Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 150456473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
(831 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150456473 janus kinase and microtubule interacting protein 1 ... 1595 0.0
gi|21389505 janus kinase and microtubule interacting protein 1 i... 1155 0.0
gi|45237195 Janus kinase and microtubule interacting protein 2 [... 1016 0.0
gi|157502225 Janus kinase and microtubule interacting protein 3 ... 1004 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 122 1e-27
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 122 1e-27
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 122 1e-27
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 122 1e-27
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 122 1e-27
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 122 1e-27
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 122 1e-27
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 122 1e-27
gi|148746195 trichohyalin [Homo sapiens] 117 4e-26
gi|28416946 myosin 18A isoform a [Homo sapiens] 113 8e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 106 1e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 105 1e-22
gi|42794779 myosin 18A isoform b [Homo sapiens] 103 5e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 102 1e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 102 1e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 102 1e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 102 1e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 102 1e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 102 2e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 9e-21
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 98 3e-20
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 96 1e-19
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 96 1e-19
gi|71061468 centromere protein E [Homo sapiens] 96 1e-19
gi|16262452 cingulin [Homo sapiens] 96 2e-19
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 95 3e-19
>gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
Length = 831
Score = 1595 bits (4131), Expect = 0.0
Identities = 831/831 (100%), Positives = 831/831 (100%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL
Sbjct: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA
Sbjct: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK
Sbjct: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
Query: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV
Sbjct: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
Query: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL
Sbjct: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL
Sbjct: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
Query: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA
Sbjct: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
Query: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE
Sbjct: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
Query: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE
Sbjct: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE
Sbjct: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQAL 720
QVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQAL
Sbjct: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQAL 720
Query: 721 DQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQI 780
DQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQI
Sbjct: 721 DQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQI 780
Query: 781 LRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLFLFLFFSLAFILWP 831
LRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLFLFLFFSLAFILWP
Sbjct: 781 LRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLFLFLFFSLAFILWP 831
>gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
Length = 626
Score = 1155 bits (2987), Expect = 0.0
Identities = 603/605 (99%), Positives = 604/605 (99%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL
Sbjct: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA
Sbjct: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK
Sbjct: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
Query: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV
Sbjct: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
Query: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL
Sbjct: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL
Sbjct: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
Query: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA
Sbjct: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
Query: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE
Sbjct: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
Query: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE
Sbjct: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
Query: 601 LEERE 605
LE R+
Sbjct: 601 LEVRD 605
Score = 35.4 bits (80), Expect = 0.22
Identities = 40/149 (26%), Positives = 66/149 (44%), Gaps = 31/149 (20%)
Query: 682 EGTEAALTQKMLDLEKEKDLFSR-----QKGYLEEELDYRKQALDQAYLK---------- 726
E A LT ++ ++EK + Q+ LE E + R+ + LK
Sbjct: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
Query: 727 IQDLEATLYTALQQEPGRRAGEALSEGQREDLQA--------AVEKVRRQILRQSRE--- 775
+Q L L +QE R A + EG+ + LQA A +KV+ +L ++RE
Sbjct: 84 LQALREGLIRQHEQEAARTA--KIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
Query: 776 --FDSQILRERMELLQQAQQRIRELEDKL 802
FD + LR + E+L+ R ++ E+ L
Sbjct: 142 RAFDGERLRLQQEILELKAAR-KQAEEAL 169
>gi|45237195 Janus kinase and microtubule interacting protein 2
[Homo sapiens]
Length = 810
Score = 1016 bits (2626), Expect = 0.0
Identities = 532/816 (65%), Positives = 662/816 (81%), Gaps = 13/816 (1%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLERE 59
MSKKGR+KGEKPE A+Q ANE+LR KLT IQIE QEKSKV KL RE+ QEAK RE
Sbjct: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
Query: 60 QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNV 119
EQR+HT ++ELKAKLHEEK KELQA+RE LI+QHEQE +RT K+++GE+QRL++ L
Sbjct: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
Query: 120 LRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
LRDG++DKV+TAL EAREEAR+ FD ERL+L QEI +LK A+KQ +EALSN +QADK K
Sbjct: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
Query: 180 AADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ 239
A DLR+ +Q+HQ+ + +IK E ERDIRRLMDEIK KDR+I +LEKEL Q G QKL LQ
Sbjct: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
Query: 240 KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNS 299
KEALDEQL VKEAE + SSPKRE+P GD +H D+RR Q +IAELN+
Sbjct: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGD-------GSEHCSSPDLRRNQKRIAELNA 293
Query: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
IRKLEDRNTLL DERNELLKR RETE Q KPL+E+NK + K+N++L+ S+QRMEEK+K
Sbjct: 294 TIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKA 353
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
+T+EN EM+EK+++ LK+ SLNDL +EQE EFL+LQV+EQQ++ID+L+ +RE+L
Sbjct: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
Query: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
+R ++HR +S KP K+ V++ F G+DE+S+DSET S S+ RTDRTPATP++DLD++
Sbjct: 414 IRRRKHR-RSSKPIKRPVLDPFIGYDEDSMDSETSSMASF---RTDRTPATPDDDLDESL 469
Query: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
A EE++LRF QLT+EYQALQRAYALLQEQ GG +DAEREA+ +EQLQA++LR +AKIEDL
Sbjct: 470 AAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDL 529
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVL 599
E L +KGQDS WVE+KQL I+ NQ+LLEKI + E E ++L+ E+QDA+DQNELLEFR L
Sbjct: 530 EATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNL 589
Query: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNE 659
ELEERERRSP FNLQI F + SALQ++C +EGVKDVN+ +L+K+LDILGDNGNLRNE
Sbjct: 590 ELEERERRSPPFNLQIHPFSDG-VSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNE 648
Query: 660 EQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
EQVAIIQA TVL+L EKW++QIEG EAAL QKM++LE + + F + KGYLEEELDYRKQA
Sbjct: 649 EQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQA 708
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
LDQAY++IQ+LEATLY ALQQE + GE LSE Q+E+L+ AVEK+RRQ+LR+SRE+D Q
Sbjct: 709 LDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQ 768
Query: 780 ILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
IL+ERMELLQQA QRIR+LEDK + QKR +K+LEEK
Sbjct: 769 ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
>gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
Length = 844
Score = 1004 bits (2595), Expect = 0.0
Identities = 528/848 (62%), Positives = 667/848 (78%), Gaps = 23/848 (2%)
Query: 1 MSKKG---RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKL 56
MSK+G R+KG+K E A+Q ANE+LRAKLT IQIE QQEKSKV K+ RE+ QE +
Sbjct: 1 MSKRGMSSRAKGDKAEALA-ALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
Query: 57 EREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
RE EQ + ++ELK KLHEEK KELQA+RE L+RQHE E R KIK+ E QRLQA
Sbjct: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
L+ LRDG +KVKT LL+EA+EEA++ F+ E++++QQEI ELK A++Q EEAL+ +QAD
Sbjct: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKL 236
K KAA++R+ Y HQ+E+ RIK+ECER+IRRLM+EIK KDR + LE+ELGVQAG Q+L
Sbjct: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
Query: 237 LLQKEALDEQLVQVKEAERHHSSPKRELP--PGIGDMVELMGVQDQHMDERDVRRFQLKI 294
LQKEALDEQL QV+EA+RH SP+RELP G GD + G +Q +DE+D RRFQLKI
Sbjct: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
AEL+++IRKLEDRN LL++ERNELLKR RE E Q KPL++KNKR+++KNEDL +++RME
Sbjct: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
Query: 355 EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLS- 413
K+K +T+EN+EM+++ ++R +SLNDL ++DE+E++FL+LQ++EQQ++ID+LS
Sbjct: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
Query: 414 -----------LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
LER++LLR ++ R K K PK VVETFFG+DEE+ S SY TD
Sbjct: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
Query: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
RTD+TP TP++DL++ A+EE +LRF QLT EYQALQRAYALLQEQVGGTLDAERE +TR
Sbjct: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
EQLQA++ R QA+IEDLEK L E+GQD KW+EEKQ L R NQ+L+EKI ++E EE +L++
Sbjct: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
Query: 583 EMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSE 642
E+QDA+DQNELLEFR+LELEERER+SPA + T F + S LQ++C EGV D+ V+E
Sbjct: 597 EVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDG-KSPLQVYCEAEGVTDIVVAE 655
Query: 643 LMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLF 702
LMKKLDILGDN NL NEEQV +IQA TVL L EKWL+QIE TEAAL +KM+DLE EK+LF
Sbjct: 656 LMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELF 715
Query: 703 SRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAV 762
S+QKGYL+EELDYRKQALDQA I +LEA LY ALQQE G + E LSE +RE L+ AV
Sbjct: 716 SKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAV 775
Query: 763 EKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLFLFLF 822
E+ +RQ++ + RE D+QILRERMELLQ AQQRI+ELE+++E QKR +KELEEKFLFLFLF
Sbjct: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLF 835
Query: 823 FSLAFILW 830
FSLAFILW
Sbjct: 836 FSLAFILW 843
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1885 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 2000 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2048
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2096
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2148
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2209 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2262 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2307
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2365
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2366 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2418 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2471
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2526 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1415
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1416 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1467 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1520
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1521 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1574
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1688
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1737
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1738 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1783
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1784 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1842 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1896
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1897 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1948
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 2009 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 811 ELE 813
E E
Sbjct: 2062 EQE 2064
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2031
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2192 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2302
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2363 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2420
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2540 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2599 QLLEEQHRAALAHSE----EVTASQVAATKTL 2626
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2101
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2102 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2204
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2445 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2504 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2554
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2608
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2609 L---AHSEEV 2615
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1173
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1227
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1228 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1268
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1324
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1325 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1361
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1362 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1469
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1470 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1507
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1562
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1798
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEE 1822
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2460
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2517
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2518 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2566
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2626 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2683 ARREDVRHY 2691
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2510 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2622
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2679
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2680 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2727
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1224
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1392
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1393 LQQRMQ 1398
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1889 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1943
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 2004 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2052
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2100
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2152
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2213 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2265
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2266 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2311
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2369
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2370 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2422 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2475
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2476 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2530 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1419
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1420 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1471 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1524
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1525 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1578
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1638
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1692
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1741
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1742 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1787
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1788 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1846 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1900
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1901 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1952
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 2013 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 811 ELE 813
E E
Sbjct: 2066 EQE 2068
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2035
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2036 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2196 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2306
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2367 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2424
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2483
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2544 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2603 QLLEEQHRAALAHSE----EVTASQVAATKTL 2630
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2105
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2106 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2208
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2449 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2508 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2558
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2559 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2612
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2613 L---AHSEEV 2619
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1177
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1178 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1231
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1232 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1272
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1328
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1329 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1365
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1366 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1473
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1474 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1511
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1512 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1566
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1802
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEE 1826
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2464
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2521
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2522 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2570
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2630 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2687 ARREDVRHY 2695
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2514 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2626
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2683
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2684 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2731
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1110
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1170
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1171 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1228
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1288
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1396
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1397 LQQRMQ 1402
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1885 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 2000 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2048
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2096
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2148
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2209 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2262 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2307
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2365
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2366 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2418 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2471
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2526 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1415
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1416 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1467 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1520
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1521 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1574
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1688
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1737
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1738 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1783
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1784 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1842 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1896
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1897 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1948
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 2009 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 811 ELE 813
E E
Sbjct: 2062 EQE 2064
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2031
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2192 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2302
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2363 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2420
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2540 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2599 QLLEEQHRAALAHSE----EVTASQVAATKTL 2626
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2101
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2102 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2204
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2445 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2504 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2554
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2608
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2609 L---AHSEEV 2615
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1173
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1227
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1228 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1268
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1324
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1325 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1361
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1362 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1469
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1470 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1507
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1562
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1798
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEE 1822
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2460
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2517
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2518 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2566
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2626 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2683 ARREDVRHY 2691
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2510 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2622
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2679
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2680 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2727
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1224
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1392
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1393 LQQRMQ 1398
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1853 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1907
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 1968 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2016
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2064
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2116
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2177 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2229
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2230 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2275
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2333
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2334 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2386 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2439
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2440 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2494 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1383
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1384 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1435 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1488
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1489 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1542
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1656
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1705
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1706 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1751
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1752 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1810 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1864
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1865 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1916
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 1977 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 811 ELE 813
E E
Sbjct: 2030 EQE 2032
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 1999
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2000 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2160 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2270
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2331 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2388
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2447
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2508 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2567 QLLEEQHRAALAHSE----EVTASQVAATKTL 2594
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2069
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2070 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2172
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2413 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2472 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2522
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2523 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2576
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2577 L---AHSEEV 2583
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1141
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1142 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1195
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1196 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1236
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1292
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1293 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1329
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1330 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1437
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1438 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1475
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1476 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1530
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1766
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEE 1790
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2428
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2485
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2486 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2534
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2594 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2651 ARREDVRHY 2659
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2478 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2590
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2647
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2648 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2695
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1074
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1134
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1135 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1192
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1252
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1360
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1361 LQQRMQ 1366
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 2022 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 2076
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 2137 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2185
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2233
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2285
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2346 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2398
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2399 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2444
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2502
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2503 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2555 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2608
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2609 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2663 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1552
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1553 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1604 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1657
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1658 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1711
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1771
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1825
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1874
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1875 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1920
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1921 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1979 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 2033
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 2034 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 2085
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 2146 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 811 ELE 813
E E
Sbjct: 2199 EQE 2201
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2168
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2169 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2329 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2439
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2500 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2557
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2616
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2677 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2736 QLLEEQHRAALAHSE----EVTASQVAATKTL 2763
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2238
