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Search of human proteins with 154090997
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154090997 coiled-coil domain containing 13 [Homo sapiens]
(715 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154090997 coiled-coil domain containing 13 [Homo sapiens] 1364 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 86 2e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 85 3e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 84 3e-16
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 79 1e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 79 2e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 79 2e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 79 2e-14
gi|21735548 centrosomal protein 2 [Homo sapiens] 77 7e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 77 7e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 77 7e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 76 9e-14
gi|16262452 cingulin [Homo sapiens] 75 2e-13
gi|55770834 centromere protein F [Homo sapiens] 75 3e-13
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 74 4e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 6e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 6e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 6e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 6e-13
gi|4506751 restin isoform a [Homo sapiens] 73 1e-12
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 73 1e-12
gi|38044112 restin isoform b [Homo sapiens] 72 1e-12
gi|71061468 centromere protein E [Homo sapiens] 72 1e-12
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 71 3e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 70 5e-12
gi|42794779 myosin 18A isoform b [Homo sapiens] 69 1e-11
gi|58530840 desmoplakin isoform I [Homo sapiens] 69 2e-11
gi|45439327 periplakin [Homo sapiens] 69 2e-11
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 69 2e-11
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 69 2e-11
>gi|154090997 coiled-coil domain containing 13 [Homo sapiens]
Length = 715
Score = 1364 bits (3530), Expect = 0.0
Identities = 715/715 (100%), Positives = 715/715 (100%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL
Sbjct: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF
Sbjct: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS
Sbjct: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK 240
AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK
Sbjct: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK 240
Query: 241 VLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSV 300
VLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSV
Sbjct: 241 VLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSV 300
Query: 301 YPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLS 360
YPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLS
Sbjct: 301 YPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLS 360
Query: 361 SEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLN 420
SEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLN
Sbjct: 361 SEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLN 420
Query: 421 SEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQF 480
SEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQF
Sbjct: 421 SEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQF 480
Query: 481 LEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQK 540
LEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQK
Sbjct: 481 LEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQK 540
Query: 541 GWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQ 600
GWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQ
Sbjct: 541 GWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQ 600
Query: 601 HLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEEL 660
HLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEEL
Sbjct: 601 HLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEEL 660
Query: 661 TTRLAIQVEENEMLKAALGSALRGKEEDFRMYHEILGQVKSVFLQALRQQKTGKQ 715
TTRLAIQVEENEMLKAALGSALRGKEEDFRMYHEILGQVKSVFLQALRQQKTGKQ
Sbjct: 661 TTRLAIQVEENEMLKAALGSALRGKEEDFRMYHEILGQVKSVFLQALRQQKTGKQ 715
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 85.5 bits (210), Expect = 2e-16
Identities = 139/664 (20%), Positives = 271/664 (40%), Gaps = 86/664 (12%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKRE---KELSLKSRADDQEEPLEVS-DGLSLL 60
E +N L+ +M+ Q + K++E ++E K L L + + E LEVS GL +
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI- 763
Query: 61 HAGEPNSKNSFEKRVLED---EIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEE 117
+N ++ LE+ +I+ L +EL++ EN L K L+E K L++ +E
Sbjct: 764 -------ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 118 DRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALT 177
++ T+ + D +L K+N+ L ++E T +++ +I LE+E +T
Sbjct: 817 NKSLEQETSQLEKDKK-----QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 178 RLSAKGATDAGAKP---PRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQE 234
+ + K ++ RA ++ + L++ LV+ LK + N ++ + E
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 235 LRMA----QKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQS 290
L +++L E D + +LL S + + + + K+ LE +L ++ + +
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESK-LESTLKKSLEIKEEKIAALEARLEESTNYN 990
Query: 291 AGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFE 350
+ +V + L ++ ++S E K E REL ++K +
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED-NKWERESQETTRELLKVKDRLI 1049
Query: 351 GMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRV 410
+ N L +E + LK+Q+ L + + I AL Q LQE +L Q K +V
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL---------NVHYLRN 461
L+ Q S ++ L+ Q ++ E E+ +++ E ++ L + L
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE-DLKSLYDSLIKDHEKLELLHE 1168
Query: 462 KGVGEGSS------------------GREVSPAYTQFLEDPGLTKS-------------- 489
+ E S R++ Y Q L+ G +
Sbjct: 1169 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1228
Query: 490 -----PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSP--EQKGW 542
A ++ G + L HT + L + H+ ++ EQ
Sbjct: 1229 ENKNHETVAAEYKKLCGEN---DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 543 QAQVSEIKALWQAAEVERDRLT---EFVTVLQKRVEESNSKLLESERKLQEERHRTVVLE 599
+A+ S++K +Q ++ +L E ++ L+ +EE N LL+ + L + +LE
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR--TLLE 1343
Query: 600 QHLE 603
Q++E
Sbjct: 1344 QNME 1347
Score = 73.6 bits (179), Expect = 6e-13
Identities = 103/486 (21%), Positives = 207/486 (42%), Gaps = 56/486 (11%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E+ + Q K +++ Q ++ ++S ++R D E+ ++ S+
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE-SIKETSS 601
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
SK FEKR ++ E+EH + + + L+ L KE + L+KKI +
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL----LQKKITNLK----- 652
Query: 125 TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRV---KQLTNRIQELERE-----LQTAL 176
+ KI L ++N L E+ K + K LT +++ LE+E +
Sbjct: 653 -------ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 177 TRLSAKGATDAGAKPPRAQMGDRAL-LETPEVKALQDRLVATNLKMSDLRNQIQSVKQEL 235
R + + A K + Q+ ++ L E ++K + L A+ K L Q + E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 236 RMAQKVLAREVGE----DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSA 291
+ QK L + + +Q L T + +++ + ++++LEK+ +++
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 292 GTASDELSVYPDPRKLSAQ--------EKNLLRIRSLERE-----KQEGLEKLASER-DV 337
D+ + + ++L Q E+N ++I +LE+E K+ G+ K + R
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 338 LQRELEELKKKF-----EGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLK 392
L++E +EL K+ + R L+S ++KT QM +EK H+ E I ++L
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELEKIGLNKERLL 943
Query: 393 QLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIG 452
++ S + + ++ + L+ L + +A L+A + E +QL E+
Sbjct: 944 HDEQ-----STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998
Query: 453 QLNVHY 458
+ +Y
Sbjct: 999 TVKKNY 1004
Score = 72.0 bits (175), Expect = 2e-12
Identities = 133/640 (20%), Positives = 263/640 (41%), Gaps = 109/640 (17%)
Query: 24 KRLQKQMEKKREKELSLKSRADDQEEPLE--VSDGLSLLHAGEPNSKNSFEKRVLEDEIE 81
+RL++++E+K E+ L K + E L+ + ++LL ++ R+ DE++
Sbjct: 261 RRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL-------SDARSARMYRDELD 313
Query: 82 HLRNELRETVDENGRLYKLLKERDFEIKHLKKKIE---EDRFAFTGTAGVAGDVV----- 133
LR E VD+ KER +I+ K ++E ED T + D +
Sbjct: 314 ALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 134 -ATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALT--------------R 178
+ K+ EL K+N L A+ + +I+EL E T
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 179 LSAKGATDAGAKPPRAQMG-----------------DRALLETPE--------------- 206
L T ++ P+ +G +++L +T E
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 207 VKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRA 266
+ ++ + K+ L N+I KQ L+ Q + + E +++ + +
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET--LRENSE 550
Query: 267 QQILVLQSKVQELEKQLGQARSQSAGTASDEL------------SVYPDPRKLSAQEKNL 314
+QI +L+ + + L + + R +S +A + S+ KLS E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 315 LRI-RSLE--REKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 371
+I + LE +EK E E+L +E L++E E L+KK + K+ +++ L+ +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL----KITCEKIEALEQENS 666
Query: 372 TLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSL-V 430
L + R + +D+ + QL+ SL++E +++ + +L+ + N E+ + S+ +
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLE------SLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 431 AQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSP 490
AQLQ E E++ QL+ + L + + + + G ++ E+ L K+
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI--------ENQRLQKTL 772
Query: 491 ASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSD-SPEQKGWQAQVSEI 549
++ + +L S L +E+ + +L +S R E K + + S++
Sbjct: 773 ENSNKKIQQLES-----ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKL--LESERK 587
+ + E E RL + + +EE+N K+ LE E K
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Score = 36.6 bits (83), Expect = 0.083
Identities = 71/367 (19%), Positives = 140/367 (38%), Gaps = 61/367 (16%)
Query: 251 NVQQLLSSPGTWRGRAQQILVLQ-----SKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+ Q SPG R ++Q L ++ +K++ L ++L + Q + + + +
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 306 KLSAQEKNLL---RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + NLL R + R++ + L + A D L+ E+ K++
Sbjct: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL------------- 336
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
HD E A +++LK+ ++L E +L+
Sbjct: 337 ----------------HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380
Query: 423 AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQ-LNVHYLRNKGVGEG-SSGREVSPAYTQF 480
+ + L A+L M ER+ +++E + + + + + + + E G E+ Q
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE----QI 436
Query: 481 LEDPGLTKSP-ASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
L+++P S G V L SSR L++ + SL DS E
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSR--------LLKLEMENQSLTKTVEELRTTVDSVE- 487
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLE 599
S+I + E E RL++ V +L+ + + L + ++ LE
Sbjct: 488 ----GNASKILKM----EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 600 QHLEKIR 606
+ +E +R
Sbjct: 540 KTIETLR 546
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 84.7 bits (208), Expect = 3e-16
Identities = 158/713 (22%), Positives = 289/713 (40%), Gaps = 90/713 (12%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
+E L+ + K MQ+ + L++Q+E++ L+ E L+ + ++
Sbjct: 927 EEERCQHLQAEKKKMQQ-NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII-LE 984
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ N K + EK++LED I L E +++ L KL + + I L++++ +
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREE---- 1040
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL-------ERELQTAL 176
+ EL K R L +S ++ +L +I EL E ELQ AL
Sbjct: 1041 -----------KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR 236
R+ + A A ++ + ++++ + + DL +++++K EL
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 237 ------MAQKVLAREVGEDINV--QQLLSSPGTWRGRAQQILVLQSK-VQELEKQLGQAR 287
AQ+ L + +++N+ + L T + Q++ S+ V+EL +QL Q +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK 347
A + ++ + +L+ + K LL+ + K++ +E +L+EL+
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE----------AQLQELQV 1259
Query: 348 KF-EGMRSRNKLLSSEMK---TLKSQMGTLVEKGRHDDEL---IDALMDQLKQLQEILGS 400
KF EG R R +L K L + G L + +L AL QL+ QE+L
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL-- 1317
Query: 401 LSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
+E + ++S L +L NS QL+ E EAK LE +I L+
Sbjct: 1318 --QEENRQKLS---LSTKLKQVEDEKNSFREQLE---EEEEAK-HNLEKQIATLHAQVAD 1368
Query: 461 NKGVGEGSSG-----REVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVE 515
K E S G EV + LE GL++ +L ++ T ++
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLE--GLSQRHEEKVAAYDKLEKTK-------TRLQ 1419
Query: 516 SALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVE 575
L + H+ + +QK + ++E K + ERDR +
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR-------AEAEAR 1472
Query: 576 ESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
E +K L R L+E + LE+ ++ R E +S+ ++ L S
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 636 TGSEKKDPSFAQLSDVPVESQ-MEELTTRLAIQVEENEMLKAALGSALRGKEE 687
E K QL ++ E Q E+ RL + + + +KA L+G++E
Sbjct: 1533 QVEEMK----TQLEELEDELQATEDAKLRLEVNL---QAMKAQFERDLQGRDE 1578
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/706 (19%), Positives = 280/706 (39%), Gaps = 105/706 (14%)
Query: 19 QEMQHKRLQKQMEKKREKELSLKSRADDQE--------EPLEVSDGLSL-----LHAGEP 65
QE + ++++ K REK+L+ ++R + E E L++ + L A E
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 66 NSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA--FT 123
++ + +K+ LE+ L + E + L K+ I+ L++++EE+ A
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 124 GTAGVAGDVVATKIVE----LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRL 179
V + K+ E L +N L E + + R+ + T + E E E +L +L
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE-EEEKSKSLAKL 1021
Query: 180 SAKG---ATDAGAKPPRAQMGDRALLET-----PEVKALQDRLVATNLKMSDLRNQIQSV 231
K TD + R + + L +T + L D++ ++++L+ Q+
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 232 KQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSA 291
++EL Q LAR E L ++I L+S++ EL++ L R+
Sbjct: 1082 EEEL---QAALARVEEEAAQKNMAL----------KKIRELESQISELQEDLESERASR- 1127
Query: 292 GTASDELSVYPDPRKLSAQEKNL-LRIRSLEREKQEGLEKLASERDVLQRELEELKKKFE 350
K Q+++L + +L+ E ++ L+ A+++++ + +E
Sbjct: 1128 -------------NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE------ 1168
Query: 351 GMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRV 410
+ K L E KT ++Q+ + +K + ++ L +QL+Q + + +L ++
Sbjct: 1169 -VNILKKTLEEEAKTHEAQIQEMRQK---HSQAVEELAEQLEQTKRVKANLEKAKQTLE- 1223
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSG 470
N + +N + LQ + E K +++E ++ +L V + EG
Sbjct: 1224 ---------NERGELANEVKVLLQGK-GDSEHKRKKVEAQLQELQVKF------NEGERV 1267
Query: 471 REVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTS---LGHTLVESALTRPSLPSPH 527
R T+ + +TK + G L S S +S + +ES L
Sbjct: 1268 R------TELADK--VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 528 RTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
+ S S + K + + + + + E + L + + L +V + K+ +S
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGL---------PTSNNRHNPTGS 638
L+ L++ LE + + A+ +TKT L + R +
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 639 EKKDPSFAQL--SDVPVESQMEELTTRLAIQVEENEMLKAALGSAL 682
EKK F QL + + ++ E R + E E +L AL
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL 1485
Score = 60.8 bits (146), Expect = 4e-09
Identities = 101/472 (21%), Positives = 201/472 (42%), Gaps = 77/472 (16%)
Query: 2 AADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLH 61
A D+ + RLQ QE+ L ++ +R+ +L+ + ++ L +S +
Sbjct: 1407 AYDKLEKTKTRLQ----QELDD--LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 62 AGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA 121
A E + E R E + L L E +++ L +L K+ E++ L
Sbjct: 1461 A-EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS-------- 1511
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
+ D V + EL K R L + E KT++++L + +Q E A
Sbjct: 1512 -------SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE----------DA 1554
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK- 240
K + + +AQ + LQ R + K L Q++ ++ EL +K
Sbjct: 1555 KLRLEVNLQAMKAQFE----------RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Query: 241 ----VLAREVGE-DI-NVQQLLSSPGTWRGRA-QQILVLQSKVQELEKQLGQARSQSAGT 293
V AR+ E D+ +++ + S R A +Q+ LQ+++++ ++L R+
Sbjct: 1605 RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA----- 1659
Query: 294 ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDV---LQRELEELKKKFE 350
+ +E+ L+ ++N +++S+E E + E+LA+ Q+E +EL +
Sbjct: 1660 SREEI--------LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 351 GMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLK----QLQEILGSLSLQ-- 404
+ L E + L++++ L E+ + + + D+LK Q+ +I L+L+
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771
Query: 405 ----EEKTRVSQHHLDQQLNSEAQRSNSLV-AQLQAMVAEREAKVRQLEMEI 451
E R +++L + Q V ++ +A + EAK+ QLE ++
Sbjct: 1772 HAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/420 (20%), Positives = 171/420 (40%), Gaps = 46/420 (10%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +AM+ + LQ + E+ EK+ L + + E LE
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE-------- 1599
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
+ S ++ LE +++ L + K L++ ++K +++++ R
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
+ A + K ++ + + + E A R K+ + Q+ EL + S
Sbjct: 1660 SREEILAQAKE--NEKKLKSMEAEMIQLQEELAAAERAKR---QAQQERDELADEIANSS 1714
Query: 181 AKGATDAGAKPPR----AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QSVKQ 233
KGA K AQ+ + E + + DRL NL++ + + +S Q
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQ-QILVLQSKVQELEKQLGQARSQSAG 292
+ A++ L R+ +++ V+ L GT + + + I L++K+ +LE+QL +
Sbjct: 1775 KNENARQQLERQ-NKELKVK-LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 293 TAS----------DELSVYPDPRKLSAQ-----EKNLLRIRSLER---EKQEGLEKLASE 334
D L D R+ + Q +K R++ L+R E +E ++ +
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANAS 1892
Query: 335 RDVLQRELEELKKKFEGMRS-----RNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMD 389
R LQRELE+ + + M +NKL ++ + + G DE +D D
Sbjct: 1893 RRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKAD 1952
Score = 47.4 bits (111), Expect = 5e-05
Identities = 92/417 (22%), Positives = 162/417 (38%), Gaps = 54/417 (12%)
Query: 306 KLSAQEKNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + K LL++ E E K+E L K+ ++ + L E+ E ++S+ L +E
Sbjct: 829 RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEM----ETLQSQ---LMAE 881
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLD------ 416
L+ Q+ E +EL L + ++L+EI L + E+ HL
Sbjct: 882 KLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKM 941
Query: 417 ----QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME---IGQLNVHYLRNKGVGEGSS 469
Q+L + + S +LQ EAK+++LE E + N + K + E
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED-- 999
Query: 470 GREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRT 529
++ T E+ +KS A + +T L L R L R
Sbjct: 1000 --RIAEFTTNLTEEEEKSKSLAKLKNK-----HEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 530 SPRFSD--SPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQ---------KRVEESN 578
S S + QAQ++E+K Q A+ E + V + K++ E
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELK--MQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110
Query: 579 SKLLESERKLQEER-------HRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNN 631
S++ E + L+ ER + L + LE ++ E S A ++ N
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170
Query: 632 RHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEED 688
T E+ AQ+ + + + + LA Q+E+ + +KA L A + E +
Sbjct: 1171 ILKKTLEEEAKTHEAQIQE--MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 84.3 bits (207), Expect = 3e-16
Identities = 139/664 (20%), Positives = 271/664 (40%), Gaps = 87/664 (13%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKRE---KELSLKSRADDQEEPLEVS-DGLSLL 60
E +N L+ +M+ Q + K++E ++E K L L + + E LEVS GL +
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI- 763
Query: 61 HAGEPNSKNSFEKRVLED---EIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEE 117
+N ++ LE+ +I+ L +EL++ EN L K L+E K L++ +E
Sbjct: 764 -------ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 118 DRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALT 177
++ T+ + D +L K+N+ L ++E T +++ +I LE+E +T
Sbjct: 817 NKSLEQETSQLEKDKK-----QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 178 RLSAKGATDAGAKP---PRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQE 234
+ + K ++ RA ++ + L++ LV+ LK + N ++ + E
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 235 LRMA----QKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQS 290
L +++L E D + L S + ++ +I + K+ LE +L ++ + +
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK--EEKIAALEARLEESTNYN 989
Query: 291 AGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFE 350
+ +V + L ++ ++S E K E REL ++K +
Sbjct: 990 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED-NKWERESQETTRELLKVKDRLI 1048
Query: 351 GMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRV 410
+ N L +E + LK+Q+ L + + I AL Q LQE +L Q K +V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL---------NVHYLRN 461
L+ Q S ++ L+ Q ++ E E+ +++ E ++ L + L
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE-DLKSLYDSLIKDHEKLELLHE 1167
Query: 462 KGVGEGSS------------------GREVSPAYTQFLEDPGLTKS-------------- 489
+ E S R++ Y Q L+ G +
Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1227
Query: 490 -----PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSP--EQKGW 542
A ++ G + L HT + L + H+ ++ EQ
Sbjct: 1228 ENKNHETVAAEYKKLCGEN---DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1284
Query: 543 QAQVSEIKALWQAAEVERDRLT---EFVTVLQKRVEESNSKLLESERKLQEERHRTVVLE 599
+A+ S++K +Q ++ +L E ++ L+ +EE N LL+ + L + +LE
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR--TLLE 1342
Query: 600 QHLE 603
Q++E
Sbjct: 1343 QNME 1346
Score = 72.0 bits (175), Expect = 2e-12
Identities = 133/640 (20%), Positives = 263/640 (41%), Gaps = 109/640 (17%)
Query: 24 KRLQKQMEKKREKELSLKSRADDQEEPLE--VSDGLSLLHAGEPNSKNSFEKRVLEDEIE 81
+RL++++E+K E+ L K + E L+ + ++LL ++ R+ DE++
Sbjct: 261 RRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL-------SDARSARMYRDELD 313
Query: 82 HLRNELRETVDENGRLYKLLKERDFEIKHLKKKIE---EDRFAFTGTAGVAGDVV----- 133
LR E VD+ KER +I+ K ++E ED T + D +
Sbjct: 314 ALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 134 -ATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALT--------------R 178
+ K+ EL K+N L A+ + +I+EL E T
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 179 LSAKGATDAGAKPPRAQMG-----------------DRALLETPE--------------- 206
L T ++ P+ +G +++L +T E
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 207 VKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRA 266
+ ++ + K+ L N+I KQ L+ Q + + E +++ + +
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET--LRENSE 550
Query: 267 QQILVLQSKVQELEKQLGQARSQSAGTASDEL------------SVYPDPRKLSAQEKNL 314
+QI +L+ + + L + + R +S +A + S+ KLS E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 315 LRI-RSLE--REKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 371
+I + LE +EK E E+L +E L++E E L+KK + K+ +++ L+ +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL----KITCEKIEALEQENS 666
Query: 372 TLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSL-V 430
L + R + +D+ + QL+ SL++E +++ + +L+ + N E+ + S+ +
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLE------SLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 431 AQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSP 490
AQLQ E E++ QL+ + L + + + + G ++ E+ L K+
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI--------ENQRLQKTL 772
Query: 491 ASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSD-SPEQKGWQAQVSEI 549
++ + +L S L +E+ + +L +S R E K + + S++
Sbjct: 773 ENSNKKIQQLES-----ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKL--LESERK 587
+ + E E RL + + +EE+N K+ LE E K
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Score = 72.0 bits (175), Expect = 2e-12
Identities = 103/486 (21%), Positives = 206/486 (42%), Gaps = 57/486 (11%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E+ + Q K +++ Q ++ ++S ++R D E+ ++ S+
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE-SIKETSS 601
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
SK FEKR ++ E+EH + + + L+ L KE + L+KKI +
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL----LQKKITNLK----- 652
Query: 125 TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRV---KQLTNRIQELERE-----LQTAL 176
+ KI L ++N L E+ K + K LT +++ LE+E +
Sbjct: 653 -------ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 177 TRLSAKGATDAGAKPPRAQMGDRAL-LETPEVKALQDRLVATNLKMSDLRNQIQSVKQEL 235
R + + A K + Q+ ++ L E ++K + L A+ K L Q + E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 236 RMAQKVLAREVGE----DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSA 291
+ QK L + + +Q L T + +++ + ++++LEK+ +++
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 292 GTASDELSVYPDPRKLSAQ--------EKNLLRIRSLERE-----KQEGLEKLASER-DV 337
D+ + + ++L Q E+N ++I +LE+E K+ G+ K + R
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 338 LQRELEELKKKF-----EGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLK 392
L++E +EL K+ + R L+S ++KT QM +EK H+ E I ++L
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELEKIGLNKERL- 942
Query: 393 QLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIG 452
L +++ ++ + L+ L + +A L+A + E +QL E+
Sbjct: 943 -----LHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 997
Query: 453 QLNVHY 458
+ +Y
Sbjct: 998 TVKKNY 1003
Score = 36.6 bits (83), Expect = 0.083
Identities = 71/367 (19%), Positives = 140/367 (38%), Gaps = 61/367 (16%)
Query: 251 NVQQLLSSPGTWRGRAQQILVLQ-----SKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+ Q SPG R ++Q L ++ +K++ L ++L + Q + + + +
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 306 KLSAQEKNLL---RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + NLL R + R++ + L + A D L+ E+ K++
Sbjct: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL------------- 336
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
HD E A +++LK+ ++L E +L+
Sbjct: 337 ----------------HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380
Query: 423 AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQ-LNVHYLRNKGVGEG-SSGREVSPAYTQF 480
+ + L A+L M ER+ +++E + + + + + + + E G E+ Q
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE----QI 436
Query: 481 LEDPGLTKSP-ASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
L+++P S G V L SSR L++ + SL DS E
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSR--------LLKLEMENQSLTKTVEELRTTVDSVE- 487
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLE 599
S+I + E E RL++ V +L+ + + L + ++ LE
Sbjct: 488 ----GNASKILKM----EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 600 QHLEKIR 606
+ +E +R
Sbjct: 540 KTIETLR 546
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 79.0 bits (193), Expect = 1e-14
Identities = 138/631 (21%), Positives = 267/631 (42%), Gaps = 106/631 (16%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+A D +++N ++ K M + + +K E ++EKE + ++E L++
Sbjct: 273 IAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR------ 326
Query: 61 HAGEPNSKNSFEKRVLE--DEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEED 118
K + EK++ + E+E N++++ E GRL++L + ++ E L ++I++
Sbjct: 327 -----KEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKL 381
Query: 119 RFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTR 178
+ + + + ++++ L AE + K +L +E T LT+
Sbjct: 382 K-----------EDINSHVIKVKWAQNKLKAEMDSHKETKDKL--------KETTTKLTQ 422
Query: 179 LSAKGATDAGAKPPRAQMGDRALLETPEVKA--LQDRLVATNLKMSDLRNQIQSVKQELR 236
AK D K Q + E+ E+K+ L +L T +L Q+Q +L
Sbjct: 423 --AKEEADQIRK--NCQDMIKTYQESEEIKSNELDAKLRVTK---GELEKQMQEKSDQLE 475
Query: 237 MAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASD 296
M +++L T++ ++ L++KV+ LE + + R++ D
Sbjct: 476 M----------HHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE--RLRTE------D 517
Query: 297 ELSVYPD-PRKLSAQEKNLL-RIRS-------LEREKQEGLEKLASERDVLQRELEELKK 347
ELS Y + + A+ +NLL ++++ L+R KQE +E L E + L + +L+K
Sbjct: 518 ELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSLINDLQK 576
Query: 348 KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEK 407
EG R R L + L S+ L + D + QLQ Q E+
Sbjct: 577 DIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQS-------QCEQ 629
Query: 408 TRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEG 467
+ + +L+ +L E + V LQA +A R+ +V+ L ++ +L + +
Sbjct: 630 MKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRR-KHA 688
Query: 468 SSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPH 527
SS +++ T+ L+ +G + + V+S+G S S +
Sbjct: 689 SSIKDL----TKQLQQARRKLDQVESGSY------DKEVSSMGSRSSSSG-------SLN 731
Query: 528 RTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKL--LESE 585
S SPE G V +V++ L E + LQK N K+ +E
Sbjct: 732 ARSSAEDRSPENTGSSVAVDNF------PQVDKAMLIERIVRLQKAHARKNEKIEFMEDH 785
Query: 586 RK--LQEERHRTVVLEQHLEKIRLEPGKASA 614
K ++E R +T +++ ++ +R E G S+
Sbjct: 786 IKQLVEEIRKKTKIIQSYI--LREESGTLSS 814
Score = 53.5 bits (127), Expect = 7e-07
Identities = 96/435 (22%), Positives = 188/435 (43%), Gaps = 96/435 (22%)
Query: 77 EDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATK 136
ED +E + +EL T R+ + + + + L +K +D++ + + + K
Sbjct: 160 EDLLEEIESELLSTEFAEHRVPNGMNKGEHALV-LFEKCVQDKY-------LQQEHIIKK 211
Query: 137 IVELSKKNRLLMAE--------SEGAKTR----------VKQLTNRIQELERELQTALTR 178
+++ +KK++ L + E K R +KQL +RI+EL +E++ + +
Sbjct: 212 LIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQ 271
Query: 179 LSAKGATDAGA----KPPRAQMGDRALLETPEVKALQDRLVATNLK----MSDLRNQIQS 230
L A+ T A AQ ++A + E + ++ +V ++ DLR + ++
Sbjct: 272 LIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKET 331
Query: 231 VKQELRMAQKVLAR----------------------------------EVGEDIN--VQQ 254
++++LR A K L + ++ EDIN V +
Sbjct: 332 LEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIK 391
Query: 255 LLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR---SQSAGTASDELSVYPDPRKLSAQE 311
+ + + + K++E +L QA+ Q D + Y + ++ + E
Sbjct: 392 VKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 451
Query: 312 KNL-LRIR--SLEREKQEGLEKLASERDVLQRELEELKKKF-EGMRSRNKLLSSEMKTLK 367
+ LR+ LE++ QE ++L + +ELE+LK+ F EGM E++TL+
Sbjct: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKI-KELEDLKRTFKEGM--------DELRTLR 502
Query: 368 SQMGTLV-EKGRHDDELI---DALMDQLKQLQEILGSL----SLQEEKTRVSQHHLDQQL 419
+++ L E+ R +DEL + + Q ++Q +L + LQE+ R Q + L
Sbjct: 503 TKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQE--IENL 560
Query: 420 NSEAQRSNSLVAQLQ 434
E + NSL+ LQ
Sbjct: 561 KEEVESLNSLINDLQ 575
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 78.6 bits (192), Expect = 2e-14
Identities = 169/807 (20%), Positives = 306/807 (37%), Gaps = 167/807 (20%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
+E S+ + + Q +Q + E+ ++L L+ + + + + + L LL
Sbjct: 960 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLE-- 1016
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ NSK S E+++LED + ++ E ++ L KL + + I ++ ++ ++
Sbjct: 1017 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1076
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL-------ERELQTAL 176
EL K R L ES + ++ + R +EL E ELQ AL
Sbjct: 1077 ---------------ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1121
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMS--DLRNQIQSVKQE 234
R +G A A+ ++ +A L + +R+ T + DL ++++++ E
Sbjct: 1122 ARAEDEGG--ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1179
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEK-------QLGQAR 287
L + + N QQ L S R Q++ L+ ++E + +L Q
Sbjct: 1180 LE--------DTLDSTNAQQELRSK-----REQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK 347
Q+ G +++L R A EK L +LE E E L+ EL L+
Sbjct: 1227 GQALGELAEQLE--QARRGKGAWEKTRL---ALEAEVSE-----------LRAELSSLQT 1270
Query: 348 KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEK 407
+ R + L +++ ++ + G + R E + L +L+ + G+L+ E K
Sbjct: 1271 ARQEGEQRRRRLELQLQEVQGRAG---DGERARAEAAEKLQRAQAELENVSGALNEAESK 1327
Query: 408 T-RVSQ---------HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
T R+S+ H + L E + +L ++++AM AE QLE E
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------- 1380
Query: 458 YLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASA--GDHVGRLGSSRSVTSLGHTLVE 515
+GRE+ A Q E + A A R ++R +L L E
Sbjct: 1381 -----AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1435
Query: 516 SALTRPSLPSPHRTSPRFSDSP----------------EQKGWQAQVSEIKALWQAAEVE 559
T L R + D +Q+ + ++E KA A E
Sbjct: 1436 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495
Query: 560 RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE----------P 609
R+R + E ++ L R L+EE+ LE+ +R E
Sbjct: 1496 RERA-------EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1548
Query: 610 GKA-----------------------------SASQRAAPRTKTGLPTSNNRH------- 633
GK+ +A++ A R + + +H
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608
Query: 634 NPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVE-----ENEMLKAALGSALRGKEED 688
+ G E++ QL D VE E LA+ E E LKA + SA +GKEE
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668
Query: 689 FRMYHEILGQVKSVFLQALRQQKTGKQ 715
+ ++ Q+K ++ + + + +T ++
Sbjct: 1669 VKQLRKMQAQMKELW-REVEETRTSRE 1694
Score = 76.3 bits (186), Expect = 9e-14
Identities = 143/653 (21%), Positives = 248/653 (37%), Gaps = 90/653 (13%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
M + LR Q +E L + ++ + LKS + Q E + L
Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
++ ++R L +E+E LR EL +T+D +L +R+ E+ LKK +EE+
Sbjct: 1156 RVARTKAEK--QRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1213
Query: 121 AFTGTA-------GVAGDVVATKIVELSK------KNRL-LMAESEGAKTRVKQLTNRIQ 166
G A +A ++ + + K RL L AE + + L Q
Sbjct: 1214 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1273
Query: 167 ELE---RELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKA-----------LQD 212
E E R L+ L + + A+ A+ RA E V L
Sbjct: 1274 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1333
Query: 213 RLVATNLKMSDLRNQIQ-SVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILV 271
L +T ++ D + +Q + +L + +V A E E +++ L R RA +
Sbjct: 1334 ELSSTEAQLHDAQELLQEETRAKLALGSRVRAME-AEAAGLREQLEEEAAARERAGR--- 1389
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
