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Search of human proteins with 153792305
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
(371 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 735 0.0
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 119 4e-27
gi|61742786 leucine rich repeat and death domain containing prot... 110 3e-24
gi|61742784 leucine rich repeat and death domain containing prot... 110 3e-24
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 101 1e-21
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 100 2e-21
gi|61742782 leucine rich repeat and death domain containing prot... 97 2e-20
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 96 7e-20
gi|24308207 leucine rich repeat containing 47 [Homo sapiens] 95 9e-20
gi|238908508 leucine-rich repeat and death domain-containing pro... 94 3e-19
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 94 3e-19
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 92 6e-19
gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isofor... 92 1e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 91 1e-18
gi|45827729 scribble isoform b [Homo sapiens] 90 4e-18
gi|45827731 scribble isoform a [Homo sapiens] 90 4e-18
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 89 8e-18
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 88 1e-17
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 88 1e-17
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 85 9e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 84 2e-16
gi|197333706 leucine rich repeat containing 8 family, member D [... 83 5e-16
gi|34222199 leucine rich repeat containing 8 family, member D [H... 83 5e-16
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 83 5e-16
gi|4503743 flightless I homolog [Homo sapiens] 82 6e-16
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 82 8e-16
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom... 81 1e-15
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 81 1e-15
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 81 2e-15
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 81 2e-15
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 735 bits (1898), Expect = 0.0
Identities = 371/371 (100%), Positives = 371/371 (100%)
Query: 1 MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLP 60
MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLP
Sbjct: 1 MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLP 60
Query: 61 RALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCR 120
RALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCR
Sbjct: 61 RALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCR 120
Query: 121 SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180
SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE
Sbjct: 121 SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180
Query: 181 IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEEL 240
IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEEL
Sbjct: 181 IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEEL 240
Query: 241 SLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPK 300
SLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPK
Sbjct: 241 SLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPK 300
Query: 301 CGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASV 360
CGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASV
Sbjct: 301 CGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASV 360
Query: 361 AARRMQKVLLG 371
AARRMQKVLLG
Sbjct: 361 AARRMQKVLLG 371
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 119 bits (298), Expect = 4e-27
Identities = 90/240 (37%), Positives = 121/240 (50%), Gaps = 24/240 (10%)
Query: 30 SELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLA 89
+ L A G E A L +L L HN+L +LP LG+ HL+ LDVS N L L L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDSLSC 179
Query: 90 LRGLRTLLAKNNRLGGPSALPKGLAQS--------------------PLCRSLQVLNLSG 129
L LRTL +N+L +A P+ L Q R+L++L LSG
Sbjct: 180 LSRLRTLDVDHNQL---TAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
Query: 130 NCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
+PA EL +L++L L N LQ++PA+ LQ L+ L L N +E P L L
Sbjct: 237 AELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
Query: 190 SLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVV 249
L L L N++ S+P +S L L +L L NN + YLP I+ L LEEL L+GN + V
Sbjct: 297 GLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAV 356
Score = 104 bits (260), Expect = 1e-22
Identities = 85/234 (36%), Positives = 117/234 (50%), Gaps = 18/234 (7%)
Query: 32 LEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELL-AL 90
LE E A +L L+L NR LP A+ HL LDVS N LTALG E++ AL
Sbjct: 75 LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSAL 134
Query: 91 RGLRTLLAKNNRLGGPSALPKGLA----------------QSPLCRS-LQVLNLSGNCFQ 133
R LR L +N+L A LA S C S L+ L++ N
Sbjct: 135 RELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLT 194
Query: 134 EVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNY 193
P LL+L AL+ L + N+L+ +P +I L++L+ L+L G + +P L SL
Sbjct: 195 AFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLES 254
Query: 194 LVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
L+L +N +Q++P Q S L L+ L+L +NL P +L L LEEL L N L
Sbjct: 255 LMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQL 308
Score = 96.3 bits (238), Expect = 4e-20
Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 33/237 (13%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG- 104
L L + HN+L + PR L L+ LDVS N L L ++ ALR L+ L LG
Sbjct: 183 LRTLDVDHNQLTAFPRQLLQ-LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGT 241
Query: 105 -------------------GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRAL 145
G ALP AQ + L++LNLS N F+E PA+LL L L
Sbjct: 242 LPAGFCELASLESLMLDNNGLQALP---AQFSCLQRLKMLNLSSNLFEEFPAALLPLAGL 298
Query: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIP 205
+ L L NQL S+P+ I L L L+L N I+ +P + L L LVL N+I +P
Sbjct: 299 EELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLP 358
Query: 206 PQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTL 262
QL + + +N L P E+ ++G P + + ++L + P +
Sbjct: 359 DHFGQLSRVGLWKIKDNPLIQPPYEV---------CMKGIPYIAAYQKELAHSQPAV 406
Score = 63.5 bits (153), Expect = 3e-10
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 26/152 (17%)
Query: 122 LQVLNLSGNCFQEVPASL---------LELRA----------------LQTLSLGGNQLQ 156
++ LNL N +EVP L L LR L L + N+L
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 157 SIPAEIEN-LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLR 215
++ AE+ + L+ L L L N + +P +LG L L L + N++ +P LS L LR
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 216 SLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
+L + +N LT PR++L L+ LEEL + N L
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRL 216
Score = 52.0 bits (123), Expect = 9e-07
Identities = 35/87 (40%), Positives = 52/87 (59%), Gaps = 3/87 (3%)
Query: 164 NLQSLECLYLGGNFIKEIPPELGN-LPSLNYLVLCDNKIQSIPPQLSQL-HSLRSLSLHN 221
NL +E L LG N ++E+P LG+ L SL LVL N+ +PP +++L H L L + +
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 222 NLLTYLPREILN-LIHLEELSLRGNPL 247
N LT L E+++ L L +L+L N L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQL 147
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 110 bits (274), Expect = 3e-24
Identities = 91/250 (36%), Positives = 122/250 (48%), Gaps = 44/250 (17%)
Query: 15 ELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLD 74
E ++L S L S L +G +RR A LR L +LP L SG HL LD
Sbjct: 79 EATLAQLPQSLSCLRS-LVLKGGQRRDTLGACLR-----GALTNLPAGL-SGLAHLAHLD 131
Query: 75 VSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQE 134
+S N+L L +L +RGL LL LS NC E
Sbjct: 132 LSFNSLETLPACVLQMRGLGALL-----------------------------LSHNCLSE 162
Query: 135 VPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYL 194
+P +L L AL L++ N+LQ++P + L +L+ L L N + +PPE+G L SL L
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 195 VLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRD 254
L N++QS+P L+ L SLR L LH+NLL +P ++ L L L LR N L RD
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL-----RD 277
Query: 255 LTYDPPTLLE 264
L PP LL+
Sbjct: 278 L---PPELLD 284
Score = 78.6 bits (192), Expect = 9e-15
Identities = 68/171 (39%), Positives = 88/171 (51%), Gaps = 12/171 (7%)
Query: 19 SRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGN 78
+ L +S +LE+ L A + RG L LLL HN L LP ALG+ P L L V+ N
Sbjct: 128 AHLDLSFNSLET-LPACVLQMRG----LGALLLSHNCLSELPEALGA-LPALTFLTVTHN 181
Query: 79 ALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPAS 138
L L P L AL L+ L N L GL SL LNL+ N Q +PAS
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------SLLELNLASNRLQSLPAS 235
Query: 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
L LR+L+ L L N L S+PA++ L L L L N ++++PPEL + P
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 110 bits (274), Expect = 3e-24
Identities = 91/250 (36%), Positives = 122/250 (48%), Gaps = 44/250 (17%)
Query: 15 ELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLD 74
E ++L S L S L +G +RR A LR L +LP L SG HL LD
Sbjct: 79 EATLAQLPQSLSCLRS-LVLKGGQRRDTLGACLR-----GALTNLPAGL-SGLAHLAHLD 131
Query: 75 VSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQE 134
+S N+L L +L +RGL LL LS NC E
Sbjct: 132 LSFNSLETLPACVLQMRGLGALL-----------------------------LSHNCLSE 162
Query: 135 VPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYL 194
+P +L L AL L++ N+LQ++P + L +L+ L L N + +PPE+G L SL L
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 195 VLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRD 254
L N++QS+P L+ L SLR L LH+NLL +P ++ L L L LR N L RD
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL-----RD 277
Query: 255 LTYDPPTLLE 264
L PP LL+
Sbjct: 278 L---PPELLD 284
Score = 78.6 bits (192), Expect = 9e-15
Identities = 68/171 (39%), Positives = 88/171 (51%), Gaps = 12/171 (7%)
Query: 19 SRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGN 78
+ L +S +LE+ L A + RG L LLL HN L LP ALG+ P L L V+ N
Sbjct: 128 AHLDLSFNSLET-LPACVLQMRG----LGALLLSHNCLSELPEALGA-LPALTFLTVTHN 181
Query: 79 ALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPAS 138
L L P L AL L+ L N L GL SL LNL+ N Q +PAS
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------SLLELNLASNRLQSLPAS 235
Query: 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
L LR+L+ L L N L S+PA++ L L L L N ++++PPEL + P
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 101 bits (251), Expect = 1e-21
Identities = 83/249 (33%), Positives = 119/249 (47%), Gaps = 54/249 (21%)
Query: 45 ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG 104
AL L + N+L SLP A+ +LQ L+VS N L L E+ LR L+ L ++N L
