19
gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens]          95   2e-19
gi|148746195 trichohyalin [Homo sapiens]                               94   4e-19
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]           91   6e-18
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]           91   6e-18
gi|169218320 PREDICTED: similar to BCL2-associated transcription...    89   2e-17
gi|117938254 BCL2-associated transcription factor 1 isoform 3 [H...    89   2e-17
gi|7661958 BCL2-associated transcription factor 1 isoform 1 [Hom...    89   2e-17
gi|125656165 THO complex 2 [Homo sapiens]                              89   2e-17
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]            89   2e-17
gi|239756568 PREDICTED: similar to BCL2-associated transcription...    88   4e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            87   5e-17
gi|117938251 BCL2-associated transcription factor 1 isoform 2 [H...    87   5e-17
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                87   6e-17

>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 1624 bits (4206), Expect = 0.0
 Identities = 805/805 (100%), Positives = 805/805 (100%)

Query: 1   MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM 60
           MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM
Sbjct: 1   MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM 60

Query: 61  MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV 120
           MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV
Sbjct: 61  MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV 120

Query: 121 PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH 180
           PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH
Sbjct: 121 PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH 180

Query: 181 PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL 240
           PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL
Sbjct: 181 PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL 240

Query: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300
           EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300

Query: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD 360
           EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD
Sbjct: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD 360

Query: 361 AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR 420
           AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR
Sbjct: 361 AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR 420

Query: 421 QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN 480
           QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN
Sbjct: 421 QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN 480

Query: 481 EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS 540
           EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS
Sbjct: 481 EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS 540

Query: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600
           GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN
Sbjct: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600

Query: 601 SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660
           SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA
Sbjct: 601 SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660

Query: 661 KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT 720
           KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT
Sbjct: 661 KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT 720

Query: 721 FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR 780
           FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR
Sbjct: 721 FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR 780

Query: 781 SRSVEKSQRSGKKASRKHKSKSRSR 805
           SRSVEKSQRSGKKASRKHKSKSRSR
Sbjct: 781 SRSVEKSQRSGKKASRKHKSKSRSR 805


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 1624 bits (4206), Expect = 0.0
 Identities = 805/805 (100%), Positives = 805/805 (100%)

Query: 1   MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM 60
           MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM
Sbjct: 1   MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM 60

Query: 61  MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV 120
           MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV
Sbjct: 61  MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV 120

Query: 121 PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH 180
           PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH
Sbjct: 121 PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH 180

Query: 181 PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL 240
           PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL
Sbjct: 181 PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL 240

Query: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300
           EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300

Query: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD 360
           EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD
Sbjct: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD 360

Query: 361 AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR 420
           AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR
Sbjct: 361 AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR 420

Query: 421 QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN 480
           QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN
Sbjct: 421 QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN 480

Query: 481 EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS 540
           EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS
Sbjct: 481 EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS 540

Query: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600
           GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN
Sbjct: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600

Query: 601 SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660
           SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA
Sbjct: 601 SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660

Query: 661 KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT 720
           KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT
Sbjct: 661 KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT 720

Query: 721 FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR 780
           FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR
Sbjct: 721 FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR 780

Query: 781 SRSVEKSQRSGKKASRKHKSKSRSR 805
           SRSVEKSQRSGKKASRKHKSKSRSR
Sbjct: 781 SRSVEKSQRSGKKASRKHKSKSRSR 805


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score =  131 bits (330), Expect = 2e-30
 Identities = 108/353 (30%), Positives = 173/353 (49%), Gaps = 42/353 (11%)

Query: 475 DGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSS 534
           DG  VN +K        ++E K   + +    RSRS S S  S S +SR S + S  S S
Sbjct: 161 DGTEVNGRK------IRLVEDKPGSRRRRSYSRSRSHSRSR-SRSRHSRKSRSRSGSSKS 213

Query: 535 SYSSSSGSSRTSSRSSSPKRKKRHSRSRS-------PTIKARRSRSRSYSRRIKIESNRA 587
           S+S S   SR+ SRS S  R +  SRSRS       P+ +  RSRS S  +      ++A
Sbjct: 214 SHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQA 273

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRT---NRASRSRSRDRRKIDD 644
             KI+     N +++ + + R+ S  + + +SRSRS++RR     R S SR R + K   
Sbjct: 274 EEKIQ-----NNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEK--- 325

Query: 645 QRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKF 704
                S    + +  +K   R + RSRS  KD++K  K    E   R   + + E+  K 
Sbjct: 326 -----SLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKR 380

Query: 705 SSQDD------RLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSG 758
            S+ D      + K+K +++R+ SRS S SV   R  ++ +S +   +   +++G++   
Sbjct: 381 GSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQET 440

Query: 759 RSSSESPGSSK-----EKKAKKPKHSRSRSVEKSQ-RSGKKASRKHKSKSRSR 805
           RS S S   SK     E +++    S++RS  KS+ RS  ++  + +S+S SR
Sbjct: 441 RSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493



 Score =  105 bits (263), Expect = 1e-22
 Identities = 91/321 (28%), Positives = 146/321 (45%), Gaps = 40/321 (12%)

Query: 463 QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNS 522
           ++S S   +R   G     K R+ +++ S    KKE      + +SRS S S+G S S S
Sbjct: 212 KSSHSKSRSRSRSGSRSRSKSRSRSQSRS--RSKKEKSRSPSKEKSRSRSHSAGKSRSKS 269

Query: 523 RTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKI 582
           +  +     ++ +       S +  +S S  R +   R      +   SR RS  + ++ 
Sbjct: 270 KDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQ 329

Query: 583 ESNRARVKIRDRRRSNRNSIERERRRNRSPSRE--RRRSRSRSRDRRTNRASRSRSRDRR 640
             +R+R K   R RS   S  +++R+ R  SRE  R RSRSRS+  R+           R
Sbjct: 330 SRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERS-----------R 378

Query: 641 KIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEK 700
           K   +R + +G+S K K E  ++ + +  SRS+        KERE  + +  +++ R E 
Sbjct: 379 KRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSV-------SKEREHAKSESSQREGRGES 431

Query: 701 DFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRS 760
           +   ++Q+ R +         SRS S S   +  +SR  SK +    SK  S S S  RS
Sbjct: 432 ENAGTNQETRSR---------SRSNSKSKPNLPSESRSRSKSA----SKTRSRSKSRSRS 478

Query: 761 SSESPGSSKEKKAKKPKHSRS 781
           +S SP  S+ +      HSRS
Sbjct: 479 ASRSPSRSRSR-----SHSRS 494



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 78/288 (27%), Positives = 122/288 (42%), Gaps = 19/288 (6%)

Query: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVT 452
           SG S+   S   S S        + R R +  +  +KEK +    +K         +  +
Sbjct: 208 SGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRS 267

Query: 453 KEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGS 512
           K  ++   K QN+           +V   K R+P+   S  + +   +E+  +   R   
Sbjct: 268 KSKDQAEEKIQNN----------DNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSV 317

Query: 513 SSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPT-IKARRS 571
           S   S   + R S + S     S S S   S++  +    KR +  SRSRS +  K+ RS
Sbjct: 318 SRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERS 377

Query: 572 RSRSYSRRIKIESNRARVK---IRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRT 628
           R R   R  K  S++ + K    R + RS   S+ +ER   +S S  +R  R  S +  T
Sbjct: 378 RKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSES-SQREGRGESENAGT 436

Query: 629 NRASRSRSRDRRKIDDQRGNLSGNSH-KHKGEAKEQERKKERSRSIDK 675
           N+ +RSRSR   K    + NL   S  + K  +K + R K RSRS  +
Sbjct: 437 NQETRSRSRSNSK---SKPNLPSESRSRSKSASKTRSRSKSRSRSASR 481



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 71/342 (20%), Positives = 129/342 (37%), Gaps = 71/342 (20%)

Query: 237 REGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEED 296
           R G     + + +   + R ++++S+   KEK  +     G   +   +SK  ++E+ ++
Sbjct: 223 RSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAG---KSRSKSKDQAEEKIQN 279

Query: 297 TENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYY 356
            +NV    S   +R  S       S     EEEK   +                      
Sbjct: 280 NDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSV---------------------- 317

Query: 357 VAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELR 416
                     ++  K L QS + +   G           S+D+R  R       ++   R
Sbjct: 318 -------SRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGR---KRSREESRSR 367

Query: 417 HRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADG 476
            R R K E   ++  ++        +++K+ T+R                          
Sbjct: 368 SRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDR-------------------------- 401

Query: 477 DVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSY 536
                + R+P+ + S    ++EH + E   R   G S +  ++  +R+ S S++ S  + 
Sbjct: 402 ----SQSRSPSRSVS---KEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNL 454

Query: 537 SSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR 578
            S    SR+ S+S+S  R +  SRSRS +    RSRSRS+SR
Sbjct: 455 PS---ESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 61/268 (22%), Positives = 113/268 (42%), Gaps = 28/268 (10%)

Query: 363 RKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQK 422
           ++ +++P+K+ ++S +            + +G S  +  D+  E    +D   + + R  
Sbjct: 244 KEKSRSPSKEKSRSRS------------HSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSP 291

Query: 423 QEAFWRKEKEQQLLHDKQMEEEKQQT-------ERVTKEMNEFIHKEQNSLSLLEAREAD 475
                 K K +    ++++EEEK+ +       E+  ++       +  S S   +R   
Sbjct: 292 SR-HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKS 350

Query: 476 GDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSS 535
            D    +KR+  E+ S    +   + K ++ R R     S + SS  +    +    S S
Sbjct: 351 KDKRKGRKRSREESRS----RSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRS 406

Query: 536 YSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR---RIKIES-NRARVKI 591
            S S    R  ++S S +R+ R     + T +  RSRSRS S+    +  ES +R++   
Sbjct: 407 PSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSAS 466

Query: 592 RDRRRSNRNSIERERRRNRSPSRERRRS 619
           + R RS   S    R  +RS SR   RS
Sbjct: 467 KTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 31/113 (27%), Positives = 46/113 (40%), Gaps = 2/113 (1%)

Query: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
           K ++ E   +F S  D  +   + + T      I +   +  SR+    S ++   +   
Sbjct: 137 KGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRS 196

Query: 754 SDSSGRSSSESPGSSKEKKAKKPKHSR--SRSVEKSQRSGKKASRKHKSKSRS 804
                R S    GSSK   +K    SR  SRS  KS+   +  SR  K KSRS
Sbjct: 197 RSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score =  129 bits (324), Expect = 1e-29
 Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%)

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513
           N  I K         A+E + +V+   +   +  ++ +EP+     + K GRSRS   S 
Sbjct: 257 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315

Query: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
           S  SS S+SR   + S   S S++ S    +   RS SP +K+  SR R      R+SRS
Sbjct: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 369

Query: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
           RS+SR              D+R+  R  I +E+ R +   RE+ R R + R++   R  +
Sbjct: 370 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 413

Query: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693
           ++ RD+ +             K + + KE++R++ER +  +KDR   DKE+E+EQDK KE
Sbjct: 414 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 458

Query: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
           ++K   K+       D  ++K +  RT  RS + S +  R  SR+  ++ +   S+    
Sbjct: 459 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 511

Query: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
           S +  R SS SP   S+ KK KK +  R    E+ +R    + RK
Sbjct: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%)

Query: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
           S + R  R    S    ++ R +I++K+     KEK+++   +++ E EK++     K+ 
Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 417

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
           ++   K++        ++ + D   E+++   +     + K++ KEKE++          
Sbjct: 418 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470

Query: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
                 SRT   S   S  S SSS    R  SRSSS       S   S TIK + SRS S
Sbjct: 471 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 524

Query: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
                                 +RN  +++R + R    ER     R R+R T+    S 
Sbjct: 525 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 559

Query: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
            RD ++             K+    KE+E  KE   S+ K+   KD  R  E
Sbjct: 560 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           ++RR   S  + R +S      +      D  K        +E +++ +REK+++ EKER
Sbjct: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405

Query: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314
             E++R +   ++K+  +D E         + K    E E + E+ +     K       
Sbjct: 406 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 456

Query: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374
             +E+    E+ E+ K                            KD   K ++ P +   
Sbjct: 457 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 485

Query: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434
            S    S           S      R  R S  S    + ++ +  +      R +K   
Sbjct: 486 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 531

Query: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
              DK+ E+E+   +ER  +E +  + K  N     E  E +   + EK+      +SV 
Sbjct: 532 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 587

Query: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529
              KE  +K+      +    +G+   N    ST +
Sbjct: 588 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 621


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score =  129 bits (324), Expect = 1e-29
 Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%)

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513
           N  I K         A+E + +V+   +   +  ++ +EP+     + K GRSRS   S 
Sbjct: 141 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 199

Query: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
           S  SS S+SR   + S   S S++ S    +   RS SP +K+  SR R      R+SRS
Sbjct: 200 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 253

Query: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
           RS+SR              D+R+  R  I +E+ R +   RE+ R R + R++   R  +
Sbjct: 254 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 297

Query: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693
           ++ RD+ +             K + + KE++R++ER +  +KDR   DKE+E+EQDK KE
Sbjct: 298 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 342

Query: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
           ++K   K+       D  ++K +  RT  RS + S +  R  SR+  ++ +   S+    
Sbjct: 343 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 395

Query: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
           S +  R SS SP   S+ KK KK +  R    E+ +R    + RK
Sbjct: 396 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 440



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%)

Query: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
           S + R  R    S    ++ R +I++K+     KEK+++   +++ E EK++     K+ 
Sbjct: 245 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 301

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
           ++   K++        ++ + D   E+++   +     + K++ KEKE++          
Sbjct: 302 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 354

Query: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
                 SRT   S   S  S SSS    R  SRSSS       S   S TIK + SRS S
Sbjct: 355 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 408

Query: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
                                 +RN  +++R + R    ER     R R+R T+    S 
Sbjct: 409 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 443

Query: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
            RD ++             K+    KE+E  KE   S+ K+   KD  R  E
Sbjct: 444 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 485



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           ++RR   S  + R +S      +      D  K        +E +++ +REK+++ EKER
Sbjct: 230 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 289

Query: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314
             E++R +   ++K+  +D E         + K    E E + E+ +     K       
Sbjct: 290 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 340

Query: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374
             +E+    E+ E+ K                            KD   K ++ P +   
Sbjct: 341 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 369

Query: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434
            S    S           S      R  R S  S    + ++ +  +      R +K   
Sbjct: 370 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 415

Query: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
              DK+ E+E+   +ER  +E +  + K  N     E  E +   + EK+      +SV 
Sbjct: 416 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 471

Query: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529
              KE  +K+      +    +G+   N    ST +
Sbjct: 472 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 505


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score =  129 bits (323), Expect = 1e-29
 Identities = 90/263 (34%), Positives = 145/263 (55%), Gaps = 19/263 (7%)

Query: 543 SRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV----KIRDRRRSN 598
           SR+  RS SP+R  R SRSRS   +   S S  + R ++ E  R R+    K R++ R  
Sbjct: 260 SRSPRRSLSPRRSPRRSRSRSHHREGHGSSS--FDRELEREKERQRLEREAKEREKERRR 317

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH-KHK 657
             SI+R   R RS SRER RSRSRSRDR+ +R  R R R++   +++RG      + K +
Sbjct: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK---ENERGRRRDRDYDKER 374

Query: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRES 717
           G  +E+ER++ R RS ++  + + +E++ ++DK   + + +++D K   +  R + +   
Sbjct: 375 GNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK 434

Query: 718 ERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPG-SSKEKKAKKP 776
            R+ SRS +   +     SR  SK+ ++K  K  S   S+ RS S S G +   +K+KK 
Sbjct: 435 HRSRSRSRNAGKR-----SRSRSKEKSSK-HKNESKEKSNKRSRSGSQGRTDSVEKSKKR 488

Query: 777 KHSRSRSVEKSQRSGKKASRKHK 799
           +HS S+  EKS++  +   R HK
Sbjct: 489 EHSPSK--EKSRKRSRSKERSHK 509



 Score =  109 bits (272), Expect = 1e-23
 Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 42/337 (12%)

Query: 471 AREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSST 530
           A E D  V   + R+P  +   L P++  +    +   R G  SS       R       
Sbjct: 248 AEEIDRHVERRRSRSPRRS---LSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQ-- 302

Query: 531 VSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVK 590
                        R    +   ++++R SRS    ++ RRSRSR   R      +R+R +
Sbjct: 303 -------------RLEREAKEREKERRRSRSIDRGLERRRSRSRERHR----SRSRSRDR 345

Query: 591 ---IRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRG 647
               RDR R      ER RRR+R   +ER   R + R+R   R+   RSR   ++++++ 
Sbjct: 346 KGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG--EVEEKKH 403

Query: 648 NLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQ 707
               +  +H+ + ++ +++K+ SRS  ++RK + + R R   KR  + + +EK  K  ++
Sbjct: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR-SRSRSKEKSSKHKNE 462

Query: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767
                 KR      SRSGS      R DS + SKK     SK+ S   S  +  S     
Sbjct: 463 SKEKSNKR------SRSGSQG----RTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDH 512

Query: 768 SKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
           S + K +  KH R RS    Q S +K   +HK+K  +
Sbjct: 513 S-DSKDQSDKHDRRRSQSIEQESQEK---QHKNKDET 545



 Score =  103 bits (257), Expect = 6e-22
 Identities = 76/253 (30%), Positives = 123/253 (48%), Gaps = 20/253 (7%)

Query: 566 IKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
           ++ RRSRS   S   +    R+R +   R     +S +RE  R +   R  R ++ R ++
Sbjct: 255 VERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKE 314

Query: 626 RRTNRA-------SRSRSRDRRKIDDQRGNLSGNSH-KHKGEAKEQERKKERSRSIDKDR 677
           RR +R+        RSRSR+R +   +  +  G+   + +   KE ER + R R  DK+R
Sbjct: 315 RRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKER 374

Query: 678 -KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHD- 735
             +++KERER +++ KE++ R E + K   +D   +R R+ +R        S K  +H  
Sbjct: 375 GNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRD-------SKKEKKHSR 427

Query: 736 SRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKAS 795
           SR   +K  ++   +++G  S  RS  +S     E K K  K SRS S  ++    K   
Sbjct: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKK 487

Query: 796 RKH---KSKSRSR 805
           R+H   K KSR R
Sbjct: 488 REHSPSKEKSRKR 500



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 72/269 (26%), Positives = 117/269 (43%), Gaps = 16/269 (5%)

Query: 400 RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFI 459
           R   GS S D + E  + R R ++EA   KE+E++    + ++   ++    ++E +   
Sbjct: 283 REGHGSSSFDRELEREKERQRLEREA---KEREKERRRSRSIDRGLERRRSRSRERHRSR 339

Query: 460 HKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS 519
            + ++       R+ + +  NE+ R  +         +  KE+E+  R RS    S    
Sbjct: 340 SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS-RERSKEQRSRGEV 398

Query: 520 SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRR 579
              +                S   +  SRS S +RK R SRSRS     +RSRSRS  + 
Sbjct: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR-SRSRSRNA-GKRSRSRSKEKS 456

Query: 580 IKIESNRARVKIRDRRRSNR----NSIERERRRNRSPSRERRRSRSRSRDRRTNR----- 630
            K   N ++ K   R RS      +S+E+ ++R  SPS+E+ R RSRS++R   R     
Sbjct: 457 SK-HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDS 515

Query: 631 ASRSRSRDRRKIDDQRGNLSGNSHKHKGE 659
             +S   DRR+            HK+K E
Sbjct: 516 KDQSDKHDRRRSQSIEQESQEKQHKNKDE 544



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 92/414 (22%), Positives = 158/414 (38%), Gaps = 92/414 (22%)

Query: 213 IALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATE 272
           I +PV++   Q    + R +    +EG E+++R     +E+ R    R  LS +      
Sbjct: 221 IPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRH----VERRRSRSPRRSLSPR------ 270

Query: 273 DAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEY 332
                   R P+RS+  S   E          S    R      + +  + E  E EKE 
Sbjct: 271 --------RSPRRSRSRSHHRE-------GHGSSSFDRELEREKERQRLEREAKEREKER 315

Query: 333 QMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG 392
           +             +D   E     +++ HR  +++  ++                G   
Sbjct: 316 RRSRS---------IDRGLERRRSRSRERHRSRSRSRDRK----------------GDRR 350

Query: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQ-EAFWRKEKEQQLLHDKQMEEEKQQTERV 451
             D E E+ +      D D ++ R   R+K+ E    + KEQ                R 
Sbjct: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ----------------RS 394

Query: 452 TKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG 511
             E+ E  HKE       + R  D    ++K++  + + S          +E++ RSRS 
Sbjct: 395 RGEVEEKKHKEDKD----DRRHRDDKRDSKKEKKHSRSRS----------RERKHRSRSR 440

Query: 512 SSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRS 571
           S ++G   S SR+   SS   + S   S+  SR+ S+  +   +K   R  SP+ +  R 
Sbjct: 441 SRNAG-KRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK 499

Query: 572 RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
           RSRS  R  K          RD   S   S + +RRR++S  +E +  + +++D
Sbjct: 500 RSRSKERSHK----------RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score =  123 bits (309), Expect = 6e-28
 Identities = 173/716 (24%), Positives = 279/716 (38%), Gaps = 80/716 (11%)

Query: 108 PWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQ 167
           P  P T     + P S  S    S + AP NR        +    P   +         +
Sbjct: 46  PTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASK 105

Query: 168 HGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAV 227
                   + G H     PG          RR   SS R   R+     ++    +    
Sbjct: 106 ASDVRCHQRRGTHSRGRTPG----------RRGSRSSKRSPSRASTPGRIRTHGARPGMA 155

Query: 228 KRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSK 287
            R   P   ++G       + +   +ER + Q   LSKK  +      GG G        
Sbjct: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPP----GGSGIG------ 205

Query: 288 FDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSD---PEMTEEEKEYQMMLLTKMLLTE 344
                    +E     S+ K  ++P+ +P +E SD   P  + + K Y  M++     + 
Sbjct: 206 -------RSSELAVTPSTAKC-QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS- 256

Query: 345 ILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG 404
                +  E+    K  ++ +T++  +  +QS +              SG  +   S   
Sbjct: 257 ----YSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSR---------SGSQKRTHSRVR 303

Query: 405 SESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQN 464
           S S   +    R R R K          Q   H K   + + +T R  +  N        
Sbjct: 304 SHSWKRNHSRARSRTR-KGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNW------- 355

Query: 465 SLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRT 524
           S +  + R       + K+R    ++S   P+KE       GRS+SGS +     S SR+
Sbjct: 356 SRNPSKERSHSHSRSSSKERDHRGSSS---PRKE------SGRSQSGSPNKQRDHSRSRS 406

Query: 525 SSTSSTVSSS---------SYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
            + +   S S         S S S   +R  SRS SP + +  SRSRSP      SRSRS
Sbjct: 407 PNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRS 466

Query: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER--RRSRSRSRDRRTNRASR 633
            ++      +R+  K RD  +    S ER+ RR+RSPS+ER  R+SRS S++R  +R SR
Sbjct: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER-DHRRSR 525

Query: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKK---KDKEREREQDK 690
           S S++R++   +  N   +  + +  ++E+E ++ RS S ++DR++     KERER Q  
Sbjct: 526 SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQ-S 584

Query: 691 RKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVKIIRHDSRQDSKKSTTKDS 748
           R   ++R+    +  ++     R R S  E+  SRS + S +     SR  SK+S    S
Sbjct: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQS 644

Query: 749 KKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
                 D     +  S  S     +K   HS S      Q   +  S+   + S++
Sbjct: 645 TVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700



 Score =  120 bits (300), Expect = 7e-27
 Identities = 103/311 (33%), Positives = 149/311 (47%), Gaps = 30/311 (9%)

Query: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTS-SRSSSPKRK 555
           K   +     R RS + S   S   S + S SS+       SSS    +  S+S SP ++
Sbjct: 339 KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQ 398

Query: 556 KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRE 615
           + HSRSRSP     RSRSRS  +      +R+  K RD  RS      R+R R+RSP++ 
Sbjct: 399 RDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKA 458

Query: 616 RRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDK 675
           R  SRSRS ++  +R SRSRS  + +   Q G+ S      +  +  +ER+  +SRS  K
Sbjct: 459 RDHSRSRSPNKARDR-SRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSK 517

Query: 676 DRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHD 735
           +R     +  R +   KE+Q+R+ +              +E +R+ SRS S        +
Sbjct: 518 ER-----DHRRSRSPSKERQRRQSRS-----------PNKERDRSQSRSPSEE-----RE 556

Query: 736 SRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEK-SQRSGKKA 794
            RQ    S  +D ++   S S  R   +S  SS+E+      HSRSRS  K S  S  +A
Sbjct: 557 HRQSRSPSKERDRRRWR-SPSKERERRQSRSSSEER-----DHSRSRSPNKQSGYSRPRA 610

Query: 795 SRKHKSKSRSR 805
           S K K+ SRSR
Sbjct: 611 SSKEKAHSRSR 621



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 93/361 (25%), Positives = 140/361 (38%), Gaps = 42/361 (11%)

Query: 482 KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSS-S 540
           K  TPN +    +P            S+S  S+S   + ++R SS S   S +   S  S
Sbjct: 36  KSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVS 95

Query: 541 GSSRTSSRSSSP-----KRKKRHSRSRSPTIKARRSRSRSYSR-----RIKIE------S 584
             +RTS  S +      +R+  HSR R+P  +  RS  RS SR     RI+        +
Sbjct: 96  TDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMA 155

Query: 585 NRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD------ 638
           +R R     ++ S   S  R R  NR  S  + R+ S+   R    +   RS +      
Sbjct: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPS 215

Query: 639 -----------RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
                       ++  D     S    K  G+     R+K  S +    R K   +    
Sbjct: 216 TAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTR 275

Query: 688 QDKRKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVK-IIRHDSRQDSKKST 744
              +   Q R  +  +  SQ     R R    +R  SR+ S + K I+    R    +S 
Sbjct: 276 SRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSH 335

Query: 745 TKD-SKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803
           +K  S+  S +   GRS + S   SKE   +   HSRS S E+  R G  + RK   +S+
Sbjct: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKE---RSHSHSRSSSKERDHR-GSSSPRKESGRSQ 391

Query: 804 S 804
           S
Sbjct: 392 S 392


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score =  118 bits (295), Expect = 2e-26
 Identities = 97/435 (22%), Positives = 184/435 (42%), Gaps = 43/435 (9%)

Query: 384 GLGGLGGYGSGDSED----ERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDK 439
           GLG       GD  +    +  +R  E   T+ E  R R R++++   RK    +   ++
Sbjct: 41  GLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHR---ER 97

Query: 440 QMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEH 499
           Q + EK++  +  +E +    KE+N       +E + +   E +R  +  T     ++  
Sbjct: 98  QRDREKERERQTDRERDRQREKERN-----RQKERERETEREGERGRDRQTDGQRERERQ 152

Query: 500 KEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHS 559
           ++ EK+   ++       +  N +             +      R   R    K + RHS
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREK------NRQERRERERQREKENKTEDRHS 206

Query: 560 RSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERE----------RRRN 609
                     R R R   R  + E+ R R   R+R R  +   ERE          R   
Sbjct: 207 E---------RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257

Query: 610 RSPSRERRRSRSRSRDRRTNRASRS--RSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKK 667
           R   RER R R R RDRR     R   R R RR   D+         + +   +E+ RK+
Sbjct: 258 RDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR 317

Query: 668 ERSRSIDKDR-KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL-KRKRESERTFSRSG 725
           ER R  +++R ++++ ER+RE+++ ++++++ E D + + Q  R  +R+ E ER   R  
Sbjct: 318 ERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERER 377

Query: 726 SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVE 785
                  R +  +D  +   K+ ++ +  D  G+  +E     + +K ++ +  R R  E
Sbjct: 378 DRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEK--QREREKDRESERGRERGRE 435

Query: 786 KSQRSGKKASRKHKS 800
           + ++ G++  R+ ++
Sbjct: 436 REKQKGRERDRERQT 450



 Score =  101 bits (251), Expect = 3e-21
 Identities = 83/377 (22%), Positives = 150/377 (39%), Gaps = 34/377 (9%)

Query: 430 EKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNET 489
           ++E+    +++   EK+QTER T    E   ++         RE   D   E++R  +  
Sbjct: 53  DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112

Query: 490 TSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS 549
                 K+ +++KE++  +       G    + +T                       R 
Sbjct: 113 RDRQREKERNRQKERERETER----EGERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168

Query: 550 SSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRN 609
              +R ++  R R    + RR R R   +  K E   +    R R R      E E  R 
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE---RGRERERERETETETERK 225

Query: 610 RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKER 669
           R   RER R R   R+R   +A R R+ +R    D+               +E+ER +  
Sbjct: 226 RQTDRERDRQRKTERERE-KQAERERASERETERDKE--------------RERERDR-- 268

Query: 670 SRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLK-RKRESERTFSRSGSIS 728
               D+DR ++ KERER+ D++  +Q+R E+D +   + +R + R+RE ER   R     
Sbjct: 269 ----DRDRDRRQKERERQTDRK--RQRRTERDRETERKRERQRERERERERNRKRERERE 322

Query: 729 VKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQ 788
            +  R   R+  +    +  +K        R  +   G    ++A++    R R  E+ +
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAER---ERERERERDR 379

Query: 789 RSGKKASRKHKSKSRSR 805
           +S ++   + + + R R
Sbjct: 380 QSAREREERERDRDRDR 396



 Score =  100 bits (248), Expect = 7e-21
 Identities = 95/421 (22%), Positives = 167/421 (39%), Gaps = 50/421 (11%)

Query: 395 DSEDERSDRGSESSDTDDEELRHRIRQKQEAFWR---KEKEQQLLHDKQMEEEKQQTERV 451
           + E ER         TD +  R R R  ++   R   +E+++Q   ++Q E E+++  + 
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187

Query: 452 TKEMNEFIHKEQNS------LSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQ 505
            +E      KE  +            RE + +   E+KR  +        +K  +E+EKQ
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD--RQRKTEREREKQ 245

Query: 506 G-RSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP--------KRKK 556
             R R+    +       R                  + R   R +          +R++
Sbjct: 246 AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR 305

Query: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRN------R 610
              R R    K  R R R   R  + E+ R R K R+R+R  +  ++RER R       R
Sbjct: 306 ERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365

Query: 611 SPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLS----GNSHKHKGEAKEQERK 666
              RER R R R R     R  R R RDR +  ++         G     K   +E++R+
Sbjct: 366 QAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425

Query: 667 KERSRSIDKDR-KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSG 725
            ER R   ++R K+K +ER+RE+   ++  ++ ++   + +   R           +RSG
Sbjct: 426 SERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT----------ARSG 475

Query: 726 SISVKIIRHDSRQDSK----KSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRS 781
                +++ D  + ++    KS+ +D K  S     GR +  S G    ++  +P+    
Sbjct: 476 -----VVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEK 530

Query: 782 R 782
           R
Sbjct: 531 R 531



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 66/275 (24%), Positives = 136/275 (49%), Gaps = 30/275 (10%)

Query: 542 SSRTSSRSSSPKRK---KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSN 598
           S R      SP+R+   + H  +     +  R + R   RR K ++ R   + R+RRR  
Sbjct: 27  SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERE-RRREKRQTERETDRKRERRR-- 83

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRA---SRSRSRDRRKIDDQRGNLSGNSHK 655
               E++R R R   RER+R R + R+R+T+R     R + R+R+K  ++     G   +
Sbjct: 84  ----EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139

Query: 656 HKGEAKEQER------KKERSRSIDKDR-------KKKDKEREREQDKRKEKQKREEKDF 702
            +    ++ER      +KER R  D++R       ++K++ERE+ + +R+E++++ EK+ 
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN 199

Query: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762
           K   +     R+RE ER    + + + +  + D  +D ++ T ++ +K +  + +    +
Sbjct: 200 KTEDRHSERGRERERER---ETETETERKRQTDRERDRQRKTEREREKQAERERASERET 256

Query: 763 ESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
           E     +E++  + +    R  E+ +++ +K  R+
Sbjct: 257 ER-DKERERERDRDRDRDRRQKERERQTDRKRQRR 290



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 66/268 (24%), Positives = 118/268 (44%), Gaps = 46/268 (17%)

Query: 555 KKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSR 614
           ++R     SP    RR   +++      +  R R K R+RRR  R +   ER  +R   R
Sbjct: 28  RRRPGSQESPR---RRGLGQAHKDADGDDRERNRQKERERRREKRQT---ERETDRKRER 81

Query: 615 ERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID 674
            R + R R RDR      R R RDR K             +     ++++R+KER+R  +
Sbjct: 82  RREKDRHRKRDRH-----RERQRDREK----------ERERQTDRERDRQREKERNRQKE 126

Query: 675 KDR-----------KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSR 723
           ++R           ++ D +RERE+ +  EK++  + D +   Q +R  R++E ER  +R
Sbjct: 127 RERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER-NRQKEREREKNR 185

Query: 724 SGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK------KAKKPK 777
                    R   RQ  K++ T+D     G +      +E+    K +      + +K +
Sbjct: 186 QER------RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTE 239

Query: 778 HSRSRSVEKSQRSGKKASRKHKSKSRSR 805
             R +  E+ +R+ ++ + + K + R R
Sbjct: 240 REREKQAER-ERASERETERDKERERER 266



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 86/411 (20%), Positives = 162/411 (39%), Gaps = 55/411 (13%)

Query: 237 REGLEKMEREKQKKLEKER---MEQQRSQLSKKEKKATEDAEGG-----DGPRLPQRSKF 288
           RE     E+E++++ ++ER    E++R++  ++E++   + E G     DG R  +R + 
Sbjct: 95  RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR- 153

Query: 289 DSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLD 348
             D E+E     +     +  R+     + E +  E  E E++ +    T+   +E   +
Sbjct: 154 --DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211

Query: 349 VTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESS 408
              E       +  R+  +   +Q                      + + ER       +
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTER---------------EREKQAERERASERET 256

Query: 409 DTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEK-QQTERVTKEMNEFIHKEQNSLS 467
           + D E  R R R +     +KE+E+Q    +Q   E+ ++TER  +   E   + +   +
Sbjct: 257 ERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRE--RERERERN 314

Query: 468 LLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSST 527
               RE + +   E++R   ET    E ++E K K +    R  +  +G           
Sbjct: 315 RKRERERERERERERQR---ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER 371

Query: 528 SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA 587
                           R   R S+ +R++R         +  R R R   R  + E +R 
Sbjct: 372 E-------------RERERDRQSAREREER---------ERDRDRDRQKERERQTEKDRD 409

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNR-ASRSRSR 637
             +  +++R      E ER R R   RE+++ R R R+R+T+R A R R R
Sbjct: 410 GQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKR 460



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 49/207 (23%), Positives = 99/207 (47%), Gaps = 17/207 (8%)

Query: 602 IERERRRNRSPSRERRRSRSRS-RDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660
           ++  RRR  S    RRR   ++ +D   +   R+R ++R +  ++R              
Sbjct: 24  LDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQT-----------E 72

Query: 661 KEQERKKERSRSIDKDRKK-KDKEREREQDKRKEKQKREEKDFKFSSQDDRLK-RKRESE 718
           +E +RK+ER R  D+ RK+ + +ER+R+++K +E+Q   E+D +   + +R K R+RE+E
Sbjct: 73  RETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETE 132

Query: 719 RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKH 778
           R   R         R   RQ   +   K+ ++ +  +   ++        + +K ++ + 
Sbjct: 133 REGERGRDRQTDGQRERERQ---RDAEKERERQTDRERQRQTERNRQKEREREKNRQERR 189

Query: 779 SRSRSVEKSQRSGKKASRKHKSKSRSR 805
            R R  EK  ++  + S + + + R R
Sbjct: 190 ERERQREKENKTEDRHSERGRERERER 216



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 83/427 (19%), Positives = 150/427 (35%), Gaps = 92/427 (21%)

Query: 196 QNRRERPSSFR-DRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKK--LE 252
           Q  RER +    +R R       ++   Q DA K R      RE   + ER +QK+   E
Sbjct: 124 QKERERETEREGERGRDRQTDGQRERERQRDAEKERERQT-DRERQRQTERNRQKERERE 182

