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Search of human proteins with 148806900
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148806900 epidermis-specific serine protease-like protein
[Homo sapiens]
(328 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148806900 epidermis-specific serine protease-like protein [Ho... 685 0.0
gi|13994276 marapsin [Homo sapiens] 203 2e-52
gi|5803197 testisin isoform 1 [Homo sapiens] 202 3e-52
gi|21614531 testisin isoform 2 [Homo sapiens] 202 3e-52
gi|4506153 prostasin preproprotein [Homo sapiens] 199 3e-51
gi|117956391 protease, serine, 33 [Homo sapiens] 194 7e-50
gi|205360905 testis-specific serine protease 1 [Homo sapiens] 193 2e-49
gi|11545839 protease, serine, 22 [Homo sapiens] 189 3e-48
gi|34098976 marapsin 2 [Homo sapiens] 189 4e-48
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 186 2e-47
gi|21614533 testisin isoform 3 [Homo sapiens] 180 1e-45
gi|58218970 protease, serine, 36 [Homo sapiens] 180 2e-45
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 178 7e-45
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 178 7e-45
gi|68508970 tryptase beta 2 precursor [Homo sapiens] 176 2e-44
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 176 3e-44
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 174 1e-43
gi|4503627 coagulation factor XI precursor [Homo sapiens] 173 2e-43
gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 173 2e-43
gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 173 2e-43
gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 173 2e-43
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 173 2e-43
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 172 3e-43
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 168 7e-42
gi|33186882 testis serine protease 2 [Homo sapiens] 166 2e-41
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 166 3e-41
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 165 6e-41
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 165 6e-41
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 160 1e-39
gi|110815798 ovochymase 1 [Homo sapiens] 160 1e-39
>gi|148806900 epidermis-specific serine protease-like protein [Homo
sapiens]
Length = 328
Score = 685 bits (1768), Expect = 0.0
Identities = 328/328 (100%), Positives = 328/328 (100%)
Query: 1 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSE 60
MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSE
Sbjct: 1 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSE 60
Query: 61 RLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKL 120
RLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKL
Sbjct: 61 RLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKL 120
Query: 121 SSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQA 180
SSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQA
Sbjct: 121 SSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQA 180
Query: 181 CEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSW 240
CEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSW
Sbjct: 181 CEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSW 240
Query: 241 GLECGKSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRPSCAFGPNTI 300
GLECGKSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRPSCAFGPNTI
Sbjct: 241 GLECGKSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRPSCAFGPNTI 300
Query: 301 HRVGTVAEAVACIQGWEENAWRFSPRGR 328
HRVGTVAEAVACIQGWEENAWRFSPRGR
Sbjct: 301 HRVGTVAEAVACIQGWEENAWRFSPRGR 328
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 203 bits (516), Expect = 2e-52
Identities = 115/277 (41%), Positives = 153/277 (55%), Gaps = 13/277 (4%)
Query: 3 PAGCAFTLLLLLG------ISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGS 56
PA LLL G + CG+P +R+VGGQD G WPWQVS+ + + CGGS
Sbjct: 4 PAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGS 63
Query: 57 LVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKY-YVSKIVIHPKYQDT--TA 113
L++E+ +LTAAHC + T T Y V LG+ + Y V ++ +P YQ T +A
Sbjct: 64 LIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSA 123
Query: 114 DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEV 173
DVAL++L + V FT+ ILP+CLP + CWVTGWG E LQ+ V
Sbjct: 124 DVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAV 183
Query: 174 PIIDRQACEQLYNPIGIFLPALEP-VIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVW 232
PIID C LY+ F +P IK D +CAG + KD+CKGDSGGPL C + W
Sbjct: 184 PIIDTPKCNLLYSKDTEF--GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSW 241
Query: 233 IQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISR 268
+Q GV+SWG C + + PGVY V + WI+ I +
Sbjct: 242 LQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPK 278
