Guide to the Human Genome
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Search of human proteins with 148763345

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo
sapiens]
         (770 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]   1545   0.0  
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]   1532   0.0  
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1521   0.0  
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1514   0.0  
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1513   0.0  
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1445   0.0  
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1441   0.0  
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1042   0.0  
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      361   2e-99
gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta S...   312   9e-85
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      302   7e-82
gi|169161522 PREDICTED: similar to cell division cycle 2-like 1 ...   298   1e-80
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      290   5e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      288   2e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   270   4e-72
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        268   1e-71
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             253   6e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           251   2e-66
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    246   6e-65
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    246   6e-65
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   246   8e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   246   8e-65
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   242   8e-64
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   240   4e-63
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   239   9e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        237   3e-62
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          237   3e-62
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        233   4e-61
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]                   229   1e-59
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    228   2e-59

>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 1545 bits (4001), Expect = 0.0
 Identities = 770/770 (100%), Positives = 770/770 (100%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 120

Query: 121 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 180
           RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK
Sbjct: 121 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 180

Query: 181 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 240
           ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV
Sbjct: 181 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 240

Query: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 300
           KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 300

Query: 301 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 360
           EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE
Sbjct: 301 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 360

Query: 361 EAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE 420
           EAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE
Sbjct: 361 EAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE 420

Query: 421 EGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVV 480
           EGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVV
Sbjct: 421 EGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVV 480

Query: 481 GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKT 540
           GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKT
Sbjct: 481 GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKT 540

Query: 541 SNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVG 600
           SNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVG
Sbjct: 541 SNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVG 600

Query: 601 CIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLR 660
           CIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLR
Sbjct: 601 CIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLR 660

Query: 661 KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQ 720
           KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQ
Sbjct: 661 KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQ 720

Query: 721 RVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770
           RVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 RVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1532 bits (3967), Expect = 0.0
 Identities = 769/780 (98%), Positives = 769/780 (98%), Gaps = 10/780 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K 110
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 120

Query: 111 HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 170
           HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR
Sbjct: 121 HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 180

Query: 171 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 230
           EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER
Sbjct: 181 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 240

Query: 231 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 290
           FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
Sbjct: 241 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 300

Query: 291 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 350
           EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES
Sbjct: 301 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360

Query: 351 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSV 410
           RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSV
Sbjct: 361 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSV 420

Query: 411 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 470
           EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480

Query: 471 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 530
           NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540

Query: 531 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 590
           NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 600

Query: 591 STAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT 650
           STAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT 660

Query: 651 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF 710
           FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF
Sbjct: 661 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF 720

Query: 711 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770
           PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 780


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 1521 bits (3939), Expect = 0.0
 Identities = 764/772 (98%), Positives = 765/772 (99%), Gaps = 3/772 (0%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE--RE 118
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK KHARVKE  RE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-KHARVKEKERE 119

Query: 119 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 178
           HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE
Sbjct: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 179

Query: 179 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 238
           QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK
Sbjct: 180 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 239

Query: 239 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 298
           PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES
Sbjct: 240 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299

Query: 299 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 358
           EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE
Sbjct: 300 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 359

Query: 359 SEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNR 418
           SEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNR
Sbjct: 360 SEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNR 419

Query: 419 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI 478
           IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI
Sbjct: 420 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI 479

Query: 479 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL 538
           VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL
Sbjct: 480 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL 539

Query: 539 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWS 598
           KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWS
Sbjct: 540 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWS 599

Query: 599 VGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNN 658
           VGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNN
Sbjct: 600 VGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNN 659

Query: 659 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE 718
           LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE
Sbjct: 660 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE 719

Query: 719 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770
           QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 720 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 771


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 1514 bits (3919), Expect = 0.0
 Identities = 764/781 (97%), Positives = 765/781 (97%), Gaps = 12/781 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE--RE 118
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK KHARVKE  RE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-KHARVKEKERE 119

Query: 119 HERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQLERKRERERKM 169
           HERRKRHREEQDKARREWERQKRREMAREHSRRER         DRLEQLERKRERERKM
Sbjct: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKM 179

Query: 170 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 229
           REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE
Sbjct: 180 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 239

Query: 230 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 289
           RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE
Sbjct: 240 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 299

Query: 290 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 349
           EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE
Sbjct: 300 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 359

Query: 350 SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRS 409
           SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRS
Sbjct: 360 SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRS 419

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
           PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539

Query: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 589
           DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKE
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 599

Query: 590 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 649
           YSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKM
Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 659

