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Search of human proteins with 150010540
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150010540 FERM domain containing 4B [Homo sapiens]
(1034 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150010540 FERM domain containing 4B [Homo sapiens] 2084 0.0
gi|116063562 FERM domain containing 4A [Homo sapiens] 850 0.0
gi|4506467 radixin [Homo sapiens] 155 2e-37
gi|4505257 moesin [Homo sapiens] 152 1e-36
gi|161702986 ezrin [Homo sapiens] 151 4e-36
gi|21614499 ezrin [Homo sapiens] 151 4e-36
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 150 5e-36
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 150 5e-36
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 150 5e-36
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 150 5e-36
gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo sa... 142 2e-33
gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo s... 142 2e-33
gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens] 141 3e-33
gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo s... 140 8e-33
gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo s... 140 8e-33
gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens] 139 1e-32
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 127 7e-29
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 111 4e-24
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 111 4e-24
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 108 3e-23
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 108 3e-23
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 107 4e-23
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 107 4e-23
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 107 4e-23
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 105 2e-22
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 104 5e-22
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 103 6e-22
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 102 1e-21
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 102 1e-21
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 102 1e-21
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 2084 bits (5400), Expect = 0.0
Identities = 1034/1034 (100%), Positives = 1034/1034 (100%)
Query: 1 MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRH 60
MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRH
Sbjct: 1 MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRH 60
Query: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV
Sbjct: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
Query: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL
Sbjct: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
Query: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ
Sbjct: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
Query: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE
Sbjct: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
Query: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR 360
NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR
Sbjct: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR 360
Query: 361 KQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSE 420
KQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSE
Sbjct: 361 KQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSE 420
Query: 421 EQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR 480
EQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR
Sbjct: 421 EQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR 480
Query: 481 VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD 540
VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD
Sbjct: 481 VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD 540
Query: 541 AMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQ 600
AMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQ
Sbjct: 541 AMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQ 600
Query: 601 RSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG 660
RSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG
Sbjct: 601 RSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG 660
Query: 661 RSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRS 720
RSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRS
Sbjct: 661 RSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRS 720
Query: 721 SSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMP 780
SSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMP
Sbjct: 721 SSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMP 780
Query: 781 NLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYR 840
NLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYR
Sbjct: 781 NLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYR 840
Query: 841 SSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLR 900
SSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLR
Sbjct: 841 SSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLR 900
Query: 901 GWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNW 960
GWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNW
Sbjct: 901 GWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNW 960
Query: 961 RTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQ 1020
RTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQ
Sbjct: 961 RTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQ 1020
Query: 1021 RLFWHEDSKPGTLV 1034
RLFWHEDSKPGTLV
Sbjct: 1021 RLFWHEDSKPGTLV 1034
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 850 bits (2197), Expect = 0.0
Identities = 496/1009 (49%), Positives = 640/1009 (63%), Gaps = 101/1009 (10%)
Query: 55 MTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWL 114
MTEGR CQVHLLDDR+LELLVQPKLLA+ELLDLVASHFNLKEKEYFGI F D+TG NWL
Sbjct: 16 MTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWL 75
Query: 115 QLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVES 174
QLD RVL+HD PKK GP +L+F VRFYIESIS+LKD T+ELFFLNAK+C++K I+V+S
Sbjct: 76 QLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDS 135
Query: 175 ETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIK 234
E +F+LA++ILQEAKGD++S+E R DLK LPA PT+ L+EHPSLAYCEDRVIEHY K+
