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Search of human proteins with 149192855
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149192855 HLA-B associated transcript 2-like [Homo sapiens]
(2229 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149192855 HLA-B associated transcript 2-like [Homo sapiens] 4523 0.0
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 710 0.0
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 362 2e-99
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 72 8e-12
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 63 4e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 59 4e-08
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 59 7e-08
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 59 7e-08
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 59 7e-08
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 57 2e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 54 1e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 54 1e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 54 1e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 54 1e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 54 1e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 54 1e-06
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 54 2e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 54 2e-06
gi|221139764 PHD and ring finger domains 1 [Homo sapiens] 54 2e-06
gi|163965366 nascent polypeptide-associated complex alpha subuni... 54 2e-06
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 53 4e-06
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 52 9e-06
gi|27262647 ataxin 2 related protein isoform A [Homo sapiens] 51 1e-05
gi|27262645 ataxin 2 related protein isoform B [Homo sapiens] 51 1e-05
gi|27262649 ataxin 2 related protein isoform C [Homo sapiens] 51 1e-05
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 50 2e-05
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 50 2e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 50 2e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 50 2e-05
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 50 2e-05
>gi|149192855 HLA-B associated transcript 2-like [Homo sapiens]
Length = 2229
Score = 4523 bits (11731), Expect = 0.0
Identities = 2229/2229 (100%), Positives = 2229/2229 (100%)
Query: 1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP 60
MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP
Sbjct: 1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP 60
Query: 61 ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS 120
ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS
Sbjct: 61 ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS 120
Query: 121 NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG 180
NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG
Sbjct: 121 NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG 180
Query: 181 QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG 240
QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG
Sbjct: 181 QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG 240
Query: 241 APSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVER 300
APSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVER
Sbjct: 241 APSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVER 300
Query: 301 GSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG 360
GSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG
Sbjct: 301 GSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG 360
Query: 361 LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSA 420
LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSA
Sbjct: 361 LDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSA 420
Query: 421 DSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQS 480
DSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQS
Sbjct: 421 DSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQS 480
Query: 481 IEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR 540
IEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR
Sbjct: 481 IEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAR 540
Query: 541 KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ 600
KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ
Sbjct: 541 KAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ 600
Query: 601 SNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTF 660
SNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTF
Sbjct: 601 SNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTF 660
Query: 661 YPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR 720
YPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR
Sbjct: 661 YPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCR 720
Query: 721 SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSF 780
SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSF
Sbjct: 721 SEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSF 780
Query: 781 SASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDA 840
SASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDA
Sbjct: 781 SASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDA 840
Query: 841 GAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNIS 900
GAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNIS
Sbjct: 841 GAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNIS 900
Query: 901 SWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELE 960
SWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELE
Sbjct: 901 SWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELE 960
Query: 961 KIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKF 1020
KIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKF
Sbjct: 961 KIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKF 1020
Query: 1021 EEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRP 1080
EEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRP
Sbjct: 1021 EEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRP 1080
Query: 1081 AGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSE 1140
AGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSE
Sbjct: 1081 AGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSE 1140
Query: 1141 YEELPKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRA 1200
YEELPKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRA
Sbjct: 1141 YEELPKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRA 1200
Query: 1201 FGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSY 1260
FGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSY
Sbjct: 1201 FGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSY 1260
Query: 1261 RHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQER 1320
RHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQER
Sbjct: 1261 RHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQER 1320
Query: 1321 ESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASES 1380
ESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASES
Sbjct: 1321 ESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASES 1380
Query: 1381 SDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGF 1440
SDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGF
Sbjct: 1381 SDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGF 1440
Query: 1441 GEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHAS 1500
GEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHAS
Sbjct: 1441 GEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHAS 1500
Query: 1501 ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGE 1560
ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGE
Sbjct: 1501 ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGE 1560
Query: 1561 GFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG 1620
GFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG
Sbjct: 1561 GFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG 1620
Query: 1621 SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESR 1680
SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESR
Sbjct: 1621 SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESR 1680
Query: 1681 ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPG 1740
ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPG
Sbjct: 1681 ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPG 1740
Query: 1741 PIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG 1800
PIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG
Sbjct: 1741 PIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG 1800
Query: 1801 SASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESAR 1860
SASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESAR
Sbjct: 1801 SASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESAR 1860
Query: 1861 KAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPG 1920
KAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPG
Sbjct: 1861 KAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPG 1920
Query: 1921 SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP 1980
SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP
Sbjct: 1921 SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP 1980
Query: 1981 VSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGS 2040
VSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGS
Sbjct: 1981 VSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGS 2040
Query: 2041 PYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPP 2100
PYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPP
Sbjct: 2041 PYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPP 2100
Query: 2101 GQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPS 2160
GQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPS
Sbjct: 2101 GQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPS 2160
Query: 2161 SASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAPSAASQMKRTGAIKPR 2220
SASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAPSAASQMKRTGAIKPR
Sbjct: 2161 SASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAPSAASQMKRTGAIKPR 2220
Query: 2221 AVKVEESKA 2229
AVKVEESKA
Sbjct: 2221 AVKVEESKA 2229
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 710 bits (1832), Expect = 0.0
Identities = 731/2296 (31%), Positives = 957/2296 (41%), Gaps = 491/2296 (21%)
Query: 1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP 60
MSDR G KGKDGK KYS+L+LFD YKGKS++ + +V PRHGLQSLGKVA ARRMPPP
Sbjct: 1 MSDRSGPTAKGKDGK-KYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPP 59
Query: 61 ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS 120
ANLPSLK+ENKGNDPN+ +VPKDGTGWA+KQ+Q DPKSS A+ +QPPES P P Q S
Sbjct: 60 ANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPAS 119
Query: 121 NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG 180
N Q + ENT VP G KSWAQ + H G R SS L FS EEFPTL+AAG
Sbjct: 120 N-QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGD 178
Query: 181 QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG 240
QDKA KE+ + S GPGPSLRPQN T+WR+GGGR P EL +S G
Sbjct: 179 QDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGR----------GPDELEGPDSKLHHG 228
Query: 241 APSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVER 300
DP +G Q G PP Y M+P FM P
Sbjct: 229 ----------HDP---------RGGLQPSGPPQFPP-YRGMMPPFMYPPYL--------- 259
Query: 301 GSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG 360
FP P P+ P+R + D + R+ R P +LVE RP+I+ +NLK
Sbjct: 260 -PFPPP---YGPQGPYR-YPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKE 314
Query: 361 LDDLDADADDGWAGLHEEVDYSEKLKFSDDEE----EEEVVKDGRPKWNSWDPRRQRQLS 416
D LD + DDGWAG HEEVDY+EKLKFSD+E+ +EE + R ++ R +
Sbjct: 315 FDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEAD 374
Query: 417 MSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLH-----GWAPGPDYQKSS 471
+S +++ + WAE P P+PP H W P DY
Sbjct: 375 GKKGNSPNSEPPTPK-TAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRG 433
Query: 472 MGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQ 531
G + + ED+++ R+K SE+S AVERAR+RREEEERR +EER AACA KLK+
Sbjct: 434 -GPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKR 492
Query: 532 LDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQE-----NGPAVHKGSPEF-------- 578
LD+K K +A A P +P+ A P+E P +PE
Sbjct: 493 LDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQA 552
Query: 579 -PAQETPTTFPEEAPTV-----SPAVAQSNSSEEEAREAGSPAQEF-------------- 618
PAQ TPT APT+ S + S S E E P++E
Sbjct: 553 PPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPP 612
Query: 619 -------------------------KYQKSLPPRFQRQQQQQ---QQEQLYKMQHWQ--- 647
KYQKSLPPRFQRQQQ+Q QQ+Q QH Q
Sbjct: 613 VPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSA 672
Query: 648 -PVYPPPSHPQ-----------------RTFYP----HHPQM--LGFDPRWMMMPSYMDP 683
P PPS PQ + YP P M + FDPRWMM+P Y+DP
Sbjct: 673 PPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDP 732
Query: 684 RITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSE--DQNCVPPLQERKVTPIDSP 741
R+ R P+DFYP +HPSGL +P+E + G SE D++ L+ER P+D
Sbjct: 733 RLLQGRPPLDFYPPGVHPSGL----VPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPK 788
Query: 742 PVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNES-------SFSASL-----GRAGG 789
W + + A ++ PL P D +R+E+ + AS A G
Sbjct: 789 LAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPG 848
Query: 790 VSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPP-QENVQDAGAPGGHTQ 848
R EE G + L +PP + V P
Sbjct: 849 PPISRFPLEEPGP------------------------RPLPWPPGSDEVAKIQTP----- 879
Query: 849 NLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSP 908
P +K+P + ETA P G + S + P
Sbjct: 880 ------------PPKKEPP--------KEETAQLTGPEAGRKPARG----VGSGGQGPPP 915
Query: 909 NKQPS-SEPEWTPEPRSS-SSQHPEQTGR-TRRSGPIKKPVLKALKVEDKEKELEKIKQE 965
++ S +E W P P SS PE+ G RR+GPIKKP K +EL E
Sbjct: 916 PRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKP-----PPPTKVEELPPKPLE 970
Query: 966 LGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK 1025
G+E+ + K T K L T
Sbjct: 971 QGDETPKPPKPDPLKITKGK---------LGGPKET------------------------ 997
Query: 1026 PDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARG----RGRGFREFTFRGRPA 1081
PP + P R ++ + + RG+ RG RGRGFR
Sbjct: 998 --------PPNGNLSPAPRLRRDYSY-ERVGPTSCRGRGRGEYFARGRGFR--------- 1039
Query: 1082 GGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEY 1141
G GG GARS S R RG R PR R ASET SEGSEY
Sbjct: 1040 -----GTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEY 1094
Query: 1142 EELPKRRRQRGSENGNEG-----SLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAK-- 1194
EE+PKRRRQRGSE G+E + ++E T K+G + S A+
Sbjct: 1095 EEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFT 1154
Query: 1195 SRGPRAFGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRD 1254
+RG R F P G GR + P W + + ++ S+ P
Sbjct: 1155 ARGGRVFTPRGVPSRRGRGGGRPP--PQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEK 1212
Query: 1255 YVPDSYRHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRR--RPPRQDKPPR 1312
+P G G + ED RP RRR R +QDKPPR
Sbjct: 1213 LIPGPLSPVARGGSNGGSNVGMED----------------GERPRRRRHGRAQQQDKPPR 1256
Query: 1313 FRRLRQERESLGLWGPEEEPHL-LAGQWPGRPKLCSGDKSGTVGRR----SPELSYQNSS 1367
FRRL+QERE+ G E +P L L PG + + RR SP+LS QN S
Sbjct: 1257 FRRLKQERENAAR-GSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQN-S 1314
Query: 1368 DHANEEWETASESSDF-SERRERREGPG---------SEPDSQVDG---GLSGASLGE-- 1412
D ANEEWETASESSDF SERR +E P P G G+S S G+
Sbjct: 1315 DQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLS 1374
Query: 1413 --KKELAKRSFSSQRPVVDRQSRKLEPGG-FGEKPVRPGGGDTSP-------RYESQQNG 1462
K+L+KRSFSSQRP ++RQ+R+ PGG G GGG P R + +
Sbjct: 1375 QRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWP 1434
Query: 1463 TPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHAS-ADLPEASSKKAEKEAKLAAPR 1521
+P R P+E PG S + + L++ H++ A + +A ++ + ++ + AP
Sbjct: 1435 SPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPG 1494
Query: 1522 A----------GEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMV---------GEGF 1562
QG + + Y + + SS E G MV G
Sbjct: 1495 GHPRHKPGLPQAPQGPSPRP-PTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGV 1553
Query: 1563 IEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPGSS 1622
K++ R + +E+++ P L S+ P Q E D +
Sbjct: 1554 SPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSK--PEGPGPQ----AESRDTGT--EA 1605
Query: 1623 LGTEIW---ESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAES 1679
L IW +++ + + + W + ++ F G + SQ DSGVDLS +S
Sbjct: 1606 LTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDV------AGTEMSQSDSGVDLSGDS 1659
Query: 1680 RESSATSSQRSSPYGTLK------PEEMSGPG-----LAEPKADSHKEQAPKPSEQKDSE 1728
+ SS SQRSSP G LK P+ G E S + P P+
Sbjct: 1660 QVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDR 1719
Query: 1729 QGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGV 1788
+ + + PGPIG ERS + +G+E G + P S P PP++FG
Sbjct: 1720 KELPREQPLPPGPIGTERSQRTDRGTE-----PGPIRP----------SHRPGPPVQFGT 1764
Query: 1789 SPKDSDFSLPPGSASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFP 1848
S KDSD L G + +K + L A +T++IP+ RD + P
Sbjct: 1765 SDKDSDLRLVVGDS--------LKAEKEL--TASVTEAIPV-SRDWEL----------LP 1803
Query: 1849 TADLTLKMESARKAWENSPSLPEQSSPG-----GAGSGIQPPSSVGASSGVNYSSF---- 1899
+A + + +S K ++ +PE SS G G PSS S G S
Sbjct: 1804 SAAASAEPQS--KNLDSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPNS 1861
Query: 1900 -----GGVSMPP-------MPVASVAPSASMPGSHLPPLYLD--------------GHV- 1932
G S+ P +P PSA + G L +LD G V
Sbjct: 1862 GGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVL 1921
Query: 1933 -----FASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLG-LRGGLPVSQ--- 1983
F P P +P Q T LQ Q G L G P Q
Sbjct: 1922 YPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLL 1981
Query: 1984 ----SQ---EIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAF-PGMQPLEMVK 2035
SQ F SL P P +PP +L G AL+PP A P P V
Sbjct: 1982 PMVDSQLPVVNFGSLPP-------APPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVL 2034
Query: 2036 PQSGSPYQPMSGNQAL 2051
P P+ G L
Sbjct: 2035 PSPARPFPASLGRAEL 2050
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 362 bits (930), Expect = 2e-99
Identities = 425/1450 (29%), Positives = 632/1450 (43%), Gaps = 232/1450 (16%)
Query: 407 WDPRRQRQLSMSSADSADAKRTREEGKDWAE---AVGASRVVRKAP-----DPQPPPRKL 458
W RR++Q +S+A KR EE + E A A ++ R + QP P ++
Sbjct: 445 WKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEI 504
Query: 459 HGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAR 518
+ ++ ++Q E + +K RQ+ + E+ + E+ R+ E+E ++ +
Sbjct: 505 REREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREM-EKERKQEK 563
Query: 519 EERLAACAAKLKQLDQKCKQARKAGEARKQAEKEV----PWSPSAEK-ASPQENGPAVHK 573
E+ L K K+L QK K+ K E K+ EK P P+ E QE+ + +K
Sbjct: 564 EKELERQKEKEKEL-QKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNK 622
Query: 574 GS-PEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQ 632
P F Q++ + E P V +S S A +G Q +QKSLPPRFQRQQ
Sbjct: 623 EEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQ---FQKSLPPRFQRQQ 679
Query: 633 QQQQQEQLYKMQHW---------QP----VYPPPSHPQRTFYPHHPQML---GFDPRWMM 676
+Q +Q+Q + Q QP V PPP P HPQ L GFDPRW+M
Sbjct: 680 EQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLM 739
Query: 677 MPSYMDPRITPTRTPVDFYPSALHPSGLM-KPMMPQESLNGTGCRSED-QNCVPPLQERK 734
M SYMDPR+ R +D P +HP + KP+M ++ + G+ SE ++ ++
Sbjct: 740 MQSYMDPRMMSGRPAMDIPP--IHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDHA 797
Query: 735 VTPIDSPPVWSPEGYMALQSKGYPLPHP-KSSDTLAMDMRVRNESSFSASLGRAGGVSA- 792
++ + +W + Y + + P + + + + + E +A + A
Sbjct: 798 ISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAH 857
Query: 793 -QRDLFEERGEEYLSAFDKKAQADF----------DSCISSQRIGQELLFPPQENVQDAG 841
+ D E E + F ++ D +C + Q+ L PQE A
Sbjct: 858 PKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAP--DQKTLSAPQEERISAV 915
Query: 842 APGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVER--ETPREGTAFNI 899
+ PDE++ E + D+ +ER E P++
Sbjct: 916 ESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRS 975
Query: 900 SSWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGR-TRRSGPIKKPVLKALKVED---K 955
S K P K S+ E PR SS++ E R RRSGPIKKPVL+ +K E K
Sbjct: 976 SEGPK---PEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRK 1032
Query: 956 EKELEK---------IKQELGEESTR---------------------LAKEKEQSPTAE- 984
EKE EK +K E E+ + E E+ P+ E
Sbjct: 1033 EKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTET 1092
Query: 985 ----KDEDEENDASLANSSTTTLEDKGPGHATFGRE---ATKFEEEEKPDKAW------- 1030
+ ++ + L ST +E P T ++ A +EE++P+K
Sbjct: 1093 ATLAQKPSQDTEKPLEPVSTVQVE---PAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIE 1149
Query: 1031 ----EARPP-RESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRPAGGNG 1085
++RP ++ S +PP R W E F +G RGRGRG E+ RGR G+
Sbjct: 1150 RPRPDSRPAVKKESTLPP--RTYWKEARERDWFPDQGY-RGRGRG--EYYSRGRSYRGSY 1204
Query: 1086 SGLCGGGVLGARSIYCSSQRSGRGRGLREFA----RPEDCPRAKPRRRVASETHSEGSEY 1141
G GG G R ++ R E P R+R SET SE S++
Sbjct: 1205 GGRGRGG-------------RGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDF 1251
Query: 1142 EELPKRRRQRGSENGNEGSLLER--EESTLKKGDC--RDSWRSNKGCSEDHSGLDAKSRG 1197
E +PKRRRQRGSE + + E ++ +L KG R+ NK + HS +
Sbjct: 1252 EVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNH- 1310
Query: 1198 PRAFGRALP-PRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYV 1256
R R L P + + + F+ K P + + G + G R P R
Sbjct: 1311 VRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGR---------GGTFRRGGRDPGGRPSR 1361
Query: 1257 PDSYRHP----DAFGGRGFEDSRAEDKRSFFQDEH----VADS---------ENAENRPF 1299
P + R P + + R E + ED + E AD + A RP
Sbjct: 1362 PSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERPR 1421
Query: 1300 RRR--RPPRQDKPPRFRRLRQERESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVG-- 1355
R+R RPPRQDKPPRFRRLR ERE+ + ++A G + + T+G
Sbjct: 1422 RQRPTRPPRQDKPPRFRRLR-EREAAS-----KSNEVVAVPTNGTVNNVAQEPVNTLGDI 1475
Query: 1356 --RRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEK 1413
++P+LS QNSSD ANEEWETASESSDF+ERRER E ++ ++Q + L K
Sbjct: 1476 SGNKTPDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPK 1535
Query: 1414 KELAKRSFSSQRPVVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKV-KRSPD 1472
+E+AKRSFSSQRP VDRQ+R+ G P + G + PR E +++G P K KR P
Sbjct: 1536 REIAKRSFSSQRP-VDRQNRRGNNG-----PPKSGRNFSGPRNE-RRSGPPSKSGKRGPF 1588
Query: 1473 EALPGGLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEA---KLAAPRAG-----E 1524
+ P G +G +G S AH +P + +K K++ K P+ G E
Sbjct: 1589 DDQPAGTTGVDLINGSS-------AHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKE 1641
Query: 1525 QGEAMKQFDL-NYGS-AIIENCGSSPGEESEVGSMVGEGFIEVLTKK-QRRLLEEERRKK 1581
