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Search of human proteins with 14916494
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14916494 retinoic acid receptor, beta isoform 1 [Homo
sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 912 0.0
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 687 0.0
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 679 0.0
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 677 0.0
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 677 0.0
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 676 0.0
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 659 0.0
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 479 e-135
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 250 2e-66
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 237 1e-62
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 237 1e-62
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 237 1e-62
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 225 7e-59
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 222 5e-58
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 205 8e-53
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 205 8e-53
gi|11415052 retinoid X receptor, beta [Homo sapiens] 202 5e-52
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 201 9e-52
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 199 6e-51
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 192 4e-49
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 192 4e-49
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 191 1e-48
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 188 7e-48
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 188 7e-48
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 188 7e-48
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 177 2e-44
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 177 2e-44
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 177 2e-44
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 177 2e-44
gi|238550159 estrogen-related receptor beta [Homo sapiens] 172 4e-43
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 912 bits (2356), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS 60
MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS
Sbjct: 1 MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS 60
Query: 61 SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD
Sbjct: 61 SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
Query: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL 180
KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL
Sbjct: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL 180
Query: 181 TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP
Sbjct: 181 TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
Query: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
Sbjct: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
Query: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR
Sbjct: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
Query: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSS 420
PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSS
Sbjct: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSS 420
Query: 421 SGNTAEHSPSISPSSVENSGVSQSPLVQ 448
SGNTAEHSPSISPSSVENSGVSQSPLVQ
Sbjct: 421 SGNTAEHSPSISPSSVENSGVSQSPLVQ 448
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 687 bits (1772), Expect = 0.0
Identities = 346/460 (75%), Positives = 385/460 (83%), Gaps = 18/460 (3%)
Query: 1 MFDCMDVLSVSPGQIL--DFYTASPSSCMLQEKALKA---CFSGLTQTEWQHRHTAQSIE 55
M++ ++V +P L DFY + +C+L EK L A + L W + SIE
Sbjct: 1 MYESVEVGGPTPNPFLVVDFYNQN-RACLLPEKGLPAPGPYSTPLRTPLWNGSN--HSIE 57
Query: 56 TQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY 115
TQS+SSEE+VPSPPSP P PR+YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM+Y
Sbjct: 58 TQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY 117
Query: 116 TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTA 175
TCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY +T
Sbjct: 118 TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTP 177
Query: 176 ELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEF 235
E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK VEF
Sbjct: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
Query: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295
AK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF
Sbjct: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
Query: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355
GPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEALK+Y
Sbjct: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
Query: 356 IRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEP 415
+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG +
Sbjct: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDT 417
Query: 416 LTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 445
L+ G + SPS+SPSS +S + SP
Sbjct: 418 LSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 457
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 679 bits (1753), Expect = 0.0
Identities = 326/414 (78%), Positives = 364/414 (87%), Gaps = 2/414 (0%)