Sbjct: 136 EVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLN 195
Query: 235 GLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLF 294
G TRGQA+V YM IVE+LPTYGVHYYAVKDKQG+PWWLG+SYKGI QYD DKVKPRK+F
Sbjct: 196 GQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIF 255
Query: 295 QWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQH 354
QW+QLENLYFREKKF+VEVHDPRR SV+RRTFG SG+ V TWYA +LIKSIW MAISQH
Sbjct: 256 QWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQH 315
Query: 355 QFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQ 414
QFYLDRKQSK+KI +ARSL EIA+DLTETGT + SKL + +K + I S+GSL+SSGSQ
Sbjct: 316 QFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQ 375
Query: 415 DSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKP 474
+S+ S+ K++ + LK +++ L+E L +++EELKK+CLREAELTGK+P EYPL+ GE+P
Sbjct: 376 ESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEP 435
Query: 475 PQVRRRVGTAFKLDD-NLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKK 533
P VRRR+GTAFKLD+ +LP E+ L+ LE F IQ ++ EAA++LA++P++ K +KK+
Sbjct: 436 PIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQ 495
Query: 534 RKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPED-IIPSESSSLSDTTTYDDPS 592
RK Y +A+KKLQEIENAINE RI+ GKKP+Q+A+++ +D I SE SSLSD +D
Sbjct: 496 RKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDED 555
Query: 593 DAFTFPGQRSSSVPHSP------------RILPPKSL-GIERIHFRK------------- 626
T + S HSP R PP+SL G+ ++H+ +
Sbjct: 556 SQVT----STISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKMW 611
Query: 627 --SSINEQF--VDTRQSREMLSTHSSPYKTLERRPQGG-------------------RSM 663
SS++E + V R S S+H T GG SM
Sbjct: 612 SESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSM 671
Query: 664 PTTP---------VLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLL-SEMDSDKPFFS 713
P+TP V + + S S + H R RS SLESQ LL SE D+ P F
Sbjct: 672 PSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFY 731
Query: 714 LSKSQRSSSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQN--- 770
+++ S+ ++ +DD SS TS SS+E+Y + Y+T D+ ++ R+R +++
Sbjct: 732 TPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNA-NYSTLAEDSPSKARQRQRQRQRAA 790
Query: 771 --VSTSNSGSMPNLAQK------DSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGG 822
+ +++SGSMPNLA + GVY SQ PSS Y I Y Y E
Sbjct: 791 GALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVVV 850
Query: 823 YVYENDTEGQYSVNPSYRSSAHY---GYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKA 879
E+D EG YSV +++S Y G ++ E + R+ + LR P +
Sbjct: 851 RSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTP--S 908
Query: 880 AAKSEHITKNIHKALVAEHLRGWYQR--ASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQV 937
+ K +A V++ LR WYQR AS ++ S +S SD GSQ V
Sbjct: 909 LGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFV 968
Query: 938 P----------CSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYETPAH 976
C +S A S SST +S IG + +P H
Sbjct: 969 AHSRVTRMPQMCKATSAALPQSQRSSTPSS-------EIGATPPSSPHH 1010
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 155 bits (391), Expect = 2e-37
Identities = 117/484 (24%), Positives = 222/484 (45%), Gaps = 55/484 (11%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
D LE +QP ++L D V L+E +FG+ ++D G WL+L+ +V D+ K
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDV-K 71
Query: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
K P F +F+ E +S L + T LFFL K + +I ET LA++ +Q
Sbjct: 72 KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQ 131
Query: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
GDY + + L P + L++H + E+R+ + + +G+ R ++++Y
Sbjct: 132 AKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEY 191
Query: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
+KI + L YGV+Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 192 LKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFN 251
Query: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRKQSK 364
+KKF ++ D + +YA I K I + + H+ Y+ R++
Sbjct: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILALCMGNHELYMRRRK-- 296
Query: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQK- 423
P + ++ E Q+ + LE + + E++E++K
Sbjct: 297 ---PDTIEVQQMKAQAREEKHQKQLERAQLE---------------NEKKKREIAEKEKE 338
Query: 424 ---REKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR 480
REK EL ++ K ++E+ +K +EL++ + EL + ++ + R
Sbjct: 339 RIEREK-EELMERLKQIEEQTIKAQKELEEQTRKALELDQER---------KRAKEEAER 388
Query: 481 VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD 540
+ + + + A ++++ + +L E K+A L + KKK++++ T+
Sbjct: 389 LEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIA----LLEEAKKKKEEEATE 444
Query: 541 AMKK 544
K
Sbjct: 445 WQHK 448
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 152 bits (385), Expect = 1e-36
Identities = 144/606 (23%), Positives = 255/606 (42%), Gaps = 67/606 (11%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
D LE +QP ++L D V L+E +FG+ + D G WL+L+ +V D+ +
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDV-R 71
Query: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
K P + F +FY E +S L T LFFL K + I ET LA++ +Q
Sbjct: 72 KESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQ 131
Query: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
GD+ + + L P + L++H + E+R+ + + +G+ R AV++Y
Sbjct: 132 SKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEY 191
Query: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
+KI + L YGV+Y+++K+K+G WLG+ G+ Y+ D++ P+ F W ++ N+ F
Sbjct: 192 LKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFN 251
Query: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRKQSK 364
+KKF ++ D + +YA I K I + + H+ Y+ R++
Sbjct: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILALCMGNHELYMRRRK-- 296
Query: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424
P + ++ E Q+ + LE +E++KR
Sbjct: 297 ---PDTIEVQQMKAQAREEKHQKQMERAMLE-----------------------NEKKKR 330
Query: 425 EKILELKKKEKLLQEK-----LLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRR 479
E + K+KEK+ +EK LK++EE K +E E E E + +R
Sbjct: 331 E--MAEKEKEKIEREKEELMERLKQIEEQTKKAQQELE-------EQTRRALELEQERKR 381
Query: 480 RVGTAFKLDDNLLPSEE--DPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQD 537
A KL +EE + LQ Q++L +L + ++K++ +