++Q + QL + R + A L + R+ +A+E L R EK E +++L
Sbjct: 1390 ---ELQTAQAQLSEWRRRQEEEAG-ALEAGEEARRRAAREAEALTQRL--AEKTETVDRL 1443
Query: 332 ASERDVLQRE-----------------LEELKKKFEGMRSRNKL-----------LSSEM 363
R LQ+E LE+ ++KF+ + + K +E
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503
Query: 364 KTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEA 423
+ +++ +L + E + L Q + L+ L +L ++ S H L++
Sbjct: 1504 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE 1563
Query: 424 QRSNSLVAQL----QAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQ 479
Q +N L AQ+ + A +AK+R LE+ + L + R+ G +G E +
Sbjct: 1564 QAANDLRAQVTELEDELTAAEDAKLR-LEVTVQALKTQHERDL-QGRDEAGEERRRQLAK 1621
Query: 480 FLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
L D + + R++ +E L + +
Sbjct: 1622 QLRDAEVERDEER---------KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESE-RKLQEE 591
+ QAQ+ E LW+ EVE R + Q R E K LE+E +LQEE
Sbjct: 1673 RKMQAQMKE---LWR--EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1720
Score = 55.1 bits (131), Expect = 2e-07
Identities = 129/564 (22%), Positives = 221/564 (39%), Gaps = 57/564 (10%)
Query: 161 LTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLK 220
L R QEL++ + L + A + G R + E + L A +
Sbjct: 879 LQARAQELQK-----VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA---E 930
Query: 221 MSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELE 280
+ R ++ + KQEL + L VGE+ + + T + R LQ +QELE
Sbjct: 931 AEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ---TEKKR------LQQHIQELE 981
Query: 281 KQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQR 340
L ++ +L K+ E++LL + ++ KL+ ER +L+
Sbjct: 982 AHL---EAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------EDQNSKLSKERKLLED 1031
Query: 341 ELEELK----KKFEGMRSRNKLLSSEMKTLKSQMGTL--VEKGRHDDELIDALMD-QLKQ 393
L E ++ E ++S NKL T+ L EKGR + E + +D + +
Sbjct: 1032 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSE 1091
Query: 394 LQEILGSLSLQEEKTRVSQHHLDQQLNSE-AQRSNSLVAQLQAMVAEREAKVRQLEMEIG 452
LQE + + E+ R +++L + A+ + A+ Q + + REA+ E +
Sbjct: 1092 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151
Query: 453 QLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHT 512
+ R K + E A LED T +A + R + VT L T
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELED---TLDSTNAQQEL-RSKREQEVTELKKT 1207
Query: 513 LVESALTRPSLPSPHRTSPRFSDSPEQKGWQ-AQVSEIKALWQAAEVERDRLTEFVTVLQ 571
L E TR + R + + Q Q K W E+ RL V +
Sbjct: 1208 LEEE--TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW-----EKTRLALEAEVSE 1260
Query: 572 KRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSN- 630
R E S+ L++ R+ E+R R LE L++++ G+A +RA L +
Sbjct: 1261 LRAELSS---LQTARQEGEQRRRR--LELQLQEVQ---GRAGDGERARAEAAEKLQRAQA 1312
Query: 631 NRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
N +G+ + S + S +L + ++E K ALGS +R E +
Sbjct: 1313 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQEL-LQEETRAKLALGSRVRAMEAEAA 1371
Query: 691 MYHEILGQVKSVFLQALRQQKTGK 714
E L + + +A R+ +T +
Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQ 1395
Score = 52.8 bits (125), Expect = 1e-06
Identities = 83/380 (21%), Positives = 165/380 (43%), Gaps = 53/380 (13%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEV---SDGLSLL 60
DE+ + R K +++ + +R +++ K+R ++ + + + + E L+ S G
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASAGQGKE 1666
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEED-- 118
A + K + + L E+E R E +N K LK + E+ L++++
Sbjct: 1667 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1726
Query: 119 --RFAFTGTAGVAGDVV---ATKIVELSKKNRL------LMAESEGAKTRVKQLTNRIQE 167
R A +A +V +K L +K +L L E E ++ + L +R ++
Sbjct: 1727 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1786
Query: 168 LERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQ 227
L ++++ T LSA+ + A A+ R Q+ +R + E +D KM+
Sbjct: 1787 LLLQVESLTTELSAERSFSAKAESGRQQL-ERQIQELRGRLGEEDAGARARHKMT----- 1840
Query: 228 IQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR 287
I +++ +L A++ L +E E I +L+ R +++ + +V+E + Q R
Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKLV------RRAEKRLKEVVLQVEEERRVADQLR 1894
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLA---SERDVLQRELEE 344
Q EK LR++ L+R+ +E E+ + + R LQRELE+
Sbjct: 1895 DQL--------------------EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1934
Query: 345 LKKKFEGMRSRNKLLSSEMK 364
+ + E M L + ++
Sbjct: 1935 VTESAESMNREVTTLRNRLR 1954
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/453 (21%), Positives = 184/453 (40%), Gaps = 43/453 (9%)
Query: 12 RLQFKAMQEMQHKRLQKQ-----MEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPN 66
R + +A +++Q + + + + + K + L E L D LL E
Sbjct: 1298 RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH--DAQELLQE-ETR 1354
Query: 67 SKNSFEKRV--LEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
+K + RV +E E LR +L E R + L+ ++ +++ EE+ A
Sbjct: 1355 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1413
Query: 125 TAGVAGDVVATKIVE-----LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRL 179
AG A + E L++K + G + ++L + +LE++ Q T
Sbjct: 1414 -AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1472
Query: 180 SAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQ 239
+ D +A + RA+ E +A A L ++ + Q ++EL
Sbjct: 1473 KKQRKFDQLLAEEKAAVL-RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1531
Query: 240 KVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELS 299
+ L E+ + LLSS + + L+ + E+ R+Q DEL+
Sbjct: 1532 RALRAEL------EALLSSKDDV---GKSVHELERACRVAEQAANDLRAQVT-ELEDELT 1581
Query: 300 VYPDPR---KLSAQEKNLLRIRSLEREKQEGLEK---LASE-RDVLQRELEELKKKFEGM 352
D + +++ Q R L+ + G E+ LA + RD EE K++ +
Sbjct: 1582 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1641
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ 412
+R KL E++ LK+QM + G+ +E + QL+++Q + L + E+TR S+
Sbjct: 1642 AARKKL-EGELEELKAQMASA---GQGKEEAVK----QLRKMQAQMKELWREVEETRTSR 1693
Query: 413 HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVR 445
+ Q +R L A++ + E A R
Sbjct: 1694 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1726
Score = 49.7 bits (117), Expect = 1e-05
Identities = 101/487 (20%), Positives = 199/487 (40%), Gaps = 86/487 (17%)
Query: 22 QHKRLQKQMEKKREK-------ELSLKSRADDQEEPLEVSD------GLSLLHA--GEPN 66
Q ++L +EKK+ K E + RA ++ E E LSL A E
Sbjct: 1463 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1522
Query: 67 SKNSFEK--RVLEDEIEHL---RNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA 121
++ E+ R L E+E L ++++ ++V E R ++ ++ +++ ++E++
Sbjct: 1523 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE--- 1579
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELE----RELQTALT 177
T + T ++ R L E + R +QL ++++ E E +
Sbjct: 1580 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1639
Query: 178 RLSAKGATDAGAKPPRAQMGDRALLETPEVKAL---QDRLVATNLKMSDLRNQIQSVKQE 234
++A+ + + +AQM + VK L Q ++ ++ + R + + +
Sbjct: 1640 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1699
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ----------------ILVLQSKVQE 278
R ++K L E + +Q+ L++ R +AQQ +L+ K ++
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK-RQ 1758
Query: 279 LEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVL 338
LE +LGQ + S+ + RKL Q ++L S ER K S R L
Sbjct: 1759 LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA---KAESGRQQL 1815
Query: 339 QRELEELKKKF----EGMRSRNKL----LSSEMKTLKSQM----------GTLV------ 374
+R+++EL+ + G R+R+K+ L S++ + Q+ G LV
Sbjct: 1816 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1875
Query: 375 ---------EKGRHDDELIDALMD---QLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
E+ R D+L D L ++KQL+ L + + + + L ++L
Sbjct: 1876 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1935
Query: 423 AQRSNSL 429
+ + S+
Sbjct: 1936 TESAESM 1942
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 78.6 bits (192), Expect = 2e-14
Identities = 169/807 (20%), Positives = 306/807 (37%), Gaps = 167/807 (20%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
+E S+ + + Q +Q + E+ ++L L+ + + + + + L LL
Sbjct: 952 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLE-- 1008
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ NSK S E+++LED + ++ E ++ L KL + + I ++ ++ ++
Sbjct: 1009 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1068
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL-------ERELQTAL 176
EL K R L ES + ++ + R +EL E ELQ AL
Sbjct: 1069 ---------------ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1113
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMS--DLRNQIQSVKQE 234
R +G A A+ ++ +A L + +R+ T + DL ++++++ E
Sbjct: 1114 ARAEDEGG--ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1171
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEK-------QLGQAR 287
L + + N QQ L S R Q++ L+ ++E + +L Q
Sbjct: 1172 LE--------DTLDSTNAQQELRSK-----REQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK 347
Q+ G +++L R A EK L +LE E E L+ EL L+
Sbjct: 1219 GQALGELAEQLE--QARRGKGAWEKTRL---ALEAEVSE-----------LRAELSSLQT 1262
Query: 348 KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEK 407
+ R + L +++ ++ + G + R E + L +L+ + G+L+ E K
Sbjct: 1263 ARQEGEQRRRRLELQLQEVQGRAG---DGERARAEAAEKLQRAQAELENVSGALNEAESK 1319
Query: 408 T-RVSQ---------HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
T R+S+ H + L E + +L ++++AM AE QLE E
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------- 1372
Query: 458 YLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASA--GDHVGRLGSSRSVTSLGHTLVE 515
+GRE+ A Q E + A A R ++R +L L E
Sbjct: 1373 -----AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1427
Query: 516 SALTRPSLPSPHRTSPRFSDSP----------------EQKGWQAQVSEIKALWQAAEVE 559
T L R + D +Q+ + ++E KA A E
Sbjct: 1428 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487
Query: 560 RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE----------P 609
R+R + E ++ L R L+EE+ LE+ +R E
Sbjct: 1488 RERA-------EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1540
Query: 610 GKA-----------------------------SASQRAAPRTKTGLPTSNNRH------- 633
GK+ +A++ A R + + +H
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600
Query: 634 NPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVE-----ENEMLKAALGSALRGKEED 688
+ G E++ QL D VE E LA+ E E LKA + SA +GKEE
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660
Query: 689 FRMYHEILGQVKSVFLQALRQQKTGKQ 715
+ ++ Q+K ++ + + + +T ++
Sbjct: 1661 VKQLRKMQAQMKELW-REVEETRTSRE 1686
Score = 76.3 bits (186), Expect = 9e-14
Identities = 143/653 (21%), Positives = 248/653 (37%), Gaps = 90/653 (13%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
M + LR Q +E L + ++ + LKS + Q E + L
Sbjct: 1088 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1147
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
++ ++R L +E+E LR EL +T+D +L +R+ E+ LKK +EE+
Sbjct: 1148 RVARTKAEK--QRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1205
Query: 121 AFTGTA-------GVAGDVVATKIVELSK------KNRL-LMAESEGAKTRVKQLTNRIQ 166
G A +A ++ + + K RL L AE + + L Q
Sbjct: 1206 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1265
Query: 167 ELE---RELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKA-----------LQD 212
E E R L+ L + + A+ A+ RA E V L
Sbjct: 1266 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1325
Query: 213 RLVATNLKMSDLRNQIQ-SVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILV 271
L +T ++ D + +Q + +L + +V A E E +++ L R RA +
Sbjct: 1326 ELSSTEAQLHDAQELLQEETRAKLALGSRVRAME-AEAAGLREQLEEEAAARERAGR--- 1381
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
++Q + QL + R + A L + R+ +A+E L R EK E +++L
Sbjct: 1382 ---ELQTAQAQLSEWRRRQEEEAG-ALEAGEEARRRAAREAEALTQRL--AEKTETVDRL 1435
Query: 332 ASERDVLQRE-----------------LEELKKKFEGMRSRNKL-----------LSSEM 363
R LQ+E LE+ ++KF+ + + K +E
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495
Query: 364 KTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEA 423
+ +++ +L + E + L Q + L+ L +L ++ S H L++
Sbjct: 1496 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE 1555
Query: 424 QRSNSLVAQL----QAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQ 479
Q +N L AQ+ + A +AK+R LE+ + L + R+ G +G E +
Sbjct: 1556 QAANDLRAQVTELEDELTAAEDAKLR-LEVTVQALKTQHERDL-QGRDEAGEERRRQLAK 1613
Query: 480 FLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
L D + + R++ +E L + +
Sbjct: 1614 QLRDAEVERDEER---------KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESE-RKLQEE 591
+ QAQ+ E LW+ EVE R + Q R E K LE+E +LQEE
Sbjct: 1665 RKMQAQMKE---LWR--EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1712
Score = 55.1 bits (131), Expect = 2e-07
Identities = 129/564 (22%), Positives = 221/564 (39%), Gaps = 57/564 (10%)
Query: 161 LTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLK 220
L R QEL++ + L + A + G R + E + L A +
Sbjct: 871 LQARAQELQK-----VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA---E 922
Query: 221 MSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELE 280
+ R ++ + KQEL + L VGE+ + + T + R LQ +QELE
Sbjct: 923 AEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ---TEKKR------LQQHIQELE 973
Query: 281 KQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQR 340
L ++ +L K+ E++LL + ++ KL+ ER +L+
Sbjct: 974 AHL---EAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------EDQNSKLSKERKLLED 1023
Query: 341 ELEELK----KKFEGMRSRNKLLSSEMKTLKSQMGTL--VEKGRHDDELIDALMD-QLKQ 393
L E ++ E ++S NKL T+ L EKGR + E + +D + +
Sbjct: 1024 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSE 1083
Query: 394 LQEILGSLSLQEEKTRVSQHHLDQQLNSE-AQRSNSLVAQLQAMVAEREAKVRQLEMEIG 452
LQE + + E+ R +++L + A+ + A+ Q + + REA+ E +
Sbjct: 1084 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143
Query: 453 QLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHT 512
+ R K + E A LED T +A + R + VT L T
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELED---TLDSTNAQQEL-RSKREQEVTELKKT 1199
Query: 513 LVESALTRPSLPSPHRTSPRFSDSPEQKGWQ-AQVSEIKALWQAAEVERDRLTEFVTVLQ 571
L E TR + R + + Q Q K W E+ RL V +
Sbjct: 1200 LEEE--TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW-----EKTRLALEAEVSE 1252
Query: 572 KRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSN- 630
R E S+ L++ R+ E+R R LE L++++ G+A +RA L +
Sbjct: 1253 LRAELSS---LQTARQEGEQRRRR--LELQLQEVQ---GRAGDGERARAEAAEKLQRAQA 1304
Query: 631 NRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
N +G+ + S + S +L + ++E K ALGS +R E +
Sbjct: 1305 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQEL-LQEETRAKLALGSRVRAMEAEAA 1363
Query: 691 MYHEILGQVKSVFLQALRQQKTGK 714
E L + + +A R+ +T +
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQ 1387
Score = 52.8 bits (125), Expect = 1e-06
Identities = 83/380 (21%), Positives = 165/380 (43%), Gaps = 53/380 (13%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEV---SDGLSLL 60
DE+ + R K +++ + +R +++ K+R ++ + + + + E L+ S G
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASAGQGKE 1658
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEED-- 118
A + K + + L E+E R E +N K LK + E+ L++++
Sbjct: 1659 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1718
Query: 119 --RFAFTGTAGVAGDVV---ATKIVELSKKNRL------LMAESEGAKTRVKQLTNRIQE 167
R A +A +V +K L +K +L L E E ++ + L +R ++
Sbjct: 1719 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1778
Query: 168 LERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQ 227
L ++++ T LSA+ + A A+ R Q+ +R + E +D KM+
Sbjct: 1779 LLLQVESLTTELSAERSFSAKAESGRQQL-ERQIQELRGRLGEEDAGARARHKMT----- 1832
Query: 228 IQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR 287
I +++ +L A++ L +E E I +L+ R +++ + +V+E + Q R
Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKLV------RRAEKRLKEVVLQVEEERRVADQLR 1886
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLA---SERDVLQRELEE 344
Q EK LR++ L+R+ +E E+ + + R LQRELE+
Sbjct: 1887 DQL--------------------EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1926
Query: 345 LKKKFEGMRSRNKLLSSEMK 364
+ + E M L + ++
Sbjct: 1927 VTESAESMNREVTTLRNRLR 1946
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/453 (21%), Positives = 184/453 (40%), Gaps = 43/453 (9%)
Query: 12 RLQFKAMQEMQHKRLQKQ-----MEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPN 66
R + +A +++Q + + + + + K + L E L D LL E
Sbjct: 1290 RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH--DAQELLQE-ETR 1346
Query: 67 SKNSFEKRV--LEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
+K + RV +E E LR +L E R + L+ ++ +++ EE+ A
Sbjct: 1347 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1405
Query: 125 TAGVAGDVVATKIVE-----LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRL 179
AG A + E L++K + G + ++L + +LE++ Q T
Sbjct: 1406 -AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1464
Query: 180 SAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQ 239
+ D +A + RA+ E +A A L ++ + Q ++EL
Sbjct: 1465 KKQRKFDQLLAEEKAAVL-RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1523
Query: 240 KVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELS 299
+ L E+ + LLSS + + L+ + E+ R+Q DEL+
Sbjct: 1524 RALRAEL------EALLSSKDDV---GKSVHELERACRVAEQAANDLRAQVT-ELEDELT 1573
Query: 300 VYPDPR---KLSAQEKNLLRIRSLEREKQEGLEK---LASE-RDVLQRELEELKKKFEGM 352
D + +++ Q R L+ + G E+ LA + RD EE K++ +
Sbjct: 1574 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1633
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ 412
+R KL E++ LK+QM + G+ +E + QL+++Q + L + E+TR S+
Sbjct: 1634 AARKKL-EGELEELKAQMASA---GQGKEEAVK----QLRKMQAQMKELWREVEETRTSR 1685
Query: 413 HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVR 445
+ Q +R L A++ + E A R
Sbjct: 1686 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1718
Score = 49.7 bits (117), Expect = 1e-05
Identities = 101/487 (20%), Positives = 199/487 (40%), Gaps = 86/487 (17%)
Query: 22 QHKRLQKQMEKKREK-------ELSLKSRADDQEEPLEVSD------GLSLLHA--GEPN 66
Q ++L +EKK+ K E + RA ++ E E LSL A E
Sbjct: 1455 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1514
Query: 67 SKNSFEK--RVLEDEIEHL---RNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA 121
++ E+ R L E+E L ++++ ++V E R ++ ++ +++ ++E++
Sbjct: 1515 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE--- 1571
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELE----RELQTALT 177
T + T ++ R L E + R +QL ++++ E E +
Sbjct: 1572 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1631
Query: 178 RLSAKGATDAGAKPPRAQMGDRALLETPEVKAL---QDRLVATNLKMSDLRNQIQSVKQE 234
++A+ + + +AQM + VK L Q ++ ++ + R + + +
Sbjct: 1632 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1691
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ----------------ILVLQSKVQE 278
R ++K L E + +Q+ L++ R +AQQ +L+ K ++
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK-RQ 1750
Query: 279 LEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVL 338
LE +LGQ + S+ + RKL Q ++L S ER K S R L
Sbjct: 1751 LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA---KAESGRQQL 1807
Query: 339 QRELEELKKKF----EGMRSRNKL----LSSEMKTLKSQM----------GTLV------ 374
+R+++EL+ + G R+R+K+ L S++ + Q+ G LV
Sbjct: 1808 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1867
Query: 375 ---------EKGRHDDELIDALMD---QLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
E+ R D+L D L ++KQL+ L + + + + L ++L
Sbjct: 1868 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1927
Query: 423 AQRSNSL 429
+ + S+
Sbjct: 1928 TESAESM 1934
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 78.6 bits (192), Expect = 2e-14
Identities = 169/807 (20%), Positives = 306/807 (37%), Gaps = 167/807 (20%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
+E S+ + + Q +Q + E+ ++L L+ + + + + + L LL
Sbjct: 993 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLE-- 1049
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ NSK S E+++LED + ++ E ++ L KL + + I ++ ++ ++
Sbjct: 1050 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1109
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL-------ERELQTAL 176
EL K R L ES + ++ + R +EL E ELQ AL
Sbjct: 1110 ---------------ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1154
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMS--DLRNQIQSVKQE 234
R +G A A+ ++ +A L + +R+ T + DL ++++++ E
Sbjct: 1155 ARAEDEGG--ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1212
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEK-------QLGQAR 287
L + + N QQ L S R Q++ L+ ++E + +L Q
Sbjct: 1213 LE--------DTLDSTNAQQELRSK-----REQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK 347
Q+ G +++L R A EK L +LE E E L+ EL L+
Sbjct: 1260 GQALGELAEQLE--QARRGKGAWEKTRL---ALEAEVSE-----------LRAELSSLQT 1303
Query: 348 KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEK 407
+ R + L +++ ++ + G + R E + L +L+ + G+L+ E K
Sbjct: 1304 ARQEGEQRRRRLELQLQEVQGRAG---DGERARAEAAEKLQRAQAELENVSGALNEAESK 1360
Query: 408 T-RVSQ---------HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
T R+S+ H + L E + +L ++++AM AE QLE E
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE------- 1413
Query: 458 YLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASA--GDHVGRLGSSRSVTSLGHTLVE 515
+GRE+ A Q E + A A R ++R +L L E
Sbjct: 1414 -----AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1468
Query: 516 SALTRPSLPSPHRTSPRFSDSP----------------EQKGWQAQVSEIKALWQAAEVE 559
T L R + D +Q+ + ++E KA A E
Sbjct: 1469 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528
Query: 560 RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE----------P 609
R+R + E ++ L R L+EE+ LE+ +R E
Sbjct: 1529 RERA-------EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1581
Query: 610 GKA-----------------------------SASQRAAPRTKTGLPTSNNRH------- 633
GK+ +A++ A R + + +H
Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641
Query: 634 NPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVE-----ENEMLKAALGSALRGKEED 688
+ G E++ QL D VE E LA+ E E LKA + SA +GKEE
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701
Query: 689 FRMYHEILGQVKSVFLQALRQQKTGKQ 715
+ ++ Q+K ++ + + + +T ++
Sbjct: 1702 VKQLRKMQAQMKELW-REVEETRTSRE 1727
Score = 76.3 bits (186), Expect = 9e-14
Identities = 143/653 (21%), Positives = 248/653 (37%), Gaps = 90/653 (13%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
M + LR Q +E L + ++ + LKS + Q E + L
Sbjct: 1129 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1188
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
++ ++R L +E+E LR EL +T+D +L +R+ E+ LKK +EE+
Sbjct: 1189 RVARTKAEK--QRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1246
Query: 121 AFTGTA-------GVAGDVVATKIVELSK------KNRL-LMAESEGAKTRVKQLTNRIQ 166
G A +A ++ + + K RL L AE + + L Q
Sbjct: 1247 IHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1306
Query: 167 ELE---RELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKA-----------LQD 212
E E R L+ L + + A+ A+ RA E V L
Sbjct: 1307 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1366
Query: 213 RLVATNLKMSDLRNQIQ-SVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILV 271
L +T ++ D + +Q + +L + +V A E E +++ L R RA +
Sbjct: 1367 ELSSTEAQLHDAQELLQEETRAKLALGSRVRAME-AEAAGLREQLEEEAAARERAGR--- 1422
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
++Q + QL + R + A L + R+ +A+E L R EK E +++L
Sbjct: 1423 ---ELQTAQAQLSEWRRRQEEEAG-ALEAGEEARRRAAREAEALTQRL--AEKTETVDRL 1476
Query: 332 ASERDVLQRE-----------------LEELKKKFEGMRSRNKL-----------LSSEM 363
R LQ+E LE+ ++KF+ + + K +E
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536
Query: 364 KTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEA 423
+ +++ +L + E + L Q + L+ L +L ++ S H L++
Sbjct: 1537 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE 1596
Query: 424 QRSNSLVAQL----QAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQ 479
Q +N L AQ+ + A +AK+R LE+ + L + R+ G +G E +
Sbjct: 1597 QAANDLRAQVTELEDELTAAEDAKLR-LEVTVQALKTQHERDL-QGRDEAGEERRRQLAK 1654
Query: 480 FLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
L D + + R++ +E L + +
Sbjct: 1655 QLRDAEVERDEER---------KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1705
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESE-RKLQEE 591
+ QAQ+ E LW+ EVE R + Q R E K LE+E +LQEE
Sbjct: 1706 RKMQAQMKE---LWR--EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1753
Score = 55.1 bits (131), Expect = 2e-07
Identities = 129/564 (22%), Positives = 221/564 (39%), Gaps = 57/564 (10%)
Query: 161 LTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLK 220
L R QEL++ + L + A + G R + E + L A +
Sbjct: 912 LQARAQELQK-----VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA---E 963
Query: 221 MSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELE 280
+ R ++ + KQEL + L VGE+ + + T + R LQ +QELE
Sbjct: 964 AEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ---TEKKR------LQQHIQELE 1014
Query: 281 KQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQR 340
L ++ +L K+ E++LL + ++ KL+ ER +L+
Sbjct: 1015 AHL---EAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------EDQNSKLSKERKLLED 1064
Query: 341 ELEELK----KKFEGMRSRNKLLSSEMKTLKSQMGTL--VEKGRHDDELIDALMD-QLKQ 393
L E ++ E ++S NKL T+ L EKGR + E + +D + +
Sbjct: 1065 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSE 1124
Query: 394 LQEILGSLSLQEEKTRVSQHHLDQQLNSE-AQRSNSLVAQLQAMVAEREAKVRQLEMEIG 452
LQE + + E+ R +++L + A+ + A+ Q + + REA+ E +
Sbjct: 1125 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184
Query: 453 QLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHT 512
+ R K + E A LED T +A + R + VT L T
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELED---TLDSTNAQQEL-RSKREQEVTELKKT 1240
Query: 513 LVESALTRPSLPSPHRTSPRFSDSPEQKGWQ-AQVSEIKALWQAAEVERDRLTEFVTVLQ 571
L E TR + R + + Q Q K W E+ RL V +
Sbjct: 1241 LEEE--TRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW-----EKTRLALEAEVSE 1293
Query: 572 KRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSN- 630
R E S+ L++ R+ E+R R LE L++++ G+A +RA L +
Sbjct: 1294 LRAELSS---LQTARQEGEQRRRR--LELQLQEVQ---GRAGDGERARAEAAEKLQRAQA 1345
Query: 631 NRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
N +G+ + S + S +L + ++E K ALGS +R E +
Sbjct: 1346 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQEL-LQEETRAKLALGSRVRAMEAEAA 1404
Query: 691 MYHEILGQVKSVFLQALRQQKTGK 714
E L + + +A R+ +T +
Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQ 1428
Score = 52.8 bits (125), Expect = 1e-06
Identities = 83/380 (21%), Positives = 165/380 (43%), Gaps = 53/380 (13%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEV---SDGLSLL 60
DE+ + R K +++ + +R +++ K+R ++ + + + + E L+ S G
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEER--KQRTLAVAARKKLEGELEELKAQMASAGQGKE 1699
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEED-- 118
A + K + + L E+E R E +N K LK + E+ L++++
Sbjct: 1700 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1759
Query: 119 --RFAFTGTAGVAGDVV---ATKIVELSKKNRL------LMAESEGAKTRVKQLTNRIQE 167
R A +A +V +K L +K +L L E E ++ + L +R ++
Sbjct: 1760 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1819
Query: 168 LERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQ 227
L ++++ T LSA+ + A A+ R Q+ +R + E +D KM+
Sbjct: 1820 LLLQVESLTTELSAERSFSAKAESGRQQL-ERQIQELRGRLGEEDAGARARHKMT----- 1873
Query: 228 IQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR 287
I +++ +L A++ L +E E I +L+ R +++ + +V+E + Q R
Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKLV------RRAEKRLKEVVLQVEEERRVADQLR 1927
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLA---SERDVLQRELEE 344
Q EK LR++ L+R+ +E E+ + + R LQRELE+
Sbjct: 1928 DQL--------------------EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1967
Query: 345 LKKKFEGMRSRNKLLSSEMK 364
+ + E M L + ++
Sbjct: 1968 VTESAESMNREVTTLRNRLR 1987
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/453 (21%), Positives = 184/453 (40%), Gaps = 43/453 (9%)
Query: 12 RLQFKAMQEMQHKRLQKQ-----MEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPN 66
R + +A +++Q + + + + + K + L E L D LL E
Sbjct: 1331 RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH--DAQELLQE-ETR 1387
Query: 67 SKNSFEKRV--LEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
+K + RV +E E LR +L E R + L+ ++ +++ EE+ A
Sbjct: 1388 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE- 1446
Query: 125 TAGVAGDVVATKIVE-----LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRL 179
AG A + E L++K + G + ++L + +LE++ Q T
Sbjct: 1447 -AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1505
Query: 180 SAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQ 239
+ D +A + RA+ E +A A L ++ + Q ++EL
Sbjct: 1506 KKQRKFDQLLAEEKAAVL-RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQN 1564
Query: 240 KVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELS 299
+ L E+ + LLSS + + L+ + E+ R+Q DEL+
Sbjct: 1565 RALRAEL------EALLSSKDDV---GKSVHELERACRVAEQAANDLRAQVT-ELEDELT 1614
Query: 300 VYPDPR---KLSAQEKNLLRIRSLEREKQEGLEK---LASE-RDVLQRELEELKKKFEGM 352
D + +++ Q R L+ + G E+ LA + RD EE K++ +
Sbjct: 1615 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1674
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ 412
+R KL E++ LK+QM + G+ +E + QL+++Q + L + E+TR S+
Sbjct: 1675 AARKKL-EGELEELKAQMASA---GQGKEEAVK----QLRKMQAQMKELWREVEETRTSR 1726
Query: 413 HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVR 445
+ Q +R L A++ + E A R
Sbjct: 1727 EEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1759
Score = 49.7 bits (117), Expect = 1e-05
Identities = 101/487 (20%), Positives = 199/487 (40%), Gaps = 86/487 (17%)
Query: 22 QHKRLQKQMEKKREK-------ELSLKSRADDQEEPLEVSD------GLSLLHA--GEPN 66
Q ++L +EKK+ K E + RA ++ E E LSL A E
Sbjct: 1496 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1555
Query: 67 SKNSFEK--RVLEDEIEHL---RNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA 121
++ E+ R L E+E L ++++ ++V E R ++ ++ +++ ++E++
Sbjct: 1556 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE--- 1612
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELE----RELQTALT 177
T + T ++ R L E + R +QL ++++ E E +
Sbjct: 1613 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1672
Query: 178 RLSAKGATDAGAKPPRAQMGDRALLETPEVKAL---QDRLVATNLKMSDLRNQIQSVKQE 234
++A+ + + +AQM + VK L Q ++ ++ + R + + +
Sbjct: 1673 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1732
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ----------------ILVLQSKVQE 278
R ++K L E + +Q+ L++ R +AQQ +L+ K ++
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEK-RQ 1791
Query: 279 LEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVL 338
LE +LGQ + S+ + RKL Q ++L S ER K S R L
Sbjct: 1792 LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA---KAESGRQQL 1848
Query: 339 QRELEELKKKF----EGMRSRNKL----LSSEMKTLKSQM----------GTLV------ 374
+R+++EL+ + G R+R+K+ L S++ + Q+ G LV
Sbjct: 1849 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1908
Query: 375 ---------EKGRHDDELIDALMD---QLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSE 422
E+ R D+L D L ++KQL+ L + + + + L ++L
Sbjct: 1909 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1968
Query: 423 AQRSNSL 429
+ + S+
Sbjct: 1969 TESAESM 1975
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 76.6 bits (187), Expect = 7e-14
Identities = 139/653 (21%), Positives = 266/653 (40%), Gaps = 132/653 (20%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQK---------QMEKKREKELSLKSRADDQEEPL 51
MA E Q L +Q + ++E++ R + ++EKK + S + + D ++ L
Sbjct: 1494 MAVQEREQK-LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 52 EVSDGLSLLHAGEPNSKNSFEKRVLED----------EIEHLRNELRETVDE----NGRL 97
+ L+L E + K +++++++ + HL +L E E + ++
Sbjct: 1553 VTLECLAL-ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611
Query: 98 YKL----------LKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLL 147
+ L L+ERD E+K +++IEE + +L ++++ L
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ-----------DLERRDQEL 1660
Query: 148 MAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGA------------TDAGAKPPRAQ 195
M + E + Q T + + LE +L+ L +G + G P +AQ
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720
Query: 196 MGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQL 255
G ++ L+D+ + + +++Q +K +L + L R+VGE L
Sbjct: 1721 RGSLEHMKL----ILRDKEKEVECQQEHI-HELQELKDQLEQQLQGLHRKVGE---TSLL 1772
Query: 256 LSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLL 315
LS R Q+I+VLQ ++QE +Q G+ + QS + DE
Sbjct: 1773 LSQ------REQEIVVLQQQLQEAREQ-GELKEQSLQSQLDEAQ---------------- 1809
Query: 316 RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV- 374
R+L + QE LE L E+ Q + E +K+K + ++ L TLK + G L
Sbjct: 1810 --RALAQRDQE-LEALQQEQQQAQGQEERVKEKADALQGA---LEQAHMTLKERHGELQD 1863
Query: 375 --EKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQ 432
E+ R +E + +++ L+E+LG L + + + L QQ +AQ
Sbjct: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923
Query: 433 LQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGR---EVSPAYTQFLEDPGLTKS 489
LQ + +A +++ + E+ L E S R E + A + L++
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALR---------AESQSSRHQEEAARARAEALQE------ 1968
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEI 549
A H G + H L ++ L+R S S + Q A +
Sbjct: 1969 -ALGKAHAALQGKEQ------HLLEQAELSR---------SLEASTATLQASLDACQAHS 2012
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHL 602
+ L +A ++ + + Q+ V++ L + + +L+ ++ R +LE+ L
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL 2065
Score = 64.3 bits (155), Expect = 4e-10
Identities = 163/757 (21%), Positives = 306/757 (40%), Gaps = 133/757 (17%)
Query: 11 LRLQFKAMQEMQHKRLQKQMEKKREK---ELSLKSRADDQEEPLEVSDGLS--------- 58
L + K +E+ + +Q++ REK E+ L++ D+++ E GLS
Sbjct: 713 LHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Query: 59 LLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLL---------KERDFEIK 109
L A + NS K LE +I+ + + +E + R KL +ERD +
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTV-TQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR 831
Query: 110 HLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELE 169
L + +E + A A + ++ E +K R + E AK ++ L ELE
Sbjct: 832 QLAQAEQEGKTALEQQKA-AHEKEVNQLREKWEKERS-WHQQELAKA-LESLEREKMELE 888
Query: 170 RELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVK-ALQDRLVATNLKMSDLRNQI 228
L+ T + A A + + LET + + +L + L+ T +++D Q+
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948
Query: 229 QSVKQELRMAQKVLAREVGEDINVQ------QLLSSPGTWRG-----RAQQILVLQSKVQ 277
+ ++Q++++ QK+ +E + Q +L + R + + +LQ K+
Sbjct: 949 ERLRQDMKV-QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM- 1006
Query: 278 ELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRI-RSLEREK----------QE 326
+L+KQ+ +SQ + V + ++ + + RI + LEREK ++
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 327 GLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDA 386
L L + Q+EL L++ + + K LS++M+ L+ ++ ++ D
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV---------KEKEADF 1117
Query: 387 LMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKV-- 444
L + + L+E+ S H +QQL + + AQLQ + E+++
Sbjct: 1118 LAQEAQLLEELEAS------------HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165
