Search of human proteins with 15147328

Search of human proteins with 15147328

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide
7 isoform 2 [Homo sapiens]
         (443 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   884   0.0  
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   857   0.0  
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   808   0.0  
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   790   0.0  
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   435   e-122
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   425   e-119
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   415   e-116
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   414   e-116
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   411   e-115
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   410   e-114
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   394   e-109
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   374   e-103
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   352   3e-97
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   330   2e-90
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   268   1e-71
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   264   1e-70
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   251   1e-66
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   248   8e-66
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   229   3e-60
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   188   1e-47
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   161   1e-39
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   160   2e-39
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  140   2e-33
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   116   5e-26
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   116   5e-26
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   111   2e-24
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   102   5e-22
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   102   9e-22
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   102   9e-22
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    96   7e-20

>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  884 bits (2285), Expect = 0.0
 Identities = 443/443 (100%), Positives = 443/443 (100%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  VSQGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPT 120
           VSQGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPT
Sbjct: 61  VSQGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPT 120

Query: 121 FFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLP 180
           FFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLP
Sbjct: 121 FFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLP 180

Query: 181 GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNL 240
           GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNL
Sbjct: 181 GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNL 240

Query: 241 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPY 300
           MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPY
Sbjct: 241 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPY 300

Query: 301 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDF 360
           MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDF
Sbjct: 301 MEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDF 360

Query: 361 NPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDI 420
           NPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDI
Sbjct: 361 NPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDI 420

Query: 421 DVSPKHVVFATIPRNYTMSFLPR 443
           DVSPKHVVFATIPRNYTMSFLPR
Sbjct: 421 DVSPKHVVFATIPRNYTMSFLPR 443


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  857 bits (2215), Expect = 0.0
 Identities = 441/494 (89%), Positives = 442/494 (89%), Gaps = 51/494 (10%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  VSQ---------------------------------------------------GVAFSN 69
            S+                                                   GVAFSN
Sbjct: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120

Query: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129
           GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180

Query: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189
           VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240

Query: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249
           LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300

Query: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360

Query: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420

Query: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480

Query: 430 ATIPRNYTMSFLPR 443
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  808 bits (2086), Expect = 0.0
 Identities = 412/494 (83%), Positives = 431/494 (87%), Gaps = 51/494 (10%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASG+LLVALL CLTVMVLMSVWQQRKS+GKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  VSQ---------------------------------------------------GVAFSN 69
           +S+                                                   GV FSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120

Query: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129
           GERAKQL RF+IATLRDFGVGKRGIEERIQEE+GFLI+A+R T GANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180

Query: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189
           VISSIVFGDRFDY+DKEFLSLL MMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF+L
Sbjct: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240

Query: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300

Query: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPYMEAVIHEIQ
Sbjct: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360

Query: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEV+PMLGSVLRDPSFFSNPQDFNPQHFL++K
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420

Query: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480

Query: 430 ATIPRNYTMSFLPR 443
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  790 bits (2039), Expect = 0.0
 Identities = 403/494 (81%), Positives = 421/494 (85%), Gaps = 51/494 (10%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLV LLACLTVMVLMSVW+QRKSRGKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  VSQ---------------------------------------------------GVAFSN 69
           +S+                                                   GVAFSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120

Query: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129
           GERAKQL RF+IATLR FGVGKRGIEERIQEE+GFLI+A+R THGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180

Query: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189
           VISSIVFGDRFDYEDKEFLSLL MMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAFK 
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240

Query: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLF 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300

Query: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPY EAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360

Query: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369
           RFGD++PM LA RV KDTKFRDFFLPKGTEVFPMLGSVLRDP FFSNP+DFNPQHFLD K
Sbjct: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420

Query: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480

Query: 430 ATIPRNYTMSFLPR 443
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  435 bits (1118), Expect = e-122
 Identities = 217/489 (44%), Positives = 308/489 (62%), Gaps = 51/489 (10%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ-- 63
           L ++  LA LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++  +  
Sbjct: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62

Query: 64  -------------------------------------------------GVAFSNGERAK 74
                                                            GV F+NG R K
Sbjct: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122

