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Search of human proteins with 148612801
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612801 KIAA1009 protein [Homo sapiens]
(1403 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612801 KIAA1009 protein [Homo sapiens] 2724 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 133 1e-30
gi|71061468 centromere protein E [Homo sapiens] 128 4e-29
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 126 1e-28
gi|55770834 centromere protein F [Homo sapiens] 124 5e-28
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 120 9e-27
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 120 1e-26
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 119 2e-26
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 119 3e-26
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 119 3e-26
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 119 3e-26
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 119 3e-26
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 119 3e-26
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 119 3e-26
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 119 3e-26
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 119 3e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 118 5e-26
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 117 6e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 117 6e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 117 8e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 117 8e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 114 5e-25
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 114 5e-25
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 113 1e-24
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 112 2e-24
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 112 3e-24
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 111 6e-24
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 110 7e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 110 7e-24
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 110 1e-23
>gi|148612801 KIAA1009 protein [Homo sapiens]
Length = 1403
Score = 2724 bits (7060), Expect = 0.0
Identities = 1403/1403 (100%), Positives = 1403/1403 (100%)
Query: 1 MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLL 60
MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLL
Sbjct: 1 MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLL 60
Query: 61 GTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGV 120
GTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGV
Sbjct: 61 GTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGV 120
Query: 121 GLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEH 180
GLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEH
Sbjct: 121 GLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEH 180
Query: 181 ENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANV 240
ENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANV
Sbjct: 181 ENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANV 240
Query: 241 VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIA 300
VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIA
Sbjct: 241 VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIA 300
Query: 301 HSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFG 360
HSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFG
Sbjct: 301 HSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFG 360
Query: 361 ISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTN 420
ISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTN
Sbjct: 361 ISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTN 420
Query: 421 ESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGA 480
ESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGA
Sbjct: 421 ESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGA 480
Query: 481 VMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK 540
VMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK
Sbjct: 481 VMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK 540
Query: 541 NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD 600
NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD
Sbjct: 541 NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD 600
Query: 601 SLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK 660
SLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK
Sbjct: 601 SLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK 660
Query: 661 ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY 720
ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY
Sbjct: 661 ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY 720
Query: 721 QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR
Sbjct: 721 QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
Query: 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK 840
NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK
Sbjct: 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK 840
Query: 841 LYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES 900
LYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES
Sbjct: 841 LYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES 900
Query: 901 GNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN 960
GNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN
Sbjct: 901 GNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN 960
Query: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD
Sbjct: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
Query: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ
Sbjct: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
Query: 1081 AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVL 1140
AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVL
Sbjct: 1081 AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVL 1140
Query: 1141 HSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAV 1200
HSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAV
Sbjct: 1141 HSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAV 1200
Query: 1201 MNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLI 1260
MNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLI
Sbjct: 1201 MNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLI 1260
Query: 1261 RHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK 1320
RHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK
Sbjct: 1261 RHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK 1320
Query: 1321 QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVL 1380
QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVL
Sbjct: 1321 QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVL 1380
Query: 1381 RELHRQGVVVPVAFADEMNAPEY 1403
RELHRQGVVVPVAFADEMNAPEY
Sbjct: 1381 RELHRQGVVVPVAFADEMNAPEY 1403
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 133 bits (334), Expect = 1e-30
Identities = 302/1483 (20%), Positives = 616/1483 (41%), Gaps = 195/1483 (13%)
Query: 6 QEELDEEFEQFMKELSDDSF---ENSDKTARQSKKE---MKKKDTVPWWITEDDFK---- 55
Q +LDE + K+ D S+ + S+K A +K + ++++D + T+ + +
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEH 1450
Query: 56 DDGLLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLST-DSLETNELVVSELN 114
D+ + V + K+ + EI EES K Q + +L+S ++L+ N+ + EL
Sbjct: 1451 DERIKQLQVELCEMKQKPE---EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL- 1506
Query: 115 HSSLGVGLDTLEEQEEKEQFFARLEKGLTS-SIDYSRLNKELDSNDSTHFKALHSNQANA 173
SL G T+E RL K L S NKE D+ AL + +
Sbjct: 1507 --SLARG--TIE----------RLTKSLADVESQVSAQNKEKDTVLGR--LALLQEERDK 1550
Query: 174 ELTDDEHENESKHEELAENYSDDFEDEYVGAPLT--TKDEEMPSKE--NSKSEKI--SVP 227
+T+ + L EN S E + L T+D+E KE + KS KI S
Sbjct: 1551 LITEMDRS-------LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
Query: 228 KQEEEKTGMLANVVLLDSLDSVA----------EVNLDEQDKITPKPRCLPEMTENEMTG 277
QE+ K +LL S ++V+ E E+ ++ K R TE
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS----TEANKKE 1659
Query: 278 TGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNI 337
T ++ ++E + + A S +QKI E+ + + HP + + +
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKS----KQQKILELEEENDRLRAEVHPA-GDTAKECM 1714
Query: 338 STMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQ 397
T+ S +++E ++ ++++ +S Q + SEK + +E + L ++ N+ Q
Sbjct: 1715 ETLLSSNASMKEELERVKMEYETLSK-KFQSLMSEKDSLSEEVQ---DLKHQIEGNVSKQ 1770
Query: 398 DSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSS 457
+ +K+D + + +S+ + ++ + + + S
Sbjct: 1771 ANLEAT---EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 458 SLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGK 517
S D+IN Y Q+ +E + G + +K + L+ + +
Sbjct: 1828 DFSSHDEINN-YLQQIDQLKE-RIAGLEEEKQKNKEFSQTLENEKNT------------- 1872
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
+ S + K E + + + ++ NQ ++E+ TKL + A +K E
Sbjct: 1873 ------LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD--DLEE 1924
Query: 578 CLSTRKKSENPTETDSC------------IQFQTDSLGYC-GENKEKKLLMFKRVQEAED 624
L + N + + C ++ + +L C E +E+K + K + E
Sbjct: 1925 RLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES 1984
Query: 625 KWRGAQALIEQIKATFSEK-EKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETN 683
+ R + +E+I+ E K +L+EL K++++E+ +L +D Q K+S+ E T
Sbjct: 1985 EIR--KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2042
Query: 684 KKQRWLHFGEAAD-PVTGEKL-------KQIQKEIQEQETLLQGYQQENERLYNQVKDLQ 735
K ++ D +T E L K+ Q E+ + LL Q E R+ L+
Sbjct: 2043 KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
Query: 736 EQNKKNEERMFKENQSLFSEVASLKEQM-HKSRFLSQVVEDSEPTRNQNFTDLLAELRMA 794
++ + N+E S+K QM K L + +E +E + ++ +L
Sbjct: 2103 KELQSNKE--------------SVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL 2148
Query: 795 QKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK----------LYEI 844
++EK L E I ++ + + +++++ D Q+A T + E
Sbjct: 2149 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEA 2208
Query: 845 KILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESG--N 902
K E I ++ ++ +N +L KD +LR+ + +E+LK+ I +L+ +
Sbjct: 2209 KKWERKFSDAIQSKEEEIRLKEDNCSVL-KD--QLRQMSIHMEELKINISRLEHDKQIWE 2265
Query: 903 PSIRQKIRLKDKAADAKKIQDLE--RQVKEMEGILKRRYPNSLPALILAASAAGDTVD-- 958
+ +++L+ K D + ++ E Q++E L N L L + D +
Sbjct: 2266 SKAQTEVQLQQKVCDTLQGENKELLSQLEETRH-LYHSSQNELAKLESELKSLKDQLTDL 2324
Query: 959 KNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYE--QRLEQQEQLLACKL 1016
N++E +++ LE + ++ D + S + EQ ++ E RL ++ + K+
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 1017 NQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIE- 1075
S + +A++ + ++++ H ++ LE + + +N L+ + D+ Q +E
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMET 2444
Query: 1076 ---FQVEQAHAKAKLVRLNEELAA----KKREIQDLSKTVER-----LQKDRRMM-LSNQ 1122
+ E KA+L + +++ + R + D + ER L+KD+ + + +
Sbjct: 2445 LKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAE 2504
Query: 1123 NSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVL----QENYR 1178
N+K +EE+ R+ D L+S ++ L Q T DS ++L Q+N
Sbjct: 2505 NNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564
Query: 1179 LKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNA 1238
L+N+ L + E + +E + F N+++ K+D + I SLK S I +L Q
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSF-NALQEEKQDLSKEIESLKVS----ISQLTRQVT 2619
Query: 1239 VENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEIL--QKEITKLLE 1296
+ + ++ +E + + + Q + ++E+ EE++ QKE K +
Sbjct: 2620 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKR-----IAELEEELVCVQKEAAKKVG 2674
Query: 1297 ELREAKENHTPEMKHFVGL--------EKKIKQMEMRHAQREQELQQIIQQTHQVVETEQ 1348
E+ + + + H G+ E+++ ++ + EQ+L + ++ + Q
Sbjct: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734
Query: 1349 N--KEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQGVV 1389
+ + + + N EL++ + + D+ L L +L QG++
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Score = 124 bits (310), Expect = 8e-28
Identities = 261/1347 (19%), Positives = 554/1347 (41%), Gaps = 154/1347 (11%)
Query: 125 LEEQEEKEQFFARL--EKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHEN 182
+EE +EK + FA+ +K L + RL E+ T + + + ++ N
Sbjct: 1671 MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS---------N 1721
Query: 183 ESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVL 242
S EEL E ++E L+ K + + S+++S SE++ K + E NV
Sbjct: 1722 ASMKEEL-ERVKMEYET------LSKKFQSLMSEKDSLSEEVQDLKHQIE-----GNVSK 1769
Query: 243 LDSLDSVAEVNLDEQDKITPK-PRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAH 301
+L++ + D Q +T + + +P TE + + + + S V + A ++
Sbjct: 1770 QANLEATEKH--DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 302 SLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGI 361
D+ ++ +K + G +E ++N + T+E++ T+
Sbjct: 1828 DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL-------------- 1873
Query: 362 SGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTT-- 419
L +S++ + E + + L +N I + S+ L +E L++
Sbjct: 1874 ----LSQISTKDGELKMLQEEVTKMNL-LNQQIQEELSRVTKLKETAEEEKDDLEERLMN 1928
Query: 420 -----NESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLS 474
N S+ N C VT+ E ++ N L+K ++ Q K S++
Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKN-LKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 475 SEEEGAVMGKQV-PYKK--ARSAPPLLKRKPQSGLYASVRSSGYGKPSSPL----KMFST 527
E + G Q P K A+ LLK K Q Y + S L K
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Query: 528 LEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSEN 587
++ ++ +D+ +K + + ++ + + L+ K++ + A L +K+ ++
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107
Query: 588 PTET--DSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQ----IKATFS 641
E+ Q D + +EK L K +QE D R + +E+ I+ T +
Sbjct: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
Query: 642 EKEKELENKLEELKKQQE------KELFKLNQDNYILQAKLSSFEET-----NKKQRWLH 690
+K+KE++ E L K + L D + + +E K+ +
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 691 FGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQ 750
E V ++L+Q+ ++E + + + + + ++ + + +K + + EN+
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 751 SLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSL-------LE 803
L S++ + H S+ +E + TDL L +++K +L
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 804 DIKRLKQDKQALEVDFEKMKK------ERDQAKDQ--IAYVTG-EKLYEIKI--LEETHK 852
DI+ K + LE D + ++ E K+Q I+ ++G E+ ++ I L + H
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 853 QEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLK 912
+EI L+ L E +L+++ ++A ++ +L ++ +K E +I+QK +L
Sbjct: 2408 KEIKELENLLSQEEEENIVLEEEN---KKAVDKTNQLMETLKTIKKE----NIQQKAQLD 2460
Query: 913 DKAADAKKIQ-DLERQVKEMEGILKRRYPNSL--PALILAASAAGDTVD------KNTVE 963
+Q D +R V + + + +R L LI A+A + + ++ ++
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
Query: 964 FMEKRIKKLEADLEGKDEDAKKSLR---TMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
+ KL+A+L ED + + + ++Q ++++Q + LE + L KL + +
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 1021 SPR------IKALEKELDDIK---EAHQITVRNLEAEIDVLKHQ------NAELDVKKND 1065
AL++E D+ E+ ++++ L ++ L+ + +A+L VK+ +
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQD-LSKTVERLQKDRRMMLSNQNS 1124
Q A + +LV + +E A K EI+D L K ++ L D +M +
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM--RNET 2698
Query: 1125 KGREEMSAKRAK------KDVLHSSKGN------ANSFPGTLDSKLYQPHTFTDSHVSEV 1172
+ EE A+ A+ + +L +K N SF G S L + + E
Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSF-GRSMSSLQNSRDHANEELDE- 2756
Query: 1173 LQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEK 1232
L+ Y + + E+ L + +A++++ SM +E++ +H+ L + E+
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 1233 LL-CQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEI 1291
LL + +E+S ++V ++ +A+ + H +++ + + +E S + E+
Sbjct: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEV 2876
Query: 1292 TKLLEELREAKENHTPEMKHFVGLEKKIKQM-----EMRHAQREQELQQIIQQTHQVVET 1346
L + + + + +K L+++ Q+ E+ + + + Q + Q+++
Sbjct: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE 2936
Query: 1347 EQNKEVEKWKRLAQLKNRELEKFRTEL 1373
E +E W+ +L +EK E+
Sbjct: 2937 ELRQENLSWQH--ELHQLRMEKSSWEI 2961
Score = 122 bits (305), Expect = 3e-27
Identities = 314/1568 (20%), Positives = 625/1568 (39%), Gaps = 269/1568 (17%)
Query: 38 EMKKKDTVPWWITEDDFKDDGLLGTNVSYLKTKKTSQPVMEIEE--ESAEKIQFLKSSGT 95
E K KD V + +++ D L + S L SQ + E E AE+++ + S
Sbjct: 804 EAKSKD-VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
Query: 96 SLLSTDSLETNELVVSELNHSSLGVGLD--TLEEQ-EEKEQFFARLEKGLTSSIDYSRLN 152
L + +L EL +++++ L D TL++ EEK+Q + I +S
Sbjct: 863 EL--SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ--------QVTEISFSMTE 912
Query: 153 KELDSNDSTHFKALHSNQANAELTDDEHENESKHEELAENYSDDFEDEYVGAPLTTKDEE 212
K + N+ + +L E+K E++ E D V + L +E
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEE-------DNEVSSGLKQNYDE 965
Query: 213 M-PSKENSKSE---KISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLP 268
M P+ + SK E + + K+E E+ L++ + + V+ E++ K
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 269 EMTENEMTGTGVSYGQSSSD------VEALHQAYCHIAHSLGDED------KQKIESNTV 316
E+ +E V + + + + ++ ++ +++ ++ +E
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 317 --EDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKV 374
E ++ VK Q ++ + I +++++ + +++ + + S D V
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD-------SV 1138
Query: 375 AERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVT 434
A KET S P + + + L +K E LQK E++ + + +
Sbjct: 1139 ALVKETVVISP-PCTGSSEHWKPELEEKILALEKEKEQ--LQKKLQEALTSRKAILKKAQ 1195
Query: 435 ATEEHV------DKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPY 488
E H+ K N L+++ S +++ I R QL + ++ GK
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSK---ENENIGDQLR-QLQIQVRESIDGKLPST 1251
Query: 489 KKARSAP-------PLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK- 540
+ S PL K Q + S+ S + S L+ TS IK++
Sbjct: 1252 DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
Query: 541 ----------NLRSISTSNQPRKK--EILSGTKLIKPAALDKPAHKTES------CLSTR 582
L+ ST+++ KK E+ + I L+ + KT S S +
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQ 1371
Query: 583 KKSENPT-----------------ETDSCIQFQTDSLGYC-GENKEKKLLMFK---RVQE 621
+K E+ E I + + + Y G+ EK+ + K + E
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431
Query: 622 AEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK---ELFKLNQDNYILQAKLSS 678
ED + +E E+ K+L+ +L E+K++ E+ E Q LQA L S
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491
Query: 679 FEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQN 738
+E K+ + L E G ++++ K + + E+ + +E + + ++ LQE+
Sbjct: 1492 RKEALKENKSLQ--EELSLARGT-IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEER 1548
Query: 739 KK---NEERMFKENQSLFSEVASLKEQMH-----KSRFLSQVVEDSEPTRNQNFTDLLAE 790
K +R ENQSL S SLK + K + + ++ E + ++ T+ +
Sbjct: 1549 DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI-ESLKSSKIAESTEWQEK 1607
Query: 791 LRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEET 850
+ QKE + LL+ + + + + ++ E +++E+ + ++ K K L+E
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
Query: 851 HKQEISRLQKRLQWYAENQEL----LDKDALRLRE--------ANEEIEKL-------KL 891
+QE+ ++++++ +A++++ L+++ RLR A E +E L K
Sbjct: 1668 -EQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
Query: 892 EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVK---------------------- 929
E+E++K E S + + + +K + ++++QDL+ Q++
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT 1786
Query: 930 -----------EMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFME-----KRIKKLE 973
E + L + + +A +A V K+ E ++I +L+
Sbjct: 1787 EEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK 1846
Query: 974 ADLEGKDEDAKKSL---RTMEQQFQKMKIQY-----EQRLEQQEQLLACKLNQHDSPRIK 1025
+ G +E+ +K+ +T+E + + Q E ++ Q+E LNQ +
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906
Query: 1026 AL-------EKELDDIKEA---------------------HQITVRNLEAEIDVLKHQNA 1057
+ E+E DD++E QI LE+E+ LK +
Sbjct: 1907 RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966
Query: 1058 ELD------VKKNDKDDEDF-----QSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSK 1106
EL+ VK+ K + + + I+ ++ K+ L E L K++E++ L K
Sbjct: 1967 ELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQK 2026
Query: 1107 TVERLQKD--------RRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN--SFPGTLDS 1156
R Q+ + + S+ E++ + + V H K A SF LD
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086
Query: 1157 KLYQPHTFTDSHVSEVLQENYRLKNELEG-LISEKNELKMKSEAVMNQFE---------- 1205
T S + VL +N +LK EL+ S K+++K K E + + E
Sbjct: 2087 --------TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK 2138
Query: 1206 -------NSMRRVK---EDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIAT 1255
+++RR K E+T I +E+++L Q ++++ +++A + +++
Sbjct: 2139 KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL--QENLDSTVTQLAAFTKSMSS 2196
Query: 1256 QEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGL 1315
+ + + + K + S+ E L+++ +L++ H E+K +
Sbjct: 2197 LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256
Query: 1316 EKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDS 1375
+ KQ+ AQ E +LQQ + T Q E ++E+ + L EL K +EL S
Sbjct: 2257 LEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKS 2316
Query: 1376 ILDVLREL 1383
+ D L +L
Sbjct: 2317 LKDQLTDL 2324
Score = 102 bits (253), Expect = 3e-21
Identities = 175/871 (20%), Positives = 357/871 (40%), Gaps = 116/871 (13%)
Query: 523 KMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTR 582
K+ TL+ + E + + + R + S+Q ++ S K +K D ++ E C +
Sbjct: 2277 KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL-SNSLEKCKEQK 2335
Query: 583 KKSEN---PTETD------SCIQFQTDSLGYCGE-----NKEKKLLMFKRVQEAEDKWRG 628
E E D S Q +TD L E ++E + K + K
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETD-LQASRELTSRLHEEINMKEQKIISLLSGKEEA 2394
Query: 629 AQALIEQIKATFSEKEKELENKLEE-------LKKQQEKELFKLNQ----------DNYI 671
Q I +++ ++ KELEN L + L+++ +K + K NQ +N
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
Query: 672 LQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKE----IQEQETLLQGYQQENERL 727
+A+L SF ++ + D + G+ +Q+++ I E++ L+Q EN +L
Sbjct: 2455 QKAQLDSFVKSMSSLQ-----NDRDRIVGD-YQQLEERHLSIILEKDQLIQEAAAENNKL 2508
Query: 728 YNQVK-------DLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR 780
+++ DL +N K + + + + L ++V ++K+ K Q+ ++ E
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDL-NQVITIKDSQQKQLLEVQLQQNKE--L 2565
Query: 781 NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK 840
+ L +L+ +++ + L L+++KQ L + E +K Q Q+ + E
Sbjct: 2566 ENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
Query: 841 ---LYEIKIL---EETHKQE--ISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLE 892
LY ++ EE H+ S QKR+ E + K+A + + E +KLK E
Sbjct: 2626 TLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK--KVGEIEDKLKKE 2683
Query: 893 IEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASA 952
++ L ++G I + +++ +L R + EME L L++
Sbjct: 2684 LKHLHHDAG-------IMRNETETAEERVAELARDLVEMEQKL----------LMVTKEN 2726
Query: 953 AGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLL 1012
G T ++ + + L+ + +E+ + R + +++ EQ L +E+
Sbjct: 2727 KGLTAQ---IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER-- 2781
Query: 1013 ACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQ 1072
L++ E L +++ +Q L ++ + L H +++L+ N
Sbjct: 2782 DALLSETAFSMNSTEENSLSHLEKLNQ----QLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837
Query: 1073 SIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSA 1132
Q E+ H +L + + K+R S + +Q ++ M S QN + R
Sbjct: 2838 MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKEL 2897
Query: 1133 KRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVL-QENYRLKNELEGLISEKN 1191
K ++ L ++ P + YQ T + E L QEN ++EL L EK+
Sbjct: 2898 KNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKS 2957
Query: 1192 ELKMKSEAVMNQFENSMRRVKEDTAAHIASL-----KASHQREIEKLLCQNAVENSSSKV 1246
++ + Q+ ++ K+ +H+ +L +S Q + K+ Q +S
Sbjct: 2958 SWEIHERRMKEQYLMAISD-KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Query: 1247 AELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEE--------- 1297
+ ++ + + L+R +L + + E+R + L ++LLEE
Sbjct: 3017 PDGSQNLVYETELLR------TQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLC 3070
Query: 1298 -----LREAKENHTPEMKHFVGLEKKIKQME 1323
LRE ++++ + H LEK++++++
Sbjct: 3071 DTSQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101
Score = 91.7 bits (226), Expect = 5e-18
Identities = 164/807 (20%), Positives = 348/807 (43%), Gaps = 96/807 (11%)
Query: 614 LMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELK---KQQEKELFKLNQDNY 670
L+ + + AE + + ++Q++A + +E + EE K ++ E E+ + +
Sbjct: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Query: 671 ILQAK----LSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK-EIQEQETLLQGYQQENE 725
LQ + L FE+ + Q L +A L+Q K E++E+ + + Q+ +
Sbjct: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSA-------LEQKHKAEMEEKTSHILSLQKTGQ 389
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHK-----SRFLSQVVEDSEPTR 780
L + L++QN K + ++ + L++Q+ + S+FL+++ T
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 781 NQ-NFTDLLAELRMAQKEKD--SLLEDIKRLKQDKQAL---EVDFEKMKKERDQAKDQIA 834
+Q +F D+ E A E++ SL + + L+ +K AL ++ E++K E ++ QI
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 835 YV-----TGE---KLYEIKILEETHKQEISRLQKRLQ----WYAENQELLDKDALRLREA 882
+ TGE ++ EI I++ +K+ S + +++ + L L ++EA
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
Query: 883 NEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQV----KEMEGILKRR 938
EEI LKL+++ +AE + + + +K + I ++ +V + L
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEG--IAPIKMKVFLEDTGQDFPLMPN 627
Query: 939 YPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMK 998
+SLPA+ A T E E + +L+ +D KSL + Q +
Sbjct: 628 EESSLPAV--EKEQASTEHQSRTSE--EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 999 IQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAE 1058
+ E+ + Q+L +LN H + I EK LD+ +A +I+ NL I+ K
Sbjct: 684 DELERL---KSQILELELNFHKAQEI--YEKNLDE--KAKEIS--NLNQLIEEFK----- 729
Query: 1059 LDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRM- 1117
K D + F ++ + +Q ++ K + + EL A +++ L + ++ RR+
Sbjct: 730 ---KNADNNSSAFTALSEERDQLLSQVKELSMVTELRA---QVKQLEMNLAEAERQRRLD 783
Query: 1118 ---------MLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSH 1168
+L+ Q E +K K +VL + + + + + +
Sbjct: 784 YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNK 843
Query: 1169 VSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQR 1228
SEVL+ R+++ + + E ++ + E + + + + K D +++ Q+
Sbjct: 844 ESEVLEGAERVRH-ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 1229 EIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQ 1288
E + + K+ +LN + + V I+ + Q+N L +E+ + +
Sbjct: 903 VTEISF------SMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS 956
Query: 1289 KEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQ-----REQELQQIIQQTHQV 1343
+ + +E+ A + E++H L KK + R Q R++ LQ++ + ++
Sbjct: 957 SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL 1016
Query: 1344 --VETEQNKEVEKWKRLAQLKNRELEK 1368
++ E KE+ L++ + E+E+
Sbjct: 1017 ANLKDESKKEIP----LSETERGEVEE 1039
Score = 89.7 bits (221), Expect = 2e-17
Identities = 283/1468 (19%), Positives = 574/1468 (39%), Gaps = 221/1468 (15%)
Query: 7 EELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNVSY 66
++ +E QF+ L E + +T S ++ + T +TE++ L V
Sbjct: 428 QQKSKEISQFLNRLPLQQHETASQT---SFPDVYNEGTQA--VTEENIAS---LQKRVVE 479
Query: 67 LKTKKTSQPVMEIE-EESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTL 125
L+ +K + + IE EE + + L S T L + + + VSE++ + +
Sbjct: 480 LENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
Query: 126 EE---QEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHEN 182
E Q+ E F++ K L+ + + +E + + + +A+ E+ D +
Sbjct: 540 AEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599
Query: 183 ESKHEELA--------ENYSDDFE---DEYVGAPLTTKDEEMPSKENSKSEKISV----- 226
+ + E +A E+ DF +E P K++ ++ SE+IS+
Sbjct: 600 QMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGV 659
Query: 227 ----PKQEEEKT----------------GMLANVVLLD----SLDSVAEVNLDEQDK-IT 261
KQ+ +K+ + + ++ L+ + E NLDE+ K I+
Sbjct: 660 ELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEIS 719
Query: 262 PKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAY-CHIAHSLGDEDKQKIESNTVEDIK 320
+ + E +N + S + L Q + L + KQ +E N E +
Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQ-LEMNLAEAER 778
Query: 321 SSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVA----- 375
+ E++ N+ T + ++E K ++I+ D+Q SE+
Sbjct: 779 QRRLDY--ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
Query: 376 ----ERKETEFFSSLP----LKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSC 427