Query: 445 --------RQLEMEIGQLNVHYLRNKGVG-------EGSSGREVSPAYTQFLEDPGLTKS 489
Q + + +++ + +G E S G + +P+ D +S
Sbjct: 1166 LAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARS 1225
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVE----SALTRPSL-PSPHRTSPRFSDSPEQKG--- 541
G + L S+ +V S H L + + TR L + R +D+ +K
Sbjct: 1226 LFKRGPLLTAL-SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
Query: 542 -----WQAQVS---EIKALWQ----AAEVERDRLTEFVTVLQKRVEESNSKLLESERK-- 587
Q Q+S E K+ W+ + E E L E + LQ R+ + + +E++ +
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 588 -LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFA 646
LQ + +HL+ +E A A AA + L T+ S
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTAR-------------SAL 1388
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALR 683
+L + VES+ E A ++E LK A G AL+
Sbjct: 1389 KLKNEEVESERER-----AQALQEQGELKVAQGKALQ 1420
Score = 63.5 bits (153), Expect = 6e-10
Identities = 139/641 (21%), Positives = 260/641 (40%), Gaps = 97/641 (15%)
Query: 29 QMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELR 88
Q+E++ + S A+ L+V L E + +EK HL +L+
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVD-----LAEAEKRREALWEKNT------HLEAQLQ 669
Query: 89 ETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVEL---SKKNR 145
+ + L L++ E + ++KK+ E R + T++ +L +K+
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRH--------QQEAATTQLEQLHQEAKRQE 721
Query: 146 LLMA----ESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRAL 201
++A E E L R+Q +ER+ Q +L +G + A + L
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL--QGLSSA-----------KEL 768
Query: 202 LETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGT 261
LE+ +A Q V K L QIQ+V Q A++V+ E V+ L T
Sbjct: 769 LESSLFEAQQQNSVIEVTK-GQLEVQIQTVTQ----AKEVIQGE------VRCLKLELDT 817
Query: 262 WRGRAQQILVLQSKVQELEKQLGQARSQSAGTASD----ELSVYPDPRKLSAQEKNLLRI 317
R +A+Q ++ +Q G+ + A + +L + + Q++ +
Sbjct: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 318 RSLEREKQE---GLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV 374
SLEREK E L++ +E + +Q + EE E ++ + L +++T K ++ L
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREE-----ERTQAESALCQMQLETEKERVSLLE 932
Query: 375 EKGRHDDELIDALMDQLKQLQEILGSLSLQEEKT----RVSQHHLDQQLNSEAQRSNSLV 430
+ EL DA QL++L++ + L+E++T + ++L A++ +
Sbjct: 933 TLLQTQKELADA-SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 431 AQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSP 490
A LQ E + + Q +M++ Q V L+++ V + S R V + L +
Sbjct: 992 AALQ----EESSSLLQDKMDL-QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET------ 1040
Query: 491 ASAGDHVGRLGS--SRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSE 548
R+ R SL +L+E L +DS Q+ ++S
Sbjct: 1041 ----QEYNRIQKELEREKASLTLSLMEKEQRLLVLQE--------ADSIRQQ----ELSA 1084
Query: 549 IKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLE-KIRL 607
++ Q A+ E+ L+ + +L++ V+E + L E +L EE + + EQ L +
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144
Query: 608 EPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQL 648
+ KA+ Q T++ L P + A L
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL 1185
Score = 61.2 bits (147), Expect = 3e-09
Identities = 133/628 (21%), Positives = 246/628 (39%), Gaps = 94/628 (14%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+A E TLR Q + +++ Q++M+K + LSL + +QE L+
Sbjct: 1430 LAEREEEVETLRGQIQELEK------QREMQKAALELLSLDLKKRNQEVDLQ-------- 1475
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
+ E +EHL ++E R KL +R+ +I+ L+K E R
Sbjct: 1476 ------QEQIQELEKCRSVLEHLPMAVQE------REQKLTVQRE-QIRELEKDRETQR- 1521
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
+V+ +++EL KK++++ ++ + KQL ++ L EL+ ++
Sbjct: 1522 ----------NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELEENHHKME 1570
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK------QE 234
+ + L++ E + R+ T+L + DL + Q ++ +
Sbjct: 1571 CQ----------------QKLIKELEGQRETQRVALTHLTL-DLEERSQELQAQSSQIHD 1613
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTA 294
L VLARE+ E Q++ S + +QI LQ + + L + L + R Q
Sbjct: 1614 LESHSTVLARELQE--RDQEVKS-------QREQIEELQRQKEHLTQDL-ERRDQELMLQ 1663
Query: 295 SDELSVYPDPRKLSAQ--EKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGM 352
+ + V D R + E++L +I+ RE+ +L ++R ++Q EE K +
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR---ELTTQRQLMQERAEEGKGPSKAQ 1720
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ 412
R + + ++ + ++ E EL D L QL+ L +G SL +
Sbjct: 1721 RGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 413 HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGRE 472
L QQL ++ LQ+ + E + + Q + E+ L + + G+ +E
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE--QQQAQGQEERVKE 1838
Query: 473 VSPAYTQFLEDPGLT--KSPASAGDH---VGRLGSSRSVTSLGHTLVESALTRPSLPSPH 527
+ A LE +T + DH RL +V +E L
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG-------- 1890
Query: 528 RTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
R ++K A + Q EVE L + Q ++E + +L +
Sbjct: 1891 --DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASAS 615
Q RH+ E ++ GKA A+
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAA 1976
Score = 54.7 bits (130), Expect = 3e-07
Identities = 99/483 (20%), Positives = 206/483 (42%), Gaps = 63/483 (13%)
Query: 5 ESSQNTLRLQFKAMQEMQHKR------LQKQME------KKREKELS-----LKSRADDQ 47
E L LQ + +Q ++ +R L++ +E ++R +EL+ ++ RA++
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG 1713
Query: 48 EEPLEVSDGLSLLHAG----------EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRL 97
+ P + G SL H E ++ E + L+D++E L V E L
Sbjct: 1714 KGPSKAQRG-SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 98 YKLLKERDFEIKHLKKKIEEDRFAFT---GTAGVAGDVVATKIVELSKKNRLLMAESEGA 154
L +R+ EI L+++++E R + D + + ++ L E + A
Sbjct: 1773 ---LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829
Query: 155 KTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRL 214
+ + +++ + L+ L+ A L + K ++ + +E V+AL++ L
Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL 1889
Query: 215 VATNLKMSDLRNQIQSVKQELRMAQKVLAREVGE-DINVQQL----LSSPGTWRGRAQQI 269
DLR + + ++ L Q+ A + E ++ + L L + + R Q++
Sbjct: 1890 -------GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQEL 1942
Query: 270 LVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLE 329
L+++ Q Q AR+++ ++ L +E++LL L R +
Sbjct: 1943 EALRAESQSSRHQEEAARARAEALQE---ALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 330 KLASERDVLQ---RELEELKKKFEG-MRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELID 385
L + D Q R+LEE + EG ++ ++ +++ L+ + E+ RH E
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059
Query: 386 ALMDQLKQ-LQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKV 444
L L Q +QE ++ +EK + Q ++++ Q V +LQ +A++E ++
Sbjct: 2060 LLEKSLAQRVQE-----NMIQEKQNLGQEREEEEIRGLHQS----VRELQLTLAQKEQEI 2110
Query: 445 RQL 447
+L
Sbjct: 2111 LEL 2113
Score = 54.3 bits (129), Expect = 4e-07
Identities = 95/453 (20%), Positives = 186/453 (41%), Gaps = 39/453 (8%)
Query: 24 KRLQKQMEKKREKELSLKSRADDQEEPLE--VSDGLSLLHAGEPNSKNSFEKRV--LEDE 79
+ L+K+ ++ ++ + LKS+ D ++ L+ V++ LS L +EK + L +
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTE-LSALLTQSQKQNEDYEKMIKALRET 312
Query: 80 IEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVE 139
+E L E ++ L + +E ++ + K I + + ++
Sbjct: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELD 372
Query: 140 LSKKNRLLMAESEGAKTRVKQLTNR----IQELEREL---QTALTRLSAKG---ATDAGA 189
S ++ +++ A T V+ + R +Q+L ++L Q A+ L + + A
Sbjct: 373 SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA 432
Query: 190 KPPRAQM--GDRALL--ETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLARE 245
R Q G+R L +T +++ D L S R +Q ++ELR +VL +E
Sbjct: 433 LRQRLQKLTGERDTLAGQTVDLQGEVDSL-------SKERELLQKAREELRQQLEVLEQE 485
Query: 246 VGE--DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQ----LGQARSQSAGTASDELS 299
+NV+ L + +Q L V+E E+ +G QS + EL
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS--ELI 543
Query: 300 VYPDPRKLSAQEKNLLRIRSLE-----REKQEGLEKLASERDVLQRELEELKKKFEGMRS 354
+ + S E LLR E ++ + +L+S + L+ E+ +L+ + +
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 355 RNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHH 414
N+ L+ + L Q+ L E+ + ++A LQ L + E H
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 415 LDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQL 447
L+ QL + L A L+ + E+E ++L
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Score = 53.5 bits (127), Expect = 7e-07
Identities = 81/350 (23%), Positives = 147/350 (42%), Gaps = 25/350 (7%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKR--EKELSLKSRADDQEEPLEVSDGLSLLHA 62
++ Q L ++E +H LQ E+ R E+EL+++ R E EV L
Sbjct: 1841 DALQGALEQAHMTLKE-RHGELQDHKEQARRLEEELAVEGRRVQALE--EVLGDLRAESR 1897
Query: 63 GEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF-- 120
+ + + +++ E EH E R D + +LKERD E++ L+ + + R
Sbjct: 1898 EQEKALLALQQQCAEQAQEH-EVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956
Query: 121 -AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRL 179
A A + + L K + L+ ++E L+ ++ LQ +L
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAE--------LSRSLEASTATLQASLDAC 2008
Query: 180 SAKGAT-DAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMA 238
A + + ++ D+ L +V+ LQ L + ++ + + Q +++ L A
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL--A 2066
Query: 239 QKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDEL 298
Q+V + E N+ Q RG Q + LQ + + E+++ + R + L
Sbjct: 2067 QRVQENMIQEKQNLGQEREEEEI-RGLHQSVRELQLTLAQKEQEILELRETQQ---RNNL 2122
Query: 299 SVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL-ASERDVLQRELEELKK 347
P K S E+ L++ SLE Q LE+L A+ R RE+E +K
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172
Score = 51.2 bits (121), Expect = 3e-06
Identities = 146/746 (19%), Positives = 292/746 (39%), Gaps = 105/746 (14%)
Query: 2 AADESSQNTLRLQFKAMQEMQHKRLQKQME----KKREKELSLKSR--------ADDQEE 49
AA E N LR +++ + + L K +E +K E E+ LK + A +EE
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE 908
Query: 50 PLEVSDGLSLLHAGEPNSKNSFEKRVLE---------DEIEHLRNELR----ETVDENGR 96
+ L + + S + +L+ ++E LR +++ + + G
Sbjct: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
Query: 97 LYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVA----------GDVVATKIVELSKKNRL 146
L L+E E+K ++ +D A + + + +++V RL
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Query: 147 LMAESEGAKTRVKQLTNRIQ-ELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETP 205
+ E + K R Q NRIQ ELERE + L K + + + +
Sbjct: 1029 VEQEVQ-EKLRETQEYNRIQKELEREKASLTLSLMEK-------EQRLLVLQEADSIRQQ 1080
Query: 206 EVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK-VLAREVGEDINVQQLLSSPGTWRG 264
E+ AL+ + + +L Q++ ++QE++ + LA+E +++L +S T +
Sbjct: 1081 ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITEQQ 1137
Query: 265 RAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREK 324
+ ++K +L+ +L SQ A+++ + Q + ++ SL
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ--------QPGNQAQAQAQLASLYSAL 1189
Query: 325 QEGLEKLASERDVLQRELEE------LKKKFEGMRS---RNKLLSS-EMKTLKSQMGTLV 374
Q+ L + R L + L+ G RS R LL++ + + S + L
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 375 EKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQ-------RSN 427
+ + D L DQ+++L+E L ++ + L +QL+ + + N
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 428 SLVAQLQAM---VAEREAKVRQLEMEIGQLNVHYLRNKGVGEG---SSGREVSPAYTQFL 481
SL ++L + +A ++++R+ E++ R + GE + +E A + L
Sbjct: 1310 SLESELMELHETMASLQSRLRRAELQ---------RMEAQGERELLQAAKENLTAQVEHL 1360
Query: 482 EDPGL-TKSPASAGDHVGR-LGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
+ + ++ ASA + L ++RS L + VES R Q
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 540 KGW----------QAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQ 589
+ + +V ++ Q E +R+ + +L +++ N ++ + ++Q
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 590 EERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNN--RHNPTGSEKKDPSFAQ 647
E VLE ++ K + + + T N H EKKD +
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKD-QMIE 1539
Query: 648 LSDVPVESQMEELTTR--LAIQVEEN 671
V+ ++L T LA+++EEN
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEEN 1565
Score = 41.6 bits (96), Expect = 0.003
Identities = 106/527 (20%), Positives = 213/527 (40%), Gaps = 66/527 (12%)
Query: 136 KIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQ 195
+++ L K + L E+ + QL ++ + ELQ +T LSA T + + +
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSAL-LTQSQKQNEDYE 303
Query: 196 MGDRALLETPEV-KALQDRLVATNLKMS-DLRNQIQSVKQELRMAQKVLAREVGEDI--- 250
+AL ET E+ + L+ +S + + + S++Q ++ +V+ E G++I
Sbjct: 304 KMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEE-GDNIAQG 362
Query: 251 -------NVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPD 303
+ + S ++ + + +++S + + + R Q AG + +++
Sbjct: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG-CQEAVNLLQQ 421
Query: 304 PRKLSAQEKNLLRIR----SLEREKQEG--------LEKLASERDVLQRELEELKKKFEG 351
+E LR R + ER+ G ++ L+ ER++LQ+ EEL+++ E
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 352 MRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKT--- 408
+ L L+ Q + + E + + + ++LQE+L L ++ ++
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 409 ------RVSQHHLD-QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRN 461
+ HL+ + L E + +A+ + +AE + L+ E+ L ++
Sbjct: 542 LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601
Query: 462 KGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRP 521
+ E + +V Q L+ +S S + + ++ +L L E+ R
Sbjct: 602 SALNEALALDKVG-LNQQLLQLEEENQSVCSRME-----AAEQARNALQVDLAEAEKRRE 655
Query: 522 SLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKL 581
+L W+ + ++A Q AE L + +Q+ EE KL
Sbjct: 656 AL------------------WEKN-THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 582 LESERKLQEERHRTVVLEQHLEKIRLEPGKASASQ--RAAPRTKTGL 626
SE + Q+E T + + H E R E A A Q A R K L
Sbjct: 697 --SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/504 (23%), Positives = 222/504 (44%), Gaps = 100/504 (19%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLS--LLHA 62
E +N+L+ Q + +E + K L+KQ+ + + K + DD +E + LL
Sbjct: 1342 EEEKNSLQEQQEEEEEAR-KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 63 GEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAF 122
E S+ EK + D++E +N L++ +D+ ++ H ++
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQELDD----------LTVDLDHQRQ--------- 1441
Query: 123 TGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQT---ALTR- 178
VA+ + + KK L+AE + R + +R + RE +T +L R
Sbjct: 1442 ----------VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 179 ----LSAKGATDAGAKPPRAQMGDRALLETPE-----VKALQDRLVATNLKMSDLRNQIQ 229
L AK + K RA M D L+ + + V L+ A ++ ++R Q++
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMED--LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 230 SVKQELRMAQKVLAREVGEDINVQQL-------LSSPGTWRGRAQQILVLQSKVQELEKQ 282
++ EL+ + R ++N+Q + L + +++L+ Q V+ELE +
Sbjct: 1550 ELEDELQATEDAKLRL---EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ--VRELEAE 1604
Query: 283 LGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
L R Q A + + + D + L AQ + + R E + L KL ++ QREL
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARD---EVIKQLRKLQAQMKDYQREL 1661
Query: 343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEK-------GRH----DDELID------ 385
EE + + + +++K ++K+L++++ L E+ RH DEL D
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 386 ----ALMDQLKQLQEILGSL--SLQEE------------KTRVSQHHLDQQLNSE---AQ 424
AL+D+ ++L+ + L L+EE KT + L+ +L +E AQ
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 425 RSNSLVAQLQAMVAEREAKVRQLE 448
+S++ QL+ E +AK+++LE
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELE 1805
Score = 73.6 bits (179), Expect = 6e-13
Identities = 148/754 (19%), Positives = 297/754 (39%), Gaps = 88/754 (11%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
+E +N + K + + L++Q++++ L+ E ++ + LL
Sbjct: 933 EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL-LE 991
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ NSK EK+++ED I ++L E ++ L K+ +++ I L+++++++
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE---- 1047
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL-------ERELQTAL 176
EL K R L E+ + ++ +L +I EL E ELQ AL
Sbjct: 1048 -----------KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096
Query: 177 TRLSAKGATDAGA-KPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQEL 235
R + A K R A L+ R A K DL +++++K EL
Sbjct: 1097 ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK-RDLSEELEALKTEL 1155
Query: 236 R------MAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQ---SKVQELEKQLGQA 286
AQ+ L + +++ + T AQ + Q + ++EL +QL QA
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215
Query: 287 RSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLE----------------- 329
+ A ++ + D ++L+ + K L ++++ K++ L+
Sbjct: 1216 KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 330 -KLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALM 388
+LA + LQ EL+ + E + + + +L+SQ+ E + + L
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 389 DQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
+++QL+E SL Q+E+ ++ +L++Q V LQ+ +A+ + KV
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQ-----------VLALQSQLADTKKKVDDDL 1384
Query: 449 MEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTS 508
I L + E S R A + + D L R V S
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 509 LGHTLVESALTRPSLPSPHRT-SPRFSDSPEQKGWQAQVSEIKALWQAAEVE-----RDR 562
L + L + ++ S R+++ ++ +A+ E KAL A +E ++
Sbjct: 1445 ---NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 563 LTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRT 622
L+ +E+ S + + + E LEQ +E++R + + +A
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 623 KTGLPTSN-----------NRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEEN 671
K L + + EKK Q+ ++ E + E LA+ ++
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 672 -----EMLKAALGSALRGKEEDFRMYHEILGQVK 700
+ L+A + +A + ++E + ++ Q+K
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Score = 73.2 bits (178), Expect = 8e-13
Identities = 159/807 (19%), Positives = 317/807 (39%), Gaps = 125/807 (15%)
Query: 20 EMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHA-------------GEPN 66
+ Q L+ Q+ KK E+ +R DD E L ++ L ++ E
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDD--ETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 67 SKNSFEK--RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
S+N EK R L +E+E L+ EL +T+D +L +R+ E+ LKK +EE+
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 125 TAGVAGDVVATKIVELSKK-------NRLLMAESEGAKTRVKQLTNRIQELE-------- 169
AT + ELS++ L +G +T K+L ++ L+
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 170 --RELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKM----SD 223
++L + L AK + + A+ + E V L + +K +
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 224 LRNQIQ--------SVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSK 275
L +Q+Q +Q+L ++ ++ E ++ +Q + +Q+L LQS+
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 276 VQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQ-EKNLLRIRSLEREK---QEGLEKL 331
+ + +K++ + + D LS + E+ L LE+ K Q+ L+ L
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 332 ASERD---VLQRELEELKKKFEGMRSRNKLLSS--------------EMKTLKSQMGTLV 374
+ D + LE+ +KKF+ + + K +S+ E +T + +
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 375 EKGRHDDELIDALMDQLK------------------QLQEILGSLSLQEEKTRVSQHHLD 416
E+ E + QL+ +L++ +L Q E+ R L+
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 417 QQLNSEAQRSNSLVAQLQAMVA--EREAKVR-QLEMEIGQLNVHYLR--NKGVGEGSSGR 471
+L + L +QAM A ER+ + R + E +L + +R + + R
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 472 EVSPAYTQFLE------DPGLTKSPASAGDHVGRLGSSRS-VTSLGHTLVESALTRPSLP 524
++ A + +E + + + + + + +L ++ + L E+ +R +
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 525 SPHRTSPRFSDSPEQKGWQAQ--VSEIKALWQAAEVERDRLTEFVT-------VLQKRVE 575
+ + S + S E + Q Q ++ + + AE ERD L + +T L
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732
Query: 576 ESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
+++ + E +L+EE+ +L K L+ +A + AA R+ + N R
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA-ELAAERS-AAQKSDNARQQL 1790
Query: 636 TGSEKKDPSFAQLSDVPVESQ-------MEELTTRLAIQVEENEMLKAALGSALRGKEED 688
K+ + Q + V+S+ +E +L Q+E+ +AA +R E+
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK- 1849
Query: 689 FRMYHEILGQVKSVFLQALRQQKTGKQ 715
++K +F+Q +++ Q
Sbjct: 1850 ---------KLKEIFMQVEDERRHADQ 1867
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/452 (20%), Positives = 187/452 (41%), Gaps = 56/452 (12%)
Query: 24 KRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHL 83
+ L++ +E K E E K D E+ + D + G+ + KR LE ++E +
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDV-----GKNVHELEKSKRALEQQVEEM 1544
Query: 84 RNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELS-- 141
R +L E DE + ++ +K + E D ++ ++ EL
Sbjct: 1545 RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 142 ----KKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMG 197
+K R L S+ K++ +++LE +++ A A+ + +AQM
Sbjct: 1605 LEDERKQRALAVASK------KKMEIDLKDLEAQIEAAN---KARDEVIKQLRKLQAQMK 1655
Query: 198 DRALLETPEVKALQDRLVA----TNLKMSDLRNQIQSVKQELRMAQKVLAR-EVGEDINV 252
D E E +A +D + A + K+ L +I +++EL +++ E D
Sbjct: 1656 DYQR-ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 253 QQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARS---------QSAGTASDELSVYPD 303
++ +S + L++++ +LE++L + +S + D L+
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 304 PRKLSAQEKNLLRIRSLEREKQEGLEKL----------------ASERDVLQRELEELKK 347
+ +AQ+ + R + LER+ +E KL A E + Q E E+L++
Sbjct: 1775 AERSAAQKSDNAR-QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE-EQLEQ 1832
Query: 348 KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD---ELIDALMDQLKQLQEILGSLSLQ 404
+ + + NKL+ K LK + ++ RH D E ++ ++KQL+ L +
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 405 EEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAM 436
+ S+ L ++L+ + + L ++ +
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Score = 58.2 bits (139), Expect = 3e-08
Identities = 91/391 (23%), Positives = 169/391 (43%), Gaps = 38/391 (9%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +AM+ + LQ + E+ EK+ L + + E LE L
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
A K + + LE +IE E + + +L +K+ E++ + +E F
Sbjct: 1615 -AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI-F 1672
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
A + + + +I++L ++ +A SE A+ +Q + EL E+ + + S
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEE----LASSERARRHAEQERD---ELADEITNSASGKS 1725
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QSVKQELRM 237
A + AQ+ + E ++ L DR T L++ L ++ +S Q+
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 238 AQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT---- 293
A++ L R+ E Q L + +A I L++K+ +LE+QL Q + A
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKAT-ISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 294 ------ASDELSVYPDPRKLSAQ-----EKNLLRIRSLEREKQEGLEKLA---SERDVLQ 339
+ D R+ + Q EK R++ L+R+ +E E+ + R LQ
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 340 RELEELKKKFEGMRSRNKLLSSEMKTLKSQM 370
REL++ + EG LS E+ TLK+++
Sbjct: 1905 RELDDATEANEG-------LSREVSTLKNRL 1928
Score = 38.1 bits (87), Expect = 0.029
Identities = 91/418 (21%), Positives = 161/418 (38%), Gaps = 94/418 (22%)
Query: 312 KNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKS 368
K LL++ E E K E L K+ ++ ++ ELEE+++K ++ L E L
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK-------HQQLLEEKNILAE 894
Query: 369 QMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNS 428
Q+ E +E+ L + ++L+EIL H L+ ++ E +R+
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEIL--------------HDLESRVEEEEERNQI 940
Query: 429 LVAQLQAMVAE------------------------REAKVRQLEMEIGQL---NVHYLRN 461
L + + M A EAK++++E EI L N +++
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 462 KGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRP 521
K + E ++ +Q E+ K+ A R ++ L L + TR
Sbjct: 1001 KKLMED----RIAECSSQLAEEEEKAKNLAKI-----RNKQEVMISDLEERLKKEEKTRQ 1051
Query: 522 SLPSPHR-TSPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNS 579
L R +D +Q QAQ+ E+K Q A+ E + LQ + +
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKL--QLAKKEEE--------LQGALARGDD 1101
Query: 580 KLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSE 639
+ L L+ R L+ + +++ + AS+ A + K L SE
Sbjct: 1102 ETLHKNNALKVVRE----LQAQIAELQEDFESEKASRNKAEKQKRDL-----------SE 1146
Query: 640 KKDPSFAQLSD-VPVESQMEELTTRLAIQVEENEMLKAALGSALRGKE---EDFRMYH 693
+ + +L D + + +EL T+ +V E LK AL + E +D R H
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAE---LKKALEEETKNHEAQIQDMRQRH 1201
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 76.6 bits (187), Expect = 7e-14
Identities = 128/573 (22%), Positives = 222/573 (38%), Gaps = 93/573 (16%)
Query: 73 KRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDV 132
K+ L DE + R+EL + EN KLL E+D +I ++++I DR A A +
Sbjct: 220 KKQLADERSN-RDELELELAENR---KLLTEKDAQIAMMQQRI--DRLALLNEKQAASPL 273
Query: 133 VATKIVELSKKNRLL-------MAESEGAKTRVKQLTNRIQELERE-------------- 171
++ EL KN L + + + KT Q+ +I +L E
Sbjct: 274 EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASH 333
Query: 172 ---LQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI 228
LQ AL L T+ +K + + +A LE ALQD+ K L+ ++
Sbjct: 334 LQQLQDALNEL-----TEEHSKATQEWLEKQAQLEKELSAALQDKKCLEE-KNEILQGKL 387
Query: 229 QSVKQELRMAQKVLAREVGEDI-NVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR 287
+++ L Q +E GE + +V QL + A LQ++V+ LE + GQ
Sbjct: 388 SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ-- 445
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK 347
QE LL R E+++ L L ++ L + K+
Sbjct: 446 ----------------------QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKE 483
Query: 348 KFE-GMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEE 406
+ E ++ L++++ +L S++ TL + D+ + L Q K+ Q L Q+E
Sbjct: 484 ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Query: 407 KTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGE 466
+ H +QL+S ++ + + VAE++ R Q + L
Sbjct: 544 QASQGLRHQVEQLSSSLKQKEQQLKE----VAEKQEATR-------QDHAQQLATAAEER 592
Query: 467 GSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSP 526
+S RE D L + A + +L + + + +SA T S+
Sbjct: 593 EASLRE---------RDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT--SVTQA 641
Query: 527 HRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESER 586
R S +V E++A + A E+ V L+ ++ K E ER
Sbjct: 642 QREKAELS---------RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 587 KLQEERHRTVVLEQHLEKIRLEPGKASASQRAA 619
QE+ L+ E +++ G +R A
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
Score = 62.4 bits (150), Expect = 1e-09
Identities = 139/716 (19%), Positives = 280/716 (39%), Gaps = 105/716 (14%)
Query: 10 TLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKN 69
TL+ Q +A Q ++H+ +++ ++KE LK A+ QE + HA +
Sbjct: 538 TLQQQEQASQGLRHQ-VEQLSSSLKQKEQQLKEVAEKQEATRQD-------HAQQ----- 584
Query: 70 SFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVA 129
L E LRE +L L KE+ +++ L+++++ A A
Sbjct: 585 ------LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ--------VANEA 630
Query: 130 GDVVATKIV-------ELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAK 182
D T + ELS+K L A E A+ + ++ ELE +L++ + + K
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 183 GATDAGAKPPRAQMGDRALLETPEVK-------------ALQDRLVATNLKMSDLRNQIQ 229
+ Q+ +AL E+ +V AL+++ + ++ R+ ++
Sbjct: 691 ERVAQEKDQLQEQL--QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Query: 230 SVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
K+E + ++ A G + +QQL G A Q ++ + L ++L +A +
Sbjct: 749 QHKRERKELEEERAGRKGLEARLQQL--------GEAHQ-----AETEVLRRELAEAMAA 795
Query: 290 SAGTASD------ELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELE 343
S+ E++ + + + S QE+ QE L L E + ++EL+
Sbjct: 796 QHTAESECEQLVKEVAAWRERYEDSQQEE-----AQYGAMFQEQLMTLKEECEKARQELQ 850
Query: 344 ELKKKFEGMRSRNKLLSS----EMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILG 399
E K+K G+ S ++L S E+ L + + +++ + + L D L LQE +
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMA 910
Query: 400 SLSLQ------------EEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQL 447
+ S + E++ S+ + + + ++ L Q +A ++ +
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970
Query: 448 EMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVT 507
E E Q+ R + S G++ Q E LT+ A + ++R+
Sbjct: 971 EREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL 1030
Query: 508 SLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFV 567
+ +++AL + E++G ++++++ L A E + L + V
Sbjct: 1031 EM---RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
Query: 568 TVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLP 627
L++++ + + E RT LE +R E K + L
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
Query: 628 TSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALR 683
S + +E+ +S +E L +L + +E ++AL SA R
Sbjct: 1148 RSLEAERASRAER-------------DSALETLQGQLEEKAQELGHSQSALASAQR 1190
Score = 61.2 bits (147), Expect = 3e-09
Identities = 146/735 (19%), Positives = 289/735 (39%), Gaps = 95/735 (12%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E N L A+ E Q ++ +++ +++RE + R Q + + L
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 65 PNSKNS--FEKRVLEDEIEHLRNELRETVDENGRL-------YKLLKERDFEIKHLKKKI 115
N+ N E L++ + H E E +L K L+E +K LK+++
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Query: 116 EEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTA 175
+ +G + A + K L AE + + ++ + LER L+
Sbjct: 1095 AKKEKEHASGSGAQSEA-AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEA- 1152
Query: 176 LTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQ--SVKQ 233
+++ D+ + + Q+ ++A E+ Q L + +++ R ++Q S +
Sbjct: 1153 --ERASRAERDSALETLQGQLEEKA----QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT 293
+ AQ R+ E N L+SS L+ +V L +Q+ + +S
Sbjct: 1207 DEWKAQVARGRQEAERKN--SLISS-------------LEEEVSILNRQVLEKEGESKEL 1251
Query: 294 ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMR 353
++ +KL R+R L+ E + A L+ E++ L+++ E R
Sbjct: 1252 KRLVMAESEKSQKLEE------RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
Query: 354 SRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTR---- 409
++ L E L SQ E G+ + A ++ Q ++ L +L L+ T+
Sbjct: 1306 VASENLRQE---LTSQAERAEELGQE----LKAWQEKFFQKEQALSTLQLEHTSTQALVS 1358
Query: 410 --VSQHHLDQQLNSEA----QRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKG 463
+ HL QQL +E +R + Q + A++ + + E+G+L LR K
Sbjct: 1359 ELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIP--LRQKV 1416
Query: 464 VGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSL 523
+ + +++ + E + K R R+ +LG +E L +
Sbjct: 1417 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA--NLGRQFLEVELDQARE 1474
Query: 524 PSPHRTSPRFSDSPE-----QKGWQAQVSEIKAL---WQAAEV-----------ERDRLT 564
+ +D+ Q+ Q+ E++ + ++ A+V ER +LT
Sbjct: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534
Query: 565 EFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKT 624
V L+ E ++ E +KL + + V +Q L+ ++ + G+ SQ+ A R +
Sbjct: 1535 AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE---SQQEAQRLQA 1591
Query: 625 GLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGS--AL 682
L N S+K+ + + QME+ T + ++N+ L+ L S L
Sbjct: 1592 QL----NELQAQLSQKEQAA------EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641
Query: 683 RGKEEDFRMYHEILG 697
+ + ++ R E LG
Sbjct: 1642 QKENKELRAEAERLG 1656
Score = 60.1 bits (144), Expect = 7e-09
Identities = 100/464 (21%), Positives = 194/464 (41%), Gaps = 64/464 (13%)
Query: 18 MQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLE 77
++ + K ++Q RE D Q E LE G E +
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978
Query: 78 DEIEHLRNELRETV----DENGR----LYKLLKER---------------DFEIKHLKKK 114
+E+E LR L E+ +E G+ + +L +ER + E++ L+
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNA 1037
Query: 115 IEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQT 174
+ E R F + +A + E K++ L ++K+L +++ ++L+
Sbjct: 1038 LNEQRVEFA----TLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL-EELRQTVKQLKE 1092
Query: 175 ALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQE 234
L + + A+ +GA+ ++ R P+++AL+ ++S L Q Q +++
Sbjct: 1093 QLAKKEKEHASGSGAQ---SEAAGRTEPTGPKLEALR-------AEVSKLEQQCQKQQEQ 1142
Query: 235 LRMAQKVLAREVGEDINVQQLLSS-PGTWRGRAQQILVLQSKVQELEKQLGQARS--QSA 291
++ L E L + G +AQ++ QS + +++L R+ Q
Sbjct: 1143 ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
Query: 292 GTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELE--ELKKKF 349
A DE + A+ KN L I SLE E R VL++E E ELK+
Sbjct: 1203 SKAEDEWKAQVARGRQEAERKNSL-ISSLEEEVS------ILNRQVLEKEGESKELKRLV 1255
Query: 350 EGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTR 409
+++ L ++ L+++ + + E AL ++++ L+E + EK R
Sbjct: 1256 MAESEKSQKLEERLRLLQAETASNSARAA---ERSSALREEVQSLRE-------EAEKQR 1305
Query: 410 VSQHHLDQQLNSEAQRSNSLVAQLQA---MVAEREAKVRQLEME 450
V+ +L Q+L S+A+R+ L +L+A ++E + L++E
Sbjct: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLE 1349
Score = 37.0 bits (84), Expect = 0.064
Identities = 71/324 (21%), Positives = 131/324 (40%), Gaps = 33/324 (10%)
Query: 84 RNELRETVDENGRLYKLLKERDFEIKHL----KKKIEEDRFAFTGTAGVAGDVVATKIVE 139
R EL ++ G L L E+ L +K E++R A A A A ++
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKAS--YAEQLSM 1439
Query: 140 LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTR-LSAKGATDAGAKPPRAQMGD 198
L K + LL E+ G R Q LE EL A + + A A A+ A++
Sbjct: 1440 LKKAHGLLAEENRGLGERANLGR---QFLEVELDQAREKYVQELAAVRADAETRLAEVQR 1496
Query: 199 RALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSS 258
A E++ + + +K+ + R + Q +Q+L + L EV + +Q+
Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL--EVFQREQTKQVEEL 1554
Query: 259 PGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIR 318
Q V Q K++ ++ Q G+++ ++ ++L AQ L
Sbjct: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEA--------------QRLQAQLNELQAQL 1600
Query: 319 SLEREKQEG----LEKLASERDVLQR---ELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 371
S + + E +EK + D ++ EL+E + E ++ NK L +E + L ++
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ 1660
Query: 372 TLVEKGRHDDELIDALMDQLKQLQ 395
K + ++ L Q++ L+
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLE 1684
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 76.3 bits (186), Expect = 9e-14
Identities = 130/677 (19%), Positives = 265/677 (39%), Gaps = 101/677 (14%)
Query: 22 QHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIE 81
+H+R K++ R+ ++ R + Q++ L D S+ E + E++ E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDE-SIKKLLEMLQSKGLSAKATEEDHE 331
Query: 82 HLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELS 141
R L E L LL++++ E L++++ RF S
