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Search of human proteins with 149999365
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149999365 matrix metalloproteinase 16 isoform 2
preproprotein [Homo sapiens]
(457 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein... 976 0.0
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ... 872 0.0
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] 571 e-163
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] 477 e-134
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] 466 e-131
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 272 5e-73
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] 244 1e-64
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap... 241 8e-64
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] 239 3e-63
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi... 234 9e-62
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] 234 1e-61
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi... 226 3e-59
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] 220 2e-57
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi... 214 1e-55
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H... 212 5e-55
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] 205 6e-53
gi|73808268 matrix metalloproteinase 27 [Homo sapiens] 204 1e-52
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ... 193 2e-49
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] 180 2e-45
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot... 164 2e-40
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 142 5e-34
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] 137 3e-32
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [... 137 3e-32
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 129 7e-30
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi... 102 7e-22
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] 101 2e-21
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens] 79 1e-14
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ... 76 6e-14
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens] 76 6e-14
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens] 75 9e-14
>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
[Homo sapiens]
Length = 457
Score = 976 bits (2524), Expect = 0.0
Identities = 457/457 (100%), Positives = 457/457 (100%)
Query: 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
Sbjct: 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
Query: 61 SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
Sbjct: 61 SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
Query: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
Sbjct: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
Query: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
Sbjct: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
Query: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
Sbjct: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
Query: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
Sbjct: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSIIQDGW 420
KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSIIQDGW
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSIIQDGW 420
Query: 421 LYKYHWKWILEQRQSVPVLSRQTEKHKTYEELSSITY 457
LYKYHWKWILEQRQSVPVLSRQTEKHKTYEELSSITY
Sbjct: 421 LYKYHWKWILEQRQSVPVLSRQTEKHKTYEELSSITY 457
>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
[Homo sapiens]
Length = 607
Score = 872 bits (2253), Expect = 0.0
Identities = 407/407 (100%), Positives = 407/407 (100%)
Query: 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
Sbjct: 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
Query: 61 SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
Sbjct: 61 SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
Query: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
Sbjct: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
Query: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
Sbjct: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
Query: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
Sbjct: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
Query: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
Sbjct: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
Score = 33.9 bits (76), Expect = 0.32
Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 358 FVFKDQWFWRVRNN-RVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
+ FK +WR + MD GYP IT W+G+P S + + + F +F
Sbjct: 452 YFFKGDRYWRYSEEMKTMDPGYPKPITV-WKGIPESPQGAFVHKENGFTYF 501
>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
Length = 645
Score = 571 bits (1471), Expect = e-163
Identities = 268/371 (72%), Positives = 305/371 (82%), Gaps = 3/371 (0%)
Query: 38 EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97
E F + WL+ YGYL P D R S L SA+ +QSA++ MQQFYGI +TG +D+ TI+WMK
Sbjct: 76 EAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMK 135
Query: 98 KPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFD 157
KPRCGVPD S + R KRYALTGQKW+ KHITYSI N TPKVG+ +TRKAIR+AFD
Sbjct: 136 KPRCGVPDHPHLSRRR--RNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFD 193
Query: 158 VWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 217
VWQ VTPLTFEEVPY E+++ +++ DI I FASGFHGDSSPFDGEGGFLAHAYFPGPGIG
Sbjct: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 253
Query: 218 GDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK 277