Query: 253 KERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSP 312
           K R E++  +  ++++  TED     G    +  + +++ E +   + E     K  R  
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERER 242

Query: 313 SPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQ 372
               + E +    TE +KE +                         +D  R   +   ++
Sbjct: 243 EKQAERERASERETERDKERER-----------------------ERDRDRDRDRRQKER 279

Query: 373 LAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKE 432
             Q+                     D +  R +E  D + E  R R R+++    R  K 
Sbjct: 280 ERQT---------------------DRKRQRRTE-RDRETERKRERQRERERERERNRKR 317

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
           ++    ++  E +++TER  ++  E   K Q  +     RE +     E +R        
Sbjct: 318 ERERERERERERQRETERDREKERERKRKRQTEMD----RERNRQTGREGRRQAER---- 369

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552
            E ++E +   +  R R                                  R   R    
Sbjct: 370 -ERERERERDRQSARER------------------------------EERERDRDRDRQK 398

Query: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
           +R+++  + R    +  + R R   R    ES R R + R+R +      +RER+ +R  
Sbjct: 399 ERERQTEKDRDGQRETEKQREREKDR----ESERGRERGREREKQKGRERDRERQTDRQA 454

Query: 613 SRERRRS 619
            R+R+RS
Sbjct: 455 GRQRKRS 461



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 80/392 (20%), Positives = 138/392 (35%), Gaps = 76/392 (19%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           +N+ E   S R R+R       ++   + +  ++R      R+   K ERE++K+ E+ER
Sbjct: 198 ENKTEDRHSERGRERE------RERETETETERKRQTDRE-RDRQRKTEREREKQAERER 250

Query: 256 MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPV 315
             ++ ++   KE++   D +     R  +R +    + +  TE  +  +  K  R     
Sbjct: 251 ASERETE-RDKERERERDRDRDRDRRQKERERQTDRKRQRRTER-DRETERKRERQRERE 308

Query: 316 PQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQ 375
            + E +     E E+E +                  E      +D  ++  +   +Q   
Sbjct: 309 RERERNRKRERERERERER-----------------ERQRETERDREKERERKRKRQTEM 351

Query: 376 SSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQL 435
                              D E  R          + E  R R R +Q A  R+E+E+  
Sbjct: 352 -------------------DRERNRQTGREGRRQAERERERERERDRQSAREREERERDR 392

Query: 436 LHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEP 495
             D+Q E E+ QTE                      ++ DG    EK+R   +       
Sbjct: 393 DRDRQKERER-QTE----------------------KDRDGQRETEKQREREKDRESERG 429

Query: 496 KKEHKEKEKQ-GRSRSGSSSSGSSSSNSRTSST-------SSTVSSSSYSSSSGSSRTSS 547
           ++  +E+EKQ GR R     +   +   R  ST        +  S    S  +  +R   
Sbjct: 430 RERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIR 489

Query: 548 RSSSPKRKKRHSRSRSPTIKARRSRSRSYSRR 579
             SSP+  K  S        A+ SR R   RR
Sbjct: 490 WKSSPEDPKAASTRFPWGRPAKASRGRVAGRR 521


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score =  111 bits (278), Expect = 2e-24
 Identities = 99/326 (30%), Positives = 153/326 (46%), Gaps = 39/326 (11%)

Query: 500 KEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK---- 555
           +  +++GRSRS      S S N++    S +       S S ++R  SRS +P R+    
Sbjct: 526 RSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSR 585

Query: 556 -----KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNR 610
                +R SRSR+PT   RRSRSR+ +RR      R+R +   RRRS   S  R R R+R
Sbjct: 586 SRTPARRRSRSRTPT--RRRSRSRTPARR-----GRSRSRTPARRRSRTRSPVRRRSRSR 638

Query: 611 SPSRERRRSRSRSRDRRTNRASRS---RSRDRRKIDDQRGNLSGN---SHKHKGEAKEQE 664
           SP+R   RSRSR+  RR    SR+   R R R +   +R   S +   + + +  ++   
Sbjct: 639 SPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPR 698

Query: 665 RKKERSRSI-----DKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESER 719
           R + RSRS+        R  + + R     +RK K +  ++  + S+    +K+ R S R
Sbjct: 699 RGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSR-SNSSPEMKKSRISSR 757

Query: 720 TFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHS 779
              RS S+S       S +   KS     +  SGS    +  S++P       + +PK +
Sbjct: 758 ---RSRSLS-------SPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPK-A 806

Query: 780 RSRSVEKSQRSGKKASRKHKSKSRSR 805
           +SR+  +  RS      K KSK+ SR
Sbjct: 807 KSRTPPRRSRSSSSPPPKQKSKTPSR 832



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 142/640 (22%), Positives = 242/640 (37%), Gaps = 86/640 (13%)

Query: 203 SSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERME----- 257
           SSF  ++R+  A     EPP+  ++ R +  +  R    K +++K+KK    R E     
Sbjct: 149 SSFDPQRRAREAKQPAPEPPKPYSLVRESSSS--RSPTPKQKKKKKKKDRGRRSESSSPR 206

Query: 258 QQRSQLSKKEKKATEDAEGGDGPRLPQ-RSKFDSDEEEEDTENVEAASSGKVTRSPSPVP 316
           ++R + SKK+K  +E        R P  +SK  S +++            K +RS +P P
Sbjct: 207 RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKR-----------KRSRSTTPAP 255

Query: 317 QEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQS 376
           +   +    + +                             + D  R  +++ A +   +
Sbjct: 256 KSRRAHRSTSADSAS--------------------------SSDTSRSRSRSAAAK-THT 288

Query: 377 SALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLL 436
           +ALA  +     G  G GD+        S    +  E    +     E   + +KE+   
Sbjct: 289 TALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSAT 348

Query: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
                 E                 +   S   L       + VN     P    S    +
Sbjct: 349 RPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVN-----PPSEASPTRDR 403

Query: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR------TSSRSS 550
              K  EK  +S S  SS  S      +   SS+  S   + + GS R      TS   S
Sbjct: 404 SPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRS 463

Query: 551 SPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRS---NRNSIERERR 607
             + K+  S S +P+ +  RSRS + ++R +  S     +   R RS    R+   +   
Sbjct: 464 HGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWG 523

Query: 608 RNRSPSRERRRSRSR-------SRDRRTNRASRSRS----RDRRKIDDQRGNLSGNSHKH 656
           R+RSP   +RR RSR       SR R T R  RSRS    R   +    RG     +   
Sbjct: 524 RSRSP---QRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPAR 580

Query: 657 KGEAKEQERKKERSRSIDKDRK--------KKDKEREREQDKRKEKQKREEKDFKFSSQD 708
           +G ++ +   + RSRS    R+        ++ + R R   +R+ + +   +  +  S+ 
Sbjct: 581 RGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRR-RSRSRS 639

Query: 709 DRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDS-SGRSSSESP-- 765
              +  R   RT +R G    +      R  S+    +  +  S + +  GRS S +P  
Sbjct: 640 PARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRR 699

Query: 766 GSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           G S+ +   +   S SR+ ++  RSG  + RK+KS++  R
Sbjct: 700 GRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR 739



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 102/361 (28%), Positives = 158/361 (43%), Gaps = 25/361 (6%)

Query: 461  KEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEK----QGRSRSGSSSSG 516
            K ++S     A        + + R+P+     L+  +    +EK    + R RSGSS S 
Sbjct: 1738 KSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQST 1797

Query: 517  S---SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
            S     S SR+  T      S Y S S + + SSR+SS   ++R  RSR+P    +RSRS
Sbjct: 1798 SRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSS---RRRRGRSRTPPTSRKRSRS 1854

Query: 574  RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
            R+     K   +RA      R RS    I R R R+R+    RRRSRSR+    T R SR
Sbjct: 1855 RTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRT--SVTRRRSR 1912

Query: 634  SRSR--DRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKR 691
            SR+    RR+    R      + +         R++ RSR+    R ++ + R     +R
Sbjct: 1913 SRASPVSRRR---SRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTR-RRSRSRTPPVTRR 1968

Query: 692  KEKQK-----REEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTK 746
            + + +     R     + S    R  R R S  T  RS S +  + R  SR  +  +  +
Sbjct: 1969 RSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRR 2028

Query: 747  DSKKHSGSDSSGRSSSESP-GSSKEKKAKKPKHSR-SRSVEKSQRSGKKASRKHKSKSRS 804
             S+  +      RS S SP    +  +++ P+ +R  RS+ +S  + ++ S    S  RS
Sbjct: 2029 RSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRS 2088

Query: 805  R 805
            R
Sbjct: 2089 R 2089



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 108/377 (28%), Positives = 157/377 (41%), Gaps = 37/377 (9%)

Query: 463  QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQG---RSRSGSSSSGSSS 519
            ++ LS   +R      V +K R      S  +   E K    +    RSRSGSSS G   
Sbjct: 1588 KSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGP 1647

Query: 520  SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSS-SPKRKKR-HSRSRSPTIKARRSRSRSYS 577
            S      +SST SS  +   S ++R  SRSS  PK K R   R RS       +R    S
Sbjct: 1648 S---PEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLS 1704

Query: 578  RRIKIESN----RARVKIRDRRRSNRNSIE-----RERRRNRSPSRER-----RRSRSRS 623
            RR +  S+    R+R   R RR  + +S E     R  RR RS S  R     RR RS S
Sbjct: 1705 RRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764

Query: 624  RDRRTNRASRSRSRDRRKIDDQRGNLSGNS-----HKHKGEAKEQERKKER------SRS 672
               R  + SRSRSR  +    +R + SG+S      + +  ++ +  ++ R      SRS
Sbjct: 1765 PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824

Query: 673  IDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKII 732
              +    +   R R    R     R+    + S    +  R R S  T  RS S +  I 
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884

Query: 733  RHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKP----KHSRSRSVEKSQ 788
            R  SR  +   + + S+  +        S  SP S +  +++ P    + SRSR+    +
Sbjct: 1885 RRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944

Query: 789  RSGKKASRKHKSKSRSR 805
            RS  +     + +SRSR
Sbjct: 1945 RSRSRTPPVTRRRSRSR 1961



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 155/675 (22%), Positives = 255/675 (37%), Gaps = 84/675 (12%)

Query: 166 YQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQID 225
           Y  G++F P +        QP P  PP P    RE  SS     RSP     K++  + D
Sbjct: 145 YVDGSSFDPQRRAREAK--QPAPE-PPKPYSLVRESSSS-----RSPTPKQKKKKKKK-D 195

Query: 226 AVKRRTLPAWIREGLEKMEREKQK-----KLEKERMEQQRSQLSKKEKKATEDAEGGDGP 280
             +R    +  RE  +  +++K +     K  K R    +S+   K+KK          P
Sbjct: 196 RGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAP 255

Query: 281 --RLPQRSKFDSDEEEEDTENVEAASSGKVT-------RSPSPVPQEE------HSDPEM 325
             R   RS         DT    + S+   T       RSPSP            S+P  
Sbjct: 256 KSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGT 315

Query: 326 TEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSA------- 378
           T  ++       TK   +       D++     KD   K+   P+    +SS        
Sbjct: 316 TSTQRPSSPETATKQPSSPY----EDKD-----KDKKEKSATRPSPSPERSSTGPEPPAP 366

Query: 379 ---LASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQL 435
              LA   G G      +     E  +  SE+S T D                  K  + 
Sbjct: 367 TPLLAERHG-GSPQPLATTPLSQEPVNPPSEASPTRDRS--------------PPKSPEK 411

Query: 436 LHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEK-KRTPNETTSVLE 494
           L      E    + + TK ++        S     A  +  ++ +    +  +   +  +
Sbjct: 412 LPQSSSSESSPPSPQPTK-VSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRD 470

Query: 495 PKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKR 554
               H    + GRSRS +++    S +   +    + S S     S S++   RS SP+R
Sbjct: 471 KSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQR 530

Query: 555 KKRHSRSRSPT----IKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNR 610
           +    RSRSP      ++R ++ R  SR  +   + +R      R  +R    R R R+R
Sbjct: 531 R---GRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSR 587

Query: 611 SPSRERRRSRSRSRDRRTNRA--SRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE 668
           +P+R  RRSRSR+  RR +R+     R R R +   +R + + +  + +  ++   R+  
Sbjct: 588 TPAR--RRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSG 645

Query: 669 RSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSIS 728
           RSRS    R+ + + R   +  R   +    +  +  S+    +R R   RT  R  S S
Sbjct: 646 RSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTP-ARRGRSRSRTPRRGRSRS 704

Query: 729 VKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQ 788
             ++    R+    S T   +  SGS SS R +       + +    P+  +SR    S+
Sbjct: 705 RSLV----RRGRSHSRTPQRRGRSGS-SSERKNKSRTSQRRSRSNSSPEMKKSRI--SSR 757

Query: 789 RSGKKASRKHKSKSR 803
           RS   +S + K+KSR
Sbjct: 758 RSRSLSSPRSKAKSR 772



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 96/377 (25%), Positives = 158/377 (41%), Gaps = 36/377 (9%)

Query: 465  SLSLLEAREADGDVVNEKK-RTP--NETTSVLEPKKEHKEKEKQGRSRSGSS-------- 513
            S S  E  E+D    ++ K RTP    + S   P+ + K +    RSRSGSS        
Sbjct: 1550 SASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPR 1609

Query: 514  -----SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR------TSSRSSSPKR--KKRHSR 560
                  SGS SS    +     +   S S SS   R      +SS  SSP+   K R +R
Sbjct: 1610 AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTAR 1669

Query: 561  SRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERR--- 617
              S +    +++SR+  RR    S+    +     R +R++      R+R+P R RR   
Sbjct: 1670 RGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPS 1729

Query: 618  -RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKD 676
              S   +   R++R  RS S  R K   +RG       +    ++ + R+++   +  +D
Sbjct: 1730 VSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRD 1789

Query: 677  RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFS---RSGSISVKIIR 733
            R    +   R + + + + +   +    S    R   ++ES RT S   R  S +    R
Sbjct: 1790 RSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSR 1849

Query: 734  HDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKP-----KHSRSRSVEKSQ 788
              SR  +  +  K S+  +   +  RS S +P  S+ +   +      + SRSR+    +
Sbjct: 1850 KRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRR 1909

Query: 789  RSGKKASRKHKSKSRSR 805
            RS  +AS   + +SRSR
Sbjct: 1910 RSRSRASPVSRRRSRSR 1926



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 152/683 (22%), Positives = 249/683 (36%), Gaps = 99/683 (14%)

Query: 182 PYWQPGPPGP--PAPPQNRRERPSS-FRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIRE 238
           P+ +PG      P+ P+   ++PSS + D+ +        +  P  +       P     
Sbjct: 309 PFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTP 368

Query: 239 GLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGP-RLPQRSKFDSDEEEEDT 297
            L +      + L    + Q+       E   T D      P +LPQ S  +S       
Sbjct: 369 LLAERHGGSPQPLATTPLSQEPVN-PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQP 427

Query: 298 ENVEA-ASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYY 356
             V   ASS   +  P+P P                           EI    T +   +
Sbjct: 428 TKVSRHASSSPESPKPAPAPGSHR-----------------------EISSSPTSKNRSH 464

Query: 357 VAKDAHRKATKAPAKQLAQSSALA------SLTGLGGLGGYGSGDSEDERSDRGSES-SD 409
                 +  +  P++++ +S + A      S +      G+    S   R  R ++    
Sbjct: 465 GRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGR 524

Query: 410 TDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLL 469
           +   + R R R  Q   W + +  Q          + ++ R  +  +        S S  
Sbjct: 525 SRSPQRRGRSRSPQRPGWSRSRNTQ-------RRGRSRSARRGRSHSRSPATRGRSRSRT 577

Query: 470 EAREADGDVVNEKKRTP----NETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNS--- 522
            AR         + RTP    + + +    +   +   ++GRSRS + +   S + S   
Sbjct: 578 PARRG-----RSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVR 632

Query: 523 -RTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIK 581
            R+ S S    S    S + + R  SRS +P R+ R SRSR+P  ++ RSRSR+ +RR +
Sbjct: 633 RRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGR-SRSRTPARRSGRSRSRTPARRGR 691

Query: 582 IESN---RARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRT---------- 628
             S    R R + R   R  R+     +RR RS S   R+++SR+  RR+          
Sbjct: 692 SRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKK 751

Query: 629 ----NRASRSRSRDRRKIDDQ---RGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKD 681
               +R SRS S  R K   +   R +LSG+S   K +++   R+     S  K + +  
Sbjct: 752 SRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTP 811

Query: 682 KEREREQDKRKEKQKRE---EKDFKFSSQDDRLKR---KRESERTFSRSGSISVKIIRHD 735
             R R       KQK +    +    SS   ++K     R+   T  ++   SV   R  
Sbjct: 812 PRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRS 871

Query: 736 SRQDSK----KSTTKDSKKHSGSD------------SSGRSSSESPGSSKEKKAKKPKHS 779
             + S     KS T      SGS             S  RSSS  P        ++  HS
Sbjct: 872 CFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHS 931

Query: 780 RSRSVEKSQRSGKKASRKHKSKS 802
            S S   S+ + +   R+ +S S
Sbjct: 932 GSSSPSPSRVTSRTTPRRSRSVS 954



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 70/179 (39%), Positives = 90/179 (50%), Gaps = 31/179 (17%)

Query: 483  KRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGS 542
            KR P+ T +  E  +E +  E     R   SSS SSSS+S +SS+SS+ SSSS SSSS S
Sbjct: 2577 KRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2636

Query: 543  SRTSSRSSS----------------------PKRKKRHSRS-RSPTIKARRSRSRSYSRR 579
            S +SS SSS                      P   +R SRS R P    R SRS SYS  
Sbjct: 2637 SSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYS-- 2694

Query: 580  IKIESNR--ARVKIRDRRRSN--RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRS 634
              +E  R   +   RD++ S+  R S   +R  +RSPS +RRR     R  R +R+SRS
Sbjct: 2695 -PVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMR-HRSSRS 2751



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 103/408 (25%), Positives = 152/408 (37%), Gaps = 74/408 (18%)

Query: 471  AREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQ---GRSRSGSS-------------- 513
            +R      +N K  TP    S  E   + K   +     RSRSGSS              
Sbjct: 1497 SRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQER 1556

Query: 514  ----SSGSSSSNSRT-------SSTSSTVSSSS----YSSSSGSS-------RTSSRSSS 551
                SS  S + +RT       S +S  V S S      S SGSS       R + R+ S
Sbjct: 1557 SESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQS 1616

Query: 552  PKRKKRHSRSRSPTIKARRSRSRSYSR--------RIKIESNRAR-VKIRDRRRSNRNSI 602
                    ++ +P    RRSRS S S+            ES+     K R  RR +R+S 
Sbjct: 1617 GSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSP 1676

Query: 603  ERERRRNRSPSRER---------------RRSRSRSRDRRTNRASRSRSRDRRKIDDQRG 647
            E  + ++R+P R R               RRSRS S    T   +  R R    +     
Sbjct: 1677 E-PKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEP 1735

Query: 648  NLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQ 707
                 S + +  A     K    R      K +  +R R + +R++ +    +D   SSQ
Sbjct: 1736 AEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQ 1795

Query: 708  DD--RLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSES- 764
                R +R R   R   R    S    R  +RQ+S +++++  +  S +  + R  S S 
Sbjct: 1796 STSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSR 1855

Query: 765  ----PGSSKEKKAKKPKHSRSRS---VEKSQRSGKKASRKHKSKSRSR 805
                P      +A    H RSRS   +   +RS  + S   + +SRSR
Sbjct: 1856 TSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSR 1903



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 117/512 (22%), Positives = 176/512 (34%), Gaps = 94/512 (18%)

Query: 185  QPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKME 244
            +P  P P A P+  R   SS + R  SP      +  P+    K RT     R G     
Sbjct: 1623 EPKAPAPRALPRRSRSGSSS-KGRGPSPEGSSSTESSPE-HPPKSRTA----RRGSRSSP 1676

Query: 245  REKQKKLEKERMEQQRS--QLSKKEKKATEDAEGGDGP-----------RLPQRSKFDSD 291
              K K     R    RS  +L++K + +         P           R P  S  +  
Sbjct: 1677 EPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPA 1736

Query: 292  EEEEDTENVEAASSGKVT------RSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEI 345
            E+   +    +ASS +        RSPSP P+        +  EK               
Sbjct: 1737 EKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTR------------- 1783

Query: 346  LLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGS 405
                         +   R  +     +  Q S   S       GG G       RS    
Sbjct: 1784 -----------TTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGY----HSRSPARQ 1828

Query: 406  ESSDTDDEELRHRIR-----------QKQEAFWRKEKEQQ--LLHDKQMEE----EKQQT 448
            ESS T     R R R           +   A W++ + +     H +         ++++
Sbjct: 1829 ESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRS 1888

Query: 449  ERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS 508
               T  ++    + + S++   +R     V   ++R+ + T  V   +   +    + RS
Sbjct: 1889 RSRTSPVSRRRSRSRTSVTRRRSRSRASPV--SRRRSRSRTPPVTRRRSRSRTPTTRRRS 1946

Query: 509  RSGSSSSGSSSSNSRT---------------------SSTSSTVSSSSYSSSSGSSRTSS 547
            RS +       S SRT                     S TS      S S +S  +R  S
Sbjct: 1947 RSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRS 2006

Query: 548  RSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERR 607
            RS +    +R SRSR+P    RRSRSR+     K   +R+ + IR R RS      R +R
Sbjct: 2007 RSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKR 2066

Query: 608  R-NRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
               RSP   RRRS S S   R+  A+   +R+
Sbjct: 2067 SLTRSPPAIRRRSASGSSSDRSRSATPPATRN 2098



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 82/392 (20%), Positives = 141/392 (35%), Gaps = 43/392 (10%)

Query: 442 EEEKQQTERVTK-----EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
           EE   Q   VT+     E+NE  ++   +   +     DG   + ++R         EP 
Sbjct: 109 EETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPP 168

Query: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556
           K +    +   SRS +               S + S       S   +     S  K++K
Sbjct: 169 KPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRK 228

Query: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616
                RSPT K++R      S+  K + +R+       RR++R++       + + S + 
Sbjct: 229 H----RSPTPKSKRK-----SKDKKRKRSRSTTPAPKSRRAHRST-----SADSASSSDT 274

Query: 617 RRSRSRSRDRRTNRA-----SRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSR 671
            RSRSRS   +T+       S S +  RR   D   +  G +   +  + E   K+  S 
Sbjct: 275 SRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSP 334

Query: 672 SIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDR-----------------LKRK 714
             DKD+ KK+K   R     +      E         +R                 +   
Sbjct: 335 YEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPP 394

Query: 715 RESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK--KHSGSDSSGRSSSESPGSSKEKK 772
            E+  T  RS   S + +   S  +S   + + +K  +H+ S       + +PGS +E  
Sbjct: 395 SEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS 454

Query: 773 AKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
           +     +RS    K  +S      +   +SRS
Sbjct: 455 SSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRS 486



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 64/221 (28%), Positives = 83/221 (37%), Gaps = 54/221 (24%)

Query: 504  KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSS----------RTSSRSSSPK 553
            K+ RS S SSSS SSSS+S +SS+SS+ S SS S S GSS          R  S + +PK
Sbjct: 2528 KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587

Query: 554  RKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSI----------- 602
               R  R   PT   R+ RS S S      S+ +         S+ +S            
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647

Query: 603  ------------------------ERERRRNRSPSRERRRSRS---------RSRDRRTN 629
                                    ER  R  R P    R SRS         R   + + 
Sbjct: 2648 SPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSP 2707

Query: 630  RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
            R  +S S +R     QRG+    SHK + E       + RS
Sbjct: 2708 RDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRS 2748



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 77/304 (25%), Positives = 116/304 (38%), Gaps = 27/304 (8%)

Query: 514  SSGSSSSNSRTSSTSSTVSSSSYSSSS----GSSRTSSRSSSPKRKKRHSRSRSPTIKAR 569
            SSG SSS     +      SS+ S SS       RT SR  S        +   P   +R
Sbjct: 1378 SSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSR 1437

Query: 570  RSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTN 629
            RSRS S S  ++  S          R S   S    +   R+PSR R    S    +   
Sbjct: 1438 RSRSGS-SPGLRDGSG------TPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALP 1490

Query: 630  RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
            +  R RSR       +  N      + +  ++    +K  +R+    R +    +E +  
Sbjct: 1491 QTPRPRSRS--PSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVK 1548

Query: 690  KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGS---------ISVKIIRHDSRQDS 740
                 Q+R E D   SS D + K  R   R  SRSGS         +S +  R  S  + 
Sbjct: 1549 PSASPQERSESD---SSPDSKAK-TRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEV 1604

Query: 741  KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKS 800
            K       +  SGSDSS    + +P  +  ++++    S+ R       S  ++S +H  
Sbjct: 1605 KDKPRAAPRAQSGSDSSPEPKAPAP-RALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPP 1663

Query: 801  KSRS 804
            KSR+
Sbjct: 1664 KSRT 1667



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 63/283 (22%), Positives = 105/283 (37%), Gaps = 25/283 (8%)

Query: 487  NETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS---SNSRTSSTSSTVSSSSYSSSSGSS 543
            N   SV  P   H +  +   S      S  ++   +  R SS+SS+ SSSS SSSS SS
Sbjct: 2491 NGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSS 2550

Query: 544  RTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIE 603
             +SS S S                   S S S    + ++   A  ++     + + ++ 
Sbjct: 2551 SSSSSSGS-------------------SSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVR 2591

Query: 604  RERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQ 663
              R    +P++ +RRS S S    ++ +S S S           + S +S      +   
Sbjct: 2592 EGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSP 2651

Query: 664  ERKKERSRSIDKDRKKKDKEREREQDKRKE-KQKREEKDFKFSSQDDRLKRKRESERTFS 722
             +   ++       KK      R +  RK     R+ +   +S  + R    + S R   
Sbjct: 2652 AKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPR--D 2709

Query: 723  RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESP 765
            +  S S +  R   R DS+  + K  ++          SS SP
Sbjct: 2710 QQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 93/429 (21%), Positives = 161/429 (37%), Gaps = 43/429 (10%)

Query: 403  RGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE 462
            RG   S T     R     +++   R  + +   +     ++ + + R ++ ++    K 
Sbjct: 710  RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKA 769

Query: 463  QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNS 522
            ++ LSL  +         +K +TP   +     + + K +    RSRS SS        S
Sbjct: 770  KSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSP--PPKQKS 827

Query: 523  RTSSTSSTVSSSSY----------SSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKAR--R 570
            +T S  S  SSS +            S  S + + +S +P+R+     S  P +K+R   
Sbjct: 828  KTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPS 887

Query: 571  SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIE-----RERRRNRSPSRERRRSRSRSRD 625
              S S S   +++S+    +   R  S +  ++     R+R  + S S    R  SR+  
Sbjct: 888  RHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTP 947

Query: 626  RRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERE 685
            RR+   S   + + R +   R + SG+S        E   ++  S SI    K K +   
Sbjct: 948  RRSRSVSPCSNVESRLL--PRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPP 1005

Query: 686  RE--QDKRKEKQKREEKDFKFSSQDDRL------KRKRESERTFSRSGSISVKIIRHDSR 737
                   +    + + KD    S    L      K       ++    S+ +K       
Sbjct: 1006 GPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLK------- 1058

Query: 738  QDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRS----VEKSQRSGKK 793
               +  T+ D +  + S    +S SESP S + K    PK  RSRS     E + RS  +
Sbjct: 1059 --GQSQTSPDHRSDTSSPEVRQSHSESP-SLQSKSQTSPKGGRSRSSSPVTELASRSPIR 1115

Query: 794  ASRKHKSKS 802
              R   S S
Sbjct: 1116 QDRGEFSAS 1124



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/79 (37%), Positives = 40/79 (50%), Gaps = 7/79 (8%)

Query: 507  RSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS-------SSSGSSRTSSRSSSPKRKKRHS 559
            RSRS S  +    S SRT  T+    S + S       S+SGSS   SRS++P   + HS
Sbjct: 2041 RSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHS 2100

Query: 560  RSRSPTIKARRSRSRSYSR 578
             SR+P +    SR   +SR
Sbjct: 2101 GSRTPPVALNSSRMSCFSR 2119



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 29/94 (30%), Positives = 38/94 (40%), Gaps = 6/94 (6%)

Query: 712  KRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK 771
            KRKR S  + S S S S       S   S  S++  S   S S SS  SSS SP  +K  
Sbjct: 2602 KRKRRSSSSSSSSSSSS------SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG 2655

Query: 772  KAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
                PK +  +     +R  +   +   S   SR
Sbjct: 2656 PQALPKPASPKKPPPGERRSRSPRKPIDSLRDSR 2689



 Score = 37.4 bits (85), Expect = 0.056
 Identities = 50/226 (22%), Positives = 84/226 (37%), Gaps = 18/226 (7%)

Query: 483  KRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSY-----S 537
            + TP  + SV  P    + +     S SGSSS  +          S + S S Y      
Sbjct: 944  RTTPRRSRSV-SPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ 1002

Query: 538  SSSGSSRTSSRSSSPKRKKRHSRSRS--------PTIKARRSRSRSYSRRIKIESNRARV 589
            +  G S + S+S  P+ K + S  +S          +K+      SY     ++  + + 
Sbjct: 1003 TPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQL-KGQS 1061

Query: 590  KIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNL 649
            +     RS+ +S E  +  + SPS + +   S    R  + +  +    R  I   RG  
Sbjct: 1062 QTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEF 1121

Query: 650  SGNSHKHKGEAKEQERKKERSRS---IDKDRKKKDKEREREQDKRK 692
            S +     G + EQ R +  S S   +D +        E  + K K
Sbjct: 1122 SASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK 1167



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 27/77 (35%), Positives = 39/77 (50%), Gaps = 8/77 (10%)

Query: 736  SRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSS---KEKKAKKPKHSRSRSVEKSQRSGK 792
            S   S  S++  S   S S SSG SSS+S GSS   + + A K   S + + +++ R G+
Sbjct: 2535 SSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGR 2594

Query: 793  -----KASRKHKSKSRS 804
                  A RK +S S S
Sbjct: 2595 PPEPTPAKRKRRSSSSS 2611


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  108 bits (269), Expect = 3e-23
 Identities = 107/373 (28%), Positives = 155/373 (41%), Gaps = 71/373 (19%)

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552
           L PK + K++EK+    S SSSS SS S+S + S S        SS S  S +++   S 
Sbjct: 177 LIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQS--------SSDSSDSESATEEKSK 228

Query: 553 KRKKRH---SRSRSPTIKARRSRSRSYSRRIKIESNRAR--------------------- 588
           KRKK+H   SR      K R+   +S S   + E+  A+                     
Sbjct: 229 KRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMR 288

Query: 589 ---VKIRDRRRSNRNSIERERRRNRSP------SRERRRSRSRS-------RDRRTNRAS 632
               K  ++ R NR   ERER R  +P      S +RR   +RS         RR    S
Sbjct: 289 KSPPKADEKERKNR---ERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPS 345

Query: 633 RSRSRDRRKIDD------------QRGNLSGNSHKHKGEAKEQERKKERSRS--IDKDRK 678
           RSRSRDR +  +            QR  +S      KG+  E    KE  RS    K+RK
Sbjct: 346 RSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK 405

Query: 679 KKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQ 738
             D     E   RK +++++ KD K +S++  ++R  E +  +        K       +
Sbjct: 406 ITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSK 465

Query: 739 DSKKSTTKDSK------KHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGK 792
           +  KS  +DSK      K   S S GR         K+  +K     RSRS EKS++   
Sbjct: 466 EKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLES 525

Query: 793 KASRKHKSKSRSR 805
           K++    SKS+ +
Sbjct: 526 KSNEHDHSKSKEK 538



 Score =  105 bits (261), Expect = 2e-22
 Identities = 129/586 (22%), Positives = 230/586 (39%), Gaps = 57/586 (9%)

Query: 241 EKMEREKQKKLEKERMEQQRSQLSK----------KEKKATEDAEGGDGPRLPQRSKFDS 290
           E + + K KK EK+R +   S  S           +    + D+E     +  +R K   
Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHR 235

Query: 291 DEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVT 350
               +  +  +     K + S     +   + P+ T   +E   +   + L+ +      
Sbjct: 236 KNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKAD 295

Query: 351 DEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDT 410
           ++E     ++  R+    P  Q A       +T         SG     R  R   +   
Sbjct: 296 EKERKNRERERERECNP-PNSQPASYQRRLLVTR--------SGRKIKGRGPRRYRTPSR 346

Query: 411 DDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLE 470
                R R R +    WR+E   Q     ++   ++  +    E+NE    +++ + + E
Sbjct: 347 SRSRDRFR-RSETPPHWRQE--MQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKE 403

Query: 471 AREADGDVVNEKKRTPNETTS-VLEPKKEHKEK------EKQGRSRSGSSSSGSSSSNSR 523
            +  D   V+E     NE    V + K   KE+      EK  + ++       S S S+
Sbjct: 404 RKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSK 463

Query: 524 TSSTSSTVSSSSYSSSSGSSRTSSRSSSPKR---KKRHSRSRSPTIKARRSRSRSYSRRI 580
           +   S +    S  + +   R  SRS        K++  +S S      RSRS+  S+++
Sbjct: 464 SKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQL 523

Query: 581 KIESNR---ARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSR 637
           + +SN    ++ K +DRR  +R S E +  + +     R R RSRSRDR     SR+  R
Sbjct: 524 ESKSNEHDHSKSKEKDRRAQSR-SRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDR 582

Query: 638 DRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKK-----KDKEREREQDKRK 692
           DR +  +         ++ +G ++ +ER+    RS  KDR++     +  ERE  Q + K
Sbjct: 583 DRSRSKEYH-RYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNK 641

Query: 693 EKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS 752
           +K + +E     S    R +     +R +S+S         H+S  +S++   K  +  S
Sbjct: 642 DKYRNQE-----SKSSHRKENSESEKRMYSKSRD-------HNSSNNSREK--KADRDQS 687

Query: 753 GSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKH 798
                 +SS ++   S   K K+ +  RS SVEK  +  K     H
Sbjct: 688 PFSKIKQSSQDNELKSSMLKNKEDEKIRS-SVEKENQKSKGQENDH 732



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 111/467 (23%), Positives = 188/467 (40%), Gaps = 65/467 (13%)

Query: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVT 452
           S  S+ + S     SSD+ D E     + K+    +K ++    H K+ ++ K+  +  +
Sbjct: 199 SSSSDSDSSSDSQSSSDSSDSESATEEKSKKRK--KKHRKNSRKHKKEKKKRKKSKKSAS 256

Query: 453 KEMNEFIHKEQNSLSLLEAREADGDVVNE--KKRTPNETTSVLEPKKEHKEKEKQGRSRS 510
            E +E  + E    S +   E      N    +++P        PK + KE++ + R R 
Sbjct: 257 SE-SEAENLEAQPQSTVRPEEIPPIPENRFLMRKSP--------PKADEKERKNRERERE 307

Query: 511 GSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSS-RTSSRSSSPKRKKRHSRS---RSPTI 566
              +  +S   S       T S            RT SRS S  R +R       R    
Sbjct: 308 RECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQ 367

Query: 567 KARRSRSRSYSRRIK---------IESNRARVKIRDRRRSNRNSIERERRRNRSPSRERR 617
           +A+R R  S  R IK          E+ R+ V++++R+ ++  ++     R     ++ +
Sbjct: 368 RAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVK 427

Query: 618 RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQ-------ERKKERS 670
             +S S++R   R S    + + K+  +  + S +  K K ++KE+       E K+ RS
Sbjct: 428 DHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRS 487

Query: 671 RSIDKDR------------KKKDKEREREQDKRKE-KQKREEKDFKFSSQDDRLKRKRES 717
           RS  +D             K KD+ER R ++K K+ + K  E D   S + DR  + R  
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547

Query: 718 E----------------RTFSRSGSISVKIIRHDSRQDSKKS--TTKDSKKHSGSDSSGR 759
           E                R+ SR  S  V+   HD  +   K     ++ +      S  R
Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSR 607

Query: 760 SSSESPGSSKEK-KAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
                PG S+ K + ++ + SRS   E+SQ   K   R  +SKS  R
Sbjct: 608 ERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHR 654