Sbjct: 332 RTRR-LAEAEMHVHHLESLLEQKEKENSMLREEMHR-RFENAPD---------------S 374
Query: 142 KKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRAL 201
K + L E +++ + +++LE E+Q L + GA +
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQM----LKSNGALSTEEREE--------- 421
Query: 202 LETPEVKALQDRLVATNLKMSDLRNQIQSVK---QELRMAQKVLAREVGEDINVQQLLSS 258
E +++ + K+ L+ ++ S + +EL+ L E+G+ V+Q LS
Sbjct: 422 -EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ---VKQELSR 477
Query: 259 PGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIR 318
T ++L LQ+K++ L Q ++ Q + L+ + E + LR+R
Sbjct: 478 KDT------ELLALQTKLETLTNQFSDSK-QHIEVLKESLTAKEQRAAILQTEVDALRLR 530
Query: 319 SLERE-----KQEGLEKLASER--------------DVLQRELEELKKKFEGMRSRNKLL 359
E+E K + ++ +A E+ DV +R++ L+KK E ++ + +
Sbjct: 531 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 590
Query: 360 SSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQL 419
+M +LK ++ +L + D + L + L + + + L Q ++ +
Sbjct: 591 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY 650
Query: 420 NSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQ 479
+ + V+ LQ ++E+EA + L+ L + G+ + S + + A Q
Sbjct: 651 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL-----ASSGLKKDSRLKTLEIALEQ 705
Query: 480 FLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQ 539
E+ +S E+AL R SP SD +
Sbjct: 706 KKEECLKMESQLKKAH-------------------EAALEA-------RASPEMSDRIQH 739
Query: 540 KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLE 599
+ +++ K A+ E DRL E + ++ + + K+ E ER+++++ + L+
Sbjct: 740 L--EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK 797
Query: 600 QHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEE 659
K ++E K++ A R + L S+ + + KKD +L + ES
Sbjct: 798 ---HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRIEELEEALRESVQIT 853
Query: 660 LTTRLAIQVEENEMLKA 676
+ + EE+ A
Sbjct: 854 AEREMVLAQEESARTNA 870
Score = 45.1 bits (105), Expect = 2e-04
Identities = 82/475 (17%), Positives = 188/475 (39%), Gaps = 78/475 (16%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
++ + LRL+ + + M +K+ KQ++ E++ + D ++ L+V +
Sbjct: 521 QTEVDALRLRLEEKETMLNKKT-KQIQDMAEEKGTQAGEIHDLKDMLDVKER-------- 571
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
+ VL+ +IE+L+ +LR+ ++ ++ LK++++ + T
Sbjct: 572 -------KVNVLQKKIENLQEQLRD--------------KEKQMSSLKERVKSLQADTTN 610
Query: 125 TAGVAGDVVATKIVE-LSKKNRLL--MAESEGAKTRVKQ-----LTNRIQELERELQTAL 176
T D T + E L++K R + + E R KQ +++L+ ++
Sbjct: 611 T-----DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ 665
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATN---LKMSDLRNQIQSVKQ 233
LS K A+ K + + L + +K L+ L LKM +
Sbjct: 666 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAAL 725
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVL-----------QSKVQELEKQ 282
E R + ++ R + + + + ++L + K+ ELE+Q
Sbjct: 726 EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQ 785
Query: 283 LGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASE-RDVLQRE 341
+ + A E ++K ++ R +++ L + + +D L+++
Sbjct: 786 VKDQNKKVANLKHKE----------QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK 835
Query: 342 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL 401
+ +++ E +R ++ + L + + +EL+ A+ ++L+ + L
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
Query: 402 SLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQ-------AMVAEREAKVRQLEM 449
S ++ + HL N A+R L L+ A ++E++A + LE+
Sbjct: 896 SSTQQSLAEKETHL---TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLEL 947
Score = 38.5 bits (88), Expect = 0.022
Identities = 51/229 (22%), Positives = 95/229 (41%), Gaps = 25/229 (10%)
Query: 26 LQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEK-----RVLEDEI 80
L++Q++ + +K +LK + +Q E + + L E N +S ++ R +D I
Sbjct: 782 LERQVKDQNKKVANLKHK--EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
Query: 81 EHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVEL 140
E L LRE+V +L + + + +K++EE A V ++ + K
Sbjct: 840 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM---EKVKQELESMKAKLS 896
Query: 141 SKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRA 200
S + L E+ R ++ + + LE + + L +S K A + A
Sbjct: 897 STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA-------------NIA 943
Query: 201 LLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGED 249
LLE K VA + D +Q +KQ+ + K++A +D
Sbjct: 944 LLELSSSKKKTQEEVAALKREKD--RLVQQLKQQTQNRMKLMADNYEDD 990
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 75.5 bits (184), Expect = 2e-13
Identities = 169/750 (22%), Positives = 294/750 (39%), Gaps = 140/750 (18%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKR------EKELSLKSRADDQEEPL------- 51
E SQ L Q + E + RLQ+ +E+++ KEL R DQ E L
Sbjct: 386 EPSQVGLERQLEEKTE-ECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQ 444
Query: 52 --EVSDGLSLLHAGEPNS----KNSFEKRVLEDEI--------EHLRNELRETVDENGRL 97
E+ + L + EP K+ E R L +E+ E LR RE G L
Sbjct: 445 VMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL 504
Query: 98 YKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMA-------- 149
+ + RD E++H++++ + D + A A E K + L+
Sbjct: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEET 564
Query: 150 ----------------ESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPR 193
+ K + QL +E+E EL + L + + R
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRE------LEQAR 618
Query: 194 AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQ 253
A GD T +V+ L+ L+ T ++ +L Q+ +Q +A + RE+ + + V
Sbjct: 619 ASAGD-----TRQVEVLKKELLRTQEELKEL----QAERQSQEVAGRHRDRELEKQLAVL 669
Query: 254 QLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKL------ 307
++ + G R +Q L LQ +Q+L + +A S++ A E +V R
Sbjct: 670 RVEADRG--RELEEQNLQLQKTLQQLRQDCEEA-SKAKMVAEAEATVLGQRRAAVETTLR 726
Query: 308 SAQEKN---LLRIRSLEREKQE-------GLEKLASERDVLQR---ELEELKKKFEGMRS 354
QE+N RI LE++ +E G A RD LQR E ++L++ +
Sbjct: 727 ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE 786
Query: 355 RNKLLSSEMKTLKSQMGT----LVEKGRHDDELIDALMDQLKQLQEIL--GSLSLQEEKT 408
L++ + L++++ L G+ L AL ++ KQ +E+L G L+E+K
Sbjct: 787 EEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ-REVLRRGKAELEEQKR 845
Query: 409 RVSQ--HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGE 466
+ + L+++L + S + QLQA + + + K R+ V + +
Sbjct: 846 LLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR--------EVADAQRQAKDW 897
Query: 467 GSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSP 526
S + S ++ ++ + A + R L L+ L +
Sbjct: 898 ASEAEKTSGGLSRLQDEIQRLRQALQASQ------AERDTARLDKELLAQRLQGLEQEAE 951
Query: 527 HRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESER 586
++ + + + KG + +VS + E E D V +L RV ++ +
Sbjct: 952 NKKRSQDDRARQLKGLEEKVSRL-------ETELDEEKNTVELLTDRVNRGRDQVDQLRT 1004
Query: 587 KLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFA 646
+L +ER LE +KI LE R KT L +S G +K S +
Sbjct: 1005 ELMQERSARQDLE--CDKISLE--------RQNKDLKTRLASSE------GFQKPSASLS 1048
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKA 676
QL ESQ + L RL + E +L++
Sbjct: 1049 QL-----ESQNQLLQERLQAEEREKTVLQS 1073
Score = 57.8 bits (138), Expect = 3e-08
Identities = 86/414 (20%), Positives = 187/414 (45%), Gaps = 38/414 (9%)
Query: 3 ADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHA 62
A + + +L +A+ E + + Q+ + + +++ +L +++ + EV L
Sbjct: 783 ASQEEEGSLAAAKRAL-EARLEEAQRGLARLGQEQQTLNRALEEEGKQREV------LRR 835
Query: 63 GEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKER--DFEIKHLKKKIEEDRF 120
G+ + +KR+L+ ++ L EL + +++ + + L+ + D++ K ++ + R
Sbjct: 836 GKAELEE--QKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893
Query: 121 A---FTGTAGVAGDV--VATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTA 175
A + +G + + +I L + + AE + A+ + L R+Q LE+E +
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
Query: 176 LTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QSVK 232
+ G + +++ E V+ L DR+ ++ LR ++ +S +
Sbjct: 954 KRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR 1013
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQ--------QILVLQSKVQELEKQLG 284
Q+L + L R+ +D+ + L SS G + A Q+L + + +E EK +
Sbjct: 1014 QDLECDKISLERQ-NKDLKTR-LASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVL 1071
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKN---LLRIRSLER---EKQEGLEKLASERDVL 338
Q+ ++ ELS+ + + ++ LR+++L+R E +E +E+L R
Sbjct: 1072 QSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKA 1131
Query: 339 QRELEELKKKFEGMRSRNKLLSSEMKTLKSQM---GTLVEKGRHDDELIDALMD 389
QRE+EE + E +++R K L + S+ L +G DE D++ D
Sbjct: 1132 QREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYD 1185
Score = 39.3 bits (90), Expect = 0.013
Identities = 76/345 (22%), Positives = 145/345 (42%), Gaps = 44/345 (12%)
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
L KV+EL+++L + + ++ + R+L + + R+ QE LE+
Sbjct: 364 LTRKVEELQRKLDEEVKKRQKLEPSQVGL---ERQLEEKTEECSRL-------QELLERR 413
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQL 391
E +EL+ +K+ + L +++ L++++ + + L+ L++
Sbjct: 414 KGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 473
Query: 392 KQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEI 451
+ L+E+L E K RV ++QL + +L L+ VA R+ +V + +
Sbjct: 474 ELLEEVL------EGKQRV-----EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY 522
Query: 452 GQLNVHYLRNKGVGEGSSGREVSPAYTQFLED--PGLTKSPASAGDHVGRLGS--SRSVT 507
Q + LR + + + + V A Q + GL + + G S ++
Sbjct: 523 -QRDTEQLR-RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE 580
Query: 508 SLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFV 567
L T E R + E+ G + +V + + L QA D T V
Sbjct: 581 DLRATKQELLQLRMEK----------EEMEEELGEKIEVLQ-RELEQARASAGD--TRQV 627
Query: 568 TVLQKRVEESNSKL--LESERKLQE--ERHRTVVLEQHLEKIRLE 608
VL+K + + +L L++ER+ QE RHR LE+ L +R+E
Sbjct: 628 EVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Score = 36.6 bits (83), Expect = 0.083
Identities = 78/346 (22%), Positives = 137/346 (39%), Gaps = 39/346 (11%)
Query: 288 SQSAGTASDELSVYPDPRKLSAQEKNLLRIRS---LEREKQEG----------------L 328
S+S T L + +PR+ SAQ+ +L+ +S L R++QE L
Sbjct: 264 SRSRQTQDWVLQSFEEPRR-SAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGIL 322
Query: 329 EKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALM 388
+ +SE + R L E M+ + S K + Q G L K +D +
Sbjct: 323 REGSSESETSVRRKVSLV--LEKMQPLVMVSSGSTKAVAGQ-GELTRKVEELQRKLDEEV 379
Query: 389 DQLKQLQEILGSLSLQ-EEKTRVSQH--HLDQQLNSEAQRSNSLVAQLQAMVAEREAKVR 445
+ ++L+ L Q EEKT L ++ EAQ+SN + ++ ++ + E
Sbjct: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
Query: 446 QLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVG---RLGS 502
LE ++ +L + K V +EV LE L + V RL
Sbjct: 440 GLETQVMELQN---KLKHVQGPEPAKEV--LLKDLLETRELLEEVLEGKQRVEEQLRL-R 493
Query: 503 SRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDR 562
R +T+L L E +R R + ++ Q + L E ER +
Sbjct: 494 ERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL----EAERQK 549
Query: 563 LTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE 608
++ V LQ+ +EE++ + + Q+ + +Q L ++R+E
Sbjct: 550 MSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRME 595
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 74.7 bits (182), Expect = 3e-13
Identities = 116/506 (22%), Positives = 225/506 (44%), Gaps = 61/506 (12%)
Query: 6 SSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG-- 63
+S LR + +A ++ Q LQ+ E + +L LK R ++ E LE++ + HA
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADL-LKGRVENLERELEIAR-TNQEHAALE 2358
Query: 64 EPNSKNSFEK------------RVLEDEIEHLRNELRETVDENGRLYKLLKERDF---EI 108
NSK E R LE ++ +R+E +E + + + E +
Sbjct: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
Query: 109 KHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL 168
+++ ++ E+++ + A +++ T++ EL+++ L + E K + + L+++++ L
Sbjct: 2419 ENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL 2478
Query: 169 ERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI 228
E E L +G +A Q L++ EV+ + +L + ++S L+NQI
Sbjct: 2479 ELEKAQLL-----QGLDEAKNNYIVLQSSVNGLIQ--EVEDGKQKLEKKDEEISRLKNQI 2531
Query: 229 QSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARS 288
Q +Q + K+ E + +Q L Q+I VLQSK L+ L +S
Sbjct: 2532 QDQEQ---LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQS 2588
Query: 289 QSAG-------TASDELSVYPDPRKLSAQEKNLLR-IRSLEREKQEGLEKLASERDVLQR 340
T D++S K++A+E L R + + ++ E E+L+ E++ L
Sbjct: 2589 SYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG 2648
Query: 341 ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTL----VEK-GRHDDELID---------- 385
EL+ L ++ + + + K L+ E LK + + VEK G+ +E+ +
Sbjct: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
Query: 386 ----ALMDQLKQ----LQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV 437
L+D KQ +Q L+ +EE + +D +S+ + +NSL A Q +
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768
Query: 438 AEREAKVRQLEMEIGQLNVHYLRNKG 463
++ K+ L+ + QL R +G
Sbjct: 2769 ELKKTKMDNLKY-VNQLKKENERAQG 2793
Score = 71.6 bits (174), Expect = 2e-12
Identities = 110/463 (23%), Positives = 206/463 (44%), Gaps = 52/463 (11%)
Query: 16 KAMQEMQHKRLQKQMEKKREKELSLKSRADDQE-EPLEVSDGL--SLLHAGE---PNSKN 69
K E Q +L K+ E ++ SL++R + + E L VS L +L+ GE S
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2110
Query: 70 SFEKRVLEDEIEHLRNELRETVDENGRLY--KLLKERDFEIKHLKKKIEEDRFAFTGTAG 127
E L IE LR +R DE +L+ + LKER+ E LK K+E
Sbjct: 2111 QEEVHQLRRGIEKLR--VRIEADEKKQLHIAEKLKERERENDSLKDKVEN---------- 2158
Query: 128 VAGDVVATKIVELSKKNR-LLMAESEGAKTRVKQLTNRIQELERELQT-ALTRLSAKGAT 185
+ +++S++N+ L++ ++E +K V+ L +I+E+ R L+ L ++ +
Sbjct: 2159 ------LERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 186 DAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQ-SVKQELRMAQKVLAR 244
+ K + + G + L D+L+++ + + + Q + +K+E + A ++L
Sbjct: 2213 ENLTKQIQEKQGQLSEL---------DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN 2263
Query: 245 EVGE-DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPD 303
++ E + V L + Q + + +L + + R++ +L V
Sbjct: 2264 QLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ 2323
Query: 304 PRKLSAQEKNLL--RIRSLEREKQ---EGLEKLASERDVLQRELEELKKKFEGMRSRNKL 358
++ S +LL R+ +LERE + E A E + + E+E LK K EGM +
Sbjct: 2324 LKE-SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382
Query: 359 LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQ----EEKTRVSQHH 414
L ++ T++S+ L + + + E I L + IL + +EK+ +
Sbjct: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM 2442
Query: 415 LDQQLNSEAQRSNSLVAQLQAMVAERE---AKVRQLEMEIGQL 454
L QL +R +L +A A+ + ++V LE+E QL
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL 2485
Score = 63.9 bits (154), Expect = 5e-10
Identities = 151/750 (20%), Positives = 308/750 (41%), Gaps = 86/750 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKR---LQKQMEKKREKELSLKSRADDQEEPLEVSDGL 57
M AD+SS+ + + + +R ++ ++ + R ++ S++ A E LEV
Sbjct: 1872 MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE 1931
Query: 58 SLLHAGEPNSKNSFEKRV-LEDEIEHL---RNELRETVDENGRLYKLLKERDFEIKHLKK 113
L E +++N + V LE+E+ + RN+LR +D + L + ++K +
Sbjct: 1932 KLCL--EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 114 KIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQ 173
++E + VA E+ +K LL S +K T+ L+ +LQ
Sbjct: 1990 ELESHQSECLHCIQVAE-------AEVKEKTELLQTLSSDVSELLKDKTH----LQEKLQ 2038
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATN--------------- 218
+ A T + AQ+ L E ++LQ RL ++
Sbjct: 2039 SLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALV 2098
Query: 219 ------LKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVL 272
L++S + ++ +++ + + + + + +++ + L R ++ L
Sbjct: 2099 EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKE------RERENDSL 2152
Query: 273 QSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLR-IRSLEREKQEGLEKL 331
+ KV+ LE++L + D + + L Q + + R ++ E + L L
Sbjct: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD----LVTL 2208
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQL 391
SE++ L ++++E + + + +KLLSS L+ + ++ ++ L +QL
Sbjct: 2209 RSEKENLTKQIQEKQGQLSEL---DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 392 KQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEI 451
K+L E + +L +E + ++ LD + E Q NS + +L+A + E K + ++
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS-IEKLRARLEADEKKQLCVLQQL 2324
Query: 452 GQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRL-----GSSRSV 506
+ H KG E RE+ A T ++ ++ S G+ V L G ++S+
Sbjct: 2325 KESEHHADLLKGRVENLE-RELEIARTN--QEHAALEAENSKGE-VETLKAKIEGMTQSL 2380
Query: 507 TSLGHTLVESALTRPSLPSP-HRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTE 565
L +V + +L + + R S+ + S + + Q E E+ ++ E
Sbjct: 2381 RGLELDVVTIRSEKENLTNELQKEQERISE------LEIINSSFENILQEKEQEKVQMKE 2434
Query: 566 ----FVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPR 621
+ +LQ +++E N ++ + + + L +E + LE + A
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 622 TKTGLPTSNN------RHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLK 675
L +S N EKKD ++L + ++ Q E+L ++L+ QVE L
Sbjct: 2495 NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN-QIQDQ-EQLVSKLS-QVEGEHQLW 2551
Query: 676 AALGSALRGKEEDFRMYHEILGQVKSVFLQ 705
LR + ++L Q K+ LQ
Sbjct: 2552 KEQNLELRNLTVELEQKIQVL-QSKNASLQ 2580
Score = 61.2 bits (147), Expect = 3e-09
Identities = 151/756 (19%), Positives = 315/756 (41%), Gaps = 93/756 (12%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAG 63
D+ +Q L L + + E + + ++ + + + +D+ + S+ +S L
Sbjct: 1695 DKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS--SECISELSFS 1752
Query: 64 EPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
PN+ + +++I +L+ ++ET +EN RL ++++RD +++ L +++E
Sbjct: 1753 GPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE----LD 1808
Query: 124 GTAGVAGDVVATKI---VELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
+ + TKI +EL K L E+ +++ + QEL + ++T+ L+
Sbjct: 1809 SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETS-EGLN 1867
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQE---LRM 237
+ A K R +GD K +R + ++S +R++ S++ E L
Sbjct: 1868 SDLEMHAD-KSSREDIGDNVAKVNDSWK---ERFLDVENELSRIRSEKASIEHEALYLEA 1923
Query: 238 AQKVLARE-----------------VGEDINV-----QQLLSSPGTWRGRAQQILVLQSK 275
+V+ E + E+++V QL T + + L K
Sbjct: 1924 DLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEK 1983
Query: 276 VQELEKQLGQARSQ---SAGTASDELSVYPD-PRKLSAQEKNLLRIRSLEREKQEGLEK- 330
++E ++L +S+ A E+ + + LS+ LL+ ++ +EK + LEK
Sbjct: 1984 MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
Query: 331 ----------LASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTL---KSQMGTLVEKG 377
L ++ L +E E L K+ E +++R L S+ + L K+ LVEKG
Sbjct: 2044 SQALSLTKCELENQIAQLNKEKELLVKESESLQAR--LSESDYEKLNVSKALEAALVEKG 2101
Query: 378 RHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAM- 436
L + +++ QL+ + L ++ E Q H+ ++L + ++SL +++ +
Sbjct: 2102 EFALRL-SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 437 ----VAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREV--SPAYTQFLEDPGLTKSP 490
++E ++ L+ E + V L+ + + E + +V T E LTK
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQ-IEEMARSLKVFELDLVTLRSEKENLTKQI 2219
Query: 491 ASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVS--- 547
+ L + ++S L E + +T+ + ++ +A +
Sbjct: 2220 QEKQGQLSEL--DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG 2277
Query: 548 ---EIKALWQAAE---VERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQH 601
+KA Q+ + E +L + L+ R+E K L ++L+E H +L+
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR 2337
Query: 602 LEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQ------LSDVPVES 655
+E + E A +Q A L N++ + K Q L V + S
Sbjct: 2338 VENLERELEIARTNQEHA-----ALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 656 QMEELTTRLAIQ---VEENEMLKAALGSALRGKEED 688
+ E LT L + + E E++ ++ + L+ KE++
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Score = 60.5 bits (145), Expect = 5e-09
Identities = 110/523 (21%), Positives = 217/523 (41%), Gaps = 86/523 (16%)
Query: 3 ADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHA 62
A ++ + L Q + + E++ +L + +++ + + L+S + + EV DG
Sbjct: 2463 ACKAKEQNLSSQVECL-ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ--EVEDG------ 2513
Query: 63 GEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRL------YKLLKERDFEIKHLKKKIE 116
K EK+ ++EI L+N++++ +L ++L KE++ E+++L ++E
Sbjct: 2514 -----KQKLEKK--DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 117 EDRFAFTGTAGVAGDVVATKIVELSKKN-----RLLMAESEGAKTRVKQLTNRIQELERE 171
+ D + ++++ S KN L + +V ++T + EL+RE
Sbjct: 2567 QKIQVLQSKNASLQDTL--EVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQRE 2624
Query: 172 LQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSV 231
+ + + +G K A G+ LL E+K+ +D+L L+ S+L+ + +
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLA--GELQLL-LEEIKSSKDQLKELTLENSELKKSLDCM 2681
Query: 232 KQELRMAQKVLAREVGE-----------------DINVQ----------QLLSSPGTWRG 264
++ + + E+ E D N Q +L S
Sbjct: 2682 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741
Query: 265 RAQQILVLQSKVQELEKQLG---QARSQSAGTASDELSVYPDPRKLS--AQEKNLLRIRS 319
+ +I +L+S +EL L Q + T D L +K + AQ K L I+S
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS 2801
Query: 320 LEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKL------LSSEMKTLKSQMGTL 373
++ L E+++LQ+EL +L+ E ++ + L++E+K LK TL
Sbjct: 2802 CKQ--------LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE---TL 2850
Query: 374 VEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQL 433
EK + DE +D L ++ L +E HL Q + + R + L+ +
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEK----LEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPV 2906
Query: 434 QAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPA 476
+ + V + + GQ R + G +GR +PA
Sbjct: 2907 VPGPSPIPS-VTEKRLSSGQNKASGKRQRSSGIWENGRGPTPA 2948
Score = 57.4 bits (137), Expect = 5e-08
Identities = 103/454 (22%), Positives = 182/454 (40%), Gaps = 67/454 (14%)
Query: 52 EVSDGLSLLHAGEPNSKNSF----EKRVLEDEIEHLRNELRETVDE------------NG 95
EV+ S L G+ ++ +SF L D+++ ELR ++E G
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
Query: 96 RLYKL------LKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLM- 148
++ K L++ E+ +K + + R T D +TK L +K + L
Sbjct: 311 QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY-DQASTKYTALEQKLKKLTE 369
Query: 149 ---AESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETP 205
+ + A++ L +I+E E+E Q L+R T QM R E
Sbjct: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT---LDQECIQMKARLTQELQ 426
Query: 206 EVKALQDRLVATNLKMSD----LRNQIQSVKQELRMAQKV----------LAREVGEDIN 251
+ K + + L A K++ L N ++ KQ+L A++ L R + E
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 252 VQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQ----ARSQSAGTASDELSVYPDPRKL 307
LL S +A+++ L+++++ +++ L Q A A S E + K+
Sbjct: 487 ENNLLKSHS--EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
Query: 308 SAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLK 367
+ QE +L +LE+ K + L +RD Q + LKK+ + N LS K K
Sbjct: 545 NQQENSL----TLEKLKL-AVADLEKQRDCSQ---DLLKKREHHIEQLNDKLSKTEKESK 596
Query: 368 SQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSN 427
+ + L K + +EL K+ + + + EK + L S+
Sbjct: 597 ALLSALELKKKEYEEL--------KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE 648
Query: 428 SLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRN 461
+ + Q E +VR LEM+ L+V +RN
Sbjct: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVE-IRN 681
Score = 41.2 bits (95), Expect = 0.003
Identities = 119/643 (18%), Positives = 239/643 (37%), Gaps = 82/643 (12%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E+ +N L Q K +H+ ++ E+ +L + ++ L S + +
Sbjct: 1065 ENRKNELE-QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR-----SEMTDNQ 1118
Query: 65 PNSKNSF-----EKRVLEDEIEHLRNELRETVDENGRLYKLLKER----DFEIKHLKKKI 115
NSK+ E L++E ++ E+ + + EN +L K++K + + E + ++ +
Sbjct: 1119 NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178
Query: 116 EEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQE---LEREL 172
+E + K + L N L+ + + +L +E L+ EL
Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
Query: 173 QTALTRLSAKGATD------AGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRN 226
QT L D +G K ++ + E+ Q+ + N
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 227 QIQSVKQ--ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
++ +++ E+ A+K E+ ++N R++ I + +E+ K L
Sbjct: 1299 KLNELEKICEILQAEKY---ELVTELN-----------DSRSECITATRKMAEEVGKLLN 1344
Query: 285 QAR--SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
+ + + +G EL + Q + ++ E L +Q
Sbjct: 1345 EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
Query: 343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLS 402
EL++KF ++S +K+L + + S+M L +D LK +L +
Sbjct: 1405 AELQEKFLSLQSEHKILHDQHCQMSSKMSEL-----------QTYVDSLKAENLVLSTNL 1453
Query: 403 LQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAK-VRQLEMEIGQLNVHYLRN 461
+ V + L + S+S V ++ + ++ R L + G +++ L N
Sbjct: 1454 RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL--LSN 1511
Query: 462 KGVGEGSSGREVSPAYTQFLEDPGLTK--SPASAGDHVGRLGSSRSVTSLGHTLVESALT 519
++ V + L++ LT+ +P++ V L S V
Sbjct: 1512 LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV------------Y 1559
Query: 520 RPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRL----TEFVTVLQKRVE 575
R SL + + E +G EI+ L Q ER L ++++ ++ +
Sbjct: 1560 RQSL-------EKLEEKMESQGIMKN-KEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
Query: 576 ESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRA 618
+ S LE E KL E+ +T L LE RL+ S R+
Sbjct: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRS 1654
Score = 36.2 bits (82), Expect = 0.11
Identities = 99/466 (21%), Positives = 197/466 (42%), Gaps = 57/466 (12%)
Query: 22 QHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKN---SFEKRVLED 78
++++L QME ++E +L+S+ + E L+ + + E N + ++ L
Sbjct: 625 ENEKLLTQMESEKE---NLQSKINHLETCLKTQQ----IKSHEYNERVRTLEMDRENLSV 677
Query: 79 EIEHLRNELR----ETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDV-- 132
EI +L N L E + +L ++ +F + +K+IE + G D+
Sbjct: 678 EIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEH 737
Query: 133 ----VATKIVELSKKNRLLMAESEGAKTRVKQ-----LTNRIQE---LERELQTALTRLS 180
++ +I++ + + L AE E + +K +TN + L + Q A+
Sbjct: 738 KLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 797
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKA-LQDRLVATNLKM-------SDLRNQIQS-- 230
A + G+ P ++P+ A LQ+R+ + + SDL+ Q +
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 231 -----VKQELRMAQKVLAREVGEDIN-VQQLLSSPGTWRGR-AQQILVLQSKVQELEKQL 283
+++ L A+++ V E + +L + A+ + L++K +EL QL
Sbjct: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL--QL 915
Query: 284 GQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELE 343
+ ++ EL + S +E LL +L EK+E ++S + +RE+E
Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS-ETLSLEKKE----MSSIISLNKREIE 970
Query: 344 ELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSL 403
EL ++ ++ N L+ E L + + ++ I L DQ KQ + IL L
Sbjct: 971 ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL----L 1026
Query: 404 QE-EKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
Q E+T + L Q+ + ++++ L L + E + +LE
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
Score = 31.2 bits (69), Expect = 3.5
Identities = 18/76 (23%), Positives = 38/76 (50%), Gaps = 2/76 (2%)
Query: 545 QVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEK 604
++ + K + + E D+LT L+ +EE KL +E+ Q + + L + +E+
Sbjct: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE 483
Query: 605 IRLEPG--KASASQRA 618
++ E K+ + Q+A
Sbjct: 484 MKKENNLLKSHSEQKA 499
Score = 30.4 bits (67), Expect = 6.0
Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 10/102 (9%)
Query: 2 AADESSQNTLRLQFKAMQEMQHKRLQK-----QMEKKREK-----ELSLKSRADDQEEPL 51
++ E N+L+ + ++E++ ++ Q++K+ E+ +L +KS +EE
Sbjct: 2751 SSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKE 2810
Query: 52 EVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDE 93
+ LS L A + K DE+ EL+ET++E
Sbjct: 2811 ILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 74.3 bits (181), Expect = 4e-13
Identities = 136/709 (19%), Positives = 281/709 (39%), Gaps = 105/709 (14%)
Query: 4 DESSQNTL-RLQFKAMQEM-QHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLH 61
DE+S+ T+ + Q++ +QE QH ++ Q +L+ Q + ++ S
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQ---------ALQDELRIQRDLNQLFQQDSSSR 253
Query: 62 AGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFA 121
GEP + E+ + L E E L K L+E + I+ K+ +
Sbjct: 254 TGEP-----CVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN----- 303
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
A D K++E+ + L +E R T R+ E E + + L
Sbjct: 304 -------ARDESIKKLLEMLQSKGLSAKATEEDHER----TRRLAEAEMHVHHLESLLEQ 352
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK- 240
K ++ + + + A ++ + KALQ + + K+S + ++ +++E++M +
Sbjct: 353 KEKENSMLREEMHRRFENAP-DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411
Query: 241 --VLAREVGEDINVQQLLSSPGTWR----GRAQQ--------ILVLQSKVQELEKQLGQA 286
+ E E++ ++ S + G+ +Q +L LQ+K++ L Q +
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471
Query: 287 RSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLERE-----KQEGLEKLASER------ 335
+ Q + L+ + E + LR+R E+E K + ++ +A E+
Sbjct: 472 K-QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 530
Query: 336 --------DVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDAL 387
DV +R++ L+KK E ++ + + +M +LK ++ +L + D + L
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 388 MDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQL 447
+ L + + + L Q ++ + + + V+ LQ ++E+EA + L
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL 650
Query: 448 EMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVT 507
+ L + G+ + S + + A Q E+ +S
Sbjct: 651 KEHASSL-----ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH------------ 693
Query: 508 SLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFV 567
E+AL R SP SD + + +++ K A+ E DRL E +
Sbjct: 694 -------EAALEA-------RASPEMSDRIQHL--EREITRYKDESSKAQAEVDRLLEIL 737
Query: 568 TVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLP 627
++ + + K+ E ER+++++ + L+ K ++E K++ A R + L
Sbjct: 738 KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARRREDNLN 794
Query: 628 TSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKA 676
S+ + + KKD +L + ES + + EE+ A
Sbjct: 795 DSSQQLQDS-LRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842
Score = 45.1 bits (105), Expect = 2e-04
Identities = 82/475 (17%), Positives = 188/475 (39%), Gaps = 78/475 (16%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
++ + LRL+ + + M +K+ KQ++ E++ + D ++ L+V +
Sbjct: 493 QTEVDALRLRLEEKETMLNKKT-KQIQDMAEEKGTQAGEIHDLKDMLDVKER-------- 543
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
+ VL+ +IE+L+ +LR+ ++ ++ LK++++ + T
Sbjct: 544 -------KVNVLQKKIENLQEQLRD--------------KEKQMSSLKERVKSLQADTTN 582
Query: 125 TAGVAGDVVATKIVE-LSKKNRLL--MAESEGAKTRVKQ-----LTNRIQELERELQTAL 176
T D T + E L++K R + + E R KQ +++L+ ++
Sbjct: 583 T-----DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ 637
Query: 177 TRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATN---LKMSDLRNQIQSVKQ 233
LS K A+ K + + L + +K L+ L LKM +
Sbjct: 638 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAAL 697
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVL-----------QSKVQELEKQ 282
E R + ++ R + + + + ++L + K+ ELE+Q
Sbjct: 698 EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQ 757
Query: 283 LGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASE-RDVLQRE 341
+ + A E ++K ++ R +++ L + + +D L+++
Sbjct: 758 VKDQNKKVANLKHKE----------QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK 807
Query: 342 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL 401
+ +++ E +R ++ + L + + +EL+ A+ ++L+ + L
Sbjct: 808 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 867
Query: 402 SLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQ-------AMVAEREAKVRQLEM 449
S ++ + HL N A+R L L+ A ++E++A + LE+
Sbjct: 868 SSTQQSLAEKETHL---TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLEL 919
Score = 38.5 bits (88), Expect = 0.022
Identities = 51/229 (22%), Positives = 95/229 (41%), Gaps = 25/229 (10%)
Query: 26 LQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEK-----RVLEDEI 80
L++Q++ + +K +LK + +Q E + + L E N +S ++ R +D I
Sbjct: 754 LERQVKDQNKKVANLKHK--EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
Query: 81 EHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVEL 140
E L LRE+V +L + + + +K++EE A V ++ + K
Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM---EKVKQELESMKAKLS 868
Query: 141 SKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRA 200
S + L E+ R ++ + + LE + + L +S K A + A
Sbjct: 869 STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA-------------NIA 915
Query: 201 LLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGED 249
LLE K VA + D +Q +KQ+ + K++A +D
Sbjct: 916 LLELSSSKKKTQEEVAALKREKD--RLVQQLKQQTQNRMKLMADNYEDD 962
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.6 bits (179), Expect = 6e-13
Identities = 143/755 (18%), Positives = 286/755 (37%), Gaps = 88/755 (11%)
Query: 20 EMQHKRLQKQMEKKREKELSLKSRADDQ--------EEPLEVSDGLSLLHA---GEPNSK 68
+ Q L+ Q+ KK E+ + +R DD+ ++ E+ +S L E ++
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 69 NSFEK--RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTA 126
N EK R L +E+E L+ EL +T+D +L +R+ E+ LKK ++E+ +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 127 GVAGDVVATKIVELS--------------KKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
A + EL+ K + L E+ ++ L QE+E +
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 173 QTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
+ ++ + + + RA++ D+ EV+++ L K L + S+
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL--------VLQSKVQELEKQLG 284
+L+ Q++L E + +NV L R Q L L+ + L QL
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
++ + AS ++ ++ + +NL + EK +KL ++ LQ+EL++
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQ---QYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 345 L-----------------KKKFEGMRSRNKLLSS--------------EMKTLKSQMGTL 373
L ++KF+ + + K +SS E +T +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 374 VEKGRHDDELIDALMDQLK-QLQEILGS---LSLQEEKTRVSQHHLDQQLNSEAQRSNSL 429
+E+ E ++ LK ++++++ S + + S+ L+ Q+ + L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 430 VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKS 489
+LQ A +AK+R LE+ + L + R+ + + + Q E +
Sbjct: 1552 EDELQ---ATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEI 549
R++ + +E L L + R + + QAQ+ +
Sbjct: 1608 ER----------KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEP 609
+ + A RD + +K+ + + L++ + L + E++ E
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 610 GKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDV-PVESQMEELTTRLAIQV 668
+ + + A K L + E++ A V Q E+L+ LA +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 669 EENEMLKAALGSALRGKEEDFRMYHEILGQVKSVF 703
+ ++A R +E HE+ G VKS F