Query: 1 MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS 60
M+DCM+ + P ++ + A P + +L+ +CF+GL W + QS+ETQSTS
Sbjct: 1 MYDCMETFAPGPRRL--YGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTS 58
Query: 61 SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
SEE+VPS PSP PPPRVYKPCFVC DKSSGYHYGVS+CEGCKGFFRRSIQKNM+YTCHRD
Sbjct: 59 SEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 118
Query: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL 180
KNC+INKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKE ++ +SYE++ +L++L
Sbjct: 119 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEEL 178
Query: 181 TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
K+ KAHQETFPSLCQLGKYTTNSSADHRV+LDLGLWDKFSELATKCIIKIVEFAKRLP
Sbjct: 179 ITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLP 238
Query: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
GFTGL+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
Sbjct: 239 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 298
Query: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
LVF FA QLLPLEMDDTETGLLSAICLICGDR DLEEP KVDKLQEPLLEAL++Y R+RR
Sbjct: 299 LVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRR 358
Query: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHE 414
PS+P+MFP++LMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E E
Sbjct: 359 PSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFE 412
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 677 bits (1748), Expect = 0.0
Identities = 330/403 (81%), Positives = 360/403 (89%), Gaps = 10/403 (2%)
Query: 53 SIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 112
+IETQS+SSEE+VPSPPSP P PR+YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN
Sbjct: 60 TIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119
Query: 113 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 172
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY
Sbjct: 120 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 179
Query: 173 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 232
+T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 180 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 239
Query: 233 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 292
VEFAK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 240 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 299
Query: 293 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 352
AGFGPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEAL
Sbjct: 300 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 359
Query: 353 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 412
K+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 360 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 419
Query: 413 HEPLTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 445
+ L+ G + SPS+SPSS +S + SP
Sbjct: 420 LDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 677 bits (1748), Expect = 0.0
Identities = 330/403 (81%), Positives = 360/403 (89%), Gaps = 10/403 (2%)
Query: 53 SIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 112
+IETQS+SSEE+VPSPPSP P PR+YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN
Sbjct: 60 TIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119
Query: 113 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 172
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY
Sbjct: 120 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 179
Query: 173 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 232
+T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 180 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 239
Query: 233 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 292
VEFAK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 240 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 299
Query: 293 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 352
AGFGPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEAL
Sbjct: 300 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 359
Query: 353 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 412
K+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 360 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 419
Query: 413 HEPLTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 445
+ L+ G + SPS+SPSS +S + SP
Sbjct: 420 LDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 676 bits (1745), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 113 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 172
MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE
Sbjct: 1 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 60
Query: 173 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 232
MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI
Sbjct: 61 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 120
Query: 233 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 292
VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 121 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 180
Query: 293 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 352
AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL
Sbjct: 181 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 240
Query: 353 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 412
KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 241 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 300
Query: 413 HEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ 448
HEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
Sbjct: 301 HEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ 336
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 659 bits (1700), Expect = 0.0
Identities = 317/382 (82%), Positives = 345/382 (90%)
Query: 33 LKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYH 92
L F GL Q + + S+ETQSTSSEE+VPS PSP PPPRVYKPCFVC DKSSGYH
Sbjct: 42 LSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYH 101
Query: 93 YGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVR 152
YGVS+CEGCKGFFRRSIQKNM+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKE+VR
Sbjct: 102 YGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVR 161
Query: 153 NDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR 212
NDRNKKKKE ++ +SYE++ +L++L K+ KAHQETFPSLCQLGKYTTNSSADHRV+
Sbjct: 162 NDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQ 221
Query: 213 LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTP 272
LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGL+IADQITLLKAACLDIL+LRICTRYTP
Sbjct: 222 LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTP 281
Query: 273 EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDR 332
EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVF FA QLLPLEMDDTETGLLSAICLICGDR
Sbjct: 282 EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDR 341
Query: 333 QDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLK 392
DLEEP KVDKLQEPLLEAL++Y R+RRPS+P+MFP++LMKITDLR IS KGAER ITLK
Sbjct: 342 MDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLK 401
Query: 393 MEIPGSMPPLIQEMLENSEGHE 414
MEIPG MPPLI+EMLEN E E
Sbjct: 402 MEIPGPMPPLIREMLENPEMFE 423
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 479 bits (1234), Expect = e-135
Identities = 241/309 (77%), Positives = 266/309 (86%), Gaps = 10/309 (3%)
Query: 147 SKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSS 206
S +VRNDRNKKKKE K EC+ESY +T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S
Sbjct: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
Query: 207 ADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRI 266
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT LTIADQITLLKAACLDILILRI
Sbjct: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
Query: 267 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAIC 326
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVF FANQLLPLEMDD ETGLLSAIC
Sbjct: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
Query: 327 LICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAE 386
LICGDRQDLE+P +VD LQEPLLEALK+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAE
Sbjct: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
Query: 387 RVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEH----------SPSISPSSV 436
RVITLKMEIPGSMPPLIQEMLENSEG + L+ G + SPS+SPSS
Sbjct: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
Query: 437 ENSGVSQSP 445
+S + SP
Sbjct: 357 RSSPATHSP 365
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 250 bits (639), Expect = 2e-66
Identities = 139/357 (38%), Positives = 201/357 (56%), Gaps = 26/357 (7%)
Query: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--IYTCHRDKNCVINKVTRNRCQYCRL 138
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D CVI+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 139 QKCFEVGMSKESVRND-------------RNKKKKETSKQECTESYEMTAELDDLTEKIR 185
+KC VGM+ + V +D R +++KE + + E T E DL
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 186 KAHQETFPSLC---QLGKYTTNSSADHRV-------RLDLGLWDKFSELATKCIIKIVEF 235
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355
G ++D +F L +DDTE LL A+ L+ DR L K++K QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 356 IRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSM-PPLIQEMLENSE 411
+ R+ + PH +PK+LMK+TDLR I A A R + +K+E P + PPL E+ E+ E
Sbjct: 353 VNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQE 409
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 237 bits (605), Expect = 1e-62
Identities = 139/386 (36%), Positives = 209/386 (54%), Gaps = 32/386 (8%)
Query: 50 TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109
+AQ+ +T+ + +PS + C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDK------DELCVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 110 QKNM--IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 154
QKN+ Y+C + CVI+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 155 RNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS------ 205
R K+++E ++ E T E +L + + +AH T Q K+
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 206 -SADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 264
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 265 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSA 324
R RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 325 ICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKG 384
+ L+ DR L +++K Q+ L A + YI R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 385 AERVITLKMEIPGSM-PPLIQEMLEN 409
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 237 bits (605), Expect = 1e-62
