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Search of human proteins with 150010552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
(1219 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 2383 0.0
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 107 5e-23
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 106 1e-22
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 103 1e-21
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 102 2e-21
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 97 7e-20
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 90 1e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 89 3e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 89 3e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 2e-16
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 86 2e-16
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 86 2e-16
gi|148746195 trichohyalin [Homo sapiens] 86 2e-16
gi|32698688 citron [Homo sapiens] 86 2e-16
gi|38044112 restin isoform b [Homo sapiens] 85 4e-16
gi|4506751 restin isoform a [Homo sapiens] 85 4e-16
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 85 4e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 85 4e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 85 4e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 85 4e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 85 4e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 85 4e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 85 4e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 85 4e-16
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 84 6e-16
gi|31982906 cingulin-like 1 [Homo sapiens] 84 6e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 84 8e-16
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 83 1e-15
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 83 1e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 83 2e-15
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 2383 bits (6175), Expect = 0.0
Identities = 1219/1219 (100%), Positives = 1219/1219 (100%)
Query: 1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQA 60
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQA
Sbjct: 1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQA 60
Query: 61 TPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQP 120
TPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQP
Sbjct: 61 TPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQP 120
Query: 121 VTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA 180
VTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
Sbjct: 121 VTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA 180
Query: 181 VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKG 240
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKG
Sbjct: 181 VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKG 240
Query: 241 WEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGH 300
WEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGH
Sbjct: 241 WEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGH 300
Query: 301 SVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV 360
SVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
Sbjct: 301 SVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV 360
Query: 361 KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALP 420
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALP
Sbjct: 361 KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALP 420
Query: 421 QMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQ 480
QMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQ
Sbjct: 421 QMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQ 480
Query: 481 LQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL 540
LQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
Sbjct: 481 LQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL 540
Query: 541 QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIE 600
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIE
Sbjct: 541 QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIE 600
Query: 601 RNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMT 660
RNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMT
Sbjct: 601 RNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMT 660
Query: 661 AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 720
AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
Sbjct: 661 AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 720
Query: 721 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK 780
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK
Sbjct: 721 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK 780
Query: 781 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ 840
KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ
Sbjct: 781 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ 840
Query: 841 LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR 900
LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
Sbjct: 841 LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR 900
Query: 901 EFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQS 960
EFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQS
Sbjct: 901 EFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQS 960
Query: 961 ASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEI 1020
ASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEI
Sbjct: 961 ASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEI 1020
Query: 1021 KDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCV 1080
KDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCV
Sbjct: 1021 KDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCV 1080
Query: 1081 REVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSS 1140
REVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSS
Sbjct: 1081 REVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSS 1140
Query: 1141 TEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRP 1200
TEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRP
Sbjct: 1141 TEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRP 1200
Query: 1201 PPTPLFGDDDDDDDIDWLG 1219
PPTPLFGDDDDDDDIDWLG
Sbjct: 1201 PPTPLFGDDDDDDDIDWLG 1219
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 107 bits (268), Expect = 5e-23
Identities = 116/476 (24%), Positives = 226/476 (47%), Gaps = 43/476 (9%)
Query: 543 HSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERN 602
HS G+S ++V +E+S + I ++ + E LKQ+ + +++EE +E+ +
Sbjct: 64 HSPGDSQY-QELAVALESSSV--TINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQ 120
Query: 603 QRYVEQSNLM-MEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTA 661
+E N++ +EK + L+T +T+ H E+E + L + ++ L+ ++A
Sbjct: 121 MEQLETINILTLEKAD--LKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSA 178
Query: 662 HQKKETE-----------LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS 710
++ E LQ +L +++KE LL +T+V L ++Q ++ K
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 711 EKQNRKQLELKV-----TSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
E+ ++ K+ T EE+ D+ +E LE++LSE K + A+ S A + +
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQE-LERSLSELKNQMAEPPSLAPPAVTSVV 297
Query: 766 KSYQEELDKLRQLLK------KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+ Q+E LRQ ++ +++V +QA LSL+ E Q Q + E +L + +
Sbjct: 298 EQLQDEAKHLRQEVEGLEGKLQSQVENNQA----LSLLSKE-QKQRLQEQEEMLREQEAQ 352
Query: 820 HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKE---LEKNKSQMSGV 876
+++ + +C Q + +++ LQE+ L+ Q L KQ E+ KE L+K + ++
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ 412
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
E E+++K ++ +L + +L++ +N K LQ L QQ +E
Sbjct: 413 EERLWKKEERLQKQEERL--ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQ-LEQQVKEL 469
Query: 937 EESSSEEEEEKAEERPRRPSQEQSASASSGQPQA--PLNRERPESPMVPSEQVVEE 990
+E EE E A +R ++ + S A G+ L+ E E+P P+ + E+
Sbjct: 470 QEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPR-PTPNIPED 524
Score = 55.8 bits (133), Expect = 2e-07
Identities = 68/349 (19%), Positives = 154/349 (44%), Gaps = 37/349 (10%)
Query: 644 ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG-------QLTKVQAKLSE 696
+LAAA ++ Q + + + + + T+S ET G Q ++ L
Sbjct: 21 KLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALES 80
Query: 697 LQETSEQAQSKFKSEKQNRKQL-----ELKVTSLE---------EELTDLRVEKESLEKN 742
T Q +S KQ +KQ+ E K T+ E E + L +EK L+
Sbjct: 81 SSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTT 140
Query: 743 LSERKKKSAQERSQAEEEIDEIRKSYQ--EELDKLRQLLKKTRVSTDQAAAEQLSLVQAE 800
L K+ + ++++ ++ S Q +EL++ + + D++++ + +++Q
Sbjct: 141 LYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRR 200
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL----VQLQEKCLALQAQITALT 856
LQ + + LL + + + ++V +RD Y + + + QE+ + + L
Sbjct: 201 LQQTIKERA--LLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLK 258
Query: 857 KQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE-LEESYNGRTILG 915
++ ++ I +++ + +S ++ ++P + V + L+ E + L + G + G
Sbjct: 259 EEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEG--LEG 316
Query: 916 TIMNTIK-MVTLQLLNQQE----QEKEESSSEEEEEKAEERPRRPSQEQ 959
+ + ++ L LL++++ QE+EE E+E ++ E+ R Q +
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNE 365
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 106 bits (265), Expect = 1e-22
Identities = 116/476 (24%), Positives = 224/476 (47%), Gaps = 43/476 (9%)
Query: 543 HSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERN 602
HS G+S ++V +E+S + I ++ + E LKQ+ + +++EE +E+ +
Sbjct: 64 HSPGDSQY-QELAVALESSSV--TINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQ 120
Query: 603 QRYVEQSNLM-MEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTA 661
+E N++ +EK + L+T +T+ H E+E + L + + L+ + A
Sbjct: 121 MEQLETINILTLEKAD--LKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCA 178
Query: 662 HQKKETE-----------LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS 710
++ E LQ +L +++KE LL +T+V L ++Q ++ K
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 711 EKQNRKQLELKV-----TSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
E+ ++ K+ T EE+ D+ +E LE++LSE K + A+ S A + +
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQE-LERSLSELKNQMAEPPSLAPPAVTSVV 297
Query: 766 KSYQEELDKLRQLLK------KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+ Q+E LRQ ++ +++V +QA LSL+ E Q Q + E +L + +
Sbjct: 298 EQLQDEAKHLRQEVEGLEGKLQSQVENNQA----LSLLSKE-QKQRLQEQEEMLREQEAQ 352
Query: 820 HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKE---LEKNKSQMSGV 876
+++ + +C Q + +++ LQE+ L+ Q L KQ E+ KE L+K + ++
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ 412
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
E E+++K ++ +L + +L++ +N K LQ L QQ +E
Sbjct: 413 EERLWKKEERLQKQEERL--ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQ-LEQQVKEL 469
Query: 937 EESSSEEEEEKAEERPRRPSQEQSASASSGQPQA--PLNRERPESPMVPSEQVVEE 990
+E EE E A +R ++ + S A G+ L+ E E+P P+ + E+
Sbjct: 470 QEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPR-PTPNIPED 524
Score = 54.7 bits (130), Expect = 5e-07
Identities = 68/349 (19%), Positives = 154/349 (44%), Gaps = 37/349 (10%)
Query: 644 ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG-------QLTKVQAKLSE 696
+LAAA ++ Q + + + + + T+S ET G Q ++ L
Sbjct: 21 KLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALES 80
Query: 697 LQETSEQAQSKFKSEKQNRKQL-----ELKVTSLE---------EELTDLRVEKESLEKN 742
T Q +S KQ +KQ+ E K T+ E E + L +EK L+
Sbjct: 81 SSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTT 140
Query: 743 LSERKKKSAQERSQAEEEIDEIRKSYQ--EELDKLRQLLKKTRVSTDQAAAEQLSLVQAE 800
L K+ + ++++ ++ S Q +EL++ + + D++++ + +++Q
Sbjct: 141 LYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRR 200
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL----VQLQEKCLALQAQITALT 856
LQ + + LL + + + ++V +RD Y + + + QE+ + + L
Sbjct: 201 LQQTIKERA--LLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLK 258
Query: 857 KQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE-LEESYNGRTILG 915
++ ++ I +++ + +S ++ ++P + V + L+ E + L + G + G
Sbjct: 259 EEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEG--LEG 316
Query: 916 TIMNTIK-MVTLQLLNQQE----QEKEESSSEEEEEKAEERPRRPSQEQ 959
+ + ++ L LL++++ QE+EE E+E ++ E+ R Q +
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNE 365
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 103 bits (256), Expect = 1e-21
Identities = 115/476 (24%), Positives = 223/476 (46%), Gaps = 43/476 (9%)
Query: 543 HSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERN 602
HS G+S ++V +E+S + I ++ + E LKQ+ + +++EE +E+ +
Sbjct: 64 HSPGDSQY-QELAVALESSSV--TISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQ 120
Query: 603 QRYVEQSNLM-MEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTA 661
+E N++ +EK + L+T +T+ H E+E + L + ++ L+ + A
Sbjct: 121 MERLETINILTLEKAD--LKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCA 178
Query: 662 HQKKETE-----------LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS 710
++ E LQ L +++KE LL +T+V L ++Q ++ K
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRWLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 711 EKQNRKQLELKV-----TSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
E+ ++ K+ T EE+ D+ +E LE++LSE K + A+ S A + +
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQE-LERSLSELKNQMAEPPSLAPPAVTSVV 297
Query: 766 KSYQEELDKLRQLLK------KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+ Q+E LRQ ++ +++V +QA LSL+ E Q Q + E +L + +
Sbjct: 298 EQLQDEAKHLRQEVEGLEGKLQSQVENNQA----LSLLSKE-QKQRLQEQEEMLREQEAQ 352
Query: 820 HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKE---LEKNKSQMSGV 876
+++ + +C Q + +++ LQE+ L+ Q L KQ E+ KE L+K + ++
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ 412
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
E E+++K ++ +L + +L++ +N K LQ L QQ +E
Sbjct: 413 EERLWKKEERLQKQEERL--ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQ-LEQQVKEL 469
Query: 937 EESSSEEEEEKAEERPRRPSQEQSASASSGQPQA--PLNRERPESPMVPSEQVVEE 990
+E EE E A + ++ + S A G+ L+ E E+P P+ + E+
Sbjct: 470 QEKLDEEHLEAASHQNQQLETQLSLVALPGEGDGGQHLDSEEEEAPR-PTPNIPED 524
Score = 55.5 bits (132), Expect = 3e-07
Identities = 73/351 (20%), Positives = 150/351 (42%), Gaps = 41/351 (11%)
Query: 644 ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG-------QLTKVQAKLSE 696
+LAAA ++ Q + + + + + T+S ET G Q ++ L
Sbjct: 21 KLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGCHSPGDSQYQELAVALES 80
Query: 697 LQETSEQAQSKFKSEKQNRKQL-----ELKVTSLE---------EELTDLRVEKESLEKN 742
T Q +S KQ +KQ+ E K T+ E E + L +EK L+
Sbjct: 81 SSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTT 140
Query: 743 LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK-TRVSTDQAAAEQLSLVQAEL 801
L K+ + EEE ++ Q L ++++L + VST Q ++ S + +
Sbjct: 141 LYHTKRAA----RHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAV 196
Query: 802 QTQW---EAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL----VQLQEKCLALQAQITA 854
+W K LL + + + ++V +RD Y + + + QE+ + +
Sbjct: 197 LQRWLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEART 256
Query: 855 LTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE-LEESYNGRTI 913
L ++ ++ I +++ + +S ++ ++P + V + L+ E + L + G +
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEG--L 314
Query: 914 LGTIMNTIK-MVTLQLLNQQE----QEKEESSSEEEEEKAEERPRRPSQEQ 959
G + + ++ L LL++++ QE+EE E+E ++ E+ R Q +
Sbjct: 315 EGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNE 365
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 102 bits (254), Expect = 2e-21
Identities = 114/476 (23%), Positives = 224/476 (47%), Gaps = 43/476 (9%)
Query: 543 HSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERN 602
HS G+S ++V +E+S + I ++ + E LKQ+ + +++EE +E+ +
Sbjct: 64 HSPGDSQY-QELAVALESSSV--TISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQ 120
Query: 603 QRYVEQSNLM-MEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTA 661
+E N++ +EK + L+T +T+ H E+E + L + ++ L+ + A
Sbjct: 121 MERLETINILTLEKAD--LKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCA 178
Query: 662 HQKKETE-----------LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS 710
++ E L +L +++KE LL +T+V L ++Q ++ K
Sbjct: 179 VSTQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 711 EKQNRKQLELKV-----TSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
E+ ++ K+ T EE+ D+ +E LE++LSE K + A+ S A + +
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQE-LERSLSELKNQMAKPPSLAPPAVTSVV 297
Query: 766 KSYQEELDKLRQLLK------KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+ Q+E LRQ ++ +++V +QA LSL+ E Q Q + E +L + +
Sbjct: 298 EQLQDEAKHLRQEVEGLEGKLQSQVENNQA----LSLLSKE-QKQRLQEQEEMLREQEVQ 352
Query: 820 HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKE---LEKNKSQMSGV 876
+++ + +C Q + +++ LQE+ L+ Q L KQ E+ KE L+K + ++
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQ 412
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
E E+++K ++ +L + +L++ +N K LQ L QQ +E
Sbjct: 413 EERLWKKEERLQKQEERL--ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQ-LEQQVKEL 469
Query: 937 EESSSEEEEEKAEERPRRPSQEQSASASSGQPQA--PLNRERPESPMVPSEQVVEE 990
+E EE E A ++ ++ + S A G+ L+ E E+P P+ + E+
Sbjct: 470 QEKLDEEHLEAASQQNQQLETQLSLVALPGEGDGGQHLDSEEEEAPR-PTPNIPED 524
Score = 51.6 bits (122), Expect = 5e-06
Identities = 73/351 (20%), Positives = 149/351 (42%), Gaps = 41/351 (11%)
Query: 644 ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG-------QLTKVQAKLSE 696
+LAAA ++ Q + + + + + T+S ET G Q ++ L
Sbjct: 21 KLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALES 80
Query: 697 LQETSEQAQSKFKSEKQNRKQL-----ELKVTSLE---------EELTDLRVEKESLEKN 742
T Q +S KQ +KQ+ E K T+ E E + L +EK L+
Sbjct: 81 SSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTT 140
Query: 743 LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK-TRVSTDQAAAEQLSLVQAEL 801
L K+ + EEE ++ Q L ++++L + VST Q ++ S + +
Sbjct: 141 LYHTKRAA----RHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAV 196
Query: 802 ---QTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL----VQLQEKCLALQAQITA 854
+ Q K LL + + + ++V +RD Y + + + QE+ + +
Sbjct: 197 LHRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEART 256
Query: 855 LTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE-LEESYNGRTI 913
L ++ ++ I +++ + +S ++ + P + V + L+ E + L + G +
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEG--L 314
Query: 914 LGTIMNTIK-MVTLQLLNQQE----QEKEESSSEEEEEKAEERPRRPSQEQ 959
G + + ++ L LL++++ QE+EE E+E ++ E+ R Q +
Sbjct: 315 EGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNE 365
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 97.4 bits (241), Expect = 7e-20
Identities = 98/490 (20%), Positives = 220/490 (44%), Gaps = 51/490 (10%)
Query: 512 ARQHNTEIRMA-VSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRI 570
A++ N E + + + + D ++ +TKVE+ +KH+ N + +++ E + + NI ++
Sbjct: 942 AKKRNLEDKCSSLKRDIDDLELTLTKVEK-EKHATENKV----KNLSEEMTALEENISKL 996
Query: 571 IQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM-------------MEKRN 617
+E + L++ + + ++ + DK++ LI+ N + +Q++ + +E+
Sbjct: 997 TKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAK 1056
Query: 618 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQ-------KKETELQ 670
L+ + +Q ++ E +K ++ E+L ++S LQ K+ Q KK ELQ
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 671 M---QLTESLKETDLLRGQLTKVQA----KLSELQETSEQAQSKFKSEKQNRKQLELKVT 723
+L E ++ LR ++ K ++ +L E+ E E+A ++ + K+ E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 724 SLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 783
+ +L + ++ E+ L +++ S E + + + +++ ++E +L+ +
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI-DDM 1235
Query: 784 VSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE-HLQQYQEVCAQRDAYQQKLVQLQ 842
S +A ++ S ++ +T + E AKDE Q ++ Q+ Q + +L
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSE---IKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREF 902
+ ++ I+ LTK + ++LE+ K QM + K K M QS R +
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQM--------EEETKAKNAMAHALQSSRHDC 1344
Query: 903 EL-----EESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQ 957
+L EE + L ++ Q + E + + + E EE K + R
Sbjct: 1345 DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1404
Query: 958 EQSASASSGQ 967
E++ ++ +
Sbjct: 1405 EENTETANSK 1414
Score = 76.3 bits (186), Expect = 2e-13
Identities = 113/565 (20%), Positives = 234/565 (41%), Gaps = 86/565 (15%)
Query: 525 KVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR---IIQENERLKQEI 581
++ +KM L+ + +LQ + V ET +M +R +I+ L+ ++
Sbjct: 876 ELEEKMVSLLQEKNDLQ------------LQVQSETENLMDAEERCEGLIKSKILLEAKV 923
Query: 582 LEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAK- 640
E + R+EE+ + SEL+ + + ++ + + ++ T T+ + + HA + K K
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEK--HATENKVKN 981
Query: 641 VTEELAAATAQVSHLQLK----MTAHQKKETELQMQ--------------------LTES 676
++EE+ A +S L + AHQ+ +LQ++ L S
Sbjct: 982 LSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS 1041
Query: 677 LKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL--RV 734
L++ LR L + + KL + S+++ +++KQ Q+E K+ E EL+ L ++
Sbjct: 1042 LEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ---QIEEKLKKKEFELSQLQAKI 1098
Query: 735 EKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTDQAAAE 792
+ E + ++K K Q R + EE E + + +++K R L + +S A
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS 1158
Query: 793 QLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQI 852
+ Q E+ + EA+ + + ++ LQ R + +L E+ LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218
Query: 853 TALTKQNEQ----------HIKELEKNKSQMSGVEAAASDPSEKVK---KIMNQVFQSLR 899
L K+ + +I+ L K+KS + D ++K + Q+ L
Sbjct: 1219 QKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLN 1278
Query: 900 REFELEESYNG---------RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEE 950
+ ++ NG +++ + + + +T QL + Q +EE+ ++ A +
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 951 RPRRP--------SQEQSASASSGQPQAPLN------RERPESPMVPSEQVVEEAVPLPP 996
R +EQ A A + + N R + E+ + + +EEA
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 997 QALTTSQDGHRRKGDSEAEALSEIK 1021
Q L +++ + +S+ +L + K
Sbjct: 1399 QRLQEAEE-NTETANSKCASLEKTK 1422
Score = 66.6 bits (161), Expect = 1e-10
Identities = 89/431 (20%), Positives = 175/431 (40%), Gaps = 48/431 (11%)
Query: 539 ELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISEL 598
ELQ+ + + + ET I + + + ++L Q + E E N K + L
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEENTETANSKCASL 1418
Query: 599 IERNQRYV-EQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQL 657
+ QR E +LM + + AT ++++ + LA ++ Q
Sbjct: 1419 EKTKQRLQGEVEDLMRDLERSHTACAT---------LDKKQRNFDKVLAEWKQKLDESQA 1469
Query: 658 KMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQ 717
++ A QK+ L +L + + + QL ++ + LQE + +N ++
Sbjct: 1470 ELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE 1529
Query: 718 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQ---ERSQAEEEIDEIRKSYQEELDK 774
E +E+E +DL+V E +E +L + K + E SQ + E+D EE+++
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 775 LRQLLKKTRVSTDQAAAEQL-SLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDA 833
L++ Q AAE L S++ AE++++ +A K + E+ Q
Sbjct: 1590 LKR--------NSQRAAEALQSVLDAEIRSRNDA------LRLKKKMEGDLNEMEIQLGH 1635
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVE-------------AAA 880
+++ + Q+ +Q Q+ + ++ E K Q++ VE A
Sbjct: 1636 SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA 1695
Query: 881 SDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLN-QQEQEKEES 939
+ +E+ +++ Q +L S N +++NT K + + Q E E
Sbjct: 1696 LEQTERTRRLSEQELLDASDRVQLLHSQN-----TSLINTKKKLEADIAQCQAEVENSIQ 1750
Query: 940 SSEEEEEKAEE 950
S EEKA++
Sbjct: 1751 ESRNAEEKAKK 1761
Score = 65.9 bits (159), Expect = 2e-10
Identities = 73/408 (17%), Positives = 167/408 (40%), Gaps = 52/408 (12%)
Query: 514 QHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQE 573
Q +++++A+ +V ++H +K+ + V +E S + S + R + E
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKI----------------LRVQLELSQVKSELDRKVIE 1582
Query: 574 NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLH 633
+ +++ S R E + + R++ + ME N ++ ++ H
Sbjct: 1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI-------QLGH 1635
Query: 634 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAK 693
+ ++ A+ + L Q+ QL + + +L+ QL + LL +L +++
Sbjct: 1636 SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA 1695
Query: 694 LSELQETSEQAQSKFKSEKQNRKQLELKVTSL-------EEELTDLRVEKESL---EKNL 743
L + + T ++ + + L + TSL E ++ + E E+ +N
Sbjct: 1696 LEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
Query: 744 SERKKKSAQERSQAEEEI-----------------DEIRKSYQEELDKLRQLLKKTRVST 786
E+ KK+ + + EE+ ++ K Q LD+ QL K
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1815
Query: 787 DQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCL 846
Q ++ ++ EL + + E L + K E ++ +E+ Q + + +++LQ+
Sbjct: 1816 IQKLENRVRELENELDVEQKRGAEALKGAHKYE--RKVKEMTYQAEEDHKNILRLQDLVD 1873
Query: 847 ALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV 894
LQA++ + +Q E+ ++ S+ V+ + +E+ +QV
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Score = 63.9 bits (154), Expect = 9e-10
Identities = 90/496 (18%), Positives = 211/496 (42%), Gaps = 38/496 (7%)
Query: 550 LIPSMSVTMETSMIMSNIQRIIQE---NERLKQEILEKS-NRIEEQND-------KISEL 598
L+ S E + + + +R +E +E ++E+ EK + ++E+ND + L
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 599 IERNQRY--VEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 656