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Score = 72.8 bits (177), Expect = 1e-12
Identities = 153/765 (20%), Positives = 308/765 (40%), Gaps = 126/765 (16%)
Query: 19 QEMQHKRLQKQMEKKREKELSLKSRADDQE---EPLEVSDGLS----------LLHAGEP 65
+E + ++LQ + +K ++ L L+ + +++E + L++ + +L +
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 66 NSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDF-----------------EI 108
N+K S E+++LE+ I L L E ++ L KL + + E+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 109 KHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTN---RI 165
+ LK+K+E D F +A ++L+KK L A + Q N +I
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1113
Query: 166 QELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLR 225
+ELE + L ++ A A+ + +G+ E++AL+ L T + +
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGE-------ELEALKTELEDTLDSTATQQ 1166
Query: 226 NQIQSVKQELRMAQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
+QE+ + +K L E + VQ++ V+EL +QL
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELTEQLE 1213
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
Q + A ++ ++ + L+ + +R L + KQE + ++ L+ +++E
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQE----VEHKKKKLEAQVQE 1263
Query: 345 LKKK-FEGMRSRNKL------LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEI 397
L+ K +G R+R +L L +E++++ + K + + +L QL+ QE+
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
L +E+TR + ++ +L + NSL QL E EAK + LE I LN+
Sbjct: 1324 L------QEETR-QKLNVSTKLRQLEEERNSLQDQLD---EEMEAK-QNLERHISTLNIQ 1372
Query: 458 YLRNK-----------GVGEGSS--GREVSPAYTQFLE--------DPGLTKSPASAGDH 496
+K + EG +E+ Q+ E + + D
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 497 VGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAA 556
V L + R + S + + L S +++D ++ +A+ E KAL A
Sbjct: 1433 VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 557 EVE-----RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE--- 608
+E ++ L +L+ +E+ S + + + E LE +E+++ +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 609 -PGKASASQRAAPRTKTGLPTSNNR-------HNPTGSEKKDPSFAQLSDVPVESQMEEL 660
+ A++ A R + + + + EK+ QL + E + E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 661 TTRLAIQVEEN-----EMLKAALGSALRGKEEDFRMYHEILGQVK 700
LA ++ + L+ SA++G+EE + ++ Q+K
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Score = 69.7 bits (169), Expect = 9e-12
Identities = 90/393 (22%), Positives = 171/393 (43%), Gaps = 47/393 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +A++ + LQ + E+ EK L+ + + E LE L
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
A K+ LE +++ L + + K L++ ++K ++++E+ R
Sbjct: 1615 AAAA--------KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR- 1665
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAES-------EGAKTRVKQLTNRIQELERELQ 173
+ D + E KK + L A+ A+ KQ +EL EL
Sbjct: 1666 -------ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QS 230
++L+ +A + AQ+ + E ++A+ DR+ + L N++ +S
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 231 VKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-ILVLQSKVQELEKQLGQ-ARS 288
Q+ A++ L R+ E + +L G + + + I L++K+ +LE+Q+ Q AR
Sbjct: 1779 TAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 289 QSAGTAS---------DELSVYPDPRKLSAQ-----EKNLLRIRSLEREKQEGLE---KL 331
+ A T S + L D RK++ Q EK R++ L+R+ +E E ++
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMK 364
+ R LQREL+E + E M L S+++
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 68.2 bits (165), Expect = 3e-11
Identities = 146/724 (20%), Positives = 287/724 (39%), Gaps = 92/724 (12%)
Query: 19 QEMQHKR--LQKQMEKKREKELSLKSRADDQEEPLEVSDGLS---------LLHAGEPNS 67
+EMQ K LQK E++++ E LK + E + L A E
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 68 KNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG--- 124
+ + +K+ LE+ + + L E D +L K+ ++ L++++EE+ A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 125 ---TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
TA + +I+ + +N L E + + R+ LT + E E E LT+L
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKN 1030
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKA--------LQDRLVATNLKMSDLRNQIQSVKQ 233
K + R + +++ E ++K +++ ++++L+ Q+ ++
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 234 ELRMAQKVLAREVGEDIN----VQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
EL+ A L E+ + N +++L + ++K ++ ++ LG+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 290 SAGTASDELSVYPDPRKLSA---QEKNLLR------IRSLEREKQEGLEKLASERDVLQR 340
D L ++L A QE +L+ RS E + QE +K A + L
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 341 ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGS 400
+LE+ K+ + + L E L ++ L + + + L Q+++LQ S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ----S 1266
Query: 401 LSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E+ R +LN + + + V + M+ E E K +L ++ L+
Sbjct: 1267 KCSDGERARA-------ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 461 NKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTR 520
+ + L++ T+ + + +L R+ SL L E +
Sbjct: 1320 TQ----------------ELLQEE--TRQKLNVSTKLRQLEEERN--SLQDQLDEEMEAK 1359
Query: 521 PSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEE---S 577
+L H ++ S +K Q S ++AL E + R + + L ++ EE +
Sbjct: 1360 QNL-ERHISTLNIQLSDSKKKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 578 NSKLLESERKLQEERHRTVV-LEQHLEKI-RLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
KL +++ +LQ+E VV L+ + + LE + Q A ++ R
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 636 TG----SEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRM 691
E K S A+ + +E++ EEL N+MLKA + + K++ +
Sbjct: 1475 EAEAREKETKALSLARALEEALEAK-EELE-------RTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 692 YHEI 695
HE+
Sbjct: 1527 VHEL 1530
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/522 (21%), Positives = 223/522 (42%), Gaps = 88/522 (16%)
Query: 5 ESSQNTLRLQFKAMQ-EMQHKRLQKQMEKKREKELSLKSR--------ADDQEEPLEVSD 55
E ++ L + K Q E + LQ Q++++ E + +L+ +D +++ + +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 56 GLSLLHAGEPNSKNSFE--------KRVLEDEIEHLRNELRETVDE-------NGRLYKL 100
+ L G+ + E K D++E +N L++ +D+ +L
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 101 L--KERDF-----EIKHLKKKIEEDRFAFTGTA----------GVAGDVVATKIVELSKK 143
L K+R F E K++ K ++R A A + EL +
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 144 NRLLMAESEGAKTRVKQLTNRIQELER----------ELQTALTRLSAKGATDAGAKPPR 193
N++L AE E + + + ELE+ E++T L L + AK R
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-R 1564
Query: 194 AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR--MAQKVLAREVGEDI- 250
++ +AL E + LQ R K L+ Q+ + EL Q+ LA + +
Sbjct: 1565 LEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 251 -NVQQL-LSSPGTWRGRAQ---QILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+++ L L + +GR + Q+ LQ+++++ +++L AR+ + DE+
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEI------- 1671
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRELE--ELKKKFEGMRSRNKLLSSE 362
+ ++N + +SLE + + E LA+ ER Q +LE EL ++ S L E
Sbjct: 1672 -FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMD-------QLKQLQEILGSLSLQEEKTRVSQHHL 415
+ L++++ L E+ + ++A+ D Q +QL L + +K ++ L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 416 DQQ---LNSEAQRSNSLV-AQLQAMVAEREAKVRQLEMEIGQ 453
++Q L S+ V ++ ++ +A EAK+ QLE ++ Q
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Score = 50.4 bits (119), Expect = 6e-06
Identities = 91/404 (22%), Positives = 167/404 (41%), Gaps = 42/404 (10%)
Query: 306 KLSAQEKNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + K LL++ E E K++ L+K + + EL+EL++K + L+ E
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQK-------HSQLTEE 888
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL------------SLQEEKTRV 410
L+ Q+ E +E+ L + ++L+EIL + LQ E+ ++
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSG 470
+Q LD + E + + QL+ + A EAK+++LE EI L + NK E
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKLEDEI--LVMDDQNNKLSKERKLL 1004
Query: 471 RE-VSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPS-PHR 528
E +S T E+ K+ + ++ L L + +R L +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNK-----HESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 529 TSPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
SD EQ QAQ++E+K Q A+ E + L + L + + N+ L +K
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELK--MQLAKKE-EELQAALARLDDEIAQKNNAL----KK 1112
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTS-NNRHNPTGSEKKDPSFA 646
++E L++ L+ R KA +R L T + + T ++++ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
+ ++ ++E T QV+E A L + E F+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.6 bits (179), Expect = 6e-13
Identities = 143/755 (18%), Positives = 286/755 (37%), Gaps = 88/755 (11%)
Query: 20 EMQHKRLQKQMEKKREKELSLKSRADDQ--------EEPLEVSDGLSLLHA---GEPNSK 68
+ Q L+ Q+ KK E+ + +R DD+ ++ E+ +S L E ++
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 69 NSFEK--RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTA 126
N EK R L +E+E L+ EL +T+D +L +R+ E+ LKK ++E+ +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 127 GVAGDVVATKIVELS--------------KKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
A + EL+ K + L E+ ++ L QE+E +
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 173 QTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
+ ++ + + + RA++ D+ EV+++ L K L + S+
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL--------VLQSKVQELEKQLG 284
+L+ Q++L E + +NV L R Q L L+ + L QL
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
++ + AS ++ ++ + +NL + EK +KL ++ LQ+EL++
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQ---QYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 345 L-----------------KKKFEGMRSRNKLLSS--------------EMKTLKSQMGTL 373
L ++KF+ + + K +SS E +T +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 374 VEKGRHDDELIDALMDQLK-QLQEILGS---LSLQEEKTRVSQHHLDQQLNSEAQRSNSL 429
+E+ E ++ LK ++++++ S + + S+ L+ Q+ + L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 430 VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKS 489
+LQ A +AK+R LE+ + L + R+ + + + Q E +
Sbjct: 1559 EDELQ---ATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEI 549
R++ + +E L L + R + + QAQ+ +
Sbjct: 1615 ER----------KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEP 609
+ + A RD + +K+ + + L++ + L + E++ E
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 610 GKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDV-PVESQMEELTTRLAIQV 668
+ + + A K L + E++ A V Q E+L+ LA +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 669 EENEMLKAALGSALRGKEEDFRMYHEILGQVKSVF 703
+ ++A R +E HE+ G VKS F
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Score = 72.8 bits (177), Expect = 1e-12
Identities = 153/765 (20%), Positives = 308/765 (40%), Gaps = 126/765 (16%)
Query: 19 QEMQHKRLQKQMEKKREKELSLKSRADDQE---EPLEVSDGLS----------LLHAGEP 65
+E + ++LQ + +K ++ L L+ + +++E + L++ + +L +
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 66 NSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDF-----------------EI 108
N+K S E+++LE+ I L L E ++ L KL + + E+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 109 KHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTN---RI 165
+ LK+K+E D F +A ++L+KK L A + Q N +I
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1120
Query: 166 QELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLR 225
+ELE + L ++ A A+ + +G+ E++AL+ L T + +
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGE-------ELEALKTELEDTLDSTATQQ 1173
Query: 226 NQIQSVKQELRMAQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
+QE+ + +K L E + VQ++ V+EL +QL
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELTEQLE 1220
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
Q + A ++ ++ + L+ + +R L + KQE + ++ L+ +++E
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQE----VEHKKKKLEAQVQE 1270
Query: 345 LKKK-FEGMRSRNKL------LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEI 397
L+ K +G R+R +L L +E++++ + K + + +L QL+ QE+
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
L +E+TR + ++ +L + NSL QL E EAK + LE I LN+
Sbjct: 1331 L------QEETR-QKLNVSTKLRQLEEERNSLQDQLD---EEMEAK-QNLERHISTLNIQ 1379
Query: 458 YLRNK-----------GVGEGSS--GREVSPAYTQFLE--------DPGLTKSPASAGDH 496
+K + EG +E+ Q+ E + + D
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 497 VGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAA 556
V L + R + S + + L S +++D ++ +A+ E KAL A
Sbjct: 1440 VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 557 EVE-----RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE--- 608
+E ++ L +L+ +E+ S + + + E LE +E+++ +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 609 -PGKASASQRAAPRTKTGLPTSNNR-------HNPTGSEKKDPSFAQLSDVPVESQMEEL 660
+ A++ A R + + + + EK+ QL + E + E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 661 TTRLAIQVEEN-----EMLKAALGSALRGKEEDFRMYHEILGQVK 700
LA ++ + L+ SA++G+EE + ++ Q+K
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Score = 69.7 bits (169), Expect = 9e-12
Identities = 90/393 (22%), Positives = 171/393 (43%), Gaps = 47/393 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +A++ + LQ + E+ EK L+ + + E LE L
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
A K+ LE +++ L + + K L++ ++K ++++E+ R
Sbjct: 1622 AAAA--------KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR- 1672
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAES-------EGAKTRVKQLTNRIQELERELQ 173
+ D + E KK + L A+ A+ KQ +EL EL
Sbjct: 1673 -------ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QS 230
++L+ +A + AQ+ + E ++A+ DR+ + L N++ +S
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 231 VKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-ILVLQSKVQELEKQLGQ-ARS 288
Q+ A++ L R+ E + +L G + + + I L++K+ +LE+Q+ Q AR
Sbjct: 1786 TAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 289 QSAGTAS---------DELSVYPDPRKLSAQ-----EKNLLRIRSLEREKQEGLE---KL 331
+ A T S + L D RK++ Q EK R++ L+R+ +E E ++
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMK 364
+ R LQREL+E + E M L S+++
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 68.2 bits (165), Expect = 3e-11
Identities = 146/724 (20%), Positives = 287/724 (39%), Gaps = 92/724 (12%)
Query: 19 QEMQHKR--LQKQMEKKREKELSLKSRADDQEEPLEVSDGLS---------LLHAGEPNS 67
+EMQ K LQK E++++ E LK + E + L A E
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 68 KNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG--- 124
+ + +K+ LE+ + + L E D +L K+ ++ L++++EE+ A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 125 ---TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
TA + +I+ + +N L E + + R+ LT + E E E LT+L
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKN 1037
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKA--------LQDRLVATNLKMSDLRNQIQSVKQ 233
K + R + +++ E ++K +++ ++++L+ Q+ ++
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 234 ELRMAQKVLAREVGEDIN----VQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
EL+ A L E+ + N +++L + ++K ++ ++ LG+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 290 SAGTASDELSVYPDPRKLSA---QEKNLLR------IRSLEREKQEGLEKLASERDVLQR 340
D L ++L A QE +L+ RS E + QE +K A + L
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 341 ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGS 400
+LE+ K+ + + L E L ++ L + + + L Q+++LQ S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ----S 1273
Query: 401 LSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E+ R +LN + + + V + M+ E E K +L ++ L+
Sbjct: 1274 KCSDGERARA-------ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 461 NKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTR 520
+ + L++ T+ + + +L R+ SL L E +
Sbjct: 1327 TQ----------------ELLQEE--TRQKLNVSTKLRQLEEERN--SLQDQLDEEMEAK 1366
Query: 521 PSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEE---S 577
+L H ++ S +K Q S ++AL E + R + + L ++ EE +
Sbjct: 1367 QNL-ERHISTLNIQLSDSKKKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 578 NSKLLESERKLQEERHRTVV-LEQHLEKI-RLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
KL +++ +LQ+E VV L+ + + LE + Q A ++ R
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 636 TG----SEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRM 691
E K S A+ + +E++ EEL N+MLKA + + K++ +
Sbjct: 1482 EAEAREKETKALSLARALEEALEAK-EELE-------RTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 692 YHEI 695
HE+
Sbjct: 1534 VHEL 1537
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/522 (21%), Positives = 223/522 (42%), Gaps = 88/522 (16%)
Query: 5 ESSQNTLRLQFKAMQ-EMQHKRLQKQMEKKREKELSLKSR--------ADDQEEPLEVSD 55
E ++ L + K Q E + LQ Q++++ E + +L+ +D +++ + +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 56 GLSLLHAGEPNSKNSFE--------KRVLEDEIEHLRNELRETVDE-------NGRLYKL 100
+ L G+ + E K D++E +N L++ +D+ +L
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 101 L--KERDF-----EIKHLKKKIEEDRFAFTGTA----------GVAGDVVATKIVELSKK 143
L K+R F E K++ K ++R A A + EL +
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 144 NRLLMAESEGAKTRVKQLTNRIQELER----------ELQTALTRLSAKGATDAGAKPPR 193
N++L AE E + + + ELE+ E++T L L + AK R
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-R 1571
Query: 194 AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR--MAQKVLAREVGEDI- 250
++ +AL E + LQ R K L+ Q+ + EL Q+ LA + +
Sbjct: 1572 LEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 251 -NVQQL-LSSPGTWRGRAQ---QILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+++ L L + +GR + Q+ LQ+++++ +++L AR+ + DE+
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEI------- 1678
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRELE--ELKKKFEGMRSRNKLLSSE 362
+ ++N + +SLE + + E LA+ ER Q +LE EL ++ S L E
Sbjct: 1679 -FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMD-------QLKQLQEILGSLSLQEEKTRVSQHHL 415
+ L++++ L E+ + ++A+ D Q +QL L + +K ++ L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 416 DQQ---LNSEAQRSNSLV-AQLQAMVAEREAKVRQLEMEIGQ 453
++Q L S+ V ++ ++ +A EAK+ QLE ++ Q
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Score = 50.4 bits (119), Expect = 6e-06
Identities = 91/404 (22%), Positives = 167/404 (41%), Gaps = 42/404 (10%)
Query: 306 KLSAQEKNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + K LL++ E E K++ L+K + + EL+EL++K + L+ E
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQK-------HSQLTEE 895
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL------------SLQEEKTRV 410
L+ Q+ E +E+ L + ++L+EIL + LQ E+ ++
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSG 470
+Q LD + E + + QL+ + A EAK+++LE EI L + NK E
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKLEDEI--LVMDDQNNKLSKERKLL 1011
Query: 471 RE-VSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPS-PHR 528
E +S T E+ K+ + ++ L L + +R L +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNK-----HESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 529 TSPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
SD EQ QAQ++E+K Q A+ E + L + L + + N+ L +K
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELK--MQLAKKE-EELQAALARLDDEIAQKNNAL----KK 1119
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTS-NNRHNPTGSEKKDPSFA 646
++E L++ L+ R KA +R L T + + T ++++ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
+ ++ ++E T QV+E A L + E F+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.6 bits (179), Expect = 6e-13
Identities = 143/755 (18%), Positives = 286/755 (37%), Gaps = 88/755 (11%)
Query: 20 EMQHKRLQKQMEKKREKELSLKSRADDQ--------EEPLEVSDGLSLLHA---GEPNSK 68
+ Q L+ Q+ KK E+ + +R DD+ ++ E+ +S L E ++
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 69 NSFEK--RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTA 126
N EK R L +E+E L+ EL +T+D +L +R+ E+ LKK ++E+ +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 127 GVAGDVVATKIVELS--------------KKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
A + EL+ K + L E+ ++ L QE+E +
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 173 QTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
+ ++ + + + RA++ D+ EV+++ L K L + S+
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL--------VLQSKVQELEKQLG 284
+L+ Q++L E + +NV L R Q L L+ + L QL
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
++ + AS ++ ++ + +NL + EK +KL ++ LQ+EL++
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQ---QYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 345 L-----------------KKKFEGMRSRNKLLSS--------------EMKTLKSQMGTL 373
L ++KF+ + + K +SS E +T +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 374 VEKGRHDDELIDALMDQLK-QLQEILGS---LSLQEEKTRVSQHHLDQQLNSEAQRSNSL 429
+E+ E ++ LK ++++++ S + + S+ L+ Q+ + L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 430 VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKS 489
+LQ A +AK+R LE+ + L + R+ + + + Q E +
Sbjct: 1559 EDELQ---ATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEI 549
R++ + +E L L + R + + QAQ+ +
Sbjct: 1615 ER----------KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEP 609
+ + A RD + +K+ + + L++ + L + E++ E
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 610 GKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDV-PVESQMEELTTRLAIQV 668
+ + + A K L + E++ A V Q E+L+ LA +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 669 EENEMLKAALGSALRGKEEDFRMYHEILGQVKSVF 703
+ ++A R +E HE+ G VKS F
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Score = 72.8 bits (177), Expect = 1e-12
Identities = 153/765 (20%), Positives = 308/765 (40%), Gaps = 126/765 (16%)
Query: 19 QEMQHKRLQKQMEKKREKELSLKSRADDQE---EPLEVSDGLS----------LLHAGEP 65
+E + ++LQ + +K ++ L L+ + +++E + L++ + +L +
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 66 NSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDF-----------------EI 108
N+K S E+++LE+ I L L E ++ L KL + + E+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 109 KHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTN---RI 165
+ LK+K+E D F +A ++L+KK L A + Q N +I
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1120
Query: 166 QELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLR 225
+ELE + L ++ A A+ + +G+ E++AL+ L T + +
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGE-------ELEALKTELEDTLDSTATQQ 1173
Query: 226 NQIQSVKQELRMAQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
+QE+ + +K L E + VQ++ V+EL +QL
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELTEQLE 1220
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
Q + A ++ ++ + L+ + +R L + KQE + ++ L+ +++E
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQE----VEHKKKKLEAQVQE 1270
Query: 345 LKKK-FEGMRSRNKL------LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEI 397
L+ K +G R+R +L L +E++++ + K + + +L QL+ QE+
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
L +E+TR + ++ +L + NSL QL E EAK + LE I LN+
Sbjct: 1331 L------QEETR-QKLNVSTKLRQLEEERNSLQDQLD---EEMEAK-QNLERHISTLNIQ 1379
Query: 458 YLRNK-----------GVGEGSS--GREVSPAYTQFLE--------DPGLTKSPASAGDH 496
+K + EG +E+ Q+ E + + D
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 497 VGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAA 556
V L + R + S + + L S +++D ++ +A+ E KAL A
Sbjct: 1440 VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 557 EVE-----RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE--- 608
+E ++ L +L+ +E+ S + + + E LE +E+++ +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 609 -PGKASASQRAAPRTKTGLPTSNNR-------HNPTGSEKKDPSFAQLSDVPVESQMEEL 660
+ A++ A R + + + + EK+ QL + E + E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 661 TTRLAIQVEEN-----EMLKAALGSALRGKEEDFRMYHEILGQVK 700
LA ++ + L+ SA++G+EE + ++ Q+K
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Score = 69.7 bits (169), Expect = 9e-12
Identities = 90/393 (22%), Positives = 171/393 (43%), Gaps = 47/393 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +A++ + LQ + E+ EK L+ + + E LE L
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
A K+ LE +++ L + + K L++ ++K ++++E+ R
Sbjct: 1622 AAAA--------KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR- 1672
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAES-------EGAKTRVKQLTNRIQELERELQ 173
+ D + E KK + L A+ A+ KQ +EL EL
Sbjct: 1673 -------ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QS 230
++L+ +A + AQ+ + E ++A+ DR+ + L N++ +S
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 231 VKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-ILVLQSKVQELEKQLGQ-ARS 288
Q+ A++ L R+ E + +L G + + + I L++K+ +LE+Q+ Q AR
Sbjct: 1786 TAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 289 QSAGTAS---------DELSVYPDPRKLSAQ-----EKNLLRIRSLEREKQEGLE---KL 331
+ A T S + L D RK++ Q EK R++ L+R+ +E E ++
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMK 364
+ R LQREL+E + E M L S+++
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 68.2 bits (165), Expect = 3e-11
Identities = 146/724 (20%), Positives = 287/724 (39%), Gaps = 92/724 (12%)
Query: 19 QEMQHKR--LQKQMEKKREKELSLKSRADDQEEPLEVSDGLS---------LLHAGEPNS 67
+EMQ K LQK E++++ E LK + E + L A E
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 68 KNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG--- 124
+ + +K+ LE+ + + L E D +L K+ ++ L++++EE+ A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 125 ---TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
TA + +I+ + +N L E + + R+ LT + E E E LT+L
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKN 1037
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKA--------LQDRLVATNLKMSDLRNQIQSVKQ 233
K + R + +++ E ++K +++ ++++L+ Q+ ++
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 234 ELRMAQKVLAREVGEDIN----VQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
EL+ A L E+ + N +++L + ++K ++ ++ LG+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 290 SAGTASDELSVYPDPRKLSA---QEKNLLR------IRSLEREKQEGLEKLASERDVLQR 340
D L ++L A QE +L+ RS E + QE +K A + L
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 341 ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGS 400
+LE+ K+ + + L E L ++ L + + + L Q+++LQ S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ----S 1273
Query: 401 LSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E+ R +LN + + + V + M+ E E K +L ++ L+
Sbjct: 1274 KCSDGERARA-------ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 461 NKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTR 520
+ + L++ T+ + + +L R+ SL L E +
Sbjct: 1327 TQ----------------ELLQEE--TRQKLNVSTKLRQLEEERN--SLQDQLDEEMEAK 1366
Query: 521 PSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEE---S 577
+L H ++ S +K Q S ++AL E + R + + L ++ EE +
Sbjct: 1367 QNL-ERHISTLNIQLSDSKKKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 578 NSKLLESERKLQEERHRTVV-LEQHLEKI-RLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
KL +++ +LQ+E VV L+ + + LE + Q A ++ R
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 636 TG----SEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRM 691
E K S A+ + +E++ EEL N+MLKA + + K++ +
Sbjct: 1482 EAEAREKETKALSLARALEEALEAK-EELE-------RTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 692 YHEI 695
HE+
Sbjct: 1534 VHEL 1537
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/522 (21%), Positives = 223/522 (42%), Gaps = 88/522 (16%)
Query: 5 ESSQNTLRLQFKAMQ-EMQHKRLQKQMEKKREKELSLKSR--------ADDQEEPLEVSD 55
E ++ L + K Q E + LQ Q++++ E + +L+ +D +++ + +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 56 GLSLLHAGEPNSKNSFE--------KRVLEDEIEHLRNELRETVDE-------NGRLYKL 100
+ L G+ + E K D++E +N L++ +D+ +L
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 101 L--KERDF-----EIKHLKKKIEEDRFAFTGTA----------GVAGDVVATKIVELSKK 143
L K+R F E K++ K ++R A A + EL +
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 144 NRLLMAESEGAKTRVKQLTNRIQELER----------ELQTALTRLSAKGATDAGAKPPR 193
N++L AE E + + + ELE+ E++T L L + AK R
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-R 1571
Query: 194 AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR--MAQKVLAREVGEDI- 250
++ +AL E + LQ R K L+ Q+ + EL Q+ LA + +
Sbjct: 1572 LEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 251 -NVQQL-LSSPGTWRGRAQ---QILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+++ L L + +GR + Q+ LQ+++++ +++L AR+ + DE+
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEI------- 1678
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRELE--ELKKKFEGMRSRNKLLSSE 362
+ ++N + +SLE + + E LA+ ER Q +LE EL ++ S L E
Sbjct: 1679 -FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMD-------QLKQLQEILGSLSLQEEKTRVSQHHL 415
+ L++++ L E+ + ++A+ D Q +QL L + +K ++ L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 416 DQQ---LNSEAQRSNSLV-AQLQAMVAEREAKVRQLEMEIGQ 453
++Q L S+ V ++ ++ +A EAK+ QLE ++ Q
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Score = 50.4 bits (119), Expect = 6e-06
Identities = 91/404 (22%), Positives = 167/404 (41%), Gaps = 42/404 (10%)
Query: 306 KLSAQEKNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + K LL++ E E K++ L+K + + EL+EL++K + L+ E
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQK-------HSQLTEE 895
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL------------SLQEEKTRV 410
L+ Q+ E +E+ L + ++L+EIL + LQ E+ ++
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSG 470
+Q LD + E + + QL+ + A EAK+++LE EI L + NK E
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKLEDEI--LVMDDQNNKLSKERKLL 1011
Query: 471 RE-VSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPS-PHR 528
E +S T E+ K+ + ++ L L + +R L +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNK-----HESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 529 TSPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
SD EQ QAQ++E+K Q A+ E + L + L + + N+ L +K
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELK--MQLAKKE-EELQAALARLDDEIAQKNNAL----KK 1119
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTS-NNRHNPTGSEKKDPSFA 646
++E L++ L+ R KA +R L T + + T ++++ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
+ ++ ++E T QV+E A L + E F+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.6 bits (179), Expect = 6e-13
Identities = 143/755 (18%), Positives = 286/755 (37%), Gaps = 88/755 (11%)
Query: 20 EMQHKRLQKQMEKKREKELSLKSRADDQ--------EEPLEVSDGLSLLHA---GEPNSK 68
+ Q L+ Q+ KK E+ + +R DD+ ++ E+ +S L E ++
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 69 NSFEK--RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTA 126
N EK R L +E+E L+ EL +T+D +L +R+ E+ LKK ++E+ +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 127 GVAGDVVATKIVELS--------------KKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
A + EL+ K + L E+ ++ L QE+E +
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 173 QTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
+ ++ + + + RA++ D+ EV+++ L K L + S+
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL--------VLQSKVQELEKQLG 284
+L+ Q++L E + +NV L R Q L L+ + L QL
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
++ + AS ++ ++ + +NL + EK +KL ++ LQ+EL++
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQ---QYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 345 L-----------------KKKFEGMRSRNKLLSS--------------EMKTLKSQMGTL 373
L ++KF+ + + K +SS E +T +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 374 VEKGRHDDELIDALMDQLK-QLQEILGS---LSLQEEKTRVSQHHLDQQLNSEAQRSNSL 429
+E+ E ++ LK ++++++ S + + S+ L+ Q+ + L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 430 VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKS 489
+LQ A +AK+R LE+ + L + R+ + + + Q E +
Sbjct: 1552 EDELQ---ATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 490 PASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEI 549
R++ + +E L L + R + + QAQ+ +
Sbjct: 1608 ER----------KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 550 KALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEP 609
+ + A RD + +K+ + + L++ + L + E++ E
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 610 GKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDV-PVESQMEELTTRLAIQV 668
+ + + A K L + E++ A V Q E+L+ LA +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 669 EENEMLKAALGSALRGKEEDFRMYHEILGQVKSVF 703
+ ++A R +E HE+ G VKS F
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Score = 72.8 bits (177), Expect = 1e-12
Identities = 153/765 (20%), Positives = 308/765 (40%), Gaps = 126/765 (16%)
Query: 19 QEMQHKRLQKQMEKKREKELSLKSRADDQE---EPLEVSDGLS----------LLHAGEP 65
+E + ++LQ + +K ++ L L+ + +++E + L++ + +L +
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 66 NSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDF-----------------EI 108
N+K S E+++LE+ I L L E ++ L KL + + E+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 109 KHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTN---RI 165
+ LK+K+E D F +A ++L+KK L A + Q N +I
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1113
Query: 166 QELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLR 225
+ELE + L ++ A A+ + +G+ E++AL+ L T + +
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGE-------ELEALKTELEDTLDSTATQQ 1166
Query: 226 NQIQSVKQELRMAQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
+QE+ + +K L E + VQ++ V+EL +QL
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELTEQLE 1213
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
Q + A ++ ++ + L+ + +R L + KQE + ++ L+ +++E
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGE------LRVLGQAKQE----VEHKKKKLEAQVQE 1263
Query: 345 LKKK-FEGMRSRNKL------LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEI 397
L+ K +G R+R +L L +E++++ + K + + +L QL+ QE+
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 398 LGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVH 457
L +E+TR + ++ +L + NSL QL E EAK + LE I LN+
Sbjct: 1324 L------QEETR-QKLNVSTKLRQLEEERNSLQDQLD---EEMEAK-QNLERHISTLNIQ 1372
Query: 458 YLRNK-----------GVGEGSS--GREVSPAYTQFLE--------DPGLTKSPASAGDH 496
+K + EG +E+ Q+ E + + D
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 497 VGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAA 556
V L + R + S + + L S +++D ++ +A+ E KAL A
Sbjct: 1433 VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 557 EVE-----RDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE--- 608
+E ++ L +L+ +E+ S + + + E LE +E+++ +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 609 -PGKASASQRAAPRTKTGLPTSNNR-------HNPTGSEKKDPSFAQLSDVPVESQMEEL 660
+ A++ A R + + + + EK+ QL + E + E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 661 TTRLAIQVEEN-----EMLKAALGSALRGKEEDFRMYHEILGQVK 700
LA ++ + L+ SA++G+EE + ++ Q+K
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Score = 69.7 bits (169), Expect = 9e-12
Identities = 90/393 (22%), Positives = 171/393 (43%), Gaps = 47/393 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
+ A E ++ L + +A++ + LQ + E+ EK L+ + + E LE L
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
A K+ LE +++ L + + K L++ ++K ++++E+ R
Sbjct: 1615 AAAA--------KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR- 1665