GDTHFDSDEPWTLGN NHDGNDLFLVAVHELGHALGLEHS+DP+AIMAPFYQYMET NFK
Sbjct: 254 GDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFK 313
Query: 278 LPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTG-RPSYP 336
LP DDLQGIQKIYGPP + PTRPLPT+P R P++ + +P+PPRPP G RPS P
Sbjct: 314 LPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP 373
Query: 337 GAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVY 396
G KPNICDGNFNT+A+ R EMFVFKD+WFWR+RNNRV +GYPMQI FW+GLP IDA Y
Sbjct: 374 GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAY 433
Query: 397 ENSDGNFVFFK 407
E +DG FVFFK
Sbjct: 434 ERADGRFVFFK 444
Score = 33.1 bits (74), Expect = 0.54
Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 358 FVFKDQWFWRVRNNR--VMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
+ FK + +WR R GYP IT W+G+P + + + +G + +F
Sbjct: 489 YFFKGERYWRYSEERRATDPGYPKPITV-WKGIPQAPQGAFISKEGYYTYF 538
>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
Length = 669
Score = 477 bits (1227), Expect = e-134
Identities = 234/404 (57%), Positives = 286/404 (70%), Gaps = 21/404 (5%)
Query: 23 LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
L LL L V + + E WL+ YGYLP MS +RSA+ + SALA MQ+FYGI
Sbjct: 33 LLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGI 92
Query: 83 NMTGKVDRNTIDWMKKPRCGVPDQ--TRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVT 140
+TG +D T +WMK+PRCGVPDQ R + RRKRYALTG+KW + H+T+SI+N T
Sbjct: 93 PVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYT 152
Query: 141 PKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELE-NGKRDVDITIIFASGFHGDSSPF 199
K+G + +A+RRAF VW+ TPL F+EVPY ++ +++ DI ++FASGFHGDSSPF
Sbjct: 153 EKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPF 212
Query: 200 DGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSND 259
DG GGFLAHAYFPGPG+GGDTHFD+DEPWT + + GN+LFLVAVHELGHALGLEHS++
Sbjct: 213 DGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSN 272
Query: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTV-----------PP 308
P AIMAPFYQ+ + DNFKLP DDL+GIQ++YG PD P PT+PLPTV PP
Sbjct: 273 PNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPP 332
Query: 309 HRSIPPADPRKNDRPKPPRPP-----TGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQ 363
PP K +RP P PP T RP G PNICDG+F+T+A+LR EMFVFK +
Sbjct: 333 RPPQPPPPGGKPERPPKPGPPVQPRATERPDQYG--PNICDGDFDTVAMLRGEMFVFKGR 390
Query: 364 WFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
WFWRVR+NRV+D YPM I +FWRGLP I A YE DG FVFFK
Sbjct: 391 WFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFK 434
Score = 30.8 bits (68), Expect = 2.7
Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 358 FVFKDQWFWRVRNN--RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
F F++ +WR R GYP I+ W+G+P S + ++D + +F
Sbjct: 479 FFFQEDRYWRFNEETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYTYF 528
>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
Length = 582
Score = 466 bits (1198), Expect = e-131
Identities = 230/416 (55%), Positives = 287/416 (68%), Gaps = 20/416 (4%)
Query: 23 LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
L TL L + F+ E WLQ+YGYLPP D R RS +++ +A+AAMQ+FYG+
Sbjct: 15 LLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGL 74
Query: 83 NMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPK 142
+TGK D +T+ M++PRCGVPD+ K ++RRKRYA+ G KWQH IT+ I+N TPK
Sbjct: 75 QVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPK 134
Query: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENG-KRDVDITIIFASGFHGDSSPFDG 201
VG+ T +AIR+AF VW++ TPL F EVPY+ + G ++ DI I FA GFHGDS+PFDG
Sbjct: 135 VGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDG 194
Query: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPT 261
EGGFLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHS+DP+
Sbjct: 195 EGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPS 254
Query: 262 AIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKND 321
AIMAPFYQ+M+T+NF LP+DD +GIQ++YG P P PR
Sbjct: 255 AIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKM-------------PPQPRTTS 301
Query: 322 RPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQI 381
RP P +P P PNICDGNF+T+A+LR EMFVFK++WFWRVRNN+VMDGYPM I
Sbjct: 302 RPSVP----DKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPI 357
Query: 382 TYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSIIQDGWLYKYHWKWILEQRQSVP 437
FWRGLP SI+ YE DG FVFF KGD + + L + K I E + +P
Sbjct: 358 GQFWRGLPASINTAYERKDGKFVFF--KGDKHWVFDEASLEPGYPKHIKELGRGLP 411
>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
Length = 562
Score = 272 bits (695), Expect = 5e-73
Identities = 154/385 (40%), Positives = 218/385 (56%), Gaps = 36/385 (9%)
Query: 46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
WL +YGYLPP P + L+S E ++ A+ MQ+F G+ TG++D T+ M+KPRC +PD
Sbjct: 35 WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPD 94
Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163
G + RR+RYAL+G W+ + +T+ +++ + ++ R + A W +
Sbjct: 95 -VLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMES 153
Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGDTHF 222
LTF EV + ++ DI I FA FH DS PFDG GG LAHA+FPG I GDTHF
Sbjct: 154 GLTFHEVDSPQ----GQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHF 209
Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQ--YMETDNFKLPN 280
D +E WT G+ + +G DLF VAVHE GHALGL HS+ P +IM PFYQ + D ++L
Sbjct: 210 DDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQ 269
Query: 281 DDLQGIQKIYGPPDKIP--PPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGA 338