+ +A+ QFDL NY S II++ E ++ +GF EV++KK Q+RL +EERRKK
Sbjct: 1642 KVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKK 1701
Query: 1582 -EQAVQV------PVKGRGLSSRIPPRFAKKQ-NNLCLEQGDVTVP-------GSSLGTE 1626
EQ +QV KGR +S++PPRFAKKQ + Q +VP S
Sbjct: 1702 EEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASAPLPPSTSAS 1761
Query: 1627 IWESSSQALP---------VQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSA 1677
+ S+S LP AP S V A +S ++ S+ + A
Sbjct: 1762 VPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVPASPLAPVSASASVSASVPA 1821
Query: 1678 ESRESSATSS 1687
+ ++ TSS
Sbjct: 1822 STSAAAITSS 1831
Score = 299 bits (765), Expect = 2e-80
Identities = 238/667 (35%), Positives = 323/667 (48%), Gaps = 101/667 (15%)
Query: 1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPP 60
MS++ GQ TK KDGK KY+TLSLF+ YKGKS++ +++ RHGLQSLGKV +RRMPPP
Sbjct: 1 MSEKSGQSTKAKDGK-KYATLSLFNTYKGKSLETQKTTA--RHGLQSLGKVGISRRMPPP 57
Query: 61 ANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVS 120
ANLPSLK+ENKGNDPN+ IVPKDGTGWA+KQ+Q + + + + P + P+PG+
Sbjct: 58 ANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKT----PEVPPAQPKPGVAA--- 110
Query: 121 NLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGG 180
V PKSWA + K G G++ +S+ +EFP+L+AAG
Sbjct: 111 -------------PPEVAPAPKSWA--SNKQGGQGDGIQVNSQF----QQEFPSLQAAGD 151
Query: 181 QDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDG 240
Q+K KEK D +YGPGPSLRP NV WR+ GG+ S +S G S+ G
Sbjct: 152 QEK--KEKETNDDNYGPGPSLRPPNVACWRD-GGKAAGSPSSSDQDEKLPGQDESTAGTS 208
Query: 241 APSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVER 300
+ K + P Q G + + Y M+P +M +
Sbjct: 209 EQNDILKVVEKRIACGPPQAKLNGQQAALAS-----QYRAMMPPYMFQ----------QY 253
Query: 301 GSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKG 360
P L R P E GL R P RP+I++A LK
Sbjct: 254 PRMTYPPLHGPMRFP--------PSLSETNKGL-RGRGPPPSWASEPERPSILSASELKE 304
Query: 361 L---DDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSM 417
L D+LDA+AD+GWAG EVDY+E+L FSDD+E+ PK N+ + Q S
Sbjct: 305 LDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQ----GSNSPKENN----SEDQGSK 356
Query: 418 SSADSADAKRTREEGKDWAEA-VGASRVVRKAPDPQ---------------PPPRKLHGW 461
+S ++ + K T E + + + A V K P + PPP+ L
Sbjct: 357 ASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQ 416
Query: 462 APGPDYQ--KSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRARE 519
P PD Q G +Q + D ED+ +++ QSE+S AVERARKRREEEERR E
Sbjct: 417 HPPPDRQAVPGRPGPFPSKQQVAD-EDEIWKQRRRQQSEISAAVERARKRREEEERRMEE 475
Query: 520 ERLAACAAKLKQLDQKC----KQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGS 575
+R AACA KLK+LD+K KQ ++ EKE EK QE K
Sbjct: 476 QRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDR 535
Query: 576 PEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQ 635
QE +E Q E E +E + QK Q+ ++Q+
Sbjct: 536 ER--QQEKEKELEKE---------QEKQREMEKERKQEKEKELERQKEKEKELQKMKEQE 584
Query: 636 QQEQLYK 642
++ +L K
Sbjct: 585 KECELEK 591
Score = 246 bits (629), Expect = 1e-64
Identities = 257/901 (28%), Positives = 379/901 (42%), Gaps = 261/901 (28%)
Query: 1576 EERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPGSSLGT---------E 1626
+ + + + VQ P++ SS+ PP + + D G S+ T E
Sbjct: 1931 QTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAE 1990
Query: 1627 IWESS----------SQAL----PVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSG 1672
+W++ S+ L P Q P+ +W K +T+F S + +G K+ Q +SG
Sbjct: 1991 LWDNKVAPPAVLNDISKKLGPISPPQPPSVSAWNKPLTSFGSAPSS---EGAKNGQ-ESG 2046
Query: 1673 VDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSE-QKDSEQGS 1731
+++ ++ + A +S + E S + EPK K+ P + QK +
Sbjct: 2047 LEIGTDTIQFGAPASNGNENEVVPVLSEKSADKIPEPKEQRQKQPRAGPIKAQKLPDLSP 2106
Query: 1732 GQSKEHRPGPIGNERSLKNRKGS-------EGAERLQGAVV-----------PPVNGVEI 1773
++KEH+PGPIG ERSLKNRK EG E+ A V V+ +
Sbjct: 2107 VENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEKPSPATVRSTDPVTTKETKAVSEMST 2166
Query: 1774 HVDSVLPVPPIEFGVSPKDS--DFSLPPGSASGPTGSPVVKLQDALASNAGLTQSIPILR 1831
+ +++ V E+G + K+S D++ P S + K++D L +N L ++P+ +
Sbjct: 2167 EIGTMISVSSAEYGTNAKESVTDYTTPSSSLPNTVATNNTKMEDTLVNNVPLPNTLPLPK 2226
Query: 1832 RDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGAS 1891
R+ IQ++ L+ + T LT KMESARKAWENSP++ E+ SP + PP + G S
Sbjct: 2227 RET-IQQSSSLTSVPPTTFSLTFKMESARKAWENSPNVREKGSP---VTSTAPPIATGVS 2282
Query: 1892 SG------VNYSSFGGVSMPPMPVASVAPSASMPGS------------------------ 1921
S NY+SF SMP +PVASV P+AS+ G+
Sbjct: 2283 SSASGPSTANYNSFSSASMPQIPVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKV 2342
Query: 1922 ---HLPPLYLDGHVFASQPRLVPQTIPQQQS-----YQQAAAAQ---------------- 1957
L L SQ +P I QQQ Q+AAAQ
Sbjct: 2343 KPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQH 2402
Query: 1958 -------------------------QIPISLHTSLQA--QAQLGLRGGLPVSQSQEIF-S 1989
QIPI ++ LQ QAQL L G VSQ+QE+F S
Sbjct: 2403 ARLAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSS 2462
Query: 1990 SLQPFRSQ-VYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMSGN 2048
SLQP+RSQ +M SLS PS ++ GTA+ FP +Q E+ K QSG +Q S
Sbjct: 2463 SLQPYRSQPAFMQSSLSQPSVVL--SGTAI----HNFPTVQHQELAKAQSGLAFQQTSNT 2516
Query: 2049 Q--ALVYEGQLSQAAGLGASQMLD------------------------------------ 2070
Q ++YE QL QA+GLG SQ++D
Sbjct: 2517 QPIPILYEHQLGQASGLGGSQLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSP 2576
Query: 2071 SQLPQLTMP-------LPRYGSGQQPLI-LPQSIQ------LPPGQSLSVGAP------- 2109
S L Q+T+P LP +GS QPLI LPQ++Q P Q+ S+ P
Sbjct: 2577 SALQQVTVPLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPF 2636
Query: 2110 RRIPPPGSQPPVLNTSREPSQMEMKGFHFA-DSKQNVP---SGGPVPSPQTYRPSSASPS 2165
R + P G+Q ++ T+ + S+ME+K F D K P P+ +R +S SP+
Sbjct: 2637 RGLIPAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTPPIAGRSTTPTSSPFRATSTSPN 2696
Query: 2166 GKPS--GSAVNMGSVQG-------------HYVQQAKQRVD-------------EKPSLG 2197
+ S S V Q + QAKQR + + +G
Sbjct: 2697 SQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAPQAKQRAEVLQSTQRFFSEQQQSKQIG 2756
Query: 2198 AVKLQE-----------------------------APSAASQMKRTGAIKPRAVKVEESK 2228
K Q+ APS A++ RTG IKP+A+K EE+K
Sbjct: 2757 GGKAQKVDSDSSKPPETLTDPPGVCQEKVEEKPPPAPSIATKPVRTGPIKPQAIKTEETK 2816
Query: 2229 A 2229
+
Sbjct: 2817 S 2817
Score = 53.9 bits (128), Expect = 2e-06
Identities = 185/917 (20%), Positives = 310/917 (33%), Gaps = 137/917 (14%)
Query: 1372 EEWETASESSDFS--ERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVD 1429
EE ET SESSDF +R R+ G ++ DS++ S K +L KR +RP
Sbjct: 1240 EESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKRE---ERPE-- 1294
Query: 1430 RQSRKLEPGGFGEKPVRPGGG---DTSPRYESQQNGTPLKVKRSPDEALPG--------- 1477
+KPV+P D R +++ P R D+A PG
Sbjct: 1295 -----------NKKPVKPHSSFKPDNHVRIDNRLLEKPYV--RDDDKAKPGFLPKGEPTR 1341
Query: 1478 -GLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQF---D 1533
G G G P ++ +++++ P GE +QF
Sbjct: 1342 RGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIA 1401
Query: 1534 LNYGSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKE-QAVQVPVKGR 1592
+ E P E + + RRL E E K + V VP G
Sbjct: 1402 ADKRPPKFER-KFDPARERPRRQRPTRPPRQDKPPRFRRLREREAASKSNEVVAVPTNGT 1460
Query: 1593 GLSSRIPPRFAKKQNNLCLEQGDVTVP-----GSSLGTEIWESSSQALPVQAPANDSWRK 1647
+ P N L G+ T S E WE++S++ +K
Sbjct: 1461 VNNVAQEP-----VNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERRERDEKK 1515
Query: 1648 AVTAFSST-----------ETGSAEQGFKSSQ--------GDSGVDLSA--------ESR 1680
+ T + A++ F S + G++G S E R
Sbjct: 1516 NADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERR 1575
Query: 1681 ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEH-RP 1739
+ S + P+ +P +G L + H+E P + QK+S+ +G+ +E +P
Sbjct: 1576 SGPPSKSGKRGPFDD-QPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKP 1634
Query: 1740 GPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPP 1799
GP +K E + L + V I +D V IE S + D
Sbjct: 1635 GP---------KKPKEKVDALSQFDLNNYASVVI-IDDHPEVTVIEDPQSNLNDD----- 1679
Query: 1800 GSASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESA 1859
G + +LQD Q I + + + ++ G S S K +
Sbjct: 1680 GFTEVVSKKQQKRLQDEERRKKE-EQVIQVWNKKNANEK--GRSQTSKLPPRFAKKQATG 1736
Query: 1860 RKAWENSPSLPE-QSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAP---- 1914
+ ++S S+P S+P + P+S A + + P+P +++AP
Sbjct: 1737 IQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLAS 1796
Query: 1915 -SASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQL 1973
SA +P S L P+ V AS P S A+A PI S A +
Sbjct: 1797 TSAPVPASPLAPVSASASVSASVPASTSAAAITSSS-APASAPAPTPILASVSTPASVTI 1855
Query: 1974 GLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGT------ALKPPYSAFPG 2027
+P+ S + S+ P + P+ S P+ +++ T P +
Sbjct: 1856 LASASIPILAS-ALASTSAPTPA-----PAASSPAAPVITAPTIPASAPTASVPLAPASA 1909
Query: 2028 MQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQ 2087
P P S P + Q + Q SQ P + +P + +G
Sbjct: 1910 SAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTPNGT 1969
Query: 2088 QPLILPQSIQLPPGQSLSVGA--PRRIPPPG--------------SQPPVLNTSREPSQM 2131
+ +SIQ P ++ PP QPP ++ +P
Sbjct: 1970 DYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISPPQPPSVSAWNKP--- 2026
Query: 2132 EMKGFHFADSKQNVPSG---GPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQ 2188
+ F A S + +G G T + + + +G + + + + K+
Sbjct: 2027 -LTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNGNENEVVPVLSEKSADKIPEPKE 2085
Query: 2189 RVDEKPSLGAVKLQEAP 2205
+ ++P G +K Q+ P
Sbjct: 2086 QRQKQPRAGPIKAQKLP 2102
Score = 32.3 bits (72), Expect = 5.3
Identities = 35/111 (31%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 2102 QSLS-VGAPRRIPPPGSQPPVL--NTSREPSQ--MEMKGFHFAD-SKQNVPSGGPVPSPQ 2155
QSL VG RR+PPP + P + N +P+ + G +A +Q+ P P
Sbjct: 43 QSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKTPEVPPA 102
Query: 2156 TYRPSSASP---SGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQE 2203
+P A+P + P A N QG +Q Q E PSL A QE
Sbjct: 103 QPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQE 153
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 71.6 bits (174), Expect = 8e-12
Identities = 319/1603 (19%), Positives = 542/1603 (33%), Gaps = 276/1603 (17%)
Query: 288 SPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERA 347
+P+ S G V+R L L V R+ + D G+E LR L + +
Sbjct: 9 TPRGSGTNGYVQRN------LSL---VRGRRGERPDYKGEEE-------LRRLEAALVKR 52
Query: 348 PRPTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVV--------KD 399
P P I++ E + ++ + ++ + EE Y E+ + +E+V KD
Sbjct: 53 PNPDILDHERKRRVELRCLELEE----MMEEQGYEEQ------QIQEKVATFRLMLLEKD 102
Query: 400 GRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLH 459
P P QR + A+ + E A + S V + DPQ R+
Sbjct: 103 VNPGGKEETPG-QRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAK 161
Query: 460 GWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRR-------EE 512
AP P S + +S K+ K ++ + S + R RK+ E
Sbjct: 162 QPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE 221
Query: 513 EERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVH 572
E + R+ R +K K D+K K++R A K + S SA+ AS +
Sbjct: 222 SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPK--SRRAHRSTSADSASSSDTS---R 276
Query: 573 KGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQ 632
S A+ T +P SPA + + E G+ + + + S P +Q
Sbjct: 277 SRSRSAAAKTHTTALAGRSP--SPASGRRGEGDAPFSEPGTTSTQ---RPSSPETATKQP 331
Query: 633 QQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHP-------QMLGFDPRWMMMPSYMDPRI 685
+++ + P PS + + P P + G P+ + +
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV 391
Query: 686 TPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWS 745
P PS P+ P E L + S ++ P Q KV+ S S
Sbjct: 392 NP--------PSEASPTRDRSPPKSPEKLPQS---SSSESSPPSPQPTKVSRHASSSPES 440
Query: 746 PEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYL 805
P+ P P P S ++ +N S A ++ + R + R
Sbjct: 441 PK----------PAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATA 490
Query: 806 SAFDKKAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDEKK 865
+++ + + G PQ + G +++ P +
Sbjct: 491 KRGRSRSR-------TPTKRGHSRSRSPQWRRSRSAQRWGRSRS-------PQRRGRSRS 536
Query: 866 PECGSWDVSHQPE------TADTAHGVERETPREGTAFNISSWDKNGSPNKQPS--SEPE 917
P+ W S + +A R G + + + + S ++ P+
Sbjct: 537 PQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRS 596
Query: 918 WTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEES---TRLA 974
TP R S S+ P + GR+R P ++ V + + ++ S R
Sbjct: 597 RTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRG 656
Query: 975 KEKEQSPT----------------------AEKDEDEENDASLANSSTTTLEDKGPGHA- 1011
+ + ++P A + S + +L +G H+
Sbjct: 657 RSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSR 716
Query: 1012 TFGREATKFEEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGF 1071
T R E+ +K+ ++ S+ P MK++ R +A+ R
Sbjct: 717 TPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSR---- 772
Query: 1072 REFTFRGRPAGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVA 1131
+ R +G + RS SSQ + R +R P K + +
Sbjct: 773 --LSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTP 830
Query: 1132 S-ETHSEGSEYEEL----PKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSE 1186
S ++HS S + ++ P R+ S NE S+ + S C E
Sbjct: 831 SRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRS----------------CFE 874
Query: 1187 DHSGLDAKSRGP--RAFGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQ-----EY 1239
+ KSR P + + PPR+ + R++ SP + K+ S Q
Sbjct: 875 SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSS 934
Query: 1240 GPSDTCGSRRPTDRDYVPDSYRHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPF 1299
PS + + R T R R S + S + ++ +
Sbjct: 935 SPSPSRVTSRTTPR---------------RSRSVSPCSNVESRLLPRYSHSGSSSPDTKV 979
Query: 1300 RRRRPPRQDKP------PRFRRLRQERESL-GLWGP---EEEPHLLAGQWPGRPKLCSGD 1349
+ PPRQ P+ + SL G P E+ L PG LC+G
Sbjct: 980 KPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGV 1039
Query: 1350 KSGT------VGRRSPEL--SYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQV 1401
KS T G S +L Q S DH S++S R+ E P + SQ
Sbjct: 1040 KSSTPPGESYFGVSSLQLKGQSQTSPDH-------RSDTSSPEVRQSHSESPSLQSKSQT 1092
Query: 1402 D--GGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGFGEKP-VRPGGGDTSPRYES 1458
GG S +S ELA RS P+ RQ R G F P ++ G R++S
Sbjct: 1093 SPKGGRSRSS-SPVTELASRS-----PI--RQDR----GEFSASPMLKSGMSPEQSRFQS 1140
Query: 1459 QQNGTP------------LKVKRSPDE-ALPGGLSGCSS----GSGHSPYALERAAHASA 1501
+ P L+ S ++ ALP +S SP+ ++ +S
Sbjct: 1141 DSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSL 1200
Query: 1502 DLPE-----------ASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSA--IIENCGSSP 1548
+ A S KE A P + + E M+ + + A I+ + SS
Sbjct: 1201 VFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHL-SSE 1259
Query: 1549 GEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNN 1608
+E + +E L + + + +AV+VP SS P F+ +
Sbjct: 1260 LKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMA---SSWGGPHFSPEHKE 1316
Query: 1609 LCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSS- 1667
L + + +S G+ + +S L + T FSS F +
Sbjct: 1317 L----SNSPLRENSFGSPLEFRNSGPLGTEMN---------TGFSSEVKEDLNGPFLNQL 1363
Query: 1668 QGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPK-PSEQKD 1726
+ D +D+ +S SS SS SP K S ++ P D+ P+ PS ++
Sbjct: 1364 ETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDA----VPRTPSRERS 1419
Query: 1727 SEQGSGQSKEHRP------GPIGNERSLKNRKGSEGAERLQGA 1763
S S + K+ P G+ L++ G+ L G+
Sbjct: 1420 SSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGS 1462
Score = 60.5 bits (145), Expect = 2e-08
Identities = 298/1382 (21%), Positives = 445/1382 (32%), Gaps = 284/1382 (20%)
Query: 904 KNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIK 963
++ SP K P P+ + S S P + R S P + P K +E+
Sbjct: 401 RDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSP-ESP--KPAPAPGSHREISSSP 457
Query: 964 QELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEE 1023
R ++K S T + + A + + P R +
Sbjct: 458 TSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRS--RSRTPTKRGHSRSRSPQWRR 515
Query: 1024 EKPDKAW-EARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRPAG 1082
+ + W +R P+ +R W + Q RGR R R R
Sbjct: 516 SRSAQRWGRSRSPQRRGRSRSPQRPGW-------SRSRNTQRRGRSRSARRGRSHSRSPA 568
Query: 1083 GNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHS-EGSEY 1141
G RS + R GR R R AR R RRR S T + G
Sbjct: 569 TRG-----------RSRSRTPARRGRSRS-RTPARRRSRSRTPTRRRSRSRTPARRGRSR 616
Query: 1142 EELPKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRAF 1201
P RRR R + R S + R S RS +SR P
Sbjct: 617 SRTPARRRSR-----TRSPVRRRSRS---RSPARRSGRS-------------RSRTPARR 655
Query: 1202 GRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSYR 1261
GR+ + G R ++ S +S++P +RR R P R
Sbjct: 656 GRSRSRTPARRGRSRSRTPARRSGRSRSRTP--------------ARRGRSRSRTPRRGR 701
Query: 1262 -HPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLR-QE 1319
+ RG SR +R S +N+ +R R + P ++ R
Sbjct: 702 SRSRSLVRRGRSHSRTPQRRG-----RSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISS 756
Query: 1320 RESLGLWGPEEEP-------HLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANE 1372
R S L P + L+G P C KS T RRS S Q +
Sbjct: 757 RRSRSLSSPRSKAKSRLSLRRSLSGSSP-----CPKQKSQTPPRRSRSGSSQPKA----- 806
Query: 1373 EWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQS 1432
S RR R S P Q + K +++S SS P
Sbjct: 807 -------KSRTPPRRSR--SSSSPPPKQ-----------KSKTPSRQSHSSSSP-----H 841
Query: 1433 RKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLK---VKRSPDEALPGGLSGCSSGSGHS 1489
K++ G P R G TSP+ ++Q+ TP + + SPD L S SG S
Sbjct: 842 PKVKSG----TPPRQ-GSITSPQ-ANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSS 895
Query: 1490 PYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPG 1549
P + +++ P SS K + +PR + GSS
Sbjct: 896 PPRV-KSSTPPRQSPSRSSSPQPKVKAIISPRQR------------------SHSGSSSP 936
Query: 1550 EESEVGSMV---GEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQ 1606
S V S + + + RLL + VK PPR +
Sbjct: 937 SPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVK-----PETPPRQSHSG 991
Query: 1607 NNLCLEQGDV-TVPGSSLGTE----IWESSSQALPVQAPANDSWRKAVTAFSSTETGSAE 1661
+ + T PG SL E S +L P + S V SST G +
Sbjct: 992 SISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVK--SSTPPGESY 1049
Query: 1662 QGFKSSQ--GDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSH-KEQA 1718
G S Q G S S SS Q S +L+ + + P ++ S E A
Sbjct: 1050 FGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELA 1109
Query: 1719 PKPSEQKDSEQ-------GSGQSKEH-------RPGPIGNERSLKNRKGSEGAERLQGAV 1764
+ ++D + SG S E P + SL + E AE +
Sbjct: 1110 SRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMA 1169
Query: 1765 VPPVNGVEI----HVDSVLPVP---PIEFGVSPKDSDFSLPPGSASGPTGSPVVKLQDAL 1817
+PP D P P E + KD+ PP SG SP K Q++
Sbjct: 1170 LPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDT-LRTPPRERSGAGSSPETKEQNS- 1227
Query: 1818 ASNAGLTQSIPILRRDHHIQRAIGLS--PMSFPTADLTLKM-ESARKAWENSPSLPEQSS 1874
++P +D + + S P + L+ ++ E + +E+SP + E
Sbjct: 1228 --------ALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEE--- 1276
Query: 1875 PGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHVFA 1934
+P S+ + +S V +P M ++S G H P H
Sbjct: 1277 --------RPAVSLTLDQSQSQASLEAVEVPSM-------ASSWGGPHFSP----EHKEL 1317
Query: 1935 SQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPF 1994
S L + ++ + + ++T ++ + L G PF
Sbjct: 1318 SNSPLRENSFGSPLEFRNSG---PLGTEMNTGFSSEVKEDLNG---------------PF 1359
Query: 1995 RSQVYMHPSLSPPSTMILSGG---TALKPPYSAFPGMQPLEMVKPQSGSPYQPMSGNQAL 2051
+Q+ PSL S G + L P GM + + SP A+
Sbjct: 1360 LNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSI----SSPVL-----DAV 1410
Query: 2052 VYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRR 2111
+++ + +M D LP+ R GS PG G P R
Sbjct: 1411 PRTPSRERSSSASSPEMKDG-LPRTPSRRSRSGSS-------------PGLRDGSGTPSR 1456
Query: 2112 IPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPSSASPSG----- 2166
GS P + + R PS +G DS S P PQT RP S SPS
Sbjct: 1457 HSLSGSSPGMKDIPRTPS----RGRSECDS-----SPEPKALPQTPRPRSRSPSSPELNN 1507
Query: 2167 ---------KPSGSAVNMGSVQGHYVQQ-----AKQRVDEKPSLGAVKLQEAPSAASQMK 2212
S S+V+ +V + Q + Q +D KPS + E+ S+
Sbjct: 1508 KCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKA 1567
Query: 2213 RT 2214
+T
Sbjct: 1568 KT 1569
Score = 54.3 bits (129), Expect = 1e-06
Identities = 486/2451 (19%), Positives = 781/2451 (31%), Gaps = 423/2451 (17%)
Query: 10 KGKDGKSKYSTL---SLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSL 66
K KD K K +T S G A + RHG S +A P N PS
Sbjct: 338 KDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHG-GSPQPLATTPLSQEPVNPPSE 396
Query: 67 KSENKGNDP--NIVIVPKDGTGWANKQDQQDPKSSSATASQP--PESLPQPGLQKSVSNL 122
S + P + +P+ + ++ Q K S +S P P+ P PG + +S+
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456
Query: 123 Q----------KPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEF 172
K +S S + + G+ RG SR S SP+
Sbjct: 457 PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSR--SRSPQWR 514
Query: 173 PTLKAAG-GQDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELG 231
+ A G+ ++ + +G PG S R +N R G R S S SP G
Sbjct: 515 RSRSAQRWGRSRSPQRRGRSRSPQRPGWS-RSRNTQ--RRGRSRSARRGRSHSRSPATRG 571
Query: 232 SRNSSTGDGAPSSACTSDSKDPSLRPAQ-------------PVRKGASQFMGNVYHPPTY 278
S T P+ S S+ P+ R ++ P R+G S+
Sbjct: 572 RSRSRT----PARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRT 627
Query: 279 HDMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLR 338
+ S + G R P + R R P R+ + + R G SR
Sbjct: 628 RSPVRRRSRSRSPARRSGR-SRSRTPARRGRSRSRTPARRGRSRSRT-PARRSGRSRSRT 685
Query: 339 PLRQ--LVERAPRPTIINAENL--KGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEE 394
P R+ R PR + +L +G G +G E K K +
Sbjct: 686 PARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSE----RKNKSRTSQRRS 741
Query: 395 EVVKDGRPKWNSWDPRRQRQLSM-------------SSADSADAKRTREEGKDWAEAVGA 441
K + RR R LS S + S+ + + + G+
Sbjct: 742 RSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGS 801
Query: 442 SRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKP------PPRQKFI 495
S+ K+ + PPR+ + P QKS S +QS P PPRQ I
Sbjct: 802 SQPKAKS---RTPPRRSRSSSSPPPKQKSKTPS---RQSHSSSSPHPKVKSGTPPRQGSI 855
Query: 496 QSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPW 555
S + +RR E E LK + R ++
Sbjct: 856 TSPQANEQSVTPQRRSCFESSPDPE--------LKSRTPSRHSCSGSSPPRVKSSTPPRQ 907
Query: 556 SPSAEKASPQENGPAV-------HKGSPE-FPAQETPTTFPEEAPTVSPAVAQSNSSEEE 607
SPS +SPQ A+ H GS P++ T T P + +VSP +
Sbjct: 908 SPS-RSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPR 966
Query: 608 AREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQM 667
+GS + + K + PPR H + P P +T P P +
Sbjct: 967 YSHSGSSSPDTKVKPETPPR---------------QSHSGSISPYPKVKAQT--PPGPSL 1009
Query: 668 LGFDPRWMMMPSYMDPRITPTRTPVDFYPSALH-PSGLMKPMMPQES--------LNGTG 718
G P+ + V P +L +G+ P ES L G
Sbjct: 1010 SG--------SKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQS 1061
