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Search of human proteins with 148612829
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
(1006 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 2058 0.0
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 2035 0.0
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 1199 0.0
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 1179 0.0
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 1138 0.0
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 1123 0.0
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 129 2e-29
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 129 2e-29
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 129 2e-29
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 115 2e-25
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 114 5e-25
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 110 5e-24
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 60 1e-08
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 56 2e-07
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 56 2e-07
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 56 2e-07
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 51 6e-06
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 49 2e-05
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 46 2e-04
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 44 0.001
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 44 0.001
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 40 0.008
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 39 0.019
gi|116292170 RUN domain containing 2A [Homo sapiens] 39 0.025
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 39 0.032
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 38 0.055
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 38 0.055
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 38 0.055
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 38 0.055
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 38 0.055
>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1006
Score = 2058 bits (5333), Expect = 0.0
Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)
Query: 1 MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA
Sbjct: 1 MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
Query: 61 GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP
Sbjct: 61 GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
Query: 121 ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA
Sbjct: 121 ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
Query: 181 LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA
Sbjct: 181 LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
Query: 241 ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN
Sbjct: 241 ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
Query: 301 GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL
Sbjct: 301 GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
Query: 361 LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI
Sbjct: 361 LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
Query: 421 IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPD 480
IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPD
Sbjct: 421 IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPD 480
Query: 481 RLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTK 540
RLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTK
Sbjct: 481 RLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTK 540
Query: 541 DVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVA 600
DVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVA
Sbjct: 541 DVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVA 600
Query: 601 ARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISV 660
ARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISV
Sbjct: 601 ARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISV 660
Query: 661 DDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQ 720
DDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQ
Sbjct: 661 DDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQ 720
Query: 721 SSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAA 780
SSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAA
Sbjct: 721 SSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAA 780
Query: 781 AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMC 840
AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMC
Sbjct: 781 AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMC 840
Query: 841 DLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMH 900
DLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMH
Sbjct: 841 DLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMH 900
Query: 901 QNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYRE 960
QNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYRE
Sbjct: 901 QNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYRE 960
Query: 961 IIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
IIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK
Sbjct: 961 IIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1051
Score = 2035 bits (5272), Expect = 0.0
Identities = 1005/1051 (95%), Positives = 1006/1051 (95%), Gaps = 45/1051 (4%)