++ +R + +S +++E + L E + +K + ++ ++ + L+
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 657 LKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 716
L +T +K++ + ++ +E L ++K+ + LQE +Q + E+
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 717 QLELKVTSLEEELTDLR---VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELD 773
L LE++ DL +++ L +L K+K + ++E I ++ Q+ +
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEE 1082
Query: 774 KLRQLLKKTRVSTDQAAAEQLSLVQAELQ---TQWEAKCEHLLASAKDEHLQQYQEVCAQ 830
KL++ K+ +S QA + + + Q + +A+ E L + EH + ++ Q
Sbjct: 1083 KLKK--KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR-AKIEKQ 1139
Query: 831 RDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGV----EAAAS----D 882
R ++L ++ E+ +A + N++ E +K + + EA A+
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 883 PSEKVKKIMNQV--FQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESS 940
++ V ++ Q+ Q ++++ E E+S I N ++ L++ + E +
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASN------IEALSKSKSNIERTC 1253
Query: 941 SEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALT 1000
E++ +E + + Q Q + Q + S V ++ + + QALT
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 1001 TSQDGHRRKGDSEAEA 1016
+ +R+ + E +A
Sbjct: 1314 QQLEELKRQMEEETKA 1329
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/260 (18%), Positives = 110/260 (42%), Gaps = 6/260 (2%)
Query: 601 RNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMT 660
R+ +++ ++E+RN L E + + E+ + +EL A+ +V L + T
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNT 1725
Query: 661 AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL 720
+ + +L+ + + E + + + K + + + K E+ LE
Sbjct: 1726 SLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 721 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERS----QAEEEIDEIRKSYQEELDKLR 776
+LE+ + DL+ + E+ + KK Q+ + E E+D +K E L
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH 1845
Query: 777 QLLKKTRVSTDQAAAEQLSLVQ-AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQ 835
+ +K + T QA + ++++ +L + +AK + A++ Q ++ R Q
Sbjct: 1846 KYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR-RVQ 1904
Query: 836 QKLVQLQEKCLALQAQITAL 855
+L + E+ ++Q+ L
Sbjct: 1905 HELEEAAERADIAESQVNKL 1924
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 89.7 bits (221), Expect = 1e-17
Identities = 109/499 (21%), Positives = 220/499 (44%), Gaps = 51/499 (10%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET--SMIMSNIQRIIQENE 575
++++A + + T++EE K A +S ++ T+ + ++ + QR+ + +
Sbjct: 344 DLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED 403
Query: 576 RLK---QEILEKSNRIEEQ----NDKISELIERNQRYVEQSNLMME-KRNNSLQTATENT 627
+LK E+ +KS+ +EE N+K EL E + E+ L+ E K+ + + T
Sbjct: 404 QLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGT 463
Query: 628 QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQL-TESLKETDLLRGQ 686
+ ++ Q + K +L Q++ + + K+ +L+ +L E LK T+L
Sbjct: 464 EQELIGLLQAREKEVHDLEI---QLTAITTSEQYYSKEVKDLKTELENEKLKNTELT-SH 519
Query: 687 LTKVQAKLSEL-QETSEQA------QSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL 739
K+ + EL QETS+ Q + K+ +++ ++ +L+E T LR E E +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 740 EKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQA 799
+ L +++ + + ++EE + +RK + + + +L ++ + + AE L
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVY 639
Query: 800 ELQTQWEAKCEHLLASAKD---EHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALT 856
E++ K E L SAK E YQ+ + ++ L++ EK + + L
Sbjct: 640 EIKVN---KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 857 KQNE---QH-----IKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
K+ + QH + +EK+K Q + D + K Q SLR E+E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKI-IEERDSELGLYKSKEQEQSSLRASLEIE--- 752
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
++ +K L + Q E E+EE E+ + +A+E +++ +
Sbjct: 753 ---------LSNLKAELLSVKKQLEIEREE--KEKLKREAKENTATLKEKKDKKTQTFLL 801
Query: 969 QAPLNRERPESPMVPSEQV 987
+ P + +S VPS+ V
Sbjct: 802 ETPEIYWKLDSKAVPSQTV 820
Score = 70.5 bits (171), Expect = 9e-12
Identities = 124/610 (20%), Positives = 248/610 (40%), Gaps = 80/610 (13%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERL 577
E++ KV+ K++ + + ++L K + L + T S ++ E E
Sbjct: 150 ELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSA--EKTKKYEYEREET 207
Query: 578 KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQE 637
+Q ++ +N IE+ EL V+ N +E + + ++ H EQE
Sbjct: 208 RQVYMDLNNNIEKMITAFEEL------RVQAENSRLE-----MHFKLKEDYEKIQHLEQE 256
Query: 638 KAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSEL 697
K E+ QVS L +++T + K +L L ES + K+++L
Sbjct: 257 YKK---EINDKEKQVSLLLIQITEKENKMKDLTFLLEES--------------RDKVNQL 299
Query: 698 QETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVE-------KESLEKNLSERKKKS 750
+E K K + +N KQ K L +EL D++V +++LE++L K
Sbjct: 300 EE-------KTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 751 AQERSQAEEEIDEIRKS----------YQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAE 800
Q + E +++E K+ ++ + L +LL +T + +QL ++ E
Sbjct: 353 CQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELL-RTEQQRLEKNEDQLKILTME 411
Query: 801 LQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDA--YQQK-LVQLQEKCLALQAQITAL 855
LQ + ++ E + L + K+ L++ ++V +++ Y+ K ++ E+ + ++ L
Sbjct: 412 LQKK-SSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 856 TKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILG 915
+ E+ + +LE Q++ + + S++VK + ++ + EL N ++
Sbjct: 471 LQAREKEVHDLE---IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLEN 527
Query: 916 -TIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNR 974
+ +TL+L NQQE EE K E + + + + R
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 975 ERPESPMVPSEQVVE------EAVPLPPQALTTSQDGHRRKGDSEAEALS--EIKDGSLP 1026
+ + + SE+ E + L ++KG +E++ L+ EIK L
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKL- 646
Query: 1027 PELSCIPSHRVLGPPT-----SIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVR 1081
EL + + G T I + + ++ E E++ + A K K C
Sbjct: 647 -ELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQH 705
Query: 1082 EVAPDGPLQE 1091
++A L E
Sbjct: 706 KIAEMVALME 715
Score = 45.1 bits (105), Expect = 4e-04
Identities = 82/406 (20%), Positives = 170/406 (41%), Gaps = 50/406 (12%)
Query: 575 ERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHA 634
E LK LE S + K+ + E+ +++ + + ++ + LQ EN +++ A
Sbjct: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQ---ENR--KIIEA 143
Query: 635 EQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKL 694
++ K +EL +VS L+L+ + K+ + T L +LL+ + K
Sbjct: 144 QR---KAIQELQFGNEKVS-LKLEEGIQENKDLIKENNATRHL--CNLLKETCARSAEKT 197
Query: 695 SELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKES----LEKNLSERKKKS 750
+ + E+ + + N +E +T+ EE LRV+ E+ + L E +K
Sbjct: 198 KKYEYEREETRQVYMDLNNN---IEKMITAFEE----LRVQAENSRLEMHFKLKEDYEKI 250
Query: 751 AQERSQAEEEIDEIRKSY----------QEELDKLRQLLKKTRVSTDQAAAEQLSLVQAE 800
+ ++EI++ K + ++ L LL+++R +Q E+ + +Q+E
Sbjct: 251 QHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ--LEEKTKLQSE 308
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE 860
Q K HL +D + + V Q+ + + + C + + T + + N+
Sbjct: 309 NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNK 368
Query: 861 ---QHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV----FQSLRREFELEESYNGRTI 913
H + + ++ + +E ++++K +Q+ + ++ ELEE
Sbjct: 369 ARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM------ 422
Query: 914 LGTIMNTIKMVTLQLLNQQEQEKEESSSEEEE-EKAEERPRRPSQE 958
T + K V L+ L + EKE E ++ EK E + QE
Sbjct: 423 --TKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQE 466
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 89.0 bits (219), Expect = 3e-17
Identities = 104/474 (21%), Positives = 216/474 (45%), Gaps = 49/474 (10%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSML-IPSMSVTMETSMIMSNI 567
+ + RQ NT++ + ++++ ++ E++K ++ L + S +E+ I +
Sbjct: 753 LQQQRQLNTDLELRATELSKQL--------EMEKEIVSSTRLDLQKKSEALES--IKQKL 802
Query: 568 QRIIQENERLKQ--EILEKSNRI--EEQNDKISELIERNQRY-VEQSNLMME-----KRN 617
+ +E + LKQ E L + +I EE N++I + Q+ +E+ LM E +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 618 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSH-LQLKMTAHQKKETELQMQLTES 676
+ + + +N+++ Q+ +L ++ H LQ++M K++ EL+ L +
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 677 LKETDLLRGQLTKVQAKLSELQET-------SEQAQSKFKSEKQNRKQLELKVTSLEEEL 729
+ + L+ +L +Q +L + Q T +Q Q KQ+ +Q + ++ +L+ EL
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Query: 730 TDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD 787
++K LE L ++ ++AQE + +E+I ++ +Y++ + +QL R S
Sbjct: 983 KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Query: 788 QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQ----KLVQLQE 843
A + L V+ +L E + L QE+ + +Q K QLQE
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL--IQELKTAKATLEQDSAKKEQQLQE 1100
Query: 844 KCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV----FQSLR 899
+C ALQ + K+ KEL KS+++ +E +++ K+ ++ +S++
Sbjct: 1101 RCKALQ----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 900 REFELEES----YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAE 949
L+++ + L +++K Q Q+ K++ EEEE K E
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
Score = 84.7 bits (208), Expect = 5e-16
Identities = 86/415 (20%), Positives = 183/415 (44%), Gaps = 40/415 (9%)
Query: 577 LKQEILEKSNRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTATENTQARVLH 633
L+ + E ++++ E +K+S+L I+ + + + LQ + Q +
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 634 AEQEKAKVTEELAAATAQVSHLQ---LKMTAHQKKETELQMQLTESLKETDLLRGQLTKV 690
+QE K+T +L TA++ Q ++ +H K+ E + L + +E L GQ+ K+
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE---LEGQIKKL 735
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKS 750
+A E++ + EQA + ++Q LEL+ T L ++ L +EKE + + +KKS
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ---LEMEKEIVSSTRLDLQKKS 792
Query: 751 ------AQERSQAEEEIDEIRKSYQ--EELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQ 802
Q+ ++ EEE +++ ++ + K++ R+ T +++ + + L
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 803 TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCL----ALQAQITALTKQ 858
T+ + + L+ D E + + ++ L++ C LQ Q+ K+
Sbjct: 853 TEL-STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN--------G 910
++ K LEK K ++ + E++ + N + Q+ + E +L+ + N
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 911 RTILGTIMNTIKMVTLQ-------LLNQQEQEKEESSSEEEEEKAEERPRRPSQE 958
+ + + +K+ LQ L Q Q +E ++E+E+ + SQE
Sbjct: 972 KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Score = 82.0 bits (201), Expect = 3e-15
Identities = 114/516 (22%), Positives = 227/516 (43%), Gaps = 59/516 (11%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L A Q T + ++K A + L K E LQ+ + ++ V ++T M +
Sbjct: 185 LREAAEQKVTRLTEELNKEATVIQDL--KTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTAT 624
+R +E+E+LK E + ++ IS+L + + + V ++K +S+ T
Sbjct: 243 ERE-RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT 301
Query: 625 ENTQA---RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETD 681
+ Q +L EQ+ K+ E+ + VS ++ T HQK Q+Q S ET
Sbjct: 302 QKNQTLTENLLKKEQDYTKLEEKHNEES--VSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 682 LLR--------GQLT-KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL 732
L R G+ T K++ +LSE++ + +++FK +Q R++ E L+ E+ L
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 733 RVEKESLEKNLSERKKKSAQERSQAEEEI---DEIRKSYQEELDKLRQLLKKTRVSTDQA 789
+ E+ L E + ++R + E++ ++ Q +L +L + LK+ +V+
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE-KVTNSTE 478
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
QL + + Q Q +A + A ++ AQ D +Q L Q+ +K +Q
Sbjct: 479 LQHQLDKTKQQHQEQ-QALQQSTTAKLRE----------AQND-LEQVLRQIGDKDQKIQ 526
Query: 850 AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN 909
+ AL ++++++I LEK + + A E ++NQ L+E +
Sbjct: 527 -NLEALLQKSKENISLLEKEREDL----YAKIQAGEGETAVLNQ----------LQEKNH 571
Query: 910 GRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ--SASASSGQ 967
T+ + +T +L NQ E K+ + ++ + ++ R +Q++ S S +
Sbjct: 572 ------TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 968 PQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ 1003
+ LN + + + + + + L +A T+Q
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Score = 81.3 bits (199), Expect = 5e-15
Identities = 117/514 (22%), Positives = 225/514 (43%), Gaps = 87/514 (16%)
Query: 517 TEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET--SMIMSNIQRIIQEN 574
TE+ K++ D L E +K + I + T + + ++ ++E
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 575 ERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHA 634
+ LK+ LEK Q EL ++ ++ N + K+N + + + +
Sbjct: 913 KELKKS-LEKEKEASHQLKL--ELNSMQEQLIQAQNTL--KQNEKEEQQLQGNINELKQS 967
Query: 635 EQEKAKVTEELAAATAQVSHLQLKMTAHQKKETE--LQMQLTESLKETDLLRGQLTKVQA 692
++K K E L +LK+ QK E E LQ QLT++ +E + +++ +Q
Sbjct: 968 SEQKKKQIEALQG--------ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 693 KLSELQETSEQAQSKF---KSE----KQNRKQLELKVTSLEEELT--------------D 731
+ QET +Q QS F +SE +Q+ K +E K++ +E+L +
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
Query: 732 LRVEKESLEKN-------LSER--------KKKSAQERSQAEE-----EIDEIRKSYQEE 771
L+ K +LE++ L ER K+KS +E+ E EI+EI+ ++E
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 772 LDKLRQLLKKTRVS-----TDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQE 826
+ KL + LK ++ T+ A+QL L+Q +L+ Q K + L A+ + E Q
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQL-LIQQKLELQ--GKADSLKAAVEQEKRNQQ-- 1194
Query: 827 VCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEK 886
+D +++ +L+++ + +A++ + K+ E +K+ E+N+++++ A ++
Sbjct: 1195 --ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 887 VKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQE--------KEE 938
VKK + S RR ELE+ + + I ++ + N Q++ K E
Sbjct: 1253 VKK---EWQSSQRRVSELEKQTD------DLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
Query: 939 SSSEEEEEKAEERPRRPSQEQSASASSGQPQAPL 972
E+ + K E R+ +A G+ L
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
Score = 66.6 bits (161), Expect = 1e-10
Identities = 97/520 (18%), Positives = 212/520 (40%), Gaps = 76/520 (14%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQ 568
+ E RQ ++E M + + ++++EE K NS E + +
Sbjct: 437 LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNST---------ELQHQLDKTK 487
Query: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS---LQTATE 625
+ QE + L+Q K + +++ I + ++ +++K + L+ E
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 626 NTQARVLHAEQEKA---KVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL 682
+ A++ E E A ++ E+ QV+ L K+ + + Q L + ++E
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ-- 605
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
+ L Q ++ L+ + + S+ K+ QL++++ + E L K + +
Sbjct: 606 -KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 743 LSERK-------KKSAQERSQAEEEIDEIRKSYQEELDKLRQL------LKKTRVSTDQA 789
L + QE ++ ++D++ Q++ + QL K+ +S +Q
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 790 AAE---QLSLVQA--------------ELQTQWEAKCE-HLLASAKDEHLQQYQEVCAQR 831
E Q+ ++A +LQ Q + + L A+ + L+ +E+ +
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 832 -----------DAYQQKLVQLQEKCLALQAQITALTKQNE-QH----------IKELEKN 869
++ +QKL + +E+ L+ L+++ + QH + EL+K
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 870 KSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLL 929
K + + S +K+ K+ + + S + EFE +E+ G+ + + T K + QL
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNS-KSEFE-KENQKGKAAILDLEKTCKELKHQLQ 902
Query: 930 NQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQ 969
Q E +E ++E +K+ E+ + S + +S Q Q
Sbjct: 903 VQMENTLKE---QKELKKSLEKEKEASHQLKLELNSMQEQ 939
Score = 60.8 bits (146), Expect = 7e-09
Identities = 75/328 (22%), Positives = 152/328 (46%), Gaps = 44/328 (13%)
Query: 571 IQENERLKQE-ILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQA 629
++E L QE ++ N+I QN I EL + + +EQ + E++ A ++ Q
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQEL-KTAKATLEQDSAKKEQQLQERCKALQDIQ- 1109
Query: 630 RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLT----ESLKE-TDLLR 684
+EK+ +EL ++++ ++ +K+ T+L +L ES+KE T+L
Sbjct: 1110 ------KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL----- 739
+ +Q KL ELQ ++ ++ + EK+N++ L+ +V EEEL +EKE+
Sbjct: 1164 AKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
Query: 740 ------EKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
K E + K + + E + ++K +Q ++ +L K+ TD E
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ----TDDLRGE- 1277
Query: 794 LSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQIT 853
+++++A +Q + + L K E + + Q K+++LQ K A +
Sbjct: 1278 IAVLEATVQNNQDERRALLERCLKGE---------GEIEKLQTKVLELQRKLDNTTAAVQ 1328
Query: 854 ALTKQNE----QHIKELEKNKSQMSGVE 877
L ++N+ +H + L + ++ + V+
Sbjct: 1329 ELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/384 (20%), Positives = 165/384 (42%), Gaps = 32/384 (8%)
Query: 608 QSNLMMEKRNNSL-QTATENTQARVLHAE---QEKAKVTEELAAATAQVSHLQLKMTAHQ 663
+SNL +++ + +L + ++ QA + + +E K E+ Q + +T
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 664 KKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVT 723
+ L+ QL E+ E ++ + K ++L +SK+ E+ R+ E KVT
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 724 SLEEELTDLRVEKESLEKNLSERK-----KKSAQERSQAEEEIDEIRKSYQEELDKLRQL 778
L EEL + L+ L +R +E Q + +D + + E +KL+
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 779 LKK--TRVSTDQAAAEQLSLVQAELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAY 834
KK ++ ++ +A QL A+ + + L L S+ +E Q+ Q +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 835 QQKLVQLQEKCLALQAQITALTKQNEQHIKEL--EKNKSQMSGVEAA----------ASD 882
+Q +L+EK + ++ Q H K+L ++ +S++S E + +
Sbjct: 315 EQDYTKLEEK--HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 883 PSEKVKKIMNQV---FQSLRREF-ELEESYNGRTILG-TIMNTIKMVTLQLLNQQEQEKE 937
++K+K+ +++V +Q L+ EF +L++ + G + + I + +LL + Q E
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 938 ESSSEEEEEKAEERPRRPSQEQSA 961
+E+ + ++Q A
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVA 456
Score = 48.1 bits (113), Expect = 5e-05
Identities = 61/285 (21%), Positives = 110/285 (38%), Gaps = 41/285 (14%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKH-SAGNSMLIPSMSVTMETSMIMSN 566
L+ E + + +K ++ ++++QK S L+ S E I
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135
Query: 567 IQRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
++ I + NE LK LE I D LI Q L ++ + +SL+ A E
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLI--------QQKLELQGKADSLKAAVE 1187
Query: 626 NTQARVLHAEQEKAKVTEEL--------AAATAQVSHLQLKMTAHQKKETELQMQLT--- 674
+ + + K EEL A +++ ++ M H++ E +L MQ+T
Sbjct: 1188 QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALN 1247
Query: 675 ------------------ESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 716
E K+TD LRG++ ++A + Q+ + + +
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 717 QLELKVTSLEEEL--TDLRVEKESLEKNLSERKKKSAQERSQAEE 759
+L+ KV L+ +L T V++ E + K A R AE+
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAED 1352
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 88.6 bits (218), Expect = 3e-17
Identities = 71/366 (19%), Positives = 171/366 (46%), Gaps = 40/366 (10%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRI 570
E ++ N +++ + V + + V+EL++ +L+P + E + +Q +
Sbjct: 206 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 265
Query: 571 -------IQENE--------------RLKQEILEKSNRIEEQNDKISELIERNQRYVE-- 607
++ENE R +++I E+ +I+EQ +KI E E+ +R E
Sbjct: 266 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 608 ---------QSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLK 658
Q +M EK ++ E + EQE+ + EE + + K
Sbjct: 326 WEKEEKMRRQEEMMWEKEEK-IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Query: 659 MTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQL 718
M ++K E + ++ E + ++ + + K+ E +E ++ + K + +++ ++
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 719 ELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQL 778
E K+ EE++ + + E+ + E++ K ++ ++ +E+ +++R+ QEE K+R+
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR--QEE--KIREQ 500
Query: 779 LKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL 838
KK R ++ EQ ++Q + + WE E + +++ +Q +++ Q + +++
Sbjct: 501 EKKIR-EQEEKIREQEEMMQEQEEKMWEQ--EEKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Query: 839 VQLQEK 844
V+L+++
Sbjct: 558 VRLRQQ 563
Score = 78.6 bits (192), Expect = 3e-14
Identities = 84/448 (18%), Positives = 200/448 (44%), Gaps = 52/448 (11%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERL 577
E+ A+S VA + +EEL K S+ + ++T E + ++N +L
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE---------ELKEKNAKL 214
Query: 578 KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQE 637
+ EK +E + +I ++ +R +E++ L++ + + QA H +E
Sbjct: 215 Q----EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ---------QQLQAEADHLGKE 261
Query: 638 KAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKV---QAKL 694
V+ +L A QV +L +Q++E ++ Q + + + ++ Q K+ + K+
Sbjct: 262 LQSVSAKLQA---QVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKM 318
Query: 695 SELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQER 754
+E + + K + +++ + E K+ LEE++ + +E EK E K + ++R
Sbjct: 319 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 378
Query: 755 SQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLA 814
+ E ++ + +E+ +K+R+ ++ EQ + + + WE
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIRE--------QEEMMQEQEEKMGEQEEKMWE-------- 422
Query: 815 SAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMS 874
++E +Q+ +E +++ +K+ + ++K + +I + ++ +++ + + +M
Sbjct: 423 --QEEEMQEQEEKMRRQE---EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 875 GVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQE- 933
EA + EK+++ ++ + ++ E EE + + + + +QE
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 934 --QEKEESSSEEEEEKAEERPRRPSQEQ 959
QE+EE +EE+ E+ R QE+
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Score = 65.1 bits (157), Expect = 4e-10
Identities = 91/467 (19%), Positives = 203/467 (43%), Gaps = 28/467 (5%)
Query: 572 QENERLKQEILEKSNRIEE---QNDKISELIERNQRYVEQ----SNLMMEKRNNSLQTAT 624
Q E L++E+ + I Q ++ + +Q V+Q + ++ + ++S + A
Sbjct: 104 QHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAG 163
Query: 625 ENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
E QA A Q+K K + T + L L++ + + EL+ + + ++ L+
Sbjct: 164 ELEQALSAVATQKK-KADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 222
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL--RVEKESLEKN 742
+ +++Q + EL+ E+A+ + QL+ + L +EL + +++ + E
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQ-----QLQAEADHLGKELQSVSAKLQAQVEENE 277
Query: 743 LSERKKKSAQERS-QAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQA-AAEQLSLVQAE 800
L R + +E+ + EE+I E + QE+ +K+R+ +K R + E+ Q E
Sbjct: 278 LWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 337
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQK-LVQLQEKCLALQAQITALTKQN 859
+ + E K L +E + + +++ Q + Q++ ++ QEK +A++ ++
Sbjct: 338 MMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392
Query: 860 EQHIKELEKNKSQMSGVEAAASDPSEKV---KKIMNQVFQSLRREFEL--EESYNGRTIL 914
+ +++ + + M E + EK+ ++ M + + +RR+ E E+ R
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE 452
Query: 915 GTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNR 974
I +M+ Q EQE + E + ++ EE+ RR ++ + Q R
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 975 ERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEIK 1021
E+ E E++ E+ + Q + + + E E++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVR 559
Score = 62.8 bits (151), Expect = 2e-09
Identities = 94/440 (21%), Positives = 183/440 (41%), Gaps = 54/440 (12%)
Query: 597 ELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 656
E + R Q+ ++ + LQ A +Q V E E + L + L+
Sbjct: 107 EALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELE 166
Query: 657 LKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRK 716
++A ++ + + E KE D L +L + EL+E + + Q K + + +
Sbjct: 167 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 226
Query: 717 QLELKVTSLEEELT---------DLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKS 767
+++L V L+ +L L+ E + L K L + SA+ ++Q EE R +
Sbjct: 227 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---QSVSAKLQAQVEENELWNRLN 283
Query: 768 YQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQE 826
Q+E RQ K + R Q E++ + +++ Q E E K+E +++ +E
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE------KEEKMRRQEE 337
Query: 827 VCAQRDAYQQKLVQLQEKCLALQAQITALT--KQNEQHIKELEKNKSQMSGVEAAASDPS 884
+ +++ +K+ +L+EK + Q +I +Q E+ I+E EK + Q EA
Sbjct: 338 MMWEKE---EKIRELEEK-MHEQEKIREQEEKRQEEEKIREQEKRQEQ----EAKMWRQE 389
Query: 885 EKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEE 944
EK+++ ++ + E EE EQE++ EEE
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMG-----------------------EQEEKMWEQEEE 426
Query: 945 EEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ--ALTTS 1002
++ EE+ RR ++ + Q RE+ E E++ E+ + Q +
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486
Query: 1003 QDGHRRKGDSEAEALSEIKD 1022
++ RR+ + E +I++
Sbjct: 487 EEKMRRQEEKIREQEKKIRE 506
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/358 (21%), Positives = 157/358 (43%), Gaps = 54/358 (15%)
Query: 609 SNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLK-MTAHQKKET 667
S+ +K NN T E T + H+ +++ K + + A + Q++ + ++T