Query: 719 CRSEDQNCVPPLQERKVTPIDSPPV-----WSPEGYMALQSKGYPLPHPKSSDTLAMDMR 773
S D E + + +SP + SP+G + S P+ S + D
Sbjct: 1062 QTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSS--PVTELASRSPIRQD-- 1117
Query: 774 VRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRI-----GQE 828
FSAS G+S ++ F+ Y D +S + R+ ++
Sbjct: 1118 ---RGEFSASPMLKSGMSPEQSRFQSDSSSY-------PTVDSNSLLGQSRLETAESKEK 1167
Query: 829 LLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVER 888
+ PPQE+ A P Q + SP V D + D P + G
Sbjct: 1168 MALPPQEDA-TASPP---RQKDKFSPFP---VQDRPESSLVFKDTLRTPPRERSGAGSSP 1220
Query: 889 ETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLK 948
ET + +A SS D+ + S EP SS T S +++
Sbjct: 1221 ETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAV 1280
Query: 949 ALKVEDKEKE--LEKIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDK 1006
+L ++ + + LE + E +A + + ++ N NS + LE +
Sbjct: 1281 SLTLDQSQSQASLEAV------EVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFR 1334
Query: 1007 GPGHATFGREA-TKFEEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQAR 1065
G G E T F E K D E+ MK + R
Sbjct: 1335 NSG--PLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQS---------------TR 1377
Query: 1066 GRGRGFREFTFRG-RPAGGNGSGLCGGGVLGA--------RSIYCSS------------- 1103
G E + AG + + VL A RS SS
Sbjct: 1378 SSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSR 1437
Query: 1104 -QRSGRGRGLREFARP-------------EDCPRAKPRRRVASETHSEGSEYEELPKRRR 1149
RSG GLR+ + +D PR R R ++ E + P+ R
Sbjct: 1438 RSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRS 1497
Query: 1150 QRGS--------------ENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKS 1195
+ S +G+E S+ ++ + G RS G S++ + S
Sbjct: 1498 RSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQ-----RSRSGSSQELDVKPSAS 1552
Query: 1196 RGPRAFGRALPPRLSNCGYG-RRTFVSKESPHWQSK---SPGSSWQEYGPSDTCGSRRPT 1251
R+ + P + R+ S SP SK SP S P R
Sbjct: 1553 PQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAP 1612
Query: 1252 DRDYVPDSYRHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPP 1311
DS P A R S + S + E+ P PP+
Sbjct: 1613 RAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSP---EHPPKSRTAR 1669
Query: 1312 RFRRLRQERESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHAN 1371
R R E ++ P + + + +L +S + SPE + H
Sbjct: 1670 RGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSAS---SSPETRSRTPPRHRR 1726
Query: 1372 EEWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQ 1431
++ E ++ S R RR S P ++ G S K +RS S R R
Sbjct: 1727 SPSVSSPEPAEKS-RSSRRRRSASSPRTKTT-SRRGRSPSPKPRGLQRSRSRSRREKTRT 1784
Query: 1432 SRKLEPGGFGEKPV---------------RPGGGDTSPRYESQQNGTPLKVKRSPDEALP 1476
+R+ + G + R GG R ++Q + +R +
Sbjct: 1785 TRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRT 1844
Query: 1477 GGLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNY 1536
S S S SP +R+ ++ P + + ++ R+ + + +
Sbjct: 1845 PPTSRKRSRSRTSPAPWKRSRSRAS--PATHRRSRSRTPLISRRRSRSRTSPVSRRRSRS 1902
Query: 1537 GSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSS 1596
+++ S S V +T+++ R R++ ++ PV R S
Sbjct: 1903 RTSVTRR--RSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRS 1960
Query: 1597 RIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTE 1656
R PP ++ S S+ P+ + S VT S
Sbjct: 1961 RTPPVTRRR------------------------SRSRTSPITRRRSRSRTSPVTRRRSRS 1996
Query: 1657 TGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKE 1716
S +S S V + +RS L P + S P A +
Sbjct: 1997 RTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRS--RSPLAIRRRS 2054
Query: 1717 QAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAER-LQGAVVPPVNGVEIHV 1775
++ P + + R S ++R + A R G+ PPV +
Sbjct: 2055 RSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPV-ALNSSR 2113
Query: 1776 DSVLPVPPIEFGVSPKDSDFSLPPGSAS--GPTGSPVVKLQDALASNA-GLTQSIPILRR 1832
S P +SP D PG G + +P+ LQ A S G IP +R
Sbjct: 2114 MSCFSRP----SMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQR 2169
Query: 1833 ----DHHIQRAIGL-----------------------------------SPMSFPTADLT 1853
++H Q I L S + P A+L
Sbjct: 2170 TSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLA 2229
Query: 1854 LKMESARKAWEN-----SPSLP-------EQSSPGGAGSGIQPPSSVGASSGVNYSSFGG 1901
++ +A A N +P++P ++ A + P + A S VN +
Sbjct: 2230 SRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLAD--- 2286
Query: 1902 VSMPPMPVASVAPSASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPI 1961
P AP+ ++ G+ P A+ T P +Y ++ Q P
Sbjct: 2287 ------PRTPTAPAVNLAGARTPA------ALAALSLTGSGTPPTAANYPSSSRTPQAPA 2334
Query: 1962 SLH----TSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTA 2017
S + S A A + + G S+ + + M P+LS + T+
Sbjct: 2335 SANLVGPRSAHATAPVNIAG------SRTAAALAPASLTSARMAPALSGANL------TS 2382
Query: 2018 LKPPYSAF---------PGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQM 2068
+ P SA+ P + P S M+ +A ++ QA + +
Sbjct: 2383 PRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAP---SQSL 2439
Query: 2069 LDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPR-------------RIPPP 2115
L Q P+P S Q ++ Q+ + QSLS GA +P P
Sbjct: 2440 LPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAP 2499
Query: 2116 G------SQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPSSASPSGKPS 2169
G +PP +++PS + + + + S S + SS+S S S
Sbjct: 2500 GVPHSDVGEPPASTGAQQPSALAALQ-PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGS 2558
Query: 2170 GSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEA----PSAASQMKRTGA 2216
S+ + GS + A +RV ++E P+ A + +R+ +
Sbjct: 2559 SSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSS 2609
Score = 39.7 bits (91), Expect = 0.033
Identities = 276/1300 (21%), Positives = 415/1300 (31%), Gaps = 226/1300 (17%)
Query: 756 GYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYL----SAFDKK 811
G LP P+ S T R + S GR G + + +GEE L +A K+
Sbjct: 4 GIGLPTPRGSGTNGYVQR-----NLSLVRGRRG------ERPDYKGEEELRRLEAALVKR 52
Query: 812 AQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQN----LRCSPLEPDFVPDEKKPE 867
D +R+ L +E +++ G Q R LE D P K+
Sbjct: 53 PNPDILDHERKRRVELRCL-ELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEET 111
Query: 868 CGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSP---------NKQPSSEPEW 918
G ET A E++ R AF IS +GS KQP+ EP
Sbjct: 112 PGQRPAV--TETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEP-- 167
Query: 919 TPEP-----RSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRL 973
P+P SSSS+ P + ++ + ++ + K+ K K+ E ++
Sbjct: 168 -PKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK- 225
Query: 974 AKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEKPDKAWEAR 1033
K K +SPT + ++ + STT H + ++
Sbjct: 226 -KRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSA--------------- 269
Query: 1034 PPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRPAGGNGSGLCGGGV 1093
SSD +R R R T AG + S G
Sbjct: 270 ---SSSDT----------------------SRSRSRSAAAKTHTTALAGRSPSPASG--- 301
Query: 1094 LGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRGS 1153
RG G F+ P +P + T S YE+ K ++++ +
Sbjct: 302 -------------RRGEGDAPFSEPGTTSTQRP-SSPETATKQPSSPYEDKDKDKKEKSA 347
Query: 1154 ENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRAFGRALPPRLSNCG 1213
+ ER + + G S S+ P PP ++
Sbjct: 348 TRPSPSP--ERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEP-----VNPPSEASPT 400
Query: 1214 YGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSYRHPDAFGG-RGFE 1272
R S E S S S P T SR + P+S + A G R
Sbjct: 401 RDRSPPKSPEKLPQSSSSESS---PPSPQPTKVSRHASSS---PESPKPAPAPGSHREIS 454
Query: 1273 DSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFR------------RLRQER 1320
S RS + + + +R R R P K R R R Q R
Sbjct: 455 SSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWR 514
Query: 1321 ESLGL--WGPEEEPHLLA-GQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETA 1377
S WG P + P RP +S RR S + H+
Sbjct: 515 RSRSAQRWGRSRSPQRRGRSRSPQRP---GWSRSRNTQRRGRSRSARRGRSHSRSPATRG 571
Query: 1378 SESSDFSERR--------ERREGPGSEPDSQVDGGLSGASLG-EKKELAKRSFSSQRPVV 1428
S RR RR P + + A G + R S R V
Sbjct: 572 RSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPV 631
Query: 1429 DRQSRKLEPGGFGEKPVRPGG---GDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSG 1485
R+SR P R G T R ++ TP + RS P SG S
Sbjct: 632 RRRSR-------SRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRT-PARRSGRSRS 683
Query: 1486 SGHSPYALERAAHASADLPEASSKKAEKEAKLAAP-RAGEQGEAMKQFDLNYGSAIIENC 1544
+ R+ + S + P R G G + ++ + + S
Sbjct: 684 RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRS 743
Query: 1545 GSSPG-EESEVGSMVGEGFIEVLTKKQRRLLEEERRK--------KEQAVQVPVKGRGLS 1595
SSP ++S + S +K + RL RR K+++ P + R S
Sbjct: 744 NSSPEMKKSRISSRRSRSLSSPRSKAKSRL--SLRRSLSGSSPCPKQKSQTPPRRSRSGS 801
Query: 1596 S------RIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAV 1649
S R PPR ++ ++ +Q T S SSS P + ++
Sbjct: 802 SQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQS------HSSSSPHPKVKSGTPPRQGSI 855
Query: 1650 TAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGT-------LKPEEMS 1702
T+ + E Q + S +S D +SR S S SSP P S
Sbjct: 856 TSPQANEQSVTPQ--RRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSS 913
Query: 1703 GP-----GLAEPKADSHK-EQAPKPSEQKDSEQGSGQSKEHRPGPIGN-ERSLKNRKGSE 1755
P + P+ SH +P PS + + P N E L R
Sbjct: 914 SPQPKVKAIISPRQRSHSGSSSPSPSRVTSR---TTPRRSRSVSPCSNVESRLLPRYSHS 970
Query: 1756 GAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSPVVKLQD 1815
G+ V P + H S+ P P ++ PPG + + SP + +
Sbjct: 971 GSSSPDTKVKPETPPRQSHSGSISPYPKVK---------AQTPPGPSLSGSKSPCPQEK- 1020
Query: 1816 ALASNAGLTQSIP-ILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPS-LPEQS 1873
S L QS P L ++ + F + L LK +S + SP + S
Sbjct: 1021 ---SKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQS-----QTSPDHRSDTS 1072
Query: 1874 SPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHVF 1933
SP S + PS S S GG S PV +A + P+ D F
Sbjct: 1073 SPEVRQSHSESPS---LQSKSQTSPKGGRSRSSSPVTELASRS--------PIRQDRGEF 1121
Query: 1934 ASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQL 1973
++ P L P+Q +Q +++ P SL Q++L
Sbjct: 1122 SASPMLKSGMSPEQSRFQSDSSS--YPTVDSNSLLGQSRL 1159
Score = 38.9 bits (89), Expect = 0.057
Identities = 36/132 (27%), Positives = 55/132 (41%), Gaps = 10/132 (7%)
Query: 1636 PVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGT 1695
P PA R + ++ SS+ + S+ SS S S+ S SS++SS SS
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSS----SSSSSSSSSSSSSSSSSPSP 2651
Query: 1696 LKPEEMSGPGLAEPKADSHKEQAPK-PSEQKDSEQGS-----GQSKEHRPGPIGNERSLK 1749
KP + P A PK E+ + P + DS + S + RP P + R +
Sbjct: 2652 AKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQ 2711
Query: 1750 NRKGSEGAERLQ 1761
+ G+ R Q
Sbjct: 2712 SSSSERGSRRGQ 2723
Score = 33.9 bits (76), Expect = 1.8
Identities = 37/144 (25%), Positives = 50/144 (34%), Gaps = 16/144 (11%)
Query: 2032 EMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLP----RYGSGQ 2087
E Q SPY+ ++ + A S S P+ P P R+G
Sbjct: 325 ETATKQPSSPYEDKDKDK------KEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSP 378
Query: 2088 QPLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSRE----PSQMEMKGFHFADSKQ 2143
QPL Q P R PP S + +S PS K A S
Sbjct: 379 QPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSP 438
Query: 2144 NVPSGGPVPSPQTYRPSSASPSGK 2167
P P P+P ++R S+SP+ K
Sbjct: 439 ESPK--PAPAPGSHREISSSPTSK 460
Score = 31.6 bits (70), Expect = 9.1
Identities = 48/206 (23%), Positives = 68/206 (33%), Gaps = 26/206 (12%)
Query: 1615 DVTVPGSSLGTEIWESSSQALPVQAPAND--SWRKAVTAFSSTETGSAEQGFKSSQGDSG 1672
DV P +S G + AL PA + S + ++ SS+ + S+ SS G S
Sbjct: 2505 DVGEPPASTGAQ----QPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSS 2560
Query: 1673 VDLSAESRESSATSSQRSSPYGTLKPEEMSGPGL-AEPKADSHKEQAPKPSEQKDSEQGS 1731
D S + + P T P+E G EP K ++ S S S
Sbjct: 2561 SDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSS 2620
Query: 1732 GQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPK 1791
S + S + S + A P LP P SPK
Sbjct: 2621 SSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGP---------QALPKP-----ASPK 2666
Query: 1792 DSDFSLPPGS-ASGPTGSPVVKLQDA 1816
PPG S P+ L+D+
Sbjct: 2667 KP----PPGERRSRSPRKPIDSLRDS 2688
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 62.8 bits (151), Expect = 4e-09
Identities = 134/553 (24%), Positives = 196/553 (35%), Gaps = 54/553 (9%)
Query: 1581 KEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPGSSLGT-EIWESSSQALPVQA 1639
+ A + P GRG R PP AK + G V+ PG + GT + L + A
Sbjct: 88 RNPASRPPASGRG--ERAPP--AKNTS-----PGPVSSPGRASGTTRPGPLGQKGLRISA 138
Query: 1640 PANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQ----RSSPYGT 1695
+ KA A + SA +S G A +R S A ++ R +P
Sbjct: 139 EETVARGKATEAPKRSAL-SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 197
Query: 1696 LKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSE 1755
+P GP + A H P P+ ++ G G + + L + S
Sbjct: 198 PRPPT-EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 256
Query: 1756 GAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASG-PTGSPVVKLQ 1814
+ R G P + + + + P + KD+ +L P S+S T SP LQ
Sbjct: 257 PSAR--GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQ 314
Query: 1815 DALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSS 1874
+Q+ P L H S T L + A + PSL S
Sbjct: 315 ---------SQAPPTLPATPH---------SSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356
Query: 1875 PGGAGSGIQPPSSVGASSG--VNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHV 1932
P PPS S G ++ + PP+ + P + P LPPL
Sbjct: 357 PPAT-----PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP 411
Query: 1933 FASQPRLVPQTIPQQQSYQQAAA-AQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSL 1991
AS P L P P Q+ A Q P S S QA PVS S S
Sbjct: 412 PASPP-LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 470
Query: 1992 QPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFP-GMQPLEMVKPQSGSPYQPMSGNQA 2050
P + + SPP++ +S +A PP + P PL++ KP +P +
Sbjct: 471 PPSLAAPPLQVPPSPPASPPMSP-SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ 529
Query: 2051 LVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPG--QSLSVGA 2108
+ S S + L P P+ P++ +Q+PP S ++ A
Sbjct: 530 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQ----APPVLAAPLLQVPPSPPASPTLQA 585
Query: 2109 PRRIPPPGSQPPV 2121
PRR P PG V
Sbjct: 586 PRRPPTPGPDTSV 598
Score = 42.4 bits (98), Expect = 0.005
Identities = 124/556 (22%), Positives = 171/556 (30%), Gaps = 102/556 (18%)
Query: 1694 GTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKG 1753
G PE G S + A +P E+ +K PGP+ +
Sbjct: 67 GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPG------- 118
Query: 1754 SEGAERLQGAVVP-PVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG-SASGPT-GSP- 1809
R G P P+ + + + V + +PK S S SGPT G+P
Sbjct: 119 -----RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173
Query: 1810 --VVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSP 1867
+ + A + GL + P R PT + SA + P
Sbjct: 174 PAMARRSRAAGTEVGLPRPAPSARPRP-------------PTEGPRKSVSSASEHSTTEP 220
Query: 1868 SLPEQSSPGGAGSGIQPPSSVGASSGVNYSSF---GGVSMPPMPVASVAPSASMPGS--- 1921
S + P AG G+Q P+S SS S G S P A PS P
Sbjct: 221 SPAARRRPS-AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 279
Query: 1922 ----HLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRG 1977
+ P D P P + Q+ A +P + H+S L
Sbjct: 280 LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSS---SLTCQLAT 336
Query: 1978 GLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILS-GGTALKPPYSAFPG--MQPLEMV 2034
LP++ S P Q P +PPS S G L+ +S P + PL
Sbjct: 337 PLPLAPP----SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 392
Query: 2035 KPQSG---------SPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGS 2085
PQ+ +P P + QA A +L Q P P P
Sbjct: 393 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL--QAPFSPPPSP---- 446
Query: 2086 GQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNV 2145
P+ P S P S S P + PP + PP+ P+ M
Sbjct: 447 ---PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM------------ 491
Query: 2146 PSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAP 2205
S P PQ P +A P +Q AK P+L LQ P
Sbjct: 492 -SPSATPPPQAPPPLAAPP------------------LQLAKPPPQAPPALATPPLQALP 532
Query: 2206 SAASQMKRTGAIKPRA 2221
S + P A
Sbjct: 533 SPPASFPGQAPFSPSA 548
Score = 32.0 bits (71), Expect = 7.0
Identities = 76/360 (21%), Positives = 112/360 (31%), Gaps = 41/360 (11%)
Query: 409 PRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQ 468
P Q+ L +S+ ++ + E K A + GA R P P P +P +
Sbjct: 128 PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT-SGPTPGTP-------SPAMARR 179
Query: 469 KSSMGS-MFRQQSIEDKEDKPP---PRQKFIQSEMSEAVERARKRREEEE-----RRARE 519
+ G+ + + +PP PR+ + E + R +R
Sbjct: 180 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 239
Query: 520 ERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEF- 578
L++ A L + AR G R A P + P + P +P
Sbjct: 240 RSLSSSATPLSSPARSGPSAR--GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 297
Query: 579 PAQETPTTFPE-------EAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQR- 630
P +P P +AP PA S+S + +P S PP Q
Sbjct: 298 PLSSSPLATPSPSAALQSQAPPTLPATPHSSSL---TCQLATPLPLAPPSPSAPPSLQTL 354
Query: 631 -------QQQQQQQEQLYKMQHWQPVYP-PPSHPQRTFYPHHPQMLGFDPRWMMMPSYMD 682
Q +Q P PP P T P P L P
Sbjct: 355 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 414
Query: 683 PRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPP 742
P ++P TP P+AL L P P S S + PP+ P +PP
Sbjct: 415 PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS--PPVSPSATPPSQAPP 472
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 59.3 bits (142), Expect = 4e-08
Identities = 122/518 (23%), Positives = 177/518 (34%), Gaps = 45/518 (8%)
Query: 1624 GTEIWESSSQALPVQA---PANDSWRKAVTAFSSTETGSAEQGFKSSQ------GDSGVD 1674
G I ES+ +A P + PA+ +A A +++ + G S G G+
Sbjct: 67 GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 126
Query: 1675 LSAESR--ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQG-- 1730
+SAE AT + + S + SGP P + S +E G
Sbjct: 127 ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARR-----SRAAGTEVGLP 181
Query: 1731 -SGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVS 1789
S RP G +S+ + E A P G + P +S
Sbjct: 182 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ-------RPASRSLS 234
Query: 1790 PKDSDFSLPPGSASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPT 1849
+ S P S G+P + GL P A L P+S +
Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS--S 292
Query: 1850 ADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASSG--VNYSSFGGVSMPPM 1907
+ L SA + PSL SP PPS S G ++ + PP+
Sbjct: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPAT-----PPSQATTSLGSPTLQATHSFLPSPPL 347
Query: 1908 PVASVAPSASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAA-AQQIPISLHTS 1966
+ P + P LPPL AS P L P P Q+ A Q P S S
Sbjct: 348 SPLATPPPQAPPALALPPLQAPPSPPASPP-LSPLATPSPQAPNALAVHLLQAPFSPPPS 406
Query: 1967 LQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFP 2026
QA PVS S S P + + SPP++ +S +A PP + P
Sbjct: 407 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP-SATPPPQAPPP 465
Query: 2027 -GMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGS 2085
PL++ KP +P + + S S + L P P+
Sbjct: 466 LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ--- 522
Query: 2086 GQQPLILPQSIQLPPG--QSLSVGAPRRIPPPGSQPPV 2121
P++ +Q+PP S ++ APRR P PG V
Sbjct: 523 -APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV 559
Score = 37.0 bits (84), Expect = 0.22
Identities = 129/553 (23%), Positives = 174/553 (31%), Gaps = 133/553 (24%)
Query: 1686 SSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNE 1745
S+ R+ P T +P SG G P A K +P P G+ RPGP+G +
Sbjct: 73 SAPRAGPTRTSRPPA-SGRGERAPPA---KNTSPGPVSSPGRASGTT-----RPGPLGQK 123
Query: 1746 RSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPG-SASG 1804
G+ I + V + +PK S S SG
Sbjct: 124 ------------------------GLRISAEET--VARGKATEAPKRSALSAGARRDTSG 157
Query: 1805 PT-GSP---VVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESAR 1860
PT G+P + + A + GL + P R PT + SA
Sbjct: 158 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRP-------------PTEGPRKSVSSAS 204
Query: 1861 KAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSF---GGVSMPPMPVASVAPSAS 1917
+ PS + P AG G+Q P+S SS S G S P A PS
Sbjct: 205 EHSTTEPSPAARRRPS-AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP 263
Query: 1918 MPGS--HLPPLYLDGHVFASQPRLVP-QTIPQQQSYQQAAAAQQIPISLHT------SLQ 1968
P L P + + P L P + P A + P SL T +
Sbjct: 264 KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPP 323
Query: 1969 AQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGM 2028
+QA L G P Q+ F P S + P +PP+ + PP A P
Sbjct: 324 SQATTSL--GSPTLQATHSFLPSPPL-SPLATPPPQAPPALAL--------PPLQAPPS- 371
Query: 2029 QPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQ 2088
P + P P++ QA A +L Q P P P
Sbjct: 372 -------PPASPPLSPLATPSP--------QAPNALAVHLL--QAPFSPPPSP------- 407
Query: 2089 PLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSG 2148
P+ P S P S S P + PP + PP+ P+ M S
Sbjct: 408 PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-------------SP 454
Query: 2149 GPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAPSAA 2208
P PQ P +A P +Q AK P+L LQ PS
Sbjct: 455 SATPPPQAPPPLAAPP------------------LQLAKPPPQAPPALATPPLQALPSPP 496
Query: 2209 SQMKRTGAIKPRA 2221
+ P A
Sbjct: 497 ASFPGQAPFSPSA 509
Score = 32.3 bits (72), Expect = 5.3
Identities = 56/224 (25%), Positives = 69/224 (30%), Gaps = 23/224 (10%)
Query: 554 PWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEARE--A 611
P SP A + N AVH F +P +P SP V+ S + +A A
Sbjct: 377 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436
Query: 612 GSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQM---- 667
P Q + PP Q Q PPP P P +
Sbjct: 437 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496
Query: 668 LGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCV 727
F + PS P ++P TP P L L P P S
Sbjct: 497 ASFPGQAPFSPSASLP-MSPLATPPPQAPPVLAAPLLQVPPSPPAS-------------- 541
Query: 728 PPLQ--ERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLA 769
P LQ R TP V P +AL P P S TL+
Sbjct: 542 PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
Score = 32.0 bits (71), Expect = 7.0
Identities = 48/206 (23%), Positives = 66/206 (32%), Gaps = 26/206 (12%)
Query: 556 SPSAEKASPQENGPAVHKGSPEFPA----------------QETPT---TFPEEAPTVSP 596
S + +SP +GP+ +G+P PA Q TP P P S
Sbjct: 235 SSATPLSSPARSGPSA-RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293
Query: 597 AVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHP 656
+A + S + A Q + PP + L + P PP P
Sbjct: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPP--SQATTSLGSPTLQATHSFLP--SPPLSP 349