DD G+Q++YG + P PTR P PP P+PP PT PS+P
Sbjct: 270 DDRDGLQQLYGKAPQTPYDKPTRK-PLAPP--------------PQPPASPTHSPSFP-- 312
Query: 339 KPNICDGNFNTLAILRREMFVFKDQWFWRVR-NNRVMDGYPMQITYFWRGLPPSIDAVY- 396
P+ C+GNF+ +A +R E F FK WFWR++ + +++ P ++ FW GLP + V
Sbjct: 313 IPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQA 372
Query: 397 ---ENSDGNFVFFKVKGDTLSIIQD 418
+ DG + F G + QD
Sbjct: 373 AYARHRDGRILLF--SGPQFWVFQD 395
Score = 31.2 bits (69), Expect = 2.0
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 358 FVFKDQWFWRVRNN--RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
++ + + +WR R GYP ++ W G PPS D V ++ G+ FFK
Sbjct: 429 YLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTVSNAGDTYFFK 479
>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
Length = 467
Score = 244 bits (623), Expect = 1e-64
Identities = 139/365 (38%), Positives = 191/365 (52%), Gaps = 57/365 (15%)
Query: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
V+ +L+K+ LP + + + L MQ+F+G+N+TGK + T+D MKKPRCG
Sbjct: 33 VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92
Query: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
VPD + LT KW+ ++TY I+N TP++ + E +AI+ AF++W
Sbjct: 93 VPDSGG-----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWS 141
Query: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
+PL F + E DI I F HGD+SPFDG G LAHA+ PG GIGGD
Sbjct: 142 VASPLIFTRISQGE-------ADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDA 194
Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
HFD++E WT + N++ LFLVA HE GH+LGL HS+DP A+M P Y + ET N+ LP
Sbjct: 195 HFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQ 251
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
DD+ GIQ IYG S P P PKP P
Sbjct: 252 DDIDGIQAIYG------------------LSSNPIQPTGPSTPKPCDPSL---------- 283
Query: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
F+ + LR E+ FKD++FWR R+ ++ I+ FW LP I A YE+ D
Sbjct: 284 -----TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFD 337
Query: 401 GNFVF 405
+ +F
Sbjct: 338 RDLIF 342
Score = 32.3 bits (72), Expect = 0.92
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 354 RREMFVFKDQWFWRVRNNR--VMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF 405
R + + F + FWR N R + GYP I+ + G+ +DAV++ VF
Sbjct: 384 RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVF 437
>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
sapiens]
Length = 603
Score = 241 bits (616), Expect = 8e-64
Identities = 146/385 (37%), Positives = 200/385 (51%), Gaps = 41/385 (10%)
Query: 46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
WL ++GYLPP DP L++ E + A+ AMQQF G+ TG +D T+ MK PRC +PD
Sbjct: 55 WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114
Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163
RR+R A KW +++++ ++ +G R + A VW ++
Sbjct: 115 L---PVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171
Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPG-PGIGGDTHF 222
PL F EV S DI I F+ H D PFDG GG +AHA+FPG GDTHF
Sbjct: 172 PLNFHEVAGSA-------ADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHF 224
Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETD--NFKLPN 280
D DE WT + + G DLF VAVHE GHA+GL H +IM P+YQ D + LP
Sbjct: 225 DDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPY 284
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAK- 339
+D + ++YG + + P +P + P P PP R S P K
Sbjct: 285 EDKVRVWQLYGVRESVSPTAQP-----------------EEPPLLPEPPDNRSSAPPRKD 327
Query: 340 -PNICDGNFNTLAILRREMFVFKDQWFWRV-RNNRVMDGYPMQITYFWRGLP---PSIDA 394
P+ C +F+ +A +R E F FK ++FWR+ R+ ++ P Q+ FWRGLP S+DA
Sbjct: 328 VPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387
Query: 395 VYE-NSDGNFVFFKVKGDTLSIIQD 418
VYE SD VFF KGD + +D
Sbjct: 388 VYERTSDHKIVFF--KGDRYWVFKD 410
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/52 (44%), Positives = 32/52 (61%), Gaps = 3/52 (5%)
Query: 358 FVFKDQWFWRVRNN-RVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
+ FKDQ +WR ++ R MD GYP Q + WRG+P ++D SDG FF+
Sbjct: 444 YFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFR 494
>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
Length = 471
Score = 239 bits (611), Expect = 3e-63
Identities = 144/364 (39%), Positives = 189/364 (51%), Gaps = 58/364 (15%)
Query: 44 EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103
E +L+ Y Y P + +A +M L MQ F+G+ +TGK+D NT+D MKKPRCGV
Sbjct: 40 ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98
Query: 104 PDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163
PD ++++ + KW ++TY I N TP + E KA ++AF VW +VT
Sbjct: 99 PDV----GEYNVFPRTL-----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149
Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223
PL F + L +G DI I F HGD PFDG G LAHA+ PGP GGD HFD
Sbjct: 150 PLNF-----TRLHDGI--ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202
Query: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283
DE WT + G +LFLVA HE GH+LGL+HS DP A+M P Y Y +F LP+DD+
Sbjct: 203 DDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV 259
Query: 284 QGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNIC 343
QGIQ +YGP D+ P P P P+ C
Sbjct: 260 QGIQSLYGPGDEDPNPKHP-----------------------------------KTPDKC 284
Query: 344 DGNFNTLAI--LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDG 401
D + + AI LR E +FKD++FWR+ +V D FW LP IDA YE+
Sbjct: 285 DPSLSLDAITSLRGETMIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSH 343
Query: 402 NFVF 405
+ +F
Sbjct: 344 DLIF 347