Query: 1 MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA
Sbjct: 1 MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
Query: 61 GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP
Sbjct: 61 GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
Query: 121 ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA
Sbjct: 121 ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
Query: 181 LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA
Sbjct: 181 LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
Query: 241 ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN
Sbjct: 241 ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
Query: 301 GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL
Sbjct: 301 GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
Query: 361 LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI
Sbjct: 361 LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
Query: 421 IYPGHRHEH---------------------------------------------NAGDMI 435
IYPGHRHEH +AGDMI
Sbjct: 421 IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480
Query: 436 EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 495
EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI
Sbjct: 481 EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540
Query: 496 VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 555
VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE
Sbjct: 541 VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600
Query: 556 LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 615
LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV
Sbjct: 601 LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 660
Query: 616 VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 675
VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR
Sbjct: 661 VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 720
Query: 676 PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 735
PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED
Sbjct: 721 PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 780
Query: 736 GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 795
GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH
Sbjct: 781 GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 840
Query: 796 RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855
RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL
Sbjct: 841 RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900
Query: 856 AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 915
AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF
Sbjct: 901 AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 960
Query: 916 LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 975
LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF
Sbjct: 961 LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 1020
Query: 976 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
FNERAEHHDAQEILRIARDLVHKVQMLIENK
Sbjct: 1021 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 1199 bits (3102), Expect = 0.0
Identities = 631/1098 (57%), Positives = 764/1098 (69%), Gaps = 105/1098 (9%)
Query: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
Query: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS
Sbjct: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
Query: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
Query: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A
Sbjct: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241
Query: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
Query: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL
Sbjct: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
Query: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420
FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI
Sbjct: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
Query: 421 IYPGHRHEHNAGDMIEMQGFG-PSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIP 479
IYPG + E D++++ PSL W P + SSC SCS S S + ++ C
Sbjct: 422 IYPGMQSEFVPQDLMDVSVSNLPSL--WQPSP---RKSSCSSCSQSGSADGSSTN-GCNH 475
Query: 480 DRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLT 539
+R PL+LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT
Sbjct: 476 ERAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLT 535
Query: 540 KDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVV 599
+W +Y D +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD +
Sbjct: 536 ARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQI 595
Query: 600 AARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTI------- 652
A Y Q +AEW CE +VRQRERE+H A K SSG+S+DSH+ R++HRDSTI
Sbjct: 596 HACYAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQS 655
Query: 653 ----------------SNDVFISVDDLEPPEPQDP-EDSRPK------------------ 677
S VF SVD++E E + E+ +PK
Sbjct: 656 CSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHP 715
Query: 678 ----------PEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQS------ 721
E T + + Q+++ P G R S A+ Q
Sbjct: 716 SSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREE 775
Query: 722 ---------------SLDEGQSV------GFEEEDGGGEEGSSGPGPAAHTLREPQDPSQ 760
S+DE S+ E+D EG H + +D
Sbjct: 776 LAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLS 835
Query: 761 EKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNY 808