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 126/594 (21%), Positives = 228/594 (38%), Gaps = 106/594 (17%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDA-----VKRRTLPAWIREGLEKMEREKQKK 250
           +N R+     + R++S  +   + E   ++A     V+   +P  I E    M +   K 
Sbjct: 236 KNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPP-IPENRFLMRKSPPKA 294

Query: 251 LEKERMEQQR----------SQLSKKEKKATEDAEG----GDGPR---LPQRSKFDSDEE 293
            EKER  ++R          SQ +  +++      G    G GPR    P RS+      
Sbjct: 295 DEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFR 354

Query: 294 EEDT-----ENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLD 348
             +T     + ++ A   +V+     +  ++    E+ E ++    +   K         
Sbjct: 355 RSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK--------- 405

Query: 349 VTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESS 408
           +TD          HR  +++P ++  +   +               +S++    R SE  
Sbjct: 406 ITD----------HRNVSESPNRKNEKEKKVKD----------HKSNSKERDIRRNSEKD 445

Query: 409 DTDDEELRHRIRQKQEAFWR---KEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNS 465
           D    +++ R + K  +  +   K KE+   H++   EEK+   R     +E + KE+  
Sbjct: 446 DKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRN--EEKRMRSRSKGRDHENV-KEKEK 502

Query: 466 LSLLEAREADGDVVNEK-KRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRT 524
            S  + ++ +     EK K+  +++      K + K++  Q RSR    + G  S NSRT
Sbjct: 503 QSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRT 562

Query: 525 SSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIES 584
              S              SR  SR     R + H R RS + +  R R + Y R      
Sbjct: 563 RERS-------------RSRDRSRR---VRSRTHDRDRSRSKEYHRYREQEYRR------ 600

Query: 585 NRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDD 644
            R R + R+RR     S  ++RRR R  SR   R  S+SR++   R   S+S  R++  +
Sbjct: 601 -RGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSE 659

Query: 645 QRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKF 704
               +   S  H      +E+K +R +S     K+  ++ E +    K K          
Sbjct: 660 SEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNK---------- 709

Query: 705 SSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSG 758
             +D++++   E E   S+          +D   +  K    +S   +  D SG
Sbjct: 710 --EDEKIRSSVEKENQKSKGQ-------ENDHVHEKNKKFDHESSPGTDEDKSG 754



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)

Query: 713 RKRESERTFSRSGSIS-VKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK 771
           R+ E+++T + S   + V+I+         K   ++ K+H  S SS  SSS+S  SS  +
Sbjct: 152 REIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQ 211

Query: 772 KAKKPKHSRSRSVEKSQRSGK---KASRKHKSKSRSR 805
            +     S S + EKS++  K   K SRKHK + + R
Sbjct: 212 SSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKR 248



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 34/123 (27%), Positives = 50/123 (40%), Gaps = 13/123 (10%)

Query: 682 KEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSK 741
           +E E ++     K   E +         + K K+E ++    S S S      DS  DS+
Sbjct: 152 REIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQ 211

Query: 742 KSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSK 801
                     S SDS   S SES    K KK KK     SR  +K ++  KK+ +   S+
Sbjct: 212 ----------SSSDS---SDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSE 258

Query: 802 SRS 804
           S +
Sbjct: 259 SEA 261


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score =  106 bits (265), Expect = 7e-23
 Identities = 111/438 (25%), Positives = 182/438 (41%), Gaps = 51/438 (11%)

Query: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVT 452
           S D  D RS R  ++ D  D E R   R K++ +  + +     H   + EE  +TE   
Sbjct: 492 SRDPRDSRSTR--DAHDYRDREGRDTHR-KEDTYPEESRSYGRNH---LREESSRTEIRN 545

Query: 453 KEMNEFIHKEQNS-----------LSLLEAREADGDVVNEKKRTPN-----ETTSVLEPK 496
           +  NE   + +N            L    +R + G  ++      N     ET S    +
Sbjct: 546 ESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPER 605

Query: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556
             + E++ + ++R  S        + R +       SS         R   R+   +R +
Sbjct: 606 DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPI-------RHQGRNDELERDE 658

Query: 557 RHSRSRSPTIKARR---SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPS 613
           R    R   +  RR   +R R   R    E  R R + RDR R     +ERER R R   
Sbjct: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERE 718

Query: 614 RERRRSRSRSRDRRTNRA-SRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRS 672
           RE+ R R R RDR  +R   R R RDR K + +R        + +   +E+ER++ER R+
Sbjct: 719 REKERDRERDRDRDHDRERERERERDREK-EREREREERERERERERERERERERERERA 777

Query: 673 IDKDRKKKDKEREREQD-KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKI 731
                +++DKERER++D + K+K + + ++ +   ++DR  R    ER        S K 
Sbjct: 778 -----RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERK-------SKKR 825

Query: 732 IRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRS----VEKS 787
            R++     ++S  +  +    SD+      ++       +  +P+ SRS S     E  
Sbjct: 826 YRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDR 885

Query: 788 QRSGKKASRKHKSKSRSR 805
           Q   K+  RK + K  SR
Sbjct: 886 QGRWKEEDRKPERKESSR 903



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 121/600 (20%), Positives = 220/600 (36%), Gaps = 60/600 (10%)

Query: 242  KMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPR--LPQRSKFDSDEEEEDTEN 299
            K +REK  + E+E  + Q S    ++ +   D       R    +R   DS +  +  E 
Sbjct: 423  KRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREM 482

Query: 300  VEAASSGKVTRSP----SPVPQEEHSDPE----------MTEEEKEY-QMMLLTKMLLTE 344
             + +   K +R P    S     ++ D E            EE + Y +  L  +   TE
Sbjct: 483  RDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542

Query: 345  ILLDVTDEEIYYVAKD----AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDER 400
            I  +  +E    +  D    +  +  + P K  ++ S  + +        Y   DS + R
Sbjct: 543  IRNESRNESRSEIRNDRMGRSRGRVPELPEKG-SRGSRGSQIDSHSSNSNYH--DSWETR 599

Query: 401  S-----DRGSESSDTDDE-----ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER 450
            S     DR  E  + D       E RH  R +++   R ++    +  +   +E ++ ER
Sbjct: 600  SSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER 659

Query: 451  VTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRS 510
              +   + +   ++  +    RE + D   E++R   E     E ++E + +  + R R 
Sbjct: 660  REERRVDRVDDRRDERARERDRERERDRERERERE-RERDREREKERELERERARERERE 718

Query: 511  GSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARR 570
                        R                        R    +R++   R R    +  R
Sbjct: 719  REKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR 778

Query: 571  SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNR 630
             R +   R+   E    + K RD RR  R  I  +R  N     + R+S+ R R+  +  
Sbjct: 779  ERDKERERQRDWED---KDKGRDDRREKREEIREDR--NPRDGHDERKSKKRYRNEGSPS 833

Query: 631  ASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID-----KDRKKKDKERE 685
              +S  R R    D     SG+    K     Q  + + SRS+      +DR+ + KE +
Sbjct: 834  PRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEED 893

Query: 686  REQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRH---------DS 736
            R+ ++++  ++ EE++ K   +   + ++RE       S   +  II H         D 
Sbjct: 894  RKPERKESSRRYEEQELK--EKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR 951

Query: 737  RQDSKKSTTKDSK---KHSGSDSSGRSSSESPGSSKEKKAKKPKH-SRSRSVEKSQRSGK 792
              D  K   K  K   K    D  G        +S++ +   PK   + +S+EK ++  K
Sbjct: 952  AHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSK 1011



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 72/321 (22%), Positives = 136/321 (42%), Gaps = 29/321 (9%)

Query: 395  DSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKE 454
            + E +R        D + E  R R R+K+    R+E+E++   +++ E E+++     +E
Sbjct: 720  EKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE 779

Query: 455  MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSS 514
             +    KE+      E ++   D   EK+    E  +   P+  H E++ + R R+  S 
Sbjct: 780  RD----KERERQRDWEDKDKGRDDRREKREEIREDRN---PRDGHDERKSKKRYRNEGSP 832

Query: 515  SGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-------- 566
            S   S   R   +  + + +S    +   R  S+   P+     SRS SP+         
Sbjct: 833  SPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQE----SRSLSPSHLTEDRQGR 888

Query: 567  ---KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRS----PSRERRRS 619
               + R+   +  SRR + +  + +V   D++R     +E  R R +        E R +
Sbjct: 889  WKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRET 948

Query: 620  RSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKK-ERSRSIDKDRK 678
              R+ D    +A   +   ++K +D  G   GN      + +    KK ++ +SI+K RK
Sbjct: 949  SDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRK 1008

Query: 679  KK--DKEREREQDKRKEKQKR 697
            K   D +   E+  ++ K+KR
Sbjct: 1009 KSKGDSDISDEEAAQQSKKKR 1029



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 138/708 (19%), Positives = 276/708 (38%), Gaps = 135/708 (19%)

Query: 193  APPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLE 252
            A  + R       R+R R       ++   + D  K R      RE   + ERE++++ E
Sbjct: 712  AREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERE 771

Query: 253  KERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSP 312
            +ER   +     ++ ++  ED + G   R  +R +   D    D  + E  S  +     
Sbjct: 772  RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHD-ERKSKKRYRNEG 830

Query: 313  SPVPQE------EHS---DPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
            SP P++      EHS   D   + ++K  +  LL++++  +    ++   +    +   +
Sbjct: 831  SPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWK 890

Query: 364  KATKAPA---------------------KQLAQSSALAS--LTGLGGLGGYGSGDSE--- 397
            +  + P                      KQ  Q+  L S  +     +G + S D E   
Sbjct: 891  EEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSD 950

Query: 398  -----------------------DERSDRGS-ESSDTDDEELRHRIRQKQEAFWRKEKEQ 433
                                   D   +RG+ E++  D +    +  QK+++  +K K+ 
Sbjct: 951  RAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS 1010

Query: 434  QLLHDKQMEEEKQQTER----------VTKEMNEFIHKEQNSLSLLEARE-------ADG 476
            +   D   EE  QQ+++            +E+ E  + +   L   + +E       +D 
Sbjct: 1011 KGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDE 1070

Query: 477  DV-----VNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTV 531
            DV     V E + T   TT    P              + ++++  ++  + T++ +++ 
Sbjct: 1071 DVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSF 1130

Query: 532  SSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSR-SRSYSRRIKIESNRARVK 590
            S+S+ + S+ ++ T++ +++   +  H        K  R+R  +  +  + IE  + R  
Sbjct: 1131 STSAITISTSATPTNTTNNTFANEDSHR-------KCHRTRVEKVETPHVTIEDAQHRKP 1183

Query: 591  IRDRRRS----NRNSIERERRRNRSPSRE------------RRRSRSRSRDRRTNRASRS 634
            +  +R S    NR++      R RSPS +            +R   S SRDR   ++   
Sbjct: 1184 MDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEI 1243

Query: 635  RSRDRRKIDD-QRGNLS---------GNSHKHKGEAKEQERK--------KERSRSIDKD 676
                + +ID  +RG  S           SH  +  + E +R+          R R  ++D
Sbjct: 1244 TGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERD 1303

Query: 677  RKKKDKEREREQ--DKRKEKQKREEKDFKFSSQDDRLK---------RKRESERTFSRSG 725
            R + D+ERERE+   +++E  +  +KD+  +   DRL+         ++R+ +R   R  
Sbjct: 1304 RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLI 1363

Query: 726  SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKA 773
            S SV+  R   R  + +S+  +S K   +   G    +   +S++  A
Sbjct: 1364 SDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLA 1411



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 89/404 (22%), Positives = 159/404 (39%), Gaps = 42/404 (10%)

Query: 416 RHRIRQKQEAFWRKEKEQQLLHDK-----QMEEEKQQTERVTKEMNEFIHKEQNSLSLLE 470
           +  + +++E   +KE   +++  K      + +  +  +R +   +    K+    S + 
Sbjct: 182 QENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVS 241

Query: 471 AREAD---GDVVNEKK----RTPNETTSVLEP---KKEHKEKEK-----QGRSRSGSSSS 515
           +   D       N+ K    RTP+    + E     K++KEK K     + ++R G    
Sbjct: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG 301

Query: 516 GS-SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSR 574
                   +     ST  +  + S   S   SS S S    +RHS    P+ + +R+ S 
Sbjct: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHS----PSPRRKRTPSP 357

Query: 575 SYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRS 634
           SY R +     R+         S+        +R +SP R R   R + R     R S+S
Sbjct: 358 SYQRTLTPPLRRSASPYPSHSLSS-------PQRKQSPPRHRSPMREKGRHDH-ERTSQS 409

Query: 635 RSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKD-KEREREQDKRKE 693
             R   + +D RG    +  K   E +E E+ +  SR    DR+ +D ++R   +D R  
Sbjct: 410 HDRRHERREDTRG--KRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDR 467

Query: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSR-QDSKKSTTKDSKKHS 752
           ++ R+ +D + S +     R  +  R    S S       HD R ++ + +  K+     
Sbjct: 468 RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR---DAHDYRDREGRDTHRKEDTYPE 524

Query: 753 GSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASR 796
            S S GR+      S  E   +    + SRS  ++ R G+   R
Sbjct: 525 ESRSYGRNHLREESSRTE--IRNESRNESRSEIRNDRMGRSRGR 566



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 90/327 (27%), Positives = 131/327 (40%), Gaps = 76/327 (23%)

Query: 481  EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS 540
            EK  TP+ T   +E  +  K  +++  S  GS+ S  S ++ R  S S+  +  S    S
Sbjct: 1166 EKVETPHVT---IEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQS 1222

Query: 541  GSSR-----------------TSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIE 583
            G  R                 T  R S   + KR   SRS +   + SRS S SRR   E
Sbjct: 1223 GRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS-SRRSSPE 1281

Query: 584  SNRA------------RVKIRDRRRSNRNSIERERRRNRSPSRE----------RRRSRS 621
            S+R             R++ RDR   +R   ERER R  +  RE          R R R 
Sbjct: 1282 SDRQVHSRSGSFDSRDRLQERDRYEHDR---ERERERRDTRQREWDRDADKDWPRNRDRD 1338

Query: 622  RSRDRRTNRASRSRSRD-RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKK 680
            R R+R      R R RD RR +D +R  L  +S              ER R  D+DR  +
Sbjct: 1339 RLRER-----ERERERDKRRDLDRERERLISDS-------------VERDRDRDRDRTFE 1380

Query: 681  DKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS 740
              + E  +    + +   E+D + +S+D     K   ER     GS+          +++
Sbjct: 1381 SSQIESVKRCEAKLEGEHERDLESTSRDSLALDK---ERMDKDLGSV-------QGFEET 1430

Query: 741  KKSTTKDSKKHSGSDSSGRSSSESPGS 767
             KS   +S + +G D S    + S GS
Sbjct: 1431 NKSERTESLE-AGDDESKLDDAHSLGS 1456



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 125/649 (19%), Positives = 230/649 (35%), Gaps = 115/649 (17%)

Query: 236 IREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEE 295
           +RE ++   ++   + +K   E+  S + +KE       E  D     +R+    +E  E
Sbjct: 85  LRERMKNKRQDVDTEPQKRNTEESSSPV-RKESSRGRHREKEDIKITKERTPESEEENVE 143

Query: 296 DTENVEAASSGKVT----RSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTD 351
              N + + +G +        S   + +    E+ + E+E        ++  E+  +V  
Sbjct: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203

Query: 352 EEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTD 411
            ++      + RK++K+P ++ +  S+ AS               +D ++   + SS   
Sbjct: 204 SKLS--PSPSLRKSSKSPKRKSSPKSSSAS--------------KKDRKTS--AVSSPLL 245

Query: 412 DEELRHRIRQKQEAFWRKEKE-----QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSL 466
           D++   +  Q ++   R         + +   K+ +E+ +  +R+ ++  +         
Sbjct: 246 DQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDG-------- 297

Query: 467 SLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSS 526
              + R  D +   EK+  P  T+    P  +H       R  S SS SGSS      S 
Sbjct: 298 ---KDRGRDFERQREKRDKPRSTS----PAGQH-HSPISSRHHSSSSQSGSSIQRHSPSP 349

Query: 527 TSSTVSSSSYSSS-------SGSSRTSSRSSSPKRKKRHSRSRSPTIKARR--------S 571
                 S SY  +       S S   S   SSP+RK+   R RSP  +  R        S
Sbjct: 350 RRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQS 409

Query: 572 RSRSYSRRIKIESNRARVK-----------------------------------IRDRRR 596
             R + RR      R R K                                    RDRR 
Sbjct: 410 HDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRE 469

Query: 597 SNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD----RRKID--DQRGNLS 650
              +   R+ R  R  SR+ + SR     R T  A   R R+     RK D   +     
Sbjct: 470 LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSY 529

Query: 651 GNSHKHKGEAKEQERKKERSRS---IDKDRKKKDKEREREQDKRKEKQKREEKDFKFSS- 706
           G +H  +  ++ + R + R+ S   I  DR  + + R  E  ++  +  R  +    SS 
Sbjct: 530 GRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN 589

Query: 707 ---------QDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSS 757
                    +    +R R  ER  +R  +      R    +D + +  +D +  S     
Sbjct: 590 SNYHDSWETRSSYPERDRYPERD-NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQ 648

Query: 758 GRSSS-ESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GR+   E     +E++  +    R     +  R  ++   + + + R R
Sbjct: 649 GRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERER 697



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 85/414 (20%), Positives = 162/414 (39%), Gaps = 49/414 (11%)

Query: 196  QNRRERPSS-FRDRQRSP-IALPVKQEPPQIDAVK-RRTLPAWIREGLEKMEREKQKKLE 252
            + R +RPSS  R + R+  +    ++E  ++D V  RR   A  R+   + +RE++++ E
Sbjct: 635  RERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERE 694

Query: 253  KER---------MEQQRSQLSKKEKKATEDAE---GGDGPRLPQRSKFDSDEEEEDTENV 300
            +ER         +E++R++  ++E++   D E     D  R  +R +    E+E + E  
Sbjct: 695  RERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE 754

Query: 301  EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDE-EIYYVAK 359
            E     +  R      + E       ++E+E Q     K    +   +  +E       +
Sbjct: 755  ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814

Query: 360  DAH--RKATKAPAKQLAQS---SALASLTGLGGLGGYGSGDSEDERSD------RGSESS 408
            D H  RK+ K    + + S   S             Y SGD ++E+        R  ES 
Sbjct: 815  DGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR 874

Query: 409  DTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSL 468
                  L     + ++  W++E  +     ++ E  ++  E+  KE    + K++    +
Sbjct: 875  SLSPSHL----TEDRQGRWKEEDRK----PERKESSRRYEEQELKEKVSSVDKQREQTEI 926

Query: 469  LE-AREADGDVVNEKKRTPNETTSVLEPKKEHKEK-EKQGRSRSGSSSSGSSSSNSRTSS 526
            LE +R    D++   +    ET+     + + K K +K+   +      G    N  T+S
Sbjct: 927  LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986

Query: 527  TSSTVSS-----------SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKAR 569
                V S                S G S  S   ++ + KK+    R+P I  +
Sbjct: 987  EDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG-PRTPPITTK 1039



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 46/238 (19%), Positives = 97/238 (40%), Gaps = 20/238 (8%)

Query: 572 RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRA 631
           R + YS   +    R    +R+R ++ R  ++ E        ++R    S S  R+ +  
Sbjct: 66  RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTE-------PQKRNTEESSSPVRKESSR 118

Query: 632 SRSRSRDRRKIDDQRGNLSGNSH----KHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
            R R ++  KI  +R   S   +     ++ ++   +   +    +  + K++  +RE  
Sbjct: 119 GRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELM 178

Query: 688 QDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKD 747
           + +++  +KREE   K     + ++ K     +  +S        +   R+ S KS++  
Sbjct: 179 KLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSS-------KSPKRKSSPKSSSAS 231

Query: 748 SK-KHSGSDSSGRSSSESPGSSKEKKAKKPK-HSRSRSVEKSQRSGKKASRKHKSKSR 803
            K + + + SS     +    + + K K P+  S    + +    GKK   K+K K R
Sbjct: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDR 289



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 9/124 (7%)

Query: 687  EQDKRKEKQKREEK-DFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTT 745
            E   RK  + R EK +    + +D   RK   ++   RS S+              +S +
Sbjct: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQK---RSSSLGSNRSNRSHTSGRLRSPS 1210

Query: 746  KDSKKHSGSDSSGRSSSESPGSSKEKKAKK-----PKHSRSRSVEKSQRSGKKASRKHKS 800
             DS   SG D SGR      GS   +K K       + SR   +++ + S   +S +  S
Sbjct: 1211 NDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDS 1270

Query: 801  KSRS 804
            +S S
Sbjct: 1271 RSHS 1274


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score =  101 bits (252), Expect = 2e-21
 Identities = 128/489 (26%), Positives = 207/489 (42%), Gaps = 87/489 (17%)

Query: 238 EGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDT 297
           E + KME   ++    + M+++  Q+ + E++  E  EG    ++ QR     +EE E+T
Sbjct: 276 EQINKMEARPRR----QSMKEKEHQVVRNEEQKAEQEEG----KVAQR-----EEELEET 322

Query: 298 EN----VEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKM------------- 340
            N    VE   +G+       +    HSD E  +EE+E +  +  KM             
Sbjct: 323 GNQHNDVEIEEAGEEEEKEIAIV---HSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQ 379

Query: 341 -LLTEILLDVTD--EEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSE 397
               E ++DV +  E + +V  D     T    + +  S   AS      +      D E
Sbjct: 380 DSQPEEVMDVLEMVENVKHVIADQEVMETNR-VESVEPSENEASKELEPEMEFEIEPDKE 438

Query: 398 DERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNE 457
            +    G E+    D E     ++++E+  + E   Q     Q + + Q   +   +   
Sbjct: 439 CKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQP 498

Query: 458 FIHKEQNSLSLLE----AREADGDVVNEKKRTPNETTSVLE----------PKKEHKEKE 503
               E  SL++L+      +  G ++ E+K  P E+  + E          P+ + K K 
Sbjct: 499 PSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKT 558

Query: 504 K---QGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSG--SSRTSSRSSSPKRKKRH 558
           +   +GR+R+ +S S S SS+S +SS+SST SSS  SSSSG  SSR+SS SSS       
Sbjct: 559 RSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSS 618

Query: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRR 618
             S S T  +  SRSRS  R              +R R +R S++R+RR      R  + 
Sbjct: 619 RDSSSSTSSSSESRSRSRGRG------------HNRDRKHRRSVDRKRRDTSGLERSHKS 666

Query: 619 SR-SRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDR 677
           S+   SRD + ++   SRS  +R I                   E  R  +RS   ++DR
Sbjct: 667 SKGGSSRDTKGSKDKNSRSDRKRSI------------------SESSRSGKRSSRSERDR 708

Query: 678 KKKDKERER 686
           K   K++ R
Sbjct: 709 KSDRKDKRR 717



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 119/630 (18%), Positives = 240/630 (38%), Gaps = 98/630 (15%)

Query: 218 KQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERME----QQRSQLSKKEKKATED 273
           KQ   +I  +   TL  + +E     ER+K+++  ++++E    ++R Q+  + ++  E+
Sbjct: 139 KQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEE 198

Query: 274 --AEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP--VPQEEHSDPEMTEEE 329
             A+  +   L Q+ +    +EE +  N +     +    P    +P       +   EE
Sbjct: 199 RRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEE 258

Query: 330 KEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLG 389
            + +M  L +    E       E+I  +     R++ K    Q+ ++    +    G + 
Sbjct: 259 SQRKMNALFEGRRIEFA-----EQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVA 313

Query: 390 GYGSGDSEDERSDRGSESSDTDDEELRHRI------------RQKQEAFWRKEKEQQLLH 437
                  E+E  + G++ +D + EE                 ++++E   ++E E ++  
Sbjct: 314 -----QREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEE 368

Query: 438 DKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREA-DGDVVNEKKRTPNETTSVLEPK 496
           + ++ E ++Q +   +E+ + +   +N   ++  +E  + + V   + + NE +  LEP+
Sbjct: 369 ETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPE 428

Query: 497 KEHK-EKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSS-----------------SYSS 538
            E + E +K+ +S S    + S+    + S       S                     S
Sbjct: 429 MEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQS 488

Query: 539 SSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSN 598
            S     S   S P+         +P +   +       +   +ES    VK+ +     
Sbjct: 489 QSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVES----VKLTEVPVEP 544

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKG 658
             ++  E       S+ + ++RSRSR R  N+ S+SRSR          + S +S     
Sbjct: 545 VLTVHPE-------SKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSS 597

Query: 659 EAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESE 718
                 R    S S       +D                       SS + R + +    
Sbjct: 598 SGSSSSRSSSSSSSSTSGSSSRDSSSSTS-----------------SSSESRSRSRGRG- 639

Query: 719 RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKH 778
                          H+  +  ++S  +  +  SG + S +SS    GSS++ K  K K+
Sbjct: 640 ---------------HNRDRKHRRSVDRKRRDTSGLERSHKSS--KGGSSRDTKGSKDKN 682

Query: 779 SRS---RSVEKSQRSGKKASRKHKSKSRSR 805
           SRS   RS+ +S RSGK++SR  + +   R
Sbjct: 683 SRSDRKRSISESSRSGKRSSRSERDRKSDR 712



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 72/432 (16%), Positives = 168/432 (38%), Gaps = 42/432 (9%)

Query: 369 PAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWR 428
           PAKQ     A++ L           G+    R  R  + SD +D++++    Q       
Sbjct: 73  PAKQRDLEGAVSRL----------GGERRTRRESR--QESDPEDDDVKKPALQSSVVATS 120

Query: 429 KEKEQQ-LLHDKQMEEE-KQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTP 486
           KE+ ++ L+ D+ M+E+ KQ+  R+   +          +  L+  + +  V  E+++  
Sbjct: 121 KERTRRDLIQDQNMDEKGKQRNRRIFGLL----------MGTLQKFKQESTVATERQKRR 170

Query: 487 NETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTS 546
            E    LE + E + K+ +   R       +  +  R       ++      +  +++  
Sbjct: 171 QEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKII 230

Query: 547 SRSSSPKRKKRHSRSRS-PTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERE 605
                     ++ R+++ P +     R    ++++  ES R    + + RR     IE  
Sbjct: 231 ----------KYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRR-----IEFA 275

Query: 606 RRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQER 665
            + N+  +R RR+S      +      +   ++  K+  +   L    ++H  + + +E 
Sbjct: 276 EQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQH-NDVEIEEA 334

Query: 666 KKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSG 725
            +E  + I       +KE+E E+ K++ + K EE+     S+  +  +  E         
Sbjct: 335 GEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVE 394

Query: 726 SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVE 785
           ++   I   +  + ++  + + S+  +  +       E     KE K+  P      +++
Sbjct: 395 NVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIE-PDKECKSLSPGKENVSALD 453

Query: 786 KSQRSGKKASRK 797
             + S +K  ++
Sbjct: 454 MEKESEEKEEKE 465



 Score = 33.5 bits (75), Expect = 0.81
 Identities = 44/235 (18%), Positives = 98/235 (41%), Gaps = 34/235 (14%)

Query: 592 RDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRT-----NRASRSRSRDRRKIDDQR 646
           R RR S + S   +    +   +    + S+ R RR      N   + + R+RR      
Sbjct: 91  RTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIF---- 146

Query: 647 GNLSGNSHKHKGEA----KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDF 702
           G L G   K K E+    + Q+R++E  + ++   +++ K+ E E+ +  E+++ ++ + 
Sbjct: 147 GLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTEL 206

Query: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQ----------DSKKSTTKDSKKHS 752
           +   Q   L + +E    ++   +  +K IR  ++            + +   ++S++  
Sbjct: 207 RLLEQKVELAQLQEE---WNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKM 263

Query: 753 GSDSSGR--------SSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHK 799
            +   GR        +  E+    +  K K+ +  R+   +  Q  GK A R+ +
Sbjct: 264 NALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEE 318


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score =  100 bits (250), Expect = 4e-21
 Identities = 76/224 (33%), Positives = 116/224 (51%), Gaps = 28/224 (12%)

Query: 490 TSVLEP-KKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSR 548
           ++ +EP KKE K +  + RSRS    + SSS + R+ S S   S S        SR+  R
Sbjct: 234 SAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSK-------SRSRRR 286

Query: 549 SSSPKRKKRHSRSRSPTIKARRSRSRSYSR-RIKIESNRARVKIRDR-----RRSNRNSI 602
           S SP+R++ HSR R      RRSRS S +R + K +  + R K   +     RRS   S 
Sbjct: 287 SKSPRRRRSHSRERG-----RRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASR 341

Query: 603 ERERRRNRSPSRERRRSRS------RSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKH 656
           ER RRR+RS +R  ++ RS      RS   R ++  + + +D+ +  D+R   +    K 
Sbjct: 342 ERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKS 401

Query: 657 KGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEK 700
           K + K++ERK E  + + +  +  D+E   EQ    EK+K+EEK
Sbjct: 402 KDKEKDRERKSESDKDVKQVTRDYDEE---EQGYDSEKEKKEEK 442



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 84/298 (28%), Positives = 137/298 (45%), Gaps = 24/298 (8%)

Query: 491 SVLEPKKEHKEKEKQGRS-RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS 549
           S ++PK  H        S +S +SS     +  R     S +S++         R  SRS
Sbjct: 192 STVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRS 251

Query: 550 SSPKRKKR------HSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIE 603
            S  R++R      H RSRS +   RRS S+S SRR      R R   R+R R +R++  
Sbjct: 252 RSRSRRRRTPSSSRHRRSRSRS--RRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRST-- 307

Query: 604 RERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQ 663
            + R  +   +E++RS++  +   T R SRS SR+RR+   + G  S    K +   ++ 
Sbjct: 308 SKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPK--KPRSPKRKL 365

Query: 664 ERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSR 723
            R     R   + +K KDKER R++ +R   +K++ KD     + DR +RK ES++   +
Sbjct: 366 SRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKD----KEKDR-ERKSESDKDVKQ 420

Query: 724 SGSISVKIIRHDSRQDSKKSTTKDSKK-HSGSDSSGRSSSE--SPGSSKEKKAKKPKH 778
              ++      +   DS+K   ++ K   +GS  +   S E  +  S +E K     H
Sbjct: 421 ---VTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDH 475



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 78/283 (27%), Positives = 127/283 (44%), Gaps = 26/283 (9%)

Query: 520 SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRR 579
           S S  S TSS     +      +    S +  P +K+          K R SRSRS SRR
Sbjct: 207 SPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEE---------KRRHSRSRSRSRR 257

Query: 580 IKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDR 639
            +  S+    + R R R   +S  R RRR++SP   RRRS SR R RR+   S++R + +
Sbjct: 258 RRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSP--RRRRSHSRERGRRSRSTSKTRDKKK 315

Query: 640 RKIDDQRGNLSGNSH----KHKGEAKEQERKKERS--RSIDKDRKKKDKEREREQDKRKE 693
              + +R      S+    + +  ++E+ R++ RS  RS  K R  K K       +R +
Sbjct: 316 EDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHK 375

Query: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
           K+K+++KD K  S+D+R       ER+ S+      K    + + +S K   + ++ +  
Sbjct: 376 KEKKKDKD-KERSRDER-------ERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDE 427

Query: 754 SDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASR 796
            +    S  E     K  +   PK ++  SVEK      + S+
Sbjct: 428 EEQGYDSEKEKKEEKKPIETGSPK-TKECSVEKGTGDSLRESK 469



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 10/243 (4%)

Query: 563 SPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSR 622
           SP++K+  S S+     +K     A+  I      ++   +R   R+RS SR RRR+ S 
Sbjct: 207 SPSLKSDTS-SKEIEEAMK-RVREAQSLISAAIEPDKKEEKRRHSRSRSRSR-RRRTPSS 263

Query: 623 SRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK 682
           SR RR    SRSRSR R     +    S +  + +  ++E+ R   RSRS  K R KK +
Sbjct: 264 SRHRR----SRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGR---RSRSTSKTRDKKKE 316

Query: 683 EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKK 742
           ++E+++ K   K     +  + +S++ R +R R   R+  +  S   K+ R  S +  KK
Sbjct: 317 DKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKK 376

Query: 743 STTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKS 802
              KD  K    D   RS+S+   S  ++K ++ K    + V++  R   +  + + S+ 
Sbjct: 377 EKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEK 436

Query: 803 RSR 805
             +
Sbjct: 437 EKK 439



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 39/145 (26%), Positives = 63/145 (43%), Gaps = 11/145 (7%)

Query: 196 QNRRERPSS-FRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKE 254
           + RR R +S  RD+++        + PP+  +  RR+  A  RE   +  R   +  +K 
Sbjct: 300 RGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSA-SRERRRRRSRSGTRSPKKP 358

Query: 255 RMEQQRSQLS------KKEKKATEDAEGG--DGPRLPQRSKFDSDEEEEDTENVEAASSG 306
           R  +++   S      KKEKK  +D E    +  R   + K   D+E++     E+    
Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDV 418

Query: 307 K-VTRSPSPVPQEEHSDPEMTEEEK 330
           K VTR      Q   S+ E  EE+K
Sbjct: 419 KQVTRDYDEEEQGYDSEKEKKEEKK 443



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 38/178 (21%), Positives = 66/178 (37%), Gaps = 18/178 (10%)

Query: 359 KDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHR 418
           +D  +K +K P K  + +    S           S +    RS  G+ S        R  
Sbjct: 316 EDKEKKRSKTPPKSYSTARRSRS----------ASRERRRRRSRSGTRSPKKPRSPKRKL 365

Query: 419 IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV 478
            R       +KEK++    DK  E  + + ER T +  +   KE++     E +      
Sbjct: 366 SRSPSPRRHKKEKKK----DKDKERSRDERERSTSKKKKSKDKEKDR----ERKSESDKD 417

Query: 479 VNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSY 536
           V +  R  +E     + +KE KE++K   + S  +   S    +  S   S V+   +
Sbjct: 418 VKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDH 475



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 21/79 (26%), Positives = 41/79 (51%), Gaps = 5/79 (6%)

Query: 727 ISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEK 786
           ++  ++    + D+     +++ K      S  S++  P   +EK+    +HSRSRS  +
Sbjct: 201 VAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKR----RHSRSRSRSR 256

Query: 787 SQRSGKKASRKHKSKSRSR 805
            +R+   +SR  +S+SRSR
Sbjct: 257 RRRT-PSSSRHRRSRSRSR 274



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 31/173 (17%), Positives = 57/173 (32%), Gaps = 8/173 (4%)

Query: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
           S   R       S    +  R R    +E   R     +    K+ ++EK++++   K  
Sbjct: 271 SRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSY 330

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
           +        S      R   G    +K R+P    S     + HK+++K+ + +  S   
Sbjct: 331 STARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDE 390

Query: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS--------SSPKRKKRHSR 560
              S++ +  S          S S    +  +R          S K KK   +
Sbjct: 391 RERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKK 443


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
           sapiens]
          Length = 434

 Score =  100 bits (248), Expect = 7e-21
 Identities = 72/227 (31%), Positives = 110/227 (48%), Gaps = 18/227 (7%)

Query: 501 EKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSR 560
           + E+ G +   +S            S S   S   YS S   SR   R S  + +K  SR
Sbjct: 5   DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSR 64

Query: 561 SRSPTIKARRSRSRSYSRRIKIESN---RARVKIRDRRRSNRNSIERERRRNRSPSRERR 617
           SRS   +   S+ +S  +    E N    +  K R+R  S+ N  +R +R+ R  SR R 
Sbjct: 65  SRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRS 124

Query: 618 RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDR 677
            SRSRSR+RR     RSRSR+R+K      + S +  + K  ++ +ERKK RSRS ++ R
Sbjct: 125 HSRSRSRERR----HRSRSRERKK------SRSRSRERKKSRSRSRERKKSRSRSRERKR 174

Query: 678 KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRS 724
           + + + R R + + + + +   +    S   DR K++ E  R FSRS
Sbjct: 175 RIRSRSRSRSRHRHRTRSRSRTR----SRSRDR-KKRIEKPRRFSRS 216