>gi|5803197 testisin isoform 1 [Homo sapiens]
Length = 314
Score = 202 bits (515), Expect = 3e-52
Identities = 114/284 (40%), Positives = 164/284 (57%), Gaps = 18/284 (6%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG+ V +SR+VGG+DA GRWPWQ SL + +CG SL+S R LTAAHC + T++ S
Sbjct: 33 CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFE-TYSDLS 91
Query: 79 ----YTVWLGSITVGDS-----RKRVKYYVSKIVIHPKYQDTTA-DVALLKLSSQVTFTS 128
+ V G +T S +Y+VS I + P+Y + D+AL+KLS+ VT+T
Sbjct: 92 DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 151
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
I PICL + T + CWVTGWG +KE LQE +V II+ C L+
Sbjct: 152 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 211
Query: 189 GIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-S 247
+ I D +CAG+ Q KD+C GDSGGPL+C+ +G+W Q GVVSWG+ CG+ +
Sbjct: 212 -----SFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPN 266
Query: 248 LPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRP 291
PGVYTN+ ++ +WI +++ + + D +P++ L P
Sbjct: 267 RPGVYTNISHHFEWIQKLMAQ-SGMSQPDPSWPLLFFPLLWALP 309
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 202 bits (515), Expect = 3e-52
Identities = 113/281 (40%), Positives = 162/281 (57%), Gaps = 14/281 (4%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG+ V +SR+VGG+DA GRWPWQ SL + +CG SL+S R LTAAHC + + S
Sbjct: 33 CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92
Query: 79 -YTVWLGSITVGDS-----RKRVKYYVSKIVIHPKYQDTTA-DVALLKLSSQVTFTSAIL 131
+ V G +T S +Y+VS I + P+Y + D+AL+KLS+ VT+T I
Sbjct: 93 GWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQ 152
Query: 132 PICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIF 191
PICL + T + CWVTGWG +KE LQE +V II+ C L+
Sbjct: 153 PICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY--- 209
Query: 192 LPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-SLPG 250
+ I D +CAG+ Q KD+C GDSGGPL+C+ +G+W Q GVVSWG+ CG+ + PG
Sbjct: 210 --SFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 267
Query: 251 VYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRP 291
VYTN+ ++ +WI +++ + + D +P++ L P
Sbjct: 268 VYTNISHHFEWIQKLMAQ-SGMSQPDPSWPLLFFPLLWALP 307
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 199 bits (506), Expect = 3e-51
Identities = 106/247 (42%), Positives = 146/247 (59%), Gaps = 8/247 (3%)
Query: 26 SRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGS 85
+R+ GG A AG+WPWQVS+ ++ +CGGSLVSE+ +L+AAHC +Y V LG+
Sbjct: 43 ARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA 102
Query: 86 ITVGDSRKRVKYYVSKIVI-HPKY--QDTTADVALLKLSSQVTFTSAILPICLPSVTKQL 142
+ + K K +I HP Y + + D+ALL+LS +TF+ I PICLP+
Sbjct: 103 HQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASF 162
Query: 143 AIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEP-VIKE 201
C VTGWG V S LQ+ EVP+I R+ C LYN I EP ++E
Sbjct: 163 PNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYN---IDAKPEEPHFVQE 219
Query: 202 DKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQK 260
D +CAG + KD+C+GDSGGPLSC ++G+W TG+VSWG CG ++ PGVYT Y
Sbjct: 220 DMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYAS 279
Query: 261 WINATIS 267
WI + ++
Sbjct: 280 WIQSKVT 286
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 194 bits (494), Expect = 7e-50
Identities = 105/270 (38%), Positives = 151/270 (55%), Gaps = 13/270 (4%)
Query: 10 LLLLLGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSER 61
LLL+LG + CGQP SSR+VGG+D G WPWQ S+ +CGGSL++ +
Sbjct: 11 LLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQ 70
Query: 62 LILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQDTTA--DVALL 118
+LTAAHC Y V LG++ +G + R + V ++++ P Y + A D+ALL
Sbjct: 71 WVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALL 130
Query: 119 KLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDR 178
+L V ++ + P+CLP + C VTGWG ++ LQ VP++D
Sbjct: 131 QLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDS 190
Query: 179 QACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVV 238
+ C+ LY+ +G +P E ++ +CAG Q KD+C+GDSGGPL+C G W+ GVV
Sbjct: 191 RTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVV 249
Query: 239 SWGLECG-KSLPGVYTNVIYYQKWINATIS 267
SWG C + PGVYT+V Y WI A +S
Sbjct: 250 SWGKGCALPNRPGVYTSVATYSPWIQARVS 279
>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
Length = 318
Score = 193 bits (490), Expect = 2e-49
Identities = 104/261 (39%), Positives = 146/261 (55%), Gaps = 17/261 (6%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG + V GG ++A GRWPWQ SL CGGSL+S R +L+AAHC Q +
Sbjct: 46 CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSE 105
Query: 79 YTVWLGSITVGDSRKRVKYYVSK-----IVIHPKYQDTTA-DVALLKLSSQVTFTSAILP 132