E+P+ L AV +A Y+ ELLD +NLHRI+KDVQRCDRNY
Sbjct: 836 EEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNY 895
Query: 809 WYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMS 868
WYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+
Sbjct: 896 WYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMN 955
Query: 869 QNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDV 928
QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DV
Sbjct: 956 QNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDV 1015
Query: 929 FAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEI 988
F VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++
Sbjct: 1016 FLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQV 1075
Query: 989 LRIARDLVHKVQMLIENK 1006
L++ARDLV+KVQ LIENK
Sbjct: 1076 LKLARDLVYKVQTLIENK 1093
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 1179 bits (3050), Expect = 0.0
Identities = 632/1151 (54%), Positives = 763/1151 (66%), Gaps = 156/1151 (13%)
Query: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
Query: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS
Sbjct: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
Query: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
Query: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A
Sbjct: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241
Query: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
Query: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL
Sbjct: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
Query: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420
FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI
Sbjct: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
Query: 421 IYPGHRHEHNA------------------------------GDMIEMQGFGPSLPA---- 446
IYPG + E A G E + +LP
Sbjct: 422 IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPK 481
Query: 447 --------------------WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRL 486
W P + SSC SCS S S + ++ C +R PL+L
Sbjct: 482 EQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPLKL 537
Query: 487 LCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKY 546
LC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT +W +Y
Sbjct: 538 LCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQY 597
Query: 547 QKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 606
D +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD + A Y Q
Sbjct: 598 LHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQT 657
Query: 607 LAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTI-------------- 652
+AEW CE +VRQRERE+H A K SSG+S+DSH+ R++HRDSTI
Sbjct: 658 MAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQN 717
Query: 653 ---------SNDVFISVDDLEPPEPQDP-EDSRPK------------------------- 677
S VF SVD++E E + E+ +PK
Sbjct: 718 IRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSS 777
Query: 678 ---PEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQS------------- 721
E T + + Q+++ P G R S A+ Q
Sbjct: 778 GLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSL 837
Query: 722 --------SLDEGQSV------GFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGE 767
S+DE S+ E+D EG H + +D E+P+
Sbjct: 838 ESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMES 897
Query: 768 LEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPN 815
L AV +A Y+ ELLD +NLHRI+KDVQRCDRNYWYFTP N
Sbjct: 898 LFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPAN 957
Query: 816 LERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGG 875
LE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+QNFP+GG
Sbjct: 958 LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGG 1017
Query: 876 AMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVI 935
AMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DVF VWE I
Sbjct: 1018 AMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETI 1077
Query: 936 WAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995
WAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++L++ARDL
Sbjct: 1078 WAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1137
Query: 996 VHKVQMLIENK 1006
V+KVQ LIENK
Sbjct: 1138 VYKVQTLIENK 1148
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 1138 bits (2943), Expect = 0.0
Identities = 601/1051 (57%), Positives = 736/1051 (70%), Gaps = 72/1051 (6%)
Query: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
Query: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS
Sbjct: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
Query: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
Query: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A
Sbjct: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGS-MDDRPSLSA 241
Query: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
Query: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL
Sbjct: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
Query: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVD--MEEMGTGRATDYVFRI 420
FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI
Sbjct: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
Query: 421 IYPGHRHEHNAGDMIEMQGFG-PSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIP 479
IYPG + E D++++ PSL W P + SSC SCS S S + ++ C
Sbjct: 422 IYPGMQSEFVPQDLMDVSVSNLPSL--WQPSP---RKSSCSSCSQSGSADGSSTN-GCNH 475