Sbjct: 382 AQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESE 441
Query: 538 YTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFT- 596
+ +K Q ++ + + R S P + E + D +DA
Sbjct: 442 AVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAK 501
Query: 597 --FPGQRSSSVPHSPRILPP-KSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTL 653
+R++ + R+ K+L E + R S ++ + E + YKTL
Sbjct: 502 DRSEEERTTEAEKNERVQKHLKALTSELANARDES--KKTANDMIHAENMRLGRDKYKTL 559
Query: 654 ERRPQG 659
+ QG
Sbjct: 560 RQIRQG 565
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 151 bits (381), Expect = 4e-36
Identities = 105/407 (25%), Positives = 193/407 (47%), Gaps = 35/407 (8%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
D LE +QP ++L D V L+E YFG+ ++D+ G WL+LD +V ++ +
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71
Query: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
K P F +FY E ++ L T +LFFL K + +I ET L ++ +Q
Sbjct: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131
Query: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
GDY + + L + P + + +H + EDR+ + + +G+ + A+++Y
Sbjct: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191
Query: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
+KI + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251
Query: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRK--- 361
+KKF ++ D + +YA I K I + + H+ Y+ R+
Sbjct: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILQLCMGNHELYMRRRKPD 298
Query: 362 -----QSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDS 416
Q KA+ + ++ ET +R T+E + + +M L+
Sbjct: 299 TIEVQQMKAQAREEKHQKQLERQQLETEKKRRE---TVEREKEQMMREKEELMLRLQDYE 355
Query: 417 EVSEEQKRE------KILELKKKEKLLQEKLLKKVEELKKICLREAE 457
E +++ +RE + L+L+++ K QE+ +++E + LR E
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKE 401
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 151 bits (381), Expect = 4e-36
Identities = 105/407 (25%), Positives = 193/407 (47%), Gaps = 35/407 (8%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
D LE +QP ++L D V L+E YFG+ ++D+ G WL+LD +V ++ +
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71
Query: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
K P F +FY E ++ L T +LFFL K + +I ET L ++ +Q
Sbjct: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131
Query: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
GDY + + L + P + + +H + EDR+ + + +G+ + A+++Y
Sbjct: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191
Query: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
+KI + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251
Query: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRK--- 361
+KKF ++ D + +YA I K I + + H+ Y+ R+
Sbjct: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILQLCMGNHELYMRRRKPD 298
Query: 362 -----QSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDS 416
Q KA+ + ++ ET +R T+E + + +M L+
Sbjct: 299 TIEVQQMKAQAREEKHQKQLERQQLETEKKRRE---TVEREKEQMMREKEELMLRLQDYE 355
Query: 417 EVSEEQKRE------KILELKKKEKLLQEKLLKKVEELKKICLREAE 457
E +++ +RE + L+L+++ K QE+ +++E + LR E
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKE 401
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 150 bits (380), Expect = 5e-36
Identities = 123/489 (25%), Positives = 233/489 (47%), Gaps = 51/489 (10%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126
D +E + K ++L DLV L+E +FG+ + I DT WL++D +VLDHD+
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVLDHDVS 87
Query: 127 KKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFIL 185
K+ P HF +FY E+ L + T LFFL K + +I E LA++ +
Sbjct: 88 KEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 186 QEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAV 242
Q GDY + R L P + + Q P + E+R+ Y + +G R +A
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAE 204
Query: 243 VQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENL 302
++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+
Sbjct: 205 MEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI 264
Query: 303 YFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQ 362
+ +K+F ++ D ++I V + F S L V K I + I H ++ R++
Sbjct: 265 SYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRK 312
Query: 363 SKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQ 422
+ + + ++ E ++ + L + Q +++E + ++
Sbjct: 313 A-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDE 355
Query: 423 KREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVG 482
++L++K++ + E L++ EE + +A++T + K E +++R
Sbjct: 356 LERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKA 414
Query: 483 TAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYT 539
TA + +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++
Sbjct: 415 TAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAER 466
Query: 540 DAMKKLQEI 548
A +KL EI
Sbjct: 467 RAKQKLLEI 475
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 150 bits (380), Expect = 5e-36
Identities = 123/489 (25%), Positives = 233/489 (47%), Gaps = 51/489 (10%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126
D +E + K ++L DLV L+E +FG+ + I DT WL++D +VLDHD+
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVLDHDVS 87
Query: 127 KKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFIL 185
K+ P HF +FY E+ L + T LFFL K + +I E LA++ +
Sbjct: 88 KEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 186 QEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAV 242
Q GDY + R L P + + Q P + E+R+ Y + +G R +A
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAE 204
Query: 243 VQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENL 302
++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+
Sbjct: 205 MEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI 264
Query: 303 YFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQ 362
+ +K+F ++ D ++I V + F S L V K I + I H ++ R++
Sbjct: 265 SYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRK 312
Query: 363 SKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQ 422
+ + + ++ E ++ + L + Q +++E + ++
Sbjct: 313 A-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDE 355
Query: 423 KREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVG 482
++L++K++ + E L++ EE + +A++T + K E +++R