Query: 75  QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 134
            L RF++ T+RDFG+GKR +EERIQEE+  LIE +R + GA +DPTF      +N+I SI
Sbjct: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182

Query: 135 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLE 194
           VFG RF Y+D+EFL +L++    F   S+  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242

Query: 195 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTET 254
            +I   VE ++ TLDP++P+D ID++L+HM++E+ N ++EF  +NL ++TL+LF AGTET
Sbjct: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302

Query: 255 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 314
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DR KMPY EAVI+EIQRF D+
Sbjct: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362

Query: 315 IPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK 374
           +PM +   V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422

Query: 375 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPR 434
           ++AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+      IP 
Sbjct: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482

Query: 435 NYTMSFLPR 443
            Y + FLPR
Sbjct: 483 TYQIRFLPR 491


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  425 bits (1092), Expect = e-119
 Identities = 218/485 (44%), Positives = 306/485 (63%), Gaps = 51/485 (10%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           V L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ++ + +  S+  +S+     
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 64  ----------------------------------------------GVAFSNGERAKQLL 77
                                                         G+ FSNG+R K++ 
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197
            RFDY+D++FL+L+  +    +  ST   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257
            +KV+ +Q ++D N+P+DFID FLI M++E++N  +EF ++NL+++  +L  AGTET ST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFLD+ G FKKS+ 
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P    FA++P  Y 
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 438 MSFLP 442
           + F+P
Sbjct: 485 LCFIP 489


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  415 bits (1067), Expect = e-116
 Identities = 213/485 (43%), Positives = 301/485 (62%), Gaps = 51/485 (10%)

Query: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ------ 63
           A+L  L  +V + +    + +GKLPPGP PL  +GN L L ++ +  S+ K+S+      
Sbjct: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66

Query: 64  ---------------------------------------------GVAFSNGERAKQLLR 78
                                                        G+AFS+G+R K L +
Sbjct: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126

Query: 79  FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 138
           F+I  LR+FG+GKR IEERI EE  FL+  +R T G   DPTF LSR+VSN+I S++FG 
Sbjct: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186

Query: 139 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 198
           RFDY+D+  L+++ ++   FQ  S+  G+LY++F S++  +PGP Q+ F+  + L D IA
Sbjct: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246

Query: 199 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 258
             V  +Q +LDP SP+DFI  FL  M EE+++P + F++  L+M+T NL   GT+TVSTT
Sbjct: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306

Query: 259 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 318
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DR  MPY +AVIHE+QRF D+IPM+
Sbjct: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366

Query: 319 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 378
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFLD    FKKS AF
Sbjct: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426

Query: 379 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 438
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P       +PR + +
Sbjct: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486

Query: 439 SFLPR 443
              PR
Sbjct: 487 CLRPR 491


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  414 bits (1064), Expect = e-116
 Identities = 213/486 (43%), Positives = 304/486 (62%), Gaps = 51/486 (10%)

Query: 8   LVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ---- 63
           LV L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ+  + I  S+  +S+    
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 64  -----------------------------------------------GVAFSNGERAKQL 76
                                                          G+ FSNG++ K++
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 77  LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 136
            RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 137 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 196
             RFDY+D++FL+L+  +    +  S+   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243

Query: 197 IAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVS 256
           I +KV+ +Q ++D N+PQDFID FL+ M++E+ N  +EF +++L  + ++LF AGTET S
Sbjct: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303

Query: 257 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIP 316
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363

Query: 317 MSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSD 376
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFLD+ G FKKS 
Sbjct: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423

Query: 377 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNY 436
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P    FA++P  Y
Sbjct: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483

Query: 437 TMSFLP 442
            + F+P
Sbjct: 484 QLCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  411 bits (1057), Expect = e-115
 Identities = 209/485 (43%), Positives = 301/485 (62%), Gaps = 51/485 (10%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+   S+     
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 64  ----------------------------------------------GVAFSNGERAKQLL 77
                                                         G+ FSNG+R K++ 
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197
           DRFDY+D+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244

Query: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257
            ++++ +Q +LD NS +DFID FLI M++E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304

