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Search of human proteins with 153218654
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153218654 cytochrome P450, family 11, subfamily A,
polypeptide 1 isoform b [Homo sapiens]
(363 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 734 0.0
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 734 0.0
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 254 6e-68
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 244 7e-65
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 181 9e-46
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 174 1e-43
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 172 6e-43
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 164 9e-41
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 164 1e-40
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 119 6e-27
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 100 2e-21
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 97 2e-20
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 93 4e-19
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 92 6e-19
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 92 7e-19
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 91 2e-18
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 89 8e-18
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 89 8e-18
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 88 1e-17
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 86 4e-17
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 86 4e-17
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 83 3e-16
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 81 2e-15
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide... 77 2e-14
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 76 4e-14
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 76 4e-14
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 75 9e-14
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 74 2e-13
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 74 2e-13
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 74 2e-13
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 734 bits (1894), Expect = 0.0
Identities = 363/363 (100%), Positives = 363/363 (100%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER
Sbjct: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD
Sbjct: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
Query: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH
Sbjct: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Query: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL
Sbjct: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
Query: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG
Sbjct: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
Query: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 360
VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA
Sbjct: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 360
Query: 361 TQQ 363
TQQ
Sbjct: 361 TQQ 363
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 734 bits (1894), Expect = 0.0
Identities = 363/363 (100%), Positives = 363/363 (100%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER
Sbjct: 159 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 218
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD
Sbjct: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278
Query: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH
Sbjct: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338
Query: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL
Sbjct: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398
Query: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG
Sbjct: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458
Query: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 360
VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA
Sbjct: 459 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEA 518
Query: 361 TQQ 363
TQQ
Sbjct: 519 TQQ 521
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 254 bits (650), Expect = 6e-68
Identities = 140/357 (39%), Positives = 209/357 (58%), Gaps = 2/357 (0%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
++P+A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER
Sbjct: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D
Sbjct: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268
Query: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Q Y EL H Y GI+ LL +++S E IKAN E+ AG VDTT+ L
Sbjct: 269 NCIQKIYQELAFNRPQH--YTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMT 326
Query: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
L+E+ARN VQ +LR E LAA +PLL+A++KETLRL+P+ + L+R +
Sbjct: 327 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVV 386
Query: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