+ KE+E + LSQ L K D+ ++ +K E+++ +
Sbjct: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT- 895
Query: 428 PQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVP 487
+ ++ V ++ ++ K + +N S +I KT + QL+ ++ +
Sbjct: 896 -----IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI-KTLKEQLN------LLSRAEE 943
Query: 488 YKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSIST 547
KK + + SGL Y + SP S E + D++K +N
Sbjct: 944 AKKEQVEED---NEVSSGL-----KQNYDE-MSPAGQISKEELQHEFDLLKKEN------ 988
Query: 548 SNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGE 607
+ RK+++ + LI L + + E L+ K E+ I G E
Sbjct: 989 --EQRKRKLQAA--LINRKELLQRVSRLEEELANLKD-----ESKKEIPLSETERGEVEE 1039
Query: 608 NKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELEN---KLEELKKQQEKELFK 664
+KE K K V Q + +K T SEKE EL++ LEE +E+
Sbjct: 1040 DKENKEYSEKCVTSK------CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
Query: 665 LNQDNYILQAKLSSFE----ETNKKQRWLH--FGEAADPVTGEKLKQIQKEIQEQETLLQ 718
+ Q N LQ K + + E ++ Q + D G+ + +++ +
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
Query: 719 GYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEP 778
+ L ++ L+ K+ E+ K ++L S A LK+ K R L + ++ +
Sbjct: 1154 SSEHWKPELEEKILALE---KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
Query: 779 TRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-QDKQALEVDFEKMKKERDQAKDQIAYVT 837
N+ L + KE +++ + +++L+ Q +++++ K ++ +
Sbjct: 1211 DYNR----LQEQFDEQSKENENIGDQLRQLQIQVRESID-----GKLPSTDQQESCSSTP 1261
Query: 838 GEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLK 897
G + K E+ H Q + W + ++ D AL + + ++K ++++++
Sbjct: 1262 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSE---DASAL---QGGTSVAQIKAQLKEIE 1315
Query: 898 AESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTV 957
AE ++ + ++++ L+ Q+ + ++ S A + A S
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL----- 1370
Query: 958 DKNTVEFMEKRIKKLE--ADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACK 1015
+ +E + +I LE +L+ K ++ +K + E+ + Q ++ ++
Sbjct: 1371 -QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI 1429
Query: 1016 LNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIE 1075
+ Q D IKAL +L+ + H ++ L+ E+ +K + E+ + K
Sbjct: 1430 IEQED--LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK--------- 1478
Query: 1076 FQVEQAHAKAKLVRLNEELAAKKREIQDLS---KTVERLQKDRRMMLSNQNSKGREEMSA 1132
Q Q +A L+ E L K ++LS T+ERL K L++ S ++SA
Sbjct: 1479 -QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS----LADVES----QVSA 1529
Query: 1133 KRAKKDV----LHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLIS 1188
+ +KD L + + +D L + + + S S LK LEGL
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES--------LKLALEGLTE 1581
Query: 1189 EKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASH---QREIEKLLCQNAVENSSSK 1245
+K +L + E+ +K A + H Q+E E LL + EN S++
Sbjct: 1582 DKEKLVKEIES-----------LKSSKIAESTEWQEKHKELQKEYEILL--QSYENVSNE 1628
Query: 1246 VAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENH 1305
+ ++ + + EL K S E +KE K L+E + E
Sbjct: 1629 AERIQH-------VVEAVRQEKQELYGKLRS-------TEANKKETEKQLQEAEQEMEEM 1674
Query: 1306 TPEMKHFV-GLEKKIKQMEMRHAQREQELQQIIQQTHQVVET------EQNKEVEKWKRL 1358
+M+ F ++KI ++E + + E+ + +ET +E+E+ K
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
Query: 1359 AQLKNRELEKFRTELDSILDVLRELHRQ 1386
+ +++ + +E DS+ + +++L Q
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Score = 80.9 bits (198), Expect = 8e-15
Identities = 155/806 (19%), Positives = 322/806 (39%), Gaps = 92/806 (11%)
Query: 619 VQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSS 678
V E +D R ++Q E+ K +NK+++LK + +L LN+ YI + K
Sbjct: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK--YIEEMKAQG 118
Query: 679 FEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQN 738
+P + E+L + K E+E ++ + + + + LQ Q
Sbjct: 119 GTVL-----------PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL 167
Query: 739 KKNEERMFKENQSLFSEVASLKEQM-HKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKE 797
+ + ++ + E +K+Q+ K F+S + T+ + + +E
Sbjct: 168 TQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ------AAQQVVRE 221
Query: 798 KDSLLEDIKRLKQD---KQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQE 854
KD+ E RL +D + + D E +++ + + E L + + +QE
Sbjct: 222 KDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE 281
Query: 855 ISRLQKRLQWYAENQELLDKDALRLREANE-EIEKLKLEIEKLKAESGNPSIRQKIRLKD 913
++ ++R Q ++ + ++ + LR E E E+ K+ +EK++ E +K+ +
Sbjct: 282 LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA----ERKLSFHN 337
Query: 914 KAADAKKIQDLERQVKEMEGILKRRYP----------NSLPALILAASAAGDTVDKNTVE 963
+ + + Q + + L+ RY + IL+ G + ++ +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL-QSACD 396
Query: 964 FMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLL-ACKLNQHDSP 1022
++ + KL L+ K+E A +S +T++Q ++ Q +Q+ ++ Q L L QH++
Sbjct: 397 ALKDQNSKL---LQDKNEQAVQSAQTIQQ----LEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 1023 RIKALEKELDDIKEA--------HQITVRNLEAEIDVLKHQNAELDVKK--NDKDDEDFQ 1072
+ ++ +A Q V LE E L + EL+ K N+K
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 1073 SIEFQVEQAHAKAKLVRL------NEELAAKKREIQD-LSKTVERLQKDRRMMLSNQNSK 1125
+E Q A ++ + N+ ++ + QD L T + K+ ++L
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
Query: 1126 GRE------EMSAKRAKK---DVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
E ++ KRA++ +VL + G K+ T + E
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKED---TAAHIASLKASHQREIEKL 1233
L + S +++ + E +N ++ K+D + + + + HQ E+E+L
Sbjct: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 1234 LCQNAVENSSSKVAELNRKI-ATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEIT 1292
S++ EL QE+ ++ + E+ + + + + + T
Sbjct: 690 ---------KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFT 740
Query: 1293 KLLEELREAKENHTPEMKHFVGLEKKIKQMEMR--HAQREQELQQIIQQTHQVVETEQNK 1350
L EE R+ + E+ L ++KQ+EM A+R++ L Q H + TEQ
Sbjct: 741 ALSEE-RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQ-- 797
Query: 1351 EVEKWKRLAQLKNRELEKFRTELDSI 1376
+ A+ K+ ++E + ELD +
Sbjct: 798 -IHSLSIEAKSKDVKIEVLQNELDDV 822
Score = 80.9 bits (198), Expect = 8e-15
Identities = 161/844 (19%), Positives = 346/844 (40%), Gaps = 106/844 (12%)
Query: 596 QFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKE--KELENKLEE 653
Q Q + E+ ++M +++QE E+ QA + Q +A + ++ +E + + E
Sbjct: 169 QAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFET 228
Query: 654 LKKQQEKELFKL----------NQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKL 703
+ E EL +L Q +LQ KL EE+ + + D + ++L
Sbjct: 229 QVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR-----AQVVD-LLQQEL 282
Query: 704 KQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQM 763
++ Q LQ + E+ L N V+ +E++K E+M E +L+E+M
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342
Query: 764 HKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMK 823
H + ++ ++ L + + +EK S + +++ Q+ Q+ +
Sbjct: 343 HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402
Query: 824 KERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQ---------------WYAEN 868
+ Q K++ A + + + +++ + +EIS+ RL +
Sbjct: 403 SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
Query: 869 QELLDKDALRLREANEEIEKLK-------LEIEKLKAESGNPSIRQKIRLKDKAADAKKI 921
Q + +++ L++ E+E K +E+E+LKAE N + +I L + +
Sbjct: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE--NEKLSSQITLLEA---QNRT 517
Query: 922 QDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADL-EGKD 980
+ +R+V E+ + +S +A +G V +NT K + L ++ E ++
Sbjct: 518 GEADREVSEISIVDIANKRSS------SAEESGQDVLENTFSQKHKELSVLLLEMKEAQE 571
Query: 981 EDAKKSL----RTMEQQFQKMKIQYEQRLEQQEQLLACKL------NQHDSPRIKALEKE 1030
E A L + E+ ++ Q E + + E + K+ D P + E
Sbjct: 572 EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Query: 1031 LDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAH------AK 1084
L + E Q + + + + +A +++K +D + S + Q H K
Sbjct: 632 LPAV-EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK 690
Query: 1085 AKLVRL-----------NEELAAKKREIQDLSKTVERLQK--DRRMMLSNQNSKGREEMS 1131
++++ L + L K +EI +L++ +E +K D S+ R+++
Sbjct: 691 SQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLL 750
Query: 1132 AKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKN 1191
++ + ++ + L Q + S+ +N L ++ L E
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQRRL---DYESQTAHDNL-LTEQIHSLSIEAK 806
Query: 1192 ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQ-REIEKLLCQNAVENSSSKVAELN 1250
+K E + N+ ++ + E + I SL++ Q +E E L V + SSKV EL+
Sbjct: 807 SKDVKIEVLQNELDDVQLQFSEQSTL-IRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVRE-EILQKEITKLLEELREAKENHTPEM 1309
+ ++ +E+ I +K + L++ + R+ E LQ+ I + +++ E + T +M
Sbjct: 866 QALSQKELEI-----------TKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 1310 ------KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKN 1363
K +G+E K + ++ R +E ++ + V + + ++ Q+
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 1364 RELE 1367
EL+
Sbjct: 975 EELQ 978
Score = 63.2 bits (152), Expect = 2e-09
Identities = 255/1315 (19%), Positives = 527/1315 (40%), Gaps = 154/1315 (11%)
Query: 5 SQEELDEEFEQFMKELSD--DSFEN--SDKTARQSKKEMKKKD--TVPWWITEDDFKDDG 58
++EE D+ E+ M +L++ S N D T Q K E+ + + + ++E + +
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 59 LLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSL 118
L+ KTK S EI +E EKIQ + + + + E EL+ E
Sbjct: 1975 LVKE-----KTKVES----EIRKEYLEKIQGAQKEPGN--KSHAKELQELL-KEKQQEVK 2022
Query: 119 GVGLDTLEEQEE---KEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAEL 175
+ D + QE+ E+ LE T S + KE + H K + A+ ++
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV 2082
Query: 176 TDDEHENESKHEELAENYSDDFE----DEYVGAPLTTKDEEMPSK-ENSKSEKISVPKQE 230
D+ ++E+ LA+N E E V + + KDE++ + E ++ + + K
Sbjct: 2083 LLDDTQSEAARV-LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNM 2141
Query: 231 EEKTGMLANV-VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDV 289
+EK L V L+ +V L+++DK + + + T ++ S D
Sbjct: 2142 QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 290 EALHQAYCHIAHSLGD-----EDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDL 344
+ + D E++ +++ + +K ++ EE NIS +E D
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
Query: 345 PTVE-ELMKPIRIDSFGISGFDLQPVSSEKVAERKETE--FFSSLP--LKMNPNILSQDS 399
E + +++ LQ + E +++ +ET + SS K+ + S
Sbjct: 2262 QIWESKAQTEVQLQQKVCD--TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319
Query: 400 QHVNLF--FDK------NDENVILQKTTN-ESMENSCPQV-TEVTATEEHVDKMYLNILR 449
Q +L +K N E +I Q+ + ++ + S Q+ T++ A+ E +++ I
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
Query: 450 KK-------------ITVNSSSLSQD-DKINKTYRSQLSSEEEGAVMGKQVPYK---KAR 492
K+ I V + L Q DK K + LS EEE ++ ++ K K
Sbjct: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
Query: 493 SAPPLLKRKPQSGLYASVRSSGYGKPSSPLKM--------FSTLEKKTSEDIIKSKNLRS 544
LK + + + + K S L+ + LE++ I++ L
Sbjct: 2440 QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499
Query: 545 ISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD--SL 602
+ + + KE + G + +H + SEN IQ++ D +
Sbjct: 2500 EAAAENNKLKEEIRGLR----------SHMDDL------NSENAKLDAELIQYREDLNQV 2543
Query: 603 GYCGENKEKKLL--MFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK 660
++++K+LL ++ +E E+K+ + +++ + + + N L+E K+ K
Sbjct: 2544 ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF-NALQEEKQDLSK 2602
Query: 661 ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQI-------QKEIQEQ 713
E+ L L ++++ +E L A V E++ ++ QK I E
Sbjct: 2603 EIESLKVSISQLTRQVTALQEEGT----LGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 714 ETLLQGYQQENERLYNQVKDLQEQNKKNEER----MFKENQSLFSEVASL-KEQMHKSRF 768
E L Q+E + +++D ++ K+ M E ++ VA L ++ + +
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 769 LSQVVEDSE--PTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEK----M 822
L V ++++ + Q+F ++ L+ ++ + L+++KR K D E+ K +
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR-KYDASLKELAQLKEQGLL 2777
Query: 823 KKERDQAKDQIAY-VTGEKLYEIKILEETHKQEISR------LQKRLQWYAENQELLDKD 875
+ERD + A+ + + + LE+ ++Q +S+ L +L+ + K
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837
Query: 876 ALRLREANE----EIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEM 931
L+ + E+EK + E + + PS K A + D +R +KE+
Sbjct: 2838 MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKEL 2897
Query: 932 EGILKR--RYPNSLPALILAASAAGDTVDKNTV-EFMEKRIKKLEADLEGKDEDAKKSLR 988
+ + ++ + + L + + DK + M++ +++ + + +
Sbjct: 2898 KNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKS 2957
Query: 989 TMEQQFQKMKIQYEQRLEQQEQLLACKLN---------QHDSPRIKALEKELDDIKEAHQ 1039
+ E ++MK QY + ++Q L+ N P +++ A
Sbjct: 2958 SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASP 3017
Query: 1040 ITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKR 1099
+NL E ++L+ Q ND E Q E +++Q ++ +L EE
Sbjct: 3018 DGSQNLVYETELLRTQ-------LNDSLKEIHQK-ELRIQQLNSNFS--QLLEEKNTLSI 3067
Query: 1100 EIQDLSKTVERLQKDRRMMLSNQN--SKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSK 1157
++ D S+++ Q+ +L++ K +E+ A DV + N D +
Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPE 3127
Query: 1158 LYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVK 1212
+ + S + L + NEL L+ E+ + ++ +E ++ E +RR++
Sbjct: 3128 ELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 128 bits (321), Expect = 4e-29
Identities = 301/1531 (19%), Positives = 618/1531 (40%), Gaps = 230/1531 (15%)
Query: 10 DEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLG---TNVSY 66
D+EF+ F K L D FE K + + M ++ ++++ K D LG T +SY
Sbjct: 816 DQEFQNF-KTLHMD-FEQKYKMVLEENERMNQEIVN---LSKEAQKFDSSLGALKTELSY 870
Query: 67 LKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLE 126
KT++ + E++E E Q + + ++E + +++E +L +
Sbjct: 871 -KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 127 EQEEKEQF--FARLEKGLTSSIDYSRLNKELDSNDSTHFKALHS--------NQANAELT 176
E+++ +Q ++E+ S + +N +D+ + AL S N ++++
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR-NALESLKQHQETINTLKSKIS 988
Query: 177 DDEHENESKHEELAENYSDDFEDEYVGAP--------------LTTKDEEMPSKENSKSE 222
++ N E E D+F+ + VG KD E+ ++
Sbjct: 989 EEVSRNLHMEENTGET-KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 223 KIS------------VPKQEEEKTGMLANV-----------VLLDSLDSVAEVNLDEQDK 259
I + ++E+ KT + N+ +L D L E+ E++
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNH 1107
Query: 260 ITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDI 319
K L T + + + S ++ Q ++ + + K+ N +E++
Sbjct: 1108 AIKKEGELSR-TCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK---INEIENL 1163
Query: 320 KSSVKGHP--------------QENEENSKNISTMESDLPTVEELMKPIRIDSFGISGF- 364
K+ +K Q+ EN + + ++ + ++EL K + + G+
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Query: 365 ------DLQPVSSEKVA-----ERKET--EFFSSLPLKMNPNILSQDSQHVNLFFDKNDE 411
LQ K+A E +ET E S+ K I +QD + + K E
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT---KLQE 1280
Query: 412 NVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLS--QDDKINKTY 469
+ + E + P V EV+ T+E ++++ L + + T +S++L+ + +++
Sbjct: 1281 EIPVLHEEQELL----PNVKEVSETQETMNELEL-LTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 470 RSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLE 529
+ Q S EE ++ ++ K + A + L +R + S K +L
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEV----KHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Query: 530 KKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKT-ESCLSTRKKSENP 588
K ++ + + +S Q + K+ I+ L K ++ + S K+ ++
Sbjct: 1392 MKEKDN----ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 589 TETDSCIQFQTDSLGY-CGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKE- 646
+Q ++D L E K L + ++ A + + I +++ SEKE E
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 647 -------------LENKLEELKKQQEKELFKLNQDNYILQA--KLSSFEETNK-KQRWLH 690
L+NK++E+ +++E+ F + Q + + + +L F+E K K L
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQ--FNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 691 FGEAADPVTGEKLKQIQKEIQ-------EQETLLQGYQQENERLYNQVKDLQEQNKKNEE 743
E+ +L++ Q+EIQ E + + + Q E ++L K++ + K+++E
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 744 RMFK--------ENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQ 795
+ ++ E Q E+ LKEQ + + +E Q + L E+R
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVT 1685
Query: 796 KEKDSL--LEDIKRLKQD------KQALEVDFEKMK---------KERDQAKDQIAYVTG 838
KE+D L +E+ ++++D ++ + D EK + KE + D++ +
Sbjct: 1686 KERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 839 EKLYEI----KILEETH---KQEISRLQKRLQ----WYAENQELLDKDALRLREANEEIE 887
EK EI K LE ++ K + ++Q+ L+ E QE +DK + E +++
Sbjct: 1746 EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 888 KLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPA-- 945
++ ++E A+ K K + + +++V EME + K+ SL
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
Query: 946 -----LILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQ 1000
L LA + + +V ++++E L+ + + K+SL+ E + + ++IQ
Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ--ETKARDLEIQ 1923
Query: 1001 YE----QRLEQQEQLLACKLNQHDSPR---IKALEKELDDIKEAHQITVRNLE-AEIDVL 1052
E + L ++ + KL + S + I ++K+LD K+ Q ++ L+ E+ +L
Sbjct: 1924 QELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 1053 KHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKK-----REIQDLSKT 1107
+ + DV + K + + ++ Q E + + VR++ KK EI+ ++K
Sbjct: 1984 R---VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 1108 VERLQ--KDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ L+ K+ M +Q EM A+ + + K + L L +
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLRE----K 2096
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKAS 1225
S + E+L+ + + E L N L + E + + RVK + SL
Sbjct: 2097 CSRIKELLKRYSEMDDHYECL----NRLSLDLEKEIEFQKELSMRVKAN-----LSLPYL 2147
Query: 1226 HQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVRE- 1284
+ IEKL N + S + + +K+ + + + +E +K E + EV +
Sbjct: 2148 QTKHIEKLFTAN--QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQ 2205
Query: 1285 -------EILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQII 1337
+ LQ++ ELR+ K N ++ H + K + E + E QQ++
Sbjct: 2206 KELLIKIQHLQQDCDVPSRELRDLKLNQNMDL-HIEEILKDFSESEF--PSIKTEFQQVL 2262
Query: 1338 QQTHQVVE-----TEQNKEVEKWKRLAQLKN 1363
++ + ++EK K Q +N
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN 2293
Score = 106 bits (264), Expect = 2e-22
Identities = 253/1301 (19%), Positives = 534/1301 (41%), Gaps = 197/1301 (15%)
Query: 184 SKHEELAENYSDDFED---EYVGAPLTTKDEEMPSKENSK--SEKISVPKQEEEKTGMLA 238
S E L + Y + D + L T+ + M + ++ EK + K + EK L
Sbjct: 339 STDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLT 398
Query: 239 NVVLLDSLDSVAEVNLDEQDKITPKPR---CLPEMTENEMTGTGVSYGQSSSDVEALHQA 295
+++ S + L ++ K K R CL ++ + + + + ++ H+
Sbjct: 399 RMLVTSS-----SLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL 453
Query: 296 YCHIAHSLGDE--DKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKP 353
++ + + + + SNT++ + S ++ +P N +NI ES+L ++
Sbjct: 454 SINLLREIDESVCSESDVFSNTLDTL-SEIEWNPATKLLNQENI---ESELNSLRA---- 505
Query: 354 IRIDSFGISGFDLQPVSSE---KVAERKETEFFSSLPLKMNPN----ILSQDSQHVNLFF 406
D+ + L+ E K+ E+ + + F +L K + ++ + S NL
Sbjct: 506 -DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVK 564
Query: 407 DKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKIN 466
N L+ + +E + ++ +E++D L ++ ++ + S+ ++
Sbjct: 565 HAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK 624
Query: 467 KTYRSQ----LSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPL 522
+T L ++ E A + RS LK K + ++ Y + + +
Sbjct: 625 QTLFDAETVALDAKRESAFL---------RSENLELKEKMKE------LATTYKQMENDI 669
Query: 523 KMF-STLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLST 581
+++ S LE K + K L+S N+ K L K+ K + + L
Sbjct: 670 QLYQSQLEAKKKMQVDLEKELQS--AFNEITKLTSLIDGKVPKDLLCNLELEGKITDL-- 725
Query: 582 RKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFS 641
+K+ E + ++ + L E K + + +E +DK + + FS
Sbjct: 726 QKELNKEVEENEALREEVILLS---ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS 782
Query: 642 E---KEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPV 698
E KE ++ LEE+ K K+ Q NY K + E N K + F + V
Sbjct: 783 EVVHKESRVQGLLEEIGKT--KDDLATTQSNY----KSTDQEFQNFKTLHMDFEQKYKMV 836
Query: 699 TGE------KLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSL 752
E ++ + KE Q+ ++ L + E L + ++LQE+ ++ +ER+
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTE---LSYKTQELQEKTREVQERL------- 886
Query: 753 FSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDK 812
+E+ LKEQ+ Q VE E + ++ LE++K L Q+K
Sbjct: 887 -NEMEQLKEQLENRDSTLQTVE--------------REKTLITEKLQQTLEEVKTLTQEK 931
Query: 813 QALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELL 872
L+ E ++ ERDQ K I + +T +Q L+ L+ ++QE +
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNI-------DTQEQ----LRNALESLKQHQETI 980
Query: 873 DKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAAD--AKKIQDLERQVKE 930
+ ++ +EE+ + L +E+ E+ +QK+ DK D AK Q L VK+
Sbjct: 981 NTLKSKI---SEEVSR-NLHMEENTGET-KDEFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035
Query: 931 MEGILKRR-------YPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDA 983
E I ++R N L ++ + A + + + E +E I+ E +L ++
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE-ELRLLGDEL 1094
Query: 984 KKSLRTMEQQ---------------------FQKMKIQYEQRLEQQEQLLACKLNQHD-S 1021
KK + Q+ +K+K + +Q E+Q+QLL + +
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 1022 PRIKALEKELDDIKEAHQITVRNLEAE-IDVLKHQNAEL-DVKKNDKDDEDFQSIE--FQ 1077
+I +E +++K ++T+ ++E E +++ + N +VK K+ + + ++ F+
Sbjct: 1155 KKINEIENLKNELKN-KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE 1213
Query: 1078 VEQAHAKAKL-------VRLNEELAAKKREIQDLSKTVERLQKD---------RRMMLSN 1121
E+ H + + ++ EEL +++ +T++ L++ L
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273
Query: 1122 QNSKGREEMSAKRAKKDVLHSSK--GNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRL 1179
++K +EE+ ++++L + K L+ Q T + ++ + E RL
Sbjct: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
Query: 1180 -------KNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEK 1232
+ E++ L E++ LK EA+ E ++KE +A ++ S ++ +
Sbjct: 1334 NEKFQESQEEIKSLTKERDNLKTIKEAL----EVKHDQLKEHIRETLAKIQESQSKQEQS 1389
Query: 1233 LLCQNAVENSSSKVAELNRKIATQEVLIR----------HFQSQVNELQSKQESLVVSEV 1282
L + ++ V+E+ + L+R Q +E++S + +
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 1283 REEILQKEITKLLEELRE--AKENHTPE---MKH--FVGLEKKIKQMEMRHAQREQELQQ 1335
+E+LQ E +L E ++E AK T E + H E+ I ++ + +++E E+
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509
Query: 1336 IIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSI 1376
I +Q + + QNK E +++ Q +++ + + +++ +
Sbjct: 1510 IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550
Score = 96.3 bits (238), Expect = 2e-19
Identities = 265/1430 (18%), Positives = 567/1430 (39%), Gaps = 223/1430 (15%)
Query: 6 QEELDEEFEQFMKELSDDSFENSDKTARQSKK-EMKKKDTVPWWITED----DFKDDGLL 60
+E L+ + +Q + + + + + ++Q + MK+KD I + KD LL
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 61 GTNVSYLK-TKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETN--ELVVSELN-HS 116
+ L +K+ + E++ + EK + +D L+ N E+V L
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE 1477
Query: 117 SLGVGLDTLEEQEEKEQFFARLEKGLTSS-IDYSRLNKELDS-NDSTHFKALHSNQANAE 174
L V L+EQEE L L+ + S + K+L++ ND K + +
Sbjct: 1478 ELKVAHCCLKEQEET---INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Query: 175 LTDDE-HENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEK 233
+ E + K EL + + + +K E+ ++ E+I + +E+E+
Sbjct: 1535 FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
Query: 234 TGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALH 293
+ + ++ D + E +I K + E + T V+ Q
Sbjct: 1595 MKRVQEALQIER-DQLKE----NTKEIVAKMKESQEKEYQFLKMTAVNETQ--------- 1640
Query: 294 QAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKP 353
+ C I H + QK+ +E + EN E ++++ DL +VEE +K
Sbjct: 1641 EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKV 1700
Query: 354 IRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVN----LFFDKN 409
R E + E + LK+ L + + ++ + +K
Sbjct: 1701 ERDQL------------KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1748
Query: 410 DENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTY 469
+E +QK S + Q ++ +E + ++++ ++ T++ +K +K
Sbjct: 1749 NEISNMQKDLEHSNDALKAQDLKI---QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 470 RSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLE 529
Q E A + +++ KA TL+
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANE-----------------------------HQLITLK 1836
Query: 530 KKTSEDIIKSKNLRSISTSNQPRKKEILSGTKL-IKPAALDKPAHKT-ESCLSTRKKSEN 587
K +E K + + + K + L+ +KL I+ L + H+ E S K+ +N
Sbjct: 1837 KDVNET---QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 588 PTETDSCIQFQTDSLGYC-GENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEK--- 643
+ ++ + D L E K + L + + ++ A + + +++++ SEK
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 644 ----EKELENKLEELKKQ----QEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAA 695
+K+L+ +EL+K+ Q+KEL +L+ K E+ N + ++
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKEL-------QLLRVK----EDVNMSHKKIN----- 1997
Query: 696 DPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ-----NKKNEERMFKENQ 750
+++Q++K+ + Q +Q + +N +L ++ + E+ +++E R KE+
Sbjct: 1998 ------EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESL 2051
Query: 751 SLFSE--VASLKEQMHKSRFLSQVVEDSEPTRN--QNFTDLLAE-------LRMAQKEKD 799
+ + +A+L+E + + R QV + + Q+ T+ L E L E D
Sbjct: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111
Query: 800 SLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQ 859
E + RL D + E++F+K R +A + Y+ + + ++ + E R+
Sbjct: 2112 DHYECLNRLSLDLEK-EIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM 2170
Query: 860 KRLQWYA--------ENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
K+L++ E E ++K + + E+ ++L ++I+ L+ + PS +++R
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPS--RELR- 2227
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
D K Q+++ ++E ILK +F E
Sbjct: 2228 -----DLKLNQNMDLHIEE---ILK--------------------------DFSESEFPS 2253
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQ-KMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKE 1030
++ + + + K+ + +E+ + I+ + Q+E C++N + RI A+ E
Sbjct: 2254 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
Query: 1031 LDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRL 1090
+ +E + E ++ LK +KN+K +++Q+++ + +
Sbjct: 2314 STEFEERSATISKEWEQDLKSLK--------EKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365
Query: 1091 NEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSF 1150
N+ R Q T E++++ L N + +E K +K + N
Sbjct: 2366 NKNPHVTSRATQ---LTTEKIRE-----LENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417
Query: 1151 PGTLDSKLYQPHTFTD--SHVSEVLQENYRL-----KNELEGLISEKNELKMKSEAV-MN 1202
L +K+++ + + +VLQ+ L K E+E +LKMK + +
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE-------DLKMKLVKIDLE 2470
Query: 1203 QFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVEN----SSSKVAELNRKIATQEV 1258
+ +N+ KE +A +Q+E+ +LL +N + +S ++E + +
Sbjct: 2471 KMKNAKEFEKEISA---TKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
Query: 1259 LIRHFQSQVNELQSKQESLVVSE-VREEILQKEITKLLEELREAKENHTPEMKHFVGLEK 1317
L S + +Q+ + ++ SE +R L+KEI+KL ++ + + + + L
Sbjct: 2528 LTCGGGSGI--VQNTKALILKSEHIR---LEKEISKLKQQNEQLIKQKNELLSNNQHLSN 2582
Query: 1318 KIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELE 1367
++K + R +RE Q + + + + +K +Q K R L+
Sbjct: 2583 EVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632
Score = 76.3 bits (186), Expect = 2e-13
Identities = 157/741 (21%), Positives = 297/741 (40%), Gaps = 133/741 (17%)
Query: 741 NEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDS 800
N+E + E SL ++ +L + R + +E +N E + + ++
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551
Query: 801 LLEDIKRLK----------QD-KQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEE 849
L+ +I LK QD + L E ++++ DQ K Y+ +KL IK ++
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIK-MDL 610
Query: 850 THKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKI 909
++ E K+++ + E + DA R A E L+L+ + + + + I
Sbjct: 611 SYSLESIEDPKQMKQTLFDAETVALDAKR-ESAFLRSENLELKEKMKELATTYKQMENDI 669
Query: 910 RLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRI 969
+L +AK K+M+ L++ ++ + S V K+ +
Sbjct: 670 QLYQSQLEAK---------KKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLL------- 713
Query: 970 KKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEK 1029
+LEGK D +K L ++ + ++ +E +L +L S ++ L K
Sbjct: 714 --CNLELEGKITDLQKELNKEVEENEALR---------EEVILLSELKSLPS-EVERLRK 761
Query: 1030 ELDD-IKEAHQIT----------------VRNLEAEIDVLKHQNA--ELDVKKNDKDDED 1070