 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 59/183 (32%), Positives = 89/183 (48%), Gaps = 23/183 (12%)

Query: 496 KKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK 555
           K +++ ++ + RSRS       S   S     S   +   +SS  G  R +S  +   R 
Sbjct: 53  KSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRH 112

Query: 556 KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRE 615
           KR  R      K+ R RS S SR     S   R + R R R    S  RER+++RS SRE
Sbjct: 113 KRKER------KSSRGRSHSRSR-----SRERRHRSRSRERKKSRSRSRERKKSRSRSRE 161

Query: 616 RRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDK 675
           R++SRSRSR+R+    SRSRSR R +            H+ +  ++ + R ++R + I+K
Sbjct: 162 RKKSRSRSRERKRRIRSRSRSRSRHR------------HRTRSRSRTRSRSRDRKKRIEK 209

Query: 676 DRK 678
            R+
Sbjct: 210 PRR 212



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 79/268 (29%), Positives = 132/268 (49%), Gaps = 33/268 (12%)

Query: 442 EEEKQQTE-RVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHK 500
           +++K+Q+E  V+   ++  +    S S    R++D +    + R+ ++     E K +  
Sbjct: 21  DKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSS 80

Query: 501 EKEK--QGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRH 558
           +K K  +   +  SS  G    NS + +           SS G S + SRS     ++R 
Sbjct: 81  KKHKSEEHNDKEHSSDKGRERLNS-SENGEDRHKRKERKSSRGRSHSRSRS-----RERR 134

Query: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERR-RNRSPSRERR 617
            RSRS   K  RSRSR        E  ++R + R+R++S   S ER+RR R+RS SR R 
Sbjct: 135 HRSRSRERKKSRSRSR--------ERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRH 186

Query: 618 RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHK------HKGEAKEQERKKERSR 671
           R R+RSR R     +RSRSRDR+K  ++    S +  +       +G     + ++  +R
Sbjct: 187 RHRTRSRSR-----TRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALAR 241

Query: 672 SIDKDRKKKDKEREREQDKRKEKQKREE 699
            +++  KK  ++RE+E     EKQK++E
Sbjct: 242 RLER-AKKLQEQREKEM---VEKQKQQE 265



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 54/196 (27%), Positives = 94/196 (47%), Gaps = 18/196 (9%)

Query: 611 SPSRERRRSRSR-SRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKER 669
           SP R++++ +S  S   R ++   SRSR R +   ++ +  G  H+ +  +KE  R + +
Sbjct: 17  SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESK 76

Query: 670 SRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISV 729
            +S  K + ++  ++E   DK +E+    E       +  R +RK    R+ SRS S   
Sbjct: 77  DKSSKKHKSEEHNDKEHSSDKGRERLNSSENG---EDRHKRKERKSSRGRSHSRSRS--- 130

Query: 730 KIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR 789
           +  RH SR   +K +   S++   S S  R   +S   S+E+K +    SRSRS      
Sbjct: 131 RERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRS------ 184

Query: 790 SGKKASRKHKSKSRSR 805
                  +H+++SRSR
Sbjct: 185 -----RHRHRTRSRSR 195



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 23/264 (8%)

Query: 550 SSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRN 609
           +SP R K+  + +S    + R+    YSR        +R + R+R+R + N    E R++
Sbjct: 16  TSPDRDKK--KEQSEVSVSPRASKHHYSR--------SRSRSRERKRKSDN----EGRKH 61

Query: 610 RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKER 669
           RS SR +   R  S+D+ + +       D+    D+      +S   +   K +ERK  R
Sbjct: 62  RSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 121

Query: 670 SRSIDKDRKKKDKEREREQDKRKEKQK-REEKDFKFSSQDDRLKRKRESERTFS-RSGSI 727
            RS  + R ++ + R R ++++K + + RE K  +  S++ +  R R  ER    RS S 
Sbjct: 122 GRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSR 181

Query: 728 SVKIIRHDSRQDSK-KSTTKDSKK-----HSGSDSSGRSSSESPGSSKEKKAKKPKHSRS 781
           S    RH +R  S+ +S ++D KK        S S  R+ S  P   +   A   + + +
Sbjct: 182 SRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGR-NTAMDAQEALA 240

Query: 782 RSVEKSQRSGKKASRKHKSKSRSR 805
           R +E++++  ++  ++   K + +
Sbjct: 241 RRLERAKKLQEQREKEMVEKQKQQ 264



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 45/152 (29%), Positives = 68/152 (44%), Gaps = 14/152 (9%)

Query: 662 EQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTF 721
           E++       S D+D+KK+  E        K    R        S+    KRK ++E   
Sbjct: 7   ERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSR------SRSRERKRKSDNEGRK 60

Query: 722 SRSGSISVKIIRHDSRQDSK---KSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKP-- 776
            RS S S +  RH+S+  S    KS   + K+HS      R +S   G  + K+ ++   
Sbjct: 61  HRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSS 120

Query: 777 ---KHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
               HSRSRS E+  RS  +  +K +S+SR R
Sbjct: 121 RGRSHSRSRSRERRHRSRSRERKKSRSRSRER 152



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 41/203 (20%), Positives = 87/203 (42%), Gaps = 11/203 (5%)

Query: 400 RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEK-QQTERVT---KEM 455
           RS  G      D    +H+  +  +     +K ++ L+  +  E++ ++ ER +   +  
Sbjct: 66  RSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSH 125

Query: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
           +    +E+   S    R+       E+K++ + +    + +   +E++++ RSRS S S 
Sbjct: 126 SRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSR 185

Query: 516 GS--SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
               + S SRT S S              SR+ SR+ SP       R R+  + A+ + +
Sbjct: 186 HRHRTRSRSRTRSRSRD-RKKRIEKPRRFSRSLSRTPSPP----PFRGRNTAMDAQEALA 240

Query: 574 RSYSRRIKIESNRARVKIRDRRR 596
           R   R  K++  R +  +  +++
Sbjct: 241 RRLERAKKLQEQREKEMVEKQKQ 263


>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
           sapiens]
          Length = 1031

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 86/270 (31%), Positives = 123/270 (45%), Gaps = 34/270 (12%)

Query: 535 SYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDR 594
           S S     SR+ SRS S KR KR           RRSRSR   RR      R R + RD+
Sbjct: 12  SASRGRSGSRSRSRSPSDKRSKRGD--------DRRSRSRDRDRR------RERSRSRDK 57

Query: 595 RRS---NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSG 651
           RRS   +R  + R R R R  SRERRRSRSR R     R SRSRSR RR      GN   
Sbjct: 58  RRSRSRDRKRLRRSRSRERDRSRERRRSRSRDR-----RRSRSRSRGRRSRSSSPGN--- 109

Query: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711
            S K +  ++ +E+      S +K + K DKE E+E+D     Q + E++ +   + +R+
Sbjct: 110 KSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMR--KRKERV 167

Query: 712 KRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSS--- 768
           ++ RE +R  +      +K    + +Q  K S   D         + +  +E  G     
Sbjct: 168 EKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDP 227

Query: 769 ----KEKKAKKPKHSRSRSVEKSQRSGKKA 794
                E+  ++ K    RSV+    + KK+
Sbjct: 228 LDAYMEEVKEEVKKFNMRSVKGGGGNEKKS 257



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 77/277 (27%), Positives = 119/277 (42%), Gaps = 20/277 (7%)

Query: 496 KKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK 555
           +  H  K    R RSGS S   S S+ R+       S S         R   R  S  R 
Sbjct: 4   ESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSR-------DRDRRRERSRSRD 56

Query: 556 KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRE 615
           KR SRSR    + RRSRSR   R       R R + RDRRRS   S  R R R+ SP  +
Sbjct: 57  KRRSRSRDRK-RLRRSRSRERDR----SRERRRSRSRDRRRSRSRSRGR-RSRSSSPGNK 110

Query: 616 RRRSRSRSRDRRT---NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRS 672
            +++ +RSR +       +S+ + +D+   +D++   +GN  ++K E +E  ++KER   
Sbjct: 111 SKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLE-EEMRKRKERVEK 169

Query: 673 IDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKII 732
             ++++KK  E   E  K  E+ K+ +K +     DD      E+E+  +      +  +
Sbjct: 170 WREEQRKKAMENIGELKKEIEEMKQGKK-WSLEDDDDDEDDPAEAEKEGNEMEGEELDPL 228

Query: 733 RHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSK 769
             D+  +  K   K     S     G      P  +K
Sbjct: 229 --DAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTK 263



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 34/204 (16%)

Query: 603 ERERRRNRSPSRERRRSRSRSR---DRRTNRAS--RSRSRDRRKIDDQRGNLSGNSHKHK 657
           E    R RS SR R  SRSRSR   D+R+ R    RSRSRDR    D+R           
Sbjct: 4   ESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDR----DRR----------- 48

Query: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRES 717
              +E+ R +++ RS  +DRK+  + R RE+D+ +E+++   +D + S    R +R    
Sbjct: 49  ---RERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRR---- 101

Query: 718 ERTFSRSGSISVKIIRHDSRQDSKKST---TKDSKKHSGSDSSGRSSSESPGSSKEKKAK 774
               SRS S   K  + ++R  SK+ T       +K    D       +  G+  + K +
Sbjct: 102 ----SRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLE 157

Query: 775 KPKHSRSRSVEKSQRSGKKASRKH 798
           +    R   VEK +   +K + ++
Sbjct: 158 EEMRKRKERVEKWREEQRKKAMEN 181



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 59/198 (29%), Positives = 82/198 (41%), Gaps = 63/198 (31%)

Query: 604 RERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQ 663
           RE R  R  S  R RS SRSR       SRS S  R K  D R                 
Sbjct: 3   RESRHYRKRSASRGRSGSRSR-------SRSPSDKRSKRGDDR----------------- 38

Query: 664 ERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSR 723
                RSRS D+DR++   ER R +DKR+ + +  +          RL+R R  ER    
Sbjct: 39  -----RSRSRDRDRRR---ERSRSRDKRRSRSRDRK----------RLRRSRSRER---- 76

Query: 724 SGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRS 783
                      D  ++ ++S ++D ++        RS S SPG+  +K       +RSRS
Sbjct: 77  -----------DRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKK-----TENRSRS 120

Query: 784 VEKSQRSGKKASRKHKSK 801
            EK+   G+ +  K K K
Sbjct: 121 KEKTD-GGESSKEKKKDK 137



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 70/325 (21%), Positives = 120/325 (36%), Gaps = 63/325 (19%)

Query: 471 AREADGDVVNEKKRTPNETTSVLEPKKE--HKEKEKQGRSRSGSSSSGSSSSNSRTSSTS 528
           +R  D D   E+ R+ ++  S    +K        ++ RSR    S       SR     
Sbjct: 40  SRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSR----- 94

Query: 529 STVSSSSYSSSSGSSRTSSRSSSP--KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNR 586
                      S S    SRSSSP  K KK  +RSRS   K +     S   + K + ++
Sbjct: 95  -----------SRSRGRRSRSSSPGNKSKKTENRSRS---KEKTDGGESSKEKKKDKDDK 140

Query: 587 ARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQR 646
              K +D    ++N +E E R                  +R  R  + R   R+K  +  
Sbjct: 141 EDEKEKDAGNFDQNKLEEEMR------------------KRKERVEKWREEQRKKAMENI 182

Query: 647 GNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE-----------QDKRKEKQ 695
           G L       K E +E ++ K+ S   D D +    E E+E            D   E+ 
Sbjct: 183 GEL-------KKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEV 235

Query: 696 KREEKDFKFSSQDDRLKRKRESERTFSRSGSI---SVKIIRHDSRQDSKKSTTKDSKKHS 752
           K E K F   S       +++S  T ++  ++      ++  D ++       +D+ ++S
Sbjct: 236 KEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYS 295

Query: 753 GSDSSGRSSSESPG-SSKEKKAKKP 776
             +      +   G  +K++K  +P
Sbjct: 296 SEEEEVDLQTALTGYQTKQRKLLEP 320



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 37/143 (25%), Positives = 60/143 (41%), Gaps = 26/143 (18%)

Query: 663 QERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFS 722
           +E +  R RS  + R           DKR ++             DDR  R R+ +R   
Sbjct: 3   RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRG------------DDRRSRSRDRDRRRE 50

Query: 723 RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSR 782
           RS S           +D ++S ++D K+   S S  R  S     S+ +  ++   SRSR
Sbjct: 51  RSRS-----------RDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRR---SRSR 96

Query: 783 SVEKSQRSGKKASRKHKSKSRSR 805
           S  +  RS    ++  K+++RSR
Sbjct: 97  SRGRRSRSSSPGNKSKKTENRSR 119



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 62/331 (18%), Positives = 115/331 (34%), Gaps = 46/331 (13%)

Query: 393 SGDSEDERSDRG----SESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQT 448
           S    D+RS RG    S S D D    R R R K+ +  R    ++L   +  E ++ + 
Sbjct: 24  SRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRS--RSRDRKRLRRSRSRERDRSRE 81

Query: 449 ERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS 508
            R                     R    D    + R+    +    P   +K K+ + RS
Sbjct: 82  RR---------------------RSRSRDRRRSRSRSRGRRSRSSSP--GNKSKKTENRS 118

Query: 509 RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKA 568
           RS   + G  SS  +               +    +        KRK+R  + R    + 
Sbjct: 119 RSKEKTDGGESSKEKKKDKDDK-EDEKEKDAGNFDQNKLEEEMRKRKERVEKWR----EE 173

Query: 569 RRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSR-ERRRSRSRSRDRR 627
           +R ++      +K E       I + ++  + S+E +      P+  E+  +     +  
Sbjct: 174 QRKKAMENIGELKKE-------IEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELD 226

Query: 628 TNRASRSRSRDRRKIDDQRGNLSGNSHKHKG---EAKEQERKKERSRSIDKDRKKKDKER 684
              A     ++  K  + R    G  ++ K      K       +   +D D KKK +  
Sbjct: 227 PLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSD-KKKGELM 285

Query: 685 EREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715
           E +QD  +   + EE D + +    + K+++
Sbjct: 286 ENDQDAMEYSSEEEEVDLQTALTGYQTKQRK 316



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 32/148 (21%), Positives = 66/148 (44%), Gaps = 12/148 (8%)

Query: 189 PGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQ 248
           PG  +     R R     D   S  +   K++    +  K +    + +  LE+  R+++
Sbjct: 107 PGNKSKKTENRSRSKEKTDGGES--SKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRK 164

Query: 249 KKLEKERMEQQRSQLSK--KEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSG 306
           +++EK R EQ++  +    + KK  E+ + G      ++   + D+++ED +  EA   G
Sbjct: 165 ERVEKWREEQRKKAMENIGELKKEIEEMKQG------KKWSLEDDDDDED-DPAEAEKEG 217

Query: 307 KVTRSPSPVPQEEHSDPEMTEEEKEYQM 334
                    P + + + E+ EE K++ M
Sbjct: 218 NEMEGEELDPLDAYME-EVKEEVKKFNM 244


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 140/588 (23%), Positives = 236/588 (40%), Gaps = 91/588 (15%)

Query: 289 DSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLD 348
           + +  E+ ++N  +    K  +  S   + +HS  E  +++K+++     K    + ++D
Sbjct: 28  NGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEE--DKDKKHKHKHKHKKHKRKEIID 85

Query: 349 VTDEEIYYVAK-------------DAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGD 395
            +D+E    AK             +  R   KA          + S  GL  L GY SG 
Sbjct: 86  ASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLI-LQGYESGS 144

Query: 396 SED----ERSDRGSESSDTDD------EELRHRIRQKQEAFWRKEKEQQLLHDKQ----- 440
            E+    E++  G+ SS          E + ++I  K+ +  R ++  +   DK+     
Sbjct: 145 EEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGG 204

Query: 441 MEEEKQQTERV-TKEMNEFIHKEQNSLSLLEAREADGDVVNE-------KKRTPNETTSV 492
           +E  K++T R  +KE  +     + S S  +AR++    +         K R+P +    
Sbjct: 205 IEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVK 264

Query: 493 LEPKKEHKEKEK-----QGRSRS------------GSSSSGSSSSNSRTSSTSST----- 530
           +E K + K+++K     + RSR             G S    S S  R S  S T     
Sbjct: 265 IEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKK 324

Query: 531 -VSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV 589
            + S S  +SSG    S      +  KR S S  P  K+RRSRS   + R   +S     
Sbjct: 325 PIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSR 384

Query: 590 KIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKID----DQ 645
            +   RR+   S+ER+R   R P R RR S  R+R R    + R RS+D   I+     +
Sbjct: 385 TLSPGRRAKSRSLERKR---REPER-RRLSSPRTRPRDDILSRRERSKDASPINRWSPTR 440

Query: 646 RGNLSGNSHKHKGEAKEQERKKERSRS---IDKDRKKKDKEREREQDK--RKEKQKREEK 700
           R + S    + +   +     + RSRS    D+ R+ + + R R + +  R+ + + + K
Sbjct: 441 RRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVK 500

Query: 701 DFKF-------------SSQDDRLKR---KRESERTFSRSGSISVKIIRHDSRQDSKKST 744
           + KF             SS DD L+    + E E        I  + I    +  ++ S 
Sbjct: 501 EDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSN 560

Query: 745 TKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGK 792
                + S   SS R+ S SP    E+ A   K     +V+  + S K
Sbjct: 561 MSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVK 608



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 111/480 (23%), Positives = 207/480 (43%), Gaps = 83/480 (17%)

Query: 395 DSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKE 454
           D+  E+S        ++D+      R K++    + K ++  H  + +++K       K 
Sbjct: 17  DANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDK-------KH 69

Query: 455 MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEP--------KKEHKEKEKQG 506
            ++  HK+     +++A + +G  ++  KRT  +  ++LE         K E   +  +G
Sbjct: 70  KHKHKHKKHKRKEIIDASDKEG--MSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEG 127

Query: 507 RSRSG-----------SSSSGSSSSNSRTSSTSSTVSSSSYSSSS-GSSRTSSRSSSPKR 554
           + +SG           S   G     +R  + SST SSS+        ++ +++  S  R
Sbjct: 128 KVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSR 187

Query: 555 KKRHSRSRSPT---------IKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERE 605
            K  +R RS           +K + +RS+S  R+ K +S   R K +D+ R +++   R 
Sbjct: 188 SKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERK-KSKSPSKRSKSQDQARKSKSPTLRR 246

Query: 606 RRRN-----RSPSRERRR--SRSRSRDRRTNRA-SRSRSRDRRKIDDQRGNLSGNSHKHK 657
           R +      RSP+ ++ +   +S+S+DR+ +   + SRSRDR K      +L G S   +
Sbjct: 247 RSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRR 306

Query: 658 GEAKEQERKKE-------------RSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKF 704
             +KE++ K+              +  S  K+ +   +   R   +R    K  +K  + 
Sbjct: 307 SRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRS 366

Query: 705 SS---QDDRLKRKRESERTFS---RSGSISVKIIRHDS---RQDSKKSTTKD---SKKHS 752
            S    D R K+ +   RT S   R+ S S++  R +    R  S ++  +D   S++  
Sbjct: 367 RSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRER 426

Query: 753 GSDSSG-------RSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
             D+S        R  S SP     ++++ P   RSRS  +  RS ++  R  +S+SR R
Sbjct: 427 SKDASPINRWSPTRRRSRSP---IRRRSRSPLR-RSRSPRRRSRSPRRRDRGRRSRSRLR 482



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 70/351 (19%), Positives = 134/351 (38%), Gaps = 48/351 (13%)

Query: 187 GPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMERE 246
           G    P   + + E  S  +DR++SPI      E    D  K+   P  +R G  K  R 
Sbjct: 253 GKARSPTDDKVKIEDKSKSKDRKKSPII----NESRSRDRGKKSRSPVDLR-GKSKDRRS 307

Query: 247 KQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQR-----------SKFDSDEEEE 295
           + K+ + +R E  + +  K  K  ++DA  G   R P R           S    D+   
Sbjct: 308 RSKERKSKRSETDKEK--KPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRR 365

Query: 296 DTENVEAASSGKVTRSP----SPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTD 351
               +      K ++SP    SP  + +    E    E E + +   +    + +L   +
Sbjct: 366 SRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRE 425

Query: 352 EEIYYVAKDAH--------RKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDR 403
                 +KDA         R+ +++P ++ ++S    S +                R DR
Sbjct: 426 R-----SKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSP-------RRRSRSPRRRDR 473

Query: 404 GSESSDTDDEELRHR--IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHK 461
           G  S        R R   R++  +  +++K +  L +    E++  ++     + +F  +
Sbjct: 474 GRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSD---DNLEDFDVE 530

Query: 462 EQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGS 512
           E++  +L+E R      + +K +   E +++  P  E    +   R+RS S
Sbjct: 531 EEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVP-SEPSSPQSSTRTRSPS 580



 Score = 30.0 bits (66), Expect = 8.9
 Identities = 38/175 (21%), Positives = 68/175 (38%), Gaps = 33/175 (18%)

Query: 663 QERKKERSRSIDKDRKKKDKEREREQDKRKEKQKR--EEKDFKFSSQDDRLKRKRESER- 719
           ++   E+S + +     +D+ + +    +K+K K   + K  K SS++D+ K+ +   + 
Sbjct: 16  EDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKH 75

Query: 720 ----------TFSRSGSISVKIIRHD--------SRQDSKKSTTKDSKKHSGSDSSG--- 758
                        + G    K  + D         +Q +      D++   G   SG   
Sbjct: 76  KKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGL 135

Query: 759 -----RSSSESPGSSKEKKAKKPKHSRSRSVE---KSQRSGKKASRKHKSKSRSR 805
                 S SE  G   E KA+    S +RS     K +    K + K +SKSRS+
Sbjct: 136 ILQGYESGSEEEGEIHE-KARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK 189


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 100/480 (20%), Positives = 191/480 (39%), Gaps = 43/480 (8%)

Query: 351 DEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDT 410
           D++    A++  R+A +   +Q  +  +L  +T    +    S   E+ ++   +   + 
Sbjct: 31  DDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEG 90

Query: 411 DDEEL-------RHRIRQK--QEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHK 461
           DDE         R   RQK  QEA  R+++    + D  +    ++ +  T E NE   K
Sbjct: 91  DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE-NETTEK 149

Query: 462 EQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS-- 519
           E+ S S  E  E +      K    N+     E KKE KEKE++   +    S G +   
Sbjct: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209

Query: 520 ---SNSRTSSTSSTVSSSSYSSS-------------SGSSRTSSRSSSPKRKKRHSRSRS 563
                  T S   TV  S  +                GS   S      +  K  + +  
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAER 269

Query: 564 PTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRS 623
             ++A         +  KI   RAR++  ++  +     ERERR      R R   +  +
Sbjct: 270 ARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ----ERERREAEERERMREEEKRAA 325

Query: 624 RDR-RTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK 682
            +R R     +  + +R++I ++    +    + K E K    +++R+R+ +++ K K +
Sbjct: 326 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARA-EEEEKAKVE 384

Query: 683 EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKK 742
           E++R +   ++K   +E   K    + +++ K  +E+  ++   +   +++   +Q  +K
Sbjct: 385 EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK-AQEDKLQTAVLK---KQGEEK 440

Query: 743 STTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKS 802
            T   +K+    +       E     K KK K+PK        KS    KK   + KS++
Sbjct: 441 GTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE-----VKSFMDRKKGFTEVKSQN 495



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 81/426 (19%), Positives = 170/426 (39%), Gaps = 46/426 (10%)

Query: 411 DDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLE 470
           DD E R  +R+++    R E E+        +EE+   ER  +   E + ++Q   SL +
Sbjct: 2   DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61

Query: 471 ARE-----ADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTS 525
             +     A   V +E+ +T    T V E   E    E+  R R          +  R  
Sbjct: 62  VTDQVEVNAQNSVPDEEAKTTTTNTQV-EGDDEAAFLERLAR-REERRQKRLQEALERQK 119

Query: 526 STSSTVSSSSYS--SSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYS------ 577
               T++ +S S  S    + T+   ++ K +K  SR     I+   + ++SY       
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179

Query: 578 -------------------RRIKIESNRARVKIRDR-RRSNRNSIERERRRNRSPSRERR 617
                              +R  I  N+  V + ++   S   ++    +  +  S E +
Sbjct: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239

Query: 618 RSRSRSR-DRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKD 676
           +   R +     +   +    D+ + + +R  L     +     ++++   ER+R I+ +
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERAR-IEAE 298

Query: 677 RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDS 736
            K   +ERER + + +E+ + EEK     + ++R + K E +    R+     +I   + 
Sbjct: 299 EKAAAQERERREAEERERMREEEK----RAAEERQRIKEEEK----RAAEERQRIKEEEK 350

Query: 737 RQDSKKSTTKDSKKHSGSD-SSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKAS 795
           R   ++   K+ +K +  +    R+  E     +E+K  K    +  ++++++  G+K  
Sbjct: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410

Query: 796 RKHKSK 801
           +K + K
Sbjct: 411 QKIEGK 416



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 94/582 (16%), Positives = 226/582 (38%), Gaps = 80/582 (13%)

Query: 241 EKMEREKQKKLEKERMEQQRSQLS------KKEKKATEDAEGGDGPRLPQRSKFDSDEEE 294
           E+  RE++++  +ER+ Q++ + S      + E  A       +       ++ + D+E 
Sbjct: 35  EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEA 94

Query: 295 EDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEI 354
              E +      +  R    + +++  DP +T+                           
Sbjct: 95  AFLERLARREERRQKRLQEALERQKEFDPTITD--------------------------- 127

Query: 355 YYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEE 414
                     +   P++++   +A    T             ++E+S+   E  + ++ E
Sbjct: 128 ---------ASLSLPSRRMQNDTAENETT------------EKEEKSESRQERYEIEETE 166

Query: 415 LRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTER---VTKEMNEFIHKEQNSLSLLEA 471
              +  QK +  WR + E+    DK+ EEE+++  +   + +   E + +E+ + S  E 
Sbjct: 167 TVTKSYQKND--WR-DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223

Query: 472 ---READGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTS 528
                 +G + +E+ +   E     +    H++ E++ + R+ +  +   +         
Sbjct: 224 VVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE 283

Query: 529 STVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA- 587
                   +          ++++ +R++R +  R   ++    R+    +RIK E  RA 
Sbjct: 284 ---QDKKIADERARIEAEEKAAAQERERREAEERE-RMREEEKRAAEERQRIKEEEKRAA 339

Query: 588 --RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDR-RTNRASRSRSRDRRKIDD 644
             R +I++  +      +R +   +  + ER+R+R+   ++ +     R++  + +K   
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399

Query: 645 QRGNLSGNSHKHKGEAK-EQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFK 703
           Q   + G   + K E K   E+K +  +      KK+ +E+  +   ++EK + ++  FK
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459

Query: 704 FSS-QDDRLKRKRESERTFS-----RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSS 757
               +D+++K+ +E +         + G   VK    +      K T     +  G  S 
Sbjct: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHK 799
              + E+ G+ + +  K+ +  R R  E      +K  +K +
Sbjct: 520 --DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 559



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 95/516 (18%), Positives = 201/516 (38%), Gaps = 43/516 (8%)

Query: 244 EREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAA 303
           E E  +K EK    Q+R ++ + E   T+  +  D     +  K D ++EEE+ E  +  
Sbjct: 143 ENETTEKEEKSESRQERYEIEETET-VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 201

Query: 304 SSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
           S G+   +   V  EE +    TE ++E  +M L    ++       +E      + +H 
Sbjct: 202 SIGE---NQVEVMVEEKT----TESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHH 254

Query: 364 KATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQ 423
           +  +   K+ A++                  ++E+    +  +     DE  R    +K 
Sbjct: 255 EKMEEEDKERAEAERARL-------------EAEERERIKAEQDKKIADERARIEAEEKA 301

Query: 424 EAFWRKEKEQQLLHDKQMEEEKQQTE--RVTKEMNEFIHKEQNSLSLLEAREADGD--VV 479
            A  R+ +E +   ++  EEEK+  E  +  KE  +   +E+  +   E R A+    + 
Sbjct: 302 AAQERERREAEE-RERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360

Query: 480 NEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSS 539
            E+KR   E       + E +EK K    +          +   T      V        
Sbjct: 361 EEEKRAAEERQRA---RAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417

Query: 540 SGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR 599
               +           K+    +   ++A+R + +      K E  +     +D+     
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477

Query: 600 NSIERERRRN----RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDD----QRGNLSG 651
                +R++     +S + E    + +  +   +R     S D ++ +     + G    
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 537

Query: 652 NSHKHKGEAKEQE----RKKERSRSID-KDRKKKDKEREREQDKRKEKQKREEKDFKFSS 706
              + +GE + +E    ++K++  +++ ++ KKK +ER +  ++ ++++K+EE D K   
Sbjct: 538 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 597

Query: 707 QDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKK 742
           ++++ + K E ER  + +     K +  D   D KK
Sbjct: 598 EEEKRRLKEEIERRRAEAAEKRQK-MPEDGLSDDKK 632



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 70/409 (17%), Positives = 147/409 (35%), Gaps = 63/409 (15%)

Query: 237 REGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEED 296
           R  LE  ERE+ K  + +++  +R+++  +EK A ++ E         R + +  E   +
Sbjct: 269 RARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE---------RREAEERERMRE 319

Query: 297 TENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYY 356
            E   A    ++        +E      + EEEK                     EE   
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQ---RIKEEEKR------------------AAEERQR 358

Query: 357 VAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELR 416
           + K+  ++A +   +  A+    A +              E+++ ++  E      +E +
Sbjct: 359 I-KEEEKRAAEERQRARAEEEEKAKV--------------EEQKRNKQLEEKKHAMQETK 403

Query: 417 ---HRIRQKQEAFWRKEKEQQLLHDK-QMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAR 472
               ++ QK E  W  EK+ Q   DK Q    K+Q E    ++     K Q      +  
Sbjct: 404 IKGEKVEQKIEGKWVNEKKAQ--EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461

Query: 473 EADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS 532
           E   + + + K    E  S ++ KK   E     +S++G   +        T S     +
Sbjct: 462 EIKDEKIKKDKEPKEEVKSFMDRKKGFTEV----KSQNGEFMTHKLKHTENTFSRPGGRA 517

Query: 533 SSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR 592
           S     + G+ +  +     + ++R   + S   +  + + +  +  ++        +++
Sbjct: 518 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE--------ELK 569

Query: 593 DRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRK 641
            +R   R  +E E +R +    +R+      + R      R R+    K
Sbjct: 570 KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 618



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/228 (14%), Positives = 92/228 (40%), Gaps = 25/228 (10%)

Query: 602 IERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAK 661
           +ER  RR     +  + +  R ++        S S   R++ +          + K E++
Sbjct: 97  LERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156

Query: 662 EQERKKERSRSIDK-----------DRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDR 710
           ++  + E + ++ K           + KK+DKE+E E++++ ++    E   +   ++  
Sbjct: 157 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKT 216

Query: 711 LKRKRESERTFSRSGSISV--------------KIIRHDSRQDSKKSTTKDSKKHSGSDS 756
            + + E+     ++G IS               +I  H+  ++  K   +  +    ++ 
Sbjct: 217 TESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEE 276

Query: 757 SGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
             R  +E      +++A+     ++ + E+ +R  ++  R  + + R+
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRA 324



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 71/336 (21%), Positives = 133/336 (39%), Gaps = 64/336 (19%)

Query: 193 APPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLE 252
           A  Q R  R +  R+R R        +E  +    ++R     I+E  ++   E+Q+  E
Sbjct: 301 AAAQERERREAEERERMR--------EEEKRAAEERQR-----IKEEEKRAAEERQRIKE 347

Query: 253 KE-RMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRS 311
           +E R  ++R ++ ++EK+A E+          QR++     EEE+   VE     K    
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEER---------QRAR----AEEEEKAKVEEQKRNKQLEE 394

Query: 312 PSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAK 371
                QE     E  E++ E + +   K    ++   V       + K    K TK  AK
Sbjct: 395 KKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAV-------LKKQGEEKGTKVQAK 447

Query: 372 --QLAQSSALASLTGLGGLGGYGSGDSEDE------RSDRGSESSDTDDEELRHRIRQKQ 423
             +L +         +         + ++E      R    +E    + E + H+++  +
Sbjct: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507

Query: 424 EAFWR---------KEKE--QQLLHDKQMEE-EKQQTERVTKEMNEFIHKEQNSLSLLEA 471
             F R         KE E   Q+   K++EE  +++ E  ++E  +   K+Q +   LE 
Sbjct: 508 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE- 566

Query: 472 READGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGR 507
                    E K+   E   VLE +++ +++E+  R
Sbjct: 567 ---------ELKKKREERRKVLEEEEQRRKQEEADR 593



 Score = 36.6 bits (83), Expect = 0.095
 Identities = 62/361 (17%), Positives = 140/361 (38%), Gaps = 22/361 (6%)

Query: 198 RRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERME 257
           + E   +  +RQR      +K+E  +  A +R+ +    +   E+ +R + ++ EK ++E
Sbjct: 332 KEEEKRAAEERQR------IKEEEKRA-AEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384

Query: 258 QQRSQLSKKEKKATEDAEGGDGPRLPQR------SKFDSDEEEEDTENVEAASSGKVTRS 311
           +Q+     +EKK         G ++ Q+      ++  + E++  T  ++     K T+ 
Sbjct: 385 EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKV 444

Query: 312 PSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAK 371
            +   + +   P   +EE + + +   K    E+   +  ++ +   K  + +      K
Sbjct: 445 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 504

Query: 372 QLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWR-KE 430
               + +          GG  S D+++       E+    +E  R R   + E F + K+
Sbjct: 505 HTENTFSRP--------GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556

Query: 431 KEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETT 490
           K+Q+   + +  ++K++  R   E  E   K++ +   L   E    +  E +R   E  
Sbjct: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616

Query: 491 SVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSS 550
              +   E    + +   +  +    S     R    + +V  SS   S+  +   S+  
Sbjct: 617 EKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKID 676

Query: 551 S 551
           S
Sbjct: 677 S 677


>gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens]
          Length = 334

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 87/286 (30%), Positives = 134/286 (46%), Gaps = 18/286 (6%)

Query: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPK 553
           + ++E + K K+   R  SSSS   SS+SRT S       S   S S S     RS S  
Sbjct: 7   DTEEESRSKRKKKHRRRSSSSS---SSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYD 63

Query: 554 RKKRHSRSRSPTIKARRSRSRSYSRRI--KIESNRARVKIRDRRRSNRNSIERERRRNRS 611
           R++RH  S S +  +RR RSRS SR         R+R K R RR  +R  +    R +  
Sbjct: 64  RRRRHRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSER 123

Query: 612 PSRERRRSRSRSRDRRTNRASRSRSRDRRKIDD------QRGNLSGNSHKHKGEAKEQER 665
            S  R RSRSR R+RR  R    R +++ K  D      +RG  SGN           E+
Sbjct: 124 SSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGE-SGNIKAGLEHLPPAEQ 182

Query: 666 KKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSG 725
            K R + + +   K D+  + ++   +E ++R+E+D   ++  +++KR +E E     S 
Sbjct: 183 AKARLQLVLEAAAKADEALKAKERNEEEAKRRKEED--QATLVEQVKRVKEIEAI--ESD 238

Query: 726 SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK 771
           S   +  R  S ++ KKS      K + S S   S+   P S++++
Sbjct: 239 SFVQQTFR--SSKEVKKSVEPSEVKQATSTSGPASAVADPPSTEKE 282



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 70/224 (31%), Positives = 112/224 (50%), Gaps = 16/224 (7%)

Query: 542 SSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNS 601
           SS T   S S KRKK+H R  S    +  S SR+YSR+     +R++ +   R    R+ 
Sbjct: 5   SSDTEEESRS-KRKKKHRRRSS---SSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSH 60

Query: 602 IERERRRNRSPS-----RERRRSRSRSRDR-RTNRASRSRSRDRRKIDDQRGNLSGNSHK 655
               RRR+RS S       R+RSRSRSR R ++ R  RSRS+ R +    R  L      
Sbjct: 61  SYDRRRRHRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRL----RS 116