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2239 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2341
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2582 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2641 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2691
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2692 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2745
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2746 L---AHSEEV 2752
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1310
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1311 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1364
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1365 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1405
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1461
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1462 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1498
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1499 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1606
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1607 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1644
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1645 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1699
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1935
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEE 1959
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2597
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2654
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2655 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2703
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2763 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2820 ARREDVRHY 2828
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2647 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2759
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2816
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2817 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2864
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1243
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1303
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1304 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1361
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1421
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1529
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1530 LQQRMQ 1535
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1863 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1917
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 1978 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2026
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2074
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2126
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2187 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2239
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2240 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2285
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2286 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2343
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2344 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2396 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2449
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2450 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2504 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1393
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1394 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1445 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1498
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1499 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1552
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1612
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1666
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1715
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1716 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1761
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1762 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1820 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1874
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1875 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1926
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 1987 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 811 ELE 813
E E
Sbjct: 2040 EQE 2042
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2009
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2010 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2169
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2170 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2280
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2341 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2398
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2457
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2518 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2577 QLLEEQHRAALAHSE----EVTASQVAATKTL 2604
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2079
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2080 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2182
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2423 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2482 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2532
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2533 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2586
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2587 L---AHSEEV 2593
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1151
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1152 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1205
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1206 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1246
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1302
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1303 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1339
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1340 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1447
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1448 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1485
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1486 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1540
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1776
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEE 1800
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2438
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2495
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2496 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2544
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2604 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2661 ARREDVRHY 2669
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2488 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2600
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2657
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2658 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2705
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1084
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1202
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1262
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1370
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1371 LQQRMQ 1376
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1871 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1925
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 1986 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2034
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2082
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2134
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2195 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2247
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2248 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2293
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2294 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2351
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2352 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2404 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2457
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2458 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2512 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1401
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1402 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1453 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1506
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1507 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1560
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1620
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1674
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1723
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1724 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1769
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1770 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1828 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1882
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1883 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1934
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 1995 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 811 ELE 813
E E
Sbjct: 2048 EQE 2050
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2017
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2018 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2177
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2178 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2288
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2349 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2406
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2465
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2526 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2585 QLLEEQHRAALAHSE----EVTASQVAATKTL 2612
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2087
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2088 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2190
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2431 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2490 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2540
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2541 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2594
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2595 L---AHSEEV 2601
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1159
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1160 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1213
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1214 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1254
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1310
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1311 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1347
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1348 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1455
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1456 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1493
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1494 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1548
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1784
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEE 1808
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2446
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2503
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2504 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2552
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2612 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2669 ARREDVRHY 2677
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2496 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2608
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2665
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2666 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2713
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1092
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1152
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1153 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1210
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1270
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1378
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1379 LQQRMQ 1384
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 122 bits (307), Expect = 1e-27
Identities = 179/838 (21%), Positives = 357/838 (42%), Gaps = 112/838 (13%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+H A I E A+L + EL+ ++GL+ ++ R + E E+ L+A+
Sbjct: 1912 AQHKADIEERLAQLRKASDSELER-QKGLV----EDTLRQRRQVEEEILALKASFEKAAA 1966
Query: 123 GAAD-KVKTALLTEAREEARRAFDGERL---RLQQEILELKAARKQAEEALSNCMQADKT 178
G A+ +++ + E+ R+ + L R +Q E + R++AEE + + A++
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 179 KAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
A +AA + EV R+K + E + RRL + + + L L +E QK L
Sbjct: 2027 AARQRKAALE----EVERLKAKVE-EARRLRERAEQESARQLQLAQEAA------QKRLQ 2075
Query: 239 QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN 298
+E VQ KE E + + + V DQ E + R + AE
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLRGEAEAARRAAEEAEEA 2123
Query: 299 SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK 358
V + E + E E LK+S E + Q + + +K + +E +
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--------QEAAR 2175
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLRLQVLEQQHVIDDLSLE 415
E +++K +A A +++H + +L + EQE+ LRLQ+ E H + L E
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
+RL + + V E F V E LS+ + +R ++D
Sbjct: 2236 LQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKARIEAENRALILRDKDN 2288
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK 535
+EEA+ + Q+ E L A A+ AR R+ + DL + +A
Sbjct: 2289 TQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAARLRQLAEEDLAQQRAL 2334
Query: 536 IEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELL 594
E + K ++ Q++ ++ + L++ ++L E+ RL+ ++ Q+ ++ + +
Sbjct: 2335 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ-- 2392
Query: 595 EFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN- 653
R LE E + + L+++ E + + + + K+ + +G+
Sbjct: 2393 --RTLEAERQRQ------LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 654 --GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE- 710
L +E+V ++Q E +Q + L + + +LE+EK+ ++ L+
Sbjct: 2445 HRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL 2498
Query: 711 ----------EELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQA 760
E+L QAL Q++L +D + LQ+E +A E +D A
Sbjct: 2499 KSEEMQTVQQEQLLQETQALQQSFLSEKD------SLLQRERFIEQEKAKLEQLFQDEVA 2552
Query: 761 AVEKVRRQILRQSREFDSQILRERMEL---LQQAQQRIRELEDKLEFQKRHLKELEEK 815
+++R + RQ ++ + +ER L +++A++R E E+ + ++ L++LE++
Sbjct: 2553 KAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Score = 96.3 bits (238), Expect = 1e-19
Identities = 190/843 (22%), Positives = 365/843 (43%), Gaps = 112/843 (13%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1442
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1443 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1494 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1547
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1548 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1601
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1661
Query: 341 --KKNEDLLQSIQRME-EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
K NE L +Q E + K+L + E K+K A+ +R + ++ + E
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQRE----- 1715
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L Q LE+Q + + + ++ + R ++ ET G + + E L+
Sbjct: 1716 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRA---------ETEQGEQQRQLLEEELA-- 1764
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
R R A + R+E + ++ E + L + A +E+ T +
Sbjct: 1765 -----RLQREAAAATQ------KRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--- 1810
Query: 518 EARTREQLQADLLRCQAKIEDLEKL--LVEKGQDSKWVEEKQLL---IRTNQDLLEKIYR 572
+++++L+A+ R + E+ +L L E+ + + + E+ + L EK+
Sbjct: 1811 --KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-NLQITTFPENHSSALQLFCH 631
+ E +LK E + A + E R+ L E E AF ++ H + ++
Sbjct: 1869 IG-EATRLKTEAEIALKEKEAENERLRRLAEDE----AFQRRRLEEQAAQHKADIEERLA 1923
Query: 632 QEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEG-TEAALTQ 690
Q ++ + SEL ++ ++ D LR QV +LAL + K G E L
Sbjct: 1924 Q--LRKASDSELERQKGLVED--TLRQRRQV----EEEILALKASFEKAAAGKAELELEL 1975
Query: 691 KMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEAL 750
+ E L S+++ LE + A ++ + + A ++E R+ AL
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 751 SEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLK 810
E +R L+A VE+ RR LR+ E +S +++L Q+A Q+ + E+K K
Sbjct: 2036 EEVER--LKAKVEEARR--LRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 811 ELE 813
E E
Sbjct: 2089 EQE 2091
Score = 89.0 bits (219), Expect = 2e-17
Identities = 151/692 (21%), Positives = 297/692 (42%), Gaps = 81/692 (11%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2058
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2059 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2218
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2219 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2329
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2390 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2447
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2506
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLE 600
+++QLL T LL++ +E E+ +L+ QD + + L + R +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566
Query: 601 LEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE 660
E+ER+ +++ H + + QE ++ + ++ + +N LR +
Sbjct: 2567 QMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 661 QVAIIQAGTVLALCEKWLKQIEGTEAALTQKM 692
Q+ Q LA E ++ ++ A T+ +
Sbjct: 2626 QLLEEQHRAALAHSE----EVTASQVAATKTL 2653
Score = 89.0 bits (219), Expect = 2e-17
Identities = 152/670 (22%), Positives = 278/670 (41%), Gaps = 82/670 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2128
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2129 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2231
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2472 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
Q + + +A+ + Q ++ + Q E+ ++ Q + +E+Q L+ + ++
Sbjct: 2531 QRE---RFIEQEKAKLEQLFQDEVAKAQQLREEQQR------QQQQMEQERQRLVASMEE 2581
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ + E + + E+Q + Q E + E +R R Q+ E H +A
Sbjct: 2582 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE------QLQLLEEQHRAA 2635
Query: 626 LQLFCHQEGV 635
L H E V
Sbjct: 2636 L---AHSEEV 2642
Score = 74.3 bits (181), Expect = 4e-13
Identities = 170/804 (21%), Positives = 326/804 (40%), Gaps = 133/804 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1200
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1201 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1254
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1255 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1295
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R ++ ++ IK + ++ + +L A +K +Q + E ++Q R H S
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYS-- 1351
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
EL + Q+ I ++ +R++E+ L +R E +R
Sbjct: 1352 -----------ELTTLTSQY------------IKFISETLRRMEEEERLAEQQRAEERER 1388
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
E E L EK +++ + + +R ++++ +E V +E+ + A ++ +
Sbjct: 1389 LAEVEAAL----EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
Query: 382 SLNDLSLTRDEQEIEF----LRLQVLEQQ--HVIDDLSLERERLLRSKRHRGKSLKPPKK 435
+L R E E + + E+ + +++ + R +L ++R RG
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-------- 1496
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
G + E +E E + A+EEA+ Q+ E
Sbjct: 1497 -------GAEGELQALRARAE---------------EAEAQKRQAQEEAERLRRQVQDES 1534
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
Q ++A L +V +A RE + R + LR QA E+ E+ L + + + +
Sbjct: 1535 QRKRQAEVELASRVKAEAEAARE-KQRALQALEELRLQA--EEAERRL--RQAEVERARQ 1589
Query: 556 KQLLIRTNQ-----DLLEKIYRLEMEENQLKNEMQD----AKDQNELLEFRVLELEERER 606
Q+ + T Q +L K + QL+ +Q+ E E R + E ER
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGV---KDVNVSELMKKLDILGDNGNLRNE-EQV 662
++ + + AL+L E V K + +E K+ + R + E+
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Query: 663 AIIQAGTVLALCEKWLKQIEGT---EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
A+ Q EK + EGT A Q+++ L E + +Q+ LEEEL ++
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Query: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
A K Q+LEA L + A +A +E E+ ++ EK ++++ ++ F +
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRF-RE 1825
Query: 780 ILRE--RMELLQQAQQRIRELEDK 801
+ E R+ L + +R R+L ++
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEE 1849
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2487
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2544
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2545 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2593
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2653 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2710 ARREDVRHY 2718
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2537 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2649
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2706
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2707 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2754
Score = 31.2 bits (69), Expect = 4.1
Identities = 71/366 (19%), Positives = 143/366 (39%), Gaps = 42/366 (11%)
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA----LLQEQVGGTLDAEREAR 520
++ A PE T R E +L +L + ++L Y + + GT AE R
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKL-EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1133
Query: 521 TREQ-------LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E+ + A L +A L+KL + + + +R Q++ E++ +
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1193
Query: 574 EMEEN-QLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQ 632
E + +++ + E + + + + R+R Q+ + E+ + L + Q
Sbjct: 1194 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES-ADPLGAWL-Q 1251
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVA--IIQAGTVLALCEKWLKQ----IEGTEA 686
+ + + M D LR E+ + I + G + C+++ KQ I+ E
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1311
Query: 687 ALTQKMLDLE------KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
L LE K+ + S + ++E +D R + L Q ++ T +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 741 EPGRRAGEALSEGQRE---DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRE 797
E R E +RE +++AA+EK R Q+ + QA++ +E
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQR------------QLAEAHAQAKAQAEREAKE 1419
Query: 798 LEDKLE 803
L+ +++
Sbjct: 1420 LQQRMQ 1425
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 117 bits (293), Expect = 4e-26
Identities = 195/848 (22%), Positives = 376/848 (44%), Gaps = 103/848 (12%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLEREQEQRRHTAYISELKAKLHEEKTK 82
E+L+ + Q E Q+E+ ++ KL R+ L+ + E EQ+Q+R +L+ K EE+ +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR-LRREQQLRRKQEEERRE 316
Query: 83 ELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR- 141
+ + RE R+ +QE R +++ + +R + L R+ ++ + L E EE R
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLR--REQEEERREQQLRREQEEERRE 374
Query: 142 -RAFDGERLRLQQEILELKAARKQAEEALSNCMQADK--TKAADLRAAYQ---AHQDEVH 195
+ ++LR +Q++ + R++ + ++ ++ + LR Q ++E H
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 196 RIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL---QKEALDEQLVQVKE 252
K E ER +RL E + + R L E+E + +K L Q+E E+ ++++E
Sbjct: 435 EQKHEQERREQRLKRE-QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQHMDER-----DVRRFQLKIAELNSVIRKLEDR 307
ER +RE +L Q++ ++R + R Q ++ + R+ E+R
Sbjct: 494 EERREQQERRE--------QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 308 NTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE-KIKNLTRENVE 366
R +LLKR E ++ + ++ KR ++ D Q ++R EE + + L RE E
Sbjct: 546 -------REQLLKREEEKRLEQERREQRLKREQEERRD--QLLKREEERRQQRLKREQEE 596
Query: 367 MKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRS---K 423
E+ + ++R L ++E+ + L+ + E++ R++LL+S +
Sbjct: 597 RLEQRLKREEVER--------LEQEERREQRLKREEPEEE--------RRQQLLKSEEQE 640
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
R + L+ ++ E +EE E + + +R ++ A E++ ARE
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE----QARER 696
Query: 484 ADLRF----CQLTREYQALQ-RAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIED 538
R QL E A Q + Y+ ++Q G E+E + R + +++L + +
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR-ESELQWQEEERAH 755
Query: 539 LEKLLVEKGQDSKW---VEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
++ E+ +D W EEK R Q L + E E QL+ E + ++Q L E
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKS--ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 596 FRVLELEERERRSPAFNLQITTFPE---NHSSALQLFCHQEGVKDVNVSELMKKLDILGD 652
E R+RR LQ E A QL ++G+++ E + + D
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE--DQERRRSQEQRRD 871
Query: 653 ---NGNLRNEE-------------QVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLE 696
L E Q + + +L E+ L++ E + ++
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 697 KEKDLFSRQKGYLEEELD-YRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQR 755
+E+ L ++ L EE + R+Q ++ Y K + L+ L +EP +R + + R
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 756 EDLQAAVEKVRRQILRQSR------EFDSQILRERMELLQQAQQRIRELEDKLEFQKRHL 809
E+ + +++ Q+LR+ R E++ Q R++ EL Q+ +Q +RE +K Q+R
Sbjct: 992 EEEE--LQQEEEQLLREEREKRRRQEWERQ-YRKKDELQQEEEQLLREEREKRRLQERER 1048
Query: 810 KELEEKFL 817
+ EE+ L
Sbjct: 1049 QYREEEEL 1056
Score = 109 bits (272), Expect = 1e-23
Identities = 204/885 (23%), Positives = 388/885 (43%), Gaps = 120/885 (13%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAK----LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
++ R K E+PE E + +EE + L Q E ++++ K + ERL++ +L+R
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ-RLKR 674
Query: 59 EQEQRRHTAYISELKAKLHEEKTK------ELQALREGLIRQ-------HEQEAARTAKI 105
E E+ R ++E + + E+ K + Q E RQ +QE R +
Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 106 KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAF------DGERLRLQQEILELK 159
+E + +R ++ L + A + + EE RR F + + R +Q +
Sbjct: 735 QEEKRRRRESELQWQEEERAHR------QQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 160 AARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRI-KRECERDIRRLMDE--IKGKD 216
R+Q E L +A++ + + R + + E R +RE E++++ L +E ++ ++
Sbjct: 789 PLREQRERQL----RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 217 RVILALEKELGVQAGQTQKLLLQKEALDE----QLVQVKEAERHHSSPKRELPPGIGDMV 272
R E+E G+Q Q ++ Q++ D+ QL + ++ RH K L +
Sbjct: 845 RAQQLQEEEDGLQEDQERRRS-QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 273 ELMGVQDQHM--DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+L+ +++ + +ER+ RR Q + + + ++ LL +ER + ++ RE + +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR-- 961
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
K+K++ +K E LL EE K R E ++K + L++ L R
Sbjct: 962 ----KDKKLQQKEEQLLG-----EEPEK---RRRQEREKKYREEEELQQEEE----QLLR 1005
Query: 391 DEQEIEFLRLQVLEQQH-VIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
+E+E R Q E+Q+ D+L E E+LLR +R + + + +++ E +EE +
Sbjct: 1006 EEREKR--RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 450 -DSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ 508
E + +R R +++ ++ REE + R Q RE Q R LQ++
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQE-EEQLLREEPEKRRRQ-ERERQC--REEEELQQE 1119
Query: 509 VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE 568
L ERE R R++L+ + ++ E+LL E+ + + E LE
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE------------LE 1167
Query: 569 KIYR----LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAF-------NLQITT 617
+ YR L+ EE QL E Q+ + Q ++R E +R++R + +L+
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 618 FPENHSSAL--QLFC---HQEGVKDVNVSELMKKLD------ILGDNGNLRNEEQVAIIQ 666
PE ++ +++C E + + S+L + +LG+ E++ Q
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 667 AGTVLALCEKWLKQIEGTEA------ALTQKMLDLEKEKDLFSRQ---KGYLEEELDYRK 717
E+ L++ E EA + +K L E+ ++ RQ + + EEE ++
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 718 QALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSRE-- 775
+ + +D + QE GR+ E +R++ + K +Q+ Q RE
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 776 ----FDSQILRERMELLQQAQQR-IRELEDKLEFQKRHLKELEEK 815
D + E +L +Q + R RE E ++ Q+R K LEE+
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Score = 103 bits (256), Expect = 9e-22
Identities = 186/900 (20%), Positives = 375/900 (41%), Gaps = 114/900 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLR----ERLQEAKLER 58
++ + + + + E Q E + + Q+ +QE+ + +LR E +E +L R
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 59 EQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIK------------ 106
EQE+ R + + E++ + Q LR + EQ+ R +++
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 107 ----------EGELQRLQATLNVLRDGAADKVKTALLTEAREEARR----AFDGERLRLQ 152
+ E +R + L ++ D +K TE E+ RR D E R +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 153 QEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEI 212
+ + + R++ +E ++ ++ + + R Q ++ + + R E+ +RR +E
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS-EQQLRREQEE- 544
Query: 213 KGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMV 272
+++++ E++ Q + Q+L ++E +QL++ +E ER KRE + +
Sbjct: 545 -RREQLLKREEEKRLEQERREQRLKREQEERRDQLLK-REEERRQQRLKREQEERLEQRL 602
Query: 273 ELMGVQDQHMDER-----------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
+ V+ +ER + RR QL +E R+ + R + R + LKR
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKR 661
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN-LTRENVEMKEKLSA-QASLKR 379
E E + L +++ ++ E + ++ E+IK+ + + +++ + A Q+ +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 380 HTSLNDLSLTRDEQEIEFLR----LQVLEQQHVIDDLSLERER-------LLRSKRHRGK 428
+ R EQE + R LQ E++ E +R K RG+
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 429 ---SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATARE--- 482
S +PP + E +E + PEE+ + R+
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRF---------------LPEEEEKEQRRRQRRE 826
Query: 483 -EADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEK 541
E +L+F + + Q +RA L +E+ G D ER R++EQ + R Q + E +
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR-RSQEQRRDQKWRWQLEEERKRR 885
Query: 542 ---LLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELL--EF 596
L + + +E+QLL Q+ E++ R E E+ + + + + +++ +L E
Sbjct: 886 RHTLYAKPALQEQLRKEQQLL----QEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 597 RVLELEERERRSPAFNLQITTFPENHSSALQLF-------CHQEGVKDVNVSELMKKLD- 648
++L E +RR Q + QL QE K E +++ +
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 649 --ILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQK 706
+ + R +E + L E+ L + E + L ++ +E++L ++
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 707 GYLEEELD-YRKQALDQAYLKIQDLEATLYTALQQEPGR----------RAGEALSEGQR 755
L EE + R+Q L++ Y K ++L+ L++EP + R E L + +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 756 EDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
+ L+ EK RRQ L + + ++ +E +LL++ ++ R E LE Q R +EL+++
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE--LERQYREEEELQQE 1179
Score = 99.8 bits (247), Expect = 9e-21
Identities = 191/901 (21%), Positives = 369/901 (40%), Gaps = 151/901 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH 65
R + E+ E + E + ++ E ++ + ++ K E ++ +L+REQE+R
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 66 TAYISELKAKLHEEKTKELQALRE--------GLIRQHEQEAARTAKIKEGELQRLQATL 117
E +L +E+ +E + RE L++ EQE R +++ + +R + L
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659
Query: 118 -----------NVLRDGAADKVKTALLTEAREEAR------------------------- 141
+ R+ ++ + L E +E+AR
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 142 ----RAFDGERLRLQQEILELKAARKQ----AEEALSNCMQADKTKAADLRAAYQAHQDE 193
R +G+R R +QE E + R+ EE ++ Q ++ + D +QA +