E+ D +E H IT V+ L EI K A + + K D++ ++
Sbjct: 762 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQN 821
Query: 1071 FQSIEFQVEQAHAKAKLV-----RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSK 1125
F+++ EQ K K+V R+N+E+ +E Q ++ L+ + K
Sbjct: 822 FKTLHMDFEQ---KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878
Query: 1126 GRE------EMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRL 1179
RE EM + + + S+ + KL Q T V + QE L
Sbjct: 879 TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ----TLEEVKTLTQEKDDL 934
Query: 1180 KNELEGLISEKNELKMKSEAVMN-------QFENSMRRVKEDTAAHIASLKASHQREIEK 1232
K E L E+++LK +N Q N++ +K+ I +LK+ E+ +
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET-INTLKSKISEEVSR 993
Query: 1233 LLCQN-----------------------AVENSSSKVAEL-NRKIATQEVLIRHFQSQVN 1268
L +N+ + A++ + +I Q+ I + N
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 1269 ELQSKQESLVV------SEVREEI-----LQKEITKLLEELREAKENHTPEMKHFVGLE- 1316
ELQ ES++ ++++E I Q+E+ L +EL++ +E E H + E
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
Query: 1317 ------KKIKQMEMRHAQREQELQQIIQQTHQVVE--TEQNKEVEKWKRLA-QLKNRE-- 1365
++ ++E + ++ Q+LQ+ QQ V E +E K++ + + L +LKN+E
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELT 1173
Query: 1366 LEKFRTELDSILDVLRELHRQ 1386
LE TE + L E + +
Sbjct: 1174 LEHMETERLELAQKLNENYEE 1194
Score = 65.1 bits (157), Expect = 5e-10
Identities = 118/587 (20%), Positives = 244/587 (41%), Gaps = 91/587 (15%)
Query: 840 KLYEIKILEETHKQEISRLQKRLQWYAENQ--ELLDKDALRLREANEEIEKLKLEIEKLK 897
K Y +I++ + E L+ R Q ++Q +LL++ L + NE+IE L ++
Sbjct: 346 KRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLT----RML 401
Query: 898 AESGNPSIRQKIRLKDKAA--------DAKKIQDLERQVKEMEGILKRRYPNSLPAL--I 947
S + +++Q+++ K K + K + Q I + + S+ L I
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 948 LAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQ 1007
+ + V NT++ + + I+ A E+ + L ++ + + + YEQ +
Sbjct: 462 DESVCSESDVFSNTLDTLSE-IEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 1008 QEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKD 1067
+E++ ++D +ALE++ +E I EI LK+ +V D +
Sbjct: 521 KEEMELKLKEKNDLDEFEALERKTKKDQEMQLI------HEISNLKNLVKHAEVYNQDLE 574
Query: 1068 DEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGR 1127
+E +K +L+R E+ K +E D S+ +E ++ D L
Sbjct: 575 NE-----------LSSKVELLREKEDQIKKLQEYID-SQKLENIKMDLSYSL-------- 614
Query: 1128 EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLI 1187
E + + K L ++ A LD+K + F S EN LK +++ L
Sbjct: 615 ESIEDPKQMKQTLFDAETVA------LDAK--RESAFLRS-------ENLELKEKMKELA 659
Query: 1188 SEKNELKMKSEAVMNQFEN------SMRRVKEDTAAHIASLKASHQREIEK-LLCQNAVE 1240
+ +++ + +Q E + + + I L + ++ K LLC +E
Sbjct: 660 TTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELE 719
Query: 1241 NSSSKV-AELNRKIATQEVL---------IRHFQSQV----NELQSKQESLVV-----SE 1281
+ + ELN+++ E L ++ S+V E+Q K E L + +
Sbjct: 720 GKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK 779
Query: 1282 VREEILQKE--ITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQ 1339
+ E++ KE + LLEE+ + K++ ++ +++ + + H EQ+ + ++++
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839
Query: 1340 THQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQ 1386
++ N+E+ + AQ + L +TEL L+E R+
Sbjct: 840 NERM-----NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE 881
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 126 bits (317), Expect = 1e-28
Identities = 188/826 (22%), Positives = 377/826 (45%), Gaps = 112/826 (13%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEK-ELENKLEELKKQQE---KEL 662
E KE ++ + ED+ G +A +++ EKE +L+ KL +++ +++ K++
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL--EKENLQLKAKLHDMEMERDMDRKKI 405
Query: 663 FKLNQDNYILQ-AKLSSFEETNKKQRWLHFGEAADPV--TGEKLKQIQKEIQEQ-----E 714
+L ++N L+ A+ S +E+ LH G + + T E + QK + +
Sbjct: 406 EELMEENMTLEMAQKQSMDES------LHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 715 TLLQGYQQENERLYNQVKDLQ------EQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
+ L + EN+ L V++L+ E N +M KENQ L +V L+
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE-------- 511
Query: 769 LSQVVEDSEPTRN-QNFT-DLLAELRMAQKEKDSLLED----IKRLKQDKQALEVDFEKM 822
+++V++ + +N QN + DL+ E +K ++L E+ IK L+Q+ + L +
Sbjct: 512 -NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 823 KKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRL----------QKRLQWY---AENQ 869
+ +R Q + EK E KIL E+ K+ S+L +K L+ Y E
Sbjct: 571 R-QRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 870 ELLDKDALRLREANEEIEK----LKLEIEKLKA-ESGNPSIRQKIRLKDKAADAKK---- 920
E L+ + L + NE ++K LK+ EK++A E N + ++ R K D+ K
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 921 -IQDLERQVKEM--EGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLE 977
++ LE++ ++ E + RR SL + + +++ +LE
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCASMKMA----------------QLQLENKELE 731
Query: 978 GKDEDAKKSLRTMEQQFQK---MKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDI 1034
+ E KK L ++ F+K +++ Y Q L+ + Q L K ++ + +I+ LE EL D+
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSY-QGLDIENQRLQ-KTLENSNKKIQQLESELQDL 789
Query: 1035 KEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEEL 1094
+ +Q +NLE E+ + + +L+ K+N +++ +E +Q + K RL ++
Sbjct: 790 EMENQTLQKNLE-ELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENK--RLRQQA 845
Query: 1095 AAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTL 1154
K +++ + + L+K+ + + + K +K+ K T+
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR------ATI 899
Query: 1155 DSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKED 1214
D K T + VSE L+ ++ N+LE L E ++ + E +++ +++ R K
Sbjct: 900 DIKTLV--TLREDLVSEKLKTQ-QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 1215 TAAHIASLKASHQREIEKLLCQNA-VENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK 1273
+ ++LK S + + EK+ A +E S++ +L +++ T + + + +E +
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 1274 QESLVVS------EVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHA 1327
Q S +S E + +E+ K+ + L E + N+ L+ ++KQ+E ++
Sbjct: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
Query: 1328 QREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTEL 1373
+ ++ + +QT V EQN ++ Q++N L T L
Sbjct: 1077 NLQAQILALQRQT--VSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120
Score = 108 bits (271), Expect = 3e-23
Identities = 212/940 (22%), Positives = 397/940 (42%), Gaps = 161/940 (17%)
Query: 555 EILSGTKLIKPAALDKPAHKTESCLSTRK---KSENPTETDSCIQFQTDSLGYCGENKEK 611
E +S T + A H+ S+R + EN + T + + +T G N K
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG-NASK 492
Query: 612 KLLMFKRVQEAEDKWRGAQALIEQIKATFSE---------KEK-ELENKLEELKKQQEKE 661
L M K Q K + I Q K + KEK +LE +E L++ E++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 662 LFKLNQDNYILQAKLSSFEETN------------KKQRWLHFGEAADPVTGEKLKQIQKE 709
+ L Q+N L +SS + + K+ + LH + T KL +I+ E
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH---ESIKETSSKLSKIEFE 609
Query: 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNE----------------ERMFKENQSLF 753
++ + L+ Y+++ ER +L K+NE E + +EN L
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 754 SEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLL-----------AELRMAQK--EKDS 800
E LK+ + + L+ +E E +Q + L A ++MAQ E
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQK 860
L + ++LK+ + L+ F+K ER + Q + ++L K LE ++K+ I +L+
Sbjct: 730 LESEKEQLKKGLELLKASFKKT--ERLEVSYQGLDIENQRLQ--KTLENSNKK-IQQLES 784
Query: 861 RLQWYAENQELLDKDALRLREANEEIEKLK------------LEIEKLKAESGNPSIRQK 908
LQ + L K+ L+ +++ +E+L+ LE +K + E N +RQ+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 909 IRLKDKAADAK--KIQDLERQVKEME---GILKRRYPNSLPALILAASAAGDTVDKNTVE 963
+KD + KI +LE++ K + GI Y S L + V + T++
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGI----YKESCVRLKELEKENKELVKRATID 900
Query: 964 FMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPR 1023
K + L DL + K + M +K+ + E+ +E+LL + + D R
Sbjct: 901 I--KTLVTLREDLVSE----KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD--R 952
Query: 1024 IKALEKELDD-IKEAHQIT---VRNLEAEIDVLKHQNAEL-----DVKKNDKDDEDFQSI 1074
K LE +L+ +K++ +I + LEA ++ + N +L VKKN + + Q
Sbjct: 953 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1012
Query: 1075 EFQVEQAHAKA----KLVRLNEELAAKKREIQDLSKTVER----LQKDRRMM------LS 1120
E V+ + + K R ++E + +++D VER LQ +++ + L
Sbjct: 1013 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072
Query: 1121 NQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRL- 1179
QN+ + ++ A + + L N+ T ++KL ++ +S + ++ +N +L
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQ----NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1128
Query: 1180 ------KNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQR---EI 1230
+NE E +I E+ +LK ++++ E L+ H+R E
Sbjct: 1129 IQQSSLENENESVIKEREDLKSLYDSLIKDHE---------------KLELLHERQASEY 1173
Query: 1231 EKLLCQNAVENSSSKVAEL-NRKIATQEVLIRHFQSQVNELQS----KQESLVVSEVREE 1285
E L+ ++ S+ K E+ +R + + + + Q+ +L+ +QE +++ E
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1233
Query: 1286 ILQKEITKLLEELREAKENHTPEMKHFVGLE---KKIKQM----EMRHAQREQELQQIIQ 1338
+ E KL E ++ +K L+ K +K + ++ + E E ++ +
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 1339 QTHQ--VVETEQNKEVEKWKRLAQLKNRELEKFRTELDSI 1376
Q Q + T+ N + E L+QLK E+ R LD I
Sbjct: 1294 QYQQLDITSTKLNNQCE---LLSQLKGNLEEENRHLLDQI 1330
Score = 94.7 bits (234), Expect = 5e-19
Identities = 161/742 (21%), Positives = 313/742 (42%), Gaps = 115/742 (15%)
Query: 702 KLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKK-----NEERMFKEN------- 749
K++++++E++E+ L +QE E++ ++K LQ++N RM+++
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 750 ----QSLFSEVASLKEQMHKSRFLSQVVEDSEPTRN---QNFTDLLAELRMAQKEKDSLL 802
L SEV+ KE++H F VE+ + + T L +L + D L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 803 EDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRL 862
E L+++ L+ M+ ERD + +I + E + +++ ++ E L L
Sbjct: 379 E----LEKENLQLKAKLHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLHLGWEL 433
Query: 863 QWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQ 922
+ + EL + L E+ +L LK E N S+ K ++
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRL----LKLEMENQSL------------TKTVE 477
Query: 923 DLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDED 982
+L V +EG + IL + K VE +E I + + L+ ++
Sbjct: 478 ELRTTVDSVEGNASK---------ILKMEKENQRLSKK-VEILENEIVQEKQSLQNC-QN 526
Query: 983 AKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITV 1042
K L + Q +K + E+Q ++L + N+H + + +L + EA V
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQE-NEHLNQTVSSLRQRSQISAEAR---V 582
Query: 1043 RNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQ 1102
+++E E +L H++ + K K + F+ + + E H K K R E + E+
Sbjct: 583 KDIEKENKIL-HESIKETSSKLSKIE--FEKRQIKKELEHYKEKGERAEE----LENELH 635
Query: 1103 DLSKTVERLQKD-RRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQP 1161
L K E LQK + ++ + + E+ +++ +++ TLDS ++
Sbjct: 636 HLEKENELLQKKITNLKITCEKIEALEQENSELEREN---------RKLKKTLDS--FKN 684
Query: 1162 HTFT----DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMN-QFENSMRRVKEDTA 1216
TF + S++ +EN L+ +E L + +KM + N + E+ ++K+
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESL--KCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 1217 AHIASLKASHQRE-------IEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE 1269
AS K + + E IE Q +ENS+ K+ +L ++ E+ + Q + E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 1270 LQSKQESLVVSEVREEILQKEITKL-------------LEELREAKENHTPEMKHFVG-L 1315
L+ + L E + L++E ++L L + E K+ E +G L
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 1316 EKKIKQME----------MRHAQREQELQQIIQQTHQVVET--EQNKEVEKWKRLAQLKN 1363
EK+ K + +R + E+E ++++++ ++T +++ K Q N
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 1364 RELEKFRTELDSI-LDVLRELH 1384
+LEK EL+ I L+ R LH
Sbjct: 923 NDLEKLTHELEKIGLNKERLLH 944
Score = 67.8 bits (164), Expect = 7e-11
Identities = 96/435 (22%), Positives = 193/435 (44%), Gaps = 49/435 (11%)
Query: 976 LEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD-SPRIKALE---KEL 1031
++G D D K ++ Q+ ++ + + + ++Q D P +K + K L
Sbjct: 145 IQGLDFDTKAAVAAHIQEVT----HNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRL 200
Query: 1032 DDIKEAHQITVRNLEAEID---VLKHQNAELDVKKNDKDDEDFQSIE-FQVEQAHAKAKL 1087
D ++ H T+ L E D L H ++ + +S + VE A AKAK+
Sbjct: 201 IDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKI 260
Query: 1088 VRLNEELAAK-------KREIQDLSKTVERLQKDRRMMLSNQNSKG--REEMSAKRAKKD 1138
RL +EL K K+E++ + ++RLQ++ +LS+ S R+E+ A R K
Sbjct: 261 RRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV 320
Query: 1139 VLHSSKGNANSFPGTL-DSKLYQPHTFTDSHVSEVLQE-NYRLKNELEGLIS-------- 1188
+ + + + L D + Y+ ++VL E L+++LEG +
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380
Query: 1189 EKNELKMKSEAVMNQFENSMRRVK-EDTAAHIASLKASHQREIEKLLCQNAVENSSSKVA 1247
EK L++K++ + E M R K E+ +L+ + ++ +++ L + ++
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL------HLGWELE 434
Query: 1248 ELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTP 1307
+++R E + +VNEL S + ++ E+ + +TK +EELR ++
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 1308 EMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELE 1367
+ +EK+ R +++ + L+ I Q Q ++ QN + K AQL+ + +E
Sbjct: 489 NASKILKMEKE----NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE-KTIE 543
Query: 1368 KFRTELDSILDVLRE 1382
R + + +L +
Sbjct: 544 TLRENSERQIKILEQ 558
Score = 65.9 bits (159), Expect = 3e-10
Identities = 182/949 (19%), Positives = 357/949 (37%), Gaps = 121/949 (12%)
Query: 63 NVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELN-HSSLGVG 121
N S KT + + ++ E +A KI ++ L + NE+V + + + +
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 122 LDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
D ++E+ + E+ L + I E + + + A A + D E E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 182 NESKHEELAENYSD----DFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML 237
N+ HE + E S +FE + L E+ E ++E + K+ E +
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 238 ANV-VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAY 296
N+ + + ++++ + N + E ++ T S+ + +E+L +
Sbjct: 649 TNLKITCEKIEALEQENSEL------------ERENRKLKKTLDSFKNLTFQLESLEKEN 696
Query: 297 CHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQ---ENEENSKNISTMESDLPTVEELMKP 353
+ DE+ ++ N VE +K + Q EN+E ++ L ++ K
Sbjct: 697 SQL-----DEENLELRRN-VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Query: 354 IRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENV 413
G D++ +K E + L ++ QD + N KN E +
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKI-QQLESEL------QDLEMENQTLQKNLEEL 803
Query: 414 ILQKTTNESMENSCPQVTEVTATEEHVDKMYLNI----LRKKITVNSSSLSQD------- 462
+ E +E + + T+ E DK L LR++ + ++L ++
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEK-DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 463 DKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKP-QSGLYASVRSSGYGKPSSP 521
+K NKT ++ +E V K++ + L+KR ++R +
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKE----LVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 522 LKMFSTLEKKTSE----DIIKSKNLRSISTSNQPRK--KEILSGT-------KLIKPAAL 568
+M + LEK T E + K + L +++ K + L T K K AAL
Sbjct: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978
Query: 569 D-----------------KPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+ K K L R+ E ++ I + + + +
Sbjct: 979 EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
Query: 612 KLLMFK-RVQEAEDKWRGAQALIEQIKATFSEKEKELEN-------------KLEELKKQ 657
+LL K R+ E E QA + +K + E + N L+E
Sbjct: 1039 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1098
Query: 658 QEKELFKLNQDNYILQAKLSSFEETNKK----QRWLHFGEAADPVTGEKLKQIQ----KE 709
+ + KL +N L ++ +S N + Q L + E LK + K+
Sbjct: 1099 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD 1158
Query: 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFL 769
++ E L + E E L ++ L+ +K N E ++ + ++++ K Q+ +
Sbjct: 1159 HEKLELLHERQASEYESLISKHGTLKSAHK-NLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1217
Query: 770 SQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMK-----K 824
+V ++ N+N + AE + E D L +L ++ + L+ D + +K
Sbjct: 1218 LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNS 1277
Query: 825 ERDQAKDQIAYVTGEKLYEIKILEETHKQE----ISRLQKRLQWYAENQELLDK------ 874
+ +Q + + + ++ Y+ + T +S+L+ L+ EN+ LLD+
Sbjct: 1278 KLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE--EENRHLLDQIQTLML 1335
Query: 875 DALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQD 923
L E N E + L ++ + N RQK +L++K D K D
Sbjct: 1336 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1384
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 124 bits (312), Expect = 5e-28
Identities = 210/953 (22%), Positives = 422/953 (44%), Gaps = 154/953 (16%)
Query: 529 EKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENP 588
E K + + L +++ + E+ + +K K ALD+ + K + T++ +
Sbjct: 1940 ENKQKVIVCLEEELSVVTSERNQLRGELDTMSK--KTTALDQLSEKMKE--KTQELESHQ 1995
Query: 589 TETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEK--- 645
+E CIQ E KEK L+ + + + L E++++ + +
Sbjct: 1996 SECLHCIQVAE------AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049
Query: 646 ---ELENKLEELKKQQEKELFKLNQDNYILQAKLSS--FEETNKKQRWLHFGEAADPVTG 700
ELEN++ +L K EKEL L +++ LQA+LS +E+ N + EAA G
Sbjct: 2050 TKCELENQIAQLNK--EKEL--LVKESESLQARLSESDYEKLNVSKAL----EAALVEKG 2101
Query: 701 EKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLK 760
E ++ +E L +G ++ R+ K +K +ER +EN SL +V +L+
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERE-RENDSLKDKVENLE 2160
Query: 761 EQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFE 820
++ S NQ L AE A+ E +L I+ + + + E+D
Sbjct: 2161 RELQMSE------------ENQELVILDAENSKAEVE--TLKTQIEEMARSLKVFELDLV 2206
Query: 821 KMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLR 880
++ E++ QI G+ K+L + Q +Q E++ ++ +L+
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
Query: 881 EANEEIEKL--KLEIEKLKAESGNPSIRQKIRLKDKA--------ADAKKIQDLERQVKE 930
E NE + L EI K +S +P I ++ +L++ AD KK + +Q+KE
Sbjct: 2267 ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 931 ME---GILKRRYPN-----------SLPALILAASAAGDTVD-KNTVEFMEKRIKKLEAD 975
E +LK R N A + A ++ G+ K +E M + ++ LE D
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELD 2386
Query: 976 ---LEGKDEDAKKSLRTMEQQFQKMKI---QYEQRLEQQEQLLACKLNQHDSPRIKALEK 1029
+ + E+ L+ +++ +++I +E L+++EQ ++ + S ++ L+
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-QMKEKSSTAMEMLQT 2445
Query: 1030 ELDDI----------KEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQV- 1078
+L ++ +EA + +NL ++++ L+ + A+L ++ D+ ++ ++ V
Sbjct: 2446 QLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL-LQGLDEAKNNYIVLQSSVN 2504
Query: 1079 ----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQ---------KDRRMMLSNQNSK 1125
E K KL + +EE++ K +IQD + V +L K++ + L N +
Sbjct: 2505 GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE 2564
Query: 1126 GREEMSAKRAKK-------DVLHSSKGNAN-----------SFPGTLDSKLYQPHTFTDS 1167
+++ ++K +VL SS N SF + +K+ T
Sbjct: 2565 LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV-NKMTAKETELQR 2623
Query: 1168 HVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHI---ASLKA 1224
+ E+ Q+ L+ EL G EKN L + + ++ + ++S ++KE T + SL
Sbjct: 2624 EMHEMAQKTAELQEELSG---EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
Query: 1225 SHQREIEKL-LCQNAVENSSSKVAELNRK-----IATQEVLIRHFQSQVNELQSKQESLV 1278
H+ ++EK + + ++ E +K + T + Q+ +L SK+E L
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740
Query: 1279 VSEVREEILQ----------KEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQ 1328
++ ++L+ K T++LEEL++ K ++ K + Q++ + +
Sbjct: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL----------KYVNQLKKENER 2790
Query: 1329 REQELQQIIQQTHQVVETEQNKEVEKWKRLAQLK-NRELEKFRTELDSILDVL 1380
+ +++ +I+ Q+ E+ KE+ + K L+QL+ +E +K T +D+ +D L
Sbjct: 2791 AQGKMKLLIKSCKQL---EEEKEILQ-KELSQLQAAQEKQKTGTVMDTKVDEL 2839
Score = 118 bits (295), Expect = 5e-26
Identities = 162/795 (20%), Positives = 343/795 (43%), Gaps = 99/795 (12%)
Query: 642 EKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEE-----TNKKQRWLHFGEAAD 696
+K +ELE +L++LKK++++ F+L+ LQ + E TN K+ E +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 697 PVTGEKLKQ-IQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSE 755
+ EK KQ I E+Q +E+ + + + Q++ L+++ K+ + + + Q+ S
Sbjct: 78 SL--EKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
Query: 756 VASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQAL 815
SL + + + S+ + DL + +E+ L ++K L Q K+A
Sbjct: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKAS 194
Query: 816 EVDFEKMKKERDQAKDQIA---YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELL 872
+ + RD A+ Q + + ++ + + + I R + E +
Sbjct: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTP 254
Query: 873 DKDALRL--REANEE----------IEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKK 920
+ L++ R+AN +++LK + ++L+ + +R + K+ K
Sbjct: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
Query: 921 IQDLERQVKE--MEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEG 978
Q+L+ Q+++ +E I K + N ++ +A D +E+++KKL DL
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA-LEQKLKKLTEDLSC 373
Query: 979 KDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAH 1038
+ ++A+ + ++EQ+ ++ + ++++ L +Q++ L+Q L +EL K H
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ-TLDQECIQMKARLTQELQQAKNMH 432
Query: 1039 QITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKK 1098
+ L+AE+D L +L + + E+F K KL R + A +
Sbjct: 433 NV----LQAELDKLTSVKQQL-----ENNLEEF------------KQKLCRAEQAFQASQ 471
Query: 1099 REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKL 1158
+ +L +++E ++K+ ++ S+ K RE + K++ + N F + +K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN-FAEEMKAKN 530
Query: 1159 YQPHTFTDSHVSEVLQENYRLKNE--------LEGLISEKNELKMKSEAVMNQFENSMRR 1210
T ++ Q+ L E LE +L K E + Q + + +
Sbjct: 531 TSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSK 590
Query: 1211 VKEDTAAHIASLKASHQR----------------EIEKLLCQ--NAVENSSSKVAELNRK 1252
++++ A +++L+ + E EKLL Q + EN SK+ L
Sbjct: 591 TEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
Query: 1253 IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHF 1312
+ TQ++ + +V L+ +E+L V EI L L + +
Sbjct: 651 LKTQQIKSHEYNERVRTLEMDRENLSV----------EIRNLHNVLDSKSVEVETQKLAY 700
Query: 1313 VGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFR-- 1370
+ L++K + + +H ++E++ + +T Q+ T Q +++E +L L N ++K R
Sbjct: 701 MELQQKAEFSDQKH---QKEIENMCLKTSQL--TGQVEDLE--HKLQLLSNEIMDKDRCY 753
Query: 1371 ----TELDSILDVLR 1381
E +S+ D+L+
Sbjct: 754 QDLHAEYESLRDLLK 768
Score = 101 bits (252), Expect = 4e-21
Identities = 168/851 (19%), Positives = 350/851 (41%), Gaps = 144/851 (16%)
Query: 634 EQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGE 693
E + + +K KE E + +E +Q++ L+Q+ ++A+L+ + K + E
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
Query: 694 AADPVTGEK------LKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQN---KKNEER 744
D +T K L++ ++++ E Q Q + L +++++++N K + E+
Sbjct: 439 L-DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 745 MFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLED 804
+E L +E+ ++K+ +++S+ ++ ++ ++ DL ++ Q+E LE
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN--QQENSLTLEK 555
Query: 805 IKR---------------LKQDKQALEVDFEKMKKERDQAKDQIAYVT-----GEKLYEI 844
+K LK+ + +E +K+ K ++K ++ + E+L E
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 845 KILEETHKQEISRLQKRLQWYAEN--------QELLDKDALRLREANEEIEKLKLEIEKL 896
K L K E +L +++ EN + L ++ E NE + L+++ E L
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 897 KAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDT 956
E N + + K + +K+ +E Q K +++ + + L S
Sbjct: 676 SVEIRN--LHNVLDSKSVEVETQKLAYMELQQKAE--FSDQKHQKEIENMCLKTSQLTGQ 731
Query: 957 VD---------KNTVEFMEKRIKKLEAD-------LEGKD------EDAKKSLRTMEQQF 994
V+ N + ++ + L A+ L+ KD ED ++SL +QQ
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ- 790
Query: 995 QKMKIQYEQRLEQQEQLLA----CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEID 1050
M + + +Q + + C+L SP+ A+ Q V +LE ++
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL----------QNRVDSLEFSLE 840
Query: 1051 VLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKA-------------KLVRLNEELAAK 1097
K N++L K E+ I+ ++E+ KA ++ +L E+ +A
Sbjct: 841 SQKQMNSDLQ-----KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 1098 KREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLD-- 1155
+ + + +E +K+ +++ ++ E K++ +L S TL
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH-LLEDSLKELQLLSETLSLE 954
Query: 1156 -SKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKED 1214
++ + + E+ QEN LK L EK L KSE+ N + + + E
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISE- 1013
Query: 1215 TAAHIASLKASHQREIEKLL----CQ---NAVENSSSKVAELNRKIATQEVLIRH----F 1263
S Q + EKL+ C+ NA E+ S K K + E L+
Sbjct: 1014 ---------LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1264 QSQVNELQSKQES-----------LVVSEVREEILQKEITKLLEELR-EAKENHTPEMKH 1311
+++ NEL+ +E+ L +E R + L E+ + + LR E +N
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 1312 FVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----EVEKWKRLAQLKNRELE 1367
GL+++I ++ + ++E+ ++Q+ Q+++ + K +E +K RE E
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE 1184
Query: 1368 K----FRTELD 1374
+ F+ ++D
Sbjct: 1185 RNQCNFKPQMD 1195
Score = 98.2 bits (243), Expect = 5e-20
Identities = 215/976 (22%), Positives = 394/976 (40%), Gaps = 145/976 (14%)
Query: 499 KRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILS 558
K+ Q+ A++ + + +FS ++KT + + I + S
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPI---RRDFSASYFS 247
Query: 559 GTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKR 618
G + + P+ K ++ S S +P D ++ Q L NK +L + +
Sbjct: 248 GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ-LKAQNQEL----RNKINELELRLQ 302
Query: 619 VQEAE-----DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQ 673
E E +K++ Q +E+ K EKEK L NK + + + + + L+
Sbjct: 303 GHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTKYTALE 361
Query: 674 AKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKD 733
KL E QR E+A +K+K+ +KE QE+ + Q Q ++ Q+K
Sbjct: 362 QKLKKLTEDLSCQR--QNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
Query: 734 LQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRM 793
Q + + M Q+ ++ S+K+Q+ + + F L
Sbjct: 420 RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL--------------EEFKQKLCRAEQ 465
Query: 794 AQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQ 853
A + +++R E+MKKE + K + +K E+ LE K
Sbjct: 466 AFQASQIKENELRR----------SMEEMKKENNLLKSH----SEQKAREVCHLEAELK- 510
Query: 854 EISRLQKRLQWYAENQELLD-KDALRLREANEEI--EKLKLEIEKLKAESGNPSIRQKIR 910
I + + Q +AE + + LR+ E+I ++ L +EKLK ++ +
Sbjct: 511 NIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL-----AVADLEK 565
Query: 911 LKDKAADAKKIQDLERQVKEMEGILKRRYPNS---LPALILAASAAGDTVDKNTV-EFME 966
+D + D K + E ++++ L + S L AL L + ++ T+ +
Sbjct: 566 QRDCSQDLLKKR--EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 967 KRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD-SPRIK 1025
+KL +E + E+ + + +E +K Q + E E++ ++++ + S I+
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLE---TCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680
Query: 1026 ALEKELDDIKEAHQITVRNLEAEIDVLKH----QNAELDVKKNDKDDEDF----QSIEFQ 1077
L LD +++E E L + Q AE +K+ K+ E+ + Q
Sbjct: 681 NLHNVLDS---------KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 1078 VEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQ-----KDRRMMLSNQNSKGREEMSA 1132
VE K +L L+ E+ K R QDL E L+ KD ++ + + +
Sbjct: 732 VEDLEHKLQL--LSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ 789
Query: 1133 KRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHV--SEVLQE--------------- 1175
+ A +H S N G++ S+ + D S +LQ
Sbjct: 790 QPA----MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845
Query: 1176 NYRLKNELEGLISEKNELK---MKSEAVMNQF--ENSMR--RVKEDTAAH----IASLKA 1224
N L+ + E L+ K E++ MK+E + F E S R +++EDT+AH +L A
Sbjct: 846 NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA 905
Query: 1225 SHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQ--SQVNELQSKQESLVVSEV 1282
+E E L + VE +++ EL + E ++ Q S+ L+ K+ S ++S
Sbjct: 906 LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 1283 REEI--LQKEITKLLE---ELREAKENHTPEMKHFVGL----EKKIKQMEMRHAQREQEL 1333
+ EI L +E L E L + K N + + F EK I ++ ++ Q + L
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 1334 QQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSI-------LDVLREL--- 1383
Q ++T E ++ + + AQ KN +LE E S+ L+ L+E