+DLVL++Y IPA TLVQV +Y+LGR F PE ++P RWL + F ++ FG+G
Sbjct: 387 SSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFG 446
Query: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 357
+RQCLGRR+AE EM + L ++L++F VE D+ ++ IL P TF N
Sbjct: 447 MRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 244 bits (624), Expect = 7e-65
Identities = 137/357 (38%), Positives = 206/357 (57%), Gaps = 2/357 (0%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER
Sbjct: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D
Sbjct: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268
Query: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L
Sbjct: 269 NCIQKIYQELAF--SRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326
Query: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R
Sbjct: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386
Query: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
+DLVL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+G
Sbjct: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446
Query: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 357
+RQCLGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N
Sbjct: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 181 bits (459), Expect = 9e-46
Identities = 122/361 (33%), Positives = 185/361 (51%), Gaps = 9/361 (2%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHR-RIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 59
+ P+A + L+ V D V L R R + G D++ + ++F E I V+ G
Sbjct: 146 LRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGS 205
Query: 60 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 119
R G LE V P+ + FI A+ +F +++ + +P L L W WD +F+ A
Sbjct: 206 RLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLV-PGPWGRLCRDWDQMFAFA 264
Query: 120 DIYTQNFYWE--LRQKGSVHHDYRG--ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSM 175
+ + E +R G D L L ++ + I NVTE+L GVDT S
Sbjct: 265 QRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSN 324
Query: 176 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQG--DMATMLQLVPLLKASIKETLRLHPIS 233
TL W LYE++R+ +VQ L +E+ AA AT+L +PLLKA +KE LRL+P+
Sbjct: 325 TLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVV 384
Query: 234 VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFR 293
R D+ + DY+IP TLV + YA R+P F +P +F P RWL + F
Sbjct: 385 PGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFA 444
Query: 294 NLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ-HLSDVGTTFNLILMPEKPISFT 352
+L FG+G R C+GRR+AELE+ + L +L +F V+ + + V +L+PE+ I+
Sbjct: 445 SLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQ 504
Query: 353 F 353
F
Sbjct: 505 F 505
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 174 bits (440), Expect = 1e-43
Identities = 108/363 (29%), Positives = 184/363 (50%), Gaps = 12/363 (3%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
+ P + + V DF++ L + ++ SGN D++ + FA E+I ++F +R
Sbjct: 166 LKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKR 225
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA- 119
G L+ + + F+ +I MF S+ LP + WK ++ W+ IFS
Sbjct: 226 IGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVL--PFWKRYLDGWNAIFSFGK 283
Query: 120 ---DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 176
D ++ +L+ G G L+ LL ++S + ++ E+L GVDTTS T
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNT 343
Query: 177 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 236
L W LY ++++ ++Q+ L EV+ Q +PLLKA +KETLRL+P+ T
Sbjct: 344 LTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTN 403
Query: 237 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT-----Y 291
R + ++ + ++ P T Y + R+PT F +PE+F P RWL + T
Sbjct: 404 SRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHP 463
Query: 292 FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-QHLSDVGTTFNLILMPEKPIS 350
F ++ FG+GVR CLGRRIAELEM + L +++ ++V + ++ + ++L+P K +
Sbjct: 464 FGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVG 523
Query: 351 FTF 353
F
Sbjct: 524 LQF 526
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 172 bits (435), Expect = 6e-43
Identities = 98/267 (36%), Positives = 150/267 (56%), Gaps = 2/267 (0%)
Query: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER
Sbjct: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208
Query: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D
Sbjct: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268
Query: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L
Sbjct: 269 NCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326
Query: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R
Sbjct: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386
Query: 241 VNDLVLRDYMIPAKTLVQVAIYALGRE 267
+DLVL++Y IPA L + + L +E
Sbjct: 387 SSDLVLQNYHIPAGVLKHLQVETLTQE 413
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 164 bits (416), Expect = 9e-41