Sbjct: 720 YSRPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 194 VH---------RIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALD 244
++ + ER +R +E + +++ L E+E + Q ++ + + L+
Sbjct: 778 ERGRQRLSARPPLREQRERQLR--AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 245 EQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD-------ERDVRRFQLKIAEL 297
E+ Q++ ER + E G+ + E Q+Q D E + +R + +
Sbjct: 836 EE-EQLQRRERAQQLQEEE--DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 298 NSVIRKLEDRNTLLADERNELLKRSRE------------TEVQLKP------LVEKNKRM 339
++ +L LL +E EL + RE E QL+ E+ KR
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 340 NKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLR 399
++ E + +++++K + L E E + + + + L +E E R
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 400 LQVLEQQH-VIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEES-VDSETLSET 457
Q E+Q+ D+L E E+LLR +R + + + +++ E +EE + E +
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAER 517
+R R +++ ++ REE + R Q RE Q R LQ++ L ER
Sbjct: 1073 RQELERQYRKEEELQQE-EEQLLREEPEKRRRQ-ERERQC--REEEELQQEEEQLLREER 1128
Query: 518 EARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEE 577
E R R++L+ R + +++ E+ L+ + + + +E + R ++ L+ EE
Sbjct: 1129 EKRRRQELERQ-YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE-------LQQEE 1180
Query: 578 NQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKD 637
QL E Q+ + Q ++R E +R++R + E+ S L+ E
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYR------DEDQRSDLKWQWEPEKENA 1234
Query: 638 VNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEK 697
V +++ K NE+ +Q+E ++ Q DL+
Sbjct: 1235 VRDNKVYCK--------GRENEQ-----------------FRQLEDSQLRDRQSQQDLQ- 1268
Query: 698 EKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQ--R 755
L Q+ E+ R Q D+ + + + LE Q+E RR ++ E Q R
Sbjct: 1269 --HLLGEQQERDREQERRRWQQRDRHFPEEEQLE----REEQKEAKRRDRKSQEEKQLLR 1322
Query: 756 EDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIREL-EDKLEFQKRHLKELEE 814
E+ + EK RRQ + + Q+L+ER E + Q+R R+ E++L Q++ K LEE
Sbjct: 1323 EERE---EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Query: 815 K 815
+
Sbjct: 1380 E 1380
Score = 93.6 bits (231), Expect = 7e-19
Identities = 190/868 (21%), Positives = 354/868 (40%), Gaps = 118/868 (13%)
Query: 3 KKGRSKGEKPEMETDAVQMANEEL------------RAKLTSIQIEFQQEKSKV-GKLRE 49
K+ R + E+ + D +Q E+L R + + E QQE+ ++ G+ RE
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 50 RLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGE 109
+ +LER+ K E + +E Q LRE ++ QE R + +E E
Sbjct: 1070 TRRRQELERQYR-------------KEEELQQEEEQLLREEPEKRRRQERERQCR-EEEE 1115
Query: 110 LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERL-------RLQQEILELKAAR 162
LQ+ + L LR+ + + L + REE + E+L R +QE+
Sbjct: 1116 LQQEEEQL--LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++ ++ ++ ++ K R ++E+ R KR+ +R DE + D L
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK-----QRYRDEDQRSD---LKW 1225
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQ---- 278
+ E + + K +EQ Q+++++ +++L +G+ E Q
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 279 ----DQHM-DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRS------RETEV 327
D+H +E + R + K A+ RK ++ LL +ER E +R RE E
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRD--RKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 328 QLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSL---- 383
L+ E+ R +++ + R +E+ + E ++ + + LK L
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 384 NDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFG 443
+ L +D Q L +Q E +++ R +R R K L+ ++ E
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER-KFLEEEQQLRQERHRK 1462
Query: 444 FDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA 503
F EE + E + DR E+ L R+E D +F + Q +R +
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQL----RRQERDRKFREQELRSQEPERKFL 1518
Query: 504 LLQEQVGGTLDAEREARTREQLQAD-LLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRT 562
++Q+ R+ R R+ LQ + LR Q + + + +D K+ EE+QL
Sbjct: 1519 EEEQQL------HRQQRQRKFLQEEQQLRRQERGQQR-----RQDRDRKFREEEQLRQER 1567
Query: 563 NQDLL---EKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEE--RERRSPAFNLQITT 617
+ L E+ + +EE +++ + Q+ K + + R E ++ R+ R F
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 618 FPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKW 677
E L QE + L + LR +E+ ++ E+
Sbjct: 1628 LQEREEQQLH---RQE-----------RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 678 LKQIEGTEAALTQKMLD---LEKEKDL--FSRQKGYLEEELDYRKQALDQAYLKIQDLEA 732
EG E L ++ D E+E+ L R++ +L+EE R+Q L++ + + E
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE----EE 1729
Query: 733 TLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQ 792
L +QE RR + E L+ E+ +Q+ RQ R+ + RE +L Q+ +
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRP--EREEQQLRRQERD---RKFREEEQLRQERE 1784
Query: 793 Q---RIRELEDKLEFQKRHLKELEEKFL 817
+ R +E + K +++ +E EE+ L
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQL 1812
Score = 92.8 bits (229), Expect = 1e-18
Identities = 188/865 (21%), Positives = 355/865 (41%), Gaps = 124/865 (14%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQ--EAKLEREQ 60
K+ R + E+ + +Q E+L + + +QE+ K + E LQ E +L RE+
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGE--EPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
++R K E + +E Q LRE ++ QE R + +E Q + L
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQE---ILELKAARKQAEEALSNCMQADK 177
R+ T R+E R + E LQQE +L + +++ +E C + ++
Sbjct: 1068 RE-----------TRRRQELERQYRKEE-ELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+ + + ++ R ++E ER R +E++ ++ +L E E + + ++
Sbjct: 1116 LQQEEEQL---LREEREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKR-RRQELERQY 1170
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE--RDVRRFQLKIA 295
++E L ++ Q+ E+ +RE + ++ + ++ DE R ++Q +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 296 ELNSVIRKLEDRNTLLADERNELLK-------RSRETEVQLKPLVEKNKRMNKKNEDLL- 347
+ N+V D NE + R R+++ L+ L+ + + +++ E
Sbjct: 1231 KENAV----RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 348 ----------QSIQRMEEK-IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIE 396
+ ++R E+K K R++ E K+ L + KR D +EQ ++
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 397 FLRLQVLEQQHVIDDLSLERERLLRSK--RHRGKSLK------PPKKHVVETFFGFDEES 448
Q L +Q ER+R R + RH+ + K ++ E F +E+
Sbjct: 1347 EREEQPLRRQ--------ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 449 VDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ 508
+ + E DR DR E+ L +R+E D +F + ++ + +R L+E+
Sbjct: 1399 LRCQE-REQQLRQDR-DRKFREEEQQL----SRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 509 VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE 568
+ R+ R EQL E E+ L + +D K++EE+Q L R +D
Sbjct: 1453 QQLRQERHRKFREEEQLLQ---------EREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 569 KIYRLEM---------EENQLKNEMQDAKDQNELLEFRVLE--LEERERRSPAFNLQITT 617
+ L EE QL + + K E + R E + R+ R F +
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 618 FPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKW 677
E L QE + + E +K+ +EQ Q G ++
Sbjct: 1564 RQEREEQQLS---RQERDRKFRLEE--QKVRRQEQERKFMEDEQQLRRQEG------QQQ 1612
Query: 678 LKQIEGTEAALTQKMLDLEKEKDLF--SRQKGYLEEELDYRKQALDQAYLKIQDLEATLY 735
L+Q + +++L +E+ L R + +LEEE R+Q +Q +D +
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF--- 1669
Query: 736 TALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERME--LLQQAQQ 793
R + L EG+ + L+ R++ R+ RE + Q+ R+ E LQ+ QQ
Sbjct: 1670 --------REEEQLLQEGEEQQLR------RQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 794 -RIRELEDKLEFQKRHLKELEEKFL 817
R +ELE K +++ +E E++ L
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQL 1740
Score = 90.9 bits (224), Expect = 4e-18
Identities = 178/843 (21%), Positives = 328/843 (38%), Gaps = 150/843 (17%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ---------EQRRHTAYISELK 73
+EE RA+ + Q + + + R ++ +LE E EQ R A E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 74 AKLHEEKTKELQALREGLIRQHEQEAAR-----------------TAKIKEGELQRLQAT 116
K + ++ Q E L RQ ++ R T + + E R +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGER----------LRLQQEILELKAARKQAE 166
L + R G +K + + RE R F E LR ++E L+ + ++Q
Sbjct: 216 LELRRKGREEKQQ-----QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ-R 269
Query: 167 EALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226
E Q K + +LR Q + + R++R E+ +RR +E + + + ++E
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRR--EQQLRRKQEEERREQQEERREQQER 327
Query: 227 GVQAGQTQKLLL---QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
Q + ++ L Q+E ++QL + +E ER +RE Q++
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE--------------QEEERR 373
Query: 284 ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKN 343
E+ +RR Q E + R L E+ ++ E QL+ + + ++
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 344 EDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRH-TSLNDLSLTRDEQEIEFLRLQV 402
+ +R E+++K RE E ++ L + +RH L RD++E R
Sbjct: 434 HEQKHEQERREQRLK---REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 403 LEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
LE++ + ++L R + R + ++ +EE + SE +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQE---------EEERLQQRLRSEQQLRRE 541
Query: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
+ +R + + E + R Q RE Q L+R ++Q+ + R+ R +
Sbjct: 542 QEERR---------EQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKREEERRQQRLK 591
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
+ Q + L + K E++E+L E+ ++ + E+ R Q LL+ + E + QL+
Sbjct: 592 RE-QEERLEQRLKREEVERLEQEERREQRLKREEPEEER-RQQLLKSEEQEERRQQQLRR 649
Query: 583 EMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSE 642
E Q+ ++Q E LE+R +R H+E ++ ++E
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKRE----------------------HEEERREQELAE 687
Query: 643 LMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLF 702
EEQ + + + KW Q+E A K+ +
Sbjct: 688 ----------------EEQEQARE--RIKSRIPKWQWQLESEADARQSKVYSRPR----- 724
Query: 703 SRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRR------AGEALSEGQRE 756
+Q+G + K+ ++ L+ Q+ E + Q+E RR E SE R+
Sbjct: 725 -KQEGQRRRQEQEEKRRRRESELQWQE-EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 757 DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKF 816
L A R LR+ RE + R E QQ +QR E++ E ++R +E E++
Sbjct: 783 RLSA------RPPLREQRE-----RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 817 LFL 819
FL
Sbjct: 832 QFL 834
Score = 87.0 bits (214), Expect = 6e-17
Identities = 145/628 (23%), Positives = 270/628 (42%), Gaps = 81/628 (12%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTK 82
NE+ R +L Q+ +Q + + L QE +REQE+RR + E+ +
Sbjct: 1247 NEQFR-QLEDSQLRDRQSQQDLQHLLGEQQER--DREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 83 ELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARR 142
+ +A R Q E++ R + E +R Q T R+ + LL E E+ R
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREER---EEKRRRQETDRKFRE------EEQLLQEREEQPLR 1354
Query: 143 AFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAH-QDEVHRIKREC 201
+ +R ++E+ + RK EE ++ + + L+ Q Q+ +++++
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEE--EQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R R ++ ++R E+E V+ + ++ L++E +QL Q ERH +
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE---QQLRQ----ERHRKFRE 1465
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRF-----QLKIAELNSVIRKLEDRNT----LLA 312
E +++ Q H ERD R+F QL+ E + R+ E R+
Sbjct: 1466 EE------QLLQEREEQQLHRQERD-RKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 313 DERNELLKRSRETE-VQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
+E +L ++ R+ + +Q + + + +R ++ +D + R EE+++ E +E+
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF-REEEQLRQ------EREEQQ 1571
Query: 372 SAQASLKRHTSLNDLSLTRDEQEIEFLR-LQVLEQQHVIDDLSLERERLLRSKRHRGKSL 430
++ R L + + R EQE +F+ Q L +Q L ER+R R +
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 431 KPPKKHVVETFFGFDEESVD---SETLSETSYNTDRTDRTPATP-EEDLDDATAREEADL 486
+ + H E F EE E + ++ DR R +E + R+E D
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 487 RFCQLTREYQALQRAYALLQE-QVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVE 545
+F + ++ + +R LQE Q + ER+ R EQL+ + + Q + ++ + ++E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 546 KGQ---------------DSKWVEEKQLLIRTNQDLL-----------EKIYRLEMEENQ 579
+ Q D K+ EE+QL + L E+ R E EE Q
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 580 LKNEMQDAKDQNELLEFRVLELEERERR 607
L+ + +D K + E L+LEE+E+R
Sbjct: 1812 LRPQQRDGKYR---WEEEQLQLEEQEQR 1836
Score = 83.2 bits (204), Expect = 9e-16
Identities = 181/859 (21%), Positives = 347/859 (40%), Gaps = 102/859 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQ-QEKSKVGKLRERLQEAKLEREQE 61
++ R E+ E++ + Q+ EE R K ++E Q +E+ +V + E+L L E E
Sbjct: 1105 ERERQCREEEELQQEEEQLLREE-REKRRRQELERQYREEEEVQQEEEQL----LREEPE 1159
Query: 62 QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIK----EGELQRLQATL 117
+RR EL+ + EE+ ELQ E L+R+ EQE R + + E ELQR +
Sbjct: 1160 KRRR----QELERQYREEE--ELQQEEEQLLRE-EQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 118 NVLRDGAADKVKTALLTEAREEAR------RAFDGERLR-LQQEILELKAARKQAEEALS 170
+ +K E R + + E+ R L+ L + +++ + L
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 171 NCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQA 230
+ D+ + H E +++RE +++ +R D +++ +L E+E +
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQLLREEREEKRRR 1331
Query: 231 GQTQKLLLQKEAL----DEQLVQVKEAERHHSSPK-RELPPGIGDMVELMGVQDQHMDER 285
+T + ++E L +EQ ++ +E +R + R G + E ++ Q + +
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 286 DVRRFQ-LKIAELNSVIRKLEDRNTLLADE---RNELLKRSRETEVQLK----------- 330
++ Q L+ E +R+ DR ++ R E ++ RE E Q++
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 331 --PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSL 388
L ++ R ++ E LLQ + + + R+ +E +++L Q +R + L
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ---ERDRKFREQEL 1508
Query: 389 TRDEQEIEFLRL-QVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEE 447
E E +FL Q L +Q E ++L R +R + + +K F EE
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK--------FREE 1560
Query: 448 SVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQE 507
+ E + DR E+ + R+E + +F + ++ + + L QE
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKV----RRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 508 QVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLL--------VEKGQDSKWVEEKQLL 559
+ + E+ + RE+ Q K + E L + +D K+ EE+QLL
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676
Query: 560 IRTNQDLL---EKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQIT 616
+ L E+ + EE QL+ + ++ K E + R ELE + R +
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736
Query: 617 TFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEK 676
+ +E ++ + +++ + + R EEQ
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQE---RDRKFREEEQ--------------- 1778
Query: 677 WLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYT 736
L+Q E E L + D + ++ RQ+ EE R Q D Y ++
Sbjct: 1779 -LRQ-EREEQQLRSQESDRKFREEEQLRQE---REEQQLRPQQRDGKYRWEEE-----QL 1828
Query: 737 ALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIR 796
L+++ R E + + E+ A EK RR+ +E + + +ER L++ R +
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 797 ELEDKLEFQKRHLKELEEK 815
+ E++ Q +K E K
Sbjct: 1889 QKEEQRHRQVGEIKSQEGK 1907
Score = 41.6 bits (96), Expect = 0.003
Identities = 82/336 (24%), Positives = 133/336 (39%), Gaps = 56/336 (16%)
Query: 495 YQALQRAYALLQEQVGGTLDAEREART--REQL------QADLLRCQAKIEDLEKLLVEK 546
++ Q Y L + G LD E+ AR +E L + D R + + LE+ ++
Sbjct: 79 FKVAQACYYALGQATG--LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR 136
Query: 547 GQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERER 606
+ + +E++L Q EK RLE + Q ++E EL R E ER
Sbjct: 137 RRQKRQEQERELAEGEEQS--EKQERLEQRDRQRRDE--------ELWRQRQEWQEREER 186
Query: 607 RSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQ 666
R+ LQ E F +E ++ + EL +K + R E Q + Q
Sbjct: 187 RAEEEQLQSCKGHETEE-----FPDEEQLRRRELLELRRKGR--EEKQQQRRERQDRVFQ 239
Query: 667 AGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQ---- 722
++W K+ + +L E+EK L+EE R++ L +
Sbjct: 240 EEEE----KEWRKR---------ETVLRKEEEK---------LQEEEPQRQRELQEEEEQ 277
Query: 723 -AYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILR--QSREFDSQ 779
L+ Q+L QQ+ R + L Q E+ + E+ R Q R Q E Q
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 780 ILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
LR E ++ Q R + E++ E Q R +E E +
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 113 bits (282), Expect = 8e-25
Identities = 138/602 (22%), Positives = 258/602 (42%), Gaps = 80/602 (13%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
++ + Q+ N EL K E Q + RE+LQ KL+RE++ A+ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ--REKLQREKLQREKDMLLAEAF--SL 1498
Query: 73 KAKLHE---------EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K +L E +K L+A + + Q ++ A AK+K+ +L+ L+A + +
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK-QLRDLEAKVKDQEEE 1557
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
++ T + E + + R + ER+R Q E+++ ++ EEA +C + K L
Sbjct: 1558 LDEQAGTIQMLE-QAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
Y+ Q +V R KRE E + L D++ +D EK L +T+ LL + +
Sbjct: 1616 EEEYEDKQ-KVLREKRELEGKLATLSDQVNRRD---FESEKRLRKDLKRTKALLADAQLM 1671
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
+ L ++R + K +L + V+ + E ++ L+I ++
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEES--EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE 363
LE++ + L E+NE+ R E + + L++K+K + L I ++ +++ +E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 364 NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK 423
E++EKL A S ++EFL +Q ++D + R+
Sbjct: 1790 KQELQEKLQALQS-----------------QVEFL------EQSMVDKSLVSRQEA---- 1822
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
K +ET F+ V R + + +E+++ T EE
Sbjct: 1823 ----------KIRELETRLEFERTQVK------------RLESLASRLKENMEKLT--EE 1858
Query: 484 ADLRFCQLTREYQA---LQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDL 539
D R RE + LQR +E++G E EA R + +L+ DL +A + L
Sbjct: 1859 RDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSL 1918
Query: 540 E---KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEF 596
+ KL ++ D + E ++ N+DL+ + + + + KN+++ D + LE
Sbjct: 1919 QADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELED 1978
Query: 597 RV 598
RV
Sbjct: 1979 RV 1980
Score = 81.3 bits (199), Expect = 3e-15
Identities = 170/843 (20%), Positives = 340/843 (40%), Gaps = 158/843 (18%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
VQ++ E++R K E QQ +SK+ K + E +L ++ + R ISEL ++L +
Sbjct: 1249 VQLSEEQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESR----ISELTSELTD 1300
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
E+ A + L+ E R K E++ LQ + L+ +V + EAR
Sbjct: 1301 ERNTGESASQ--LLDAETAERLRAEK----EMKELQTQYDALKKQM--EVMEMEVMEARL 1352
Query: 139 EARRAFDGE----------RLRLQQEILELKAARKQAEEALSNCMQAD-------KTKAA 181
+GE RL+ ++ + E+ +K+ ++ + ++ + + +
Sbjct: 1353 IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLG 1412
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKE 241
DL+A + Q + ++K++C+R L D + L Q + +L ++
Sbjct: 1413 DLQADSEESQRALQQLKKKCQRLTAELQD-----------TKLHLEGQQVRNHELEKKQR 1461
Query: 242 ALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDER--DVRRFQLKIAELNS 299
D +L Q E + + +L ++ Q ++E+ D+ F K+ L +
Sbjct: 1462 RFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEA 1521
Query: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
+L+D ++ + + L K + QL+ L K K ++ ++ +IQ +E+
Sbjct: 1522 ---ELQDISSQESKDEASLAK----VKKQLRDLEAKVKDQEEELDEQAGTIQMLEQ---- 1570
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLR---LQVLEQQHV-IDDLSLE 415
KL + ++R + + ++E+E R + L+Q V +++ +
Sbjct: 1571 ---------AKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1621
Query: 416 RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDL 475
++++LR KR L TLS D+ +R E+ L
Sbjct: 1622 KQKVLREKRELEGKL---------------------ATLS------DQVNRRDFESEKRL 1654
Query: 476 DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAERE-ARTREQLQADLLRCQA 534
R +A L Q L+ + + + ++RE A+ + QL+ C A
Sbjct: 1655 RKDLKRTKALLADAQ-------------LMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1701
Query: 535 KIEDLEKLLVEKGQDSKWVEEKQLLI----RTNQDLLEKIYRLEMEENQLKNEM-QDAKD 589
++ + + VE +E+ L I + L E++ RL+ E+N+++N + +D +D
Sbjct: 1702 AVKARKAMEVE-------IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQED 1754
Query: 590 QNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDI 649
NEL++ + + R N E + +L QE + L +++
Sbjct: 1755 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL---QE-----KLQALQSQVEF 1806
Query: 650 LGD---NGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKD------ 700
L + +L + ++ I + T L +K++E + L + M L +E+D
Sbjct: 1807 LEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAE 1866
Query: 701 --------LFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSE 752
RQ +EE+ + +A K +LE L + +A L+
Sbjct: 1867 NREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAF 1926
Query: 753 GQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKEL 812
+ DLQAA+E E +S + + LQ + ++ ++KLE EL
Sbjct: 1927 KRIGDLQAAIED----------EMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSEL 1976
Query: 813 EEK 815
E++
Sbjct: 1977 EDR 1979
Score = 58.2 bits (139), Expect = 3e-08
Identities = 112/564 (19%), Positives = 229/564 (40%), Gaps = 77/564 (13%)
Query: 323 RETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE---------------NVEM 367
R + +++ L K ++ K+ +L + R+E +I LT E + E
Sbjct: 1257 RNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAET 1316
Query: 368 KEKLSAQASLKR-HTSLNDLSLTRDEQEIEFLRLQVLEQQHV---IDDLSLERERLLRSK 423
E+L A+ +K T + L + E+E + +++ + +DD E L+ +
Sbjct: 1317 AERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYE 1376
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPE-----EDLDDA 478
R + + KK + + F E+ ++ E ++ D + E + L
Sbjct: 1377 R-AVREVDFTKKRLQQEF----EDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKK 1431
Query: 479 TAREEADLRFCQL------TREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
R A+L+ +L R ++ ++ E +A+RE RE+LQ +
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 533 QAKIEDLEKLLVEKGQDSKWVEEKQLLIRTN-QDLLEKIYRLEMEENQLKNEMQD----A 587
A+ L++ L EK D +K + + QD+ + + E ++K +++D
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV 1551
Query: 588 KDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCH---------QEGVKDV 638
KDQ E L+ + ++ E+ +++ + HS ++ Q+ +K +
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 639 NVS---ELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWL-KQIEGTEAALT--QKM 692
V E K +L + L + Q EK L K ++ T+A L Q M
Sbjct: 1612 EVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLM 1671
Query: 693 LDLEKEKDLFSRQKGYLEEELDYRKQA--------------LDQAYLKIQDLEATLYTAL 738
LD K R+ L+ +L+ + ++ +L+I D+ A TAL
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDI-AKAKTAL 1730
Query: 739 QQEPGRRAGEALS-----EGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQ 793
+++ R E E +ED+ ++K + + + SR+ + + L++A +
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ--INDLQAQLEEANK 1788
Query: 794 RIRELEDKLEFQKRHLKELEEKFL 817
+EL++KL+ + ++ LE+ +
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMV 1812
Score = 54.3 bits (129), Expect = 5e-07
Identities = 107/500 (21%), Positives = 202/500 (40%), Gaps = 107/500 (21%)
Query: 333 VEKNKRMNKKNEDL-----------LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
V+KN + NK +D L +Q EE+I+N E +++ KL K
Sbjct: 1221 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLE-----KAEK 1275
Query: 382 SLNDLSLTRD--EQEIEFLRLQVLEQQHVIDD----LSLERERLLRSKRHRGKSLKPPKK 435
N+L L D E I L ++ ++++ + L E LR+++ K L+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEM-KELQTQYD 1334
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
+ + + E +++ + N + +DD A E L++ + RE
Sbjct: 1335 ALKKQMEVMEMEVMEARLIRAAEINGE------------VDDDDAGGEWRLKYERAVREV 1382
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
++ LQ++ L+ E++ + QL+ L QA E+ ++ L
Sbjct: 1383 DFTKKR---LQQEFEDKLEVEQQ--NKRQLERRLGDLQADSEESQRAL------------ 1425
Query: 556 KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQI 615
Q L +K RL E +QD K E + R ELE+++RR
Sbjct: 1426 --------QQLKKKCQRLTAE-------LQDTKLHLEGQQVRNHELEKKQRR-------- 1462
Query: 616 TTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCE 675
F S A H+E ++ E L+ E+ + + +A ++ +
Sbjct: 1463 --FDSELSQA-----HEEAQREKLQRE------------KLQREKDMLLAEAFSL----K 1499
Query: 676 KWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLY 735
+ L++ + A TQK++ LE E S Q+ E L K+ L K++D E
Sbjct: 1500 QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE---- 1555
Query: 736 TALQQEPGRRAGEA-LSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQR 794
+E +AG + E + L+ +E++R+ ++ D ++ R ++ +Q
Sbjct: 1556 ----EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 795 IRELEDKLEFQKRHLKELEE 814
+LE++ E +++ L+E E
Sbjct: 1612 EVQLEEEYEDKQKVLREKRE 1631
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 106 bits (264), Expect = 1e-22
Identities = 191/869 (21%), Positives = 379/869 (43%), Gaps = 115/869 (13%)
Query: 11 KPEMETDAVQMANEELRAKLTSIQ------IEFQQEKSKVGKLRERLQEAKLEREQEQRR 64
K EME ++ EELR + S++ ++ ++E ++ K E L E ++ +E++ +
Sbjct: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-ENEIVQEKQSLQ 522
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD-- 122
+ +S+ K + K ++ LRE RQ KI E E + L T++ LR
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQ--------IKILEQENEHLNQTVSSLRQRS 574
Query: 123 --GAADKVK-----TALLTEAREEARRAF---DGERLRLQQEILELKAARKQAEEALSNC 172
A +VK +L E+ +E + E+ ++++E+ K ++AEE +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 173 MQADKT------KAADLRAA---YQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
+K K +L+ +A + E ++RE R +++ +D K + +LE
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLE 693
Query: 224 KELGVQAGQTQKLLLQKEAL---DEQLVQVKEAERHHSSPKRELPPGIGDM------VEL 274
KE + +L E+L ++ Q++ + S K +L G+ + E
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 275 MGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE 334
+ V Q +D + +R Q + N I++LE L E L K E ++ K L
Sbjct: 754 LEVSYQGLDIEN-QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-- 810
Query: 335 KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQE 394
+++ K+N+ L Q ++E+ K L +EN ++L QA +K T +E
Sbjct: 811 --EQLEKENKSLEQETSQLEKDKKQLEKEN----KRLRQQAEIK--------DTTLEENN 856
Query: 395 IEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVE--TFFGFDEESVDSE 452
++ L+ E + + ++ + +E +R K ++ + K+ ++ T E+ V SE
Sbjct: 857 VKIGNLEK-ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SE 914
Query: 453 TLSETSYNTD------RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQ 506
L N D ++ E L D + +++ + + E L+++ + +
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE-STLKKSLEIKE 973
Query: 507 EQVGGTLDAEREARTR--EQLQADLLRCQAKIEDLEKLLVEK----------GQDSKWVE 554
E++ L+A E T +QL+ +L + E L++ E+ G+D+KW
Sbjct: 974 EKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 555 EKQLLIR---TNQDLLEKIYR----LEMEENQLKNEMQDAKDQNELLEFRVLELEERERR 607
E Q R +D L ++ R L+ E+ LK +++ + QN L+ ++L L +R+
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL---QRQ 1089
Query: 608 SPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQA 667
+ + Q TT + ++ LQ+ + + S + + +L +L NE + I +
Sbjct: 1090 TVSLQEQNTTL-QTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146
Query: 668 GTVLALCEKWLKQIEGTEAALTQKMLDLE----KEKDLFSRQKGYLEE--ELDYRKQALD 721
+ +L + +K E E ++ + E K L S K E +L+ R L
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 722 QAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQIL 781
+ +++DLE L ++QE L E + A +K+ + R + + SQ+L
Sbjct: 1207 KQKGQLEDLEKML--KVEQEK-----MLLENKNHETVAAEYKKLCGENDRLNHTY-SQLL 1258
Query: 782 RERMELLQQAQQRIRELEDKLEFQKRHLK 810
+E E+LQ + ++ L + + ++ L+
Sbjct: 1259 KE-TEVLQTDHKNLKSLLNNSKLEQTRLE 1286
Score = 90.9 bits (224), Expect = 4e-18
Identities = 169/818 (20%), Positives = 338/818 (41%), Gaps = 106/818 (12%)
Query: 35 IEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQ 94
IE +E+ + L A+ + T L +L + K K ++ LR+ L +
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAK-IRRLRQELEEK 270
Query: 95 HEQ--EAARTAKIKEGELQRLQA-TLNVLRDGAADKVKTALLTEAREEARRA--FDGERL 149
EQ + + + E EL+RLQ +N+L D + ++ L RE+A R + E
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 150 RLQQEILELKAARKQAEEALSN--CMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRR 207
R ++ + +++ + + EE + + KT D +A D++H +++E + +
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 208 LMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAER-HHSSPKRELPP 266
L D +D +E+ + + T ++ QK+++DE L E E+ +S E P
Sbjct: 391 LHDMEMERDMDRKKIEELM--EENMTLEMA-QKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 267 GIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETE 326
+ +G + + + + +++ L + +L + +++LK +E
Sbjct: 448 ------KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-- 499
Query: 327 VQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVE-MKEKLSAQASLKRHTSLND 385
N+R++KK E L I + ++ ++N + + MKEK + +++ +L +
Sbjct: 500 ---------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE---TLRE 547
Query: 386 LSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFD 445
S E++I+ L E +H+ +S R+R S R K ++
Sbjct: 548 NS----ERQIKILEQ---ENEHLNQTVSSLRQRSQISAEARVKDIEK------------- 587
Query: 446 EESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALL 505
E + E++ ETS + + +++L+ + E R +L E L++ LL
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKENELL 644
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIE-----------DLEKLLVEKGQDSKWVE 554
Q+++ + EQ ++L R K++ LE L E Q ++
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ----LD 700
Query: 555 EKQLLIRTNQDLLE----KIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPA 610
E+ L +R N + L+ K+ +L++E +L++E + K ELL+ + E E
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 611 FNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV 670
+++ + LQ K + ++ L++ EE
Sbjct: 761 LDIE--------NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE---------- 802
Query: 671 LALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDL 730
L + K L+Q+E +L Q+ LEK+K ++ L ++ + + L++ +KI +L
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 731 EATLYT-----ALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQ---SREFDSQILR 782
E T + +E R E E + +A ++ LR+ S + +Q +
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 783 ERMELLQQAQQRI-----RELEDKLEFQKRHLKELEEK 815
+E L ++I R L D+ K LE K
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Score = 85.1 bits (209), Expect = 2e-16
Identities = 170/855 (19%), Positives = 365/855 (42%), Gaps = 156/855 (18%)
Query: 33 IQIEFQQEKSKVGKLRERLQE--------------AKLEREQEQRRHTAYISELK-AKLH 77
+ +E K+K+ +LR+ L+E ++E ++ Q+ + +S+ + A+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 78 EEKTKELQALREGLIRQHEQEAARTAKIKE--GELQRLQATLNVLRDGAADKVKTALLTE 135
+ EL ALRE +R + E + ++ KE +++ +A + L++ ++T + E
Sbjct: 309 RD---ELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 136 AREEARRAFDGERLRLQQEILELKAA-----------RKQAEEALSNCMQADKTKAADL- 183
+ E RA + L++E L+LKA RK+ EE + M + + +
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 184 -------------------RAAYQAHQDEVHR------IKRECE--------RDIRRLMD 210
A ++ EV+ +K E E ++R +D
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 211 EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGD 270
++G IL +EKE Q+L + E L+ ++VQ K++ ++ + ++L
Sbjct: 485 SVEGNASKILKMEKE-------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 271 MVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+ + + ++ ER ++ + + LN + L R+ + A E ++K
Sbjct: 538 LEKTIETLREN-SERQIKILEQENEHLNQTVSSLRQRSQISA-------------EARVK 583
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
+ ++NK +++ ++ + ++E + + + +E KEK L+ N+L
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE-----NELHHLE 638
Query: 391 DEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD 450
E E+ Q I +L + E+ + + L+ + + +T F +
Sbjct: 639 KENEL---------LQKKITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAR-EEADLRFCQLTREYQALQRAYALLQEQV 509
E+L + + D + E L A+ + + L +L E + L++ LL+
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 510 -----------GGTLDAEREARTREQLQADLLRCQAKIEDL--EKLLVEKGQDSKWVEEK 556
G ++ +R +T E + + +++++DL E ++K + + K
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 557 QL--LIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQ 614
+L L + N+ L ++ +LE ++ QL+ E + + Q E+ + LEE N++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEEN-------NVK 858
Query: 615 ITTF-PENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQV--AIIQAGTVL 671
I EN + + ++ ++E V + EL K+ N+E V A I T++
Sbjct: 859 IGNLEKENKTLSKEIGIYKESC--VRLKELEKE-----------NKELVKRATIDIKTLV 905