>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
sapiens]
Length = 470
Score = 234 bits (598), Expect = 9e-62
Identities = 139/365 (38%), Positives = 194/365 (53%), Gaps = 56/365 (15%)
Query: 44 EVWLQK-YGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
E +L+K YG P + S M+ + MQ F G+ +TG++D +T++ M PRCG
Sbjct: 34 ERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCG 93
Query: 103 VPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNV 162
VPD + R G W+ +ITY I N TP + + AIR+AF VW NV
Sbjct: 94 VPD---------VHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNV 144
Query: 163 TPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHF 222
TPL F S++ G DI ++FA G HGD FDG+GG LAHA+ PG GIGGD HF
Sbjct: 145 TPLKF-----SKINTGM--ADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHF 197
Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDD 282
D DE WT + G +LFL AVHE+GH+LGL HS+DP A+M P Y+Y++ + F+L DD
Sbjct: 198 DEDEFWTT---HSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADD 254
Query: 283 LQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNI 342
++GIQ +YG DP++N R P+ ++P +
Sbjct: 255 IRGIQSLYG------------------------DPKENQR---------LPNPDNSEPAL 281
Query: 343 CDGN--FNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
CD N F+ + + ++F FKD++FW + R + I+ W LP I+A YE
Sbjct: 282 CDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL-ISSLWPTLPSGIEAAYEIEA 340
Query: 401 GNFVF 405
N VF
Sbjct: 341 RNQVF 345
>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
Length = 477
Score = 234 bits (597), Expect = 1e-61
Identities = 159/444 (35%), Positives = 220/444 (49%), Gaps = 68/444 (15%)
Query: 26 LLWILCATVC----------GTEQYFN-VEVWLQKYGYLPPTDPRMSVLRSAETMQSALA 74
+L +LC VC G + N V+ +L+ Y L + + + + +
Sbjct: 6 ILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIR 65
Query: 75 AMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTG-QKWQHKHIT 133
MQ+F G+ +TGK+D +T++ M+KPRCGVPD H R G KW+ H+T
Sbjct: 66 EMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG------HFR----TFPGIPKWRKTHLT 115
Query: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193
Y I N TP + A+ +A VW+ VTPLTF S L G + DI I FA H
Sbjct: 116 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVREH 168
Query: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
GD PFDG G LAHAY PGPGI GD HFD DE WT + G +LFLVA HE+GH+LG
Sbjct: 169 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLG 225
Query: 254 LEHSNDPTAIMAPFYQYM-ETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSI 312
L HS + A+M P Y + + F+L DD+ GIQ +YGP PP + P VP
Sbjct: 226 LFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGP----PPDSPETPLVP----- 276
Query: 313 PPADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRN 370
P PP P T P CD +F+ ++ LR E+ +FKD+ FWR ++
Sbjct: 277 --------TEPVPPEPGT---------PANCDPALSFDAVSTLRGEILIFKDRHFWR-KS 318
Query: 371 NRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTL-----SIIQDGWLYKYH 425
R ++ I+ FW LP +DA YE + + VF KG+ + ++ G+ H
Sbjct: 319 LRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFI-FKGNQFWAIRGNEVRAGYPRGIH 377
Query: 426 WKWILEQRQSVPVLSRQTEKHKTY 449
+ + EK+KTY
Sbjct: 378 TLGFPPTVRKIDAAISDKEKNKTY 401
>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
sapiens]
Length = 483
Score = 226 bits (576), Expect = 3e-59
Identities = 134/351 (38%), Positives = 185/351 (52%), Gaps = 53/351 (15%)
Query: 62 VLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYA 121
V R + +M + +Q F+G+ +TGK+D+ T++ +KKPRCGVPD + R
Sbjct: 61 VARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPD---------VANYRLF 111
Query: 122 LTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRD 181
KW+ +TY I TP + E KA+ A W + PL+F + E
Sbjct: 112 PGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGE------- 164
Query: 182 VDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLF 241
DI I F +G HGDS PFDG G LAHA+ PG G+GGDTHFD+ E WT+G +G +LF
Sbjct: 165 ADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT---NGFNLF 221
Query: 242 LVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
VA HE GHALGL HS DP+A+M P Y+Y F LP DD++GIQ +YG
Sbjct: 222 TVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYG---------- 271
Query: 302 PLPTVPPHRSIPPADPRKNDRPKP--PRPPTGRPSYPGAKPNICD--GNFNTLAILRREM 357
PRK KP P P +PS P++CD +F+ + +L +E+
Sbjct: 272 ---------------PRKVFLGKPTLPHAPHHKPSI----PDLCDSSSSFDAVTMLGKEL 312
Query: 358 FVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD-GNFVFFK 407
+FKD+ FWR + + P IT + L ++DA YE ++ G FFK
Sbjct: 313 LLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFK 363
>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
Length = 476
Score = 220 bits (560), Expect = 2e-57
Identities = 158/442 (35%), Positives = 215/442 (48%), Gaps = 67/442 (15%)
Query: 27 LWILCATVCGT--------EQYFNVEV---WLQKYGYLPPTDPRMSVLRSAETMQSALAA 75
L +LC VC E+ N ++ +L+KY Y D + + + + +
Sbjct: 7 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65
Query: 76 MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQ-KWQHKHITY 134
MQ+F G+ +TGK+D +T++ M+KPRCGVPD SS G KW+ H+TY
Sbjct: 66 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSS----------FPGMPKWRKTHLTY 115
Query: 135 SIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHG 194
I N TP + AI +A VW+ VTPLTF S L G + DI I FA HG
Sbjct: 116 RIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVKEHG 168
Query: 195 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGL 254
D FDG G LAHAY PGPG+ GD HFD DE WT + G +LFLVA HELGH+LGL
Sbjct: 169 DFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGL 225