+TV LG +T + ++ Y S+ I+++P D+ALL+L+S VT+ + I P
Sbjct: 106 WTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQP 165
Query: 133 ICLPSVTKQLAIPPFCWVTGWGKVKESS---DRDYHSALQEAEVPIIDRQACEQLYNPIG 189
IC+ S T P CWVTGWG + S Y+ L+EA+V I++ C L+
Sbjct: 166 ICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYN--LREAQVTILNNTRCNYLFEQ-- 221
Query: 190 IFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-SL 248
P+ +I + CAG D+CKGDSGGPL C DG+W Q G+VSWG++CG+ +
Sbjct: 222 ---PSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278
Query: 249 PGVYTNVIYYQKWINATISRA 269
PGVYTN+ Y WI +S +
Sbjct: 279 PGVYTNISVYFHWIRRVMSHS 299
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 189 bits (480), Expect = 3e-48
Identities = 100/282 (35%), Positives = 155/282 (54%), Gaps = 25/282 (8%)
Query: 5 GC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHN 50
GC FT LLLL + CG+P +RVVGG+D+ WPW VS+ +
Sbjct: 13 GCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGT 72
Query: 51 FICGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-KYYVSKIVIHPKY 108
C GSL++ R ++TAAHC + + ++V LG+ +G+ R K V+ + HP Y
Sbjct: 73 HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVY 132
Query: 109 ---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYH 165
+ AD+AL++L + F+ +LPICLP + L CW++GWG +++ +
Sbjct: 133 SWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHP 192
Query: 166 SALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLS 225
LQ+ +VPIID + C LY + A + I ED +CAG + +D+C GDSGGPL
Sbjct: 193 QTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLM 247
Query: 226 CHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATI 266
C +DG W+ G++SWG C ++ PGVY ++ ++ W+ +
Sbjct: 248 CQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289
>gi|34098976 marapsin 2 [Homo sapiens]
Length = 326
Score = 189 bits (479), Expect = 4e-48
Identities = 93/255 (36%), Positives = 144/255 (56%), Gaps = 16/255 (6%)
Query: 13 LLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQP 72
L G CG+P +++GG A +WPWQVS+H+ +CGGS+++E +L+AAHC
Sbjct: 45 LTGSVACGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHR 104
Query: 73 TWTTFSYTVWLGSITVGDSRKRVKYY-VSKIVIHPKYQ---DTTADVALLKLSSQVTFTS 128
Y +++G + + + ++Y V+++++HP Y+ DVAL++L +++ F+
Sbjct: 105 DKNIKIYDMYVGLVNLRVAGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSE 164
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
++LP+CL + L CW TGWG V + + LQE ++P+I C LY +
Sbjct: 165 SVLPVCLATPEVNLT-SANCWATGWGLVSKQGETS--DELQEMQLPLILEPWCHLLYGHM 221
Query: 189 GIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGKSL 248
+P D +CAGD N K C+GDSGGPL C + W+Q G+VSWG C L
Sbjct: 222 SYIMP--------DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPL 273
Query: 249 -PGVYTNVIYYQKWI 262
PGVY +V Y+ KWI
Sbjct: 274 YPGVYASVSYFSKWI 288
>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
Length = 321
Score = 186 bits (473), Expect = 2e-47
Identities = 117/322 (36%), Positives = 166/322 (51%), Gaps = 41/322 (12%)
Query: 1 MGPAGCAFTLLLLL-GISV------CGQPVYSS---RVVGGQDAAAGRWPWQVSLHFDHN 50
M C LLL + G+S+ CG+P S R+VGG A AG WPWQ SL
Sbjct: 1 MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV 60
Query: 51 FICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIH--PKY 108
+CGGSL+S + +LTAAHC + + Y V LG + + S V +I++H P
Sbjct: 61 HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--VRQIILHSSPSG 118
Query: 109 Q-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSA 167
Q T+ D+AL++LS VT +S ILP+CLP + CWVTGWG +E +
Sbjct: 119 QPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYS 178
Query: 168 LQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCH 227
L+E +V ++D + C + Y G +++ D +CA + D+C+ DSGGPL C
Sbjct: 179 LREVKVSVVDTETCRRDYPGPG------GSILQPDMLCA---RGPGDACQDDSGGPLVCQ 229
Query: 228 IDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLD--------FSDFL 278
++G W+Q G+VSWG CG+ + PGVYT V Y WI I+ + + + F
Sbjct: 230 VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFF 289
Query: 279 FP--------IVLLSLALLRPS 292
P VLL+ LL PS
Sbjct: 290 LPGLFLLLVSCVLLAKCLLHPS 311
>gi|21614533 testisin isoform 3 [Homo sapiens]
Length = 300
Score = 180 bits (457), Expect = 1e-45
Identities = 109/284 (38%), Positives = 159/284 (55%), Gaps = 32/284 (11%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG+ V +SR+VGG+DA GRWPWQ SL + +CG SL+S R LTAAHC + T++ S
Sbjct: 33 CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFE-TYSDLS 91
Query: 79 ----YTVWLGSITVGDS-----RKRVKYYVSKIVIHPKY-QDTTADVALLKLSSQVTFTS 128
+ V G +T S +Y+VS I + P+Y ++ D+AL+KLS+ VT+T
Sbjct: 92 DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 151
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
I PICL + T + CWVTGWG +KE LQE +V II+ C L+