Query: 650 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 709
           TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM
Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 719

Query: 710 FPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLK 769
           FPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLK
Sbjct: 720 FPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLK 779

Query: 770 F 770
           F
Sbjct: 780 F 780


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 1513 bits (3916), Expect = 0.0
 Identities = 763/782 (97%), Positives = 764/782 (97%), Gaps = 12/782 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK----------WK 110
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120

Query: 111 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 168
           HARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180

Query: 169 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 228
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240

Query: 229 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 288
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300

Query: 289 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 348
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360

Query: 349 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 408
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCR
Sbjct: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420

Query: 409 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 468
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480

Query: 469 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 528
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540

Query: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAK
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600

Query: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
           EYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKK
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660

Query: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 708
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720

Query: 709 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 768
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780

Query: 769 KF 770
           KF
Sbjct: 781 KF 782


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 1445 bits (3741), Expect = 0.0
 Identities = 726/738 (98%), Positives = 728/738 (98%), Gaps = 3/738 (0%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEKWKHARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRE 152
           EKVHHRKDEKRKEK KHARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRE
Sbjct: 61  EKVHHRKDEKRKEK-KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119

Query: 153 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 212
           RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD
Sbjct: 120 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 179

Query: 213 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 272
           KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA
Sbjct: 180 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 239

Query: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
           ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM
Sbjct: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299

Query: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392
           SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIE
Sbjct: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIE 359

Query: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452
           LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG
Sbjct: 360 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 419

Query: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
           FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
Sbjct: 420 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 479

Query: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572
           EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV
Sbjct: 480 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 539

Query: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632
           VVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTP
Sbjct: 540 VVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP 599

Query: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692
           SEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG
Sbjct: 600 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 659

Query: 693 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 752
           LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL
Sbjct: 660 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 719

Query: 753 TTTNQGASAAGPGFSLKF 770
           TTTNQGASAAGPGFSLKF
Sbjct: 720 TTTNQGASAAGPGFSLKF 737


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 1441 bits (3730), Expect = 0.0
 Identities = 726/748 (97%), Positives = 728/748 (97%), Gaps = 12/748 (1%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEK----------WKHARVKE--REHERRKRHREEQDKARREWERQKRR 142
           EKVHHRKDEKRKEK           KHARVKE  REHERRKRHREEQDKARREWERQKRR
Sbjct: 61  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120

Query: 143 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 202
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180

Query: 203 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 262
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240

Query: 263 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 322
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300

Query: 323 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 382
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360

Query: 383 PDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 442
           PDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 420

Query: 443 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 502
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 421 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 480

Query: 503 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 562
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 481 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 540

Query: 563 GSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQI 622
           GSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQI
Sbjct: 541 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 600

Query: 623 NKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 682
           NKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 601 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 660

Query: 683 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 742
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 661 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 720

Query: 743 DDLKETGFHLTTTNQGASAAGPGFSLKF 770
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 DDLKETGFHLTTTNQGASAAGPGFSLKF 748


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 1042 bits (2694), Expect = 0.0
 Identities = 521/526 (99%), Positives = 522/526 (99%)

Query: 245 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 304
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60

Query: 305 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 364
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120

Query: 365 EVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 424
           EVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180

Query: 425 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 484
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240

Query: 485 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 544
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300

Query: 545 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFG 604
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360

Query: 605 ELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFG 664
           ELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420

Query: 665 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 724
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480

Query: 725 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 770
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  361 bits (926), Expect = 2e-99
 Identities = 175/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)

Query: 407 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 466
           CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI  +L+
Sbjct: 33  CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92

Query: 467 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 526
            +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M  PF   +VK +++Q+LRG++
Sbjct: 93  LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152

Query: 527 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLG 586
           +LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P+K  TP VVT WYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212

Query: 587 AKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVV 646
               +T++DMW+VGCI  ELL  +PL PG SEI QI+ + + LGTPSE IWPG+S+LP+V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272

Query: 647 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 706
            + +  + PYNNL+ +F   LS+ G  L++    Y P +R +A D L+  YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331

Query: 707 PSMFPTWPAKSEQQRVKRGTSPRPPEG 733
           P + PT+P      R KR  +P   EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353


>gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta SV2
           [Homo sapiens]
          Length = 153

 Score =  312 bits (799), Expect = 9e-85
 Identities = 152/153 (99%), Positives = 152/153 (99%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMS KEKVHHRKDEKRKEKWKHARVKEREHE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEKWKHARVKEREHE 120