Sbjct: 71 SDTKKKKINNG--TNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKT 128
Query: 668 ELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEE 727
ELQM L S L G+ + ++L + + + + + + +K+ + + L +
Sbjct: 129 ELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 188
Query: 728 ELTDLRVE---KESLEKNLSERKKKSAQERSQAEEEIDEIR---KSYQEELDKLRQLLKK 781
E L +E ++ L E+ K ++ E E EI+ K + +L++ + LL +
Sbjct: 189 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ 248
Query: 782 TRVSTD-QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ 840
++ + ++L V A+LQ Q E E+ L + ++ QQ +++ Q + Q++ +
Sbjct: 249 QQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQ--QQEEKMWRQEEKIQEREEK 303
Query: 841 LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR 900
+QE+ ++ Q + +Q E ++ EK + Q E + EK++
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ----EEMMWEKEEKIR------------ 347
Query: 901 EFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQE 958
ELEE +++QE+ +E+ +EEEK E+ +R QE
Sbjct: 348 --ELEEK---------------------MHEQEKIREQEEKRQEEEKIREQEKRQEQE 382
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 86.3 bits (212), Expect = 2e-16
Identities = 98/486 (20%), Positives = 217/486 (44%), Gaps = 70/486 (14%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRI 570
E ++ N +++ + V + + V+EL++ +L+P + E + +Q +
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 571 -------IQENE--------------RLKQEILEKSNRIEEQNDKISE----LIERNQRY 605
++ENE R +++I E +I+EQ +KI E + E+ ++
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 606 VEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKK 665
Q +M EK + Q ++ ++EK + EE+ + Q +M +K
Sbjct: 338 RRQEEMMWEKEEKMRR------QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM--WEK 389
Query: 666 ETELQMQLTESLKETDLLRGQLTKVQA--KLSELQETSEQAQSKFKSEKQNRKQLELKVT 723
E +++ +L E + E + +R Q K Q K+ E ++ EQ ++ E++ R+Q E K+
Sbjct: 390 EEKIR-ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE-KIR 447
Query: 724 SLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 783
E+++ + EK E K++ +E + EE+I E + ++++ +K+ + +K R
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK-EKMHEQEEKIR 506
Query: 784 VSTDQA------AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDA-YQQ 836
++ EQ ++ + + W ++E +++ +E+ + + ++Q
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWR----------QEEKIREQEEMWREEEKMHEQ 556
Query: 837 KLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQ 896
+ + +EK Q Q + +Q E+ ++ EK Q + E+ +K+ Q +
Sbjct: 557 EKIWEEEK---RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK 613
Query: 897 SLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQE--QEKEESSSEEEEEKAEERPRR 954
+E +++E I+ ++ Q+E QE+EE E+EE+ E+ +
Sbjct: 614 IREQEEKIQEQEE----------KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 663
Query: 955 PSQEQS 960
QE++
Sbjct: 664 QEQEET 669
Score = 76.3 bits (186), Expect = 2e-13
Identities = 95/508 (18%), Positives = 218/508 (42%), Gaps = 42/508 (8%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVT-METSMIMSNIQRIIQENER 576
E+ A+S VA + +EEL K S+ + ++T E + +Q +Q E
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 577 LKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS--LQTATENTQA--RVL 632
K EI ++ + ++ L+ + Q E +L E ++ S LQ E + R+
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 633 HAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQA 692
++EK EE ++ + K+ ++K E + ++ E ++ + + +
Sbjct: 296 QQQEEKMWRQEE------KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 693 KLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKK-KSA 751
K+ +E + + K + +++ + E K+ EE + + + LE+ + E++K +
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 752 QERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEH 811
+E+ Q EE+I E K ++E RQ ++ EQ ++ + + W
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQ---------EEKIREQEEKIREQEKKMWR----- 455
Query: 812 LLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKS 871
++E + + +++ + +Q+ + QE+ + Q +I ++ + +++ K +
Sbjct: 456 -----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 872 QMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ 931
++ E + EK+++ ++++ + E EE + M+ + + + Q
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE----EKMHEQEKIWEEEKRQ 566
Query: 932 QEQEK---EESSSEEEEEKA---EERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSE 985
++++K +E E+EEK EE+ R +++ Q RE+ E E
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 986 QVVEEAVPLPPQALTTSQDGHRRKGDSE 1013
++ E+ + Q T Q+ + G+ E
Sbjct: 627 KIREQEEKIREQEEMT-QEQEEKMGEQE 653
Score = 63.5 bits (153), Expect = 1e-09
Identities = 78/365 (21%), Positives = 166/365 (45%), Gaps = 33/365 (9%)
Query: 609 SNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ---LKMTAHQKK 665
S+ +K NN T E T + H+ +++ K + + A + Q +++ QK
Sbjct: 83 SDTKKKKINNG--TNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQK- 139
Query: 666 ETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSL 725
TELQM L S L G+ + ++L + + + + + + +K+ + + L
Sbjct: 140 -TELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEEL 198
Query: 726 EEELTDLRVE---KESLEKNLSERKKKSAQERSQAEEEIDEIR---KSYQEELDKLRQLL 779
+E L +E ++ L E+ K ++ E E EI+ K + +L++ + LL
Sbjct: 199 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 258
Query: 780 KKTRVSTD-QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL 838
+ ++ + ++L V A+LQ Q E E+ L + L Q QE R ++K+
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWN----RLNQQQEEKMWRQ--EEKI 309
Query: 839 VQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSL 898
+ +EK + +I ++ E+ I+E E+ + + + + +++M + + +
Sbjct: 310 QEWEEKIQEQEEKI----REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365
Query: 899 RREFEL-----EESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPR 953
RR+ E+ E+ ++ I+ + + +++QE+ +E+ +EEEK E+ +
Sbjct: 366 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEK 424
Query: 954 RPSQE 958
R QE
Sbjct: 425 RQEQE 429
Score = 51.2 bits (121), Expect = 6e-06
Identities = 58/323 (17%), Positives = 145/323 (44%), Gaps = 23/323 (7%)
Query: 513 RQHNTEIRMAVSKV--ADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRI 570
R+ +IR K+ ++ H K+ E +K M + + + +
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 571 IQENERLKQE--ILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQ 628
QE + KQE + + +I EQ +KI E E+ R E+ + ++ + + +
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK----IREQEEMWREEEKMHE 555
Query: 629 ARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKK----ETELQMQLTESLKETDLLR 684
+ E+++ + +++ ++ + K+ ++K E + Q Q + K+ + +R
Sbjct: 556 QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQL---ELKVTSLEEELTDLRVEKESLEK 741
Q K+Q + +++E E+ + + + ++ +++ E K+ EE++ + E+
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Query: 742 NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAEL 801
+ E++KK ++ EE+I E + QE+ +K+ + +K ++ EQ ++ +
Sbjct: 676 KIREQEKKIREQ----EEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQE 730
Query: 802 QTQWEAKCEHLLASAKDEHLQQY 824
+ WE + + ++E +Q++
Sbjct: 731 EKMWE---QEVRLRQQEEKMQEH 750
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 86.3 bits (212), Expect = 2e-16
Identities = 135/712 (18%), Positives = 279/712 (39%), Gaps = 72/712 (10%)
Query: 536 KVEELQKHSAGNSML-------IPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRI 588
+++ L++ A ++ L I + T+E M+ ++ +++ L+++I R
Sbjct: 132 EIQALRQKQASHAQLGDAYDQEIRELRATLE--MVNHEKAQVQLDSDHLEEDIHRLKERF 189
Query: 589 EEQ---NDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEEL 645
EE+ D I ++ +E+++L+ + + +Q+ + + E+E A + ++
Sbjct: 190 EEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQI 249
Query: 646 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQ 705
A+ V T E++ QL ES + ++ + + + + ++L E +EQ +
Sbjct: 250 QASHITVERKDYLKTDISTALKEIRSQL-ESHSDQNMHQAE-EWFKCRYAKLTEAAEQNK 307
Query: 706 SKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR 765
+S K+ + ++ S EL +R KESLE+ LS+ +++ + S
Sbjct: 308 EAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLS---------- 357
Query: 766 KSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQ 825
SYQ+ + +L L+ T+ + E L+ ++ E L ++ +
Sbjct: 358 -SYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFA 416
Query: 826 EVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE--QHIKELEKNKSQMSGVEAAASDP 883
+ + + K + + L Q++ + I E K + + S +E A +
Sbjct: 417 GSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAI 476
Query: 884 SEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEE 943
+E++ M + + E E E + + +K T + ++E EKEE +E
Sbjct: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAK-KSPVK-ATAPEVKEEEGEKEEEEGQE 534
Query: 944 EEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ 1003
EEE+ +E + E+ S G + + E +E EEA + +
Sbjct: 535 EEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ--EEGETEAEAEGEEAEAKEEKKVEEKS 592
Query: 1004 DGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPE-----PLGPVSMDSEC 1058
+ K + A+A E + + P + P P E P+ ++ +
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 652
Query: 1059 EESLAASPMAAKPDNPSGKVCVREVA----PDGPLQESSTRLSLTSDPEEGDPLALGPES 1114
+ + SP+ K +P K V E A P P++E+ ++ + ++ + E+
Sbjct: 653 KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEA 712
Query: 1115 PGEPQ----------PPQLKKDD-------------VTSSTGPHKELSSTEAGSTVAGAA 1151
P E + P+ KK + +T S H E + E G +
Sbjct: 713 PKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ--- 769
Query: 1152 LRPSHHSQRSSLSGDEEDELFKGATLK-----ALRPKAQPEEEDEDEVSMKG 1198
+ + G EE+ KGA A+ + + +EE E E KG
Sbjct: 770 -QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKG 820
Score = 60.5 bits (145), Expect = 1e-08
Identities = 119/617 (19%), Positives = 235/617 (38%), Gaps = 77/617 (12%)
Query: 630 RVLHAEQEKAKVTEELAAATA-QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLT 688
+V + EQ+ ++ E+ A Q SH QL A+ ++ EL+ L +++ +
Sbjct: 118 KVHYLEQQNKEIEAEIQALRQKQASHAQLG-DAYDQEIRELRATL-------EMVNHEKA 169
Query: 689 KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKK 748
+VQ L+E + + +F+ E + R E + +L +++ + + K L+K + +
Sbjct: 170 QVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQD 229
Query: 749 KSAQERSQAEEEIDEIRKSYQ------EELDKLR----QLLKKTRVSTDQAAAEQLSLVQ 798
+ A RS EEE+ ++ Q E D L+ LK+ R + + + + +
Sbjct: 230 EVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAE 289
Query: 799 AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 858
+ ++ AK K+ +E+ R Q K ++L+ ++ L+
Sbjct: 290 EWFKCRY-AKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDI 348
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEK-------------VKKIMNQVFQSLRREFELE 905
E+H +L + + +E + VK ++ + R+ E E
Sbjct: 349 EERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGE 408
Query: 906 ES-------------YNGRTILGTIMNTIKMVTLQLLNQQEQEK------EESSSEEEEE 946
E+ Y R + TI + I+ ++ + Q K EE+ E+E+
Sbjct: 409 ETRFSTFAGSITGPLYTHRPPI-TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKS 467
Query: 947 KAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGH 1006
+ EE ++E + S + +A E+ E P E+V + P+ A ++
Sbjct: 468 EMEEALTAITEELAVSMKEEKKEAA--EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG 525
Query: 1007 RRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASP 1066
++ + E E +G+ + S + + G ++E EE A +
Sbjct: 526 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEE--AEAK 583
Query: 1067 MAAKPDNPSGKVCVRE--VAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGE------- 1117
K + S +V +E VA + + + P E + P+SP E
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 643
Query: 1118 PQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATL 1177
P+ P +K P +E + + P +S + +E A
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSKS-------PVEEKAKSPVPKSPVEE----AKS 692
Query: 1178 KALRPKAQPEEEDEDEV 1194
KA K + +EE+E EV
Sbjct: 693 KAEVGKGEQKEEEEKEV 709
Score = 40.4 bits (93), Expect = 0.010
Identities = 92/435 (21%), Positives = 180/435 (41%), Gaps = 89/435 (20%)
Query: 563 IMSNIQRIIQENERLK------QEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKR 616
I S IQ+ E +LK +EI+E++ ++E++ ++ E + + S M E++
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEET-KVEDEKSEMEEALTAITEELAVS--MKEEK 488
Query: 617 NNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES 676
+ + E +A E+E+ + ATA ++K +K+E E Q + E
Sbjct: 489 KEAAEEKEEEPEA-----EEEEVAAKKSPVKATAP----EVKEEEGEKEEEEGQEEEEEE 539
Query: 677 LKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR-------KQLELK---VTSLE 726
+ + + + + S +E EQ + + ++E + K++E K V + E
Sbjct: 540 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 599
Query: 727 EELTDLRVEKES-----LEKNLSERKKKSAQERSQAEEE---------IDE-----IRKS 767
E + D +VEK + K+ E K KS +S EE+ ++E + KS
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 659
Query: 768 YQEELDKL----RQLLKKTRVSTDQAAAEQL-SLVQAELQTQWEAKCEHLLASAKDEHLQ 822
EE K + +K + ++ E+ S + Q E + + + + K+E ++
Sbjct: 660 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719
Query: 823 QYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIK----------ELEKNKSQ 872
+ +E +D ++K + K A+ A++ +TK + H++ + EK K +
Sbjct: 720 KKEE--KPKDVPEKKKAESPVKEEAV-AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 776
Query: 873 MSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQ 932
G + + S+K K + ++ E E +E +
Sbjct: 777 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKE------------------------EV 812
Query: 933 EQEKEESSSEEEEEK 947
EQE +E S EEEK
Sbjct: 813 EQETKEKGSGREEEK 827
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 85.9 bits (211), Expect = 2e-16
Identities = 92/460 (20%), Positives = 207/460 (45%), Gaps = 52/460 (11%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRI 570
E ++ N +++ + V + + V+EL++ +L+P + E + +Q +
Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338
Query: 571 -------IQENE---RLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSL 620
++ENE RL Q+ EK R EE+ + E I+ + + + + ++ +
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 398
Query: 621 QTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKET 680
+ Q ++ ++EK + EE+ + Q +M +KE +++ +L E + E
Sbjct: 399 RR-----QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM--WEKEEKIR-ELEEKMHEQ 450
Query: 681 DLLRGQLTKVQA--KLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKES 738
+ +R Q K Q K+ E ++ EQ ++ E++ R+Q E K+ EE++ +
Sbjct: 451 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE-KIREQEEKMWRQEEKIHE 509
Query: 739 LEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQ 798
EK E K++ +E + EE+I E QEE+ + ++ + EQ ++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIRE-----QEEIWRQKEKIH-----------EQEEKIR 553
Query: 799 AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 858
+ + W E + +++ +Q ++V Q ++K+ + +EK + +I +
Sbjct: 554 KQEEKMWRQ--EEKMHDQEEKIREQEEKVWRQ----EEKIREQEEKIREQEEKIREQEEM 607
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIM 918
++ +++ + + +M E + EK+++ ++ + ++ E EE I
Sbjct: 608 TQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK---------IR 658
Query: 919 NTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQE 958
+M+ Q EQE++ EE+ ++ EE+ RR ++
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/484 (20%), Positives = 214/484 (44%), Gaps = 57/484 (11%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERL 577
E+ A+S VA + +EEL K S+ + ++T E + ++N +L
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE---------ELKEKNAKL 287
Query: 578 KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQE 637
+ EK +E + +I ++ +R +E++ L++ + + QA H +E
Sbjct: 288 Q----EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ---------QQLQAEADHLGKE 334
Query: 638 KAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSEL 697
V+ +L A QV +L +Q++E ++ Q + + + ++ Q K++ + ++
Sbjct: 335 LQSVSAKLQA---QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 698 QETSE----QAQSKFKSEKQNRKQLEL------KVTSLEEELTDLRVEKESLEKNLSERK 747
+E E Q + ++ E++ R+Q E+ K+ EE + + + LE+ + E++
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451
Query: 748 K-KSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWE 806
K + +E+ Q EE+I E K ++E RQ ++ EQ ++ + + W
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQ---------EEKIREQEEKIREQEEKMWR 502
Query: 807 AKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKEL 866
++E + + +++ + +Q+ + QE+ + Q +I ++ + +++
Sbjct: 503 ----------QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 867 EKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTL 926
K + +M E D EK+++ +V++ + E EE R I +M
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKI--REQEEKIREQEEMTQE 610
Query: 927 QLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQ 986
Q EQE++ EE+ ++ EE+ RR ++ + Q RE+ E E+
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 670
Query: 987 VVEE 990
+ E+
Sbjct: 671 MWEQ 674
Score = 65.5 bits (158), Expect = 3e-10
Identities = 77/363 (21%), Positives = 163/363 (44%), Gaps = 43/363 (11%)
Query: 609 SNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ---LKMTAHQKK 665
S+ +K NN T E T + H+ +++ K + + A + Q +++ QK
Sbjct: 144 SDTKKKKINNG--TNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQK- 200
Query: 666 ETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSL 725
TELQM L S L G+ + ++L + + + + + + +K+ + + L
Sbjct: 201 -TELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEEL 259
Query: 726 EEELTDLRVE---KESLEKNLSERKKKSAQERSQAEEEIDEIR---KSYQEELDKLRQLL 779
+E L +E ++ L E+ K ++ E E EI+ K + +L++ + LL
Sbjct: 260 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319
Query: 780 KKTRVSTD-QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL 838
+ ++ + ++L V A+LQ Q E E+ L + ++ QQ +++ Q + Q+
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQ--QQEEKMWRQEEKIQEWE 374
Query: 839 VQLQEKCLALQAQITALTKQNEQHIKELE---KNKSQMSGVEAAASDPSEKVKKIMNQVF 895
++QE+ ++ Q + +Q E+ ++ E + + +M E + EK+++ ++
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 434
Query: 896 QSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRP 955
+ + ELEE +++QE+ +E+ +EEEK E+ +R
Sbjct: 435 EKEEKIRELEEK---------------------MHEQEKIREQEEKRQEEEKIREQEKRQ 473
Query: 956 SQE 958
QE
Sbjct: 474 EQE 476
Score = 57.4 bits (137), Expect = 8e-08
Identities = 49/263 (18%), Positives = 125/263 (47%), Gaps = 12/263 (4%)
Query: 568 QRIIQENERLKQE--ILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
++I ++ +R +QE + + +I EQ +KI E E+ R E+ + + R + E
Sbjct: 464 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQE 523
Query: 626 NT--QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLL 683
Q + ++E + E++ ++ + KM ++K + + ++ E ++
Sbjct: 524 EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQ 583
Query: 684 RGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL 743
++ + + K+ E +E + + + +++ + E K+ EE++ + + E+ +
Sbjct: 584 EEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQT 803
E++KK ++ EE+I E + QE+ +K+ + +K ++ EQ ++ + +
Sbjct: 644 REQEKKIREQ----EEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEK 698
Query: 804 QWEAKCEHLLASAKDEHLQQYQE 826
WE + + ++E +Q++QE
Sbjct: 699 MWE---QEVRLRQQEEKMQEHQE 718
Score = 31.2 bits (69), Expect = 6.3
Identities = 31/159 (19%), Positives = 69/159 (43%), Gaps = 8/159 (5%)
Query: 511 EARQHNTE--IRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQ 568
E + H+ E IR KV + + + + E++++ + +T E M +
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE---EKIREQEEMTQEQEEKMGEQE 619
Query: 569 RIIQENERLKQEILEKSNRIEEQ-NDKISELIERNQRYVEQSNLMMEKRNNSLQTATE-- 625
+ E E QE EK R EE+ ++ ++ E+ ++ EQ +M E+ + +
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK 664
+ ++ E++ + E++ ++ + KM HQ+
Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 85.9 bits (211), Expect = 2e-16
Identities = 94/457 (20%), Positives = 206/457 (45%), Gaps = 30/457 (6%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
Q+ +RL++E + + EE+ ++ E E+ +R +Q E+R L+ E + +
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE----ERREQQLRREQEERREQQ 350
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESL-------KETDLLR 684
L EQE+ + ++L + Q ++ Q+ E Q++ + L +E L R
Sbjct: 351 LRREQEEERREQQLRREQEEERREQ-QLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q + + +L Q+ + + + +K +++ E ++ +EE D +E E++
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469
Query: 745 ERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQ 804
ER+K+ + + E ++ +E ++ + ++ R ++ ++L + E + Q
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 805 WEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE 860
+ E L ++E L++ +E +++ +Q+L + QE+ + L K+ E
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE------RRDQLLKREE 583
Query: 861 QHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNT 920
+ ++ K + + + + E++++ + Q L+RE E EE + +
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKRE-EPEEERRQQLLKSEEQEE 641
Query: 921 IKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESP 980
+ L+ QQE+ ++ EEEEE+ E+R +R +E+ + + RER +S
Sbjct: 642 RRQQQLR-REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS- 699
Query: 981 MVPSEQVVEEAVPLPPQALTTS----QDGHRRKGDSE 1013
+P Q E+ Q+ S Q+G RR+ + E
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Score = 77.0 bits (188), Expect = 1e-13
Identities = 95/431 (22%), Positives = 183/431 (42%), Gaps = 53/431 (12%)
Query: 568 QRIIQENERLKQEILEKSNRIEE----QNDKISELIERNQRYVEQSNLMMEKRNNSLQTA 623
QR + E E +Q ++ R +E + ++ + ER Q+ E+ + + E +
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 624 TENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLL 683
Q E+E+ + L A A L+ + Q++E ELQ + E + +
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 684 RGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL 743
R + Q + E Q E+ + + + E++ + + + K+ EE+L L E E +
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL--LGEEPEKRRRQE 985
Query: 744 SERKKKSAQERSQAEEEI----------DEIRKSY-------QEELDKLRQLLKKTRV-- 784
E+K + +E Q EE++ E + Y QEE LR+ +K R+
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045
Query: 785 ------STDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL 838
++ E+ L+ E +T+ + E K+E LQQ +E + + +++
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELER--QYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 839 VQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQ-- 896
+ + +C + L ++ EQ ++E E+ K + +E + E+V++ Q+ +
Sbjct: 1104 QERERQC----REEEELQQEEEQLLRE-EREKRRRQELERQYRE-EEEVQQEEEQLLREE 1157
Query: 897 -SLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQE----QEKEESSSEEEEEKAEER 951
RR ELE Y ++ QLL +++ QE+E EEEE + ++R
Sbjct: 1158 PEKRRRQELERQYREE-------EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 952 PRRPSQEQSAS 962
+R E S
Sbjct: 1211 KQRYRDEDQRS 1221
Score = 75.5 bits (184), Expect = 3e-13
Identities = 99/496 (19%), Positives = 202/496 (40%), Gaps = 62/496 (12%)
Query: 572 QENERLKQEIL-EKSNRIEEQNDKISELIERNQRYVEQSNLMME---KRNNSLQTATENT 627
QE ER +Q++ E+ EQ + + + R Q+ + L E +R L+ +
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 628 QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQL 687
+ + L EQ+ + EE + H Q + K+E E + + +ET+ +
Sbjct: 415 REQQLRREQQLRREQEE---ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 688 TKVQAKLSELQETSEQ---AQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
K Q K + +E E+ + + + E+Q R++ +L+ +EE + R++++ E+ L
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE--QEERREQRLKRQEEEERLQ 529
Query: 745 ERKKKSAQERSQAEEEIDEIRKSYQE---ELDKLRQLLKKTRVST-DQAAAEQLSLVQAE 800
+R + Q R + EE +++ K +E E ++ Q LK+ + DQ + Q
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE 860
L+ + E + E L + E L+Q + +++ ++ +E + Q+ +Q E
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEER--------REQRLKREEPEEERRQQLLKSEEQEE 641
Query: 861 QHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNT 920
+ ++L + + + + E++++ + + + RRE EL E + I +
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA-RERIKSR 700
Query: 921 IKMVTLQL-------------------------------------LNQQEQEKEESSSEE 943
I QL L QE+E+ +E
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760
Query: 944 EEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ 1003
EE++ + + ++E+S P RE+ E + E+ E LP + +
Sbjct: 761 EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR 820
Query: 1004 DGHRRKGDSEAEALSE 1019
RR+ + E + L E
Sbjct: 821 RRQRREREKELQFLEE 836
Score = 66.6 bits (161), Expect = 1e-10
Identities = 100/435 (22%), Positives = 191/435 (43%), Gaps = 56/435 (12%)
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENT 627
+++ Q+ E+L E EK R +E+ K E E Q E+ L+ E+R + E
Sbjct: 964 KKLQQKEEQLLGEEPEKRRR-QEREKKYREEEELQQ---EEEQLLREEREKRRRQEWERQ 1019
Query: 628 QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKET--DLLRG 685
+ +QE+ E+L + LQ + ++++E ELQ + + L E R
Sbjct: 1020 YRKKDELQQEE----EQLLREEREKRRLQERERQYREEE-ELQQEEEQLLGEERETRRRQ 1074
Query: 686 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSE 745
+L + K ELQ+ EQ + E + R++ E + EEE +L+ E+E L + E
Sbjct: 1075 ELERQYRKEEELQQEEEQL---LREEPEKRRRQERERQCREEE--ELQQEEEQLLREERE 1129
Query: 746 RKKKSAQERSQAEEEI--DEIRKSYQEELDKLR-QLLKKTRVSTDQAAAEQLSLVQAELQ 802
++++ ER EEE E + +EE +K R Q L++ ++ E+ L++ E
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE-- 1187
Query: 803 TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQ---EKCLALQAQITALTKQN 859
Q + + E ++E LQ+ + RD Q+ ++ Q EK A++ +
Sbjct: 1188 -QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 860 EQHIKELE----KNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILG 915
+ ++LE +++ ++ + E+ ++ + +Q R F EE
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ-------- 1298
Query: 916 TIMNTIKMVTLQLLNQQEQEKEESSSEEEE----EKAEERPRRPSQEQSASASSGQPQAP 971
L+ Q+E ++ + S+EE+ E+ EE+ RR ++ + +
Sbjct: 1299 ----------LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF-----REEEQ 1343
Query: 972 LNRERPESPMVPSEQ 986