Sbjct: 356 LERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKA 414
Query: 483 TAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYT 539
TA + +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++
Sbjct: 415 TAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAER 466
Query: 540 DAMKKLQEI 548
A +KL EI
Sbjct: 467 RAKQKLLEI 475
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 150 bits (380), Expect = 5e-36
Identities = 123/489 (25%), Positives = 233/489 (47%), Gaps = 51/489 (10%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126
D +E + K ++L DLV L+E +FG+ + I DT WL++D +VLDHD+
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVLDHDVS 87
Query: 127 KKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFIL 185
K+ P HF +FY E+ L + T LFFL K + +I E LA++ +
Sbjct: 88 KEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 186 QEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAV 242
Q GDY + R L P + + Q P + E+R+ Y + +G R +A
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAE 204
Query: 243 VQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENL 302
++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+
Sbjct: 205 MEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI 264
Query: 303 YFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQ 362
+ +K+F ++ D ++I V + F S L V K I + I H ++ R++
Sbjct: 265 SYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRK 312
Query: 363 SKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQ 422
+ + + ++ E ++ + L + Q +++E + ++
Sbjct: 313 A-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDE 355
Query: 423 KREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVG 482
++L++K++ + E L++ EE + +A++T + K E +++R
Sbjct: 356 LERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKA 414
Query: 483 TAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYT 539
TA + +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++
Sbjct: 415 TAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAER 466
Query: 540 DAMKKLQEI 548
A +KL EI
Sbjct: 467 RAKQKLLEI 475
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 150 bits (380), Expect = 5e-36
Identities = 123/489 (25%), Positives = 233/489 (47%), Gaps = 51/489 (10%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126
D +E + K ++L DLV L+E +FG+ + I DT WL++D +VLDHD+
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVLDHDVS 87
Query: 127 KKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFIL 185
K+ P HF +FY E+ L + T LFFL K + +I E LA++ +
Sbjct: 88 KEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
Query: 186 QEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAV 242
Q GDY + R L P + + Q P + E+R+ Y + +G R +A
Sbjct: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAE 204
Query: 243 VQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENL 302
++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+
Sbjct: 205 MEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI 264
Query: 303 YFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQ 362
+ +K+F ++ D ++I V + F S L V K I + I H ++ R++
Sbjct: 265 SYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRK 312
Query: 363 SKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQ 422
+ + + ++ E ++ + L + Q +++E + ++
Sbjct: 313 A-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDE 355
Query: 423 KREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVG 482
++L++K++ + E L++ EE + +A++T + K E +++R
Sbjct: 356 LERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKA 414
Query: 483 TAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYT 539
TA + +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++
Sbjct: 415 TAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAER 466
Query: 540 DAMKKLQEI 548
A +KL EI
Sbjct: 467 RAKQKLLEI 475
>gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo
sapiens]
Length = 630
Score = 142 bits (357), Expect = 2e-33
Identities = 121/368 (32%), Positives = 189/368 (51%), Gaps = 47/368 (12%)
Query: 402 MASNGSLISSGSQDS------EVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLRE 455
M G LISS + ++ E + + K E++ L +++ LQE L K++EL+K+CL+E
Sbjct: 1 MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQE 60
Query: 456 AELTGKMPKEYPLNIGEKPPQVRRRVGTA--------FKLDDNLLPSEEDPALQELESNF 507
AELTG++P E PL GE+P VRRR TA + +L P+EE AL+ LE
Sbjct: 61 AELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEE-LALEALEREV 119
Query: 508 LIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKA 567
+QQ++ AA++LA PDL +++R+Q DA+++L E+E + + R R G
Sbjct: 120 SVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLP 179
Query: 568 TVLP-----------------------EDII-PSESSSLSDT-TTYDDPSDAFTFPGQRS 602
LP ED++ SESSSLS++ ++D+ F
Sbjct: 180 QPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAER 239
Query: 603 SSVPHSPRILPPKSLGI-ERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQG-- 659
S P + L S G ER K ++ + D + R +++ +SP ++L R
Sbjct: 240 PSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFE 299
Query: 660 GRSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHL-LSEMDSDKPFFSLSKSQ 718
GRS+P TPVLTR A +PE H RQ SGS +SQ ++ SD+ +++++
Sbjct: 300 GRSVPATPVLTRGA-GPQLCKPE--GLHSRQWSGSQDSQMGFPRADPASDRASLFVARTR 356
Query: 719 RSSSTEIL 726
RS+S+E L
Sbjct: 357 RSNSSEAL 364
>gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo
sapiens]
Length = 661
Score = 142 bits (357), Expect = 2e-33
Identities = 121/368 (32%), Positives = 189/368 (51%), Gaps = 47/368 (12%)
Query: 402 MASNGSLISSGSQDS------EVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLRE 455
M G LISS + ++ E + + K E++ L +++ LQE L K++EL+K+CL+E
Sbjct: 1 MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQE 60
Query: 456 AELTGKMPKEYPLNIGEKPPQVRRRVGTA--------FKLDDNLLPSEEDPALQELESNF 507
AELTG++P E PL GE+P VRRR TA + +L P+EE AL+ LE
Sbjct: 61 AELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEE-LALEALEREV 119
Query: 508 LIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKA 567
+QQ++ AA++LA PDL +++R+Q DA+++L E+E + + R R G
Sbjct: 120 SVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLP 179
Query: 568 TVLP-----------------------EDII-PSESSSLSDT-TTYDDPSDAFTFPGQRS 602
LP ED++ SESSSLS++ ++D+ F