Query: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364

Query: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424

Query: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484

Query: 438 MSFLP 442
           + F+P
Sbjct: 485 LCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  410 bits (1053), Expect = e-114
 Identities = 213/485 (43%), Positives = 295/485 (60%), Gaps = 51/485 (10%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           V L+ CL+ M+L S+W+Q   R KLPPGPTPLP IGN LQ++ + IC S    S+     
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 64  ----------------------------------------------GVAFSNGERAKQLL 77
                                                         G+  SNG+R K++ 
Sbjct: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI S+VF 
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197
            RFDY+D+ FL+L+      F+  ++   Q+   F  ++   PG   +  K +     +I
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257
            +KV+ +Q +LD N+P+DFID FLI M++E+ N  +EF ++NL+ +  +LF+AGTET ST
Sbjct: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304

Query: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364

Query: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFLD  G FKKSD 
Sbjct: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424

Query: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +       ++P +Y 
Sbjct: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484

Query: 438 MSFLP 442
           + F+P
Sbjct: 485 ICFIP 489


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  394 bits (1011), Expect = e-109
 Identities = 203/485 (41%), Positives = 289/485 (59%), Gaps = 50/485 (10%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           VALL     ++L+S+W+Q  S   LPPGP PLP IGN  QL  ++I  S  +++Q     
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 64  ---------------------------------------------GVAFSNGERAKQLLR 78
                                                        G+ F+NG   K + R
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRR 127

Query: 79  FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 138
           F++ TLR++G+GK+G E RIQ E+ FL+EA+R T G   DPTF +     NVI+ I+F  
Sbjct: 128 FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRK 187

Query: 139 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 198
            FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  K +  ++++++
Sbjct: 188 HFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS 247

Query: 199 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 258
           ++V+ + ++LDPN P+D  D  L+ M++E+ +    + +  + ++  +LF AGTET STT
Sbjct: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTT 307

Query: 259 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 318
           LRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P +
Sbjct: 308 LRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN 367

Query: 319 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 378
           L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFL++ G+FK SD F
Sbjct: 368 LPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYF 427

Query: 379 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 438
            PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+ F  IP  Y +
Sbjct: 428 KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKL 487

Query: 439 SFLPR 443
             +PR
Sbjct: 488 CVIPR 492


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  374 bits (959), Expect = e-103
 Identities = 199/487 (40%), Positives = 287/487 (58%), Gaps = 54/487 (11%)

Query: 10  ALLACLTVMVLMSV-WQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           ALL  L +++L+++     ++RG LPPGPTPLP +GN LQL    +   +M++S+     
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67

Query: 64  -----------------------------------------------GVAFSNGERAKQL 76
                                                          GV FSNGER +QL
Sbjct: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

Query: 77  LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 136
            +F +  LRD G+GKR  EE IQ E+  L+E  + T G   DP+  L++  SNV+ S++F
Sbjct: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187

Query: 137 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 196
           G RF YEDKEF +++    G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247

Query: 197 IAKKVEHNQRTLDPNSP-QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 255
             ++V+ +Q  LD + P +D +D+FL+ M +EE+NP TEF  KN++M+ + L  AGT TV
Sbjct: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307

Query: 256 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 315
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DRT++PY +AV+HE QR   ++
Sbjct: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367

Query: 316 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 375
           PM + R + + T+FR + LP+GTEVFP+LGS+L DP+ F +P++FNP  FLD  G+F+K 
Sbjct: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427

Query: 376 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN 435
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P       IP  
Sbjct: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487

Query: 436 YTMSFLP 442
           + +   P
Sbjct: 488 FQLQVRP 494


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  352 bits (904), Expect = 3e-97
 Identities = 195/485 (40%), Positives = 268/485 (55%), Gaps = 110/485 (22%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+   S+     
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 64  ----------------------------------------------GVAFSNGERAKQLL 77
                                                         G+ FSNG+R K++ 
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214

Query: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257
                                        E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245