Identities = 108/348 (31%), Positives = 180/348 (51%), Gaps = 8/348 (2%)
Query: 13 LDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA 72
++ V D + ++ +A G +++D F+++ E + +++ R G LE +
Sbjct: 22 VNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLT 81
Query: 73 QRFIDAI---YQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE 129
+I+A+ + MF TS+ +P L R F K W++ +WD +F + I+ N +
Sbjct: 82 VEYIEALELMFSMFKTSMYAGAIPRWL-RPFIPKPWREFCRSWDGLFKFSQIHVDNKLRD 140
Query: 130 LR-QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 188
++ Q G+L L ++ ++I ANVTEML GVDTTS TL W +Y +AR+
Sbjct: 141 IQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHP 200
Query: 189 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 248
+VQ + E++ + A + VPL++A +KETLRL P+ R DLV+
Sbjct: 201 EVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGG 260
Query: 249 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD--KNITYFRNLGFGWGVRQCLG 306
Y+IP T + + YA + F + F P RWL K + F ++ FG GVR C+G
Sbjct: 261 YLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIG 320
Query: 307 RRIAELEMTIFLINMLENFRVEIQHLSD-VGTTFNLILMPEKPISFTF 353
RRIAELE+ + +I +L++F ++ ++ V + +L P PI F
Sbjct: 321 RRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRF 368
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 164 bits (414), Expect = 1e-40
Identities = 104/315 (33%), Positives = 165/315 (52%), Gaps = 7/315 (2%)
Query: 39 DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 98
D+ +L +++FESI V++ +R G+L++ EA FI AI M T M+ P +L +
Sbjct: 202 DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHK 261
Query: 99 LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 158
TK W+DH AWD IF N + Q+ S D+ +Y +++S +++
Sbjct: 262 SLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA--DFLCDIYH---QNRLSKKEL 316
Query: 159 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 218
A VTE+ V+TT+ +L W LY ++RN +VQ L E+ + + Q A L+ +P
Sbjct: 317 YAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPY 376
Query: 219 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 278
LKA +KE++RL P R L VL +Y +P T++ + LG F D F
Sbjct: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFR 436
Query: 279 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 338
P RWL + + I F +L FG G R C+GRR+AEL++ + L ++ + ++ V
Sbjct: 437 PERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEML 496
Query: 339 FNLILMP--EKPISF 351
+ L+P E PI+F
Sbjct: 497 HSGTLVPSRELPIAF 511
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 119 bits (297), Expect = 6e-27
Identities = 79/245 (32%), Positives = 124/245 (50%), Gaps = 5/245 (2%)
Query: 39 DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 98
D+ +L +++FESI V++ +R G+L++ EA FI AI M T M+ P +L +
Sbjct: 202 DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHK 261
Query: 99 LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 158
TK W+DH AWD IF N + Q+ S D+ +Y +++S +++
Sbjct: 262 SLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA--DFLCDIYH---QNRLSKKEL 316
Query: 159 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 218
A VTE+ V+TT+ +L W LY ++RN +VQ L E+ + + Q A L+ +P
Sbjct: 317 YAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPY 376
Query: 219 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 278
LKA +KE++RL P R L VL +Y +P + + I A EP
Sbjct: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLV 436
Query: 279 PTRWL 283
P+R L
Sbjct: 437 PSREL 441
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 100 bits (249), Expect = 2e-21
Identities = 65/185 (35%), Positives = 102/185 (55%), Gaps = 5/185 (2%)
Query: 169 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR-HQAQGDMATMLQLVPLLKASIKETL 227
G +TTS L + +YE+A + VQ L+ E+ A ++A T+LQ+ L + ETL
Sbjct: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM-EYLDMVVNETL 364
Query: 228 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 287
RL PI++ L+R D+ + IP +V + YAL R+P ++ +PE F P R+ K+K
Sbjct: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424
Query: 288 -NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--ILM 344
NI + FG G R C+G R A + M + LI +L+NF + + + +L +L
Sbjct: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484
Query: 345 PEKPI 349
PEKP+
Sbjct: 485 PEKPV 489
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 97.4 bits (241), Expect = 2e-20
Identities = 59/195 (30%), Positives = 97/195 (49%), Gaps = 2/195 (1%)
Query: 157 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLV 216
++ A + G +TTS L + LYE+A + VQ L+ E+ A + +
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353
Query: 217 PLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 276
L + ETLRL P+++ L+R D+ + IP ++V + YAL +P ++ +PE
Sbjct: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413
Query: 277 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVG 336
F P R+ K +I + FG G R C+G R A + M + LI +L+NF + + +
Sbjct: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473