Sbjct: 180 QPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAER 239
Query: 603 SSVPHSPRILPPKSLGI-ERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQG-- 659
S P + L S G ER K ++ + D + R +++ +SP ++L R
Sbjct: 240 PSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFE 299
Query: 660 GRSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHL-LSEMDSDKPFFSLSKSQ 718
GRS+P TPVLTR A +PE H RQ SGS +SQ ++ SD+ +++++
Sbjct: 300 GRSVPATPVLTRGA-GPQLCKPE--GLHSRQWSGSQDSQMGFPRADPASDRASLFVARTR 356
Query: 719 RSSSTEIL 726
RS+S+E L
Sbjct: 357 RSNSSEAL 364
>gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens]
Length = 663
Score = 141 bits (356), Expect = 3e-33
Identities = 101/298 (33%), Positives = 157/298 (52%), Gaps = 28/298 (9%)
Query: 393 TLEAKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKIC 452
T+E+K + +G ++ SG DS VS +E + K+++ L+ +L +EEL+++C
Sbjct: 85 TMESKDEVSDTDSGIILQSGP-DSPVSP--MKELTHAVHKQQRALEARLEACLEELRRLC 141
Query: 453 LREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQK 512
LREAELTG +P EYPL GEK P+VRRR+G A+KLDD L EDP L LE +Q +
Sbjct: 142 LREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL-HREDP-LSSLERQLALQLQ 199
Query: 513 LVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPE 572
+ EAA++L E +L + +++RK KKLQE++ + E R R + P A L
Sbjct: 200 ITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERR-RNSEPPPAAALPLGR 258
Query: 573 DIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSL--------------- 617
++ S+ SSLSD ++ P S + P P LPP++L
Sbjct: 259 ELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRP--LPPQTLEGLQPTGPEAGSPER 316
Query: 618 -GIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAY 674
++ ++++S++ + R+S E S SSP T PQ G S + +L +Y
Sbjct: 317 APVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATT----PQDGPSASSLWLLEPASY 370
>gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo
sapiens]
Length = 618
Score = 140 bits (352), Expect = 8e-33
Identities = 115/347 (33%), Positives = 180/347 (51%), Gaps = 41/347 (11%)
Query: 417 EVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQ 476
E + + K E++ L +++ LQE L K++EL+K+CL+EAELTG++P E PL GE+P
Sbjct: 10 EAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQL 69
Query: 477 VRRRVGTA--------FKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCK 528
VRRR TA + +L P+EE AL+ LE +QQ++ AA++LA PDL
Sbjct: 70 VRRRPPTARAYPPPHPNQAHHSLCPAEE-LALEALEREVSVQQQIAAAARRLALAPDLST 128
Query: 529 TVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLP----------------- 571
+++R+Q DA+++L E+E + + R R G LP
Sbjct: 129 EQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMR 188
Query: 572 ------EDII-PSESSSLSDT-TTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGI-ERI 622
ED++ SESSSLS++ ++D+ F S P + L S G ER
Sbjct: 189 LAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERR 248
Query: 623 HFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQG--GRSMPTTPVLTRNAYSSSHLE 680
K ++ + D + R +++ +SP ++L R GRS+P TPVLTR A +
Sbjct: 249 TPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGA-GPQLCK 307
Query: 681 PESSSQHCRQRSGSLESQSHL-LSEMDSDKPFFSLSKSQRSSSTEIL 726
PE H RQ SGS +SQ ++ SD+ +++++RS+S+E L
Sbjct: 308 PE--GLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEAL 352
>gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo
sapiens]
Length = 649
Score = 140 bits (352), Expect = 8e-33
Identities = 115/347 (33%), Positives = 180/347 (51%), Gaps = 41/347 (11%)
Query: 417 EVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQ 476
E + + K E++ L +++ LQE L K++EL+K+CL+EAELTG++P E PL GE+P
Sbjct: 10 EAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQL 69
Query: 477 VRRRVGTA--------FKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCK 528
VRRR TA + +L P+EE AL+ LE +QQ++ AA++LA PDL
Sbjct: 70 VRRRPPTARAYPPPHPNQAHHSLCPAEE-LALEALEREVSVQQQIAAAARRLALAPDLST 128
Query: 529 TVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLP----------------- 571
+++R+Q DA+++L E+E + + R R G LP
Sbjct: 129 EQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMR 188
Query: 572 ------EDII-PSESSSLSDT-TTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGI-ERI 622
ED++ SESSSLS++ ++D+ F S P + L S G ER
Sbjct: 189 LAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERR 248
Query: 623 HFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQG--GRSMPTTPVLTRNAYSSSHLE 680
K ++ + D + R +++ +SP ++L R GRS+P TPVLTR A +
Sbjct: 249 TPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGA-GPQLCK 307
Query: 681 PESSSQHCRQRSGSLESQSHL-LSEMDSDKPFFSLSKSQRSSSTEIL 726
PE H RQ SGS +SQ ++ SD+ +++++RS+S+E L
Sbjct: 308 PE--GLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEAL 352
>gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens]
Length = 578
Score = 139 bits (351), Expect = 1e-32
Identities = 100/297 (33%), Positives = 156/297 (52%), Gaps = 28/297 (9%)
Query: 394 LEAKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICL 453
+E+K + +G ++ SG DS VS +E + K+++ L+ +L +EEL+++CL
Sbjct: 1 MESKDEVSDTDSGIILQSGP-DSPVSP--MKELTHAVHKQQRALEARLEACLEELRRLCL 57
Query: 454 REAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQKL 513
REAELTG +P EYPL GEK P+VRRR+G A+KLDD L EDP L LE +Q ++
Sbjct: 58 REAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL-HREDP-LSSLERQLALQLQI 115
Query: 514 VEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPED 573
EAA++L E +L + +++RK KKLQE++ + E R R + P A L +
Sbjct: 116 TEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERR-RNSEPPPAAALPLGRE 174
Query: 574 IIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSL---------------- 617
+ S+ SSLSD ++ P S + P P LPP++L
Sbjct: 175 LSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRP--LPPQTLEGLQPTGPEAGSPERA 232
Query: 618 GIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAY 674
++ ++++S++ + R+S E S SSP T PQ G S + +L +Y
Sbjct: 233 PVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATT----PQDGPSASSLWLLEPASY 285
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 127 bits (318), Expect = 7e-29
Identities = 106/442 (23%), Positives = 208/442 (47%), Gaps = 48/442 (10%)
Query: 114 LQLDHRVLDHDLPKKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEV 172
++ + VLDHD+ K+ P HF +FY E+ L + T LFFL K + +I
Sbjct: 33 MEFNCEVLDHDVSKEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 91