Query: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305

Query: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365

Query: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425

Query: 438 MSFLP 442
           + F+P
Sbjct: 426 LCFIP 430


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  330 bits (845), Expect = 2e-90
 Identities = 178/459 (38%), Positives = 265/459 (57%), Gaps = 52/459 (11%)

Query: 11  LLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEH----------------- 53
           LL      +L + + +R+     PPGP  LPF+GN+  ++ E                  
Sbjct: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80

Query: 54  ----------------ICDSIMKVSQ------------------GVAFSNGERAKQLLRF 79
                           I ++++ + Q                  G+  S+G+  K+  RF
Sbjct: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140

Query: 80  AIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDR 139
            +  LR+FG+GK+ +EERIQEE+  L EAI+  +G   DP F ++  VSN+I SI FG+R
Sbjct: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

Query: 140 FDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAK 199
           F+Y+D  F  LL ++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260

Query: 200 KVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTL 259
            ++ +++  +P   +DFID++L  M +   NP + F+ +NL+ STL+LF AGTET STTL
Sbjct: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 260 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSL 319
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 320 ARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFV 379
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL++ GQFKK +AF+
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN-GQFKKREAFM 439

Query: 380 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK 418
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  268 bits (684), Expect = 1e-71
 Identities = 167/498 (33%), Positives = 262/498 (52%), Gaps = 68/498 (13%)

Query: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQL---NTEHICDSIMK-- 60
           LV L   + + +L+     R+ R   + PPGP PLP +GN L +   NT +  D + +  
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 61  --------------VSQGVA------FSNGERA--------------------------- 73
                         V  G+A       ++GE                             
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125

Query: 74  ---KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNV 130
              ++  RF+++TLR+ G+GK+ +E+ + EE+  L  A  +  G    P   L + VSNV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185

Query: 131 ISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS--VMKHLPGPQQQAFK 188
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242

Query: 189 LLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 247
             +     + + +  ++ T DP   P+D  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302

Query: 248 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 307
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+  MPY  AVIHE
Sbjct: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362

Query: 308 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 367
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFLD
Sbjct: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422

Query: 368 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 427
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S   P        H 
Sbjct: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHG 479

Query: 428 VFATI--PRNYTMSFLPR 443
           VFA +  P  Y +  +PR
Sbjct: 480 VFAFLVTPSPYELCAVPR 497


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  264 bits (675), Expect = 1e-70
 Identities = 153/388 (39%), Positives = 230/388 (59%), Gaps = 7/388 (1%)

Query: 57  SIMKVSQGVAFSN-GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGA 115
           SI+   +GV F++ G   +Q  +F+ +TLR FG+GK  +E +I EE  + ++A    HG 
Sbjct: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHGE 215

Query: 116 N-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS 174
           +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +   
Sbjct: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-CP 274

Query: 175 VMKHLP-GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKN-PN 232
            + +LP GP ++  ++ + +  F+ K ++ +Q +LD  +PQDFID +L+HM+EE KN  N
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334

Query: 233 TEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 292
           + F  + L     +LFIAGT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P  
Sbjct: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394

Query: 293 EDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPS 352
            D+ +MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP+
Sbjct: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454

Query: 353 FFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 412
            +  P+DF P  FLDD+GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F   
Sbjct: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514

Query: 413 -SSQSPKDIDVSPKHVVFATIPRNYTMS 439
               S K +      +  A  P N T+S
Sbjct: 515 LPEDSKKPLLTGRFGLTLAPHPFNITIS 542



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 17/37 (45%), Positives = 23/37 (62%)

Query: 10 ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNY 46
          ALL C  V +L   W +R+    +PPGPTP P +GN+
Sbjct: 36 ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNF 72


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  251 bits (640), Expect = 1e-66
 Identities = 123/334 (36%), Positives = 200/334 (59%)

Query: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137
           R A+ + R FG G++  E +I EE+ F  +AI +  G   D    ++  VSN+ + I+FG
Sbjct: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197

Query: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197
           +RF YED +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + DF+
Sbjct: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257

Query: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257
           ++ +E       P  PQ F+D++L  M + + +P++ F  +NL+ S   L IAGTET + 
Sbjct: 258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTN 317