Query: 672 ALCEKWLKQIEGTEAALTQKM-LDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQD- 729
L E + +E TQ+M DLEK + G +E L + +Q+ D + K+ +
Sbjct: 906 TLREDLV-----SEKLKTQQMNNDLEKLTHELEK-IGLNKERLLHDEQSTDDSRYKLLES 959
Query: 730 -LEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELL 788
LE+TL +L+ + + A E + E+ +++R+++ + +++ R+ E +
Sbjct: 960 KLESTLKKSLEIKEEKIAA---LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 789 QQAQQRIRELEDKLE 803
Q+ I ++K E
Sbjct: 1017 VQSSPPISGEDNKWE 1031
Score = 31.6 bits (70), Expect = 3.2
Identities = 33/184 (17%), Positives = 85/184 (46%), Gaps = 8/184 (4%)
Query: 15 ETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
ET+ +Q ++ L++ L + ++E + +++ KL+E+ Q+ + + +S+LK
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-TSTKLNNQCELLSQLKG 1318
Query: 75 KLHEEKTKELQALREGLIRQHE--QEAARTAKIKEGELQRLQATLNVLRDGAADKVKTAL 132
L EE L ++ +++ ++ + + E ++ LN LR +K++ +
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR-RQKEKLEEKI 1377
Query: 133 LTEAR----EEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
+ + + RR + L++++ I K ++ +++L+ + L+ +Q
Sbjct: 1378 MDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
Query: 189 AHQD 192
QD
Sbjct: 1438 DSQD 1441
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 105 bits (263), Expect = 1e-22
Identities = 191/866 (22%), Positives = 375/866 (43%), Gaps = 110/866 (12%)
Query: 11 KPEMETDAVQMANEELRAKLTSIQ------IEFQQEKSKVGKLRERLQEAKLEREQEQRR 64
K EME ++ EELR + S++ ++ ++E ++ K E L E ++ +E++ +
Sbjct: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-ENEIVQEKQSLQ 522
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD-- 122
+ +S+ K + K ++ LRE RQ KI E E + L T++ LR
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQ--------IKILEQENEHLNQTVSSLRQRS 574
Query: 123 --GAADKVK-----TALLTEAREEARRAF---DGERLRLQQEILELKAARKQAEEALSNC 172
A +VK +L E+ +E + E+ ++++E+ K ++AEE +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 173 MQADKT------KAADLRAA---YQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
+K K +L+ +A + E ++RE R +++ +D K + +LE
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLE 693
Query: 224 KELGVQAGQTQKLLLQKEAL---DEQLVQVKEAERHHSSPKRELPPGIGDM------VEL 274
KE + +L E+L ++ Q++ + S K +L G+ + E
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 275 MGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE 334
+ V Q +D + +R Q + N I++LE L E L K E ++ K L
Sbjct: 754 LEVSYQGLDIEN-QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-- 810
Query: 335 KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQE 394
+++ K+N+ L Q ++E+ K L +EN ++L QA +K T +E
Sbjct: 811 --EQLEKENKSLEQETSQLEKDKKQLEKEN----KRLRQQAEIK--------DTTLEENN 856
Query: 395 IEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVE--TFFGFDEESVDSE 452
++ L+ E + + ++ + +E +R K ++ + K+ ++ T E+ V SE
Sbjct: 857 VKIGNLEK-ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SE 914
Query: 453 TLSETSYNTDRTDRTPATPEEDLDDATA---REEADLRFCQLTREYQALQRAYALLQEQV 509
L N D T + L+ + D R+ L + ++ + ++E+
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEK 974
Query: 510 GGTLDAEREARTR--EQLQADLLRCQAKIEDLEKLLVEK----------GQDSKWVEEKQ 557
L+A E T +QL+ +L + E L++ E+ G+D+KW E Q
Sbjct: 975 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1034
Query: 558 LLIR---TNQDLLEKIYR----LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPA 610
R +D L ++ R L+ E+ LK +++ + QN L+ ++L L +R++ +
Sbjct: 1035 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL---QRQTVS 1091
Query: 611 FNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV 670
Q TT + ++ LQ+ + + S + + +L +L NE + I + +
Sbjct: 1092 LQEQNTTL-QTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 671 LALCEKWLKQIEGTEAALTQKMLDLE----KEKDLFSRQKGYLEE--ELDYRKQALDQAY 724
+L + +K E E ++ + E K L S K E +L+ R L +
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208
Query: 725 LKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRER 784
+++DLE L ++QE L E + A +K+ + R + + SQ+L+E
Sbjct: 1209 GQLEDLEKML--KVEQEK-----MLLENKNHETVAAEYKKLCGENDRLNHTY-SQLLKE- 1259
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLK 810
E+LQ + ++ L + + ++ L+
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Score = 91.3 bits (225), Expect = 3e-18
Identities = 176/837 (21%), Positives = 347/837 (41%), Gaps = 122/837 (14%)
Query: 35 IEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQ 94
IE +E+ + L A+ + T L +L + K K ++ LR+ L +
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAK-IRRLRQELEEK 270
Query: 95 HEQ--EAARTAKIKEGELQRLQA-TLNVLRDGAADKVKTALLTEAREEARRA--FDGERL 149
EQ + + + E EL+RLQ +N+L D + ++ L RE+A R + E
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 150 RLQQEILELKAARKQAEEALSN--CMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRR 207
R ++ + +++ + + EE + + KT D +A D++H +++E + +
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 208 LMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAER-HHSSPKRELPP 266
L D +D +E+ + + T ++ QK+++DE L E E+ +S E P
Sbjct: 391 LHDMEMERDMDRKKIEELM--EENMTLEMA-QKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 267 GIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETE 326
+ +G + + + + +++ L + +L + +++LK +E
Sbjct: 448 ------KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-- 499
Query: 327 VQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVE-MKEKLSAQASLKRHTSLND 385
N+R++KK E L I + ++ ++N + + MKEK + +++ +L +
Sbjct: 500 ---------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE---TLRE 547
Query: 386 LSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFD 445
S E++I+ L E +H+ +S R+R S R K ++
Sbjct: 548 NS----ERQIKILEQ---ENEHLNQTVSSLRQRSQISAEARVKDIEK------------- 587
Query: 446 EESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALL 505
E + E++ ETS + + +++L+ + E R +L E L++ LL
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKENELL 644
Query: 506 QEQVGGTLDAEREARTREQLQADLLRCQAKIE-----------DLEKLLVEKGQDSKWVE 554
Q+++ + EQ ++L R K++ LE L E Q ++
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ----LD 700
Query: 555 EKQLLIRTNQDLLE----KIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPA 610
E+ L +R N + L+ K+ +L++E +L++E + K ELL+ + E E
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 611 FNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV 670
+++ + LQ K + ++ L++ EE
Sbjct: 761 LDIE--------NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE---------- 802
Query: 671 LALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDL 730
L + K L+Q+E +L Q+ LEK+K ++ L ++ + + L++ +KI +L
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 731 EATLYTALQQEPG--RRAGEALSEGQRE----------DLQAAV----EKVRRQILRQSR 774
E T L +E G + + L E ++E D++ V + V ++ Q
Sbjct: 863 EKENKT-LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921
Query: 775 EFDSQILRERMELL-----------QQAQQRIRELEDKLEFQ-KRHLKELEEKFLFL 819
D + L +E + Q R + LE KLE K+ L+ EEK L
Sbjct: 922 NNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978
Score = 85.9 bits (211), Expect = 1e-16
Identities = 170/854 (19%), Positives = 364/854 (42%), Gaps = 155/854 (18%)
Query: 33 IQIEFQQEKSKVGKLRERLQE--------------AKLEREQEQRRHTAYISELK-AKLH 77
+ +E K+K+ +LR+ L+E ++E ++ Q+ + +S+ + A+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 78 EEKTKELQALREGLIRQHEQEAARTAKIKE--GELQRLQATLNVLRDGAADKVKTALLTE 135
+ EL ALRE +R + E + ++ KE +++ +A + L++ ++T + E
Sbjct: 309 RD---ELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 136 AREEARRAFDGERLRLQQEILELKAA-----------RKQAEEALSNCMQADKTKAADL- 183
+ E RA + L++E L+LKA RK+ EE + M + + +
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 184 -------------------RAAYQAHQDEVHR------IKRECE--------RDIRRLMD 210
A ++ EV+ +K E E ++R +D
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 211 EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGD 270
++G IL +EKE Q+L + E L+ ++VQ K++ ++ + ++L
Sbjct: 485 SVEGNASKILKMEKE-------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 271 MVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+ + + ++ ER ++ + + LN + L R+ + A E ++K
Sbjct: 538 LEKTIETLREN-SERQIKILEQENEHLNQTVSSLRQRSQISA-------------EARVK 583
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
+ ++NK +++ ++ + ++E + + + +E KEK L+ N+L
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE-----NELHHLE 638
Query: 391 DEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD 450
E E+ Q I +L + E+ + + L+ + + +T F +
Sbjct: 639 KENEL---------LQKKITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAR-EEADLRFCQLTREYQALQRAYALLQEQV 509
E+L + + D + E L A+ + + L +L E + L++ LL+
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 510 -----------GGTLDAEREARTREQLQADLLRCQAKIEDL--EKLLVEKGQDSKWVEEK 556
G ++ +R +T E + + +++++DL E ++K + + K
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 557 QL--LIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQ 614
+L L + N+ L ++ +LE ++ QL+ E + + Q E+ + LEE N++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEEN-------NVK 858
Query: 615 ITTF-PENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQV--AIIQAGTVL 671
I EN + + ++ ++E V + EL K+ N+E V A I T++
Sbjct: 859 IGNLEKENKTLSKEIGIYKESC--VRLKELEKE-----------NKELVKRATIDIKTLV 905
Query: 672 ALCEKWLKQIEGTEAALTQKM-LDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQD- 729
L E + +E TQ+M DLEK + G +E L + +Q+ D Y ++
Sbjct: 906 TLREDLV-----SEKLKTQQMNNDLEKLTHELEK-IGLNKERLLHDEQSTDDRYKLLESK 959
Query: 730 LEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQ 789
LE+TL +L+ + + A E + E+ +++R+++ + +++ R+ E +
Sbjct: 960 LESTLKKSLEIKEEKIAA---LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 790 QAQQRIRELEDKLE 803
Q+ I ++K E
Sbjct: 1017 QSSPPISGEDNKWE 1030
Score = 31.6 bits (70), Expect = 3.2
Identities = 33/184 (17%), Positives = 85/184 (46%), Gaps = 8/184 (4%)
Query: 15 ETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
ET+ +Q ++ L++ L + ++E + +++ KL+E+ Q+ + + +S+LK
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-TSTKLNNQCELLSQLKG 1317
Query: 75 KLHEEKTKELQALREGLIRQHE--QEAARTAKIKEGELQRLQATLNVLRDGAADKVKTAL 132
L EE L ++ +++ ++ + + E ++ LN LR +K++ +
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR-RQKEKLEEKI 1376
Query: 133 LTEAR----EEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
+ + + RR + L++++ I K ++ +++L+ + L+ +Q
Sbjct: 1377 MDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1436
Query: 189 AHQD 192
QD
Sbjct: 1437 DSQD 1440
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 103 bits (258), Expect = 5e-22
Identities = 134/593 (22%), Positives = 252/593 (42%), Gaps = 85/593 (14%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
++ + Q+ N EL K E Q + RE+LQ KL+RE++ A+ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ--REKLQREKLQREKDMLLAEAF--SL 1498
Query: 73 KAKLHE---------EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K +L E +K L+A + + Q ++ A AK+K+ +L+ L+A + +
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK-QLRDLEAKVKDQEEE 1557
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
++ T + E + + R + ER+R Q E+++ ++ EEA +C + K L
Sbjct: 1558 LDEQAGTIQMLE-QAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
Y+ Q +V R KRE E + L D++ +D EK L +T+ LL + +
Sbjct: 1616 EEEYEDKQ-KVLREKRELEGKLATLSDQVNRRD---FESEKRLRKDLKRTKALLADAQLM 1671
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
+ L ++R + K +L + V+ + E ++ L+I ++
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEES--EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE 363
LE++ + L E+NE+ R E + + L++K+K + L I ++ +++ +E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 364 NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK 423
E++EKL A S ++EFL +Q ++D + R+
Sbjct: 1790 KQELQEKLQALQS-----------------QVEFL------EQSMVDKSLVSRQE----- 1821
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
K +ET F+ V R + + +E+++ T EE
Sbjct: 1822 ---------AKIRELETRLEFERTQV------------KRLESLASRLKENMEKLT--EE 1858
Query: 484 ADLRFCQLTREYQ---ALQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDL 539
D R RE + LQR +E++G E EA R + +L+ DL +A + L
Sbjct: 1859 RDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSL 1918
Query: 540 E---KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKD 589
+ KL ++ D + E ++ N+DL+ ++ + +E++D D
Sbjct: 1919 QADLKLAFKRIGDLQAAIEDEMESDENEDLIN-----SEGDSDVDSELEDRVD 1966
Score = 83.6 bits (205), Expect = 7e-16
Identities = 160/786 (20%), Positives = 321/786 (40%), Gaps = 123/786 (15%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
VQ++ E++R K E QQ +SK+ K + E +L ++ + R ISEL ++L +
Sbjct: 1249 VQLSEEQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESR----ISELTSELTD 1300
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
E+ A + L+ E R K E++ LQ + L+ +V + EAR
Sbjct: 1301 ERNTGESASQ--LLDAETAERLRAEK----EMKELQTQYDALKKQM--EVMEMEVMEARL 1352
Query: 139 EARRAFDGE----------RLRLQQEILELKAARKQAEEALSNCMQAD-------KTKAA 181
+GE RL+ ++ + E+ +K+ ++ + ++ + + +
Sbjct: 1353 IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLG 1412
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRLMD-------------EIKGKDRVILALEKELGV 228
DL+A + Q + ++K++C+R L D E++ K R + EL
Sbjct: 1413 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQR---RFDSELSQ 1469
Query: 229 QAGQTQKLLLQKEALD-EQLVQVKEAERHHSSPKRELPPGIGDM-----------VELMG 276
+ Q+ LQ+E L E+ + + EA S K++L D+ EL
Sbjct: 1470 AHEEAQREKLQREKLQREKDMLLAEA----FSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 277 VQDQH-MDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK 335
+ Q DE + + + ++ +L + ++ E+ DE+ ++ + +++L+ +E+
Sbjct: 1526 ISSQESKDEASLAKVKKQLRDLEAKVKDQEEE----LDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 336 -----NKRMNKKNEDLLQSIQRMEEKIKNL---TRENVEMKEK-LSAQASLK-RHTSLND 385
+K M ++E++ ++ Q ++K+K + E E K+K L + L+ + +L+D
Sbjct: 1582 MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1641
Query: 386 LSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFD 445
RD + + LR + + ++ D L + L K+ P K+ + +
Sbjct: 1642 QVNRRDFESEKRLRKDLKRTKALLADAQLMLDHL--------KNSAPSKREIAQL----- 1688
Query: 446 EESVDSETLSETSYNTDRTDRTPATPEEDLDD--------ATAREEADLRFCQLTREYQA 497
L E+ + + E +++D A A+ + + +L RE
Sbjct: 1689 -----KNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 498 LQRAY--------ALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQD 549
+Q L+++ A R+ LQA L + ++L++ L
Sbjct: 1744 IQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQ 1803
Query: 550 SKWVE----EKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEER- 604
+++E +K L+ R + E RLE E Q+K A E +E E ++R
Sbjct: 1804 VEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI 1863
Query: 605 --ERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDIL-GDNGNLRNEEQ 661
E R N ++ + + +E EL L+ L N +L+ + +
Sbjct: 1864 AAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLK 1923
Query: 662 VAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKE-KDLFSRQKGYLEEELDYRKQAL 720
+A + G + A E ++ E + ++ D++ E +D K +L + K A
Sbjct: 1924 LAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAAS 1983
Query: 721 DQAYLK 726
D LK
Sbjct: 1984 DDGSLK 1989
Score = 68.6 bits (166), Expect = 2e-11
Identities = 119/582 (20%), Positives = 237/582 (40%), Gaps = 82/582 (14%)
Query: 289 RFQLKIAELNSVIRKLEDRNT------LLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
R + +I+EL S + ++RNT LL E E L+ +E +K L + + K+
Sbjct: 1286 RLESRISELTSELT--DERNTGESASQLLDAETAERLRAEKE----MKELQTQYDALKKQ 1339
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEK-LSAQASLKRHTSLNDLSLTRDEQEIEFLRLQ 401
E + ++ ME ++ N E+ + + LK ++ ++ T+ + EF
Sbjct: 1340 ME--VMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKL 1397
Query: 402 VLEQQHV------IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLS 455
+EQQ+ + DL + E R+ + K + + +T + + V + L
Sbjct: 1398 EVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELE 1457
Query: 456 ETSYNTD-------------RTDRTPATPEEDLDDATA------REEADLRFCQLTREYQ 496
+ D + R E+D+ A A EE D+ T++
Sbjct: 1458 KKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVV 1517
Query: 497 ALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEK 556
+L+ + Q + D A+ ++QL+ DL +AK++D E+ L E+ + +E+
Sbjct: 1518 SLEAELQDISSQE--SKDEASLAKVKKQLR-DL---EAKVKDQEEELDEQAGTIQMLEQA 1571
Query: 557 QLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQIT 616
+L + + + + + EME + E Q +L + V EE E + ++
Sbjct: 1572 KLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ-----KVL 1626
Query: 617 TFPENHSSALQLFCHQEGVKDVNVSELMKK---------------LDILGDNGNLRNEEQ 661
L Q +D + ++K LD L ++ + E
Sbjct: 1627 REKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKRE-- 1684
Query: 662 VAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALD 721
I Q L E A+ ++ DL + D ++ K LEE+L ++ +
Sbjct: 1685 --IAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN 1742
Query: 722 QAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQIL 781
+ ++++ + + +++ A + Q DLQA +E+ ++ +Q + Q L
Sbjct: 1743 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE--KQELQEKLQAL 1800
Query: 782 RERMELLQQA----------QQRIRELEDKLEFQKRHLKELE 813
+ ++E L+Q+ + +IRELE +LEF++ +K LE
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLE 1842
Score = 58.2 bits (139), Expect = 3e-08
Identities = 112/564 (19%), Positives = 229/564 (40%), Gaps = 77/564 (13%)
Query: 323 RETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE---------------NVEM 367
R + +++ L K ++ K+ +L + R+E +I LT E + E
Sbjct: 1257 RNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAET 1316
Query: 368 KEKLSAQASLKR-HTSLNDLSLTRDEQEIEFLRLQVLEQQHV---IDDLSLERERLLRSK 423
E+L A+ +K T + L + E+E + +++ + +DD E L+ +
Sbjct: 1317 AERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYE 1376
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPE-----EDLDDA 478
R + + KK + + F E+ ++ E ++ D + E + L
Sbjct: 1377 R-AVREVDFTKKRLQQEF----EDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKK 1431
Query: 479 TAREEADLRFCQL------TREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
R A+L+ +L R ++ ++ E +A+RE RE+LQ +
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 533 QAKIEDLEKLLVEKGQDSKWVEEKQLLIRTN-QDLLEKIYRLEMEENQLKNEMQD----A 587
A+ L++ L EK D +K + + QD+ + + E ++K +++D
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV 1551
Query: 588 KDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCH---------QEGVKDV 638
KDQ E L+ + ++ E+ +++ + HS ++ Q+ +K +
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 639 NVS---ELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWL-KQIEGTEAALT--QKM 692
V E K +L + L + Q EK L K ++ T+A L Q M
Sbjct: 1612 EVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLM 1671
Query: 693 LDLEKEKDLFSRQKGYLEEELDYRKQA--------------LDQAYLKIQDLEATLYTAL 738
LD K R+ L+ +L+ + ++ +L+I D+ A TAL
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDI-AKAKTAL 1730
Query: 739 QQEPGRRAGEALS-----EGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQ 793
+++ R E E +ED+ ++K + + + SR+ + + L++A +
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ--INDLQAQLEEANK 1788
Query: 794 RIRELEDKLEFQKRHLKELEEKFL 817
+EL++KL+ + ++ LE+ +
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMV 1812
Score = 54.3 bits (129), Expect = 5e-07
Identities = 107/500 (21%), Positives = 202/500 (40%), Gaps = 107/500 (21%)
Query: 333 VEKNKRMNKKNEDL-----------LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
V+KN + NK +D L +Q EE+I+N E +++ KL K
Sbjct: 1221 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLE-----KAEK 1275
Query: 382 SLNDLSLTRD--EQEIEFLRLQVLEQQHVIDD----LSLERERLLRSKRHRGKSLKPPKK 435
N+L L D E I L ++ ++++ + L E LR+++ K L+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEM-KELQTQYD 1334
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
+ + + E +++ + N + +DD A E L++ + RE
Sbjct: 1335 ALKKQMEVMEMEVMEARLIRAAEINGE------------VDDDDAGGEWRLKYERAVREV 1382
Query: 496 QALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEE 555
++ LQ++ L+ E++ + QL+ L QA E+ ++ L
Sbjct: 1383 DFTKKR---LQQEFEDKLEVEQQ--NKRQLERRLGDLQADSEESQRAL------------ 1425
Query: 556 KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQI 615
Q L +K RL E +QD K E + R ELE+++RR
Sbjct: 1426 --------QQLKKKCQRLTAE-------LQDTKLHLEGQQVRNHELEKKQRR-------- 1462
Query: 616 TTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCE 675
F S A H+E ++ E L+ E+ + + +A ++ +
Sbjct: 1463 --FDSELSQA-----HEEAQREKLQRE------------KLQREKDMLLAEAFSL----K 1499
Query: 676 KWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLY 735
+ L++ + A TQK++ LE E S Q+ E L K+ L K++D E
Sbjct: 1500 QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE---- 1555
Query: 736 TALQQEPGRRAGEA-LSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQR 794
+E +AG + E + L+ +E++R+ ++ D ++ R ++ +Q
Sbjct: 1556 ----EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 795 IRELEDKLEFQKRHLKELEE 814
+LE++ E +++ L+E E
Sbjct: 1612 EVQLEEEYEDKQKVLREKRE 1631
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 102 bits (255), Expect = 1e-21
Identities = 177/860 (20%), Positives = 360/860 (41%), Gaps = 111/860 (12%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYI 69
E+ + ET+ A EE+RA+L + + E ++ + E +E + E+++ A+I
Sbjct: 894 EQLQAETELFAEA-EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 70 SELKAKLHEE-----KTKELQALREGLIRQHEQE----------------------AART 102
+L+ +L EE K + + E I++ E+E A +
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 103 AKIKEGE-----LQRLQATLNVLRDGAADKVKTALLT-EAREEARRAFDGERLRLQQEIL 156
+++ E E L +++ V+ +++K T + E+A+R DGE LQ +I
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 157 ELKAARKQAEEALSNCMQADKTKAADLRAAYQA-HQDEVHRIKRECERDIRRLMDEIKGK 215
EL+A + + L+ + ++ + A R + H++ ++ RE + I L ++ + +
Sbjct: 1073 ELQAQIDELKLQLAK--KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 216 DRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELM 275
EK+ + + + L + E + +E EL + + +
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 276 GVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK 335
Q Q M +R + EL+ + + + L + L ++E ++K L +
Sbjct: 1191 EAQIQDMRQRHATALE----ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 336 NKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQE- 394
K + L +Q + K+ R VE+ EK S K L+++S +E E
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS-----KLQNELDNVSTLLEEAEK 1301
Query: 395 --IEF------LRLQVLEQQHVIDDLSLERERL---LRSKRHRGKSLKPPKKHVVETFFG 443
I+F L Q+ + Q ++ + + ++ L +R SL+ ++ E
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA--- 1358
Query: 444 FDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA 503
++++ + L+ S D T ++DL + EEA + + L+ A A
Sbjct: 1359 --RKNLEKQVLALQSQLAD----TKKKVDDDLGTIESLEEA---------KKKLLKDAEA 1403
Query: 504 LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTN 563
L Q E +A ++L+ R Q +++DL L + Q + +E+KQ
Sbjct: 1404 LSQR-------LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ------ 1450
Query: 564 QDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHS 623
+K +L EE + + +D+ E E RE+ + A L + E
Sbjct: 1451 ----KKFDQLLAEEKSISARYAEERDR--------AEAEAREKETKA--LSLARALEEAL 1496
Query: 624 SALQLFCHQEGVKDVNVSELMKKLDILGDN-GNLRNEEQVAIIQAGTVLALCEKWLKQIE 682
A + F Q ++ +LM D +G N L ++ Q + E+ +++
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 683 GTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEP 742
TE A + ++++ K F R +E+ + +K+ L + ++++LEA L +Q
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK---QVRELEAELEDERKQRA 1613
Query: 743 GRRAGEALSEGQREDLQAAVE---KVRRQILRQSREFDSQILRERMELLQQAQQRIRELE 799
A + E +DL+A +E K R ++++Q R+ +Q +++ L++A+ E+
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ-MKDYQRELEEARASRDEIF 1672
Query: 800 DKLEFQKRHLKELEEKFLFL 819
+ + ++ LK LE + L L
Sbjct: 1673 AQSKESEKKLKSLEAEILQL 1692
Score = 92.0 bits (227), Expect = 2e-18
Identities = 162/767 (21%), Positives = 326/767 (42%), Gaps = 130/767 (16%)
Query: 127 KVKTALLTEAREEARRAFDGERLRLQQ-------EILELKAARKQAEE---ALSNCMQAD 176
KVK L +EE +A D E L++++ E+ E++ +Q E L+ +QA+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 177 K---TKAADLRAAYQAHQDEVHRIKRECERDIRR-------LMDEIKGKDRVILALEKEL 226
+A ++RA A + E+ I + E + L +E K I LE++L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 227 GVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD-ER 285
+ G QKL L+K + ++ +++E E++ ++DQ+ +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEE--------------------EILLLEDQNSKFIK 999
Query: 286 DVRRFQLKIAELNSVIRKLEDRNTLLADERN-------ELLKRSRETEVQLKPLVEKNKR 338
+ + + +IAE +S + + E++ LA RN +L +R ++ E + L + ++
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 339 MNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDE--QEIE 396
++ + DL I ++ +I L + + +E+L Q +L R +D +L ++ + +
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEEL--QGALARG---DDETLHKNNALKVVR 1114
Query: 397 FLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSE 456
L+ Q+ E Q + R + + KR + L+ K + E+++D+ T ++
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL--------EDTLDT-TAAQ 1165
Query: 457 TSYNTDRTDRTPATPEEDLDDATAREEADLR---------FCQLTREYQALQRAYALLQE 507
T R ++ A ++ L++ T EA ++ +L+ + + +R A L++
Sbjct: 1166 QELRTKR-EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 508 QVGG----------------TLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQD-S 550
G + AE E + R++L A + AK+ + ++L VE + S
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHK-RKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 551 KWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPA 610
K E + ++ +K + + L++++QD ++ + + L L R R+
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 611 FNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV 670
+ E A + Q +++ KK+D D G + + E+
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD--DDLGTIESLEEAK------- 1394
Query: 671 LALCEKWLKQIEGTEAALTQKML---DLEKEKDLFSRQKGYLEEELDYRKQA---LDQAY 724
+K LK E L +K L LEK K+ ++ L +LD+++Q L++
Sbjct: 1395 ----KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450
Query: 725 LKIQDL---EATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ-- 779
K L E ++ +E R EA ++E ++ + + L EF+ Q
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEA---REKETKALSLARALEEALEAKEEFERQNK 1507
Query: 780 ILRERMELLQQAQQRI-----------RELEDKLEFQKRHLKELEEK 815
LR ME L ++ + R LE ++E + L+ELE++
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Score = 89.7 bits (221), Expect = 1e-17
Identities = 135/625 (21%), Positives = 268/625 (42%), Gaps = 76/625 (12%)
Query: 17 DAVQMANEELRAKLT-SIQI-EFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
D ++ EE R KL S +I + ++EK+ + + +E +EA+ E++ + +++ K
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 75 KLH---------EEKTKELQALREGLIRQHEQEAARTAKIK------EGELQRLQATLNV 119
K+ EE K+L E L ++ E++A K++ + EL L L+
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 120 LRDGAADKVKTA-----LLTEARE------EARRAFDGERLRLQQEILELKAARKQAEEA 168
R A++ K LL E + E R + E + + L L A ++A EA
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 169 LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGV 228
+ +K AD+ + +D+V + E E+ R L +++ + LE EL
Sbjct: 1499 KEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 229 QAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR 288
+L + +A+ Q + + + K+ L I + EL + +R +
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRELEAELEDERKQRALA 1615
Query: 289 RFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQ 348
K E++ ++ LE + R+E++K+ R+ + Q+K + + +++
Sbjct: 1616 VASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 349 SIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHV 408
+ E+K+K+L E ++++E+L++ +RH EQE + L ++
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHA----------EQERDELADEITNSASG 1723
Query: 409 IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTP 468
L E+ RL + + + +EE + E L++ T T +
Sbjct: 1724 KSALLDEKRRL--------------EARIAQLEEELEEEQSNMELLNDRFRKT--TLQVD 1767
Query: 469 ATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQAD 528
E + +A +++D QL R+ + L+ A LQ E E + + +A
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELK---AKLQ---------ELEGAVKSKFKAT 1815
Query: 529 LLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEE---NQLKNEMQ 585
+ +AKI LE+ L ++ ++ +L+ RT + L E ++E E +Q K +M+
Sbjct: 1816 ISALEAKIGQLEEQLEQEAKER--AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873
Query: 586 DAKDQNELLEFRVLELEERERRSPA 610
A + + L+ ++ E EE R+ A
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANA 1898
Score = 39.7 bits (91), Expect = 0.012
Identities = 40/166 (24%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K + ++ N+EL+AKL ++ + + K+ + L ++ + + + EQE +
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A + + E+K KE + Q E E + KE ++++ A + L+
Sbjct: 1837 RAA--ANKLVRRTEKKLKE-------IFMQVEDERRHADQYKE-QMEKANARMKQLK--- 1883
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALS 170
L EA EEA RA + R +LQ+E+ + A + +S
Sbjct: 1884 ------RQLEEAEEEATRA-NASRRKLQRELDDATEANEGLSREVS 1922
Score = 36.6 bits (83), Expect = 0.098
Identities = 49/269 (18%), Positives = 112/269 (41%), Gaps = 54/269 (20%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ--------- 60
E+ D + ++E KL S++ E Q + ++ + A+ ER++
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 61 --------EQRRHTAYISELKAKLHEEKTK--------------------ELQA------ 86
E+RR A I++L+ +L EE++ EL A
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 87 ----LREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--A 140
R+ L RQ+++ A+ +++ + +AT++ L + +++ L EA+E A
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL-EAKIGQLEEQLEQEAKERAAA 1840
Query: 141 RRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRI--- 197
+ +L++ ++++ R+ A++ M+ + L+ + ++E R
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQ-YKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 198 KRECERDIRRLMDEIKGKDRVILALEKEL 226
+R+ +R++ + +G R + L+ L
Sbjct: 1900 RRKLQRELDDATEANEGLSREVSTLKNRL 1928
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 102 bits (254), Expect = 1e-21
Identities = 205/924 (22%), Positives = 381/924 (41%), Gaps = 164/924 (17%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEF---QQEKSKVGKLRERLQE------AKLEREQ 60
E+ E +Q+ AK+ ++ E + +K+ K R+ L+E L E+
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 61 EQ--------RRHTAYISELKAKLHEEKT--KELQALREGLIRQ----HEQEAARTAKIK 106
E+ +H + ISEL+ +L +E+ +EL+ L+ L HEQ A A+I
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 107 EGELQ------RLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKA 160
E ++Q LQA L L D A K L + RE +G LQ+++ +A
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNA--LKKIRE-----LEGHISDLQEDLDSERA 1132
Query: 161 ARKQAEEA---LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
AR +AE+ L ++A KT+ D + Q+ R KRE E + +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKK--------- 1181
Query: 218 VILALEKELGVQAGQTQKLLLQK----EALDEQLVQVKEAERHHSSPKRELPPGIGDM-- 271
AL++E Q Q++ + E L EQL Q K A+ + K+ L D+
Sbjct: 1182 ---ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 272 -VELMGVQDQHMD------ERDVRRFQLKI-------AELNSVIRKLEDRNTLLADERNE 317
+ ++G Q ++ E V+ Q K AELN + KL++ + NE
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 318 -------LLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEK 370
L K QL+ E + ++ ++ ++++EE+ +L + + E+
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEE 1355
Query: 371 LSAQASLKRHTSLNDLSLT---------------------RDEQEIEFLRLQVLEQQHVI 409
+ A+ +L+RH S ++ L+ R ++EIE L Q E+
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 410 DDLSLERERL----------LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
D L + RL L ++R +L+ ++ FD+ + + +S S
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-------FDQLLAEEKNIS--SK 1466
Query: 460 NTDRTDRTPATPEED----LDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDA 515
D DR A E L A A EEA + L+R +L+ ++ + +
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1519
Query: 516 EREA-RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLE 574
+ + + +L+ + ++E+++ L E + + E+ +L + N L+ + +
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEG 634
++ +NE + + Q +L E+ +ER++R+ A + + LQ +G
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 635 VKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLD 694
++ + +L K + + + E + A + A ++ K+ + EA L Q D
Sbjct: 1640 -REEAIKQLRK---LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 695 L---EKEKDLFSRQKGYLEEELDYR---KQALDQAYLKIQDLEATLYTALQQEPGRRAGE 748
L E+ + +K L EEL + AL +++ A L L++E G E
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM--E 1753
Query: 749 ALSEGQREDLQAAV----------------EKVRRQILRQSREFDSQILRERMELLQQAQ 792
A+S+ R+ Q A E R+Q+ RQ++E S++ + + +
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1813
Query: 793 QRIRELEDKL-EFQKRHLKELEEK 815
I LE K+ + +++ +E EK
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREK 1837
Score = 94.0 bits (232), Expect = 5e-19
Identities = 185/888 (20%), Positives = 365/888 (41%), Gaps = 146/888 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRER------LQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1150 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1208 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRF--QLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1325 QEET---RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1489