Query: 657 QRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNG 716
T P P L P P ++P TP P+AL L P P S
Sbjct: 350 LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 409
Query: 717 TGCRSEDQNCVPPLQERKVTPIDSPP 742
S + PP+ P +PP
Sbjct: 410 QAPFSPPAS--PPVSPSATPPSQAPP 433
>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
Length = 1012
Score = 58.5 bits (140), Expect = 7e-08
Identities = 154/684 (22%), Positives = 231/684 (33%), Gaps = 97/684 (14%)
Query: 1588 PVKGR--GLSSRIPPRFAKKQNNLC-LEQGDVTVPGSSLG-----TEIWESSSQALPVQA 1639
PVK GLS + R + + ++ L G P S G E SS + P A
Sbjct: 4 PVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAA 63
Query: 1640 P--ANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLK 1697
+NDS + V + A KS++ +++++ E+ TSS+++ +
Sbjct: 64 STSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE-KVASDTEEADRTSSKKTKTQEISR 122
Query: 1698 PEEMS-GPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEG 1756
P S G G +DS S+ KD +Q + + P P NE
Sbjct: 123 PNSPSEGEG---ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD-----SDSS 174
Query: 1757 AERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSP------V 1810
A++ PP L P GV+P S S PPG+ PT P V
Sbjct: 175 AQQQMLQAQPPA----------LQAPT---GVTPAPS--SAPPGTPQLPTPGPTPSATAV 219
Query: 1811 VKLQDALASNAGLTQSIPILRRDH-HIQRAIGLSPMSFPTADLTLKME-----SARKAWE 1864
AS A P H HIQ+A L P P+
Sbjct: 220 PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 279
Query: 1865 NSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSS----FGGVSMPPMPVASVAPSASMPG 1920
PS P + P G G P S+ A + + FG +PP AP + P
Sbjct: 280 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFG---LPPQASQGQAPLGTSPA 336
Query: 1921 SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP 1980
+ P L + ASQ L Q P++Q A A T+ Q LP
Sbjct: 337 AAYPHTSLQ--LPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQ--------LP 386
Query: 1981 VSQSQEI---FSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQ 2037
Q+ + S PF + P PP+ LS + PP + P +Q + +P
Sbjct: 387 APQAHKHPPHLSGPSPFSMNANLPP---PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPL 443
Query: 2038 SGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQ 2097
SP QP Q+ + G Q+ P P + Q P +
Sbjct: 444 PSSPAQPPGLTQSQNLPPPPASHPPTGLHQV---------APQPPF--AQHPFVPGGPPP 492
Query: 2098 LPPGQSLSVGAPRRIPPPGSQPPVLNTSREPS-------------QMEMKGFHFADSKQN 2144
+ P S P P +QPP + Q++ + A+ ++
Sbjct: 493 ITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPES 552
Query: 2145 VPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEA 2204
P PSP+ P+ S SA + Y A+ + P G+ ++
Sbjct: 553 PPPPPRSPSPE---PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKR 609
Query: 2205 PSAASQMKRTGAIKPRAVKVEESK 2228
A + KR K R + E +
Sbjct: 610 EEAIEKAKREAEQKAREEREREKE 633
Score = 40.4 bits (93), Expect = 0.020
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 18/118 (15%)
Query: 495 IQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVP 554
+ + EA+E+A++ E E++AREER ++ +K K+ + E ++AE+
Sbjct: 605 LAKKREEAIEKAKR---EAEQKAREER--------EREKEKEKEREREREREREAERAAK 653
Query: 555 WSPSAEK---ASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAR 609
S SA + + PQ +GP + S E P PTT P + P + E AR
Sbjct: 654 ASSSAHEGRLSDPQLSGPGHMRPSFEPP----PTTIAAVPPYIGPDTPALRTLSEYAR 707
Score = 38.1 bits (87), Expect = 0.097
Identities = 109/570 (19%), Positives = 183/570 (32%), Gaps = 92/570 (16%)
Query: 533 DQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAP 592
D + A + QA+ +P+ +P P G+P+ P + P
Sbjct: 166 DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP----GTPQLPTPGPTPSATAVPP 221
Query: 593 TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP 652
SP +Q+ ++ +A A P + +L P Q+ + H P +PP
Sbjct: 222 QGSPTASQA-PNQPQAPTAPVPHTHIQQAPALHP--------QRPPSPHPPPHPSP-HPP 271
Query: 653 -------------PSHPQRTFY---PHHPQMLGFDPRWMM----MPSYMDPRITPTRTPV 692
PSH Q + P P L P P + P+ + + P+
Sbjct: 272 LQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPL 331
Query: 693 DFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMAL 752
P+A +P ++ Q +L E PL + P PP A
Sbjct: 332 GTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKP---PPTTPIPQLPAP 388
Query: 753 QSKGYPLPHPKSSDTLAMDMRVRNESSFS--ASLGRAGGVSAQRDLFEERGEEYLSAFDK 810
Q+ +P PH +M+ + + +SL SA + + S
Sbjct: 389 QAHKHP-PHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ---SQPLP 444
Query: 811 KAQADFDSCISSQRI----------GQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFV 860
+ A SQ + G + P Q PGG P+ P
Sbjct: 445 SSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPP------PITPPTC 498
Query: 861 PDEKKPECGSWDVSHQPETADTAHGVE----RETPREGTAFNISSWDKNGSPNKQPSSEP 916
P P G + P + A G P + D P P
Sbjct: 499 PSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPR 558
Query: 917 EWTPEPRS-SSSQHPEQTGR-----------TRRSGPIKKPVLKALKVEDKEKELEKIKQ 964
+PEP + H Q+ R R+ P+ + + +E+ +EK K+
Sbjct: 559 SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKR 618
Query: 965 ELGEESTR-LAKEKEQSPTAEKDEDEENDASLANSSTTTLED--------KGPGHATFGR 1015
E +++ +EKE+ E++ + E +A A ++++ + GPGH
Sbjct: 619 EAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMR--- 675
Query: 1016 EATKFEEEEKPDKAWEARPPRESSDVPPMK 1045
E P A PP D P ++
Sbjct: 676 -----PSFEPPPTTIAAVPPYIGPDTPALR 700
>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 58.5 bits (140), Expect = 7e-08
Identities = 154/684 (22%), Positives = 231/684 (33%), Gaps = 97/684 (14%)
Query: 1588 PVKGR--GLSSRIPPRFAKKQNNLC-LEQGDVTVPGSSLG-----TEIWESSSQALPVQA 1639
PVK GLS + R + + ++ L G P S G E SS + P A
Sbjct: 558 PVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAA 617
Query: 1640 P--ANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLK 1697
+NDS + V + A KS++ +++++ E+ TSS+++ +
Sbjct: 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE-KVASDTEEADRTSSKKTKTQEISR 676
Query: 1698 PEEMS-GPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEG 1756
P S G G +DS S+ KD +Q + + P P NE
Sbjct: 677 PNSPSEGEG---ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD-----SDSS 728
Query: 1757 AERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSP------V 1810
A++ PP L P GV+P S S PPG+ PT P V
Sbjct: 729 AQQQMLQAQPPA----------LQAPT---GVTPAPS--SAPPGTPQLPTPGPTPSATAV 773
Query: 1811 VKLQDALASNAGLTQSIPILRRDH-HIQRAIGLSPMSFPTADLTLKME-----SARKAWE 1864
AS A P H HIQ+A L P P+
Sbjct: 774 PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833
Query: 1865 NSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSS----FGGVSMPPMPVASVAPSASMPG 1920
PS P + P G G P S+ A + + FG +PP AP + P
Sbjct: 834 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFG---LPPQASQGQAPLGTSPA 890
Query: 1921 SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP 1980
+ P L + ASQ L Q P++Q A A T+ Q LP
Sbjct: 891 AAYPHTSLQ--LPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQ--------LP 940
Query: 1981 VSQSQEI---FSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQ 2037
Q+ + S PF + P PP+ LS + PP + P +Q + +P
Sbjct: 941 APQAHKHPPHLSGPSPFSMNANLPP---PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPL 997
Query: 2038 SGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQ 2097
SP QP Q+ + G Q+ P P + Q P +
Sbjct: 998 PSSPAQPPGLTQSQNLPPPPASHPPTGLHQV---------APQPPF--AQHPFVPGGPPP 1046
Query: 2098 LPPGQSLSVGAPRRIPPPGSQPPVLNTSREPS-------------QMEMKGFHFADSKQN 2144
+ P S P P +QPP + Q++ + A+ ++
Sbjct: 1047 ITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPES 1106
Query: 2145 VPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEA 2204
P PSP+ P+ S SA + Y A+ + P G+ ++
Sbjct: 1107 PPPPPRSPSPE---PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKR 1163
Query: 2205 PSAASQMKRTGAIKPRAVKVEESK 2228
A + KR K R + E +
Sbjct: 1164 EEAIEKAKREAEQKAREEREREKE 1187
Score = 40.4 bits (93), Expect = 0.020
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 18/118 (15%)
Query: 495 IQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVP 554
+ + EA+E+A++ E E++AREER ++ +K K+ + E ++AE+
Sbjct: 1159 LAKKREEAIEKAKR---EAEQKAREER--------EREKEKEKEREREREREREAERAAK 1207
Query: 555 WSPSAEK---ASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAR 609
S SA + + PQ +GP + S E P PTT P + P + E AR
Sbjct: 1208 ASSSAHEGRLSDPQLSGPGHMRPSFEPP----PTTIAAVPPYIGPDTPALRTLSEYAR 1261
Score = 38.1 bits (87), Expect = 0.097
Identities = 109/570 (19%), Positives = 183/570 (32%), Gaps = 92/570 (16%)
Query: 533 DQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAP 592
D + A + QA+ +P+ +P P G+P+ P + P
Sbjct: 720 DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP----GTPQLPTPGPTPSATAVPP 775
Query: 593 TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP 652
SP +Q+ ++ +A A P + +L P Q+ + H P +PP
Sbjct: 776 QGSPTASQA-PNQPQAPTAPVPHTHIQQAPALHP--------QRPPSPHPPPHPSP-HPP 825
Query: 653 -------------PSHPQRTFY---PHHPQMLGFDPRWMM----MPSYMDPRITPTRTPV 692
PSH Q + P P L P P + P+ + + P+
Sbjct: 826 LQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPL 885
Query: 693 DFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMAL 752
P+A +P ++ Q +L E PL + P PP A
Sbjct: 886 GTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKP---PPTTPIPQLPAP 942
Query: 753 QSKGYPLPHPKSSDTLAMDMRVRNESSFS--ASLGRAGGVSAQRDLFEERGEEYLSAFDK 810
Q+ +P PH +M+ + + +SL SA + + S
Sbjct: 943 QAHKHP-PHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ---SQPLP 998
Query: 811 KAQADFDSCISSQRI----------GQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFV 860
+ A SQ + G + P Q PGG P+ P
Sbjct: 999 SSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPP------PITPPTC 1052
Query: 861 PDEKKPECGSWDVSHQPETADTAHGVE----RETPREGTAFNISSWDKNGSPNKQPSSEP 916
P P G + P + A G P + D P P
Sbjct: 1053 PSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPR 1112
Query: 917 EWTPEPRS-SSSQHPEQTGR-----------TRRSGPIKKPVLKALKVEDKEKELEKIKQ 964
+PEP + H Q+ R R+ P+ + + +E+ +EK K+
Sbjct: 1113 SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKR 1172
Query: 965 ELGEESTR-LAKEKEQSPTAEKDEDEENDASLANSSTTTLED--------KGPGHATFGR 1015
E +++ +EKE+ E++ + E +A A ++++ + GPGH
Sbjct: 1173 EAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMR--- 1229
Query: 1016 EATKFEEEEKPDKAWEARPPRESSDVPPMK 1045
E P A PP D P ++
Sbjct: 1230 -----PSFEPPPTTIAAVPPYIGPDTPALR 1254
>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 58.5 bits (140), Expect = 7e-08
Identities = 154/684 (22%), Positives = 231/684 (33%), Gaps = 97/684 (14%)
Query: 1588 PVKGR--GLSSRIPPRFAKKQNNLC-LEQGDVTVPGSSLG-----TEIWESSSQALPVQA 1639
PVK GLS + R + + ++ L G P S G E SS + P A
Sbjct: 558 PVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAA 617
Query: 1640 P--ANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLK 1697
+NDS + V + A KS++ +++++ E+ TSS+++ +
Sbjct: 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE-KVASDTEEADRTSSKKTKTQEISR 676
Query: 1698 PEEMS-GPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEG 1756
P S G G +DS S+ KD +Q + + P P NE
Sbjct: 677 PNSPSEGEG---ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD-----SDSS 728
Query: 1757 AERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSP------V 1810
A++ PP L P GV+P S S PPG+ PT P V
Sbjct: 729 AQQQMLQAQPPA----------LQAPT---GVTPAPS--SAPPGTPQLPTPGPTPSATAV 773
Query: 1811 VKLQDALASNAGLTQSIPILRRDH-HIQRAIGLSPMSFPTADLTLKME-----SARKAWE 1864
AS A P H HIQ+A L P P+
Sbjct: 774 PPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833
Query: 1865 NSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSS----FGGVSMPPMPVASVAPSASMPG 1920
PS P + P G G P S+ A + + FG +PP AP + P
Sbjct: 834 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFG---LPPQASQGQAPLGTSPA 890
Query: 1921 SHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLP 1980
+ P L + ASQ L Q P++Q A A T+ Q LP
Sbjct: 891 AAYPHTSLQ--LPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQ--------LP 940
Query: 1981 VSQSQEI---FSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQ 2037
Q+ + S PF + P PP+ LS + PP + P +Q + +P
Sbjct: 941 APQAHKHPPHLSGPSPFSMNANLPP---PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPL 997
Query: 2038 SGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQ 2097
SP QP Q+ + G Q+ P P + Q P +
Sbjct: 998 PSSPAQPPGLTQSQNLPPPPASHPPTGLHQV---------APQPPF--AQHPFVPGGPPP 1046
Query: 2098 LPPGQSLSVGAPRRIPPPGSQPPVLNTSREPS-------------QMEMKGFHFADSKQN 2144
+ P S P P +QPP + Q++ + A+ ++
Sbjct: 1047 ITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPES 1106
Query: 2145 VPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEA 2204
P PSP+ P+ S SA + Y A+ + P G+ ++
Sbjct: 1107 PPPPPRSPSPE---PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKR 1163
Query: 2205 PSAASQMKRTGAIKPRAVKVEESK 2228
A + KR K R + E +
Sbjct: 1164 EEAIEKAKREAEQKAREEREREKE 1187
Score = 40.4 bits (93), Expect = 0.020
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 18/118 (15%)
Query: 495 IQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVP 554
+ + EA+E+A++ E E++AREER ++ +K K+ + E ++AE+
Sbjct: 1159 LAKKREEAIEKAKR---EAEQKAREER--------EREKEKEKEREREREREREAERAAK 1207
Query: 555 WSPSAEK---ASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAR 609
S SA + + PQ +GP + S E P PTT P + P + E AR
Sbjct: 1208 ASSSAHEGRLSDPQLSGPGHMRPSFEPP----PTTIAAVPPYIGPDTPALRTLSEYAR 1261
Score = 38.1 bits (87), Expect = 0.097
Identities = 109/570 (19%), Positives = 183/570 (32%), Gaps = 92/570 (16%)
Query: 533 DQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAP 592
D + A + QA+ +P+ +P P G+P+ P + P
Sbjct: 720 DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP----GTPQLPTPGPTPSATAVPP 775
Query: 593 TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP 652
SP +Q+ ++ +A A P + +L P Q+ + H P +PP
Sbjct: 776 QGSPTASQA-PNQPQAPTAPVPHTHIQQAPALHP--------QRPPSPHPPPHPSP-HPP 825
Query: 653 -------------PSHPQRTFY---PHHPQMLGFDPRWMM----MPSYMDPRITPTRTPV 692
PSH Q + P P L P P + P+ + + P+
Sbjct: 826 LQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPL 885
Query: 693 DFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMAL 752
P+A +P ++ Q +L E PL + P PP A
Sbjct: 886 GTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKP---PPTTPIPQLPAP 942
Query: 753 QSKGYPLPHPKSSDTLAMDMRVRNESSFS--ASLGRAGGVSAQRDLFEERGEEYLSAFDK 810
Q+ +P PH +M+ + + +SL SA + + S
Sbjct: 943 QAHKHP-PHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ---SQPLP 998
Query: 811 KAQADFDSCISSQRI----------GQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFV 860
+ A SQ + G + P Q PGG P+ P
Sbjct: 999 SSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPP------PITPPTC 1052
Query: 861 PDEKKPECGSWDVSHQPETADTAHGVE----RETPREGTAFNISSWDKNGSPNKQPSSEP 916
P P G + P + A G P + D P P
Sbjct: 1053 PSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPR 1112
Query: 917 EWTPEPRS-SSSQHPEQTGR-----------TRRSGPIKKPVLKALKVEDKEKELEKIKQ 964
+PEP + H Q+ R R+ P+ + + +E+ +EK K+
Sbjct: 1113 SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKR 1172
Query: 965 ELGEESTR-LAKEKEQSPTAEKDEDEENDASLANSSTTTLED--------KGPGHATFGR 1015
E +++ +EKE+ E++ + E +A A ++++ + GPGH
Sbjct: 1173 EAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMR--- 1229
Query: 1016 EATKFEEEEKPDKAWEARPPRESSDVPPMK 1045
E P A PP D P ++
Sbjct: 1230 -----PSFEPPPTTIAAVPPYIGPDTPALR 1254
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 57.0 bits (136), Expect = 2e-07
Identities = 143/670 (21%), Positives = 239/670 (35%), Gaps = 150/670 (22%)
Query: 469 KSSMGSMFRQQSIEDKEDKPPP---------RQKFIQSEMSEAVERARKRREEEERRARE 519
KS+ ++ +QQ ++ ++ + P RQ+ I+ + E R+R EE++RR RE
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEE-----RRRVEEQQRRERE 417
Query: 520 ERLAACAAKLKQLDQKCK----QARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGS 575
+R KL++ +Q+ + QA + E R+QAE+E
Sbjct: 418 QR------KLQEKEQQRRLEDMQALRREEERRQAERE----------------------- 448
Query: 576 PEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQ 635
E+ ++ + + SE R+ QE Y KSL + Q+QQ Q+
Sbjct: 449 QEYKRKQ---------------LEEQRQSERLQRQL---QQEHAYLKSLQQQQQQQQLQK 490
Query: 636 QQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPV-DF 694
QQ+Q +P+Y H R P P W +P+
Sbjct: 491 QQQQQLLPGDRKPLY----HYGRGMNP------ADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 695 YPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQS 754
P + P +P +PQ S G S+ PP+Q R V P + P + L+
Sbjct: 541 KPGSTGP----EPPIPQASPGPPGPLSQ----TPPMQ-RPVEPQEGPHKSLVAHRVPLKP 591
Query: 755 KGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQA 814
P+P +S D RN ++F AS + A RG D ++
Sbjct: 592 YAAPVPRSQS----LQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEG 647
Query: 815 DFDSCISSQRIGQELLFPPQ---------ENVQDAGAPGGH-TQNLRCSPLEPDFVPDEK 864
S + + PP+ + +GA G Q +R S PD +
Sbjct: 648 PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASN------PDLR 701
Query: 865 KPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNG-SPNKQPSSEPEWTPEPR 923
+ + G W+ S A H P+ G S ++N + +P S P +P +
Sbjct: 702 RSDPG-WERSDSVLPASHGH-----LPQAG------SLERNRVGVSSKPDSSPVLSPGNK 749
Query: 924 SSSSQHPEQTGR--------TRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAK 975
+ H + GR R +P KA+ +E+E + + E A+
Sbjct: 750 AKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAE 809
Query: 976 EKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK---------- 1025
+P D D ++ +++ + P + + EEE+
Sbjct: 810 GSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGY 869
Query: 1026 ---PDKAWEARPPRESS--DVPPMKRNNWIFIDEEQAFGVRGQARGRGR-GFREFTFRG- 1078
PD + P E+S PP K D + RG + G+ F F G
Sbjct: 870 TNLPDVVQPSHSPTENSKGQSPPSK-------DGSGDYQSRGLVKAPGKSSFTMFVDLGI 922
Query: 1079 RPAGGNGSGL 1088
GG+G +
Sbjct: 923 YQPGGSGDSI 932
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 54.3 bits (129), Expect = 1e-06
Identities = 115/589 (19%), Positives = 207/589 (35%), Gaps = 59/589 (10%)
Query: 481 IEDKEDKPPPRQKFIQSEMSEAVERARKRRE---EEERRAREERLAA-----CAAKLKQL 532
+E++ ++ ++ + E EA E K E EEE EE + A+ K+
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516
Query: 533 DQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKG-------SPEFPAQETPT 585
K+ K+ K EKE SP+ K+ + PA + SPE ++P
Sbjct: 517 KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA 576
Query: 586 TF--PEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKM 643
PE+A + + A+S + + +A SP +E + +++ + E
Sbjct: 577 EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE 636
Query: 644 QHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSG 703
+ P P++ P + P P + + +P + A P
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEE--AKSPEKAKSPVKAEAK-SPEKAKSPVKAEAKSPEK 693
Query: 704 LMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPV----WSPEGYMALQSKGYPL 759
P+ + +S ++ P +E K PV +PE + +
Sbjct: 694 AKSPVKEE-------AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 760 PHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSC 819
P S A + V++ + + + A + D F E+ + + + K+ S
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKTPAKEEA---RSPADKFPEKAKSPVKE-EVKSPEKAKSP 802
Query: 820 ISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPET 879
+ E P +E V+ Q ++ P +EK P P+T
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE-PPKKAEEEKAPA--------TPKT 853
Query: 880 ADTAHGVERETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRS 939
+ + E P++ + P + EP +P+ S + ++ ++
Sbjct: 854 EEKKDSKKEEAPKK----------EAPKPKVEEKKEPA-VEKPKESKVEAKKEEAEDKKK 902
Query: 940 GPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSS 999
P + A KVE KE K K E+ ++ AK KE S AEK E
Sbjct: 903 VPTPEKEAPA-KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEK 961
Query: 1000 TTTLEDKGPGHATFGR-EATKFEEEEKP--DKAWEARPPRESSDVPPMK 1045
E+K A + T +E KP +KA ++ + PP K
Sbjct: 962 AKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 49.3 bits (116), Expect = 4e-05
Identities = 58/259 (22%), Positives = 105/259 (40%), Gaps = 17/259 (6%)
Query: 388 SDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRT--REEGKDWAEAVGASRVV 445
S E + V ++ + P + + + A S + ++ +EE K +A +
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 446 RKAPDPQPPPRKLHGWAP--GPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAV 503
K+P+ P K +P K S + +S +E K P + K E ++
Sbjct: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 504 ERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAG--EARKQAEK--EVPWSPSA 559
E+A+ +EE A+ A K K LD K +A+ EAR A+K E SP
Sbjct: 734 EKAKSPVKEE---AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
Query: 560 EKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFK 619
E+ E + K + P +E P++ SP + E + +E A+E K
Sbjct: 791 EEVKSPEKAKSPLKEDAKAPEKE----IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
Query: 620 YQKSLPPRFQRQQQQQQQE 638
+ P+ + ++ +++E
Sbjct: 847 APAT--PKTEEKKDSKKEE 863
Score = 46.6 bits (109), Expect = 3e-04
Identities = 48/215 (22%), Positives = 89/215 (41%), Gaps = 23/215 (10%)
Query: 838 QDAGAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAF 897
++A +P ++ P V +K + + + + PE A + E ++P
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP------ 663
Query: 898 NISSWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEK 957
+K SP K + PE P + ++ PE+ ++ K P V+++ K
Sbjct: 664 -----EKAKSPVKAEAKSPEKAKSPVKAEAKSPEKA-KSPVKEEAKSPEKAKSPVKEEAK 717
Query: 958 ELEKIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGRE- 1016
EK K + EE AK E++ + K+E + + + + TL+ K P T +E
Sbjct: 718 SPEKAKSPVKEE----AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 1017 ----ATKFEEEEKPDKAWEARPPRESSDVPPMKRN 1047
A KF E+ K E + P ++ P+K +
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEKAKS--PLKED 806
Score = 44.7 bits (104), Expect = 0.001
Identities = 116/624 (18%), Positives = 217/624 (34%), Gaps = 99/624 (15%)
Query: 374 GLHEEVDYSEKLKFSDDEEEEEVVKDGR-PKWNSWDPRRQRQLSMSSADSADAKRTRE-- 430
G EE E+ + ++E + ++ P+ + P ++ S + A S + + +
Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 431 EGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPP 490
E K +A ++ K+P P K +P + + S + +S +E K P
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP------AEVKSPEKAKSPAKEEAKSPA 596
Query: 491 RQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAE 550
K + S E A+ E + E + A ++ K+ K+ E K E
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 551 KEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEE--EA 608
KE SP K+ + + K P +A SP A+S EE
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKS-----------PVKAEAKSPEKAKSPVKEEAKSP 705
Query: 609 REAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQML 668
+A SP +E ++ P + +++ + K + PV P++ P + L
Sbjct: 706 EKAKSPVKE----EAKSPEKAKSPVKEEAKTPEKAK--SPVKEEAKSPEKAKSPEKAKTL 759
Query: 669 GFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVP 728
+ P P R+P D +P + P+++ +
Sbjct: 760 D-----VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS------------- 801
Query: 729 PLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAG 788
PL+E P P K + P + +++V+ E A +A