Query: 255 EHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313
HS + A+M P Y + E F+L DD+ GIQ +YGP PP + P VP +S+P
Sbjct: 226 FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGP----PPASTEEPLVPT-KSVP 280
Query: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371
P CD +F+ ++ LR E FKD++FWR R++
Sbjct: 281 SG---------------------SEMPAKCDPALSFDAISTLRGEYLFFKDRYFWR-RSH 318
Query: 372 RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSI----IQDGWLYKYHWK 427
+ I+ FW LP +DA YE + + VF + +I +Q G+ H
Sbjct: 319 WNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTL 378
Query: 428 WILEQRQSVPVLSRQTEKHKTY 449
+ + EK KTY
Sbjct: 379 GFPPTIRKIDAAVSDKEKKKTY 400
>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
sapiens]
Length = 488
Score = 214 bits (545), Expect = 1e-55
Identities = 118/312 (37%), Positives = 169/312 (54%), Gaps = 28/312 (8%)
Query: 96 MKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRA 155
++ PRCGVPD + G S + R+KR+ L+G +W+ +TY I ++ + R+ + A
Sbjct: 75 LRPPRCGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133
Query: 156 FDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG 215
VW +VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP
Sbjct: 134 LKVWSDVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTH 186
Query: 216 IGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDN 275
GD HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY +
Sbjct: 187 REGDVHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP-- 242
Query: 276 FKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335
L DD +G+Q +YG P P T P + P I + P
Sbjct: 243 LSLSPDDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLE 286
Query: 336 PGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAV 395
P A P+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA
Sbjct: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346
Query: 396 YENSDGNFVFFK 407
+E++ G+ FF+
Sbjct: 347 FEDAQGHIWFFQ 358
Score = 35.4 bits (80), Expect = 0.11
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 16/88 (18%)
Query: 335 YPGAKPNICDGNFNTLAILR-------------REMFVFKDQWFWRVR--NNRVMDGYPM 379
Y G KP + L ++R +++ F+ + +WR RV P
Sbjct: 365 YDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPR 424
Query: 380 QITYFWRGLPPSIDAVYENSDGNFVFFK 407
+ T WRG+P IDA ++++DG F +
Sbjct: 425 RATD-WRGVPSEIDAAFQDADGYAYFLR 451
>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
sapiens]
Length = 469
Score = 212 bits (540), Expect = 5e-55
Identities = 137/371 (36%), Positives = 189/371 (50%), Gaps = 66/371 (17%)
Query: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
V+ +L+KY L ++ R++ + L MQ+F+G+ +TGK D T+ MK+PRCG
Sbjct: 34 VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93
Query: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
VPD + + LT +W+ H+TY I+N TP + + AI +AF +W
Sbjct: 94 VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142
Query: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
NVTPLTF +V + DI I F G H D+SPFDG GG LAHA+ PGPGIGGD
Sbjct: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195
Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
HFD DE WT N +L VA HELGH+LGL HS D A+M P Y + + + +L
Sbjct: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
DD+ GIQ IYG R + +P P T P
Sbjct: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275
Query: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397
CD F+ + +R E+ FKD+++ +R N + I+ FW LP ++A YE
Sbjct: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333
Query: 398 NSDGNFV-FFK 407
+D + V FFK
Sbjct: 334 FADRDEVRFFK 344
Score = 29.3 bits (64), Expect = 7.8
Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 358 FVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
+ F +WR R MD GYP I + + G+ +DAV+ DG F FF
Sbjct: 390 YFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFF 439
>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
Length = 403
Score = 205 bits (522), Expect = 6e-53
Identities = 130/338 (38%), Positives = 174/338 (51%), Gaps = 66/338 (19%)
Query: 76 MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT--GQKWQHKHIT 133
MQ+F+G+ +TGK D T+ MK+PRCGVPD + + LT +W+ H+T
Sbjct: 1 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ-----------FVLTEGNPRWEQTHLT 49
Query: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193
Y I+N TP + + AI +AF +W NVTPLTF +V + DI I F G H
Sbjct: 50 YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQ-------ADIMISFVRGDH 102
Query: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
D+SPFDG GG LAHA+ PGPGIGGD HFD DE WT N +L VA HELGH+LG
Sbjct: 103 RDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLG 159
Query: 254 LEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313
L HS D A+M P Y + + + +L DD+ GIQ IYG
Sbjct: 160 LSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG---------------------- 195
Query: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371
R + +P P T P CD F+ + +R E+ FKD+++ +R N
Sbjct: 196 ----RSQNPVQPIGPQT---------PKACDSKLTFDAITTIRGEVMFFKDRFY--MRTN 240
Query: 372 RVMDGYPMQ-ITYFWRGLPPSIDAVYENSDGNFV-FFK 407
+ I+ FW LP ++A YE +D + V FFK
Sbjct: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFK 278
Score = 29.3 bits (64), Expect = 7.8
Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 358 FVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
+ F +WR R MD GYP I + + G+ +DAV+ DG F FF
Sbjct: 324 YFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFF 373
>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
Length = 513