Query: 121 RRKRHREEQDKARREWERQKRREMAREHSRRER 153
           RRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 121 RRKRHREEQDKARREWERQKRREMAREHSRRER 153


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  302 bits (774), Expect = 7e-82
 Identities = 147/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)

Query: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 505
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 506 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 565
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 566 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 625
           +K  TP VVT WYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 626 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 685
            + LGTPSE IWPG+S+LP+V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 686 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 733
           R +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282


>gi|169161522 PREDICTED: similar to cell division cycle 2-like 1
           (PITSLRE proteins) [Homo sapiens]
          Length = 155

 Score =  298 bits (764), Expect = 1e-80
 Identities = 150/155 (96%), Positives = 150/155 (96%), Gaps = 2/155 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARV--KERE 118
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK HHRKDEKRKEK KHARV  KERE
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRKHARVKEKERE 120

Query: 119 HERRKRHREEQDKARREWERQKRREMAREHSRRER 153
           HERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 121 HERRKRHREEQDKARREWERQKRREMAREHSRRER 155



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 33/168 (19%), Positives = 67/168 (39%), Gaps = 18/168 (10%)

Query: 160 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 219
           E+   + + + E  +E++ +KE+E +AE +R +    R+      + R+   +     H 
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD------SKRDSLEEGELRDH- 56

Query: 220 SRSPPRPPRERFELGDGRKPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 278
                     R E+     P + E+ ME+R    D   I   ++ +   ++   +     
Sbjct: 57  ----------RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRK 106

Query: 279 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 326
           E+ +    +E+E      +   EE+++   E E     E A E S  E
Sbjct: 107 EKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 18/156 (11%)

Query: 156 LEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 215
           L++ +R++E+E K   ++ +  + ++ +R + E  + R+ R E++  +   R + S + +
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76

Query: 216 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 275
                    +PP++           ++EK   R          D +RK     +   E  
Sbjct: 77  GEEDDSLAIKPPQQM---------SRKEKAHHR---------KDEKRKEKRKHARVKEKE 118

Query: 276 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 311
              E  +   EE+++     E  +  E   E    E
Sbjct: 119 REHERRKRHREEQDKARREWERQKRREMAREHSRRE 154


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  290 bits (741), Expect = 5e-78
 Identities = 144/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)

Query: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 505
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 506 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 565
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 566 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 625
           +K  TP VVT WYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 626 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 685
            + LGTPSE IWPG+S+LP+V + +  + PYNNL+ +F   LS+ G  L++         
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233

Query: 686 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 733
             +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  288 bits (736), Expect = 2e-77
 Identities = 136/258 (52%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 505
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 506 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 565
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 566 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 625
           +K  TP VVT WYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 626 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 685
            + LGTPSE IWPG+S+LP+V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 686 RISAEDGLKHEYFRETPL 703
           R +A D L+  YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  270 bits (690), Expect = 4e-72
 Identities = 135/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           ++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 528
           PNIV + ++V   N  K+Y+V  ++  DLK  M++     LP   +K+ + QLL+GV   
Sbjct: 61  PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118

Query: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588
           H + ++HRDLK  NLL++  G +K+ DFGLAR +G PL+ YT  VVT WYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
            Y+TAVD+WS+GCIF E++T+K LFPG+SEIDQ+ ++F+ LGTPSE  WPG ++LP  K 
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238

Query: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 698
            +F +     L +     L  +G DL+ + L Y P +RI+A+  L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  268 bits (686), Expect = 1e-71
 Identities = 132/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 528
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118

Query: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVT WYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178

Query: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
            YSTAVD+WS+GCIF E++T++ LFPG+SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238

Query: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 705
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  253 bits (645), Expect = 6e-67
 Identities = 123/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 523
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 524 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPEL 583
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT  VVT WYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174

Query: 584 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSEL 643
           LLG+  YST VD+WS+G IF EL T+KPLF G+SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 644 PVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 700
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  251 bits (640), Expect = 2e-66
 Identities = 121/297 (40%), Positives = 196/297 (65%), Gaps = 14/297 (4%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 523
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 524 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPEL 583
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT   +T WYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174

Query: 584 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSEL 643
           LLG+  YST VD+WS+G IF EL T+KPLF G+SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 644 PVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 700
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  246 bits (628), Expect = 6e-65
 Identities = 209/769 (27%), Positives = 332/769 (43%), Gaps = 81/769 (10%)