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 DLDDAT-AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L+D A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1550 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1601
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 585 QDAK----------DQNEL----LEFRVLELEE----RERRSPAFNLQITTFPENHSSAL 626
+DA+ +NE LE +++L+E ER +L+ E +S+L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 627 Q---LFCHQEGVKDVNVSELMKKLDILGDNGNL-----------RNEEQVAIIQAGTVLA 672
++ + +++L ++L+ + GN+ + EQ++ + T +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSN-ELATERS 1778
Query: 673 LCEK-----------------WLKQIEG--------TEAALTQKMLDLEKEKDLFSRQKG 707
+K L ++EG T AAL K+ LE++ + +R+K
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 708 YLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRR 767
+ L + + L + L+++D R+ E E Q E A V++++R
Sbjct: 1839 AATKSLKQKDKKLKEILLQVED-------------ERKMAEQYKE-QAEKGNARVKQLKR 1884
Query: 768 QILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q L ++ E +I R +L Q+ + E + E R + L+ K
Sbjct: 1885 Q-LEEAEEESQRINANRRKL----QRELDEATESNEAMGREVNALKSK 1927
Score = 90.1 bits (222), Expect = 8e-18
Identities = 173/843 (20%), Positives = 351/843 (41%), Gaps = 129/843 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 900
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 943
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 944 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1000
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1001 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1109
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1168
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1169 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1225 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1282 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEET 1328
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ--------LKNEMQDAKDQNELLEFRVL 599
+ V K + ++ L+ EME Q L ++ D+K + + V
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKD--------------------VN 639
LEE ++R F +I + + + E K+ N
Sbjct: 1389 ALEEGKKR---FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 640 VSELMKKLD-ILGDNGNLRN--------------EEQVAIIQAGTVLALCEKWLKQIEGT 684
+ + +K D +L + N+ + E++ + L + +++E T
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 685 EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGR 744
L +M DL KD + LE+ + +++ ++++LE L +
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 745 RAGEALSEGQRE-DLQA---AVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELED 800
+GQ E DLQA E+ RRQ+ RQ E+++++ ER + A + ++LE
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK-KKLEG 1624
Query: 801 KLE 803
L+
Sbjct: 1625 DLK 1627
Score = 90.1 bits (222), Expect = 8e-18
Identities = 141/643 (21%), Positives = 265/643 (41%), Gaps = 83/643 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1319 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1376
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1432
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1602
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1715
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1716 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1770
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1771 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1829 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERR 607
+ E+ R+ +L+ E+ +A + NE + V L+ + RR
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 89.4 bits (220), Expect = 1e-17
Identities = 147/659 (22%), Positives = 276/659 (41%), Gaps = 95/659 (14%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1088
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1143
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1193
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1246
Query: 581 KNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQITTFPENHSSALQLFCHQEGVK 636
K E++ K + LE +V EL+ + ER N ++ S + EG
Sbjct: 1247 KQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 637 DVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLE 696
++ L D L EE + T L+Q+E +L Q LD E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK-------LRQLEEERNSL-QDQLDEE 1355
Query: 697 KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQRE 756
E K LE + L + K+QD +T+ EAL EG++
Sbjct: 1356 ME------AKQNLERHISTLNIQLSDSKKKLQDFASTV-------------EALEEGKKR 1396
Query: 757 DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q +E + +Q ++ +D + + + QQ + +L L+ Q++ + LE+K
Sbjct: 1397 -FQKEIENLTQQYEEKAAAYD-----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/506 (18%), Positives = 209/506 (41%), Gaps = 89/506 (17%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 844 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 895 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 940
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFC 489
L+ +K + + +E+ + E AR++ L
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEE--------------------------AARQKLQLEKV 974
Query: 490 QLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVE-KGQ 548
+ + L+ ++ +Q +E + E+ +DL A+ E+ K L + K +
Sbjct: 975 TAEAKIKKLEDEILVMDDQ---NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 549 DSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE----ER 604
+ E ++ ++ + +++ +L + +L+ + D +Q L+ ++ EL+ ++
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 605 ERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAI 664
E A ++ ++AL+ EG ++S+L + LD RN+ +
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEG----HISDLQEDLD---SERAARNKAEKQK 1141
Query: 665 IQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAY 724
G +++E + L + +++L +++ E+E+ K+ALD+
Sbjct: 1142 RDLG----------EELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDE-- 1185
Query: 725 LKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRER 784
E + A QE ++ +A+ E + Q K +Q+ E ++ L
Sbjct: 1186 ------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLK 810
+ +L QA+Q + + KLE Q + L+
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Score = 44.3 bits (103), Expect = 5e-04
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 39/363 (10%)
Query: 478 ATAREEADLRFCQLTREYQAL------QRAYALLQEQVGGTLDAEREARTREQLQA-DLL 530
A EE DL+ + +QA+ ++A+A Q+Q+ +R +L+
Sbjct: 776 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW 835
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
R K++ L ++ ++ + +E Q Q ++ LE + +QL E ++Q
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 591 NELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDIL 650
+ E EE R A ++ + L+ +E +E K +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE---EEEDRGQQLQAERKKMAQQM 952
Query: 651 GDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE 710
D EE+ A + E +K++E + + L KE+ L + L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 711 EEL-DYRKQALDQAYLK------IQDLEATLYTALQQEPGRRAGEALS---EG------- 753
L + ++A + LK I +LE L ++E R+ E L EG
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 754 QREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQ--AQQRIRELEDKLEFQKRHLKE 811
Q DLQA + +++ Q+ ++ E + + R E+ Q+ A ++IRELE H+ +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-------HISD 1122
Query: 812 LEE 814
L+E
Sbjct: 1123 LQE 1125
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1884
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1885 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1927
Score = 37.4 bits (85), Expect = 0.058
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1859 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1916 AMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 102 bits (254), Expect = 1e-21
Identities = 205/924 (22%), Positives = 381/924 (41%), Gaps = 164/924 (17%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEF---QQEKSKVGKLRERLQE------AKLEREQ 60
E+ E +Q+ AK+ ++ E + +K+ K R+ L+E L E+
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 61 EQ--------RRHTAYISELKAKLHEEKT--KELQALREGLIRQ----HEQEAARTAKIK 106
E+ +H + ISEL+ +L +E+ +EL+ L+ L HEQ A A+I
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 107 EGELQ------RLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKA 160
E ++Q LQA L L D A K L + RE +G LQ+++ +A
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNA--LKKIRE-----LEGHISDLQEDLDSERA 1139
Query: 161 ARKQAEEA---LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
AR +AE+ L ++A KT+ D + Q+ R KRE E + +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKK--------- 1188
Query: 218 VILALEKELGVQAGQTQKLLLQK----EALDEQLVQVKEAERHHSSPKRELPPGIGDM-- 271
AL++E Q Q++ + E L EQL Q K A+ + K+ L D+
Sbjct: 1189 ---ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 272 -VELMGVQDQHMD------ERDVRRFQLKI-------AELNSVIRKLEDRNTLLADERNE 317
+ ++G Q ++ E V+ Q K AELN + KL++ + NE
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 318 -------LLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEK 370
L K QL+ E + ++ ++ ++++EE+ +L + + E+
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEE 1362
Query: 371 LSAQASLKRHTSLNDLSLT---------------------RDEQEIEFLRLQVLEQQHVI 409
+ A+ +L+RH S ++ L+ R ++EIE L Q E+
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 410 DDLSLERERL----------LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
D L + RL L ++R +L+ ++ FD+ + + +S S
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-------FDQLLAEEKNIS--SK 1473
Query: 460 NTDRTDRTPATPEED----LDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDA 515
D DR A E L A A EEA + L+R +L+ ++ + +
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1526
Query: 516 EREA-RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLE 574
+ + + +L+ + ++E+++ L E + + E+ +L + N L+ + +
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEG 634
++ +NE + + Q +L E+ +ER++R+ A + + LQ +G
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 635 VKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLD 694
++ + +L K + + + E + A + A ++ K+ + EA L Q D
Sbjct: 1647 -REEAIKQLRK---LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 695 L---EKEKDLFSRQKGYLEEELDYR---KQALDQAYLKIQDLEATLYTALQQEPGRRAGE 748
L E+ + +K L EEL + AL +++ A L L++E G E
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM--E 1760
Query: 749 ALSEGQREDLQAAV----------------EKVRRQILRQSREFDSQILRERMELLQQAQ 792
A+S+ R+ Q A E R+Q+ RQ++E S++ + + +
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1820
Query: 793 QRIRELEDKL-EFQKRHLKELEEK 815
I LE K+ + +++ +E EK
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREK 1844
Score = 94.0 bits (232), Expect = 5e-19
Identities = 185/888 (20%), Positives = 365/888 (41%), Gaps = 146/888 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRER------LQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1157 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1215 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRF--QLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1332 QEET---RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1496
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 DLDDAT-AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L+D A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1557 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1608
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 585 QDAK----------DQNEL----LEFRVLELEE----RERRSPAFNLQITTFPENHSSAL 626
+DA+ +NE LE +++L+E ER +L+ E +S+L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 627 Q---LFCHQEGVKDVNVSELMKKLDILGDNGNL-----------RNEEQVAIIQAGTVLA 672
++ + +++L ++L+ + GN+ + EQ++ + T +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSN-ELATERS 1785
Query: 673 LCEK-----------------WLKQIEG--------TEAALTQKMLDLEKEKDLFSRQKG 707
+K L ++EG T AAL K+ LE++ + +R+K
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 708 YLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRR 767
+ L + + L + L+++D R+ E E Q E A V++++R
Sbjct: 1846 AATKSLKQKDKKLKEILLQVED-------------ERKMAEQYKE-QAEKGNARVKQLKR 1891
Query: 768 QILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q L ++ E +I R +L Q+ + E + E R + L+ K
Sbjct: 1892 Q-LEEAEEESQRINANRRKL----QRELDEATESNEAMGREVNALKSK 1934
Score = 90.1 bits (222), Expect = 8e-18
Identities = 173/843 (20%), Positives = 351/843 (41%), Gaps = 129/843 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 907
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 950
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 951 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1008 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1116
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1175
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1176 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1232 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1289 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEET 1335
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ--------LKNEMQDAKDQNELLEFRVL 599
+ V K + ++ L+ EME Q L ++ D+K + + V
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKD--------------------VN 639
LEE ++R F +I + + + E K+ N
Sbjct: 1396 ALEEGKKR---FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 640 VSELMKKLD-ILGDNGNLRN--------------EEQVAIIQAGTVLALCEKWLKQIEGT 684
+ + +K D +L + N+ + E++ + L + +++E T
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 685 EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGR 744
L +M DL KD + LE+ + +++ ++++LE L +
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 745 RAGEALSEGQRE-DLQA---AVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELED 800
+GQ E DLQA E+ RRQ+ RQ E+++++ ER + A + ++LE
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK-KKLEG 1631
Query: 801 KLE 803
L+
Sbjct: 1632 DLK 1634
Score = 90.1 bits (222), Expect = 8e-18
Identities = 141/643 (21%), Positives = 265/643 (41%), Gaps = 83/643 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1326 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1383
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1439
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1609
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1722
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1723 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1777
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1778 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1836 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERR 607
+ E+ R+ +L+ E+ +A + NE + V L+ + RR
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 89.4 bits (220), Expect = 1e-17
Identities = 147/659 (22%), Positives = 276/659 (41%), Gaps = 95/659 (14%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1095
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1150
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1200
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1253
Query: 581 KNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQITTFPENHSSALQLFCHQEGVK 636
K E++ K + LE +V EL+ + ER N ++ S + EG
Sbjct: 1254 KQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 637 DVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLE 696
++ L D L EE + T L+Q+E +L Q LD E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK-------LRQLEEERNSL-QDQLDEE 1362
Query: 697 KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQRE 756
E K LE + L + K+QD +T+ EAL EG++
Sbjct: 1363 ME------AKQNLERHISTLNIQLSDSKKKLQDFASTV-------------EALEEGKKR 1403
Query: 757 DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q +E + +Q ++ +D + + + QQ + +L L+ Q++ + LE+K
Sbjct: 1404 -FQKEIENLTQQYEEKAAAYD-----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/506 (18%), Positives = 209/506 (41%), Gaps = 89/506 (17%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 851 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 902 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 947
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFC 489
L+ +K + + +E+ + E AR++ L
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEE--------------------------AARQKLQLEKV 981
Query: 490 QLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVE-KGQ 548
+ + L+ ++ +Q +E + E+ +DL A+ E+ K L + K +
Sbjct: 982 TAEAKIKKLEDEILVMDDQ---NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 549 DSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE----ER 604
+ E ++ ++ + +++ +L + +L+ + D +Q L+ ++ EL+ ++
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 605 ERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAI 664
E A ++ ++AL+ EG ++S+L + LD RN+ +
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEG----HISDLQEDLD---SERAARNKAEKQK 1148
Query: 665 IQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAY 724
G +++E + L + +++L +++ E+E+ K+ALD+
Sbjct: 1149 RDLG----------EELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDE-- 1192
Query: 725 LKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRER 784
E + A QE ++ +A+ E + Q K +Q+ E ++ L
Sbjct: 1193 ------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLK 810
+ +L QA+Q + + KLE Q + L+
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Score = 44.3 bits (103), Expect = 5e-04
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 39/363 (10%)
Query: 478 ATAREEADLRFCQLTREYQAL------QRAYALLQEQVGGTLDAEREARTREQLQA-DLL 530
A EE DL+ + +QA+ ++A+A Q+Q+ +R +L+
Sbjct: 783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW 842
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
R K++ L ++ ++ + +E Q Q ++ LE + +QL E ++Q
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 591 NELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDIL 650
+ E EE R A ++ + L+ +E +E K +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE---EEEDRGQQLQAERKKMAQQM 959
Query: 651 GDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE 710
D EE+ A + E +K++E + + L KE+ L + L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 711 EEL-DYRKQALDQAYLK------IQDLEATLYTALQQEPGRRAGEALS---EG------- 753
L + ++A + LK I +LE L ++E R+ E L EG
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 754 QREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQ--AQQRIRELEDKLEFQKRHLKE 811
Q DLQA + +++ Q+ ++ E + + R E+ Q+ A ++IRELE H+ +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-------HISD 1129
Query: 812 LEE 814
L+E
Sbjct: 1130 LQE 1132
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1891
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1892 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1934
Score = 37.4 bits (85), Expect = 0.058
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1866 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1923 AMGREVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 102 bits (254), Expect = 1e-21
Identities = 205/924 (22%), Positives = 381/924 (41%), Gaps = 164/924 (17%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEF---QQEKSKVGKLRERLQE------AKLEREQ 60
E+ E +Q+ AK+ ++ E + +K+ K R+ L+E L E+
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 61 EQ--------RRHTAYISELKAKLHEEKT--KELQALREGLIRQ----HEQEAARTAKIK 106
E+ +H + ISEL+ +L +E+ +EL+ L+ L HEQ A A+I
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 107 EGELQ------RLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKA 160
E ++Q LQA L L D A K L + RE +G LQ+++ +A
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNA--LKKIRE-----LEGHISDLQEDLDSERA 1139
Query: 161 ARKQAEEA---LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
AR +AE+ L ++A KT+ D + Q+ R KRE E + +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKK--------- 1188
Query: 218 VILALEKELGVQAGQTQKLLLQK----EALDEQLVQVKEAERHHSSPKRELPPGIGDM-- 271
AL++E Q Q++ + E L EQL Q K A+ + K+ L D+
Sbjct: 1189 ---ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 272 -VELMGVQDQHMD------ERDVRRFQLKI-------AELNSVIRKLEDRNTLLADERNE 317
+ ++G Q ++ E V+ Q K AELN + KL++ + NE
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 318 -------LLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEK 370
L K QL+ E + ++ ++ ++++EE+ +L + + E+
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEE 1362
Query: 371 LSAQASLKRHTSLNDLSLT---------------------RDEQEIEFLRLQVLEQQHVI 409
+ A+ +L+RH S ++ L+ R ++EIE L Q E+
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 410 DDLSLERERL----------LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
D L + RL L ++R +L+ ++ FD+ + + +S S
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-------FDQLLAEEKNIS--SK 1473
Query: 460 NTDRTDRTPATPEED----LDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDA 515
D DR A E L A A EEA + L+R +L+ ++ + +
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1526
Query: 516 EREA-RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLE 574
+ + + +L+ + ++E+++ L E + + E+ +L + N L+ + +
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEG 634
++ +NE + + Q +L E+ +ER++R+ A + + LQ +G
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 635 VKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLD 694
++ + +L K + + + E + A + A ++ K+ + EA L Q D
Sbjct: 1647 -REEAIKQLRK---LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 695 L---EKEKDLFSRQKGYLEEELDYR---KQALDQAYLKIQDLEATLYTALQQEPGRRAGE 748
L E+ + +K L EEL + AL +++ A L L++E G E
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM--E 1760
Query: 749 ALSEGQREDLQAAV----------------EKVRRQILRQSREFDSQILRERMELLQQAQ 792
A+S+ R+ Q A E R+Q+ RQ++E S++ + + +
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1820
Query: 793 QRIRELEDKL-EFQKRHLKELEEK 815
I LE K+ + +++ +E EK
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREK 1844
Score = 94.0 bits (232), Expect = 5e-19
Identities = 185/888 (20%), Positives = 365/888 (41%), Gaps = 146/888 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRER------LQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1157 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1215 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRF--QLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1332 QEET---RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1496
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 DLDDAT-AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L+D A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1557 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1608
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 585 QDAK----------DQNEL----LEFRVLELEE----RERRSPAFNLQITTFPENHSSAL 626
+DA+ +NE LE +++L+E ER +L+ E +S+L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 627 Q---LFCHQEGVKDVNVSELMKKLDILGDNGNL-----------RNEEQVAIIQAGTVLA 672
++ + +++L ++L+ + GN+ + EQ++ + T +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSN-ELATERS 1785
Query: 673 LCEK-----------------WLKQIEG--------TEAALTQKMLDLEKEKDLFSRQKG 707
+K L ++EG T AAL K+ LE++ + +R+K
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 708 YLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRR 767
+ L + + L + L+++D R+ E E Q E A V++++R
Sbjct: 1846 AATKSLKQKDKKLKEILLQVED-------------ERKMAEQYKE-QAEKGNARVKQLKR 1891
Query: 768 QILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q L ++ E +I R +L Q+ + E + E R + L+ K
Sbjct: 1892 Q-LEEAEEESQRINANRRKL----QRELDEATESNEAMGREVNALKSK 1934
Score = 90.1 bits (222), Expect = 8e-18
Identities = 173/843 (20%), Positives = 351/843 (41%), Gaps = 129/843 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 907
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 950
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 951 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1008 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1116
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1175
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1176 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1232 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1289 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEET 1335
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ--------LKNEMQDAKDQNELLEFRVL 599
+ V K + ++ L+ EME Q L ++ D+K + + V
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKD--------------------VN 639
LEE ++R F +I + + + E K+ N
Sbjct: 1396 ALEEGKKR---FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 640 VSELMKKLD-ILGDNGNLRN--------------EEQVAIIQAGTVLALCEKWLKQIEGT 684
+ + +K D +L + N+ + E++ + L + +++E T
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 685 EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGR 744
L +M DL KD + LE+ + +++ ++++LE L +
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 745 RAGEALSEGQRE-DLQA---AVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELED 800
+GQ E DLQA E+ RRQ+ RQ E+++++ ER + A + ++LE
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK-KKLEG 1631
Query: 801 KLE 803
L+
Sbjct: 1632 DLK 1634
Score = 89.7 bits (221), Expect = 1e-17
Identities = 141/645 (21%), Positives = 265/645 (41%), Gaps = 83/645 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1326 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1383
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1439
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1609
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1722
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1723 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1777
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1778 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1836 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSP 609
+ E+ R+ +L+ E+ +A + NE + V L+ + R P
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPP 1939
Score = 89.4 bits (220), Expect = 1e-17
Identities = 147/659 (22%), Positives = 276/659 (41%), Gaps = 95/659 (14%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1095
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1150
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1200
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1253
Query: 581 KNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQITTFPENHSSALQLFCHQEGVK 636
K E++ K + LE +V EL+ + ER N ++ S + EG
Sbjct: 1254 KQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 637 DVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLE 696
++ L D L EE + T L+Q+E +L Q LD E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK-------LRQLEEERNSL-QDQLDEE 1362
Query: 697 KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQRE 756
E K LE + L + K+QD +T+ EAL EG++
Sbjct: 1363 ME------AKQNLERHISTLNIQLSDSKKKLQDFASTV-------------EALEEGKKR 1403
Query: 757 DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q +E + +Q ++ +D + + + QQ + +L L+ Q++ + LE+K
Sbjct: 1404 -FQKEIENLTQQYEEKAAAYD-----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/506 (18%), Positives = 209/506 (41%), Gaps = 89/506 (17%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 851 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 902 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 947
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFC 489
L+ +K + + +E+ + E AR++ L
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEE--------------------------AARQKLQLEKV 981
Query: 490 QLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVE-KGQ 548
+ + L+ ++ +Q +E + E+ +DL A+ E+ K L + K +
Sbjct: 982 TAEAKIKKLEDEILVMDDQ---NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 549 DSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE----ER 604
+ E ++ ++ + +++ +L + +L+ + D +Q L+ ++ EL+ ++
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 605 ERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAI 664
E A ++ ++AL+ EG ++S+L + LD RN+ +
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEG----HISDLQEDLD---SERAARNKAEKQK 1148
Query: 665 IQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAY 724
G +++E + L + +++L +++ E+E+ K+ALD+
Sbjct: 1149 RDLG----------EELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDE-- 1192
Query: 725 LKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRER 784
E + A QE ++ +A+ E + Q K +Q+ E ++ L
Sbjct: 1193 ------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLK 810
+ +L QA+Q + + KLE Q + L+
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Score = 44.3 bits (103), Expect = 5e-04
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 39/363 (10%)
Query: 478 ATAREEADLRFCQLTREYQAL------QRAYALLQEQVGGTLDAEREARTREQLQA-DLL 530
A EE DL+ + +QA+ ++A+A Q+Q+ +R +L+
Sbjct: 783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW 842
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
R K++ L ++ ++ + +E Q Q ++ LE + +QL E ++Q
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 591 NELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDIL 650
+ E EE R A ++ + L+ +E +E K +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE---EEEDRGQQLQAERKKMAQQM 959
Query: 651 GDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE 710
D EE+ A + E +K++E + + L KE+ L + L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 711 EEL-DYRKQALDQAYLK------IQDLEATLYTALQQEPGRRAGEALS---EG------- 753
L + ++A + LK I +LE L ++E R+ E L EG
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 754 QREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQ--AQQRIRELEDKLEFQKRHLKE 811
Q DLQA + +++ Q+ ++ E + + R E+ Q+ A ++IRELE H+ +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-------HISD 1129
Query: 812 LEE 814
L+E
Sbjct: 1130 LQE 1132
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1891
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1892 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1934
Score = 37.4 bits (85), Expect = 0.058
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1866 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1923 AMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 102 bits (254), Expect = 1e-21
Identities = 205/924 (22%), Positives = 381/924 (41%), Gaps = 164/924 (17%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEF---QQEKSKVGKLRERLQE------AKLEREQ 60
E+ E +Q+ AK+ ++ E + +K+ K R+ L+E L E+
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 61 EQ--------RRHTAYISELKAKLHEEKT--KELQALREGLIRQ----HEQEAARTAKIK 106
E+ +H + ISEL+ +L +E+ +EL+ L+ L HEQ A A+I
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 107 EGELQ------RLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKA 160
E ++Q LQA L L D A K L + RE +G LQ+++ +A
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNA--LKKIRE-----LEGHISDLQEDLDSERA 1132
Query: 161 ARKQAEEA---LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
AR +AE+ L ++A KT+ D + Q+ R KRE E + +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKK--------- 1181
Query: 218 VILALEKELGVQAGQTQKLLLQK----EALDEQLVQVKEAERHHSSPKRELPPGIGDM-- 271
AL++E Q Q++ + E L EQL Q K A+ + K+ L D+
Sbjct: 1182 ---ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 272 -VELMGVQDQHMD------ERDVRRFQLKI-------AELNSVIRKLEDRNTLLADERNE 317
+ ++G Q ++ E V+ Q K AELN + KL++ + NE
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 318 -------LLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEK 370
L K QL+ E + ++ ++ ++++EE+ +L + + E+
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEE 1355
Query: 371 LSAQASLKRHTSLNDLSLT---------------------RDEQEIEFLRLQVLEQQHVI 409
+ A+ +L+RH S ++ L+ R ++EIE L Q E+
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 410 DDLSLERERL----------LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
D L + RL L ++R +L+ ++ FD+ + + +S S
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-------FDQLLAEEKNIS--SK 1466
Query: 460 NTDRTDRTPATPEED----LDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDA 515
D DR A E L A A EEA + L+R +L+ ++ + +
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1519
Query: 516 EREA-RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLE 574
+ + + +L+ + ++E+++ L E + + E+ +L + N L+ + +
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEG 634
++ +NE + + Q +L E+ +ER++R+ A + + LQ +G
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 635 VKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLD 694
++ + +L K + + + E + A + A ++ K+ + EA L Q D
Sbjct: 1640 -REEAIKQLRK---LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 695 L---EKEKDLFSRQKGYLEEELDYR---KQALDQAYLKIQDLEATLYTALQQEPGRRAGE 748
L E+ + +K L EEL + AL +++ A L L++E G E
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM--E 1753
Query: 749 ALSEGQREDLQAAV----------------EKVRRQILRQSREFDSQILRERMELLQQAQ 792
A+S+ R+ Q A E R+Q+ RQ++E S++ + + +
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1813
Query: 793 QRIRELEDKL-EFQKRHLKELEEK 815
I LE K+ + +++ +E EK
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREK 1837
Score = 94.0 bits (232), Expect = 5e-19