Sbjct: 106 ALTVLDIHDNQLTSLPSAIRE-LENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL- 163
Query: 105 GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIEN 164
+ + +G Q +L+ L+LS N VPAS L +L L+L N+L+S+PAEI
Sbjct: 164 --TCISEGFEQ---LSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVL-------------C-------------- 197
++ L+ L N ++ IPPEL + SL L L C
Sbjct: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIE 278
Query: 198 -------------------DNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLE 238
DNK++S+P ++ L SL L L NN ++ LP + NL HL+
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLK 337
Query: 239 ELSLRGNPL 247
L+L GNPL
Sbjct: 338 FLALEGNPL 346
Score = 90.5 bits (223), Expect = 2e-18
Identities = 83/292 (28%), Positives = 129/292 (44%), Gaps = 33/292 (11%)
Query: 26 ETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGP 85
E L ER + L +L++ +N+L SL L P L +LD+ N LT+L
Sbjct: 64 EEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRL-LPALTVLDIHDNQLTSLPS 122
Query: 86 ELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRAL 145
+ L L+ L +N+L LP+ + R+L+ L L N + +L L
Sbjct: 123 AIRELENLQKLNVSHNKL---KILPEEITN---LRNLKCLYLQHNELTCISEGFEQLSNL 176
Query: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIP 205
+ L L N L ++PA +L SL L L N +K +P E+ + L +L N +++IP
Sbjct: 177 EDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIP 236
Query: 206 PQLSQLHSLRSLSLHNNLLTYLPR-----------------EILNLIHLEELSLRGNPLV 248
P+L+ + SL L L N L +LP E+L HL+ L N ++
Sbjct: 237 PELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHL----NSIL 292
Query: 249 VRFVRD--LTYDPPTLL---ELAARTIKIRNISYTPYDLPGNLLRYLGSASN 295
V +RD L P ++ L + +IS PY L L++L N
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGN 344
Score = 70.5 bits (171), Expect = 2e-12
Identities = 52/181 (28%), Positives = 89/181 (49%), Gaps = 3/181 (1%)
Query: 70 LQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSG 129
L++LD S T + E+ + + N +PK + + L + ++LS
Sbjct: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVE--LKEMVSDVDLSF 458
Query: 130 NCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
N + L L+ L L L N L S+P E+E+L L+ + L N K +P L +
Sbjct: 459 NKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIF 518
Query: 190 SLNYLVLCDNKIQSIPPQ-LSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
+L +++ +N++ S+ PQ + + +L +L L NN L +P E+ N ++L L L GNP
Sbjct: 519 TLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFR 578
Query: 249 V 249
V
Sbjct: 579 V 579
Score = 28.9 bits (63), Expect = 7.8
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 2/68 (2%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
+L+ +N++ S+ +L LD+ N L + PEL LRTLL N P A
Sbjct: 523 ILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRA 582
Query: 109 --LPKGLA 114
L KG A
Sbjct: 583 AILMKGTA 590
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 100 bits (249), Expect = 2e-21
Identities = 62/182 (34%), Positives = 103/182 (56%), Gaps = 9/182 (4%)
Query: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
+L+ LD+S N L ++ AL+ L L +N++G LP L L++L L+
Sbjct: 304 NLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIG---QLPSELGS---LSKLKILGLT 357
Query: 129 GNCFQEVPASLLELRALQTLSLGGNQ---LQSIPAEIENLQSLECLYLGGNFIKEIPPEL 185
GN F P +L L +L+ L +G +Q L +P I LQSL+ LY+ N ++ +P L
Sbjct: 358 GNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSL 417
Query: 186 GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
G++P+L L N ++ +P + Q +L+ L L +NLLT+LP + +L++L+ L+L N
Sbjct: 418 GSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDN 477
Query: 246 PL 247
P+
Sbjct: 478 PM 479
Score = 89.7 bits (221), Expect = 4e-18
Identities = 64/200 (32%), Positives = 96/200 (48%), Gaps = 7/200 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L + L N+ P+ L + L+++D+ N + A+ E+ L GL+ +N L
Sbjct: 167 LREIYLKRNQFEVFPQELCVLYT-LEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNL-- 223
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
LP L Q C L VL+LS N +P S ELR + + L GN+L+ +P I
Sbjct: 224 -PVLPASLCQ---CSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRW 279
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
SL LYLG + + L +L +L L N + P Q+ L +L L L +N +
Sbjct: 280 TSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIG 339
Query: 226 YLPREILNLIHLEELSLRGN 245
LP E+ +L L+ L L GN
Sbjct: 340 QLPSELGSLSKLKILGLTGN 359
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/201 (31%), Positives = 96/201 (47%), Gaps = 9/201 (4%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLA-LRGLRTL-LAKNNRLGGP 106
L L N L SL ALG L+ LD+S N + + +++ L LR L L + + P
Sbjct: 76 LYLDKNNLRSLCPALGL-LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIP 134
Query: 107 SALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQ 166
+ K L L++L L+GN + +P ++ L+ + L NQ + P E+ L
Sbjct: 135 VVIFKNL------HHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLY 188
Query: 167 SLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTY 226
+LE + L N I IP E+G+L L + N + +P L Q L L L +NLL
Sbjct: 189 TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248
Query: 227 LPREILNLIHLEELSLRGNPL 247
+P+ L + E+ L GN L
Sbjct: 249 IPKSFAELRKMTEIGLSGNRL 269
Score = 70.5 bits (171), Expect = 2e-12
Identities = 55/203 (27%), Positives = 87/203 (42%), Gaps = 6/203 (2%)
Query: 45 ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG 104
AL L L L +P + HL+LL ++GN L L E++ LR + K N+
Sbjct: 119 ALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF- 177
Query: 105 GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIEN 164
P+ L + +L++++L N +P + L LQ + N L +PA +
Sbjct: 178 --EVFPQELC---VLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQ 232
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
L L L N + IP L + + L N+++ +P + + SL L L N L
Sbjct: 233 CSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGL 292
Query: 225 TYLPREILNLIHLEELSLRGNPL 247
L L++L L L N L
Sbjct: 293 HRLRGSFRCLVNLRFLDLSQNHL 315
Score = 67.0 bits (162), Expect = 3e-11
Identities = 46/125 (36%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 125 LNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPE 184
++ S +P + L+ + L NQ++ IP EI+ L+++ LYL N ++ + P
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 185 LGNLPSLNYLVLCDNKI-QSIPPQLSQLHSLRSLSLHNNLLTYLPREIL-NLIHLEELSL 242
LG L SL L L N I S +S LH+LR L L+ L +P I NL HLE L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 243 RGNPL 247
GN L
Sbjct: 150 TGNHL 154
Score = 66.6 bits (161), Expect = 3e-11
Identities = 57/185 (30%), Positives = 88/185 (47%), Gaps = 8/185 (4%)
Query: 67 FPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLN 126
F L+ + + N + + E+ L+ +R L N L +L L L SL+ L+
Sbjct: 47 FTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNL---RSLCPALG---LLSSLESLD 100
Query: 127 LSGN-CFQEVPASLLELRALQTLSLGGNQLQSIPAEI-ENLQSLECLYLGGNFIKEIPPE 184
LS N F + L AL+ L L L+ IP I +NL LE L L GN +K +P E
Sbjct: 101 LSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKE 160
Query: 185 LGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRG 244
+ N L + L N+ + P +L L++L + L N + +P EI +L L++ +
Sbjct: 161 IVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMAS 220
Query: 245 NPLVV 249
N L V
Sbjct: 221 NNLPV 225
Score = 36.6 bits (83), Expect = 0.037
Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
++L L + +N L LP +LGS P+L++LD N L L + + L+ L ++N L
Sbjct: 398 QSLKELYIENNHLEYLPVSLGS-MPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLL 456
Query: 104 GGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVP 136
+ LP+ L +L+VL L N +E P
Sbjct: 457 ---THLPENLDS---LVNLKVLTLMDNPMEEPP 483
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/145 (42%), Positives = 84/145 (57%), Gaps = 8/145 (5%)
Query: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
R L L LS NC E+P +L L AL L++ N+LQ++P + L +L+ L L N +
Sbjct: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
Query: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
+PPE+G L SL L L N++QS+P L+ L SLR L LH+NLL +P ++ L L
Sbjct: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
Query: 240 LSLRGNPLVVRFVRDLTYDPPTLLE 264
L LR N L RDL PP LL+
Sbjct: 122 LDLRDNQL-----RDL---PPELLD 138
Score = 78.2 bits (191), Expect = 1e-14
Identities = 59/141 (41%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
LLL HN L LP ALG+ P L L V+ N L L P L AL L+ L N L
Sbjct: 7 LLLSHNCLSELPEALGA-LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPP 65
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
GL SL LNL+ N Q +PASL LR+L+ L L N L S+PA++ L L
Sbjct: 66 EIGGLG------SLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 119
Query: 169 ECLYLGGNFIKEIPPELGNLP 189
L L N ++++PPEL + P
Sbjct: 120 TRLDLRDNQLRDLPPELLDAP 140
Score = 63.5 bits (153), Expect = 3e-10
Identities = 35/83 (42%), Positives = 49/83 (59%)
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
++ L L L N + E+P LG LP+L +L + N++Q++PP L L +L+ L L NLL
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 225 TYLPREILNLIHLEELSLRGNPL 247
LP EI L L EL+L N L
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRL 83
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 95.5 bits (236), Expect = 7e-20
Identities = 77/229 (33%), Positives = 113/229 (49%), Gaps = 25/229 (10%)
Query: 41 GAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLA-LRGLRTLLAK 99
G +L RL L +NRL ++PR+L L+ L++ N ++ L LL+ L L +L
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAK-CSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
Query: 100 NN-----RLGGPSA----------------LPKGLAQSPLCRSLQVLNLSGNCFQEVPAS 138
N +GGPS +P G+ + L LN+ N +P
Sbjct: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSR--AKVLSKLNMKDNQLTSLPLD 397
Query: 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCD 198
++ L+L NQL IP ++ L SLE L L N +K++P LGNL L L L +
Sbjct: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
Query: 199 NKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
NK++S+P +++ L L+ L L NN LT LPR I +L +L L L N L
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLL 506
Score = 92.8 bits (229), Expect = 4e-19
Identities = 67/201 (33%), Positives = 108/201 (53%), Gaps = 8/201 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L L N L SLP +L + L++LD+ N L + + L L TL + NR+
Sbjct: 148 LMTLALSENSLTSLPDSLDN-LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITT 206
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
K L++ L +L++ N +++PA + EL L TL + NQL+ +P EI N
Sbjct: 207 VEKDIKNLSK------LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNC 260
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+ L L N + ++P +GNL SL+ L L N++ +IP L++ +L L+L NN ++
Sbjct: 261 TQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Query: 226 YLPREIL-NLIHLEELSLRGN 245