Query: 173 ESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEH 229
E LA++ +Q GDY + R L P + + Q P + E+R+
Sbjct: 92 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAW 149
Query: 230 YLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVK 289
Y + +G R +A ++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++
Sbjct: 150 YAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLT 209
Query: 290 PRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVM 349
P+ F W ++ N+ + +K+F ++ D ++I V + F S L V K I +
Sbjct: 210 PKISFPWNEIRNISYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQL 257
Query: 350 AISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLI 409
I H ++ R+++ + + ++ E ++ + L + Q
Sbjct: 258 CIGNHDLFMRRRKA-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM--------- 303
Query: 410 SSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLN 469
+++E + ++ ++L++K++ + E L++ EE + +A++T + K
Sbjct: 304 ---REEAERTRDELERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQK 359
Query: 470 IGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDL 526
E +++R TA + +EE+ L E LE+ ++ K+ E +++ A E D
Sbjct: 360 AAEAEQEMQRIKATAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQ 411
Query: 527 CKTVKKKRKQDYTDAMKKLQEI 548
K ++ ++ A +KL EI
Sbjct: 412 LKQDLQEAREAERRAKQKLLEI 433
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 111 bits (277), Expect = 4e-24
Identities = 77/297 (25%), Positives = 134/297 (45%), Gaps = 21/297 (7%)
Query: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
C+V LLD E V+ + L DLV H NL EK+YFG+TF D Q+NWL +
Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
Query: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
+ P F V+FY + L + T L +A + G++ T L
Sbjct: 97 KKQ---IRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 153
Query: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
++ +Q GDY ++E+ + L P +T + E+R++E + +G+T G+
Sbjct: 154 GSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE-------LEERIMELHKTYRGMTPGE 206
Query: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
A + +++ + L YGV + KD +G+ LG+ G+ Y +D+++ + F W ++
Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY--RDRLRINR-FAWPKIL 263
Query: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY 357
+ ++ F +++ P T G N K +W + I H F+
Sbjct: 264 KISYKRSNFYIKIR-PGEYEQFESTIGFK-------LPNHRSAKRLWKVCIEHHTFF 312
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 111 bits (277), Expect = 4e-24
Identities = 77/297 (25%), Positives = 134/297 (45%), Gaps = 21/297 (7%)
Query: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
C+V LLD E V+ + L DLV H NL EK+YFG+TF D Q+NWL +
Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
Query: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
+ P F V+FY + L + T L +A + G++ T L
Sbjct: 159 KKQ---IRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 215
Query: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
++ +Q GDY ++E+ + L P +T + E+R++E + +G+T G+
Sbjct: 216 GSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE-------LEERIMELHKTYRGMTPGE 268
Query: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
A + +++ + L YGV + KD +G+ LG+ G+ Y +D+++ + F W ++
Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY--RDRLRINR-FAWPKIL 325
Query: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY 357
+ ++ F +++ P T G N K +W + I H F+
Sbjct: 326 KISYKRSNFYIKIR-PGEYEQFESTIGFK-------LPNHRSAKRLWKVCIEHHTFF 374
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 108 bits (270), Expect = 3e-23
Identities = 84/314 (26%), Positives = 137/314 (43%), Gaps = 23/314 (7%)
Query: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
C V LLDD +Q + L DL+ H NL EK+YFGI F+D Q++WL+ V
Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
Query: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
+ L +P P + F V+FY + LK++ T L FL K ++ G++ ++ L
Sbjct: 79 V-KQLRSQP-PFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALL 136
Query: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
AA+ILQ GDY S ++ FP + + +A H ++ G T
Sbjct: 137 AAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEI------HKTELSGQTPAT 190
Query: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
+ + +++ + L TYGV + KD G +L + G + + K +W ++
Sbjct: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFG---FVVLQGNKRVHFIKWNEVT 247
Query: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYA-NSSLIKSIWVMAISQHQFYLD 359
L F K F + V + + T++A K +W I FY
Sbjct: 248 KLKFEGKTFYLYVSQKEEKKI-----------ILTYFAPTPEACKHLWKCGIENQAFYKL 296
Query: 360 RKQSKAKIPSARSL 373
K S+ + S+ +L
Sbjct: 297 EKSSQVRTVSSSNL 310
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 108 bits (269), Expect = 3e-23
Identities = 107/488 (21%), Positives = 211/488 (43%), Gaps = 90/488 (18%)
Query: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126
D +E + K ++L DLV L+E +FG+ + I DT WL++D +V L
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVKKQILD 87
Query: 127 KKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
+K I E LA++ +Q
Sbjct: 88 EK-----------------------------------------IYCPPEASVLLASYAVQ 106
Query: 187 EAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAVV 243
GDY + R L P + + Q P + E+R+ Y + +G R +A +
Sbjct: 107 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAEM 164
Query: 244 QYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLY 303
+Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+
Sbjct: 165 EYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNIS 224
Query: 304 FREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQS 363
+ +K+F ++ D ++I V + F S L V K I + I H ++ R+++
Sbjct: 225 YSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRKA 272
Query: 364 KAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQK 423
+ + ++ E ++ + L + Q +++E + ++
Sbjct: 273 -----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDEL 315
Query: 424 REKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGT 483
++L++K++ + E L++ EE + +A++T + K E +++R T
Sbjct: 316 ERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKAT 374
Query: 484 AFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD 540
A + +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++