Sbjct: 1026 LQRCEETGNAYE-----DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAK 1080
Query: 1384 HRQGVVVPVAFADEMN 1399
Q + +AFA+E N
Sbjct: 1081 EHQEFLTKLAFAEERN 1096
Score = 74.3 bits (181), Expect = 8e-13
Identities = 207/1101 (18%), Positives = 427/1101 (38%), Gaps = 135/1101 (12%)
Query: 3 NCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGT 62
+C +EL + E + L+ D ++DK++R+ + K W ++ F D +
Sbjct: 1850 SCDHQELLQRVET-SEGLNSDLEMHADKSSREDIGDNVAKVNDSW---KERFLD---VEN 1902
Query: 63 NVSYLKTKKTSQP------VMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHS 116
+S ++++K S ++E EK+ K + LE EL V +
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE-EELSVVTSERN 1961
Query: 117 SLGVGLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQ-ANAEL 175
L LDT+ ++ + K T +EL+S+ S + LH Q A AE+
Sbjct: 1962 QLRGELDTMSKKTTALDQLSEKMKEKT---------QELESHQS---ECLHCIQVAEAEV 2009
Query: 176 TDDEHENESKHEELAENYSD---------DFEDEYVGAPLTTKDEEMPSKENSKSEKISV 226
+ ++ +++E D E + LT + E + +K +++ V
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 227 PKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSS 286
+ E + + + ++ E L E+ + + T+ E+ +
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL----SSTQEEVHQLRRGIEKLR 2125
Query: 287 SDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNI--------S 338
+EA + HIA L + ++ E+++++D +++ Q +EEN + + +
Sbjct: 2126 VRIEADEKKQLHIAEKLKERER---ENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
Query: 339 TMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQD 398
+E+ +EE+ + +++ + + + K + K+ + L + L ++
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 399 SQHVNLFFDKNDENVI--LQ---KTTNESMENSCPQVTEVTATEEHVDKMYL--NILRKK 451
+ + + + + LQ K NE++ C + ATE+ +D + LR
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Query: 452 ITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVR 511
I + L D+K QL E A + K R + + L A
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362
Query: 512 SSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKP 571
+ ++ + + D++ ++ + T+ +++E +S ++I + +
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 572 AHKTESCLSTRKKSE---------------------NPTETDSCIQFQTDSLGYCGENKE 610
K + + ++KS N E + S C E ++
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNY 670
+LL + + EA++ + Q+ + + + +++LE K EE+ + + + QD
Sbjct: 2483 AQLL--QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI-----QDQE 2535
Query: 671 ILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ 730
L +KLS E + Q W E+ +++ E E +Q Q +N L +
Sbjct: 2536 QLVSKLSQVE--GEHQLWK-----------EQNLELRNLTVELEQKIQVLQSKNASLQDT 2582
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAE 790
++ LQ K E + S V + + K L + + + + +L E
Sbjct: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE 2642
Query: 791 LRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD-QAKDQIAY--VTGEKL--YEIK 845
E LLE+IK K + L ++ ++KK D KDQ+ E++ Y+++
Sbjct: 2643 KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR 2702
Query: 846 ILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSI 905
+ E K + L Q+ E Q +K L +E +KL++++ K E N S+
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREK--LTSKEECLSSQKLEIDLLKSSKEELNNSL 2760
Query: 906 RQKIRL-----KDKAADAKKIQDLERQVKEMEGILK---------RRYPNSLPALILAAS 951
+ ++ K K + K + L+++ + +G +K L +
Sbjct: 2761 KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
Query: 952 AAGD-----TVDKNTVEFMEKRIKKLEADLEGKDEDAKK------SLRTMEQQFQKMKIQ 1000
AA + TV V+ + IK+L+ LE K ++A + SL ++ +K K
Sbjct: 2821 AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK-- 2878
Query: 1001 YEQRLEQQEQLLACKLNQHDS 1021
+ LE Q L + ++ DS
Sbjct: 2879 --EMLETQVAHLCSQQSKQDS 2897
Score = 72.0 bits (175), Expect = 4e-12
Identities = 279/1465 (19%), Positives = 578/1465 (39%), Gaps = 258/1465 (17%)
Query: 11 EEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNVSYLKTK 70
E +Q ++ D+ NS A K+E+ T+ + + + LL N +K
Sbjct: 1104 ETVQQALRSEMTDNQNNSKSEAGGLKQEIM---TLKEEQNKMQKEVNDLLQENEQLMKVM 1160
Query: 71 KTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEE 130
KT +E E +S++ E SE N + +D ++
Sbjct: 1161 KTKHECQNLESEPIR---------------NSVKERE---SERNQCNFKPQMDLEVKEIS 1202
Query: 131 KEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHEN--ESKHEE 188
+ + A+L + ++ NKEL +S K ++ D E N + + +E
Sbjct: 1203 LDSYNAQLVQ-----LEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Query: 189 LA--ENYSDDFEDEYVGAPLTTKDEEMPSKENSKSE---KISVPKQEEEKTGMLANVVLL 243
++ ++ D E++Y+ P E+ + +N + + + + + ++
Sbjct: 1258 ISGLKDCEIDAEEKYISGP-----HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA 1312
Query: 244 DSLDSVAEVNLDEQDKITPKPRCLPEMTE--NEMT----GTGVSYGQSSSDVEA------ 291
+ + V E+N + IT + E+ + NE+ +G+ +G+ D+
Sbjct: 1313 EKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQ 1372
Query: 292 -----------LHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTM 340
L ++ + +L D++ Q + E S H ++++ + S M
Sbjct: 1373 PNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKM 1432
Query: 341 ESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERK---ETEFFSSLPLKMNPNILSQ 397
S+L T + +K + + +L+ + V E + E SL P
Sbjct: 1433 -SELQTYVDSLKAENL----VLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP----- 1482
Query: 398 DSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYL------NILRKK 451
DS ++ D + +L++T + S+ ++ V+A + VD+++ N+ RK+
Sbjct: 1483 DSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGA--VSANQCSVDEVFCSSLQEENLTRKE 1540
Query: 452 I-TVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQS-----G 505
+ + + + + + + YR L EE + K+ + LL + Q
Sbjct: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
Query: 506 LYASVRSSGYGKPSS-PLKMFSTL--EKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKL 562
Y S K +S L+M S L EKK +E + + + LS L
Sbjct: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLD-----LSSRSL 1655
Query: 563 IKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKL-LMFKRVQE 621
+ D + ESC +++ + TE + D C ++ ++ L L +++ E
Sbjct: 1656 LGIDTEDAIQGRNESCDISKEHTSETTERTP----KHDVHQICDKDAQQDLNLDIEKITE 1711
Query: 622 A-----EDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLN-----QDNYI 671
+ G Q+ + +K + + EL L ++ +D +
Sbjct: 1712 TGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1771
Query: 672 LQAKLSSFEETNKKQRWLHFGEAADPVTGE---KLKQIQKEIQEQETLLQGYQQENERLY 728
LQ ++ E +N+ R LH E D ++K++ ++ QE L + L
Sbjct: 1772 LQLRVK--ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
Query: 729 NQVKDLQEQNKKNEERMFK---ENQSLFSEVASLKE-----QMHKSRFLSQVVEDSEPTR 780
V +L+++N E++ ++Q L V + + +MH + + + D+
Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
Query: 781 N----QNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYV 836
N + F D+ EL + EK S+ + L+ D + ++ EK+ E+D Q V
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT--EKLCLEKDNENKQKVIV 1947
Query: 837 TGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKL 896
E+ E+ ++ Q L+ L ++ LD+ + +++E +E+E + E
Sbjct: 1948 CLEE--ELSVVTSERNQ----LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2001
Query: 897 KAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDT 956
IQ E +VKE +L+ L++ +
Sbjct: 2002 ------------------------IQVAEAEVKEKTELLQT----------LSSDVSELL 2027
Query: 957 VDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRT-MEQQFQKMKIQYEQRLEQQEQLLACK 1015
DK ++++++ LE KD A + +E Q ++ + E +++ E L A +
Sbjct: 2028 KDKT---HLQEKLQSLE-----KDSQALSLTKCELENQIAQLNKEKELLVKESESLQA-R 2078
Query: 1016 LNQHDSPRI---KALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQ 1072
L++ D ++ KALE L + K + + + + E+ L+ +L V+ + D++
Sbjct: 2079 LSESDYEKLNVSKALEAALVE-KGEFALRLSSTQEEVHQLRRGIEKLRVRI-EADEK--- 2133
Query: 1073 SIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSA 1132
K + + E+L ++RE L VE L+++ +M NQ + ++
Sbjct: 2134 -------------KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENS 2180
Query: 1133 KRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNE 1192
K + + + A S K+++ T E L + + E +G +SE ++
Sbjct: 2181 KAEVETLKTQIEEMARSL------KVFELDLVTLRSEKENLTKQIQ---EKQGQLSELDK 2231
Query: 1193 LKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRK 1252
L ++++ + E + ++KE++ + AVE +++ ELN
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEES--------------------KTAVEMLQNQLKELNEA 2271
Query: 1253 IAT----QEVLIRHFQS---QVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENH 1305
+A QE++ QS + E + S+ R E +K+ +L++L+E+ E+H
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES-EHH 2330
Query: 1306 TPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK-EVEKWKRLAQ---- 1360
+K + + +RE E+ + Q H +E E +K EVE K +
Sbjct: 2331 ADLLKG-----------RVENLERELEIAR-TNQEHAALEAENSKGEVETLKAKIEGMTQ 2378
Query: 1361 -LKNRELE--KFRTELDSILDVLRE 1382
L+ EL+ R+E +++ + L++
Sbjct: 2379 SLRGLELDVVTIRSEKENLTNELQK 2403
Score = 70.1 bits (170), Expect = 1e-11
Identities = 136/653 (20%), Positives = 276/653 (42%), Gaps = 116/653 (17%)
Query: 807 RLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYA 866
R Q Q LE +K+KKE+ Q + Q+ + L + K E K E + L++
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEA-ALQKQKQKVENEKTEGTNLKR------ 67
Query: 867 ENQELLDKDALRLREANEEIEKLKLEI-EKLKAESGNPSIRQKIRLKDKAADAKKIQDLE 925
ENQ RL E E +EK K +I +L+ + + ++ K K+I+ LE
Sbjct: 68 ENQ--------RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK----KQIEKLE 115
Query: 926 RQVKEMEGILKR---------------RYPNSL------PALILAASAAGDTVDKNTVEF 964
+++K + L+R P + P+ + S D +K E
Sbjct: 116 QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEV 175
Query: 965 MEKRIKKLEADLEGKDEDAKKSLRTMEQ---------QFQKMKIQYEQRLEQQEQLLACK 1015
E+ K+LEA++ K AKK+ +T+ Q + Q + + E+ L+
Sbjct: 176 EER--KRLEAEV--KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231
Query: 1016 -----LNQHDSPRIKALEKELDDIKEAHQITVRNLEAE----------IDVLKHQNAELD 1060
+ + S + E+E+ + QI R+ + +D LK QN EL
Sbjct: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 1061 VKKNDKD-------------DEDFQSIEFQVEQA------------HAKAKLVRLNEELA 1095
K N+ + FQ ++ Q+E+A + +LVR +
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 1096 AKKREIQDLSKTVERLQKDRRMMLSN-QNSKGREEMSAKRAKKDVLHSSKGNANSFPGTL 1154
+ L + +++L +D N ++++ E K +K+ SF TL
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ-TL 410
Query: 1155 DSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKED 1214
D + Q + +++ LQ+ + N L+ + + +K + E + +F+ + R ++
Sbjct: 411 DQECIQ----MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ- 465
Query: 1215 TAAHIASLKASH-QREIEKLLCQNAV-----ENSSSKVAELNRKIATQEVLIRHFQSQVN 1268
A + +K + +R +E++ +N + E + +V L ++ + + Q+
Sbjct: 466 -AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAE 524
Query: 1269 ELQSKQES--LVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKK----IKQM 1322
E+++K S ++ +++E+I Q+E + LE+L+ A + + L KK I+Q+
Sbjct: 525 EMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 1323 EMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDS 1375
+ ++ E+E + ++ ++ ++ +E+++ K L E EK T+++S
Sbjct: 585 NDKLSKTEKESKALLSALE--LKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
Score = 68.6 bits (166), Expect = 4e-11
Identities = 276/1460 (18%), Positives = 562/1460 (38%), Gaps = 199/1460 (13%)
Query: 3 NCSQEELDEEFEQFMKELSDD-SFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLG 61
+CSQ+ L + E +++L+D S + A S E+KKK+ ++ K++ L
Sbjct: 568 DCSQDLLKKR-EHHIEQLNDKLSKTEKESKALLSALELKKKEY-------EELKEEKTLF 619
Query: 62 TNVSYLKTKKTSQPVMEIEEESAE-KIQFLKSSGTSLLSTDSLETNE----LVVSELNHS 116
+ K +Q ME E+E+ + KI L++ L T ++++E + E++
Sbjct: 620 SCWKSENEKLLTQ--MESEKENLQSKINHLETC----LKTQQIKSHEYNERVRTLEMDRE 673
Query: 117 SLGVGLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFK-----ALHSNQA 171
+L V + L + + +K + Y L ++ + +D H K L ++Q
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQK-----LAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 172 NAELTDDEHENESKHEELAEN---YSD-DFEDEYVGAPLTTKDEEMPSKENSKSEKISVP 227
++ D EH+ + E+ + Y D E E + L +KD + + E+ + ++
Sbjct: 729 TGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Query: 228 KQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSS 287
+Q + S+ S E D+ +PK + + + + + S Q +S
Sbjct: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQ-SPKNSAILQNRVDSLEFSLESQKQMNS 847
Query: 288 DVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTV 347
D+ Q C E+ +I+ E++ + + H E S+ IS ++ D
Sbjct: 848 DL----QKQC--------EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 348 EELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFD 407
+ ++ +S + + + + ++ ETE LK + ++L + + L
Sbjct: 896 QNVVAET------LSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL-- 947
Query: 408 KNDENVILQKTTNESMEN-SCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKIN 466
E + L+K S+ + + ++ E+T + ++ ++ ++K+ + S S + I+
Sbjct: 948 --SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Query: 467 KTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSG-LYASVRSSGYGKPSSPLKMF 525
E E ++ YK+ + LL+R ++G Y + K+
Sbjct: 1006 ---------EREKSISELSDQYKQEKLI--LLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
Query: 526 STLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKS 585
L + TS + L + + +E L+ K A ++ L T +++
Sbjct: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLT-----KLAFAEERNQNLMLELETVQQA 1109
Query: 586 ENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATF----- 640
TD+ ++++ G E K K +E D + + L++ +K
Sbjct: 1110 LRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL 1169
Query: 641 -------SEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEE-TNKKQRWLHFG 692
S KE+E E K Q + E+ +++ D+Y A+L E K+ L
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY--NAQLVQLEAMLRNKELKLQES 1227
Query: 693 EAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSL 752
E +L+ I+ ++ E L QE L + D +E+ +
Sbjct: 1228 EKEKECLQHELQTIRGDL-ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
Query: 753 FSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDL-------LAELRMAQKEKDSLLEDI 805
SL+ M+K L ++ E + + + T+L + R +E LL ++
Sbjct: 1287 AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1346
Query: 806 KRLKQDKQALEVDF-------EKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQ-EISR 857
K L D L + E ++ +Q +A + YE L + Q +
Sbjct: 1347 KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE 1406
Query: 858 LQKR-LQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAA 916
LQ++ L +E++ L D+ + + ++ +L+ ++ LKAE ++ L++
Sbjct: 1407 LQEKFLSLQSEHKILHDQHC----QMSSKMSELQTYVDSLKAE----NLVLSTNLRNFQG 1458
Query: 917 DAKKIQDLERQVKEMEGILKRRYPNS------------------------LPALILAASA 952
D K L + + + P+S L L A SA
Sbjct: 1459 DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSA 1518
Query: 953 AGDTVDK-NTVEFMEKRIKKLEA---------DLEGKDEDAKKSLRTMEQQFQKMKIQYE 1002
+VD+ E+ + + E +LE E ++SL +E++ + I
Sbjct: 1519 NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN 1578
Query: 1003 QRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVK 1062
+ +++ EQLL+ + + D R + L + ++ +T+ +E+++ K Q +L +
Sbjct: 1579 KEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTL-EMESKLAAEKKQTEQLSL- 1636
Query: 1063 KNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSK-----TVERLQKDRRM 1117
+ + ++ Q +++ L E+ + E D+SK T ER K
Sbjct: 1637 -----ELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
Query: 1118 MLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQE-N 1176
+ +++++ + ++ + G S + D+ P SE + E +
Sbjct: 1692 QICDKDAQQDLNLDIEKITETGAVKPTGEC-SGEQSPDTNYEPPGEDKTQGSSECISELS 1750
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ 1236
+ N L + M N RVKE + ++ L R+
Sbjct: 1751 FSGPNAL---------VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD------- 1794
Query: 1237 NAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLE 1296
VE+ +++ EL+ K+ QEV +L +K E+ + E L+KE + L E
Sbjct: 1795 RKVESLLNEMKELDSKLHLQEV----------QLMTKIEACIELEKIVGELKKENSDLSE 1844
Query: 1297 ELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWK 1356
+L +H ++ E +EM HA + + + + K + WK
Sbjct: 1845 KLEYFSCDHQELLQRVETSEGLNSDLEM-HADK---------SSREDIGDNVAKVNDSWK 1894
Query: 1357 RLAQLKNRELEKFRTELDSI 1376
EL + R+E SI
Sbjct: 1895 ERFLDVENELSRIRSEKASI 1914
Score = 50.8 bits (120), Expect = 9e-06
Identities = 81/438 (18%), Positives = 179/438 (40%), Gaps = 35/438 (7%)
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE EG A + ++ +E Q K+K + +QR Q + L A Q +++ + E
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAAL--QKQKQKVENEKTEG 62
Query: 1032 DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLN 1091
++K +Q + E+ + + EL VK++ + ++ Q + + + +L R
Sbjct: 63 TNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 1092 EELAAKKREIQDLSKTVERLQKDRRMM-----------------LSNQNSKGREEMSAKR 1134
EL ++ Q ++ +++ L + +K EE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 1135 AKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS---EVLQENYRLKNELEGLISEKN 1191
A+ L + K + T++ + H + S S E + ++ + + +
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
Query: 1192 ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNR 1251
E + ++++ K D + +S +++L QN + +K+ EL
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQLKAQN--QELRNKINELEL 299
Query: 1252 KIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKE--ITKLLEELREAKENHTPEM 1309
++ E + + QVN+ Q Q L + + + E+++KE + K +EL +
Sbjct: 300 RLQGHE---KEMKGQVNKFQELQ--LQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
Query: 1310 KHFVGLEKKIKQM-EMRHAQRE--QELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNREL 1366
+ LE+K+K++ E QR+ + + ++Q + E E +E+ + +R Q ++E
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
Query: 1367 EKFRTELDSILDVLRELH 1384
+ + L L + +H
Sbjct: 415 IQMKARLTQELQQAKNMH 432
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 120 bits (301), Expect = 9e-27
Identities = 178/813 (21%), Positives = 342/813 (42%), Gaps = 122/813 (15%)
Query: 619 VQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSS 678
+ + E+K R A L E+I+ KE++ ++ E+K+Q E L L + +++ L+
Sbjct: 795 LNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV-EVKQQLELSLQTLEMELRTVKSNLNQ 853
Query: 679 -FEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ 737
+E N QR L + A + L + +E E + EN + + KDL +
Sbjct: 854 VVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHK 913
Query: 738 NKKNEERMFK--------ENQSLFSE---VASLKEQMHKSRFLSQVVEDSEPTRNQNFTD 786
N +E + +NQ+ E LK K+ L + ++ +E T Q +
Sbjct: 914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 973
Query: 787 LLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA-KDQIAYVTGEKLYEIK 845
L + E L ++ KQ K+ LE + E A D+ T ++ E++
Sbjct: 974 YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKR--ELE 1031
Query: 846 ILEETHKQEISRLQKRLQW----YAENQELLDKDALRLREANEEIEKLKLEIEKLKAESG 901
+ + + E SRLQ ++ + +N E+L + +L + ++ L++E +
Sbjct: 1032 LAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ---QLFKTESKLNSLEIEFHHTR---- 1084
Query: 902 NPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNT 961
++R+K ++ K + + Q+KEME ++Y N + K
Sbjct: 1085 -DALREKTLGLERV--QKDLSQTQCQMKEME----QKYQNE-------QVKVNKYIGKQ- 1129
Query: 962 VEFMEKRIKKLEA----------DLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQL 1011
E +E+R+ +L++ D K ++ +K++ ++ QF + + + E+Q L
Sbjct: 1130 -ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL 1188
Query: 1012 LACKLNQ--HDSPRIKALEKELDDIKEAHQITVRNLEAEI-DVLKHQN---AELDVKKND 1065
L + + + +K + + ++ K ++ VR L+ E+ D LK Q+ A L+V
Sbjct: 1189 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1248
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSK 1125
+ I + E K KL ++ +L + + + E++Q D + L N+K
Sbjct: 1249 R-------INLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQ-DHKQKLEKDNAK 1300
Query: 1126 GREEMSAKRAKKDVLHSSKGNANSFPGTLD--SKLYQPHTFTDSHVSEVLQENYRLKNEL 1183
+ + + K + L + NAN + KL + + ++ + +++N L+ E+
Sbjct: 1301 LKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREI 1360
Query: 1184 EGLIS------------EKNELKMKSEAVMNQFE-----NSMRRVKEDTAAHIAS----- 1221
G + E E + +QFE N ++ +D A + +
Sbjct: 1361 TGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1420
Query: 1222 --LKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIR-HFQSQVNEL----QSKQ 1274
L +Q E+LL V+ K+ + +K+ + + +R H + + EL Q KQ
Sbjct: 1421 LHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQ 1480
Query: 1275 ESLVVSEVREEILQ--KEITKLL-------EELREAKENHTPEMKHFVGLEKKIKQMEMR 1325
E + R+EI + KE+ L E L + +EN+ MK QME+R
Sbjct: 1481 E--IEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMK---------SQMELR 1529
Query: 1326 HAQREQELQQIIQQTHQVVETEQNKEVEKWKRL 1358
E EL +I +T Q E E+EK+K+L
Sbjct: 1530 IKDLESELSKI--KTSQ--EDFNKTELEKYKQL 1558
Score = 60.5 bits (145), Expect = 1e-08
Identities = 157/797 (19%), Positives = 310/797 (38%), Gaps = 95/797 (11%)
Query: 639 TFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPV 698
T E +LE EE +QE+E + NQ + K E +H G D
Sbjct: 518 TSKAAEHDLEVASEE---EQEREGSENNQPQVEEERKKHRNNEMEVSAN-IHDGATDDAE 573
Query: 699 TGEKLKQIQKEIQEQETLLQGYQQENERLYN------QVKDLQEQNKKNEERMFKENQSL 752
+ + ++ + ET Q + ++ + Y Q+K+++ K+ N +
Sbjct: 574 DDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPV 633
Query: 753 FSEVASLKE---QMHKSRFLSQVVEDS-EPTRNQNFTDLLAELRMAQKEKDSLLEDIKRL 808
F + + L Q+ LS++ ED PT+ + + K + ++D+ L
Sbjct: 634 FGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTS------NEKNKVKNQIQSMDDVDDL 687
Query: 809 KQDKQALEVDFE------------------KMKKERDQAKDQIAYVTGEKLYEIKILEET 850
Q + D E + K K Q A ++ E+L E+K
Sbjct: 688 TQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELK----- 742
Query: 851 HKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIR 910
K L +++ + +L ++ +E ++E K+E E+ +++ +
Sbjct: 743 -KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
Query: 911 LKDKAADAKKIQDLERQVKEM---EGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEK 967
++ +KI++ R+ +E E +K++ SL L + TV N + +++
Sbjct: 802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELR----TVKSNLNQVVQE 857
Query: 968 RIKKLEADLEGKDEDAKKSLRTMEQQFQKMK--IQYEQRLEQQEQLLACKLNQHDSPRIK 1025
R DA++ L + EQ + ++ I +Q+E +A K ++
Sbjct: 858 R------------NDAQRQL-SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSH 904
Query: 1026 ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAEL------DVKKNDKDDEDFQSIEFQVE 1079
EK+L Q + L EID +K+QN E D+K + +ED Q Q E
Sbjct: 905 EEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE 964
Query: 1080 QAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV 1139
+ + + + N L+ E L+ +E +K + L + ++A +D
Sbjct: 965 ETLTQT-ISQYNGRLSVLTAENAMLNSKLEN-EKQSKERLEAEVESYHSRLAAAIHDRDQ 1022
Query: 1140 LHSSKGNAN-SFPGTLD--SKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMK 1196
+SK +F D S+L F VS + N L +L S+ N L+++
Sbjct: 1023 SETSKRELELAFQRARDECSRLQDKMNF---DVSNLKDNNEILSQQLFKTESKLNSLEIE 1079
Query: 1197 ---SEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKI 1253
+ + + + RV++D + +K Q+ + + N V E ++
Sbjct: 1080 FHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQL 1139
Query: 1254 ATQEVLIRHFQSQVNELQSKQESLVVSEVREEI------LQKEITKLLEELREAKENHTP 1307
++ +L+R + +E V++ ++++ LQ E K L E +
Sbjct: 1140 QSENMLLRQQLDDAHNKADNKEKTVIN-IQDQFHAIVQKLQAESEKQSLLLEERNKELIS 1198
Query: 1308 EMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKE--VEKWKRLAQLKNRE 1365
E H L+++ Q E A+RE ++Q+ Q+ ++ + E +E R E
Sbjct: 1199 ECNH---LKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDE 1255
Query: 1366 LEKFRTELDSILDVLRE 1382
+ + +L I + L+E
Sbjct: 1256 TQDLKKKLGQIRNQLQE 1272
Score = 50.8 bits (120), Expect = 9e-06
Identities = 95/526 (18%), Positives = 217/526 (41%), Gaps = 73/526 (13%)
Query: 529 EKKTSEDIIKSKNLRSISTSNQPRKKEI-LSGTKLIKPAALDKPAHKTESCLSTRKKSEN 587
E + +++ +N IS N ++++ K + + + + L + SE
Sbjct: 1181 ESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA 1240
Query: 588 PTETDSCIQFQTDSLGYCGENKEKKLLMFK-RVQEAEDKWRGAQALIEQIKATFSEKEKE 646
E S + + ++ +KKL + ++QEA+D+ A E+++ + +++
Sbjct: 1241 SLEVTSRYRINLEDET---QDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQ----DHKQK 1293
Query: 647 LENKLEELKKQQEKELFKLNQ-DNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQ 705
LE +LK +K++ K+ + +L A LS E+ E+LK+
Sbjct: 1294 LEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEK-------------------EQLKK 1334
Query: 706 IQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQM-- 763
+ + Q E L ++N L ++ + K +++ + FS LK
Sbjct: 1335 LMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFE 1394
Query: 764 ---------HKSRFLSQVVEDSE------PTRNQNFTDLLAELRMAQKEKDSLLEDIKRL 808
HK L+ +E + T+NQ + L ++ QK+ + L ++ K+L
Sbjct: 1395 MDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL 1454
Query: 809 KQDKQALE-------VDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKR 861
+Q+ L V+ ++K+ + + +++ EKL E+ + Q + Q+
Sbjct: 1455 EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF----LQAQAASQEN 1510
Query: 862 LQWYAENQ--ELLDKDALRLREANEEIEKLKL---EIEKLKAESGNPSIRQKIRLKDKAA 916
L+ + EN + + LR+++ E+ K+K + K + E ++++++ K+
Sbjct: 1511 LEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVR-KSL 1569
Query: 917 DAKKIQDLERQVKEMEGILKRR------YPNSLPALILAASAAGDTVDKNTVEFMEKRIK 970
+K + ER + +L + + ++ G+ N+++ K I
Sbjct: 1570 SSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNL--NNSLDLNRKLIP 1627
Query: 971 KLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKL 1016
+ +L + + S +ME KM+ + E+ + ++ + A +L
Sbjct: 1628 R--ENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAEL 1671
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 120 bits (300), Expect = 1e-26
Identities = 249/1352 (18%), Positives = 555/1352 (41%), Gaps = 205/1352 (15%)
Query: 58 GLLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSS 117
G +G+ S L + T +++ ES+ + SL S D L + V + + S
Sbjct: 11 GRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDS 70
Query: 118 LGVGLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAE--L 175
G L + + + + L +S+ + E + ++ L +A + +
Sbjct: 71 GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
Query: 176 TDDEHENESKHEELAENYSDDFED-------EYVGAPLTTKDEEMPSKENSKSEKISVPK 228
TD E +S ++L E +++F E A L T+ ++ SK + E+ S+ +
Sbjct: 131 TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD---EERSLRE 187
Query: 229 QEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSD 288
E+K L + L+ A V D + ++ +P D
Sbjct: 188 AAEQKVTRLT-----EELNKEATVIQDLKTELLQRP--------------------GIED 222
Query: 289 VEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVE 348
V L + + + + ++ + E +K K + + IS + S+L
Sbjct: 223 VAVLKKELVQVQTLMDNMTLERERES--EKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 349 ELMKPIRIDSFGISGFDLQPVSSE--KVAERKETEFFSSLPLKMNPNILSQDSQHVNLFF 406
+ + +LQ + S ++ ++ +T + N+L ++ + L
Sbjct: 281 Q--------EVAVYVQELQKLKSSVNELTQKNQT---------LTENLLKKEQDYTKLEE 323
Query: 407 DKNDENVILQ--KTTNESMENSCPQV-TEVTATEEHVDKMYLNILRKKITVNSSSLSQDD 463
N+E+V + + T + C Q+ + ++A+E + ++++ LS+
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE------------LSEKG 371
Query: 464 KINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLK 523
+ + + +LS E E + +K+ + + K Q GL + K
Sbjct: 372 EATQKLKEELS-EVETKYQHLKAEFKQLQQQR---EEKEQHGLQLQSEINQLHS-----K 422
Query: 524 MFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKL----IKPAALDKPAHKTESCL 579
+ T E++ E + K R +S+ K++ ++ +L ++ +K + TE
Sbjct: 423 LLET-ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481
Query: 580 STRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKAT 639
K + E + Q T L + E+ L +++ + + K + +AL+++ K
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL---RQIGDKDQKIQNLEALLQKSKEN 538
Query: 640 FSEKEKELENKLEELKKQQEKE--LFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADP 697
S EKE E+ +++ + + L +L + N+ LQ +++ E K Q H
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH------- 591
Query: 698 VTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFK-------ENQ 750
+ + + ++QEQ+ L+ Q L V +L Q +++E++ + + +
Sbjct: 592 --KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 751 SLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQ 810
L S A+ Q + +++ + Q + +L + E +L+
Sbjct: 650 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 811 DKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQE 870
+ + + ++++ ++ + QI + + L E+K +E Q + LQ++ Q + +
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSL-EVKASKE---QALQDLQQQRQLNTDLEL 765
Query: 871 LLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKK--IQDLERQV 928
+ + +L E + +L+++K K+E+ SI+QK+ +++ K + L ++
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQK-KSEALE-SIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 929 KEMEGILKRRYPNSLP----------ALILAASAAGDTVDKNTVEFMEKRIKKLEADLEG 978
K L R ++ AL+ S D + K + +K +++ E
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK-----VSDSLKNSKSEFEK 878
Query: 979 KDEDAKKSLRTMEQQFQKMK----IQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDI 1034
+++ K ++ +E+ +++K +Q E L++Q++L K+LEKE
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK------------KSLEKE---- 922
Query: 1035 KEA-HQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEE 1093
KEA HQ+ + + +++ QN +K+N+K+++ Q +++Q+ + K ++