LP +L +L+ L L+L N
Sbjct: 321 TLPESLLSSLVKLNSLTLARN 341
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/190 (33%), Positives = 101/190 (53%), Gaps = 8/190 (4%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
+ L +L + N+L SLP G+ ++L +++ N LT + ++ L L L+ NN L
Sbjct: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVEL-NLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
Query: 104 GGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIE 163
LP GL R L+ L+L N + +P + L+ LQ L L NQL ++P I
Sbjct: 438 ---KKLPHGLGN---LRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIG 491
Query: 164 NLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDN-KIQSIPPQLSQLHSLRSLSLHNN 222
+L +L L LG N + +P E+G L +L L L DN + S+P +L+ L +S+ N
Sbjct: 492 HLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENC 551
Query: 223 LLTYLPREIL 232
L++LP +I+
Sbjct: 552 PLSHLPPQIV 561
Score = 83.6 bits (205), Expect = 3e-16
Identities = 65/210 (30%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 73 LDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCF 132
LD+S ++ L + L L L +N+L +LP A+ +L L LS N
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKL---QSLP---AEVGCLVNLMTLALSENSL 158
Query: 133 QEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLN 192
+P SL L+ L+ L L N+L+ IP+ + L SL LYL N I + ++ NL L+
Sbjct: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
Query: 193 YLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFV 252
L + +NKI+ +P ++ +L +L +L + +N L +LP+EI N + L L+ N L+
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELL---- 274
Query: 253 RDLTYDPPTLLELAARTIKIRNISYTPYDL 282
DL L L+ ++ +S P L
Sbjct: 275 -DLPDTIGNLSSLSRLGLRYNRLSAIPRSL 303
>gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
Length = 583
Score = 95.1 bits (235), Expect = 9e-20
Identities = 87/237 (36%), Positives = 122/237 (51%), Gaps = 31/237 (13%)
Query: 31 ELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPH-------LQLLDVSG-NALTA 82
ELE ERR RE LLL L RA G P L L+VSG +L A
Sbjct: 12 ELELAERERR--RE----LLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRA 65
Query: 83 LGPELL-ALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVP----- 136
GP L L L +L+ + N LG P P+ L P +L+VL+LSGN + +P
Sbjct: 66 PGPGLAQGLPQLHSLVLRRNALG-PGLSPE-LGPLP---ALRVLDLSGNALEALPPGQGL 120
Query: 137 --ASLLELRALQTLSLGGNQLQSIPAEIENLQS-LECLYLGGNFIKEIPPEL---GNLPS 190
A L LQ+L+L GN+L+ +PA++ L+ L L GN + P EL G LP
Sbjct: 121 GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL 180
Query: 191 LNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
L+ L DN ++ + P ++ L SL++L L NN L+ +P E+ + L+E++ RGN L
Sbjct: 181 LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
Score = 72.0 bits (175), Expect = 8e-13
Identities = 62/164 (37%), Positives = 79/164 (48%), Gaps = 22/164 (13%)
Query: 56 LVSLPRALGSGF-------PHLQLLDVSGNALTALGP-------ELLALRGLRTLLAKNN 101
LV ALG G P L++LD+SGNAL AL P E L L++L N
Sbjct: 80 LVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGN 139
Query: 102 RLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLS---LGGNQLQSI 158
RL LP LA+ LQ LNL+GNC PA L AL LS N L+ +
Sbjct: 140 RL---RELPADLARC--APRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLREL 194
Query: 159 PAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQ 202
+I +L SL+ L L N + EIP EL + P L + NK++
Sbjct: 195 SPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 93.6 bits (231), Expect = 3e-19
Identities = 74/240 (30%), Positives = 118/240 (49%), Gaps = 10/240 (4%)
Query: 14 AELNWSRLSVSTETLESELEARGEERRGAREALLR----LLLPHNRLVSLPRALGSGFPH 69
+E N +L + + LEA+G + ++ L L N++ + A
Sbjct: 130 SEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLG 189
Query: 70 LQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSG 129
L++L + N L++L E+ L LR L +N + S +PK ++Q R L N
Sbjct: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHI---SHIPKEISQLGNIRQLFFYN--- 243
Query: 130 NCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
N + P+ L L L+ LSLG N+L+ IP + +L++L L L N + P L LP
Sbjct: 244 NYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Query: 190 SLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVV 249
L L L N I S+P ++ +L +L +L + +N LT+L EI L+ ++EL L N L V
Sbjct: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363
Score = 92.4 bits (228), Expect = 6e-19
Identities = 65/203 (32%), Positives = 103/203 (50%), Gaps = 14/203 (6%)
Query: 51 LPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALP 110
L N++ +P ++ S L +L + N EL L L+ L N+L S
Sbjct: 540 LGKNQIKKIPASI-SNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKIS--- 595
Query: 111 KGLAQSPLC--RSLQVLNLSGNCFQEVPASLLELRALQTLSLG---GNQLQSIPAEIENL 165
S +C + +Q LN S N F P L +L++L+ L++ G +L +P E+ N+
Sbjct: 596 -----SDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNM 650
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
L+ L + N I+EIP +G L +L L +N+I +PP L L+ L+ L+L N LT
Sbjct: 651 TQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLT 710
Query: 226 YLPREILNLIHLEELSLRGNPLV 248
LP I N+ L+E++ NPL+
Sbjct: 711 ALPSAIYNIFSLKEINFDDNPLL 733
Score = 81.6 bits (200), Expect = 1e-15
Identities = 70/216 (32%), Positives = 101/216 (46%), Gaps = 18/216 (8%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNR------ 102
L L N L SLP + +L++L+VS N ++ + E+ L +R L NN
Sbjct: 193 LSLQENGLSSLPSEIQL-LHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS 251
Query: 103 ----LGGPSALPKGLAQS-------PLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLG 151
LG L G + P ++L+VLNL N P +L L L +L L
Sbjct: 252 DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLT 311
Query: 152 GNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQL 211
GN + S+P EI L++LE L + N + + E+ L + L L DNK++ I ++
Sbjct: 312 GNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENF 371
Query: 212 HSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
LR L L NLL +P +I LE LSL N L
Sbjct: 372 RELRILILDKNLLKNIPEKISCCAMLECLSLSDNKL 407
Score = 80.5 bits (197), Expect = 2e-15
Identities = 58/180 (32%), Positives = 95/180 (52%), Gaps = 6/180 (3%)
Query: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
+L++L + N L + L +L+ LR L + N+L + PK L P L L+L+
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQL---TTFPKALCFLP---KLISLDLT 311
Query: 129 GNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNL 188
GN +P + EL+ L+TL + N+L + EI L ++ L L N ++ I ++ N
Sbjct: 312 GNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENF 371
Query: 189 PSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
L L+L N +++IP ++S L LSL +N LT LP+ I L +L +L + N +V
Sbjct: 372 RELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMV 431
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/237 (28%), Positives = 116/237 (48%), Gaps = 9/237 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L +L + N +V + + S ++ L+ SGN +T + E+ + + + N++
Sbjct: 420 LRKLHVNRNNMVKITDCI-SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKI-- 476
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
P GL SL L+++GN E+P + + L L L N+L +L
Sbjct: 477 -MYFPLGLCALD---SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSL 532
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+L+ L LG N IK+IP + N+ SL+ L+LC NK ++ P +L L +L+ L L N L
Sbjct: 533 INLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592
Query: 226 YLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDL 282
+ +I NL +++L+ N + F +L +L +L IK R ++ P +L
Sbjct: 593 KISSDICNLKGIQKLNFSSNQF-IHFPIELC-QLQSLEQLNISQIKGRKLTRLPGEL 647
Score = 77.0 bits (188), Expect = 2e-14
Identities = 62/237 (26%), Positives = 107/237 (45%), Gaps = 36/237 (15%)
Query: 47 LRLL-LPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
LR+L L +N+L + P+AL P L LD++GN +++L E+ L+ L TLL +N+L
Sbjct: 282 LRVLNLEYNQLTTFPKAL-CFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKL-- 338
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
+ + +L ++ L L N+L+ I +IEN
Sbjct: 339 ---------------------------TFLAVEIFQLLKIKELQLADNKLEVISHKIENF 371
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+ L L L N +K IP ++ L L L DNK+ +P + +L++LR L ++ N +
Sbjct: 372 RELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMV 431
Query: 226 YLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDL 282
+ I +L ++ L GN + D+ + ++ + I Y P L
Sbjct: 432 KITDCISHLNNICSLEFSGN-----IITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483
Score = 75.1 bits (183), Expect = 9e-14
Identities = 51/183 (27%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L+L N+ + PR L + +LQ+LD+S N L + ++ L+G++ L +N+
Sbjct: 561 LILCCNKFETFPRELCT-LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF---IH 616
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
P L Q L + + G +P L + L+ L + N ++ IP I L++L
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
Query: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLP 228
L+ N I +PP L +L L L L N + ++P + + SL+ ++ +N L P
Sbjct: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
Query: 229 REI 231
EI
Sbjct: 737 VEI 739
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 93.6 bits (231), Expect = 3e-19
Identities = 65/194 (33%), Positives = 103/194 (53%), Gaps = 7/194 (3%)
Query: 48 RLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPS 107
+L L HN+L LP +G + +L++ GN L +L E+ L+ L+ L N L +
Sbjct: 75 KLNLSHNQLRVLPPEVGK-LTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL---T 130
Query: 108 ALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQS 167
+P A+ LCR L+VL+LS NC ++PA +L L+ L+L N IP + +L+
Sbjct: 131 EVP---AELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKE 187
Query: 168 LECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYL 227
L L++G N ++ I + +L SL + N I S P L + SL L+L+NN + L
Sbjct: 188 LIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTL 247
Query: 228 PREILNLIHLEELS 241
P E+ L L ++
Sbjct: 248 PSELHLLCRLVRIA 261
Score = 82.4 bits (202), Expect = 6e-16
Identities = 69/226 (30%), Positives = 105/226 (46%), Gaps = 23/226 (10%)
Query: 66 GFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVL 125
G +Q L++S N L L PE+ L + L NRL +LP+ ++ L + L+VL
Sbjct: 69 GLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRL---KSLPREVS---LLQCLKVL 122
Query: 126 NLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPEL 185
++ NC EVPA L R L+ LSL N L +PA +L L L L NF IP +
Sbjct: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182
Query: 186 GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
+L L +L + N++++I + L SL+ N + PR + + LE L+L N
Sbjct: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242
Query: 246 PLVVRFVRDLTYDPPTLLELAARTIKIR--------NISYTPYDLP 283
+ P+ L L R ++I +IS+ P P
Sbjct: 243 DIQTL---------PSELHLLCRLVRIAWNPMDKGLHISHNPLSKP 279