Identities = 139/386 (36%), Positives = 209/386 (54%), Gaps = 32/386 (8%)
Query: 50 TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109
+AQ+ +T+ + +PS + C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDK------DELCVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 110 QKNM--IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 154
QKN+ Y+C + CVI+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 155 RNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS------ 205
R K+++E ++ E T E +L + + +AH T Q K+
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 206 -SADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 264
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 265 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSA 324
R RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 325 ICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKG 384
+ L+ DR L +++K Q+ L A + YI R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 385 AERVITLKMEIPGSM-PPLIQEMLEN 409
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 237 bits (605), Expect = 1e-62
Identities = 139/386 (36%), Positives = 209/386 (54%), Gaps = 32/386 (8%)
Query: 50 TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109
+AQ+ +T+ + +PS + C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDK------DELCVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 110 QKNM--IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 154
QKN+ Y+C + CVI+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 155 RNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS------ 205
R K+++E ++ E T E +L + + +AH T Q K+
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 206 -SADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 264
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 265 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSA 324
R RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 325 ICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKG 384
+ L+ DR L +++K Q+ L A + YI R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 385 AERVITLKMEIPGSM-PPLIQEMLEN 409
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 225 bits (573), Expect = 7e-59
Identities = 127/331 (38%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--IYTCHRDKNCVINKVTRNRCQYCRL 138
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D CVI+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 139 QKCFEVGMSKESVRND-------------RNKKKKETSKQECTESYEMTAELDDLTEKIR 185
+KC VGM+ + V +D R +++KE + + E T E DL
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 186 KAHQETFPSLC---QLGKYTTNSSADHRV-------RLDLGLWDKFSELATKCIIKIVEF 235
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355
G ++D +F L +DDTE LL A+ L+ DR L K++K QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 356 IRKRRPSKPHMFPKILMKITDLR-SISAKGA 385
+ R+ + PH +PK+LMK +++ SI KGA
Sbjct: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 222 bits (566), Expect = 5e-58
Identities = 129/362 (35%), Positives = 200/362 (55%), Gaps = 23/362 (6%)
Query: 59 TSSEELVPSP----------PSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRS 108
+SSE++ P P PS P V C +C D+SSG HYGV +CEGCKGFF+R+
Sbjct: 107 SSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRT 166
Query: 109 IQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK-KKKETSKQEC 167
I+K++IYTC +K+C+I+K RNRCQYCR QKC +GM +E+V+ +R + +++ S+ EC
Sbjct: 167 IRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAEC 226
Query: 168 TESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATK 227
S D E+I +A P G +S + V A K
Sbjct: 227 ATS----GHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPV-------TNICHAADK 275
Query: 228 CIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 287
+ +VE+AKR+P F+ LT+ DQ+ LL+A ++LI R QD + + GL ++R
Sbjct: 276 QLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHR 335
Query: 288 TQMHNAGFGPLTDLVFT-FANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQE 346
+ H+AG G + D V T +++ ++MD +E G L AI L D + L P++V+ L+E
Sbjct: 336 SSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLRE 395
Query: 347 PLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEM 406
+ L+ Y +++ P +P F K+L+++ LRSI K E + K+ + + EM
Sbjct: 396 KVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 455
Query: 407 LE 408
LE
Sbjct: 456 LE 457
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 205 bits (521), Expect = 8e-53
Identities = 127/414 (30%), Positives = 219/414 (52%), Gaps = 28/414 (6%)
Query: 24 SSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQS---TSSEELVPSPPSPLPPPRVY-- 78
SSC+L+E+A +G T ++ T++ + E+ P P P++
Sbjct: 36 SSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGN 95
Query: 79 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRL 138
+ C VC DK+SG+HY V +CEGCKGFFRRS+ K Y CH +C ++ R +CQ CRL
Sbjct: 96 ELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRL 155
Query: 139 QKCFEVGMSKESVRNDRNKKKKETSKQECTESY----------------EMTAELDDLTE 182
+KC + GM +E V ++ + K+ +QE +++ +++ E + E
Sbjct: 156 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIE 215
Query: 183 KIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKR 238
K+ A Q+ +F ++ + + H + F+ELA + +IV+FAK+
Sbjct: 216 KLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQ 274