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNT---LKQNEKEEQQLQGNINELKQSSEQKK-----KQ 974
Query: 1094 LAAKKREIQDLSKTVERLQK-DRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPG 1152
+ A + E++ + LQK + L Q ++ +E++A++ K VL ++ +
Sbjct: 975 IEALQGELK-----IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 1153 TLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVK 1212
L S Y + + ++ +L E LIS +N++ +++ + + + + ++
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ-ELKTAKATLE 1088
Query: 1213 EDTAAHIASL----KASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVN 1268
+D+A L KA + EK L + + N SK+AE +
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE------------------IE 1130
Query: 1269 ELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQ 1328
E++ +QE KEITKL EEL+ K E+ + ++ + Q ++
Sbjct: 1131 EIKCRQE-------------KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG 1177
Query: 1329 REQELQQIIQQ---THQVVETEQNKEVEKWKR 1357
+ L+ ++Q Q+++ + KE E+ K+
Sbjct: 1178 KADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209
Score = 119 bits (297), Expect = 3e-26
Identities = 243/1158 (20%), Positives = 480/1158 (41%), Gaps = 162/1158 (13%)
Query: 288 DVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTV 347
DV L Q + SL +E K S ++ +G Q+ + ++ ++L ++
Sbjct: 84 DVTLLRQEVQDLQASLKEE---KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL 140
Query: 348 EELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQH--VNLF 405
E+ ++ + ++F I ++ + +K A+ TE L + ++ L
Sbjct: 141 EQQLEEAQTENFNIK--QMKDLFEQKAAQLA-TEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 406 FDKNDENVILQKTTNESMENSCPQVTEVTATEEHV-------DKMYLNILRK--KITVNS 456
+ N E ++Q E ++ P + +V ++ + D M L R+ K+
Sbjct: 198 EELNKEATVIQDLKTELLQR--PGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
Query: 457 SSLSQDDKINKTYRSQLSSE-----EEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVR 511
L ++ SQL SE +E AV +++ +K +S+ L +K Q+ ++
Sbjct: 256 KKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL--QKLKSSVNELTQKNQTLTENLLK 313
Query: 512 SSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKP 571
+ ++ LE+K +E+ + KN+++ +++ S + +
Sbjct: 314 KE---------QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
Query: 572 AHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQA 631
+E +T+K E +E ++ Q + +E+K E Q+
Sbjct: 365 VELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK----------EQHGLQLQS 414
Query: 632 LIEQIKATFSEKEKEL---ENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW 688
I Q+ + E E++L +L+E ++ ++L Q LQ KLS EE K++
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE-QLKEKV 473
Query: 689 LHFGEAADPVTGEKLKQIQKEIQEQETL--LQGYQQENERLYNQVKD----------LQE 736
+ E + K + +++ +Q T L+ Q + E++ Q+ D L +
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 737 QNKKNEERMFKENQSLFS-------EVASLKEQMHKSRFLS-QVVEDSEPTRNQNFTDLL 788
++K+N + KE + L++ E A L + K+ L QV + +E +NQ+ +
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 789 AELRM---AQKEKDSLLEDIKRLKQDKQ-ALEVDFEKMKKERDQAKDQIAYVTGEKLYEI 844
A+ + Q++K L R QD+ +LE ++ + +++K++++ + +I
Sbjct: 594 AQENLHDQVQEQKAHL-----RAAQDRVLSLETSVNELNSQLNESKEKVSQL------DI 642
Query: 845 KILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPS 904
+I +T + K Q A+ Q LD L++ +E+ K+ +++++ A+ +
Sbjct: 643 QIKAKTELLLSAEAAKTAQ-RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
Query: 905 IRQKIRLKDKAADAK-KIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVE 963
+L+ + K K LE++ +E+EG +K+ +SL A D + +
Sbjct: 702 -EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 964 F-MEKRIKKLEADLEGKDE-------DAKKSLRTMEQQFQKMKIQYEQR--LEQQEQLLA 1013
+E R +L LE + E D +K +E QK+ Q E++ L+Q + L+
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 1014 CKLN-QHD--SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDED 1070
+ QH+ + RI+ EL +K + + L D L + L KN K
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL---KNSKS--- 874
Query: 1071 FQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEM 1130
EF+ E KA ++ DL KT + L+ ++ + N + +E
Sbjct: 875 ----EFEKENQKGKAAIL--------------DLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 1131 SAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEK 1190
+ +K+ H K NS + +L Q L++N + + +L+G I
Sbjct: 917 KSLEKEKEASHQLKLELNS----MQEQLIQ--------AQNTLKQNEKEEQQLQGNI--- 961
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
NELK SE Q E +K IA L+ + E+E L Q + + AE
Sbjct: 962 NELKQSSEQKKKQIEALQGELK------IAVLQKT---ELENKLQQQLTQAAQELAAE-K 1011
Query: 1251 RKIATQEVLIRHFQSQVNELQS----KQESLVVSEVREEILQKEITKLLEELREAKENHT 1306
KI+ + Q +LQS ++ L+ + + ++++++ E+L +
Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071
Query: 1307 PEMKHFVGLEKKIKQMEMRHAQREQELQ------QIIQQTHQVVETEQNKEVEKWKRLAQ 1360
+ K L+ +E A++EQ+LQ Q IQ+ + E E E K + +
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Query: 1361 LK---NRELEKFRTELDS 1375
+K +E+ K EL S
Sbjct: 1132 IKCRQEKEITKLNEELKS 1149
Score = 97.4 bits (241), Expect = 8e-20
Identities = 192/892 (21%), Positives = 377/892 (42%), Gaps = 145/892 (16%)
Query: 539 SKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLST---RKKSENPTETDSCI 595
++ L +T Q K E+L + A L K + ++ + ++ E+ D C
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
Query: 596 QFQTDSLGYCGENKEKKLLMFKRVQEAE------DKWRGAQALIEQIKATFSE---KEKE 646
+ Q+ + + + K QE K + + + Q T +E K+++
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 647 LENKLEEL-------KKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVT 699
KLEE KK + L + + D LQ++LS+ E + LH
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS------LHRIHVELSEK 370
Query: 700 GEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASL 759
GE +++++E+ E ET Q + E ++L Q ++ ++ + + + + + L L
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
Query: 760 KEQMHKSRFLSQVVEDSEPTRNQNFTDLLAEL-RMAQKEKDSL---------LEDIKRLK 809
E + + Q+ + + Q DL +L R+ ++ K+ + L+ K+
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 810 QDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILE---ETHKQEISRLQK-RLQWY 865
Q++QAL+ +E +Q+ G+K +I+ LE + K+ IS L+K R Y
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY 550
Query: 866 AENQELLDKDAL--RLREANEEIEKLKLEI-EKLKAESGNPSIRQKIRLKDKAADAK--- 919
A+ Q + A+ +L+E N +++ ++ EKLK +S + Q+ L D+ + K
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE-NLHDQVQEQKAHL 609
Query: 920 -----KIQDLERQVKEMEGILKRRYPN---------SLPALILAASAAGDTVDKNTVEFM 965
++ LE V E+ L + L+L+A AA T +
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA------KTAQ-- 661
Query: 966 EKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK 1025
ADL+ + A+ +L+ +Q+ K+ Q +Q + KL Q
Sbjct: 662 -------RADLQNHLDTAQNALQDKQQELNKITTQLDQ--------VTAKL-QDKQEHCS 705
Query: 1026 ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKA 1085
LE L + KE + +LE + + L+ Q +KK + D + ++ + Q Q +
Sbjct: 706 QLESHLKEYKEKYL----SLEQKTEELEGQ-----IKKLEADSLEVKASKEQALQDLQQQ 756
Query: 1086 KLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKG 1145
+ +LN +L + E+ + + + R+ L + S+ E + K K++
Sbjct: 757 R--QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK-SEALESIKQKLTKQEE------ 807
Query: 1146 NANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE 1205
+ ++ + T S +++ E L N ++ ++E ++KM+ EA+M +
Sbjct: 808 ---------EKQILKQDFETLSQETKIQHEE--LNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 1206 NSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQS 1265
VK+ + SLK S + E EK EN K A L+ + +E ++H
Sbjct: 857 T----VKDKLSKVSDSLKNS-KSEFEK-------ENQKGKAAILDLEKTCKE--LKH--- 899
Query: 1266 QVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMR 1325
+LQ + E+ + QKE+ K LE+ +EA E+ +++++ Q +
Sbjct: 900 ---QLQVQMENTLKE-------QKELKKSLEKEKEASHQLKLELN---SMQEQLIQAQNT 946
Query: 1326 HAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSIL 1377
Q E+E QQ+ +++ ++ + K+ + +LK L+K TEL++ L
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK--TELENKL 996
Score = 95.9 bits (237), Expect = 2e-19
Identities = 181/910 (19%), Positives = 397/910 (43%), Gaps = 110/910 (12%)
Query: 511 RSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDK 570
+ S ++P+ + +SE I + ++S+ +++ E+ + + A D
Sbjct: 16 QGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSAD-----ELFKHYEAVHDAGNDS 70
Query: 571 PAHKTESCLSTRKKSENPTETD-SCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGA 629
H ES L+ ++ + +Q + E +K+L ++ +Q+ E K G
Sbjct: 71 -GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDG- 128
Query: 630 QALIEQIKATFSEKEKELEN-KLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW 688
L+ A E++LE + E +Q K+LF+ Q L +++ + ++R
Sbjct: 129 --LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFE--QKAAQLATEIADIKSKYDEERS 184
Query: 689 LHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEE-RMFK 747
L EAA+ +K+ ++ +E+ ++ T++Q + E + ++D+ K+ + +
Sbjct: 185 LR--EAAE----QKVTRLTEELNKEATVIQDLKTELLQRPG-IEDVAVLKKELVQVQTLM 237
Query: 748 ENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLA---ELRMAQKEKDSLLED 804
+N +L E S K + + SQ SE T +Q ++L E+ + +E L
Sbjct: 238 DNMTLERERESEKLKDECKKLQSQYAS-SEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 805 IKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEIS--RLQKRL 862
+ L Q Q L + +KKE+D K + + E + + I H++++ +LQ RL
Sbjct: 297 VNELTQKNQTLTENL--LKKEQDYTKLEEKH-NEESVSKKNIQATLHQKDLDCQQLQSRL 353
Query: 863 QWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQ 922
+ ++ L + + L E E +KLK E+ +++ + + A+ K++Q
Sbjct: 354 ---SASETSLHRIHVELSEKGEATQKLKEELSEVET-----------KYQHLKAEFKQLQ 399
Query: 923 DLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDED 982
+R+ KE G+ + N L + +L E+++ + L+ + +
Sbjct: 400 Q-QREEKEQHGLQLQSEINQLHSKLLET---------------ERQLGEAHGRLKEQRQL 443
Query: 983 AKKSLRTMEQQFQKMKIQYEQRLEQQ--EQLLACKLNQHDSPRIKALEKELDDIKEAHQI 1040
+ + L EQQ ++++ RLE+Q E++ QH + K +E ++++
Sbjct: 444 SSEKLMDKEQQVADLQLKLS-RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
Query: 1041 TVRNLEAEIDVLKHQNAELDVKKND------KDDEDFQSIEFQVEQAHAK--------AK 1086
+R + +++ + Q + D K + K E+ +E + E +AK A
Sbjct: 503 KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 1087 LVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGN 1146
L +L E+ + ++ L++ ++ + + N + + +E+ + RA +D + S + +
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 1147 ANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFEN 1206
N L+S+L + +V Q + ++K + E L+S + + + N +
Sbjct: 623 VNE----LNSQLNESK-------EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671
Query: 1207 SMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSS---SKVAELNRKIATQEVLIRHF 1263
+ + +D + + + KL Q+ E+ S S + E K + E
Sbjct: 672 AQNAL-QDKQQELNKITTQLDQVTAKL--QDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 1264 QSQVNELQSKQESLVVSEVREEILQ-----KEITKLLEELREAKENHTPEMKHFV----- 1313
+ Q+ +L++ +SL V +E+ LQ +++ LE LR + + EM+ +
Sbjct: 729 EGQIKKLEA--DSLEVKASKEQALQDLQQQRQLNTDLE-LRATELSKQLEMEKEIVSSTR 785
Query: 1314 -GLEKKIKQMEM--RHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFR 1370
L+KK + +E + +++E +QI++Q + + E + E+ Q EL+K +
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 1371 TELDSILDVL 1380
E ++++ L
Sbjct: 846 MEKEALMTEL 855
Score = 90.5 bits (223), Expect = 1e-17
Identities = 234/1214 (19%), Positives = 472/1214 (38%), Gaps = 157/1214 (12%)
Query: 85 EKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEEKEQFFARL-EKGLT 143
+++Q LKSS L + T L+ E +++ L + EE K+ A L +K L
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHN--EESVSKKNIQATLHQKDLD 345
Query: 144 SSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEELAENYSD----DFED 199
SRL+ S H + +A +L ++ E E+K++ L + E
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK 405
Query: 200 EYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDK 259
E G L ++ ++ SK ++ ++ L++ L+D VA++ L
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL----- 460
Query: 260 ITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDI 319
K L E + ++T + E HQ D+ KQ+ +
Sbjct: 461 ---KLSRLEEQLKEKVTNS----------TELQHQL---------DKTKQQHQEQQALQQ 498
Query: 320 KSSVKGHPQEN--EENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAER 377
++ K +N E+ + I + + +E L++ + ++ + + + + ++ A
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK-ENISLLEKEREDLYAKIQAGE 557
Query: 378 KETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATE 437
ET + L K N + Q +Q ++++ + Q+ ++ ++ Q + A +
Sbjct: 558 GETAVLNQLQEK-NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE---QKAHLRAAQ 613
Query: 438 EHVDKMY--LNILRKKITVNSSSLSQDDKINKTYRSQLSSEE-----------------E 478
+ V + +N L ++ + +SQ D K L S E +
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
Query: 479 GAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIK 538
A+ KQ K + + K Q + + K + + +LE+KT E +
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK--EKYLSLEQKTEELEGQ 731
Query: 539 SKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQ 598
K L + S + K++ L + + D TE + E + T +Q +
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 599 TDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQ 658
+++L E+ ++KL ++ E+K +++Q T S++ K +L +
Sbjct: 792 SEAL----ESIKQKL-----TKQEEEK-----QILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 659 EKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQ 718
EL K+ + L +LS+ ++ K + LK + E
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSK-------------VSDSLKNSKSE--------- 875
Query: 719 GYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEP 778
+++EN++ + DL++ K+ + ++ + ++ E LK+ + K + S ++
Sbjct: 876 -FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 779 TRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA---KDQIAY 835
+ + L+ +KE+ L +I LKQ + + E ++ E A K ++
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 836 VTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKD-------ALRLREANEEI-E 887
++L + K++IS LQ + E + L D L R+ + + E
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 888 KLKLEIEKLKAESGNPSIRQKIRLKDKAA-------DAKKIQDLERQVKEMEGILKRRYP 940
KL L E L + + K+ + K A AKK Q L+ + K ++ I K +
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK-- 1112
Query: 941 NSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQ 1000
SL L + + EK I KL +L+ ++ K + ++ Q +
Sbjct: 1113 -SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ---LL 1168
Query: 1001 YEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELD 1060
+Q+LE Q + + K A+E+E K QI ++ E + LK + E +
Sbjct: 1169 IQQKLELQGKADSLK---------AAVEQE----KRNQQILKDQVKKEEEELKKEFIEKE 1215
Query: 1061 VKKNDK-DDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK---DRR 1116
K + + +++ + + +A ++ LNE L K+E Q + V L+K D R
Sbjct: 1216 AKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 1117 MMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
++ + + +RA + +G L +K+ + D+ + V +
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEK----LQTKVLELQRKLDNTTAAVQE-- 1329
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC- 1235
L E + L + + + A N+ +N M K +++ H R+ + C
Sbjct: 1330 --LGRENQSLQIKHTQALNRKWAEDNEVQNCMACGK----GFSVTVRRHHCRQCGNIFCA 1383
Query: 1236 ----QNAVENSSSK 1245
+NA+ SS K
Sbjct: 1384 ECSAKNALTPSSKK 1397
Score = 61.2 bits (147), Expect = 7e-09
Identities = 92/422 (21%), Positives = 183/422 (43%), Gaps = 67/422 (15%)
Query: 981 EDAKKSLRTMEQQFQKMKIQYE--QRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAH 1038
+D + SL+ + +++K + E Q L+QQE L S +++LE++L++ + +
Sbjct: 93 QDLQASLKEEKWYSEELKKELEKYQGLQQQEAK-PDGLVTDSSAELQSLEQQLEEAQTEN 151
Query: 1039 QITVRNLEAEIDVLKHQNAELDVKKND---KDDEDFQSIEFQVEQAHAKAKLVRLNEELA 1095
N++ D+ + + A+L + D K DE+ +S+ EQ K+ RL EEL
Sbjct: 152 F----NIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQ-----KVTRLTEELN 201
Query: 1096 AKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLD 1155
+ IQDL E LQ+ G E+++ L
Sbjct: 202 KEATVIQDLK--TELLQRP-----------GIEDVAV---------------------LK 227
Query: 1156 SKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDT 1215
+L Q T D+ E +E+ +LK+E + L S+ SEA ++Q + + + ++
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQY----ASSEATISQLRSELAKGPQEV 283
Query: 1216 AAHIASLK-----ASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE- 1269
A ++ L+ + + + L +N ++ +L K + V ++ Q+ +++
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD-YTKLEEKHNEESVSKKNIQATLHQK 342
Query: 1270 ---LQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRH 1326
Q Q L SE + E+++ E ++ KE + + L+ + KQ++ +
Sbjct: 343 DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402
Query: 1327 AQREQ---ELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLREL 1383
++EQ +LQ I Q H + + + E RL + + EK + + D+ +L
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 1384 HR 1385
R
Sbjct: 463 SR 464
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 119 bits (299), Expect = 2e-26
Identities = 290/1430 (20%), Positives = 566/1430 (39%), Gaps = 241/1430 (16%)
Query: 79 IEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEEKEQ--FFA 136
IE+ +K + + + T ++ E+ + + L EQ+EK + F
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 137 RLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEELAENYSDD 196
LEK L+++ ++L + K + ++ + + K E + +
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV--DVMKK 472
Query: 197 FEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDE 256
+E + ++E+ KE ++K+ ++E ++ V L S +++ ++
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ---MKVALEKSQSEYLKISQEK 529
Query: 257 QDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTV 316
+ + + L + +T + + E + SL ++ ++ N
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL----EKSLQENKN 585
Query: 317 EDIKSSVKGHPQENEENSKNISTM----ESDLPTVEELMKPIRIDSFGISGFDLQPVSSE 372
+ +V ++N+ N K I+ M +++L +++ + + + Q E
Sbjct: 586 QSKDLAVHLEAEKNKHN-KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ-TEME 643
Query: 373 KVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVT- 431
K+ E+ E E + L K I+ Q H+ +K E + +++T ES+ + +V
Sbjct: 644 KLREKCEQEKETLLKDK---EIIFQ--AHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 432 -------EVTATEEHVDKMYLNILRK-------------------KITVNSSSLSQDDKI 465
E++ ++ DKM + K ++++ + + D+I
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI 758
Query: 466 NKTY-----RSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSS 520
N+ R + E + V + K RS L + + ++ S +S+ + + +
Sbjct: 759 NQLELLLKERDKHLKEHQAHVENLEADIK--RSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 521 PLKMFSTLEKKT----SEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALD--KPAHK 574
+ + L++K +E I+ +K + + + +KK++ + K D + K
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEV----EAQKKDVCTELDAHKIQVQDLMQQLEK 872
Query: 575 TESCLSTRKKS-----ENPTETDSCIQFQTDSLGYCGEN----------KEKKLLMFKRV 619
S + + KS E+ E + Q QT + EN KE ++L K
Sbjct: 873 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 932
Query: 620 ----------QEAEDKWRGAQALIEQIKATFSEKEKELENKL----EELKKQQEKELFKL 665
+E E K++ + +E++K E ++ L+ KL +LKK+ E +L
Sbjct: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL 992
Query: 666 NQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQE-- 723
+Q AK+ + N +D V+ +L+ QKE + E+L + +++E
Sbjct: 993 SQKEKQFNAKMLEMAQANS-------AGISDAVS--RLETNQKE--QIESLTEVHRRELN 1041
Query: 724 ------NERLYNQVKDLQE------QNKKNEERMFKENQSLFSEVASLKEQMHKS-RFLS 770
++L Q ++LQE Q K+ E K+ LF KE+M+K +L
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG---CEKEEMNKEITWLK 1098
Query: 771 QVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAK 830
+ + T N+ L +L+ +SL +D +LK + LEVD K KE +
Sbjct: 1099 EEGVKQDTTLNE----LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ 1154
Query: 831 DQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLK 890
+Q L E+K+L E K+++S L +L+ E + L ++N+ +E
Sbjct: 1155 EQ--------LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH---EKSNKSLEDKS 1203
Query: 891 LEIEKLKAESGNPSIRQKIRLKDKAA--DAKKIQDLERQVKEMEGILKR------RYPNS 942
LE +KL E +I+ I K A +AK + + + IL R R
Sbjct: 1204 LEFKKLSEEL---AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV 1260
Query: 943 LPALILAASAAGD--------TVDKNTV-----------EFMEKRIKKLEADLEGKDEDA 983
AL++ + T ++NT+ E E +IK ++AD+E
Sbjct: 1261 KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE------ 1314
Query: 984 KKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVR 1043
SL T ++ QK +Q ++E + +L + S I A+ +++KE
Sbjct: 1315 --SLVTEKEALQKEGGNQQQAASEKESCIT-QLKKELSENINAVTLMKEELKEK------ 1365
Query: 1044 NLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQD 1103
+ EI L Q +L+V+ + SI ++A + + +EE ++QD
Sbjct: 1366 --KVEISSLSKQLTDLNVQLQN-------SISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 1104 LSKTVERLQKDRRMMLSNQN--SKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSK-LYQ 1160
LS V+ L K++ L + S E K + H + L SK Y+
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 1161 PHTFTDSHVSEVLQENYR---LKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAA 1217
+ E+ Q+N R LK E+E +K++++ K + + ++ R+ E
Sbjct: 1477 KDEQINLLKEELDQQNKRFDCLKGEME---DDKSKMEKKESNLETELKSQTARIME-LED 1532
Query: 1218 HIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESL 1277
HI EIE L N V + ++ ++ K Q+ ++HFQ E ++
Sbjct: 1533 HITQKTI----EIESL---NEVLKNYNQQKDIEHKELVQK--LQHFQELGEEKDNR---- 1579
Query: 1278 VVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKK-IKQMEMRHAQREQELQQI 1336
V E E+IL EN MK + +KK ++ + + +E+EL+ +
Sbjct: 1580 -VKEAEEKIL-------------TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625
Query: 1337 IQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQ 1386
E E E +LA+LK + +K +L + E Q
Sbjct: 1626 ----------EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665
Score = 118 bits (295), Expect = 5e-26
Identities = 266/1287 (20%), Positives = 523/1287 (40%), Gaps = 188/1287 (14%)
Query: 7 EELDEEFEQFMKELS---DDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTN 63
E+ + E EQ +K L+ + E+ +K Q+K+ + +K+ + + E K+ +L
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930
Query: 64 VSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLD 123
+S K+ S ++ E E+ K Q K + + ET + + + + L L+
Sbjct: 931 LS---AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD-QEAKLKKELE 986
Query: 124 T--LEEQEEKEQFFAR-LEKGLTSSIDYSRLNKELDSNDSTHFKAL---HSNQANAELTD 177
LE ++++QF A+ LE +S S L++N ++L H + N ++
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI 1046
Query: 178 DEHENESKHEELAENYSDDFED-EYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGM 236
E + + EEL E + ++ E A L K ++ +++I+ K+E K
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 237 LANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAY 296
N + A VN QD+ K E E V +S + L +
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHL--EKLE-------VDLNKSLKENTFLQEQL 1157
Query: 297 CHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRI 356
+ L +EDK+K+ S +K++ + + K+ ++E ++L + + I
Sbjct: 1158 VELK-MLAEEDKRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
Query: 357 DSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQ 416
D+ +E + E K E + K N ILS+ S H K E ++++
Sbjct: 1216 Q------LDICCKKTEALLEAKTNELINISSSKTNA-ILSRIS-HCQHRTTKVKEALLIK 1267
Query: 417 KTTNESMENSCPQVTEVTAT-------EEHVDKMYLNILRKKITVNSSSLSQDDKINKT- 468
T +E Q+TE T H + N ++ S +++ + + K
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327
Query: 469 -YRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFST 527
+ Q +SE+E + + + +A L+K + + V S K + L +
Sbjct: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKE---KKVEISSLSKQLTDLNVQLQ 1384
Query: 528 LEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLI----------KPAALDKPAHKTES 577
SE K + S+ K E+L + + K +AL++ +
Sbjct: 1385 NSISLSE---KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 578 CLSTRKKSENP----TETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDK-WRGAQAL 632
+KK+++ T +Q Q + K++++ + K + ++K + +
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE 1501
Query: 633 IEQIKATFSEKEKELENKL----------EELKKQQEKELFKLNQ--DNYILQAKLSSFE 680
+E K+ +KE LE +L E+ Q+ E+ LN+ NY Q + E
Sbjct: 1502 MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 681 ETNKKQRWLHFGEAAD---PVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ 737
K Q + GE D EK+ ++ ++ + L+ ++E E + VK +E+
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
Query: 738 NKKNEERMFKENQSLFSEVASLKEQMH---KSRFLSQVVEDSEPTRN---QNFTDLLAEL 791
K E+R+ E+ + +E+ EQ K + LSQ+ E E + + ++L +L
Sbjct: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 792 RMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETH 851
+ ++E L E +K ++ + E + R AK+ AY E+ +++T+
Sbjct: 1682 QEREREVHILEEKLKSVESSQS------ETLIVPRS-AKNVAAYTEQEEADSQGCVQKTY 1734
Query: 852 KQEISRLQKRLQ-------------------------WYAENQELLDKDALRLREANEEI 886
+++IS LQ+ L Y E L+ + E I
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 887 EKLKLEIEK------------LKAESGNPSIRQKIRLKDKAADAKKI--------QDLER 926
L+ E+E+ ++ E G +I+ K L++ D +K Q LE+
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854
Query: 927 QVKEMEGILKRRYP-------------NSLPAL--ILAASAAGDTVDKNTVEFMEKRI-- 969
++KE++ L R+ L AL + + + +++NT E + +
Sbjct: 1855 KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQ 1914
Query: 970 KKLEADLEGKDEDAKKSLRTMEQQFQKM-----KIQYEQRL---EQQEQLLACKLNQHDS 1021
KL +++E + D + L E++ QK+ ++Q + R+ E Q++L K ++D
Sbjct: 1915 PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK-KEYDQ 1973
Query: 1022 PRIKALEKELDDIKEAHQITVRNLEAEIDVL---KHQNAELDVKK--NDKDDEDFQSIEF 1076
R + +++E +D++ H T++ L E + K Q E+ +K+ N + + + +E
Sbjct: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033
Query: 1077 QVEQAHAKAKLV------------RLNEELAAKKRE----IQDLSKTVERLQKDRRMMLS 1120
E+ + K + R E L A++ E ++DL +E LQK + L
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093
Query: 1121 NQNSKGRE-----EMSAKRAKKDVLHS 1142
+ + G + E+ + A+K L S
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLIS 2120
Score = 112 bits (281), Expect = 2e-24
Identities = 276/1508 (18%), Positives = 583/1508 (38%), Gaps = 220/1508 (14%)
Query: 6 QEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKD---TVPWWITEDDFKDDGLLGT 62
Q+EL ++ + + S E K + +KE+ +K+ T E +F++ +
Sbjct: 456 QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL 515
Query: 63 NVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGL 122
S + K SQ + E + E+++ K + +L+ + +L
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKA---ILTESENKLRDL-------------- 558
Query: 123 DTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHEN 182
Q+E E + R+ + L SS++ S + S D N+ N E+T ++
Sbjct: 559 -----QQEAETYRTRILE-LESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH 612
Query: 183 ESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEE----------- 231
+++ E L + ++ + E +E + EK ++ K +E
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 232 EKTGMLANV--VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDV 289
EKT +V L+SL S L + K+ + L + T+ + +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 290 EALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEE 349
+ + H + + +K + + ++ +K + +E+ ++ +E+D+ E
Sbjct: 733 QQQVDSIIK-EHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 350 LMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKN 409
++ + L S + A ++T+ + ++ +L D
Sbjct: 792 ELQQ--------ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL-----------DLE 832
Query: 410 DENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDK-INKT 468
E ++L K E TE+ A K+ + L +++ +S + Q K + +
Sbjct: 833 TERILLTKQVAEVEAQKKDVCTELDA-----HKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
Query: 469 YRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTL 528
Y S+L + KQ+ +K L R+ Q + K S +
Sbjct: 888 YESKLEDGNKEQEQTKQILVEKENMI--LQMREGQKKEIEILTQKLSAKEDSIHILNEEY 945
Query: 529 EKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENP 588
E K K + ++ + Q K+ L L + A L K T LS ++K N
Sbjct: 946 ETKFKNQEKKMEKVKQKAKEMQETLKKKL----LDQEAKLKKELENTALELSQKEKQFNA 1001
Query: 589 TETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELE 648
+ Q +S G + ++++ + R ++ S EK+L
Sbjct: 1002 KMLEMA---QANSAGISDAVSRLETNQKEQIESLTEVHR------RELNDVISIWEKKLN 1052
Query: 649 NKLEELKKQQEKELFKLNQDNYILQAKLSSF----EETNKKQRWLHFGEAADPVTGEKLK 704
+ EEL++ E +L + Q+ L+ K+ F EE NK+ WL T L
Sbjct: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT---LN 1109
Query: 705 QIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMH 764
++Q++++++ + Q+ +L ++ L+ K+ KEN L ++ LK
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS----LKENTFLQEQLVELKMLAE 1165
Query: 765 KSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQA-LEVDFEKMK 823
+ + + T ++ F L + + K + + K+L ++ L++ +K +
Sbjct: 1166 EDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE 1225
Query: 824 KERDQAKDQIAYVTGEKLYEI--KILEETHKQE------------ISRLQKRLQWYAENQ 869
+ +++ ++ K I +I H+ +S L+ +L+ E Q
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 870 ELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVK 929
L+ + ++A ++E+ + +I+ +KA+ + ++ K+ + + E +