Query: 337 TTFNL--ILMPEKPI 349
+ +L PEKPI
Sbjct: 474 LKLDTQGLLQPEKPI 488
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 92.8 bits (229), Expect = 4e-19
Identities = 63/185 (34%), Positives = 97/185 (52%), Gaps = 6/185 (3%)
Query: 152 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 208
++S EDI+A + GG DTT+ L W LY +AR+ + Q+ R EV L R + +
Sbjct: 312 ELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIE 371
Query: 209 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 267
+ QL P L +KE+LRLHP T R D+VL D +IP + + I+A+
Sbjct: 372 WDDLAQL-PFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHN 430
Query: 268 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 326
P+ + DPE +DP R+ ++ + + + F G R C+G++ A EM + L L FR
Sbjct: 431 PSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFR 490
Query: 327 VEIQH 331
+ H
Sbjct: 491 ILPDH 495
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 92.4 bits (228), Expect = 6e-19
Identities = 63/182 (34%), Positives = 92/182 (50%), Gaps = 3/182 (1%)
Query: 171 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 230
DTTS TL + +YE+A + VQ L+ E+ A L + L + ETLRL
Sbjct: 308 DTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLF 367
Query: 231 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK-NI 289
P+ + R D+ + IP V V IYAL +P ++ +PE F P R+ K+K +I
Sbjct: 368 PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSI 427
Query: 290 TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NL-ILMPEK 347
+R + FG G R C+G R A + + +I L+NF + + + NL IL PEK
Sbjct: 428 DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEK 487
Query: 348 PI 349
PI
Sbjct: 488 PI 489
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 92.0 bits (227), Expect = 7e-19
Identities = 61/197 (30%), Positives = 102/197 (51%), Gaps = 5/197 (2%)
Query: 157 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV-LAARHQAQGDMATMLQL 215
++ A + G +TTS L + +YE+A + VQ ++ E+ ++A T+LQL
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353
Query: 216 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 275
L + ETLRL P+++ L+R D+ + IP +V + Y L +P ++ +PE
Sbjct: 354 -EYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412
Query: 276 NFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD 334
F P R+ K+K NI + FG G R C+G R A + M + L+ +L+NF + +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQ 472
Query: 335 V--GTTFNLILMPEKPI 349
+ F +L+ EKPI
Sbjct: 473 IPLKLRFGGLLLTEKPI 489
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 90.9 bits (224), Expect = 2e-18
Identities = 69/210 (32%), Positives = 101/210 (48%), Gaps = 7/210 (3%)
Query: 153 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGDM 209
+S EDI+A + GG DTT+ L W LY +AR+ + Q+ R EV L R + +
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
Query: 210 ATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREP 268
+ QL P L +KE+LRLHP + + R D+VL D +IP + I + P
Sbjct: 373 DDLAQL-PFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNP 431
Query: 269 TFFFDPENFDPTRW-LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 327
T + DPE +DP R+ K + + F G R C+G+ A EM + L ML +FR
Sbjct: 432 TVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491
Query: 328 EIQHLSDVGTTFNLILMPEKPISFTFWPFN 357
H ++ LI+ E + P N
Sbjct: 492 LPDH-TEPRRKLELIMRAEGGLWLRVEPLN 520
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 88.6 bits (218), Expect = 8e-18
Identities = 63/183 (34%), Positives = 93/183 (50%), Gaps = 4/183 (2%)
Query: 171 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 230
DTTS TL + +YE+A + VQ L+ E+ A L + L + ETLRL
Sbjct: 308 DTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLF 367
Query: 231 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP-TRWLSKDK-N 288
P+ + R D+ + IP V V IYAL +P ++ +PE F P +R+ K+K +
Sbjct: 368 PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDS 427
Query: 289 ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NL-ILMPE 346
I +R + FG G R C+G R A + + +I L+NF + + + NL IL PE
Sbjct: 428 IDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPE 487
Query: 347 KPI 349
KPI
Sbjct: 488 KPI 490
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 88.6 bits (218), Expect = 8e-18
Identities = 63/185 (34%), Positives = 93/185 (50%), Gaps = 6/185 (3%)
Query: 152 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 208
K+S EDI+A + G DTT+ L W LY +A++ + Q+ R EV L R + +
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 209 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 267
+ QL P L IKE+LRLHP + R D+VL D +IP + ++++
Sbjct: 372 WDDLAQL-PFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHN 430
Query: 268 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 326
P + DPE +DP R+ K+ K + + F G R C+G+ A EM + L L FR
Sbjct: 431 PAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFR 490
Query: 327 VEIQH 331
V H
Sbjct: 491 VLPDH 495
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/185 (32%), Positives = 94/185 (50%), Gaps = 6/185 (3%)