Score = 204 bits (519), Expect = 1e-52
Identities = 127/347 (36%), Positives = 169/347 (48%), Gaps = 59/347 (17%)
Query: 64 RSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT 123
++ + + MQ F+G+ +TGK+D NT++ MK PRCGVPD + + Y L
Sbjct: 54 KNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPD---------VGQYGYTLP 104
Query: 124 GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVD 183
G W+ ++TY I N TP + +AI+ +VW VTPL F ++ K D
Sbjct: 105 G--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIAD 155
Query: 184 ITIIFASGFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
I I F + HG FDG G L HA+ PGPG+GGDTHFD DE WT G +LFL
Sbjct: 156 IMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFL 212
Query: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
VA HE GHALGL HSND TA+M P Y ++ + L DD+ GIQ IYG K
Sbjct: 213 VAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPK------- 265
Query: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGN--FNTLAILRREMFVF 360
P P+ PT P+ CD + F+ + RRE+ F
Sbjct: 266 -------------------EPAKPKEPT--------IPHACDPDLTFDAITTFRREVMFF 298
Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
K + WR+ + + D I FW LP + A YEN + FK
Sbjct: 299 KGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFK 344
>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
[Homo sapiens]
Length = 520
Score = 193 bits (491), Expect = 2e-49
Identities = 137/408 (33%), Positives = 198/408 (48%), Gaps = 53/408 (12%)
Query: 23 LQTLLW----ILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQ 78
LQ LLW A G E E +L+KYGYL P+ ++ A+ A Q
Sbjct: 12 LQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAP---TSTRFSDAIRAFQW 68
Query: 79 FYGINMTGKVDRNTIDWMKKPRCGVPDQT--------------RGSSKFHIRRKRYALTG 124
+ ++G +DR T+ M +PRCGV D R +K R+KR+A G
Sbjct: 69 VSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMR-RKKRFAKQG 127
Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
KW +H++Y + N + +P R A+R AF +W NV+ L F E P DI
Sbjct: 128 NKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADI 181
Query: 185 TIIFASGFHGD--SSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
+ F G H D + FDG GG LAHA+ P G+ HFD DE W+L G +LF+
Sbjct: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLS--RRRGRNLFV 236
Query: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
V HE+GH LGL HS P A+MAP+Y+ + D L DD+ +Q +YG P
Sbjct: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYG-----KPLGGS 290
Query: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILR-REMFVFK 361
+ P + + + P+ RP T P Y C +F+ + + R +++++FK
Sbjct: 291 VAVQLPGKLFTDFETWDSYSPQGRRPETQGPKY-------CHSSFDAITVDRQQQLYIFK 343
Query: 362 DQWFWRV-RNNRVMDGYPMQITYFWRGLPPSIDAVYEN-SDGNFVFFK 407
FW V + V + P+Q W GLPP+I+A + +DG+F FFK
Sbjct: 344 GSHFWEVAADGNVSEPRPLQER--WVGLPPNIEAAAVSLNDGDFYFFK 389
>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
Length = 267
Score = 180 bits (457), Expect = 2e-45
Identities = 100/248 (40%), Positives = 137/248 (55%), Gaps = 22/248 (8%)
Query: 46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
W Q YL S ++A ++++ L MQ+F+G+ +TG ++ I+ M+KPRCGVPD
Sbjct: 32 WEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPD 91
Query: 106 QTRGSSKFHIRRKRYAL--TGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163
Y+L KW K +TY I + T + + + +A ++W
Sbjct: 92 VAE-----------YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEI 140
Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223
PL F +V + DI I FA G HGDS PFDG G LAHA+ PG G+GGD HFD
Sbjct: 141 PLHFRKVVWGT-------ADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFD 193
Query: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283
DE WT G+ G + A HELGH+LG+ HS+DP A+M P Y + NFKL DD+
Sbjct: 194 EDERWTDGSSL--GINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDI 251
Query: 284 QGIQKIYG 291
+GIQK+YG
Sbjct: 252 KGIQKLYG 259
>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
[Homo sapiens]
Length = 508
Score = 164 bits (415), Expect = 2e-40
Identities = 122/372 (32%), Positives = 183/372 (49%), Gaps = 53/372 (14%)
Query: 46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
+L +YGYL + + E + AL A Q+ + ++G++D T M++PRCG+ D
Sbjct: 31 YLSQYGYLQKPLEGSNNFKP-EDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89
Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPL 165
F+ + +Y L G +W+ KH+T+ I N+ + R A+R+AF W NV PL
Sbjct: 90 P------FNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPL 142
Query: 166 TFEEVPYSELENGKRDVDITIIFASGFHGD-----SSPFDGEGGFLAHAYFPGPGIGGDT 220
TF+EV + G D+ ++ FHG S+ FDG G LAHA P G
Sbjct: 143 TFQEV-----QAGAADIRLS------FHGRQSSYCSNTFDGPGRVLAHADIPEL---GSV 188
Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
HFD DE WT G + G +L ++A HE+GHALGL HS A+MAP Y+ +FKL
Sbjct: 189 HFDEDEFWTEG--TYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYR-PHFKLHP 245
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
DD+ GIQ +YG K P R D + + P PP P+ P P
Sbjct: 246 DDVAGIQALYG---KKSPVIR--------------DEEEEETELPTVPPV--PTEPSPMP 286
Query: 341 NICDGNFNTLAI-LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENS 399
+ C + + + R + + FK + W V ++ G +++ W GLP ++DA +
Sbjct: 287 DPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLPGNLDAAVYSP 344
Query: 400 DGNFVFFKVKGD 411
++ F KGD
Sbjct: 345 RTQWIHF-FKGD 355
Score = 30.4 bits (67), Expect = 3.5
Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 2/59 (3%)
Query: 353 LRREMFVFKDQ--WFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVK 409
L +++F+FK W W YP I + G+P A DG FFK K