Query: 239 LPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 297
LPGF L+ DQI LLK + +++++L RY P +++TF + NR AG
Sbjct: 275 LPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVE 334
Query: 298 LTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIR 357
+ +F F+ + L+++D E LL AI + DR ++++ +V++LQ +EAL Y+
Sbjct: 335 FINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS 394
Query: 358 KRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411
P MFP++LMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 395 IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 447
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 205 bits (521), Expect = 8e-53
Identities = 122/349 (34%), Positives = 191/349 (54%), Gaps = 16/349 (4%)
Query: 65 VPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCV 124
VP+ PS C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+
Sbjct: 119 VPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL 178
Query: 125 INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK-KKKETSKQECTESYEMTAELDDLTEK 183
I+K RNRCQYCR QKC +GM +E+V+ +R + K + ++ E T S A D E+
Sbjct: 179 IDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSS----ANEDMPVER 234
Query: 184 IRKAHQETFP---SLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
I +A P + + SS + V + A K + +VE+AKR+P
Sbjct: 235 ILEAELAVEPKTETYVEANMGLNPSSPNDPV-------TNICQAADKQLFTLVEWAKRIP 287
Query: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
F+ L + DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D
Sbjct: 288 HFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD 347
Query: 301 LVFT-FANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKR 359
V T +++ ++MD TE G L AI L D + L P +V+ L+E + +L+ Y + +
Sbjct: 348 RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHK 407
Query: 360 RPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
P +P F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 408 YPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 202 bits (514), Expect = 5e-52
Identities = 114/342 (33%), Positives = 186/342 (54%), Gaps = 7/342 (2%)
Query: 68 PPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINK 127
PP P P + C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y+C +K+C ++K
Sbjct: 192 PPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDK 251
Query: 128 VTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKA 187
RNRCQYCR QKC GM +E+V+ +R + K + E +D + E
Sbjct: 252 RQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAV 311
Query: 188 HQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTI 247
Q++ + G + S+ + ++ + A K + +VE+AKR+P F+ L +
Sbjct: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQAADKQLFTLVEWAKRIPHFSSLPL 365
Query: 248 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFT-FA 306
DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D V T
Sbjct: 366 DDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELV 425
Query: 307 NQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHM 366
+++ + MD TE G L AI L D + L P++V+ L+E + +L+ Y +++ P +
Sbjct: 426 SKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGR 485
Query: 367 FPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 486 FAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 201 bits (512), Expect = 9e-52
Identities = 118/372 (31%), Positives = 201/372 (54%), Gaps = 25/372 (6%)
Query: 63 ELVPSPPSPLPPPRVY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
E+ P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y CH
Sbjct: 33 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 92
Query: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESY--------- 171
+C ++ R +CQ CRL+KC + GM +E V ++ + K+ +QE +++
Sbjct: 93 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 152
Query: 172 -------EMTAELDDLTEKIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLDLGLWDK 220
+++ E + EK+ A Q+ +F ++ + + H +
Sbjct: 153 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 211
Query: 221 FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 280
F+ELA + +IV+FAK+LPGF L+ DQI LLK + +++++L RY P +++TF
Sbjct: 212 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 271
Query: 281 DGLTLNRTQMHNAGFG-PLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPT 339
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 272 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 331
Query: 340 KVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSM 399
+V++LQ +EAL Y+ P MFP++LMK+ LR++S+ +E+V L+++ +
Sbjct: 332 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 390
Query: 400 PPLIQEMLENSE 411
PPL+ E+ + E
Sbjct: 391 PPLLSEIWDVHE 402
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 199 bits (505), Expect = 6e-51
Identities = 119/363 (32%), Positives = 201/363 (55%), Gaps = 15/363 (4%)
Query: 49 HTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRS 108
H +Q ++TQ VPSPPS P C VC D ++ HYGV CEGCKGFF+R+
Sbjct: 239 HASQLLDTQ-------VPSPPSRGSPSNEGL-CAVCGDNAACQHYGVRTCEGCKGFFKRT 290
Query: 109 IQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND--RNKKKKETSKQE 166
+QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D + ++ + SK +
Sbjct: 291 VQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK 350
Query: 167 CTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR-LDLGLWDKFSELA 225