Identities = 185/888 (20%), Positives = 365/888 (41%), Gaps = 146/888 (16%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRER------LQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1150 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1208 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRF--QLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1325 QEET---RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1489
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 DLDDAT-AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L+D A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1550 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1601
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 585 QDAK----------DQNEL----LEFRVLELEE----RERRSPAFNLQITTFPENHSSAL 626
+DA+ +NE LE +++L+E ER +L+ E +S+L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 627 Q---LFCHQEGVKDVNVSELMKKLDILGDNGNL-----------RNEEQVAIIQAGTVLA 672
++ + +++L ++L+ + GN+ + EQ++ + T +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSN-ELATERS 1778
Query: 673 LCEK-----------------WLKQIEG--------TEAALTQKMLDLEKEKDLFSRQKG 707
+K L ++EG T AAL K+ LE++ + +R+K
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 708 YLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRR 767
+ L + + L + L+++D R+ E E Q E A V++++R
Sbjct: 1839 AATKSLKQKDKKLKEILLQVED-------------ERKMAEQYKE-QAEKGNARVKQLKR 1884
Query: 768 QILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q L ++ E +I R +L Q+ + E + E R + L+ K
Sbjct: 1885 Q-LEEAEEESQRINANRRKL----QRELDEATESNEAMGREVNALKSK 1927
Score = 90.1 bits (222), Expect = 8e-18
Identities = 173/843 (20%), Positives = 351/843 (41%), Gaps = 129/843 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 900
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 943
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 944 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1000
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1001 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1109
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1168
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1169 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1225 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1282 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEET 1328
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ--------LKNEMQDAKDQNELLEFRVL 599
+ V K + ++ L+ EME Q L ++ D+K + + V
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKD--------------------VN 639
LEE ++R F +I + + + E K+ N
Sbjct: 1389 ALEEGKKR---FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 640 VSELMKKLD-ILGDNGNLRN--------------EEQVAIIQAGTVLALCEKWLKQIEGT 684
+ + +K D +L + N+ + E++ + L + +++E T
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 685 EAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGR 744
L +M DL KD + LE+ + +++ ++++LE L +
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 745 RAGEALSEGQRE-DLQA---AVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELED 800
+GQ E DLQA E+ RRQ+ RQ E+++++ ER + A + ++LE
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK-KKLEG 1624
Query: 801 KLE 803
L+
Sbjct: 1625 DLK 1627
Score = 89.7 bits (221), Expect = 1e-17
Identities = 141/645 (21%), Positives = 265/645 (41%), Gaps = 83/645 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1319 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1376
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1432
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1602
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1715
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1716 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1770
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1771 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1829 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSP 609
+ E+ R+ +L+ E+ +A + NE + V L+ + R P
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPP 1932
Score = 89.4 bits (220), Expect = 1e-17
Identities = 147/659 (22%), Positives = 276/659 (41%), Gaps = 95/659 (14%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1088
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1143
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1193
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1246
Query: 581 KNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQITTFPENHSSALQLFCHQEGVK 636
K E++ K + LE +V EL+ + ER N ++ S + EG
Sbjct: 1247 KQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 637 DVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLE 696
++ L D L EE + T L+Q+E +L Q LD E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK-------LRQLEEERNSL-QDQLDEE 1355
Query: 697 KEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQRE 756
E K LE + L + K+QD +T+ EAL EG++
Sbjct: 1356 ME------AKQNLERHISTLNIQLSDSKKKLQDFASTV-------------EALEEGKKR 1396
Query: 757 DLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
Q +E + +Q ++ +D + + + QQ + +L L+ Q++ + LE+K
Sbjct: 1397 -FQKEIENLTQQYEEKAAAYD-----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 59.3 bits (142), Expect = 1e-08
Identities = 96/506 (18%), Positives = 209/506 (41%), Gaps = 89/506 (17%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 844 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 895 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 940
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFC 489
L+ +K + + +E+ + E AR++ L
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEE--------------------------AARQKLQLEKV 974
Query: 490 QLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVE-KGQ 548
+ + L+ ++ +Q +E + E+ +DL A+ E+ K L + K +
Sbjct: 975 TAEAKIKKLEDEILVMDDQ---NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 549 DSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE----ER 604
+ E ++ ++ + +++ +L + +L+ + D +Q L+ ++ EL+ ++
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 605 ERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAI 664
E A ++ ++AL+ EG ++S+L + LD RN+ +
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEG----HISDLQEDLD---SERAARNKAEKQK 1141
Query: 665 IQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAY 724
G +++E + L + +++L +++ E+E+ K+ALD+
Sbjct: 1142 RDLG----------EELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDE-- 1185
Query: 725 LKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRER 784
E + A QE ++ +A+ E + Q K +Q+ E ++ L
Sbjct: 1186 ------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLK 810
+ +L QA+Q + + KLE Q + L+
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Score = 44.3 bits (103), Expect = 5e-04
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 39/363 (10%)
Query: 478 ATAREEADLRFCQLTREYQAL------QRAYALLQEQVGGTLDAEREARTREQLQA-DLL 530
A EE DL+ + +QA+ ++A+A Q+Q+ +R +L+
Sbjct: 776 AHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW 835
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
R K++ L ++ ++ + +E Q Q ++ LE + +QL E ++Q
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 591 NELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDIL 650
+ E EE R A ++ + L+ +E +E K +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE---EEEDRGQQLQAERKKMAQQM 952
Query: 651 GDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLE 710
D EE+ A + E +K++E + + L KE+ L + L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 711 EEL-DYRKQALDQAYLK------IQDLEATLYTALQQEPGRRAGEALS---EG------- 753
L + ++A + LK I +LE L ++E R+ E L EG
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 754 QREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQ--AQQRIRELEDKLEFQKRHLKE 811
Q DLQA + +++ Q+ ++ E + + R E+ Q+ A ++IRELE H+ +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-------HISD 1122
Query: 812 LEE 814
L+E
Sbjct: 1123 LQE 1125
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1884
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1885 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1927
Score = 37.4 bits (85), Expect = 0.058
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1859 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1916 AMGREVNALKSKL 1928
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 102 bits (253), Expect = 2e-21
Identities = 147/719 (20%), Positives = 303/719 (42%), Gaps = 71/719 (9%)
Query: 38 QQEKSKVGK--LRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQH 95
QQ + K L L+E + + +R K L EK + L++ G + +
Sbjct: 548 QQTNEETAKQILYNYLKEGSTDNDDATKR--------KVNLVFEKIQTLKSRAAGSAQGN 599
Query: 96 EQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI 155
Q T+++K+ Q+ + T+ V +++ L E + + + ER+R E
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVA------ELQRQLQLEVKNQQNIKEERERMRANLE- 652
Query: 156 LELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECER---DIRRLMDEI 212
EL++ + E S Q + +LR + +E+ ++K E E+ +IR L D++
Sbjct: 653 -ELRSQHNEKVEENSTLQQRLEESEGELRK----NLEELFQVKMEREQHQTEIRDLQDQL 707
Query: 213 KGK-DRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDM 271
D + A E + ++LL K+ L + L+ +E E +REL G +
Sbjct: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
Query: 272 VELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKP 331
E + DQ MD+ ++ ++ L + + +LA N + TE+++K
Sbjct: 768 KEEVSSHDQEMDKLK-EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826
Query: 332 LVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENV-------------------------E 366
L E+N+++ ++E+L + + +++ +I++L + E
Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKE 886
Query: 367 MKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHR 426
KE +SA+ +L+ +L++ QE + L ++ E+ + L + + + H
Sbjct: 887 EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHL 946
Query: 427 GKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADL 486
GK+++ +K + + ++ E ++ ++ R A + L + T E
Sbjct: 947 GKTIEKLQKEMADIVEASRTSTL--ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS- 1003
Query: 487 RFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLR-------CQAKIEDL 539
+LT +Q L++E++ A+ EA T+ QL L+ ++ ++D
Sbjct: 1004 ---RLTA--MKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD 1058
Query: 540 EKLLVEKGQDSKWVEEKQL-LIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELLEFR 597
LV++ +D E +L R N DLL E+I R + QL+NE+ + + LE
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECD 1118
Query: 598 VLELEERER--RSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGN 655
+ LE + + +S +L+ + +Q+ ++D SE + ++ N
Sbjct: 1119 KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR 1178
Query: 656 LRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELD 714
L + + ++Q Q+ A+ +++ + E+E D K L+ EL+
Sbjct: 1179 LERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
Score = 86.7 bits (213), Expect = 8e-17
Identities = 136/654 (20%), Positives = 290/654 (44%), Gaps = 101/654 (15%)
Query: 31 TSIQIEFQQEKSK----VGKLRERLQ-EAKLER--EQEQRRHTAYISELKAKLHEEKTKE 83
TS + ++KSK V +L+ +LQ E K ++ ++E+ R A + EL+++ H EK +E
Sbjct: 606 TSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ-HNEKVEE 664
Query: 84 LQALR------EGLIRQHEQEAARTAKIKEG---ELQRLQATLNVLRDGAADKVKTALLT 134
L+ EG +R++ +E + +E E++ LQ L+ + D ++ +A +
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD----ELDSAKRS 720
Query: 135 EAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEV 194
E RE+ A E L+ +Q++ +L A+++ E+ L + L+ +H E+
Sbjct: 721 EDREKG--ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 195 HRIKRECERDIRRLMDEIKGKDRVILALEKELGV----QAGQTQKLLLQKEALDEQLVQV 250
++K + + +++ L + ++ + + L QAG ++ L +E ++ +
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 251 KEAERHHSSPKRELPPGIGDMV--------------------------ELMGVQDQHMDE 284
+E ER + +R++ GD E V + E
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE 898
Query: 285 RDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNE 344
++ Q +++ ++L ++ ++++ +L + E E + L + +++ K+
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 345 DLLQSIQ--------RMEEKIKNLTRENVEMKEKL---SAQASLKRHTSL---NDLSLTR 390
D++++ + +++E + RE EM+ +L + +A R T++ +++ L
Sbjct: 959 DIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
Query: 391 DE-------QEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFG 443
+E Q+ + Q+LEQ + DL E E K R + +K + V +
Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQ--TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 444 FDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQR--- 500
+EE +S+ LSE + ++ E L + AR++ + L R+ + L+
Sbjct: 1077 LEEERNNSDLLSERISRS--REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRII 1134
Query: 501 ----AYALLQEQVGGTLDA---------EREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+Y +E + ++A E E R R LQ R + K+++L + V+
Sbjct: 1135 HLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV-MQVDDE 1193
Query: 548 QDSKWVEEKQLLIRTN------QDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
S ++ QL +R ++ E+I RLE + +L+ E+++ D NE L+
Sbjct: 1194 HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
Score = 69.3 bits (168), Expect = 1e-11
Identities = 121/564 (21%), Positives = 236/564 (41%), Gaps = 56/564 (9%)
Query: 288 RRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLL 347
R+ QL++ ++ + E L + R++ ++ E + L E + K E+L
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 348 QSIQRMEE---KIKNLTRENVEMKEKL-SAQASLKRHTSLNDLSLTRDEQEIEFLRLQVL 403
Q E+ +I++L + EM ++L SA+ S R L + +Q+++ L +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
Query: 404 EQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDR 463
EQ+ DL +RER L + + G + H E ++ + + L E+ +
Sbjct: 748 EQE----DLLRKRERELTALK--GALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK 801
Query: 464 TDRTPATPEEDLDDATAREEADLRFCQLTREY-----QALQRAYALLQEQVGGTLDAERE 518
A+ + A E ++ Q E + L+R A LQ Q+ E +
Sbjct: 802 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAK 861
Query: 519 ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE-KIYRLEMEE 577
A+ L + + +I LE+ LV ++ K + + + + + + E+
Sbjct: 862 AKET------LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ 915
Query: 578 NQLKNEMQDAKDQNELLEFRVLELEERE----RRSPAFNLQITTFPE-NHSSALQLFCHQ 632
QL ++++ +Q E L E+E + ++ E + +S L+L
Sbjct: 916 KQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQL 975
Query: 633 EGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIE-GTEAALTQK 691
+ K+ N EL + L + + ++ ++ + L E+ L+ + + ALT++
Sbjct: 976 DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
Query: 692 MLDLEKEKDLFSR--QKGYLEEELDYRKQALDQAYLKIQDLEATLY-----TALQQEPGR 744
L + KDL K +L+++ R + + Q K+ LE L + L E
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDD---RSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
Query: 745 RAGEALSEGQREDLQAAVEKVRRQIL--------RQSREFDSQILR-------ERMELLQ 789
R+ E + + + E LQ E+ RQ L RQ+++ S+I+ + L+
Sbjct: 1093 RSREQMEQLRNELLQ---ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVV 1149
Query: 790 QAQQRIRELEDKLEFQKRHLKELE 813
Q + RI ELED+LE ++R L+
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQ 1173
Score = 47.0 bits (110), Expect = 7e-05
Identities = 108/508 (21%), Positives = 212/508 (41%), Gaps = 72/508 (14%)
Query: 317 ELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQAS 376
+LLK +E Q K N E + + K+ NL E ++ + +A ++
Sbjct: 538 DLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKV-NLVFEKIQTLKSRAAGSA 596
Query: 377 LKRHTSLNDLSLTRD--EQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPK 434
+ + N S +D EQ+ + L ++V E Q + L ++ ++ ++ +R R ++
Sbjct: 597 QGNNQACNSTSEVKDLLEQKSK-LTIEVAELQRQLQ-LEVKNQQNIKEERERMRA----- 649
Query: 435 KHVVETFFGFDE-ESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTR 493
+E S +E + E S R + + ++L++ Q+
Sbjct: 650 --------NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEE----------LFQVKM 691
Query: 494 EYQALQRAYALLQEQVG---GTLDAEREARTREQ--LQADLLRCQAKIEDLEKLLVEKGQ 548
E + Q LQ+Q+ LD+ + + RE+ L +LL QAK +DL+ LL+ K
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL--QAK-QDLQDLLIAKE- 747
Query: 549 DSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRS 608
E++ LL + ++L L+ E + EM K+Q + E + L E
Sbjct: 748 -----EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA-ELQALRESVEEATK 801
Query: 609 PAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRN-----EEQVA 663
N+++ N S +D +E+ KL + +N L+ E +VA
Sbjct: 802 ---NVEVLASRSNTSE-----------QDQAGTEMRVKL-LQEENEKLQGRSEELERRVA 846
Query: 664 IIQAGTV-----LALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQ 718
+Q A ++ LK+ EG L + ++ KE+ + LE EL+ +
Sbjct: 847 QLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQG 906
Query: 719 ALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQ---ILRQSRE 775
L Q + + L L +Q+ R + E +R L +EK++++ I+ SR
Sbjct: 907 NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
Query: 776 FDSQILRERMELLQQAQQRIRELEDKLE 803
++ + E ++ ++ + E++ +L+
Sbjct: 967 STLELQNQLDEYKEKNRRELAEMQRQLK 994
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 99.8 bits (247), Expect = 9e-21
Identities = 174/837 (20%), Positives = 354/837 (42%), Gaps = 122/837 (14%)
Query: 22 ANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKT 81
A ++L+ +L+ ++ ++Q K++ ++LQ+ + E+EQ + + I++L +KL E +
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEF----KQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 82 KELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
+ +A G +++ Q ++ KE ++ LQ L+ L + +KV + + + +
Sbjct: 429 QLGEA--HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 142 RAFDGERLRLQQEIL-ELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRE 200
+ E+ LQQ +L+ A+ E+ L D+ K +L A Q ++ + +++E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKE 545
Query: 201 CERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSP 260
E D+ + +G+ V+ L+++ L EQ+ Q+ E ++ S
Sbjct: 546 RE-DLYAKIQAGEGETAVLNQLQEK--------------NHTLQEQVTQLTEKLKNQSES 590
Query: 261 KRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADE---RNE 317
++ + D V+ + +R V + + ELNS + + +++ + L + + E
Sbjct: 591 HKQAQENLHDQVQEQKAHLRAAQDR-VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 318 LL------KRSRETEVQ------LKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENV 365
LL K ++ ++Q L +K + +NK L Q ++++K ++ ++
Sbjct: 650 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 366 EMKEKLSAQASLKRHTSLND---LSLTRDEQEIEFLR---LQVLEQQHVID-DLSLERER 418
+KE SL++ T + L D E++ + LQ L+QQ ++ DL L
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 419 LLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA 478
L K L+ K+ V T ++S E++ + + + E L
Sbjct: 770 L-------SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 479 TAREEADLR---------FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADL 529
T + +L ++ E +AL + +++++ D+ + +++ + + +
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS--EFEKEN 880
Query: 530 LRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKD 589
+ +A I DLEK E + QL ++ L E+ +LK ++ K+
Sbjct: 881 QKGKAAILDLEKTCKEL--------KHQLQVQMENTL--------KEQKELKKSLEKEKE 924
Query: 590 QNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDI 649
+ L+ + ++E+ ++ T +N QL Q + ++ S KK I
Sbjct: 925 ASHQLKLELNSMQEQLIQAQ------NTLKQNEKEEQQL---QGNINELKQSSEQKKKQI 975
Query: 650 LGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYL 709
G L+ +A++Q + E L+Q LTQ +L EK+ S +
Sbjct: 976 EALQGELK----IAVLQKTEL----ENKLQQ------QLTQAAQELAAEKEKISVLQNNY 1021
Query: 710 EEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQ- 768
E+ + KQ Y + +L AT ++ + E LS Q EDL + ++ Q
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLAT------RQDLKSVEEKLSLAQ-EDLISNRNQIGNQN 1074
Query: 769 -----------ILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEE 814
L Q Q L+ER + LQ Q+ E +L +K L E+EE
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Score = 81.6 bits (200), Expect = 3e-15
Identities = 176/910 (19%), Positives = 358/910 (39%), Gaps = 144/910 (15%)
Query: 8 KGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA 67
K K E A Q+A E + I+ ++ +E+S LRE ++ +E +
Sbjct: 155 KQMKDLFEQKAAQLATE-----IADIKSKYDEERS----LREAAEQKVTRLTEELNKEAT 205
Query: 68 YISELKAKLHE-----------EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
I +LK +L + ++ ++Q L + + + E+E+ K+K+ E ++LQ+
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE---KLKD-ECKKLQSQ 261
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ ++++ L +E A + E +L+ + EL + E L Q D
Sbjct: 262 Y-ASSEATISQLRSELAKGPQEVA--VYVQELQKLKSSVNELTQKNQTLTENLLKKEQ-D 317
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKL 236
TK + + + + + D ++L + + + + EL + TQKL
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 237 LLQKEALDE-------------QLVQVKEAERHHS---------------SPKRELPPGI 268
KE L E QL Q +E + H +R+L
Sbjct: 378 ---KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 269 GDMVELMGVQDQHM--DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETE 326
G + E + + + E+ V QLK++ L +++ +T L + ++ ++ +E +
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 327 VQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL------TRENVEMKEK------LSAQ 374
+ K + E +L+ I ++KI+NL ++EN+ + EK Q
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 375 ASLKRHTSLNDL---------SLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRH 425
A LN L +T+ ++++ + Q + D E++ LR+ +
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
Query: 426 RGKSLKPPKKHV-------------------VETFFGFDEESVDSETLSETSYNTDRTDR 466
R SL+ + +T E+ + ++ + D
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
Query: 467 TPATPEED-------LDDATAREEADLRFC-QLTREYQALQRAYALLQ---EQVGGTL-- 513
+++ LD TA+ + C QL + + Y L+ E++ G +
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 514 ---DAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQLLIRTNQDLLEK 569
D+ ++EQ DL + + DLE E SK +E EK+++ T DL +K
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL---SKQLEMEKEIVSSTRLDLQKK 791
Query: 570 IYRLEMEENQLKNEMQDAKDQNELL--EFRVLELEERERRSPAFNLQITTFPENHSSALQ 627
LE +K ++ +++ ++L +F L E + + N TT E LQ
Sbjct: 792 SEALE----SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE-----LQ 842
Query: 628 LFCHQEGVKDVNVSELMKKLDILGDN-GNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEA 686
++ +S + KL + D+ N ++E + + + EK K++
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL----- 897
Query: 687 ALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRA 746
+ L ++ E L +++ L++ L+ K+A Q L++ ++ L A
Sbjct: 898 ---KHQLQVQMENTL--KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 747 GEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQK 806
E +G +L+ + E+ ++QI E +L ++ EL + QQ++ + +L +K
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL-QKTELENKLQQQLTQAAQELAAEK 1011
Query: 807 RHLKELEEKF 816
+ L+ +
Sbjct: 1012 EKISVLQNNY 1021
Score = 75.1 bits (183), Expect = 2e-13
Identities = 134/677 (19%), Positives = 283/677 (41%), Gaps = 85/677 (12%)
Query: 191 QDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQA------GQTQKLLLQKEALD 244
+D+V +++E + L +E + + LEK G+Q G + ++L+
Sbjct: 82 RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLE 141
Query: 245 EQLVQVKEAERHHSSPKRELPPGIGDMV-ELMGVQDQHMDERDVRRF-QLKIAELNSVIR 302
+QL + + + K + E+ ++ ++ +ER +R + K+ L +
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN 201
Query: 303 KLEDRNTLLADERNELLKRS--RETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
K T++ D + ELL+R + V K LV+ M +++ +R EK+K+
Sbjct: 202 K---EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM----DNMTLERERESEKLKD- 253
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
E K+ S AS + S L + QE+ ++ + + +++L+ + + L
Sbjct: 254 -----ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 421 RSKRHRGKSL-KPPKKHVVETFFGFDEESVDSETLSETSYNTD----RTDRTPATPEEDL 475
+ + + K +KH +EESV + + T + D + + E L
Sbjct: 309 ENLLKKEQDYTKLEEKH--------NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 476 --------DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQA 527
+ A ++ ++ +YQ L+ + LQ+Q E + + QLQ+
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ------REEKEQHGLQLQS 414
Query: 528 DLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDA 587
++ + +K+ + E+ L E K E++QL D +++ L+++ ++L+ ++++
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLK--EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK 472
Query: 588 KDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKL 647
+ L+ ++ + +++ + A T + L+ Q G KD + L L
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 648 DILGDNGNLRNEEQ---VAIIQAGTVLALCEKWLKQIEGT-EAALTQKMLDLEKEKDLFS 703
+N +L +E+ A IQAG L++ T + +TQ L+ + +
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 704 RQKGYLEEELDYRKQALDQAYLKIQDLEAT---LYTALQQEPGR---------------R 745
+ + L +++ +K L A ++ LE + L + L + +
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 746 AGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQ 805
+ EA QR DLQ ++ + + + +E + ++ Q Q +L+DK E
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELN--------KITTQLDQVTAKLQDKQEHC 704
Query: 806 KR---HLKELEEKFLFL 819
+ HLKE +EK+L L
Sbjct: 705 SQLESHLKEYKEKYLSL 721
Score = 72.8 bits (177), Expect = 1e-12
Identities = 163/802 (20%), Positives = 334/802 (41%), Gaps = 146/802 (18%)
Query: 9 GEKPEMETDAVQMANEELRAKLTSI--QIEFQQEKSKVGK--LRERLQEAKLEREQEQRR 64
GE + +Q N L+ ++T + +++ Q E K + L +++QE K Q R
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 65 HTAY---ISELKAKLHEEKTK------ELQALREGLIRQHEQEAARTAKI---------- 105
+ ++EL ++L+E K K +++A E L+ + A+ A +
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 106 ---KEGELQRLQATLNVLRDGAADKVKTALLTEAR-----------EEARRAFDGERLRL 151
K+ EL ++ L+ + DK + E+ E+ +G+ +L
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 152 QQEILELKAARKQAEE-----------------ALSNCMQADKTKAADLRAAYQAHQDEV 194
+ + LE+KA+++QA + LS ++ +K + R Q + +
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 195 HRIKREC----------ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALD 244
IK++ ++D L E K + L + + QK+ ++KEAL
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHE---ELNNRIQTTVTELQKVKMEKEALM 852
Query: 245 EQLVQVKEA--------ERHHSSPKRELPPGIGDMVELMGV--QDQHMDERDVRRFQLKI 294
+L VK+ + S ++E G +++L + +H + + +
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
EL + K ++ + L E N + ++ + + LK ++ +++ +L QS ++ +
Sbjct: 913 KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972
Query: 355 EKIKNLTRE-NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLS 413
++I+ L E + + +K + L++ + L ++++I L+ + Q L
Sbjct: 973 KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
Query: 414 LE---RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPAT 470
+ RE L + R KS VE +E + S N ++ + T
Sbjct: 1033 SDFYGRESELLATRQDLKS--------VEEKLSLAQEDLISNR--NQIGNQNKLIQELKT 1082
Query: 471 PEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQV---GGTLDAEREARTREQLQA 527
+ L+ +A++E L+ + + Q +Q+ +L ++++ L E + R++ +
Sbjct: 1083 AKATLEQDSAKKEQQLQ--ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 528 DLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIR--------------------TNQDLL 567
L + K LE + + + + KQLLI+ NQ +L
Sbjct: 1141 TKLNEELKSHKLESIK----EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 568 EKIYRLEMEENQLKNEM--QDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
+ +++ EE +LK E ++AK +E+ E + + +++ E +QIT EN +
Sbjct: 1197 KD--QVKKEEEELKKEFIEKEAKLHSEIKE-KEVGMKKHEENEAKLTMQITALNENLGTV 1253
Query: 626 LQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV-------LALCEKWL 678
+ + + VSEL K+ D +LR E +A+++A TV AL E+ L
Sbjct: 1254 KKEWQSSQR----RVSELEKQTD------DLRGE--IAVLEA-TVQNNQDERRALLERCL 1300
Query: 679 KQIEGTEAALTQKMLDLEKEKD 700
K EG L K+L+L+++ D
Sbjct: 1301 KG-EGEIEKLQTKVLELQRKLD 1321
Score = 65.9 bits (159), Expect = 2e-10
Identities = 103/504 (20%), Positives = 211/504 (41%), Gaps = 99/504 (19%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ--EQRRHTA 67
+K +ME +A+ ++ KL+ + + KS+ K ++ + A L+ E+ ++ +H
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
Query: 68 YIS---------ELKAKLHEEKTK------ELQALREGLIRQHEQEAARTAKIKEGELQR 112
+ ELK L +EK EL +++E LI +A T K E E Q+
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI-----QAQNTLKQNEKEEQQ 956
Query: 113 LQATLNVLRDGAADKVKT--ALLTEAREEARRAFDGERLRLQQEILELK---AARKQAEE 167
LQ +N L+ + K K AL E + + + E +LQQ++ + AA K+
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN-KLQQQLTQAAQELAAEKEKIS 1015
Query: 168 ALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELG 227
L N + + L++ + + E+ ++ D++ + +++ +++ ++G
Sbjct: 1016 VLQNNYEKSQETFKQLQSDFYGRESELLATRQ----DLKSVEEKLSLAQEDLISNRNQIG 1071
Query: 228 -----VQAGQTQKLLLQKEA------LDEQLVQVKEAERHHSSPKRELPPGIGDMVELMG 276
+Q +T K L++++ L E+ +++ ++ S ++EL + E+
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Query: 277 VQDQHMDERDVRRFQLKIAELNSV--IRKLEDRNTLLADERNELLKRS------------ 322
++ + E +LK +L S+ I L+D LL ++ EL ++
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191
Query: 323 ----------RETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLS 372
+E E K +EK +++ + ++ +++ EE LT + + E L
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251
Query: 373 A-----QASLKRHTSL----NDLS-----------------------LTRDEQEIEFLRL 400
Q+S +R + L +DL + E EIE L+
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1311
Query: 401 QVLEQQHVIDDLSLERERLLRSKR 424
+VLE Q +D+ + + L R +
Sbjct: 1312 KVLELQRKLDNTTAAVQELGRENQ 1335
Score = 41.6 bits (96), Expect = 0.003
Identities = 81/452 (17%), Positives = 185/452 (40%), Gaps = 57/452 (12%)
Query: 380 HTSLNDLSLTRDE-----QEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPK 434
H ++L+L RD+ QE++ L+ + E++ ++L E E+ ++G + K
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEK------YQGLQQQEAK 125
Query: 435 KHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTRE 494
+ T + +S++ + + N + ++ AT + ++ +
Sbjct: 126 PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
Query: 495 YQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE 554
+A ++ L E++ +EA + L+ +LL+ + IED+ L
Sbjct: 186 REAAEQKVTRLTEELN------KEATVIQDLKTELLQ-RPGIEDVAVL------------ 226
Query: 555 EKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQ 614
K+ L++ + E E +LK+E + + Q E + +L + P +
Sbjct: 227 -KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ---E 282
Query: 615 ITTFPENHSSALQLFCHQEGVKDVNVSE-LMKKLDILGDNGNLRNEEQVAIIQAGTVLAL 673
+ + + L+ ++ K+ ++E L+KK NEE V+ L
Sbjct: 283 VAVYVQELQK-LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Query: 674 ----CEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQD 729
C++ ++ +E +L + ++L +KG ++L K+ L + K Q
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVELS--------EKGEATQKL---KEELSEVETKYQH 390
Query: 730 LEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQI------LRQSREFDSQILRE 783
L+A QQ + + + L + + + RQ+ L++ R+ S+ L +
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD 450
Query: 784 RMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
+ + + Q ++ LE++L+ + + EL+ +
Sbjct: 451 KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 98.2 bits (243), Expect = 3e-20
Identities = 168/851 (19%), Positives = 355/851 (41%), Gaps = 94/851 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K K + + D + +LR + T++ Q G +RL+E +++R +E
Sbjct: 1054 QKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKET 1113
Query: 63 RRHTAY---ISELKAKLHEE-----KTKELQALREGLIRQH---EQEAARTAKIKEGELQ 111
H AY + KA + E K EL+ + L +Q E+E + + E EL+
Sbjct: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
Query: 112 RLQATL------NVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQA 165
+ Q + + + A + + L T RE + A + E R++Q +E +A R
Sbjct: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVRE--KEAAERELERVRQLTIEAEAKRAAV 1231
Query: 166 EEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKD-------RV 218
EE L N + + R + H + E+ +LM+E++ K ++
Sbjct: 1232 EENLLN-FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
Query: 219 ILALEKELGVQAGQTQKLLLQKEALD----EQLVQVKEAERHHSSPKRELPPGIGDMVEL 274
I +EK+L Q +K L +K+ ++ ++ +++ R ++ P + +
Sbjct: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRA-V 1349
Query: 275 MGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE 334
G+Q +H D++ + ++ EL + RK E L E N L +E + + L +
Sbjct: 1350 TGLQQEH-DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
Query: 335 KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQE 394
K N L ++R ++ K +++ E+ +L+ Q + K ++ + S + +
Sbjct: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN-QTTGKAEEAMQEASDLKKIKR 1467
Query: 395 IEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETL 454
L L+ L H L E +R+ R+ K++ +H+ F +E + E L
Sbjct: 1468 NYQLELESL--NHEKGKLQREVDRITRAHAVAEKNI----QHLNSQIHSFRDEK-ELERL 1520
Query: 455 SETSYNTDR-TDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTL 513
+D ++ + E+ L + A +E + + +L E + +L+++V
Sbjct: 1521 QICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV---- 1576
Query: 514 DAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRL 573
E TR+ + L+ + + E E +++EK Q + ++ L
Sbjct: 1577 ----EELTRQNNETKLMMQRIQAES-ENIVLEK-----------------QTIQQRCEAL 1614
Query: 574 EMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQE 633
+++ + K+++ + NE L + ++ +R+ + +N S + C Q+
Sbjct: 1615 KIQADGFKDQL---RSTNEHLHKQTKTEQDFQRKIKCLEEDLAK-SQNLVSEFKQKCDQQ 1670
Query: 634 GVKDVNVSELMKKL--DILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQK 691