Score = 75.1 bits (183), Expect = 9e-14
Identities = 52/165 (31%), Positives = 83/165 (50%), Gaps = 4/165 (2%)
Query: 87 LLALRGLRTLLAKNNRLGGPSALPKGLAQSPL----CRSLQVLNLSGNCFQEVPASLLEL 142
LL+ R R+LL + S + +G+ P +Q LNLS N + +P + +L
Sbjct: 34 LLSGRDPRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKL 93
Query: 143 RALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQ 202
+ L+L GN+L+S+P E+ LQ L+ L++ N + E+P EL L L L N +
Sbjct: 94 TRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLS 153
Query: 203 SIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
+P + L LR L+L NN ++P + +L L L + N L
Sbjct: 154 QLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRL 198
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 92.4 bits (228), Expect = 6e-19
Identities = 64/195 (32%), Positives = 99/195 (50%), Gaps = 13/195 (6%)
Query: 71 QLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGN 130
Q L++SG L L + AL L+ L G LP+ + + R L++L L N
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGT---GLRELPEEIEE---LRELRILALDFN 77
Query: 131 CFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPS 190
+ +P L L L L LGGN+L ++PA+ LQSL CL++ GNF++ P L L +
Sbjct: 78 KLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVA 137
Query: 191 LNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL--- 247
L L + DN+++++P +L ++ LR L L+ N P +L + L L L N L
Sbjct: 138 LQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGF 197
Query: 248 ----VVRFVRDLTYD 258
+R +R +YD
Sbjct: 198 PDLHPLRALRVFSYD 212
Score = 82.8 bits (203), Expect = 5e-16
Identities = 51/142 (35%), Positives = 74/142 (52%), Gaps = 1/142 (0%)
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
P LP A+ L Q L LSG + +P+++ L LQ L + G L+ +P EIE L
Sbjct: 8 PDELPSD-AEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEEL 66
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+ L L L N ++ +P L LP L L L N++ ++P +QL SLR L + N L
Sbjct: 67 RELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLR 126
Query: 226 YLPREILNLIHLEELSLRGNPL 247
PR +L L+ L+ L + N L
Sbjct: 127 RFPRPLLRLVALQSLQMGDNRL 148
>gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isoform 1
[Homo sapiens]
Length = 414
Score = 91.7 bits (226), Expect = 1e-18
Identities = 82/238 (34%), Positives = 117/238 (49%), Gaps = 26/238 (10%)
Query: 118 LC-RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEI--ENLQ-SLECLYL 173
LC +SL+ L+LS N +++PA++ +L LQ L+L N L+S + LQ SL L L
Sbjct: 174 LCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDL 233
Query: 174 GGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILN 233
N IK +P + L L L L DN++ P ++ QL +LR LS N L +LP E N
Sbjct: 234 SKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRN 293
Query: 234 LIHLEELSLRGN----PLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRY 289
L LE L L GN P V+ ++ P TLLE +ARTI I Y + +P +L +
Sbjct: 294 L-SLEYLDLFGNTFEQPKVLPVIK--LQAPLTLLESSARTILHNRIPYGSHIIPFHLCQD 350
Query: 290 LGSASNCPNPKCGGVYFDCCVR------------QIKFVDFCGKYRLPLMHYLCSPEC 335
L +A C CG + ++ + VD G P++ Y CS C
Sbjct: 351 LDTAKIC---VCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGC 405
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 91.3 bits (225), Expect = 1e-18
Identities = 67/211 (31%), Positives = 108/211 (51%), Gaps = 11/211 (5%)
Query: 65 SGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCR--SL 122
SG + +++ ++G +T + L L GL+TL+ +NN + P P+ LC L
Sbjct: 11 SGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLI--PKVCPE------LCNLTQL 62
Query: 123 QVLNLSGNCFQEVPASLLELRALQTLSLGGNQL-QSIPAEIENLQSLECLYLGGNFIKEI 181
LNL N +EVP + L +L+ L L GN++ + P + LQ+L L L N + ++
Sbjct: 63 TTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQL 122
Query: 182 PPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELS 241
P E+ L SL Y+ + N++ SIP +L L +L L L+ N L +P EI L L++L
Sbjct: 123 PQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLL 182
Query: 242 LRGNPLVVRFVRDLTYDPPTLLELAARTIKI 272
L N + V +L++A I+I
Sbjct: 183 LARNNIGVLPEELCDLKKLRILDIAGNIIQI 213
Score = 82.4 bits (202), Expect = 6e-16
Identities = 86/318 (27%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
+ L ++ +P ALG P L+ L + N + + PEL L L TL NN L
Sbjct: 19 ITLNGKKMTKMPSALGK-LPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
Query: 109 LPKGLAQ--------SPLCR----------SLQVLNLSGNCFQEVPASLLELRALQTLSL 150
K L + +CR +L +LNL+ N ++P + L++L +S+
Sbjct: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
Query: 151 GGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQ 210
NQL SIP E+ L++L L L N + IP E+ L L L+L N I +P +L
Sbjct: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD 197
Query: 211 LHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVR--FVRDLTYDPPTLLELAAR 268
L LR L + N++ P +L L E GNPL ++ + + +L E+ +R
Sbjct: 198 LKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVISTQQENVWSLQEITSR 256
Query: 269 TIKIRNISYTPYDLPGNLLRYLGSASNCPNPK----CGGVYFDCCVRQIKFVDFCGKYRL 324
+ + P+ L ++ RY S K CG + + ++FV +++
Sbjct: 257 FVMNQLAENNPF-LMDDIERYPQVRSMISQGKTCAICGQYFITVWLECVRFVPPPKDWKI 315
Query: 325 -------PLMHYLCSPEC 335
PL +CS +C
Sbjct: 316 SKNLKLVPLQVLICSYKC 333
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 89.7 bits (221), Expect = 4e-18
Identities = 81/244 (33%), Positives = 111/244 (45%), Gaps = 24/244 (9%)
Query: 24 STETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTAL 83
S + L+A EE +L LLL N+L LP+ +L+ L +S N + L
Sbjct: 16 SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFR-LLNLRKLGLSDNEIQRL 74
Query: 84 GPELLALRGLRTLLAKNNRL-------------------GGP-SALPKGLAQSPLCRSLQ 123
PE+ L L N + G P S LP G Q RSL
Sbjct: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ---LRSLA 131
Query: 124 VLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPP 183
L L+ Q +P + L L TL L N L+S+PA + L LE L LGGN ++ +P
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 184 ELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLR 243
LG LP+L L L N++ ++PP+L L L L + N L LP E+ L+ L +L L
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 244 GNPL 247
N L
Sbjct: 252 QNLL 255
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/202 (33%), Positives = 98/202 (48%), Gaps = 7/202 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L + N + +P ++ L++ D SGN L+ L LR L L + L
Sbjct: 84 LVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL-- 140
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
ALP + +L L L N + +PASL L L+ L LGGN L+ +P + L
Sbjct: 141 -QALPGDVGN---LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+L L+L N + +PPELGNL L L + +N+++ +P +L L L L L NLL
Sbjct: 197 PNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLR 256
Query: 226 YLPREILNLIHLEELSLRGNPL 247
LP I L L L + N L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRL 278
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/180 (35%), Positives = 93/180 (51%), Gaps = 9/180 (5%)
Query: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
HL L DVS L AL ++ L L TL + N L +LP L+ L+ L+L
Sbjct: 132 HLALNDVS---LQALPGDVGNLANLVTLELRENLL---KSLPASLS---FLVKLEQLDLG 182
Query: 129 GNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNL 188
GN + +P +L L L+ L L NQL ++P E+ NL+ L CL + N ++E+P ELG L
Sbjct: 183 GNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 189 PSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
L L+L N ++ +P + QL L L + N L + I + +L EL L N L+
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Score = 76.3 bits (186), Expect = 4e-14
Identities = 72/223 (32%), Positives = 104/223 (46%), Gaps = 17/223 (7%)
Query: 69 HLQLLDVSGNALTALGPELLAL-RGLRTLLAKNNRLGGPSALPKGLAQSPLCR--SLQVL 125
H++ +D +L A+ E+ R L LL N+L LPK P R +L+ L
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQL---RELPK-----PFFRLLNLRKL 64
Query: 126 NLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPEL 185
LS N Q +P + L L + N + IP I+ ++LE GN + +P
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
Query: 186 GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
L SL +L L D +Q++P + L +L +L L NLL LP + L+ LE+L L GN
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
Query: 246 PLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLR 288
L V + D P L EL + +S P +L GNL R
Sbjct: 185 DLEV--LPDTLGALPNLREL---WLDRNQLSALPPEL-GNLRR 221
Score = 73.2 bits (178), Expect = 4e-13
Identities = 84/280 (30%), Positives = 114/280 (40%), Gaps = 64/280 (22%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L L N L SLP +L S L+ LD+ GN L L L AL LR L N+L
Sbjct: 153 LVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL-- 209
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
SALP L GN LR L L + N+L+ +PAE+ L
Sbjct: 210 -SALPPEL---------------GN-----------LRRLVCLDVSENRLEELPAELGGL 242
Query: 166 QSLECLYLGGNFIKEIPPELGNL-----------------------PSLNYLVLCDNKIQ 202
L L L N ++ +P +G L +L+ L+L +N +
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 203 SIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTL 262
++P L +L L +L++ N L LP EI + L LSLR N L V PP L
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL--------PPEL 354
Query: 263 ---LELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNP 299
EL + + P+ L L+ L A N P
Sbjct: 355 AHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQP 394
Score = 54.7 bits (130), Expect = 1e-07
Identities = 46/119 (38%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 38 ERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLL 97
E G E L L+L N L++LPR+LG L L+V N L AL PE+ L L
Sbjct: 283 EAIGDCENLSELILTENLLMALPRSLGK-LTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 98 AKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQ 156
++NRL + LP LA + L VL+++GN Q +P +L L L+ L L NQ Q
Sbjct: 342 LRDNRL---AVLPPELAHT---TELHVLDVAGNRLQSLPFALTHLN-LKALWLAENQAQ 393
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 89.7 bits (221), Expect = 4e-18
Identities = 81/244 (33%), Positives = 111/244 (45%), Gaps = 24/244 (9%)
Query: 24 STETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTAL 83
S + L+A EE +L LLL N+L LP+ +L+ L +S N + L
Sbjct: 16 SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFR-LLNLRKLGLSDNEIQRL 74
Query: 84 GPELLALRGLRTLLAKNNRL-------------------GGP-SALPKGLAQSPLCRSLQ 123
PE+ L L N + G P S LP G Q RSL
Sbjct: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ---LRSLA 131
Query: 124 VLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPP 183
L L+ Q +P + L L TL L N L+S+PA + L LE L LGGN ++ +P
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 184 ELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLR 243
LG LP+L L L N++ ++PP+L L L L + N L LP E+ L+ L +L L
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 244 GNPL 247
N L
Sbjct: 252 QNLL 255