Query: 480 DRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLT 539
+R PL+LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT
Sbjct: 476 ERAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLT 535
Query: 540 KDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVV 599
+W +Y D +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++
Sbjct: 536 ARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSC 595
Query: 600 AARYQQV---------------LAEWKACEVVVRQRERE-----------------AHPA 627
++ Q + + E + E R E++ HP+
Sbjct: 596 SSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPS 655
Query: 628 TRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTP 687
+ FSSG S H + ++S + + P P D Q + T
Sbjct: 656 SH-NFSSGLS--------EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTS 706
Query: 688 GTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGP 747
++ +V+ DS +S L ++ + I SLD + E+D EG
Sbjct: 707 QDEAPREELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSET 761
Query: 748 AAHTLREPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLH 795
H + +D E+P+ L AV +A Y+ ELLD +NLH
Sbjct: 762 EKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLH 821
Query: 796 RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855
RI+KDVQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ L
Sbjct: 822 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEAL 881
Query: 856 AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 915
A+SCF+ LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF
Sbjct: 882 AFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 941
Query: 916 LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 975
LLDFKREL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKF
Sbjct: 942 LLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKF 1001
Query: 976 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
FNE AE H+ +++L++ARDLV+KVQ LIENK
Sbjct: 1002 FNEMAERHNTKQVLKLARDLVYKVQTLIENK 1032
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 1123 bits (2905), Expect = 0.0
Identities = 602/1101 (54%), Positives = 737/1101 (66%), Gaps = 117/1101 (10%)
Query: 4 AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
AE +++LL VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
Query: 64 RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
RS+K+AALF KVGK P A ++ KVQ+L+Q E + + L+ K P LS
Sbjct: 66 RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
Query: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
Query: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
TK+KTADH+WTDPSADELVQRHRI RQDSP KRPAL I+KRHSSGS +DR + A
Sbjct: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGS-MDDRPSLSA 241
Query: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
R+ VESLHQNSR LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
Query: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
GD + EKSVYWDYA+ + ++V +HCHQQ SGGT+VLVSQDGIQRPP FP+GGHLL
Sbjct: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
Query: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVD--MEEMGTGRATDYVFRI 420
FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS S + + ATDYVFRI
Sbjct: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
Query: 421 IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEP------LCSQGS----------------- 457
IYPG + E A D + PAW + P + ++GS
Sbjct: 422 IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPK 481
Query: 458 ----------------------------SCLSCSSSSSPHATPSHCSCIPDRLPLRLLCE 489
SC SCS S S + ++ C +R PL+LLC+
Sbjct: 482 EQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTN-GCNHERAPLKLLCD 540
Query: 490 SMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKD 549
+MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P A GLT +W +Y D
Sbjct: 541 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
Query: 550 KKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV--- 606
+Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++ ++ Q +
Sbjct: 601 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 660
Query: 607 ------------LAEWKACEVVVRQRERE-----------------AHPATRTKFSSGSS 637
+ E + E R E++ HP++ FSSG S
Sbjct: 661 SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSH-NFSSGLS 719
Query: 638 IDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHS 697
H + ++S + + P P D Q + T ++ +
Sbjct: 720 --------EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELA 771
Query: 698 VEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQD 757
V+ DS +S L ++ + I SLD + E+D EG H + +D
Sbjct: 772 VQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQADSED 826
Query: 758 PSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCD 805
E+P+ L AV +A Y+ ELLD +NLHRI+KDVQRCD
Sbjct: 827 NLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCD 886
Query: 806 RNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK 865
RNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMK
Sbjct: 887 RNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMK 946
Query: 866 RMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLY 925
RM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y
Sbjct: 947 RMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVY 1006
Query: 926 EDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDA 985
+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+