Query: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317
            LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++P+
Sbjct: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377

Query: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377
            +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FLD  G F K +A
Sbjct: 378 GIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEA 437

Query: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 411
            VPFS+G+R+C GE LARME+FLFFT ++Q F L
Sbjct: 438 LVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 1/40 (2%)

Query: 10 ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQL 49
          AL   L  + +  + +QR+  G  PPGP  LPFIGN   L
Sbjct: 17 ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSL 55


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  248 bits (633), Expect = 8e-66
 Identities = 154/452 (34%), Positives = 242/452 (53%), Gaps = 27/452 (5%)

Query: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHI--CDSIMKVSQ 63
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ ++   C   ++   
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 64  GVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRS-------THGAN 116
           G  FS      QL    +  L      +  +    ++ +      I         + G  
Sbjct: 66  GDVFS-----LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRP 120

Query: 117 IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSV- 175
             P   L + VSNVI+S+  G RF+Y+D  FL LL +     +     +G L E+ ++V 
Sbjct: 121 FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVP 177

Query: 176 -MKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNT 233
            + H+P    +  +  +     + + +  ++ T DP   P+D  ++FL  M++ + NP +
Sbjct: 178 VLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPES 237

Query: 234 EFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFE 293
            F  +NL +   +LF AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  
Sbjct: 238 SFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG 297

Query: 294 DRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSF 353
           D+  MPY  AVIHE+QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + 
Sbjct: 298 DQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV 357

Query: 354 FSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS 413
           +  P  F+P+HFLD +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S
Sbjct: 358 WEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---S 414

Query: 414 SQSPKDIDVSPKHVVFATI--PRNYTMSFLPR 443
              P        H VFA +  P  Y +  +PR
Sbjct: 415 FSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 446


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  229 bits (585), Expect = 3e-60
 Identities = 155/497 (31%), Positives = 238/497 (47%), Gaps = 69/497 (13%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKS-RGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ- 63
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L       S+M++S+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 64  --------------------------------------------------GVAFSNGERA 73
                                                             G+ FS+G R 
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 74  KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISS 133
           +   +F +  L   GVG+  + ++I +E   L   +    G    P   L    SN+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 134 IVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFKL 189
           ++FG RFDY D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236

Query: 190 LQGLEDFIAKKVEHNQRTLDPNSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLF 248
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N +  TL++ 
Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294

Query: 249 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 308
           +AGTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354

Query: 309 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 368
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFLD 
Sbjct: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413

Query: 369 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 426
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473

Query: 427 VVFATIPRNYTMSFLPR 443
             F   PR   +  +PR
Sbjct: 474 -AFTMRPRAQALCAVPR 489


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  188 bits (477), Expect = 1e-47
 Identities = 135/490 (27%), Positives = 225/490 (45%), Gaps = 70/490 (14%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIM 59
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L    H+  S M
Sbjct: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRM 66

Query: 60  KVSQG------------VAFSNGERAKQLL------------------------------ 77
               G            V  S  +  +Q L                              
Sbjct: 67  SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD 126

Query: 78  ---------RFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NIDP 119
                    R A   L+ F +           +EE + +E+  LI  ++       + +P
Sbjct: 127 SGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNP 186

Query: 120 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHL 179
             ++  +V+NVI +I FG R+D+  +E LSL+++     +   +        F  ++++L
Sbjct: 187 YRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYL 243

Query: 180 PGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEE--KNPNTEFY 236
           P P   AFK L +    F+ K V+ + +T +    +D  DS + H QE++  +N N +  
Sbjct: 244 PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLS 303

Query: 237 LKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRT 296
            + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR+
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 297 KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSN 356
            +PYMEA I E  R    +P ++     +DT  + F++PKG  VF     +  D   + N
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 357 PQDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 414
           P +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q       
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 415 QSPKDIDVSP 424
              K +D++P
Sbjct: 484 LGVK-VDMTP 492


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  161 bits (408), Expect = 1e-39
 Identities = 97/337 (28%), Positives = 168/337 (49%), Gaps = 10/337 (2%)