Sbjct: 388 LNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGK 446
>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
sapiens]
Length = 261
Score = 142 bits (359), Expect = 5e-34
Identities = 86/224 (38%), Positives = 117/224 (52%), Gaps = 20/224 (8%)
Query: 68 TMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKW 127
T ++ +QQF+ N T +D + +P CGVPD S I R KW
Sbjct: 50 TQETQTQLLQQFHR-NGTDLLDMQMHALLHQPHCGVPD----GSDTSISPGRC-----KW 99
Query: 128 QHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
+TY I N + + +I A +W NVTPL F++V +NG D DI +
Sbjct: 100 NKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQV-----QNG--DADIKVS 152
Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHE 247
F H D PFDG GG L HA+ P G G HFD +E W+ + G +LFLVA HE
Sbjct: 153 FWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDT---GYNLFLVATHE 209
Query: 248 LGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291
+GH+LGL+HS + ++IM P Y Y + F+L DD+Q IQ +YG
Sbjct: 210 IGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253
>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
Length = 610
Score = 137 bits (344), Expect = 3e-32
Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)
Query: 69 MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128
++ L MQ+F+G+ TG +D+NTI+ M+KPRCG PD + F R+ KW
Sbjct: 20 LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 70
Query: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
ITY I TP + DPET A RAF VW +VTPL F S + +G + DI I
Sbjct: 71 KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 122
Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231
F HGD PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 123 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 166
Score = 116 bits (291), Expect = 4e-26
Identities = 71/179 (39%), Positives = 89/179 (49%), Gaps = 35/179 (19%)
Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
++D D W G G LFLVA HE GHA+GLEHS DP A+MAP Y Y T NF+L
Sbjct: 330 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 385
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
DD++GIQ++YG I T P PT+ P P
Sbjct: 386 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 416
Query: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYE 397
IC D F+ +A +R E+F FKD++ WR R P+ + FW LP IDAVYE
Sbjct: 417 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 475
Score = 33.1 bits (74), Expect = 0.54
Identities = 16/54 (29%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 355 REMFVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
++ ++F FWR + MD G+P I W +P ++DAV + G +F
Sbjct: 528 KKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYF 581
>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
[Homo sapiens]
Length = 660
Score = 137 bits (344), Expect = 3e-32
Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)
Query: 69 MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128
++ L MQ+F+G+ TG +D+NTI+ M+KPRCG PD + F R+ KW
Sbjct: 70 LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 120
Query: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
ITY I TP + DPET A RAF VW +VTPL F S + +G + DI I
Sbjct: 121 KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 172
Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231
F HGD PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216
Score = 116 bits (291), Expect = 4e-26
Identities = 71/179 (39%), Positives = 89/179 (49%), Gaps = 35/179 (19%)
Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
++D D W G G LFLVA HE GHA+GLEHS DP A+MAP Y Y T NF+L
Sbjct: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
DD++GIQ++YG I T P PT+ P P
Sbjct: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 466
Query: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYE 397
IC D F+ +A +R E+F FKD++ WR R P+ + FW LP IDAVYE
Sbjct: 467 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 525
Score = 33.1 bits (74), Expect = 0.54
Identities = 16/54 (29%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 355 REMFVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
++ ++F FWR + MD G+P I W +P ++DAV + G +F
Sbjct: 578 KKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYF 631
>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
Length = 707
Score = 129 bits (323), Expect = 7e-30
Identities = 81/200 (40%), Positives = 104/200 (52%), Gaps = 26/200 (13%)
Query: 44 EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103
E +L +YGY + R ++++ AL +Q+ + TG++D T+ M+ PRCGV
Sbjct: 46 EEYLYRYGYTRVAEMR----GESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGV 101
Query: 104 PDQTRGSSKFHIRRKRYALTGQ-KWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNV 162
PD R + G KW H +ITY I+N + + A RAF +W V
Sbjct: 102 PDLGRFQT----------FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAV 151
Query: 163 TPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHF 222
TPLTF V YS RD DI I F HGD PFDG+ G LAHA+ PGPGI GD HF
Sbjct: 152 TPLTFTRV-YS------RDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHF 204
Query: 223 DSDEPWTLGN----PNHDGN 238
D DE W+LG P GN
Sbjct: 205 DDDELWSLGKGVVVPTRFGN 224
Score = 109 bits (273), Expect = 5e-24
Identities = 76/210 (36%), Positives = 105/210 (50%), Gaps = 28/210 (13%)
Query: 220 THFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLP 279
++FDSD+ W G G LFLVA HE GHALGL+HS+ P A+M P Y++ T+ L
Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLH 432
Query: 280 NDDLQGIQKIYGP---PDKIPP-PTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335
DD+ GI+ +YGP P+ PP T P PT PP P P + +P PTG PS