Sbjct: 152 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLF--- 208
Query: 189 GIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-S 247
L+ ++D GD GDSGGPL+C+ +G+W Q GVVSWG+ CG+ +
Sbjct: 209 ------LKYSFRKD--IFGD--------MGDSGGPLACNKNGLWYQIGVVSWGVGCGRPN 252
Query: 248 LPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRP 291
PGVYTN+ ++ +WI +++ + + D +P++ L P
Sbjct: 253 RPGVYTNISHHFEWIQKLMAQ-SGMSQPDPSWPLLFFPLLWALP 295
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 180 bits (456), Expect = 2e-45
Identities = 97/255 (38%), Positives = 137/255 (53%), Gaps = 9/255 (3%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG+P S+R+VGG +A G WPWQVSLH ICGGSL++ +L+AAHC T
Sbjct: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
Query: 79 YTVWLGSITV----GDSRKRVKYYVSKIVIHPKYQ--DTTADVALLKLSSQVTFTSAILP 132
W + V G V+ IV+ Y + AD+ALL+L+S + A+ P
Sbjct: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWP 157
Query: 133 ICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFL 192
+CLP + + CW TGWG V+E+ LQE E+ ++ C+ LY+ G F
Sbjct: 158 VCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFN 217
Query: 193 PALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGV 251
L+ I +CAG + +D+C+GDSGGPL C G W Q G+ S+G CG ++ PGV
Sbjct: 218 LTLQ--ILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGV 275
Query: 252 YTNVIYYQKWINATI 266
+T V Y+ WI +
Sbjct: 276 FTAVATYEAWIREQV 290
Score = 87.0 bits (214), Expect = 2e-17
Identities = 75/242 (30%), Positives = 112/242 (46%), Gaps = 37/242 (15%)
Query: 39 WPWQVSLHFDHNFICGGSLVSERLILTAAHCI-QPTWTTFSY-TVWLGSITVGDSRKRVK 96
WPW +H + +C G L++ +L A HC+ +P TT Y V+LG G S
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLG--RAGASSLPQG 658
Query: 97 YYVSKIVIH---PKYQDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPP--FCWVT 151
+ VS++VI P++ +ALL+LSS+V + + LPICL IPP CWV
Sbjct: 659 HQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICL----HPAGIPPGASCWVL 714
Query: 152 GWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQN 211
GW KE DR A V I+ ++ C+ LY GI P +C +
Sbjct: 715 GW---KEPQDR----VPVAAAVSILTQRICDCLYQ--GILPPG--------TLCVLYAEG 757
Query: 212 MKDSCKGDSGGPLSCHI-DGVWIQTGVVSWGLECGKSLPGVYTNVIYYQKWINATISRAN 270
++ C+ S PL C + +G WI G+ G ++ + + WI+ T+ AN
Sbjct: 758 QENRCEMTSAPPLLCQMTEGSWILVGMAVQGSR------ELFAAIGPEEAWISQTVGEAN 811
Query: 271 NL 272
L
Sbjct: 812 FL 813
Score = 64.3 bits (155), Expect = 1e-10
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 11/217 (5%)
Query: 31 GQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITV-G 89
G+ G WPW+ + + C G+LVSE +L A C ++ S L + V
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
Query: 90 DSRKRVKYYVSKIVIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFC 148
SR R + V+++V H D +D+ALL+L + V ++A P+CLP C
Sbjct: 386 PSRPRAE-RVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRC 444
Query: 149 WVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKIC-AG 207
+ WG+ + + AL EAE ++ C LY G +P P +C A
Sbjct: 445 RLARWGRGEPALG---PGALLEAE--LLGGWWCHCLYGRQGAAVPL--PGDPPHALCPAY 497
Query: 208 DTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLEC 244
+ SC DS L C +G W G+ + C
Sbjct: 498 QEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 178 bits (451), Expect = 7e-45
Identities = 97/264 (36%), Positives = 137/264 (51%), Gaps = 17/264 (6%)
Query: 6 CAFTLLLLLGISVCGQPVYSSR---VVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERL 62
C+ ++ L CG + SSR +VGG+ A G WPWQVSLH + +CGGS+++
Sbjct: 268 CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEW 327
Query: 63 ILTAAHCIQ-PTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTA--DVALLK 119
I+TAAHC++ P + +T + G + Y V K++ HP Y T D+AL+K
Sbjct: 328 IVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMK 387
Query: 120 LSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQ 179
L +TF + P+CLP+ L CW++GWG +E L A+V +I+ Q
Sbjct: 388 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQ 445
Query: 180 ACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVS 239
C Y + PA+ ICAG Q DSC+GDSGGPL + +W G S
Sbjct: 446 RCNSRYVYDNLITPAM--------ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTS 497
Query: 240 WGLECGKSL-PGVYTNVIYYQKWI 262
WG C K+ PGVY NV+ + WI
Sbjct: 498 WGSGCAKAYRPGVYGNVMVFTDWI 521
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 178 bits (451), Expect = 7e-45
Identities = 97/264 (36%), Positives = 137/264 (51%), Gaps = 17/264 (6%)
Query: 6 CAFTLLLLLGISVCGQPVYSSR---VVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERL 62
C+ ++ L CG + SSR +VGG+ A G WPWQVSLH + +CGGS+++
Sbjct: 231 CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEW 290
Query: 63 ILTAAHCIQ-PTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTA--DVALLK 119