Sbjct: 375 AIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAERR 426
Query: 541 AMKKLQEI 548
A +KL EI
Sbjct: 427 AKQKLLEI 434
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 107 bits (268), Expect = 4e-23
Identities = 85/324 (26%), Positives = 142/324 (43%), Gaps = 23/324 (7%)
Query: 50 QDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTG 109
Q V + T+ C+V LLD ++ + L D V H NL EK+YFG+ F +
Sbjct: 209 QKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPE 268
Query: 110 QQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQ 169
Q+NWL + + P + F V+FY S L + T L + + G+
Sbjct: 269 QKNWLDPAKEI---KRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGR 325
Query: 170 IEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEH 229
+ T L ++ LQ GDY +E+ DL PT+T + E++V E
Sbjct: 326 LPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKE-------LEEKVAEL 378
Query: 230 YLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVK 289
+ +GL+ QA Q+++ + L YGV + KD +G+ LG+ G+ Y +D+++
Sbjct: 379 HKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY--KDRLR 436
Query: 290 PRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVM 349
+ F W ++ + ++ F ++V P + T G N K +W +
Sbjct: 437 INR-FAWPKILKISYKRSNFYIKVR-PAELEQFESTIGFK-------LPNHRAAKRLWKV 487
Query: 350 AISQHQFYLDRKQSKAKIPSARSL 373
+ H FY R S + P A+ L
Sbjct: 488 CVEHHTFY--RLVSPEQPPKAKFL 509
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 107 bits (268), Expect = 4e-23
Identities = 85/324 (26%), Positives = 142/324 (43%), Gaps = 23/324 (7%)
Query: 50 QDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTG 109
Q V + T+ C+V LLD ++ + L D V H NL EK+YFG+ F +
Sbjct: 209 QKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPE 268
Query: 110 QQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQ 169
Q+NWL + + P + F V+FY S L + T L + + G+
Sbjct: 269 QKNWLDPAKEI---KRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGR 325
Query: 170 IEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEH 229
+ T L ++ LQ GDY +E+ DL PT+T + E++V E
Sbjct: 326 LPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKE-------LEEKVAEL 378
Query: 230 YLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVK 289
+ +GL+ QA Q+++ + L YGV + KD +G+ LG+ G+ Y +D+++
Sbjct: 379 HKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY--KDRLR 436
Query: 290 PRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVM 349
+ F W ++ + ++ F ++V P + T G N K +W +
Sbjct: 437 INR-FAWPKILKISYKRSNFYIKVR-PAELEQFESTIGFK-------LPNHRAAKRLWKV 487
Query: 350 AISQHQFYLDRKQSKAKIPSARSL 373
+ H FY R S + P A+ L
Sbjct: 488 CVEHHTFY--RLVSPEQPPKAKFL 509
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 107 bits (268), Expect = 4e-23
Identities = 85/324 (26%), Positives = 142/324 (43%), Gaps = 23/324 (7%)
Query: 50 QDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTG 109
Q V + T+ C+V LLD ++ + L D V H NL EK+YFG+ F +
Sbjct: 209 QKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPE 268
Query: 110 QQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQ 169
Q+NWL + + P + F V+FY S L + T L + + G+
Sbjct: 269 QKNWLDPAKEI---KRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGR 325
Query: 170 IEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEH 229
+ T L ++ LQ GDY +E+ DL PT+T + E++V E
Sbjct: 326 LPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKE-------LEEKVAEL 378
Query: 230 YLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVK 289
+ +GL+ QA Q+++ + L YGV + KD +G+ LG+ G+ Y +D+++
Sbjct: 379 HKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY--KDRLR 436
Query: 290 PRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVM 349
+ F W ++ + ++ F ++V P + T G N K +W +
Sbjct: 437 INR-FAWPKILKISYKRSNFYIKVR-PAELEQFESTIGFK-------LPNHRAAKRLWKV 487
Query: 350 AISQHQFYLDRKQSKAKIPSARSL 373
+ H FY R S + P A+ L
Sbjct: 488 CVEHHTFY--RLVSPEQPPKAKFL 509
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 105 bits (262), Expect = 2e-22
Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 20/298 (6%)
Query: 61 CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV 120
C+V LLD + + + K +EL D + H +L E +YFG+ F+D +WL +
Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104
Query: 121 LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL 180
K P LH V+FY + L+++ T LF L K + G+++ +T +L
Sbjct: 105 KKQ--VKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQL 162
Query: 181 AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ 240
AA+ LQ GDY E++ + + P +T E LA + E + + +G T Q
Sbjct: 163 AAYNLQAELGDYDLAEHSPELVSEFRFVPIQT--EEMELA-----IFEKWKEYRGQTPAQ 215
Query: 241 AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE 300
A Y+ + L YGV + VK + G + LG++ G+ ++ K+ LF W ++
Sbjct: 216 AETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKI---GLFFWPKIT 272
Query: 301 NLYFREKKFA-VEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY 357
L F++ K V V D + TF + K +W A+ H F+
Sbjct: 273 RLDFKKNKLTLVVVEDDDQGKEQEHTF-------VFRLDHPKACKHLWKCAVEHHAFF 323
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 104 bits (259), Expect = 5e-22
Identities = 90/378 (23%), Positives = 157/378 (41%), Gaps = 35/378 (9%)
Query: 52 VYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQ 111
+ + + C+V LLD V+ + + L D V H NL EK+YFG+T+ D Q+
Sbjct: 103 IVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQK 162
Query: 112 NWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIE 171
NWL + + G F V+FY + L + T L + + G++
Sbjct: 163 NWLDPAKEIKKQ---VRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLP 219
Query: 172 VESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYL 231
T+ L ++ +Q GDY DE + P T + ED+VIE +
Sbjct: 220 CSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKE-------LEDKVIELHK 272
Query: 232 KIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPR 291
+G+T +A + +++ + L YGV + KD +G+ LG+ G+ Y +D+++
Sbjct: 273 SHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIY--RDRLRIN 330
Query: 292 KLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAI 351
+ F W ++ + ++ F +++ P T G N K +W + +
Sbjct: 331 R-FAWPKVLKISYKRNNFYIKIR-PGEFEQFESTIGFK-------LPNHRAAKRLWKVCV 381
Query: 352 SQHQFYLDRKQSKAKIPSARSLDEIAM-------DLTETGTQRASKLVTLEAKSQFIMAS 404
H F+ + +P A + + T+ T+RAS L+ A F +S