Query: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325

Query: 83   LAIKPPQQMSRKEKV----------HHRKDEKRKEKWKHARV----KEREHER------- 121
                   Q  R  K           + R+  +    +   R     +   +ER       
Sbjct: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385

Query: 122  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 173
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442

Query: 174  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 233
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502

Query: 234  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 286
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562

Query: 287  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 338
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622

Query: 339  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 392
            ++    + V   +      E E+    +    P    L  GD +  SP        L  +
Sbjct: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677

Query: 393  LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 445
             + ++  P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737

Query: 446  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 497
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 498  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 557
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 558  LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 616
            LAR Y S   + YT  V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 617  SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 676
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976

Query: 677  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 724
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 139 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 192
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 193 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 237
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 358 ES 359
           +S
Sbjct: 408 KS 409



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 39/172 (22%), Positives = 63/172 (36%), Gaps = 22/172 (12%)

Query: 76  RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARRE 135
           RGE  +    +  +  S + K  HR + +R++  +      +   R     EE+ +  + 
Sbjct: 190 RGEGSERRPRRDRRSSSGRSKERHR-EHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 136 WE------RQKRREMAREHSRRERDRLEQLERKRERERK-----MREQQKEQREQKERER 184
                   R+K        S   +DR  +  R R +  K      +E  K  RE K  E 
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK-TEP 307

Query: 185 RAEERRKERE---ARREVSAHHRTMREDYSDKVK------ASHWSRSPPRPP 227
           +A  RR+       R +    HR  +   S K        +S +SR  PR P
Sbjct: 308 KAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  246 bits (628), Expect = 6e-65
 Identities = 209/769 (27%), Positives = 332/769 (43%), Gaps = 81/769 (10%)

Query: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325

Query: 83   LAIKPPQQMSRKEKV----------HHRKDEKRKEKWKHARV----KEREHER------- 121
                   Q  R  K           + R+  +    +   R     +   +ER       
Sbjct: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385

Query: 122  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 173
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442

Query: 174  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 233
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502

Query: 234  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 286
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562

Query: 287  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 338
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622

Query: 339  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 392
            ++    + V   +      E E+    +    P    L  GD +  SP        L  +
Sbjct: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677

Query: 393  LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 445
             + ++  P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737

Query: 446  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 497
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 498  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 557
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 558  LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 616
            LAR Y S   + YT  V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 617  SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 676
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976

Query: 677  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 724
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 139 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 192
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 193 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 237
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 358 ES 359
           +S
Sbjct: 408 KS 409



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 39/172 (22%), Positives = 63/172 (36%), Gaps = 22/172 (12%)

Query: 76  RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARRE 135
           RGE  +    +  +  S + K  HR + +R++  +      +   R     EE+ +  + 
Sbjct: 190 RGEGSERRPRRDRRSSSGRSKERHR-EHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 136 WE------RQKRREMAREHSRRERDRLEQLERKRERERK-----MREQQKEQREQKERER 184
                   R+K        S   +DR  +  R R +  K      +E  K  RE K  E 
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK-TEP 307

Query: 185 RAEERRKERE---ARREVSAHHRTMREDYSDKVK------ASHWSRSPPRPP 227
           +A  RR+       R +    HR  +   S K        +S +SR  PR P
Sbjct: 308 KAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 358  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALLPIELKQELPKYLPAL------------ 404
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 405  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 462
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 463  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 514
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 515  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 573
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 574  VTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPS 633
            +T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 634  EKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 693
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 694  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 726
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 727  -------SPRPPEGGLGYSQLGDDD 744
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 59/301 (19%), Positives = 106/301 (35%), Gaps = 27/301 (8%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHCMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K   
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK--- 90

Query: 90  QMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKAR-REWERQKRREMAREH 148
            + R+E    R  ++     KH         R  +HR  +D  + ++ E++K +E++ + 
Sbjct: 91  -LDRRENDERRGSDRSDRLHKH---------RHHQHRRSRDLLKAKQTEKEKSQEVSSK- 139

Query: 149 SRRERDRLEQLERKRERER----KMREQQKEQREQKERERRAEERRKEREAR-----REV 199
           S   +DR+    ++   E     K +  +   +E +  +   E+ RKERE +     R  
Sbjct: 140 SGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSK 199

Query: 200 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 259
           S   R   + Y         SRSP R   +  +  D   P      ++ DL       S 
Sbjct: 200 SHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD--SPSGASYGQDYDLSPSRSHTSS 257

Query: 260 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 319
           +      +  S++   S S   +E    +    S S  S  +          + S     
Sbjct: 258 NYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSG 317