Sbjct: 1286 NTLN---ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 930 EMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRT 989
+ LK+ ++ A+ L + K + + K++ L L+ SL
Sbjct: 1343 Q----LKKELSENINAVTLMKEELKEK--KVEISSLSKQLTDLNVQLQNSI-----SLSE 1391
Query: 990 MEQQFQKMKIQYEQR---LEQQEQLLACKLNQHDSPRIKALEKELDDIKEA--------- 1037
E ++ QY++ L Q Q L+ K++ +I ALE ++DD
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALE-QVDDWSNKFSEWKKKAQ 1450
Query: 1038 -----HQITVRNLEAEIDV------------------LKHQNAELDVKKNDKDDE----D 1070
HQ TV+ L+ ++++ L QN D K + +D+ +
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510
Query: 1071 FQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRM-------MLSNQN 1123
+ + E A+++ L + + K EI+ L++ ++ + + + L +
Sbjct: 1511 KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ 1570
Query: 1124 SKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSK---LYQPHTFTDSHVSEVLQENYRLK 1180
G E+ + + ++ + + + S L++K L + S E+ RL+
Sbjct: 1571 ELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE 1630
Query: 1181 NELEGLISE-KNELKMKSEAV----MNQFENSMRRVKEDTAAHIASLKASHQ---REI-- 1230
+E ++E K + + K A+ ++Q E + K+ T +H++ L Q RE+
Sbjct: 1631 SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690
Query: 1231 --EKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQ 1288
EKL +VE+S S+ + R ++ K +S ++ + +
Sbjct: 1691 LEEKL---KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 1289 KEITKLLEELREAKENHTPEMKHF-VGLEKKIKQMEMRHAQREQE--------LQQIIQQ 1339
KE KLL+ + + KE HF + + + + +++ HA+ +Q LQ+ +++
Sbjct: 1748 KE--KLLQRVGQEKEETVSS--HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803
Query: 1340 TH--------QVVETEQNK--------------EVEKWKRLAQLKNRELEKFRTELDSIL 1377
+ Q VE E K +V+K + +L + LE+ ELDS L
Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Query: 1378 DVLRELHR 1385
+E+HR
Sbjct: 1864 VRQKEVHR 1871
Score = 110 bits (276), Expect = 7e-24
Identities = 264/1391 (18%), Positives = 573/1391 (41%), Gaps = 169/1391 (12%)
Query: 129 EEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEE 188
EEK+Q+ + L+ + S+ RL + D K L + AE+ E ES E
Sbjct: 215 EEKDQYISVLQTQV--SLLKQRLRNGPMNVDV--LKPLPQLEPQAEVFTKEENPESDGEP 270
Query: 189 LAENYSDDFEDEYVGAPLTTKDEEMPS-KENSKSEKISVPKQEEEKTGMLANV-VLLDSL 246
+ E+ + E + + ++ + KE +S K EK + + L L
Sbjct: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL 330
Query: 247 DSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDV-EALHQAYCHIAH---- 301
+ + ++++ E+ K+ + R + E G+ ++ + E L IA
Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
Query: 302 -----SLGDE---DKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKP 353
+ G+E K+K E E+++ ++ + E K + M+ + T+E+ +
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 354 IRIDSFGISGFDLQPVSSEKV-AERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDEN 412
RI +L V E V +K +E + K++ L++ Q + +
Sbjct: 451 ERIS----LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506
Query: 413 VILQKTTNESMENSCPQVTEVTATEEHVDKMYLN--ILRKK--ITVNSSSLSQDDKINKT 468
Q+ ++E S + +++ +E + + L L+KK +T + + L + +T
Sbjct: 507 --FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAET 564
Query: 469 YRSQLSSEEEGAVMGKQVPYKKARS-APPLLKRKPQSGLYASVRSSGYGKPSSPLKMFST 527
YR+++ E Q +++ A L K + +V + LK
Sbjct: 565 YRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD 624
Query: 528 LEKKTSEDIIKSK---NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKT--------- 575
++K + + + + K+ +L ++I A +++ KT
Sbjct: 625 ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQT 684
Query: 576 -----ESCLSTRKKSENPTETD-SCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGA 629
S LS K+ + E + S ++ QTD K K+ L K ++ +
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTD--------KMKQELEAKMDEQKNHHQQQV 736
Query: 630 QALIEQIKATFSEKEKELE---NKLEELKKQQEKELFKLNQDNYILQAKLSSFE-ETNKK 685
++I++ + + EK L+ N+LE L K+++K L + L+A + E E +
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 686 QRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNK------ 739
L ++ T E+ K ++++ + + L + E L QV +++ Q K
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 740 --------KNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRN--QNFTDLLA 789
+++ K+N + +V SL Q+++S+ L ++ E T+ +++
Sbjct: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSL-TQVYESK-LEDGNKEQEQTKQILVEKENMIL 914
Query: 790 ELRMAQKEKDSLLEDIKRLKQD-----KQALEVDF----EKMKKERDQAKDQIAYVTGEK 840
++R QK++ +L K+D + E F +KM+K + +AK+ + +
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974
Query: 841 L-YEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIE-KLKLEIEKL-- 896
L E K+ +E + QK Q+ A+ E+ ++ + +A +E K +IE L
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 897 --KAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEME-GILKRRY------PNSLPALI 947
+ E + + +L +A + ++I +++ Q KE E LK++ + I
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Query: 948 LAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQ 1007
G D T+ +++++K+ A + +D K ++ +K+++ + L++
Sbjct: 1095 TWLKEEGVKQD-TTLNELQEQLKQKSAHVNSLAQDETK----LKAHLEKLEVDLNKSLKE 1149
Query: 1008 ----QEQLLACKLNQHDSPR--------IKALEKELDDIKEAHQITVRNLE--------- 1046
QEQL+ K+ + R +K ++E +K +H+ + ++LE
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 1047 -----AEIDV-LKHQNAELDVKKNDKDDEDFQSIEFQVEQ-AHAKAKLVRLNEELAAKKR 1099
++D+ K A L+ K N+ + + + +H + + ++ E L K
Sbjct: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 1100 EIQDLSKTVERLQKDRRMM-------------LSNQNSKGREEMSAKRAKKDVLHSSKGN 1146
+ +L + +L +++ + NQ + ++ + +K+ L GN
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329
Query: 1147 ANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFEN 1206
+S + Q +SE + +K EL+ E + L + + Q +N
Sbjct: 1330 QQQAASEKESCITQ----LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 1207 SMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQ 1266
S+ +++ A I+SL+ + E +LL Q V++ S KV L+++ + + + ++
Sbjct: 1386 SISLSEKEAA--ISSLRKQYDEEKCELLDQ--VQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 1267 VNELQSKQESLVVS--------EVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKK 1318
+E + K +S +++ E+ KE + E++ KE + K F L+ +
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE 1501
Query: 1319 IKQMEMRHAQREQELQ-QIIQQTHQVVE-----TEQNKEVEKWKRLAQLKNRELEKFRTE 1372
++ + + ++E L+ ++ QT +++E T++ E+E + + N++ + E
Sbjct: 1502 MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 1373 LDSILDVLREL 1383
L L +EL
Sbjct: 1562 LVQKLQHFQEL 1572
Score = 105 bits (263), Expect = 2e-22
Identities = 193/1001 (19%), Positives = 422/1001 (42%), Gaps = 141/1001 (14%)
Query: 459 LSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKP 518
+ D +NK Q E ++ + Y + +A +L+R+ + + S K
Sbjct: 128 VGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKK--LQGILSQSQDKS 185
Query: 519 SSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILS----GTKLIK------PAAL 568
L+ + L ++ D K+L+ ++ K + +S L+K P +
Sbjct: 186 ---LRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNV 242
Query: 569 D--KPAHKTESCLSTRKKSENP-TETDSCIQFQTD--SLGYCGENKEKKLLMFKRVQEAE 623
D KP + E K ENP ++ + ++ T +L + +++ + KR +E
Sbjct: 243 DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKET- 301
Query: 624 DKWRGAQALIEQIKATFSEKE---KELENKLEELKKQQEKELFKLNQDNYILQAKLSSFE 680
Q+ EQ SEKE ++L+ +L+EL+K K+L + I Q +
Sbjct: 302 -----IQSHKEQCTLLTSEKEALQEQLDERLQELEKI--KDLHMAEKTKLITQLR----- 349
Query: 681 ETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKK 740
+ K + V E +Q+ + ++ +E + + +++ Q ++L+EQ +K
Sbjct: 350 --DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 741 NEERMFKENQSLFSEVASLKEQMHKSRF-LSQVVEDSEPTRNQNFTDLLAELRMAQKEKD 799
+E F+E + S +E K + + + ++ E T +++E+
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT--------------SEEERI 453
Query: 800 SLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQ 859
SL +++ R+KQ+ VD K E AK L++ H++E++R +
Sbjct: 454 SLQQELSRVKQE----VVDVMKKSSEEQIAK----------------LQKLHEKELARKE 493
Query: 860 KRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKA---A 916
+ L + +E ++ +++ + E LK+ EK + ES +++ L+ KA
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES---LALEELELQKKAILTE 550
Query: 917 DAKKIQDLERQ-------VKEMEGILKR---RYPNSLPALILAASAAGDTVDKNTVEFME 966
K++DL+++ + E+E L++ N L + A + +K +E
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
Query: 967 KRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLAC-----------K 1015
K +LE+ +D + L+ ++QQ+Q + ++ EQ+++ L +
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 1016 LNQHDSPRIKALEKELDDIKEAHQITVR---NLEAEIDVLKHQNAELDVKKNDKDDEDFQ 1072
+N+ ++ + EL+ + ++ LE E+ VLK Q ++ + K DE
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 1073 SIEFQVEQ--AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNS---KGR 1127
+ QV+ + + R + L + +++ L K ++ K+ + + N + +
Sbjct: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 1128 EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQ-PHTFTDSHVSEVL--QENYRLKNELE 1184
E+ AK DV S + + + +L Q D +L ++ ++ + +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 1185 GLISEKNELKMKSEAVMNQFENS----MRRVKEDTAAHIASLKASH--QREIEKLLC--Q 1236
+ +E + K++ + +M Q E ++VK T + + L+ + Q + +++L +
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 1237 NAV----ENSSSKVAELNRKIATQE----VLIRHFQSQVNELQSKQESL-VVSEVREEIL 1287
N + E ++ L +K++ +E +L ++++ + K E + ++ +E L
Sbjct: 911 NMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970
Query: 1288 QKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETE 1347
+K++ +L++ EN E L +K KQ + + Q I +ET
Sbjct: 971 KKKLLDQEAKLKKELENTALE------LSQKEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
Query: 1348 QNKEVEKWKRLAQLKNRELEK----FRTELDSILDVLRELH 1384
Q +++E L ++ REL + +L+ + L+E+H
Sbjct: 1025 QKEQIES---LTEVHRRELNDVISIWEKKLNQQAEELQEIH 1062
Score = 103 bits (257), Expect = 1e-21
Identities = 276/1297 (21%), Positives = 513/1297 (39%), Gaps = 205/1297 (15%)
Query: 173 AELTDDEHENESKHEELAENYS--------DDFEDEYVGAPLTTKDEEMPSKENSKSEKI 224
++L D E E + L E + E E + L+ K++ + K
Sbjct: 890 SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF 949
Query: 225 SVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQ 284
+++ EK A + +++ + LD++ K+ E E T +S +
Sbjct: 950 KNQEKKMEKVKQKAK----EMQETLKKKLLDQEAKLKK---------ELENTALELSQKE 996
Query: 285 SSSDVEALHQAYCHIAHSLGDEDK-QKIESNTVEDIKSSVKGHPQENEENSKNISTMESD 343
+ + L A A+S G D ++E+N E I+S + H +E + IS E
Sbjct: 997 KQFNAKMLEMAQ---ANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV---ISIWEKK 1050
Query: 344 L-PTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHV 402
L EEL + I LQ E +++ F +MN I
Sbjct: 1051 LNQQAEELQE--------IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL----- 1097
Query: 403 NLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQD 462
+E V T NE E + V + + K+ ++ + ++ +N S
Sbjct: 1098 ------KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 463 DKINKTYRSQLSSEEEGAVMGKQVPYKKARSAP--PLLKRKPQSGLYASVRSSGYGKPSS 520
+ ++ +EE+ + + K L +S +S + K S
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 521 PLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSG-------TKLIKPAALDKPAH 573
L + + K +E ++++K I+ S+ + ILS T +K A L K
Sbjct: 1212 ELAIQLDICCKKTEALLEAKTNELINISSS-KTNAILSRISHCQHRTTKVKEALLIKTCT 1270
Query: 574 KTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKR-------VQEAEDKW 626
+E R+ +E + Q T L E KE ++ K +EA K
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQL----EEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 627 RGAQ--------ALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSS 678
G Q + I Q+K SE + EELK +++ E+ L++ L +L +
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-EKKVEISSLSKQLTDLNVQLQN 1385
Query: 679 FEETNKKQRWLH-FGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ 737
++K+ + + D E L Q+Q + +TL + E++ + E
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 738 NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKE 797
KK + R F ++Q+ E+ E K + +++ L EL K
Sbjct: 1446 KKKAQSR-FTQHQNTVKELQIQLELKSKEAY----------EKDEQINLLKEELDQQNKR 1494
Query: 798 KDSL---LEDIKRLKQDKQA-LEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQ 853
D L +ED K + K++ LE + + + +D I T E ++L+ ++Q
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554
Query: 854 EISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKD 913
+ ++ +Q QEL ++ R++EA E+I L+ ++ +KAE L+
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE-----------LET 1603
Query: 914 KAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK-L 972
K K+++ + VK E LK +L + + SAA K E IKK L
Sbjct: 1604 K---KKELEHVNLSVKSKEEELK-----ALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 973 EADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKAL----- 1027
+ +E K+E KK E ++ + ++R E++ +L KL +S + + L
Sbjct: 1656 LSQMEEKEEQYKKG---TESHLSELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRS 1711
Query: 1028 --------EKELDDIKEAHQITVRNLEAEIDVLKHQNAELD--VKKNDKDDEDFQSIEFQ 1077
E+E D + Q + E +I VL+ E + +++ ++ E+ S F+
Sbjct: 1712 AKNVAAYTEQEEADSQGCVQ---KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFE 1768
Query: 1078 VEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKK 1137
+ + + +L++L E AK+ E Q + + LQ EE+ K K
Sbjct: 1769 M-RCQYQERLIKL-EHAEAKQHEDQSM---IGHLQ---------------EELEEKNKKY 1808
Query: 1138 DVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKS 1197
++ + + +K + F D V + LQE LE I E + ++
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENVFDD--VQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 1198 EAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQE 1257
+ V R E+ + L+A Q + + EN+ K ++ Q
Sbjct: 1867 KEV-------HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK----SKSHLVQP 1915
Query: 1258 VLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM-----KHF 1312
L+ + ++Q N+L+ K L +E ++ L KEI +L ++LR ++ H E+ ++
Sbjct: 1916 KLLSNMEAQHNDLEFK---LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 1313 VGLEKKIKQ----MEMRH---------------AQREQELQQIIQQT--------HQVVE 1345
E+KIKQ +E++H AQ+EQEL+ I++T +++E
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE 2032
Query: 1346 TEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRE 1382
+ Q + + K++A+ K+ +L++ + ILD E
Sbjct: 2033 SHQEETNQLLKKIAE-KDDDLKRTAKRYEEILDAREE 2068
Score = 82.4 bits (202), Expect = 3e-15
Identities = 155/782 (19%), Positives = 314/782 (40%), Gaps = 125/782 (15%)
Query: 652 EELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVT-----------G 700
++LK++ +E +L Q QA +S T + R F E D T
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 701 EKLKQIQKEIQE------QETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFS 754
+KL+ ++ +E+L + +E+ + + L + + F + S
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
Query: 755 EVASL---KEQMHKSRFLSQV--VEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK 809
E L + ++K + + ++ +E S + +++L+ +M Q+EK L + I
Sbjct: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL-QGILSQS 181
Query: 810 QDKQALEVDFEKMKKERDQ-AKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAEN 868
QDK + + + + DQ AK + L E + ++S L++RL+ N
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMN 241
Query: 869 QELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQV 928
++L K +L E K E+ G P + + K ++ L+++V
Sbjct: 242 VDVL-KPLPQLEPQAEVFTK-----EENPESDGEPVV-------EDGTSVKTLETLQQRV 288
Query: 929 KEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLR 988
K E +LKR K T++ +++ L ++ E E + L+
Sbjct: 289 KRQENLLKRC--------------------KETIQSHKEQCTLLTSEKEALQEQLDERLQ 328
Query: 989 TMEQ---QFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNL 1045
+E+ K + +L + L+ +L Q I ++++ + E + + L
Sbjct: 329 ELEKIKDLHMAEKTKLITQLRDAKNLIE-QLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 1046 EAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
+ I + Q EL +K + F+ +E + A + E K E+ +
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ------KTEEARRKLKAEMDEQI 441
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEM--------SAKRAKKDVLHSSKGNANSFPGTLDSK 1157
KT+E+ ++ R+ L + S+ ++E+ + AK LH + L K
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE--QELTKK 499
Query: 1158 LYQPHTFTDSHVSEVLQENY-------RLKNELEGLISEKNELKMKSEAVMNQFENSMRR 1210
L + L+++ + K + E L E EL+++ +A++ + EN +R
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE--ELELQKKAILTESENKLRD 557
Query: 1211 VKEDTAAH---IASLKASHQREIEKLLCQNAVENSSSKV---AELNRKIATQEVLIRHFQ 1264
++++ + I L++S +EK L +N ++ V AE N+ V++ +
Sbjct: 558 LQQEAETYRTRILELESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 1265 SQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEM 1324
+++ L+ +Q++L ++ ++L+++ +E+LRE E E +K E
Sbjct: 614 TELESLKHQQDALWTEKL--QVLKQQYQTEMEKLREKCEQEK---------ETLLKDKE- 661
Query: 1325 RHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELH 1384
II Q H +E K +EK +K ELE +EL +L +L
Sbjct: 662 -----------IIFQAH--IEEMNEKTLEK----LDVKQTELESLSSELSEVLKARHKLE 704
Query: 1385 RQ 1386
+
Sbjct: 705 EE 706
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1809
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1918
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1977
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1978 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2150 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2205 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2378
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2614
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2615 VTASQ 2619
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1649
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1650 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1868
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1869 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1903
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2022
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2023 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2061
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1348
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1526
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1587 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1634
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1635 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1676
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1677 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1733
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1734 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1845
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1906 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1948
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2069 LQQEQSVLDQLR 2080
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 1013
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1074 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1182
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1303 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1341
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1460 QLEATERQRGGAEGELQALR 1479
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1813
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1922
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1981
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1982 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2154 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2209 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2265
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2382
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2442
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2562
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2618
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2619 VTASQ 2623
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1602 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1653
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1654 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1872
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1873 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1907
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2026
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2027 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2065
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1352
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1530
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1590
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1591 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1638
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1639 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1680
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1681 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1737
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1738 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1849
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1910 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1952
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2073 LQQEQSVLDQLR 2084
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 1017
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1078 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1186
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1307 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1345
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1403
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1464 QLEATERQRGGAEGELQALR 1483
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1809
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1918
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1977
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1978 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2150 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2205 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2378
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2614
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2615 VTASQ 2619
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1649
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1650 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1868
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1869 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1903
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2022
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2023 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2061
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1348
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1526
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1587 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1634
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1635 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1676
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1677 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1733
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1734 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1845
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1906 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1948
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2069 LQQEQSVLDQLR 2080
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 1013
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1074 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1182
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1303 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1341
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1460 QLEATERQRGGAEGELQALR 1479
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1777
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1886
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1945
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1946 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2118 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2173 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2229
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2346
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2406
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2526
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2582
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2583 VTASQ 2587
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1566 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1617
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1618 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1836
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1837 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1871
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 1990
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 1991 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2029
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1316
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1494
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1554
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1555 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1602
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1603 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1644
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1645 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1701
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1702 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1813
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1874 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1916
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2037 LQQEQSVLDQLR 2048
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 981
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1042 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1150
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1271 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1309
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1367
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1428 QLEATERQRGGAEGELQALR 1447
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1946
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 2055
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 2114
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 2115 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2287 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2342 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2515
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2575
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2695
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2751
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2752 VTASQ 2756
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1735 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1786
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1787 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 2005
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 2006 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 2040
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2159
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2160 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2198
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1485
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1663
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1723
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1724 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1771
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1772 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1813
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1814 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1870
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1871 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1982
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 2043 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 2085
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2206 LQQEQSVLDQLR 2217
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 1150
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1211 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1319
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1440 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1478
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1597 QLEATERQRGGAEGELQALR 1616
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1787
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1896
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1955