Query: 152 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 208
K+S EDI+A + G DTT+ L W LY +A++ + Q+ R EV L R + +
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 209 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 267
+ L P L +KE+LRLHP + R++ D+VL D +IP + ++++
Sbjct: 372 WDDLAHL-PFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430
Query: 268 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 326
P + DPE +DP R+ ++ K + + F G R C+G+ A EM + L L FR
Sbjct: 431 PAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR 490
Query: 327 VEIQH 331
V H
Sbjct: 491 VLPDH 495
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/185 (33%), Positives = 93/185 (50%), Gaps = 6/185 (3%)
Query: 152 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 208
++S EDI+A + G DTT+ L W LY +A++ + Q+ R EV L R + +
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 209 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 267
+ QL P L IKE+LRLHP + R D VL D +IP + + I +
Sbjct: 372 WDDLAQL-PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYN 430
Query: 268 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 326
PT + DPE +DP R+ ++ K + + F G R C+G+ A EM + L L +FR
Sbjct: 431 PTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFR 490
Query: 327 VEIQH 331
+ H
Sbjct: 491 ILPTH 495
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/185 (33%), Positives = 93/185 (50%), Gaps = 6/185 (3%)
Query: 152 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD 208
++S EDI+A + G DTT+ L W LY +A++ + Q+ R EV L R + +
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 209 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGRE 267
+ QL P L IKE+LRLHP + R D VL D +IP + + I +
Sbjct: 372 WDDLAQL-PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYN 430
Query: 268 PTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 326
PT + DPE +DP R+ ++ K + + F G R C+G+ A EM + L L +FR
Sbjct: 431 PTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFR 490
Query: 327 VEIQH 331
+ H
Sbjct: 491 ILPTH 495
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 83.2 bits (204), Expect = 3e-16
Identities = 81/296 (27%), Positives = 131/296 (44%), Gaps = 22/296 (7%)
Query: 75 FIDAIYQMFHTSVPMLNLP---PDLFRLFRTKTWKD-------HVAAWDVIFSKADIYTQ 124
++ A+Y+M + +P DL+ L + W+ H VI +A+
Sbjct: 219 YVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNA 278
Query: 125 NFYWELRQKGSV--HHDYRGILYRLLG-----DSKMSFEDIKANVTEMLAGGVDTTSMTL 177
N +GS + R L LL +++S EDI+ V + G DTT+ +
Sbjct: 279 NEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAI 338
Query: 178 QWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL--LKASIKETLRLHPISVT 235
W LY + N +VQ + E+ ++ AT+ L L L+ IKETLRL P
Sbjct: 339 NWSLYLLGSNPEVQKKVDHELDDVFGKSDRP-ATVEDLKKLRYLECVIKETLRLFPSVPL 397
Query: 236 LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY-FRN 294
R + D + Y + T + YAL R+P +F +PE F P R+ ++ + +
Sbjct: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457
Query: 295 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-QHLSDVGTTFNLILMPEKPI 349
+ F G R C+G++ A +E L +L +F +E Q ++G LIL P I
Sbjct: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGI 513
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 80.9 bits (198), Expect = 2e-15
Identities = 51/180 (28%), Positives = 90/180 (50%), Gaps = 3/180 (1%)
Query: 149 GDSKMSF--EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQ 206
G+ SF E++ + ++ G +TTS TL+W L MA ++Q+ ++AE+ Q Q
Sbjct: 290 GNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ 349
Query: 207 GDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 265
+ +P A I E R+ + I + + R + D L Y +P T++ + AL
Sbjct: 350 QPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALH 409
Query: 266 REPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 325
R+PT + P+ F+P +L + + F G R CLG ++A E+ IF ++++ F
Sbjct: 410 RDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
[Homo sapiens]
Length = 543
Score = 77.0 bits (188), Expect = 2e-14
Identities = 56/209 (26%), Positives = 103/209 (49%), Gaps = 16/209 (7%)
Query: 149 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE----VLAARHQ 204
G +++ E++ A +T++ DT S LQW L R VQ ++AE V R
Sbjct: 311 GGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLP 370
Query: 205 AQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 263
GD + P + A + E +R + VT+ + + Y IP T+V V ++
Sbjct: 371 CMGDQPNL----PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 426
Query: 264 LGREPTFFFDPENFDPTRWLSKD----KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 319
+ +P + +PENFDP R+L KD K++T R + F G R+C+G ++++++ +F+
Sbjct: 427 VNHDPLKWPNPENFDPARFLDKDGLINKDLT-SRVMIFSVGKRRCIGEELSKMQLFLFIS 485
Query: 320 NMLE--NFRVEIQHLSDVGTTFNLILMPE 346
+ +FR + + ++ L + P+
Sbjct: 486 ILAHQCDFRANPNEPAKMNFSYGLTIKPK 514
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 76.3 bits (186), Expect = 4e-14