Query: 94  IEERIQEESGFLIEAIRSTHGA--NIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL 151
           +EE + +E+  LI  ++       + DP   +  +V+NVI ++ FG  F     E LSL+
Sbjct: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220

Query: 152 SMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLL-QGLEDFIAKKVEHNQRTLDP 210
                  +F  T++      F  ++++LP P  Q FK   Q    F+ K V+ + +  D 
Sbjct: 221 K---NTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277

Query: 211 NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHP 270
           NS +D   +   H ++  +        + ++    ++F AG +TV+T + +  + L+  P
Sbjct: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337

Query: 271 EVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFR 330
           E++ K+ +E+D VIG+ R+P+  DR ++PY+EA I E  R    +P ++     +DT   
Sbjct: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397

Query: 331 DFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKG---QFKKSDAFVPFSIGKRN 387
            F++PK   VF     V  DP  + +P +F P+ FL   G       S+  + F +GKR 
Sbjct: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457

Query: 388 CFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 424
           C GE LA+ E+FLF   ++Q          K +D++P
Sbjct: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 493


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  160 bits (405), Expect = 2e-39
 Identities = 129/484 (26%), Positives = 228/484 (47%), Gaps = 76/484 (15%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGN-------------------- 45
           LLL+++LA + V   + + Q+R+     PPGP   P IGN                    
Sbjct: 24  LLLLSVLATVHVGQRL-LRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYG 82

Query: 46  -----------YLQLNTEHICDSIMKVSQGVAFSN---------------------GERA 73
                       + LN E      + V QG AF++                      E  
Sbjct: 83  DVFQIRLGSCPIVVLNGERAIHQAL-VQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141

Query: 74  KQLLRFAIATLRDFGV----GKRGIEERIQEESGFLIEAI--RSTHGANIDPTFFLSRTV 127
           K   R A + +R+F       ++ +E  +  E+  L+  +   S  GA +DP       V
Sbjct: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201

Query: 128 SNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF 187
           +NV+S++ FG R+ ++D EF  LLS      +  +   G L ++    +++ P P +  F
Sbjct: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTVF 258

Query: 188 K----LLQGLEDFIAKKVEHNQRTLDPNS-PQDFIDSFLIHMQEEEKNPN----TEFYLK 238
           +    L +   +FI  K   +  +L P + P+D +D+F++  +++    +        L+
Sbjct: 259 REFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE 318

Query: 239 NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKM 298
           N+  +  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  +
Sbjct: 319 NVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNL 378

Query: 299 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 358
           PY+ A ++E  RF   +P+++      +T    + +PK T VF    SV  DP  + NP+
Sbjct: 379 PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPE 438

Query: 359 DFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKSS 414
           +F+P  FLD  G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   +
Sbjct: 439 NFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN 498

Query: 415 QSPK 418
           +  K
Sbjct: 499 EPAK 502


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  140 bits (353), Expect = 2e-33
 Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 13/360 (3%)

Query: 63  QGVAFSNGERAKQL-LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTF 121
           +G+AF++     QL  R A+AT   F  G + +E+ I +E   L + + + +G +ID +F
Sbjct: 110 KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169

Query: 122 FLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPG 181
            +   V+NVIS I F   +   D E   + +   GI    + S   L ++    +K  P 
Sbjct: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPN 226

Query: 182 PQQQAFKL-LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFL-IHMQEEEKNP----NTEF 235
              +  K  ++   D + K +E+ +     +S  + +D+ +   M  +  N     ++E 
Sbjct: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286

Query: 236 YLKNLMMSTL-NLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 294
              N +++T+ ++F AG ET ++ +++    L+ +P+V+ K++EEID+ +G +R P   D
Sbjct: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346

Query: 295 RTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFF 354
           R ++  +EA I E+ R   V PM +  +   D+   +F + KGTEV   L ++  +   +
Sbjct: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406

Query: 355 SNPQDFNPQHFLDDKGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 412
             P  F P+ FL+  G      S +++PF  G R+C GE LAR ELFL    ++Q F L+
Sbjct: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  116 bits (290), Expect = 5e-26
 Identities = 81/327 (24%), Positives = 158/327 (48%), Gaps = 17/327 (5%)