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/202 (33%), Positives = 98/202 (48%), Gaps = 7/202 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L + N + +P ++ L++ D SGN L+ L LR L L + L
Sbjct: 84 LVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL-- 140
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
ALP + +L L L N + +PASL L L+ L LGGN L+ +P + L
Sbjct: 141 -QALPGDVGN---LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+L L+L N + +PPELGNL L L + +N+++ +P +L L L L L NLL
Sbjct: 197 PNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLR 256
Query: 226 YLPREILNLIHLEELSLRGNPL 247
LP I L L L + N L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRL 278
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/180 (35%), Positives = 93/180 (51%), Gaps = 9/180 (5%)
Query: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
HL L DVS L AL ++ L L TL + N L +LP L+ L+ L+L
Sbjct: 132 HLALNDVS---LQALPGDVGNLANLVTLELRENLL---KSLPASLS---FLVKLEQLDLG 182
Query: 129 GNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNL 188
GN + +P +L L L+ L L NQL ++P E+ NL+ L CL + N ++E+P ELG L
Sbjct: 183 GNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 189 PSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
L L+L N ++ +P + QL L L + N L + I + +L EL L N L+
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Score = 76.3 bits (186), Expect = 4e-14
Identities = 72/223 (32%), Positives = 104/223 (46%), Gaps = 17/223 (7%)
Query: 69 HLQLLDVSGNALTALGPELLAL-RGLRTLLAKNNRLGGPSALPKGLAQSPLCR--SLQVL 125
H++ +D +L A+ E+ R L LL N+L LPK P R +L+ L
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQL---RELPK-----PFFRLLNLRKL 64
Query: 126 NLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPEL 185
LS N Q +P + L L + N + IP I+ ++LE GN + +P
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
Query: 186 GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN 245
L SL +L L D +Q++P + L +L +L L NLL LP + L+ LE+L L GN
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
Query: 246 PLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLR 288
L V + D P L EL + +S P +L GNL R
Sbjct: 185 DLEV--LPDTLGALPNLREL---WLDRNQLSALPPEL-GNLRR 221
Score = 73.2 bits (178), Expect = 4e-13
Identities = 84/280 (30%), Positives = 114/280 (40%), Gaps = 64/280 (22%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L L N L SLP +L S L+ LD+ GN L L L AL LR L N+L
Sbjct: 153 LVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL-- 209
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
SALP L GN LR L L + N+L+ +PAE+ L
Sbjct: 210 -SALPPEL---------------GN-----------LRRLVCLDVSENRLEELPAELGGL 242
Query: 166 QSLECLYLGGNFIKEIPPELGNL-----------------------PSLNYLVLCDNKIQ 202
L L L N ++ +P +G L +L+ L+L +N +
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 203 SIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTL 262
++P L +L L +L++ N L LP EI + L LSLR N L V PP L
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL--------PPEL 354
Query: 263 ---LELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNP 299
EL + + P+ L L+ L A N P
Sbjct: 355 AHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQP 394
Score = 54.7 bits (130), Expect = 1e-07
Identities = 46/119 (38%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 38 ERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLL 97
E G E L L+L N L++LPR+LG L L+V N L AL PE+ L L
Sbjct: 283 EAIGDCENLSELILTENLLMALPRSLGK-LTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 98 AKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQ 156
++NRL + LP LA + L VL+++GN Q +P +L L L+ L L NQ Q
Sbjct: 342 LRDNRL---AVLPPELAHT---TELHVLDVAGNRLQSLPFALTHLN-LKALWLAENQAQ 393
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 88.6 bits (218), Expect = 8e-18
Identities = 69/198 (34%), Positives = 99/198 (50%), Gaps = 13/198 (6%)
Query: 54 NRLVSLPRALGSGFPHLQ---LLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALP 110
N L LP + FP LQ L V+ +L +L + L L +L + N L + LP
Sbjct: 115 NPLTRLPES----FPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL---TYLP 167
Query: 111 KGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLEC 170
L Q R L+ L+L N +P S+ L L+ L L GNQL +P EI NL++L C
Sbjct: 168 DSLTQ---LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLC 224
Query: 171 LYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPRE 230
L + N ++ +P E+ L SL LV+ N +++IP + +L L L + N LT LP
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 231 ILNLIHLEELSLRGNPLV 248
+ L EL L N L+
Sbjct: 285 VGECESLTELVLTENQLL 302
Score = 87.0 bits (214), Expect = 2e-17
Identities = 64/195 (32%), Positives = 93/195 (47%), Gaps = 6/195 (3%)
Query: 53 HNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKG 112
H LV +P + L+ L + N L L + L LR L +N + LP
Sbjct: 21 HCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI---QRLPPE 77
Query: 113 LAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLY 172
+A L L++S N E+P S+ +ALQ GN L +P LQ+L CL
Sbjct: 78 IANF---MQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLS 134
Query: 173 LGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREIL 232
+ ++ +P +GNL +L L L +N + +P L+QL L L L NN + LP I
Sbjct: 135 VNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIG 194
Query: 233 NLIHLEELSLRGNPL 247
L+HL++L L GN L
Sbjct: 195 ALLHLKDLWLDGNQL 209
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/203 (33%), Positives = 100/203 (49%), Gaps = 7/203 (3%)
Query: 45 ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG 104
+L LLL N+L LP L+ L +S N + L PE+ L L N +
Sbjct: 37 SLEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEI- 94
Query: 105 GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIEN 164
+P+ ++ C++LQV + SGN +P S EL+ L LS+ LQS+P I N
Sbjct: 95 --PEIPESIS---FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGN 149
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
L +L L L N + +P L L L L L +N+I ++P + L L+ L L N L
Sbjct: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209
Query: 225 TYLPREILNLIHLEELSLRGNPL 247
+ LP+EI NL +L L + N L
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRL 232
Score = 82.4 bits (202), Expect = 6e-16
Identities = 66/208 (31%), Positives = 99/208 (47%), Gaps = 8/208 (3%)
Query: 38 ERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLL 97
E GA L L L N+L LP+ +G+ +L LDVS N L L E+ L L L+
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGN-LKNLLCLDVSENRLERLPEEISGLTSLTDLV 249
Query: 98 AKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQS 157
N L +P G+ + + L +L + N ++P ++ E +L L L NQL +
Sbjct: 250 ISQNLL---ETIPDGIGK---LKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLT 303
Query: 158 IPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSL 217
+P I L+ L L N + +P E+G SL + DN++ IP ++SQ L L
Sbjct: 304 LPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVL 363
Query: 218 SLHNNLLTYLPREILNLIHLEELSLRGN 245
+ N L +LP L + L+ L L N
Sbjct: 364 DVAGNRLLHLPLS-LTALKLKALWLSDN 390
Score = 80.9 bits (198), Expect = 2e-15
Identities = 63/193 (32%), Positives = 93/193 (48%), Gaps = 7/193 (3%)
Query: 56 LVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQ 115
L SLP +G+ + +L L++ N LT L L LR L L NN + LP+ +
Sbjct: 140 LQSLPENIGNLY-NLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYN---LPESIGA 195
Query: 116 SPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGG 175
L+ L L GN E+P + L+ L L + N+L+ +P EI L SL L +
Sbjct: 196 ---LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
Query: 176 NFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLI 235
N ++ IP +G L L+ L + N++ +P + + SL L L N L LP+ I L
Sbjct: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLK 312
Query: 236 HLEELSLRGNPLV 248
L L+ N LV
Sbjct: 313 KLSNLNADRNKLV 325
Score = 79.3 bits (194), Expect = 5e-15
Identities = 61/203 (30%), Positives = 100/203 (49%), Gaps = 7/203 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L L L +N + +LP ++G+ HL+ L + GN L+ L E+ L+ L L NRL
Sbjct: 176 LEELDLGNNEIYNLPESIGA-LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL-- 232
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
LP+ ++ SL L +S N + +P + +L+ L L + N+L +P +
Sbjct: 233 -ERLPEEISG---LTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+SL L L N + +P +G L L+ L NK+ S+P ++ SL + +N LT
Sbjct: 289 ESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLT 348
Query: 226 YLPREILNLIHLEELSLRGNPLV 248
+P E+ L L + GN L+
Sbjct: 349 RIPAEVSQATELHVLDVAGNRLL 371
Score = 78.6 bits (192), Expect = 9e-15
Identities = 69/231 (29%), Positives = 111/231 (48%), Gaps = 12/231 (5%)
Query: 17 NWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVS 76
N + LSV+ +L+S E G L L L N L LP +L + L+ LD+
Sbjct: 129 NLTCLSVNDISLQSL-----PENIGNLYNLASLELRENLLTYLPDSL-TQLRRLEELDLG 182
Query: 77 GNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVP 136
N + L + AL L+ L N+L S LP+ + ++L L++S N + +P
Sbjct: 183 NNEIYNLPESIGALLHLKDLWLDGNQL---SELPQEIGN---LKNLLCLDVSENRLERLP 236
Query: 137 ASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVL 196
+ L +L L + N L++IP I L+ L L + N + ++P +G SL LVL
Sbjct: 237 EEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVL 296
Query: 197 CDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
+N++ ++P + +L L +L+ N L LP+EI L +R N L
Sbjct: 297 TENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRL 347
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 87.8 bits (216), Expect = 1e-17
Identities = 66/205 (32%), Positives = 107/205 (52%), Gaps = 17/205 (8%)
Query: 47 LRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGP 106
L+ L+ +R + P S +LDV+G L L + L+ +N+L
Sbjct: 5 LKKLVEESREKNQPEVDMSDRGISNMLDVNG---------LFTLSHITQLVLSHNKL--- 52
Query: 107 SALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQ 166
+ +P +A+ ++L+VLN N +E+P + L+ L+ L+LG N+L ++P +L
Sbjct: 53 TMVPPNIAE---LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLP 109
Query: 167 SLECLYLGGNFIKE--IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
+LE L L N + E +P L +L L L DN + +PP + +L L+ LSL +N L
Sbjct: 110 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 169
Query: 225 TYLPREILNLIHLEELSLRGNPLVV 249
LP+EI L L+EL ++GN L V
Sbjct: 170 ISLPKEIGELTQLKELHIQGNRLTV 194
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 8/168 (4%)
Query: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
H+ L +S N LT + P + L+ L L NN++ LP ++ + L+ LNL
Sbjct: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI---EELPTQISS---LQKLKHLNLG 94
Query: 129 GNCFQEVPASLLELRALQTLSLGGNQLQ--SIPAEIENLQSLECLYLGGNFIKEIPPELG 186
N +P L AL+ L L N L S+P L +L LYL N + +PP++G
Sbjct: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 154
Query: 187 NLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNL 234
L L L L DN + S+P ++ +L L+ L + N LT LP E+ NL
Sbjct: 155 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 62.4 bits (150), Expect = 6e-10
Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 28/145 (19%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
+ L L L NRL +LPR GS P L++LD++ N L+
Sbjct: 86 QKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYNNLS---------------------- 122
Query: 104 GGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIE 163
++LP +L+ L LS N F+ +P + +L LQ LSL N L S+P EI
Sbjct: 123 --ENSLPGNFF---YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 177
Query: 164 NLQSLECLYLGGNFIKEIPPELGNL 188
L L+ L++ GN + +PPELGNL
Sbjct: 178 ELTQLKELHIQGNRLTVLPPELGNL 202
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 87.8 bits (216), Expect = 1e-17
Identities = 66/202 (32%), Positives = 101/202 (50%), Gaps = 8/202 (3%)
Query: 47 LRLL-LPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
LR+L L N L +LP+++ L+ LD+ N L L ++ LR L NN L
Sbjct: 163 LRILELRENHLKTLPKSMHK-LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL-- 219
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
LP + + + L L++S N + V + AL+ L L N LQ +P I L
Sbjct: 220 -QVLPGSIGK---LKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLL 275
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
+ L L + N + +P +GNL L N+++S+P + LHSLR+L++ N L
Sbjct: 276 KKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLP 335
Query: 226 YLPREILNLIHLEELSLRGNPL 247
LPREI + ++ +SLR N L
Sbjct: 336 ELPREIGSCKNVTVMSLRSNKL 357
Score = 83.6 bits (205), Expect = 3e-16
Identities = 59/200 (29%), Positives = 96/200 (48%), Gaps = 7/200 (3%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L L + +N L LP ++G L LD+S N + + ++ L LL +N L
Sbjct: 209 LRELWMDNNALQVLPGSIGK-LKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML-- 265
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
LP + L + L L + N +P ++ L L+ N+L+S+P+ I L
Sbjct: 266 -QQLPDSIG---LLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
SL L + NF+ E+P E+G+ ++ + L NK++ +P ++ Q+ LR L+L +N L
Sbjct: 322 HSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLK 381
Query: 226 YLPREILNLIHLEELSLRGN 245
LP L L L L N
Sbjct: 382 NLPFSFTKLKELAALWLSDN 401
Score = 79.0 bits (193), Expect = 7e-15
Identities = 61/226 (26%), Positives = 104/226 (46%), Gaps = 24/226 (10%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
+AL +L +P N L +LP + S +L+ LD+S N + + + L + A N +
Sbjct: 69 QALRKLSIPDNDLSNLPTTIAS-LVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 127
Query: 104 GGPSALPKGLAQSPLCRSL--------------------QVLNLSGNCFQEVPASLLELR 143
S LP G Q L ++L L N + +P S+ +L
Sbjct: 128 ---SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLA 184
Query: 144 ALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQS 203
L+ L LG N+ +P ++ +Q+L L++ N ++ +P +G L L YL + N+I++
Sbjct: 185 QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIET 244
Query: 204 IPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVV 249
+ +S +L L L +N+L LP I L L L + N L +
Sbjct: 245 VDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTM 290
Score = 61.2 bits (147), Expect = 1e-09
Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 8/187 (4%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
EAL LLL N L LP ++G L L V N LT L + L L N L
Sbjct: 253 EALEDLLLSSNMLQQLPDSIGL-LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNEL 311
Query: 104 GGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIE 163
+LP + SL+ L + N E+P + + + +SL N+L+ +P EI
Sbjct: 312 ---ESLPSTIGY---LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIG 365
Query: 164 NLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLH-SLRSLSLHNN 222
+Q L L L N +K +P L L L L DN+ +++ P ++ H + L N
Sbjct: 366 QMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNY 425
Query: 223 LLTYLPR 229
+ PR
Sbjct: 426 MFPQQPR 432
Score = 50.8 bits (120), Expect = 2e-06
Identities = 29/92 (31%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 141 ELRALQTLSLGGNQLQSIPAEIENLQ-SLECLYLGGNFIKEIPPELGNLPSLNYLVLCDN 199
E + L LQ +P E+ N + +LE LYL N I+E+P +L N +L L + DN
Sbjct: 20 EEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDN 79
Query: 200 KIQSIPPQLSQLHSLRSLSLHNNLLTYLPREI 231
+ ++P ++ L +L+ L + N + P I
Sbjct: 80 DLSNLPTTIASLVNLKELDISKNGVQEFPENI 111
Score = 45.4 bits (106), Expect = 8e-05
Identities = 25/69 (36%), Positives = 43/69 (62%), Gaps = 1/69 (1%)
Query: 178 IKEIPPELGNLP-SLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIH 236
++++P E+ N +L L L N+I+ +P QL +LR LS+ +N L+ LP I +L++
Sbjct: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
Query: 237 LEELSLRGN 245
L+EL + N
Sbjct: 94 LKELDISKN 102
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 85.1 bits (209), Expect = 9e-17
Identities = 64/203 (31%), Positives = 111/203 (54%), Gaps = 10/203 (4%)
Query: 56 LVSLPRALGSGFPHLQLLDVSGNALTALGPELLA-LRGLRTLLAKNNRLGGPSALPKGLA 114
L P L +L+ +D+S N + +L P L+ L++L NN+L + LP +
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKL---TVLPDEIC 82
Query: 115 QSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLG 174
+ L+ L+L+ N +E+P++ +L AL+TLSL GNQL ++P ++ +L+ L+ + L
Sbjct: 83 N---LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLS 139
Query: 175 GNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNL--LTYLPREIL 232
N I+ IP +G L + L L N+I I ++S L+ L L N L+ LP+ IL
Sbjct: 140 KNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
Query: 233 NLIHLEELSLRGNPLVVRFVRDL 255
+ + L++ GN ++ +R+L
Sbjct: 199 SDSQICLLAVEGNLFEIKKLREL 221
Score = 75.1 bits (183), Expect = 9e-14
Identities = 48/143 (33%), Positives = 78/143 (54%), Gaps = 7/143 (4%)
Query: 111 KGLAQSP-----LCRSLQVLNLSGNCFQEVPASLL-ELRALQTLSLGGNQLQSIPAEIEN 164
+GL + P L +L+ ++LS N + +P L+ + L++LSL N+L +P EI N
Sbjct: 24 RGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICN 83
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
L+ LE L L N ++E+P G L +L L L N++ ++PPQL L L + L N +
Sbjct: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
Query: 225 TYLPREILNLIHLEELSLRGNPL 247
+P + L + EL+L N +
Sbjct: 144 RSIPDSVGEL-QVIELNLNQNQI 165
Score = 43.1 bits (100), Expect = 4e-04
Identities = 49/171 (28%), Positives = 74/171 (43%), Gaps = 41/171 (23%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L +N L LP G L+ L +SGN L AL P+L +L
Sbjct: 90 LSLNNNHLRELPSTFGQ-LSALKTLSLSGNQLGALPPQLCSL------------------ 130
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
R L V++LS N + +P S+ EL+ ++ L+L NQ+ I +I L
Sbjct: 131 -----------RHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRL 178
Query: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKI--QSIPPQLSQLHSLRSL 217
+ L L N + EL LP +L D++I ++ L ++ LR L
Sbjct: 179 KILRLEENCL-----ELSMLPQ---SILSDSQICLLAVEGNLFEIKKLREL 221
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 84.3 bits (207), Expect = 2e-16
Identities = 65/232 (28%), Positives = 114/232 (49%), Gaps = 31/232 (13%)
Query: 20 RLSVSTETLESELEARGEERRGAREALLRL------LLPHNRLVSLPRALGSGFPHLQLL 73
R V+ E L+ EE + +LL+L L L+ +P +G F +L +L
Sbjct: 53 REKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGR-FQNLIVL 111
Query: 74 DVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQV--------- 124
D+S N ++ + P + L L+ L+ N++ +PK L+ L++
Sbjct: 112 DLSRNTISEIPPGIGLLTRLQELILSYNKI---KTVPKELSNCASLEKLELAVNRDICDL 168
Query: 125 ------------LNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLY 172
L+LS N F +P ++L + AL+ L +G N+L+ +P IE +Q+L L+
Sbjct: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
Query: 173 LGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
L N I +P + N+ +L LVL +NK+Q IP + ++ +LR ++ +N L
Sbjct: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 82.8 bits (203), Expect = 5e-16
Identities = 46/128 (35%), Positives = 73/128 (57%)
Query: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
+ L L L N +P S+ ++ L++L N+L+S+P + +LQ L CL + N I
Sbjct: 683 KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
Query: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
IP E+G L +L +L + NK+ +P QL + LR+L+L N +T LP ++ L L +
Sbjct: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
Query: 240 LSLRGNPL 247
L L+GN L
Sbjct: 803 LELKGNCL 810
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/164 (29%), Positives = 89/164 (54%), Gaps = 9/164 (5%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L HN++V++P ++ + +L+ L S N L +L + +L+ LR L N + S
Sbjct: 688 LKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI---SM 743
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
+P + L ++LQ L+++GN +P L + L+TL+LG N + S+P ++ L L
Sbjct: 744 IPIEIG---LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Query: 169 ECLYLGGNFIKEIPPELGNLPSL--NYLVLCDNKIQSIPPQLSQ 210
L L GN + +P +LG L + LV+ D+ ++P ++ +
Sbjct: 801 TQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKE 844
Score = 31.2 bits (69), Expect = 1.6
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 29/130 (22%)
Query: 145 LQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELG--NLPSLNYLVLCDNK-- 200
L+ L + + IPA + L++L LYL GN E +G +L L +L + K
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 201 -------IQSIPPQLSQ------------LHSLR------SLSLHNNLLTYLPREILNLI 235
I + P L++ L+SL+ L L N L +P I +L
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
Query: 236 HLEELSLRGN 245
+L+EL L+ N
Sbjct: 659 NLQELDLKSN 668
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 82.8 bits (203), Expect = 5e-16
Identities = 46/128 (35%), Positives = 73/128 (57%)
Query: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
+ L L L N +P S+ ++ L++L N+L+S+P + +LQ L CL + N I
Sbjct: 683 KRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
Query: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
IP E+G L +L +L + NK+ +P QL + LR+L+L N +T LP ++ L L +
Sbjct: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
Query: 240 LSLRGNPL 247
L L+GN L
Sbjct: 803 LELKGNCL 810
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/164 (29%), Positives = 89/164 (54%), Gaps = 9/164 (5%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L HN++V++P ++ + +L+ L S N L +L + +L+ LR L N + S
Sbjct: 688 LKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI---SM 743
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
+P + L ++LQ L+++GN +P L + L+TL+LG N + S+P ++ L L
Sbjct: 744 IPIEIG---LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Query: 169 ECLYLGGNFIKEIPPELGNLPSL--NYLVLCDNKIQSIPPQLSQ 210
L L GN + +P +LG L + LV+ D+ ++P ++ +
Sbjct: 801 TQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKE 844
Score = 31.2 bits (69), Expect = 1.6
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 29/130 (22%)
Query: 145 LQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELG--NLPSLNYLVLCDNK-- 200
L+ L + + IPA + L++L LYL GN E +G +L L +L + K