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAES-------EGAKTRVKQLTNRIQELERELQ 173
+ D + E KK + L A+ A+ KQ +EL EL
Sbjct: 1666 -------ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQI---QS 230
++L+ +A + AQ+ + E ++A+ DR+ + L N++ +S
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 231 VKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-ILVLQSKVQELEKQLGQ-ARS 288
Q+ A++ L R+ E + +L G + + + I L++K+ +LE+Q+ Q AR
Sbjct: 1779 TAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 289 QSAGTAS---------DELSVYPDPRKLSAQ-----EKNLLRIRSLEREKQEGLE---KL 331
+ A T S + L D RK++ Q EK R++ L+R+ +E E ++
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMK 364
+ R LQREL+E + E M L S+++
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 68.2 bits (165), Expect = 3e-11
Identities = 146/724 (20%), Positives = 287/724 (39%), Gaps = 92/724 (12%)
Query: 19 QEMQHKR--LQKQMEKKREKELSLKSRADDQEEPLEVSDGLS---------LLHAGEPNS 67
+EMQ K LQK E++++ E LK + E + L A E
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 68 KNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG--- 124
+ + +K+ LE+ + + L E D +L K+ ++ L++++EE+ A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 125 ---TAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
TA + +I+ + +N L E + + R+ LT + E E E LT+L
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKN 1030
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKA--------LQDRLVATNLKMSDLRNQIQSVKQ 233
K + R + +++ E ++K +++ ++++L+ Q+ ++
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 234 ELRMAQKVLAREVGEDIN----VQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
EL+ A L E+ + N +++L + ++K ++ ++ LG+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 290 SAGTASDELSVYPDPRKLSA---QEKNLLR------IRSLEREKQEGLEKLASERDVLQR 340
D L ++L A QE +L+ RS E + QE +K A + L
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 341 ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGS 400
+LE+ K+ + + L E L ++ L + + + L Q+++LQ S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ----S 1266
Query: 401 LSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E+ R +LN + + + V + M+ E E K +L ++ L+
Sbjct: 1267 KCSDGERARA-------ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 461 NKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTR 520
+ + L++ T+ + + +L R+ SL L E +
Sbjct: 1320 TQ----------------ELLQEE--TRQKLNVSTKLRQLEEERN--SLQDQLDEEMEAK 1359
Query: 521 PSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEE---S 577
+L H ++ S +K Q S ++AL E + R + + L ++ EE +
Sbjct: 1360 QNL-ERHISTLNIQLSDSKKKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 578 NSKLLESERKLQEERHRTVV-LEQHLEKI-RLEPGKASASQRAAPRTKTGLPTSNNRHNP 635
KL +++ +LQ+E VV L+ + + LE + Q A ++ R
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 636 TG----SEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRM 691
E K S A+ + +E++ EEL N+MLKA + + K++ +
Sbjct: 1475 EAEAREKETKALSLARALEEALEAK-EELE-------RTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 692 YHEI 695
HE+
Sbjct: 1527 VHEL 1530
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/522 (21%), Positives = 223/522 (42%), Gaps = 88/522 (16%)
Query: 5 ESSQNTLRLQFKAMQ-EMQHKRLQKQMEKKREKELSLKSR--------ADDQEEPLEVSD 55
E ++ L + K Q E + LQ Q++++ E + +L+ +D +++ + +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 56 GLSLLHAGEPNSKNSFE--------KRVLEDEIEHLRNELRETVDE-------NGRLYKL 100
+ L G+ + E K D++E +N L++ +D+ +L
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 101 L--KERDF-----EIKHLKKKIEEDRFAFTGTA----------GVAGDVVATKIVELSKK 143
L K+R F E K++ K ++R A A + EL +
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 144 NRLLMAESEGAKTRVKQLTNRIQELER----------ELQTALTRLSAKGATDAGAKPPR 193
N++L AE E + + + ELE+ E++T L L + AK R
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-R 1564
Query: 194 AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELR--MAQKVLAREVGEDI- 250
++ +AL E + LQ R K L+ Q+ + EL Q+ LA + +
Sbjct: 1565 LEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 251 -NVQQL-LSSPGTWRGRAQ---QILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPR 305
+++ L L + +GR + Q+ LQ+++++ +++L AR+ + DE+
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEI------- 1671
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRELE--ELKKKFEGMRSRNKLLSSE 362
+ ++N + +SLE + + E LA+ ER Q +LE EL ++ S L E
Sbjct: 1672 -FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMD-------QLKQLQEILGSLSLQEEKTRVSQHHL 415
+ L++++ L E+ + ++A+ D Q +QL L + +K ++ L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 416 DQQ---LNSEAQRSNSLV-AQLQAMVAEREAKVRQLEMEIGQ 453
++Q L S+ V ++ ++ +A EAK+ QLE ++ Q
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Score = 50.4 bits (119), Expect = 6e-06
Identities = 91/404 (22%), Positives = 167/404 (41%), Gaps = 42/404 (10%)
Query: 306 KLSAQEKNLLRIRSLERE---KQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSE 362
+L + K LL++ E E K++ L+K + + EL+EL++K + L+ E
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQK-------HSQLTEE 888
Query: 363 MKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL------------SLQEEKTRV 410
L+ Q+ E +E+ L + ++L+EIL + LQ E+ ++
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 411 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSG 470
+Q LD + E + + QL+ + A EAK+++LE EI L + NK E
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKLEDEI--LVMDDQNNKLSKERKLL 1004
Query: 471 RE-VSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPS-PHR 528
E +S T E+ K+ + ++ L L + +R L +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNK-----HESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 529 TSPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
SD EQ QAQ++E+K Q A+ E + L + L + + N+ L +K
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELK--MQLAKKE-EELQAALARLDDEIAQKNNAL----KK 1112
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTS-NNRHNPTGSEKKDPSFA 646
++E L++ L+ R KA +R L T + + T ++++ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 647 QLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFR 690
+ ++ ++E T QV+E A L + E F+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 72.8 bits (177), Expect = 1e-12
Identities = 159/739 (21%), Positives = 303/739 (41%), Gaps = 106/739 (14%)
Query: 25 RLQKQMEKKREKELSLKSRADDQEEPL-----EVSDGLSLLHAGEPNSKNSFEKRVLEDE 79
+LQ+++E R +S KSR + E+ L EV++ L + +P +L+ E
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ-E 540
Query: 80 IEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVE 139
I L+ +L T ++ R LKE + +K + + T + + +K+
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
Query: 140 LSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTR-LSAKGATDAGAKPPRAQMGD 198
+K+N ++A K++++ Q+ EL+ + ++ L + A A K +M
Sbjct: 601 ANKENSDVIAL---WKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL 657
Query: 199 RALLETPEVKALQDRLVATNLK-MSDLRNQIQSVKQELRMAQKVLAREV--GED---INV 252
E ++ QD A + K M LR ++ V +E + + + ++ ED + +
Sbjct: 658 DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 717
Query: 253 QQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEK 312
+ L+ + +++ VLQ+K E K + SQ T ++L RK S++ K
Sbjct: 718 EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT-EEKLLDLDALRKASSEGK 776
Query: 313 NLLR------------IRSLEREK------------------------QEGLEKLASERD 336
+ ++ I+ LE EK QE L +++ ++
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 337 VLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQE 396
L++EL+ LK+KF S E +++ M V K +E + L L++L+E
Sbjct: 837 TLEKELQILKEKFAE-------ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 397 ILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNV 456
L + E K R +Q + ++ + N +A++ M + +++ ++ E+
Sbjct: 890 NLADM---EAKFREKDEREEQLIKAKEKLEND-IAEIMKMSGDNSSQLTKMNDEL----- 940
Query: 457 HYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVES 516
L+ + V E + FL+ S D + S+ + H +
Sbjct: 941 -RLKERDVEELQLKLTKANENASFLQ--------KSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 517 ALTRPSLPSPHRTSPRFSD-SPEQKGWQAQVSEIKALWQAAEVE-RDRLTEFVTVLQKRV 574
L R + SD + + Q E+KA ++ A E + + E + LQK
Sbjct: 992 ELER-----------KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK-- 1038
Query: 575 EESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHN 634
LL++E KL+ R L Q LE++R + KA A+Q A + +
Sbjct: 1039 -----TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKT 1092
Query: 635 PTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRMYHE 694
T + +D + ++ ++++++ L VEE K L + K E+FR E
Sbjct: 1093 ETLASLED---TKQTNAKLQNELDTLKENNLKNVEELNKSKELL-TVENQKMEEFRKEIE 1148
Query: 695 ILGQV---KSVFLQALRQQ 710
L Q KS L AL+++
Sbjct: 1149 TLKQAAAQKSQQLSALQEE 1167
Score = 72.4 bits (176), Expect = 1e-12
Identities = 170/818 (20%), Positives = 329/818 (40%), Gaps = 161/818 (19%)
Query: 2 AADESSQNTLRLQFKAMQEM--QHKRLQKQMEK------------KREKELSLKSRADDQ 47
A +E+ Q ++ + A +++ +++ L+ ++E K + E ++ S
Sbjct: 568 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 627
Query: 48 EE-PLEVSDGLSLLHAGEPNSKNSFEKRVLE--DEIEHLRNE--------LRETVDENGR 96
EE + S GL A K EK L+ EIE+L+N+ +E +
Sbjct: 628 EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK 687
Query: 97 LYKLLKERDFEIKHLKKKIE--EDRFAFTGTAGVAGDVVATKIVELS---KKNRLLMAES 151
L K++KE++ ++ ++ K++ ED+ V + K+ E K+ +L A+
Sbjct: 688 LMKVIKEKENSLEAIRSKLDKAEDQHL------VEMEDTLNKLQEAEIKVKELEVLQAKC 741
Query: 152 EGAKTRVKQLTNRIQELERELQT--ALTRLSAKGATDAGAKPPRAQMGDRAL-------- 201
+ T++++ E +L AL + S++G ++ + + ++ +
Sbjct: 742 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 202 LETPEVKALQDRLVATNLKMSDLRNQIQSVKQ-------ELRMAQKVLAREVGEDINVQQ 254
E+ + ++ L LK+++L+ + V Q EL++ ++ A E ++VQ+
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 861
Query: 255 LLSSP-GTWRGRAQQILVLQSKVQEL-----------------EKQLGQARSQ------- 289
+ + +Q +L S +++L E+QL +A+ +
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 290 ---SAGTASDELSVYPDPRKLSAQEKNLLRIR--------------------SLEREKQE 326
+G S +L+ D +L ++ L+++ E+ +QE
Sbjct: 922 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 981
Query: 327 GLEKLASERDVLQRELEELKKKFE-------GMRSRNKLLSSEMKTLKSQMGTLVEKGRH 379
+K E+ L+R+L +L+KK E +++R + +SE KT ++ ++K
Sbjct: 982 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1041
Query: 380 D--DELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV 437
D D+L A + LQE L L Q +K + +Q D E + A +
Sbjct: 1042 DTEDKLKGAREENSGLLQE-LEELRKQADKAKAAQTAEDAMQIMEQMTKEK--TETLASL 1098
Query: 438 AEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLED-----PGLTKSPAS 492
+ + +L+ E+ L + L+N V E + +E+ Q +E+ L ++ A
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNLKN--VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156
Query: 493 AGDHVG-----------RLGSSRSVTSLGHTLVE--SALTRPSLPSPHRTSPRFSDSPEQ 539
+ LG SR + L E S L L R S D+ E+
Sbjct: 1157 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1216
Query: 540 K-GWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVL 598
K Q +S AL + E ++L VTVL R E +++K L S VV
Sbjct: 1217 KASLQKSISITSALLTEKDAELEKLRNEVTVL--RGENASAKSLHS-----------VVQ 1263
Query: 599 EQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQME 658
+K++LE K + K L +S+ T ++ + AQ ESQ++
Sbjct: 1264 TLESDKVKLEL-KVKNLELQLKENKRQLSSSSGN---TDTQADEDERAQ------ESQID 1313
Query: 659 ELTTRLAIQVEENEMLKAAL----GSALRGKEEDFRMY 692
L + + +N+ LK + +AL G +D Y
Sbjct: 1314 FLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNY 1351
Score = 58.2 bits (139), Expect = 3e-08
Identities = 123/746 (16%), Positives = 302/746 (40%), Gaps = 93/746 (12%)
Query: 10 TLRLQFKAMQEMQHKRLQK---QMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPN 66
+L+ F A +E K ++ EK ++ SLKS+ + + E SD ++L +
Sbjct: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK--ENSDVIALWKSKLET 618
Query: 67 SKNSFEKRVLEDEIEH---LRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ S ++ + E ++ L E E + ++ K+ + EI++L+ + + +R A
Sbjct: 619 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH- 677
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELER-ELQTALTRLSAK 182
A ++ L K ++ E E + ++ ++ ++ E++ L +L
Sbjct: 678 ----------AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 727
Query: 183 GATDAGAKPPRAQMGDRALLE---TPEVKALQDRLV---ATNLKMSDLRNQIQSVKQELR 236
+ +A+ ++ + T ++KA +++L+ A S+ +++++ ++Q+L
Sbjct: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 237 MAQKVLAR-EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQE-------LEKQLGQARS 288
A+K + E+ ++ + S +GR ++ LQ + E LEK+L +
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
Query: 289 QSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKK 348
+ A + + +SV ++++ + +K+E L+S+ + L+ L +++ K
Sbjct: 848 KFAEASEEAVSV----------QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
Query: 349 FEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKT 408
F R + L + L++ + +++ + + + D+L+ + + L L+ K
Sbjct: 898 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
Query: 409 RVSQHHLDQQLNS---EAQRSNSLVA--------QLQAMVAEREAKVRQLEMEIGQLNVH 457
+ L + + +A++S A +L+ +++ E K+ + +L
Sbjct: 958 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 458 YLRNKGVGEG--------------------SSGREVSPAYTQFLEDPGLTKSPASAGDHV 497
Y R + RE + Q LE+ A A
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ-- 1075
Query: 498 GRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAE 557
+ ++ + E T SL +T+ + Q ++ +K
Sbjct: 1076 ---TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL---------QNELDTLKENNLKNV 1123
Query: 558 VERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQR 617
E ++ E +TV +++EE ++ ++ ++ + L++ K+ E G++
Sbjct: 1124 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1183
Query: 618 AAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAA 677
+ + + NN+ +K++ F + +D S + ++ A+ E++ L+
Sbjct: 1184 SHQKLEEERSVLNNQ--LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241
Query: 678 LG--SALRGKEEDFRMYHEILGQVKS 701
+ LRG+ + H ++ ++S
Sbjct: 1242 RNEVTVLRGENASAKSLHSVVQTLES 1267
Score = 42.4 bits (98), Expect = 0.002
Identities = 77/354 (21%), Positives = 145/354 (40%), Gaps = 47/354 (13%)
Query: 147 LMAESEGAKTRVKQLTNRIQELERELQTA-------LTRLSAK----GATDAGAKPPRAQ 195
L+AE + + V + T+ + E+E+EL A + L AK A + +
Sbjct: 367 LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 196 MGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQL 255
+ ++ E +V+ LQ R+ ++ DL Q + ++ ++ L E + +Q+
Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRE 486
Query: 256 LSSPGTWRGRAQQILVLQSKVQELEKQLG---------QARSQSAGTASD-ELSVYPDPR 305
L + +S++ ELEK L + R +S A D ++S+
Sbjct: 487 LEDTRV------ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL-------EELKKKFEGMRSR--- 355
S QEK + +RE E + + Q+E+ E+L K+ E ++S+
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
Query: 356 -NKLLSSEMKTLKSQMGTLVEKGRHD-DELIDALMDQLKQLQEILGSLSLQEEKTRVSQH 413
NK S + KS++ T + + +EL + L L Q EK R+
Sbjct: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
Query: 414 H----LDQQLNSE----AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYL 459
H L Q +SE A+ +L A+L ++ E+E + + ++ + +L
Sbjct: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 714
Score = 39.3 bits (90), Expect = 0.013
Identities = 65/322 (20%), Positives = 135/322 (41%), Gaps = 56/322 (17%)
Query: 322 REKQEGLEKLASERDVLQRELE-------ELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV 374
+EKQ+ +E+L +ERD+ + E+ E++++ R + E++ Q+ T+V
Sbjct: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
Query: 375 EKG-RHDDELIDALMDQLKQLQEI----------LGSLSLQEEKTRVSQHHLDQQLNSEA 423
E R EL++ L ++ ++++++ G L Q + L+Q L E
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 424 QRSNSLVAQLQ----AMVAEREAKVRQLE-------MEIGQLNVHYLRNKGVGEGSSGRE 472
+++ L +L+ A V+E+ +++ +LE E+ +L NK G+
Sbjct: 478 TKADKLQRELEDTRVATVSEK-SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536
Query: 473 VSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSL-GHTLVESALTRPSLPSPHRTSP 531
+ + E +T++ DH R +TSL H + + + + +
Sbjct: 537 LLQEISSLQEKLEVTRT-----DH------QREITSLKEHFGAREETHQKEIKALYTATE 585
Query: 532 RFSDSPEQ-----KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESER 586
+ S E + + S++ ALW + +L + Q+ +EE + +
Sbjct: 586 KLSKENESLKSKLEHANKENSDVIALW------KSKLETAIASHQQAMEELK---VSFSK 636
Query: 587 KLQEERHRTVVLEQHLEKIRLE 608
L E L+ +EK+RL+
Sbjct: 637 GLGTETAEFAELKTQIEKMRLD 658
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 72.8 bits (177), Expect = 1e-12
Identities = 103/478 (21%), Positives = 206/478 (43%), Gaps = 49/478 (10%)
Query: 13 LQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFE 72
L+ K + E ++ L KQ+++ + E+ ++ Q++ LE+ LHA ++ ++
Sbjct: 1030 LEIKLLNE-KNISLTKQIDQLSKDEVGKLTQIIQQKD-LEIQ----ALHARISSTSHT-- 1081
Query: 73 KRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDV 132
++ +L+ +L+ E +++ +L E+ E HLK + + D+
Sbjct: 1082 -----QDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM-----------DI 1125
Query: 133 VATK---IVELSKKNRLLMAESEGA-KTRVKQLTNRIQELERELQTALTRLSAKGATDAG 188
VA K +++L +N+ L E + + ++ + + RE + LS K T
Sbjct: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLA 1185
Query: 189 AKPPRAQMGDRALLETPEVKAL---QDRLVATNLKMSDLRNQIQSVKQELRMAQKVLARE 245
+ + + + + + L +D+L KM + + Q+ + Q ++ L E
Sbjct: 1186 VLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
Query: 246 VGEDINVQQLLSSPGT------WRGRAQQILVLQSKVQELEKQLGQARSQSAG---TASD 296
+ + + Q L+ S + G Q ++K++ ++L Q + S G D
Sbjct: 1246 LHQ-LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ-HSIGQLCNTKD 1303
Query: 297 ELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRN 356
L D +LL +S E + E L+ ++LQ+ELEEL+K + +
Sbjct: 1304 LLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATI 1363
Query: 357 KLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLD 416
+ L L + E R + E D+ + QLK+ Q++L L +EK + + D
Sbjct: 1364 RTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL--QKLLKEKDLLIKAKSD 1421
Query: 417 QQLNSEAQRSNSLVAQ--LQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGRE 472
Q L+S +N + L+ V + ++ LEM+IG+L N+ + E G+E
Sbjct: 1422 QLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG---ENEKIVETYRGKE 1476
Score = 61.2 bits (147), Expect = 3e-09
Identities = 97/480 (20%), Positives = 215/480 (44%), Gaps = 53/480 (11%)
Query: 25 RLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLR 84
RL+ ++ R + K++ D + E+ +++ + N + + E+ L+
Sbjct: 183 RLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDH--QHEMSVLQ 240
Query: 85 NELRETVDENGRLYKLLKERDFEIKHLKKKIEE-DRFAFTGTAGVAGDVVATKIVELSKK 143
N ++ + E R ++ E+ +++IEE + G +GV + +KI E+ K
Sbjct: 241 NAHQQKLTEISRRHRE------ELSDYEERIEELENLLQQGGSGVI-ETDLSKIYEMQKT 293
Query: 144 NRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDA-GAKPPRAQMGDRALL 202
++L E + +++QL ++I+++ ++L SA+ D + + + R ++
Sbjct: 294 IQVLQIEKVESTKKMEQLEDKIKDINKKLS------SAENDRDILRREQEQLNVEKRQIM 347
Query: 203 ETPEVKALQ-DRLVATNLKMSDLRNQIQSVKQELRMAQKV--LAREVGEDINVQQLLSSP 259
E E L+ +L + +K SD + + + + ++V L + + + N LSS
Sbjct: 348 EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSL 407
Query: 260 GTWRGRAQQILVLQSKVQELEKQ---LGQARSQSAGTASDELSVYPDPRKLSAQEKNL-- 314
A+ L L+ +++ LEK+ L Q + + + + Y + + ++ +L
Sbjct: 408 NQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDS 467
Query: 315 ----LRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQM 370
LR+ +LE ++QE L + SE++ L E+EEL ++ + L+ ++ +++
Sbjct: 468 ELHDLRL-NLEAKEQE-LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG 525
Query: 371 GTLVEKGRHD--------DELIDALMDQLKQL----------QEILGSLSLQEEKTRVSQ 412
+++ K + D +L D MD K+L + L L L ++K
Sbjct: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 413 HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGRE 472
+L QLN ++Q SN +Q E + +RQ E E+ ++ +++ S+ ++
Sbjct: 586 ENLVDQLN-KSQESN---VSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD 641
Score = 60.8 bits (146), Expect = 4e-09
Identities = 109/516 (21%), Positives = 218/516 (42%), Gaps = 101/516 (19%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E + N L L + +++ + + L Q+ K +E +S+ Q+E LE+ + +
Sbjct: 568 EVALNDLHLTKQKLED-KVENLVDQLNKSQESNVSI------QKENLELKEHI------- 613
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLY---KLLKERDFEIKHLKKKIEEDRFA 121
R E+E+ +RNEL ++++++ LLKER+ E+++LK+ + E
Sbjct: 614 ---------RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQL 664
Query: 122 FTGTAGVAGDV-------------VATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQEL 168
VA DV V ++ E N L E T V+ L E+
Sbjct: 665 NENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK---NTIVETLKMEKGEI 721
Query: 169 ERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATN----LKMSDL 224
E EL A RL + + ++ + L T ++ + L+ N +++++L
Sbjct: 722 EAELCWAKKRLLEEANK---YEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAEL 778
Query: 225 RNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLG 284
+ I+ + + + + VL+ + E + QL++ ++I + K++E +L
Sbjct: 779 KKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINK--------KEIFI--EKLKERSSKL- 827
Query: 285 QARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEE 344
+EL Y A KN + +++E EK L + E + LQ ELE
Sbjct: 828 ----------QEELDKYS-----QALRKNEILRQTIE-EKDRSLGSMKEENNHLQEELER 871
Query: 345 LKKKFEGMRSRN------KLLSS--EMKTLKSQMGT----LVEKGRHDDELID------- 385
L+++ +SR K L S E+ + SQ+ T L E+ +H ++I+
Sbjct: 872 LREE----QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927
Query: 386 ALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVR 445
L+ L++ ++ + Q E+ + L + + E + + Q++ + E ++
Sbjct: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987
Query: 446 QLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFL 481
+I Q +++ + GS ++S A T+ L
Sbjct: 988 TDNSDIFQET--KVQSLNIENGSEKHDLSKAETERL 1021
Score = 47.4 bits (111), Expect = 5e-05
Identities = 109/556 (19%), Positives = 236/556 (42%), Gaps = 56/556 (10%)
Query: 69 NSFEKRVLEDEIEHLRNELRETVD-ENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAG 127
N +EK + +E+ + RN + E+ L KL +++D EI LKK IE+ T
Sbjct: 737 NKYEKTI--EELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETK- 793
Query: 128 VAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDA 187
DV+++ + E K+ L+ + E ++K+ ++++QE + AL + T
Sbjct: 794 ---DVLSSSLEE-QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849
Query: 188 GAKPPRAQMGDRALLETPEVKALQDRLVAT----NLKMSDLRNQIQSVKQELRMAQKVLA 243
M + E++ L++ T + K D ++ S +L ++ L
Sbjct: 850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 244 REVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPD 303
E+ Q+++ + Q + L +QE +K++ + R Q + ++ +
Sbjct: 910 EEIKHH---QKIIED------QNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
Query: 304 -PRKLSAQEKNLLRIRSLEREKQEGLE----KLASERDVLQRELEELKKKFEGMRSRNKL 358
++ + +K + +I++ E+++ ++ + E V +E +K + ++ +
Sbjct: 961 KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
Query: 359 LSSEMKTLKSQMGTLVEKGRHDDELIDAL-MDQLKQLQEILGSLSLQEEKTRVSQHHLDQ 417
L +K + ++ L EK + ID L D++ +L +I +Q++ + H
Sbjct: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI-----IQQKDLEIQALHARI 1075
Query: 418 QLNSEAQRSNSLVAQLQAMVAERE---AKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVS 474
S Q L QLQA ERE A + + E L Y + + + +E +
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDI---VAAKEAA 1132
Query: 475 PAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRT--SPR 532
Q E+ L+ S+G + R ++ +L + E + +L +T +
Sbjct: 1133 LIKLQD-ENKKLSTRFESSGQDMFR----ETIQNLSRIIREKDIEIDALSQKCQTLLAVL 1187
Query: 533 FSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEER 592
+ S + ++ + L Q ERD+L + V K++EE +++ + + +Q
Sbjct: 1188 QTSSTGNEAGGVNSNQFEELLQ----ERDKLKQQV----KKMEEWKQQVMTTVQNMQ--- 1236
Query: 593 HRTVVLEQHLEKIRLE 608
H + L++ L +++ +
Sbjct: 1237 HESAQLQEELHQLQAQ 1252
Score = 38.5 bits (88), Expect = 0.022
Identities = 136/733 (18%), Positives = 281/733 (38%), Gaps = 94/733 (12%)
Query: 16 KAMQEMQHKRLQ--KQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEK 73
K +Q +Q ++++ K+ME+ +K + + E ++ + + EK
Sbjct: 292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDI--------LRREQEQLNVEK 343
Query: 74 RVLEDEIEHLRNELRE-----------------------TVDENGRLYKLLKERDFEIKH 110
R + +E E+L+ E + +V+E RL + L + + EI
Sbjct: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMR 403
Query: 111 LKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELER 170
L +++ A + +I L K+ LL E E + + +L N + ++
Sbjct: 404 LSSLNQDNSLAEDNLK------LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK- 456
Query: 171 ELQTALTRLSAKGATDAGAKPPRAQMGDRAL-LETPEVKALQDRLVATNL--KMSDLRNQ 227
TA +S +++ D L LE E + Q L ++ +L Q
Sbjct: 457 --STATRDISLD-----------SELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQ 503
Query: 228 IQSVKQELRMAQKVLAREVGE-DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQA 286
Q + + + + L+++ E D + +L + R Q L+ ++ K+L
Sbjct: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ---LEDDKMDITKELDVQ 560
Query: 287 RSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEK--LASERDVLQRELEE 344
+ + + ++ +KL + +NL+ + +E ++K L + + Q E E
Sbjct: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEEL 620
Query: 345 LKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLS-- 402
+ + E M+S N+ +S K TL+++ + + + +L+QL E L ++
Sbjct: 621 SRIRNELMQSLNQDSNSNFKD------TLLKEREAEVRNLKQNLSELEQLNENLKKVAFD 674
Query: 403 --LQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
++ EK ++ + QL +N L + +V + + ++E E+ L
Sbjct: 675 VKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLE 734
Query: 461 N-----KGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVE 515
K + E S+ R ++ + Q LE L K + L + H +
Sbjct: 735 EANKYEKTIEELSNARNLNTSALQ-LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETK 793
Query: 516 SALT-----RPSLPSPHRTSPRFSDSPEQKG--WQAQVSEIKALWQAAEVERDRLTEFVT 568
L+ + L F + +++ Q ++ + + E+ R + E
Sbjct: 794 DVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 569 VLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPT 628
L EE+N E ER L+EE+ RT + + L+ AS+ + T
Sbjct: 854 SLGSMKEENNHLQEELER-LREEQSRTAPV---ADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 629 SNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEED 688
+H+ E ++ S QL E + E R ++E + A K+E+
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRY-----QHEQMNATHTQLFLEKDEE 964
Query: 689 FRMYHEILGQVKS 701
+ + + Q+K+
Sbjct: 965 IKSLQKTIEQIKT 977
Score = 36.2 bits (82), Expect = 0.11
Identities = 81/407 (19%), Positives = 163/407 (40%), Gaps = 63/407 (15%)
Query: 14 QFKAMQEMQHKRLQKQMEKKREKELSLKSRADD----QEEPLEVSDGLSLLHAGEPNSKN 69
Q K Q++ K L +EK+L +K+++D E + LL N K
Sbjct: 1397 QLKEKQDVLQKLL-------KEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKE 1449
Query: 70 SFEKRVLEDEIEHLRNELRETVDE--------------NGRLYKLLKERDFEIKHLKKK- 114
+LE +I L+ E + V+ N + +L+E++FE +K+K
Sbjct: 1450 RI--LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKA 1507
Query: 115 ------IEEDRFAFTGTAGVAGDVVATK----IVELSKKNRLLMA--ESEGAKTRVKQLT 162
++E TG + V + +V +++++++A + + T ++
Sbjct: 1508 LAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEV 1567
Query: 163 NRIQELERELQTALTRLSAKGATDAGAKPPRAQMG-DRALLETPEVKALQDRLVATNLKM 221
R+++ E L RL + A DR +V L+++LV+++ M
Sbjct: 1568 QRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAM 1627
Query: 222 SDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQ---- 277
+ +Q + L+ V++++ D QL S + A + LQ ++
Sbjct: 1628 ENASHQASVQVESLQEQLNVVSKQ--RDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ 1685
Query: 278 --------ELEKQ---LGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQE 326
ELEKQ + + + + +S+ + +A + R+ K+E
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEE 1745
Query: 327 GLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTL 373
+E+L + ++ Q L++++KK + + SSE K K M L
Sbjct: 1746 QIEELKRQNELRQEMLDDVQKKLMSLAN-----SSEGKVDKVLMRNL 1787
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 72.4 bits (176), Expect = 1e-12
Identities = 170/818 (20%), Positives = 329/818 (40%), Gaps = 161/818 (19%)
Query: 2 AADESSQNTLRLQFKAMQEM--QHKRLQKQMEK------------KREKELSLKSRADDQ 47
A +E+ Q ++ + A +++ +++ L+ ++E K + E ++ S
Sbjct: 533 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 592
Query: 48 EE-PLEVSDGLSLLHAGEPNSKNSFEKRVLE--DEIEHLRNE--------LRETVDENGR 96
EE + S GL A K EK L+ EIE+L+N+ +E +
Sbjct: 593 EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK 652
Query: 97 LYKLLKERDFEIKHLKKKIE--EDRFAFTGTAGVAGDVVATKIVELS---KKNRLLMAES 151
L K++KE++ ++ ++ K++ ED+ V + K+ E K+ +L A+
Sbjct: 653 LMKVIKEKENSLEAIRSKLDKAEDQHL------VEMEDTLNKLQEAEIKVKELEVLQAKC 706
Query: 152 EGAKTRVKQLTNRIQELERELQT--ALTRLSAKGATDAGAKPPRAQMGDRAL-------- 201
+ T++++ E +L AL + S++G ++ + + ++ +
Sbjct: 707 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766
Query: 202 LETPEVKALQDRLVATNLKMSDLRNQIQSVKQ-------ELRMAQKVLAREVGEDINVQQ 254
E+ + ++ L LK+++L+ + V Q EL++ ++ A E ++VQ+
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 826
Query: 255 LLSSP-GTWRGRAQQILVLQSKVQEL-----------------EKQLGQARSQ------- 289
+ + +Q +L S +++L E+QL +A+ +
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 886
Query: 290 ---SAGTASDELSVYPDPRKLSAQEKNLLRIR--------------------SLEREKQE 326
+G S +L+ D +L ++ L+++ E+ +QE
Sbjct: 887 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 946
Query: 327 GLEKLASERDVLQRELEELKKKFE-------GMRSRNKLLSSEMKTLKSQMGTLVEKGRH 379
+K E+ L+R+L +L+KK E +++R + +SE KT ++ ++K
Sbjct: 947 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1006
Query: 380 D--DELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV 437
D D+L A + LQE L L Q +K + +Q D E + A +
Sbjct: 1007 DTEDKLKGAREENSGLLQE-LEELRKQADKAKAAQTAEDAMQIMEQMTKEK--TETLASL 1063
Query: 438 AEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLED-----PGLTKSPAS 492
+ + +L+ E+ L + L+N V E + +E+ Q +E+ L ++ A
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNLKN--VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121
Query: 493 AGDHVG-----------RLGSSRSVTSLGHTLVE--SALTRPSLPSPHRTSPRFSDSPEQ 539
+ LG SR + L E S L L R S D+ E+
Sbjct: 1122 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1181
Query: 540 K-GWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVL 598
K Q +S AL + E ++L VTVL R E +++K L S VV
Sbjct: 1182 KASLQKSISITSALLTEKDAELEKLRNEVTVL--RGENASAKSLHS-----------VVQ 1228
Query: 599 EQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQME 658
+K++LE K + K L +S+ T ++ + AQ ESQ++
Sbjct: 1229 TLESDKVKLEL-KVKNLELQLKENKRQLSSSSGN---TDTQADEDERAQ------ESQID 1278
Query: 659 ELTTRLAIQVEENEMLKAAL----GSALRGKEEDFRMY 692
L + + +N+ LK + +AL G +D Y
Sbjct: 1279 FLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNY 1316
Score = 58.2 bits (139), Expect = 3e-08
Identities = 123/746 (16%), Positives = 302/746 (40%), Gaps = 93/746 (12%)
Query: 10 TLRLQFKAMQEMQHKRLQK---QMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPN 66
+L+ F A +E K ++ EK ++ SLKS+ + + E SD ++L +
Sbjct: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK--ENSDVIALWKSKLET 583
Query: 67 SKNSFEKRVLEDEIEH---LRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFT 123
+ S ++ + E ++ L E E + ++ K+ + EI++L+ + + +R A
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH- 642
Query: 124 GTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELER-ELQTALTRLSAK 182
A ++ L K ++ E E + ++ ++ ++ E++ L +L
Sbjct: 643 ----------AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 692
Query: 183 GATDAGAKPPRAQMGDRALLE---TPEVKALQDRLV---ATNLKMSDLRNQIQSVKQELR 236
+ +A+ ++ + T ++KA +++L+ A S+ +++++ ++Q+L
Sbjct: 693 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 237 MAQKVLAR-EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQE-------LEKQLGQARS 288
A+K + E+ ++ + S +GR ++ LQ + E LEK+L +
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 289 QSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKK 348
+ A + + +SV ++++ + +K+E L+S+ + L+ L +++ K
Sbjct: 813 KFAEASEEAVSV----------QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 862
Query: 349 FEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKT 408
F R + L + L++ + +++ + + + D+L+ + + L L+ K
Sbjct: 863 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 922
Query: 409 RVSQHHLDQQLNS---EAQRSNSLVA--------QLQAMVAEREAKVRQLEMEIGQLNVH 457
+ L + + +A++S A +L+ +++ E K+ + +L
Sbjct: 923 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
Query: 458 YLRNKGVGEG--------------------SSGREVSPAYTQFLEDPGLTKSPASAGDHV 497
Y R + RE + Q LE+ A A
Sbjct: 983 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ-- 1040
Query: 498 GRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAE 557
+ ++ + E T SL +T+ + Q ++ +K
Sbjct: 1041 ---TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL---------QNELDTLKENNLKNV 1088
Query: 558 VERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQR 617
E ++ E +TV +++EE ++ ++ ++ + L++ K+ E G++
Sbjct: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1148
Query: 618 AAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAA 677
+ + + NN+ +K++ F + +D S + ++ A+ E++ L+
Sbjct: 1149 SHQKLEEERSVLNNQ--LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1206
Query: 678 LG--SALRGKEEDFRMYHEILGQVKS 701
+ LRG+ + H ++ ++S
Sbjct: 1207 RNEVTVLRGENASAKSLHSVVQTLES 1232
Score = 46.6 bits (109), Expect = 8e-05
Identities = 73/333 (21%), Positives = 138/333 (41%), Gaps = 40/333 (12%)
Query: 147 LMAESEGAKTRVKQLTNRIQELERELQTA-------LTRLSAK----GATDAGAKPPRAQ 195
L+AE + + V + T+ + E+E+EL A + L AK A + +
Sbjct: 367 LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 196 MGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQL 255
+ ++ E +V+ LQ R+ ++ DL S K + +K LA V E +++
Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRR 486
Query: 256 LSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLL 315
L S G L L ++ L+++L R+ R++++ +++
Sbjct: 487 LES-NKPAGDVDMSLSLLQEISSLQEKLEVTRTD-------------HQREITSLKEH-- 530
Query: 316 RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVE 375
+ E Q+ ++ L + + L +E E LK K E NK S + KS++ T +
Sbjct: 531 -FGAREETHQKEIKALYTATEKLSKENESLKSKLE---HANKENSDVIALWKSKLETAIA 586
Query: 376 KGRHD-DELIDALMDQLKQLQEILGSLSLQEEKTRVSQHH----LDQQLNSE----AQRS 426
+ +EL + L L Q EK R+ H L Q +SE A+
Sbjct: 587 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM 646
Query: 427 NSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYL 459
+L A+L ++ E+E + + ++ + +L
Sbjct: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679
Score = 37.4 bits (85), Expect = 0.049
Identities = 34/134 (25%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 322 REKQEGLEKLASERDVLQRELE-------ELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV 374
+EKQ+ +E+L +ERD+ + E+ E++++ R + E++ Q+ T+V
Sbjct: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
Query: 375 EKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQ 434
E D E ++ L++QL++ + + L + E+ +++ L+ SE R L L
Sbjct: 418 EAA--DREKVE-LLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLA 474
Query: 435 AMVAEREAKVRQLE 448
V E R+LE
Sbjct: 475 LRVQEVAELRRRLE 488
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 72.4 bits (176), Expect = 1e-12
Identities = 158/753 (20%), Positives = 304/753 (40%), Gaps = 126/753 (16%)
Query: 24 KRLQKQMEKKREKELSLKSRADDQ---------------EEPLEVSDGLSLLHAGEPNSK 68
+RL+K+++ K E+ + S D EE + D L+ + ++
Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816
Query: 69 NSFEK-RVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAG 127
F+ + L + E + + ++EN R+ + EI +L K+ ++ F + G
Sbjct: 817 QEFQNFKTLHMDFEQ---KYKMVLEENERMNQ-------EIVNLSKEAQK----FDSSLG 862
Query: 128 VAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNR---IQELERE---LQTALTRLSA 181
++ K EL +K R + + +QL NR +Q +ERE + L +
Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE 922
Query: 182 KGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSD-LRNQIQSVKQE---LRM 237
+ T K Q+ + +E ++K+ V N+ + LRN ++S+KQ +
Sbjct: 923 EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT 982
Query: 238 AQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDE 297
+ ++ EV ++++++ + G + QQ +V K Q+LE + +Q+ +
Sbjct: 983 LKSKISEEVSRNLHMEE---NTGETKDEFQQKMVGIDKKQDLEAK----NTQTLTADVKD 1035
Query: 298 LSVYPDPRKLSA--QEKNLLR--IRSLEREKQ-------EGLEKLASERDVLQRELEELK 346
+ RK+ + QEKN L+ + S+ EK+ E +E ++ L+ +ELK
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELK 1095
Query: 347 K-------------KFEGMRSR--NKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQL 391
K K EG SR ++L E K LK + L EK + + + + +
Sbjct: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK-LKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 392 KQLQEI------LGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQ------------- 432
K++ EI L + L E + L Q+LN + S+ +
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFET 1214
Query: 433 ----LQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTK 488
L+ + E EA Q + E+ ++H ++ + R VS Q + L K
Sbjct: 1215 ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID-ELRRSVSEKTAQIINTQDLEK 1273
Query: 489 SPASAGDHVGRLGSSR----SVTSLGHT---------LVESALTRPSLPSPH------RT 529
S + + L + +V + T L E + T+ S R
Sbjct: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
Query: 530 SPRFSDSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKL 588
+ +F +S E+ K + +K + +A EV+ D+L E + +++ES SK E +
Sbjct: 1334 NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK-QEQSLNM 1392
Query: 589 QEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQL 648
+E+ + T + +E+ + + + L S++ EK D +L
Sbjct: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD--LQRL 1450
Query: 649 SDVPVESQMEELTTRL----AIQVEENEMLKAA 677
+V ++S+ ++L + A +E E LK A
Sbjct: 1451 QEV-LQSESDQLKENIKEIVAKHLETEEELKVA 1482
Score = 54.3 bits (129), Expect = 4e-07
Identities = 93/461 (20%), Positives = 189/461 (40%), Gaps = 77/461 (16%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRAD-DQEEPLE----VSDGLSL 59
ES N+LR + + + +++L+ + K E EL LK + D D+ E LE + L
Sbjct: 497 ESELNSLRADYDNLV-LDYEQLRTE---KEEMELKLKEKNDLDEFEALERKTKKDQEMQL 552
Query: 60 LHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKK-----K 114
+H N KN + + ++ L NEL V+ LL+E++ +IK L++ K
Sbjct: 553 IHEIS-NLKNLVKHAEVYNQ--DLENELSSKVE-------LLREKEDQIKKLQEYIDSQK 602
Query: 115 IEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQT 174
+E + + + D K + L A+ E A R + L ++E +EL T
Sbjct: 603 LENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL--ELKEKMKELAT 660
Query: 175 ALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQE 234
++ +++ Q +L A DL ++QS E
Sbjct: 661 TYKQMEN------------------------DIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
Query: 235 LRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTA 294
+ ++ +V +D+ L L+ K+ +L+K+L + ++
Sbjct: 697 ITKLTSLIDGKVPKDLLCN----------------LELEGKITDLQKELNKEVEENEALR 740
Query: 295 SDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRS 354
+ + + +L + + R+R ++K E L + SE+D L E+ + + +G+
Sbjct: 741 EEVILL----SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 355 RNKLLSSEMKTLKSQMGTLVE-----KGRHDD--ELIDALMDQLKQLQEILGSLSLQEEK 407
++ T +S + + K H D + ++++ +++ + + +LS + +K
Sbjct: 797 EIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
Query: 408 TRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
S L +L+ + Q ++Q + E E QLE
Sbjct: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Score = 53.9 bits (128), Expect = 5e-07
Identities = 91/468 (19%), Positives = 194/468 (41%), Gaps = 41/468 (8%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
+ SQ +++ K +EM+ + Q+E+ + KE + + A +E + L + E
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 65 PNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTG 124
K E L+++ E + L EN RL ++L E E++ + K+ +D +
Sbjct: 1639 TQEKMC-EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE-RDDLRSVEE 1696
Query: 125 TAGVAGDVVATKIVE-----LSKKNRLLMAES---------EGAKTRVKQLTNRIQELER 170
T V D + + E L K+ L + + + V + TN I +++
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756
Query: 171 ELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQS 230
+L+ + L A+ ++ + + +K Q+ + +S+ +++ +
Sbjct: 1757 DLEHSNDALKAQDL----------KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN 1806
Query: 231 VKQELRMAQKVLAREVGE-DINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQ 289
++++L + L ++ E N QL++ + + Q KV E+E+ Q + Q
Sbjct: 1807 MQKDLENSNAKLQEKIQELKANEHQLITLK-------KDVNETQKKVSEMEQLKKQIKDQ 1859
Query: 290 SAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREK---QEGLEKLASERDVLQRELEELK 346
S + E+ +KL +NL ++S+ +E+ + E L ERD L+ L+E K
Sbjct: 1860 SLTLSKLEIENLNLAQKL---HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETK 1916
Query: 347 KKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEE 406
+ ++ K K K + L EK I + L + ++ L + +
Sbjct: 1917 ARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQ 1976
Query: 407 KTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL 454
K + + + +N ++ N + QL+ + ++ + M+ QL
Sbjct: 1977 KKELQLLRVKEDVNMSHKKINEM-EQLKKQFEAQNLSMQSVRMDNFQL 2023
Score = 51.2 bits (121), Expect = 3e-06
Identities = 86/484 (17%), Positives = 198/484 (40%), Gaps = 56/484 (11%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL 60
++ E+ +T++ Q +A+ + ++Q+ EK E++ ++K ++ QE+ E+
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEK--EEQFNIKQISEVQEKVNELKQFKEHR 1557
Query: 61 HAGEPNSKNSFEKRVLE--DEIEHLRNELRETVDENGRLYKL----------LKERDFEI 108
A + ++ S E ++LE + ++ + E++ + E + ++ LKE EI
Sbjct: 1558 KAKD-SALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI 1616
Query: 109 KHLKKKIEEDRFAFTGTAGV-AGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQE 167
K+ +E + F V +I L ++ E +T +LT + E
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676
Query: 168 LERELQTALTRLSAKGATDAGAKPPRAQMGD-------RALLETPEVKALQDRLVATNLK 220
E+++ + + K R Q+ + R L + E+K + L
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736
Query: 221 MSDLRNQIQSVKQELRMAQKVLARE----VGEDINVQQLLSSPGTWRGRAQQILVLQSKV 276
+ LR + E+ QK L +D+ +Q+ ++ + +
Sbjct: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE-------------ELRIAHMHL 1783
Query: 277 QELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERD 336
+E ++ + + R G S++ KLS +K+L + +EK + L+ +
Sbjct: 1784 KEQQETIDKLR----GIVSEKTD------KLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 337 VLQRELEELKKKFEGMRSRNKLLSSEMKTLKS---QMGTLVEKGRHDDELIDALMDQLKQ 393
L++++ E +KK M K + + TL + L +K + E + ++M +
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 394 LQEILGSLSLQEEKTRVSQHHL---DQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME 450
L+ + +L L+ ++ + S D ++ E + + L + + V + K+ + ++
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 451 IGQL 454
I +
Sbjct: 1954 ISDI 1957
Score = 50.4 bits (119), Expect = 6e-06
Identities = 131/684 (19%), Positives = 272/684 (39%), Gaps = 124/684 (18%)
Query: 20 EMQHKR--LQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLE 77
E Q K + K+ + + + +L + D E + SL+ E N + V+
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ--EKNELQQMLESVIA 1064
Query: 78 DEIEHLRNELRETVD---ENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVA 134
++ E L+ +L+E ++ EN +LL + + + + + + G D +A
Sbjct: 1065 EK-EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA 1123
Query: 135 TKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRA 194
+L +K++ L E + V++ + +Q+ E++ L K T + R
Sbjct: 1124 EVEEKLKEKSQQLQ-EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 195 QMGDRALLETPEVKAL-QDRLVATNLKMS------DLRNQIQSV-------KQELRMA-- 238
++ + EVK++ ++R V L+ S LR I+ + K+EL++A
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
Query: 239 ------------QKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQA 286
++ ++ + + IN Q L S + Q+ + + + QEL + +
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKS----HTKLQEEIPVLHEEQELLPNVKEV 1298
Query: 287 RSQSAGTASD-----ELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRE 341
S++ T ++ E S D L+ E LR+ +E QE ++ L ERD L+
Sbjct: 1299 -SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTI 1357
Query: 342 LEELKKKFEGMR---------------------------SRNKLLSSEMKTLKSQMGTLV 374
E L+ K + ++ + + SEM+ K + L+
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 375 E------------KGRHDD-ELIDALMDQLKQLQEILGSLS--LQEEKTRVSQHHLDQQL 419
+ HD+ + + D L++LQE+L S S L+E + HL+ +
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE 1477
Query: 420 NSEA-----QRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVS 474
+ + + +L+ ++E+E ++ ++ ++ +N L+NK +
Sbjct: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN-DKLQNK----------IQ 1526
Query: 475 PAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFS 534
Y + E+ K + + V L + H + + + + R
Sbjct: 1527 EIYEK--EEQFNIKQISEVQEKVNELKQFKE-----HRKAKDSALQSIESKMLELTNRLQ 1579
Query: 535 DSPEQ-KGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSK---------LLES 584
+S E+ + + E+K + +A ++ERD+L E + +++ES K + E+
Sbjct: 1580 ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639
Query: 585 ERKLQEERHRTVVLEQHLEKIRLE 608
+ K+ E H E +K+ LE
Sbjct: 1640 QEKMCEIEHLKEQFE--TQKLNLE 1661
Score = 46.6 bits (109), Expect = 8e-05
Identities = 89/427 (20%), Positives = 177/427 (41%), Gaps = 55/427 (12%)
Query: 5 ESSQNTLRLQFKAMQE---MQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLH 61
E S + L+ Q +QE + H L++Q E +K + S E +D LS +
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLKEQQETI-DKLRGIVS---------EKTDKLSNMQ 1808
Query: 62 AGEPNSKNSFEKRVLEDEI-EHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
NS ++++ E + EH L++ V+E +++ E++ LKK+I++
Sbjct: 1809 KDLENSNAKLQEKIQELKANEHQLITLKKDVNET-------QKKVSEMEQLKKQIKDQSL 1861
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
+ + +A K+ E ++ + +M E + + + L +L+ LQ R
Sbjct: 1862 TLSKLE-IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR-- 1918
Query: 181 AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQK 240
+ + A+M + ET V L++++ +++SD++ + K EL+ +
Sbjct: 1919 ---DLEIQQELKTARMLSKEHKET--VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973
Query: 241 VLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSV 300
L ++ + + V++ + + K+ E+E+ Q +Q+ S +
Sbjct: 1974 ELQKKELQLLRVKE-------------DVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020
Query: 301 YPDPRKLSAQEKNLLRIRSLEREKQE---GLEKLASERDVLQRELEELKKKFEGMRSRNK 357
+ +KL ++L IR + +E+ E E L ERD L E+ + +N
Sbjct: 2021 FQLTKKL---HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR----DRQNH 2073
Query: 358 LLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQ---EILGSLSLQEEKTRVSQHH 414
+ E + L L E R I L+ + ++ E L LSL EK Q
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133
Query: 415 LDQQLNS 421
L ++ +
Sbjct: 2134 LSMRVKA 2140
Score = 35.8 bits (81), Expect = 0.14
Identities = 88/458 (19%), Positives = 181/458 (39%), Gaps = 61/458 (13%)
Query: 11 LRLQFKAMQ-EMQHKRLQK-QMEKKREKELS-LKSRADDQEEPLEVSDGLSL-------- 59
L+ QF+A MQ R+ Q+ KK + L ++ A +++E + + L +
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIAT 2061
Query: 60 ----LHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIK------ 109
+ N + EKR+L D +HL LRE L K E D +
Sbjct: 2062 LREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLS 2121
Query: 110 -HLKKKIE-EDRFAFTGTAGVAGDVVATKIVE-LSKKNRLLMAESEGAKTRVKQLTNRIQ 166
L+K+IE + + A ++ + TK +E L N+ E ++K + + +
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181
Query: 167 ELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRN 226
+++ E ++ + + EV+ ++ L+ K+ L+
Sbjct: 2182 KIKEEQHESINKFE--------------------MDFIDEVEKQKELLI----KIQHLQQ 2217
Query: 227 QIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQA 286
+ELR L D++++++L I +V K++ Q
Sbjct: 2218 DCDVPSRELR----DLKLNQNMDLHIEEILKDFS--ESEFPSIKTEFQQVLSNRKEMTQF 2271
Query: 287 RSQSAGTASDELSVYPDPRKLS---AQEKNLL--RIRSLEREKQEGLEKLASERDVLQRE 341
+ T D + +K + Q N RI ++ E E E+ A+ +++
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQD 2331
Query: 342 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL 401
L+ LK+K E + + L + + + +Q+ + ++ A ++++E+ SL
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLAS-GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSL 2390
Query: 402 SLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAE 439
+E + + ++ E + +N ++A+LQA V E
Sbjct: 2391 HEAKESAMHKESKI-IKMQKELEVTNDIIAKLQAKVHE 2427
Score = 33.1 bits (74), Expect = 0.92
Identities = 42/199 (21%), Positives = 87/199 (43%), Gaps = 31/199 (15%)
Query: 273 QSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL- 331
+ ++ +L+KQL + ++ A ++ D +EK+LL+ ++ EK E L ++
Sbjct: 349 RKEIMDLKKQLEEVSLETRAQAMEK-----DQLAQLLEEKDLLQ--KVQNEKIENLTRML 401
Query: 332 -ASERDVLQRELEELKK--------KFEGMRSRNKL------LSSEMKTLKSQMGTLVEK 376
S LQ+EL+ +K K M++ N + KT K + L
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLL--- 458
Query: 377 GRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAM 436
R DE + + D + L + ++Q +++ +LNS ++LV + +
Sbjct: 459 -REIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
Query: 437 VAEREAKVRQLEMEIGQLN 455
E+E ++E+++ + N
Sbjct: 518 RTEKE----EMELKLKEKN 532
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 71.2 bits (173), Expect = 3e-12
Identities = 143/710 (20%), Positives = 293/710 (41%), Gaps = 78/710 (10%)
Query: 16 KAMQEMQHK--RLQKQMEKKREKELSL-KSRADDQEEPLEVSDGLSLLHAGEPNSKNSFE 72
K ++E+Q + L++++E +R + K R+D E E+S+ L AG S
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE--EAGGATSVQIEM 1163
Query: 73 KRVLEDEIEHLRNELRETVDENGRLYKLLKERDFE-----------IKHLKKKIEEDRFA 121
+ E E + +R +L E ++ L+++ + ++ +K+K+E+++
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 122 FTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSA 181
F + D V + + ++ K L + ++ + ++ +E +R + LT A
Sbjct: 1224 FK----LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND-LTSQRA 1278
Query: 182 KGATDAGAKPPR--------AQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
K T+ G + +Q+ L T +++ L+ +L + L + +QS +
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGT----WRGRAQQILVLQSK-VQELEKQLGQARS 288
+ + ++ E +Q++LS + WR + + + +++ ++E +K+L Q R
Sbjct: 1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ-RL 1397
Query: 289 QSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEK---LASERDVLQRE---- 341
Q A A + ++ K S+ EK R+++ + +E+ A+ D QR
Sbjct: 1398 QEAEEAVEAVNA-----KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 342 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSL 401
L E K+K+E +S + E ++L +++ L E ++ + K LQE + L
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Query: 402 SLQEEKTRVSQHHLD---QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHY 458
+ Q + + H L+ +QL +E S + + +A + E K+ + ++E Q+
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572
Query: 459 LRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESAL 518
R E+ A L ++ A SR+ +E L
Sbjct: 1573 ERKL----AEKDEEMEQAKRNHLRVVDSLQTSLDAETR------SRNEALRVKKKMEGDL 1622
Query: 519 TRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESN 578
+ H + K Q+ + + + A D L E + ++++R
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR----- 1677
Query: 579 SKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGS 638
+ LL++E L+E R V+EQ E+ R K + + + L S N
Sbjct: 1678 NNLLQAE--LEELR---AVVEQ-TERSR----KLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 639 EKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEED 688
+K D +QL VE ++E R A + + + AA+ + KE+D
Sbjct: 1728 KKMDADLSQL-QTEVEEAVQE--CRNAEEKAKKAITDAAMMAEELKKEQD 1774
Score = 63.2 bits (152), Expect = 8e-10
Identities = 102/492 (20%), Positives = 211/492 (42%), Gaps = 74/492 (15%)
Query: 8 QNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNS 67
+N L+LQ +A Q+ +++ ++ + ++ L+++ + E LE + E N+
Sbjct: 884 KNDLQLQVQAEQD-NLADAEERCDQLIKNKIQLEAKVKEMNERLEDEE--------EMNA 934
Query: 68 KNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHL---------------- 111
+ + +KR LEDE L+ ++ + ++ K + ++K+L
Sbjct: 935 ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 994
Query: 112 -KKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELER 170
KK ++E D V T + + K + + EG+ + K++ ++ +R
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNT-LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 171 ELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRL-----VATNL--KMSD 223
+L+ L +L+ + D + + Q+ +R + E+ AL R+ + + L K+ +
Sbjct: 1054 KLEGDL-KLTQESIMDL--ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 224 LRNQIQSVKQELRMAQKV----------LAREVGEDINVQQLLSSPGTWRGRAQQILVLQ 273
L+ +I+ +++EL + L+RE+ E+I+ ++L + G + + +
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSREL-EEIS-ERLEEAGGATSVQIEMNKKRE 1168
Query: 274 SKVQELEKQLGQARSQSAGTASDELSVYPDP-RKLSAQEKNLLRIRSLEREKQEGLEKLA 332
++ Q++ + L +A Q TA+ + D +L Q NL R++ +KL
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK----------QKLE 1218
Query: 333 SERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLK 392
E+ + EL+++ E + L +TL+ QM K ++ L Q
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRA 1278
Query: 393 QLQEILGSLS--LQEEKTRVSQ------------HHLDQQLNSEAQRSNSLVAQLQAMVA 438
+LQ G LS L E++ +SQ L +QL E + N+L LQ+
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338
Query: 439 EREAKVRQLEME 450
+ + Q E E
Sbjct: 1339 DCDLLREQYEEE 1350
Score = 60.1 bits (144), Expect = 7e-09
Identities = 145/736 (19%), Positives = 288/736 (39%), Gaps = 118/736 (16%)
Query: 4 DESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADD---QEEPLEVSDG---- 56
D +S ++ KA E + L+ QM + R K + +D Q L+ +G
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Query: 57 --------LSLLHAGEPNSKNSFE--KRVLEDEIEH-----------------LRNELRE 89
+S L G+ E KR LE+E++ LR + E
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 90 TVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMA 149
+ L ++L + + E+ + K E D T A +A ++ E + + A
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 150 ESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKA 209
+ + +L N I++L +++ + +A A+ + E+++
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 210 LQDRLVATNLKMSDLRNQIQSVKQEL---RMAQKVLAREVGEDINVQQLLSSPGTWRGRA 266
Q + + ++ L+N + + L + K L E+ + +QL SS T
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD--LTEQLGSSGKTIHELE 1527
Query: 267 QQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQE 326
+ L+++ EL+ L +A + L + ++ A+ + L + E E+ +
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587
Query: 327 G-----LEKLASERDVLQRELEE---LKKKFEG--------MRSRNKLLSSEMKTLKSQM 370
++ L + D R E +KKK EG + N++ + K +KS
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Query: 371 GTLVEKGRHDDELIDALMDQLKQ-----------LQEILGSLSLQEEKTRVSQHHLDQQL 419
L + D+ + A D LK+ LQ L L E+T S+ +Q+L
Sbjct: 1648 SLLKDTQIQLDDAVRA-NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1706
Query: 420 NSEAQRSNSLVAQLQAMVAER---EAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPA 476
++R L +Q +++ ++ +A + QL+ E+ + V RN E + + ++ A
Sbjct: 1707 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA-VQECRN---AEEKAKKAITDA 1762
Query: 477 YTQFLEDPGLTKSPASAGDHVGRLGSS--RSVTSLGHTLVESALTRPSLPSPHRTSPRFS 534
E K H+ R+ + +++ L H L E+
Sbjct: 1763 AMMAEE----LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA------------------ 1800
Query: 535 DSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQE---- 590
+ KG + Q+ +++A + E+E + E QKR ES + +SER+++E
Sbjct: 1801 EQIALKGGKKQLQKLEA--RVRELENELEAE-----QKRNAESVKGMRKSERRIKELTYQ 1853
Query: 591 ---ERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQ 647
+R + L+ ++K++L K A +R A + T+ ++ E + +
Sbjct: 1854 TEEDRKNLLRLQDLVDKLQL---KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE--E 1908
Query: 648 LSDVPVESQMEELTTR 663
+D+ ESQ+ +L +
Sbjct: 1909 RADI-AESQVNKLRAK 1923
Score = 52.4 bits (124), Expect = 1e-06
Identities = 84/427 (19%), Positives = 176/427 (41%), Gaps = 60/427 (14%)
Query: 8 QNTLRLQFKAMQEMQHKRLQKQMEK---KREKELSLKSRADDQEEP----LEVSDGLSLL 60
Q+ L +++ + K L+ Q+E K E E L + ++ E+ L V D L
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 61 HAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF 120
E S+N E ++ ++E NE+ + R+ E ++K L+ +++ +
Sbjct: 1601 LDAETRSRN--EALRVKKKMEGDLNEMEIQLSHANRM---AAEAQKQVKSLQSLLKDTQI 1655
Query: 121 AFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLS 180
A D + I + ++N LL AE E + V+Q + E+EL R+
Sbjct: 1656 QLDDAVR-ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Query: 181 AKGATDAGAKPPRAQM-GDRALLETPEVKALQD---------------RLVATNLKMS-D 223
+ + + +M D + L+T +A+Q+ ++A LK D
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774
Query: 224 LRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQL 283
++ +K+ + K L + E + +G +Q+ L+++V+ELE +L
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQI--------ALKGGKKQLQKLEARVRELENEL 1826
Query: 284 GQARSQSA----GTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQ 339
+ ++A G E + + KNLLR++ L ++KL + +
Sbjct: 1827 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDL-------VDKLQLKVKAYK 1879
Query: 340 RELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILG 399
R+ EE +++ S+ + + E+ ++ ++ ++ +++L+ +G
Sbjct: 1880 RQAEEAEEQANTNLSKFRKVQHEL-----------DEAEERADIAESQVNKLRAKSRDIG 1928
Query: 400 SLSLQEE 406
+ L EE
Sbjct: 1929 TKGLNEE 1935
Score = 50.8 bits (120), Expect = 4e-06
Identities = 102/522 (19%), Positives = 220/522 (42%), Gaps = 82/522 (15%)
Query: 208 KALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQ 267
K L++++V+ + +DL+ Q+Q+ + L A++ QL+ +
Sbjct: 871 KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE----------RCDQLIKNK-------- 912
Query: 268 QILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNL-LRIRSLEREK-- 324
+ L++KV+E+ ++L +A + + + + +L +L L + +E+EK
Sbjct: 913 --IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970
Query: 325 -QEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDEL 383
+ ++ L E L + +L K+ + ++ ++ +++ + ++ TL + ++
Sbjct: 971 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Query: 384 IDALMDQLKQLQEIL-----------GSLSLQEEKT---RVSQHHLDQQL---------- 419
+D L L+Q +++ G L L +E + LD++L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 420 NSEAQRSNSLVAQLQAMVAEREAKVRQLEMEI-----GQLNVHYLRNKGVGEGSSGREVS 474
N+ + +L +QLQ + E +A++ +LE E+ + V LR+ RE+
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS------DLSRELE 1144
Query: 475 PAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFS 534
++ LE+ G S + + L ++ T +L H +
Sbjct: 1145 -EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH------A 1197
Query: 535 DSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHR 594
DS + G Q+ ++ + Q E E+ +EF L V + ++++++ L E+ R
Sbjct: 1198 DSVAELG--EQIDNLQRVKQKLEKEK---SEFKLELDD-VTSNMEQIIKAKANL-EKMCR 1250
Query: 595 TVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLS--DVP 652
T+ + + + + E + S + + R K L T N + ++K+ +QL+ +
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAK--LQTENGELS-RQLDEKEALISQLTRGKLT 1307
Query: 653 VESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRMYHE 694
Q+E+L Q+EE K AL AL+ D + E
Sbjct: 1308 YTQQLEDLKR----QLEEEVKAKNALAHALQSARHDCDLLRE 1345
Score = 33.5 bits (75), Expect = 0.71
Identities = 83/404 (20%), Positives = 160/404 (39%), Gaps = 57/404 (14%)
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKT 365
KL + K LL +S EREK+ +AS ++ E LK+ E +R K L +M +
Sbjct: 831 KLYFKIKPLL--KSAEREKE-----MAS----MKEEFTRLKEALEKSEARRKELEEKMVS 879
Query: 366 LKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQR 425
L + L + + A D L +E L + + ++++L E +
Sbjct: 880 LLQEKNDLQLQ-------VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932
Query: 426 SNSLVA---QLQAMVAEREAKVRQLEMEIGQL--NVHYLRN--KGVGEGSSG-------- 470
+ L A +L+ +E + + LE+ + ++ H N K + E +G
Sbjct: 933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Query: 471 ----REVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSP 526
+ + A+ Q L+D + + ++ + V L +L + R L
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDKVNTLTK-AKVKLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 527 HRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEF-VTVLQKRVEESNSKLLESE 585
R + K Q + +++ Q + ER + +F + L R+E+ + + +
Sbjct: 1052 KRKL-----EGDLKLTQESIMDLENDKQQLD-ERLKKKDFELNALNARIEDEQALGSQLQ 1105
Query: 586 RKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSF 645
+KL+E + R LE+ LE ++R A L + +R SE+ + +
Sbjct: 1106 KKLKELQARIEELEEELE-----------AERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 646 AQLS-DVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEED 688
S + + + E ++ +EE + A +ALR K D
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1198
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 70.5 bits (171), Expect = 5e-12
Identities = 171/763 (22%), Positives = 296/763 (38%), Gaps = 153/763 (20%)
Query: 3 ADESSQNTLRLQFKAMQEMQHKRLQKQMEKK-REKELS---LKSRADDQEEPLEVSDGLS 58
A+ +Q +LR Q +A E +RLQ++ E RE E L+S+ ++E L L+
Sbjct: 976 AEREAQASLREQ-RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL-----LA 1029
Query: 59 LLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEED 118
L A EK L +EI L+ E DE L + K++ +K +K +
Sbjct: 1030 RLEA---------EKEELSEEIAALQQER----DEGLLLAESEKQQALSLKESEKTALSE 1076
Query: 119 RFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALT- 177
+ T + +AT +E+ ++ R + E ++ V LT+ +++L + + A
Sbjct: 1077 KLMGTRHS------LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA 1130
Query: 178 -----RLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
R + A D G + D L E E++ Q RL+ LR ++ +
Sbjct: 1131 HAQEVRRLQEQARDLG------KQRDSCLREAEELRT-QLRLLED--ARDGLRRELLEAQ 1181
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAG 292
++LR +Q+ G ++ Q+ + A++ L+ +EL + +A S+
Sbjct: 1182 RKLRESQE------GREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI- 1234
Query: 293 TASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGM 352
S +L+ +KL+ E+ + E + GL+++ R +REL+EL+++ + +
Sbjct: 1235 --SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
Query: 353 RSRNKLLSSEMKTLKSQ--MGTLVEKGRHDDEL------------IDALMDQL----KQL 394
S N L E+ L+ + +G EK + L ++ + +L ++L
Sbjct: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
Query: 395 QE-----------ILGSLSLQEEKTRVSQHHLDQ----QLNSEAQRSNSL---------- 429
QE +LGSL EE + LD +L EA R+ +
Sbjct: 1353 QEQEGEFRTRERRLLGSL---EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAE 1409
Query: 430 --VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLT 487
L+A +A E + R E ++G L R G+G S P
Sbjct: 1410 GRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS--------------PAPR 1455
Query: 488 KSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSD------------ 535
P S GS + S TL S ++P P P TSP D
Sbjct: 1456 PVPGSPARDAPAEGSGEGLNS-PSTLECSPGSQPPSPGP-ATSPASPDLDPEAVRGALRE 1513
Query: 536 --------SPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKL------ 581
E+ + Q S + E ERD T LQK V ES
Sbjct: 1514 FLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
Query: 582 ---LESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHN--PT 636
+++E LQEE R E+ R + + +R+ T++ L S + +
Sbjct: 1574 LSGVQAELALQEESVRRSERER-----RATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 637 GSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALG 679
K + +L +V S+ + L + E E+ ++ LG
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG 1671
Score = 67.0 bits (162), Expect = 6e-11
Identities = 147/755 (19%), Positives = 310/755 (41%), Gaps = 102/755 (13%)
Query: 5 ESSQNTLRLQFKAMQEMQHKR--LQKQMEKKREK-ELSLKSRADDQEEPLEVSDGLSLLH 61
E+SQ+ L K + + + +R L++Q+++ R+K + ++++ D Q E + LL
Sbjct: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS 602
Query: 62 AGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRF- 120
+ N +S + V + + E LR E + L+ E++ + ++EE++
Sbjct: 603 REKSNLAHSLQ--VAQQQAEELRQEREK-----------LQAAQEELRRQRDRLEEEQED 649
Query: 121 AFTGTAGVAGDVVAT--KIVELSKKNRLL---MAESEGAKTRVKQLTNRIQELERELQTA 175
A A V ++ + ++ +L K +L + E A +R + +Q + E+ A
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 176 LTRLSAKGATDAGAKPPRAQMGDRALLET-PEVKALQDRLVATNLKMSDLRNQIQSVKQE 234
LT+ A G + + + + +L ++ ++ AL + L L ++ L Q++ K
Sbjct: 710 LTKAEA-GRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768
Query: 235 LRMAQKVLAREVG---------EDINVQQLLSSPG----------TWRGRAQQILVLQSK 275
L+ Q+ +E E++ ++Q ++ G QQ+ L+ +
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 276 VQELEKQLGQARSQSAGTASD------ELSVYPDPRKLSAQEKNLL---------RIRSL 320
+L++QL Q Q +G + E + + +A+EK L ++ +
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888
Query: 321 EREKQ---EGLEKLASERDVLQRELEELKKKFEGMRSRNK--------------LLSSEM 363
ERE + E +L E++ L+ L E++++ + +R + L+ E+
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
Query: 364 KTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQ----EEKTRVSQHHLD--- 416
L+ Q+ EK D EL+ + Q + +E SL Q EE + Q +
Sbjct: 949 AGLRQQIIATQEKASLDKELMAQKLVQAE--REAQASLREQRAAHEEDLQRLQREKEAAW 1006
Query: 417 QQLNSE-AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSP 475
++L +E AQ + L + + ++A EA+ +L EI L R++G+ S ++ +
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQQAL 1064
Query: 476 AYTQFLEDPGLTKSPASAGDHVGRLG--------SSRSVTSLGHTLVESALTRPSLPSPH 527
+ + E L++ + + ++S + V + +
Sbjct: 1065 SLKE-SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQ 1123
Query: 528 RTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK 587
R + + E + Q Q ++ + E + L + +L+ + +LLE++RK
Sbjct: 1124 REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRK 1183
Query: 588 LQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHN------PTGSEKK 641
L+E + V Q ++R G+ + + A R+ L ++ + +E K
Sbjct: 1184 LRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243
Query: 642 DPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKA 676
+ A L + E R +Q E L+A
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA 1278
Score = 60.5 bits (145), Expect = 5e-09
Identities = 77/354 (21%), Positives = 148/354 (41%), Gaps = 50/354 (14%)
Query: 131 DVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDA--- 187
D + T+ L+++ + AE + A +R +QL + E E ++ RLS A A
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE 1585
Query: 188 -----GAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVL 242
+ RA + A LE ++A + L A+ K+S ++ ++ + R ++VL
Sbjct: 1586 ESVRRSERERRATLDQVATLER-SLQATESELRASQEKISKMKANETKLEGDKRRLKEVL 1644
Query: 243 AREVGEDINVQ--------QLLSSPGTWRGRAQQILVLQSKVQELEKQLGQAR------- 287
+ ++ +L S R Q LQ +V L++Q+ +
Sbjct: 1645 DASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQ 1704
Query: 288 -------------SQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASE 334
+S G D++ + S+ N R ++L +K L +
Sbjct: 1705 LTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK--ALTACEHD 1762
Query: 335 RDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQL 394
R VLQ L+ ++ R ++ L +++TL+ ++ L E R + E QL+QL
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL-ELQRVEAE------GQLQQL 1815
Query: 395 QEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 448
+E+L Q ++ + + Q+L E + + LQ +A+ EA+ R++E
Sbjct: 1816 REVL----RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE 1865
Score = 53.1 bits (126), Expect = 9e-07
Identities = 140/690 (20%), Positives = 272/690 (39%), Gaps = 131/690 (18%)
Query: 23 HKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLL---HAGEPNSK-NSFEKRVLED 78
++ L+ ++K + +SLK +D+E+ L + + AGE + E+ LE
Sbjct: 1219 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA 1278
Query: 79 --EIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTA-----GVAGD 131
E++ LR +++ EN RL + L E + ++ +E R G G A
Sbjct: 1279 RRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Query: 132 VVATKIVELSKKNRLLMAESEGA-KTRVKQLTNRIQELERELQTALTRLSAKGATDAGAK 190
V + ++++++ + E EG +TR ++L ++E + L A+
Sbjct: 1339 EVMRQELQVAQRK---LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAAR 1395
Query: 191 PPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRM------------- 237
A++G R + L+ L ++ Q+ ++ LR
Sbjct: 1396 AEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPR 1455
Query: 238 ------AQKVLAREVGEDINVQQLLS-SPGTW--------------------RGRAQQIL 270
A+ A GE +N L SPG+ RG ++ L
Sbjct: 1456 PVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFL 1515
Query: 271 V-----------LQSKVQELEKQLGQARS------------QSAGTASDELSVYPDPRKL 307
L+++ L +QL + + Q A S+E D R
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575
Query: 308 SAQEKNLLR---IRSLEREKQEGLEKLASERDVLQRELEELK---KKFEGMRSRNKLLSS 361
Q + L+ +R ERE++ L+++A+ LQ EL+ +K M++ L
Sbjct: 1576 GVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEG 1635
Query: 362 EMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNS 421
+ + LK E++DA + +L+ SL + +++R+ + Q
Sbjct: 1636 DKRRLK--------------EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ--- 1678
Query: 422 EAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFL 481
AQ V LQ VA+ E K L++ + +LN L EG+ +V
Sbjct: 1679 -AQALQDRVDSLQRQVADSEVKAGTLQLTVERLN-GALAKVEESEGALRDKVR------- 1729
Query: 482 EDPGLTKSPASAGDHVG-----RLGSSRSVTSLGH--TLVESAL--TRPSLPSPHRTSPR 532
GLT++ A + + L +++T+ H +++ L R +L + S
Sbjct: 1730 ---GLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSS 1786
Query: 533 FSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEER 592
+ + + + +V++++ AE + +L E VL++R +E + L + +KLQ+ER
Sbjct: 1787 LGE--QVQTLRGEVADLELQRVEAEGQLQQLRE---VLRQR-QEGEAAALNTVQKLQDER 1840
Query: 593 HRTVVLEQHLEKIRLEPGKASASQRAAPRT 622
+L++ L ++ + A +R R+
Sbjct: 1841 R---LLQERLGSLQRALAQLEAEKREVERS 1867
Score = 48.9 bits (115), Expect = 2e-05
Identities = 137/673 (20%), Positives = 247/673 (36%), Gaps = 150/673 (22%)
Query: 37 ELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGR 96
EL+ SRA QE L +S GL L E ++ + EK+ L L+ +L E + +
Sbjct: 327 ELARTSRAV-QEAGLGLSTGLRL---AESRAEAALEKQAL------LQAQLEEQLRD--- 373
Query: 97 LYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKT 156
K+L+E+D + ++ +++ ++ ++ EL + L ++
Sbjct: 374 --KVLREKDLAQQQMQSDLDKAD-------------LSARVTELGLAVKRLEKQNLEKDQ 418
Query: 157 RVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRL-- 214
K LT +++ LE ++ ++A LET + + LQ L
Sbjct: 419 VNKDLTEKLEALES-----------------------LRLQEQAALETEDGEGLQQTLRD 455
Query: 215 -VATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ----- 268
L S+ Q+ ++ + L G+ SSPG RGR+ +
Sbjct: 456 LAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG--RGRSPRRGPSP 513
Query: 269 -------ILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLE 321
+ ++ S + + + Q+ R + AS +L L K L S
Sbjct: 514 ACSDSSTLALIHSALHKRQLQVQDMRGRYE--ASQDL--------LGTLRKQLSDSESER 563
Query: 322 REKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD 381
R +E L++L + D + E+ +++ + +RS N+LLS E L H