+ N + ++ L ++ R EQ +Q V L + LK+++ T +
Sbjct: 1671 NIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNR-LKKVQDELHLKTIE 1729
Query: 692 MLDLEKEKDLFSRQKGYLEEEL-DYRK---QALDQAYLKIQDLEATL--YTALQQEPGRR 745
++ LF + G ++ ++RK + ++ + D+ + +LQQE R
Sbjct: 1730 EQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRA 1789
Query: 746 AGEA-LSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEF 804
A L E ++L+ +++ R Q +++ + Q+ ++LED+L
Sbjct: 1790 QENAKLCETNIKELERQLQQYREQ------------MQQGQHMEANHYQKCQKLEDELIA 1837
Query: 805 QKRHLKELEEK 815
QKR ++ L++K
Sbjct: 1838 QKREVENLKQK 1848
Score = 34.3 bits (77), Expect = 0.49
Identities = 50/226 (22%), Positives = 100/226 (44%), Gaps = 20/226 (8%)
Query: 14 METDAVQMAN--EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAY 68
+E D + N E + K I Q K +V L L +K E+ EQ+ + A
Sbjct: 1649 LEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ 1708
Query: 69 ISELKAKL-------HEEKTKELQALREGLIRQHEQ-EAARTAKIKEGELQRLQATLNVL 120
+ EL +L H + +E R+ ++ Q E + ++A+ ++++L + V+
Sbjct: 1709 VQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMES-KVI 1767
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
+ ++ ++ ++E RA + +L + I EL+ +Q E MQ +
Sbjct: 1768 TENDISGIRLDFVS-LQQENSRAQENAKL-CETNIKELERQLQQYREQ----MQQGQHME 1821
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226
A+ Q +DE+ KRE E +++ +IK + ++ L+ E+
Sbjct: 1822 ANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEI 1867
Score = 32.0 bits (71), Expect = 2.4
Identities = 96/520 (18%), Positives = 211/520 (40%), Gaps = 77/520 (14%)
Query: 340 NKKNEDLLQSIQRMEEKIKNLTREN-VEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFL 398
NK+ DL I++ + + L E+ + MK +S H +N++ R
Sbjct: 619 NKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW------HYLINEIDRIRASNVASIK 672
Query: 399 RLQVLEQQHVIDDLSLERERLLRSKRHR----GKSLKPPKK--HVVETFFGFDEESVDSE 452
+ E Q V+ +L E L + G + +K +V + ++ +S + E
Sbjct: 673 TMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE 732
Query: 453 TLSETSYNT----------------DRTDRTPATPEE--DLDDATAREEADLRFCQLTRE 494
E+ YN DR R TP E DL ++ R E
Sbjct: 733 EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR----------ITE 782
Query: 495 YQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIED-LEKLLVEKGQDSKWV 553
+ L++ L++ +G + E ++ + + ++++ L+ + S ++
Sbjct: 783 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842
Query: 554 EEKQ---LLIRTNQ--DLLEKIYRLEM--------EENQLKNEMQDAKD-QNELLEFRVL 599
++ + L+++ Q + L K+Y ++ ++N ++N + K ++E+ E R +
Sbjct: 843 DKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQV 902
Query: 600 --ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLR 657
LE+ +++ A + ++ F L H+E K + E + + + DN LR
Sbjct: 903 FHALEDELQKAKAISDEM--FKTYKERDLDFDWHKE--KADQLVERWQNVHVQIDN-RLR 957
Query: 658 NEEQV--AIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDY 715
+ E + ++ + W++Q+E T+ + + + K Q+ L E++
Sbjct: 958 DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEM 1017
Query: 716 RKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSRE 775
++ +D+ + AT+ Q R A+ + Q++ V+R+ ++ S +
Sbjct: 1018 KQSKMDECQKYAEQYSATVKDYELQTMTYR---AMVDSQQK------SPVKRRRMQSSAD 1068
Query: 776 FDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
I++E M+L + + + ++F LK LEE+
Sbjct: 1069 L---IIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE 1105
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 96.3 bits (238), Expect = 1e-19
Identities = 176/829 (21%), Positives = 368/829 (44%), Gaps = 132/829 (15%)
Query: 25 ELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKEL 84
+L+AK+ Q+ Q + K+ +L+ R++E + E E E HT L+AK+ ++++
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE---HT-----LRAKIEKQRSDLA 1144
Query: 85 QALREGLIRQHEQEAARTAKI-----KEGELQRL-----------QATLNVLRDGAADKV 128
+ L E R E A +A+I +E E Q++ +AT LR AD V
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204
Query: 129 KTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
A L E + +R + +L++E ELK + ++ SN K+K+ ++ +
Sbjct: 1205 --AELGEQIDNLQRV----KQKLEKEKSELKM---EIDDMASNIEALSKSKS-NIERTCR 1254
Query: 189 AHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ----KEALD 244
+D+ IK + E+ + + D K R + EL + + + L+ Q K+AL
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKAR-LQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 245 EQLVQVKEAERHHSSPKRELPPGI-GDMVELMGVQDQHMDERDVR-RFQLKIAELNSVIR 302
+QL ++K + K + + + +++Q+ +E++ + Q +++ NS +
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 303 KLEDRNTLLADERNELLKRSRETEVQ-LKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLT 361
+ + A +R E L+ +++ Q L+ E + N K L ++ QR++ ++++L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 362 RENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLR 421
R+ ++ +A A+L + D L +Q+++ + ++ Q LS E ++
Sbjct: 1434 RD---LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN 1490
Query: 422 SKRH---RGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA 478
+ + ++L+ K++ E E S +E ++ET N ++T E+
Sbjct: 1491 AYEEVVDQLETLRRENKNLQE------EISDLTEQIAETGKNLQEAEKTKKLVEQ----- 1539
Query: 479 TAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIED 538
E++DL+ + E+V G+L+ E R QL+ ++ +
Sbjct: 1540 ---EKSDLQ----------------VALEEVEGSLEHEESKILRVQLELSQVK-----SE 1575
Query: 539 LEKLLVEKGQDSKWVEEK-QLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFR 597
L++ ++EK ++ + ++ Q Q +L+ R + +LK +M+ D NE+
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG--DLNEM---- 1629
Query: 598 VLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLR 657
++L R+ + T Q +KD S+L D L N +L+
Sbjct: 1630 EIQLGHSNRQMAETQKHLRTV-------------QGQLKD---SQLHLD-DALRSNEDLK 1672
Query: 658 NEEQVAIIQA--GTVLALCEKW---LKQIEGTEAALTQKMLDLEKEKDLFSRQ------- 705
EQ+AI++ G +L E+ L+Q E T Q++LD L Q
Sbjct: 1673 --EQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 706 KGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKV 765
K LE ++ + ++ + + ++ E A+ + A E E +D A +E++
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAIT-DAAMMAEELKKE---QDTSAHLERM 1786
Query: 766 RRQILRQSREFDSQI-------LRERMELLQQAQQRIRELEDKLEFQKR 807
++ + + ++ ++ L+ + +Q+ + R+RELE++L+ +++
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQK 1835
Score = 92.0 bits (227), Expect = 2e-18
Identities = 161/807 (19%), Positives = 323/807 (40%), Gaps = 126/807 (15%)
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
E KE+ ++E R E+ A A+ KE E + +++L++ +++ TE
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELE----EKMVSLLQEKNDLQLQVQSETENLM 903
Query: 139 EARRAFDG---ERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE-- 193
+A +G ++ L+ ++ EL R + EE +++ + A K D ++ + D+
Sbjct: 904 DAEERCEGLIKSKILLEAKVKEL-TERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 194 -----VHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQ------------- 234
V + K E ++ L +E+ + I L KE +Q Q
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 235 -------KLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVE-LMGVQ-DQHMDER 285
KL Q + L+ L Q K+ KR+L + E +M ++ D+ E
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEE 1082
Query: 286 DVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNED 345
+++ + ++++L + I + + + EL R E E +++ ++ K+ D
Sbjct: 1083 KLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD 1142
Query: 346 LLQSIQRMEEKIKNL---TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQ- 401
L + ++ + E+++ T +EM +K A+ K L + +L + + Q
Sbjct: 1143 LARELEEISERLEEASGATSAQIEMNKKREAEFQ-KMRRDLEEATLQHEATAATLRKKQA 1201
Query: 402 --VLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
V E ID+L +++L + K E D+ + + E LS++
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKS--------------ELKMEIDDMASNIEALSKSKS 1247
Query: 460 NTDRTDRT--------PATPEE------DLDDATAR------------EEADLRFCQLTR 493
N +RT RT A E+ DL+ AR EE + QLT+
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 494 EYQALQRAYALLQEQVGGTLDAER---EARTREQLQADLLRCQAKIEDLEKLLVEKGQDS 550
QAL + L+ Q+ A+ A + DLLR Q + E K +++
Sbjct: 1308 SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367
Query: 551 KWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPA 610
E Q + D +++ LE + +L +Q+A++ E + LE+ ++R
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG 1427
Query: 611 FNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTV 670
+ E +A ++ D ++E +KLD ++
Sbjct: 1428 EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD-----------------ESQAE 1470
Query: 671 LALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDL 730
L +K + + + ++ + + R+ L+EE+ + + + +Q+
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA 1530
Query: 731 EATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQ- 789
E T + L E ++ DLQ A+E+V + + +S+ILR ++EL Q
Sbjct: 1531 EKT--------------KKLVEQEKSDLQVALEEVEGSLEHE----ESKILRVQLELSQV 1572
Query: 790 --QAQQRIRELEDKLEFQKRHLKELEE 814
+ +++ E ++++E KR+ + E
Sbjct: 1573 KSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Score = 77.0 bits (188), Expect = 7e-14
Identities = 154/719 (21%), Positives = 284/719 (39%), Gaps = 139/719 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELK 73
M+ +Q N EL ++ + Q L ++L+E K + E+E + A L+
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 74 AKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALL 133
+ H + LRE + EQEA + ELQR + N K +T +
Sbjct: 1339 SSRH-----DCDLLREQY--EEEQEA-------KAELQRALSKANSEVAQWRTKYETDAI 1384
Query: 134 --TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQ 191
TE EEA++ +L Q + E A + E A S C +KTK Q Q
Sbjct: 1385 QRTEELEEAKK-------KLAQRLQE---AEENTETANSKCASLEKTK--------QRLQ 1426
Query: 192 DEVHRIKRECERD---IRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLV 248
EV + R+ ER L + + D+V+ +++L + + + +L +L
Sbjct: 1427 GEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELF 1486
Query: 249 QVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRN 308
+++ A + D +E + +++++ E ++ +IAE +++ E
Sbjct: 1487 KMRNAYEE-----------VVDQLETLRRENKNLQE-EISDLTEQIAETGKNLQEAEKTK 1534
Query: 309 TLLADERNELLKRSRETEVQLK----PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTREN 364
L+ E+++L E E L+ ++ +++ +L + + +E+I+ L R +
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 365 VEMKEKLSAQASLKRHTSLNDLSLTR------DEQEIEF---LRLQVLEQQHV------I 409
E L + + + + L L + +E EI+ R Q+H+ +
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL 1654
Query: 410 DDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPA 469
D L + LRS + L +VE + E L E ++T+RT
Sbjct: 1655 KDSQLHLDDALRSNEDLKEQLA-----IVER-----RNGLLLEELEEMKVALEQTERTRR 1704
Query: 470 TPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADL 529
E++L DA+ R + LL Q ++ T+++L+AD+
Sbjct: 1705 LSEQELLDASDRVQ--------------------LLHSQNTSLIN------TKKKLEADI 1738
Query: 530 LRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEME-----ENQLKNEM 584
+CQA++E+ Q+S+ EEK T+ ++ + + E + E KN
Sbjct: 1739 AQCQAEVEN-------SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 585 QDAKD------------------QNELLEFRVLELEER---ERRSPAFNLQITTFPENHS 623
Q KD Q + LE RV ELE E++ A L+ E
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851
Query: 624 SALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIE 682
+ ++ + + +L+ KL + + EE A QA T L+ C + ++E
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE--AEEQANTQLSRCRRVQHELE 1908
Score = 60.8 bits (146), Expect = 5e-09
Identities = 69/385 (17%), Positives = 161/385 (41%), Gaps = 32/385 (8%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYI 69
++ E V+ +L+ L ++ + E+SK+ +++ L + K E +++ I
Sbjct: 1528 QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEI 1587
Query: 70 SELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVK 129
+LK + + + LQ++ + IR +A R K EG+L ++ L A+ K
Sbjct: 1588 EQLK-RNSQRAAEALQSVLDAEIRS-RNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645
Query: 130 TALLTEAREEARRAFDGERLR------------------LQQEILELKAARKQAEEALSN 171
+ + + + + LR L +E+ E+K A +Q E
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERT-RR 1704
Query: 172 CMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAG 231
+ + A+D + + K++ E DI + E++ + E+
Sbjct: 1705 LSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE------- 1757
Query: 232 QTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQ 291
+ +K + + E+L + ++ H K+ L + D+ + ++ ++ +
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL----DEAEQLALKGGK 1813
Query: 292 LKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ 351
+I +L + +R+LE+ + E LK + + E ++K + + + +K L +
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVD 1873
Query: 352 RMEEKIKNLTRENVEMKEKLSAQAS 376
+++ K+K+ R+ E +E+ + Q S
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLS 1898
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 95.9 bits (237), Expect = 1e-19
Identities = 182/844 (21%), Positives = 368/844 (43%), Gaps = 85/844 (10%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAK 75
+Q +EL+A++ ++ E + E++ KV KLR L +LE E+ + ++ +
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR-ELEEISERLEEAGGATSVQIE 1162
Query: 76 LHEEKTKELQALREGLIR---QHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTAL 132
+++++ E Q +R L QHE AA K + L ++ L+ +VK L
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ-----RVKQKL 1217
Query: 133 LTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQD 192
E + E + D ++Q I++ KA ++ L + M ++KA + + +
Sbjct: 1218 EKE-KSEFKLELDDVTSNMEQ-IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1275
Query: 193 EVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKE 252
+ +++ E ++ R +DE K+ +I L + + TQ+L K L+E+ V+ K
Sbjct: 1276 QRAKLQTE-NGELSRQLDE---KEALISQLTRG---KLTYTQQLEDLKRQLEEE-VKAKN 1327
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR-RFQLKIAELNSVIRKLEDRNTLL 311
A H R + +++Q+ +E + + Q +++ NS + + +
Sbjct: 1328 ALAHALQSARH---------DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Query: 312 ADERNELLKRSRETEVQ-LKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEK 370
A +R E L+ +++ Q L+ E + +N K L ++ R++ +I++L V+++
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERS 1435
Query: 371 LSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSL 430
+A A+L + D L +Q+ E + ++ Q LS E +L + + L
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495
Query: 431 ---KPPKKHVVETFFGFDEESVDS-ETLSETSYNTDRTDRTPATPEEDLDDATAREE--- 483
K K++ E E+ S +T+ E + + + L++A A E
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 484 -----ADLRFCQLT-----------REYQALQRAYALLQEQVGGTLDAEREART-----R 522
A L F Q+ E + +R + + + + +LDAE +R +
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE------EKQL--LIRTNQDLLEKIYRLE 574
++++ DL + ++ ++ E + K ++ + QL +R N DL E I +E
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1675
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEG 634
N L+ E+++ + E E R +L E+E + +Q+ HS L +Q+
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE-RSRKLAEQELIETSERVQLL-----HSQNTSLI-NQKK 1728
Query: 635 VKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLD 694
D ++S+L +++ RN E+ A +A T A+ + LK+ + T A L + +
Sbjct: 1729 KMDADLSQLQTEVEEAVQE--CRNAEEKAK-KAITDAAMMAEELKKEQDTSAHLERMKKN 1785
Query: 695 LEKE-KDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEG 753
+E+ KDL R + L K+ L + ++++LE L ++ G SE
Sbjct: 1786 MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 754 QREDLQAAVEKVRRQILRQSREFDSQILRER--MELLQQAQQRIRELEDKLEFQKRHLKE 811
+ ++L E+ R+ +LR D L+ + ++A+++ K + L E
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Query: 812 LEEK 815
EE+
Sbjct: 1906 AEER 1909
Score = 89.4 bits (220), Expect = 1e-17
Identities = 173/866 (19%), Positives = 361/866 (41%), Gaps = 129/866 (14%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRR------HTAYISELKAKL 76
N EL AK ++ E + K + L L + + E+ + + A + E+ AKL
Sbjct: 933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Query: 77 HEEKTKELQALREGLIR-QHEQEAART---AKIK-EGELQRLQATLNVLRDGAADKVKTA 131
+EK +A ++ L Q E++ T AK+K E ++ L+ +L + KV+
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK-----KVRMD 1047
Query: 132 LLTEAREEARRAFDGERLRLQQEILELKAARKQAEE----------ALSNCMQADKTKAA 181
L E A+R +G+ Q+ I++L+ ++Q +E AL+ ++ ++ +
Sbjct: 1048 L-----ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS 1102
Query: 182 DLRAAYQAHQDEVHRIKRE--CERDIRRLMDEIKGK-----DRVILALEKELGVQAGQTQ 234
L+ + Q + ++ E ER R +++++ + + LE+ G + Q +
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Query: 235 KLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD------ERDVR 288
++ + ++EA H + L D V +G Q ++ E++
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 289 RFQLKIAELNSVIRK-------LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNK 341
F+L++ ++ S + + LE L D+ NE ++ ET+ + L + ++
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 342 KNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQ 401
+N +L + + E I LTR L+ T Q++E L+ Q
Sbjct: 1283 ENGELSRQLDEKEALISQLTR---------------------GKLTYT---QQLEDLKRQ 1318
Query: 402 VLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSE----- 456
+ E+ + L+ L+S RH L+ +++ ET + + V S+ SE
Sbjct: 1319 LEEEVKAKNALA----HALQSARHDCDLLR--EQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 457 TSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTL-DA 515
T Y TD RT E A +EA+ + + +L++ LQ ++ + D
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 516 ERE-----ARTREQLQAD--LLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIR-TNQDLL 567
ER A ++Q D L + K E+ + L ++++ + + ++ ++ L
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
Query: 568 EKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQ 627
E + + E L+ E+ D +Q + ELE+ ++ A +++ + E ++L+
Sbjct: 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552
Query: 628 LFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEK-WLKQIEGTEA 686
H+EG K L + ++ E + + + + ++ L+ ++ +
Sbjct: 1553 ---HEEG----------KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Query: 687 ALTQKMLDLEKEKDLFSRQKGYLEE---ELDYRKQALDQAYLKIQDLEATLY-TALQQEP 742
+L + + + + +G L E +L + + +A +++ L++ L T +Q +
Sbjct: 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 743 GRRAGEALSE-------------GQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQ 789
RA + L E + E+L+A VE+ R R+ E + ER++LL
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS--RKLAEQELIETSERVQLLH 1717
Query: 790 QAQQRIRELEDKLEFQKRHLK-ELEE 814
+ + K++ L+ E+EE
Sbjct: 1718 SQNTSLINQKKKMDADLSQLQTEVEE 1743
Score = 87.8 bits (216), Expect = 4e-17
Identities = 187/883 (21%), Positives = 371/883 (42%), Gaps = 111/883 (12%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
++K+ ++ E + D +Q A E+ LT +++ +Q+ + E+ ++ +++ E+
Sbjct: 992 LTKEKKALQEAHQQALDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 61 EQRRHTAYISELKAKLHEEKTKEL----QALREGLIRQHEQEAARTAKIKEGEL--QRLQ 114
+R+ E KL +E +L Q L E L ++ + A A+I++ + +LQ
Sbjct: 1051 AKRK-----LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Query: 115 ATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQ 174
L L+ ++++ L EA AR + R L +E+ E+ ++A A S ++
Sbjct: 1106 KKLKELQ-ARIEELEEEL--EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Query: 175 ADKTKAA-------DLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKE-- 225
+K + A DL A H+ ++++ + L ++I RV LEKE
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 226 -----LGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELM----- 275
L ++++ K L++ +++ H S E + D+
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 276 --GVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERN----------------E 317
G + +DE++ QL +L + ++LED L +E +
Sbjct: 1283 ENGELSRQLDEKEALISQLTRGKL-TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD 1341
Query: 318 LLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASL 377
LL+ E E + K E + ++K N ++ Q + E T E E K+KL AQ
Sbjct: 1342 LLREQYEEETEAK--AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-AQRLQ 1398
Query: 378 KRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHV 437
+ ++ ++ E RLQ + I+DL ++ ER + K + K +
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQ-----NEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1453
Query: 438 VETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQA 497
E + ++ +S++ E+S R+ T E A EE+ RE +
Sbjct: 1454 AE----WKQKYEESQSELESSQKEARSLST-----ELFKLKNAYEESLEHLETFKRENKN 1504
Query: 498 LQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDLEKLLV-EKGQDSK-WVE 554
LQ + L EQ+G + E + R+QL+A+ + Q+ +E+ E L E+G+ + +E
Sbjct: 1505 LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Query: 555 EKQLLIRTNQDLLEKIYRLEM-EENQLK--NEMQDAKDQNELLEFRVLELEERERRSPAF 611
Q+ + L EK +E + N L+ + +Q + D L ++++
Sbjct: 1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK-MEGDLN 1623
Query: 612 NLQITTFPENHSSALQLFCHQEGVKDV-NVSELMKKLDILGDNGNLRNE---EQVAIIQA 667
++I N +A E K V ++ L+K I D+ N+ E +AI++
Sbjct: 1624 EMEIQLSHANRMAA-------EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1676
Query: 668 GTVLALCE-----KWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQ 722
L E ++Q E + Q++++ + L Q L + +K D
Sbjct: 1677 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK--KKMDADL 1734
Query: 723 AYLKIQDLEATLYTALQQEPGRRA-------GEALSEGQREDLQAAVEKVRRQILRQSRE 775
+ L+ + EA +E ++A E L + Q D A +E++++ + + ++
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKD 1792
Query: 776 FDSQI-------LRERMELLQQAQQRIRELEDKLEFQKRHLKE 811
++ L+ + LQ+ + R+RELE++LE +++ E
Sbjct: 1793 LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Score = 77.4 bits (189), Expect = 5e-14
Identities = 166/793 (20%), Positives = 327/793 (41%), Gaps = 138/793 (17%)
Query: 127 KVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAA 186
K+K L + RE+ + E RL++ + + +A RK+ EE + + +Q + DL+
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ----EKNDLQLQ 890
Query: 187 YQAHQDEVHRIKRECERDIR-RLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDE 245
QA QD + + C++ I+ ++ E K K+ + + L + +L +K L++
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKE-----MNERLEDEEEMNAELTAKKRKLED 945
Query: 246 QLVQVKEAERHHSSPKRELPPGIGDM-VELMGVQ-DQHMDERDVRRFQLKIAELNSVIRK 303
+ ++K I D+ + L V+ ++H E V+ ++A L+ +I K
Sbjct: 946 ECSELKR--------------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 991
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIK----- 358
L L + + L + E ++ L + ++ ++ +DL S+++ E+K++
Sbjct: 992 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ-EKKVRMDLER 1050
Query: 359 ---------NLTRENV---EMKEKLSAQASLKRHTSLNDLSL-TRDEQEI-EFLRLQVLE 404
LT+E++ E ++ + K+ LN L+ DEQ + L+ ++ E
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 405 QQHVIDDL--SLERERLLRSKRHRGKS-LKPPKKHV---VETFFGFDEESVDSETLSETS 458
Q I++L LE ER R+K + +S L + + +E G ++ E
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 459 YNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ---------- 508
+ R D AT + + A R++ +L + LQR L+++
Sbjct: 1171 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1230
Query: 509 --------VGGTLDAEREARTRE----QLQADLLRCQAKIEDL----EKLLVEKGQDSKW 552
+ + E+ RT E + ++ Q + DL KL E G+ S+
Sbjct: 1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ 1290
Query: 553 VEEKQLLIR-------TNQDLLEKIYRLEMEE----NQLKNEMQDAKDQNELLEFRVLE- 600
++EK+ LI T LE + R EE N L + +Q A+ +LL + E
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
Query: 601 ---LEERERRSPAFNLQITTFPENHSS----------------ALQLFCHQEGVKDVNVS 641
E +R N ++ + + + A +L +E V+ VN
Sbjct: 1351 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA- 1409
Query: 642 ELMKKLDILGDNGNLRNEEQ---VAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKE 698
K + L+NE + V + ++ A +K + + A QK + + E
Sbjct: 1410 ---KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 699 KDLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDL 758
+ ++ L EL K A +++ ++ + LQ+E + S G+
Sbjct: 1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQLGSSGKTIH- 1524
Query: 759 QAAVEKVRRQILRQSREFDS--------------QILRERMELLQ---QAQQRIRELEDK 801
+EKVR+Q+ + E S +ILR ++E Q + ++++ E +++
Sbjct: 1525 --ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE 1582
Query: 802 LEFQKR-HLKELE 813
+E KR HL+ ++
Sbjct: 1583 MEQAKRNHLRVVD 1595
Score = 58.2 bits (139), Expect = 3e-08
Identities = 76/397 (19%), Positives = 165/397 (41%), Gaps = 52/397 (13%)
Query: 8 KGEKPEMET--DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH 65
+ EK E+++ + + + E K+ Q+EF Q K+++ + +L E E EQ +R H
Sbjct: 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKDEEMEQAKRNH 1590
Query: 66 TAYISELKAKLHEEKTKELQALR-----EGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
+ L+ L E +ALR EG + + E + + ++ +++++ ++L
Sbjct: 1591 LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
+D + +E + LQ E+ EL+A +Q E + Q +
Sbjct: 1651 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1710
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
++ + + +++ K++ + D+ +L E++ + E++ +K +
Sbjct: 1711 ERVQLLHSQNTSLINQ-KKKMDADLSQLQTEVEEAVQECRNAEEK-------AKKAITDA 1762
Query: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQH-MDERDVRRFQLKIAELNS 299
+ E+L + ++ H K+ + I D+ QH +DE + Q+ +
Sbjct: 1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDL--------QHRLDEAE----QIALKGGKK 1810
Query: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
++KLE R R E E++ + K+N + ++ +++ E +IK
Sbjct: 1811 QLQKLEAR------------VRELENELEAE---------QKRNAESVKGMRKSERRIKE 1849
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIE 396
LT + E ++ L L L + R +E E
Sbjct: 1850 LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1886
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 95.9 bits (237), Expect = 1e-19
Identities = 158/858 (18%), Positives = 356/858 (41%), Gaps = 102/858 (11%)
Query: 17 DAVQMANEEL-RAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAK 75
D+ +A E+ R +L E Q+E + K R+ L+ K E + + +I E AK
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 76 LHEEKTKELQALREGLIRQHEQEAARTA------KIKEGELQRLQATL----NVLRDGAA 125
+ E ++K+ Q+L +++ + E + K K+ L R++ + L++
Sbjct: 1379 IQESQSKQEQSLN---MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 126 DKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALS---NCMQADKTKAAD 182
+ A + + + E +L++ I E+ A + EE L C++ + +
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
LR + E+ I+++ E + D+++ K + I E++ ++ Q
Sbjct: 1496 LRVNLSEKETEISTIQKQLE----AINDKLQNKIQEIYEKEEQFNIK---------QISE 1542
Query: 243 LDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIR 302
+ E++ ++K+ + H + L M+EL + +E + + + E+ V
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE--EMKRVQE 1600
Query: 303 KLEDRNTLLADERNEL---LKRSRETEVQLKPLVEKNKRMNK--KNEDLLQSIQRMEEKI 357
L+ L + E+ +K S+E E Q + N+ K + E L + + + +
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 358 KNLTRENVEMKEKLSAQASLKRHTSLNDL-SLTRDEQEIEFLRLQVLEQQHVIDDLSLER 416
+N+ EN+ + + L H +L ++ S+T++ ++ + V + L +ER
Sbjct: 1661 ENIETENIRLTQIL--------HENLEEMRSVTKERDDL----------RSVEETLKVER 1702
Query: 417 ERLLRSKR-------HRGKSLKPPKKHVVETFFGFDE-ESVDSETLSETS-YNTDRTDRT 467
++L + R + + LK H+ E D+ + SE +E S D
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 468 PATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAERE-----ARTR 522
A +DL +EE + L + + + + ++ E+ + +++ A+ +
Sbjct: 1763 DALKAQDL---KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819
Query: 523 EQLQA------DLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIR----TNQDLLEKIYR 572
E++Q L+ + + + +K + E Q K ++++ L + N +L +K++
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879
Query: 573 LEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQI-------TTFPENHSSA 625
E + E + + E L+ +L+E + + A +L+I + H
Sbjct: 1880 NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKET 1939
Query: 626 LQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEE----QVAIIQAGTVLALCEKWLKQI 681
+ + K + +S++ K LD D + +E ++ +++ + + K + ++
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 682 EGTEAALTQKMLDLEKEK-DLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQ 740
E + + L ++ + D F K E + R A ++ L+ + +L+
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR------RIKESLKM 2053
Query: 741 EPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELED 800
E + L E D Q K +++L ++ ++ LRE+ +++ +R E++D
Sbjct: 2054 ERDQFIA-TLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112
Query: 801 KLEFQKRHLKELEEKFLF 818
E R +LE++ F
Sbjct: 2113 HYECLNRLSLDLEKEIEF 2130
Score = 82.0 bits (201), Expect = 2e-15
Identities = 159/836 (19%), Positives = 347/836 (41%), Gaps = 109/836 (13%)
Query: 11 KPEMETDAVQMANEELR-AKLTSIQIEFQQEKSKVGKLRERLQEA----KLEREQEQRRH 65
K + ET + + N E +LT I E +E V K R+ L+ K+ER+Q
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ----- 1704
Query: 66 TAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAA 125
LK L E T++L+ E KI L+ Q T++ LR +
Sbjct: 1705 ------LKENLRETITRDLEKQEE-------------LKIVHMHLKEHQETIDKLRGIVS 1745
Query: 126 DKV-KTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLR 184
+K + + + + E + A + L++Q+E+ K+ +E + LR
Sbjct: 1746 EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK-----------LR 1794
Query: 185 AAYQAHQDEVHRIKRECERDIRRLMD---EIKGKDRVILALEKELGVQAGQTQKLLLQKE 241
D++ ++++ E +L + E+K + ++ L+K++ + ++ K+
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 242 ALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQD--QHMDER-DVRRFQLKIAELN 298
+ +Q + + + E + + ++L + +M +M +D + ++E + R QLK +
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Query: 299 SVIRKLEDRNTL-----LADERNELLKRSRET----EVQLKPLVEKNKRMNKKNEDLLQS 349
+ R LE + L L+ E E + + RE +Q+ + K ++K ++L +
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI---QKDLDKSKDELQKK 1971
Query: 350 IQRMEEKIKNLTR--ENVEMK-EKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQ 406
IQ +++K L R E+V M +K++ LK+ +LS+ Q + Q+ ++
Sbjct: 1972 IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM----QSVRMDNFQLTKKL 2027
Query: 407 HVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDR 466
H SLE R++ +R + +K K + F E + + ++ R
Sbjct: 2028 HE----SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD---RQNHQVKPEKR 2080
Query: 467 TPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQL- 525
+ ++ L ++ RE+ R +L + Y + Y L +LD E+E +++L
Sbjct: 2081 LLSDGQQHLTESL-REKCS-RIKELLKRYSEMDDHYECLNRL---SLDLEKEIEFQKELS 2135
Query: 526 ---QADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
+A+L + + +EKL + S E +++ + +L + +++ E+++ N
Sbjct: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSM---EFHRIMKKLKYVLSYVTKIKEEQHESIN 2192
Query: 583 EMQ-DAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVS 641
+ + D D+ E + +++++ ++ + ++ N + L + +E +KD + S
Sbjct: 2193 KFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHI---EEILKDFSES 2249
Query: 642 ELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDL 701
E +++ E Q + + E+WL T + + ++KE D
Sbjct: 2250 EFP----------SIKTEFQQVLSNRKEMTQFLEEWLN----TRFDIEKLKNGIQKENDR 2295
Query: 702 FSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAA 761
+ + + A+ + ++ AT+ +Q+ ++ + +E ++ Q
Sbjct: 2296 ICQVNNFFNNRII----AIMNESTEFEERSATISKEWEQD--LKSLKEKNEKLFKNYQTL 2349
Query: 762 VEKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFL 817
+ D++ Q ++IRELE+ L K E K +
Sbjct: 2350 KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Score = 76.3 bits (186), Expect = 1e-13
Identities = 167/869 (19%), Positives = 353/869 (40%), Gaps = 132/869 (15%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERL---------QEAKLEREQ 60
E+ +ET A M ++L L + + + K+ L L QE K +R++
Sbjct: 360 EEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKR 419
Query: 61 EQRRHTAYISELKAKLHEEK-------TKELQALREGLIRQHEQEAARTAKIKEGELQRL 113
I+++K + ++ T + L L+R+ ++ + + L
Sbjct: 420 RVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLD-- 477
Query: 114 QATLNVLRDGAADKVKTALLTEAREEARRA------FDGERLRLQQEILELKAARKQAEE 167
TL+ + A K+ E+ + RA D E+LR ++E +ELK K
Sbjct: 478 --TLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKN--- 532
Query: 168 ALSNCMQADKTKAADLRAAYQAHQDEVHRIK------RECERDIRRLMDEIKGKDRVILA 221
D+ +A + + +H I + E + L +E+ K V L
Sbjct: 533 ------DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK--VELL 584
Query: 222 LEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGI------GDMVELM 275
EKE Q +KL +E +D Q ++ + + +S E P + + V L
Sbjct: 585 REKE-----DQIKKL---QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636
Query: 276 GVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK 335
++ + + K+ EL + +++E+ L + K + E +L+ +
Sbjct: 637 AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
Query: 336 NKRMN-----KKNEDLLQSIQRMEEKIKNLTRE-NVEMKEKLSAQASLKRHTSLNDLSLT 389
++ K +DLL +++ +E KI +L +E N E++E + + + + L L
Sbjct: 697 ITKLTSLIDGKVPKDLLCNLE-LEGKITDLQKELNKEVEENEALREEVILLSELKSLP-- 753
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
E+E LR ++ ++ + ++ E+++L H+ ++ + + +T
Sbjct: 754 ---SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKT--------- 801
Query: 450 DSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQV 509
+ L+ T N TD +E + T + + ++ + E + + + L ++
Sbjct: 802 -KDDLATTQSNYKSTD------QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 510 G------GTLDAEREARTREQLQADLLRCQAKIEDLEKL---LVEKGQDSKWVE-EKQLL 559
G L E +T+E LQ Q ++ ++E+L L + + VE EK L+