+ + L + +AH ++ P++ L ++ D+++ D +F +L
Sbjct: 351 SPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLL 410
Query: 226 TKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTL 285
T + I +A+++PGF L ADQ L ++A L++ +LR+ R P + + F +G+ L
Sbjct: 411 TGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVL 470
Query: 286 NRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQ 345
+R Q GFG D + F++ L + +D + ++A+ ++ +R L+EP +V++LQ
Sbjct: 471 HRLQCVR-GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQ 528
Query: 346 EPLLEALKIYIRKRRP--SKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLI 403
++ LK ++ ++P+ K+L K+ +LR++ +G +R+ LK+E P +I
Sbjct: 529 NKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAII 588
Query: 404 QEM 406
++
Sbjct: 589 DKL 591
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 192 bits (489), Expect = 4e-49
Identities = 126/378 (33%), Positives = 195/378 (51%), Gaps = 14/378 (3%)
Query: 32 ALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGY 91
++ F GL T H + ++T TS++ +P C VC D +S
Sbjct: 225 SMPTAFPGLAPTS-PHLEGSGILDTPVTSTKARSGAPGGS------EGRCAVCGDNASCQ 277
Query: 92 HYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESV 151
HYGV CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QKC VGM KE V
Sbjct: 278 HYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVV 337
Query: 152 RNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSA-DHR 210
R D K ++ + A +L + +AH ++ PS +L H
Sbjct: 338 RTDSLKGRR--GRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHF 395
Query: 211 VRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRY 270
+ D G +F +L + + I ++A+++PGF L+ ADQ LL++A L++ ILR+ R
Sbjct: 396 GKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRS 455
Query: 271 TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICG 330
P + + F GL L+R Q GFG D + F+ L L +D LSA+ LI
Sbjct: 456 KPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT- 513
Query: 331 DRQDLEEPTKVDKLQEPLLEALKIYIR--KRRPSKPHMFPKILMKITDLRSISAKGAERV 388
DR L+EP +V++LQ + LK ++ P ++L K+ +LR++ +G +R+
Sbjct: 514 DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRI 573
Query: 389 ITLKMEIPGSMPPLIQEM 406
LK+E PP+I ++
Sbjct: 574 FYLKLEDLVPPPPIIDKI 591
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 192 bits (489), Expect = 4e-49
Identities = 126/378 (33%), Positives = 195/378 (51%), Gaps = 14/378 (3%)
Query: 32 ALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGY 91
++ F GL T H + ++T TS++ +P C VC D +S
Sbjct: 225 SMPTAFPGLAPTS-PHLEGSGILDTPVTSTKARSGAPGGS------EGRCAVCGDNASCQ 277
Query: 92 HYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESV 151
HYGV CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QKC VGM KE V
Sbjct: 278 HYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVV 337
Query: 152 RNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSA-DHR 210
R D K ++ + A +L + +AH ++ PS +L H
Sbjct: 338 RTDSLKGRR--GRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHF 395
Query: 211 VRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRY 270
+ D G +F +L + + I ++A+++PGF L+ ADQ LL++A L++ ILR+ R
Sbjct: 396 GKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRS 455
Query: 271 TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICG 330
P + + F GL L+R Q GFG D + F+ L L +D LSA+ LI
Sbjct: 456 KPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT- 513
Query: 331 DRQDLEEPTKVDKLQEPLLEALKIYIR--KRRPSKPHMFPKILMKITDLRSISAKGAERV 388
DR L+EP +V++LQ + LK ++ P ++L K+ +LR++ +G +R+
Sbjct: 514 DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRI 573
Query: 389 ITLKMEIPGSMPPLIQEM 406
LK+E PP+I ++
Sbjct: 574 FYLKLEDLVPPPPIIDKI 591
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 191 bits (485), Expect = 1e-48
Identities = 123/411 (29%), Positives = 208/411 (50%), Gaps = 57/411 (13%)
Query: 56 TQSTSSEELVPSPPS---------PLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFR 106
+ + S++ ++P P P P ++ C VC DK+SG+HY V +CEGCKGFFR
Sbjct: 53 SSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFR 112
Query: 107 RSIQKNMI--YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGM------SKESVRNDRNKK 158
RS+ + Y C C ++ R +CQ CRL+KC E GM S+E +R + +K
Sbjct: 113 RSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRK 172
Query: 159 KKETSKQECTES---------------------------------YEMTAELDDLTEKIR 185
+++ Q ++S ++TA + + +++
Sbjct: 173 QQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLV 232
Query: 186 KA----HQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPG 241
A ++ +F ++ + + R + F+ELA + +IV+FAK++PG
Sbjct: 233 AAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR-FAHFTELAIISVQEIVDFAKQVPG 291
Query: 242 FTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTD 300
F L DQI LLKA+ ++I++L RY E + +TF T ++ H AG +
Sbjct: 292 FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFIN 351
Query: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
+F F+ + L +DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +R
Sbjct: 352 PIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKR 411
Query: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411
P FP++LMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 412 PQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 188 bits (478), Expect = 7e-48
Identities = 124/365 (33%), Positives = 183/365 (50%), Gaps = 28/365 (7%)