Query: 320 S 320
           S
Sbjct: 318 S 318



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 52/231 (22%), Positives = 90/231 (38%), Gaps = 31/231 (13%)

Query: 75  DRGEEDDSLAIKPPQQMSRKEKVHHRKDE-----KRKEKWKHARV-------KEREHERR 122
           DR E D+        ++ +     HR+       K+ EK K   V       K+R     
Sbjct: 92  DRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSS 151

Query: 123 KRHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ 176
           KR  EE D       A+   +  +  ++ +E +R+ER+ L+   + R +  + RE  K  
Sbjct: 152 KRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSY 210

Query: 177 R--EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERF 231
           +  +  +R  R+  R+    ++++ S    +  +DY      SH S    S  + P    
Sbjct: 211 KTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS 270

Query: 232 ELGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 275
                  P KE    +    S        + +S  S R++SS E S + SG
Sbjct: 271 RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 358  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALLPIELKQELPKYLPAL------------ 404
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 405  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 462
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 463  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 514
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 515  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 573
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 574  VTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPS 633
            +T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 634  EKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 693
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 694  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 726
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 727  -------SPRPPEGGLGYSQLGDDD 744
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 59/301 (19%), Positives = 106/301 (35%), Gaps = 27/301 (8%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHCMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K   
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK--- 90

Query: 90  QMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKAR-REWERQKRREMAREH 148
            + R+E    R  ++     KH         R  +HR  +D  + ++ E++K +E++ + 
Sbjct: 91  -LDRRENDERRGSDRSDRLHKH---------RHHQHRRSRDLLKAKQTEKEKSQEVSSK- 139

Query: 149 SRRERDRLEQLERKRERER----KMREQQKEQREQKERERRAEERRKEREAR-----REV 199
           S   +DR+    ++   E     K +  +   +E +  +   E+ RKERE +     R  
Sbjct: 140 SGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSK 199

Query: 200 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 259
           S   R   + Y         SRSP R   +  +  D   P      ++ DL       S 
Sbjct: 200 SHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD--SPSGASYGQDYDLSPSRSHTSS 257

Query: 260 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 319
           +      +  S++   S S   +E    +    S S  S  +          + S     
Sbjct: 258 NYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSG 317

Query: 320 S 320
           S
Sbjct: 318 S 318



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 52/231 (22%), Positives = 90/231 (38%), Gaps = 31/231 (13%)

Query: 75  DRGEEDDSLAIKPPQQMSRKEKVHHRKDE-----KRKEKWKHARV-------KEREHERR 122
           DR E D+        ++ +     HR+       K+ EK K   V       K+R     
Sbjct: 92  DRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSS 151

Query: 123 KRHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ 176
           KR  EE D       A+   +  +  ++ +E +R+ER+ L+   + R +  + RE  K  
Sbjct: 152 KRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSY 210

Query: 177 R--EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERF 231
           +  +  +R  R+  R+    ++++ S    +  +DY      SH S    S  + P    
Sbjct: 211 KTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS 270

Query: 232 ELGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 275
                  P KE    +    S        + +S  S R++SS E S + SG
Sbjct: 271 RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  242 bits (618), Expect = 8e-64
 Identities = 130/336 (38%), Positives = 200/336 (59%), Gaps = 16/336 (4%)

Query: 411 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 467
           + ++ L+ + EG +  VY+A+DK T++IVA+K++K+    + K+G   T+LREI  + + 
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 468 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 527
            HPNI+ + +     +   I +V +++E DL+ +++       P  +K  M+  L+G+++
Sbjct: 70  SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 528 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGA 587
           LH +WILHRDLK +NLLL   G+LK+ DFGLA+ +GSP +AYT  VVT+WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 588 KEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVK 647
           + Y   VDMW+VGCI  ELL + P  PG+S++DQ+ ++F+ LGTP+E+ WP    LP   
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245

Query: 648 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 707
            +TF   P   L   F A   D   DL+     + P  RI+A   LK +YF   P P   
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304

Query: 708 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 735
                P  P ++ +++      +KR  +    +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  240 bits (612), Expect = 4e-63
 Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           +++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI  + + +H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
            NIV + +++      K+ +V  + + DLK   ++      P  VK+ + QLL+G+   H
Sbjct: 61  KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118

Query: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 589
              +LHRDLK  NLL++  G LK+ DFGLAR +G P++ Y+  VVT WYR P++L GAK 
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 590 YSTAVDMWSVGCIFGELLTQ-KPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
           YST++DMWS GCIF EL    +PLFPGN   DQ+ ++F+ LGTP+E+ WP  ++LP  K 
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237