I+TAAHC++ P + +T + G + Y V K++ HP Y T D+AL+K
Sbjct: 291 IVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMK 350
Query: 120 LSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQ 179
L +TF + P+CLP+ L CW++GWG +E L A+V +I+ Q
Sbjct: 351 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQ 408
Query: 180 ACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVS 239
C Y + PA+ ICAG Q DSC+GDSGGPL + +W G S
Sbjct: 409 RCNSRYVYDNLITPAM--------ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTS 460
Query: 240 WGLECGKSL-PGVYTNVIYYQKWI 262
WG C K+ PGVY NV+ + WI
Sbjct: 461 WGSGCAKAYRPGVYGNVMVFTDWI 484
>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
Length = 275
Score = 176 bits (447), Expect = 2e-44
Identities = 96/256 (37%), Positives = 146/256 (57%), Gaps = 22/256 (8%)
Query: 20 GQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF---ICGGSLVSERLILTAAHCIQPTWTT 76
GQ + +VGGQ+A +WPWQVSL + CGGSL+ + +LTAAHC+ P
Sbjct: 23 GQALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDVKD 82
Query: 77 FSYTVWLGSITVGDSRKRVKYY------VSKIVIHPKYQDTT--ADVALLKLSSQVTFTS 128
L ++ V R++ YY VS+I++HP++ AD+ALL+L V +S
Sbjct: 83 ------LAALRV-QLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSS 135
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
+ + LP ++ CWVTGWG V L++ +VPI++ C+ Y+ +
Sbjct: 136 HVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYH-L 194
Query: 189 GIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-S 247
G + ++++D +CAG+T+ +DSC+GDSGGPL C ++G W+Q GVVSWG C + +
Sbjct: 195 GAYTGDDVRIVRDDMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPN 252
Query: 248 LPGVYTNVIYYQKWIN 263
PG+YT V YY WI+
Sbjct: 253 RPGIYTRVTYYLDWIH 268
>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
Length = 275
Score = 176 bits (445), Expect = 3e-44
Identities = 96/256 (37%), Positives = 146/256 (57%), Gaps = 22/256 (8%)
Query: 20 GQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF---ICGGSLVSERLILTAAHCIQPTWTT 76
GQ + +VGGQ+A +WPWQVSL + CGGSL+ + +LTAAHC+ P
Sbjct: 23 GQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKD 82
Query: 77 FSYTVWLGSITVGDSRKRVKYY------VSKIVIHPKYQDTT--ADVALLKLSSQVTFTS 128
L ++ V R++ YY VS+I++HP++ AD+ALL+L V +S
Sbjct: 83 ------LAALRV-QLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSS 135
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
+ + LP ++ CWVTGWG V L++ +VPI++ C+ Y+ +
Sbjct: 136 HVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYH-L 194
Query: 189 GIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-S 247
G + ++++D +CAG+T+ +DSC+GDSGGPL C ++G W+Q GVVSWG C + +
Sbjct: 195 GAYTGDDVRIVRDDMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPN 252
Query: 248 LPGVYTNVIYYQKWIN 263
PG+YT V YY WI+
Sbjct: 253 RPGIYTRVTYYLDWIH 268
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 174 bits (441), Expect = 1e-43
Identities = 95/260 (36%), Positives = 143/260 (55%), Gaps = 27/260 (10%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQP------ 72
CG SSR+VGG ++ G WPWQ SL ICGG+L+++R ++TAAHC Q
Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627
Query: 73 -TWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTT--ADVALLKLSSQVTFTSA 129
WT F VW S G+ V + VS++++HP +++ + DVALL+L V ++A
Sbjct: 628 VLWTVFLGKVWQNSRWPGE----VSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAA 683
Query: 130 ILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIG 189
+ P+CLP+ + CW+TGWG ++E +ALQ+ +V +I + C ++Y
Sbjct: 684 VRPVCLPARSHFFEPGLHCWITGWGALREGG--PISNALQKVDVQLIPQDLCSEVY---- 737
Query: 190 IFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCH-IDGVWIQTGVVSWGLECGK-S 247
+ +CAG + KD+C+GDSGGPL C + G W G+VSWGL CG+ +
Sbjct: 738 ------RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPN 791
Query: 248 LPGVYTNVIYYQKWINATIS 267
GVYT + WI ++
Sbjct: 792 YFGVYTRITGVISWIQQVVT 811
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 173 bits (439), Expect = 2e-43
Identities = 94/243 (38%), Positives = 138/243 (56%), Gaps = 18/243 (7%)
Query: 27 RVVGGQDAAAGRWPWQVSLHFD---HNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWL 83
R+VGG + G WPWQV+LH +CGGS++ + ILTAAHC + V+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
Query: 84 GSITVGDSRKRVKYY-VSKIVIHPKYQ--DTTADVALLKLSSQVTFTSAILPICLPSVTK 140
G + + ++ ++ V +I+IH +Y+ ++ D+ALLKL + V +T + PICLPS
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
Query: 141 QLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIK 200
+ I CWVTGWG ++ D+ + LQ+A++P++ + C++ Y I
Sbjct: 507 RNVIYTDCWVTGWG-YRKLRDK-IQNTLQKAKIPLVTNEECQKRYRG---------HKIT 555
Query: 201 EDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQ 259
ICAG + KD+CKGDSGGPLSC + VW G+ SWG C + PGVYTNV+ Y