Query: 59 TSSEELVPSPPSPLPPPRVYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMI 114
T+S L SP P PP R C VC D ++ HYGV CEGCKGFF+R++QKN
Sbjct: 277 TASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAK 336
Query: 115 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKETSKQE 166
Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K +QE
Sbjct: 337 YVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQE 396
Query: 167 CTESYEMTAELDDLTEKIRKAHQET-----FPSLCQLGKYTTNSSADHRVRLDLGLWDKF 221
++ + + + +R T + C + + A+H +F
Sbjct: 397 PSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEH--------VQQF 448
Query: 222 SELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 281
L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 449 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 508
Query: 282 GLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKV 341
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+EP +V
Sbjct: 509 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 566
Query: 342 DKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPP 401
++L + +LK + K + +P K+L + +LR I G +R+ LK+E S P
Sbjct: 567 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 625
Query: 402 LIQEM 406
+I ++
Sbjct: 626 IIDKL 630
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 188 bits (478), Expect = 7e-48
Identities = 124/365 (33%), Positives = 183/365 (50%), Gaps = 28/365 (7%)
Query: 59 TSSEELVPSPPSPLPPPRVYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMI 114
T+S L SP P PP R C VC D ++ HYGV CEGCKGFF+R++QKN
Sbjct: 266 TASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAK 325
Query: 115 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKETSKQE 166
Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K +QE
Sbjct: 326 YVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQE 385
Query: 167 CTESYEMTAELDDLTEKIRKAHQET-----FPSLCQLGKYTTNSSADHRVRLDLGLWDKF 221
++ + + + +R T + C + + A+H +F
Sbjct: 386 PSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEH--------VQQF 437
Query: 222 SELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 281
L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 282 GLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKV 341
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+EP +V
Sbjct: 498 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 555
Query: 342 DKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPP 401
++L + +LK + K + +P K+L + +LR I G +R+ LK+E S P
Sbjct: 556 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 614
Query: 402 LIQEM 406
+I ++
Sbjct: 615 IIDKL 619
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 188 bits (478), Expect = 7e-48
Identities = 124/365 (33%), Positives = 183/365 (50%), Gaps = 28/365 (7%)
Query: 59 TSSEELVPSPPSPLPPPRVYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMI 114
T+S L SP P PP R C VC D ++ HYGV CEGCKGFF+R++QKN
Sbjct: 266 TASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAK 325
Query: 115 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKETSKQE 166
Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K +QE
Sbjct: 326 YVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQE 385
Query: 167 CTESYEMTAELDDLTEKIRKAHQET-----FPSLCQLGKYTTNSSADHRVRLDLGLWDKF 221
++ + + + +R T + C + + A+H +F
Sbjct: 386 PSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEH--------VQQF 437
Query: 222 SELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 281
L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 282 GLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKV 341
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+EP +V
Sbjct: 498 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 555
Query: 342 DKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPP 401
++L + +LK + K + +P K+L + +LR I G +R+ LK+E S P
Sbjct: 556 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 614
Query: 402 LIQEM 406
+I ++
Sbjct: 615 IIDKL 619
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 177 bits (448), Expect = 2e-44
Identities = 115/357 (32%), Positives = 178/357 (49%), Gaps = 12/357 (3%)
Query: 54 IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 113
+E T E ++ S P L C VC D +SGYHYGV++CE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPKRL--------CLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 114 IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM 173
Y+C C I K R CQ CR KC +VGM KE VR DR + ++ K+ E
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRI--DAEN 195
Query: 174 TAELD-DLTEKIRKAHQETFPSLCQLGKYTTNSSADHRV-RLDLGLWDKFSELATKCIIK 231
+ L+ L + +K + + L + D V D+ +LA + ++
Sbjct: 196 SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVV 255
Query: 232 IVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH 291
I+ +AK +PGF+ L++ADQ++LL++A ++ILIL + R +D + ++D ++ Q
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSK 315
Query: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351
AG L + + + ++++ E L AI L D +E+ V KLQ+ L EA
Sbjct: 316 LAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEA 375
Query: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
L+ Y + P K+LM + LR S K + +K+E M L EMLE
Sbjct: 376 LQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 177 bits (448), Expect = 2e-44