L +ER E P+ E+
Sbjct: 1344 LLQEREEQPLRRQER 1358
Score = 66.2 bits (160), Expect = 2e-10
Identities = 97/448 (21%), Positives = 197/448 (43%), Gaps = 42/448 (9%)
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENT 627
+R +E E+L+QE + + E+ +K ER ++Y + L ++ Q E
Sbjct: 927 ERQYREEEQLQQE---EEQLLREEREKRRRQ-ERERQYRKDKKLQQKEE----QLLGEEP 978
Query: 628 QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQ------KKETELQMQLTESLKETD 681
+ R ++K + EEL Q+ + + Q +K+ ELQ + + L+E +
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE-E 1037
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ +L + + + E +E ++ + E++ R++ EL+ +EE +L+ E+E L +
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE--ELQQEEEQLLR 1095
Query: 742 NLSERKKKSAQERSQAEEE--IDEIRKSYQEELDK-LRQLLKKTRVSTDQAAAEQLSLVQ 798
E++++ +ER EEE E + +EE +K RQ L++ ++ E+ L++
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 799 AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 858
E + + + E ++E LQQ +E + + Q+K Q +E+ Q +
Sbjct: 1156 EEPEKRRRQELER--QYREEEELQQEEEQLLREE--QEKRRQERER------QYREEEEL 1205
Query: 859 NEQHIKELEKNKSQMSGV--------EAAASDPSEKVKKIMNQVFQSLR--REFELEESY 908
Q K+ +++ Q S + E A D K N+ F+ L + + +
Sbjct: 1206 QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQE-KEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
+ + +LG + + Q+++ EE E EE+K +R R SQE+ +
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE-E 1324
Query: 968 PQAPLNRERPESPMVPSEQVVEEAVPLP 995
+ R+ + EQ+++E P
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 65.5 bits (158), Expect = 3e-10
Identities = 102/475 (21%), Positives = 196/475 (41%), Gaps = 54/475 (11%)
Query: 572 QENERLKQEILEKSNRIEEQND-KISELIERNQRYVEQSN--LMMEKRNNSLQTATENTQ 628
QE +R +QE EK R E + + E R Q+ EQ + + +
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 629 ARVLHAEQEKAKVTEELAAATAQ---VSHLQLKMTAHQKKETELQMQLTESLKETDLLRG 685
AR EQ + ++ E Q + + Q++E E ++Q E ++ R
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR-RE 844
Query: 686 QLTKVQAKLSELQETSEQAQSK-----------FKSEKQNRKQLELKVTSLEEELTD--- 731
+ ++Q + LQE E+ +S+ + E++ R+ +L+E+L
Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904
Query: 732 -LRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA 790
L+ E+E L++ E++++ QER EEE + QEE QLL++ R +
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEE-----QLQQEE----EQLLREEREKRRRQE 955
Query: 791 AEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQA 850
E+ +LQ K E LL ++ +Q +E ++ +++L Q +E+ L +
Sbjct: 956 RERQYRKDKKLQQ----KEEQLLGEEPEKRRRQERE---KKYREEEELQQEEEQLLREER 1008
Query: 851 QITALTKQNEQHIK--ELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
+ + Q+ K EL++ + Q+ E+ K+ + + + R E EL++
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLR--------EEREKRRLQERERQYREEEELQQEE 1060
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQE----QEKEESSSEEEEEKAEERPRRPSQEQSASAS 964
+LG T + L+ ++E QE+E+ EE E++ + R +E+
Sbjct: 1061 E--QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 965 SGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSE 1019
+ RE+ + + EE V + L + RR+ + E + E
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Score = 65.5 bits (158), Expect = 3e-10
Identities = 88/462 (19%), Positives = 188/462 (40%), Gaps = 38/462 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E ++L ++ ++ R EEQ + E R ++++E+ + ++R+ + + Q R
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 632 ---LHAEQEKAKVTEELAAATAQ-----VSHLQLKMTAHQKKETELQMQLTESLKETDLL 683
LH ++ K EE Q +L+ ++K E + QL ++ L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 684 RGQLTKVQAKLSEL-QETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
+ + Q + E Q+ + KF+ E+Q R++ E + S +E R+E++ + +
Sbjct: 1535 QEEQ---QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Query: 743 LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQ 802
ERK +++ + +E ++R+ + + QLL++ ++ E Q
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Query: 803 TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQH 862
+ + + E L +D ++ +++ + + Q + + K ++ EQ
Sbjct: 1652 LRRQER-EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK-----------FREEEQQ 1699
Query: 863 IKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIK 922
++ E+ + + + E+ + Q+ Q +E +L R IL +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE-QLRRQERYRKILEEEQLRPE 1758
Query: 923 MVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMV 982
QL Q+ K + +E+ E++ R SQE S + + L +ER E +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLR--SQE---SDRKFREEEQLRQEREEQQLR 1813
Query: 983 PSE-----QVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSE 1019
P + + EE + L Q Q+ R+ E A E
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Score = 62.4 bits (150), Expect = 3e-09
Identities = 100/443 (22%), Positives = 189/443 (42%), Gaps = 57/443 (12%)
Query: 573 ENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVL 632
E ER +QE+ E+ E+ ++I I + Q +E + + S E Q R
Sbjct: 677 EEERREQELAEEEQ--EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG-QRRRQ 733
Query: 633 HAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-------LKETDLLRG 685
E+++ + EL + +H Q + Q+++ Q Q E L LR
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQ-QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 686 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQL-----ELKVTSLEEELT------DLRV 734
Q + Q + E Q+ ++ + + ++Q R+Q EL+ EE+L L+
Sbjct: 793 QRER-QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 735 EKESLEKNLSERKKKSAQERSQAEE-EIDEIRK----------SYQEELDKLRQLLKKTR 783
E++ L+++ ER++ Q R Q +++E RK + QE+L K +QLL++
Sbjct: 852 EEDGLQED-QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 784 VSTDQAAAEQLSLVQAELQ----TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLV 839
+ E+ + E Q Q + + E LL +++ +Q +E ++D +KL
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD---KKLQ 967
Query: 840 QLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
Q +E+ L + + ++ +++ +E E + + + E+ K+ + + R
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR------EEREKRRRQEWERQYR 1021
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQE- 958
++ EL++ + + LQ +Q +E+EE EEE+ EER R QE
Sbjct: 1022 KKDELQQEEE-----QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 959 ---QSASASSGQPQAPLNRERPE 978
Q + L RE PE
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPE 1099
Score = 61.2 bits (147), Expect = 6e-09
Identities = 82/416 (19%), Positives = 179/416 (43%), Gaps = 36/416 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
++ ERL+Q ++ R EE + E ER +R E+ L K + + + E Q R
Sbjct: 156 EKQERLEQR--DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE-QLRR 212
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQ 691
+ + K EE Q++E + ++ E KE R + T ++
Sbjct: 213 RELLELRRKGREE---------------KQQQRRERQDRVFQEEEEKEW---RKRETVLR 254
Query: 692 AKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSA 751
+ +LQE Q Q + + E++ ++LE + L E + +++ L + R+K+
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 752 QERSQAEEEIDEIRKSYQEELDKLRQLLKK---------TRVSTDQAAAEQLSLVQAELQ 802
+ R Q EE ++ + Q+E + +QL ++ R ++ +QL Q E +
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 803 TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQH 862
+ + + E L +++ L++ Q++ ++ +++ ++ +E+ L + Q+ + +
Sbjct: 373 REQQLRREQQL--RREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQ 429
Query: 863 IKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIK 922
+E + K + E E+ + + + ++ R E E + R
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 923 MVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPE 978
+ + +Q++ +E+ E+EE+ E+R +R +E+ Q L RE+ E
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQEE 544
Score = 58.2 bits (139), Expect = 5e-08
Identities = 75/369 (20%), Positives = 156/369 (42%), Gaps = 39/369 (10%)
Query: 600 ERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKM 659
E +QR E + +E+ + Q R L +E+++ E L Q +L
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR 175
Query: 660 TAHQKKETELQMQLTESLK-----ETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN 714
+ +E E + E L+ ET+ + + +L EL+ + + + + E+Q+
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 715 RKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDK 774
R E + + T LR E+E L++ +R+++ +E +E+L K
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE---------------EEQLRK 280
Query: 775 L-RQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDA 833
L RQ L++ R +Q + + Q K E ++E +Q + Q +
Sbjct: 281 LERQELRRERQEEEQQQQ------RLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIK---ELEKNKSQMSGVEAAASDPSEKVKKI 890
+Q+L + QE+ Q + ++ EQ ++ E E+ + Q+ + + + ++
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 891 MNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEE 950
+ + Q LRRE +L + + + + ++EQE+E + E+E+ E+
Sbjct: 395 LRRE-QQLRREQQLRREQQ--------LRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 951 RPRRPSQEQ 959
R +R +E+
Sbjct: 446 RLKREQEER 454
Score = 56.2 bits (134), Expect = 2e-07
Identities = 71/406 (17%), Positives = 177/406 (43%), Gaps = 52/406 (12%)
Query: 568 QRIIQENERL-----KQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
++ ++E ++L +++ L++ ++ Q +R++++ E+ L E+ L
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 623 ATENTQARV----LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESL 677
+ + R+ + ++++ K E+ Q QL+ +K +E E QL +
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE---QLLQER 1631
Query: 678 KETDLLRGQLT-KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT----DL 732
+E L R + K + +L+ + Q + +++ R++ +L E++L D
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 733 RVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAE 792
+ +E + ER++K QE Q + E+ + ++EE ++LRQ ++ ++ E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQ--ELERKFREE-EQLRQETEQEQLRRQ----E 1744
Query: 793 QLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQI 852
+ + E Q + E + + L +D ++ +++ +R+ Q ++ QE + +
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ---LRSQESDRKFREEE 1801
Query: 853 TALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRT 912
++ EQ ++ +++ E + E+ ++ Q R++ EE + +
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ------RLRQERDRQYRAEEQFATQ- 1854
Query: 913 ILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQE 958
+ +E++E EEE+++ +ER R+ +E
Sbjct: 1855 -----------------EKSRREEQELWQEEEQKRRQERERKLREE 1883
Score = 53.5 bits (127), Expect = 1e-06
Identities = 74/332 (22%), Positives = 135/332 (40%), Gaps = 42/332 (12%)
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKS 750
+ +L+E +E SE+ + + ++Q R + + +E + R E+E L+ ++
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204
Query: 751 AQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE 810
E E+ E+R+ +EE + R+ Q + Q E + +W K E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRR-------------ERQDRVFQEEEEKEWR-KRE 250
Query: 811 HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNK 870
+L K+E Q +E QR+ ++ +E+ L+ Q +Q E+ ++ + +
Sbjct: 251 TVL--RKEEEKLQEEEPQRQRELQEE-----EEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 871 SQM--SGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQL 928
Q+ E E+ ++ + Q RRE +L R QL
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR------------EQQL 351
Query: 929 LNQQEQEKEESS--SEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE---RPESPMVP 983
+QE+E+ E E+EEE+ E++ RR Q + + Q L RE R E +
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ--LRREQQLRREQQLRR 409
Query: 984 SEQVVEEAVPLPPQALTTSQDGHRRKGDSEAE 1015
+Q+ E Q L Q+ R + E E
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/426 (17%), Positives = 174/426 (40%), Gaps = 19/426 (4%)
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISELIE-RNQRYVEQSNLMMEKRNNSLQTATEN 626
+R +E E L+++ ++ R E+Q + E + V + + + R N E+
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 627 TQARV---------LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESL 677
+Q R L EQ++ +E + H + ++++ E + + +S
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEEL------TD 731
+E LLR + + + + ++ E+ Q + E+Q ++ E EEEL
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 732 LRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA 791
E++ L + ERK +++ + +E ++R+ + + Q L +R D+
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL--SRQERDRKFR 1433
Query: 792 EQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQ 851
E+ V+ + + + + E L + ++ +++ +R+ Q + K L + Q
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 852 ITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGR 911
+ + + +EL + + +E ++ ++ Q Q LRR+ ++ R
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 912 TILGTIMNTIKMV-TLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
++ Q L++QE++++ E++ + E+ + EQ GQ Q
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 971 PLNRER 976
R+R
Sbjct: 1614 RQERDR 1619
Score = 50.1 bits (118), Expect = 1e-05
Identities = 58/271 (21%), Positives = 121/271 (44%), Gaps = 20/271 (7%)
Query: 531 DHLMTKVEELQKHSAGNSMLI----PSMSVTMETSMIMSNIQRIIQENERLKQEILEKSN 586
+ L+ + EE Q H P + + + R +E E+L QE E+
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 587 RIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEE-L 645
R +E++ K E ++ +R + + E++ Q + + + EQ + + +E L
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQ----QLRRQELERKFREEEQLRQETEQEQL 1740
Query: 646 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQ 705
L+ + +++E +L+ Q E D + +++ + E Q S+++
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQ------ERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 706 SKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERS---QAEEEID 762
KF+ E+Q R++ E + ++ R E+E L+ L E++++ QER +AEE+
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ--LEEQEQRLRQERDRQYRAEEQFA 1852
Query: 763 EIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
KS +EE + ++ +K R ++ E+
Sbjct: 1853 TQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Score = 44.7 bits (104), Expect = 6e-04
Identities = 56/279 (20%), Positives = 127/279 (45%), Gaps = 33/279 (11%)
Query: 568 QRIIQENERLK-------QEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSL 620
++++QE E + ++ LE+ ++ Q + +R++++ E+ L+ E L
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 621 QTATENTQARV----LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES 676
+ + + R L ++ + K +E Q + + ++ETE Q QL
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE-QEQLRRQ 1743
Query: 677 LKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEE------ELT 730
+ +L + +++ + E Q ++ KF+ E+Q R++ E + +E E
Sbjct: 1744 ERYRKILEEE--QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 731 DLRVEKESLEKNLSER--KKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVST-D 787
LR E+E + +R K + +E+ Q EE+ +R+ ++ RQ + + +T +
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ------ERDRQYRAEEQFATQE 1855
Query: 788 QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQE 826
++ E+ L Q E Q + + + L ++EH+++ Q+
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKL----REEHIRRQQK 1890
Score = 43.5 bits (101), Expect = 0.001
Identities = 67/333 (20%), Positives = 140/333 (42%), Gaps = 19/333 (5%)
Query: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM--MEKRNNSLQTATEN 626
R +E+E+L QE E+ +E++ K E + +R + L +++ + +
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLK-----ETD 681
+ + L ++ K EE Q + Q + EL+ + E + E +
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
LR Q + + L E Q E+ + + + ++++RK E + E E LR +ES K
Sbjct: 1739 QLRRQ-ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR-SQESDRK 1796
Query: 742 NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTD-QAAAEQLSLVQAE 800
E + + +E Q + + + ++EE +L + ++ R D Q AE+ Q +
Sbjct: 1797 FREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE 860
+ + + + + E ++ +E +R QQK Q + +++Q + +
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRR---QQKEEQRHRQVGEIKSQ------EGK 1907
Query: 861 QHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
H + LE Q + V +S E +++ +Q
Sbjct: 1908 GHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940
Score = 32.0 bits (71), Expect = 3.7
Identities = 60/313 (19%), Positives = 117/313 (37%), Gaps = 66/313 (21%)
Query: 721 KVTSLEEELTDLRVEKESLEKNLSERKKKSAQER-----SQAEEEIDEIRKSYQEELDKL 775
+ T L+EE KESL L +R+++ Q R Q EEE + R+ ++E ++
Sbjct: 91 QATGLDEEKRARCDGKESL---LQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER- 146
Query: 776 RQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQ 835
L + E Q++ + + E +DE L + ++ +R+ +
Sbjct: 147 -------------------ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 836 QKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVF 895
+ QLQ C + + +E+ ++ E + + G E E+ ++
Sbjct: 188 AEEEQLQS-CKGHETE----EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV----- 237
Query: 896 QSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRP 955
F+ EE R K T+ +++ ++EE + E ++ EE+ R+
Sbjct: 238 ------FQEEEEKEWR----------KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 956 SQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAE 1015
+++ L RER E E+ + + Q RR+ E
Sbjct: 282 ERQE------------LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 1016 ALSEIKDGSLPPE 1028
E ++ L E
Sbjct: 330 QQEERREQQLRRE 342
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 85.9 bits (211), Expect = 2e-16
Identities = 119/546 (21%), Positives = 237/546 (43%), Gaps = 61/546 (11%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSN---- 566
E ++ TE + + K D+ + + +L+K +A + I + +E ++ S
Sbjct: 598 EFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATE 657
Query: 567 -IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+Q I Q ER ++E+ + NR + +L+E + +E+++ Q + +
Sbjct: 658 LLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEE---------LEEKHREAQVSAQ 708
Query: 626 NTQARVLHAEQ---EKAKVTE-ELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETD 681
+ + + EQ EK KV + ++ A L+ M H+++ E L+E +
Sbjct: 709 HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMIN 768
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLE- 740
+ ++ ++ ++ EL E ++ A + ++N K E ++ L ++ L + LE
Sbjct: 769 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 828
Query: 741 --KNLSERKKK-SAQERS------QAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA 791
+ L E+ +K S Q+ S + E + E+ ++E+ +L++ L + ++S + +
Sbjct: 829 QNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERES 888
Query: 792 E--QLSLVQAELQTQW-EAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLA- 847
+ L +A L++Q +AK E L E ++ Q + A RD Q+K L+ C
Sbjct: 889 QLTALQAARAALESQLRQAKTE--LEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI 946
Query: 848 --LQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR----RE 901
L+ Q+ LT+ N EL +S AS ++++ ++ ++V R RE
Sbjct: 947 TDLEEQLNQLTEDN----AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITERE 1002
Query: 902 FELEESYNGRTILGTIMNTI--KMVTLQLLNQQEQEKE------ESSSEEEEEKAEERPR 953
+L L T + +++ L+ LN + EKE S +E+ + E R R
Sbjct: 1003 MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVR 1062
Query: 954 RPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSE 1013
+ S R R + + S QVVE AV + Q + + +
Sbjct: 1063 ELQRMLDTEKQS--------RARADQRITESRQVVELAVKEHKAEILALQQALKEQ-KLK 1113
Query: 1014 AEALSE 1019
AE+LS+
Sbjct: 1114 AESLSD 1119
Score = 60.5 bits (145), Expect = 1e-08
Identities = 62/303 (20%), Positives = 131/303 (43%), Gaps = 16/303 (5%)
Query: 613 MEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQ 672
MEK+ +++Q + EQE ++ ++ A +S ++++ A + + + L+
Sbjct: 447 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQD 506
Query: 673 LTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL 732
L + E L+ L QA++ QE + Q +Q+RK E+K + ++ ++
Sbjct: 507 LATYITECSSLKRSLE--QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEM 564
Query: 733 RVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAE 792
R+ LE++L +++S E E+ E R + +E K + K + DQ E
Sbjct: 565 RLMMNQLEEDLVSARRRS----DLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 620
Query: 793 -----QLSLVQAELQTQWEAKCEHLLASAK-----DEHLQQYQEVCAQRDAYQQKLVQLQ 842
+L + AE Q + + E L + K E LQ ++ + + +KL +
Sbjct: 621 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 680
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREF 902
+ ++ ++ + E+H + + ++ EK+K + NQ+ + L +
Sbjct: 681 DSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 740
Query: 903 ELE 905
LE
Sbjct: 741 TLE 743
Score = 58.9 bits (141), Expect = 3e-08
Identities = 75/322 (23%), Positives = 138/322 (42%), Gaps = 21/322 (6%)
Query: 528 DKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET-SMIMSNIQRIIQENERLKQEILEKSN 586
D++ L ++V+ L++ M + S TME + ++ + + E L E+LEK
Sbjct: 982 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKER 1041
Query: 587 RIEEQNDKISELIERNQRYVEQSNLMMEKRNNSL----QTATENTQARVLHAEQEKAKVT 642
+ E + + + + V + M++ S Q TE+ Q L ++ KA++
Sbjct: 1042 QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 1101
Query: 643 ---EELAAATAQVSHLQLKMTAHQKKETELQM---QLTESLKETDLLRGQLTKVQAKLSE 696
+ L + L K+ +KK L+M L + L+ L+ +L + QAKL
Sbjct: 1102 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ- 1160
Query: 697 LQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQ 756
Q+ Q F+ + ++ L+ + L+ E +DL + E+++ S K K SQ
Sbjct: 1161 -QQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQ 1218
Query: 757 AEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWE---AKCEHLL 813
+ ID ++ + K + L +R D A Q+ L EL+ E A+C L
Sbjct: 1219 QTKLIDFLQAKMDQPAKKKKGLF--SRRKEDPALPTQVPLQYNELKLALEKEKARCAELE 1276
Query: 814 ASAKDE--HLQQYQEVCAQRDA 833
+ + L+ +E A R A
Sbjct: 1277 EALQKTRIELRSAREEAAHRKA 1298
Score = 58.5 bits (140), Expect = 4e-08
Identities = 72/342 (21%), Positives = 155/342 (45%), Gaps = 58/342 (16%)
Query: 658 KMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQ 717
K ++ +KK +L +S + + ++T++ ++SE++ Q + + K+ + R
Sbjct: 443 KTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQR-- 500
Query: 718 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIR-----------K 766
+ LE++L E SL+++L + + + +QE +A + + +IR +
Sbjct: 501 -----SLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ 555
Query: 767 SYQEELDKLRQLLKKTRVSTDQAAAEQLS-LVQAELQTQWEA---------KCEHLLASA 816
YQ +++++R L ++ D +A + S L ++EL+ A +C+H L A
Sbjct: 556 EYQAQVEEMR--LMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKA 613
Query: 817 KDE---HLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE--QHIKELEKNKS 871
KD+ + +Y ++ Q K+ +LQEK L+ + A T+ E Q+I++ ++
Sbjct: 614 KDQGKPEVGEYAKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAE 670
Query: 872 QMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNT----------- 920
+ D SE ++K L ELEE + + +
Sbjct: 671 RELEKLQNREDSSEGIRK-------KLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEE 723
Query: 921 -IKMVTLQLLNQ-QEQEKEESSSEEEEEKAEERPRRPSQEQS 960
IK++ Q+ ++E E+ + EE+A E+ + S++++
Sbjct: 724 KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKA 765
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 85.1 bits (209), Expect = 4e-16
Identities = 103/444 (23%), Positives = 192/444 (43%), Gaps = 52/444 (11%)
Query: 559 ETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNN 618
E + + + ++I+E E + I K ++ E+Q+ L+E ME N
Sbjct: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH-----LVE------------MEDTLN 687
Query: 619 SLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETE-LQMQLTESL 677
LQ A + +V E +AK E+ S QLK T + + + L+ +E
Sbjct: 688 KLQEA----EIKVKELEVLQAKCNEQTKVIDNFTS--QLKATEEKLLDLDALRKASSEGK 741
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKE 737
E LR QL + ++ L+ SK S + + ELK+T+L+E L+++ KE
Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 738 SLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLV 797
+LEK L K+K A +A EE +++S QE ++KL Q ++ + + + +L
Sbjct: 802 TLEKELQILKEKFA----EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 857
Query: 798 QAELQTQWEAKCEHLLASAKDEHLQQYQEV-------------------CAQRDA--YQQ 836
E + + + + E L AK++ E+ +RD Q
Sbjct: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 837 KLVQLQEKCLALQAQITALTKQNEQHIKE-LEKNKSQMSGVEAAASDPSEKVKKIMNQVF 895
KL + E LQ I +T + EQ +E +K++ + +E SD +K++ NQ
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC- 976
Query: 896 QSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRP 955
Q L+ +E S +T I+ ++ L ++ + +EE+S +E + +
Sbjct: 977 QELKARYERATS-ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1035
Query: 956 SQEQSASASSGQPQAPLNRERPES 979
++ + + Q + +E+ E+
Sbjct: 1036 AKAAQTAEDAMQIMEQMTKEKTET 1059
Score = 72.4 bits (176), Expect = 2e-12
Identities = 92/486 (18%), Positives = 217/486 (44%), Gaps = 67/486 (13%)
Query: 510 TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
+E + ++R + ++ HL ++E+ + S +S+ ++ + + N+
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRELQGRELKLTNLQENLSE 795
Query: 570 IIQENERLKQEILEKSNRIEEQNDK-------ISELIERNQRYVEQSNLM---MEKRNNS 619
+ Q E L++E+ + E +++ + E + + + EQ N++ +EK +
Sbjct: 796 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 855
Query: 620 LQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKE-TELQMQLTESLK 678
L + + E++ K E+L A++ +KM+ + T++ +L +
Sbjct: 856 LADMEAKFREKD-EREEQLIKAKEKLENDIAEI----MKMSGDNSSQLTKMNDELRLKER 910
Query: 679 ETDLLRGQLTKVQAKLSELQETSEQAQSKFK-SEKQNRKQLELKVTSLEEELTDLRVEKE 737
+ + L+ +LTK S LQ++ E K + S+++ K+ E + LE +L+DL + E
Sbjct: 911 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 970
Query: 738 SLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEEL----DKLR----------QLLKKTR 783
+ E K + + S+ + + +EI ++ Q+ L DKL+ Q L++ R
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 784 VSTDQAAAEQL-----------------SLVQAELQTQWEAKCEHLLASAKDEHLQQYQE 826
D+A A Q +L E Q AK ++ L + K+ +L+ +E