Sbjct: 556 HKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYV 615
Query: 260 KWI 262
WI
Sbjct: 616 DWI 618
>gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]
Length = 410
Score = 173 bits (438), Expect = 2e-43
Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 18/261 (6%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG V SR++GG A +WPWQVSL + CGGSL+ R +LTAAHC+ F
Sbjct: 156 CGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCV------FR 207
Query: 79 YTVWLGS--ITVGDSRKRVKYYVSKIVIHPKYQD---TTADVALLKLSSQVTFTSAILPI 133
W G + G R + + +I P D T+D+AL L+ V ++S I P
Sbjct: 208 GCGWEGGRWLLAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPA 267
Query: 134 CLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLP 193
CLP ++ CWVTGWG+V ES LQE E+ I+ + C ++ I
Sbjct: 268 CLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNI--- 324
Query: 194 ALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVY 252
+ ++ +C + Q KD+C+GDSGGPL C ++G W+Q G+VSWG+ CG K PGVY
Sbjct: 325 SKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVY 383
Query: 253 TNVIYYQKWINATISRANNLD 273
T V +Y+KWI + +A+ L+
Sbjct: 384 TEVSFYKKWIIDHLRQASCLN 404
>gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo
sapiens]
Length = 410
Score = 173 bits (438), Expect = 2e-43
Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 18/261 (6%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG V SR++GG A +WPWQVSL + CGGSL+ R +LTAAHC+ F
Sbjct: 156 CGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCV------FR 207
Query: 79 YTVWLGS--ITVGDSRKRVKYYVSKIVIHPKYQD---TTADVALLKLSSQVTFTSAILPI 133
W G + G R + + +I P D T+D+AL L+ V ++S I P
Sbjct: 208 GCGWEGGRWLLAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPA 267
Query: 134 CLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLP 193
CLP ++ CWVTGWG+V ES LQE E+ I+ + C ++ I
Sbjct: 268 CLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNI--- 324
Query: 194 ALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVY 252
+ ++ +C + Q KD+C+GDSGGPL C ++G W+Q G+VSWG+ CG K PGVY
Sbjct: 325 SKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVY 383
Query: 253 TNVIYYQKWINATISRANNLD 273
T V +Y+KWI + +A+ L+
Sbjct: 384 TEVSFYKKWIIDHLRQASCLN 404
>gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo
sapiens]
Length = 410
Score = 173 bits (438), Expect = 2e-43
Identities = 100/261 (38%), Positives = 142/261 (54%), Gaps = 18/261 (6%)
Query: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
CG V SR++GG A +WPWQVSL + CGGSL+ R +LTAAHC+ F
Sbjct: 156 CGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCV------FR 207
Query: 79 YTVWLGS--ITVGDSRKRVKYYVSKIVIHPKYQD---TTADVALLKLSSQVTFTSAILPI 133
W G + G R + + +I P D T+D+AL L+ V ++S I P
Sbjct: 208 GCGWEGGRWLLAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPA 267
Query: 134 CLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLP 193
CLP ++ CWVTGWG+V ES LQE E+ I+ + C ++ I
Sbjct: 268 CLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNI--- 324
Query: 194 ALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVY 252
+ ++ +C + Q KD+C+GDSGGPL C ++G W+Q G+VSWG+ CG K PGVY
Sbjct: 325 SKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVY 383
Query: 253 TNVIYYQKWINATISRANNLD 273
T V +Y+KWI + +A+ L+
Sbjct: 384 TEVSFYKKWIIDHLRQASCLN 404
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 173 bits (438), Expect = 2e-43
Identities = 96/268 (35%), Positives = 144/268 (53%), Gaps = 14/268 (5%)
Query: 5 GCAFTLLLLLGISVCG-QPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLI 63
GCA ++ L + CG + YSSR+VGG + +WPWQ SL F +CGGS+++ I
Sbjct: 193 GCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI 252
Query: 64 LTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTA--DVALLKLS 121
+TAAHC+ + S+T+ +G +++ D+ + V KIV H KY+ D+AL+KL+
Sbjct: 253 ITAAHCVYDLYLPKSWTIQVGLVSLLDN-PAPSHLVEKIVYHSKYKPKRLGNDIALMKLA 311
Query: 122 SQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQAC 181
+TF I P+CLP+ + CW +GWG ++ + D L A VP+I + C
Sbjct: 312 GPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAG-DASPVLNHAAVPLISNKIC 370
Query: 182 EQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWG 241
GI P++ +CAG DSC+GDSGGPL C +W G S+G
Sbjct: 371 NHRDVYGGIISPSM--------LCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFG 422
Query: 242 LECGK-SLPGVYTNVIYYQKWINATISR 268
+ C + + PGVYT V + WI+ + R
Sbjct: 423 IGCAEVNKPGVYTRVTSFLDWIHEQMER 450
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 172 bits (437), Expect = 3e-43
Identities = 100/272 (36%), Positives = 143/272 (52%), Gaps = 27/272 (9%)
Query: 2 GPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFD---HNFICGGSLV 58
G +G + L SVC S+R+VGG +++ G WPWQVSL +CGGSL+