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1956 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2128 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2183 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2356
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2416
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2592
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2593 VTASQ 2597
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1576 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1627
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1628 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1846
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1847 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1881
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2000
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2001 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2039
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1326
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1504
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1564
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1565 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1612
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1613 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1654
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1655 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1711
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1712 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1823
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1884 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1926
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2047 LQQEQSVLDQLR 2058
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 933 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 991
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1052 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1160
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1281 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1319
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1438 QLEATERQRGGAEGELQALR 1457
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1795
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1904
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 1963
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 1964 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2136 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2191 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2247
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2364
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2424
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2544
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2600
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2601 VTASQ 2605
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1584 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1635
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1636 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1805
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1854
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1855 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1889
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2008
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2009 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2047
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1334
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1512
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1572
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1573 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1620
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1621 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1662
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1663 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1719
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1720 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1831
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1891
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1892 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1934
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2055 LQQEQSVLDQLR 2066
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 941 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 999
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1060 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1168
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1288
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1289 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1327
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1446 QLEATERQRGGAEGELQALR 1465
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 119 bits (297), Expect = 3e-26
Identities = 194/905 (21%), Positives = 384/905 (42%), Gaps = 158/905 (17%)
Query: 620 QEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF 679
QE E + +A +E + A+ + E+E + E+ K++ E E + ++ A+L +
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARLRAL 1836
Query: 680 EETNKKQRWLHFGEAA------DPVTGEKLKQIQKEIQ---EQETLLQGYQQENERLYNQ 730
E K+QR L +AA + V EKL I + + E E L+ + ENERL
Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896
Query: 731 VKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT-DLLA 789
+D Q ++ EE+ + + +A L++ DSE R + D L
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----------ASDSELERQKGLVEDTLR 1945
Query: 790 ELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD---QAKDQIAYVTGEKLYEIKI 846
+ R ++E +L ++ K LE++ +++ + ++K+Q A + + ++
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ-AELEAARQRQLAA 2004
Query: 847 LEETHKQEIS-RLQKRLQWYAENQELLDKDALRLREAN-EEIEKLKLEIE---KLKAESG 901
EE ++E R+QK L +++A R R+A EE+E+LK ++E +L+ +
Sbjct: 2005 EEERRRREAEERVQKSLA--------AEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 902 NPSIRQ----------KIRLKDKA---ADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
S RQ +++ ++KA A +K Q+L++ +++ + +L + + A
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
A A V +R + L+ E+ ++ + +K++ + EQ ++
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176
Query: 1009 EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRN---LEAEIDVLKHQNAELDVKKND 1065
Q L Q +A + E++ K+ + T+R +E E+ L+ Q E D +KN
Sbjct: 2177 AQAEQAALRQK-----QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 1066 KDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR-MMLSNQNS 1124
D+E + E A + ++ EEL + + ++++LSK R++ + R ++L ++++
Sbjct: 2232 LDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
Query: 1125 KGR------EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE---VLQE 1175
R E+M + L + A + L Q + + E +QE
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
RLK E E L +K + ++ + E +++ E+T +L+A QR++E
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM--- 2405
Query: 1236 QNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSK---------------------- 1273
E +VAE++R A E + F+ Q E+ K
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2465
Query: 1274 ----------QESLVVSEVREEILQKEIT---------------KLLEELREAKENHTPE 1308
+E++ E +E LQ+E +LL+E + +++ E
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Query: 1309 ------MKHFVGLEK-KIKQMEMRHAQREQELQQIIQQTHQVVETEQNK----------- 1350
+ F+ EK K++Q+ + Q+L++ Q+ Q +E E+ +
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2585
Query: 1351 --EVEKWKRLAQLKNRELEKFRTELDSI-----------LDVLRELHRQGVVVPVAFADE 1397
E E+ R Q + ++LE+ R + + + L +L E HR +A ++E
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEE 2641
Query: 1398 MNAPE 1402
+ A +
Sbjct: 2642 VTASQ 2646
Score = 110 bits (276), Expect = 7e-24
Identities = 185/877 (21%), Positives = 369/877 (42%), Gaps = 134/877 (15%)
Query: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHK--TESCLSTRKKSENPTETDSCIQFQT 599
LR+ + + +K++ + ++ D+ K E L++R K+E + Q
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 600 -DSLGYCGENKEKKLLMF-----KRVQEA-EDKWRGAQALIEQIKATFSEKEKELENKLE 652
+ L E E++L ++VQ A E R A+A ++ +A+F+EK +LE L+
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 653 E---LKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRW-LHFGEAADPVTGEKLKQIQK 708
E Q +E + Q +A+ + E + +RW L EA +L+ +
Sbjct: 1625 EEHVAVAQLREEAERRAQQQ--AEAERAREEAERELERWQLKANEAL------RLRLQAE 1676
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
E+ +Q++L Q + + +E+ ++ R K + + ++++ K R
Sbjct: 1677 EVAQQKSLAQA----------EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK-------QDKQALEVDFEK 821
L++ Q L AE ++++ L E++ RL+ Q +Q LE + K
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786
Query: 822 MKKERD------QAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAE----NQEL 871
++ E + ++ + T EK + E +E++ RL+ AE ++L
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1846
Query: 872 LDKDALRLREANEEIEKLKL----EIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQ 927
++DA R R E + KL E +LK E+ +I LK+K A+ +++ R+
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEA-------EIALKEKEAENERL----RR 1895
Query: 928 VKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSL 987
+ E E +RR L AA D +E+R+ +L K S
Sbjct: 1896 LAEDEAFQRRR---------LEEQAAQHKAD------IEERLAQLR----------KASD 1930
Query: 988 RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA-LEKELDDIKEAHQITVRNLE 1046
+E+Q ++ QR + +E++LA K + + KA LE EL I+ + T+R+ E
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 1047 -AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
AE++ + + + ++ ++ E+ E+ A+ + L EE+ K ++++
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEAR 2049
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFT 1165
+ ER + Q S + +++ + A+K + K +A +
Sbjct: 2050 RLRER---------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ------------K 2088
Query: 1166 DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE----NSMRRVKE-----DTA 1216
+ + + LQ+ + ++L G ++E Q E S R+V+E +A
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 1217 AHIASLKASHQREIEKL---LCQNAVENSSSKVAELNRKIATQEVLIRH--FQSQV---- 1267
A +A Q EKL Q A + ++ A L +K A + +H F Q
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208
Query: 1268 ----NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
EL + + L ++ ++ +L +E+ +L E EA + + + +++++
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQ 1360
A+ E E + +I + + +E EK K++A+
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
Score = 105 bits (261), Expect = 4e-22
Identities = 180/852 (21%), Positives = 349/852 (40%), Gaps = 94/852 (11%)
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK 611
+K ++ SG++ + +D H SE T T I+F +++L E E+
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHY----------SELTTLTSQYIKFISETLRRMEE--EE 1375
Query: 612 KLLMFKRVQEAE---------DKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKEL 662
+L +R +E E +K R Q KA + KEL+ +++E ++E+
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 663 FKLNQDNYILQAKL-----SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLL 717
Q +Q +L SS E K R E + E+++ ++ +++ E
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495
Query: 718 QGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777
G + E + L + ++ + Q ++ +E + + + E S +++ + S+V ++E
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE--SQRKRQAEVELASRVKAEAE 1553
Query: 778 PTRN-QNFTDLLAELRMAQKEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIA 834
R Q L ELR+ +E + L +++R +Q + ALE + E + A
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1613
Query: 835 YVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIE 894
T + + L+E H +++L++ + A+ Q ++ A EE E+ +LE
Sbjct: 1614 EKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAER-------AREEAER-ELERW 1661
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAA 953
+LKA N ++R +++ ++ A Q + E+Q +E E +RR
Sbjct: 1662 QLKA---NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------------- 1703
Query: 954 GDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLA 1013
++ V E ++LE + + A++ L EQ+ +++ + EQ EQQ QLL
Sbjct: 1704 -GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA-EQELIRLRAETEQG-EQQRQLLE 1760
Query: 1014 CKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQS 1073
+L + A +K + EA VR AE++VL A + + ++ Q
Sbjct: 1761 EELARLQREAAAATQKRQE--LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 1074 IEFQV----EQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREE 1129
+E + E A A+L L EE A ++R++ + +R + +R +L+ + + E
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAER--VLAEKLAAIGEA 1872
Query: 1130 MSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE 1189
K + L + + + +Q + RL + SE
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1932
Query: 1190 KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAEL 1249
K E + Q R+V+E+ I +LKAS ++ A + EL
Sbjct: 1933 LERQKGLVEDTLRQ----RRQVEEE----ILALKASFEK---------AAAGKAELELEL 1975
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
R + E +R + E +++ E R ++ + K L EA +
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF 1369
+ L+ K+++ + EQE + +Q + + E + Q K +EL++
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 1370 RTELDSILDVLR 1381
+ S+LD LR
Sbjct: 2096 LQQEQSVLDQLR 2107
Score = 34.3 bits (77), Expect = 0.86
Identities = 92/560 (16%), Positives = 213/560 (38%), Gaps = 65/560 (11%)
Query: 852 KQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRL 911
++E Q ++ E ++ R + E++ ++L++E + + + +R +
Sbjct: 982 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH-RLRLPLDK 1040
Query: 912 KDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
+ A++I + ++ E+EG+ K S A + A +E + K
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 972 LEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
LE + + L+T+ + + E +EQL + P ++A + L
Sbjct: 1101 LE-QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
Query: 1032 DDIK---EAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ EA Q T L E+ + L + ++D VE + ++
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD----------VEVERWRERVA 1209
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
+L E A + + +E+L + R + + G A+R ++ + ++
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 1149 SFPGTL-------------DSKLYQPHTFTDSHVSEVLQENYRL---KNELEGLIS--EK 1190
+ L K+ + F +++ + +L K +LE + S +K
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
Query: 1191 NELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELN 1250
+++ SE+V+ ++ D H + L + I+ ++E
Sbjct: 1330 PKVQSGSESVIQEYV--------DLRTHYSELTTLTSQYIKF-------------ISETL 1368
Query: 1251 RKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMK 1310
R++ +E L +++ E ++ E+ + E + ++ + + REAKE +
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAAL--EKQRQLAEAHAQAKAQAEREAKELQQRMQE 1426
Query: 1311 HFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNK---------EVEKWKRLAQL 1361
V E+ + + ++ELQQ+ Q + ++ + + +E+ R+ +L
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486
Query: 1362 KNRELEKFRTELDSILDVLR 1381
+ E+ R + L LR
Sbjct: 1487 QLEATERQRGGAEGELQALR 1506
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 118 bits (295), Expect = 5e-26
Identities = 213/944 (22%), Positives = 409/944 (43%), Gaps = 200/944 (21%)
Query: 610 EKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFK---LN 666
E+K ++ +++Q + + A E+++A + K++ELE L +L+ + E+E + L
Sbjct: 887 EEKNILAEQLQAETELFAEA----EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942
Query: 667 QDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGE-KLKQIQKEIQEQETLLQGYQQENE 725
+ +QA + EE ++ + VT E K+K++++EI E + +E +
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002
Query: 726 RLYNQVKDLQEQNKKNEER---MFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQ 782
+ +++ + Q + EE+ + K ++ L+E++ K Q +E ++ +
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 783 NFTDL---LAELR---------MAQKE----------------KDSLLEDIKRLKQDKQA 814
TDL +AEL+ +A+KE K++ L+ ++ L+
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 815 LEVDFEKMKKERDQAKDQIAYVTGEKLYEIKI-LEET-------------HKQEISRLQK 860
L+ DFE K R++A+ Q ++ E+L +K LE+T +QE++ L+K
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLS-EELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 861 RLQWYAEN-----QELLDKDALRLREANEEIEKLK-----LEIEKLKAESGNPSIRQKIR 910
L+ +N Q++ + A L E +E++E+ K LE K E+ N + +++
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 911 LKD--KAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKR 968
+ KA K + L+ QV+E+ A + GD + VE EK
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELH----------------AKVSEGDRL---RVELAEKA 1282
Query: 969 IKKLEADLEGK----DEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQ--HDSP 1022
KL+ +L+ +E KK ++ F K E +L+ ++LL + Q + S
Sbjct: 1283 -SKLQNELDNVSTLLEEAEKKGIK-----FAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 1023 RIKALEKE---LDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVE 1079
RI+ LE+E L + +E + +NLE ++ L+ Q A D KK K D+D +IE E
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA--DTKK--KVDDDLGTIESLEE 1392
Query: 1080 QAHAKAKLVR----LNEELAAKKREIQDLSKTVERLQKD----------RRMMLSNQNSK 1125
AK KL++ L++ L K L KT RLQ++ +R + SN K
Sbjct: 1393 ---AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 1126 GRE---------EMSAKRAKKD-----VLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSE 1171
++ +SA+ A++ + A S L+ L F
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE------ 1503
Query: 1172 VLQENYRLKNELEGLISEKN-------ELKMKSEAVMNQFENSMRRVKE----------- 1213
++N +L+ ++E L+S K+ EL+ A+ Q E +++E
Sbjct: 1504 --RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 1214 --DTAAHIASLKASHQREIEKLLCQNAVENSS--SKVAELNRKIATQ------------- 1256
++ ++KA +R+++ QN + +V EL ++ +
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 1257 -EVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGL 1315
E+ ++ ++Q+ E +K V+ ++R+ LQ ++ EL EA+ +
Sbjct: 1622 MEIDLKDLEAQI-EAANKARDEVIKQLRK--LQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 1316 EKKIKQMEMRHAQREQEL-----------QQIIQQTHQVVETEQNKEV---EKWK---RL 1358
EKK+K +E Q ++EL Q+ + ++ + K EK + R+
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 1359 AQLKNRELEKFRTELDSILDVLRELHRQGVVVPVAFADEMNAPE 1402
AQL+ ELE+ ++ ++ + D R+ Q + A E +A +
Sbjct: 1739 AQLE-EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Score = 113 bits (282), Expect = 1e-24
Identities = 176/808 (21%), Positives = 357/808 (44%), Gaps = 89/808 (11%)
Query: 609 KEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQ---EKELFKL 665
+E+++ K+ E E K AQ I+ ++ + +EL +LE+ K+ + EK L
Sbjct: 1172 REQEVAELKKALEEETKNHEAQ--IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Query: 666 NQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENE 725
DN L ++ ++ + H + D +++++ ++ E + L ++
Sbjct: 1230 ETDNKELACEVKVLQQVKAESE--HKRKKLDA----QVQELHAKVSEGDRLRVELAEKAS 1283
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT 785
+L N++ ++ ++ E++ K + ASL+ Q+ ++ L Q E TR +
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIK----FAKDAASLESQLQDTQELLQ-----EETRQK--L 1332
Query: 786 DLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK 845
+L + +R ++EK+SL E + ++ ++ LE ++ + K ++ + L I+
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV----DDDLGTIE 1388
Query: 846 ILEETHKQ---EISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
LEE K+ + L +RL+ A + L+K RL++ E++ L ++++ + + N
Sbjct: 1389 SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ---ELDDLTVDLDHQRQVASN 1445
Query: 903 PSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTV 962
+QK + A+ K I R +E + AL LA + K
Sbjct: 1446 LEKKQK-KFDQLLAEEKSIS--ARYAEERDRAEAEAREKETKALSLARALEEALEAK--- 1499
Query: 963 EFMEKRIKKLEADLE----GKDEDAK------KSLRTMEQQFQKMKIQYEQRLEQQEQLL 1012
E E++ K+L AD+E KD+ K KS R +EQQ ++M+ Q E+ ++ +
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 1013 ACKLN-QHDSPRIKA-LEKELDDIKEAHQIT-------VRNLEAEIDVLKHQNAELDVKK 1063
KL + + +KA E++L E ++ VR LEAE++ + Q A L V
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA-LAVAS 1618
Query: 1064 NDKDDEDFQSIEFQVEQAH-AKAKLVRLNEELAAKKREIQ-DLSKTVERLQKDRRMMLSN 1121
K + D + +E Q+E A+ A+ ++++ +L A+ ++ Q +L + R +D S
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA--RASRDEIFAQSK 1676
Query: 1122 QNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKN 1181
++ K + + A+ + +S A +L T + S S +L E RL+
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736
Query: 1182 ELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVEN 1241
+ L E E + E + ++F + +V + A +A+ +++ Q+ NA +
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQV-DTLNAELAAERSAAQKS------DNARQQ 1789
Query: 1242 SSSKVAELNRKIATQEVLIRH-FQSQVNELQSKQESLVVSEVREEILQKEITKLLEELRE 1300
+ EL K+ E ++ F++ ++ L++K I +L E+L +
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAK-----------------IGQLEEQLEQ 1832
Query: 1301 AKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVE--TEQNKEVEKWKRL 1358
+ K EKK+K++ M+ + Q +Q + + +++E+ +
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 1359 AQLKNRELEKFRTELDSILDVLRELHRQ 1386
A N K + ELD + L R+
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSRE 1920
Score = 108 bits (270), Expect = 4e-23
Identities = 186/849 (21%), Positives = 355/849 (41%), Gaps = 137/849 (16%)
Query: 591 TDSCIQFQTDSLGYCGEN----KEKKLLMFKRVQE---AEDKWRGAQ--ALIEQIKATF- 640
TD I FQ GY K+++L K +Q A K R Q + ++K
Sbjct: 787 TDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQ 846
Query: 641 -SEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSS-FEETNKKQRWLHFGEAADPV 698
+ +E+EL+ K EEL K +EK Q K+ EE +K + L +
Sbjct: 847 VTRQEEELQAKDEELLKVKEK------------QTKVEGELEEMERKHQQLL---EEKNI 891
Query: 699 TGEKLK---QIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSE 755
E+L+ ++ E +E L +QE E + + ++ E+ ++ + + E + + +
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 756 VASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQAL 815
+ L+EQ+ ++ E R + Q EK + IK+++++ L
Sbjct: 952 IQDLEEQL----------DEEEGARQK-----------LQLEKVTAEAKIKKMEEEILLL 990
Query: 816 EVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKD 875
E K KE+ +D+IA + + + EE K K L QE++ D
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQ------LAEEEEK------AKNLAKIRNKQEVMISD 1038
Query: 876 ALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL 935
L R EE + +LE K K + ++ +I D K+Q L ++ +E++G L
Sbjct: 1039 -LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ-LAKKEEELQGAL 1096
Query: 936 KRRYPNSLPALILAASAAGDTVDKN----TVEFMEKRIKKLEADLEGKD---EDAKKSLR 988
R +T+ KN V ++ +I +L+ D E + A+K R
Sbjct: 1097 AR--------------GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 989 TMEQQFQKMKIQYEQRLE--QQEQLLACKLNQHDSPRIKALEKE-------LDDIKEAHQ 1039
+ ++ + +K + E L+ +Q L K Q + KALE+E + D+++ H
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 1040 ITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSI-------EFQVEQAHAKAKLVRLNE 1092
+ L +++ K A L+ K + ++ + + + E H + KL +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 1093 ELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPG 1152
EL AK E L VE +K ++ QN + A+K + +K A+
Sbjct: 1263 ELHAKVSEGDRL--RVELAEKASKL----QNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1153 TLDS-KLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSE----AVMNQFENS 1207
D+ +L Q T ++S +++ KN L+ E+ E + E A+ +Q ++
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 1208 MRRVKEDTAAHIASL-----------KASHQREIEKLLCQNAVENSSSKVAELNRKIATQ 1256
++V +D I SL +A QR EK L + +E + ++ L +++
Sbjct: 1377 KKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR---LQQELDDL 1432
Query: 1257 EVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELR-EAKENHTPEMKHFVGL 1315
V + H + + L+ KQ+ E+ + + + EA+E T + L
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 1316 EKKI---KQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTE 1372
E+ + ++ E ++ Q +++ ++ V + E+EK KR + +++E+ RT+
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH--ELEKSKRALE---QQVEEMRTQ 1547
Query: 1373 LDSILDVLR 1381
L+ + D L+
Sbjct: 1548 LEELEDELQ 1556
Score = 108 bits (269), Expect = 5e-23
Identities = 210/1143 (18%), Positives = 471/1143 (41%), Gaps = 123/1143 (10%)
Query: 224 ISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDK----ITPKPRCLPEMTENEMTGTG 279
+ V +QEEE ++ + + E L+E ++ + + L E + E T
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE-TELF 903
Query: 280 VSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTV-EDIKSSVKGHPQENEENSKNIS 338
+ + + A Q I H L +++ E N + ++ K ++ H Q+ EE
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 339 TMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQD 398
L +E++ +I L+ +S+ + E+K E + + + ++
Sbjct: 964 GARQKLQ-LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME---DRIAECSSQLAEEE 1019
Query: 399 SQHVNLFFDKNDENVIL---------QKTTNESMENSCPQVT--------EVTATEEHVD 441
+ NL +N + V++ ++ T + +E + ++ ++ + +D
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 442 KMYLNILRKKITVNSSSLSQDDK-INKTYRSQLSSEEEGAVMGKQVPY---KKARSAPPL 497
++ L + +K+ + + DD+ ++K ++ E + + Q + K +R+
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 498 LKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEIL 557
KR L A ++ + L K +++ + K T N + + +
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQ--ELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 558 SGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDS----CIQFQTDSLGYCGENKEKKL 613
L + + + + +K++ ETD+ C + E+K KKL
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 614 LMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQ 673
+VQE K L ++ S+ + EL+N + L ++ EK+ K +D L+
Sbjct: 1258 --DAQVQELHAKVSEGDRLRVELAEKASKLQNELDN-VSTLLEEAEKKGIKFAKDAASLE 1314
Query: 674 AKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK--EIQEQETLLQGYQQENER----L 727
++L +E +++ T +KL + +++E++ LQ Q+E E L
Sbjct: 1315 SQLQDTQELLQEE------------TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 728 YNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDL 787
QV LQ Q ++++ + ++ S + K+ + + LSQ +E+ + L
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA----YDKL 1418
Query: 788 LAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKIL 847
Q+E D L D+ +Q + + EK +K+ DQ + EK +
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQ----VASNLEKKQKKFDQL------LAEEKSISARYA 1468
Query: 848 EETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEK-LKLEIEKLKAESGNPSIR 906
EE + E +K + + + L ++AL +E E K L+ ++E L + +
Sbjct: 1469 EERDRAEAEAREKETKALSLARAL--EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 907 QKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFME 966
K K A ++++++ Q++E+E L+ A A ++ N M+
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQ------------ATEDAKLRLEVN----MQ 1570
Query: 967 KRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKA 1026
+ E DL+ +DE ++ R + +Q ++++ + E +Q+ +A K +K
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID--LKD 1628
Query: 1027 LEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAK 1086
LE +++ +A ++ L +K EL+ + +D+ QS E + + +A+
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Query: 1087 LVRLNEELAAKKREIQDLSKTVERLQK-------------DRRMMLSNQNSKGREEMSAK 1133
+++L EELA+ +R + + + L D + L + ++ EE+ +
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 1134 RAKKDVLHSSKGNANSFPGTLDSKLYQPHTF---TDSHVSEVLQENYRLK---NELEGLI 1187
++ ++L+ TL+++L + +D+ ++ ++N LK ELEG +
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 1188 SEKNELKMKS-EAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKV 1246
K + + + EA + Q E + + ++ AA L +++++++ Q VE+
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAA-ANKLVRRTEKKLKEIFMQ--VEDERRHA 1865
Query: 1247 AELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHT 1306
+ ++ ++ + Q+ E + + R ++++ + L++ EA E +
Sbjct: 1866 DQYKEQMEKANARMKQLKRQLEEAEEE-------ATRANASRRKLQRELDDATEANEGLS 1918
Query: 1307 PEM 1309
E+
Sbjct: 1919 REV 1921
Score = 106 bits (264), Expect = 2e-22
Identities = 230/1165 (19%), Positives = 471/1165 (40%), Gaps = 145/1165 (12%)
Query: 55 KDDGLLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELN 114
+++ L + LK K+ V EE K Q L L ET +E
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 115 HSSLGVGLDTLEE-----------QEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHF 163
+ L LEE +EE+ Q +K + + I L ++LD +
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ--DLEEQLDEEEGARQ 967
Query: 164 KALHSNQANAE-----------LTDDEHENESKHEELAEN--------YSDDFEDEYVGA 204
K L + AE L +D++ K ++L E+ +++ E A
Sbjct: 968 K-LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 205 PLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKP 264
+ K E M S + +K +QE EK + D D +AE+ + D++ +
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA-QIDELKLQL 1085