Sbjct: 1007 DDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNT 1066
Query: 986 QEILRIARDLVHKVQMLIENK 1006
+++L++ARDLV+KVQ LIENK
Sbjct: 1067 KQVLKLARDLVYKVQTLIENK 1087
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 129 bits (323), Expect = 2e-29
Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)
Query: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
I+KDV R DR ++ P L L D++ +Y D+GYVQGM DLL+PLL ++N+
Sbjct: 402 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461
Query: 854 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912
A+ CF+ M +M QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 462 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520
Query: 913 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972
RW L+ FKRE + D+ +WEV+W + +F L + A++E+ ++ I + + F +I
Sbjct: 521 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 578
Query: 973 IKFFNERAEHHDAQEIL 989
+K NE + D ++IL
Sbjct: 579 LKHINELSMKIDVEDIL 595
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 543 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 601
W+K + ++ ++Q ++ GG+ H +RK W FLLG++ + +K+E Q+
Sbjct: 313 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 372
Query: 602 RYQQVLAEWKA 612
Y ++ +WK+
Sbjct: 373 EYFRMKLQWKS 383
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 129 bits (323), Expect = 2e-29
Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)
Query: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
I+KDV R DR ++ P L L D++ +Y D+GYVQGM DLL+PLL ++N+
Sbjct: 416 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 475
Query: 854 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912
A+ CF+ M +M QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 476 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 534
Query: 913 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972
RW L+ FKRE + D+ +WEV+W + +F L + A++E+ ++ I + + F +I
Sbjct: 535 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 592
Query: 973 IKFFNERAEHHDAQEIL 989
+K NE + D ++IL
Sbjct: 593 LKHINELSMKIDVEDIL 609
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 543 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 601
W+K + ++ ++Q ++ GG+ H +RK W FLLG++ + +K+E Q+
Sbjct: 327 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 386
Query: 602 RYQQVLAEWKA 612
Y ++ +WK+
Sbjct: 387 EYFRMKLQWKS 397
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 129 bits (323), Expect = 2e-29
Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)
Query: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
I+KDV R DR ++ P L L D++ +Y D+GYVQGM DLL+PLL ++N+
Sbjct: 433 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492
Query: 854 QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912
A+ CF+ M +M QNF M T + +L+++LDS + ++ D + YFC+
Sbjct: 493 VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551
Query: 913 RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972
RW L+ FKRE + D+ +WEV+W + +F L + A++E+ ++ I + + F +I
Sbjct: 552 RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 609
Query: 973 IKFFNERAEHHDAQEIL 989
+K NE + D ++IL
Sbjct: 610 LKHINELSMKIDVEDIL 626
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 543 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 601
W+K + ++ ++Q ++ GG+ H +RK W FLLG++ + +K+E Q+
Sbjct: 344 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 403
Query: 602 RYQQVLAEWKA 612
Y ++ +WK+
Sbjct: 404 EYFRMKLQWKS 414
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 115 bits (289), Expect = 2e-25
Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%)
Query: 659 SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 707
+ DL PP +PE + P+P E GP V ++ P+ L
Sbjct: 245 AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298
Query: 708 -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 763
P +N + G+ SL +G+ +G EE AH ++ + + K
Sbjct: 299 VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352
Query: 764 QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 820
Q + +E Y I++DV R DR N +Y P P L L
Sbjct: 353 QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401
Query: 821 DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 879
D++ +Y H D+GYVQGM DLL+P+L + N+ A+ CF M+ + NF M
Sbjct: 402 DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461
Query: 880 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 939
+ L+++LD L + + + D FC+RW L+ FKRE + DV +WEV+W
Sbjct: 462 QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519
Query: 940 HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995
+ + L +A A+++ R+ + + +I+K NE +++L A L
Sbjct: 520 -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574
Score = 37.4 bits (85), Expect = 0.071
Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%)
Query: 538 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 596
+T++ W+++ + +++ EL +++ GG+ +R++ W FLLG+ + + +E +
Sbjct: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340
Query: 597 AVVAARYQQVLAEWKACEVVVRQREREAH 625
Y ++ +WK+ +R H
Sbjct: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 114 bits (285), Expect = 5e-25
Identities = 66/211 (31%), Positives = 113/211 (53%), Gaps = 7/211 (3%)
Query: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
+DKDV R DRN +F PN+E +R ++ +Y + VGY QGM DL+AP+L + ++
Sbjct: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