Sbjct: 366 GSSGYSLRLCNTGDNSVCTTKT-STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLI 424
Query: 59 SERLILTAAHC-----IQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQ--DT 111
+ +LTAAHC +Q W +S + L IT ++K +I+IH Y+ +
Sbjct: 425 GHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIK----EIIIHQNYKVSEG 480
Query: 112 TADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEA 171
D+AL+KL + + +T PICLPS I CWVTGWG KE + + LQ+
Sbjct: 481 NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGE--IQNILQKV 538
Query: 172 EVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGV 231
+P++ + C++ Y + I + +CAG + KD+CKGDSGGPL C +G+
Sbjct: 539 NIPLVTNEECQKRYQ---------DYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGM 589
Query: 232 WIQTGVVSWGLECG-KSLPGVYTNVIYYQKWI 262
W G+ SWG C + PGVYT V Y WI
Sbjct: 590 WRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 168 bits (425), Expect = 7e-42
Identities = 98/267 (36%), Positives = 143/267 (53%), Gaps = 26/267 (9%)
Query: 6 CAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILT 65
C + L S CG + R+VGG A+ +WPWQVSLHF ICGG+L+ + +LT
Sbjct: 304 CPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLT 363
Query: 66 AAHCIQPT-------WTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQD--TTADVA 116
AAHC T W ++ T L + S +++I+I+ Y D D+A
Sbjct: 364 AAHCFFVTREKVLEGWKVYAGTSNLHQLPEAAS-------IAEIIINSNYTDEEDDYDIA 416
Query: 117 LLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPII 176
L++LS +T ++ I P CLP + ++ CW+TG+GK +E+ D+ L+E +V +I
Sbjct: 417 LMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKT-SPFLREVQVNLI 475
Query: 177 DRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTG 236
D + C N ++ L P + +CAGD + +DSC+GDSGGPL C + W G
Sbjct: 476 DFKKC----NDYLVYDSYLTPRM----MCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAG 527
Query: 237 VVSWGLECG-KSLPGVYTNVIYYQKWI 262
V SWG CG ++ PGVYT V WI
Sbjct: 528 VTSWGTGCGQRNKPGVYTKVTEVLPWI 554
>gi|33186882 testis serine protease 2 [Homo sapiens]
Length = 293
Score = 166 bits (421), Expect = 2e-41
Identities = 91/223 (40%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 27 RVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSI 86
R+VGG DA GRWPWQVS+ ICGG+LV+ +LTA HCI + F Y+V +G
Sbjct: 79 RIVGGVDAEEGRWPWQVSVRTKGRHICGGTLVTATWVLTAGHCIS---SRFHYSVKMGDR 135
Query: 87 TVGDSRKRVKYYVSKIVIHPKYQDTTA---DVALLKLSSQVTFTSAILPICLPSVTKQLA 143
+V + V V + +HPK+ T D+ALL+L V FTS I PIC+P Q+
Sbjct: 136 SVYNENTSVVVSVQRAFVHPKFSTVTTIRNDLALLQLQHPVNFTSNIQPICIPQENFQVE 195
Query: 144 IPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDK 203
CWVTGWGK E ++ LQ+ + I+ + C ++ I L + + VI +
Sbjct: 196 GRTRCWVTGWGKTPE-REKLASEILQDVDQYIMCYEECNKI---IQKALSSTKDVIIKGM 251
Query: 204 ICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK 246
+C G + KDSC+GDSGG L+C + W+Q G+VSWG+ CG+
Sbjct: 252 VC-GYKEQGKDSCQGDSGGRLACEYNDTWVQVGIVSWGIGCGR 293
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 166 bits (419), Expect = 3e-41
Identities = 97/246 (39%), Positives = 132/246 (53%), Gaps = 23/246 (9%)
Query: 27 RVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTT--FSYTVWLG 84
R++GG D G WPWQVSLHF + CG S++S +L+AAHC + +T LG
Sbjct: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
Query: 85 SITVGDSRKRVKYYVSKIVIHPKYQDTT--ADVALLKLSS--QVTFTSAILPICLPSVTK 140
G++ + V +IV+H Y T D+ALL+LS T I PIC+P +
Sbjct: 539 MYVQGNA--KFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQ 596
Query: 141 QLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIK 200
++ CWVTGWG+ + +D LQ+AEV +ID+ C Y +I
Sbjct: 597 RVRSGEKCWVTGWGR-RHEADNKGSLVLQQAEVELIDQTLCVSTYG-----------IIT 644
Query: 201 EDKICAGDTQNMKDSCKGDSGGPLSCH--IDGVWIQTGVVSWGLECGK-SLPGVYTNVIY 257
+CAG +D+CKGDSGGPLSC DG WI TG+VSWG G+ + PGVYT V
Sbjct: 645 SRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSN 704
Query: 258 YQKWIN 263
+ WI+
Sbjct: 705 FVPWIH 710
>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
Length = 432
Score = 165 bits (417), Expect = 6e-41
Identities = 93/258 (36%), Positives = 132/258 (51%), Gaps = 12/258 (4%)
Query: 6 CAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILT 65
C L+ L CG+ + + RVVGG++A+ WPWQVS+ +D +CGGS++ +LT
Sbjct: 178 CLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLT 237
Query: 66 AAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKLSSQVT 125
AAHC + F++ V GS +G + I +P Y D+AL+KL +T
Sbjct: 238 AAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN-DIALMKLQFPLT 296
Query: 126 FTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLY 185
F+ + PICLP ++L W+ GWG K++ + L +A V +ID C
Sbjct: 297 FSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGK-MSDILLQASVQVIDSTRCNA-- 353
Query: 186 NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLEC- 244