Sbjct: 433 KDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPP-TVCPTGPPTVHPSERPTAGPTGPPSA 491
Query: 336 -----PGAKP------------NICDGN-FNTLAILRREMFVFKDQWFWRVRNNR-VMDG 376
P A P + C+ N F+ +A + ++++FKD +WR R
Sbjct: 492 GPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQ 551
Query: 377 YPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
P I W LP +D+V+E +FF
Sbjct: 552 GPFLIADKWPALPRKLDSVFEERLSKKLFF 581
>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
sapiens]
Length = 569
Score = 102 bits (254), Expect = 7e-22
Identities = 106/390 (27%), Positives = 156/390 (40%), Gaps = 118/390 (30%)
Query: 54 PPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT------ 107
PP P+ + L A + Q+ + +G++D T+ M +PRCGVPD
Sbjct: 76 PPETPKGAALAEA------VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSA 129
Query: 108 ---------RGSSKFHIRRKRYALTGQKWQ--------------HKHITYSI--KNVTPK 142
R S+ R +L+ + WQ + +++ + + ++ +
Sbjct: 130 PPSPPGPPPRARSR-RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQ 188
Query: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH-GDSSPFDG 201
+ + R+ + AF +W VTPL F E +L VDI + F G H G FDG
Sbjct: 189 LSVADQRRIVALAFRMWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDG 244
Query: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHD-GNDLFLVAVHELGHALGLEHSNDP 260
G AHA+ G D HFD DE +T P D G L VAVHE+GH LGL H+
Sbjct: 245 SGQEFAHAWRLG-----DIHFDDDEHFT--PPTSDTGISLLKVAVHEIGHVLGLPHTYRT 297
Query: 261 TAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKN 320
+IM P Y E F+L D + IQK+YG
Sbjct: 298 GSIMQPNYIPQE-PAFELDWSDRKAIQKLYGS---------------------------- 328
Query: 321 DRPKPPRPPTGRPSYPGAKPNICDGNFNTL-------------AILRREMFVFKDQWFW- 366
C+G+F+T ++R + F++ W+W
Sbjct: 329 ----------------------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWL 366
Query: 367 -RVRNNRVMDGYPMQITYFWRGLPP-SIDA 394
RNNR G P+QI W G+P +IDA
Sbjct: 367 YENRNNRTRYGDPIQILTGWPGIPTHNIDA 396
>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
Length = 390
Score = 101 bits (251), Expect = 2e-21
Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 22/194 (11%)
Query: 116 RRKRYALTGQK--WQHKHITYSIKNVTPKVGDP-ETRKAIRRAFDVWQNVTPLTFEEVPY 172
RR+RY LT + W H ++TY I + + P ETR+A+ AF +W +V+P +F EV
Sbjct: 75 RRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAP 134
Query: 173 ---SELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
S+L G ++ T S H FDG G LAHA+FP G HFD E W
Sbjct: 135 EQPSDLRIGFYPINHTDCLVSALH---HCFDGPTGELAHAFFPPHG---GIHFDDSEYWV 188
Query: 230 LGNPNHDGN------DLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK-LPNDD 282
LG + DL VA HE+GHALGL HS A+M + +K L D+
Sbjct: 189 LGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALM---HLNATLRGWKALSQDE 245
Query: 283 LQGIQKIYGPPDKI 296
L G+ ++YG D++
Sbjct: 246 LWGLHRLYGCLDRL 259
>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 78.6 bits (192), Expect = 1e-14
Identities = 43/105 (40%), Positives = 59/105 (56%), Gaps = 12/105 (11%)
Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
QKWQ +N P + + +A +AF++W N + LTF SE D+ +
Sbjct: 21 QKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESE-----GDIIL 69
Query: 185 TIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
+ +F + H D+SPF G G LAHA+ PGPGIGGD HFD+DE T
Sbjct: 70 SFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113
>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
sapiens]
Length = 183
Score = 76.3 bits (186), Expect = 6e-14
Identities = 53/163 (32%), Positives = 84/163 (51%), Gaps = 24/163 (14%)
Query: 46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
+L +YGYL + + E + AL A Q+ + ++G++D T M++PRCG+ D
Sbjct: 31 YLSQYGYLQKPLEGSNNFKP-EDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89
Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPL 165
F+ + +Y L G +W+ KH+T+ I N+ + R A+R+AF W NV PL
Sbjct: 90 P------FNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPL 142
Query: 166 TFEEVPYSELENGKRDVDITIIFASGFHGD-----SSPFDGEG 203
TF+EV + G D+ ++ FHG S+ FDG G
Sbjct: 143 TFQEV-----QAGAADIRLS------FHGRQSSYCSNTFDGPG 174
>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 76.3 bits (186), Expect = 6e-14
Identities = 42/105 (40%), Positives = 58/105 (55%), Gaps = 12/105 (11%)
Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
QKWQ +N P + + +A +AF++W + LTF SE D+ +
Sbjct: 21 QKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESE-----GDIIL 69
Query: 185 TIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
+ +F + H D+SPF G G LAHA+ PGPGIGGD HFD+DE T
Sbjct: 70 SFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113
>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 358
Score = 75.5 bits (184), Expect = 9e-14
Identities = 39/93 (41%), Positives = 55/93 (59%), Gaps = 6/93 (6%)
Query: 137 KNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDS 196
+N P + + +A +AF++W N + LTF SE D+ ++ +F + H D+
Sbjct: 187 QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESE-----GDIILSFVFLADLH-DN 240
Query: 197 SPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
SPF G G LAHA+ PGPGIGGD HFD+DE T
Sbjct: 241 SPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.454
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,766,615
Number of Sequences: 37866
Number of extensions: 1245957
Number of successful extensions: 11789
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 311
Number of HSP's that attempted gapping in prelim test: 7596
Number of HSP's gapped (non-prelim): 3146
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.