Query: 94  IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 153
           +E+  QE      E +R+  G  +      S    ++I  + FGD+   +D    +    
Sbjct: 110 VEQLTQE----FCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 164

Query: 154 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNS 212
           +  + +  S  + Q+ ++    ++  P P  +  K  ++  +  +  ++  ++ +L    
Sbjct: 165 IQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 223

Query: 213 PQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPE 271
            +D +D  L  + +      +   L+ ++ M+ ++L I GTET + TL +  + L+ HPE
Sbjct: 224 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 283

Query: 272 VEAKVHEEIDRVIG----KNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDT 327
           ++ ++ EE+D  +G     +R P ++DR ++P + A I E+ R   V+P++L  R  + +
Sbjct: 284 IQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPS 342

Query: 328 KFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRN 387
               + +P+GT + P L     D + +  P +F P  FL+      K+   + F  G R 
Sbjct: 343 SISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCGARV 398

Query: 388 CFGEGLARMELFLFFTTVMQNFRLKSS 414
           C GE LAR+ELF+  T ++Q F L  S
Sbjct: 399 CLGEPLARLELFVVLTRLLQAFTLLPS 425


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  116 bits (290), Expect = 5e-26
 Identities = 81/327 (24%), Positives = 158/327 (48%), Gaps = 17/327 (5%)

Query: 94  IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 153
           +E+  QE      E +R+  G  +      S    ++I  + FGD+   +D    +    
Sbjct: 140 VEQLTQE----FCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 194

Query: 154 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNS 212
           +  + +  S  + Q+ ++    ++  P P  +  K  ++  +  +  ++  ++ +L    
Sbjct: 195 IQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 253

Query: 213 PQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPE 271
            +D +D  L  + +      +   L+ ++ M+ ++L I GTET + TL +  + L+ HPE
Sbjct: 254 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 313

Query: 272 VEAKVHEEIDRVIG----KNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDT 327
           ++ ++ EE+D  +G     +R P ++DR ++P + A I E+ R   V+P++L  R  + +
Sbjct: 314 IQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPS 372

Query: 328 KFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRN 387
               + +P+GT + P L     D + +  P +F P  FL+      K+   + F  G R 
Sbjct: 373 SISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCGARV 428

Query: 388 CFGEGLARMELFLFFTTVMQNFRLKSS 414
           C GE LAR+ELF+  T ++Q F L  S
Sbjct: 429 CLGEPLARLELFVVLTRLLQAFTLLPS 455


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  111 bits (277), Expect = 2e-24
 Identities = 65/211 (30%), Positives = 114/211 (54%), Gaps = 6/211 (2%)

Query: 211 NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHP 270
           N  + F+D  L+ + ++E N  +    +++          G +T +  + +   LL  +P
Sbjct: 294 NKRRAFLD-LLLSVTDDEGNRLSH---EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNP 349

Query: 271 EVEAKVHEEIDRVIGKNRQPK-FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF 329
           EV+ KV  E+D V GK+ +P   ED  K+ Y+E VI E  R    +P+  AR V +D + 
Sbjct: 350 EVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEV 408

Query: 330 RDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCF 389
             + + KGTE   +  ++ RDP +F NP++F P+ F  +  Q +   A+VPFS G RNC 
Sbjct: 409 AGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCI 468

Query: 390 GEGLARMELFLFFTTVMQNFRLKSSQSPKDI 420
           G+  A ME     + ++++F ++S+Q  +++
Sbjct: 469 GQKFAVMEEKTILSCILRHFWIESNQKREEL 499


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  102 bits (255), Expect = 5e-22
 Identities = 73/257 (28%), Positives = 125/257 (48%), Gaps = 15/257 (5%)

Query: 195 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFY--LKNLMMSTLNLFI--A 250
           +F++K V   +++   +  +  +D FL  M + + +  TE +  L +L ++  ++    A
Sbjct: 247 NFLSKSVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305