A + + E +CAG + D+C+GDSGGPL D W G+VSWG C
Sbjct: 354 ------DDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCG 406
Query: 245 GKSLPGVYTNVIYYQKWI 262
G S PGVYT V Y WI
Sbjct: 407 GPSTPGVYTKVSAYLNWI 424
>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
sapiens]
Length = 437
Score = 165 bits (417), Expect = 6e-41
Identities = 93/258 (36%), Positives = 132/258 (51%), Gaps = 12/258 (4%)
Query: 6 CAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILT 65
C L+ L CG+ + + RVVGG++A+ WPWQVS+ +D +CGGS++ +LT
Sbjct: 183 CLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLT 242
Query: 66 AAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKLSSQVT 125
AAHC + F++ V GS +G + I +P Y D+AL+KL +T
Sbjct: 243 AAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN-DIALMKLQFPLT 301
Query: 126 FTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLY 185
F+ + PICLP ++L W+ GWG K++ + L +A V +ID C
Sbjct: 302 FSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGK-MSDILLQASVQVIDSTRCNA-- 358
Query: 186 NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLEC- 244
A + + E +CAG + D+C+GDSGGPL D W G+VSWG C
Sbjct: 359 ------DDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCG 411
Query: 245 GKSLPGVYTNVIYYQKWI 262
G S PGVYT V Y WI
Sbjct: 412 GPSTPGVYTKVSAYLNWI 429
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 160 bits (405), Expect = 1e-39
Identities = 97/266 (36%), Positives = 135/266 (50%), Gaps = 16/266 (6%)
Query: 6 CAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILT 65
C ++ L S CG +SR+VGGQ A GRWPWQ S+ CGGS+++ R ++T
Sbjct: 196 CTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVT 255
Query: 66 AAHCIQP--TWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKY--QDTTADVALLKLS 121
AAHC+ S+ V G ++ R V +I+ HP Y Q+ DVALL+L
Sbjct: 256 AAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQ 315
Query: 122 SQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHS-ALQEAEVPIIDRQA 180
+ + F+ + +CLP+ + CWV+GWG S Y S LQ+ VP+ Q
Sbjct: 316 TALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPS--HTYSSDMLQDTVVPLFSTQL 373
Query: 181 CEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSW 240
C N ++ AL P + +CAG D+C+GDSGGPL C W GVVSW
Sbjct: 374 C----NSSCVYSGALTPRM----LCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSW 425
Query: 241 GLECGK-SLPGVYTNVIYYQKWINAT 265
G C + + PGVY V + WI+ T
Sbjct: 426 GRGCAEPNHPGVYAKVAEFLDWIHDT 451
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 160 bits (405), Expect = 1e-39
Identities = 95/262 (36%), Positives = 145/262 (55%), Gaps = 21/262 (8%)
Query: 18 VCGQPVYSS-----RVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQP 72
VCG P +S R+ GG++A WPWQV L F ++ CGG++++ ILTAAHC+Q
Sbjct: 560 VCGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCVQL 619
Query: 73 TWTTFSYTVWLG--SITVGDSRKRVKYYVSKIVIHPKYQDTT--ADVALLKLSSQVTFTS 128
S+T+ G + +S ++V+ I++H + + +D+AL++LSS + + S
Sbjct: 620 KNNPLSWTIIAGDHDRNLKESTEQVR-RAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNS 678
Query: 129 AILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPI 188
+ P+CLP + L C VTGWG + S+D S LQ+ +V +++R+ CE Y
Sbjct: 679 VVRPVCLPHSAEPLFSSEICAVTGWGSI--SADGGLASRLQQIQVHVLEREVCEHTY--- 733
Query: 189 GIFLPALEPVIKEDKICAG-DTQNMKDSCKGDSGGPLSC-HIDGVWIQTGVVSWGLECGK 246
A I E ICAG KD C+GDSGGPL C H +G ++ G+VSWG C +
Sbjct: 734 ---YSAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQ 790
Query: 247 S-LPGVYTNVIYYQKWINATIS 267
PGV+ V+ + WI + I+
Sbjct: 791 PWKPGVFARVMIFLDWIQSKIN 812
Score = 140 bits (354), Expect = 1e-33
Identities = 84/234 (35%), Positives = 127/234 (54%), Gaps = 16/234 (6%)
Query: 24 YSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQ--PTWTTFSYTV 81
+ SR+ +++ PWQVSL D + CGGSL+ E ++TAAHC+ + TV
Sbjct: 43 FFSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITV 102
Query: 82 WLGSITVGDSRKRVKYY-VSKIVIHPKYQD---TTADVALLKLSSQVTFTSAILPICLPS 137
G ++ K+ + VSKI+ HP+Y + D+ALL L +V F +A+ PICLP
Sbjct: 103 TSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPD 162
Query: 138 VTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEP 197
++ C +GWGK+ ++S +Y + LQE E+PI+D +AC + + + P
Sbjct: 163 SDDKVEPGILCLSSGWGKISKTS--EYSNVLQEMELPIMDDRACNTVLKSMNL------P 214
Query: 198 VIKEDKICAGDTQNMKDSCKGDSGGPLSCHI-DGVWIQTGVVSWGLEC-GKSLP 249
+ +CAG D+C+GDSGGPL C G+WI G+ SW C G S+P
Sbjct: 215 PLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVP 268
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,230,965
Number of Sequences: 37866
Number of extensions: 577093
Number of successful extensions: 1846
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1134
Number of HSP's gapped (non-prelim): 186
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.