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 827 VCAQR----------DAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGV 876
+ + + +++++ L++ Q++AL ++N + +EL +++ +++
Sbjct: 1091 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1150
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
+ E+ + NQ+ + +RE + + + ++ +I +T LL +++ E
Sbjct: 1151 QKL----EEERSVLNNQLLEMKKRESKFIKDADEEK--ASLQKSIS-ITSALLTEKDAEL 1203
Query: 937 EESSSE 942
E+ +E
Sbjct: 1204 EKLRNE 1209
Score = 45.1 bits (105), Expect = 4e-04
Identities = 93/487 (19%), Positives = 192/487 (39%), Gaps = 64/487 (13%)
Query: 585 SNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV--LHAEQ--EKAK 640
++ + + + L E + RY + + +LQ A + Q + L AE+ E+A+
Sbjct: 323 ASSVSSRPSRTGLLTETSSRYARKIS-----GTTALQEALKEKQQHIEQLLAERDLERAE 377
Query: 641 VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQET 700
V + + L L H + EL+ ++ + + + ++ +L E +
Sbjct: 378 VAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
Query: 701 SEQAQSKFKSEKQNRKQLEL-------KVTSLEEELTDLRVEKESLEKNLSERKKKS--- 750
E Q + + E + LE+ ++ LE++L E L + L K
Sbjct: 438 VEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 497
Query: 751 -----AQERSQAEEEIDEIRKSYQEELDKL------RQLLKKTRVSTDQAAAEQLSLVQA 799
QE S +E+++ R +Q E+ L R+ + + A E+LS
Sbjct: 498 MSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENE 557
Query: 800 ELQTQ--------------WEAKCEHLLAS---AKDEHLQQYQEVCAQRDA-YQQKLVQL 841
L+++ W++K E +AS A +E + + A + + Q+
Sbjct: 558 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 617
Query: 842 QEKCLALQAQITALTKQNEQ----HIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQS 897
++ L Q +I L Q + H KE+E ++++ V + E ++ +++
Sbjct: 618 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED- 676
Query: 898 LRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQ--EQEKEESSSEEEEEKAEERPRRP 955
+ E+E++ N IK+ L++L + EQ K + + + EE+
Sbjct: 677 -QHLVEMEDTLNKLQ-----EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 730
Query: 956 SQEQSASASSGQPQAPLNRERPES--PMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSE 1013
+ AS S G+ + R++ E+ + ++ + A ++T G K +
Sbjct: 731 DALRKAS-SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 789
Query: 1014 AEALSEI 1020
E LSE+
Sbjct: 790 QENLSEV 796
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 85.1 bits (209), Expect = 4e-16
Identities = 103/444 (23%), Positives = 192/444 (43%), Gaps = 52/444 (11%)
Query: 559 ETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNN 618
E + + + ++I+E E + I K ++ E+Q+ L+E ME N
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH-----LVE------------MEDTLN 722
Query: 619 SLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETE-LQMQLTESL 677
LQ A + +V E +AK E+ S QLK T + + + L+ +E
Sbjct: 723 KLQEA----EIKVKELEVLQAKCNEQTKVIDNFTS--QLKATEEKLLDLDALRKASSEGK 776
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKE 737
E LR QL + ++ L+ SK S + + ELK+T+L+E L+++ KE
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 738 SLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLV 797
+LEK L K+K A +A EE +++S QE ++KL Q ++ + + + +L
Sbjct: 837 TLEKELQILKEKFA----EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 892
Query: 798 QAELQTQWEAKCEHLLASAKDEHLQQYQEV-------------------CAQRDA--YQQ 836
E + + + + E L AK++ E+ +RD Q
Sbjct: 893 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 952
Query: 837 KLVQLQEKCLALQAQITALTKQNEQHIKE-LEKNKSQMSGVEAAASDPSEKVKKIMNQVF 895
KL + E LQ I +T + EQ +E +K++ + +E SD +K++ NQ
Sbjct: 953 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC- 1011
Query: 896 QSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRP 955
Q L+ +E S +T I+ ++ L ++ + +EE+S +E + +
Sbjct: 1012 QELKARYERATS-ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1070
Query: 956 SQEQSASASSGQPQAPLNRERPES 979
++ + + Q + +E+ E+
Sbjct: 1071 AKAAQTAEDAMQIMEQMTKEKTET 1094
Score = 72.4 bits (176), Expect = 2e-12
Identities = 92/486 (18%), Positives = 217/486 (44%), Gaps = 67/486 (13%)
Query: 510 TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
+E + ++R + ++ HL ++E+ + S +S+ ++ + + N+
Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 570 IIQENERLKQEILEKSNRIEEQNDK-------ISELIERNQRYVEQSNLM---MEKRNNS 619
+ Q E L++E+ + E +++ + E + + + EQ N++ +EK +
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890
Query: 620 LQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKE-TELQMQLTESLK 678
L + + E++ K E+L A++ +KM+ + T++ +L +
Sbjct: 891 LADMEAKFREKD-EREEQLIKAKEKLENDIAEI----MKMSGDNSSQLTKMNDELRLKER 945
Query: 679 ETDLLRGQLTKVQAKLSELQETSEQAQSKFK-SEKQNRKQLELKVTSLEEELTDLRVEKE 737
+ + L+ +LTK S LQ++ E K + S+++ K+ E + LE +L+DL + E
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
Query: 738 SLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEEL----DKLR----------QLLKKTR 783
+ E K + + S+ + + +EI ++ Q+ L DKL+ Q L++ R
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 784 VSTDQAAAEQL-----------------SLVQAELQTQWEAKCEHLLASAKDEHLQQYQE 826
D+A A Q +L E Q AK ++ L + K+ +L+ +E
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 827 VCAQR----------DAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGV 876
+ + + +++++ L++ Q++AL ++N + +EL +++ +++
Sbjct: 1126 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1185
Query: 877 EAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEK 936
+ E+ + NQ+ + +RE + + + ++ +I +T LL +++ E
Sbjct: 1186 QKL----EEERSVLNNQLLEMKKRESKFIKDADEEK--ASLQKSIS-ITSALLTEKDAEL 1238
Query: 937 EESSSE 942
E+ +E
Sbjct: 1239 EKLRNE 1244
Score = 57.8 bits (138), Expect = 6e-08
Identities = 92/488 (18%), Positives = 205/488 (42%), Gaps = 52/488 (10%)
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+I++++ E + + E+ + ++ + E +++ + + ++V L +E + + L+T E
Sbjct: 363 HIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV----LELEAKMDQLRTMVE 418
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG 685
A++EK ++ +L +V LQ ++ + +L+ Q L
Sbjct: 419 A-------ADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQ 471
Query: 686 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKE-------- 737
L + K +LQ E + SEK +LE + +E+ +LR E
Sbjct: 472 SLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV 531
Query: 738 ----SLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
SL + +S ++K R+ + EI +++ + + ++ +K +T++ + E
Sbjct: 532 DMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKEN 591
Query: 794 LSL---------VQAELQTQWEAKCEHLLAS---AKDEHLQQYQEVCAQRDA-YQQKLVQ 840
SL +++ W++K E +AS A +E + + A + + Q
Sbjct: 592 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 841 LQEKCLALQAQITALTKQNEQ----HIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQ 896
+++ L Q +I L Q + H KE+E ++++ V + E ++ +++
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711
Query: 897 SLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQ--EQEKEESSSEEEEEKAEERPRR 954
+ E+E++ N IK+ L++L + EQ K + + + EE+
Sbjct: 712 --QHLVEMEDTLNKLQ-----EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 764
Query: 955 PSQEQSASASSGQPQAPLNRERPES--PMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDS 1012
+ AS S G+ + R++ E+ + ++ + A ++T G K +
Sbjct: 765 LDALRKAS-SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN 823
Query: 1013 EAEALSEI 1020
E LSE+
Sbjct: 824 LQENLSEV 831
Score = 51.2 bits (121), Expect = 6e-06
Identities = 84/397 (21%), Positives = 168/397 (42%), Gaps = 36/397 (9%)
Query: 585 SNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV--LHAEQ--EKAK 640
++ + + + L E + RY + + +LQ A + Q + L AE+ E+A+
Sbjct: 323 ASSVSSRPSRTGLLTETSSRYARKIS-----GTTALQEALKEKQQHIEQLLAERDLERAE 377
Query: 641 VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTE-------SLKETDLLRGQLTKVQAK 693
V + + L L H + EL+ ++ + + +E L QL + + K
Sbjct: 378 VAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
Query: 694 LSELQETSEQAQSKFKSEKQNRKQLE-LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQ 752
+ +LQ E+ +S K + + + +LE ++ LE+ L + + + L++ L + + +
Sbjct: 438 VEDLQFRVEE-ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVS 496
Query: 753 ERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHL 812
E+S+ E ++ Q E+ +LR+ L+ + + D LSL+Q E+ + E
Sbjct: 497 EKSRIMELEKDLALRVQ-EVAELRRRLESNKPAGD--VDMSLSLLQ-EISSLQEK----- 547
Query: 813 LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQ 872
L + +H +E+ + ++ + + Q++ AL L+K+NE +LE +
Sbjct: 548 LEVTRTDH---QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 604
Query: 873 MSGVEAAASDPSEKVKKIMNQVFQSLRREF------ELEESYNGRTILGTIMNTIKMVTL 926
S V A E Q + L+ F E E +T + + +
Sbjct: 605 NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE 664
Query: 927 QLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASA 963
L NQQ+ E+ + E E +A+ +E S A
Sbjct: 665 NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1925 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2098 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2207
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1918
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1919 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2148
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2269 EAEKMKQVAE 2278
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1355
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1356 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1408 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1527 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1646 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2566 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Query: 968 PQA 970
A
Sbjct: 2615 VTA 2617
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1307 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1416
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1654
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1770
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1771 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2181
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2182 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2235 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2581
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641
Query: 904 LEESYNG 910
E S++G
Sbjct: 2642 PEHSFDG 2648
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1152
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1273 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1327
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1328 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1382
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1610
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1290
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1291 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1340
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1341 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1454 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1509 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1560
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1929 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2102 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2211
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1922
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1923 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2152
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2273 EAEKMKQVAE 2282
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1359
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1360 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1411
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1412 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1531 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1650 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2570 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Query: 968 PQA 970
A
Sbjct: 2619 VTA 2621
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1311 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1420
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1658
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1774
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1775 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2185
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2186 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2239 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2530 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2585
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2645
Query: 904 LEESYNG 910
E S++G
Sbjct: 2646 PEHSFDG 2652
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1156
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1157 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1216
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1277 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1331
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1332 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1386
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1614
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1294
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1295 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1344
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1345 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1458 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1513 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1564
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1925 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2098 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2207
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1918
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1919 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2148
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2269 EAEKMKQVAE 2278
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1355
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1356 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1408 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1527 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1646 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2566 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Query: 968 PQA 970
A
Sbjct: 2615 VTA 2617
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1307 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1416
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1654
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1770
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1771 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2181
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2182 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2235 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2581
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2641
Query: 904 LEESYNG 910
E S++G
Sbjct: 2642 PEHSFDG 2648
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1152
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1273 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1327
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1328 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1382
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1610
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1290
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1291 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1340
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1341 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1454 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1509 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1560
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1893 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2066 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2175
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1886
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1887 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2116
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2237 EAEKMKQVAE 2246
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1323
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1324 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1375
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1376 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1495 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1614 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2534 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Query: 968 PQA 970
A
Sbjct: 2583 VTA 2585
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1275 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1326
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1384
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1622
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1738
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1739 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2149
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2150 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2203 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2494 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2549
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2609
Query: 904 LEESYNG 910
E S++G
Sbjct: 2610 PEHSFDG 2616
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1061 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1120
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1121 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1180
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1241 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1295
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1296 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1350
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1578
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1258
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1259 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1308
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1309 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1422 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1477 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1528
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 2062 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2235 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2344
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 2055
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 2056 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2285
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2406 EAEKMKQVAE 2415
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1492
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1493 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1544
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1545 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1664 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1783 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2703 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Query: 968 PQA 970
A
Sbjct: 2752 VTA 2754
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1444 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1495
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1553
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1791
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1907
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1908 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2318
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2319 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2372 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2663 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2718
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2778
Query: 904 LEESYNG 910
E S++G
Sbjct: 2779 PEHSFDG 2785
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1230 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1289
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1410 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1464
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1465 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1519
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1747
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1427
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1428 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1477
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1478 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1591 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1646 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1697
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1903 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2076 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2185
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1896
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1897 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2008
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2126
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2187 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2247 EAEKMKQVAE 2256
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1333
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1334 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1385
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1386 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1505 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1624 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2544 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Query: 968 PQA 970
A
Sbjct: 2593 VTA 2595
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1285 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1336
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1394
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1632
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1748
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1749 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2159
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2160 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2213 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2384 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2504 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2559
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2619
Query: 904 LEESYNG 910
E S++G
Sbjct: 2620 PEHSFDG 2626
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1071 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1130
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1251 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1305
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1306 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1360
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1588
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1268
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1269 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1318
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1319 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1432 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1487 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1538
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1911 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2084 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2193
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1904
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1905 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2016
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2134
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2195 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2254
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2255 EAEKMKQVAE 2264
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1341
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1342 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1393
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1394 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1513 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1632 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2552 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Query: 968 PQA 970
A
Sbjct: 2601 VTA 2603
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1293 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1344
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1402
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1640
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1756
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1757 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2167
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2168 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2221 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2392 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2512 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2567
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2568 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2627
Query: 904 LEESYNG 910
E S++G
Sbjct: 2628 PEHSFDG 2634