Sbjct: 802 PLKEDAKAPEKEIP------------KKEEVKSPVKEEEKPQEVKVK-EPPKKAEEEKAP 848
Query: 789 GVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQ 848
+ + + EE A K+A P+ V++ P
Sbjct: 849 ATPKTEEKKDSKKEE---APKKEA--------------------PKPKVEEKKEPAVEKP 885
Query: 849 NLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSP 908
+ + D+KK + + E + A P+E T ++ + + +
Sbjct: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA------KPKEKT--EVAKKEPDDAK 937
Query: 909 NKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKE---KELEKIKQE 965
K+PS P + ++ + T + P +KP +A ED + KE K K E
Sbjct: 938 AKEPSK-----PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992
Query: 966 LGEESTRLAKEKEQSPTAEKDEDE 989
E+S+ +K+ P + ED+
Sbjct: 993 KAEKSSS-TDQKDSKPPEKATEDK 1015
Score = 40.8 bits (94), Expect = 0.015
Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 27/197 (13%)
Query: 861 PDEKKPECGSWDVSHQ---PETA-----DTAHGVERETPREGTAFNISSWDKNGSPNKQP 912
P +K PE V + PE A + A E+E P++ S + P +
Sbjct: 777 PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK--SPVKEEEKPQEVK 834
Query: 913 SSEP-EWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEEST 971
EP + E ++ ++ E+ +++ KK K E KE +EK K+ E
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKK 894
Query: 972 RLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEKPD-KAW 1030
A++K++ PT EK+ A + ED P +E T+ ++E D KA
Sbjct: 895 EEAEDKKKVPTPEKE---------APAKVEVKEDAKP------KEKTEVAKKEPDDAKAK 939
Query: 1031 EARPPRESSDVPPMKRN 1047
E P E + P K++
Sbjct: 940 EPSKPAEKKEAAPEKKD 956
Score = 37.7 bits (86), Expect = 0.13
Identities = 80/436 (18%), Positives = 144/436 (33%), Gaps = 32/436 (7%)
Query: 1368 DHANEEWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPV 1427
+ EE + E ++ E +E +E G E + + G K A+ + S ++
Sbjct: 458 EEQTEETQVTEEVTE-EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516
Query: 1428 VDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSG 1487
+ + + P E ++ +P +VK P S
Sbjct: 517 KSPVKEEAKSPAEAKSP------------EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 1488 HSPYALERAAHASADLPEASSKKAEKEAKLAA----PRAGEQGEAMKQFDLNYGSAIIEN 1543
SP E + A PE + A++EAK A P + + + ++
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 1544 CGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFA 1603
SP E E + ++ + E+E K + + PVK S P A
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS----PEKA 680
Query: 1604 K---KQNNLCLEQGDVTVPGSSLGTE-----IWESSSQALPVQAPANDSWRKAVTAFSST 1655
K K E+ V + E + E + ++P + + A S
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740
Query: 1656 ETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHK 1715
+ A+ K+ + L +S E+ + + + PE+ P E K+ K
Sbjct: 741 KE-EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKS-PEK 798
Query: 1716 EQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHV 1775
++P + K E+ KE P+ E + K E ++ + P E
Sbjct: 799 AKSPLKEDAKAPEK-EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 1776 DSVLPVPPIEFGVSPK 1791
DS P + PK
Sbjct: 858 DSKKEEAPKKEAPKPK 873
Score = 31.6 bits (70), Expect = 9.1
Identities = 33/133 (24%), Positives = 59/133 (44%), Gaps = 15/133 (11%)
Query: 912 PSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEEST 971
P S PE P+ S S+ ++ + ++K + + VE++ +E + + +E+ EE
Sbjct: 419 PFSLPEGLPKIPSVSTHIKVKS--EEKIKVVEKSEKETVIVEEQTEETQ-VTEEVTEEEE 475
Query: 972 RLAKEKE-------QSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEE 1024
+ AKE+E + AE E+E +++ E K P +E K E
Sbjct: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP-----VKEEAKSPAEA 530
Query: 1025 KPDKAWEARPPRE 1037
K + EA+ P E
Sbjct: 531 KSPEKEEAKSPAE 543
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 54.3 bits (129), Expect = 1e-06
Identities = 59/249 (23%), Positives = 95/249 (38%), Gaps = 11/249 (4%)
Query: 374 GLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGK 433
G EE + E K SD EE K+G + + + + + A+AK ++ +
Sbjct: 532 GQEEEEEEDEGAK-SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 434 DWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMG-SMFRQQSIEDKEDKPPPRQ 492
E +V A +P K +P P G S + +E+K P P+
Sbjct: 591 KSEEVATKEELVADAKVEKPEKAK----SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 493 KFIQSEMSEAVERA--RKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAE 550
+ S + K + + EE+ + K + K K GE +++ E
Sbjct: 647 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 706
Query: 551 KEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEARE 610
KEV +P EK +E P K PE E+P A V+ + E+E +E
Sbjct: 707 KEVKEAPKEEKVEKKEEKP---KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763
Query: 611 AGSPAQEFK 619
G P Q+ K
Sbjct: 764 EGKPLQQEK 772
Score = 44.7 bits (104), Expect = 0.001
Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 10/126 (7%)
Query: 924 SSSSQHPE-QTGRTRRSGPIKKPVLKALKVEDKEKELEK----IKQELG----EESTRLA 974
SS Q P+ + + + + +++ KVED++ E+E+ I +EL EE A
Sbjct: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAA 492
Query: 975 KEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEE-EKPDKAWEAR 1033
+EKE+ P AE++E + + ++ E++G G+E + E+E K D+A E
Sbjct: 493 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 552
Query: 1034 PPRESS 1039
+E S
Sbjct: 553 SEKEGS 558
Score = 41.2 bits (95), Expect = 0.011
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 32/276 (11%)
Query: 1501 ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGE 1560
A PE ++ EKE + E+ E K G + E GSS EE E E
Sbjct: 515 ATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS--EKEGSSEKEEGE----QEE 568
Query: 1561 GFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG 1620
G E + + +EE++ +E++ +V K ++ AK + E+ VP
Sbjct: 569 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD------AKVEKP---EKAKSPVPK 619
Query: 1621 SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESR 1680
S + E ++ ++P + + V E G + + +S
Sbjct: 620 SPV-----EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 674
Query: 1681 ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPG 1740
E A S SP K + G G E K + KE P E+K + KE +P
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKG--EQKEEEEKEVKEAPKEEK------VEKKEEKPK 726
Query: 1741 PIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVD 1776
+ K + S E VV V++H++
Sbjct: 727 DVPE----KKKAESPVKEEAVAEVVTITKSVKVHLE 758
Score = 37.4 bits (85), Expect = 0.17
Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 9/151 (5%)
Query: 462 APGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKR---REEEERRAR 518
AP Q + + + +ED++ + I E++ +++ +K +EEE A
Sbjct: 443 APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAE 502
Query: 519 EERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEF 578
EE +AA + +K + K+ E + E+E A K+ E G + +GS E
Sbjct: 503 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA-KSDQAEEGGSEKEGSSEK 561
Query: 579 PAQETPTTFPEEAPTVSPAVAQSNSSEEEAR 609
E EE T + A + ++EE +
Sbjct: 562 EEGE-----QEEGETEAEAEGEEAEAKEEKK 587
Score = 36.6 bits (83), Expect = 0.28
Identities = 54/285 (18%), Positives = 110/285 (38%), Gaps = 49/285 (17%)
Query: 386 KFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVV 445
KF ++ EE V+D + + +L++S + + K EE ++ EA
Sbjct: 451 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE--EKKEAAEEKEEEPEAEEEEVAA 508
Query: 446 RKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVER 505
+K+P P K G ++ E++E++ ++ +A E
Sbjct: 509 KKSPVKATAPEV-----------KEEEGEKEEEEGQEEEEEEDEG------AKSDQAEEG 551
Query: 506 ARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQ----------------- 548
++ E+ E+ A+ + + + K+ +K E ++
Sbjct: 552 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 611
Query: 549 -AEKEVPWSPSAEKA-SPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSS-- 604
A+ VP SP EK SP P KG + P ++P ++P V + S
Sbjct: 612 KAKSPVPKSPVEEKGKSPVPKSPVEEKG--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 669
Query: 605 -----EEEARE--AGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYK 642
EE+A+ SP +E K + + Q+++++++ ++ K
Sbjct: 670 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 714
Score = 36.6 bits (83), Expect = 0.28
Identities = 64/271 (23%), Positives = 102/271 (37%), Gaps = 38/271 (14%)
Query: 798 EERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEP 857
EE G+E D+ A++D S++ G +E Q+ G + E
Sbjct: 529 EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS---EKEEGEQEEGETEAEAEG------EE 579
Query: 858 DFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSP-NKQPSSEP 916
+EKK E S +V+ + E A VE+ + +K SP K P E
Sbjct: 580 AEAKEEKKVEEKSEEVATKEELVADAK-VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 638
Query: 917 EWTPEPRS-----SSSQHPEQTGRTRRSGPIKK--------------PVLKAL------K 951
+P P+S S P+ + P+ K PV +A K
Sbjct: 639 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 698
Query: 952 VEDKEKELEKIKQELGEESTRLAKEKEQS-PTAEKDEDEENDASLANSSTTTLEDKGPGH 1010
E KE+E +++K+ EE +EK + P +K E + ++A T T K
Sbjct: 699 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 758
Query: 1011 ATFGREATKFEEEEKPDKA-WEARPPRESSD 1040
E ++E++ +KA E E SD
Sbjct: 759 KETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 789
Score = 32.0 bits (71), Expect = 7.0
Identities = 32/134 (23%), Positives = 53/134 (39%), Gaps = 14/134 (10%)
Query: 921 EPRSSSSQHPEQTGRTRRSGPIKKPVLKA----LKVEDKEKELEKIKQELGEESTRLAKE 976
E + ++ + E+ KK +KA +K E+ EKE E+ ++E EE +
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546
Query: 977 KEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEE--------EEKPDK 1028
+ + +EK+ E + T E + G +E K EE EE
Sbjct: 547 QAEEGGSEKEGSSEKEEGEQEEGET--EAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 604
Query: 1029 AWEARPPRESSDVP 1042
A +P + S VP
Sbjct: 605 AKVEKPEKAKSPVP 618
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 54.3 bits (129), Expect = 1e-06
Identities = 59/249 (23%), Positives = 95/249 (38%), Gaps = 11/249 (4%)
Query: 374 GLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGK 433
G EE + E K SD EE K+G + + + + + A+AK ++ +
Sbjct: 156 GQEEEEEEDEGAK-SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
Query: 434 DWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMG-SMFRQQSIEDKEDKPPPRQ 492
E +V A +P K +P P G S + +E+K P P+
Sbjct: 215 KSEEVATKEELVADAKVEKPEKAK----SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
Query: 493 KFIQSEMSEAVERA--RKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAE 550
+ S + K + + EE+ + K + K K GE +++ E
Sbjct: 271 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 330
Query: 551 KEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEARE 610
KEV +P EK +E P K PE E+P A V+ + E+E +E
Sbjct: 331 KEVKEAPKEEKVEKKEEKP---KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
Query: 611 AGSPAQEFK 619
G P Q+ K
Sbjct: 388 EGKPLQQEK 396
Score = 44.7 bits (104), Expect = 0.001
Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 10/126 (7%)
Query: 924 SSSSQHPE-QTGRTRRSGPIKKPVLKALKVEDKEKELEK----IKQELG----EESTRLA 974
SS Q P+ + + + + +++ KVED++ E+E+ I +EL EE A
Sbjct: 57 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAA 116
Query: 975 KEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEE-EKPDKAWEAR 1033
+EKE+ P AE++E + + ++ E++G G+E + E+E K D+A E
Sbjct: 117 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 176
Query: 1034 PPRESS 1039
+E S
Sbjct: 177 SEKEGS 182
Score = 41.2 bits (95), Expect = 0.011
Identities = 62/276 (22%), Positives = 101/276 (36%), Gaps = 32/276 (11%)
Query: 1501 ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGE 1560
A PE ++ EKE + E+ E K G + E GSS EE E E
Sbjct: 139 ATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS--EKEGSSEKEEGE----QEE 192
Query: 1561 GFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPG 1620
G E + + +EE++ +E++ +V K ++ AK + E+ VP
Sbjct: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD------AKVEKP---EKAKSPVPK 243
Query: 1621 SSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESR 1680
S + E ++ ++P + + V E G + + +S
Sbjct: 244 SPV-----EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
Query: 1681 ESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPG 1740
E A S SP K + G G E K + KE P E+K + KE +P
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKG--EQKEEEEKEVKEAPKEEK------VEKKEEKPK 350
Query: 1741 PIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVD 1776
+ K + S E VV V++H++
Sbjct: 351 DVPE----KKKAESPVKEEAVAEVVTITKSVKVHLE 382
Score = 37.4 bits (85), Expect = 0.17
Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 9/151 (5%)
Query: 462 APGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKR---REEEERRAR 518
AP Q + + + +ED++ + I E++ +++ +K +EEE A
Sbjct: 67 APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAE 126
Query: 519 EERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEF 578
EE +AA + +K + K+ E + E+E A K+ E G + +GS E
Sbjct: 127 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA-KSDQAEEGGSEKEGSSEK 185
Query: 579 PAQETPTTFPEEAPTVSPAVAQSNSSEEEAR 609
E EE T + A + ++EE +
Sbjct: 186 EEGE-----QEEGETEAEAEGEEAEAKEEKK 211
Score = 36.6 bits (83), Expect = 0.28
Identities = 54/285 (18%), Positives = 110/285 (38%), Gaps = 49/285 (17%)
Query: 386 KFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVV 445
KF ++ EE V+D + + +L++S + + K EE ++ EA
Sbjct: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE--EKKEAAEEKEEEPEAEEEEVAA 132
Query: 446 RKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVER 505
+K+P P K G ++ E++E++ ++ +A E
Sbjct: 133 KKSPVKATAPEV-----------KEEEGEKEEEEGQEEEEEEDEG------AKSDQAEEG 175
Query: 506 ARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQ----------------- 548
++ E+ E+ A+ + + + K+ +K E ++
Sbjct: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 549 -AEKEVPWSPSAEKA-SPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSS-- 604
A+ VP SP EK SP P KG + P ++P ++P V + S
Sbjct: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKG--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 293
Query: 605 -----EEEARE--AGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYK 642
EE+A+ SP +E K + + Q+++++++ ++ K
Sbjct: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 338
Score = 36.6 bits (83), Expect = 0.28
Identities = 64/271 (23%), Positives = 102/271 (37%), Gaps = 38/271 (14%)
Query: 798 EERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEP 857
EE G+E D+ A++D S++ G +E Q+ G + E
Sbjct: 153 EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS---EKEEGEQEEGETEAEAEG------EE 203
Query: 858 DFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSP-NKQPSSEP 916
+EKK E S +V+ + E A VE+ + +K SP K P E
Sbjct: 204 AEAKEEKKVEEKSEEVATKEELVADAK-VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
Query: 917 EWTPEPRS-----SSSQHPEQTGRTRRSGPIKK--------------PVLKAL------K 951
+P P+S S P+ + P+ K PV +A K
Sbjct: 263 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 322
Query: 952 VEDKEKELEKIKQELGEESTRLAKEKEQS-PTAEKDEDEENDASLANSSTTTLEDKGPGH 1010
E KE+E +++K+ EE +EK + P +K E + ++A T T K
Sbjct: 323 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 382
Query: 1011 ATFGREATKFEEEEKPDKA-WEARPPRESSD 1040
E ++E++ +KA E E SD
Sbjct: 383 KETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 413
Score = 32.0 bits (71), Expect = 7.0
Identities = 32/134 (23%), Positives = 53/134 (39%), Gaps = 14/134 (10%)
Query: 921 EPRSSSSQHPEQTGRTRRSGPIKKPVLKA----LKVEDKEKELEKIKQELGEESTRLAKE 976
E + ++ + E+ KK +KA +K E+ EKE E+ ++E EE +
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 977 KEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEE--------EEKPDK 1028
+ + +EK+ E + T E + G +E K EE EE
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGET--EAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 228
Query: 1029 AWEARPPRESSDVP 1042
A +P + S VP
Sbjct: 229 AKVEKPEKAKSPVP 242
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 54.3 bits (129), Expect = 1e-06
Identities = 177/937 (18%), Positives = 297/937 (31%), Gaps = 108/937 (11%)
Query: 1376 TASESSDFSERRERREGPGSEPDSQVDGGLSGASL---------GEKKELAKRSFSSQRP 1426
+ SESS+ E E + + + + GA L E ++ K S P
Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
Query: 1427 VVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSS-- 1484
+ L G K P T ++ P + + G + SS
Sbjct: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 1485 --GSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIE 1542
S + + A + +S E A+ AAP G+ G+ Q + G+
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPA 260
Query: 1543 NCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKG---RGLSSRIP 1599
P EESE E E + ++ E+ + +A P KG +G + P
Sbjct: 261 KRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320
Query: 1600 --------------PRFAKKQNNLCLEQGDVTVPGSS--LGTEIWESSSQALPVQAPAND 1643
P + ++ + P + L + +SQ APA +
Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380
Query: 1644 SWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG 1703
S RK +TG A ++ + + S+E +S + ++ P G +
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 1704 PGLAEPKADSHKEQAPKPSEQKDSEQGSGQ-SKEHRPGPIGNERSLKNRKGSEGAERLQG 1762
A K K AP P + Q K+ +E S +R E +
Sbjct: 441 ---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR---EALAAMNA 494
Query: 1763 AVVPPV-NGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSPVVKL--QDALAS 1819
A V P+ ++ S + + P+ G P +PPG T S V +D+ +S
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGP------VPPGKVGPATPSAQVGKWEEDSESS 548
Query: 1820 NAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTL-KMESARKAWENSPSLPEQSSPGGA 1878
+ + S D + A+ P + +L + A+ + P+++ P
Sbjct: 549 SEESSDS-----SDGEVPTAVA------PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAV 597
Query: 1879 GSGIQPPSSVGASSGVNYSSFGGVSMP-PMPVASVAPSASMPGSHLPPLYLDG------- 1930
+ P SS + S P M A P+ +P + P +
Sbjct: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 657
Query: 1931 --HVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVS--QSQE 1986
V PR S A Q P +S + + GL V+ Q++
Sbjct: 658 PVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKS 717
Query: 1987 IFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMS 2046
+ LQ + V + SL + +L G T + E + +S S S
Sbjct: 718 VGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAAS 777
Query: 2047 GNQALV----YEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQ 2102
Q + + + AA S P + + P + ++ P
Sbjct: 778 PAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNS 837
Query: 2103 SLSVGAPRRIPPPGSQPPVL-----------NTSREPSQMEMKGFHFADSK--------- 2142
++ P +P G +S E S E + A K
Sbjct: 838 TVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
Query: 2143 ------QNVPSGGPVPSPQTYRPSSASPSGK--PSGSAVNMGSVQGHYVQQAKQRVDEKP 2194
+ P G P+P SA+ +GK SGS+ G KP
Sbjct: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Query: 2195 SLGAVKLQEAPS--AASQMKRTGAIKPRAVKVEESKA 2229
L V +P+ AA+ + A PR + ES A
Sbjct: 958 PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTA 994
Score = 37.0 bits (84), Expect = 0.22
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 13/162 (8%)
Query: 488 PPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARK 547
PP + + S+ EE EE A A L QA+ +G+ +
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL--------QAKASGKTSQ 370
Query: 548 QAEKEVPWSPSAEK----ASPQENGPAVHKGSPEFPAQETPTTFPE-EAPTVSPAVAQSN 602
P S K A P + GPAV K +++ ++ E ++ +PA A+ +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 603 SSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQ 644
+ R A +PA+E + + P ++ Q Q+ K +
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
Score = 35.0 bits (79), Expect = 0.82
Identities = 46/239 (19%), Positives = 81/239 (33%), Gaps = 21/239 (8%)
Query: 388 SDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRK 447
S+ EE ++ P + ++ A SA AK T +G A
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA----------- 318
Query: 448 APDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERAR 507
PP K A K S + D E++ P + +Q++ S +
Sbjct: 319 ------PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 508 KRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQEN 567
+ R+ A K K + ++ +++ +E+ + +A P
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 568 GPAVHKGSPEFPAQETPTTFPEEAP--TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSL 624
P V S PA+E+P AP PA AQ ++E S + +++L
Sbjct: 433 APQVRAASA--PAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREAL 489
Score = 35.0 bits (79), Expect = 0.82
Identities = 91/427 (21%), Positives = 157/427 (36%), Gaps = 55/427 (12%)
Query: 1327 GPEEEPHLLAGQWPGR-PKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSE 1385
GP + G P P+ S GT R P+L + A E + + +SSD S
Sbjct: 1057 GPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS 1116
Query: 1386 -RRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFS-SQRPVVDRQSRKLEPGGF--G 1441
E EGP + L G + + L + + + S V S+ L G G
Sbjct: 1117 GSEEDGEGPQGAKSAHT---LVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1173
Query: 1442 EKPVRPGGGDTSPRYESQQN-GTPLKVKRSPD---EALPGGLSGCSSGSGHSPYALERAA 1497
P +P+ +S + + L K PD EA P +G S
Sbjct: 1174 LTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLS------------- 1220
Query: 1498 HASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENC---GSSPGEESEV 1554
P+ K+A R ++G Q + I C P E++V
Sbjct: 1221 ------PKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQV 1274
Query: 1555 GSMVGEGFIEVLTKKQRRLLE---EERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCL 1611
+ V + E+L ++++++++ E RK ++ + + G ++R PR KK+
Sbjct: 1275 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAAR-TPRSKKKKKLGAG 1333
Query: 1612 EQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDS 1671
E G+ +V T S +A +A + +K + S G+ ++ + Q
Sbjct: 1334 EGGEASVSPEKTST---TSKGKAKRDKASGDVKEKKGKGSLGS--QGAKDEPEEELQKGM 1388
Query: 1672 GVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGS 1731
G + E + S S K E+ + K K++ K + KDSE S
Sbjct: 1389 G---TVEGGDQSNPKS---------KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPS 1436
Query: 1732 GQSKEHR 1738
+ K+ +
Sbjct: 1437 QKKKKKK 1443
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 54.3 bits (129), Expect = 1e-06
Identities = 177/937 (18%), Positives = 297/937 (31%), Gaps = 108/937 (11%)
Query: 1376 TASESSDFSERRERREGPGSEPDSQVDGGLSGASL---------GEKKELAKRSFSSQRP 1426
+ SESS+ E E + + + + GA L E ++ K S P
Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
Query: 1427 VVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSS-- 1484
+ L G K P T ++ P + + G + SS
Sbjct: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 1485 --GSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIE 1542
S + + A + +S E A+ AAP G+ G+ Q + G+
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPA 260
Query: 1543 NCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKG---RGLSSRIP 1599
P EESE E E + ++ E+ + +A P KG +G + P
Sbjct: 261 KRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320