Query: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 700
             +  +P           L+  G DL+   L   P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  239 bits (609), Expect = 9e-63
 Identities = 124/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 465
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243

Query: 466 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 524
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 525 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELL 584
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVT WYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 585 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELP 644
           LG+ EYST +DMW VGCIF E+ + +PLFPG++  D+++ +F+ LGTPS++ WPG S   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 645 VVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  237 bits (604), Expect = 3e-62
 Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)

Query: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100

Query: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392
           S    R   +    +  S  D +   S  A+  + EG  +   LT    + D P      
Sbjct: 101 SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 150

Query: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452
           L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E EG
Sbjct: 151 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 209

Query: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
            P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++         
Sbjct: 210 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 267

Query: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572
            VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  
Sbjct: 268 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 327

Query: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632
           VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++  +Q++ +F+ LGTP
Sbjct: 328 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 387

Query: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692
           +E+ WPG       K   + ++    L      L SD G DL+ K L +    RISAED 
Sbjct: 388 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 446

Query: 693 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 727
           +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 447 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  237 bits (604), Expect = 3e-62
 Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)

Query: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 35  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94

Query: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392
           S    R   +    +  S  D +   S  A+  + EG  +   LT    + D P      
Sbjct: 95  SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 144

Query: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452
           L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E EG
Sbjct: 145 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 203

Query: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
            P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++         
Sbjct: 204 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 261

Query: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572
            VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  
Sbjct: 262 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 321

Query: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632
           VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++  +Q++ +F+ LGTP
Sbjct: 322 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 381

Query: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692
           +E+ WPG       K   + ++    L      L SD G DL+ K L +    RISAED 
Sbjct: 382 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 440

Query: 693 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 727
           +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 441 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  233 bits (595), Expect = 4e-61
 Identities = 126/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)

Query: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
           ++++  L RI EG +G+V++AK  +T EIVALK++ + + ++GFP  +LREI   L+   
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59

Query: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
            N   V+   V  +     +   ++  DL  ++   ++P    +VK+ +  LL+GV   H
Sbjct: 60  DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTQWYRAPELLLGAK 588
            N I+HRDLK +NLL+S +G LK+ DFGLAR +     + YT  V T+WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648
           +Y   VD+WSVGCI GELL   PLFPG ++I+Q+  V + LGTP+ ++WP  +ELP   K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 708
           ++F E     L +     +S Q  DL+ +FL Y P +RI+A   L H+YF   PLP  PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298

Query: 709 MFP 711
             P
Sbjct: 299 ELP 301


>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
          Length = 372

 Score =  229 bits (583), Expect = 1e-59
 Identities = 117/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)

Query: 407 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 466
           C  V +++ L +I +GT+G V++A+ +KT + VALK++ ME EKEGFPIT+LREI  +  
Sbjct: 13  CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72

Query: 467 AQHPNIVTVREIV------VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQ 520
            +H N+V + EI              IY+V ++ EHDL  L+  +   F   E+K +M  
Sbjct: 73  LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132

Query: 521 LLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYG----SPLKAYTPVVVTQ 576
           LL G+ ++H N ILHRD+K +N+L++  G+LK+ DFGLAR +     S    YT  VVT 
Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192

Query: 577 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKI 636
           WYR PELLLG ++Y   +D+W  GCI  E+ T+ P+  GN+E  Q+  + +  G+ + ++
Sbjct: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252

Query: 637 WPGYSELPVVKKMTFSEHPYNNLRKRFGALLSD-QGFDLMNKFLTYFPGRRISAEDGLKH 695
           WP      + +K+   +     ++ R  A + D    DL++K L   P +RI ++D L H
Sbjct: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312

Query: 696 EYFRETPLPID 706
           ++F   P+P D
Sbjct: 313 DFFWSDPMPSD 323


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  228 bits (580), Expect = 2e-59
 Identities = 121/294 (41%), Positives = 175/294 (59%), Gaps = 5/294 (1%)

Query: 411 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 470
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 471 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 530
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231

Query: 531 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 590
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVT WYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291

Query: 591 STAVDMWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKM 649
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351

Query: 650 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 702
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.129    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,506,478
Number of Sequences: 37866
Number of extensions: 1936638
Number of successful extensions: 136038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2629
Number of HSP's successfully gapped in prelim test: 1492
Number of HSP's that attempted gapping in prelim test: 18680
Number of HSP's gapped (non-prelim): 33572
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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