Query: 854 QLAYSCFSHLMKR-MSQNFPNGGAMDTHFANMRSLIQILDSELFE-LMHQNGDYTHFYFC 911
+ CF LM+ + + P M+ +R L+++ ++ L+ D FC
Sbjct: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFC 607
Query: 912 YRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTD 971
+RW LL FKRE + +WE WA H +++F LFI +A+V Y + + + +
Sbjct: 608 HRWLLLCFKREFPEAEALRIWEACWA--HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQ 665
Query: 972 IIKFFNERAEHHDAQEILRIARDLVHKVQML 1002
++ F A H + + +LR AR L+++ ++L
Sbjct: 666 MLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
Score = 41.2 bits (95), Expect = 0.005
Identities = 17/53 (32%), Positives = 31/53 (58%)
Query: 554 KELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 606
+E +L + +++GGI+ IR +VWPFLL +Y + +E E + Y ++
Sbjct: 413 EEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEI 465
Score = 33.5 bits (75), Expect = 1.0
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 9/48 (18%)
Query: 258 LLYGKNHVLVQPKEDMEAV----PGYLSLHQSAE-----SLTLKWTPN 296
++Y KN+V V P E ++ + PGYL L+ + +L L W PN
Sbjct: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 110 bits (276), Expect = 5e-24
Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%)
Query: 799 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 854
KDV R DR + Y+ P +L L D++ +Y H V Y QGM DL +P+L +D++
Sbjct: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
Query: 855 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 913
A+ CF +MKR++ NF P+G AM T FA+++ L++ D + ++ + + G +FCYR
Sbjct: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
Query: 914 WFLLDFKRELLYEDVFAVWEVIWAA 938
W LL+ KRE ++D + EV W++
Sbjct: 409 WLLLELKREFAFDDALRMLEVTWSS 433
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/54 (35%), Positives = 32/54 (59%)
Query: 557 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 610
EL ++Y+GG+E +RK VW +LL Y G++ +E + Y+Q+ +EW
Sbjct: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272
Score = 35.0 bits (79), Expect = 0.35
Identities = 16/50 (32%), Positives = 28/50 (56%)
Query: 946 FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995
F+LF+ LA++ +R+ I N +D+ ++ F+ H +LR AR L
Sbjct: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 60.1 bits (144), Expect = 1e-08
Identities = 49/199 (24%), Positives = 88/199 (44%), Gaps = 12/199 (6%)
Query: 788 DTVALNLHRIDKDVQRCDR-NYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPL 846
DT +I+ D+ RC + + +P + R V+ ++V H D+ Y QG+ L AP
Sbjct: 433 DTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPF 492
Query: 847 L-VTLDNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQN 902
L + +N+ LAY+C S + + NF N + + +I D EL +++
Sbjct: 493 LYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEI 552
Query: 903 GDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREII 962
G Y WFL F +F +W+ + + + F I +A+++ R+ +
Sbjct: 553 GFIPDLY-AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRL 607
Query: 963 RDNNMDFTDIIKFFNERAE 981
N F + I F++ E
Sbjct: 608 LANG--FNECILLFSDLPE 624
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)
Query: 793 NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 850
+L I D+ R N F P + L ++ +Y DVGYVQGM + A L++ L
Sbjct: 182 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 241
Query: 851 DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 907
D A+ FS+L+ + Q + G M T+FA + +LF +N + T
Sbjct: 242 DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 299
Query: 908 FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 967
+ W + + L + +W+V E F+ AL +++ + +I+ M
Sbjct: 300 DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 353
Query: 968 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
DF + +F E A+E+ + +QM NK
Sbjct: 354 DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 388
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)
Query: 793 NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 850
+L I D+ R N F P + L ++ +Y DVGYVQGM + A L++ L
Sbjct: 462 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 521
Query: 851 DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 907
D A+ FS+L+ + Q + G M T+FA + +LF +N + T
Sbjct: 522 DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 579
Query: 908 FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 967
+ W + + L + +W+V E F+ AL +++ + +I+ M
Sbjct: 580 DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 633
Query: 968 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
DF + +F E A+E+ + +QM NK
Sbjct: 634 DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 668
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)
Query: 793 NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 850
+L I D+ R N F P + L ++ +Y DVGYVQGM + A L++ L
Sbjct: 462 SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 521
Query: 851 DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 907
D A+ FS+L+ + Q + G M T+FA + +LF +N + T
Sbjct: 522 DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 579
Query: 908 FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 967
+ W + + L + +W+V E F+ AL +++ + +I+ M
Sbjct: 580 DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 633
Query: 968 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006
DF + +F E A+E+ + +QM NK
Sbjct: 634 DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 668
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 50.8 bits (120), Expect = 6e-06