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 201 -------IQSIPPQLSQ------------LHSLR------SLSLHNNLLTYLPREILNLI 235
I + P L++ L+SL+ L L N L +P I +L
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
Query: 236 HLEELSLRGN 245
+L+EL L+ N
Sbjct: 659 NLQELDLKSN 668
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 82.8 bits (203), Expect = 5e-16
Identities = 61/177 (34%), Positives = 92/177 (51%), Gaps = 7/177 (3%)
Query: 86 ELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRAL 145
ELL GL+ L + ++LP+ LAQ +L L L N VP ++ L L
Sbjct: 33 ELLKDEGLQYLERLYMKRNSLTSLPENLAQK--LPNLVELYLHSNNIVVVPEAIGSLVKL 90
Query: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIP 205
Q L L N L+ + EI L++L L L N ++ +PPE+G+L L L + N++ ++P
Sbjct: 91 QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLP 150
Query: 206 PQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN-----PLVVRFVRDLTY 257
+L SL+ L++ N L Y+PR + L L ELS+ GN PL + R+L Y
Sbjct: 151 ERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQY 207
Score = 76.6 bits (187), Expect = 3e-14
Identities = 59/191 (30%), Positives = 91/191 (47%), Gaps = 31/191 (16%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L+ L L N +V +P A+GS LQ LD+S NAL + PE+ LR LR L NN+L
Sbjct: 67 LVELYLHSNNIVVVPEAIGS-LVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL-- 123
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
Q +P + +L+ LQTL + N+L ++P +
Sbjct: 124 ---------------------------QFLPPEVGDLKELQTLDISTNRLLTLPERLHMC 156
Query: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNL-L 224
SL+ L + N + +P L LPSLN L + N++ +P L + L+ + + NN+ L
Sbjct: 157 LSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHL 216
Query: 225 TYLPREILNLI 235
LP + N +
Sbjct: 217 KGLPSYLYNKV 227
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 82.4 bits (202), Expect = 6e-16
Identities = 76/226 (33%), Positives = 110/226 (48%), Gaps = 23/226 (10%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALT-ALGPELLALRGLRTLLAKNNR-- 102
LL L L NRL SLP + HLQ L ++GN L A +L A+ L+TL ++ +
Sbjct: 153 LLYLDLSENRLESLPPQMRR-LVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRT 211
Query: 103 -------LGGPSALP------KGLAQSPLCR----SLQVLNLSGNCFQEVPASLLELRAL 145
L G S L L + P C SL+ LNLS N E+ + + +
Sbjct: 212 QSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHV 271
Query: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK--EIPPELGNLPSLNYLVLCDNKIQS 203
+TL+L NQL S+P+ I L L+ LYL N + +P +G L +L + +N ++
Sbjct: 272 ETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLEL 331
Query: 204 IPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVV 249
+P L + LR L L+ N L LP I L +E L +R NP +V
Sbjct: 332 VPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLV 377
Score = 77.0 bits (188), Expect = 2e-14
Identities = 80/259 (30%), Positives = 115/259 (44%), Gaps = 38/259 (14%)
Query: 42 AREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNN 101
A +L L L L LP L + L+ L VS N LT L EL +L LR ++A+ N
Sbjct: 31 AMTSLRWLKLNRTGLCYLPEELAA-LQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARAN 89
Query: 102 RLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAE 161
L VP + +L L L L NQL P E
Sbjct: 90 SLKNSG---------------------------VPDDIFKLDDLSVLDLSHNQLTECPRE 122
Query: 162 IENLQSLECLYLGGNFIKEIPPELG-NLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLH 220
+EN +++ L L N I IP +L NL L YL L +N+++S+PPQ+ +L L++L L+
Sbjct: 123 LENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLN 182
Query: 221 NNLLTYLP-REILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTP 279
N L + R++ + L+ L LR R +L L LA + +++ P
Sbjct: 183 GNPLLHAQLRQLPAMTALQTLHLRSTQ---RTQSNLPTSLEGLSNLADVDLSCNDLTRVP 239
Query: 280 ---YDLPGNLLRYLGSASN 295
Y LP LR L +SN
Sbjct: 240 ECLYTLPS--LRRLNLSSN 256
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/204 (31%), Positives = 88/204 (43%), Gaps = 30/204 (14%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
+L L L HN + ++P L L LD+S N L +L P++ L L+TL+ N L
Sbjct: 129 MLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL-- 186
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGN--CFQEVPASLLELRALQTLSLGGNQLQSIPAEIE 163
L L Q P +LQ L+L +P SL L L + L N L +P
Sbjct: 187 ---LHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP---- 239
Query: 164 NLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNL 223
ECLY LPSL L L N+I + + Q + +L+L N
Sbjct: 240 -----ECLY--------------TLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 224 LTYLPREILNLIHLEELSLRGNPL 247
LT LP I L L++L L N L
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKL 304
Score = 57.4 bits (137), Expect = 2e-08
Identities = 41/127 (32%), Positives = 68/127 (53%), Gaps = 4/127 (3%)
Query: 125 LNLSGNCFQE--VPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIP 182
++LSGN F+ P ++ + +L+ L L L +P E+ LQ LE L + N + +
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
Query: 183 PELGNLPSLNYLVLCDNKIQS--IPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEEL 240
EL +LPSL +V N +++ +P + +L L L L +N LT PRE+ N ++ L
Sbjct: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
Query: 241 SLRGNPL 247
+L N +
Sbjct: 133 NLSHNSI 139
Score = 56.2 bits (134), Expect = 5e-08
Identities = 49/177 (27%), Positives = 81/177 (45%), Gaps = 17/177 (9%)
Query: 58 SLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSP 117
+LP +L G +L +D+S N LT + L L LR L +N++ +
Sbjct: 214 NLPTSL-EGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQI----------TELS 262
Query: 118 LCRS----LQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQ--SIPAEIENLQSLECL 171
LC ++ LNLS N +P+++ +L L+ L L N+L +P+ I L +LE
Sbjct: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 172 YLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLP 228
N ++ +P L P L LVL N + ++P + L + L + N +P
Sbjct: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 82.0 bits (201), Expect = 8e-16
Identities = 51/149 (34%), Positives = 79/149 (53%), Gaps = 23/149 (15%)
Query: 121 SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180
SL+ LNL NC + +P ++L L+AL L++ NQL ++P + NL L+ L N +
Sbjct: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVS 164
Query: 181 IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREIL-------- 232
+P E+G+L L L + N+IQ+IP Q+ L +LR L++ N L +LP E+
Sbjct: 165 LPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLD 224
Query: 233 --------------NLIHLEELSLRGNPL 247
NL HL+ ++L NPL
Sbjct: 225 FSCNKITTIPVCYRNLRHLQTITLDNNPL 253
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/181 (32%), Positives = 89/181 (49%), Gaps = 9/181 (4%)
Query: 51 LPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALP 110
L NRL +P F L+ L++ N + + +L L+ L L N+L S LP
Sbjct: 89 LSRNRLSEIPIE-ACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL---STLP 144
Query: 111 KGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLEC 170
L PL +VL S N +P + LR L L + N++Q+IP++I NL++L
Sbjct: 145 VHLCNLPL----KVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRD 200
Query: 171 LYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPRE 230
L + N + +P EL LP + C NKI +IP L L++++L NN L P +
Sbjct: 201 LNVRRNHLVHLPEELAELPLIRLDFSC-NKITTIPVCYRNLRHLQTITLDNNPLQSPPAQ 259
Query: 231 I 231
I
Sbjct: 260 I 260
Score = 71.2 bits (173), Expect = 1e-12
Identities = 47/139 (33%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
Query: 110 PKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLE 169
P+G A L + + +LS N E+P +L+ L+L N ++ IP I NLQ+L
Sbjct: 73 PRGAANHDLTDTTRA-DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALT 131
Query: 170 CLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPR 229
L + N + +P L NLP L L+ +NK+ S+P ++ L L L + N + +P
Sbjct: 132 FLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPS 190
Query: 230 EILNLIHLEELSLRGNPLV 248
+I NL L +L++R N LV
Sbjct: 191 QIGNLEALRDLNVRRNHLV 209
Score = 63.2 bits (152), Expect = 4e-10
Identities = 45/114 (39%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L+ +N+LVSLP +G HL LDVS N + + ++ L LR L + N L
Sbjct: 155 LIASNNKLVSLPEEIGH-LRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHL---VH 210
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEI 162
LP+ LA+ PL R L+ S N +P LR LQT++L N LQS PA+I
Sbjct: 211 LPEELAELPLIR----LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 45 ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG 104
+L L L N + +P A+ L L++S N L+ L L L L+ L+A NN+L
Sbjct: 106 SLENLNLYQNCIRYIPEAI-LNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKL- 162
Query: 105 GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIEN 164
+LP+ + R L L++S N Q +P+ + L AL+ L++ N L +P E+
Sbjct: 163 --VSLPEEIGH---LRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAE 217
Query: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQL---SQLHSLRSLSL 219
L + L N I IP NL L + L +N +QS P Q+ ++H + L++
Sbjct: 218 LPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
sapiens]
Length = 555
Score = 81.3 bits (199), Expect = 1e-15
Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 3/130 (2%)
Query: 154 QLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS 213
+++S+ + +L L L+L N++ IPP++ L +L YL L NK++S+P +L + S
Sbjct: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
Query: 214 LRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIR 273
LR L L+NNLL LP E+ L L+ L L+GNPL + + +L DP +L +
Sbjct: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL-SQDILNLYQDPDGTRKLL--NFMLD 160
Query: 274 NISYTPYDLP 283
N++ P LP
Sbjct: 161 NLAVHPEQLP 170
Score = 53.5 bits (127), Expect = 3e-07
Identities = 30/80 (37%), Positives = 44/80 (55%)
Query: 122 LQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEI 181
L L+L+ N +P + +L L L L N+L+S+PAE+ N+ SL L L N ++ +
Sbjct: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
Query: 182 PPELGNLPSLNYLVLCDNKI 201
P ELG L L L L N +
Sbjct: 118 PYELGRLFQLQTLGLKGNPL 137
Score = 38.5 bits (88), Expect = 0.010
Identities = 35/101 (34%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 55 RLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLA 114
R+ SL +L S HL L ++ N L+ + P++ L L L +N+L +LP L
Sbjct: 44 RVRSLSTSLWS-LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKL---RSLPAELG 99
Query: 115 QSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQL 155
SL+ L L+ N + +P L L LQTL L GN L
Sbjct: 100 NMV---SLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
Score = 30.8 bits (68), Expect = 2.0
Identities = 31/85 (36%), Positives = 38/85 (44%), Gaps = 7/85 (8%)
Query: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
L L L N L +P + +L LD+S N L +L EL + LR LL NN L
Sbjct: 58 LTALHLNDNYLSRIPPDIAK-LHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL-- 114
Query: 106 PSALPKGLAQSPLCRSLQVLNLSGN 130
LP L + LQ L L GN
Sbjct: 115 -RVLPYELGR---LFQLQTLGLKGN 135