Sbjct: 564 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL-----------AHSL 612
Query: 382 ELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAERE 441
++ ++L+Q + EK + +Q L +Q + + V + E E
Sbjct: 613 QVAQQQAEELRQ----------EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
Query: 442 AKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLG 501
RQLE G+ +V L K + + R
Sbjct: 663 RSHRQLEQLEGKRSV-----------------------------LAKELVEVREALSRAT 693
Query: 502 SSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERD 561
R + V ALT+ E+ Q +S++ AL ++ ++
Sbjct: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Query: 562 RLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLE--------PGKAS 613
L V ++EE S L +R+ ++E ++ LE++RLE G
Sbjct: 754 DLNRLVA----QLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLR 809
Query: 614 ASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEM 673
+++A + LPT + + + S QLS E ++E+ QVE
Sbjct: 810 VAEQAQEALEQQLPTLRHERSQLQEQLAQLS-RQLSG--REQELEQARREAQRQVE---- 862
Query: 674 LKAALGSALRGKE 686
AL A R KE
Sbjct: 863 ---ALERAAREKE 872
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 69.3 bits (168), Expect = 1e-11
Identities = 120/554 (21%), Positives = 222/554 (40%), Gaps = 104/554 (18%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
+ + L Q +Q ++ +L+ +ME +R ++ K EE E
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEE------------ 1599
Query: 65 PNSKNSFEKRV------LEDEIEHLRNELRETVDENGRLYKL---LKERDFEIKHLKKKI 115
++ S +K++ LE+E E + LRE + G+L L + RDFE + +K
Sbjct: 1600 --ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK- 1656
Query: 116 EEDRFAFTGTAGVAGDVVATKIVELSKKNRLL--MAESEGAKTRVKQLTNRIQELERELQ 173
D+ TK + L+ +L + S +K + QL N+++E E
Sbjct: 1657 ---------------DLKRTKAL-LADAQLMLDHLKNSAPSKREIAQLKNQLEESEF--- 1697
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
T + A+ A + + Q+ D A +T AL+++L + ++++N+++ ++
Sbjct: 1698 TCAAAVKARKAMEVEIEDLHLQIDDIAKAKT----ALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 234 ELRMAQKV-------LAREVGEDINVQQLLSSPGTWRGRAQQIL-VLQSKVQELEKQLGQ 285
++ K +R++ + ++Q L + Q+ L LQS+V+ LE Q
Sbjct: 1754 DMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE----Q 1809
Query: 286 ARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEEL 345
+ + + E + +L + + R+ SL +E +EKL ERD QR E
Sbjct: 1810 SMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERD--QRIAAEN 1867
Query: 346 KKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQE 405
++K + R L QL+ +E +G L+ +E
Sbjct: 1868 REKEQNKR---------------------------------LQRQLRDTKEEMGELARKE 1894
Query: 406 EKTRVSQHHLDQQLNSEAQRSNSLVAQLQ---AMVAEREAKVRQLEMEIGQLNVHYLRNK 462
+ +H L+ L S + SL A L+ + + +A + EME + N + ++
Sbjct: 1895 AEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED-EMESDE-NEDLINSE 1952
Query: 463 GVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPS 522
G + S E+ K P+ A G L SS S TS +L
Sbjct: 1953 GDSDVDS--ELEDRVDGVKSWLSKNKGPSKAASDDGSLKSS-SPTSYWKSLAPDRSDDEH 2009
Query: 523 LPSPHRTSPRFSDS 536
P + + PR+S S
Sbjct: 2010 DPLDNTSRPRYSHS 2023
Score = 58.9 bits (141), Expect = 2e-08
Identities = 147/738 (19%), Positives = 284/738 (38%), Gaps = 140/738 (18%)
Query: 5 ESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGE 64
E +N LRL ++ + + +++ E + + + E L + L
Sbjct: 1274 EKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQY 1333
Query: 65 PNSKNSFEKRVLEDEIEHLR----NELRETVDENG-------RLYKLLKERDFEIKHLKK 113
K E V+E E+ R E+ VD++ + + ++E DF K L++
Sbjct: 1334 DALKKQME--VMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQ 1391
Query: 114 KIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQ 173
+ E+ +V +L ++ L A+SE ++ ++QL + Q L ELQ
Sbjct: 1392 EFEDKL-----------EVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ 1440
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSD--LRNQIQSV 231
T+L +G + + Q + L +A +++L L+ L + S+
Sbjct: 1441 D--TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSL 1498
Query: 232 KQELR--------MAQKVLAREVG-EDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQ 282
KQ+L QKV++ E +DI+ Q+ + + +Q+ L++KV++ E++
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVK-KQLRDLEAKVKDQEEE 1557
Query: 283 LGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQREL 342
L + AGT + +L + + + + S E E ++ E++ R Q++L
Sbjct: 1558 L----DEQAGTIQ---MLEQAKLRLEMEMERMRQTHSKEMESRD--EEVEEARQSCQKKL 1608
Query: 343 EELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEK-GRHDDELIDALMDQLKQLQEILGSL 401
++++ + E + + E + L+ ++ TL ++ R D E L LK+ + +L
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA 1668
Query: 402 SLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAERE------AKVRQ-LEMEIGQL 454
L LD NS + +AQL+ + E E K R+ +E+EI L
Sbjct: 1669 QLM----------LDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 455 NVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLV 514
+ L+ + K+ + + + RL R + + L
Sbjct: 1717 H-------------------------LQIDDIAKAKTALEEQLSRL--QREKNEIQNRLE 1749
Query: 515 ESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRV 574
E Q ++E+ +AA + R + LQ ++
Sbjct: 1750 ED--------------------------QEDMNELMKKHKAAVAQASRDLAQINDLQAQL 1783
Query: 575 EESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHN 634
EE+N + E + KLQ + + LEQ + ++ S + +T L +
Sbjct: 1784 EEANKEKQELQEKLQALQSQVEFLEQSM----VDKSLVSRQEAKIRELETRLEFERTQ-- 1837
Query: 635 PTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEM----------LKAALGSALRG 684
K+ S A +E EE R+A + E E K +G R
Sbjct: 1838 ----VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARK 1893
Query: 685 KEEDFRMYHEILGQVKSV 702
+ E R HE+ ++S+
Sbjct: 1894 EAEASRKKHELEMDLESL 1911
Score = 54.3 bits (129), Expect = 4e-07
Identities = 69/329 (20%), Positives = 143/329 (43%), Gaps = 46/329 (13%)
Query: 135 TKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRA 194
+K+ + K+ L S+ ++R+ +LT+ + + ++A L A+ A A+
Sbjct: 1268 SKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEK--- 1324
Query: 195 QMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQ 254
E+K LQ + A L+ Q++ ++ E+ A+ + A E+ +++
Sbjct: 1325 -----------EMKELQTQYDA-------LKKQMEVMEMEVMEARLIRAAEINGEVDDDD 1366
Query: 255 LLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNL 314
+ G WR + ++ + +V +K+L Q D+L V ++ E+ L
Sbjct: 1367 ---AGGEWRLKYERAV---REVDFTKKRLQQE-------FEDKLEVEQQNKR--QLERRL 1411
Query: 315 LRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV 374
+++ E Q L++L + L EL++ K EG + RN L + + S++
Sbjct: 1412 GDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAH 1471
Query: 375 EKGRHDDELIDALMDQLKQLQEILGSLSLQ-EEKTR---------VSQHHLDQQLNSEAQ 424
E+ + + + L + L SL Q EEK VS Q ++S+
Sbjct: 1472 EEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES 1531
Query: 425 RSNSLVAQLQAMVAEREAKVRQLEMEIGQ 453
+ + +A+++ + + EAKV+ E E+ +
Sbjct: 1532 KDEASLAKVKKQLRDLEAKVKDQEEELDE 1560
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 68.9 bits (167), Expect = 2e-11
Identities = 150/752 (19%), Positives = 302/752 (40%), Gaps = 134/752 (17%)
Query: 14 QFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSK---NS 70
+ +E K L+ Q+++ + LK +E + ++D S+L A E + N+
Sbjct: 1223 EISMQKEDDSKNLRNQLDRLSRENRDLK------DEIVRLND--SILQATEQRRRAEENA 1274
Query: 71 FEKRVLEDEI----EHLRNELRETV----DENGR-------LYKLLKERDFEIKHLKKKI 115
+++ EI +HL EL++ + ++N R K +++++ EI+ LK +
Sbjct: 1275 LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 116 EED---RFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
+E+ R+ + + +I+ L + E KT + QLT + +E
Sbjct: 1335 QEEAKRRWEYENELSKVRNNYDEEIISLKNQ---FETEINITKTTIHQLTMQKEEDTSGY 1391
Query: 173 QTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVK 232
+ + L+ + +R+L E E+K L++ L T +LR + ++
Sbjct: 1392 RAQIDNLTRE---------------NRSLSE--EIKRLKNTLTQTT---ENLRRVEEDIQ 1431
Query: 233 QELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL-----VLQSKVQELE--KQLGQ 285
Q+ +V R+ ++ ++Q+ R +Q L +Q K +E+E KQL
Sbjct: 1432 QQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLID 1491
Query: 286 ARSQSAGTASDE---------------LSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEK 330
+ DE S KL QE+ L R+R E+
Sbjct: 1492 KETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRI-------DYER 1544
Query: 331 LASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQ 390
++ ER V +++ + + ++ + + + E+ LK K + +E ++ +
Sbjct: 1545 VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRS 1604
Query: 391 LKQLQEILGSLSLQEEKTRV----SQHHLDQQ---LNSEAQRSNSLVAQLQAMVAEREAK 443
LK+ + +L+ Q E+ + S+ L QQ L+ + +L+ + +E EA
Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664
Query: 444 VRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSS 503
RQL E + +LRN+ + + +ED ++S + + RL S
Sbjct: 1665 RRQLLQEQESVKQAHLRNEH-------------FQKAIEDK--SRSLNESKIEIERLQSL 1709
Query: 504 RSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGW------QAQVS-----EIKAL 552
+ H ++E L L R ++ Q Q+S E++ L
Sbjct: 1710 TENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGL 1769
Query: 553 WQAAEVERDRLTEFVTVLQKRVEESNSKLLESERK----LQEERHRTV---VLEQ---HL 602
+ ER+ L + + QK+ E+++++ ES+ + +QE V VLEQ L
Sbjct: 1770 INDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARL 1829
Query: 603 EKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTT 662
+++ E +A ++ A R K L + ++ K S+ EE
Sbjct: 1830 QRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQ----------YSRKEEAIR 1879
Query: 663 RLAIQVEENEMLKAALGSALRGKEEDFRMYHE 694
++ + E++E K +L S + + + + E
Sbjct: 1880 KIESEREKSEREKNSLRSEIERLQAEIKRIEE 1911
Score = 55.5 bits (132), Expect = 2e-07
Identities = 140/750 (18%), Positives = 308/750 (41%), Gaps = 77/750 (10%)
Query: 1 MAADESSQNTLRLQF--KAMQEMQHK------RLQKQMEKKREKELSLKSRADDQEEPL- 51
+A D +S+N + +F + +Q+ Q + +L E KR+ EL KS + ++
Sbjct: 1043 LARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYG 1102
Query: 52 ---EVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNEL------RETVDENGRLYKL-- 100
E+++ ++ L + K ++ +ED + +N+ R+ EN KL
Sbjct: 1103 QIKELNEKITRLTYEIEDEKR--RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Query: 101 ---LKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTR 157
+KE+++EI+ L+ ++E+ V E+S E KT
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTT 1220
Query: 158 VKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVAT 217
+K+++ + ++ + L+ L RLS + + K ++ D L T + + ++
Sbjct: 1221 IKEISMQKEDDSKNLRNQLDRLSRE---NRDLKDEIVRLNDSILQATEQRRRAEENA--- 1274
Query: 218 NLKMSDLRNQIQSVKQELRMAQKVLAREVGEDI--NVQQLLSSPGTWRGRAQQILVLQSK 275
L+ ++I KQ L + K + ++ ED + Q L + T + + ++I L+++
Sbjct: 1275 -LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE 1333
Query: 276 VQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLR--IRSLEREKQEGLEKLAS 333
QE K+ + ++ + ++ + E N+ + I L +K+E +
Sbjct: 1334 FQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRA 1393
Query: 334 ERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQ 393
+ D L RE L ++ + +++ + ++ ++ + G + L +L+Q
Sbjct: 1394 QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Query: 394 LQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLV---AQLQAMVAEREAKVRQLEME 450
+ ++ S++ +++ Q N E +R L+ + + + A++++++ +
Sbjct: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD 1513
Query: 451 IGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDH-VGRLGSSRSVTSL 509
+ + N + + + T+ D + D + R +S L
Sbjct: 1514 LQKAN-----SSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQL 1568
Query: 510 GHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTV 569
VE L R + + R E +G + + E QA + +T
Sbjct: 1569 QKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-----QAIK---------ITN 1614
Query: 570 LQKRVEESNSKLLESERKLQEERHRTVVLEQHL-------EKIRLEPGKASASQRAAPRT 622
L +++E+++ SE L+++R VL+ HL E++R + A +R +
Sbjct: 1615 LTQQLEQASIVKKRSEDDLRQQRD---VLDGHLREKQRTQEELRRLSSEVEALRRQLLQE 1671
Query: 623 KTGLPTSN--NRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGS 680
+ + ++ N H E K S + S + +E +++ LT L +E+ ML+ L +
Sbjct: 1672 QESVKQAHLRNEHFQKAIEDKSRSLNE-SKIEIE-RLQSLTENL---TKEHLMLEEELRN 1726
Query: 681 ALRGKEEDFRMYHEILGQVKSVFLQALRQQ 710
LR + +D R K+ + LR Q
Sbjct: 1727 -LRLEYDDLRRGRSEADSDKNATILELRSQ 1755
Score = 52.4 bits (124), Expect = 1e-06
Identities = 88/417 (21%), Positives = 171/417 (41%), Gaps = 47/417 (11%)
Query: 6 SSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQ-------EEPLE------ 52
S + T++ Q + K LQ Q +K E+ LK A + EE LE
Sbjct: 1546 SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSL 1605
Query: 53 VSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLK 112
+ + + + + S K+ ED++ R+ L + E R + L+ E++ L+
Sbjct: 1606 KEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALR 1665
Query: 113 KKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELEREL 172
+++ +++ + A + + I + S+ E E ++ + LT LE EL
Sbjct: 1666 RQLLQEQESVK-QAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
Query: 173 QTALTRLS--AKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQS 230
+ +G ++A + + R+ L+ + L+ + L N +Q
Sbjct: 1725 RNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLE---------LQGLINDLQR 1775
Query: 231 VKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQS 290
++ LR + ++ E N Q + T + ++ L+++ KV E +K Q
Sbjct: 1776 ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1835
Query: 291 AGTASDELSVYPDPRKLSAQEK-----NLLRIRSLEREKQEGLEKLASERDVLQRELEEL 345
A L ++ EK +L + ++ K+E + K+ SER+ +RE L
Sbjct: 1836 LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSL 1895
Query: 346 KKKFEGM---------RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQ 393
+ + E + R R KL S +T +SQ+ T E+ R+ E+ D+L+Q
Sbjct: 1896 RSEIERLQAEIKRIEERCRRKLEDSTRET-QSQLET--ERSRYQREI-----DKLRQ 1944
Score = 42.4 bits (98), Expect = 0.002
Identities = 94/439 (21%), Positives = 169/439 (38%), Gaps = 75/439 (17%)
Query: 305 RKLSAQEKNL--LRIRSLEREKQEGLEKLA----SERDVLQRELEELKKKFEGMRSRNKL 358
R LS K+L L++++ + E E +LA SE + L++ +K++ S+ K
Sbjct: 1015 RFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA 1074
Query: 359 LSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLS--LQEEKTRVS--QHH 414
+ ++ LK Q G+ + +D Q+K+L E + L+ +++EK R +
Sbjct: 1075 KLASLEELKRQAEL---DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR 1131
Query: 415 LDQQLNSEAQRSNSL------------------------VAQLQAMVAEREAKVRQLEME 450
DQQ N Q + + +L+ ++ E + R+ E E
Sbjct: 1132 FDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Query: 451 IGQLNVHY------LRNKGVGEGSSGREVSPAYTQFLEDPG---------LTKSPASAGD 495
+ ++ HY LRNK E + + + ED L++ D
Sbjct: 1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD 1251
Query: 496 HVGRLGSS-RSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQ 554
+ RL S T E+AL + + S QK ++ E+K + Q
Sbjct: 1252 EIVRLNDSILQATEQRRRAEENALQQKACGSEIM----------QKKQHLEI-ELKQVMQ 1300
Query: 555 AAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASA 614
+ R + + K +++ N ++ + + QEE R E L K+R +
Sbjct: 1301 QRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEII 1360
Query: 615 SQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEML 674
S + T+ + T H T +++D S +Q++ LT EE + L
Sbjct: 1361 SLKNQFETEINI-TKTTIHQLTMQKEEDTS-------GYRAQIDNLTRENRSLSEEIKRL 1412
Query: 675 KAALGSA---LRGKEEDFR 690
K L LR EED +
Sbjct: 1413 KNTLTQTTENLRRVEEDIQ 1431
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 68.9 bits (167), Expect = 2e-11
Identities = 135/637 (21%), Positives = 258/637 (40%), Gaps = 58/637 (9%)
Query: 25 RLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNS--KNSFEKRVLEDEIEH 82
+++K+++++ E+ L++ +E + +L + G S + K+V + +E
Sbjct: 894 KIRKELDEETERRRQLENEVKSTQEEI-----WTLRNQGPQESVVRKEVLKKVPDPVLEE 948
Query: 83 LRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVV--------A 134
+L+ T+ E +LL+E + E L+ + E G V +V+ A
Sbjct: 949 SFQQLQRTLAEEQHKNQLLQE-ELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQA 1007
Query: 135 TKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRA 194
++++L ++ L + + V L R+ L E A +++ K P
Sbjct: 1008 DEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL- 1066
Query: 195 QMGDRALLETPEVKALQDRL-VATNLKMSDLRNQIQSVKQELRMAQ-KVLAREV---GED 249
+ + E QD+L ++S L+++++ +++E MA+ K+ +EV +D
Sbjct: 1067 ---EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKD 1123
Query: 250 INVQQLLSS-PGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELS---VYPDPR 305
++ +S + A + Q + EL +++ ++A E V PDP+
Sbjct: 1124 AATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPK 1183
Query: 306 KLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKT 365
S L + ER+ + E+L S Q ELE L+++ G + K ++ E+
Sbjct: 1184 AESEVANLRLELVEQERKYRGAEEQLRS----YQSELEALRRR--GPQVEVKEVTKEVIK 1237
Query: 366 LKSQMGTLVEKGRHDDELIDAL---------MDQLKQLQEILGSLSLQEEKTRVSQHHLD 416
K+ E R +E++D + QLK+ + L Q + V Q L
Sbjct: 1238 YKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQ 1297
Query: 417 QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPA 476
Q E ++ VA L+A ++E + K LE E R + R V
Sbjct: 1298 FQ---EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQE 1354
Query: 477 YTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDS 536
++ E+PGL ++ + + R + L L R L R +
Sbjct: 1355 VVRYEEEPGLRAEASAFAESIDV--ELRQIDKLRAELRRLQRRRTELERQLEELER--ER 1410
Query: 537 PEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESER----KLQEER 592
++ + +V ++ A E E E VT QK V + + + +L+EE+
Sbjct: 1411 QARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQ 1470
Query: 593 HRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTS 629
HR +LE LE +R K +A ++A + K L S
Sbjct: 1471 HRRQLLEGELETLR---RKLAALEKAEVKEKVVLSES 1504
Score = 56.6 bits (135), Expect = 8e-08
Identities = 104/499 (20%), Positives = 216/499 (43%), Gaps = 71/499 (14%)
Query: 8 QNTLRLQFKAMQEMQHKRLQKQMEKKREKELS--------LKSRADDQEEPLEVSDGLSL 59
QN +L+ + Q + + Q Q+ +K+E+ELS L+ E + V + L +
Sbjct: 1061 QNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKV 1120
Query: 60 LHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEI--KHLKKKIEE 117
+ S R EDE R RE + +++ L +E + + +++ +
Sbjct: 1121 EKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRP 1180
Query: 118 DRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESE-------GAKTRVKQLTNRI----- 165
D A + A + ++V + + +L +SE G + VK++T +
Sbjct: 1181 DPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT 1240
Query: 166 -QELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLE----TPEVKALQDR--LVATN 218
E+E+ELQ + K ++ +R LE E++AL+D V T
Sbjct: 1241 DPEMEKELQRLREEIVDK-----------TRLIERCDLEIYQLKKEIQALKDTKPQVQTK 1289
Query: 219 LKMSDLR--NQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQIL------ 270
+ ++ + K+E+ + L+ E + +++++ +S R ++ L
Sbjct: 1290 EVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKER 1349
Query: 271 VLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRS-LEREKQEGLE 329
V+Q +V E++ G SA S ++ + KL A+ + L R R+ LER+ +E LE
Sbjct: 1350 VVQQEVVRYEEEPGLRAEASAFAESIDVEL-RQIDKLRAELRRLQRRRTELERQLEE-LE 1407
Query: 330 KLASERDVLQRELEELKKKF-----EGMRSRNKLLSSEMKTLKSQ---------MGTLVE 375
+ R +RE++ L+++ E +R K+ ++ L+ + +E
Sbjct: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLE 1467
Query: 376 KGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQA 435
+ +H +L++ +L+ L+ L +L E K +V L + + E + + +L++
Sbjct: 1468 EEQHRRQLLEG---ELETLRRKLAALEKAEVKEKVV---LSESVQVEKGDTEQEIQRLKS 1521
Query: 436 MVAEREAKVRQLEMEIGQL 454
+ E R+L++E+ +L
Sbjct: 1522 SLEEESRSKRELDVEVSRL 1540
Score = 37.4 bits (85), Expect = 0.049
Identities = 95/497 (19%), Positives = 193/497 (38%), Gaps = 83/497 (16%)
Query: 142 KKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRAL 201
++ R + +E AK +K +TN + +E E TR +A+G A P G L
Sbjct: 534 EQGRAVQDSAERAKD-LKNITNELLRIEPEK----TRSTAEGEAFIQALPGS---GTTPL 585
Query: 202 LETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGT 261
L T R+ TN K L + ++++ +A ++ + ++QQ T
Sbjct: 586 LRT--------RVEDTNRKYEHLLQLLDLAQEKVDVANRL-------EKSLQQSWELLAT 630
Query: 262 WRGRAQQ-------ILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNL 314
Q VL SK QEL + ++Q + L E+NL
Sbjct: 631 HENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKS--------------LLGEVEQNL 676
Query: 315 LRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLV 374
+ ++ + + + E+ +L ++F +R + + ++L+S
Sbjct: 677 QAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQ---VERRAQSLQSAKAAYE 733
Query: 375 EKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQ 434
R D ++ L+ + SLS E K + ++ LD+ + E + V ++
Sbjct: 734 HFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQE-----VQKIC 788
Query: 435 AMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAG 494
A + + V+ E+E +L + + + +GR + L+ P TK
Sbjct: 789 ANSQQYQQAVKDYELEAEKL-------RSLLDLENGRSSHVSKRARLQSPA-TKVKEEEA 840
Query: 495 DHVGRLGSSRSVTSLGHTLVESALT----RPSLPSPHRTSPR-FSDSPEQKGWQAQ---- 545
+ ++ +E AL +P + H T R DS ++ W+ +
Sbjct: 841 ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD 900
Query: 546 ---------VSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLES-----ERKLQEE 591
+E+K+ + R++ + V ++ +++ +LE +R L EE
Sbjct: 901 EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE 960
Query: 592 RHRTVVLEQHLEKIRLE 608
+H+ +L++ LE ++L+
Sbjct: 961 QHKNQLLQEELEALQLQ 977
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/472 (21%), Positives = 188/472 (39%), Gaps = 125/472 (26%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREK-------ELSLKSRADDQEEPLEV 53
MA + + L + KA+QE H++ ++ + +K ++ L+ + DD E LE
Sbjct: 988 MAGLDETIAKLTKEKKALQEA-HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 54 SDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKK 113
L + KR LE +++ + + + +E +L + LK+++FEI +L+
Sbjct: 1047 EKKLRM--------DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 114 KIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQ 173
KIE+++ ++L KK +K+L RI+ELE E++
Sbjct: 1099 KIEDEQALG---------------IQLQKK--------------IKELQARIEELEEEIE 1129
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
A+ A+ A A+ R SDL +++ + +
Sbjct: 1130 -------AERASRAKAEKQR----------------------------SDLSRELEEISE 1154
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT 293
L A + ++ ++N ++ +++ Q++ + L +A Q T
Sbjct: 1155 RLEEAGGATSAQI--EMNKKR------------------EAEFQKMRRDLEEATLQHEAT 1194
Query: 294 ASDELSVYPDP-RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGM 352
A+ + D +L Q NL R++ +KL E+ ++ E+++L E +
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVK----------QKLEKEKSEMKMEIDDLASNVETV 1244
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLS--LQEEKTRV 410
L +TL+ Q+ L K LI+ L Q +LQ G S L E++ V
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 411 SQ------------HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME 450
SQ L +QL E + N+L LQ+ + + Q E E
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Score = 62.4 bits (150), Expect = 1e-09
Identities = 107/464 (23%), Positives = 189/464 (40%), Gaps = 61/464 (13%)
Query: 27 QKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNS----------------KNS 70
Q +M KKRE E K R D +E L+ + L +S K
Sbjct: 1166 QIEMNKKREAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 71 FEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAG 130
EK ++ EI+ L + + G L K+ + + ++ LK K EE + G
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 131 DVVATK---IVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDA 187
+ +L +K L+ S G + T +I+EL+R+L+ + A +A
Sbjct: 1285 RLQTESGEFSRQLDEKEALVSQLSRGKQA----FTQQIEELKRQLEEEIK------AKNA 1334
Query: 188 GAKPPRAQMGDRALL-----ETPEVKA-LQDRLVATNLKMSDLRNQIQSVK----QELRM 237
A ++ D LL E E KA LQ L N +++ R + ++ +EL
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE 1394
Query: 238 AQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASD 296
A+K LA+ + + +V+ + + + Q+ LQ++V++L L R+ +A A D
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---LQNEVEDL--MLDVERTNAACAALD 1449
Query: 297 ELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRN 356
+K +K L + E LE E L EL ++K +E +
Sbjct: 1450 --------KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 357 KLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLD 416
+ L E K L+ ++ L E+ + I L KQ+++ L E+ S H
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH-- 1559
Query: 417 QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E + + +L + +E + K+ + + EI QL +++R
Sbjct: 1560 -----EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Score = 47.8 bits (112), Expect = 4e-05
Identities = 106/552 (19%), Positives = 217/552 (39%), Gaps = 74/552 (13%)
Query: 167 ELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRN 226
E E+E+ T A ++ R ++ ++ + E LQ ++ A ++D
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 227 QI-QSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRA--QQILVLQSKVQELEKQL 283
+ Q +K ++++ K+ +EV E ++ +++ T + R + L+ + +LE L
Sbjct: 910 RCDQLIKTKIQLEAKI--KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 284 GQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIR-SLEREKQEGLEKLASERDVLQR-- 340
+ + T + ++ + L L + + +L+ Q+ L+ L +E D +
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 341 ----ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQE 396
+LE+ EG + K L +++ K ++ ++ + +++MD + Q+
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ------ESIMDIENEKQQ 1081
Query: 397 ILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNV 456
+ +EK + + + L S+ + +L QLQ + E +A++ +LE EI
Sbjct: 1082 L-------DEKLKKKEFEISN-LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 457 HYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVES 516
R K + S ++ LE+ G S + + L ++
Sbjct: 1134 S--RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 517 ALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVE- 575
T +L H +DS + G Q+ ++ + Q E E+ + + L VE
Sbjct: 1192 EATAATLRKKH------ADSVAELG--EQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET 1243
Query: 576 --------ESNSKLLE---SERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKT 624
E + LE SE K +EE + ++ + ++ RL+ S++
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL------ 1297
Query: 625 GLPTSNNRHNPTGSEKKDPSFAQLS--DVPVESQMEELTTRLAIQVEENEMLKAALGSAL 682
++K+ +QLS Q+EEL Q+EE K AL AL
Sbjct: 1298 --------------DEKEALVSQLSRGKQAFTQQIEELKR----QLEEEIKAKNALAHAL 1339
Query: 683 RGKEEDFRMYHE 694
+ D + E
Sbjct: 1340 QSSRHDCDLLRE 1351
Score = 44.3 bits (103), Expect = 4e-04
Identities = 84/493 (17%), Positives = 204/493 (41%), Gaps = 36/493 (7%)
Query: 2 AADESSQNTLRL--QFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSL 59
A D+ +N ++ ++K E H L+ ++ R L + EE L+ + L
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 60 LHAGEPNSKNSFEKRVLED--EIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEE 117
+ + +++ E I L ++ E L L+E + ++H + KI
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 118 DRFAFTGTAGVAGDVVATKIVELS--KKNRLLMAES------------EGAKTRVKQLTN 163
+ +A K E+ K+N + + ES A K++
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 164 RIQELERELQTALTRLSAKGA-----TDAGAKPPRAQMGD--RALLETPEVKALQDRLVA 216
+ E+E +L A R++A+ T K + + D R+ + E A+ +R
Sbjct: 1627 DLNEMEIQLNHA-NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER--R 1683
Query: 217 TNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-----ILV 271
NL +++ ++++ ++ ++K+ +E+ + QLL + T ++ I
Sbjct: 1684 ANLLQAEIE-ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
+Q +++++ ++ A ++ +D + + +K +L R++ + + L+
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQL 391
E + Q L+ KK+ + + +R + L E+++ + + V+ R + + L Q
Sbjct: 1803 LDEAE--QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQT 1860
Query: 392 KQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEI 451
++ ++ + L +K + +Q ++SN+ +A+ + + E E + ++
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920
Query: 452 GQLNVHYLRNKGV 464
Q+N ++++ V
Sbjct: 1921 SQVNKLRVKSREV 1933
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/472 (21%), Positives = 188/472 (39%), Gaps = 125/472 (26%)
Query: 1 MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREK-------ELSLKSRADDQEEPLEV 53
MA + + L + KA+QE H++ ++ + +K ++ L+ + DD E LE
Sbjct: 988 MAGLDETIAKLTKEKKALQEA-HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 54 SDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKK 113
L + KR LE +++ + + + +E +L + LK+++FEI +L+
Sbjct: 1047 EKKLRM--------DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 114 KIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQ 173
KIE+++ ++L KK +K+L RI+ELE E++
Sbjct: 1099 KIEDEQALG---------------IQLQKK--------------IKELQARIEELEEEIE 1129
Query: 174 TALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQ 233
A+ A+ A A+ R SDL +++ + +
Sbjct: 1130 -------AERASRAKAEKQR----------------------------SDLSRELEEISE 1154
Query: 234 ELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT 293
L A + ++ ++N ++ +++ Q++ + L +A Q T
Sbjct: 1155 RLEEAGGATSAQI--EMNKKR------------------EAEFQKMRRDLEEATLQHEAT 1194
Query: 294 ASDELSVYPDP-RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGM 352
A+ + D +L Q NL R++ +KL E+ ++ E+++L E +
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVK----------QKLEKEKSEMKMEIDDLASNVETV 1244
Query: 353 RSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLS--LQEEKTRV 410
L +TL+ Q+ L K LI+ L Q +LQ G S L E++ V
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 411 SQ------------HHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME 450
SQ L +QL E + N+L LQ+ + + Q E E
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Score = 62.4 bits (150), Expect = 1e-09
Identities = 107/464 (23%), Positives = 189/464 (40%), Gaps = 61/464 (13%)
Query: 27 QKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNS----------------KNS 70
Q +M KKRE E K R D +E L+ + L +S K
Sbjct: 1166 QIEMNKKREAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 71 FEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAG 130
EK ++ EI+ L + + G L K+ + + ++ LK K EE + G
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 131 DVVATK---IVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDA 187
+ +L +K L+ S G + T +I+EL+R+L+ + A +A
Sbjct: 1285 RLQTESGEFSRQLDEKEALVSQLSRGKQA----FTQQIEELKRQLEEEIK------AKNA 1334
Query: 188 GAKPPRAQMGDRALL-----ETPEVKA-LQDRLVATNLKMSDLRNQIQSVK----QELRM 237
A ++ D LL E E KA LQ L N +++ R + ++ +EL
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE 1394
Query: 238 AQKVLAREV-GEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASD 296
A+K LA+ + + +V+ + + + Q+ LQ++V++L L R+ +A A D
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---LQNEVEDL--MLDVERTNAACAALD 1449
Query: 297 ELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRN 356
+K +K L + E LE E L EL ++K +E +
Sbjct: 1450 --------KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 357 KLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLD 416
+ L E K L+ ++ L E+ + I L KQ+++ L E+ S H
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH-- 1559
Query: 417 QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLR 460
E + + +L + +E + K+ + + EI QL +++R
Sbjct: 1560 -----EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Score = 47.8 bits (112), Expect = 4e-05
Identities = 106/552 (19%), Positives = 217/552 (39%), Gaps = 74/552 (13%)
Query: 167 ELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRN 226
E E+E+ T A ++ R ++ ++ + E LQ ++ A ++D
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 227 QI-QSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRA--QQILVLQSKVQELEKQL 283
+ Q +K ++++ K+ +EV E ++ +++ T + R + L+ + +LE L
Sbjct: 910 RCDQLIKTKIQLEAKI--KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 284 GQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIR-SLEREKQEGLEKLASERDVLQR-- 340
+ + T + ++ + L L + + +L+ Q+ L+ L +E D +
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 341 ----ELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQE 396
+LE+ EG + K L +++ K ++ ++ + +++MD + Q+
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ------ESIMDIENEKQQ 1081
Query: 397 ILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNV 456
+ +EK + + + L S+ + +L QLQ + E +A++ +LE EI
Sbjct: 1082 L-------DEKLKKKEFEISN-LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 457 HYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVES 516
R K + S ++ LE+ G S + + L ++
Sbjct: 1134 S--RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 517 ALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVE- 575
T +L H +DS + G Q+ ++ + Q E E+ + + L VE
Sbjct: 1192 EATAATLRKKH------ADSVAELG--EQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET 1243
Query: 576 --------ESNSKLLE---SERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKT 624
E + LE SE K +EE + ++ + ++ RL+ S++
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL------ 1297
Query: 625 GLPTSNNRHNPTGSEKKDPSFAQLS--DVPVESQMEELTTRLAIQVEENEMLKAALGSAL 682
++K+ +QLS Q+EEL Q+EE K AL AL
Sbjct: 1298 --------------DEKEALVSQLSRGKQAFTQQIEELKR----QLEEEIKAKNALAHAL 1339
Query: 683 RGKEEDFRMYHE 694
+ D + E
Sbjct: 1340 QSSRHDCDLLRE 1351
Score = 44.3 bits (103), Expect = 4e-04
Identities = 84/493 (17%), Positives = 204/493 (41%), Gaps = 36/493 (7%)
Query: 2 AADESSQNTLRL--QFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSL 59
A D+ +N ++ ++K E H L+ ++ R L + EE L+ + L
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 60 LHAGEPNSKNSFEKRVLED--EIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEE 117
+ + +++ E I L ++ E L L+E + ++H + KI
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 118 DRFAFTGTAGVAGDVVATKIVELS--KKNRLLMAES------------EGAKTRVKQLTN 163
+ +A K E+ K+N + + ES A K++
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 164 RIQELERELQTALTRLSAKGA-----TDAGAKPPRAQMGD--RALLETPEVKALQDRLVA 216
+ E+E +L A R++A+ T K + + D R+ + E A+ +R
Sbjct: 1627 DLNEMEIQLNHA-NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER--R 1683
Query: 217 TNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQ-----ILV 271
NL +++ ++++ ++ ++K+ +E+ + QLL + T ++ I
Sbjct: 1684 ANLLQAEIE-ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 272 LQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKL 331
+Q +++++ ++ A ++ +D + + +K +L R++ + + L+
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 332 ASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQL 391
E + Q L+ KK+ + + +R + L E+++ + + V+ R + + L Q
Sbjct: 1803 LDEAE--QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQT 1860
Query: 392 KQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEI 451
++ ++ + L +K + +Q ++SN+ +A+ + + E E + ++
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920
Query: 452 GQLNVHYLRNKGV 464
Q+N ++++ V
Sbjct: 1921 SQVNKLRVKSREV 1933
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,146,572
Number of Sequences: 37866
Number of extensions: 1095908
Number of successful extensions: 12472
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 239
Number of HSP's successfully gapped in prelim test: 867
Number of HSP's that attempted gapping in prelim test: 6797
Number of HSP's gapped (non-prelim): 4220
length of query: 715
length of database: 18,247,518
effective HSP length: 109
effective length of query: 606
effective length of database: 14,120,124
effective search space: 8556795144
effective search space used: 8556795144
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.