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1079 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1138
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1139 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1198
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1259 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1313
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1314 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1368
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1369 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1596
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1276
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1277 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1326
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1327 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1440 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1495 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1546
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 85.1 bits (209), Expect = 4e-16
Identities = 106/474 (22%), Positives = 199/474 (41%), Gaps = 46/474 (9%)
Query: 531 DHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEE 590
+ ++ +K +AG + L +E I SN + ++ E+ + E + E
Sbjct: 1952 EEILALKASFEKAAAGKAEL------ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005
Query: 591 QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELA---- 646
+ + E ER Q+ + +R +L+ E +A+V A + + + +E A
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 647 -AATAQVSHLQLKMTAH----QKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETS 701
A A LQ + AH Q+KE ELQ L + D LRG+ + E +E
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 702 EQAQSKFKSEKQNRKQLE--LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEE 759
QA+ + Q+R+Q+E ++ EE R + ++ + L + ++ A R+QAE+
Sbjct: 2125 VQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181
Query: 760 EIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE 819
+++ E++K ++ ++T Q A + L LQ + ++LL DE
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLRLQLEETDHQKNLL----DE 2234
Query: 820 HLQQYQ----EVCAQRDAYQQKLVQLQ---EKCLALQAQITA-------LTKQNEQHIKE 865
LQ+ + E QR +++L ++ E+ L+A+I A K N Q +
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294
Query: 866 LEKNKSQMSGVEAA-ASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMV 924
E K + EAA S +++ ++ + L ++ L E + T
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354
Query: 925 TLQLLNQQE---QEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
+LL QQ+ QE+ E++E+ A++ Q + Q Q ++ E
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408
Score = 78.6 bits (192), Expect = 3e-14
Identities = 114/550 (20%), Positives = 223/550 (40%), Gaps = 56/550 (10%)
Query: 512 ARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNS-----MLIPSMSVTMETSMIMSN 566
A Q E+ ++KV +M+ L+ ++ S S L E + +
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
++ + +E +R +Q E + R + +++ L E+ E + L E + EN
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 627 TQARVLHAEQ--EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR 684
+ R L ++ ++ ++ E+ A A + ++ E E Q L E D LR
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-----DTLR 1945
Query: 685 GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLS 744
Q +V+ ++ L+ + E+A + + +LEL++ + D KE E +
Sbjct: 1946 -QRRQVEEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 745 ---------ERKKKSAQERSQ----AEEEIDEIRKSYQEELDKLR---QLLKKTRVSTDQ 788
ER+++ A+ER Q AEEE RK+ EE+++L+ + ++ R +Q
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2057
Query: 789 AAAEQLSLVQ--AELQTQWEAKCEHLLASAKDEH----LQQYQEVCAQRDAYQQKLVQLQ 842
+A QL L Q A+ + Q E K K++ LQQ Q V Q + +
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Query: 843 EKCLALQAQITALTKQNEQHIKELEKNK---SQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
E+ + Q Q+ + ++E E+ K + + A A +EK++K Q ++ R
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAAR 2175
Query: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959
R + + + M K Q L Q+ Q ++E ++ + + + + E+
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 960 SASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQ-------ALTTSQDGHRRKGDS 1012
+ +A R + E + +EE L + + +D +R
Sbjct: 2236 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295
Query: 1013 EAEALSEIKD 1022
EAE + ++ +
Sbjct: 2296 EAEKMKQVAE 2305
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/476 (21%), Positives = 197/476 (41%), Gaps = 62/476 (13%)
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ S + +IQE L+ E + + ISE + R + E+R Q
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---------EERLAEQQR 1382
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQK-KETELQMQLTESLKETD 681
A E + + A EK + E +H Q K A ++ KE + +MQ +E
Sbjct: 1383 AEERERLAEVEAALEKQRQLAE--------AHAQAKAQAEREAKELQQRMQEEVVRREEA 1434
Query: 682 LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
+ Q K + ELQ+ + ++++ +++ + + E +EEE+ +R++ E+ E+
Sbjct: 1435 AVDAQQQKRSIQ-EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 742 N----------LSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKK--TRVSTD-Q 788
L R +++ ++ QA+EE + +R+ Q+E + RQ + +RV + +
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 789 AAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLQQYQEVC--AQRDA---YQQKLVQL 841
AA E+ +QA EL+ Q E + E L A+ E +Q Q AQR A Q K
Sbjct: 1554 AAREKQRALQALEELRLQAE-EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 842 QEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
EK L+ + Q +E E+ Q + E A + ++++ + ++LR
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 902 FELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSA 961
+ EE + QQ+ + + +++EE E RR E+ A
Sbjct: 1673 LQAEE----------------------VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 962 SASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEAL 1017
+ L ++R + +++ E + +A T + R+ + E L
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/423 (21%), Positives = 184/423 (43%), Gaps = 36/423 (8%)
Query: 572 QENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV 631
+E +RLK E E + + + +++ + + + +E N +L ++ R
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 632 LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRGQLTKV 690
L E EK K E AA + + ++ +++ Q L E LKE + T++
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT-DLRVEKE-SLEKNL-SERK 747
+A+ LQ+ E AQ + + +++++Q+ ++ + L E++ LE + +ER
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 748 KKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA----------------A 791
K E S+A+ +E + ++++ +++ + L +T ++T + A
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 792 EQLSLVQAELQTQWEA-KCEHLLASAKDEHLQ--QYQEVCAQRDAYQQKLVQLQEKCLAL 848
E+L AEL+ + E + E L K E +Q Q +++ + A QQ + ++ L
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 849 QAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK-KIMNQVFQSLRREFELEES 907
+ I + EQ ++ Q+ + E+ + +++ + ++ RR+ E EE
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
K LQ L QQ +++EE +EE + E+ Q ++A A S +
Sbjct: 2593 VRR-----------KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Query: 968 PQA 970
A
Sbjct: 2642 VTA 2644
Score = 74.7 bits (182), Expect = 5e-13
Identities = 117/572 (20%), Positives = 241/572 (42%), Gaps = 53/572 (9%)
Query: 454 SGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQP-PHFQGSGDMASFLMTEA 512
SG+ Q Y ++ + Y + + +TSQ Y +S+ + +A E
Sbjct: 1334 SGSESVIQEYVDLRTH-YSELTTLTSQ-------YIKFISETLRRMEEEERLAEQQRAEE 1385
Query: 513 RQHNTEIRMAVSKVADKMD-HLMTKVE------ELQKHSAGNSMLIPSMSVTMETSMIMS 565
R+ E+ A+ K + H K + ELQ+ ++ ++
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM--QEEVVRREEAAVDAQQQKR 1443
Query: 566 NIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATE 625
+IQ +Q+ + + ++ R E ++ IE R V E++ + +
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVS-------HLQLKMTAHQKKETELQMQLTESLK 678
+AR AE +K + EE QV ++++ + K E E + +L+
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 679 ETDLLRGQLTKVQAKLSELQ-ETSEQAQSKFKSEKQNRK-QLELKVTSLEEELTDLR--- 733
+ LR Q + + +L + + E + Q Q ++ +++ + +L+ K S E+ L
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ L E ++ AQ++++AE +E + + K + L + R+ ++ A+Q
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL-RLRLQAEE-VAQQ 1681
Query: 794 LSLVQAELQTQ-WEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ--LQEKCLALQ- 849
SL QAE + Q EA+ E +E + +E+ Q Q++L + Q++ A Q
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 850 -AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESY 908
++ A T+Q EQ + LE+ +++ AAA+ ++++ + +V R E E+ +
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLAS 1797
Query: 909 NGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQP 968
R + +++ +++ E+ + E AEE R + + A
Sbjct: 1798 KARA----------EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Query: 969 QAPLNRERPESPMVPSEQV--VEEAVPLPPQA 998
+ R+R E+ V +E++ + EA L +A
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Score = 70.1 bits (170), Expect = 1e-11
Identities = 105/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 415 AHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQA 474
A A ++ +A Q + QA AAL Q + D+ + + Q
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE---------MEKHKKFAEQTLRQK 2208
Query: 475 SAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM 534
+ V +L +R L + H + D + + TE S+V +++ +
Sbjct: 2209 AQVEQELTTLR----LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 535 TKVEELQKHSAGNSMLIPSMSVTMETSMIM----SNIQRIIQENERLKQEILEKSNRIEE 590
++EEL K A + E ++ N QR +QE +++ E++ R+
Sbjct: 2262 VQMEELSKLKA---------RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 591 QNDKISELIERNQRYVEQSNLMMEK----RNNSLQTAT-------------ENTQARVLH 633
+ + L + + + Q + EK + ++Q AT E Q +
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 634 AEQEKAKVTEELAAATA---------QVSHLQLKMTAHQKKETELQMQLTESLKETDL-- 682
+++K ++ ++LA T + L++ A + K +M ++ E D
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKN 742
R Q ++ KL + +++ + ++ + R+Q + L E + +L EKE L++
Sbjct: 2433 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492
Query: 743 LSERKKKSAQ----ERSQAEEEIDEIRKSYQEELDKLRQ---LLKKTRVSTDQ------A 789
+ KS + ++ Q +E +++S+ E D L Q +++ + +Q A
Sbjct: 2493 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
A+QL Q Q Q E + + L+AS ++ +Q++ + ++K +LQ+ +
Sbjct: 2553 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQEELQQLEQQRR 2608
Query: 850 AQITALTKQNEQHIKEL----EKNKSQMSGVEAAASDPSEKVKKIMN--QVFQSLRREFE 903
Q L ++N++ ++L E++++ ++ E + K + N E E
Sbjct: 2609 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAE 2668
Query: 904 LEESYNG 910
E S++G
Sbjct: 2669 PEHSFDG 2675
Score = 67.4 bits (163), Expect = 8e-11
Identities = 113/529 (21%), Positives = 222/529 (41%), Gaps = 56/529 (10%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ Q E+ A + + + + EL+ A L T + +
Sbjct: 1120 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1179
Query: 568 QRIIQE-NERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLM---MEKRNNSLQTA 623
R QE ERL+Q E+ +E +++++L+ER Q + Q+++ +E+ L+
Sbjct: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
Query: 624 TENTQ--ARVLHAEQEKAKVTEELAAATAQVSHLQLK--------MTAHQKKETELQ--- 670
E+ L + + + + + A +Q QL+ + H +K E Q
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELT 730
Q ++K+ +L QL +A+L + +++ + + SE ++ ++L+ + ELT
Sbjct: 1300 KQYINAIKDYEL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR--THYSELT 1354
Query: 731 DLRVE-----KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK---KT 782
L + E+L + + E ++ + Q+R++ E + E+ + L+K RQL + +
Sbjct: 1355 TLTSQYIKFISETL-RRMEEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQA 1409
Query: 783 RVSTDQAAAEQLSLVQAELQTQWEAKCE-HLLASAKDEHLQQ--------YQEVCAQRDA 833
+ ++ A E +Q E+ + EA + + E LQQ Q Q +A
Sbjct: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
Query: 834 YQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQ 893
++ ++++E+ ++ Q+ A +Q EL+ +++ EA E+ +++ Q
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQ---QEQEKEESSSEEEEEKAE- 949
V +R+ + E R K LQ L + Q +E E + E E+A
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589
Query: 950 -----ERPRRPSQE--QSASASSGQPQAPLNRERPESPMVPSEQVVEEA 991
E +R ++ QS AS + A L R E V Q+ EEA
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLREEA 1637
Score = 64.7 bits (156), Expect = 5e-10
Identities = 99/473 (20%), Positives = 192/473 (40%), Gaps = 55/473 (11%)
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
IQ + + + +E L + + E+ ++ E +E QR+ +Q + ++ LQ T
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ--YINAIKDYELQLVTYK 1317
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQ 686
Q + + +K KV + + V + + H + T L Q + + ET
Sbjct: 1318 AQLEPVASPAKKPKVQ----SGSESVIQEYVDLRTHYSELTTLTSQYIKFISET------ 1367
Query: 687 LTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL---KVTSLEEELTDLRVEKESLEKNL 743
L ++E A+ + E++ ++E K L E + + E K L
Sbjct: 1368 -------LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 744 SERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK-KTRVSTDQAAAEQLSLVQAE-- 800
+R ++ R +A + + ++S QEEL +LRQ + + + QA A + S ++ E
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 801 ---LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTK 857
++ Q EA E A+ E Q + A+ + + + Q QE+ L+ Q+ ++
Sbjct: 1481 IRVVRLQLEA-TERQRGGAEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535
Query: 858 QNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR-------REFELEESYNG 910
+ Q EL S V+A A EK + + Q + LR R E
Sbjct: 1536 RKRQAEVEL------ASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERA 1587
Query: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
R + + + +L +++ E+++ E + E +E++ + Q +A
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ-------DGHRRKGDSEAEA 1016
RE E + + EA+ L QA +Q + ++K ++E EA
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 84.3 bits (207), Expect = 6e-16
Identities = 121/505 (23%), Positives = 225/505 (44%), Gaps = 56/505 (11%)
Query: 523 VSKVADKMDHLMTKVEELQ------KHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENER 576
+ K+ + L KVE L+ K S N + S + E + + I+ + + +ER
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL-SKDLMKEKAQLEKTIETLRENSER 551
Query: 577 LKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQ 636
+ +ILE+ N E N +S L +R+Q E +EK N L + + T +++ E
Sbjct: 552 -QIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 637 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSE 696
EK ++ +EL H + K ++ EL+ +L KE +LL+ ++T ++ +
Sbjct: 609 EKRQIKKEL-------EHYKEK----GERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 697 L----QETS--EQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKS 750
+ QE S E+ K K + K L ++ SLE+E + L E L +N+ E K +
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV-ESLKCA 716
Query: 751 AQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTD--QAAAEQLSLVQAELQTQWE-- 806
+ + +Q + E E+ +S +E+L K +LLK + T+ + + + L + LQ E
Sbjct: 717 SMKMAQLQLENKEL-ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 807 -AKCEHLLASAKDEHL--QQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHI 863
K + L + +D + Q Q+ + ++L QL+++ +L+ + + L K +Q
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
Query: 864 KE--------------LEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN 909
KE LE+N ++ +E S+++ + E E +E
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 910 GRTILGTIMNTIK--MVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
TI + T++ +V+ +L QQ E + E E+ + R EQS S
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDS--- 952
Query: 968 PQAPLNRERPESPMVPSEQVVEEAV 992
+ L + ES + S ++ EE +
Sbjct: 953 -RYKLLESKLESTLKKSLEIKEEKI 976
Score = 80.9 bits (198), Expect = 7e-15
Identities = 113/502 (22%), Positives = 217/502 (43%), Gaps = 76/502 (15%)
Query: 514 QHNTEIRMAVSKVADKMD-HLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQ 572
Q N + VS + + +V++++K N +L S+ ETS S + +I
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKE---NKILHESIK---ETS---SKLSKIEF 608
Query: 573 ENERLKQEI---LEKSNRIEEQNDKISELIERNQ----------------RYVEQSNLMM 613
E ++K+E+ EK R EE +++ L + N+ +EQ N +
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 614 EKRNNSLQTATE---NTQARVLHAEQEKAKVTEE----------LAAATAQVSHLQLKMT 660
E+ N L+ + N ++ E+E +++ EE L A+ +++ LQL+
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 661 AHQKKETELQMQLT---ESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQ 717
+ ++ +L+ L S K+T+ L + + LQ+T E + K + + +
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 718 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQ 777
LE++ +L++ L +L++ + LE+ L + K QE SQ E++ +K ++E +LRQ
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQ-LEKENKSLEQETSQLEKD----KKQLEKENKRLRQ 843
Query: 778 L--LKKTRVSTDQAAAEQLSLVQAELQTQ---WEAKCEHLLASAKDEHLQQYQEVCAQRD 832
+K T + + L L + ++ C L K+ +E+ +
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-----KELVKRAT 898
Query: 833 AYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEK---NKSQMSGVEAAASDPSEKV-- 887
+ LV L+E ++ + + + E+ ELEK NK ++ E + D K+
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
Query: 888 KKIMNQVFQSLR--------REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEES 939
K+ + + +SL E LEES N L + T+K L +Q++E+
Sbjct: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
Query: 940 SS---EEEEEKAEERPRRPSQE 958
SS E+ K E + ++E
Sbjct: 1019 SSPPISGEDNKWERESQETTRE 1040
Score = 66.6 bits (161), Expect = 1e-10
Identities = 94/419 (22%), Positives = 180/419 (42%), Gaps = 51/419 (12%)
Query: 498 FQGSGDMASFLMTEARQHNTEIRMAVSKVAD-KMDH--LMTKVEELQKHSAGNSMLIP-S 553
+QG L N +I+ S++ D +M++ L +EEL+ S L +
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 554 MSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMM 613
S+ ETS + + +++ +EN+RL+Q+ K +EE N KI L + N+ ++ +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 614 EKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQL 673
E + R+ E+E ++ + + T K L+ L
Sbjct: 878 E------------SCVRLKELEKENKELVK--------------RATIDIKTLVTLREDL 911
Query: 674 TESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR-KQLELKVTSLEEELTDL 732
+T + L K+ +L ++ E+ +S +R K LE K+ S ++ ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 733 RVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAE 792
+ EK + L R ++S Q +E+ ++K+Y E K RQ D+
Sbjct: 972 KEEKIAA---LEARLEESTNYNQQLRQELKTVKKNY--EALKQRQ---------DEERMV 1017
Query: 793 QLSLVQAELQTQWEAKCEHL---LASAKDEHLQQYQE---VCAQRDAYQQKLVQLQEKCL 846
Q S + +WE + + L KD ++ + + A++ A + +L QL+ +
Sbjct: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
Query: 847 ALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELE 905
LQAQI AL +Q ++ ++Q + ++ S + + +MNQ Q L ++ LE
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Score = 65.5 bits (158), Expect = 3e-10
Identities = 104/462 (22%), Positives = 193/462 (41%), Gaps = 63/462 (13%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSN----------- 566
E + V K+ ++ ++ +++ + A L V +ET ++ +
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDK 376
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
+ + +EN +LK ++ + + KI EL+E N +L+ A +
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM---------------TLEMAQKQ 421
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRG 685
+ LH E +++ T+++S K H+ E LT S L + ++
Sbjct: 422 SMDESLHLGWELEQISR-----TSELSEAPQKSLGHEVNE------LTSSRLLKLEMENQ 470
Query: 686 QLTKVQAKLSELQETSEQAQSKF-KSEKQNRKQLELKVTSLEEELT-------------- 730
LTK +L ++ E SK K EK+N++ L KV LE E+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQR-LSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 731 DLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA 790
DL EK LEK + ++ S ++ E+E + + ++ L + Q+ + RV +
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKE 588
Query: 791 AEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQA 850
+ L E ++ +K E K E L+ Y+E + + + +L L+++ LQ
Sbjct: 589 NKILHESIKETSSKL-SKIEFEKRQIKKE-LEHYKEKGERAEELENELHHLEKENELLQK 646
Query: 851 QITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN- 909
+IT L K + I+ LE+ S++ + K + Q+ +SL +E + N
Sbjct: 647 KITNL-KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKENSQLDEENL 704
Query: 910 --GRTILGTIMNTIKMVTLQLLNQQ-EQEKEESSSEEEEEKA 948
R + ++KM LQL N++ E EKE+ E KA
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Score = 55.1 bits (131), Expect = 4e-07
Identities = 78/402 (19%), Positives = 165/402 (41%), Gaps = 53/402 (13%)
Query: 571 IQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR 630
++E+ Q++ ++ +++ + + + +++ + QS+ + +N + ++ T
Sbjct: 983 LEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPISGEDNKWERESQETTRE 1040
Query: 631 VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKV 690
+L + +V A A+ L+ ++ + + LQ Q+ ++T L+ Q T +
Sbjct: 1041 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1100
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL----EKNLSER 746
Q + ++LQ + S+ S QL ++ +SLE E + E+E L + + +
Sbjct: 1101 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1160
Query: 747 KKKSAQERSQAEEEIDEIRK-------------SYQEELDKLRQLLKKTRVSTDQAAAEQ 793
+K QA E I K +++ D+ QLLK+ D
Sbjct: 1161 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED------ 1214
Query: 794 LSLVQAELQTQWEAKCEHLLASAKDEH--LQQYQEVCAQRDAYQQKLVQLQEKCLALQAQ 851
L+ + + E +L K+ +Y+++C + D QL ++ LQ
Sbjct: 1215 -------LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT- 1266
Query: 852 ITALTKQNEQHIKELEKN-KSQMSGVEAAASDPSEKVK-------KIMNQVFQSLRREFE 903
+ +++K L N K + + +EA S E+ + K+ NQ + +
Sbjct: 1267 -------DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319
Query: 904 LEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEE 945
LEE R +L I T+ + LL Q + K+ E+ +
Sbjct: 1320 LEE--ENRHLLDQI-QTLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Score = 54.3 bits (129), Expect = 7e-07
Identities = 70/337 (20%), Positives = 151/337 (44%), Gaps = 32/337 (9%)
Query: 630 RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTK 689
R++ E ++ EL+ + L ++ Q M+ TES + + +L
Sbjct: 199 RLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV---ELAD 255
Query: 690 VQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL-------RVEKESLE-- 740
+AK+ L++ E+ + KQ +Q+E+++ L++E +L R+ ++ L+
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 741 KNLSERKKKSAQERSQAEEEIDEIR--KSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQ 798
+ + R K E S+ +E + +I K+ EEL + Q+L +T+ + +QL +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE----DQLEGTR 371
Query: 799 AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 858
A E + E+L AK ++ +RD ++K+ +L E+ + L+ KQ
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEM------ERDMDRKKIEELMEENMTLE----MAQKQ 421
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTI--LGT 916
+ L Q+S + P + + +N++ S + E+E +T+ L T
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 917 IMNTIKMVTLQLLNQQEQEKEESSSEE--EEEKAEER 951
+++++ ++L +++ + S E E E +E+
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
Score = 41.2 bits (95), Expect = 0.006
Identities = 55/273 (20%), Positives = 116/273 (42%), Gaps = 43/273 (15%)
Query: 510 TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
T N ++ + S + ++ + ++ + E+L+ S +S++ + + S +
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLK--SLYDSLIKDHEKLELLHERQASEYES 1176
Query: 570 IIQENERLK----------QEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS 619
+I ++ LK +++ ++ N++ +Q ++ +L VEQ +++E +N+
Sbjct: 1177 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL--EKMLKVEQEKMLLENKNHE 1234
Query: 620 LQTATENTQA----RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKK--ETELQMQ- 672
A R+ H + K TE L Q H LK + K +T L+ +
Sbjct: 1235 TVAAEYKKLCGENDRLNHTYSQLLKETEVL-----QTDHKNLKSLLNNSKLEQTRLEAEF 1289
Query: 673 --LTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSE-----KQNRKQLELKVTSL 725
L E ++ D+ +L LS+L+ E+ + QNR LE + S
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 726 E----------EELTDLRVEKESLEKNLSERKK 748
+ ++L +LR +KE LE+ + ++ K
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 84.3 bits (207), Expect = 6e-16
Identities = 127/576 (22%), Positives = 244/576 (42%), Gaps = 69/576 (11%)
Query: 493 SQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLM---TKVEELQKHSAGNS- 548
S+PP G + L TE Q +T IR K + + T LQ + S
Sbjct: 459 SRPPQPNIDGKV---LETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSP 515
Query: 549 ---------MLIPSMSVTMETSMIMSNIQRIIQE-NERLKQEILEKSNRIEEQNDKISEL 598
PS S T T ++ Q + Q+ NE ++IL N ++E + +
Sbjct: 516 DSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILY--NYLKEGSTDNDDA 573
Query: 599 IERNQRYVEQSNLMMEK----RNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSH 654
+R + NL+ EK ++ + +A N QA ++ E + E+ + T +V+
Sbjct: 574 TKR------KVNLVFEKIQTLKSRAAGSAQGNNQA--CNSTSEVKDLLEQKSKLTIEVAE 625
Query: 655 LQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSE--- 711
LQ ++ K + ++ + + LR Q + + S LQ+ E+++ + +
Sbjct: 626 LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
Query: 712 ----KQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERK----------KKSAQERSQA 757
K R+Q + ++ L+++L+++ E +S +++ K K+ Q+ A
Sbjct: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
Query: 758 EEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAK 817
+EE +++ + + EL L+ LK+ S DQ + AELQ E+ E A+
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE---ATKN 802
Query: 818 DEHLQQYQEVCAQRDAYQQKLVQ-LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGV 876
E L Q A + V+ LQE+ LQ + +++ E+ + +L++ + G
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGR----SEELERRVAQLQRQIEDLKGD 858
Query: 877 EAAASDPSEKVKKIMNQVFQSL-RREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQE 935