Query: 251 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQR 310
           G ET S+ L +    L  HP+V+ K+ +EID V+     P ++   +M Y++ V++E  R
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 311 FGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKG 370
              V  + L R  KKD +    F+PKG+ V     ++  DP +++ P++F P+ F   K 
Sbjct: 366 LFPV-AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 424

Query: 371 QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL---KSSQSPKDIDVS---- 423
                  + PF  G RNC G   A M + L    V+QNF     K +Q P  +D      
Sbjct: 425 SIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483

Query: 424 -PKHVVFATIPRNYTMS 439
             K +V     R+ T+S
Sbjct: 484 PEKPIVLKVDSRDGTLS 500


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  102 bits (253), Expect = 9e-22
 Identities = 66/222 (29%), Positives = 107/222 (48%), Gaps = 6/222 (2%)

Query: 195 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK----NLMMSTLNLFIA 250
           +F+ K V+  + +   ++ +  +D FL  M + + +  TE +       L+  ++    A
Sbjct: 247 NFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305

Query: 251 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQR 310
           G ET S+ L +    L  HP+V+ K+ EEID V+     P ++   +M Y++ V++E  R
Sbjct: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 365

Query: 311 FGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKG 370
               I M L R  KKD +    F+PKG  V     ++ RDP +++ P+ F P+ F     
Sbjct: 366 LFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424

Query: 371 QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 412
                  + PF  G RNC G   A M + L    V+QNF  K
Sbjct: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 11/13 (84%), Positives = 12/13 (92%)

Query: 35 PGPTPLPFIGNYL 47
          PGPTPLPF+GN L
Sbjct: 39 PGPTPLPFLGNIL 51


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  102 bits (253), Expect = 9e-22
 Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 17/276 (6%)

Query: 176 MKHL-PGPQQQAFKLLQGLEDFIAKKVEHNQRTL---DPNSPQDFIDS--FLIHMQEEEK 229
           ++HL PGP  +  +    +  F  + VE  +      +   P+  ++S   L H    E+
Sbjct: 242 LRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE 301

Query: 230 NPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVI--GKN 287
            P      ++++ +   L +AG +TVS TL +    L +HPEV+  +H EI   +  G +
Sbjct: 302 LP-----AQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSS 356

Query: 288 RQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSV 347
             P     +++P ++AV+ E+ R   V+P + +R   KD    D+ +PK T V     + 
Sbjct: 357 AYPSATVLSQLPLLKAVVKEVLRLYPVVPGN-SRVPDKDIHVGDYIIPKNTLVTLCHYAT 415

Query: 348 LRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ 407
            RDP+ F  P  F P  +L + G      A +PF  GKR+C G  LA +EL +    ++ 
Sbjct: 416 SRDPAQFPEPNSFRPARWLGE-GPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILT 474

Query: 408 NFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR 443
           +F ++    P    V PK        R+  + FL R
Sbjct: 475 HFEVQ--PEPGAAPVRPKTRTVLVPERSINLQFLDR 508


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 1/198 (0%)

Query: 215 DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEA 274
           DF+   +     ++   +       LM  ++    AG ET S+ L +    L  HP+V+ 
Sbjct: 270 DFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQ 329

Query: 275 KVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFL 334
           KV +EID V+     P ++   ++ Y++ V++E  R   V  M L R  KKD +    F+
Sbjct: 330 KVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPV-AMRLERVCKKDVEINGMFI 388

Query: 335 PKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLA 394
           PKG  V      +  DP +++ P+ F P+ F            + PF  G RNC G   A
Sbjct: 389 PKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448

Query: 395 RMELFLFFTTVMQNFRLK 412
            + + L    V+QNF  K
Sbjct: 449 LVNMKLALVRVLQNFSFK 466



 Score = 29.6 bits (65), Expect = 5.7
 Identities = 11/13 (84%), Positives = 12/13 (92%)

Query: 35 PGPTPLPFIGNYL 47
          PGPTPLPF+GN L
Sbjct: 39 PGPTPLPFLGNAL 51


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,072,185
Number of Sequences: 37866
Number of extensions: 692321
Number of successful extensions: 1943
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1766
Number of HSP's gapped (non-prelim): 111
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.