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Query: 153 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQGDMA 210
++ ++I L G + + TL + Y +A N Q+ L EV +H A +
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFC 385
Query: 211 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 270
++ + +P L I ETLR++P + R D + IPA ++++A+ AL +P
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 271 FFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 328
+ PE F+P R+ ++ + F L FG G R CLG R+ LE+ + L+++L FR +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 76.3 bits (186), Expect = 4e-14
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Query: 153 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQGDMA 210
++ ++I L G + + TL + Y +A N Q+ L EV +H A +
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFC 385
Query: 211 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 270
++ + +P L I ETLR++P + R D + IPA ++++A+ AL +P
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 271 FFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 328
+ PE F+P R+ ++ + F L FG G R CLG R+ LE+ + L+++L FR +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 75.1 bits (183), Expect = 9e-14
Identities = 56/195 (28%), Positives = 92/195 (47%), Gaps = 4/195 (2%)
Query: 137 HHDYRGILYRLLGDSKMSFEDIKAN--VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDML 194
+ D+ I+ +S SF DI + V+ L G DT + ++ W LY +A N + Q+
Sbjct: 283 YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERC 342
Query: 195 RAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPA 253
R EV L + IKET RL P ++ R L L D +PA
Sbjct: 343 REEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA 402
Query: 254 KTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY-FRNLGFGWGVRQCLGRRIAEL 312
V ++I+ L P + +P+ FDP R+ ++ + + + L F G R C+G+ A +
Sbjct: 403 GITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMI 462
Query: 313 EMTIFLINMLENFRV 327
E+ + + +L +FRV
Sbjct: 463 ELKVTIALILLHFRV 477
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/188 (28%), Positives = 91/188 (48%), Gaps = 14/188 (7%)
Query: 151 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR----NLKVQDMLRAEVLAARHQAQ 206
S+ + E + A VT+M G +TTS TL++ L + + KVQ+ + V R
Sbjct: 221 SEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCM 280
Query: 207 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 265
D + M P A + E R + + L + D+ ++Y+IP T + ++ ++
Sbjct: 281 QDRSHM----PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 336
Query: 266 REPTFFFDPENFDPTRWLSKDKNIT---YFRNLGFGWGVRQCLGRRIAELEMTIFLINML 322
F +PE FDP +L K N YF + F G R C+G +A +E+ +FL +L
Sbjct: 337 HNDKEFPNPEMFDPGHFLDKSGNFKKSDYF--MPFSAGKRMCMGEGLARMELFLFLTTIL 394
Query: 323 ENFRVEIQ 330
+NF ++ Q
Sbjct: 395 QNFNLKSQ 402
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/188 (28%), Positives = 91/188 (48%), Gaps = 14/188 (7%)
Query: 151 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR----NLKVQDMLRAEVLAARHQAQ 206
S+ + E + A VT+M G +TTS TL++ L + + KVQ+ + V R
Sbjct: 280 SEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCM 339
Query: 207 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 265
D + M P A + E R + + L + D+ ++Y+IP T + ++ ++
Sbjct: 340 QDRSHM----PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVL 395
Query: 266 REPTFFFDPENFDPTRWLSKDKNIT---YFRNLGFGWGVRQCLGRRIAELEMTIFLINML 322
F +PE FDP +L K N YF + F G R C+G +A +E+ +FL +L
Sbjct: 396 HNDKEFPNPEMFDPGHFLDKSGNFKKSDYF--MPFSAGKRMCMGEGLARMELFLFLTTIL 453
Query: 323 ENFRVEIQ 330
+NF ++ Q
Sbjct: 454 QNFNLKSQ 461
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 74.3 bits (181), Expect = 2e-13
Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 4/197 (2%)
Query: 139 DYRGILYRLLGDSKMSFE--DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 196
D+ IL ++ F D++A V + G DTTS + W LY +A+ + Q R
Sbjct: 283 DFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRD 342
Query: 197 EVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKT 255
E+ L +P IKE LRL+ V + R L + D +PA
Sbjct: 343 EIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGI 402
Query: 256 LVQVAIYALGREPTFFFDPENFDPTRWLSKD-KNITYFRNLGFGWGVRQCLGRRIAELEM 314
V + I+AL P F+ DP+ F+P R+ ++ + I + + F G+R C+G+ A +E
Sbjct: 403 TVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIEC 462
Query: 315 TIFLINMLENFRVEIQH 331
+ + L F++ H
Sbjct: 463 KVAVALTLLRFKLAPDH 479
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,399,874
Number of Sequences: 37866
Number of extensions: 497172
Number of successful extensions: 1312
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1147
Number of HSP's gapped (non-prelim): 85
length of query: 363
length of database: 18,247,518
effective HSP length: 104
effective length of query: 259
effective length of database: 14,309,454
effective search space: 3706148586
effective search space used: 3706148586
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.