EA A + +K + + Q+ ++L E +E+ + R L + + Q +Q+Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918
Query: 936 KEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLP 995
E+ +EE E+ E+ R ++ ++ G+ L +E + + EA
Sbjct: 919 SEK--LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD---------IVEASRTS 967
Query: 996 PQALTTSQDGHRRKGDSE-AEALSEIKDGSLPPELS 1030
L D ++ K E AE ++K+ +L E S
Sbjct: 968 TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Score = 84.3 bits (207), Expect = 6e-16
Identities = 107/479 (22%), Positives = 202/479 (42%), Gaps = 78/479 (16%)
Query: 511 EARQHNTEIRMAVSKVADKMDHL-MTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
E QH TEIR ++++ D L K E ++ A L+ + + + +
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 570 IIQENER--------LKQEIL---EKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNN 618
++++ ER LK+E+ ++ ++++EQ D + + + ++ ++ R+N
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 619 SLQTATENTQARVLHAEQEKAKV---TEELAAATAQVSHL--QLKMTAHQKKET------ 667
+ + T+ RV ++E K+ +EEL AQ+ LK + KET
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 668 ---ELQMQLTESLKETD-------LLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQ 717
+L+ L + KE L +L Q LS+ + +Q K K E + ++Q
Sbjct: 872 EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 718 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQ 777
L +E E L E L+K +++ + S + + ++DE ++ + EL ++++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 778 LLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQK 837
LK+ + AE+ L ++Q + +E L+ YQ
Sbjct: 992 QLKEKTLE-----AEKSRLTAMKMQDEMR---------LMEEELRDYQ------------ 1025
Query: 838 LVQLQEKCLALQAQITALTKQN--EQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVF 895
+AQ ALTK+ EQ +K+LE S ++ D S VK++ ++V
Sbjct: 1026 -----------RAQDEALTKRQLLEQTLKDLEYELEAKSHLK---DDRSRLVKQMEDKVS 1071
Query: 896 QSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRR 954
Q E ELEE N +L ++ + QL N+ QE+ E ++ + ER +
Sbjct: 1072 Q---LEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Score = 62.8 bits (151), Expect = 2e-09
Identities = 81/391 (20%), Positives = 163/391 (41%), Gaps = 54/391 (13%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQ 568
+ E + ++R +++ ++ HL +E+LQK A ++ S + T+E
Sbjct: 922 LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA--DIVEASRTSTLELQ------N 973
Query: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQ 628
++ + E+ ++E+ E +++E+ + + + ++ LM E+ + + E
Sbjct: 974 QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALT 1033
Query: 629 ARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLT 688
R L EQ + EL A + + + K ++L+M+L E +DLL
Sbjct: 1034 KRQL-LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL----- 1087
Query: 689 KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKK 748
++S +E EQ +++ E+ R+ LE SLE + DL+ LE + K+
Sbjct: 1088 --SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
Query: 749 KSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAK 808
+ E+++ +S EE D+ L R+ E K
Sbjct: 1146 GLVVQMEARIAELEDRLES--EERDRANLQLSNRRL---------------------ERK 1182
Query: 809 CEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEK 868
+ L+ DEHL + Q+D QL + A++ Q+ ++ E+ I LE
Sbjct: 1183 VKELVMQVDDEHL----SLTDQKD-------QLSLRLKAMKRQV----EEAEEEIDRLES 1227
Query: 869 NKSQMSGVEAAASDPSEKVKKIMNQVFQSLR 899
+K ++ D +E ++ +N + + LR
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 84.0 bits (206), Expect = 8e-16
Identities = 103/503 (20%), Positives = 232/503 (46%), Gaps = 44/503 (8%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQ 568
++E + E+ SK+ +++D++ T +EE +K + + ++E+ + + Q
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK----KGIKFAKDAASLESQL--QDTQ 1321
Query: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQ 628
++QE R K + + ++EE+ + + E Q E++ +EK+ +LQ+ +T+
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQE----QQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 629 ARV-------LHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETD 681
+V E+ K K+ ++ A + ++ L +K + LQ +L + + D
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 682 LLR---GQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKES 738
R L K Q K +L + +++ +E+++R + E + E+E L + + +
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARY-AEERDRAEAEAR----EKETKALSLAR-A 1491
Query: 739 LEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAE---QLS 795
LE+ L E K++ ++ Q +++++ S ++++ K L+K++ + +Q E QL
Sbjct: 1492 LEEAL-EAKEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 796 LVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITAL 855
++ ELQ +AK L + + Q +++ + + ++K L ++ L+A++
Sbjct: 1550 ELEDELQATEDAKLR-LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 856 TKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR--------EFELEES 907
KQ + +K + + +EA E K ++V + LR+ + ELEE+
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQI----EAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 908 YNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
R + + L + Q +EE +S E + E+ R ++ +++SG+
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 968 PQAPLNRERPESPMVPSEQVVEE 990
+ R E+ + E+ +EE
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEE 1747
Score = 82.4 bits (202), Expect = 2e-15
Identities = 103/481 (21%), Positives = 190/481 (39%), Gaps = 66/481 (13%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSM-IMSNIQR 569
EAR+ T+ +A ++ + EE ++ N L M M + + N+
Sbjct: 1477 EAREKETK----ALSLARALEEALEAKEEFERQ---NKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 570 IIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENT-- 627
+ + L+Q++ E ++EE D++ + R M + LQT E
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE 1589
Query: 628 -------QARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKET 680
Q R L AE E + LA A+ + + LK +L+ Q+ + K
Sbjct: 1590 KKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK---------DLEAQIEAANKAR 1640
Query: 681 DLLRGQLTKVQAKLSELQETSEQAQS-------KFKSEKQNRKQLELKVTSLEEELTDLR 733
D + QL K+QA++ + Q E+A++ + K ++ K LE ++ L+EEL
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 734 VEKESLEK----------NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 783
+ E+ N + K E+ + E I ++ + +EE + L + R
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 784 VSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQE 843
+T Q+ + AEL + A A D QQ + Q + KL +L+
Sbjct: 1761 KTT-----LQVDTLNAELAAERSA------AQKSDNARQQLER---QNKELKAKLQELEG 1806
Query: 844 KCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE 903
A++++ A E I +LE+ Q + AAA+ + +K + ++F + E
Sbjct: 1807 ---AVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERR 1863
Query: 904 LEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASA 963
+ Y + M QL Q E+ +EE++ + +R + E +
Sbjct: 1864 HADQYKEQ------MEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 964 S 964
S
Sbjct: 1918 S 1918
Score = 79.3 bits (194), Expect = 2e-14
Identities = 108/554 (19%), Positives = 236/554 (42%), Gaps = 72/554 (12%)
Query: 499 QGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEE-------LQKHSAG----N 547
Q ++ L E + H +I+ + A ++ L ++E+ L+K+ G N
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 548 SMLIPSMSVTMETSM--------IMSNIQRI---IQENERLKQEILEKSNRIEEQNDKIS 596
L + V + + + +Q + + E +RL+ E+ EK+++++ + D +S
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Query: 597 ELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQ 656
L+E E+ + K SL++ ++TQ + ++K ++ + + + LQ
Sbjct: 1294 TLLEE----AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 657 LKMTAHQ-------KKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFK 709
+ + K+ LQ QL ++ K+ D G + ++ +L + +E + +
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 710 SEKQNRKQLELKVTSLEEELTDLRVE---KESLEKNLSERKKKSAQERSQAEEEIDEIRK 766
+ +LE L++EL DL V+ + + NL +++KK Q AEE+ I
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ--LLAEEK--SISA 1465
Query: 767 SYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQA-ELQTQWEAKCEHLLASAKDEHLQQYQ 825
Y EE D+ + R +A + +L +A E + ++E + + L A +D
Sbjct: 1466 RYAEERDRAEA---EAREKETKALSLARALEEALEAKEEFERQNKQLRADMED------- 1515
Query: 826 EVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSE 885
+ + +D + + +L++ AL+ Q+ + Q E+ EL+ A D
Sbjct: 1516 -LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ-----------ATEDAKL 1563
Query: 886 KVKKIMNQVFQSLRREFELEESYNG--RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEE 943
+++ M + R+ + + N + +L IK V +L + E E+++ +
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLL------IKQVR-ELEAELEDERKQRALAV 1616
Query: 944 EEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQ 1003
+K E + + Q +A+ + + + ++ M ++ +EEA + S+
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 1004 DGHRRKGDSEAEAL 1017
+ ++ EAE L
Sbjct: 1677 ESEKKLKSLEAEIL 1690
Score = 78.2 bits (191), Expect = 4e-14
Identities = 101/418 (24%), Positives = 192/418 (45%), Gaps = 68/418 (16%)
Query: 559 ETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIE-RNQRYVEQSNLMMEKRN 617
E ++ + I+E + ++ I E S+++ E+ +K L + RN++ V S+L E+R
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL--EERL 1043
Query: 618 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLT--- 674
+ + + + E + +++A AQ+ L+L++ KKE ELQ L
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA---KKEEELQGALARGD 1100
Query: 675 -ESLKETDLLRGQLTKVQAKLSELQETSEQAQ-SKFKSEKQNR---KQLELKVTSLEE-- 727
E+L + + L+ + ++QA+++ELQE E + S+ K+EKQ R ++LE T LE+
Sbjct: 1101 DETLHKNNALK-VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 728 ---------------ELTDLRVEKESLEKNLSERKKKSAQERSQAEEEID---EIRKSYQ 769
E+ +L+ E KN + + Q + A EE+ E K ++
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219
Query: 770 EELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQ-QYQEVC 828
L+K +Q L+ + ++ A ++ ++Q Q +A+ EH K + L Q QE+
Sbjct: 1220 ANLEKNKQGLE----TDNKELACEVKVLQ-----QVKAESEH-----KRKKLDAQVQELH 1265
Query: 829 AQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVK 888
A+ + V+L EK LQ ++ ++ E+ K+ K + +E+ D E ++
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 889 KIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEE 946
+ Q R +LEE N L +Q++E+EE+ E++
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNS------------------LQEQQEEEEEARKNLEKQ 1365
Score = 73.2 bits (178), Expect = 1e-12
Identities = 92/398 (23%), Positives = 169/398 (42%), Gaps = 39/398 (9%)
Query: 581 ILEKSNRIEEQNDKISEL--IERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEK 638
+L+ + + EE K EL ++ Q VE ME+++ L +N A L AE E
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL-LEEKNILAEQLQAETEL 902
Query: 639 AKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQ 698
EE+ A A +L+ H +L+ ++ E + +L+ + K+QA + +L+
Sbjct: 903 FAEAEEMRARLAAKKQ-ELEEILH-----DLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 699 ETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLR------------------------V 734
E ++ + + + + E K+ +EEE+ L
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 735 EKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQL 794
E+E KNL++ + K S EE + + K+ QE R+L +T DQ A Q
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 795 SLVQAELQ-TQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQIT 853
+ + +LQ + E + + LA DE L + + R+ Q ++ +LQE + +A
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE-LQAQIAELQEDFESEKASRN 1135
Query: 854 ALTKQNEQHIKELEKNKSQMSG-VEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRT 912
KQ +ELE K+++ ++ A+ + K+ Q L++ E EE+ N
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR--EQEVAELKKALE-EETKNHEA 1192
Query: 913 ILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEE 950
+ + +L Q EQ K ++ E+ ++ E
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Score = 62.8 bits (151), Expect = 2e-09
Identities = 74/316 (23%), Positives = 144/316 (45%), Gaps = 32/316 (10%)
Query: 664 KKETELQMQLTESLKETDL---LRGQLTKVQAKLSELQET----SEQAQSK---FKSEKQ 713
++E ELQ + E LK + + G+L +++ K +L E +EQ Q++ F ++
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 714 NRKQLELKVTSLEEELTDL--RVEKESLEKNLSERKKKSAQERSQ-AEEEIDEIRKSYQE 770
R +L K LEE L DL RVE+E + + +KK Q Q EE++DE +E
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE-----EE 963
Query: 771 ELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQ 830
+ QL K T + + E++ L++ + + K ++ + + A+
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK------KLMEDRIAECSSQLAE 1017
Query: 831 RDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKI 890
+ + L +++ K + + + K+ E+ +ELEK K ++ G +D +++ ++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG---ETTDLQDQIAEL 1074
Query: 891 MNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKA-- 948
Q+ + + + EE G G K L+++ + + + E + E EKA
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 949 ---EERPRRPSQEQSA 961
E++ R S+E A
Sbjct: 1135 NKAEKQKRDLSEELEA 1150
Score = 48.1 bits (113), Expect = 5e-05
Identities = 55/274 (20%), Positives = 106/274 (38%), Gaps = 40/274 (14%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMS-----VTMETSMI 563
+ EAR EI + K+ L ++ +LQ+ A + + E +
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 564 MSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIER-----------NQRYVEQSNLM 612
S ++ E RL+ I + +EE+ + L +R N + +
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 613 MEKRNNSLQTATENTQARVLHAEQE---KAKVTEELAAATAQVSHL--QLKMTAHQ---- 663
+ N Q +N + + E E K+K ++A A++ L QL+ A +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 664 --------KKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR 715
KK E+ MQ+ + + D + Q+ K A++ +L+ E+A+ + +R
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 716 KQLELKVTSLEEELTDLRVEKESLEKNLSERKKK 749
++ L+ EL D E L + +S K +
Sbjct: 1901 RK-------LQRELDDATEANEGLSREVSTLKNR 1927
Score = 38.1 bits (87), Expect = 0.052
Identities = 46/256 (17%), Positives = 110/256 (42%), Gaps = 31/256 (12%)
Query: 506 SFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMS 565
S L+ E R+ I ++ ++ ++ + +K + L ++ +
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 566 NI-QRIIQENERLKQEILEKSNRI-----------EEQNDKISELIERNQRYVEQSNLMM 613
N Q++ ++N+ LK ++ E + E + ++ E +E+ + +N ++
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 614 EKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKET------ 667
+ L+ + HA+Q K E++ A A++ L+ ++ +++ T
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYK----EQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 668 -ELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLE 726
+LQ +L ++ + + L +++ ++ +L S F S + R+QL L+ SL
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGGPIS------FSSSRSGRRQLHLEGASL- 1953
Query: 727 EELTDLRVEKESLEKN 742
EL+D E ++ + N
Sbjct: 1954 -ELSDDDTESKTSDVN 1968
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 83.2 bits (204), Expect = 1e-15
Identities = 98/423 (23%), Positives = 193/423 (45%), Gaps = 63/423 (14%)
Query: 520 RMAVSKVAD---KMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENER 576
++AV++V K + M K+ E++ S+L +++++N+Q I ER
Sbjct: 773 KLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG----QNLLLTNLQTIQGILER 828
Query: 577 LKQEILEK-SNRIEEQNDKISELIERNQRYVEQS-----NLMMEKRNNSLQTATE----- 625
+ E ++ S++IE+ +IS L ++ + VEQ NL ++ + Q TE
Sbjct: 829 SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL 888
Query: 626 NTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRG 685
NT+ + +A++E A + + L+ QV+ + T + + ++ D L
Sbjct: 889 NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK---------EDVDDLVS 939
Query: 686 QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSE 745
QL + + ++++L+E + K+ N +Q + VTSLEE L + E + KN+
Sbjct: 940 QLRQTEEQVNDLKE-------RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEV 992
Query: 746 RKKKSAQERSQAEEEIDEIRKSYQEELDKLRQL----------LKKTRVSTDQAAAEQLS 795
R K+SA+ ++Q E+++ E+ K QE D R+ LKKT S E L
Sbjct: 993 RLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ 1052
Query: 796 LVQAELQTQWEAK--C----------------EHLLASAKDEHLQQYQEVCAQRDAYQQK 837
L + +A+ C E +L +A E LQ +E ++ + +Q
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQH 1112
Query: 838 LVQLQEKCLALQAQITALTKQNEQHIK-ELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQ 896
L + +K + + A ++ E+ +K E+ K + +E ++++K+ ++V
Sbjct: 1113 LEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 897 SLR 899
S++
Sbjct: 1173 SVK 1175
Score = 74.7 bits (182), Expect = 5e-13
Identities = 139/700 (19%), Positives = 287/700 (41%), Gaps = 74/700 (10%)
Query: 538 EELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENE---RLKQEILEKSNRIEEQNDK 594
E++++ A N L V+ + ++++ E E + Q++ E+ R++ + +
Sbjct: 1330 EDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
Query: 595 ISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVT------------ 642
+ + NQ ++ + K +T ++ A+++ +++ +T
Sbjct: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
Query: 643 -EELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKET-DLLRGQLTKVQAKLSELQET 700
EEL A +V + + + E + +Q + LKET + + +++++ LQ+T
Sbjct: 1445 YEELKAQQDKVMETSAQSSGDHQ-EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT 1503
Query: 701 SEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEE 760
+ +++ ++ ++ QL+ +++ L ++L D ++E L + ++E+++K+ + A+ +
Sbjct: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 761 IDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEH 820
I + +++L K + LK+ + DQ ++L + L++Q+E + L + EH
Sbjct: 1564 IAHL-AGVKDQLTKENEELKQRNGALDQ-QKDELDVRITALKSQYEGRISRLERELR-EH 1620
Query: 821 LQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALT--KQNEQHIKELEKNKSQMSGVEA 878
+++ E QRD Q+ ++ E+ Q QIT T E+ I +
Sbjct: 1621 QERHLE---QRDEPQEPSNKVPEQ----QRQITLKTTPASGERGIASTSDPPTANIKPTP 1673
Query: 879 AASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEE 938
S PS+ M + R S T+ N T ++ + E +E
Sbjct: 1674 VVSTPSKVTAAAMAGNKSTPR------ASIRPMVTPATVTNPTTTPTATVMPTTQVESQE 1727
Query: 939 SSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQA 998
+ + E E P S S ++S Q +++ P++ +Q + + P
Sbjct: 1728 AM--QSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQ-----PILTVQQQTQATAFVQP-- 1778
Query: 999 LTTSQDGHRRKGDSEAEALSEIKD--GSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDS 1056
+Q H + + E S I + S P E S V G ++ P L + +
Sbjct: 1779 ---TQQSHPQIEPANQELSSNIVEVVQSSPVERPS-TSTAVFGTVSATPSSSLPKRTREE 1834
Query: 1057 ECEESLAASPMAAKP--DNPSGKVCVREVAPDGPLQESSTRLSLTSDPEEGDPLALGPES 1114
E + ++ AS + + P K ++ V P G +E S + E +S
Sbjct: 1835 EEDSTIEASDQVSDDTVEMPLPKK-LKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDS 1893
Query: 1115 PGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKG 1174
GE VT G + + +E S L P Q+++ S +D KG
Sbjct: 1894 IGE---------GVTQ--GDYTPMEDSEETSQSLQIDLGPLQSDQQTTTS--SQDGQGKG 1940
Query: 1175 ATLKALRPKAQPEEEDEDEVSMKGRPPPTPLFGDDDDDDD 1214
+ + + EEED+DE + DDDD+DD
Sbjct: 1941 DDVIVI--DSDDEEEDDDENDGEHEDYEEDEEDDDDDEDD 1978
Score = 72.4 bits (176), Expect = 2e-12
Identities = 84/352 (23%), Positives = 151/352 (42%), Gaps = 34/352 (9%)
Query: 565 SNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTAT 624
S I + +E+ K E ++ IE++ E + R + L +EK NN L+ T
Sbjct: 34 SEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALT 93
Query: 625 EN------TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLK 678
E Q R + + + + EEL A + +++ + TE +L E LK
Sbjct: 94 EKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK 153
Query: 679 ETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLE-------EELTD 731
E++ +G+L Q KL ELQ + + + K +Q ++ L + T L +EL
Sbjct: 154 ESNTTKGEL---QLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 732 LRVEK--ESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQA 789
L EK E LE + KK +E S+ EE+++ ++ S + + LL K + + +Q
Sbjct: 211 LGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ- 267
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
QA ++ ++ L A K +L Y+ +A +L + E+ L
Sbjct: 268 --------QASMEEKFH---NELNAHIKLSNL--YKSAADDSEAKSNELTRAVEELHKLL 314
Query: 850 AQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRRE 901
+ K + H+ E+E++K QM EK + N + + +R+
Sbjct: 315 KEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
Score = 67.4 bits (163), Expect = 8e-11
Identities = 105/523 (20%), Positives = 215/523 (41%), Gaps = 61/523 (11%)
Query: 508 LMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNI 567
L+ E R+ + +R+ + K+ +++ L K +EL+ N + + T E + +
Sbjct: 68 LVNETRECQS-LRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE--LEAEK 124
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISEL------IERNQRYVEQSNLMMEKRNNSLQ 621
+ +I+ NERL QE+ + ++ N+K+ E ++ ++ S++ ++ R L+
Sbjct: 125 RDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLE 184
Query: 622 TATENTQARVLHAEQEKAKVTEELAAATAQVSH--LQLKMTAHQKKE--TELQMQLTESL 677
E ++ E T+EL A + + L+LK KKE + L+ Q+
Sbjct: 185 QEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKF--------------KSEKQNRKQLELKVT 723
+ L+ + + KL E +E + KF KS + + ++T
Sbjct: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
Query: 724 SLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTR 783
EEL L E K + + + Q + Q E+E+ E ++EL+ LL T+
Sbjct: 305 RAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATK 364
Query: 784 VSTDQAAAEQLSLVQ----------------AELQTQW-EAKCEHLLASAKDEHLQQY-Q 825
+ E+L+ + EL + E + + LL +++ + +Y
Sbjct: 365 RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD 424
Query: 826 EVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKEL-------EKNKSQMSGVEA 878
E+ + +A L + +E+ Q + +L+ + EQ +KE+ +K Q S +E
Sbjct: 425 EIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLER 484
Query: 879 AASDPSEKVKKIMNQVFQSLRREFELEESYNGRTI------LGTIMNTIKMVTLQLLNQQ 932
+VK + Q+ L ELEE+ I I ++ ++++ L++ +
Sbjct: 485 DNRRMEIQVKDLSQQIRVLL---MELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
Query: 933 EQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
E+ + ++ E +E+ + SS + L E
Sbjct: 542 NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLE 584
Score = 64.7 bits (156), Expect = 5e-10
Identities = 93/472 (19%), Positives = 196/472 (41%), Gaps = 48/472 (10%)
Query: 509 MTEARQHNTEIRMAVSKVADKMDHLMTKV---------EELQKHSAGNSMLIPSMSVTME 559
+ ++RQH ++ ++ + D L+++ L S ++ PS S T+
Sbjct: 593 LRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVS 652
Query: 560 TSMIMSNIQ--RIIQENERLKQ--EILEKSNRIEEQNDKI-SELIERNQRYVEQSNLMME 614
T + I+ I+ LKQ EI E + + +N+KI +E +E+ Q V
Sbjct: 653 TPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712
Query: 615 KRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLT 674
K + L A++ + + E + ++T + K+TA +K+ ++ +T
Sbjct: 713 KISTQLDFASKRYEMLQDNVEGYRREITS--------LHERNQKLTATTQKQEQIINTMT 764
Query: 675 ESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRV 734
+ L+ + +L + + L++ E + Q R+ L + LT+L+
Sbjct: 765 QDLRGAN---EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
Query: 735 EKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQL 794
+ LE++ +E K++ + + + E EI ++K + E+++ L + V
Sbjct: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR--- 878
Query: 795 SLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITA 854
Q + +T + LL +A+ E +Q L ++ + + +Q T
Sbjct: 879 ---QLDTETNLHLNTKELLKNAQKEIA-----------TLKQHLSNMEVQVASQSSQRTG 924
Query: 855 LTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN-GRTI 913
K + ++++ SQ+ E +D E++K + V Q LEES N + +
Sbjct: 925 --KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
Query: 914 LGTIMNTIKM---VTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSAS 962
+ I++ + + Q E++ E E++E + ++R S EQ S
Sbjct: 983 TEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLS 1034
Score = 62.4 bits (150), Expect = 3e-09
Identities = 135/697 (19%), Positives = 278/697 (39%), Gaps = 78/697 (11%)
Query: 523 VSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEIL 582
VSK+A HL E QK A + +L S M+ + + + E L+++
Sbjct: 1103 VSKMASVRQHLE---ETTQK--AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNR 1157
Query: 583 EKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS--------LQTATENTQARVLHA 634
++IE+ +DK+ ++ + +L E ++ ++ E + R A
Sbjct: 1158 LLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVA 1217
Query: 635 EQEKAKVTEELAAATAQVSHLQLKMTAHQKK---ETELQMQLTESLKETDLLRGQLTKVQ 691
+ E + + + ++ LQ + A ++K + Q E +K+T+ + V
Sbjct: 1218 QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN----VVM 1273
Query: 692 AKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEE---ELTD----LRVEKESLEKNLS 744
L+E E+ + + + ++LEL + L+E EL++ L+ EK+ LE+++
Sbjct: 1274 ETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333
Query: 745 ERKKKSAQERSQAEE-EIDEIRK-------------SYQEELDKLRQLLKKTRVSTD--- 787
K ++ SQ ++ + +E RK EE+ +L+ + ++ S
Sbjct: 1334 RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQ 1393
Query: 788 ---QAAAEQLSLVQAELQT-QWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQE 843
Q+ E L+ V+ E +T Q + + + K + + Q +++ + ++L Q+
Sbjct: 1394 NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD 1453
Query: 844 KCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFE 903
K + AQ + ++ ++E+++ K ++ E + +V+ + + +
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 904 L-EESYNGRTILGTIMNTIKMVTLQ--LLNQQEQEKEESSSE---EEEEKAEERPRRPSQ 957
L E++ ++ L + ++ T Q L QQ EKEE + + + K Q
Sbjct: 1514 LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQ 1573
Query: 958 EQSASASSGQPQAPLNRERPESP--MVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAE 1015
+ Q L++++ E + + E + + L Q+ H + D E
Sbjct: 1574 LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
Query: 1016 ALSEIKDGSLPPELSCIPSHRVLG------PPT-SIPPEPLGPVSMDSECEESLAASPMA 1068
+++ + L P+ G PPT +I P P+ VS S+ + A+ MA
Sbjct: 1634 PSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPV--VSTPSK----VTAAAMA 1687