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 4/153 (2%)
Query: 95 TLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQ 154
TL N RL P+G A+S + +LS N F EVP + +L +L+ LSL N
Sbjct: 46 TLNLSNRRL---KHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNC 102
Query: 155 LQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSL 214
L+ + + NL +L L L N + +PP + LP L L++ +NK+ ++PP + L SL
Sbjct: 103 LRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSL 161
Query: 215 RSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
R L + +N L LP E+ L L +L++R N L
Sbjct: 162 RQLDVSSNELQSLPSELCGLSSLRDLNVRRNQL 194
Score = 72.4 bits (176), Expect = 6e-13
Identities = 50/135 (37%), Positives = 75/135 (55%), Gaps = 3/135 (2%)
Query: 121 SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180
SL+ L+L NC + + +L L AL L+L NQL +P I L L L + N +
Sbjct: 92 SLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGA 150
Query: 181 IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREI--LNLIHLE 238
+PP++G L SL L + N++QS+P +L L SLR L++ N L+ LP E+ L L+ L+
Sbjct: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLD 210
Query: 239 ELSLRGNPLVVRFVR 253
R + + V F R
Sbjct: 211 FSCNRVSRIPVSFCR 225
Score = 67.8 bits (164), Expect = 2e-11
Identities = 60/173 (34%), Positives = 89/173 (51%), Gaps = 12/173 (6%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L HN L L ALG+ L L++S N L+ L P + L LR L+ NN+LG A
Sbjct: 96 LSLYHNCLRCLNPALGN-LTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLG---A 150
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
LP + SL+ L++S N Q +P+ L L +L+ L++ NQL ++P E+ +L +
Sbjct: 151 LPPDIGT---LGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV 207
Query: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQL---SQLHSLRSLS 218
L N + IP L L ++L N +QS P Q+ +LH + LS
Sbjct: 208 R-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLS 259
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 80.9 bits (198), Expect = 2e-15
Identities = 62/216 (28%), Positives = 97/216 (44%), Gaps = 18/216 (8%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L N+L LP+ + L+ LD+ N T + L L GL+ NRL
Sbjct: 166 LELRENQLKMLPKTMNR-LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 109 LPKGLAQSPL-----------------CRSLQVLNLSGNCFQEVPASLLELRALQTLSLG 151
L Q C +LQ L LS N Q++P ++ L+ + TL +
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKID 284
Query: 152 GNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQL 211
NQL +P I L S+E L N ++ +P +G L +L N +Q +PP++
Sbjct: 285 ENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSW 344
Query: 212 HSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
++ L LH+N L LP E+ ++ L+ ++L N L
Sbjct: 345 KNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 78.2 bits (191), Expect = 1e-14
Identities = 50/192 (26%), Positives = 96/192 (50%), Gaps = 7/192 (3%)
Query: 54 NRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGL 113
NRL +P +GS L LDVS N + + + L+ LL +N L LP+ +
Sbjct: 217 NRLTFIPGFIGS-LKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL---QQLPETI 272
Query: 114 AQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYL 173
+++ L + N +P S+ L +++ L N+++++P+ I L +L
Sbjct: 273 GS---LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAA 329
Query: 174 GGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILN 233
N+++++PPE+G+ ++ L L NK++++P ++ + L+ ++L +N L LP
Sbjct: 330 DHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Query: 234 LIHLEELSLRGN 245
L L + L N
Sbjct: 390 LQQLTAMWLSDN 401
Score = 76.3 bits (186), Expect = 4e-14
Identities = 61/225 (27%), Positives = 103/225 (45%), Gaps = 24/225 (10%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
++L +L LP N L +LP ++ + +L+ LDVS N + + + L + A N +
Sbjct: 69 QSLHKLSLPDNDLTTLPASIAN-LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPI 127
Query: 104 GGPSALPKGLAQS--------------------PLCRSLQVLNLSGNCFQEVPASLLELR 143
S LP G +Q LQ+L L N + +P ++ L
Sbjct: 128 ---SKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLT 184
Query: 144 ALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQS 203
L+ L LG N+ +P +E L L+ ++ N + IP +G+L L YL + N I+
Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244
Query: 204 IPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
+ +S +L+ L L +N L LP I +L ++ L + N L+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Score = 70.5 bits (171), Expect = 2e-12
Identities = 45/128 (35%), Positives = 65/128 (50%)
Query: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
++L+ L L N +E+P L ++L LSL N L ++PA I NL +L L + N I+
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
E P + N L + N I +P SQL +L L L++ L +LP L L+
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 240 LSLRGNPL 247
L LR N L
Sbjct: 166 LELRENQL 173
Score = 65.9 bits (159), Expect = 6e-11
Identities = 45/137 (32%), Positives = 65/137 (47%), Gaps = 3/137 (2%)
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
LPK L C+SL L+L N +PAS+ L L+ L + N +Q P I+N + L
Sbjct: 61 LPKQLFN---CQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLP 228
+ N I ++P L +L L L D ++ +P +L L+ L L N L LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 229 REILNLIHLEELSLRGN 245
+ + L LE L L N
Sbjct: 178 KTMNRLTQLERLDLGSN 194
Score = 58.9 bits (141), Expect = 7e-09
Identities = 51/194 (26%), Positives = 85/194 (43%), Gaps = 8/194 (4%)
Query: 37 EERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTL 96
EE E L LLL N L LP +GS ++ L + N L L + L + L
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGS-LKNITTLKIDENQLMYLPDSIGGLISVEEL 304
Query: 97 LAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQ 156
N + ALP + Q +L+ N Q++P + + + L L N+L+
Sbjct: 305 DCSFNEV---EALPSSIGQ---LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE 358
Query: 157 SIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS-LR 215
++P E+ ++Q L+ + L N +K +P L L + L DN+ + + P + S +
Sbjct: 359 TLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQ 418
Query: 216 SLSLHNNLLTYLPR 229
+ L N + PR
Sbjct: 419 KMVLTNYMFPQQPR 432
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 80.9 bits (198), Expect = 2e-15
Identities = 62/216 (28%), Positives = 97/216 (44%), Gaps = 18/216 (8%)
Query: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
L L N+L LP+ + L+ LD+ N T + L L GL+ NRL
Sbjct: 166 LELRENQLKMLPKTMNR-LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 109 LPKGLAQSPL-----------------CRSLQVLNLSGNCFQEVPASLLELRALQTLSLG 151
L Q C +LQ L LS N Q++P ++ L+ + TL +
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKID 284
Query: 152 GNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQL 211
NQL +P I L S+E L N ++ +P +G L +L N +Q +PP++
Sbjct: 285 ENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSW 344
Query: 212 HSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
++ L LH+N L LP E+ ++ L+ ++L N L
Sbjct: 345 KNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 78.2 bits (191), Expect = 1e-14
Identities = 50/192 (26%), Positives = 96/192 (50%), Gaps = 7/192 (3%)
Query: 54 NRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGL 113
NRL +P +GS L LDVS N + + + L+ LL +N L LP+ +
Sbjct: 217 NRLTFIPGFIGS-LKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL---QQLPETI 272
Query: 114 AQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYL 173
+++ L + N +P S+ L +++ L N+++++P+ I L +L
Sbjct: 273 GS---LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAA 329
Query: 174 GGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILN 233
N+++++PPE+G+ ++ L L NK++++P ++ + L+ ++L +N L LP
Sbjct: 330 DHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Query: 234 LIHLEELSLRGN 245
L L + L N
Sbjct: 390 LQQLTAMWLSDN 401
Score = 76.3 bits (186), Expect = 4e-14
Identities = 61/225 (27%), Positives = 103/225 (45%), Gaps = 24/225 (10%)
Query: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
++L +L LP N L +LP ++ + +L+ LDVS N + + + L + A N +
Sbjct: 69 QSLHKLSLPDNDLTTLPASIAN-LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPI 127
Query: 104 GGPSALPKGLAQS--------------------PLCRSLQVLNLSGNCFQEVPASLLELR 143
S LP G +Q LQ+L L N + +P ++ L
Sbjct: 128 ---SKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLT 184
Query: 144 ALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQS 203
L+ L LG N+ +P +E L L+ ++ N + IP +G+L L YL + N I+
Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244
Query: 204 IPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
+ +S +L+ L L +N L LP I +L ++ L + N L+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Score = 70.5 bits (171), Expect = 2e-12
Identities = 45/128 (35%), Positives = 65/128 (50%)
Query: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
++L+ L L N +E+P L ++L LSL N L ++PA I NL +L L + N I+
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
E P + N L + N I +P SQL +L L L++ L +LP L L+
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 240 LSLRGNPL 247
L LR N L
Sbjct: 166 LELRENQL 173
Score = 65.9 bits (159), Expect = 6e-11
Identities = 45/137 (32%), Positives = 65/137 (47%), Gaps = 3/137 (2%)
Query: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
LPK L C+SL L+L N +PAS+ L L+ L + N +Q P I+N + L
Sbjct: 61 LPKQLFN---CQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLP 228
+ N I ++P L +L L L D ++ +P +L L+ L L N L LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 229 REILNLIHLEELSLRGN 245
+ + L LE L L N
Sbjct: 178 KTMNRLTQLERLDLGSN 194
Score = 58.9 bits (141), Expect = 7e-09
Identities = 51/194 (26%), Positives = 85/194 (43%), Gaps = 8/194 (4%)
Query: 37 EERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTL 96
EE E L LLL N L LP +GS ++ L + N L L + L + L
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGS-LKNITTLKIDENQLMYLPDSIGGLISVEEL 304
Query: 97 LAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQ 156
N + ALP + Q +L+ N Q++P + + + L L N+L+
Sbjct: 305 DCSFNEV---EALPSSIGQ---LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE 358
Query: 157 SIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS-LR 215
++P E+ ++Q L+ + L N +K +P L L + L DN+ + + P + S +
Sbjct: 359 TLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQ 418
Query: 216 SLSLHNNLLTYLPR 229
+ L N + PR
Sbjct: 419 KMVLTNYMFPQQPR 432
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,749,777
Number of Sequences: 37866
Number of extensions: 695423
Number of successful extensions: 4030
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 2484
Number of HSP's gapped (non-prelim): 876
length of query: 371
length of database: 18,247,518
effective HSP length: 104
effective length of query: 267
effective length of database: 14,309,454
effective search space: 3820624218
effective search space used: 3820624218
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.