Sbjct: 855 QKFDSSLGALKTELSYKTQE-LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI 913
Query: 560 IRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFP 619
Q LE++ L E++ LK + + + + L+ + + N+ I T
Sbjct: 914 TEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD---------TVNMNIDTQE 964
Query: 620 ENHSSALQLFCHQEGVKDVNVS---ELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEK 676
+ ++ L HQE + + E+ + L + + G ++E Q ++
Sbjct: 965 QLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG---------- 1014
Query: 677 WLKQIEGTEAALTQKMLDLEKEKDLFSRQKGY--LEEELDYRKQALDQAYLKIQDLEATL 734
+ + + EA TQ + K+ ++ +Q+ L +E + +Q L+ + + L+ L
Sbjct: 1015 -IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL 1073
Query: 735 -----YTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFD-----SQILRER 784
T QE R G+ L + Q Q ++++ SR D + L+E+
Sbjct: 1074 KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG-ELSRTCDRLAEVEEKLKEK 1132
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLKELE 813
+ LQ+ QQ++ +++++ ++ + E+E
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Score = 73.9 bits (180), Expect = 6e-13
Identities = 177/866 (20%), Positives = 363/866 (41%), Gaps = 113/866 (13%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAK-------LEREQEQRRHT 66
+ + ++ LRA ++ ++++Q +++ ++ +L+E LER+ ++ +
Sbjct: 491 LNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEM 550
Query: 67 AYISELK--------AKLHEEKTKELQALREGLIRQHEQEAARTAK-IKEGELQRLQATL 117
I E+ A+++ + + + + L+R+ E + + + I +L+ ++ L
Sbjct: 551 QLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDL 610
Query: 118 NVLRDGAADK---------VKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEA 168
+ + D +T L RE A E L L++++ EL KQ E
Sbjct: 611 SYSLESIEDPKQMKQTLFDAETVALDAKRESA--FLRSENLELKEKMKELATTYKQMEND 668
Query: 169 LS---NCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMD---EIKGKDRVILAL 222
+ + ++A K DL Q+ +E+ ++ + + + + E++GK I L
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK---ITDL 725
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+KEL K + + EAL E+++ + E + S +R L I D E + +
Sbjct: 726 QKELN-------KEVEENEALREEVILLSELKSLPSEVER-LRKEIQDKSEELHIITSEK 777
Query: 283 DE--RDVRRFQLKIAELNSVIRKLED------RNTLLADERNELLKRSR-ETEVQLKPLV 333
D+ +V + ++ L I K +D N D+ + K + E + K ++
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
Query: 334 EKNKRMNKKNEDLLQSIQRMEE-----------KIKNLTRENVEMKEKLSAQASLKRHTS 382
E+N+RMN++ +L + Q+ + K + L + E++E+L+ LK
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 383 LNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFF 442
D +L E+E + ++ + + L+ E++ L + +SL+ + +
Sbjct: 898 NRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL----KQLQESLQIERDQLKSDIH 953
Query: 443 GFDEESVDS-ETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRA 501
++D+ E L + + T T + + + +R L E +
Sbjct: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR--------NLHMEENTGETK 1005
Query: 502 YALLQEQVGGTLDAEREARTREQLQAD-----LLRCQAKIEDL--EKLLVEKGQDSKWVE 554
Q+ VG + EA+ + L AD ++ Q KI L EK +++ +S E
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE 1065
Query: 555 EKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELL---EFRVLELEERERRSPAF 611
++QL DL E I + +L+ + K Q E++ + ++ E R+
Sbjct: 1066 KEQL----KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121
Query: 612 NLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVL 671
++ + S LQ Q +SE+ KK++ + NL+NE L
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN---EIENLKNE-----------L 1167
Query: 672 ALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLE 731
E L+ +E L QK+ + +E ++++ L+E + D I+++E
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 732 ATLYTALQ-QEPGRRAGEALSEGQR--EDLQAAVEKVRRQILR-QSREFDSQILRERMEL 787
A T LQ +E + A L E Q ++L+ +V + QI+ Q E L+E + +
Sbjct: 1228 A---TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV 1284
Query: 788 LQQAQQRIRELEDKLEFQKRHLKELE 813
L + Q+ + +++ E Q+ + ELE
Sbjct: 1285 LHEEQELLPNVKEVSETQET-MNELE 1309
Score = 66.6 bits (161), Expect = 9e-11
Identities = 167/876 (19%), Positives = 355/876 (40%), Gaps = 133/876 (15%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEA--KLEREQEQRRHTAYIS 70
E DA++ + +++ +L + ++++ + KLR + E KL Q+ +
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD------LE 1812
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ-----ATLNVLRDGAA 125
AKL +EK +EL+A LI + K+ E E + Q TL+ L
Sbjct: 1813 NSNAKL-QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE---I 1868
Query: 126 DKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRA 185
+ + A E ++ ER L++ LK R Q +E+L +TKA DL
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL------QETKARDLE- 1921
Query: 186 AYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDE 245
Q + +E + + +L ++I K I ++K+L + QK + + + +
Sbjct: 1922 -IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 246 QLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLK------------ 293
QL++VKE E+ + + Q+ M + FQL
Sbjct: 1981 QLLRVKEDVNMSHKKINEME----QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
Query: 294 IAELNSVIRKLEDRNTLLADE----RNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQS 349
+A+ +R++++ + D+ E++ R R+ Q+KP + + ++ + L +S
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNH-QVKP---EKRLLSDGQQHLTES 2092
Query: 350 IQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF-----------L 398
++ +IK L + EM + + LN LSL E+EIEF L
Sbjct: 2093 LREKCSRIKELLKRYSEMDD---------HYECLNRLSLDL-EKEIEFQKELSMRVKANL 2142
Query: 399 RLQVLEQQHV------IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDS- 451
L L+ +H+ S+E R+++ ++ + K+ E+ F+ + +D
Sbjct: 2143 SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEV 2202
Query: 452 ETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGG 511
E E + P +L D + DL ++ +++ + + ++ +
Sbjct: 2203 EKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFS--ESEFPSIKTEFQQ 2260
Query: 512 TLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG----QDSKWVEEKQLLIRTNQDLL 567
L +E Q + L + IE L+ + ++ Q + + + + I
Sbjct: 2261 VLSNRKE---MTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317
Query: 568 EKIYRLEMEENQLKNEMQDAKDQNELL--EFRVLELE----------ERERRSPAFNLQI 615
E+ R + + +++ K++NE L ++ L+ ++ ++P +
Sbjct: 2318 EE--RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375
Query: 616 TTFPENHSSALQLFCHQEGV----KDVNVSELMKKLDILGD------------NGNL-RN 658
T L+ H+ K+ + ++ K+L++ D N L +
Sbjct: 2376 TQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKT 2435
Query: 659 EEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDL--FSRQKGYLEEELDYR 716
+E + ++Q L + + ++IE + L + +DLEK K+ F ++ + ++Y+
Sbjct: 2436 KETIQVLQDKVALG-AKPYKEEIEDLKMKLVK--IDLEKMKNAKEFEKEISATKATVEYQ 2492
Query: 717 KQA---LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQS 773
K+ L + + Q + T + +P + + + L+ G + V+ + IL+
Sbjct: 2493 KEVIRLLRENLRRSQQAQDTSVISEHTDP-QPSNKPLTCGGGSGI---VQNTKALILKSE 2548
Query: 774 REFDSQILRERMELLQQAQQRIRELEDKLEFQKRHL 809
++ +E +L QQ +Q I++ +++L +HL
Sbjct: 2549 H---IRLEKEISKLKQQNEQLIKQ-KNELLSNNQHL 2580
Score = 53.9 bits (128), Expect = 6e-07
Identities = 144/732 (19%), Positives = 280/732 (38%), Gaps = 153/732 (20%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQ-------QEKSKVGKLRERLQEAKLEREQEQ 62
E ++E D ++ + +E +A+ IQ E + + K V KLRE++ E ++ Q
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ 1958
Query: 63 RRHTAYISELKAKLHEEKTKELQALR---------------EGLIRQHEQ---------- 97
+ EL+ K+ E + KELQ LR E L +Q E
Sbjct: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
Query: 98 -------------EAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTE-----AREE 139
E R + EL+R++ +L + RD ++ + + + E
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 140 ARRAFDGERL---RLQQEILELKAARKQAEEA-----LSNCMQADKTKA----------- 180
R DG++ L+++ +K K+ E N + D K
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 181 -ADLRAAY--QAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
A+L Y H +++ + C + R+M ++K + +++E + +
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 238 LQK-EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE------------ 284
+ + E E L++++ ++ P REL ++L D H++E
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRD-----LKLNQNMDLHIEEILKDFSESEFPS 2253
Query: 285 ------------RDVRRF-------QLKIAELNSVIRKLEDR---------NTLLA--DE 314
+++ +F + I +L + I+K DR N ++A +E
Sbjct: 2254 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
Query: 315 RNELLKRS----RETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTREN-----V 365
E +RS +E E LK L EKN+++ K + L S+ + + T++N
Sbjct: 2314 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ-VNPTTQDNKNPHVT 2372
Query: 366 EMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRH 425
+L+ + + SL++ + +E + +++Q ++ V +D+ + L++K H
Sbjct: 2373 SRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ--KELEVTNDIIAK----LQAKVH 2426
Query: 426 RGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA-TARE-E 483
K ++ D L Y + D + DL+ A+E E
Sbjct: 2427 ESNKCLEKTKETIQVL-------QDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE 2479
Query: 484 ADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA----RTREQLQADLLRCQ--AKIE 537
++ + T EYQ + LL+E + + A+ + T Q L C + I
Sbjct: 2480 KEISATKATVEYQ--KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIV 2537
Query: 538 DLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFR 597
K L+ K + + +E L + N+ L+++ L L NE++ K++ E
Sbjct: 2538 QNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAH 2597
Query: 598 VLELEERERRSP 609
E +SP
Sbjct: 2598 KQVTCENSPKSP 2609
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 95.5 bits (236), Expect = 2e-19
Identities = 171/835 (20%), Positives = 349/835 (41%), Gaps = 105/835 (12%)
Query: 56 LEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEG-ELQRLQ 114
L R+Q++ + +KA ++ G++R+ E+ + + K L+++Q
Sbjct: 298 LLRDQQEAAPPGSVDHMKATIY------------GILREGSSESETSVRRKVSLVLEKMQ 345
Query: 115 ATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQ 174
+ V LT EE +R D E + Q+ +Q EE C +
Sbjct: 346 PLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSR 405
Query: 175 ADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIK----GKDRVILALEKELG-VQ 229
L+ + + E + +E + +++RL+D+ + G + ++ L+ +L VQ
Sbjct: 406 --------LQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQ 456
Query: 230 AGQTQK------LLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ K LL +E L+E L + E +REL G + E + +DQ +
Sbjct: 457 GPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV- 515
Query: 284 ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKN 343
E +++Q +L ++ + +L ER ++ R + +L+ E+
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 344 EDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVL 403
+ + ++ ++++ L E EM+E+L + + + + D +++E L+ ++L
Sbjct: 576 QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELL 635
Query: 404 EQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHV-VETFFGFDEESVD---SETLSETSY 459
Q + +L ER+ + RHR + L+ + VE G + E + +TL +
Sbjct: 636 RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
Query: 460 NTDRTDRTPATPEED---LDDATAREEADLRFCQLTREYQALQRAYALLQEQV---GGTL 513
+ + + E + L A E LR Q E +R L++Q+ G +
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ--EENDEFRRRILGLEQQLKETRGLV 753
Query: 514 DAER--EARTREQLQADLLRCQAKIEDLEKLL-VEKGQDSKWVEEKQLLIRTNQDLLEKI 570
D EAR R++LQ R +A+ + LE+ L + ++ K+ L ++ +
Sbjct: 754 DGGEAVEARLRDKLQ----RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
Query: 571 YRLEMEENQLKNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQITTFPENHSSAL 626
RL E+ L +++ Q E+L ELEE+ +R N ++ E+ AL
Sbjct: 810 ARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQAL 869
Query: 627 -QLFCHQEGVKDVNVSELMKKLDILGD---------NGNLRNEEQVAIIQAGTVLALCEK 676
QL E K+ E+ D G R ++++ ++ + E+
Sbjct: 870 QQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAER 929
Query: 677 WLKQIEGTEAALTQKMLDLEKEKDLFSRQK--------------GYLEEELDYRKQALDQ 722
+++ + L Q++ LE+E + R + LE ELD K ++
Sbjct: 930 DTARLD--KELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL 987
Query: 723 AYLKI---QDLEATLYTALQQEPGRR----AGEALSEGQREDLQ---AAVEKVRRQILRQ 772
++ +D L T L QE R + E Q +DL+ A+ E ++
Sbjct: 988 LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASL 1047
Query: 773 SR-EFDSQILRERME-------LLQ----QAQQRIRELEDKLEFQKRHLKELEEK 815
S+ E +Q+L+ER++ +LQ + +++++EL ++E +++H+ + +++
Sbjct: 1048 SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQ 1102
Score = 87.8 bits (216), Expect = 4e-17
Identities = 140/621 (22%), Positives = 263/621 (42%), Gaps = 86/621 (13%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
+Q EE + Q FQ+ K + ++ L + ++E+E+ + I L+ +L +
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616
Query: 79 EK-----TKELQALREGLIRQHEQEAARTAKIKEGELQRL-QATLNVLRDGAADKVKTAL 132
+ T++++ L++ L+R E+ +KE + +R Q RD +K L
Sbjct: 617 ARASAGDTRQVEVLKKELLRTQEE-------LKELQAERQSQEVAGRHRDRELEKQLAVL 669
Query: 133 LTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQD 192
EA + R + + L+LQ+ + +L+ ++A +A +A+ T RAA +
Sbjct: 670 RVEA--DRGRELEEQNLQLQKTLQQLRQDCEEASKA-KMVAEAEATVLGQRRAAVETTLR 726
Query: 193 EVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKE 252
E E R I L ++K ++ E + Q+L +K+ L+E L +E
Sbjct: 727 ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE 786
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLA 312
E ++ KR L + + +R + R + LN R LE+
Sbjct: 787 EEGSLAAAKRALEARLEEA------------QRGLARLGQEQQTLN---RALEEEG---- 827
Query: 313 DERNELLKRSRETEVQLKPLVEK-----NKRMNKKNEDLLQSIQRMEEKIKNLTRENVEM 367
++ E+L+R + + K L+++ NK + K ED Q++Q+++ ++++ +
Sbjct: 828 -KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEK--AR 884
Query: 368 KEKLSAQASLKRHTSLNDLS---LTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL---- 420
+E AQ K S + + L+R + EI+ LR + Q D L++E L
Sbjct: 885 REVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQ 944
Query: 421 ----------RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPAT 470
RS+ R + LK ++ V DEE E L++ N R D+
Sbjct: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR-VNRGR-DQVDQL 1002
Query: 471 PEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLL 530
E + + +AR++ + L R+ + L+ A + ++ A L
Sbjct: 1003 RTELMQERSARQDLECDKISLERQNKDLKTRLA--------------SSEGFQKPSASL- 1047
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
+++E +LL E+ Q + EK +L TN+ L K+ L ++ + + D KDQ
Sbjct: 1048 ---SQLESQNQLLQERLQAEE--REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQ 1102
Query: 591 NEL----LEFRVLELEERERR 607
L L+ +V E EE R
Sbjct: 1103 LSLRVKALKRQVDEAEEEIER 1123
Score = 37.0 bits (84), Expect = 0.075
Identities = 56/260 (21%), Positives = 107/260 (41%), Gaps = 43/260 (16%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+K S+ EK +Q + LR L + Q E + L +RLQ + E E +
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
Query: 62 QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLR 121
+R +++ ++L+ L E + R E EL + T+ +L
Sbjct: 954 KRS------------QDDRARQLKGLEEKVSR------------LETELDEEKNTVELLT 989
Query: 122 D------GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQA 175
D D+++T L+ E AR+ + +++ L+++ +LK A S Q
Sbjct: 990 DRVNRGRDQVDQLRTELMQE--RSARQDLECDKISLERQNKDLK-----TRLASSEGFQK 1042
Query: 176 DKTKAADLRAAYQAHQDEVHRIKRE---CERDIRRLMDEIKGKDRVILALEKELGVQAGQ 232
+ L + Q Q+ + +RE + R+L ++K + + +E E Q
Sbjct: 1043 PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK---ELSIQIEDERQHVNDQ 1099
Query: 233 TQKLLLQKEALDEQLVQVKE 252
+L L+ +AL Q+ + +E
Sbjct: 1100 KDQLSLRVKALKRQVDEAEE 1119
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 94.7 bits (234), Expect = 3e-19
Identities = 172/839 (20%), Positives = 351/839 (41%), Gaps = 70/839 (8%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH 65
+ K K E+ +Q+ANE + TS+ + Q+EK+++ + E LQ QEQ
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 66 TAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAA 125
A ++EL+ +L E+ K + +E + ++ +Q + +KE L+ + +L + AA
Sbjct: 670 QAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQLQALKE-SLKVTKGSLEEEKRRAA 726
Query: 126 DKV--KTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
D + + ++E + E R + + R ++E+ E +A RK E L +A + + L
Sbjct: 727 DALEEQQRCISELKAETRSLVE-QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
R H + ECE+ ++ + ++R + ++E A ++L+ KE
Sbjct: 786 RRELAEAMAAQHTAESECEQLVKEV---AAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842
Query: 244 DEQLVQVKEAERH----HSSPKRELPPGIGDMVEL---MGVQDQHMDERDVRRFQL---- 292
++ +++EA+ S + ++ ++ EL + Q + E++VR +L
Sbjct: 843 EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902
Query: 293 ------------KIAELNSVIRKLEDRNTLLADERNELLKR-SRETEVQLKPLVEKNKRM 339
++A L +++RK ++ + EL+K +R + Q + L E+ R
Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQQETAS---RELVKEPARAGDRQPEWLEEQQGRQ 959
Query: 340 NKKNEDLLQSIQRMEEKIKN-LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFL 398
+ LQ+++R E++ N L R + E +Q + + + R QE
Sbjct: 960 FCSTQAALQAMEREAEQMGNELERLRAALME---SQGQQQEERGQQEREVARLTQERGRA 1016
Query: 399 RLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDE--------ESVD 450
+ + ++ +L + + L +R +L+ H + G D+ E+
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 451 SETLSETSYNTDRTDRTPATPE-EDLDDATAREEADLRFCQLTREYQALQRAYALLQEQV 509
+ L E + A E E + A+ EA R + +AL+ + L++Q
Sbjct: 1077 IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
Query: 510 GGTLD-AEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL- 567
+ A+ R+ E +A + +E L+ L EK Q+ + L ++L
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG--HSQSALASAQRELAA 1194
Query: 568 --EKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSA 625
K+ E++ K ++ + + E + LEE N Q+ E S
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEE---EVSILNRQVLE-KEGESKE 1250
Query: 626 LQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTE 685
L+ E K + E ++ L + + R E+ + ++ V +L E+ KQ +E
Sbjct: 1251 LKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE-EVQSLREEAEKQRVASE 1309
Query: 686 AALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLK-------IQDLEATLYTAL 738
+ E+ ++L K + +E+ ++QAL L+ + +L +
Sbjct: 1310 NLRQELTSQAERAEELGQELKAW-QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ 1368
Query: 739 QQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQI-LRERMELLQQAQQRIR 796
Q + + A E + E + A +R ++LR RE I LR+++ ++ Q++R
Sbjct: 1369 QLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427
Score = 92.0 bits (227), Expect = 2e-18
Identities = 179/862 (20%), Positives = 337/862 (39%), Gaps = 133/862 (15%)
Query: 26 LRAKLTSIQIEFQQEKSKVGKLRERLQEAKLE-----REQEQR----RHTAYISELKAKL 76
L ++LT++ QQ+ ++ L+++ +E + + ++QEQ RH K
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 77 HEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEA 136
E++ KE+ +E + H Q+ A A+ +E L+ A L L A +K K A L
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE--ALEKEKAAKLE-- 618
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD---KTKAADLRAAYQAHQDE 193
LQQ++ AR A+ +++ + K +L+A + + E
Sbjct: 619 -------------ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 194 VHRIKRE-CERDIRRLMDEIKGKDRVILALEKELGVQAGQTQK--LLLQKEALDEQLVQV 250
H + + E +++ ++ K ++ +A EK+ + Q K L + K +L+E+ +
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
Query: 251 KEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTL 310
+A EL +VE + + ++E R L+ A L + + +
Sbjct: 726 ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLE-ARLQQLGEAHQAETEV 784
Query: 311 LADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQ-----------SIQRMEEKIKN 359
L E E + E + + LV++ ++ ED Q + ++E+ +
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLR------LQVLEQ-----QHV 408
+E E KEK+ A ++ H ++L ++R + E+ L LQ +++ Q +
Sbjct: 845 ARQELQEAKEKV---AGIESH---SELQISRQQNELAELHANLARALQQVQEKEVRAQKL 898
Query: 409 IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTP 468
DDLS +E++ + + + +K G +E+ E + E + DR
Sbjct: 899 ADDLSTLQEKMAATSKEVARLETLVRK------AGEQQETASRELVKEPARAGDR----- 947
Query: 469 ATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQAD 528
PE E+ +FC QA++R +AE+ E+L+A
Sbjct: 948 -QPE------WLEEQQGRQFCSTQAALQAMER-------------EAEQMGNELERLRAA 987
Query: 529 LLRCQAKIEDLEKLLVEKGQDSKWVEE-KQLLIRTNQDL-LEKIYRLEME---ENQLKNE 583
L+ Q + ++ E+GQ + V Q R DL LEK R E+E +N L +
Sbjct: 988 LMESQGQQQE------ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 584 MQDAKDQNELLEFRVLELEERERRSPAFN----LQITTFPENHSSALQLFCHQEGVKDVN 639
+ E L + E E +++ QI E + QL + +
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
Query: 640 VSELMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEK 699
S + + G + + + + C+K +Q + E +L + +
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD 1161
Query: 700 DLFSRQKGYLEE---ELDYRKQALDQAYLKIQDLEATL--YTALQQEPGRRAGEALSEGQ 754
+G LEE EL + + AL A ++ + ++ + E + E +
Sbjct: 1162 SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 755 RED-----LQAAVEKVRRQILRQSREF------------DSQILRERMELLQ----QAQQ 793
R++ L+ V + RQ+L + E SQ L ER+ LLQ
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 794 RIRELEDKLEFQKRHLKELEEK 815
R E L + + L+E EK
Sbjct: 1282 RAAERSSALREEVQSLREEAEK 1303
Score = 88.2 bits (217), Expect = 3e-17
Identities = 188/930 (20%), Positives = 359/930 (38%), Gaps = 150/930 (16%)
Query: 8 KGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA 67
K E+ + + + E +A++ ++++ + E+ K + +ER+ + K + +++ +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE-KERVAQEKDQLQEQLQALKE 709
Query: 68 YISELKAKLHEEKTKELQALRE-------------GLIRQHEQEAARTAKIKEGELQRLQ 114
+ K L EEK + AL E L+ QH++E + + G + L+
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR-KGLE 768
Query: 115 ATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARK-----QAEEAL 169
A L L G A + +T +L EA A +Q + E+ A R+ Q EEA
Sbjct: 769 ARLQQL--GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQ 826
Query: 170 SNCMQAD-----KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEK 224
M + K + R Q +++V I+ E I R +E+ + +
Sbjct: 827 YGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQ 886
Query: 225 ELGVQAGQTQKLLLQKEALDEQLVQ-----------VKEAERHHSSPKREL---PPGIGD 270
++ + + QKL L E++ V++A + REL P GD
Sbjct: 887 QVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946
Query: 271 MVELMGVQDQHMDERDVRRF----------------------QLKIAELNSVIRKLEDRN 308
Q + ++E+ R+F +L+ A + S ++ E+R
Sbjct: 947 R------QPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG 1000
Query: 309 ------TLLADERNEL-----LKRSRETEVQLK---------------------PLVEKN 336
L ER L+++ E++++ L EK
Sbjct: 1001 QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 337 KRMN-------------KKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSL 383
+ K+ E+L Q++++++E++ +E+ AQ+ T
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS---GAQSEAAGRTEP 1117
Query: 384 NDLSLTRDEQEIEFLRLQVLEQQHVIDDL--SLERERLLRSKRHRGKSLKPPKKHVVETF 441
L E+ L Q +QQ D L SLE ER R++R +
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
Query: 442 FGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRA 501
G + ++ S ++ T D + A E A R+EA+ + ++ +L+
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS----SLEEE 1233
Query: 502 YALLQEQVGGTLDAEREARTREQL-QADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLI 560
++L QV L+ E E++ ++L A+ + Q E L L E +S E+ +
Sbjct: 1234 VSILNRQV---LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
Query: 561 RTN-QDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEER----ERRSPAFNLQI 615
R Q L E+ + + L+ E+ ++ E L + +E+ E+ L+
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Query: 616 TTFPENHSSAL-------QLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAG 668
T+ S L QL Q + + EL + G LR E A + G
Sbjct: 1351 TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAG---GLRAELLRAQRELG 1407
Query: 669 TVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQ 728
++ L +K +Q E T L + ++ + + G L EE + ++A L Q
Sbjct: 1408 ELIPLRQKVAEQ-ERTAQQLRAEKASYAEQLSMLKKAHGLLAEE---NRGLGERANLGRQ 1463
Query: 729 DLEATLYTALQQEPGRRAG-EALSEGQREDLQAAVEKVRRQILRQSREFDS---QILRER 784
LE L A ++ A A +E + ++Q + R++ + +++ ++L ER
Sbjct: 1464 FLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEER 1523
Query: 785 MELLQQAQQRIRELEDKLEFQKRHLKELEE 814
++ Q+ ++E FQ+ K++EE
Sbjct: 1524 QRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Score = 80.5 bits (197), Expect = 6e-15
Identities = 191/912 (20%), Positives = 365/912 (40%), Gaps = 150/912 (16%)
Query: 9 GEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAY 68
GE + ET+ ++ E A + + E +Q +V RER +++ +QE+ ++ A
Sbjct: 775 GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS----QQEEAQYGAM 830
Query: 69 ISELKAKLHEEKTKELQALREG--------------LIRQHEQEAARTAKI--------- 105
E L EE K Q L+E + RQ + A A +
Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 106 KEGELQRLQATLNVLRD--GAADKVKTALLT------EAREEARRAFDGERLRL---QQE 154
KE Q+L L+ L++ A K L T E +E A R E R Q E
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 155 ILELKAARKQAE-EALSNCMQADKTKAAD----LRAAYQAHQDEVHRIKRECERDIRRLM 209
LE + R+ +A M+ + + + LRAA Q + + + ER++ RL
Sbjct: 951 WLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLT 1010
Query: 210 DEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIG 269
E +G+ + LALEK A + + + + AL+EQ V+ + + E
Sbjct: 1011 QE-RGRAQADLALEK-----AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 270 DMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQL 329
++ +L G++ + E + R +K +L + K E + + ++E R+ T +L
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVK--QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 330 KPL---VEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLK-RHTSLND 385
+ L V K ++ +K ++ S++R E + E E L Q K + +
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Query: 386 LSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFD 445
+L ++E+ R +V + D+ +++ RG+ K ++ + +
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEW--------KAQVARGRQEAERKNSLISSLE--E 1232
Query: 446 EESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQL---TREYQALQRAY 502
E S+ + + E + R E + + E LR Q + +A +R+
Sbjct: 1233 EVSILNRQVLEKEGESKELKRLVMAESEK----SQKLEERLRLLQAETASNSARAAERSS 1288
Query: 503 ALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLL--- 559
AL +E +AE++ E L+ +L + E+L + L K K+ +++Q L
Sbjct: 1289 ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL--KAWQEKFFQKEQALSTL 1346
Query: 560 -----------------------IRTNQDLLEKIYRLEMEENQ-----LKNEMQDA-KDQ 590
++ Q EK +R E+E+++ L+ E+ A ++
Sbjct: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL 1406
Query: 591 NELLEFRVLELEERERRSPAFNLQITTFPENHS---SALQLFCHQEGVKDVNVSELMKKL 647
EL+ R ++ E+ER + + ++ E S A L + + + L
Sbjct: 1407 GELIPLRQ-KVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1465
Query: 648 DILGDNGNLRNEEQVAIIQAGTVLALCEKWLK-------------QIEGTEAALTQKMLD 694
++ D + +++A ++A L E + + EG + + ++
Sbjct: 1466 EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR 1525
Query: 695 LEKEK----------DLFSRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGR 744
++E+ ++F R++ EEL + DQA K+Q + A+Q + G
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS-KVQQQKLK---AVQAQGGE 1581
Query: 745 RAGEALS-EGQREDLQA-------AVEKVRRQILRQSREFDS-----QILRERMELLQQA 791
EA + Q +LQA A E + Q+ + +D+ Q L+E++ L+Q
Sbjct: 1582 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641
Query: 792 QQRIRELEDKLE 803
Q+ +EL + E
Sbjct: 1642 QKENKELRAEAE 1653
Score = 80.1 bits (196), Expect = 8e-15
Identities = 169/792 (21%), Positives = 310/792 (39%), Gaps = 125/792 (15%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLERE- 59
M +G+ + E+ + E + ++ E RA Q + EK+ +L RLQ A E+
Sbjct: 989 MESQGQQQEERGQQEREVARLTQERGRA-----QADLALEKAARAELEMRLQNALNEQRV 1043
Query: 60 -----QEQRRHTAYISELKAK-------LHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
QE H E K + L + KEL+ LR+ + + EQ A + +
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 108 G----------------ELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGER--- 148
G +L+ L+A ++ L + + A E EA RA ER
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163
Query: 149 LRLQQEILELKAARK-QAEEALSNCMQ---ADKTKAADLRAAYQAHQDEVHRIKRECERD 204
L Q LE KA ++ AL++ + A +TK D A + +V R ++E ER
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER- 1222
Query: 205 IRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKREL 264
K+ +I +LE+E+ + Q +L+KE ++L ++ AE S E
Sbjct: 1223 ----------KNSLISSLEEEVSILNRQ----VLEKEGESKELKRLVMAESEKSQKLEE- 1267
Query: 265 PPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRE 324
+ L+ + R R E+ S+ + E + + R EL ++
Sbjct: 1268 ------RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 325 TEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMK---EKLSAQ--ASLKR 379
E + L ++ +K E L ++Q + L E + K ++L A+ A+ KR
Sbjct: 1322 AEELGQELKAWQEKFFQK-EQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
Query: 380 HTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVE 439
H L + +Q LR ++L Q + +L R+++ +R + L+ K E
Sbjct: 1381 HRE----ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER-TAQQLRAEKASYAE 1435
Query: 440 TFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA---------TAREEADLRFCQ 490
+ E +R + E +LD A R +A+ R +
Sbjct: 1436 QLSML--KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE 1493
Query: 491 LTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAK------------IED 538
+ RE Q+ R ++ + G E R R Q + L Q + +E+
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 539 LEKLLVEKGQDSKWVEEKQLLIRT-NQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFR 597
L K L + Q SK ++K ++ + ++ RL+ + N+L+
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ---------------- 1597
Query: 598 VLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKK--LDILGDNGN 655
+L ++E+ + + LQ+ ++ + Q +QE + + E ++K ++ +
Sbjct: 1598 -AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ--NQELQEQLRSLEQLQKENKELRAEAER 1654
Query: 656 LRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALT---QKMLDLEK---EKDLFSRQKGYL 709
L +E Q A ++ C Q+ EA + Q++ DL K D ++
Sbjct: 1655 LGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA 1714
Query: 710 EEELDYRKQALD 721
+ +LD +LD
Sbjct: 1715 KPQLDLSIDSLD 1726
Score = 70.5 bits (171), Expect = 6e-12
Identities = 150/715 (20%), Positives = 276/715 (38%), Gaps = 118/715 (16%)
Query: 151 LQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMD 210
LQ +++ +KQ + SN R + E ++ E + I +
Sbjct: 209 LQTPQFQMRRLKKQLADERSN------------RDELELELAENRKLLTEKDAQIAMMQQ 256
Query: 211 EIKGKDRVILALEKELG--VQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGI 268
I DR+ L EK+ ++ + ++L + E+L +L + + + + K ++ I
Sbjct: 257 RI---DRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 269 GDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERN----ELLKRSRE 324
+ E G K+ E S +++L+D L +E + E L++ +
Sbjct: 314 NQLSEENG------------DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
Query: 325 TEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL----TRENVEMKEKLSAQASLKRH 380
E +L ++ K + +KNE L + ++EE + L +E E+ + +LK+
Sbjct: 362 LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Query: 381 TSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVET 440
+ + T+ + +E L + +Q+ +LL + H
Sbjct: 422 AATLAANNTQLQARVEMLETERGQQE----------AKLLAERGH--------------- 456
Query: 441 FFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADL--RFCQLTREYQAL 498
F+EE + LS + + + +E+L+ A+ A L + LT E L
Sbjct: 457 ---FEEE---KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 499 QRAYALLQEQVGGTLDAERE-----ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
+++ G +E A+T +Q + + ++E L L +K Q K V
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 554 EEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEERERRSPAFNL 613
EKQ T QD +++ E E A Q E LE +E+ +
Sbjct: 571 AEKQ--EATRQDHAQQLATAAEEREASLRERDAALKQLEALE------KEKAAKLEILQQ 622
Query: 614 QITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVAIIQAGTVLAL 673
Q+ E SA Q Q + +S +++L + E A + A L L
Sbjct: 623 QLQVANEARDSA-QTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV-AELELQL 680
Query: 674 CEKWLKQIEGTEAALTQKML--DLEKEKDLFSRQKGYLEEELDYRKQALDQAYLKIQDLE 731
+ K E A + L L+ K+ KG LEEE AL++ I +L+
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
Query: 732 ATLYTALQQ-----------EPGRRAGEALSEGQREDLQAAVEKVRRQI-----LRQSRE 775
A + ++Q GR+ EA + E QA E +RR++ + + E
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 776 FDSQIL-------RERMELLQQA--------QQRIRELEDKLEFQKRHLKELEEK 815
+ + L RER E QQ Q+++ L+++ E ++ L+E +EK
Sbjct: 801 SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 855
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,753,760
Number of Sequences: 37866
Number of extensions: 1270384
Number of successful extensions: 16981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 319
Number of HSP's successfully gapped in prelim test: 1075
Number of HSP's that attempted gapping in prelim test: 6838
Number of HSP's gapped (non-prelim): 6186
length of query: 831
length of database: 18,247,518
effective HSP length: 111
effective length of query: 720
effective length of database: 14,044,392
effective search space: 10111962240
effective search space used: 10111962240
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.