Query: 1069 AKPDNPSGKV--CVREVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKD 1126
P + V P + + T+ E + A+ E P E P
Sbjct: 1688 GNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQE--AMQSEGPVEHVPVFGSTS 1745
Query: 1127 DVTSSTGPHKELSSTEAGSTV-----AGAALRPSHHS 1158
ST P+ + S ++ TV A A ++P+ S
Sbjct: 1746 GSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQS 1782
Score = 57.8 bits (138), Expect = 6e-08
Identities = 98/483 (20%), Positives = 198/483 (40%), Gaps = 40/483 (8%)
Query: 499 QGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTM 558
Q D A+ + + N + + V ++ ++ L+ ++EE + + + S ++
Sbjct: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
Query: 559 ETSMIMS------NIQRIIQENERLKQEILEKSN-RIEEQNDKISELIERNQRYVEQSNL 611
+ +I NI+ + Q+N+RL + E R E+ + S I Q +E +
Sbjct: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALT 588
Query: 612 MMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATA-QVSHLQLKMTAHQKKETELQ 670
+E+ S Q + + V + + +++ A S L A K
Sbjct: 589 ELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS 648
Query: 671 MQLTESLKETDLLRGQLTKVQAKLSELQETSEQ-AQSKFKSEKQNRKQLELKVTSLEEEL 729
++ + + + +A L +LQE E + K ++EK +QLE L+E++
Sbjct: 649 QTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE----KLQEQV 704
Query: 730 TDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQA 789
TDLR + + L K+ E + + + Y+ E+ L + +K +T
Sbjct: 705 TDLRSQNTKISTQLDFASKR--------YEMLQDNVEGYRREITSLHERNQKLTATTQ-- 754
Query: 790 AAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQ 849
+Q ++ Q A + +A + E+L++ +E+ + +L Q +E LA Q
Sbjct: 755 --KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV---RLSQQRESLLAEQ 809
Query: 850 AQITAL-----TKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQ--SLRREF 902
L T Q E E + S +E + S KK+ N+V Q +L R
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869
Query: 903 ELEESYNGRTILGTIMNTIKMVTLQLLNQQEQE---KEESSSEEEEEKAEERPRRPSQEQ 959
++ + + + L T N + + T +LL ++E ++ S E + A + +R + Q
Sbjct: 870 DV-QLLDTKRQLDTETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
Query: 960 SAS 962
++
Sbjct: 928 PSN 930
Score = 36.2 bits (82), Expect = 0.20
Identities = 63/288 (21%), Positives = 100/288 (34%), Gaps = 49/288 (17%)
Query: 940 SSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQAL 999
SS +E E++P S+ Q+ P+AP + RP P+ P + PPQ L
Sbjct: 2047 SSFSQEVSREQQPSSASERQA-------PRAPQSPRRPPHPLPP-----RLTIHAPPQEL 2094
Query: 1000 -TTSQDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSEC 1058
Q + S L L P + + H ++P P V ++
Sbjct: 2095 GPPVQRIQMTRRQSVGRGL------QLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDG 2148
Query: 1059 EESLAASPMAA------------KPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPEEGD 1106
SP A P S + ++A G L T L L + E G
Sbjct: 2149 FAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGG 2208
Query: 1107 PLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGD 1166
P +P + P + T+S S +T G + + +GD
Sbjct: 2209 RSV--PTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGTL-----STTNETATGD 2261
Query: 1167 EEDELFKGATLKALRPKA------QPEEE-----DEDEVSMKGRPPPT 1203
+ DE+F A + + +A Q EEE DE ++ + PP+
Sbjct: 2262 DGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPS 2309
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 83.2 bits (204), Expect = 1e-15
Identities = 104/449 (23%), Positives = 192/449 (42%), Gaps = 89/449 (19%)
Query: 522 AVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMET-SMIMSNIQRIIQENERLKQE 580
+V+++ +++D+L ++L+K + M I ++ MET S N++++ + L+ +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA---LEDQ 1259
Query: 581 ILEKSNRIEEQNDKISELIERNQRYVEQS---NLMMEKRNNSLQTATENTQARVLHAEQE 637
+ E + EEQ I++L + R +S + +++++ + + QA E+
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 638 KAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSEL 697
K ++ EE+ A +A LQ S + DLLR Q + Q +EL
Sbjct: 1320 KRQLEEEIKAKSALAHALQ------------------SSRHDCDLLREQYEEEQEAKAEL 1361
Query: 698 QETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQA 757
Q +A S+ Q R + E EEL E KKK AQ A
Sbjct: 1362 QRAMSKANSEVA---QWRTKYETDAIQRTEEL--------------EEAKKKLAQRLQDA 1404
Query: 758 EEEIDEI----------RKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEA 807
EE ++ + ++ Q E++ L ++ R + AA ++ ++ +W+
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDL--MIDVERTNAACAALDKKQRNFDKILAEWKQ 1462
Query: 808 KCEHL---LASAKDEHLQQYQEVCAQRDAYQQKLVQLQ---EKCLALQAQITALTKQ--- 858
KCE L +++ E E+ ++AY++ L QL+ + LQ +I+ LT+Q
Sbjct: 1463 KCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1522
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIM 918
+ I ELEK K Q+ E+ K + + E EE
Sbjct: 1523 GGKRIHELEKIKKQV-----------EQEKSELQAALEEAEASLEHEEG----------- 1560
Query: 919 NTIKMVTLQL-LNQQEQEKEESSSEEEEE 946
K++ +QL LNQ + E + +E++EE
Sbjct: 1561 ---KILRIQLELNQVKSEVDRKIAEKDEE 1586
Score = 78.2 bits (191), Expect = 4e-14
Identities = 92/477 (19%), Positives = 201/477 (42%), Gaps = 56/477 (11%)
Query: 523 VSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEIL 582
+ K D ++ + KVE+ +KH+ N + ++T E + + I ++ +E + L++
Sbjct: 954 LKKDIDDLELTLAKVEK-EKHATENKV----KNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 583 EKSNRIEEQNDKISELIERNQRYVEQSN-------------LMMEKRNNSLQTATENTQA 629
+ + ++ + DK++ L + + +Q + + +E+ L+ + Q
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 630 RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQ-------KKETELQMQLTESLKETDL 682
+ E +K ++ E+L ++S LQ K+ Q KK ELQ ++ E +E +
Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128
Query: 683 LRGQLTKVQAK-------LSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVE 735
R K + + L E+ E E+A ++ + K+ E + + +L + ++
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 736 KESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAA--EQ 793
E+ L +KK A ++ E+ID +++ Q KL + + ++ D A+ E
Sbjct: 1189 HEATAATL---RKKHADSVAELGEQIDNLQRVKQ----KLEKEKSEMKMEIDDLASNMET 1241
Query: 794 LSLVQAELQTQWEAKCEHL--LASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQ 851
+S + L+ A + L + + ++E + ++ AQR Q + + +
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 852 ITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFEL-----EE 906
++ L++ + +++E+ K Q+ + K K + QS R + +L EE
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQL--------EEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 907 SYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASA 963
+ L M+ Q + E + + + E EE K + R E+ A
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Score = 70.1 bits (170), Expect = 1e-11
Identities = 82/424 (19%), Positives = 188/424 (44%), Gaps = 47/424 (11%)
Query: 513 RQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIM-----SNI 567
++ N ++ +S + +++ ++ EL+K + +E + I
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
Query: 568 QRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVE--QSNLMMEKRNNS------ 619
RI E ++K E+ +I E++++I ++ + R VE QS L E R+ +
Sbjct: 1563 LRIQLELNQVKSEV---DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619
Query: 620 --LQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESL 677
++ + ++ HA + A+ A + QL + + + +L+ QL
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSL-------EEELT 730
+ +LL+ ++ +++A L + + + + A+ + + + L + TSL E +++
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 731 DLRVEKESL---EKNLSERKKKSAQERSQAEEEI--DEIRKSYQEELDK-LRQLLKKTRV 784
++ E E + +N E+ KK+ + + EE+ ++ ++ E + K L Q +K +
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Query: 785 STDQAAAEQLSLVQAELQTQ-WEAKCEHLLASAKDE-------------HLQQYQEVCAQ 830
D+A EQL+L + Q Q EA+ L + E H ++ +E+ Q
Sbjct: 1800 RLDEA--EQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 831 RDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKI 890
+ ++ +++LQ+ LQA++ + +Q E+ ++ N S+ ++ + E+
Sbjct: 1858 TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Query: 891 MNQV 894
+QV
Sbjct: 1918 ESQV 1921
Score = 68.2 bits (165), Expect = 5e-11
Identities = 82/428 (19%), Positives = 187/428 (43%), Gaps = 38/428 (8%)
Query: 569 RIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQ 628
++I+ +L+ +I E + R E++ + +EL + +R +E ++K + L+ +
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAK-KRKLEDECSELKKDIDDLELTLAKVE 969
Query: 629 ARVLHAEQEKAK-VTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQL 687
+ HA + K K +TEE+A ++ K+T +K E Q + L+ + L
Sbjct: 970 -KEKHATENKVKNLTEEMAGLDETIA----KLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
Query: 688 TKVQAKL----SELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL 743
TK + KL +L+ + EQ + ++ +++LE + +E D+ +K+ L++ L
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 744 SERKKKSAQERSQAEEE------IDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSL- 796
+++ + + +S+ E+E + + K Q +++L + ++ R S +A ++ L
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 797 ------------------VQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKL 838
Q E+ + EA+ + + ++ LQ R + +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204
Query: 839 VQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSL 898
+L E+ LQ L K+ + E++ S M V A + + + + +Q+ +
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK 1264
Query: 899 RREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEE--EEKAEERPRRPS 956
+E E + N T + T + L++++ + S ++ ++ EE R+
Sbjct: 1265 TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 957 QEQSASAS 964
+E A ++
Sbjct: 1325 EEIKAKSA 1332
Score = 63.5 bits (153), Expect = 1e-09
Identities = 96/448 (21%), Positives = 195/448 (43%), Gaps = 50/448 (11%)
Query: 611 LMMEKRNNSLQTATENTQA--RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETE 668
L+ E R+ L TQA R A E K+ E + +++ M +
Sbjct: 776 LLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMK 835
Query: 669 LQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEE 728
L ++ LK + + +++ ++E E+ + + + RK+LE K+ +L +E
Sbjct: 836 LYFKIKPLLKSAE--------TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE 887
Query: 729 LTDLRVEKESLEKNLSERKKKSAQ---ERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVS 785
DL+++ ++ +L++ +++ Q + Q E +I E+ + ++E + +L K R
Sbjct: 888 KNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL 947
Query: 786 TDQAA-----AEQLSLVQAELQTQ---WEAKCEHL---LASAKDEHLQQYQEVCAQRDAY 834
D+ + + L L A+++ + E K ++L +A + + +E A ++A+
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 835 QQKLVQLQ----------EKCLALQAQITALTKQNEQHIK---ELEKNKSQMSGVEAAAS 881
QQ L LQ + + L+ Q+ L EQ K +LE+ K ++ G A
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ 1067
Query: 882 DPSEKVKKIMNQVFQSL-RREFE---LEESYNGRTILG-TIMNTIKMVTLQLLNQQEQEK 936
+ + ++ Q+ + L ++EFE L+ LG + IK + ++ +E+ +
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE 1127
Query: 937 EESSSEEEEEKAEERPRRPSQEQS----ASASSGQPQAPLNRERPESPMVPSEQVVEEAV 992
E +S + EK R +E S + + Q +N++R E+ + +EEA
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDLEEAT 1186
Query: 993 PLPPQALTTSQDGHRRKGDSEAEALSEI 1020
Q T+ ++ DS AE +I
Sbjct: 1187 ---LQHEATAATLRKKHADSVAELGEQI 1211
Score = 63.5 bits (153), Expect = 1e-09
Identities = 70/373 (18%), Positives = 162/373 (43%), Gaps = 30/373 (8%)
Query: 519 IRMAVSKVADKMDH-LMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERL 577
I++ +++V ++D + K EE+ + + ++ SM T++ + N I+ +++
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRN--DAIRLKKKM 1622
Query: 578 KQEILEKSNRIEEQNDKISELIE--------------------RNQRYVEQSNLMMEKRN 617
+ ++ E ++ N +E + R+Q +++ M+E+R
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRA 1682
Query: 618 NSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESL 677
N LQ E +A + E+ + +EL A+ +V L + T+ + +L+ +++
Sbjct: 1683 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQ 1742
Query: 678 KETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKE 737
E + + + + K + + + K E+ LE +LE+ + DL+ +
Sbjct: 1743 GEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802
Query: 738 SLEKNLSERKKKSAQERS----QAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
E+ + KK Q+ + E E++ +K E + LR+ +K + T Q ++
Sbjct: 1803 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR 1862
Query: 794 LSLVQ-AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQI 852
++++ +L + +AK + A++ Q + R Q +L + +E+ ++Q+
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFR-RIQHELEEAEERADIAESQV 1921
Query: 853 TAL-TKQNEQHIK 864
L K E H K
Sbjct: 1922 NKLRVKSREVHTK 1934
Score = 61.2 bits (147), Expect = 6e-09
Identities = 89/480 (18%), Positives = 194/480 (40%), Gaps = 45/480 (9%)
Query: 511 EARQHNTEIRMAVSKVADKMDHLMTK--------VEELQKHSAGNSMLIPSMSVTMETSM 562
E ++ E++ A+SK ++ TK EEL++ + + +E
Sbjct: 1353 EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA-- 1410
Query: 563 IMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQT 622
+ + + + +RL+ E+ + +E N + L ++ QR ++ +++
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL-DKKQRNFDKILAEWKQKCEETHA 1469
Query: 623 ATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL 682
E +Q E K+ + Q+ L+ + Q++ ++L Q+ E K
Sbjct: 1470 ELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1529
Query: 683 LRGQLTKVQAKLSELQETSEQAQSKFKSEK-----------QNRKQLELKVTSLEEELTD 731
L +V+ + SELQ E+A++ + E+ Q + +++ K+ +EE+
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1589
Query: 732 LRVEK----ESLEKNLSER----------KKKSAQERSQAEEEIDEIRKSYQEELDKLRQ 777
++ ES++ L KKK + ++ E +++ + E L R
Sbjct: 1590 MKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1649
Query: 778 ---LLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAY 834
+LK T++ D A Q L + + A +LL + +E ++ R
Sbjct: 1650 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRA---NLLQAEIEELRATLEQTERSRKIA 1706
Query: 835 QQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKK-IMNQ 893
+Q+L+ E+ L Q T+L ++ ++ + + +M + A + EK KK I +
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766
Query: 894 VFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPR 953
+ + E + S + + + T+K LQ + ++ +++ +K E R R
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVK--DLQHRLDEAEQLALKGGKKQIQKLEARVR 1824
Score = 50.8 bits (120), Expect = 8e-06
Identities = 50/234 (21%), Positives = 106/234 (45%), Gaps = 17/234 (7%)
Query: 525 KVADKMDHLMTKVEELQK-HSAGNSMLIPSMSVTMETSMIMSNIQRIIQE----NERLKQ 579
K+A++ L+ E +Q H+ S++ + + S I ++ IIQE E+ K+
Sbjct: 1704 KIAEQ--ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKK 1761
Query: 580 EILEKSNRIEE--QNDKISELIERNQRYVEQSNLMMEKR-NNSLQTATENTQARVLHAEQ 636
I + + EE + S +ER ++ +EQ+ ++ R + + Q A + + ++ E
Sbjct: 1762 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA 1821
Query: 637 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSE 696
++ E+ + + + H++K EL Q E K L+ + K+QAK+
Sbjct: 1822 RVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1881
Query: 697 LQETSEQAQ-------SKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNL 743
+ +E+A+ SKF+ + ++ E + E ++ LRV+ + +
Sbjct: 1882 YKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 82.8 bits (203), Expect = 2e-15
Identities = 120/505 (23%), Positives = 224/505 (44%), Gaps = 57/505 (11%)
Query: 523 VSKVADKMDHLMTKVEELQ------KHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENER 576
+ K+ + L KVE L+ K S N + S + E + + I+ + + +ER
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL-SKDLMKEKAQLEKTIETLRENSER 551
Query: 577 LKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQ 636
+ +ILE+ N E N +S L +R+Q E +EK N L + + T +++ E
Sbjct: 552 -QIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 637 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSE 696
EK ++ +EL H + K ++ EL+ +L KE +LL+ ++T ++ +
Sbjct: 609 EKRQIKKEL-------EHYKEK----GERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 697 L----QETS--EQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKS 750
+ QE S E+ K K + K L ++ SLE+E + L E L +N+ E K +
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV-ESLKCA 716
Query: 751 AQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTD--QAAAEQLSLVQAELQTQWE-- 806
+ + +Q + E E+ +S +E+L K +LLK + T+ + + + L + LQ E
Sbjct: 717 SMKMAQLQLENKEL-ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 807 -AKCEHLLASAKDEHL--QQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHI 863
K + L + +D + Q Q+ + ++L QL+++ +L+ + + L K +Q
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
Query: 864 KE--------------LEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN 909
KE LE+N ++ +E S+++ + E E +E
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 910 GRTILGTIMNTIK--MVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQ 967
TI + T++ +V+ +L QQ E + E E+ + R EQS
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST-----D 950
Query: 968 PQAPLNRERPESPMVPSEQVVEEAV 992
+ L + ES + S ++ EE +
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKI 975
Score = 80.1 bits (196), Expect = 1e-14
Identities = 111/504 (22%), Positives = 218/504 (43%), Gaps = 81/504 (16%)
Query: 514 QHNTEIRMAVSKVADKMD-HLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQ 572
Q N + VS + + +V++++K N +L S+ ETS S + +I
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKE---NKILHESIK---ETS---SKLSKIEF 608
Query: 573 ENERLKQEI---LEKSNRIEEQNDKISELIERNQ----------------RYVEQSNLMM 613
E ++K+E+ EK R EE +++ L + N+ +EQ N +
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 614 EKRNNSLQTATE---NTQARVLHAEQEKAKVTEE----------LAAATAQVSHLQLKMT 660
E+ N L+ + N ++ E+E +++ EE L A+ +++ LQL+
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 661 AHQKKETELQMQLT---ESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQ 717
+ ++ +L+ L S K+T+ L + + LQ+T E + K + + +
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 718 LELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQ 777
LE++ +L++ L +L++ + LE+ L + K QE SQ E++ +K ++E +LRQ
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQ-LEKENKSLEQETSQLEKD----KKQLEKENKRLRQ 843
Query: 778 L--LKKTRVSTDQAAAEQLSLVQAELQTQ---WEAKCEHLLASAKDEHLQQYQEVCAQRD 832
+K T + + L L + ++ C L K+ +E+ +
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-----KELVKRAT 898
Query: 833 AYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEK---NKSQMSGVEAAASDPSEKVKK 889
+ LV L+E ++ + + + E+ ELEK NK ++ E + D + K
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD---RYKL 955
Query: 890 IMNQVFQSLRREFE------------LEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKE 937
+ +++ +L++ E LEES N L + T+K L +Q++E+
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1015
Query: 938 ESSS---EEEEEKAEERPRRPSQE 958
SS E+ K E + ++E
Sbjct: 1016 VQSSPPISGEDNKWERESQETTRE 1039
Score = 68.2 bits (165), Expect = 5e-11
Identities = 93/418 (22%), Positives = 178/418 (42%), Gaps = 50/418 (11%)
Query: 498 FQGSGDMASFLMTEARQHNTEIRMAVSKVAD-KMDH--LMTKVEELQKHSAGNSMLIP-S 553
+QG L N +I+ S++ D +M++ L +EEL+ S L +
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 554 MSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMM 613
S+ ETS + + +++ +EN+RL+Q+ K +EE N KI L + N+ ++ +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 614 EKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQL 673
E + R+ E+E ++ + + T K L+ L
Sbjct: 878 E------------SCVRLKELEKENKELVK--------------RATIDIKTLVTLREDL 911
Query: 674 TESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLR 733
+T + L K+ +L ++ E+ +S K LE K+ S ++ +++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 734 VEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQ 793
EK + L R ++S Q +E+ ++K+Y E K RQ D+ Q
Sbjct: 972 EEKIAA---LEARLEESTNYNQQLRQELKTVKKNY--EALKQRQ---------DEERMVQ 1017
Query: 794 LSLVQAELQTQWEAKCEHL---LASAKDEHLQQYQE---VCAQRDAYQQKLVQLQEKCLA 847
S + +WE + + L KD ++ + + A++ A + +L QL+ +
Sbjct: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1077
Query: 848 LQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELE 905
LQAQI AL +Q ++ ++Q + ++ S + + +MNQ Q L ++ LE
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Score = 65.5 bits (158), Expect = 3e-10
Identities = 104/462 (22%), Positives = 193/462 (41%), Gaps = 63/462 (13%)
Query: 518 EIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSN----------- 566
E + V K+ ++ ++ +++ + A L V +ET ++ +
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDK 376
Query: 567 IQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN 626
+ + +EN +LK ++ + + KI EL+E N +L+ A +
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM---------------TLEMAQKQ 421
Query: 627 TQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTES-LKETDLLRG 685
+ LH E +++ T+++S K H+ E LT S L + ++
Sbjct: 422 SMDESLHLGWELEQISR-----TSELSEAPQKSLGHEVNE------LTSSRLLKLEMENQ 470
Query: 686 QLTKVQAKLSELQETSEQAQSKF-KSEKQNRKQLELKVTSLEEELT-------------- 730
LTK +L ++ E SK K EK+N++ L KV LE E+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQR-LSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 731 DLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAA 790
DL EK LEK + ++ S ++ E+E + + ++ L + Q+ + RV +
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKE 588
Query: 791 AEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQA 850
+ L E ++ +K E K E L+ Y+E + + + +L L+++ LQ
Sbjct: 589 NKILHESIKETSSKL-SKIEFEKRQIKKE-LEHYKEKGERAEELENELHHLEKENELLQK 646
Query: 851 QITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYN- 909
+IT L K + I+ LE+ S++ + K + Q+ +SL +E + N
Sbjct: 647 KITNL-KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKENSQLDEENL 704
Query: 910 --GRTILGTIMNTIKMVTLQLLNQQ-EQEKEESSSEEEEEKA 948
R + ++KM LQL N++ E EKE+ E KA
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Score = 55.1 bits (131), Expect = 4e-07
Identities = 78/402 (19%), Positives = 165/402 (41%), Gaps = 53/402 (13%)
Query: 571 IQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR 630
++E+ Q++ ++ +++ + + + +++ + QS+ + +N + ++ T
Sbjct: 982 LEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 631 VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKV 690
+L + +V A A+ L+ ++ + + LQ Q+ ++T L+ Q T +
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
Query: 691 QAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESL----EKNLSER 746
Q + ++LQ + S+ S QL ++ +SLE E + E+E L + + +
Sbjct: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
Query: 747 KKKSAQERSQAEEEIDEIRK-------------SYQEELDKLRQLLKKTRVSTDQAAAEQ 793
+K QA E I K +++ D+ QLLK+ D
Sbjct: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED------ 1213
Query: 794 LSLVQAELQTQWEAKCEHLLASAKDEH--LQQYQEVCAQRDAYQQKLVQLQEKCLALQAQ 851
L+ + + E +L K+ +Y+++C + D QL ++ LQ
Sbjct: 1214 -------LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT- 1265
Query: 852 ITALTKQNEQHIKELEKN-KSQMSGVEAAASDPSEKVK-------KIMNQVFQSLRREFE 903
+ +++K L N K + + +EA S E+ + K+ NQ + +
Sbjct: 1266 -------DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1318
Query: 904 LEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEE 945
LEE R +L I T+ + LL Q + K+ E+ +
Sbjct: 1319 LEE--ENRHLLDQI-QTLMLQNRTLLEQNMESKDLFHVEQRQ 1357
Score = 54.3 bits (129), Expect = 7e-07
Identities = 70/337 (20%), Positives = 151/337 (44%), Gaps = 32/337 (9%)
Query: 630 RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTK 689
R++ E ++ EL+ + L ++ Q M+ TES + + +L
Sbjct: 199 RLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV---ELAD 255
Query: 690 VQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDL-------RVEKESLE-- 740
+AK+ L++ E+ + KQ +Q+E+++ L++E +L R+ ++ L+
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 741 KNLSERKKKSAQERSQAEEEIDEIR--KSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQ 798
+ + R K E S+ +E + +I K+ EEL + Q+L +T+ + +QL +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE----DQLEGTR 371
Query: 799 AELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQ 858
A E + E+L AK ++ +RD ++K+ +L E+ + L+ KQ
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEM------ERDMDRKKIEELMEENMTLE----MAQKQ 421
Query: 859 NEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTI--LGT 916
+ L Q+S + P + + +N++ S + E+E +T+ L T
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 917 IMNTIKMVTLQLLNQQEQEKEESSSEE--EEEKAEER 951
+++++ ++L +++ + S E E E +E+
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
Score = 41.2 bits (95), Expect = 0.006
Identities = 55/273 (20%), Positives = 116/273 (42%), Gaps = 43/273 (15%)
Query: 510 TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
T N ++ + S + ++ + ++ + E+L+ S +S++ + + S +
Sbjct: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLK--SLYDSLIKDHEKLELLHERQASEYES 1175
Query: 570 IIQENERLK----------QEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS 619
+I ++ LK +++ ++ N++ +Q ++ +L VEQ +++E +N+
Sbjct: 1176 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL--EKMLKVEQEKMLLENKNHE 1233
Query: 620 LQTATENTQA----RVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKK--ETELQMQ- 672
A R+ H + K TE L Q H LK + K +T L+ +
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVL-----QTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 673 --LTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSE-----KQNRKQLELKVTSL 725
L E ++ D+ +L LS+L+ E+ + QNR LE + S
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 726 E----------EELTDLRVEKESLEKNLSERKK 748
+ ++L +LR +KE LE+ + ++ K
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,779,327
Number of Sequences: 37866
Number of extensions: 2557832
Number of successful extensions: 39743
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 1860
Number of HSP's that attempted gapping in prelim test: 18043
Number of HSP's gapped (non-prelim): 12071
length of query: 1219
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1105
effective length of database: 13,930,794
effective search space: 15393527370
effective search space used: 15393527370
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.