Query: 656 HKGEAKEQERKKERSRSIDKDRKK-KDKE-REREQDKRKEKQKREEKDFKFSSQDDRLKR 713
           H   ++    ++ RSRS D++R+K +DKE RE+E+DK K+K+    K  +  +    L+ 
Sbjct: 117 HSRSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGESGNIKAGLEH 176

Query: 714 KRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSS 757
              +E+  +R   +     + D    +K+   +++K+    D +
Sbjct: 177 LPPAEQAKARLQLVLEAAAKADEALKAKERNEEEAKRRKEEDQA 220



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 16/168 (9%)

Query: 639 RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKD-RKKKDKEREREQDKRKEKQKR 697
           RR  D +  + S    KH+  +        R+ S  K  RK + K R   +D +      
Sbjct: 3   RRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSY 62

Query: 698 EEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSS 757
           + +    SS       +R+  R+ SR    S ++ R  S+  +++S ++  +  S S SS
Sbjct: 63  DRRRRHRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRP-RLRSHSRSS 121

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
            RSS               + +RSRS ++ +R G+   ++ K K + +
Sbjct: 122 ERSSH--------------RRTRSRSRDRERRKGRDKEKREKEKDKGK 155



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 21/49 (42%), Positives = 27/49 (55%), Gaps = 2/49 (4%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR--SGKKASRKHKSKSRS 804
           GR SS++   S+ K+ KK +   S S     R  S KK  RK +SKSRS
Sbjct: 2   GRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRS 50



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 5/96 (5%)

Query: 406 ESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNS 465
           E++   DE L+ + R ++EA  RKE++Q  L    +E+ K+  E    E + F+ +   S
Sbjct: 192 EAAAKADEALKAKERNEEEAKRRKEEDQATL----VEQVKRVKEIEAIESDSFVQQTFRS 247

Query: 466 LSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKE 501
              ++ +  +   V +   T    ++V +P    KE
Sbjct: 248 SKEVK-KSVEPSEVKQATSTSGPASAVADPPSTEKE 282


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 122/614 (19%), Positives = 242/614 (39%), Gaps = 84/614 (13%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           + R E+    R+RQ       V QE  + +  KR T+     E L++ E ++Q++L++E 
Sbjct: 221 KGREEKQQQRRERQDR-----VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE- 274

Query: 256 MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPV 315
            E+Q  +L ++E +     E     RL +  +    +EEE  E  E     +  R     
Sbjct: 275 -EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ--- 330

Query: 316 PQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQ 375
            QEE  + ++  E++E +   L +                   ++  R+  +   +Q   
Sbjct: 331 -QEERREQQLRREQEERREQQLRR------------------EQEEERREQQLRREQ--- 368

Query: 376 SSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKE----K 431
                                E+ER ++        +++LR   + ++E   R+E    +
Sbjct: 369 ---------------------EEERREQQLRR----EQQLRREQQLRREQQLRREQQLRR 403

Query: 432 EQQLLHDKQMEEEKQ--QTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNET 489
           EQQL  ++Q+  E+Q  + +++ +E  E  H++++     E R          KR   E 
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR---------LKREQEER 454

Query: 490 TSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS 549
              L+ ++E  E+ +Q R +             R                    R   R 
Sbjct: 455 RDWLK-REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR---RE 510

Query: 550 SSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRN 609
              +R++R  R        +R RS    RR + E     +K  + +R     +E+ERR  
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR-----LEQERREQ 565

Query: 610 RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKER 669
           R   RE+   R +   R   R  +   R++ +  +QR          + E +EQ  K+E 
Sbjct: 566 RL-KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624

Query: 670 SRSIDKDR--KKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSI 727
                + +  K +++E  R+Q  R+E+Q+R E+  K   +++RL+++ + E    R    
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684

Query: 728 SVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS 787
             +  +  +R+  K    K   +      + +S   S    +E + ++ +    R   +S
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 788 QRSGKKASRKHKSK 801
           +   ++  R H+ +
Sbjct: 745 ELQWQEEERAHRQQ 758



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 126/627 (20%), Positives = 246/627 (39%), Gaps = 75/627 (11%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           Q   +R    RDRQ       +++EP Q    KR+     + EG E  + EKQ++LE+  
Sbjct: 115 QEEDQRRFEPRDRQ-------LEEEPGQRRRQKRQEQERELAEGEE--QSEKQERLEQRD 165

Query: 256 MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPV 315
            +++  +L ++ ++  E  E        Q  K    EE  D E +      ++ R     
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225

Query: 316 PQEEHSDPE----MTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAK 371
            Q++  + +      EEEKE++          E +L   +E++            + P +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKR--------ETVLRKEEEKLQ----------EEEPQR 267

Query: 372 QLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKE- 430
           Q         L  L         + ++ R +R  E           ++R+KQE   R++ 
Sbjct: 268 QRELQEEEEQLRKL---------ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 431 ---KEQQLLHDKQMEEEKQQTERVTKEMNEF-IHKEQNSLSLLEAREADGDVVNEKKRTP 486
              +EQQ   ++Q E  +QQ  R  +E  E  + +EQ      E RE       E++R  
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEE----ERREQQLRREQEEERRE 374

Query: 487 NETTSVLEPKKEHK-EKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT 545
            +     + ++E +  +E+Q R               +                    R 
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434

Query: 546 SSRSSSPKRK---KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSI 602
             +    +R+   KR    R   +K      R    R K +  R +    + RR     +
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ---EEERRERWLKL 491

Query: 603 ERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKE 662
           E E RR +   RE++  R +  +RR  R  R    +R +   QR        + + E +E
Sbjct: 492 EEEERREQQERREQQLRREQE-ERREQRLKRQEEEERLQ---QRLRSEQQLRREQEERRE 547

Query: 663 QERKKERSRSIDKDRK----KKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESE 718
           Q  K+E  + ++++R+    K+++E  R+Q  ++E+++R++          RLKR++E E
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ----------RLKREQE-E 596

Query: 719 RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKH 778
           R   R     V+ +  + R++ +    +  ++            E       ++ ++ + 
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656

Query: 779 SRSRSVEKSQRSGKKASRKHKSKSRSR 805
            R +  E+ +R  ++  R+H+ + R +
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQ 683



 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 108/572 (18%), Positives = 234/572 (40%), Gaps = 95/572 (16%)

Query: 238  EGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDT 297
            E L + EREK+++ E ER  +++ +L ++E++   +    +  RL +R +   +EEE   
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER--EKRRLQERERQYREEEELQQ 1058

Query: 298  ENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYV 357
            E  +     + TR    + ++   + E+ +EE++         LL E             
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQ---------LLRE------------- 1096

Query: 358  AKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRH 417
              +  ++  +   +Q  +   L                 ++E      E      +EL  
Sbjct: 1097 --EPEKRRRQERERQCREEEEL----------------QQEEEQLLREEREKRRRQELER 1138

Query: 418  RIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGD 477
            + R+++E    +++E+QLL ++  +  +Q+ ER  +E  E   +E+  L     RE    
Sbjct: 1139 QYREEEEV---QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL-----REEQEK 1190

Query: 478  VVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS 537
               E++R   E   +   K++ + +++  RS           +  R +          Y 
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV--------YC 1242

Query: 538  SSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRS 597
                + +      S  R ++  +     +  ++ R R   RR        R + RDR   
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR--------RWQQRDRHFP 1294

Query: 598  NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHK 657
                +ERE ++       +RR R    +++  R  R   R R++ D +           +
Sbjct: 1295 EEEQLEREEQK-----EAKRRDRKSQEEKQLLREEREEKRRRQETDRK---------FRE 1340

Query: 658  GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRK-----EKQKREEKDFKFSSQDDRLK 712
             E   QER+++  R  ++DRK +++E   ++  RK     ++ +R+E++ KF  ++ +L+
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400

Query: 713  -RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK 771
             ++RE +    R      +  R + +Q S++   +D K         R   E     +E+
Sbjct: 1401 CQEREQQLRQDRD-----RKFREEEQQLSRQE--RDRKFREEEQQVRRQERERKFLEEEQ 1453

Query: 772  KAKKPKHSRSRSVEK--SQRSGKKASRKHKSK 801
            + ++ +H + R  E+   +R  ++  R+ + +
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 116/642 (18%), Positives = 253/642 (39%), Gaps = 67/642 (10%)

Query: 198  RRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERME 257
            +RE+      R +      ++QE  +   +KR       R+ L K E +++++ ++ R E
Sbjct: 591  KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 258  QQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQ 317
            QQ  +  + +++  E+       RL QR K + +EE  + E  E        R  S +P+
Sbjct: 651  QQERREQRLKREEEEE-------RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703

Query: 318  EE--------------HSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
             +              +S P   E ++  Q     K    E  L   +EE       AHR
Sbjct: 704  WQWQLESEADARQSKVYSRPRKQEGQRRRQEQE-EKRRRRESELQWQEEE------RAHR 756

Query: 364  KATKAPAKQ---LAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTD------DEE 414
            +  +   ++       +   S  G   L        + ER  R  E    +      +EE
Sbjct: 757  QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816

Query: 415  LRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREA 474
               R RQ++E    +EKE Q L +++  + +++ +++ +E +     ++   S  + R+ 
Sbjct: 817  KEQRRRQRRE----REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872

Query: 475  DG--DVVNEKKRTPN--------------ETTSVLEPKKEHKEKEKQGRSRSGSSSSGSS 518
                 +  E+KR  +              E   + E ++E + +E++ R R         
Sbjct: 873  KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE 932

Query: 519  SSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR 578
                +                    R   +    ++K+       P  + R+ R + Y  
Sbjct: 933  EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992

Query: 579  RIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
              +++    ++   +R +  R   ER+ R+     +E  +     R++R  +    + R+
Sbjct: 993  EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE 1052

Query: 639  RRKIDDQRGNLSGNSH--KHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQK 696
              ++  +   L G     + + E + Q RK+E  +  ++   +++ E+ R Q++  E+Q 
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER--ERQC 1110

Query: 697  REEKDFKFSSQ----DDRLKRKR-ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
            REE++ +   +    ++R KR+R E ER +     +  +      R++ +K   ++ ++ 
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE-EEQLLREEPEKRRRQELERQ 1169

Query: 752  SGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKK 793
               +   +   E     +++K ++ +  + R  E+ QR  +K
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 120/645 (18%), Positives = 255/645 (39%), Gaps = 112/645 (17%)

Query: 241  EKMEREKQKKLEKERMEQQRSQLSKKEK---KATEDAEGGDGPRLPQRSKFDSDEEEEDT 297
            E+ E   ++K E+ER EQ+  +  ++ +   K  E+ E  +  R  Q+ K D +EE  + 
Sbjct: 428  EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487

Query: 298  ----ENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEE 353
                E  E     +         QEE  +  +  +E+E +   L + L +E  L    EE
Sbjct: 488  WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER---LQQRLRSEQQLRREQEE 544

Query: 354  IYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE 413
                     +   +   K+L Q      L              + E+ +R  +    ++E
Sbjct: 545  ------RREQLLKREEEKRLEQERREQRL--------------KREQEERRDQLLKREEE 584

Query: 414  ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEARE 473
              + R++++QE   R E+  +    +++E+E+++ +R+ +E  E    E+    LL++ E
Sbjct: 585  RRQQRLKREQEE--RLEQRLKREEVERLEQEERREQRLKREEPE----EERRQQLLKSEE 638

Query: 474  ADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSS------SGSSSSNSRTSST 527
             +     + +R   E       ++E +E+ +Q   R           +      +R    
Sbjct: 639  QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698

Query: 528  SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS--------RSYSRR 579
            S          S   +R S   S P++++   R +    K RR  S        R++ ++
Sbjct: 699  SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758

Query: 580  IKIESNR--------------------ARVKIRDRRRSNRNSIERERRRNR----SPSRE 615
             + E  R                    AR  +R++R     + ER++R  R       +E
Sbjct: 759  QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818

Query: 616  RRRSRSRSRDR------------RTNRAS--------------RSRSRDRRKIDDQRGNL 649
            +RR + R R++            R  RA               R RS+++R+    R  L
Sbjct: 819  QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 650  SGNSHKHKGEA-----------KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698
                 + +              KEQ+  +E    + ++ ++K + +E+E+  R+E+Q ++
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 699  EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSG 758
            E++     + ++ +R++E ER + +   +  K  +    +  K+   +  KK+   +   
Sbjct: 939  EEEQLLREEREK-RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997

Query: 759  RSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803
            +   +     +EK+ ++    + R  ++ Q+  ++  R+ + K R
Sbjct: 998  QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 108/583 (18%), Positives = 235/583 (40%), Gaps = 61/583 (10%)

Query: 194  PPQNRRERPSSFRDRQ-RSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKK-L 251
            P + +RER     +RQ R    LP ++E  Q    +RR          ++ EREK+ + L
Sbjct: 789  PLREQRERQLRAEERQQREQRFLPEEEEKEQ----RRR----------QRREREKELQFL 834

Query: 252  EKERMEQQRS---QLSKKEKKATEDAEG--GDGPRLPQRSKFDSDEEEEDTENVEAASSG 306
            E+E   Q+R    QL ++E    ED E       R  Q+ ++  +EE +   +   A   
Sbjct: 835  EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894

Query: 307  --KVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRK 364
              +  R    + QEE  + +  E EK  +     +    E  L   +E++    ++  R+
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQ-ERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 365  ATKAPA----KQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHR-- 418
              +       K+L Q                  G+  ++R  +  E    ++EEL+    
Sbjct: 954  QERERQYRKDKKLQQKEEQLL------------GEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 419  --IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADG 476
              +R+++E   R+E E+Q     ++++E++Q  R  +E      +E+      E ++ + 
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061

Query: 477  DVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSY 536
             ++ E++ T        + +KE + ++++ +               R       +     
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE- 1120

Query: 537  SSSSGSSRTSSRSSSPKRKKRHSRS----------RSPTIKARRSRSRSYSRRIKIESNR 586
                   R   R    +R+ R                P  + R+   R Y    +++   
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180

Query: 587  ARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQR 646
             ++ +R+ +   R   ER+ R      R++R+ R R  D+R++   +        + D +
Sbjct: 1181 EQL-LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239

Query: 647  GNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSS 706
                G  ++   + ++ + +  +S+   +    + +ER+REQ++R+ +Q+  ++ F    
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR--DRHF---P 1294

Query: 707  QDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
            ++++L+R+ + E       S   K +  + R++ ++    D K
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 101/539 (18%), Positives = 230/539 (42%), Gaps = 46/539 (8%)

Query: 196  QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
            Q R ++    RDR+        ++E  Q+   +R        + + + ERE++   E+++
Sbjct: 1402 QEREQQLRQDRDRK-------FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454

Query: 256  MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPV 315
            + Q+R +  ++E++  ++ E     R  +  KF  +E++   +  +     +  RS  P 
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP- 1513

Query: 316  PQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQ 375
                  + +  EEE++       +  L E       E      +D  RK  +   +QL Q
Sbjct: 1514 ------ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE--EQLRQ 1565

Query: 376  SSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQL 435
                  L+       +   + +  R ++  +  + D+++LR +  Q+Q    R+E++++ 
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFME-DEQQLRRQEGQQQ---LRQERDRKF 1621

Query: 436  LHDKQM--EEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
              D+Q+  E E+QQ  R  ++  +F+ +E      L  +E +  + +++ R   E   +L
Sbjct: 1622 REDEQLLQEREEQQLHRQERD-RKFLEEEPQ----LRRQEREQQLRHDRDRKFREEEQLL 1676

Query: 494  EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPK 553
            + + E ++  +Q R R             R                    +   R    +
Sbjct: 1677 Q-EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ------------EEQQLRRQELER 1723

Query: 554  RKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPS 613
            + +   + R  T + +  R   Y + ++ E  R   + +  RR  R+   RE  + R   
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ-E 1782

Query: 614  RERRRSRSRSRDRRTNRASRSRS-RDRRKIDDQR--GNLSGNSHKHKGEAKEQERKKERS 670
            RE ++ RS+  DR+     + R  R+ +++  Q+  G       + + E +EQ  ++ER 
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842

Query: 671  RSIDKDRK--KKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSI 727
            R    + +   ++K R  EQ+  +E++++  ++ +   +++ ++R+++ E+   + G I
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEI 1901



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 118/631 (18%), Positives = 247/631 (39%), Gaps = 82/631 (12%)

Query: 238  EGLEKMEREKQKKLEKERMEQQRSQLSKKEKKAT-EDAEGGDGPRLPQRSKFDSDEEEED 296
            E L + EREK+++ E ER  ++  ++ ++E++   E+ E      L ++ + + + ++E+
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180

Query: 297  TENVEAASSGKVTRSPSPVPQEEHSDPEMTEEE--KEYQMMLLTKMLLTEILLDVTDEEI 354
             + +      +         +EE    +  ++    E Q   L      E    V D ++
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240

Query: 355  YYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEE 414
            Y   ++ + +  +    QL    +   L  L  LG     D E ER           +EE
Sbjct: 1241 YCKGRE-NEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEE 1297

Query: 415  LRHRIRQKQ--EAFWRKEKEQQLLHDKQMEEEK-QQTERVTKEMNEFIHKEQNSLSLLEA 471
               R  QK+      + ++E+QLL +++ E+ + Q+T+R  +E  + + + +     L  
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP--LRR 1355

Query: 472  READGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTV 531
            +E D     E+ R   +    LE ++  + +E++ +               +        
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 532  SSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRS---PTIKARRSRSRSYSRRIKIESNRAR 588
                    S   R        ++ +R  R R       + R+ R R +    ++   R  
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475

Query: 589  VKI----RDR---------RRSNRNSIERERR-RNRSPSRE------------------- 615
             ++    RDR         RR  R+   RE+  R++ P R+                   
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535

Query: 616  -----RRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHK-----HKGEAKEQER 665
                 RR+ R + R +  +R  R   + R++ ++Q+ +      K      K   +EQER
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595

Query: 666  K----------KERSRSIDKDRKKKDKEREREQDKRKEKQ-KREEKDFKFSSQDDRLKRK 714
            K          +E  + + ++R +K +E E+   +R+E+Q  R+E+D KF  ++ +L+R+
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655

Query: 715  RESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAK 774
               ++            +RHD  +D K    +   +        R   +     +E++ +
Sbjct: 1656 EREQQ------------LRHD--RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701

Query: 775  KPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
            + +  R    E+ Q   ++  RK + + + R
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLR 1732



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 114/617 (18%), Positives = 248/617 (40%), Gaps = 65/617 (10%)

Query: 196  QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL-----EKMEREKQKK 250
            Q R+   S  RDRQ       +  E  + D  + R    W +        E++ERE+QK+
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR--RWQQRDRHFPEEEQLEREEQKE 1306

Query: 251  LEK-ERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEE---EEDTENVEAASSG 306
             ++ +R  Q+  QL ++E++     +  D        KF  +E+   E + + +      
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETD-------RKFREEEQLLQEREEQPLRRQERD 1359

Query: 307  KVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKAT 366
            +  R      QE+    +  EEE+  +     +  L E       E    + +D  RK  
Sbjct: 1360 RKFREEELRHQEQGR--KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF- 1416

Query: 367  KAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE--ELRHRIRQKQE 424
            +   +QL++               +   + +  R +R  +  + + +  + RHR  +++E
Sbjct: 1417 REEEQQLSRQERDRK---------FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 425  AFWRKEKEQQLLH---DKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNE 481
               ++ +EQQL     D++  EE+QQ  R  ++      +EQ     L ++E +   + E
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK---FREQE----LRSQEPERKFLEE 1520

Query: 482  KKRTPNETTS--VLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSS 539
            +++   +      L+ +++ + +E+  + R             R       +S       
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580

Query: 540  SGSSRTSSRSSSPKRK----KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRR 595
                    R    +RK    ++  R +    + R+ R R +    ++   R   ++  R+
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH-RQ 1639

Query: 596  RSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHK 655
              +R  +E E +  R   +ER +     RDR+     R   +  ++ ++Q+        K
Sbjct: 1640 ERDRKFLEEEPQLRR---QEREQQLRHDRDRKF----REEEQLLQEGEEQQLRRQERDRK 1692

Query: 656  HKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715
             + E ++Q R++ER R   ++ ++  + +E E+  R+E+Q R+E + +   + +R ++  
Sbjct: 1693 FR-EEEQQLRRQERERKFLQEEQQL-RRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750

Query: 716  ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKK 775
            E E+         ++      RQ+  +   ++ +     +     S ES    +E++  +
Sbjct: 1751 EEEQLRPEREEQQLR------RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804

Query: 776  PKHSRSRSVEKSQRSGK 792
             +    + +   QR GK
Sbjct: 1805 -QEREEQQLRPQQRDGK 1820



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 47/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 572 RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRA 631
           R     RR +    +   +   RRR  R   ERE       S ++ R   R R RR    
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173

Query: 632 SRSR----SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
            R R     R+ R+ ++++          +   +EQ R++E      K R++K ++R   
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233

Query: 688 QDK------RKEKQKRE----EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSR 737
           QD+       KE +KRE    +++ K   ++ + +R+ + E    R      K+ R + R
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR------KLERQELR 287

Query: 738 QDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
           ++ ++   +  +         +   E     +E++ ++ +  +     + Q   ++  R+
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347

Query: 798 HKSKSRSR 805
            +   R +
Sbjct: 348 EQQLRREQ 355



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 20/209 (9%)

Query: 595 RRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH 654
           R   + S+ ++RR+      E  + R   RDR+       R R +R+ + +R    G   
Sbjct: 102 RCDGKESLLQDRRQ------EEDQRRFEPRDRQLEEEPGQRRRQKRQ-EQERELAEGEEQ 154

Query: 655 KHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRK 714
             K E  EQ  ++ R   + + R++    +ERE+ + +E+Q +  K  +     D  + +
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEW---QEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 715 RESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAK 774
           R       R G       R + +Q  ++   +  ++    +   R   E+    +E+K +
Sbjct: 212 RRELLELRRKG-------REEKQQQRRERQDRVFQEEEEKEWRKR---ETVLRKEEEKLQ 261

Query: 775 KPKHSRSRSVEKSQRSGKKASRKHKSKSR 803
           + +  R R +++ +   +K  R+   + R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRER 290


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 93/288 (32%), Positives = 138/288 (47%), Gaps = 17/288 (5%)

Query: 462  EQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQG--RSRSGSSSSGSSS 519
            E+ S S  E ++ D ++  + K T  ++       K  KEK++    RSRS  S S    
Sbjct: 1777 ERASESSSEEKD-DYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHK 1835

Query: 520  SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRR 579
            S  RTS + S     S  S S  S+T SRS S +R++R SRSRS   K+R  RS S  +R
Sbjct: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRS-RRRRRSSRSRS---KSRGRRSVSKEKR 1891

Query: 580  IKIESNRARVKIRDRRRSN-RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
             +   +R++ + R R+RS+ R++ +  R R+R+PSR R RS + SR RR+    R RS  
Sbjct: 1892 KRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR-RSRSHTPSRRRRSRSVGRRRS-- 1948

Query: 639  RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698
               I   R + +  S + +  ++       RSR+    R+ +   R      R+ + +  
Sbjct: 1949 -FSISPSRRSRT-PSRRSRTPSRRSRTPSRRSRT--PSRRSRTPSRRSRTPSRRRRSRSV 2004

Query: 699  EKDFKFSSQDDRLKRKRES-ERTFSRSGSISVKIIRHDSRQDSKKSTT 745
             +   FS    RL+R R    R FSRS  I  K  R   R  S K  T
Sbjct: 2005 VRRRSFSISPVRLRRSRTPLRRRFSRS-PIRRKRSRSSERGRSPKRLT 2051



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 83/316 (26%), Positives = 134/316 (42%), Gaps = 31/316 (9%)

Query: 500  KEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSS---------RSS 550
            K+ E+    R+G      +S   R  S +S V SS    +S SS             + +
Sbjct: 1740 KDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDT 1799

Query: 551  SPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNR 610
              K KK  +R +    K R S  RS S+R K   +++R +  + R        R R+R+ 
Sbjct: 1800 HEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESR-------SRARKRSS 1852

Query: 611  SPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
                 R ++RSRSR RR  R+SRSRS+ R      R ++S    K   + + + R+++R 
Sbjct: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSR-----GRRSVSKEKRKRSPKHRSKSRERKRK 1907

Query: 671  RSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVK 730
            RS  +D +K  + R R   +R        +         R  R     R+FS S S   +
Sbjct: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRR---------RRSRSVGRRRSFSISPSRRSR 1958

Query: 731  IIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQ-R 789
                 SR  S++S T   +  + S  S   S  S   S+ ++++     RS S+   + R
Sbjct: 1959 TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLR 2018

Query: 790  SGKKASRKHKSKSRSR 805
              +   R+  S+S  R
Sbjct: 2019 RSRTPLRRRFSRSPIR 2034



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 90/306 (29%), Positives = 131/306 (42%), Gaps = 41/306 (13%)

Query: 472  READGDVVNEKKRTPNETTSVLEPKKEH----KEKEKQGRSRSGSSSSGSSSSNSRTSST 527
            R A   VV+      +E++S  E K ++    K K+   +S+   +         R SS 
Sbjct: 1765 RSAASPVVSSMPERASESSS--EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 528  SSTVSSSSYSSSSGSSRTS-SRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNR 586
             S    S  S      RTS SRS + KR  +    RS T    RSRSRS  RR    S+R
Sbjct: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQT----RSRSRSRRRR---RSSR 1875

Query: 587  ARVKIRDRRRSNRNSIERERR----RNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI 642
            +R K R RR     S+ +E+R    ++RS SRER+R RS SRD R    +RSR+  RR  
Sbjct: 1876 SRSKSRGRR-----SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRR-- 1928

Query: 643  DDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRK-----EKQKR 697
                      SH      + +   + RS SI   R+ +   R      R+      + + 
Sbjct: 1929 --------SRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980

Query: 698  EEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR-HDSRQDSKK--STTKDSKKHSGS 754
              +  +  S+  R   +R   R+  R  S S+  +R   SR   ++  S +   +K S S
Sbjct: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040

Query: 755  DSSGRS 760
               GRS
Sbjct: 2041 SERGRS 2046



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 86/294 (29%), Positives = 122/294 (41%), Gaps = 52/294 (17%)

Query: 443  EEKQQTERVTK--EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHK 500
            EEK   E   K  + +E   K +N     + ++ D  + +  KR+ +      E K   +
Sbjct: 1785 EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSS-----EHKSRKR 1839

Query: 501  EKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSR 560
              E + R+R  SS S S  S +R+ S S     SS S S    R S      KR  +H R
Sbjct: 1840 TSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKH-R 1898

Query: 561  SRSPTIKARRSRSRSYSRRIKIESN----RARVKIRDRRRSNRNSIERER-------RRN 609
            S+S   K +RS SR   + ++  S     R+R     RRR +R S+ R R       RR+
Sbjct: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSR-SVGRRRSFSISPSRRS 1957

Query: 610  RSPSRERR----RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQER 665
            R+PSR  R    RSR+ SR  RT  + RSR+  RR     R              + +  
Sbjct: 1958 RTPSRRSRTPSRRSRTPSRRSRTP-SRRSRTPSRRSRTPSR------------RRRSRSV 2004

Query: 666  KKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESER 719
             + RS SI   R ++ +   R                +FS    R KR R SER
Sbjct: 2005 VRRRSFSISPVRLRRSRTPLRR---------------RFSRSPIRRKRSRSSER 2043



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 69/256 (26%), Positives = 114/256 (44%), Gaps = 24/256 (9%)

Query: 397  EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
            +++  D+G E     D  LR R ++ + +  +  K       +  E   +  +R +K  +
Sbjct: 1805 KNKNRDKG-EKEKKRDSSLRSRSKRSKSSEHKSRK-------RTSESRSRARKRSSKSKS 1856

Query: 457  EFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSG 516
                    S S    R +     +  +R+ ++      PK   K +E++ +  S   +  
Sbjct: 1857 HRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRK 1916

Query: 517  SSSSNSRT---SSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKAR--RS 571
            +  + SRT    S S T S    S S G  R+ S S S + +    RSR+P+ ++R    
Sbjct: 1917 TVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSR 1976

Query: 572  RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERER--------RRNRSPSRERRRSRSRS 623
            RSR+ SRR +  S R+R     RRR +R+ + R          RR+R+P R RR SRS  
Sbjct: 1977 RSRTPSRRSRTPSRRSRTP--SRRRRSRSVVRRRSFSISPVRLRRSRTPLR-RRFSRSPI 2033

Query: 624  RDRRTNRASRSRSRDR 639
            R +R+  + R RS  R
Sbjct: 2034 RRKRSRSSERGRSPKR 2049



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 75/293 (25%), Positives = 117/293 (39%), Gaps = 47/293 (16%)

Query: 351  DEEIYYVAKDAHRKATKAP-----AKQLAQSSALASLTGLGGLGGYGSGDSEDE---RSD 402
            D EI+   KD H K+ K        K+  + S+L S +       + S     E   R+ 
Sbjct: 1789 DYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRAR 1848

Query: 403  RGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE 462
            + S  S +   + R R R ++    R+    +     +    K++ +R  K  ++   ++
Sbjct: 1849 KRSSKSKSHRSQTRSRSRSRRR---RRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERK 1905

Query: 463  QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKE----------KQGRSRSGS 512
            +   S  + R+     V  + RTP+  +    P +  + +              RSR+ S
Sbjct: 1906 RKRSSSRDNRKT----VRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961

Query: 513  SSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSR 572
              S + S  SRT S  S   S    + S  SRT SR           R RS ++  RRS 
Sbjct: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-----------RRRSRSVVRRRSF 2010

Query: 573  SRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
            S S      +   R+R  +  RRR +R+ I    RR RS S ER RS  R  D
Sbjct: 2011 SIS-----PVRLRRSRTPL--RRRFSRSPI----RRKRSRSSERGRSPKRLTD 2052



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 20/83 (24%), Positives = 43/83 (51%), Gaps = 4/83 (4%)

Query: 640 RKIDDQRGNLSGNSHKHKGEAKEQERKKE----RSRSIDKDRKKKDKEREREQDKRKEKQ 695
           +KI++    +     ++K + KE  RK      ++   D+   KK K+ ++ ++K+K+K+
Sbjct: 63  QKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKK 122

Query: 696 KREEKDFKFSSQDDRLKRKRESE 718
           K +EK +K   ++   K K   +
Sbjct: 123 KEKEKKYKRQPEESESKTKSHDD 145



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 6/119 (5%)

Query: 242 KMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTE-NV 300
           K  + K+KK +KE+ ++ + Q  + E K     +G          KFDS+      E   
Sbjct: 112 KKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPT 171

Query: 301 EAASSGKVTRSPS-----PVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEI 354
            A    +   SP+     PV   E S+P + E  K         ++ T ++ + +++ +
Sbjct: 172 RAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSV 230


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 93/288 (32%), Positives = 138/288 (47%), Gaps = 17/288 (5%)

Query: 462  EQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQG--RSRSGSSSSGSSS 519
            E+ S S  E ++ D ++  + K T  ++       K  KEK++    RSRS  S S    
Sbjct: 1777 ERASESSSEEKD-DYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHK 1835

Query: 520  SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRR 579
            S  RTS + S     S  S S  S+T SRS S +R++R SRSRS   K+R  RS S  +R
Sbjct: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRS-RRRRRSSRSRS---KSRGRRSVSKEKR 1891

Query: 580  IKIESNRARVKIRDRRRSN-RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
             +   +R++ + R R+RS+ R++ +  R R+R+PSR R RS + SR RR+    R RS  
Sbjct: 1892 KRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR-RSRSHTPSRRRRSRSVGRRRS-- 1948

Query: 639  RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698
               I   R + +  S + +  ++       RSR+    R+ +   R      R+ + +  
Sbjct: 1949 -FSISPSRRSRT-PSRRSRTPSRRSRTPSRRSRT--PSRRSRTPSRRSRTPSRRRRSRSV 2004

Query: 699  EKDFKFSSQDDRLKRKRES-ERTFSRSGSISVKIIRHDSRQDSKKSTT 745
             +   FS    RL+R R    R FSRS  I  K  R   R  S K  T
Sbjct: 2005 VRRRSFSISPVRLRRSRTPLRRRFSRS-PIRRKRSRSSERGRSPKRLT 2051



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 83/316 (26%), Positives = 134/316 (42%), Gaps = 31/316 (9%)

Query: 500  KEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSS---------RSS 550
            K+ E+    R+G      +S   R  S +S V SS    +S SS             + +
Sbjct: 1740 KDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDT 1799

Query: 551  SPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNR 610
              K KK  +R +    K R S  RS S+R K   +++R +  + R        R R+R+ 
Sbjct: 1800 HEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESR-------SRARKRSS 1852

Query: 611  SPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
                 R ++RSRSR RR  R+SRSRS+ R      R ++S    K   + + + R+++R 
Sbjct: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSR-----GRRSVSKEKRKRSPKHRSKSRERKRK 1907

Query: 671  RSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVK 730
            RS  +D +K  + R R   +R        +         R  R     R+FS S S   +
Sbjct: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRR---------RRSRSVGRRRSFSISPSRRSR 1958

Query: 731  IIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQ-R 789
                 SR  S++S T   +  + S  S   S  S   S+ ++++     RS S+   + R
Sbjct: 1959 TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLR 2018

Query: 790  SGKKASRKHKSKSRSR 805
              +   R+  S+S  R
Sbjct: 2019 RSRTPLRRRFSRSPIR 2034



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 90/306 (29%), Positives = 131/306 (42%), Gaps = 41/306 (13%)

Query: 472  READGDVVNEKKRTPNETTSVLEPKKEH----KEKEKQGRSRSGSSSSGSSSSNSRTSST 527
            R A   VV+      +E++S  E K ++    K K+   +S+   +         R SS 
Sbjct: 1765 RSAASPVVSSMPERASESSS--EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 528  SSTVSSSSYSSSSGSSRTS-SRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNR 586
             S    S  S      RTS SRS + KR  +    RS T    RSRSRS  RR    S+R
Sbjct: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQT----RSRSRSRRRR---RSSR 1875

Query: 587  ARVKIRDRRRSNRNSIERERR----RNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI 642
            +R K R RR     S+ +E+R    ++RS SRER+R RS SRD R    +RSR+  RR  
Sbjct: 1876 SRSKSRGRR-----SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRR-- 1928

Query: 643  DDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRK-----EKQKR 697
                      SH      + +   + RS SI   R+ +   R      R+      + + 
Sbjct: 1929 --------SRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980

Query: 698  EEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR-HDSRQDSKK--STTKDSKKHSGS 754
              +  +  S+  R   +R   R+  R  S S+  +R   SR   ++  S +   +K S S
Sbjct: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040

Query: 755  DSSGRS 760
               GRS
Sbjct: 2041 SERGRS 2046



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 86/294 (29%), Positives = 122/294 (41%), Gaps = 52/294 (17%)

Query: 443  EEKQQTERVTK--EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHK 500
            EEK   E   K  + +E   K +N     + ++ D  + +  KR+ +      E K   +
Sbjct: 1785 EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSS-----EHKSRKR 1839

Query: 501  EKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSR 560
              E + R+R  SS S S  S +R+ S S     SS S S    R S      KR  +H R
Sbjct: 1840 TSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKH-R 1898

Query: 561  SRSPTIKARRSRSRSYSRRIKIESN----RARVKIRDRRRSNRNSIERER-------RRN 609
            S+S   K +RS SR   + ++  S     R+R     RRR +R S+ R R       RR+
Sbjct: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSR-SVGRRRSFSISPSRRS 1957

Query: 610  RSPSRERR----RSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQER 665
            R+PSR  R    RSR+ SR  RT  + RSR+  RR     R              + +  
Sbjct: 1958 RTPSRRSRTPSRRSRTPSRRSRTP-SRRSRTPSRRSRTPSR------------RRRSRSV 2004

Query: 666  KKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESER 719
             + RS SI   R ++ +   R                +FS    R KR R SER
Sbjct: 2005 VRRRSFSISPVRLRRSRTPLRR---------------RFSRSPIRRKRSRSSER 2043



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 69/256 (26%), Positives = 114/256 (44%), Gaps = 24/256 (9%)

Query: 397  EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
            +++  D+G E     D  LR R ++ + +  +  K       +  E   +  +R +K  +
Sbjct: 1805 KNKNRDKG-EKEKKRDSSLRSRSKRSKSSEHKSRK-------RTSESRSRARKRSSKSKS 1856