Sbjct: 382 EHHTFF------RLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPA-PYFERSS 434
Query: 405 NGSLISSGSQDSEVSEEQ 422
+ S S D EV Q
Sbjct: 435 SKRYTMSRSLDGEVGTGQ 452
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 103 bits (258), Expect = 6e-22
Identities = 75/296 (25%), Positives = 134/296 (45%), Gaps = 17/296 (5%)
Query: 62 QVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVL 121
++ LL++ +E + + +E L+ VA L+E YF + + + Q+ W+ L+ + L
Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLE-KPL 84
Query: 122 DHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLA 181
L K ++F V FY+ S+S L+ + T ++L K + +G I E +LA
Sbjct: 85 KKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLA 144
Query: 182 AFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQA 241
+Q GD+ E+ + L+ FP LQ+ L +V + K +GLT A
Sbjct: 145 GLAVQADFGDFDQYES-QDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDA 203
Query: 242 VVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLEN 301
+ YM+ VE + YG Y KD QG +G +GI + + +F+W + N
Sbjct: 204 EMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGI--FVKHKNGRHPVVFRWHDIAN 261
Query: 302 LYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY 357
+ + FA+E+ + +Q + K IW + +++H+FY
Sbjct: 262 MSHNKSFFALELANKEET-------------IQFQTEDMETAKYIWRLCVARHKFY 304
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 102 bits (255), Expect = 1e-21
Identities = 99/427 (23%), Positives = 197/427 (46%), Gaps = 55/427 (12%)
Query: 137 AVRFYIESISFLKDKT-TVELFFLNAKA---CVHKGQIEVES-----ETIFKLAAFILQE 187
A R S+ + KT TV + ++A+ C K QI E E LA++ +Q
Sbjct: 6 ASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQA 65
Query: 188 AKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQ 244
GDY + R L P + + Q P + E+R+ Y + +G R +A ++
Sbjct: 66 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAEME 123
Query: 245 YMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYF 304
Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+ +
Sbjct: 124 YLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISY 183
Query: 305 REKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSK 364
+K+F ++ D ++I V + F S L V K I + I H ++ R+++
Sbjct: 184 SDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRKA- 230
Query: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424
+ + ++ E ++ + L + Q +++E + ++
Sbjct: 231 ----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELE 274
Query: 425 EKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTA 484
++L++K++ + E L++ EE + +A++T + K E +++R TA
Sbjct: 275 RRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATA 333
Query: 485 FKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDA 541
+ +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++ A
Sbjct: 334 IR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAERRA 385
Query: 542 MKKLQEI 548
+KL EI
Sbjct: 386 KQKLLEI 392
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 102 bits (255), Expect = 1e-21
Identities = 99/427 (23%), Positives = 197/427 (46%), Gaps = 55/427 (12%)
Query: 137 AVRFYIESISFLKDKT-TVELFFLNAKA---CVHKGQIEVES-----ETIFKLAAFILQE 187
A R S+ + KT TV + ++A+ C K QI E E LA++ +Q
Sbjct: 6 ASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQA 65
Query: 188 AKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQ 244
GDY + R L P + + Q P + E+R+ Y + +G R +A ++
Sbjct: 66 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAEME 123
Query: 245 YMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYF 304
Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+ +
Sbjct: 124 YLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISY 183
Query: 305 REKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSK 364
+K+F ++ D ++I V + F S L V K I + I H ++ R+++
Sbjct: 184 SDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRKA- 230
Query: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424
+ + ++ E ++ + L + Q +++E + ++
Sbjct: 231 ----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELE 274
Query: 425 EKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTA 484
++L++K++ + E L++ EE + +A++T + K E +++R TA
Sbjct: 275 RRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATA 333
Query: 485 FKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDA 541
+ +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++ A
Sbjct: 334 IR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAERRA 385
Query: 542 MKKLQEI 548
+KL EI
Sbjct: 386 KQKLLEI 392
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 102 bits (255), Expect = 1e-21
Identities = 72/301 (23%), Positives = 140/301 (46%), Gaps = 19/301 (6%)
Query: 62 QVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVL 121
++ LLD +E + + +E L+ VA L+E YFG+ F+ + Q W++L+ +
Sbjct: 24 RIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLK 83
Query: 122 DHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLA 181
H L K +L F V FY+ ++S+L+ + T ++L K V +G++ + + +LA
Sbjct: 84 KH-LDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLA 142
Query: 182 AFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQA 241
+Q GDY + +++ L+ FP E L +V + + G+ +A
Sbjct: 143 GLAVQADFGDY-NQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEA 201
Query: 242 VVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKV-KPRKLFQWKQLE 300
+ Y+ VE L +G + VKD G LGI + GI +++++ + +++W +
Sbjct: 202 ELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGI---FVRNRIGRQAVIYRWNDMG 258
Query: 301 NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR 360
N+ + VE+ + ++ LF N+ I ++ ++H+FY
Sbjct: 259 NITHNKSTILVELINKE----------ETALFHTDDIENAKYISRLFA---TRHKFYKQN 305
Query: 361 K 361
K
Sbjct: 306 K 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,773,686
Number of Sequences: 37866
Number of extensions: 1851730
Number of successful extensions: 7243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 252
Number of HSP's that attempted gapping in prelim test: 6436
Number of HSP's gapped (non-prelim): 878
length of query: 1034
length of database: 18,247,518
effective HSP length: 112
effective length of query: 922
effective length of database: 14,006,526
effective search space: 12914016972
effective search space used: 12914016972
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.