Query: 1600 --------------PRFAKKQNNLCLEQGDVTVPGSS--LGTEIWESSSQALPVQAPAND 1643
P + ++ + P + L + +SQ APA +
Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380
Query: 1644 SWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG 1703
S RK +TG A ++ + + S+E +S + ++ P G +
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 1704 PGLAEPKADSHKEQAPKPSEQKDSEQGSGQ-SKEHRPGPIGNERSLKNRKGSEGAERLQG 1762
A K K AP P + Q K+ +E S +R E +
Sbjct: 441 ---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR---EALAAMNA 494
Query: 1763 AVVPPV-NGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSPVVKL--QDALAS 1819
A V P+ ++ S + + P+ G P +PPG T S V +D+ +S
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGP------VPPGKVGPATPSAQVGKWEEDSESS 548
Query: 1820 NAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTL-KMESARKAWENSPSLPEQSSPGGA 1878
+ + S D + A+ P + +L + A+ + P+++ P
Sbjct: 549 SEESSDS-----SDGEVPTAVA------PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAV 597
Query: 1879 GSGIQPPSSVGASSGVNYSSFGGVSMP-PMPVASVAPSASMPGSHLPPLYLDG------- 1930
+ P SS + S P M A P+ +P + P +
Sbjct: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 657
Query: 1931 --HVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVS--QSQE 1986
V PR S A Q P +S + + GL V+ Q++
Sbjct: 658 PVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKS 717
Query: 1987 IFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMS 2046
+ LQ + V + SL + +L G T + E + +S S S
Sbjct: 718 VGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAAS 777
Query: 2047 GNQALV----YEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQ 2102
Q + + + AA S P + + P + ++ P
Sbjct: 778 PAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNS 837
Query: 2103 SLSVGAPRRIPPPGSQPPVL-----------NTSREPSQMEMKGFHFADSK--------- 2142
++ P +P G +S E S E + A K
Sbjct: 838 TVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
Query: 2143 ------QNVPSGGPVPSPQTYRPSSASPSGK--PSGSAVNMGSVQGHYVQQAKQRVDEKP 2194
+ P G P+P SA+ +GK SGS+ G KP
Sbjct: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Query: 2195 SLGAVKLQEAPS--AASQMKRTGAIKPRAVKVEESKA 2229
L V +P+ AA+ + A PR + ES A
Sbjct: 958 PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTA 994
Score = 37.0 bits (84), Expect = 0.22
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 13/162 (8%)
Query: 488 PPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARK 547
PP + + S+ EE EE A A L QA+ +G+ +
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL--------QAKASGKTSQ 370
Query: 548 QAEKEVPWSPSAEK----ASPQENGPAVHKGSPEFPAQETPTTFPE-EAPTVSPAVAQSN 602
P S K A P + GPAV K +++ ++ E ++ +PA A+ +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 603 SSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQ 644
+ R A +PA+E + + P ++ Q Q+ K +
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
Score = 35.0 bits (79), Expect = 0.82
Identities = 46/239 (19%), Positives = 81/239 (33%), Gaps = 21/239 (8%)
Query: 388 SDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRK 447
S+ EE ++ P + ++ A SA AK T +G A
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA----------- 318
Query: 448 APDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERAR 507
PP K A K S + D E++ P + +Q++ S +
Sbjct: 319 ------PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 508 KRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQEN 567
+ R+ A K K + ++ +++ +E+ + +A P
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 568 GPAVHKGSPEFPAQETPTTFPEEAP--TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSL 624
P V S PA+E+P AP PA AQ ++E S + +++L
Sbjct: 433 APQVRAASA--PAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREAL 489
Score = 34.3 bits (77), Expect = 1.4
Identities = 87/407 (21%), Positives = 148/407 (36%), Gaps = 49/407 (12%)
Query: 1343 PKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSE-RRERREGPGSEPDSQV 1401
P+ S GT R P+L + A E + + +SSD S E EGP +
Sbjct: 1112 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1171
Query: 1402 DGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQN 1461
G + +E A S S V QS G P +P+ +S +
Sbjct: 1172 LGPTPSRTETLVEETAAES-SEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPS 1230
Query: 1462 -GTPLKVKRSPD---EALPGGLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEAKL 1517
+ L K PD EA P +G S P+ K+A
Sbjct: 1231 VSSTLAAKDDPDGKQEAKPQQAAGMLS-------------------PKTGGKEAASGTTP 1271
Query: 1518 AAPRAGEQGEAMKQFDLNYGSAIIENC---GSSPGEESEVGSMVGEGFIEVLTKKQRRLL 1574
R ++G Q + I C P E++V + V + E+L +++++++
Sbjct: 1272 QKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1331
Query: 1575 E---EERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESS 1631
+ E RK ++ + + G ++R PR KK+ E G+ +V T S
Sbjct: 1332 DTTKESSRKGWESRKRKLSGDQPAAR-TPRSKKKKKLGAGEGGEASVSPEKTST---TSK 1387
Query: 1632 SQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSS 1691
+A +A + +K + S G+ ++ + Q G + E + S S
Sbjct: 1388 GKAKRDKASGDVKEKKGKGSLGS--QGAKDEPEEELQKGMG---TVEGGDQSNPKS---- 1438
Query: 1692 PYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHR 1738
K E+ + K K++ K + KDSE S + K+ +
Sbjct: 1439 -----KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1480
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 54.3 bits (129), Expect = 1e-06
Identities = 177/937 (18%), Positives = 297/937 (31%), Gaps = 108/937 (11%)
Query: 1376 TASESSDFSERRERREGPGSEPDSQVDGGLSGASL---------GEKKELAKRSFSSQRP 1426
+ SESS+ E E + + + + GA L E ++ K S P
Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
Query: 1427 VVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSS-- 1484
+ L G K P T ++ P + + G + SS
Sbjct: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 1485 --GSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIE 1542
S + + A + +S E A+ AAP G+ G+ Q + G+
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPA 260
Query: 1543 NCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKG---RGLSSRIP 1599
P EESE E E + ++ E+ + +A P KG +G + P
Sbjct: 261 KRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP 320
Query: 1600 --------------PRFAKKQNNLCLEQGDVTVPGSS--LGTEIWESSSQALPVQAPAND 1643
P + ++ + P + L + +SQ APA +
Sbjct: 321 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 380
Query: 1644 SWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG 1703
S RK +TG A ++ + + S+E +S + ++ P G +
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 1704 PGLAEPKADSHKEQAPKPSEQKDSEQGSGQ-SKEHRPGPIGNERSLKNRKGSEGAERLQG 1762
A K K AP P + Q K+ +E S +R E +
Sbjct: 441 ---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR---EALAAMNA 494
Query: 1763 AVVPPV-NGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSPVVKL--QDALAS 1819
A V P+ ++ S + + P+ G P +PPG T S V +D+ +S
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGP------VPPGKVGPATPSAQVGKWEEDSESS 548
Query: 1820 NAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTL-KMESARKAWENSPSLPEQSSPGGA 1878
+ + S D + A+ P + +L + A+ + P+++ P
Sbjct: 549 SEESSDS-----SDGEVPTAVA------PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAV 597
Query: 1879 GSGIQPPSSVGASSGVNYSSFGGVSMP-PMPVASVAPSASMPGSHLPPLYLDG------- 1930
+ P SS + S P M A P+ +P + P +
Sbjct: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 657
Query: 1931 --HVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVS--QSQE 1986
V PR S A Q P +S + + GL V+ Q++
Sbjct: 658 PVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKS 717
Query: 1987 IFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMS 2046
+ LQ + V + SL + +L G T + E + +S S S
Sbjct: 718 VGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAAS 777
Query: 2047 GNQALV----YEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQ 2102
Q + + + AA S P + + P + ++ P
Sbjct: 778 PAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNS 837
Query: 2103 SLSVGAPRRIPPPGSQPPVL-----------NTSREPSQMEMKGFHFADSK--------- 2142
++ P +P G +S E S E + A K
Sbjct: 838 TVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
Query: 2143 ------QNVPSGGPVPSPQTYRPSSASPSGK--PSGSAVNMGSVQGHYVQQAKQRVDEKP 2194
+ P G P+P SA+ +GK SGS+ G KP
Sbjct: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Query: 2195 SLGAVKLQEAPS--AASQMKRTGAIKPRAVKVEESKA 2229
L V +P+ AA+ + A PR + ES A
Sbjct: 958 PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTA 994
Score = 37.0 bits (84), Expect = 0.22
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 13/162 (8%)
Query: 488 PPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARK 547
PP + + S+ EE EE A A L QA+ +G+ +
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL--------QAKASGKTSQ 370
Query: 548 QAEKEVPWSPSAEK----ASPQENGPAVHKGSPEFPAQETPTTFPE-EAPTVSPAVAQSN 602
P S K A P + GPAV K +++ ++ E ++ +PA A+ +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 603 SSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQ 644
+ R A +PA+E + + P ++ Q Q+ K +
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
Score = 35.8 bits (81), Expect = 0.48
Identities = 91/424 (21%), Positives = 153/424 (36%), Gaps = 50/424 (11%)
Query: 1327 GPEEEPHLLAGQWPGR-PKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSE 1385
GP + G P P+ S GT R P+L + A E + + +SSD S
Sbjct: 1057 GPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS 1116
Query: 1386 -RRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGFGEKP 1444
E EGP + G + +E A S S V QS G P
Sbjct: 1117 GSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES-SEDDVVAPSQSLLSGYMTPGLTP 1175
Query: 1445 VRPGGGDTSPRYESQQN-GTPLKVKRSPD---EALPGGLSGCSSGSGHSPYALERAAHAS 1500
+P+ +S + + L K PD EA P +G S
Sbjct: 1176 ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLS---------------- 1219
Query: 1501 ADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENC---GSSPGEESEVGSM 1557
P+ K+A R ++G Q + I C P E++V +
Sbjct: 1220 ---PKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQAS 1276
Query: 1558 VGEGFIEVLTKKQRRLLE---EERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQG 1614
V + E+L ++++++++ E RK ++ + + G ++R PR KK+ E G
Sbjct: 1277 VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAAR-TPRSKKKKKLGAGEGG 1335
Query: 1615 DVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVD 1674
+ +V T S +A +A + +K + S G+ ++ + Q G
Sbjct: 1336 EASVSPEKTST---TSKGKAKRDKASGDVKEKKGKGSLGS--QGAKDEPEEELQKGMG-- 1388
Query: 1675 LSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQS 1734
+ E + S S K E+ + K K++ K + KDSE S +
Sbjct: 1389 -TVEGGDQSNPKS---------KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKK 1438
Query: 1735 KEHR 1738
K+ +
Sbjct: 1439 KKKK 1442
Score = 35.0 bits (79), Expect = 0.82
Identities = 46/239 (19%), Positives = 81/239 (33%), Gaps = 21/239 (8%)
Query: 388 SDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRK 447
S+ EE ++ P + ++ A SA AK T +G A
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA----------- 318
Query: 448 APDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERAR 507
PP K A K S + D E++ P + +Q++ S +
Sbjct: 319 ------PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 508 KRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQEN 567
+ R+ A K K + ++ +++ +E+ + +A P
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 568 GPAVHKGSPEFPAQETPTTFPEEAP--TVSPAVAQSNSSEEEAREAGSPAQEFKYQKSL 624
P V S PA+E+P AP PA AQ ++E S + +++L
Sbjct: 433 APQVRAASA--PAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREAL 489
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 53.9 bits (128), Expect = 2e-06
Identities = 143/678 (21%), Positives = 239/678 (35%), Gaps = 158/678 (23%)
Query: 469 KSSMGSMFRQQSIEDKEDKPPP---------RQKFIQSEMSEAVERARKRREEEERRARE 519
KS+ ++ +QQ ++ ++ + P RQ+ I+ + E R+R EE++RR RE
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEE-----RRRVEEQQRRERE 417
Query: 520 ERLAACAAKLKQLDQKCK----QARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGS 575
+R KL++ +Q+ + QA + E R+QAE+E
Sbjct: 418 QR------KLQEKEQQRRLEDMQALRREEERRQAERE----------------------- 448
Query: 576 PEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQ 635
E+ ++ + + SE R+ QE Y KSL + Q+QQ Q+
Sbjct: 449 QEYKRKQ---------------LEEQRQSERLQRQL---QQEHAYLKSLQQQQQQQQLQK 490
Query: 636 QQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPV-DF 694
QQ+Q +P+Y H R P P W +P+
Sbjct: 491 QQQQQLLPGDRKPLY----HYGRGMNP------ADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 695 YPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQS 754
P + P +P +PQ S G S+ PP+Q R V P + P + L+
Sbjct: 541 KPGSTGP----EPPIPQASPGPPGPLSQ----TPPMQ-RPVEPQEGPHKSLVAHRVPLKP 591
Query: 755 KGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQA 814
P+P +S D RN ++F AS + A RG D ++
Sbjct: 592 YAAPVPRSQS----LQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEG 647
Query: 815 DFDSCISSQRIGQELLFPPQ---------ENVQDAGAPGGH-TQNLRCSPLEPDFVPDEK 864
S + + PP+ + +GA G Q +R S PD +
Sbjct: 648 PGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASN------PDLR 701
Query: 865 KPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNG-SPNKQPSSEPEWTPEPR 923
+ + G W+ S A H P+ G S ++N + +P S P +P +
Sbjct: 702 RSDPG-WERSDSVLPASHGH-----LPQAG------SLERNRVGVSSKPDSSPVLSPGNK 749
Query: 924 SSSSQHPEQTGR----------------TRRSGPIKKPVLKALKVEDKEKELEKIKQELG 967
+ H + GR R +P KA+ +E+E + +
Sbjct: 750 AKPDDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEE 809
Query: 968 EESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK-- 1025
E A+ +P D D ++ +++ + P + + EEE+
Sbjct: 810 EGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNL 869
Query: 1026 -----------PDKAWEARPPRESS--DVPPMKRNNWIFIDEEQAFGVRGQARGRGR-GF 1071
PD + P E+S PP K D + RG + G+ F
Sbjct: 870 LHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK-------DGSGDYQSRGLVKAPGKSSF 922
Query: 1072 REFTFRG-RPAGGNGSGL 1088
F G GG+G +
Sbjct: 923 TMFVDLGIYQPGGSGDSI 940
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 53.9 bits (128), Expect = 2e-06
Identities = 104/479 (21%), Positives = 167/479 (34%), Gaps = 60/479 (12%)
Query: 224 STSPTELGSRNSSTGDGAPSSACTSDSKDPSLRP----AQPVRKGASQFMGNVYHPPTYH 279
S SP R+S++ G+ SS+ +S S+ P +P + P RK + + P H
Sbjct: 341 SRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRK-TRRLSPSASPPRRRH 399
Query: 280 DMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRP 339
P PK+ + P PQ R + +++ G+ +
Sbjct: 400 RPSPPATPPPKTRHS---------PTPQQSNRTR----KSRVSVSPGRTSGKVTKHKGTE 446
Query: 340 LRQLVERAPRPTIIN---AENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEV 396
R+ AP+P + +E KG AD+ + S S E+E
Sbjct: 447 KRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER 506
Query: 397 VKDGRPKWNSWDPRRQRQLSMSSADSADAKRTRE---EGKDWAEAVGASRVVRKAPDPQP 453
K K N RR+R SA + KR +E G+ R++P P P
Sbjct: 507 PKRSHVK-NGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAP 565
Query: 454 PPRKLHGWAPGPDYQKSSMGSMFRQQS-------IEDKEDKPPPRQKFIQSEMSEAVERA 506
PPR+ P P + S R S I+ + PP ++ S RA
Sbjct: 566 PPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA 625
Query: 507 R-----KRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVP---WSPS 558
KRR ++ + L K ++ + ++A P SPS
Sbjct: 626 SPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPS 685
Query: 559 AEKASPQENG--PAVHKG---SPEFPAQETPTTFP-------------EEAPTVSPAVAQ 600
+PQ + P V +G SP+ +P+T P ++A + SP +
Sbjct: 686 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVR 745
Query: 601 SNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRT 659
SS +GSP K + P Q Q ++ + P PS P+ +
Sbjct: 746 RVSSSRSV--SGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNS 802
Score = 42.0 bits (97), Expect = 0.007
Identities = 114/600 (19%), Positives = 207/600 (34%), Gaps = 55/600 (9%)
Query: 468 QKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAA 527
++ + SM +Q +DK DK + E S + R + R RR+ R
Sbjct: 137 EQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVR-----R 191
Query: 528 KLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTF 587
+ K+ + + R + A ++ +P + S + P+V + + + P
Sbjct: 192 ERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPK-- 249
Query: 588 PEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQ-----KSLPPRFQR-QQQQQQQEQLY 641
PE P + NS +E+ +E P + + +S P R +++ + + + Y
Sbjct: 250 PEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSY 309
Query: 642 KMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPV-DFYPSALH 700
+ PS +RT PR M P PR +R+PV S+
Sbjct: 310 SPRRRPSPRRRPSPRRRT-----------PPRRMPPP----PRHRRSRSPVRRRRRSSAS 354
Query: 701 PSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLP 760
SG S + + PP + R+++P SP P P P
Sbjct: 355 LSGSSSSSSSSRS-RSPPKKPPKRTSSPPRKTRRLSPSASP----PRRRHRPSPPATPPP 409
Query: 761 HPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKK-----AQAD 815
+ S T R R +S S S GR G + E+R + +K ++ D
Sbjct: 410 KTRHSPTPQQSNRTR-KSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEED 468
Query: 816 FDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDE---KKPECGSWD 872
+++ Q+ ++N Q + G + + P E ++ S
Sbjct: 469 KGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRS 528
Query: 873 VSHQP---ETADTAHGVERETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEPRSSSSQH 929
S P + + G R +P + ++ SP P TP PR +
Sbjct: 529 ASPSPRKRQKETSPRGRRRRSPSPPP----TRRRRSPSPAPPPRRRRTPTPPPRRRTPSP 584
Query: 930 P---EQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSPTAEKD 986
P R S PI++ + + + + S + SP ++
Sbjct: 585 PPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQR 644
Query: 987 EDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEKPDKAWEARPPRESSDVPPMKR 1046
+ S+ + P +T REA + ++ + R P+ SS PP++R
Sbjct: 645 SSPVTKRRSPSLSSKHRKGSSPSRST--REARSPQPNKRHSPSPRPRAPQTSSSPPPVRR 702
Score = 38.1 bits (87), Expect = 0.097
Identities = 50/275 (18%), Positives = 94/275 (34%), Gaps = 35/275 (12%)
Query: 411 RQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPR-------------- 456
+++ SM D KR +EE + E SR R+ P PR
Sbjct: 138 QEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSH 197
Query: 457 ------KLHGWAPGPDYQKSSMGSMFRQQSIEDKED------------KPPPRQKFIQSE 498
+ +P P +K + S++ KE K P + + +
Sbjct: 198 SRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPK 257
Query: 499 MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPS 558
+ ++K +E+E+ R R + ++ + + R+ +R ++
Sbjct: 258 EPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSP 317
Query: 559 AEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEF 618
+ SP+ P + P P + + P S A +SS + + SP ++
Sbjct: 318 RRRPSPRRRTPP-RRMPP--PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKP 374
Query: 619 KYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPP 653
+ S PPR R+ + + P PPP
Sbjct: 375 PKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPP 409
Score = 37.4 bits (85), Expect = 0.17
Identities = 63/257 (24%), Positives = 90/257 (35%), Gaps = 37/257 (14%)
Query: 1248 RRPTDRDYVPDSYRHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQ 1307
RRP+ R P P R R + S + S ++ +R ++ P R
Sbjct: 319 RRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRT 378
Query: 1308 DKPPR-FRRL--------RQERESLGLWGPEEEPHLLAGQW------------PGRPKLC 1346
PPR RRL R+ R S P + H Q PGR
Sbjct: 379 SSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGK 438
Query: 1347 SGDKSGTVGRRSPE-----LSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQV 1401
GT R SP + S ++ + A+ S R+ RR+ S D
Sbjct: 439 VTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSD--- 495
Query: 1402 DGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQN 1461
SG+S + E KRS V R R+ P R +TSPR +++
Sbjct: 496 ----SGSSSSSEDERPKRSHVKNGEVGRR--RRHSPSRSASPSPRKRQKETSPRGRRRRS 549
Query: 1462 GT--PLKVKRSPDEALP 1476
+ P + +RSP A P
Sbjct: 550 PSPPPTRRRRSPSPAPP 566
>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
Length = 1648
Score = 53.5 bits (127), Expect = 2e-06
Identities = 58/228 (25%), Positives = 89/228 (39%), Gaps = 12/228 (5%)
Query: 391 EEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAP- 449
E + + P PRRQR + S S+D +RE K +A SR R+ P
Sbjct: 1023 ESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKR-KKAKDKSREHRRGPW 1081
Query: 450 -DPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARK 508
+ R G Y+ R++ +P R+ S + +
Sbjct: 1082 GHSRRTSRSRSGSPGSSSYEHYES----RKKKKRRSASRPRGRECSPTSSLERLCRHKHQ 1137
Query: 509 RREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENG 568
R ER R+E +A + K+ + +A E R+ +E W P SP+ G
Sbjct: 1138 RERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSRE-KW-PQTRSHSPERKG 1195
Query: 569 PAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQ 616
AV + SP AQ P E+ PT PA+ +++ S E A +P Q
Sbjct: 1196 -AVREASPAPLAQGEPGR--EDLPTRLPALGEAHVSPEVATADKAPLQ 1240
Score = 37.4 bits (85), Expect = 0.17
Identities = 71/258 (27%), Positives = 98/258 (37%), Gaps = 56/258 (21%)
Query: 1102 SSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRG-SENGNEGS 1160
S +++ R R RE R R++ R R S + S EE P+R+R + S +
Sbjct: 1000 SRKKAKRKRVSREHGRTRSGTRSESRDR--SSRSASPSVGEERPRRQRSKAKSRRSSSDR 1057
Query: 1161 LLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFV 1220
RE + KK K S +H RGP G+ RRT
Sbjct: 1058 SSSRERAKRKKA---------KDKSREHR------RGP-------------WGHSRRTSR 1089
Query: 1221 SKESPHWQSKSPGSSWQEYGPSDTCGSRR----PTDRDYVPDSY-----RHPDAFGGRGF 1271
S+ S SPGSS E+ S RR P R+ P S RH R
Sbjct: 1090 SR------SGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQ---RER 1140
Query: 1272 EDSRAEDKRSFF----QDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQERESLGLWG 1327
R + K S + + + S ++E+R RRP ++K P+ R ER+
Sbjct: 1141 SHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSREKWPQTRSHSPERKGA---V 1197
Query: 1328 PEEEPHLLAGQWPGRPKL 1345
E P LA PGR L
Sbjct: 1198 REASPAPLAQGEPGREDL 1215
Score = 33.1 bits (74), Expect = 3.1
Identities = 29/115 (25%), Positives = 52/115 (45%), Gaps = 11/115 (9%)
Query: 1646 RKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPG 1705
R T+ S + + + G + +ESR+ S+ S+ S G +P
Sbjct: 991 RSRSTSSSRSRKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPS--VGEERPRRQRS-- 1046
Query: 1706 LAEPKADSHKEQAPKPS--EQKDSEQGSGQSKEHRPGPIG-NERSLKNRKGSEGA 1757
KA S + + + S E+ ++ +S+EHR GP G + R+ ++R GS G+
Sbjct: 1047 ----KAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGS 1097
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 53.5 bits (127), Expect = 2e-06
Identities = 150/624 (24%), Positives = 222/624 (35%), Gaps = 82/624 (13%)
Query: 1648 AVTAFSSTETGSAEQGFKSSQGDSGVDLSAES-RESSATSSQRSSPYGTLKPEEMSGPGL 1706
AVT S T + SS+G S E +AT S + P T P GP +
Sbjct: 1337 AVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMT-PPSPKRGPAI 1395
Query: 1707 AEPKADSHKEQ----APK--PSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERL 1760
PK D +PK P+ E + SK P SLK +
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAP--- 1452
Query: 1761 QGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSA---SGPTGSPVVKLQDAL 1817
+G P + + + +V P P E +PK S P A P G+P L +
Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKE-PPAPKQVATSSSPKKAPATPAPMGAPT--LPAVI 1509
Query: 1818 ASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGG 1877
S+ + P RRD P++ PTA L K A A + + P + P
Sbjct: 1510 PSSPKEVPATPSSRRD----------PIA-PTATLLSKKTPATLAPKEALIPPAMTVPSP 1558
Query: 1878 AGSGIQP--------PSSVGASS--GVNYSSFGGVSMPP---MPVASVAPS---ASMPGS 1921
+ P PSS ASS V S++ G P +P A +PS A P +
Sbjct: 1559 KKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA 1618
Query: 1922 HLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQA---QAQLGLRGG 1978
PP G P+ P + P S + + P S+ + A QA GL
Sbjct: 1619 VTPPSPEKGPA-TPAPKGTPTSPPVTPSSLKDSPTS--PASVTCKMGATVPQASKGLPAK 1675
Query: 1979 LPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQ-----PLEM 2033
+ +E+ + P + + P+ P T +A PP P + PL
Sbjct: 1676 KGPTALKEVLVAPAPESTPIITAPTRKGPQT---KKSSATSPPICPDPSAKNGSKGPLST 1732
Query: 2034 VKPQSGSPYQPMSGNQALVYEGQLSQAAGLG-----ASQMLDSQLPQLTMPLPRYGS--- 2085
V P P Q S A + S L AS L + + +P P S
Sbjct: 1733 VAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSA 1792
Query: 2086 -GQQPLILPQSIQ----LPPGQSLSVGAPRRIPPPGSQPPVLNTSRE-----PSQMEMKG 2135
P+ LP + LPP Q +P + S+P E P + G
Sbjct: 1793 APSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGG 1852
Query: 2136 FHFADSKQNVP----SGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVD 2191
F N+P +G PVP+P +P + + G + S + SV Q + Q
Sbjct: 1853 VPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSD-ESVPELEEQDSTQATT 1911
Query: 2192 EKPSL-GAVKLQEAPSAASQMKRT 2214
++ L A ++ E P + ++ R+
Sbjct: 1912 QQAQLAAAAEIDEEPVSKAKQSRS 1935
Score = 50.8 bits (120), Expect = 1e-05
Identities = 123/566 (21%), Positives = 181/566 (31%), Gaps = 78/566 (13%)
Query: 1683 SATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPI 1742
S TSS T P+ + P + S K P+ S +G + + P
Sbjct: 912 SMTSSSPKKARATPAPKGI-------PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT 964
Query: 1743 GNERSLKNRKGSEGAERLQGAVVPPV-------NGVEIHVDSVLPVPPIEFGVSPKDSDF 1795
+ + KG +GA PP G P PP SPK S
Sbjct: 965 PPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024
Query: 1796 S--LPPGSASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLT 1853
+ P G+++ P +P S G + P+ + A SP P
Sbjct: 1025 ATPFPKGASTPPAATP--------PSPKGSPAATPLPKGAPTTPAATLPSPKGGP----- 1071
Query: 1854 LKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGAS---SGVNYSSFGGVSMPPMPVA 1910
A + + +P+ P + P G G PS GA + S GG++ PP A
Sbjct: 1072 -----ATPSLKGAPTPPAATPPSPKG-GPATPSPKGAPMPPAATPPSPKGGLATPPHKGA 1125
Query: 1911 SVAPSASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQ 1970
P+A+ P G + P+ P T + A P T+ A
Sbjct: 1126 PTTPAATPPSP-------KGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTT-PAA 1177
Query: 1971 AQLGLRGGLPVSQSQEIFSS------------LQPFRSQVYMHPSLSPPSTMILSGGTAL 2018
+GGL + ++ P P+ +PPS GG A
Sbjct: 1178 TPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP---KGGLAT 1234
Query: 2019 KPPYSAFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQ-LT 2077
P A P P+ G P G S GL + P +T
Sbjct: 1235 PSPKGA-PTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVT 1293
Query: 2078 MPLPRYGSGQQPLILPQSIQLPPGQS--LSVGAPRRIPPPGSQPPVLNTSREPSQMEMKG 2135
P P+ G P P+ PP + G+P PP G+ P T P KG
Sbjct: 1294 PPSPKGGPATSP---PKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP-----KG 1345
Query: 2136 FHFADSKQNVPSGGPV--PSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEK 2193
+ GGP S + P +A+PS K + +G + K +
Sbjct: 1346 TPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPK---GDP 1402
Query: 2194 PSLGAVKLQEAPSAASQMKRTGAIKP 2219
S + L + A+ + R GA P
Sbjct: 1403 TSPAVIPLSPKKAPATPVTREGAATP 1428
Score = 37.0 bits (84), Expect = 0.22
Identities = 63/229 (27%), Positives = 82/229 (35%), Gaps = 27/229 (11%)
Query: 551 KEVPWSPSAEKASPQENGPAV--HKGSPEFPAQETPTTFPEEAP-TVSPAVAQSNSSEEE 607
K P P+A SP + GPA KG+P PA P+ P+ P T SP A + +
Sbjct: 960 KWAPTPPAATPPSP-KGGPATPSPKGAPTPPAATPPS--PKGGPATPSPKGAPTPPAVTP 1016
Query: 608 AREAGSP-AQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQ 666
GSP A F S PP + + P P + P P P
Sbjct: 1017 PSPKGSPAATPFPKGASTPPA-ATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPS 1075
Query: 667 MLGF-DPRWMMMPSYMDPRITPTRTPVDFYPSALHPS---GLMKPMMPQESLNGTGCRSE 722
+ G P PS TP+ P+A PS GL P P + T +
Sbjct: 1076 LKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATP--PHKGAPTTPAATP 1133
Query: 723 DQN----CVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDT 767
PP + TP +PP SP+G G P PK + T
Sbjct: 1134 PSPKGGLATPPPKGAPTTPAATPP--SPKG-------GLATPPPKGAPT 1173
Score = 33.5 bits (75), Expect = 2.4
Identities = 59/219 (26%), Positives = 74/219 (33%), Gaps = 17/219 (7%)
Query: 551 KEVPWSPSAEKASPQENGPAVH--KGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEA 608
K P P+A SP+ GPA KG+P PA P+ A T P A + +
Sbjct: 983 KGAPTPPAATPPSPK-GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPP 1041
Query: 609 REAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQML 668
GSPA K P + P P + P P P
Sbjct: 1042 SPKGSPAAT-PLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100
Query: 669 GFD-PRWMMMPSYMDPRITPTRTPVDFYPSALHPS---GLMKPMMPQESLNGTGCRSEDQ 724
G P PS TP P+A PS GL P P + T +
Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATP--PPKGAPTTPAATPPS 1158
Query: 725 N----CVPPLQERKVTPIDSPPVWSPEGYMALQS-KGYP 758
PP + TP +PP SP+G +A S KG P
Sbjct: 1159 PKGGLATPPPKGAPTTPAATPP--SPKGGLATPSPKGAP 1195
Score = 32.0 bits (71), Expect = 7.0
Identities = 72/301 (23%), Positives = 110/301 (36%), Gaps = 50/301 (16%)
Query: 1916 ASMPGSHLPPLYLDGHVFASQPRLVP--QTIPQQQ-SYQQAAAAQQIPISLHTSLQAQAQ 1972
AS+ G+ P G P ++P Q P+ S+Q +++ +IP+S +L A+
Sbjct: 537 ASLEGAPFSPAQA-GLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATL-AKKS 594
Query: 1973 LG--LRGGLPVSQSQE---IFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPG 2027
LG L G P S + SS ++ Y P + P L + + P +AFP
Sbjct: 595 LGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGP----LLKSSLITPTVAAFP- 649
Query: 2028 MQPLEMVKPQSGSPYQPM-SGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSG 2086
LE P +P + L L + T+PL S
Sbjct: 650 ---LESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASE 706
Query: 2087 QQPLI-LPQS-------IQLPPGQSLSVGAPRRIPPPGSQP---------------PVLN 2123
P+ PQ+ + L P SV +P +PP G+ P PV +
Sbjct: 707 NCPVAPSPQNTCAPLATLVLAPEIPKSVPSPS-LPPAGTPPGTKKVDGISHTSALAPVAS 765
Query: 2124 TSREPSQMEMKGFHFADSKQNVP--SGGPVP-----SPQTYRPSSASPSGKPSGSAVNMG 2176
+ +E + A SK + + P P SPQT RP + S P N+
Sbjct: 766 SPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLS 825
Query: 2177 S 2177
S
Sbjct: 826 S 826
Score = 32.0 bits (71), Expect = 7.0
Identities = 27/73 (36%), Positives = 40/73 (54%), Gaps = 12/73 (16%)
Query: 551 KEVPWSPSAEKAS-PQENGPAVHKGSPE------FPAQETPTTFPEEAPTVSPAVAQSNS 603
KE P +PS+++AS P P+ +KG+P PA +P+ P+EAPT PAV +
Sbjct: 1568 KEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPS--PKEAPT-PPAVTPPSP 1624
Query: 604 SEEEAREA--GSP 614
+ A A G+P
Sbjct: 1625 EKGPATPAPKGTP 1637
>gi|48255931 hepatoma-derived growth factor-related protein 2 isoform
1 [Homo sapiens]
Length = 671
Score = 52.8 bits (125), Expect = 4e-06
Identities = 134/661 (20%), Positives = 225/661 (34%), Gaps = 97/661 (14%)
Query: 1103 SQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLL 1162
++R G GL E + P S SE E E+ + ++
Sbjct: 72 NKRKGFNEGLWEIQNNPHASYSAP-----PPVSSSDSEAPEANPADGSDADEDDEDRGVM 126
Query: 1163 EREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPR-AFGRALPPRLSNCGYGRRTFVS 1221
T R S+ S D+SGL K+ + + + S+ +
Sbjct: 127 AVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSE 186
Query: 1222 KESPHWQSKSPGSSWQEYGPSDTC----------GSRRPTDRDYVPDSYRHPDAFGGRGF 1271
+E+ S+S +S Q++ P G R+ DS D+ G +
Sbjct: 187 EENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPE 246
Query: 1272 EDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKP-PRFRRLRQERESLGLWGPEE 1330
+ A S +DS+ + +P R R+P + P PR R+ + ER +
Sbjct: 247 PVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSD 306
Query: 1331 EPHL-LAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSERRER 1389
+ +W R + R EL + + E + + ERR
Sbjct: 307 SDEVDRISEWKRRDEA-----------RRRELEARRRREQEEELRRLREQEKEEKERRRE 355
Query: 1390 REGPGSEPDSQVDGGLSGASLGEKKELAKR-------------SFSSQRPVVDRQSRKL- 1435
R G + GG SG L E E K+ S S ++R+++K
Sbjct: 356 RADRGEA--ERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSA 413
Query: 1436 -EPGGFGEKPVR-PGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYAL 1493
+P +P R PG + R E +Q P+KV+R+
Sbjct: 414 KKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT----------------------R 451
Query: 1494 ERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGE--E 1551
+R+ S D +K EK+ + + ++ + +F L S ++ C ++ E
Sbjct: 452 KRSEGFSMD------RKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGT 505
Query: 1552 SEVGSMV---GEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNN 1608
+V S + + L K +R ++ +K V +K R L +I +
Sbjct: 506 LQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAG 565
Query: 1609 LCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQ 1668
+ E+ + + G L E +AP + K T S+ G A S +
Sbjct: 566 MEKEKAEEKLAGEELAGE-----------EAPQEKAEDKPSTDLSAPVNGEA----TSQK 610
Query: 1669 GDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKAD-SHKEQAPKPSEQKDS 1727
G+S D E S R L GP L P +D +E+A SE D
Sbjct: 611 GESAEDKEHEEGRDS-EEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDE 669
Query: 1728 E 1728
E
Sbjct: 670 E 670
Score = 40.0 bits (92), Expect = 0.026
Identities = 76/339 (22%), Positives = 122/339 (35%), Gaps = 51/339 (15%)
Query: 322 NDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKGLDDLD-ADADDGWAGLHEEVD 380
+D D + GL R L+ V + R K DLD A E
Sbjct: 144 SDSDKSSDNSGLKRKTPALKMSVSKRAR---------KASSDLDQASVSPSEEENSESSS 194
Query: 381 YSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADS-ADAKRTREEGKDWAEAV 439
SEK D E++ + ++++ S S +DS AD+ + E A +
Sbjct: 195 ESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSA 254
Query: 440 GASRVVRKAPDP----QPPPR----------KLHGWAPGPDYQKSSMGSMFRQQSIEDKE 485
+S + D + PPR K G P P+ SS S S D+
Sbjct: 255 SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS----DSDSDEV 310
Query: 486 DKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEA 545
D+ SE E R+ E RR +EE L +L++ +++ K+ R+
Sbjct: 311 DRI--------SEWKRRDEARRRELEARRRREQEEEL----RRLREQEKEEKERRRERAD 358
Query: 546 RKQAEKEVPWSPSAEKASPQE-----NGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ 600
R +AE+ S E E +G P E EA A
Sbjct: 359 RGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK--KSAKKP 416
Query: 601 SNSSEEEAREAGSPAQEFK---YQKSLPPRFQRQQQQQQ 636
+SS E AR+ G + + Q++ P + +R +++ +
Sbjct: 417 QSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE 455
Score = 32.0 bits (71), Expect = 7.0
Identities = 54/253 (21%), Positives = 103/253 (40%), Gaps = 45/253 (17%)
Query: 388 SDDEEEEEVVKDGR-----PKWNSWDPRR---QRQLSMSSADSADAKRTR-EEGKDWAEA 438
SD E E E+ ++ + P+ +S +P R Q++ + + AK + E + +E
Sbjct: 397 SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 439 VGASRVVRKAPDPQPPPR--KLHGW------APGPDYQKSSMGSMFRQQSIEDKEDKPPP 490
R V K +P + KLH PD ++ ++E+
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCL-------NALEELGTLQVT 509
Query: 491 RQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLD-----QKCKQARKAGEA 545
Q I + ++ V +K R + + E+ A +LK + ++ KAG
Sbjct: 510 SQ--ILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 546 RKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ-SNSS 604
+++AE+++ A + +PQE A++ P+T AP A +Q S+
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEK------------AEDKPST-DLSAPVNGEATSQKGESA 614
Query: 605 EEEAREAGSPAQE 617
E++ E G ++E
Sbjct: 615 EDKEHEEGRDSEE 627
>gi|14249158 hepatoma-derived growth factor-related protein 2 isoform
2 [Homo sapiens]
Length = 670
Score = 51.6 bits (122), Expect = 9e-06
Identities = 134/661 (20%), Positives = 226/661 (34%), Gaps = 98/661 (14%)
Query: 1103 SQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLL 1162
++R G GL E + P S SE E E+ + ++
Sbjct: 72 NKRKGFNEGLWEIQNNPHASYSAP-----PPVSSSDSEAPEANPADGSDADEDDEDRGVM 126
Query: 1163 EREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPR-AFGRALPPRLSNCGYGRRTFVS 1221
T R S+ S D+SGL K+ + + + S+ +
Sbjct: 127 AVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSE 186
Query: 1222 KESPHWQSKSPGSSWQEYGPSDTC----------GSRRPTDRDYVPDSYRHPDAFGGRGF 1271
+E+ S+S +S Q++ P G R+ DS D+ G +
Sbjct: 187 EENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPE 246
Query: 1272 EDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKP-PRFRRLRQERESLGLWGPEE 1330
+ A S +DS+ + +P R R+P + P PR R+ + ER +
Sbjct: 247 PVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSD 306
Query: 1331 EPHL-LAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSERRER 1389
+ +W R + R EL + + E + + ERR
Sbjct: 307 SDEVDRISEWKRRDEA-----------RRRELEARRRREQEEELRRLREQEKEEKERRRE 355
Query: 1390 REGPGSEPDSQVDGGLSGASLGEKKELAKR-------------SFSSQRPVVDRQSRKL- 1435
R G + GG SG L E E K+ S S ++R+++K
Sbjct: 356 RADRGEA--ERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSA 413
Query: 1436 -EPGGFGEKPVR-PGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYAL 1493
+P +P R PG + R E +Q P+KV+R+
Sbjct: 414 KKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT----------------------R 451
Query: 1494 ERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGE--E 1551
+R+ S D +K EK+ + + ++ + +F L S ++ C ++ E
Sbjct: 452 KRSEGFSMD------RKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGT 505
Query: 1552 SEVGSMV---GEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNN 1608
+V S + + L K +R ++ +K V +K R L +I +
Sbjct: 506 LQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAG 565
Query: 1609 LCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQ 1668
+ E+ + + G L E +AP + K T S+ G A S +
Sbjct: 566 MEKEKAEEKLAGEELAGE-----------EAPQEKAEDKPSTDLSAPVNGEA----TSQK 610
Query: 1669 GDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKAD-SHKEQAPKPSEQKDS 1727
G+S D E S + S E GP L P +D +E+A SE D
Sbjct: 611 GESAEDKEHEEGRDSEEGPRCGSSEDLHDVRE--GPDLDRPGSDRQERERARGDSEALDE 668
Query: 1728 E 1728
E
Sbjct: 669 E 669
Score = 40.0 bits (92), Expect = 0.026
Identities = 76/339 (22%), Positives = 122/339 (35%), Gaps = 51/339 (15%)
Query: 322 NDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKGLDDLD-ADADDGWAGLHEEVD 380
+D D + GL R L+ V + R K DLD A E
Sbjct: 144 SDSDKSSDNSGLKRKTPALKMSVSKRAR---------KASSDLDQASVSPSEEENSESSS 194
Query: 381 YSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADS-ADAKRTREEGKDWAEAV 439
SEK D E++ + ++++ S S +DS AD+ + E A +
Sbjct: 195 ESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSA 254
Query: 440 GASRVVRKAPDP----QPPPR----------KLHGWAPGPDYQKSSMGSMFRQQSIEDKE 485
+S + D + PPR K G P P+ SS S S D+
Sbjct: 255 SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS----DSDSDEV 310
Query: 486 DKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEA 545
D+ SE E R+ E RR +EE L +L++ +++ K+ R+
Sbjct: 311 DRI--------SEWKRRDEARRRELEARRRREQEEEL----RRLREQEKEEKERRRERAD 358
Query: 546 RKQAEKEVPWSPSAEKASPQE-----NGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ 600
R +AE+ S E E +G P E EA A
Sbjct: 359 RGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK--KSAKKP 416
Query: 601 SNSSEEEAREAGSPAQEFK---YQKSLPPRFQRQQQQQQ 636
+SS E AR+ G + + Q++ P + +R +++ +
Sbjct: 417 QSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE 455
Score = 32.0 bits (71), Expect = 7.0
Identities = 54/253 (21%), Positives = 103/253 (40%), Gaps = 45/253 (17%)
Query: 388 SDDEEEEEVVKDGR-----PKWNSWDPRR---QRQLSMSSADSADAKRTR-EEGKDWAEA 438
SD E E E+ ++ + P+ +S +P R Q++ + + AK + E + +E
Sbjct: 397 SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
Query: 439 VGASRVVRKAPDPQPPPR--KLHGW------APGPDYQKSSMGSMFRQQSIEDKEDKPPP 490
R V K +P + KLH PD ++ ++E+
Sbjct: 457 FSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCL-------NALEELGTLQVT 509
Query: 491 RQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLD-----QKCKQARKAGEA 545
Q I + ++ V +K R + + E+ A +LK + ++ KAG
Sbjct: 510 SQ--ILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 546 RKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQ-SNSS 604
+++AE+++ A + +PQE A++ P+T AP A +Q S+
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEK------------AEDKPST-DLSAPVNGEATSQKGESA 614
Query: 605 EEEAREAGSPAQE 617
E++ E G ++E
Sbjct: 615 EDKEHEEGRDSEE 627
>gi|27262647 ataxin 2 related protein isoform A [Homo sapiens]
Length = 1075
Score = 51.2 bits (121), Expect = 1e-05
Identities = 71/255 (27%), Positives = 98/255 (38%), Gaps = 39/255 (15%)
Query: 554 PWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGS 613
P PSAE+ +PQ VH+ P Q A PA + S + A S
Sbjct: 840 PQYPSAEQPTPQALYATVHQSYPHHATQ-------LHAHQPQPATTPTGSQPQSQHAAPS 892
Query: 614 PAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP-PS--HPQRTF------YPHH 664
P Q +Q P Q QQ + P PP PS PQ +F Y H
Sbjct: 893 PVQ---HQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH 949
Query: 665 PQML--GFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSE 722
Q L GF + +++ IT P +P A HP +M + P +S G +
Sbjct: 950 HQQLPHGFTNMAHVTQAHVQTGITAAPPP---HPGAPHPPQVML-LHPPQSHGGPPQGAV 1005
Query: 723 DQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSA 782
Q+ VP L TP P + P+G Q+ G+P D R+R E S +
Sbjct: 1006 PQSGVPALSAS--TPSPYPYIGHPQGEQPGQAPGFP---------GGADDRIR-EFSLAG 1053
Query: 783 SL--GRAGGVSAQRD 795
+ GRA G+ +D
Sbjct: 1054 GIWHGRAEGLQVGQD 1068
>gi|27262645 ataxin 2 related protein isoform B [Homo sapiens]
Length = 1062
Score = 50.8 bits (120), Expect = 1e-05
Identities = 61/216 (28%), Positives = 83/216 (38%), Gaps = 27/216 (12%)
Query: 554 PWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGS 613
P PSAE+ +PQ VH+ P Q A PA + S + A S
Sbjct: 840 PQYPSAEQPTPQALYATVHQSYPHHATQ-------LHAHQPQPATTPTGSQPQSQHAAPS 892
Query: 614 PAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP-PS--HPQRTF------YPHH 664
P Q +Q P Q QQ + P PP PS PQ +F Y H
Sbjct: 893 PVQ---HQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH 949
Query: 665 PQML--GFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSE 722
Q L GF + +++ IT P +P A HP +M + P +S G +
Sbjct: 950 HQQLPHGFTNMAHVTQAHVQTGITAAPPP---HPGAPHPPQVML-LHPPQSHGGPPQGAV 1005
Query: 723 DQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYP 758
Q+ VP L TP P + P+G Q+ G+P
Sbjct: 1006 PQSGVPALSAS--TPSPYPYIGHPQGEQPGQAPGFP 1039
>gi|27262649 ataxin 2 related protein isoform C [Homo sapiens]
Length = 1097
Score = 50.8 bits (120), Expect = 1e-05
Identities = 61/216 (28%), Positives = 83/216 (38%), Gaps = 27/216 (12%)
Query: 554 PWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGS 613
P PSAE+ +PQ VH+ P Q A PA + S + A S
Sbjct: 840 PQYPSAEQPTPQALYATVHQSYPHHATQ-------LHAHQPQPATTPTGSQPQSQHAAPS 892
Query: 614 PAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPP-PS--HPQRTF------YPHH 664
P Q +Q P Q QQ + P PP PS PQ +F Y H
Sbjct: 893 PVQ---HQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH 949
Query: 665 PQML--GFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSE 722
Q L GF + +++ IT P +P A HP +M + P +S G +
Sbjct: 950 HQQLPHGFTNMAHVTQAHVQTGITAAPPP---HPGAPHPPQVML-LHPPQSHGGPPQGAV 1005
Query: 723 DQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYP 758
Q+ VP L TP P + P+G Q+ G+P
Sbjct: 1006 PQSGVPALSAS--TPSPYPYIGHPQGEQPGQAPGFP 1039
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 50.1 bits (118), Expect = 2e-05
Identities = 58/277 (20%), Positives = 115/277 (41%), Gaps = 39/277 (14%)
Query: 372 WAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREE 431
W + ++ EK+ +E+EE +++ K + + +RQ M + K R+E
Sbjct: 364 WRQEEKIQEWEEKI-----QEQEEKIREQEEKIREQEEKMRRQEEMMW--EKEEKMRRQE 416
Query: 432 GKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPR 491
W + R + + R+L M Q+ I ++E+K
Sbjct: 417 EMMWEKEEKMRRQEEMMWEKEEKIRELEE-------------KMHEQEKIREQEEKRQEE 463
Query: 492 QKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEK 551
+K + E + E A+ R+EE+ R +EE++ K+ + ++K + K E K+ E+
Sbjct: 464 EKIREQEKRQEQE-AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQ 522
Query: 552 EVPWSPSAEKASPQE----NGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEE 607
E W EK QE +H+ + QE EE + + EE+
Sbjct: 523 EEMWR-QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE---------KMHDQEEK 572
Query: 608 AREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQ 644
RE +E +++ R Q ++ ++Q+E++ + +
Sbjct: 573 IRE----QEEKVWRQEEKIREQEEKIREQEEKIREQE 605
Score = 40.0 bits (92), Expect = 0.026
Identities = 53/295 (17%), Positives = 125/295 (42%), Gaps = 21/295 (7%)
Query: 356 ENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQL 415
E ++ +++ + ++ L E++ EK++ +++ +EE + K + + RQ
Sbjct: 424 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ- 482
Query: 416 SMSSADSADAKRTREEGKDWA--EAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMG 473
+ K +E K W E + +R+ Q W ++
Sbjct: 483 -EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEM---WRQEEKIREQE-- 536
Query: 474 SMFRQ-QSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAR-EERLAACAAKLKQ 531
++RQ + I ++E+K +++ + + + ++ K RE+EE+ R EE++ K+++
Sbjct: 537 EIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIRE 596
Query: 532 LDQKCKQARKAGEAR--KQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPE 589
++K ++ + + + K E+E EK QE + + + QE E
Sbjct: 597 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE--KMRRQEEKIREQEKKIREQE 654
Query: 590 EAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQ 644
E + Q + +E QE K Q+ Q ++ ++Q+E++++ +
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE------QEEKMRRQEEKMWEQE 703
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 50.1 bits (118), Expect = 2e-05
Identities = 80/286 (27%), Positives = 101/286 (35%), Gaps = 65/286 (22%)
Query: 1922 HLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPV 1981
HL L+ Q + Q I Q Q QQ QQ +LQAQ + P+
Sbjct: 219 HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQP---PM 275
Query: 1982 SQ-----SQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYS----------AFP 2026
Q SQ + LQ + P P + + PP S A P
Sbjct: 276 QQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALP 335
Query: 2027 GMQ-----PLEMVKPQ---SGSPYQP-MSGNQALVYEGQLSQAAGLGASQMLDSQLPQLT 2077
G PL+ V+ P QP + Q V Q +Q G Q+ S LP L+
Sbjct: 336 GQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGV-QVSQSSLPMLS 394
Query: 2078 MPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFH 2137
P P GQQ + PQS+ PP S G P SQP
Sbjct: 395 SPSP----GQQ-VQTPQSMPPPPQPSPQPGQP------SSQP------------------ 425
Query: 2138 FADSKQNVPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYV 2183
NV S GP PSP ++ P SPS +PS S V + Q V
Sbjct: 426 ----NSNV-SSGPAPSPSSFLP---SPSPQPSQSPVTARTPQNFSV 463
Score = 43.9 bits (102), Expect = 0.002