Query: 457  EFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSG 516
                    S S    R +     +  +R+ ++      PK   K +E++ +  S   +  
Sbjct: 1857 HRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRK 1916

Query: 517  SSSSNSRT---SSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKAR--RS 571
            +  + SRT    S S T S    S S G  R+ S S S + +    RSR+P+ ++R    
Sbjct: 1917 TVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSR 1976

Query: 572  RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERER--------RRNRSPSRERRRSRSRS 623
            RSR+ SRR +  S R+R     RRR +R+ + R          RR+R+P R RR SRS  
Sbjct: 1977 RSRTPSRRSRTPSRRSRTP--SRRRRSRSVVRRRSFSISPVRLRRSRTPLR-RRFSRSPI 2033

Query: 624  RDRRTNRASRSRSRDR 639
            R +R+  + R RS  R
Sbjct: 2034 RRKRSRSSERGRSPKR 2049



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 75/293 (25%), Positives = 117/293 (39%), Gaps = 47/293 (16%)

Query: 351  DEEIYYVAKDAHRKATKAP-----AKQLAQSSALASLTGLGGLGGYGSGDSEDE---RSD 402
            D EI+   KD H K+ K        K+  + S+L S +       + S     E   R+ 
Sbjct: 1789 DYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRAR 1848

Query: 403  RGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE 462
            + S  S +   + R R R ++    R+    +     +    K++ +R  K  ++   ++
Sbjct: 1849 KRSSKSKSHRSQTRSRSRSRRR---RRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERK 1905

Query: 463  QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKE----------KQGRSRSGS 512
            +   S  + R+     V  + RTP+  +    P +  + +              RSR+ S
Sbjct: 1906 RKRSSSRDNRKT----VRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961

Query: 513  SSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSR 572
              S + S  SRT S  S   S    + S  SRT SR           R RS ++  RRS 
Sbjct: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-----------RRRSRSVVRRRSF 2010

Query: 573  SRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
            S S      +   R+R  +  RRR +R+ I    RR RS S ER RS  R  D
Sbjct: 2011 SIS-----PVRLRRSRTPL--RRRFSRSPI----RRKRSRSSERGRSPKRLTD 2052



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 20/83 (24%), Positives = 43/83 (51%), Gaps = 4/83 (4%)

Query: 640 RKIDDQRGNLSGNSHKHKGEAKEQERKKE----RSRSIDKDRKKKDKEREREQDKRKEKQ 695
           +KI++    +     ++K + KE  RK      ++   D+   KK K+ ++ ++K+K+K+
Sbjct: 63  QKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKK 122

Query: 696 KREEKDFKFSSQDDRLKRKRESE 718
           K +EK +K   ++   K K   +
Sbjct: 123 KEKEKKYKRQPEESESKTKSHDD 145



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 6/119 (5%)

Query: 242 KMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTE-NV 300
           K  + K+KK +KE+ ++ + Q  + E K     +G          KFDS+      E   
Sbjct: 112 KKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPT 171

Query: 301 EAASSGKVTRSPS-----PVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEI 354
            A    +   SP+     PV   E S+P + E  K         ++ T ++ + +++ +
Sbjct: 172 RAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSV 230


>gi|169218320 PREDICTED: similar to BCL2-associated transcription
           factor 1 isoform 2 [Homo sapiens]
          Length = 869

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 95/283 (33%), Positives = 129/283 (45%), Gaps = 32/283 (11%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR--RIKIE 583
           S S + SS S S S  SSR+ SRS S  RKKR+ RSRS T    RSR R YSR  R    
Sbjct: 4   SNSRSHSSRSKSRSQSSSRSRSRSHS--RKKRY-RSRSRTYSRSRSRDRMYSRDYRRDYR 60

Query: 584 SNRARVKIRDRRRSNRNSIER--------------ERRRNRSPSRERRRSRSRSRDRRTN 629
           +NRA  +    R   R   +                RR +RSP   R RSRSRS  RR+ 
Sbjct: 61  NNRAMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSP--RRGRSRSRSPKRRSV 118

Query: 630 RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
            + RSRSR RR     R   S +S      +K    K+  S+  +K  KK + E  +E+ 
Sbjct: 119 SSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQ--EKQTKKAEGE-PQEES 175

Query: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
             K K + E KD   + + D  +   E  ++ + SG I   +  +D+   S  S +  + 
Sbjct: 176 PLKSKSQEEPKD---TFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIAT 232

Query: 750 KHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS-QRSG 791
             S S     S S++P  S    AK      S S++ S +RSG
Sbjct: 233 PPSQSS----SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSG 271



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 88/398 (22%), Positives = 160/398 (40%), Gaps = 52/398 (13%)

Query: 390 GYGSGDSEDERSDRGSESSD------------TDDEELRHRIRQKQEAFWRKEKEQQLLH 437
           G  + ++ED R  R S  +D            T++E L+++ +   +     +  ++  +
Sbjct: 397 GDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKN 456

Query: 438 DKQMEE----EKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
           DK  E     E+  T   TK+ ++   K    +++ +  ++   V +EK +   + +  L
Sbjct: 457 DKHKETGYVVERPST---TKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPL 513

Query: 494 EPKKEHKEKE---KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT-SSRS 549
               + +EK    ++   R    +S S     +       +  S+  +S    R  +S  
Sbjct: 514 HKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTL 573

Query: 550 SSPKRKKRHSRSRSPTIK---ARRSRSRSYSRRI--------KIESNRARVKIRDRRRSN 598
               +K++  RS    IK   A +S S S+ + I        +     A + + +R  S 
Sbjct: 574 VHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSY 633

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKG 658
           + + E    R +SP   RR   S S  R+          D R   ++R     N    KG
Sbjct: 634 QKATEEHSTRQKSPEIHRRIDISPSTLRK----------DTRLAGEERVFKEENQ---KG 680

Query: 659 EAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE----KQKREEKDFK-FSSQDDRLKR 713
           + K +    +    ID  RK++ KER   +  R+     KQ++  KD+K + S  D  K 
Sbjct: 681 DKKLRCDSADLRHDIDHRRKERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKH 740

Query: 714 KRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
           KRE + + S S S S         ++SKK   ++ K H
Sbjct: 741 KREQDHSLSSSSSASPSSPSSREEKESKKEREEEFKTH 778



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 137/713 (19%), Positives = 261/713 (36%), Gaps = 116/713 (16%)

Query: 106 DQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDN--RHIFNQNNHNFGGPPDNFAVGPVNQ 163
           + P  P +P P+   PPS+ S+  D+   +  +  ++  +Q++H+    P+    G V  
Sbjct: 219 NSPRSPHSPSPI-ATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGN 277

Query: 164 FDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQ 223
              ++                        +P QN    P      +RSP      Q  P+
Sbjct: 278 GSSRY------------------------SPSQNS---PIHHIPSRRSPAKTIAPQNAPR 310

Query: 224 IDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLP 283
            ++   R   ++  +G ++   +  K L++   E+ R  L  +     ++A    G    
Sbjct: 311 DES---RGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE-- 365

Query: 284 QRSKFDSDEEEEDTENVEAAS---SGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLT-- 338
              K  ++ E ED E ++  S   SGK   + S     E  D E TE+ ++++  +L   
Sbjct: 366 ---KGRAEGEWEDQEALDYFSDKESGKQKFNDS-----EGDDTEETEDYRQFRKSVLADQ 417

Query: 339 -KMLLTEILLDVTDEEIYYVAK---------DAHRKATKAPAKQLAQSSALASLTGLGGL 388
            K   T    +  +E + Y +K         D  R+      K+        S T     
Sbjct: 418 GKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNDKHKETGYVVERPSTTK---- 473

Query: 389 GGYGSGDSEDERSDRGSESSDTDDEE----------------LRHRIRQKQEAFWRKEKE 432
                   ED+ S+R +   +T   E                L   +  ++++ +R+E  
Sbjct: 474 ---DKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESP 530

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            ++   K +  +  + E   K     +       SL + R     +V+  K+   E  S+
Sbjct: 531 LRI---KMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKE-QEFRSI 586

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSS-----SNSRTSSTSSTVSSSSYSSSSGSSRTSS 547
            +    H +  +  +S S S      S           S + T+S    S    +   S+
Sbjct: 587 FD----HIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSYQKATEEHST 642

Query: 548 RSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERR 607
           R  SP+  +R   S  P+   + +R     R  K E+ +   K+R      R+ I+  R+
Sbjct: 643 RQKSPEIHRRIDIS--PSTLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRRK 700

Query: 608 RNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKK 667
                  ER + R  S+  R +R SR + +  +   + +     + HK + +        
Sbjct: 701 -------ERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKHKRE-QDHSLSSSS 752

Query: 668 ERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQ------DDRLKRKRESERTF 721
             S S    R++K+ ++ERE++ +   + +E   F   S+      DDR     +    +
Sbjct: 753 SASPSSPSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFHDDR----DDGVDYW 808

Query: 722 SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSG--RSSSESPGSSKEKK 772
           ++ G       R   R + KKS +     H      G      E+  +++EKK
Sbjct: 809 AKRGRGRGTFQRGRGRFNFKKSGSSPKWNHDKYQGDGIVEDEEETMENNEEKK 861



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 52/207 (25%), Positives = 81/207 (39%), Gaps = 21/207 (10%)

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDR------RTNRASRSRSRDRRKIDDQRGNLSGN 652
           R++      R++S S+   RSRSRS  R      R+   SRSRSRDR    D R +   N
Sbjct: 3   RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNN 62

Query: 653 -------SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705
                   ++ +G    Q       R      +     R     +R   + R  K    S
Sbjct: 63  RAMRRPYGYRGRGRGYYQGGGGRYHRG---GYRPVWNRRHSRSPRRGRSRSRSPKRRSVS 119

Query: 706 SQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESP 765
           SQ  R + +R    + S   S S     +     SK+   + S++     + G    ESP
Sbjct: 120 SQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR---RGSQEKQTKKAEGEPQEESP 176

Query: 766 GSSKEKKAKKP--KHSRSRSVEKSQRS 790
             SK ++  K   +H  S S+++  +S
Sbjct: 177 LKSKSQEEPKDTFEHDPSESIDEFNKS 203



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 46/179 (25%), Positives = 73/179 (40%), Gaps = 28/179 (15%)

Query: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711
           NS  H   +K + +   RSRS    RKK+ + R R   + + + +   +D++   +++R 
Sbjct: 5   NSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNNRA 64

Query: 712 KRKRESER------------TFSRSGSISVKIIRHD-------SRQDS-KKSTTKDSKKH 751
            R+    R             + R G   V   RH        SR  S K+ +    +  
Sbjct: 65  MRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSR 124

Query: 752 SGSDSSGRSSSESPGSSKEKK----AKKPKHSRSRSVEKSQRSGKKASRKH---KSKSR 803
           S S  S R SS SP SS  +     +K P   R  S EK  +  +   ++    KSKS+
Sbjct: 125 SRSRRSYR-SSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQ 182



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 151/738 (20%), Positives = 259/738 (35%), Gaps = 137/738 (18%)

Query: 165 DYQHGAAFGPPQG--GFHPPYWQPGPP----GPPAPPQNRRERPSSFRDRQRSPIALPVK 218
           DY++  A   P G  G    Y+Q G      G   P  NRR   S  R R RS       
Sbjct: 58  DYRNNRAMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRS------- 110

Query: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKK---EKKATEDAE 275
           + P +     +R+     R    +  R  +    +      +S +SK+   ++K T+ AE
Sbjct: 111 RSPKRRSVSSQRSRSRSRRS--YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAE 168

Query: 276 GGDGPRLPQRSK--------FDSDEEEE-DTENVEAASSGKVTRSPSPV---PQEEHSDP 323
           G      P +SK        F+ D  E  D  N  +A+SG +    S     P+  HS  
Sbjct: 169 GEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPS 228

Query: 324 EMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDA---------------------- 361
            +     +        ML T      T  +  +  + +                      
Sbjct: 229 PIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNS 288

Query: 362 ---HRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSE------------DERS----- 401
              H  + ++PAK +A  +A    +          GD E            DE S     
Sbjct: 289 PIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLL 348

Query: 402 DRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEK------QQTERVTKEM 455
           DRG+ + D +  + +   + + E  W  ++      DK+  ++K        TE  T++ 
Sbjct: 349 DRGN-TRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEE-TEDY 406

Query: 456 NEFIH-----------------------KEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            +F                         K ++ +SL   RE+DG    EK     ET  V
Sbjct: 407 RQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDG-FREEKNDKHKETGYV 465

Query: 493 LE----PKKEHKEKEKQGRSRSGSSSSGSSSS-NSRTSSTSSTVSSSSYSSSSGSSRTSS 547
           +E     K +HKE++K     +    + S     S         S   + +     +++ 
Sbjct: 466 VERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTF 525

Query: 548 RSSSPKRKKR-HSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR--NSIER 604
           R  SP R K   S S  P +K + +           +SNR     +DR  ++   +S+++
Sbjct: 526 REESPLRIKMIASDSHRPEVKLKMAPVPLD------DSNRPASLTKDRLLASTLVHSVKK 579

Query: 605 ER--RRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKE 662
           E+  R      +  + S+S S     +  S       +        LS     ++   +E
Sbjct: 580 EQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSYQKATEE 639

Query: 663 QERKKE-----RSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQD-----DRLK 712
              +++     R   I     +KD     E+   KE+ ++ +K  +  S D     D  +
Sbjct: 640 HSTRQKSPEIHRRIDISPSTLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRR 699

Query: 713 RKRESERTFSRSGSISVKIIRHDSRQDSKKS--TTKDSKKHS-----GSDSSGRSSSESP 765
           ++R  ER  S+    S    + +      K   + KD  KH         SS  +S  SP
Sbjct: 700 KERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSLSSSSSASPSSP 759

Query: 766 GSSKEKKAKKPKHSRSRS 783
            S +EK++KK +    ++
Sbjct: 760 SSREEKESKKEREEEFKT 777



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 77/355 (21%), Positives = 129/355 (36%), Gaps = 57/355 (16%)

Query: 470 EAREADGDVVNEKKRTPNETTSVLEPKK--EHKEKEKQGRSRSGSSSSGSSSSNSRTSST 527
           + ++A+G+   E   +P ++ S  EPK   EH   E        S++SG           
Sbjct: 163 QTKKAEGEPQEE---SPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDN 219

Query: 528 SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA 587
           S     S    ++  S++SS S +P     HS   +P+   + S S  +S          
Sbjct: 220 SPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPS---QHSHSIQHSPE-------- 268

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI----D 643
               R    S  N   R      SP       RS ++      A R  SR R        
Sbjct: 269 ----RSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGG 324

Query: 644 DQRGNLSGNSHKH------------KGEAKEQERKKERSRSIDKDRKKKDKEREREQDKR 691
           DQ    +G   K             +G  +++E  KE+    +K R + + E +   D  
Sbjct: 325 DQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGS--EKGRAEGEWEDQEALDYF 382

Query: 692 KEKQKREEKDFKFSSQDDRLKRKRESERTFSRS-----GSISVKIIRHDSRQDSKKSTTK 746
            +K+  ++K F  S  DD    + E  R F +S     G         ++ ++  K  +K
Sbjct: 383 SDKESGKQK-FNDSEGDDT--EETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSK 439

Query: 747 DSKKHSGSDSSGRSSS-----------ESPGSSKEKKAKKPKHSRSRSVEKSQRS 790
            S K +      R              E P ++K+K  ++ K+S   +V+K  +S
Sbjct: 440 VSLKGNRESDGFREEKNDKHKETGYVVERPSTTKDKHKEEDKNSERITVKKETQS 494



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 97/464 (20%), Positives = 160/464 (34%), Gaps = 48/464 (10%)

Query: 244 EREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAA 303
           E E  K   K  ++  R     +E+K  +  E G     P  +K    EE++++E +   
Sbjct: 430 EEEGLKYKSKVSLKGNRESDGFREEKNDKHKETGYVVERPSTTKDKHKEEDKNSERITVK 489

Query: 304 SSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
              K T+SP  V  E+  D           +    K    E     +   I  +A D+HR
Sbjct: 490 ---KETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFRE----ESPLRIKMIASDSHR 542

Query: 364 KATK---APAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG--------SESSDTDD 412
              K   AP   L  S+  ASLT    L        + E+  R           S  T +
Sbjct: 543 PEVKLKMAPV-PLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSE 601

Query: 413 EELRHRI----RQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE---QNS 465
             ++H +      K++ F   +     L ++    +K   E  T++ +  IH+      S
Sbjct: 602 SFIQHIVSLVHHVKEQYF---KSAAMTLSERFTSYQKATEEHSTRQKSPEIHRRIDISPS 658

Query: 466 LSLLEAREADGDVVNEKKRTPNE-----TTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSS 520
               + R A  + V +++    +      ++ L    +H+ KE   RS+    S GS  S
Sbjct: 659 TLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRRKE---RSKERGDSKGSRES 715

Query: 521 NSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRI 580
                   +      Y S    S+        KR++ HS S S +       SR      
Sbjct: 716 RGSRKQEKTPKDYKEYKSYKDDSK-------HKREQDHSLSSSSSASPSSPSSREEKESK 768

Query: 581 KIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRR 640
           K      +     +  S    + R R        +R         R   R +  R R R 
Sbjct: 769 KEREEEFKTHHEMKEYSGFAGVSRPRGTFHD---DRDDGVDYWAKRGRGRGTFQRGRGRF 825

Query: 641 KIDDQRGNLSGNSHKHKGEA-KEQERKKERSRSIDKDRKKKDKE 683
                  +   N  K++G+   E E +   +    KDR K++KE
Sbjct: 826 NFKKSGSSPKWNHDKYQGDGIVEDEEETMENNEEKKDRCKEEKE 869



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 16/48 (33%), Positives = 27/48 (56%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GRS+S S  S  + +++    SRSRS  + +R   ++    +S+SR R
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDR 49


>gi|117938254 BCL2-associated transcription factor 1 isoform 3 [Homo
           sapiens]
          Length = 747

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 95/284 (33%), Positives = 129/284 (45%), Gaps = 32/284 (11%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHS-RSRSPTIKARRSRSRSYSR--RIKI 582
           S S + SS S S S  SSR+ SRS S  RKKR+S RSRS T    RSR R YSR  R   
Sbjct: 4   SNSRSHSSRSKSRSQSSSRSRSRSHS--RKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDY 61

Query: 583 ESNRARVKIRDRRRSNRNSIER--------------ERRRNRSPSRERRRSRSRSRDRRT 628
            +NR   +    R   R   +                RR +RSP   R RSRSRS  RR+
Sbjct: 62  RNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSP--RRGRSRSRSPKRRS 119

Query: 629 NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQ 688
             + RSRSR RR     R   S +S      +K    K+  S+  +K  KK + E  +E+
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQ--EKQTKKAEGE-PQEE 176

Query: 689 DKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDS 748
              K K + E KD   + + D  +   E  ++ + SG I   +  +D+   S  S +  +
Sbjct: 177 SPLKSKSQEEPKD---TFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIA 233

Query: 749 KKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS-QRSG 791
              S S     S S++P  S    AK      S S++ S +RSG
Sbjct: 234 TPPSQSS----SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSG 273



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 18/170 (10%)

Query: 587 ARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQR 646
           A + + +R  S + + E    R +SP   RR   S S  R+  R +     + R   ++ 
Sbjct: 451 AAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAG----EERVFKEEN 506

Query: 647 GNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE----KQKREEKDF 702
                     KG+ K +    +    ID+ RK++ KER   +  R+     KQ++  KD+
Sbjct: 507 ---------QKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDY 557

Query: 703 K-FSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
           K + S  D  K KRE + + S S S S         ++SKK   ++ K H
Sbjct: 558 KEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTH 607



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 115/578 (19%), Positives = 209/578 (36%), Gaps = 86/578 (14%)

Query: 165 DYQHGAAFGPPQG--GFHPPYWQPGPP----GPPAPPQNRRERPSSFRDRQRSPIALPVK 218
           DY++      P G  G    Y+Q G      G   P  NRR   S  R R RS       
Sbjct: 60  DYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRS------- 112

Query: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKK---EKKATEDAE 275
           + P +     +R+     R    +  R  +    +      +S +SK+   ++K T+ AE
Sbjct: 113 RSPKRRSVSSQRSRSRSRRS--YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAE 170

Query: 276 GGDGPRLPQRSK--------FDSDEEEE-DTENVEAASSGKVTRSPSPV---PQEEHSDP 323
           G      P +SK        F+ D  E  D  N  +A+SG +    S     P+  HS  
Sbjct: 171 GEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPS 230

Query: 324 EMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDA---------------------- 361
            +     +        ML T      T  +  +  + +                      
Sbjct: 231 PIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNS 290

Query: 362 ---HRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHR 418
              H  + ++PAK +A  +A    +          GD E  ++ +  +S       L   
Sbjct: 291 PIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKSPP-----LHKN 345

Query: 419 IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV 478
           +  ++++ +R+E   ++   K +  +  + E   K     +       SL + R     +
Sbjct: 346 LDAREKSTFREESPLRI---KMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTL 402

Query: 479 VNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS-----SNSRTSSTSSTVSS 533
           V+  K+   E  S+ +    H +  +  +S S S      S           S + T++ 
Sbjct: 403 VHSVKKE-QEFRSIFD----HIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNE 457

Query: 534 SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR- 592
              S    +   S+R  SP+  +R   S  P+   + +R     R  K E+ +   K+R 
Sbjct: 458 RFTSYQKATEEHSTRQKSPEIHRRIDIS--PSTLRKHTRLAGEERVFKEENQKGDKKLRC 515

Query: 593 ---------DRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKID 643
                    DRRR  R+    + + +R  S  R++ ++  +D +  ++ +  S+ +R+ D
Sbjct: 516 DSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKT-PKDYKEYKSYKDDSKHKREQD 574

Query: 644 DQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKD 681
             R + S  S       +E+E KKER        + K+
Sbjct: 575 HSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKE 612



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 38/168 (22%), Positives = 74/168 (44%), Gaps = 15/168 (8%)

Query: 647 GNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSS 706
           G  +  SH  + +++ Q   + RSRS  + ++   + R R   + + + +   +D++   
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDY 61

Query: 707 QDDRLKRKRESER------------TFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGS 754
           +++R  R+    R             + R G   V   RH       +S ++  K+   S
Sbjct: 62  RNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRR--S 119

Query: 755 DSSGRSSSESPGSSKEKKAKKPKHSRSRS-VEKSQRSGKKASRKHKSK 801
            SS RS S S  S +  ++ +   SRS S   KS  S ++ S++ ++K
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTK 167



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 52/209 (24%), Positives = 81/209 (38%), Gaps = 23/209 (11%)

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDR--------RTNRASRSRSRDRRKIDDQRGNLS 650
           R++      R++S S+   RSRSRS  R        R+   SRSRSRDR    D R +  
Sbjct: 3   RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYR 62

Query: 651 GN-------SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFK 703
            N        ++ +G    Q       R      +     R     +R   + R  K   
Sbjct: 63  NNRGMRRPYGYRGRGRGYYQGGGGRYHRG---GYRPVWNRRHSRSPRRGRSRSRSPKRRS 119

Query: 704 FSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSE 763
            SSQ  R + +R    + S   S S     +     SK+   + S++     + G    E
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR---RGSQEKQTKKAEGEPQEE 176

Query: 764 SPGSSKEKKAKKP--KHSRSRSVEKSQRS 790
           SP  SK ++  K   +H  S S+++  +S
Sbjct: 177 SPLKSKSQEEPKDTFEHDPSESIDEFNKS 205



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 53/226 (23%), Positives = 85/226 (37%), Gaps = 19/226 (8%)

Query: 471 AREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSST 530
           +RE+ G    EK  TP +       K + K K +Q  SRS SSS+  SS +SR    S  
Sbjct: 541 SRESSGSRKQEK--TPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKK 598

Query: 531 VSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVK 590
                + +       S  +         SR R       R R R  +R +   +N     
Sbjct: 599 EREEEFKTHHEMKEYSGFAGV-------SRPRGTFF---RIRGRGRARGVFAGTNTG--- 645

Query: 591 IRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLS 650
                 SN    +R +     P    +  +    D R +       R R +   QRG   
Sbjct: 646 ---PNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGR 702

Query: 651 GNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQK 696
            N  K  G + +    K +   I +D ++  +  E ++D+RKE+++
Sbjct: 703 FN-FKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE 747



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 18/154 (11%)

Query: 631 ASRSRSRD-RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
           ++R +S +  R+ID     L     KH   A E+   KE ++  DK  +    +   + D
Sbjct: 470 STRQKSPEIHRRIDISPSTL----RKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDID 525

Query: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
           +R++++ +E  D K S +    +++ ++ + +    S          + DSK    +D  
Sbjct: 526 RRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSY---------KDDSKHKREQD-- 574

Query: 750 KHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRS 783
            HS S SS  S S SP S +EK++KK +    ++
Sbjct: 575 -HSRSSSSSASPS-SPSSREEKESKKEREEEFKT 606



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 103/473 (21%), Positives = 160/473 (33%), Gaps = 63/473 (13%)

Query: 391 YGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKE-KEQQLLHDKQMEEEKQQTE 449
           Y S  S    S R S          R   ++KQ      E +E+  L  K  EE K   E
Sbjct: 133 YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFE 192

Query: 450 RVTKE-MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS 508
               E ++EF      S  +     A     +   R+P+  + +  P  +          
Sbjct: 193 HDPSESIDEFNKSSATSGDIWPGLSA----YDNSPRSPHSPSPIATPPSQSSSCSDAPML 248

Query: 509 RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-- 566
            +  S+  + S +S  S   S   S S S  +GSSR S   +SP       RS + TI  
Sbjct: 249 STVHSAKNTPSQHSH-SIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAP 307

Query: 567 -KARRSRSRSYSRRIKIESNRARVKIRDRRRS-----NRNSIERERRRNRSPSR------ 614
             A R  SR  S       ++   K     +S     N ++ E+   R  SP R      
Sbjct: 308 QNAPRDESRGRSSFYPDGGDQETAKTGKFLKSPPLHKNLDAREKSTFREESPLRIKMIAS 367

Query: 615 -----------------ERRRSRSRSRDR---RTNRASRSRSRDRRKIDD-----QRGNL 649
                            +  R  S ++DR    T   S  + ++ R I D     Q    
Sbjct: 368 DSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKS 427

Query: 650 SGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDD 709
           +  S      +     K++  +S      ++    ++  ++   +QK  E   +      
Sbjct: 428 TSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPS 487

Query: 710 RLKRKRE---SERTFSRSGSISVKIIR-------HDSRQDSK-KSTTKDSKKHSGSDSSG 758
            L++       ER F        K +R       HD  +  K +S  +   K S   S  
Sbjct: 488 TLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGS 547

Query: 759 RSSSESPGSSKEKKAKK--PKHSR----SRSVEKSQRSGKKASRKHKSKSRSR 805
           R   ++P   KE K+ K   KH R    SRS   S      +SR+ K   + R
Sbjct: 548 RKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKER 600



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 17/48 (35%), Positives = 28/48 (58%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GRS+S S  S  + +++    SRSRS  + +R   ++  +  S+SRSR
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSR 49



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 747 DSKKHSG-SDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
           +S+ HS  S S  +SSS S   S  +K +    SRSR+  +S+   +  SR ++   R+
Sbjct: 5   NSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRN 63


>gi|7661958 BCL2-associated transcription factor 1 isoform 1 [Homo
           sapiens]
          Length = 920

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 95/284 (33%), Positives = 129/284 (45%), Gaps = 32/284 (11%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHS-RSRSPTIKARRSRSRSYSR--RIKI 582
           S S + SS S S S  SSR+ SRS S  RKKR+S RSRS T    RSR R YSR  R   
Sbjct: 4   SNSRSHSSRSKSRSQSSSRSRSRSHS--RKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDY 61

Query: 583 ESNRARVKIRDRRRSNRNSIER--------------ERRRNRSPSRERRRSRSRSRDRRT 628
            +NR   +    R   R   +                RR +RSP   R RSRSRS  RR+
Sbjct: 62  RNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSP--RRGRSRSRSPKRRS 119

Query: 629 NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQ 688
             + RSRSR RR     R   S +S      +K    K+  S+  +K  KK + E  +E+
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQ--EKQTKKAEGE-PQEE 176

Query: 689 DKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDS 748
              K K + E KD   + + D  +   E  ++ + SG I   +  +D+   S  S +  +
Sbjct: 177 SPLKSKSQEEPKD---TFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIA 233

Query: 749 KKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS-QRSG 791
              S S     S S++P  S    AK      S S++ S +RSG
Sbjct: 234 TPPSQSS----SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSG 273



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 87/399 (21%), Positives = 161/399 (40%), Gaps = 54/399 (13%)

Query: 390 GYGSGDSEDERSDRGSESSD------------TDDEELRHRIR-----QKQEAFWRKEKE 432
           G  + ++ED R  R S  +D            T++E L+++ +      ++   +R+EK 
Sbjct: 399 GDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKN 458

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            +L     + E    T+   KE +    K    +++ +  ++   V +EK +   + +  
Sbjct: 459 YKLKETGYVVERPSTTKDKHKEED----KNSERITVKKETQSPEQVKSEKLKDLFDYSPP 514

Query: 493 LEPKKEHKEKE---KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT-SSR 548
           L    + +EK    ++   R    +S S     +       +  S+  +S    R  +S 
Sbjct: 515 LHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLAST 574

Query: 549 SSSPKRKKRHSRSRSPTIK---ARRSRSRSYSRRI--------KIESNRARVKIRDRRRS 597
                +K++  RS    IK   A +S S S+ + I        +     A + + +R  S
Sbjct: 575 LVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTS 634

Query: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHK 657
            + + E    R +SP   RR   S S  R+  R +     + R   ++           K
Sbjct: 635 YQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAG----EERVFKEEN---------QK 681

Query: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE----KQKREEKDFK-FSSQDDRLK 712
           G+ K +    +    ID+ RK++ KER   +  R+     KQ++  KD+K + S  D  K
Sbjct: 682 GDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSK 741

Query: 713 RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
            KRE + + S S S S         ++SKK   ++ K H
Sbjct: 742 HKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTH 780



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 120/624 (19%), Positives = 231/624 (37%), Gaps = 107/624 (17%)

Query: 106 DQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDN--RHIFNQNNHNFGGPPDNFAVGPVNQ 163
           + P  P +P P+   PPS+ S+  D+   +  +  ++  +Q++H+    P+    G V  
Sbjct: 221 NSPRSPHSPSPI-ATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGN 279

Query: 164 FDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQ 223
              ++                        +P QN    P      +RSP      Q  P+
Sbjct: 280 GSSRY------------------------SPSQNS---PIHHIPSRRSPAKTIAPQNAPR 312

Query: 224 IDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLP 283
            ++   R   ++  +G ++   +  K L++   E+ R  L  +     ++A    G    
Sbjct: 313 DES---RGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE-- 367

Query: 284 QRSKFDSDEEEEDTENVEAAS---SGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLT-- 338
              K  ++ E ED E ++  S   SGK   + S     E  D E TE+ ++++  +L   
Sbjct: 368 ---KGRAEGEWEDQEALDYFSDKESGKQKFNDS-----EGDDTEETEDYRQFRKSVLADQ 419

Query: 339 -KMLLTEILLDVTDEEIYYVAK---------DAHRKATKAPAKQLAQSSALASLTGLGGL 388
            K   T    +  +E + Y +K         D  R+      K+        S T     
Sbjct: 420 GKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTK---- 475

Query: 389 GGYGSGDSEDERSDRGSESSDTDDEE----------------LRHRIRQKQEAFWRKEKE 432
                   ED+ S+R +   +T   E                L   +  ++++ +R+E  
Sbjct: 476 ---DKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESP 532

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            ++   K +  +  + E   K     +       SL + R     +V+  K+   E  S+
Sbjct: 533 LRI---KMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKE-QEFRSI 588

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSS-----SNSRTSSTSSTVSSSSYSSSSGSSRTSS 547
            +    H +  +  +S S S      S           S + T++    S    +   S+
Sbjct: 589 FD----HIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHST 644

Query: 548 RSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR----------DRRRS 597
           R  SP+  +R   S  P+   + +R     R  K E+ +   K+R          DRRR 
Sbjct: 645 RQKSPEIHRRIDIS--PSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRK 702

Query: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHK 657
            R+    + + +R  S  R++ ++  +D +  ++ +  S+ +R+ D  R + S  S    
Sbjct: 703 ERSKERGDSKGSRESSGSRKQEKT-PKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSP 761

Query: 658 GEAKEQERKKERSRSIDKDRKKKD 681
              +E+E KKER        + K+
Sbjct: 762 SSREEKESKKEREEEFKTHHEMKE 785



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 38/168 (22%), Positives = 74/168 (44%), Gaps = 15/168 (8%)

Query: 647 GNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSS 706
           G  +  SH  + +++ Q   + RSRS  + ++   + R R   + + + +   +D++   
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDY 61

Query: 707 QDDRLKRKRESER------------TFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGS 754
           +++R  R+    R             + R G   V   RH       +S ++  K+   S
Sbjct: 62  RNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRR--S 119

Query: 755 DSSGRSSSESPGSSKEKKAKKPKHSRSRS-VEKSQRSGKKASRKHKSK 801
            SS RS S S  S +  ++ +   SRS S   KS  S ++ S++ ++K
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTK 167



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 105/507 (20%), Positives = 178/507 (35%), Gaps = 67/507 (13%)

Query: 244 EREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAA 303
           E E  K   K  ++  R     +E+K  +  E G     P  +K   D+ +E+ +N E  
Sbjct: 432 EEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTK---DKHKEEDKNSERI 488

Query: 304 SSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
           +  K T+SP  V  E+  D           +    K    E     +   I  +A D+HR
Sbjct: 489 TVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFRE----ESPLRIKMIASDSHR 544

Query: 364 KATK---APAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG--------SESSDTDD 412
              K   AP   L  S+  ASLT    L        + E+  R           S  T +
Sbjct: 545 PEVKLKMAPVP-LDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSE 603

Query: 413 EELRHRI----RQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHK------- 461
             ++H +      K++ F   +     L+++    +K   E  T++ +  IH+       
Sbjct: 604 SFIQHIVSLVHHVKEQYF---KSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPS 660

Query: 462 ---EQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSS 518
              +   L+  E    + +   +KK   +      +  +  KE+ K+     GS  S  S
Sbjct: 661 TLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGS 720

Query: 519 SSNSRTSSTSSTVSS----SSYSSSSGSSRTSSRSSSP-----KRKKRHSRSRSPTIKAR 569
               +T        S    S +      SR+SS S+SP     + +K   + R    K  
Sbjct: 721 RKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTH 780

Query: 570 RSRSRSYSRRIKIESNRA---RVKIRDRRR------------SNRNSIERERRRNRSPSR 614
               + YS    +   R    R++ R R R            SN    +R +     P  
Sbjct: 781 HEM-KEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEY 839

Query: 615 ERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID 674
             +  +    D R +       R R +   QRG    N  K     K    K +    ++
Sbjct: 840 TPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVE 899

Query: 675 KDRKKKDKEREREQDKRKEKQKREEKD 701
                 D+E   E ++ K+ +++EEK+
Sbjct: 900 ------DEEETMENNEEKKDRRKEEKE 920



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 52/209 (24%), Positives = 81/209 (38%), Gaps = 23/209 (11%)

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDR--------RTNRASRSRSRDRRKIDDQRGNLS 650
           R++      R++S S+   RSRSRS  R        R+   SRSRSRDR    D R +  
Sbjct: 3   RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYR 62

Query: 651 GN-------SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFK 703
            N        ++ +G    Q       R      +     R     +R   + R  K   
Sbjct: 63  NNRGMRRPYGYRGRGRGYYQGGGGRYHRG---GYRPVWNRRHSRSPRRGRSRSRSPKRRS 119

Query: 704 FSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSE 763
            SSQ  R + +R    + S   S S     +     SK+   + S++     + G    E
Sbjct: 120 VSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR---RGSQEKQTKKAEGEPQEE 176