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 5/143 (3%)
Query: 796 RIDKDVQRCDRNYWYFTPPNL---ERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDN 852
+I+ D+ R N +FT P ++LR V+ ++ W++ +GY QG+ L A L+ L+
Sbjct: 669 QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728
Query: 853 DQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDY--THFYF 910
++ A+ C +++ + + + R L +L +L LM G +
Sbjct: 729 EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788
Query: 911 CYRWFLLDFKRELLYEDVFAVWE 933
+ WFL+ F L+ + VW+
Sbjct: 789 TFNWFLVVFADSLISNILLRVWD 811
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/178 (24%), Positives = 81/178 (45%), Gaps = 21/178 (11%)
Query: 833 VGYVQGMCDLLAPLLVTLDNDQLA----------YSCFSHLMKRMSQNF-----PNGGAM 877
+ YVQGM +++ PL T D + + CF++LM + NF + +
Sbjct: 225 IAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGI 284
Query: 878 DTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWA 937
+ S ++ D EL+ L Q + +F +RW L +E L DV +W+ ++A
Sbjct: 285 TYKMEKVYSTLKDKDVELY-LKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFA 343
Query: 938 ARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995
+ F+L + A++ RE + + DFT ++ + D +IL+ A++L
Sbjct: 344 --DDNRFDFLLLVCCAMLMLIREQLLEG--DFTVNMRLLQD-YPITDVCQILQKAKEL 396
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 45.8 bits (107), Expect = 2e-04
Identities = 47/201 (23%), Positives = 86/201 (42%), Gaps = 13/201 (6%)
Query: 793 NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 850
+L I D+ R + + F P + L ++ +Y DVGYVQGM + A L++ L
Sbjct: 543 SLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 602
Query: 851 DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 907
+ A+ F++L+ + Q + M +FA + S+LF L ++ T
Sbjct: 603 EEAD-AFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLF-LHFKSYSLTP 660
Query: 908 FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 967
+ W + + L + VW+V E F+ L ++ Y +I+ M
Sbjct: 661 DIYLIDWIFTLYSKSLPLDLACRVWDVFCR----DGEEFLFRTGLGILRLYEDILL--QM 714
Query: 968 DFTDIIKFFNERAEHHDAQEI 988
DF I +F + E ++++
Sbjct: 715 DFIHIAQFLTKLPEDITSEKL 735
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/131 (20%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Query: 805 DRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLM 864
+++Y T +++LR+V+ ++ W + D+GY QG+ L+A L+ L+ + + + +
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
Query: 865 KRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--FCYRWFLLDFKRE 922
M +++ + + + R ++ +L L Y Y + WFL+ F
Sbjct: 781 VFMPRDYYTKTLLGSQ-VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDS 839
Query: 923 LLYEDVFAVWE 933
++ + +F +W+
Sbjct: 840 VVSDILFKIWD 850
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/131 (20%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Query: 805 DRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLM 864
+++Y T +++LR+V+ ++ W + D+GY QG+ L+A L+ L+ + + + +
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
Query: 865 KRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--FCYRWFLLDFKRE 922
M +++ + + + R ++ +L L Y Y + WFL+ F
Sbjct: 781 VFMPRDYYTKTLLGSQ-VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDS 839
Query: 923 LLYEDVFAVWE 933
++ + +F +W+
Sbjct: 840 VVSDILFKIWD 850
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/219 (19%), Positives = 81/219 (36%), Gaps = 29/219 (13%)
Query: 796 RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855
+I D+ R P E ++ + H GYVQG+ DL+ P V + +
Sbjct: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338
Query: 856 ------------------------AYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQI 890
Y C S L+ + N+ + + L+
Sbjct: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398
Query: 891 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFI 950
+D ++ + Q+ + + F +RW RE+ +W+ + + HF L++
Sbjct: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456
Query: 951 ALALVEAYREIIRDNNMDFTDIIKFF-NERAEHHDAQEI 988
A + +R+ I + DF +++ F N H D ++I
Sbjct: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDI 494
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 39.3 bits (90), Expect = 0.019
Identities = 44/213 (20%), Positives = 91/213 (42%), Gaps = 13/213 (6%)
Query: 785 ELLDTVALNLHRIDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCD 841
ELL + H I D+ R + YF+ P L +++ +Y +VGY QG+
Sbjct: 954 ELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISF 1013
Query: 842 LLAPLLVTLDNDQLAYSCFSHLMKRM---SQNFPNGGAMDTHFANMRSLIQILDSELFEL 898
+ LL+ + +Q A+ LM + Q P+ ++ + L+ +L+
Sbjct: 1014 VAGVLLLHMSEEQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNH 1072
Query: 899 MHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAY 958
+ +N + + + WFL F + V V+++I+ + + +AL+L+ +
Sbjct: 1073 LEEN-EISPSLYAAPWFLTLFASQFSLGFVARVFDIIF----LQGTEVIFKVALSLLSSQ 1127
Query: 959 REIIRDNNMDFTDIIKFFNERAEHHDAQEILRI 991
+I + F +I++F + E+ +I
Sbjct: 1128 ETLIMECE-SFENIVEFLKNTLPDMNTSEMEKI 1159
>gi|116292170 RUN domain containing 2A [Homo sapiens]
Length = 375
Score = 38.9 bits (89), Expect = 0.025
Identities = 51/182 (28%), Positives = 79/182 (43%), Gaps = 23/182 (12%)
Query: 2 GSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDS-SHIIALCGAVEACLLHQLRRRAA 60
GS + ++ LL + VKQ RK + DS S + LC EA L H L+R
Sbjct: 3 GSQNNDKRQFLLERLLDAVKQCQIRFGGRKEIASDSDSRVTCLCAQFEAVLQHGLKRSRG 62