Identities = 63/293 (21%), Positives = 116/293 (39%), Gaps = 38/293 (12%)
Query: 454 PPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEE 513
PPR GP MGS+ +PPP + V A + + +
Sbjct: 102 PPR-------GPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQ 154
Query: 514 ERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHK 573
L A + +Q Q+ +Q ++A ++Q +++ A++++ Q+ AV +
Sbjct: 155 --------LQQVALQQQQQQQQFQQQQQAA-LQQQQQQQQQQQFQAQQSAMQQQFQAVVQ 205
Query: 574 GSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQ 633
+ Q+ + + ++++ ++ Q+ + Q+ + Q+QQQ
Sbjct: 206 QQQQLQQQQQQQQH---------LIKLHHQNQQQIQQ-----QQQQLQRIAQLQLQQQQQ 251
Query: 634 QQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPV- 692
QQQQ+Q + Q Q P P + P Q L + M + P P + PV
Sbjct: 252 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA 311
Query: 693 DFYPSALHPSGLMKPMMPQ-ESLNGTGCRSEDQNCVPPLQ-ERKVTPIDSPPV 743
PS L P +P++ Q ++L G ++ PPL+ R + PPV
Sbjct: 312 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQ-----PPLKFVRAPMVVQQPPV 359
Score = 40.4 bits (93), Expect = 0.020
Identities = 73/254 (28%), Positives = 96/254 (37%), Gaps = 38/254 (14%)
Query: 1944 IPQQQSYQQAAAAQQIPISLHTSLQAQ-----------AQLGLRGGLPVSQSQEIFSS-- 1990
+ QQQ QQ QQ I LH Q Q AQL L+ Q Q+
Sbjct: 204 VQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQA 263
Query: 1991 --LQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEM-VKPQSGSPYQPMSG 2047
QP Q M PPS + + P QP + V S P S
Sbjct: 264 LQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQ 323
Query: 2048 NQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQ----LPPGQS 2103
Q LV SQA L QML +Q P + P QQP + PQ Q + Q+
Sbjct: 324 TQPLV-----SQAQAL-PGQMLYTQPPLKFVRAPMVV--QQPPVQPQVQQQQTAVQTAQA 375
Query: 2104 LSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPSSAS 2163
+ AP + S P+L++ Q++ + Q++P P PSPQ +PSS
Sbjct: 376 AQMVAPG-VQVSQSSLPMLSSPSPGQQVQ--------TPQSMPPP-PQPSPQPGQPSSQP 425
Query: 2164 PSGKPSGSAVNMGS 2177
S SG A + S
Sbjct: 426 NSNVSSGPAPSPSS 439
Score = 35.8 bits (81), Expect = 0.48
Identities = 46/180 (25%), Positives = 71/180 (39%), Gaps = 13/180 (7%)
Query: 1912 VAPSASMPGSHL---PPL-YLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSL 1967
V+ + ++PG L PPL ++ + QP + PQ QQ + Q A AAQ + + S
Sbjct: 328 VSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQ 387
Query: 1968 QAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSG----GTALKPPYS 2023
+ L P Q Q S P + S P++ + SG ++ P S
Sbjct: 388 SSLPMLS--SPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPS 445
Query: 2024 AFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRY 2083
P P+ PQ+ S P N + +S A G+SQ + Q L +Y
Sbjct: 446 PQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPA---GSSQAEEQQYLDKLKQLSKY 502
Score = 32.3 bits (72), Expect = 5.3
Identities = 35/146 (23%), Positives = 55/146 (37%), Gaps = 3/146 (2%)
Query: 1688 QRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERS 1747
Q+ + T + +M PG+ ++ +P P +Q + Q + P P G S
Sbjct: 365 QQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQP-GQPSS 423
Query: 1748 LKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGV-SPKDSDFSLPPGSASGPT 1806
N S G + +P + + V P F V SP + + P S P
Sbjct: 424 QPNSNVSSGPAPSPSSFLPSPS-PQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPA 482
Query: 1807 GSPVVKLQDALASNAGLTQSIPILRR 1832
GS + Q L L++ I LRR
Sbjct: 483 GSSQAEEQQYLDKLKQLSKYIEPLRR 508
Score = 32.3 bits (72), Expect = 5.3
Identities = 42/161 (26%), Positives = 62/161 (38%), Gaps = 25/161 (15%)
Query: 906 GSPNKQPSSEPEWTPEPRSSS-----SQHPEQTGRTRRS---------GPIKKPVLKALK 951
G P+ QP+S P P SS S P Q+ T R+ GP+ PV +
Sbjct: 419 GQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSV 478
Query: 952 VE---DKEKELEKIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGP 1008
+ + E ++ +L + S + + +K+ED + D S S L D P
Sbjct: 479 MSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTD--P 536
Query: 1009 GHATFGREATKFE---EEEKPDKAWEARPPRESSDVPPMKR 1046
+ K E E+ K D A PP VPP K+
Sbjct: 537 SKRCPLKTLQKCEIALEKLKNDMAVPTPPP---PPVPPTKQ 574
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 50.1 bits (118), Expect = 2e-05
Identities = 147/615 (23%), Positives = 208/615 (33%), Gaps = 113/615 (18%)
Query: 1572 RLLEEERRKKEQAVQVPVKGRGL-SSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWES 1630
+L EEERR Q V + +GL +PP A+ + ++ D + P G
Sbjct: 47 QLSEEERR---QIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRP---- 99
Query: 1631 SSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRS 1690
D R A S + T F+S Q G R S S + S
Sbjct: 100 -----------PDPGRPAQPGLSKSRTTDT---FRSEQKLPG-------RSPSTISLKES 138
Query: 1691 SPYGTLKPEEMSG--PG-LAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERS 1747
LK E S PG L+E A S D S S+E E +
Sbjct: 139 KSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQE--------ETT 190
Query: 1748 LKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVP--------PIEFGVSPKDSDFSLPP 1799
K + + + +G + PP + P+P P++ +PK P
Sbjct: 191 KKQKVVQKEQGKPEGIIKPP-----LQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE 245
Query: 1800 GSASGP--TGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKME 1857
S P TG P+ G TQ+ +QR S AD+ ++ E
Sbjct: 246 KIKSQPPGTGKPI----------QGPTQTPQTDHAKLPLQR--DASRPQTKQADI-VRGE 292
Query: 1858 SARKAWENSPSLP--EQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPS 1915
S + + SPS P +Q +PG +PP+ G S G P P P
Sbjct: 293 SVKPSLP-SPSKPPIQQPTPG------KPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPL 342
Query: 1916 ASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGL 1975
A PG+ PP+ G L P P QQ+ + +++Q +A AQ
Sbjct: 343 AQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQ------PGPKALAQPPG 396
Query: 1976 RGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQ-PLEMV 2034
G P Q P + P T + GT P + PG+Q P +
Sbjct: 397 VGKTPAQQ------------------PGPAKPPTQQV--GT--PKPLAQQPGLQSPAKAP 434
Query: 2035 KPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRY-GSGQQPLILP 2093
P QP G G +A SQLP P P+ G + P P
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP 494
Query: 2094 QSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPS 2153
S + P Q S P + P P P S +P + A PS +
Sbjct: 495 GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGS---AKPSAQQPSPAKPSA 551
Query: 2154 PQTYRPSSASPSGKP 2168
Q+ +P S + SGKP
Sbjct: 552 QQSTKPVSQTGSGKP 566
Score = 40.0 bits (92), Expect = 0.026
Identities = 123/642 (19%), Positives = 216/642 (33%), Gaps = 102/642 (15%)
Query: 56 RMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGL 115
+ P P P+ + ++ + P P +G QQ + QPP + P
Sbjct: 307 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP--GTVKPPVQPPGTTKPPA- 363
Query: 116 QKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTL 175
+ + + P Q E +S GPK+ AQ G G + P + PT
Sbjct: 364 -QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV---------GKTPAQQPGPAKPPT- 412
Query: 176 KAAGGQDKAGKEKGVLDLSYGPGPSLR------PQNVTSWREGGGRHIISATSLSTSPTE 229
+ G ++ G+ + PGP+ P + + + G G+ T + P++
Sbjct: 413 QQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472
Query: 230 LGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSP 289
L G P +K P +P K SQ G+ PP P
Sbjct: 473 L------PGPAKPPPQQPGPAKPPPQQPGS--AKPPSQQPGSTKPPPQQPGPAKPSPQQP 524
Query: 290 KSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPR 349
S++ + P Q + P P Q ++ G +PL+P
Sbjct: 525 GSTKPPSQQPGSAKPSAQ-QPSPAKPSAQ----QSTKPVSQTGSGKPLQP---------- 569
Query: 350 PTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVV-----KDGRP-- 402
PT+ + L + EK F+ E + V + P
Sbjct: 570 PTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629
Query: 403 ----KWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKL 458
+W + + +R L D A + + A S V + +P PQ K
Sbjct: 630 TEVKEWLCLNCQMKRAL---GGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK 686
Query: 459 HGWAPGPDYQKS-----------------SMGSMFRQQSIEDKEDKP-PPRQKFIQSEMS 500
AP D K+ S + +Q D KP PP++ + SE
Sbjct: 687 DA-APKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQD 745
Query: 501 EAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAE 560
+A K ++ + + + +++ +A K ++P S
Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSSSATTK--------------------PDIPSSKVQS 785
Query: 561 KASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKY 620
+A + P K P+Q P T + +P S A+ + S + G P+ E K
Sbjct: 786 QAEEKTTPPL--KTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPG-PSSESKG 842
Query: 621 QKSLPPRFQRQQQQQQQEQLYKMQHWQPV---YPPPSHPQRT 659
QK + P ++++ ++ Q ++ +P+ P P P+ T
Sbjct: 843 QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884
Score = 37.4 bits (85), Expect = 0.17
Identities = 34/167 (20%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 863 EKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEP 922
+++PE ++ PE G ++ + SS+ SP S + + P
Sbjct: 1694 DEEPELEMESLTDSPEDRSRGEG--------SSSLHASSFTPGTSPTSVSSLDEDSDSSP 1745
Query: 923 RSSSSQHPEQT-GRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSP 981
+ +Q R R GP+ + + + E+ +E E +K++ + + K S
Sbjct: 1746 SHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSK 1805
Query: 982 TAEKDEDE------ENDASLANSSTTTLEDKGPGHATFGREATKFEE 1022
++KD+DE S+ + +ED P R+A + EE
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEEL--RQAAEMEE 1850
Score = 36.6 bits (83), Expect = 0.28
Identities = 53/199 (26%), Positives = 75/199 (37%), Gaps = 24/199 (12%)
Query: 2021 PYSAFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLT--- 2077
P PG PL+ Q G+P + +S Q E SQ G G +Q PQ
Sbjct: 220 PKQQGPGRDPLQ----QDGTP-KSISSQQP---EKIKSQPPGTGKPIQGPTQTPQTDHAK 271
Query: 2078 MPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQP-PVLNTSREPSQMEMKGF 2136
+PL R S Q + + G+S+ P PP QP P +++P + +
Sbjct: 272 LPLQRDASRPQT----KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327
Query: 2137 HFADSKQNVPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSL 2196
Q PSG + P +P + P +P G+ G A+Q EKPS
Sbjct: 328 PAKPPAQ--PSG--LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPS- 382
Query: 2197 GAVKLQEAPSAASQMKRTG 2215
Q P A +Q G
Sbjct: 383 ---SEQPGPKALAQPPGVG 398
Score = 34.7 bits (78), Expect = 1.1
Identities = 29/122 (23%), Positives = 49/122 (40%), Gaps = 15/122 (12%)
Query: 906 GSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQE 965
G P S P + + SQ P G + +G K++ V+ + K
Sbjct: 950 GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETK-------- 1001
Query: 966 LGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK 1025
+ +L + EQ+PT ++ E E+ + +S + T E P A TK E+ K
Sbjct: 1002 -APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAE---PQKAVL---PTKLEKSPK 1054
Query: 1026 PD 1027
P+
Sbjct: 1055 PE 1056
Score = 31.6 bits (70), Expect = 9.1
Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 7/124 (5%)
Query: 922 PRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSP 981
P++S P ++ + + P P +K +K +++E + E K L + L+ EK P
Sbjct: 1132 PKASPMPVPTESSSQKTAVP---PQVKLVKKQEQEVKTEAEKVILEKVKETLSMEK--IP 1186
Query: 982 TAEKDEDEENDASLANSSTTTLEDKGP--GHATFGREATKFEEEEKPDKAWEARPPRESS 1039
+ ++ ++ L + L++K P E K EEK E +P E
Sbjct: 1187 PMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDK 1246
Query: 1040 DVPP 1043
+ P
Sbjct: 1247 KLLP 1250
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 50.1 bits (118), Expect = 2e-05
Identities = 147/615 (23%), Positives = 208/615 (33%), Gaps = 113/615 (18%)
Query: 1572 RLLEEERRKKEQAVQVPVKGRGL-SSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWES 1630
+L EEERR Q V + +GL +PP A+ + ++ D + P G
Sbjct: 47 QLSEEERR---QIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRP---- 99
Query: 1631 SSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRS 1690
D R A S + T F+S Q G R S S + S
Sbjct: 100 -----------PDPGRPAQPGLSKSRTTDT---FRSEQKLPG-------RSPSTISLKES 138
Query: 1691 SPYGTLKPEEMSG--PG-LAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERS 1747
LK E S PG L+E A S D S S+E E +
Sbjct: 139 KSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQE--------ETT 190
Query: 1748 LKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVP--------PIEFGVSPKDSDFSLPP 1799
K + + + +G + PP + P+P P++ +PK P
Sbjct: 191 KKQKVVQKEQGKPEGIIKPP-----LQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE 245
Query: 1800 GSASGP--TGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKME 1857
S P TG P+ G TQ+ +QR S AD+ ++ E
Sbjct: 246 KIKSQPPGTGKPI----------QGPTQTPQTDHAKLPLQR--DASRPQTKQADI-VRGE 292
Query: 1858 SARKAWENSPSLP--EQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPS 1915
S + + SPS P +Q +PG +PP+ G S G P P P
Sbjct: 293 SVKPSLP-SPSKPPIQQPTPG------KPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPL 342
Query: 1916 ASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGL 1975
A PG+ PP+ G L P P QQ+ + +++Q +A AQ
Sbjct: 343 AQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQ------PGPKALAQPPG 396
Query: 1976 RGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQ-PLEMV 2034
G P Q P + P T + GT P + PG+Q P +
Sbjct: 397 VGKTPAQQ------------------PGPAKPPTQQV--GT--PKPLAQQPGLQSPAKAP 434
Query: 2035 KPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRY-GSGQQPLILP 2093
P QP G G +A SQLP P P+ G + P P
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP 494
Query: 2094 QSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPS 2153
S + P Q S P + P P P S +P + A PS +
Sbjct: 495 GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGS---AKPSAQQPSPAKPSA 551
Query: 2154 PQTYRPSSASPSGKP 2168
Q+ +P S + SGKP
Sbjct: 552 QQSTKPVSQTGSGKP 566
Score = 40.0 bits (92), Expect = 0.026
Identities = 123/642 (19%), Positives = 216/642 (33%), Gaps = 102/642 (15%)
Query: 56 RMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGL 115
+ P P P+ + ++ + P P +G QQ + QPP + P
Sbjct: 307 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP--GTVKPPVQPPGTTKPPA- 363
Query: 116 QKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTL 175
+ + + P Q E +S GPK+ AQ G G + P + PT
Sbjct: 364 -QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV---------GKTPAQQPGPAKPPT- 412
Query: 176 KAAGGQDKAGKEKGVLDLSYGPGPSLR------PQNVTSWREGGGRHIISATSLSTSPTE 229
+ G ++ G+ + PGP+ P + + + G G+ T + P++
Sbjct: 413 QQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472
Query: 230 LGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSP 289
L G P +K P +P K SQ G+ PP P
Sbjct: 473 L------PGPAKPPPQQPGPAKPPPQQPGS--AKPPSQQPGSTKPPPQQPGPAKPSPQQP 524
Query: 290 KSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPR 349
S++ + P Q + P P Q ++ G +PL+P
Sbjct: 525 GSTKPPSQQPGSAKPSAQ-QPSPAKPSAQ----QSTKPVSQTGSGKPLQP---------- 569
Query: 350 PTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVV-----KDGRP-- 402
PT+ + L + EK F+ E + V + P
Sbjct: 570 PTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629
Query: 403 ----KWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKL 458
+W + + +R L D A + + A S V + +P PQ K
Sbjct: 630 TEVKEWLCLNCQMKRAL---GGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK 686
Query: 459 HGWAPGPDYQKS-----------------SMGSMFRQQSIEDKEDKP-PPRQKFIQSEMS 500
AP D K+ S + +Q D KP PP++ + SE
Sbjct: 687 DA-APKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQD 745
Query: 501 EAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAE 560
+A K ++ + + + +++ +A K ++P S
Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSSSATTK--------------------PDIPSSKVQS 785
Query: 561 KASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKY 620
+A + P K P+Q P T + +P S A+ + S + G P+ E K
Sbjct: 786 QAEEKTTPPL--KTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPG-PSSESKG 842
Query: 621 QKSLPPRFQRQQQQQQQEQLYKMQHWQPV---YPPPSHPQRT 659
QK + P ++++ ++ Q ++ +P+ P P P+ T
Sbjct: 843 QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884
Score = 37.4 bits (85), Expect = 0.17
Identities = 34/167 (20%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 863 EKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEP 922
+++PE ++ PE G ++ + SS+ SP S + + P
Sbjct: 1694 DEEPELEMESLTDSPEDRSRGEG--------SSSLHASSFTPGTSPTSVSSLDEDSDSSP 1745
Query: 923 RSSSSQHPEQT-GRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSP 981
+ +Q R R GP+ + + + E+ +E E +K++ + + K S
Sbjct: 1746 SHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSK 1805
Query: 982 TAEKDEDE------ENDASLANSSTTTLEDKGPGHATFGREATKFEE 1022
++KD+DE S+ + +ED P R+A + EE
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEEL--RQAAEMEE 1850
Score = 36.6 bits (83), Expect = 0.28
Identities = 53/199 (26%), Positives = 75/199 (37%), Gaps = 24/199 (12%)
Query: 2021 PYSAFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLT--- 2077
P PG PL+ Q G+P + +S Q E SQ G G +Q PQ
Sbjct: 220 PKQQGPGRDPLQ----QDGTP-KSISSQQP---EKIKSQPPGTGKPIQGPTQTPQTDHAK 271
Query: 2078 MPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQP-PVLNTSREPSQMEMKGF 2136
+PL R S Q + + G+S+ P PP QP P +++P + +
Sbjct: 272 LPLQRDASRPQT----KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327
Query: 2137 HFADSKQNVPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSL 2196
Q PSG + P +P + P +P G+ G A+Q EKPS
Sbjct: 328 PAKPPAQ--PSG--LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPS- 382
Query: 2197 GAVKLQEAPSAASQMKRTG 2215
Q P A +Q G
Sbjct: 383 ---SEQPGPKALAQPPGVG 398
Score = 34.7 bits (78), Expect = 1.1
Identities = 29/122 (23%), Positives = 49/122 (40%), Gaps = 15/122 (12%)
Query: 906 GSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQE 965
G P S P + + SQ P G + +G K++ V+ + K
Sbjct: 950 GQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETK-------- 1001
Query: 966 LGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEK 1025
+ +L + EQ+PT ++ E E+ + +S + T E P A TK E+ K
Sbjct: 1002 -APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAE---PQKAVL---PTKLEKSPK 1054
Query: 1026 PD 1027
P+
Sbjct: 1055 PE 1056
Score = 31.6 bits (70), Expect = 9.1
Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 7/124 (5%)
Query: 922 PRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSP 981
P++S P ++ + + P P +K +K +++E + E K L + L+ EK P
Sbjct: 1132 PKASPMPVPTESSSQKTAVP---PQVKLVKKQEQEVKTEAEKVILEKVKETLSMEK--IP 1186
Query: 982 TAEKDEDEENDASLANSSTTTLEDKGP--GHATFGREATKFEEEEKPDKAWEARPPRESS 1039
+ ++ ++ L + L++K P E K EEK E +P E
Sbjct: 1187 PMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDK 1246
Query: 1040 DVPP 1043
+ P
Sbjct: 1247 KLLP 1250
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 50.1 bits (118), Expect = 2e-05
Identities = 83/344 (24%), Positives = 128/344 (37%), Gaps = 71/344 (20%)
Query: 1837 QRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNY 1896
Q+ +G SP + L+++ A P PE P + P A+S +
Sbjct: 555 QQDVG-SPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASD 613
Query: 1897 SSFGG-----------VSMPPMPVASVAPSASMPGSHL--PPLYLDGHVFASQPRLVPQT 1943
S+F S + + S+A +A P + PP+ S+ ++PQ+
Sbjct: 614 STFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPV--------SEGPVLPQS 665
Query: 1944 IPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPS 2003
+P +YQQ AA +P+ S+ A A P S Q F P
Sbjct: 666 LPSLGAYQQPTAAPGLPVG---SVPAPA-------CPPSLQQHFPDPAMSFA------PV 709
Query: 2004 LSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGL 2063
L PPST + +G P A PG QP + +P +P + Q +V
Sbjct: 710 LPPPSTPMPTG-----PGQPAPPGQQPPPLAQP---TPLPQVLAPQPVV----------- 750
Query: 2064 GASQMLDSQLPQLTMPLPRYGSGQQ--PLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPV 2121
Q + LP P + G+ Q PL +PQ+ P Q P ++PP PP+
Sbjct: 751 -PLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQ-----VPPQMPPIPVVPPI 804
Query: 2122 LNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPSSASPS 2165
+ + G A + PVP PQ + P+ PS
Sbjct: 805 TPLA------GIDGLPPALPDLPTATVPPVPPPQYFSPAVILPS 842
Score = 37.4 bits (85), Expect = 0.17
Identities = 70/299 (23%), Positives = 106/299 (35%), Gaps = 75/299 (25%)
Query: 1912 VAPSASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQA 1971
+ P A P P S P L ++P + S A Q+ S A
Sbjct: 1315 ICPVAEHPAPEAPE---------SSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLA-- 1363
Query: 1972 QLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFP--GMQ 2029
SQ++ S P +P +PP+ + S PP +A P G
Sbjct: 1364 ------------SQQLLSQAGP------SNPPGAPPAPLAPSS-----PPVTALPQDGAA 1400
Query: 2030 PLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQ-- 2087
P P+ S G SQA G G Q L S+L + + PL
Sbjct: 1401 PATSTMPEPAS--------------GTASQAGGPGTPQGLTSEL-ETSQPLAETHEAPLA 1445
Query: 2088 -QPLILPQSIQLPPGQSLSV---GAPRR-IPPPGSQPPVLNTSREPSQME--------MK 2134
QPL++ + P ++ S APR +PPP +P + + +P+ + +
Sbjct: 1446 VQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVG 1505
Query: 2135 GFHFADSKQNVPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEK 2193
A S+ P GP PQ PS+ G+ G +G +V + +DEK
Sbjct: 1506 AVSLATSQLPSPPLGPTVPPQP--PSALESDGE--GPPPRVG-----FVDSTIKSLDEK 1555
Score = 32.7 bits (73), Expect = 4.1
Identities = 49/208 (23%), Positives = 72/208 (34%), Gaps = 25/208 (12%)
Query: 564 PQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKS 623
P GP + + P A + PT P PA A S ++ P +
Sbjct: 655 PVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQH-----FPDPAMSFAPV 709
Query: 624 LPPRF--------QRQQQQQQQEQLYKMQHW-QPVYPPPSHPQRTFYPHHPQMLGFDPRW 674
LPP Q QQ L + Q + P P P + PH P L
Sbjct: 710 LPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLA-PASQ 768
Query: 675 MMMPSYMDPRITPTR--TPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQE 732
+ P+ + P P P+ P + P ++ P+ P ++G +P L
Sbjct: 769 VGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGL------PPALPDLPT 822
Query: 733 RKVTPIDSPPVWSPEGYMALQSKGYPLP 760
V P+ P +SP + L S PLP
Sbjct: 823 ATVPPVPPPQYFSPA--VILPSLAAPLP 848
Score = 32.0 bits (71), Expect = 7.0
Identities = 42/154 (27%), Positives = 54/154 (35%), Gaps = 23/154 (14%)
Query: 562 ASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQ 621
++P GP G P P Q+ P P PT P V A + P Q
Sbjct: 714 STPMPTGP----GQPAPPGQQPP---PLAQPTPLPQVL--------APQPVVPLQPVP-- 756
Query: 622 KSLPPRFQRQQQQQQQEQLYKMQHWQ-PVYP----PPSHPQRTFYPHHPQMLGFDPRWMM 676
LPP Q QL +Q Q P+ P PP P P + G D
Sbjct: 757 PHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPA 816
Query: 677 MPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMP 710
+P + P P F P+ + PS L P+ P
Sbjct: 817 LPDLPTATVPPVPPPQYFSPAVILPS-LAAPLPP 849
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,807,957
Number of Sequences: 37866
Number of extensions: 6486895
Number of successful extensions: 42661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 1200
Number of HSP's that attempted gapping in prelim test: 29755
Number of HSP's gapped (non-prelim): 11467
length of query: 2229
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2111
effective length of database: 13,779,330
effective search space: 29088165630
effective search space used: 29088165630
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.