Query: 764 SPGSSKEKKAKKP--KHSRSRSVEKSQRS 790
           SP  SK ++  K   +H  S S+++  +S
Sbjct: 177 SPLKSKSQEEPKDTFEHDPSESIDEFNKS 205



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 77/355 (21%), Positives = 129/355 (36%), Gaps = 57/355 (16%)

Query: 470 EAREADGDVVNEKKRTPNETTSVLEPKK--EHKEKEKQGRSRSGSSSSGSSSSNSRTSST 527
           + ++A+G+   E   +P ++ S  EPK   EH   E        S++SG           
Sbjct: 165 QTKKAEGEPQEE---SPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDN 221

Query: 528 SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA 587
           S     S    ++  S++SS S +P     HS   +P+   + S S  +S          
Sbjct: 222 SPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPS---QHSHSIQHSPE-------- 270

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI----D 643
               R    S  N   R      SP       RS ++      A R  SR R        
Sbjct: 271 ----RSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGG 326

Query: 644 DQRGNLSGNSHKH------------KGEAKEQERKKERSRSIDKDRKKKDKEREREQDKR 691
           DQ    +G   K             +G  +++E  KE+    +K R + + E +   D  
Sbjct: 327 DQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGS--EKGRAEGEWEDQEALDYF 384

Query: 692 KEKQKREEKDFKFSSQDDRLKRKRESERTFSRS-----GSISVKIIRHDSRQDSKKSTTK 746
            +K+  ++K F  S  DD    + E  R F +S     G         ++ ++  K  +K
Sbjct: 385 SDKESGKQK-FNDSEGDDT--EETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSK 441

Query: 747 DSKKHSGSDSSGRSSS-----------ESPGSSKEKKAKKPKHSRSRSVEKSQRS 790
            S K +      R              E P ++K+K  ++ K+S   +V+K  +S
Sbjct: 442 VSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQS 496



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 89/422 (21%), Positives = 146/422 (34%), Gaps = 76/422 (18%)

Query: 391 YGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKE-KEQQLLHDKQMEEEKQQTE 449
           Y S  S    S R S          R   ++KQ      E +E+  L  K  EE K   E
Sbjct: 133 YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFE 192

Query: 450 RVTKE-MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS 508
               E ++EF      S  +     A     +   R+P+  + +  P  +          
Sbjct: 193 HDPSESIDEFNKSSATSGDIWPGLSA----YDNSPRSPHSPSPIATPPSQSSSCSDAPML 248

Query: 509 RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKA 568
            +  S+  + S +S  S   S   S S S  +GSSR S   +SP       RS + TI  
Sbjct: 249 STVHSAKNTPSQHSH-SIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAP 307

Query: 569 RR-----SRSRS----------------YSRRIKIESNRA----RVKIRDRRRSNRNSIE 603
           +      SR RS                + +R   E +R     R   RD+  S     E
Sbjct: 308 QNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE 367

Query: 604 RERRR----------------------NRSPSRERRRSRSRSRDRRTNRASRSRS---RD 638
           + R                        N S   +   +    + R++  A + +S     
Sbjct: 368 KGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATAS 427

Query: 639 RRKIDDQ------RGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDK-- 690
            R  +++      + +L GN        ++  + KE    +++    KDK +E +++   
Sbjct: 428 HRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSER 487

Query: 691 ---RKEKQKREE------KD-FKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS 740
              +KE Q  E+      KD F +S    +    RE + TF     + +K+I  DS +  
Sbjct: 488 ITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDARE-KSTFREESPLRIKMIASDSHRPE 546

Query: 741 KK 742
            K
Sbjct: 547 VK 548



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 139/740 (18%), Positives = 247/740 (33%), Gaps = 125/740 (16%)

Query: 165 DYQHGAAFGPPQG--GFHPPYWQPGPP----GPPAPPQNRRERPSSFRDRQRSPIALPVK 218
           DY++      P G  G    Y+Q G      G   P  NRR   S  R R RS       
Sbjct: 60  DYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRS------- 112

Query: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKK---EKKATEDAE 275
           + P +     +R+     R    +  R  +    +      +S +SK+   ++K T+ AE
Sbjct: 113 RSPKRRSVSSQRSRSRSRRS--YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAE 170

Query: 276 GGDGPRLPQRSK--------FDSDEEEE-DTENVEAASSGKVTRSPSPV---PQEEHSDP 323
           G      P +SK        F+ D  E  D  N  +A+SG +    S     P+  HS  
Sbjct: 171 GEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPS 230

Query: 324 EMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDA---------------------- 361
            +     +        ML T      T  +  +  + +                      
Sbjct: 231 PIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNS 290

Query: 362 ---HRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHR 418
              H  + ++PAK +A  +A    +   G   +     + E +  G       DEE R  
Sbjct: 291 PIHHIPSRRSPAKTIAPQNAPRDESR--GRSSFYPDGGDQETAKTGKFLKRFTDEESRVF 348

Query: 419 IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV 478
           +  +        ++++   +K  E+ + + E   +E  ++   +++        E D   
Sbjct: 349 LLDRGNT-----RDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTE 403

Query: 479 VNEKKRTPNETTSVLEPKK----EHKEKEKQG-RSRSGSSSSGSSSSNSRTSSTSSTVSS 533
             E  R   ++    + K      H+  E++G + +S  S  G+  S+      +  +  
Sbjct: 404 ETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKE 463

Query: 534 SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRD 593
           + Y     S+      +  K K+    S   T+K    +      ++K E  +       
Sbjct: 464 TGYVVERPST------TKDKHKEEDKNSERITVK----KETQSPEQVKSEKLKDLFDYSP 513

Query: 594 RRRSNRNSIERERRRNRSPSR-----------------------ERRRSRSRSRDR---R 627
               N ++ E+   R  SP R                       +  R  S ++DR    
Sbjct: 514 PLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLAS 573

Query: 628 TNRASRSRSRDRRKIDD-----QRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK 682
           T   S  + ++ R I D     Q    +  S      +     K++  +S      ++  
Sbjct: 574 TLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFT 633

Query: 683 EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRE---SERTFSRSGSISVKIIR------ 733
             ++  ++   +QK  E   +       L++       ER F        K +R      
Sbjct: 634 SYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADL 693

Query: 734 -HDSRQDSK-KSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKK--PKHSR----SRSVE 785
            HD  +  K +S  +   K S   S  R   ++P   KE K+ K   KH R    SRS  
Sbjct: 694 RHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSS 753

Query: 786 KSQRSGKKASRKHKSKSRSR 805
            S      +SR+ K   + R
Sbjct: 754 SSASPSSPSSREEKESKKER 773



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 17/48 (35%), Positives = 28/48 (58%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GRS+S S  S  + +++    SRSRS  + +R   ++  +  S+SRSR
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSR 49



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 747 DSKKHSG-SDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
           +S+ HS  S S  +SSS S   S  +K +    SRSR+  +S+   +  SR ++   R+
Sbjct: 5   NSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRN 63


>gi|125656165 THO complex 2 [Homo sapiens]
          Length = 1593

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 89/412 (21%), Positives = 163/412 (39%), Gaps = 64/412 (15%)

Query: 456  NEFIHKE---QNSLSLLEAREADG---DVVNEKKRTPNETTSVLEPKKEHKE------KE 503
            NEF HK+   +N+++ ++     G     +    ++   +T   +  +E  +       +
Sbjct: 1184 NEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNK 1243

Query: 504  KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS-----------SSP 552
                +  G+SS+G+S SNS  +   +              +T + +             P
Sbjct: 1244 ASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP 1303

Query: 553  KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
            K ++ +   ++   K R  +S     + K E      K +    +  +   +ER R + P
Sbjct: 1304 KEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEP 1363

Query: 613  SRERRRSRS-------------------RSRDRRTNRASRSRSRDRRKIDDQRGNLSGNS 653
            SRER  ++                    +S   R++     R + RRKID        ++
Sbjct: 1364 SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423

Query: 654  HKHKG-EAKEQERK-----------KERSRSIDKDRKKKDKEREREQDKRKEKQKREEKD 701
             K    E KE   K           K + R +DK    K +ER RE++K+ EK ++E K 
Sbjct: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERK- 1482

Query: 702  FKFSSQDDR------LKRKRESERTF--SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
             +  S +DR       KR++E   T   S+  S S     + + +D +K+ +K S K  G
Sbjct: 1483 -RDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKG 1541

Query: 754  SDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
            SDS      +   S  +K+++  K    +  ++    GK+  + HKS  + R
Sbjct: 1542 SDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 67/322 (20%), Positives = 132/322 (40%), Gaps = 35/322 (10%)

Query: 431  KEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETT 490
            KE      K+ E+EK++    T      + K+       E    D      K+RTP    
Sbjct: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326

Query: 491  SVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTS------------STVSSSSYSS 538
               + KKE K K+++ ++   ++ S S+    R    S              V     + 
Sbjct: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386

Query: 539  SSGSSRTS-SRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRS 597
             SGS ++   RS  P+ ++   R +  T  +    S      I+++ + A++ I      
Sbjct: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446

Query: 598  NRNSIERER-RRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI--------DDQRGN 648
               S ERE  +++   SRER R R +  ++      R  S + R++         ++ G 
Sbjct: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGT 1506

Query: 649  LSGNSHKHKGEAK-----EQERKKERSRSIDKDRKKKDKERER--------EQDKRKEKQ 695
            +  + HK +   +     E++++K +S+S  K++     + E+        +++ R +K+
Sbjct: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE 1566

Query: 696  KREEKDFKFSSQDDRLKRKRES 717
            K E+K+ + SS     K+  +S
Sbjct: 1567 KIEKKEKRDSSGGKEEKKHHKS 1588



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 74/346 (21%), Positives = 126/346 (36%), Gaps = 75/346 (21%)

Query: 237  REGLEKMEREKQKKLEKERMEQQRSQLS-------KKEKKATEDAEGGDGPRLPQRSKFD 289
            ++G EK + E+  K EK R  ++R+  S       KKE+KA ++      P    +S  +
Sbjct: 1297 KDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356

Query: 290  SDEEEEDT------------ENVEAASSGKVTRS-PSPVPQEEHSDPEMTEEEKEYQMML 336
             + E+E +            ENV+      V+ S  SPVP+ +  +PE  ++ +      
Sbjct: 1357 REREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRR------ 1410

Query: 337  LTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDS 396
                            +I      +H    K    +L +SSA   +          +   
Sbjct: 1411 ----------------KIDTHPSPSHSSTVKDSLIELKESSAKLYIN--------HTPPP 1446

Query: 397  EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
              +  +R  +  D D    R R R+K++   RKE+++          +++    +TK   
Sbjct: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRD-----HSNNDREVPPDLTKR-- 1499

Query: 457  EFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSG 516
                KE+N             V   K  +P E+     P    K+KEK     SG     
Sbjct: 1500 ---RKEENGTM---------GVSKHKSESPCES-----PYPNEKDKEKNKSKSSGKEKGS 1542

Query: 517  SSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSR-SSSPKRKKRHSRS 561
             S  + +    SS     S        +   R SS  K +K+H +S
Sbjct: 1543 DSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKS 1588



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 8/127 (6%)

Query: 195  PQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKE 254
            P +      S  + + S   L +   PP +   K R +     +   +  RE++KK EK+
Sbjct: 1418 PSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKD 1477

Query: 255  RMEQQRSQLSKKEK---KATEDAEGGDGPRLPQRSKFDSDEE-----EEDTENVEAASSG 306
            R E++R   +   +     T+  +  +G     + K +S  E     E+D E  ++ SSG
Sbjct: 1478 RKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG 1537

Query: 307  KVTRSPS 313
            K   S S
Sbjct: 1538 KEKGSDS 1544



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 6/90 (6%)

Query: 191  PPAPPQNRRERPSSF---RDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREK 247
            PP   + R+E   +    + +  SP   P    P + D  K ++  +   +G +  + EK
Sbjct: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPY---PNEKDKEKNKSKSSGKEKGSDSFKSEK 1549

Query: 248  QKKLEKERMEQQRSQLSKKEKKATEDAEGG 277
              K+     ++ R    K EKK   D+ GG
Sbjct: 1550 MDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/219 (26%), Positives = 107/219 (48%), Gaps = 23/219 (10%)

Query: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
           R   R+ + +  +   + RDR+R   N  ERE       +R R+R R R RDR+T+R   
Sbjct: 3   RQRERKRETDRGKETERERDRQRERENQTERE-------NRHRQRDRHRERDRQTDR--- 52

Query: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDR-KKKDKEREREQDKRK 692
            + R+R+K  D++      + +     +E++R++ER R  D++R K +D+ER+RE D+ +
Sbjct: 53  EKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNR 112

Query: 693 EKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS 752
           E+ ++  ++     +D + +R+R+ ER   R         R   RQ  +K  T D ++  
Sbjct: 113 ERNRKGGRE-----RDKQTERERDRERERQRQRE------RERQRQRERKRET-DRERQR 160

Query: 753 GSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSG 791
            ++   R         KE+K KK +  R    ++    G
Sbjct: 161 WAEREERKKERKKERKKERKEKKKEEKRREDKKRKWGEG 199



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 57/205 (27%), Positives = 93/205 (45%), Gaps = 10/205 (4%)

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP 552
           +E ++E K +  +G+             N                    + R   R    
Sbjct: 1   MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60

Query: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
           +R ++  R R    +  R R R   R  K +++R R K RDR R  +   +R R RNR  
Sbjct: 61  ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRER--KRETDRNRERNRKG 118

Query: 613 SRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRS 672
            RER +   R RDR   R  R R R+R++   QR        + +  A+ +ERKKER   
Sbjct: 119 GRERDKQTERERDRERER-QRQRERERQR---QRERKRETDRERQRWAEREERKKERK-- 172

Query: 673 IDKDRKKKDKEREREQDKRKEKQKR 697
             K+RKK+ KE+++E+ +R++K+++
Sbjct: 173 --KERKKERKEKKKEEKRREDKKRK 195



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 55/202 (27%), Positives = 105/202 (51%), Gaps = 28/202 (13%)

Query: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
           +R+++    R    +  R R R    + + E+   R + RDR R      +RE+ R R  
Sbjct: 4   QRERKRETDRGKETERERDRQRERENQTEREN---RHRQRDRHRERDRQTDREKERERQK 60

Query: 613 SRERRRSRSRSRDRRTNRA-SRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSR 671
            R+R+R R R  +R T R   R R R+R++  D          + + + +++ERK+E  R
Sbjct: 61  ERDRQRQRERETERETERQRERQRQRERKRQTD----------RERDKDRDRERKRETDR 110

Query: 672 SIDKDRK---KKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSIS 728
           + +++RK   ++DK+ ERE+D+ +E+Q++ E++     +  + +RKRE++R   R     
Sbjct: 111 NRERNRKGGRERDKQTERERDRERERQRQRERE-----RQRQRERKRETDRERQRWAE-- 163

Query: 729 VKIIRHDSRQDSKKSTTKDSKK 750
               R + +++ KK   K+ K+
Sbjct: 164 ----REERKKERKKERKKERKE 181



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 53/174 (30%), Positives = 95/174 (54%), Gaps = 15/174 (8%)

Query: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIER--ERRRNR 610
           ++++R +++       +R R R   R+   E  R R K RDR+R      ER  ER+R R
Sbjct: 23  RQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRER 82

Query: 611 SPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
              RER+R   R RD+  +R  R R  DR +  +++G    +    +   +E+ER+++R 
Sbjct: 83  QRQRERKRQTDRERDKDRDR-ERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRE 141

Query: 671 RSIDKDRKKK---DKERER--EQDKRKEKQKREEKDFKFSSQDDRLKRKRESER 719
           R   + R++K   D+ER+R  E+++RK+++K+E K        +R ++K+E +R
Sbjct: 142 RERQRQRERKRETDRERQRWAEREERKKERKKERK-------KERKEKKKEEKR 188



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 51/204 (25%), Positives = 100/204 (49%), Gaps = 22/204 (10%)

Query: 603 ERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKE 662
           ER+R  +R    ER R R R R+ +T R +R R RDR +  D++ +            KE
Sbjct: 6   ERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTD----------REKE 55

Query: 663 QERKKERSRSIDKDRK-KKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTF 721
           +ER+KER R   ++R+ +++ ER+RE+ +++E++++ +++     +D   +RKRE++R  
Sbjct: 56  RERQKERDRQRQRERETERETERQRERQRQRERKRQTDRE---RDKDRDRERKRETDRNR 112

Query: 722 SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRS 781
            R+        R   R+  K++  +  ++        R         +E   ++ + +  
Sbjct: 113 ERN--------RKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAER 164

Query: 782 RSVEKSQRSGKKASRKHKSKSRSR 805
              +K ++  +K  RK K K   R
Sbjct: 165 EERKKERKKERKKERKEKKKEEKR 188



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 65/295 (22%), Positives = 106/295 (35%), Gaps = 101/295 (34%)

Query: 399 ERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEF 458
           ER       +D   E  R R RQ++     + + +    D+  E + +QT+R        
Sbjct: 2   ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERD-RQTDR-------- 52

Query: 459 IHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSS 518
             KE+        R+ + D   +++R     T     ++  +E+++Q             
Sbjct: 53  -EKERE-------RQKERDRQRQRERETERETERQRERQRQRERKRQ------------- 91

Query: 519 SSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR 578
                                  + R   +    +RK+   R+R    K  R R +   R
Sbjct: 92  -----------------------TDRERDKDRDRERKRETDRNRERNRKGGRERDKQTER 128

Query: 579 RIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
                        RDR        ERER+R R   R+R+R R R  DR   R +    R+
Sbjct: 129 E------------RDR--------ERERQRQRERERQRQRERKRETDRERQRWA---ERE 165

Query: 639 RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693
            RK                     +ERKKER     K+RK+K KE +R +DK+++
Sbjct: 166 ERK---------------------KERKKERK----KERKEKKKEEKRREDKKRK 195



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 31/153 (20%), Positives = 71/153 (46%), Gaps = 14/153 (9%)

Query: 664 ERKKERSRSIDKDR---KKKDKERERE-----QDKRKEKQKREEKDFKFSSQDDRLKRK- 714
           ER++ER R  D+ +   +++D++RERE     +++ +++ +  E+D +   + +R ++K 
Sbjct: 2   ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61

Query: 715 RESERTFSRSGSISVKIIRHDSRQDSKKSTT-----KDSKKHSGSDSSGRSSSESPGSSK 769
           R+ +R   R      +  R   RQ  +K  T     KD  +    ++         G  +
Sbjct: 62  RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121

Query: 770 EKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKS 802
             K  + +  R R  ++ +   ++  R+ K ++
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRET 154



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 30/158 (18%), Positives = 72/158 (45%), Gaps = 15/158 (9%)

Query: 661 KEQERKKERSRSIDKDRKK-KDKERE---------REQDKRKEKQK---REEKDFKFSSQ 707
           +++ERK+E  R  + +R++ + +ERE         R++D+ +E+ +   RE++  +   +
Sbjct: 3   RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62

Query: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767
           D + +R+RE+ER   R      +  R   RQ  ++      ++        R  +   G 
Sbjct: 63  DRQRQRERETERETERQRERQRQ--RERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120

Query: 768 SKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
            ++K+ ++ +        + +R  ++   + +   R R
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRER 158


>gi|239756568 PREDICTED: similar to BCL2-associated transcription
           factor 1 [Homo sapiens]
          Length = 869

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 91/283 (32%), Positives = 122/283 (43%), Gaps = 32/283 (11%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR--RIKIE 583
           S S + SS S S S  SSR+ SRS S  RKKR+ RSRS T    RSR R YSR  R    
Sbjct: 4   SNSRSHSSRSKSRSQSSSRSRSRSHS--RKKRY-RSRSRTYSRSRSRDRMYSRDYRRDYR 60

Query: 584 SNRARVKIRDRRRSNRNSIER--------------ERRRNRSPSRERRRSRSRSRDRRTN 629
           +NRA  +    R   R   +                RR +RSP   R RSRSRS  RR+ 
Sbjct: 61  NNRAMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSP--RRGRSRSRSPKRRSV 118

Query: 630 RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
            + RSRSR RR     R   S +S      +K    K+  S+  +K  KK + E + E  
Sbjct: 119 SSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQ--EKQTKKAEGELQEESP 176

Query: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
            + + Q+  +  F+  S         ES   F++S +    I    S  D    +     
Sbjct: 177 LKSKSQEEPKDTFEHDSS--------ESIDEFNKSSATCGDIWPGLSAYDXSPRSPHSPS 228

Query: 750 KHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS-QRSG 791
             +   S   S S++P  S    AK      S S++ S +RSG
Sbjct: 229 PIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSG 271



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 88/398 (22%), Positives = 160/398 (40%), Gaps = 52/398 (13%)

Query: 390 GYGSGDSEDERSDRGSESSD------------TDDEELRHRIRQKQEAFWRKEKEQQLLH 437
           G  + ++ED R  R S  +D            T++E L+++ +   +     +  ++  +
Sbjct: 397 GDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKN 456

Query: 438 DKQMEE----EKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
           DK  E     E+  T   TK+ ++   K    +++ +  ++   V +EK +   + +  L
Sbjct: 457 DKHKETGYVVERPST---TKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPL 513

Query: 494 EPKKEHKEKE---KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT-SSRS 549
               + +EK    ++   R    +S S     +       +  S+  +S    R  +S  
Sbjct: 514 HKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTL 573

Query: 550 SSPKRKKRHSRSRSPTIK---ARRSRSRSYSRRI--------KIESNRARVKIRDRRRSN 598
               +K++  RS    IK   A +S S S+ + I        +     A + + +R  S 
Sbjct: 574 VHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSY 633

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKG 658
           + + E    R +SP   RR   S S  R+          D R   ++R     N    KG
Sbjct: 634 QKATEEHSTRQKSPEIHRRIDISPSTLRK----------DTRLAGEERVFKEENQ---KG 680

Query: 659 EAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE----KQKREEKDFK-FSSQDDRLKR 713
           + K +    +    ID  RK++ KER   +  R+     KQ++  KD+K + S  D  K 
Sbjct: 681 DKKLRCDSADLRHDIDHRRKERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKH 740

Query: 714 KRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
           KRE + + S S S S         ++SKK   ++ K H
Sbjct: 741 KREQDHSLSSSSSASPSSPSSREEKESKKEREEEFKTH 778



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 137/711 (19%), Positives = 260/711 (36%), Gaps = 116/711 (16%)

Query: 108 PWMPPTPGPMDIVPPSEDSNSQDSGEFAPDN--RHIFNQNNHNFGGPPDNFAVGPVNQFD 165
           P  P +P P+   PPS+ S+  D+   +  +  ++  +Q++H+    P+    G V    
Sbjct: 221 PRSPHSPSPI-ATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGS 279

Query: 166 YQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQID 225
            ++                        +P QN    P      +RSP      Q  P+ +
Sbjct: 280 SRY------------------------SPSQNS---PIHHIPSRRSPAKTIAPQNAPRDE 312

Query: 226 AVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQR 285
           +   R   ++  +G ++   +  K L++   E+ R  L  +     ++A    G      
Sbjct: 313 S---RGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE---- 365

Query: 286 SKFDSDEEEEDTENVEAAS---SGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLT---K 339
            K  ++ E ED E ++  S   SGK   + S     E  D E TE+ ++++  +L    K
Sbjct: 366 -KGRAEGEWEDQEALDYFSDKESGKQKFNDS-----EGDDTEETEDYRQFRKSVLADQGK 419

Query: 340 MLLTEILLDVTDEEIYYVAK---------DAHRKATKAPAKQLAQSSALASLTGLGGLGG 390
              T    +  +E + Y +K         D  R+      K+        S T       
Sbjct: 420 SFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNDKHKETGYVVERPSTTK------ 473

Query: 391 YGSGDSEDERSDRGSESSDTDDEE----------------LRHRIRQKQEAFWRKEKEQQ 434
                 ED+ S+R +   +T   E                L   +  ++++ +R+E   +
Sbjct: 474 -DKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLR 532

Query: 435 LLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLE 494
           +   K +  +  + E   K     +       SL + R     +V+  K+   E  S+ +
Sbjct: 533 I---KMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKE-QEFRSIFD 588

Query: 495 PKKEHKEKEKQGRSRSGSSSSGSSS-----SNSRTSSTSSTVSSSSYSSSSGSSRTSSRS 549
               H +  +  +S S S      S           S + T+S    S    +   S+R 
Sbjct: 589 ----HIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSYQKATEEHSTRQ 644

Query: 550 SSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRN 609
            SP+  +R   S  P+   + +R     R  K E+ +   K+R      R+ I+  R+  
Sbjct: 645 KSPEIHRRIDIS--PSTLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRRK-- 700

Query: 610 RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKER 669
                ER + R  S+  R +R SR + +  +   + +     + HK + +          
Sbjct: 701 -----ERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKHKRE-QDHSLSSSSSA 754

Query: 670 SRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQ------DDRLKRKRESERTFSR 723
           S S    R++K+ ++ERE++ +   + +E   F   S+      DDR     +    +++
Sbjct: 755 SPSSPSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFHDDR----DDGVDYWAK 810

Query: 724 SGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSG--RSSSESPGSSKEKK 772
            G       R   R + KKS +     H      G      E+  +++EKK
Sbjct: 811 RGRGRGTFQRGRGRFNFKKSGSSPKWNHDKYQGDGIVEDEEETMENNEEKK 861



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 52/207 (25%), Positives = 81/207 (39%), Gaps = 21/207 (10%)

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDR------RTNRASRSRSRDRRKIDDQRGNLSGN 652
           R++      R++S S+   RSRSRS  R      R+   SRSRSRDR    D R +   N
Sbjct: 3   RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNN 62

Query: 653 -------SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705
                   ++ +G    Q       R      +     R     +R   + R  K    S
Sbjct: 63  RAMRRPYGYRGRGRGYYQGGGGRYHRG---GYRPVWNRRHSRSPRRGRSRSRSPKRRSVS 119

Query: 706 SQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESP 765
           SQ  R + +R    + S   S S     +     SK+   + S++     + G    ESP
Sbjct: 120 SQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR---RGSQEKQTKKAEGELQEESP 176

Query: 766 GSSKEKKAKKP--KHSRSRSVEKSQRS 790
             SK ++  K   +H  S S+++  +S
Sbjct: 177 LKSKSQEEPKDTFEHDSSESIDEFNKS 203



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 46/179 (25%), Positives = 73/179 (40%), Gaps = 28/179 (15%)

Query: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711
           NS  H   +K + +   RSRS    RKK+ + R R   + + + +   +D++   +++R 
Sbjct: 5   NSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNNRA 64

Query: 712 KRKRESER------------TFSRSGSISVKIIRHD-------SRQDS-KKSTTKDSKKH 751
            R+    R             + R G   V   RH        SR  S K+ +    +  
Sbjct: 65  MRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSR 124

Query: 752 SGSDSSGRSSSESPGSSKEKK----AKKPKHSRSRSVEKSQRSGKKASRKH---KSKSR 803
           S S  S R SS SP SS  +     +K P   R  S EK  +  +   ++    KSKS+
Sbjct: 125 SRSRRSYR-SSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGELQEESPLKSKSQ 182



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 76/355 (21%), Positives = 129/355 (36%), Gaps = 57/355 (16%)

Query: 470 EAREADGDVVNEKKRTPNETTSVLEPKK--EHKEKEKQGRSRSGSSSSGSSSSNSRTSST 527
           + ++A+G++  E   +P ++ S  EPK   EH   E        S++ G           
Sbjct: 163 QTKKAEGELQEE---SPLKSKSQEEPKDTFEHDSSESIDEFNKSSATCGDIWPGLSAYDX 219

Query: 528 SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA 587
           S     S    ++  S++SS S +P     HS   +P+   + S S  +S          
Sbjct: 220 SPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPS---QHSHSIQHSPE-------- 268

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI----D 643
               R    S  N   R      SP       RS ++      A R  SR R        
Sbjct: 269 ----RSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGG 324

Query: 644 DQRGNLSGNSHKH------------KGEAKEQERKKERSRSIDKDRKKKDKEREREQDKR 691
           DQ    +G   K             +G  +++E  KE+    +K R + + E +   D  
Sbjct: 325 DQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGS--EKGRAEGEWEDQEALDYF 382

Query: 692 KEKQKREEKDFKFSSQDDRLKRKRESERTFSRS-----GSISVKIIRHDSRQDSKKSTTK 746
            +K+  ++K F  S  DD    + E  R F +S     G         ++ ++  K  +K
Sbjct: 383 SDKESGKQK-FNDSEGDDT--EETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSK 439

Query: 747 DSKKHSGSDSSGRSSS-----------ESPGSSKEKKAKKPKHSRSRSVEKSQRS 790
            S K +      R              E P ++K+K  ++ K+S   +V+K  +S
Sbjct: 440 VSLKGNRESDGFREEKNDKHKETGYVVERPSTTKDKHKEEDKNSERITVKKETQS 494



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 87/427 (20%), Positives = 165/427 (38%), Gaps = 47/427 (11%)

Query: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
           S+++ S++G    + +D+E       K E+  +K  + +    ++ E+ +Q  + V  + 
Sbjct: 359 SKEKGSEKGRAEGEWEDQEALDYFSDK-ESGKQKFNDSEGDDTEETEDYRQFRKSVLADQ 417

Query: 456 NEFIH------------KEQNSLSLLEAREADGDVVNEKKRTPNETTSVLE----PKKEH 499
            +               K ++ +SL   RE+DG    EK     ET  V+E     K +H
Sbjct: 418 GKSFATASHRNTEEEGLKYKSKVSLKGNRESDG-FREEKNDKHKETGYVVERPSTTKDKH 476

Query: 500 KEKEKQGRSRSGSSSSGSSSS-NSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKR- 557
           KE++K     +    + S     S         S   + +     +++ R  SP R K  
Sbjct: 477 KEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMI 536

Query: 558 HSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR--NSIERER--RRNRSPS 613
            S S  P +K + +           +SNR     +DR  ++   +S+++E+  R      
Sbjct: 537 ASDSHRPEVKLKMAPVPLD------DSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHI 590

Query: 614 RERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE----- 668
           +  + S+S S     +  S       +        LS     ++   +E   +++     
Sbjct: 591 KLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSERFTSYQKATEEHSTRQKSPEIH 650

Query: 669 RSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQD-----DRLKRKRESERTFSR 723
           R   I     +KD     E+   KE+ ++ +K  +  S D     D  +++R  ER  S+
Sbjct: 651 RRIDISPSTLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRRKERSKERGDSK 710

Query: 724 SGSISVKIIRHDSRQDSKKS--TTKDSKKHS-----GSDSSGRSSSESPGSSKEKKAKKP 776
               S    + +      K   + KD  KH         SS  +S  SP S +EK++KK 
Sbjct: 711 GSRESRGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSLSSSSSASPSSPSSREEKESKKE 770

Query: 777 KHSRSRS 783
           +    ++
Sbjct: 771 REEEFKT 777



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 97/464 (20%), Positives = 160/464 (34%), Gaps = 48/464 (10%)

Query: 244 EREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAA 303
           E E  K   K  ++  R     +E+K  +  E G     P  +K    EE++++E +   
Sbjct: 430 EEEGLKYKSKVSLKGNRESDGFREEKNDKHKETGYVVERPSTTKDKHKEEDKNSERITVK 489

Query: 304 SSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
              K T+SP  V  E+  D           +    K    E     +   I  +A D+HR
Sbjct: 490 ---KETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFRE----ESPLRIKMIASDSHR 542

Query: 364 KATK---APAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG--------SESSDTDD 412
              K   AP   L  S+  ASLT    L        + E+  R           S  T +
Sbjct: 543 PEVKLKMAPV-PLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSE 601

Query: 413 EELRHRI----RQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE---QNS 465
             ++H +      K++ F   +     L ++    +K   E  T++ +  IH+      S
Sbjct: 602 SFIQHIVSLVHHVKEQYF---KSAAMTLSERFTSYQKATEEHSTRQKSPEIHRRIDISPS 658

Query: 466 LSLLEAREADGDVVNEKKRTPNE-----TTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSS 520
               + R A  + V +++    +      ++ L    +H+ KE   RS+    S GS  S
Sbjct: 659 TLRKDTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDHRRKE---RSKERGDSKGSRES 715

Query: 521 NSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRI 580
                   +      Y S    S+        KR++ HS S S +       SR      
Sbjct: 716 RGSRKQEKTPKDYKEYKSYKDDSK-------HKREQDHSLSSSSSASPSSPSSREEKESK 768

Query: 581 KIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRR 640
           K      +     +  S    + R R        +R         R   R +  R R R 
Sbjct: 769 KEREEEFKTHHEMKEYSGFAGVSRPRGTFHD---DRDDGVDYWAKRGRGRGTFQRGRGRF 825

Query: 641 KIDDQRGNLSGNSHKHKGEA-KEQERKKERSRSIDKDRKKKDKE 683
                  +   N  K++G+   E E +   +    KDR K++KE
Sbjct: 826 NFKKSGSSPKWNHDKYQGDGIVEDEEETMENNEEKKDRCKEEKE 869



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 23/66 (34%), Positives = 32/66 (48%)

Query: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556
           + H    ++GRSRS S    S SS    S +  +  SS    SS S  +S  S SP  K+
Sbjct: 97  RRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR 156

Query: 557 RHSRSR 562
           R S+ +
Sbjct: 157 RGSQEK 162



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 5/81 (6%)

Query: 484 RTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSS 543
           R+P    S     K      ++ RSR     S  S  +SR+  +SS+ SSS YS S  S 
Sbjct: 101 RSPRRGRSRSRSPKRRSVSSQRSRSR-----SRRSYRSSRSPRSSSSRSSSPYSKSPVSK 155

Query: 544 RTSSRSSSPKRKKRHSRSRSP 564
           R  S+    K+ +   +  SP
Sbjct: 156 RRGSQEKQTKKAEGELQEESP 176



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 16/48 (33%), Positives = 27/48 (56%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GRS+S S  S  + +++    SRSRS  + +R   ++    +S+SR R
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDR 49


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 52/207 (25%), Positives = 100/207 (48%), Gaps = 11/207 (5%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR------- 578
           +T   + S S+ S   + R S R    + +++  R R    K  R +     R       
Sbjct: 14  NTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGK 73

Query: 579 ---RIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
              R + E  + R + R++ R  R   +++R R +   RER++ + R    R N+  R R
Sbjct: 74  ERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRER 133

Query: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE-RSRSIDKDRKKKDKEREREQDKRKEK 694
            R +R+   +R        + K E K ++RKKE R +  +++RK++ KERER++ + ++K
Sbjct: 134 KRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKK 193

Query: 695 QKREEKDFKFSSQDDRLKRKRESERTF 721
           ++++E+  K   + DR   ++   + F
Sbjct: 194 ERKKERRKKKERKKDRKTDRQTDSQVF 220



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 66/235 (28%), Positives = 94/235 (40%), Gaps = 44/235 (18%)

Query: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPK 553
           E KKE +E+EK+ R R                                  R   +    K
Sbjct: 35  ERKKERREREKRKREREKERK-----------------------------RERGKKEKKK 65

Query: 554 RKKRH-----SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRR 608
           RKKR       R R    K R+ R     R+ K E  +   K R RR   +    +ER R
Sbjct: 66  RKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERER 125

Query: 609 NRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE 668
                RER+R + R + RR  R    R ++R K + +R        + K E   +ERKKE
Sbjct: 126 ENKQRRERKRKKRRKKKRRKER---KREKERGKRERKRKKRKKEEREKKRERNRKERKKE 182

Query: 669 RSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSR 723
           R R       K+ +ER++E+ K + K+K  +KD K   Q D    +   E  F+R
Sbjct: 183 RER-------KERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNR 230



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 62/194 (31%), Positives = 95/194 (48%), Gaps = 13/194 (6%)

Query: 569 RRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRT 628
           +R   R   RR + +  R R K R R R  +   +R ++R R   RER+R + R + R+ 
Sbjct: 31  QRESERKKERREREKRKREREKERKRERGKKEKKKR-KKRERGKERERKR-KEREKQRKE 88

Query: 629 NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQER--KKERSRSIDKDRKK---KDKE 683
            R    R R + K   +R        K K E KE+ER  K+ R R   K RKK   K+++
Sbjct: 89  RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148