Query: 61 GFLRSD--KMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGK 118
L + K AA F +T PV + V+E+ + E ++ +LR S G+
Sbjct: 63 LALTAAAIKQAAGFASKTETEPV---FWYYVKEVLNKHELQR-----FYSLRHIASDVGR 114
Query: 119 APALSPQALKHVWVRTALIEKVLDKVV-QYLAENC--SKYYEKEALLADPVFGPILASLL 175
A W+R AL E L++ + LA+ C S +YE + + D +L ++
Sbjct: 115 GRA---------WLRCALNEHSLERYLHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMA 165
Query: 176 VG 177
G
Sbjct: 166 AG 167
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 38.5 bits (88), Expect = 0.032
Identities = 36/154 (23%), Positives = 71/154 (46%), Gaps = 8/154 (5%)
Query: 812 TPPNLER-LRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 870
T P L+R L +V+ +Y + VGY QGM + L++ +N++ ++ L+ R+ +
Sbjct: 129 TDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPD 188
Query: 871 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDV 928
+ P + T + L++ + LM + G RWF+ F L E V
Sbjct: 189 YYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-VLWTLLVSRWFICLFVDILPVETV 247
Query: 929 FAVWEVIWAARHISSEHFVLFIALALVEAYREII 962
+W+ ++ + +AL L++ ++E+I
Sbjct: 248 LRIWDCLFN----EGSKIIFRVALTLIKQHQELI 277
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 37.7 bits (86), Expect = 0.055
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 14/193 (7%)
Query: 793 NLHRIDKDVQRCDRNYWYFTPP---NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVT 849
++ +ID DV R R++ F + L V+ +Y + +VGY QGM + A LL+
Sbjct: 140 DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMY 199
Query: 850 LDNDQLAYS---CFSHLMKRMSQNFPNGGAMDTHF-ANMRSLIQILDSELFELMHQNGDY 905
++ + ++ FS M F G F + ++ S+L + + Y
Sbjct: 200 MNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIY 259
Query: 906 THFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDN 965
T FY +WF F L F + IW E + ++ +++ +++ +
Sbjct: 260 TSFY-TMKWFFQCF----LDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL 314
Query: 966 NMDFTDIIKFFNE 978
+M+ ++++FF E
Sbjct: 315 SME--ELVEFFQE 325
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 37.7 bits (86), Expect = 0.055
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 14/193 (7%)
Query: 793 NLHRIDKDVQRCDRNYWYFTPP---NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVT 849
++ +ID DV R R++ F + L V+ +Y + +VGY QGM + A LL+
Sbjct: 157 DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMY 216
Query: 850 LDNDQLAYS---CFSHLMKRMSQNFPNGGAMDTHF-ANMRSLIQILDSELFELMHQNGDY 905
++ + ++ FS M F G F + ++ S+L + + Y
Sbjct: 217 MNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIY 276
Query: 906 THFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDN 965
T FY +WF F L F + IW E + ++ +++ +++ +
Sbjct: 277 TSFY-TMKWFFQCF----LDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL 331
Query: 966 NMDFTDIIKFFNE 978
+M+ ++++FF E
Sbjct: 332 SME--ELVEFFQE 342
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 37.7 bits (86), Expect = 0.055
Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)
Query: 9 KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
+ L+ +K +K +++ A++ + + D + + +E CL H L+ + + ++
Sbjct: 5 RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 64
Query: 68 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
V K CP A +I V+ L + +A G+ A
Sbjct: 65 FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 101
Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
W+ AL++K L ++ L +N S++YE EAL+ + G ++ LLVG
Sbjct: 102 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 150
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 37.7 bits (86), Expect = 0.055
Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)
Query: 9 KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
+ L+ +K +K +++ A++ + + D + + +E CL H L+ + + ++
Sbjct: 5 RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 64
Query: 68 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
V K CP A +I V+ L + +A G+ A
Sbjct: 65 FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 101
Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
W+ AL++K L ++ L +N S++YE EAL+ + G ++ LLVG
Sbjct: 102 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 150
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 37.7 bits (86), Expect = 0.055
Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)
Query: 9 KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
+ L+ +K +K +++ A++ + + D + + +E CL H L+ + + ++
Sbjct: 113 RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 172
Query: 68 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
V K CP A +I V+ L + +A G+ A
Sbjct: 173 FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 209
Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
W+ AL++K L ++ L +N S++YE EAL+ + G ++ LLVG
Sbjct: 210 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 258
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,675,021
Number of Sequences: 37866
Number of extensions: 2214737
Number of successful extensions: 9713
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 9341
Number of HSP's gapped (non-prelim): 457
length of query: 1006
length of database: 18,247,518
effective HSP length: 112
effective length of query: 894
effective length of database: 14,006,526
effective search space: 12521834244
effective search space used: 12521834244
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.