Identities = 115/357 (32%), Positives = 178/357 (49%), Gaps = 12/357 (3%)
Query: 54 IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 113
+E T E ++ S P L C VC D +SGYHYGV++CE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPKRL--------CLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 114 IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM 173
Y+C C I K R CQ CR KC +VGM KE VR DR + ++ K+ E
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRI--DAEN 195
Query: 174 TAELD-DLTEKIRKAHQETFPSLCQLGKYTTNSSADHRV-RLDLGLWDKFSELATKCIIK 231
+ L+ L + +K + + L + D V D+ +LA + ++
Sbjct: 196 SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVV 255
Query: 232 IVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH 291
I+ +AK +PGF+ L++ADQ++LL++A ++ILIL + R +D + ++D ++ Q
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSK 315
Query: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351
AG L + + + ++++ E L AI L D +E+ V KLQ+ L EA
Sbjct: 316 LAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEA 375
Query: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
L+ Y + P K+LM + LR S K + +K+E M L EMLE
Sbjct: 376 LQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 177 bits (448), Expect = 2e-44
Identities = 115/357 (32%), Positives = 178/357 (49%), Gaps = 12/357 (3%)
Query: 54 IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 113
+E T E ++ S P L C VC D +SGYHYGV++CE CK FF+R+IQ N+
Sbjct: 109 VEDPQTKCEYMLNSMPKRL--------CLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 160
Query: 114 IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM 173
Y+C C I K R CQ CR KC +VGM KE VR DR + ++ K+ E
Sbjct: 161 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRI--DAEN 218
Query: 174 TAELD-DLTEKIRKAHQETFPSLCQLGKYTTNSSADHRV-RLDLGLWDKFSELATKCIIK 231
+ L+ L + +K + + L + D V D+ +LA + ++
Sbjct: 219 SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVV 278
Query: 232 IVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH 291
I+ +AK +PGF+ L++ADQ++LL++A ++ILIL + R +D + ++D ++ Q
Sbjct: 279 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSK 338
Query: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351
AG L + + + ++++ E L AI L D +E+ V KLQ+ L EA
Sbjct: 339 LAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEA 398
Query: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
L+ Y + P K+LM + LR S K + +K+E M L EMLE
Sbjct: 399 LQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 177 bits (448), Expect = 2e-44
Identities = 115/357 (32%), Positives = 178/357 (49%), Gaps = 12/357 (3%)
Query: 54 IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 113
+E T E ++ S P L C VC D +SGYHYGV++CE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPKRL--------CLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 114 IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM 173
Y+C C I K R CQ CR KC +VGM KE VR DR + ++ K+ E
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRI--DAEN 195
Query: 174 TAELD-DLTEKIRKAHQETFPSLCQLGKYTTNSSADHRV-RLDLGLWDKFSELATKCIIK 231
+ L+ L + +K + + L + D V D+ +LA + ++
Sbjct: 196 SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVV 255
Query: 232 IVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMH 291
I+ +AK +PGF+ L++ADQ++LL++A ++ILIL + R +D + ++D ++ Q
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSK 315
Query: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351
AG L + + + ++++ E L AI L D +E+ V KLQ+ L EA
Sbjct: 316 LAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEA 375
Query: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
L+ Y + P K+LM + LR S K + +K+E M L EMLE
Sbjct: 376 LQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 172 bits (437), Expect = 4e-43
Identities = 109/349 (31%), Positives = 175/349 (50%), Gaps = 20/349 (5%)
Query: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQK 140
C VC D +SGYHYGV++CE CK FF+R+IQ N+ Y+C C I K R CQ CR K
Sbjct: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
Query: 141 CFEVGMSKESVRNDRNK--KKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQL 198
C +VGM KE VR DR + ++K + + S ++ ++ +K L ++
Sbjct: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKK----------PLTKI 212
Query: 199 GKYTTNSSADHRVRL--------DLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQ 250
Y + D + D+ +LA + ++ I+ +AK +PGF+ L++ DQ
Sbjct: 213 VSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQ 272
Query: 251 ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLL 310
++LL++A ++ILIL I R P D + +++ ++ AG L + +
Sbjct: 273 MSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYK 332
Query: 311 PLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKI 370
L+++ E L A+ L D +E+ V KLQ+ L EAL+ Y +R +P K+
Sbjct: 333 KLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKL 392
Query: 371 LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPS 419
L+ + LR +AK + ++K++ M L EMLE G E L S
Sbjct: 393 LLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGS 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,430,073
Number of Sequences: 37866
Number of extensions: 864959
Number of successful extensions: 6306
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 5800
Number of HSP's gapped (non-prelim): 361
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.