Query: 684 REREQDKRKEKQKREEKDFKFSSQD-DRLKRKRESERTFSRSGSISVKIIRHDSRQDSKK 742
           RE+E+ KR+ K+K+ +K+ +   ++ +R +RK+E ER   R      K       +  KK
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK-----KERRKKK 203

Query: 743 STTKDSKKHSGSDS 756
              KD K    +DS
Sbjct: 204 ERKKDRKTDRQTDS 217



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 57/241 (23%), Positives = 107/241 (44%), Gaps = 43/241 (17%)

Query: 580 IKIESNRARVKIRDR--------------RRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
           +K  S+RA VK+                 +R +    ER  R  R   RE+ R R R + 
Sbjct: 2   VKAISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKK 61

Query: 626 RRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRK-----KK 680
            +  R  R R ++R +   +R        K + E +E+ER+K +     ++RK     ++
Sbjct: 62  EKKKRKKRERGKERERKRKER-------EKQRKERREKERRKRKKEKKKRERKQRGRRER 114

Query: 681 DKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS 740
            K++ER++ +R+ KQ+RE K  K   +  R +RKRE ER             + + ++  
Sbjct: 115 KKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERG------------KRERKRKK 162

Query: 741 KKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKS 800
           +K   ++ K+        R   +     KE++ +K +  + R  +K ++  +K  R+  S
Sbjct: 163 RKKEEREKKR-----ERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDS 217

Query: 801 K 801
           +
Sbjct: 218 Q 218



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 50/200 (25%), Positives = 92/200 (46%), Gaps = 21/200 (10%)

Query: 603 ERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKE 662
           E ER++ R    +R+R R + R R   +  + + + R +         G   + K + +E
Sbjct: 33  ESERKKERREREKRKREREKERKRERGKKEKKKRKKRER---------GKERERKRKERE 83

Query: 663 QERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFS 722
           ++RK+ R +   K RKK+ K+RER+Q  R+E++K++E+  +      R +RKR+  R   
Sbjct: 84  KQRKERREKERRK-RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKK 142

Query: 723 RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSR 782
           R         R + +++ ++   K  +K        R         + KK ++ K  R R
Sbjct: 143 R---------RKERKREKERG--KRERKRKKRKKEEREKKRERNRKERKKERERKERRER 191

Query: 783 SVEKSQRSGKKASRKHKSKS 802
             E+ +   KK  RK   K+
Sbjct: 192 KKERKKERRKKKERKKDRKT 211



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 46/181 (25%), Positives = 90/181 (49%), Gaps = 13/181 (7%)

Query: 626 RRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERE 685
           R + R    R R++RK + ++        + K E  ++E+KK + R   K+R++K KERE
Sbjct: 32  RESERKKERREREKRKREREK--------ERKRERGKKEKKKRKKRERGKERERKRKERE 83

Query: 686 REQDKRKEKQKR---EEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKK 742
           +++ +R+EK++R   +EK  +   Q  R +RK++ ER      +   +  +   R+  KK
Sbjct: 84  KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR--KK 141

Query: 743 STTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKS 802
              K+ K+        R   +     +EKK ++ +  R +  E+ +R  +K  RK + + 
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201

Query: 803 R 803
           +
Sbjct: 202 K 202



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 39/145 (26%), Positives = 76/145 (52%), Gaps = 4/145 (2%)

Query: 661 KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT 720
           +E ERKKER R  +K +++++KER+RE+ K KEK+KR++++     + +R +++RE +R 
Sbjct: 32  RESERKKER-REREKRKREREKERKRERGK-KEKKKRKKRE--RGKERERKRKEREKQRK 87

Query: 721 FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR 780
             R      +      R+  ++   +  KK    +    +        K+++ KK +  R
Sbjct: 88  ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147

Query: 781 SRSVEKSQRSGKKASRKHKSKSRSR 805
            R  E+ +R  K+  RK + + + R
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKR 172



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 58/256 (22%), Positives = 99/256 (38%), Gaps = 59/256 (23%)

Query: 445 KQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEK 504
           K  T+R ++   E   +E+      + R+ +     +KKR   E     E +++ KE+EK
Sbjct: 27  KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGK--ERERKRKEREK 84

Query: 505 QGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSP 564
           Q + R             +                        R    ++KK+  + R  
Sbjct: 85  QRKERREKERRKRKKEKKKRER-------------------KQRGRRERKKKKERKERER 125

Query: 565 TIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRS- 623
             K RR R R   R+ K    R R K R +R       ER+R++ +   RE++R R+R  
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKERGKR-------ERKRKKRKKEEREKKRERNRKE 178

Query: 624 -RDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK 682
            +  R  +  R R ++R+                    KE+ +KKER         KKD+
Sbjct: 179 RKKERERKERRERKKERK--------------------KERRKKKER---------KKDR 209

Query: 683 EREREQDKRKEKQKRE 698
           + +R+ D +  +  RE
Sbjct: 210 KTDRQTDSQVFRPLRE 225



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 57/242 (23%)

Query: 395 DSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHD-KQMEEEKQQTERVTK 453
           +SE ++  R  E    + E+ R R R K+E   RK++E+    + K+ E EKQ+ ER  K
Sbjct: 33  ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92

Query: 454 EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSS 513
           E  +   KE+      +    +     E+K    E     E K++ + K+K+ + R    
Sbjct: 93  ERRKR-KKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151

Query: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
             G                                    KRKKR    R    + +R R+
Sbjct: 152 ERGKRER--------------------------------KRKKRKKEER----EKKRERN 175

Query: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
           R                 ++R++       RER++ R   +ERR+ + R +DR+T+R + 
Sbjct: 176 R-----------------KERKKERERKERRERKKER--KKERRKKKERKKDRKTDRQTD 216

Query: 634 SR 635
           S+
Sbjct: 217 SQ 218



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 36/185 (19%), Positives = 65/185 (35%)

Query: 398 DERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNE 457
           +   +R  E    + ++ + R R K+    RKE+E+Q    ++ E  K++ E+  +E  +
Sbjct: 49  EREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQ 108

Query: 458 FIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGS 517
              +E+      + RE +     E+KR         + +K  KE+ K+ R R        
Sbjct: 109 RGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEER 168

Query: 518 SSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYS 577
                R                    R   R    +RKK     R    +  R    S  
Sbjct: 169 EKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAF 228

Query: 578 RRIKI 582
            R+ +
Sbjct: 229 NRVTV 233



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 30/121 (24%), Positives = 53/121 (43%), Gaps = 31/121 (25%)

Query: 685 EREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKST 744
           +RE +++KE+++RE++           KR+RE ER                 R+  KK  
Sbjct: 31  QRESERKKERREREKR-----------KREREKER----------------KRERGKKEK 63

Query: 745 TKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
            K  K+  G +   +         K++K ++ K  R R  EK +R  K+  R+ + K + 
Sbjct: 64  KKRKKRERGKERERKRKER----EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE 119

Query: 805 R 805
           R
Sbjct: 120 R 120



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 39/229 (17%), Positives = 88/229 (38%), Gaps = 35/229 (15%)

Query: 233 PAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDE 292
           P   RE   K ER +++K ++ER ++++ +  KKEKK  +  E G      ++ +    +
Sbjct: 28  PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87

Query: 293 EEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDE 352
           E  + E  +     K         +E     E  E E+E +     K             
Sbjct: 88  ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK------------- 134

Query: 353 EIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDD 412
                 K   +K  +   K+  +                  G  E +R  R  E  +   
Sbjct: 135 -----RKKRRKKKRRKERKREKE-----------------RGKRERKRKKRKKEEREKKR 172

Query: 413 EELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHK 461
           E  R   ++++E   R+E++++   +++ ++E+++  +  ++ +  + +
Sbjct: 173 ERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFR 221



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 1/100 (1%)

Query: 199 RERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQ 258
           RER    R++QR       +++  + +  KR       RE  +K ER+++++  K+R E+
Sbjct: 75  RERKRKEREKQRKERREKERRKRKK-EKKKRERKQRGRRERKKKKERKERERENKQRRER 133

Query: 259 QRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTE 298
           +R +  KK+++     E   G R  +R K   +E E+  E
Sbjct: 134 KRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRE 173



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 14/136 (10%)

Query: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
           + RRER    R+R++       K+E  + +  KR+          ++ EREKQ+K  +E+
Sbjct: 38  KERREREKRKREREKER-----KRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92

Query: 256 MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPV 315
             ++R    KKEKK  E  + G   R     K   + +E + EN +     +  R     
Sbjct: 93  ERRKR----KKEKKKRERKQRGRRER-----KKKKERKERERENKQRRERKRKKRRKKKR 143

Query: 316 PQEEHSDPEMTEEEKE 331
            +E   + E  + E++
Sbjct: 144 RKERKREKERGKRERK 159



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 30/137 (21%), Positives = 58/137 (42%), Gaps = 2/137 (1%)

Query: 196 QNRRERPSSF-RDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKE 254
           + +RER     R+R +       K+E  +    KR+      +E  EK  R K+KK +K+
Sbjct: 45  KRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERR-KRKKEKKK 103

Query: 255 RMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314
           R  +QR +  +K+KK  ++ E  +  R  ++ K    ++       E     +  +    
Sbjct: 104 RERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKR 163

Query: 315 VPQEEHSDPEMTEEEKE 331
             +E     E   +E++
Sbjct: 164 KKEEREKKRERNRKERK 180


>gi|117938251 BCL2-associated transcription factor 1 isoform 2 [Homo
           sapiens]
          Length = 869

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 94/283 (33%), Positives = 128/283 (45%), Gaps = 32/283 (11%)

Query: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSR--RIKIE 583
           S S + SS S S S  SSR+ SRS S  RKKR+ RSRS T    RSR R YSR  R    
Sbjct: 4   SNSRSHSSRSKSRSQSSSRSRSRSHS--RKKRY-RSRSRTYSRSRSRDRMYSRDYRRDYR 60

Query: 584 SNRARVKIRDRRRSNRNSIER--------------ERRRNRSPSRERRRSRSRSRDRRTN 629
           +NR   +    R   R   +                RR +RSP   R RSRSRS  RR+ 
Sbjct: 61  NNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSP--RRGRSRSRSPKRRSV 118

Query: 630 RASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
            + RSRSR RR     R   S +S      +K    K+  S+  +K  KK + E  +E+ 
Sbjct: 119 SSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQ--EKQTKKAEGE-PQEES 175

Query: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSK 749
             K K + E KD   + + D  +   E  ++ + SG I   +  +D+   S  S +  + 
Sbjct: 176 PLKSKSQEEPKD---TFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIAT 232

Query: 750 KHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKS-QRSG 791
             S S     S S++P  S    AK      S S++ S +RSG
Sbjct: 233 PPSQSS----SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSG 271



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 87/399 (21%), Positives = 161/399 (40%), Gaps = 54/399 (13%)

Query: 390 GYGSGDSEDERSDRGSESSD------------TDDEELRHRIR-----QKQEAFWRKEKE 432
           G  + ++ED R  R S  +D            T++E L+++ +      ++   +R+EK 
Sbjct: 397 GDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKN 456

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            +L     + E    T+   KE +    K    +++ +  ++   V +EK +   + +  
Sbjct: 457 YKLKETGYVVERPSTTKDKHKEED----KNSERITVKKETQSPEQVKSEKLKDLFDYSPP 512

Query: 493 LEPKKEHKEKE---KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT-SSR 548
           L    + +EK    ++   R    +S S     +       +  S+  +S    R  +S 
Sbjct: 513 LHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLAST 572

Query: 549 SSSPKRKKRHSRSRSPTIK---ARRSRSRSYSRRI--------KIESNRARVKIRDRRRS 597
                +K++  RS    IK   A +S S S+ + I        +     A + + +R  S
Sbjct: 573 LVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTS 632

Query: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHK 657
            + + E    R +SP   RR   S S  R+  R +     + R   ++           K
Sbjct: 633 YQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAG----EERVFKEEN---------QK 679

Query: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE----KQKREEKDFK-FSSQDDRLK 712
           G+ K +    +    ID+ RK++ KER   +  R+     KQ++  KD+K + S  D  K
Sbjct: 680 GDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSK 739

Query: 713 RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKH 751
            KRE + + S S S S         ++SKK   ++ K H
Sbjct: 740 HKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTH 778



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 120/624 (19%), Positives = 231/624 (37%), Gaps = 107/624 (17%)

Query: 106 DQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDN--RHIFNQNNHNFGGPPDNFAVGPVNQ 163
           + P  P +P P+   PPS+ S+  D+   +  +  ++  +Q++H+    P+    G V  
Sbjct: 219 NSPRSPHSPSPI-ATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGN 277

Query: 164 FDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQ 223
              ++                        +P QN    P      +RSP      Q  P+
Sbjct: 278 GSSRY------------------------SPSQNS---PIHHIPSRRSPAKTIAPQNAPR 310

Query: 224 IDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLP 283
            ++   R   ++  +G ++   +  K L++   E+ R  L  +     ++A    G    
Sbjct: 311 DES---RGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE-- 365

Query: 284 QRSKFDSDEEEEDTENVEAAS---SGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLT-- 338
              K  ++ E ED E ++  S   SGK   + S     E  D E TE+ ++++  +L   
Sbjct: 366 ---KGRAEGEWEDQEALDYFSDKESGKQKFNDS-----EGDDTEETEDYRQFRKSVLADQ 417

Query: 339 -KMLLTEILLDVTDEEIYYVAK---------DAHRKATKAPAKQLAQSSALASLTGLGGL 388
            K   T    +  +E + Y +K         D  R+      K+        S T     
Sbjct: 418 GKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTK---- 473

Query: 389 GGYGSGDSEDERSDRGSESSDTDDEE----------------LRHRIRQKQEAFWRKEKE 432
                   ED+ S+R +   +T   E                L   +  ++++ +R+E  
Sbjct: 474 ---DKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESP 530

Query: 433 QQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSV 492
            ++   K +  +  + E   K     +       SL + R     +V+  K+   E  S+
Sbjct: 531 LRI---KMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKE-QEFRSI 586

Query: 493 LEPKKEHKEKEKQGRSRSGSSSSGSSS-----SNSRTSSTSSTVSSSSYSSSSGSSRTSS 547
            +    H +  +  +S S S      S           S + T++    S    +   S+
Sbjct: 587 FD----HIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHST 642

Query: 548 RSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIR----------DRRRS 597
           R  SP+  +R   S  P+   + +R     R  K E+ +   K+R          DRRR 
Sbjct: 643 RQKSPEIHRRIDIS--PSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRK 700

Query: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHK 657
            R+    + + +R  S  R++ ++  +D +  ++ +  S+ +R+ D  R + S  S    
Sbjct: 701 ERSKERGDSKGSRESSGSRKQEKT-PKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSP 759

Query: 658 GEAKEQERKKERSRSIDKDRKKKD 681
              +E+E KKER        + K+
Sbjct: 760 SSREEKESKKEREEEFKTHHEMKE 783



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 94/472 (19%), Positives = 170/472 (36%), Gaps = 51/472 (10%)

Query: 244 EREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAA 303
           E E  K   K  ++  R     +E+K  +  E G     P  +K   D+ +E+ +N E  
Sbjct: 430 EEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTK---DKHKEEDKNSERI 486

Query: 304 SSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHR 363
           +  K T+SP  V  E+  D           +    K    E     +   I  +A D+HR
Sbjct: 487 TVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFRE----ESPLRIKMIASDSHR 542

Query: 364 KATK---APAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG--------SESSDTDD 412
              K   AP   L  S+  ASLT    L        + E+  R           S  T +
Sbjct: 543 PEVKLKMAPVP-LDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSE 601

Query: 413 EELRHRI----RQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSL 468
             ++H +      K++ F   +     L+++    +K   E  T++ +  IH+       
Sbjct: 602 SFIQHIVSLVHHVKEQYF---KSAAMTLNERFTSYQKATEEHSTRQKSPEIHRR------ 652

Query: 469 LEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTS 528
                     ++    T  + T +   ++  KE+ ++G  +    S+       R     
Sbjct: 653 ----------IDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKER 702

Query: 529 STVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRAR 588
           S         S GS  +S      K  K +   +S    ++  R + +SR     ++ + 
Sbjct: 703 S----KERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSS 758

Query: 589 VKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSR----DRRTNRASRSRSRDRRKIDD 644
              R+ + S +   E  +  +           SR R    D R +       R R +   
Sbjct: 759 PSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFHDDRDDGVDYWAKRGRGRGTF 818

Query: 645 QRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQK 696
           QRG    N  K  G + +    K +   I +D ++  +  E ++D+RKE+++
Sbjct: 819 QRGRGRFN-FKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE 869



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 52/207 (25%), Positives = 81/207 (39%), Gaps = 21/207 (10%)

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDR------RTNRASRSRSRDRRKIDDQRGNLSGN 652
           R++      R++S S+   RSRSRS  R      R+   SRSRSRDR    D R +   N
Sbjct: 3   RSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNN 62

Query: 653 -------SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705
                   ++ +G    Q       R      +     R     +R   + R  K    S
Sbjct: 63  RGMRRPYGYRGRGRGYYQGGGGRYHRG---GYRPVWNRRHSRSPRRGRSRSRSPKRRSVS 119

Query: 706 SQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESP 765
           SQ  R + +R    + S   S S     +     SK+   + S++     + G    ESP
Sbjct: 120 SQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR---RGSQEKQTKKAEGEPQEESP 176

Query: 766 GSSKEKKAKKP--KHSRSRSVEKSQRS 790
             SK ++  K   +H  S S+++  +S
Sbjct: 177 LKSKSQEEPKDTFEHDPSESIDEFNKS 203



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/179 (25%), Positives = 73/179 (40%), Gaps = 28/179 (15%)

Query: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711
           NS  H   +K + +   RSRS    RKK+ + R R   + + + +   +D++   +++R 
Sbjct: 5   NSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNNRG 64

Query: 712 KRKRESER------------TFSRSGSISVKIIRHD-------SRQDS-KKSTTKDSKKH 751
            R+    R             + R G   V   RH        SR  S K+ +    +  
Sbjct: 65  MRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSR 124

Query: 752 SGSDSSGRSSSESPGSSKEKK----AKKPKHSRSRSVEKSQRSGKKASRKH---KSKSR 803
           S S  S R SS SP SS  +     +K P   R  S EK  +  +   ++    KSKS+
Sbjct: 125 SRSRRSYR-SSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQ 182



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 77/355 (21%), Positives = 129/355 (36%), Gaps = 57/355 (16%)

Query: 470 EAREADGDVVNEKKRTPNETTSVLEPKK--EHKEKEKQGRSRSGSSSSGSSSSNSRTSST 527
           + ++A+G+   E   +P ++ S  EPK   EH   E        S++SG           
Sbjct: 163 QTKKAEGEPQEE---SPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDN 219

Query: 528 SSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRA 587
           S     S    ++  S++SS S +P     HS   +P+   + S S  +S          
Sbjct: 220 SPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPS---QHSHSIQHSPE-------- 268

Query: 588 RVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKI----D 643
               R    S  N   R      SP       RS ++      A R  SR R        
Sbjct: 269 ----RSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGG 324

Query: 644 DQRGNLSGNSHKH------------KGEAKEQERKKERSRSIDKDRKKKDKEREREQDKR 691
           DQ    +G   K             +G  +++E  KE+    +K R + + E +   D  
Sbjct: 325 DQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGS--EKGRAEGEWEDQEALDYF 382

Query: 692 KEKQKREEKDFKFSSQDDRLKRKRESERTFSRS-----GSISVKIIRHDSRQDSKKSTTK 746
            +K+  ++K F  S  DD    + E  R F +S     G         ++ ++  K  +K
Sbjct: 383 SDKESGKQK-FNDSEGDDT--EETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSK 439

Query: 747 DSKKHSGSDSSGRSSS-----------ESPGSSKEKKAKKPKHSRSRSVEKSQRS 790
            S K +      R              E P ++K+K  ++ K+S   +V+K  +S
Sbjct: 440 VSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQS 494



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 89/422 (21%), Positives = 146/422 (34%), Gaps = 76/422 (18%)

Query: 391 YGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKE-KEQQLLHDKQMEEEKQQTE 449
           Y S  S    S R S          R   ++KQ      E +E+  L  K  EE K   E
Sbjct: 131 YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFE 190

Query: 450 RVTKE-MNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRS 508
               E ++EF      S  +     A     +   R+P+  + +  P  +          
Sbjct: 191 HDPSESIDEFNKSSATSGDIWPGLSA----YDNSPRSPHSPSPIATPPSQSSSCSDAPML 246

Query: 509 RSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKA 568
            +  S+  + S +S  S   S   S S S  +GSSR S   +SP       RS + TI  
Sbjct: 247 STVHSAKNTPSQHSH-SIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAP 305

Query: 569 RR-----SRSRS----------------YSRRIKIESNRA----RVKIRDRRRSNRNSIE 603
           +      SR RS                + +R   E +R     R   RD+  S     E
Sbjct: 306 QNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSE 365

Query: 604 RERRR----------------------NRSPSRERRRSRSRSRDRRTNRASRSRS---RD 638
           + R                        N S   +   +    + R++  A + +S     
Sbjct: 366 KGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATAS 425

Query: 639 RRKIDDQ------RGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDK-- 690
            R  +++      + +L GN        ++  + KE    +++    KDK +E +++   
Sbjct: 426 HRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSER 485

Query: 691 ---RKEKQKREE------KD-FKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDS 740
              +KE Q  E+      KD F +S    +    RE + TF     + +K+I  DS +  
Sbjct: 486 ITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDARE-KSTFREESPLRIKMIASDSHRPE 544

Query: 741 KK 742
            K
Sbjct: 545 VK 546



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 139/740 (18%), Positives = 247/740 (33%), Gaps = 125/740 (16%)

Query: 165 DYQHGAAFGPPQG--GFHPPYWQPGPP----GPPAPPQNRRERPSSFRDRQRSPIALPVK 218
           DY++      P G  G    Y+Q G      G   P  NRR   S  R R RS       
Sbjct: 58  DYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRS------- 110

Query: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKK---EKKATEDAE 275
           + P +     +R+     R    +  R  +    +      +S +SK+   ++K T+ AE
Sbjct: 111 RSPKRRSVSSQRSRSRSRRS--YRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAE 168

Query: 276 GGDGPRLPQRSK--------FDSDEEEE-DTENVEAASSGKVTRSPSPV---PQEEHSDP 323
           G      P +SK        F+ D  E  D  N  +A+SG +    S     P+  HS  
Sbjct: 169 GEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPS 228

Query: 324 EMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDA---------------------- 361
            +     +        ML T      T  +  +  + +                      
Sbjct: 229 PIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNS 288

Query: 362 ---HRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHR 418
              H  + ++PAK +A  +A    +   G   +     + E +  G       DEE R  
Sbjct: 289 PIHHIPSRRSPAKTIAPQNAPRDESR--GRSSFYPDGGDQETAKTGKFLKRFTDEESRVF 346

Query: 419 IRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV 478
           +  +        ++++   +K  E+ + + E   +E  ++   +++        E D   
Sbjct: 347 LLDRGNT-----RDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTE 401

Query: 479 VNEKKRTPNETTSVLEPKK----EHKEKEKQG-RSRSGSSSSGSSSSNSRTSSTSSTVSS 533
             E  R   ++    + K      H+  E++G + +S  S  G+  S+      +  +  
Sbjct: 402 ETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKE 461

Query: 534 SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRD 593
           + Y     S+      +  K K+    S   T+K    +      ++K E  +       
Sbjct: 462 TGYVVERPST------TKDKHKEEDKNSERITVK----KETQSPEQVKSEKLKDLFDYSP 511

Query: 594 RRRSNRNSIERERRRNRSPSR-----------------------ERRRSRSRSRDR---R 627
               N ++ E+   R  SP R                       +  R  S ++DR    
Sbjct: 512 PLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLAS 571

Query: 628 TNRASRSRSRDRRKIDD-----QRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDK 682
           T   S  + ++ R I D     Q    +  S      +     K++  +S      ++  
Sbjct: 572 TLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFT 631

Query: 683 EREREQDKRKEKQKREEKDFKFSSQDDRLKRKRE---SERTFSRSGSISVKIIR------ 733
             ++  ++   +QK  E   +       L++       ER F        K +R      
Sbjct: 632 SYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADL 691

Query: 734 -HDSRQDSK-KSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKK--PKHSR----SRSVE 785
            HD  +  K +S  +   K S   S  R   ++P   KE K+ K   KH R    SRS  
Sbjct: 692 RHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSS 751

Query: 786 KSQRSGKKASRKHKSKSRSR 805
            S      +SR+ K   + R
Sbjct: 752 SSASPSSPSSREEKESKKER 771



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 16/48 (33%), Positives = 27/48 (56%)

Query: 758 GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
           GRS+S S  S  + +++    SRSRS  + +R   ++    +S+SR R
Sbjct: 2   GRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDR 49


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 90/419 (21%), Positives = 154/419 (36%), Gaps = 41/419 (9%)

Query: 405 SESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKE-- 462
           ++  +  DEE + R +  + A     +E     +   +E      +  KE  E I +   
Sbjct: 190 NDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFP 249

Query: 463 -----------QNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG 511
                      +  ++ +E  E   D+++ +     +T   LE +K  KEKE+Q   +  
Sbjct: 250 VAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER 309

Query: 512 SSSSGSSS-SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARR 570
                       R                    R   R     R K   R R       R
Sbjct: 310 RERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDR 369

Query: 571 SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNR 630
            R RS  R    + +R+R K RDR R      ERER R R   RER R R R R+R    
Sbjct: 370 DRERSSDRNK--DRSRSREKSRDRERERERERERERERERERERERERERERERER---E 424

Query: 631 ASRSRSRDRRKIDDQRGNLSGNSHK-HKGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
             + + RDR + ++          K  + EA  QER K       K  ++ +KE ERE++
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEE 484

Query: 690 KRKE--KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKD 747
           +R+E  K+ +  K+F     DDR       +  + R  ++  ++   +   ++ +   K 
Sbjct: 485 RRREMAKEAKRLKEFLEDYDDDR------DDPKYYRGSALQKRLRDREKEMEADERDRKR 538

Query: 748 SKK-------------HSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKK 793
            K+             H   D+  +   +     ++ + K+   S     EK ++  K+
Sbjct: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 55/219 (25%), Positives = 99/219 (45%), Gaps = 22/219 (10%)

Query: 590 KIRDRRRS---NRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQR 646
           K RD  +     +   E+ER+      RER R R R R+RR     R R R+R K     
Sbjct: 283 KFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK----- 337

Query: 647 GNLSGNSHKHKGEAKEQERKKERSRSIDKDR---KKKDKEREREQDKRKEKQKREEKDFK 703
                   K +   +E++R ++R++  D+DR   + +D++RER  D+ K++ +  EK   
Sbjct: 338 -------EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS-- 388

Query: 704 FSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSE 763
              ++   +R+RE ER   R      +  R   R+  ++   K  ++    D+  R   E
Sbjct: 389 -RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447

Query: 764 SPGSSKEKK-AKKPKHSRSRSVEKSQRSGKKASRKHKSK 801
                KE    ++ K+   R  +K++   K+A R+ + +
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 76/400 (19%), Positives = 159/400 (39%), Gaps = 28/400 (7%)

Query: 394 GDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTK 453
           G  E ER +   E  + + E  R R R+++E    +E+E++   +++ E E+ +    TK
Sbjct: 296 GKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTK 355

Query: 454 EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQ-GRSRSGS 512
           E +    +E++       RE   D   ++ R+  ++      ++  +E+E++  R R   
Sbjct: 356 ERDRDRDRERDR---DRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERE 412

Query: 513 SSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSR 572
                     R                +   R   R    K      R ++  I+ R+ +
Sbjct: 413 REREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERK-K 471

Query: 573 SRSYSRRIKIESNRARVKIRDRRRSNR--NSIERERRRNRSPSRERRRSRSRSRDRRTNR 630
           +R Y +  + E  R R   ++ +R        + +R   +       + R R R++    
Sbjct: 472 TREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEA 531

Query: 631 ASRSRSRDRRKIDDQRGNLSGNSHKH-KGEAKEQERKKERSRSIDKDRKKKDKEREREQD 689
             R R R++ ++++ R  L    H     E +  E++ ER R   + + K++ E E E++
Sbjct: 532 DERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRR---QPQIKQEPESEEEEE 588

Query: 690 KRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVK-----------------II 732
           +++EK+++ E+  +   + ++    + + R  S + S+S                   II
Sbjct: 589 EKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIII 648

Query: 733 RHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKK 772
            H++  D ++      K          +S   P S K KK
Sbjct: 649 PHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKK 688



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 59/275 (21%), Positives = 125/275 (45%), Gaps = 33/275 (12%)

Query: 538 SSSGSSRTSSRSSSPKRK-KRHSRSRSPTIK-ARRSRSRSYSRRIKIESNRARVKIRDRR 595
           +S+G++R  + ++  +      ++ R   IK A     R YS  +   S  +    R ++
Sbjct: 178 ASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKK 237

Query: 596 RSNRNSIERERRRNRSP-------SRERRRSRSRSRDRRTNRASRSRSRDR---RKIDDQ 645
           +  +  I R  R   +P       ++E   +     D+R +  SR  S+ R   +K++++
Sbjct: 238 KEKKEDIFR--RFPVAPLIPYPLITKEDINAIEMEEDKR-DLISREISKFRDTHKKLEEE 294

Query: 646 RGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705
           +G       K + E +++ R++ER R  +++R+++++ERERE+++ +EK+K  E++ +  
Sbjct: 295 KGK----KEKERQEIEKERRERERER--ERERERREREREREREREREKEKERERERERD 348

Query: 706 SQDDRLK---RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762
              DR K   R R+ ER   R           +   D  K  ++  +K    +       
Sbjct: 349 RDRDRTKERDRDRDRERDRDRD---------RERSSDRNKDRSRSREKSRDRERERERER 399

Query: 763 ESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
           E     + ++ ++ +  R R  E+ +   KK  R+
Sbjct: 400 EREREREREREREREREREREREREREKDKKRDRE 434



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 57/263 (21%), Positives = 105/263 (39%), Gaps = 28/263 (10%)

Query: 539 SSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSN 598
           SS  +  S  S S  RKK+  +      +   +    Y    K + N   ++  D+R   
Sbjct: 219 SSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEME-EDKRDLI 277

Query: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKG 658
              I + R  ++    E+ +     ++    R  R R R+R +             + + 
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER-------------ERRE 324

Query: 659 EAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESE 718
             +E+ER++ER        K+K++ERERE+D+ +++ K  ++D       DR  R+R S+
Sbjct: 325 RERERERERER-------EKEKERERERERDRDRDRTKERDRDRDRERDRDR-DRERSSD 376

Query: 719 RTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKH 778
           R   RS S      R  SR   ++   +  ++        R         +E++ +K K 
Sbjct: 377 RNKDRSRS------REKSRDREREREREREREREREREREREREREREREREREREKDKK 430

Query: 779 SRSRSVEKSQRSGKKASRKHKSK 801
                 E+     +K  RK + K
Sbjct: 431 RDREEDEEDAYERRKLERKLREK 453



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/168 (21%), Positives = 80/168 (47%), Gaps = 10/168 (5%)

Query: 643 DDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDF 702
           +D+R  +S    K +   K+ E +K +     ++ +K+ +ERERE+++ +E+++RE +  
Sbjct: 271 EDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERE 330

Query: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762
           +   ++   +R+RE ER   R      +    D  +D ++   +D ++ S  +     S 
Sbjct: 331 REREREKEKERERERERDRDRD-----RTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385

Query: 763 ESPGSSKEKKAKKPKHSRSRSVEKS-----QRSGKKASRKHKSKSRSR 805
           E     + ++ ++ +  R R  E+      +R  ++   + K K R R
Sbjct: 386 EKSRDREREREREREREREREREREREREREREREREREREKDKKRDR 433



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 50/275 (18%), Positives = 107/275 (38%), Gaps = 54/275 (19%)

Query: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAE-----GGDGPRLPQRSKFDSDEEEE 295
           E+ ERE++++ E+ER E++R +  ++E++  ++ E       D  R  +R + D D E +
Sbjct: 308 ERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR-DRDRERD 366

Query: 296 DTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIY 355
              + E +S     RS S     +       E E+E +                      
Sbjct: 367 RDRDRERSSDRNKDRSRSREKSRDRERERERERERERER--------------------- 405

Query: 356 YVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDT-DDEE 414
              ++  R+  +   ++  +                     +D++ DR  +  D  +  +
Sbjct: 406 --ERERERERERERERERERER------------------EKDKKRDREEDEEDAYERRK 445

Query: 415 LRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREA 474
           L  ++R+K+ A+  + K  ++   K+  E +++ ER  +   E   + +     LE  + 
Sbjct: 446 LERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDD 505

Query: 475 DGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSR 509
           D D     +       S L+ +   +EKE +   R
Sbjct: 506 DRDDPKYYR------GSALQKRLRDREKEMEADER 534



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 36/149 (24%), Positives = 63/149 (42%), Gaps = 6/149 (4%)

Query: 662 EQERKKERSRSIDKDRKKKDKEREREQDKRKEKQ----KREEKDFKFSSQDDRLKRKRES 717
           E++++   SR I K R    K  E +  K KE+Q    +R E++ +   + +R +R+RE 
Sbjct: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329

Query: 718 ERTFSRSGSISVKIIR-HDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKP 776
           ER   R      +  R  D  +D  K   +D  +    D     SS+        + K  
Sbjct: 330 EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSR 389

Query: 777 KHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
              R R  E+ +R  ++   + + + R R
Sbjct: 390 DRERERERER-ERERERERERERERERER 417



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 56/295 (18%), Positives = 113/295 (38%), Gaps = 17/295 (5%)

Query: 237 REGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEED 296
           RE   + ERE++++ E+ER  ++  +  KK  +  ++ +  +  +L ++ +      +E 
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460

Query: 297 TENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYY 356
            +N E     K         +EE    EM +E K  +  L       E   D  D+  YY
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL-------EDYDDDRDDPKYY 513

Query: 357 VA-------KDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSD 409
                    +D  ++       +  +   L  +       G+   D+E +R ++  E+  
Sbjct: 514 RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ--EAER 571

Query: 410 TDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQ-NSLSL 468
               +++     ++E   ++EKE++     + EEE +Q   +   +         +S S 
Sbjct: 572 RRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASG 631

Query: 469 LEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSR 523
                  GD        P+E +   +  +EH+ K         S+S G  +S  R
Sbjct: 632 NATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKR 686



 Score = 37.4 bits (85), Expect = 0.056
 Identities = 68/359 (18%), Positives = 130/359 (36%), Gaps = 32/359 (8%)

Query: 200 ERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQ 259
           E     ++++R  I    ++   + +  + R      RE   + E+EK+++ E+ER   +
Sbjct: 292 EEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDR 351

Query: 260 RSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEE 319
                +   +  E     D  R   R+K D     E + + E     +  R      + E
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNK-DRSRSREKSRDRERERERERERERERERERE 410

Query: 320 HSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSAL 379
                  E E+E +     K    E      DEE  Y  +   RK  +   K+ A    L
Sbjct: 411 REREREREREREREREKDKKRDREE------DEEDAYERRKLERKLRE---KEAAYQERL 461

Query: 380 ASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQE-----AFWRKEKEQQ 434
            +   +         + E ER +        + + L+  +    +      ++R    Q+
Sbjct: 462 KNWE-IRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520

Query: 435 LLHD--KQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV----VNEKKRTPNE 488
            L D  K+ME +++  +R  +E+ E   +      LL     D D     + ++     +
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQR------LLAEGHPDPDAELQRMEQEAERRRQ 574

Query: 489 TTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTV----SSSSYSSSSGSS 543
                EP+ E +E+EKQ +               +      T+    S+ S SS+SG++
Sbjct: 575 PQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNA 633


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.122    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,953,323
Number of Sequences: 37866
Number of extensions: 2258395
Number of successful extensions: 69444
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1016
Number of HSP's successfully gapped in prelim test: 1664
Number of HSP's that attempted gapping in prelim test: 18672
Number of HSP's gapped (non-prelim): 22707
length of query: 805
length of database: 18,247,518
effective HSP length: 110
effective length of query: 695
effective length of database: 14,082,258
effective search space: 9787169310
effective search space used: 9787169310
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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