Query: 265 RCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVK 324
E + + ++ ++ + + IA D + +K N E K +
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 325 GHPQENE---ENSKNISTMESDLPT-----VEELMKPIRIDSFGISG-----FDLQPVSS 371
+ + E++ + + + +L T V EL K + ++ +
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205
Query: 372 EKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNES---MENSCP 428
E+++E+ E L+ N L D++ + E +LQ+ ES +
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELAC------EVKVLQQVKAESEHKRKKLDA 1259
Query: 429 QVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPY 488
QV E+ A D++ + + K + + + + + + + ++ A + Q+
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL-- 1317
Query: 489 KKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTS 548
+ LL+ + + L S R + + L+ E++ +++ K +
Sbjct: 1318 ---QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 549 NQPRKKEILSGT---------KLIKPA-ALDKPAHKTESCLSTRKKSENPTETD-SCIQF 597
+ +K + GT KL+K A AL + + +K++N + + +
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 598 QTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKE-----LENKLE 652
D N EKK F ++ AE+K A+ E+ +A +EKE L LE
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLL-AEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 653 ELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQE 712
E + +E+ + Q ++ +SS ++ K +H E + +++++++ +++E
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKN---VHELEKSKRALEQQVEEMRTQLEE 1550
Query: 713 QETLLQGYQQENERLYNQV--------KDLQEQNKKNEERMFKENQSLFSEVASLKEQMH 764
E LQ + RL + +DLQ ++++NEE+ + L +V L+ ++
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK----KRLLIKQVRELEAELE 1606
Query: 765 KSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKK 824
R + S+ + DL A++ A K +D +++ +++L QA D+++ +
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL----QAQMKDYQRELE 1662
Query: 825 ERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANE 884
E ++D+I + E ++K LE EI +LQ +EL + R R A +
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLE----AEILQLQ---------EELASSERAR-RHAEQ 1708
Query: 885 EIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRY----- 939
E ++L EI A + + +K RL+ + A + ++LE + ME +L R+
Sbjct: 1709 ERDELADEITN-SASGKSALLDEKRRLEARIAQLE--EELEEEQSNME-LLNDRFRKTTL 1764
Query: 940 -PNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMK 998
++L A + A +A D N + +E++ K+L+A L+ + K + +
Sbjct: 1765 QVDTLNAELAAERSAAQKSD-NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 999 IQYEQRLEQQ--EQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQN 1056
Q E++LEQ+ E+ A KL + ++K + +++D + ++
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED-------------------ERRH 1864
Query: 1057 AELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR 1116
A+ ++ +K + + ++ Q+E+A +A R N +RE+ D ++ E L ++
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEA--TRANASRRKLQRELDDATEANEGLSREVS 1922
Query: 1117 MMLSNQNSKGREEMSAKRAKKDVLH 1141
+ + G S+ R+ + LH
Sbjct: 1923 TLKNRLRRGGPISFSSSRSGRRQLH 1947
Score = 92.4 bits (228), Expect = 3e-18
Identities = 193/998 (19%), Positives = 411/998 (41%), Gaps = 169/998 (16%)
Query: 6 QEELDEEFEQFMKELSDDSFENSDKTAR------QSKKEMKKKDTVPWWITEDDFK---- 55
+E+ +E E+ ++L ++ + D+ A + K ++ KK E++ +
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK--------EEELQGALA 1097
Query: 56 --DDGLLGTNVSYLKTKKTSQPVMEIEEE-SAEKIQFLKSSGTSLLSTDSLETNELVVSE 112
DD L N + ++ + E++E+ +EK K+ D E E + +E
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK---RDLSEELEALKTE 1154
Query: 113 LNHSSLGVGLDTLEEQEE----KEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHS 168
L + LDT Q+E +EQ A L+K L +E N + +
Sbjct: 1155 LEDT-----LDTTAAQQELRTKREQEVAELKKAL----------EEETKNHEAQIQDMRQ 1199
Query: 169 NQANAELTDDEHENESKHEELAENYSDDFEDEYVGAPLTTKD--------EEMPSKENSK 220
A A E S+ E A+ + + E G K+ +++ ++ K
Sbjct: 1200 RHATAL------EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253
Query: 221 SEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGV 280
+K+ QE + + ++ + +++ +E D ++ L E E + G+
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ-NELDNVST----LLEEAEKK----GI 1304
Query: 281 SYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNT----VEDIKSSVKGHPQENEENSKN 336
+ + ++ +E+ Q + L +E +QK+ ++ +E+ K+S++ +E EE KN
Sbjct: 1305 KFAKDAASLESQLQDTQEL---LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 337 IS----TMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNP 392
+ ++S L ++ ++D DL + S + A++K L +
Sbjct: 1362 LEKQVLALQSQLADTKK-----KVDD------DLGTIESLEEAKKK---------LLKDA 1401
Query: 393 NILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKI 452
LSQ + L +DK L+KT N + ++ ++T +H ++ N L KK
Sbjct: 1402 EALSQRLEEKALAYDK------LEKTKNRLQQ----ELDDLTVDLDHQRQVASN-LEKKQ 1450
Query: 453 TVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRS 512
L+++ I+ Y + E A + AR+ L+ K +
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE--------- 1501
Query: 513 SGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPA 572
+ + + L+ + +D+ KN+ + S + ++++ ++ L+
Sbjct: 1502 --FERQNKQLRADMEDLMSSKDDV--GKNVHELEKSKRALEQQVEEMRTQLEE--LEDEL 1555
Query: 573 HKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAE---DKWRGA 629
TE + + + QF+ D +N+EKK L+ K+V+E E + R
Sbjct: 1556 QATEDAKLRLEVNMQAMKA----QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 630 QALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWL 689
+AL K K+LE ++E K +++ + +L + LQA++ ++ ++ R
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK----LQAQMKDYQRELEEARAS 1667
Query: 690 HFGEAADPVTGEK--------LKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKN 741
A EK + Q+Q+E+ E + +QE + L +++ + +
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN----SASG 1723
Query: 742 EERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAEL---RMAQKEK 798
+ + E + L + +A L+E++ + + +++ D L AEL R A ++
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 799 DSLLEDIKRLKQDKQALEVDFEKMKKER------------DQAKDQIAYVTGEKLYEIKI 846
D+ + ++R ++ +A + E K + Q ++Q+ E+ K+
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Query: 847 LEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES--GNPS 904
+ T K +L++ + + D+ ++ +AN +++LK ++E+ + E+ N S
Sbjct: 1844 VRRTEK----KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 905 IRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNS 942
R+ R D A +A + L R+V ++ L+R P S
Sbjct: 1900 RRKLQRELDDATEAN--EGLSREVSTLKNRLRRGGPIS 1935
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 117 bits (294), Expect = 6e-26
Identities = 221/1119 (19%), Positives = 472/1119 (42%), Gaps = 115/1119 (10%)
Query: 272 ENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDK----QKIESNT-----VEDIKSS 322
E+E+ T ++ ++++ L Q HS E+K +++++ T E+++
Sbjct: 858 EDELQKTKERQQKAENELKELEQK-----HSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 323 VKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISG--FDLQPVSSEKVAERKET 380
+ QE EE + ME+ L E+ + ++ + ++ DL+ E+ A R++
Sbjct: 913 LAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 381 EF----FSSLPLKMNPNILSQDSQHVNLFFDKND-ENVILQKTTNESMENSCPQVTEVTA 435
+ + K+ IL D Q+ L ++ E I TTN + E + +T
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE--KAKNLTK 1027
Query: 436 TEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSS-EEEGAVMGKQVPYKKARSA 494
+ + M ++ L ++ S + +K+ + S E+ A + Q+ K +
Sbjct: 1028 LKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-- 1084
Query: 495 PPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS---EDIIKSKNLRSISTSNQP 551
L K++ + + + ++ LK LE S ED+ + R+ + +
Sbjct: 1085 --LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSL-GYCGENKE 610
E L K LD A + E K+ + T + +T S E ++
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQEL---RAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL---KKQQEKELFKLNQ 667
K + + E ++++ A+A +++ K T ++ +L +L L K++ E + KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 668 DNYILQAKLSSFE----ETNKKQRWLHFGEAADPVTG-------------EKLKQIQKEI 710
LQ+K S E E N K L + VTG + + + ++
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 711 QEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKE---NQSLFSEVASLKEQMHKSR 767
Q+ + LLQ ++ + +++ L+E+ ++++ +E Q+L +++L Q+ S+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 768 -----FLSQV--VEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFE 820
F S V +E+ + + +L + D L + RL+Q+ L VD +
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 821 KMKK-----ERDQAK-DQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDK 874
++ E+ Q K DQ+ + EK K +E + E +K + + + L +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQL--LAEEKNISSKYADERDRAEAEAREKETKALSLARAL--E 1493
Query: 875 DALRLREANEEIEK-LKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEG 933
+AL +E E K LK E+E L + + K K A ++++++ Q++E+E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 934 ILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQ 993
L+ L + + G + E DL+ +DE ++ R +++Q
Sbjct: 1554 ELQATEDAKLRLEVNMQALKG----------------QFERDLQARDEQNEEKRRQLQRQ 1597
Query: 994 FQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLK 1053
+ + + E E++++ LA + +K LE + D + + ++ L +K
Sbjct: 1598 LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 1054 HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK 1113
EL+ + +D+ + E + + +A L++L E+LAA +R + E L +
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 1114 DRRMMLSNQNSKGREE--MSAKRAK-KDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS 1170
+ LS +N+ E+ + A+ A+ ++ L +GN + + Q ++ +
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 1171 E--VLQENYRLKNELEGLISE-KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQ 1227
E Q+N + +LE E +++L AV ++F++++ ++ A IA L+ +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE----AKIAQLEEQVE 1831
Query: 1228 REI-EKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE----LQSKQESLVVSEV 1282
+E EK +++ K+ E+ ++ + + ++ Q + ++ + L +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 1283 REEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQ 1321
+ + KL EL EA E++ + L+ K+++
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 117 bits (292), Expect = 1e-25
Identities = 177/856 (20%), Positives = 374/856 (43%), Gaps = 122/856 (14%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL------------ 654
+ K+ +LM K ++ + +R Q+ I + E+E + K+ ++
Sbjct: 742 DGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL 801
Query: 655 ------KKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK 708
K+QQ+ K+ Q N KL +++ W P+ ++ + ++
Sbjct: 802 ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ-------WWRLFTKVKPLL--QVTRQEE 852
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKK--NEERMFKENQSLFSEVASLKEQMHKS 766
E+Q +E LQ ++ ++ N++K+L++++ + E+ + +E +E+ + E+M
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 767 RFLSQVVEDSEPTRNQNFTDLLAEL--RMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKK 824
+ Q ++L E+ R+ ++E +R K +Q L+++ + ++
Sbjct: 913 L----------AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 825 ERDQAKDQIAYVTGE----KLYEIKILEETHKQEISR----LQKRLQWYAENQELLDKDA 876
E + K Q+ VT E KL + ++ + ++S+ L++R+ N ++ A
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 877 LRLREANEEIEKLKLEIE-KLKAESGNPSIRQKIRLK---DKAADAKKIQDLERQVKEME 932
L + + E + E+E +LK E + +K++ K D + ++I DL+ Q+ E++
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 933 GILKRRYPNSLPALILAASAAGDTVDKNT----VEFMEKRIKKLEADLEGK---DEDAKK 985
L ++ AL A + KN + +E I L+ DL+ + A+K
Sbjct: 1083 MQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 986 SLRTMEQQFQKMKIQYEQRLEQ--QEQLLACKLNQHDSPRIKALEKE-------LDDIKE 1036
R + ++ + +K + E L+ +Q L K Q + KAL++E + ++++
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 1037 AHQITVRNLEAEIDVLKHQNAELDVKKN--DKDDEDFQSIEFQV------EQAHAKAKLV 1088
H V L +++ K A LD K +K++ D E +V E H K KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG-ELRVLGQAKQEVEHKKKKLE 1258
Query: 1089 RLNEELAAK----KREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSK 1144
+EL +K +R +L+ V +LQ + + N E A + KDV S
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN---EAEGKAIKLAKDVASLSS 1315
Query: 1145 GNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSE---AVM 1201
++ +L Q T +VS L++ +N L+ + E+ E K E + +
Sbjct: 1316 QLQDT------QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 1202 NQFENSMRRVKEDTAAHIASL---KASHQREIEKLLCQNAVENSSSKVAELNRKIATQEV 1258
N + ++ +D A+ + +L K Q+EIE N + K A ++ T+
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-----NLTQQYEEKAAAYDKLEKTKNR 1424
Query: 1259 LIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPE--MKHFVGLE 1316
L + V +L ++++ +VS + ++ Q++ +LL E + + E E
Sbjct: 1425 LQQELDDLVVDLDNQRQ--LVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 1317 KKIKQMEMRHAQREQ-ELQQIIQQTHQVVETEQ----------NKEVEKWKRLAQLKNRE 1365
K+ K + + A E E ++ +++T+++++ E K V + ++ + +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1366 LEKFRTELDSILDVLR 1381
+E+ +T+L+ + D L+
Sbjct: 1541 MEEMKTQLEELEDELQ 1556
Score = 100 bits (248), Expect = 1e-20
Identities = 200/988 (20%), Positives = 413/988 (41%), Gaps = 112/988 (11%)
Query: 460 SQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSG--LYASVRSSGYGK 517
+++D++ KT Q +E E + ++ + + LL+ + Q+ LYA
Sbjct: 856 AKEDELQKTKERQQKAENELKELEQK--HSQLTEEKNLLQEQLQAETELYAEAEE----- 908
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
+++ +K+ E+I+ R + R +++ + K + LD E
Sbjct: 909 ----MRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 578 CLSTRKKSENPTETDSCIQFQTDSLGYCGE-----NKEKKLL------MFKRVQEAEDKW 626
+ +K ++ I+ D + + +KE+KLL + + E E+K
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 627 RGAQALIEQIKATFSE------KEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFE 680
+ L + ++ SE KE++ +LE+LK++ E + ++ LQA+++ +
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 681 -ETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ-- 737
+ KK+ L +AA L ++ EI ++ L+ ++ L + DLQE
Sbjct: 1083 MQLAKKEEEL---QAA-------LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLD 1128
Query: 738 -NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQK 796
+ + K+ + L E+ +LK ++ + + ++ R Q T L L +
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 797 EKDSLLEDIKRLKQDKQALEV------DFEKMKKERDQAKDQIAYVTGEKLYEIKILEET 850
++ ++++++ + QA+E F++ K D+ K + + E+++L +
Sbjct: 1189 SHEAQVQEMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 851 HKQEISRLQKRLQWYAENQELLDK--DALRLR-EANEEIEKLKLEIEKLKAESGNPSIRQ 907
KQE+ +K+L+ A+ QEL K D R R E N+++ KL+ E+E + +
Sbjct: 1247 -KQEVEHKKKKLE--AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 908 KIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN--TVEFM 965
KD A+ + ++QD + ++E E K L L ++ D +D+ + +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 966 EKRIKKLE---ADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLAC--KLNQHD 1020
E+ I L +D + K +D ++ +E+ ++ + + E +Q E+ A KL +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1021 SPRIKALEKELDDIK---EAHQITVRNLEAE---IDVLKHQNAELDVKKNDKDDE----- 1069
+ L++ELDD+ + + V NLE + D L + + K D+ D
Sbjct: 1423 N----RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 1070 -----DFQSIEFQVEQA-HAKAKLVRLNEELAAKKREI----QDLSKTVERLQKDRRMM- 1118
S+ +E+A AK +L R N+ L A+ ++ D+ K V L+K +R +
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 1119 --LSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
+ ++ E +A +D + N + G + L D E ++
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQL 1594
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ 1236
R +E E + ++ + + + A + E ++ ++ + I + + +++ KL Q
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI-KQLRKLQAQ 1653
Query: 1237 NAVENSSSKVAELNRK--IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKL 1294
+ A +R AT + + +S +L QE L +E + E +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 1295 LEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVV-ETEQNKEVE 1353
EEL + LE +I Q+E + + ++ + + + + EQ
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 1354 KWKRLAQLKN----RELEKFRTELDSIL 1377
+R KN ++LE+ EL S L
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKL 1801
Score = 95.5 bits (236), Expect = 3e-19
Identities = 147/697 (21%), Positives = 301/697 (43%), Gaps = 93/697 (13%)
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVED--SEPTRNQN 783
RL+ +VK L + ++ EE KE+ E+ KE+ K+ + +E S+ T +N
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKED-----ELQKTKERQQKAENELKELEQKHSQLTEEKN 890
Query: 784 FTDLLAELRMAQKEKDSLLEDIK-RLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLY 842
LL E A+ E + E+++ RL KQ LE +M+ ++ +D+ + E+
Sbjct: 891 ---LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER-- 945
Query: 843 EIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
+ Q++ L+++L+ +E + L+L + E + KLE E L + N
Sbjct: 946 ------KKMAQQMLDLEEQLE-----EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 903 PSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKN 960
+ ++ +L ++ +I DL + E E K + N ++I +K+
Sbjct: 995 NKLSKERKLLEE-----RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
E ++KL+ LEG D + + ++ Q ++K+Q ++ E+ + LA +L+
Sbjct: 1050 RQE-----LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA-RLDDEI 1103
Query: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
+ + AL+K + E H + +L+ ++D + + + +K D +E ++++ ++E
Sbjct: 1104 AQKNNALKKIRE--LEGH---ISDLQEDLDSERAARNKAEKQKRDLGEE-LEALKTELED 1157
Query: 1081 AHAKAKLVRLNEELAAKK-REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV 1139
+EL AK+ +E+ L K ++ + + K + + + +
Sbjct: 1158 T---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 1140 LHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEA 1199
+K N + TL+ +EN L EL L K E++ K +
Sbjct: 1215 FKRAKANLDKNKQTLE------------------KENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1200 VMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVL 1259
+ Q + + + A +A ++ KL QN VE+ + + E K L
Sbjct: 1257 LEAQVQELQSKCSDGERA-----RAELNDKVHKL--QNEVESVTGMLNEAEGKAIK---L 1306
Query: 1260 IRHFQSQVNELQSKQESLVVSEVREEI-LQKEITKLLEELREAKENHTPEMKHFVGLEKK 1318
+ S ++LQ QE L+ E R+++ + ++ +L EE ++ EM+ LE+
Sbjct: 1307 AKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 1319 IKQMEMRHAQREQELQQIIQQTHQVVETEQ--NKEVEK-----------WKRLAQLKNR- 1364
I + ++ + +++LQ + E ++ KE+E + +L + KNR
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 1365 --ELEKFRTELDSILDVLRELHRQGVVVPVAFADEMN 1399
EL+ +LD+ ++ L ++ A+E N
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 117 bits (294), Expect = 6e-26
Identities = 221/1119 (19%), Positives = 472/1119 (42%), Gaps = 115/1119 (10%)
Query: 272 ENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDK----QKIESNT-----VEDIKSS 322
E+E+ T ++ ++++ L Q HS E+K +++++ T E+++
Sbjct: 865 EDELQKTKERQQKAENELKELEQK-----HSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 323 VKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISG--FDLQPVSSEKVAERKET 380
+ QE EE + ME+ L E+ + ++ + ++ DL+ E+ A R++
Sbjct: 920 LAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 381 EF----FSSLPLKMNPNILSQDSQHVNLFFDKND-ENVILQKTTNESMENSCPQVTEVTA 435
+ + K+ IL D Q+ L ++ E I TTN + E + +T
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE--KAKNLTK 1034
Query: 436 TEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSS-EEEGAVMGKQVPYKKARSA 494
+ + M ++ L ++ S + +K+ + S E+ A + Q+ K +
Sbjct: 1035 LKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-- 1091
Query: 495 PPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS---EDIIKSKNLRSISTSNQP 551
L K++ + + + ++ LK LE S ED+ + R+ + +
Sbjct: 1092 --LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSL-GYCGENKE 610
E L K LD A + E K+ + T + +T S E ++
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQEL---RAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL---KKQQEKELFKLNQ 667
K + + E ++++ A+A +++ K T ++ +L +L L K++ E + KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 668 DNYILQAKLSSFE----ETNKKQRWLHFGEAADPVTG-------------EKLKQIQKEI 710
LQ+K S E E N K L + VTG + + + ++
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 711 QEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKE---NQSLFSEVASLKEQMHKSR 767
Q+ + LLQ ++ + +++ L+E+ ++++ +E Q+L +++L Q+ S+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 768 -----FLSQV--VEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFE 820
F S V +E+ + + +L + D L + RL+Q+ L VD +
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 821 KMKK-----ERDQAK-DQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDK 874
++ E+ Q K DQ+ + EK K +E + E +K + + + L +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQL--LAEEKNISSKYADERDRAEAEAREKETKALSLARAL--E 1500
Query: 875 DALRLREANEEIEK-LKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEG 933
+AL +E E K LK E+E L + + K K A ++++++ Q++E+E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 934 ILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQ 993
L+ L + + G + E DL+ +DE ++ R +++Q
Sbjct: 1561 ELQATEDAKLRLEVNMQALKG----------------QFERDLQARDEQNEEKRRQLQRQ 1604
Query: 994 FQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLK 1053
+ + + E E++++ LA + +K LE + D + + ++ L +K
Sbjct: 1605 LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 1054 HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK 1113
EL+ + +D+ + E + + +A L++L E+LAA +R + E L +
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 1114 DRRMMLSNQNSKGREE--MSAKRAK-KDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS 1170
+ LS +N+ E+ + A+ A+ ++ L +GN + + Q ++ +
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 1171 E--VLQENYRLKNELEGLISE-KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQ 1227
E Q+N + +LE E +++L AV ++F++++ ++ A IA L+ +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE----AKIAQLEEQVE 1838
Query: 1228 REI-EKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE----LQSKQESLVVSEV 1282
+E EK +++ K+ E+ ++ + + ++ Q + ++ + L +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 1283 REEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQ 1321
+ + KL EL EA E++ + L+ K+++
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 117 bits (292), Expect = 1e-25
Identities = 177/856 (20%), Positives = 374/856 (43%), Gaps = 122/856 (14%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL------------ 654
+ K+ +LM K ++ + +R Q+ I + E+E + K+ ++
Sbjct: 749 DGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL 808
Query: 655 ------KKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK 708
K+QQ+ K+ Q N KL +++ W P+ ++ + ++
Sbjct: 809 ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ-------WWRLFTKVKPLL--QVTRQEE 859
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKK--NEERMFKENQSLFSEVASLKEQMHKS 766
E+Q +E LQ ++ ++ N++K+L++++ + E+ + +E +E+ + E+M
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 767 RFLSQVVEDSEPTRNQNFTDLLAEL--RMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKK 824
+ Q ++L E+ R+ ++E +R K +Q L+++ + ++
Sbjct: 920 L----------AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 825 ERDQAKDQIAYVTGE----KLYEIKILEETHKQEISR----LQKRLQWYAENQELLDKDA 876
E + K Q+ VT E KL + ++ + ++S+ L++R+ N ++ A
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 877 LRLREANEEIEKLKLEIE-KLKAESGNPSIRQKIRLK---DKAADAKKIQDLERQVKEME 932
L + + E + E+E +LK E + +K++ K D + ++I DL+ Q+ E++
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 933 GILKRRYPNSLPALILAASAAGDTVDKNT----VEFMEKRIKKLEADLEGK---DEDAKK 985
L ++ AL A + KN + +E I L+ DL+ + A+K
Sbjct: 1090 MQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 986 SLRTMEQQFQKMKIQYEQRLEQ--QEQLLACKLNQHDSPRIKALEKE-------LDDIKE 1036
R + ++ + +K + E L+ +Q L K Q + KAL++E + ++++
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 1037 AHQITVRNLEAEIDVLKHQNAELDVKKN--DKDDEDFQSIEFQV------EQAHAKAKLV 1088
H V L +++ K A LD K +K++ D E +V E H K KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG-ELRVLGQAKQEVEHKKKKLE 1265
Query: 1089 RLNEELAAK----KREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSK 1144
+EL +K +R +L+ V +LQ + + N E A + KDV S
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN---EAEGKAIKLAKDVASLSS 1322
Query: 1145 GNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSE---AVM 1201
++ +L Q T +VS L++ +N L+ + E+ E K E + +
Sbjct: 1323 QLQDT------QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 1202 NQFENSMRRVKEDTAAHIASL---KASHQREIEKLLCQNAVENSSSKVAELNRKIATQEV 1258
N + ++ +D A+ + +L K Q+EIE N + K A ++ T+
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-----NLTQQYEEKAAAYDKLEKTKNR 1431
Query: 1259 LIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPE--MKHFVGLE 1316
L + V +L ++++ +VS + ++ Q++ +LL E + + E E
Sbjct: 1432 LQQELDDLVVDLDNQRQ--LVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 1317 KKIKQMEMRHAQREQ-ELQQIIQQTHQVVETEQ----------NKEVEKWKRLAQLKNRE 1365
K+ K + + A E E ++ +++T+++++ E K V + ++ + +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1366 LEKFRTELDSILDVLR 1381
+E+ +T+L+ + D L+
Sbjct: 1548 MEEMKTQLEELEDELQ 1563
Score = 100 bits (248), Expect = 1e-20
Identities = 200/988 (20%), Positives = 413/988 (41%), Gaps = 112/988 (11%)
Query: 460 SQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSG--LYASVRSSGYGK 517
+++D++ KT Q +E E + ++ + + LL+ + Q+ LYA
Sbjct: 863 AKEDELQKTKERQQKAENELKELEQK--HSQLTEEKNLLQEQLQAETELYAEAEE----- 915
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
+++ +K+ E+I+ R + R +++ + K + LD E
Sbjct: 916 ----MRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 578 CLSTRKKSENPTETDSCIQFQTDSLGYCGE-----NKEKKLL------MFKRVQEAEDKW 626
+ +K ++ I+ D + + +KE+KLL + + E E+K
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 627 RGAQALIEQIKATFSE------KEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFE 680
+ L + ++ SE KE++ +LE+LK++ E + ++ LQA+++ +
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 681 -ETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ-- 737
+ KK+ L +AA L ++ EI ++ L+ ++ L + DLQE
Sbjct: 1090 MQLAKKEEEL---QAA-------LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLD 1135
Query: 738 -NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQK 796
+ + K+ + L E+ +LK ++ + + ++ R Q T L L +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 797 EKDSLLEDIKRLKQDKQALEV------DFEKMKKERDQAKDQIAYVTGEKLYEIKILEET 850
++ ++++++ + QA+E F++ K D+ K + + E+++L +
Sbjct: 1196 SHEAQVQEMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 851 HKQEISRLQKRLQWYAENQELLDK--DALRLR-EANEEIEKLKLEIEKLKAESGNPSIRQ 907
KQE+ +K+L+ A+ QEL K D R R E N+++ KL+ E+E + +
Sbjct: 1254 -KQEVEHKKKKLE--AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 908 KIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN--TVEFM 965
KD A+ + ++QD + ++E E K L L ++ D +D+ + +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 966 EKRIKKLE---ADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLAC--KLNQHD 1020
E+ I L +D + K +D ++ +E+ ++ + + E +Q E+ A KL +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1021 SPRIKALEKELDDIK---EAHQITVRNLEAE---IDVLKHQNAELDVKKNDKDDE----- 1069
+ L++ELDD+ + + V NLE + D L + + K D+ D
Sbjct: 1430 N----RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 1070 -----DFQSIEFQVEQA-HAKAKLVRLNEELAAKKREI----QDLSKTVERLQKDRRMM- 1118
S+ +E+A AK +L R N+ L A+ ++ D+ K V L+K +R +
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 1119 --LSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
+ ++ E +A +D + N + G + L D E ++
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQL 1601
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ 1236
R +E E + ++ + + + A + E ++ ++ + I + + +++ KL Q
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI-KQLRKLQAQ 1660
Query: 1237 NAVENSSSKVAELNRK--IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKL 1294
+ A +R AT + + +S +L QE L +E + E +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 1295 LEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVV-ETEQNKEVE 1353
EEL + LE +I Q+E + + ++ + + + + EQ
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 1354 KWKRLAQLKN----RELEKFRTELDSIL 1377
+R KN ++LE+ EL S L
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKL 1808
Score = 95.5 bits (236), Expect = 3e-19
Identities = 147/697 (21%), Positives = 301/697 (43%), Gaps = 93/697 (13%)
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVED--SEPTRNQN 783
RL+ +VK L + ++ EE KE+ E+ KE+ K+ + +E S+ T +N
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKED-----ELQKTKERQQKAENELKELEQKHSQLTEEKN 897
Query: 784 FTDLLAELRMAQKEKDSLLEDIK-RLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLY 842
LL E A+ E + E+++ RL KQ LE +M+ ++ +D+ + E+
Sbjct: 898 ---LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER-- 952
Query: 843 EIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
+ Q++ L+++L+ +E + L+L + E + KLE E L + N
Sbjct: 953 ------KKMAQQMLDLEEQLE-----EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 903 PSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKN 960
+ ++ +L ++ +I DL + E E K + N ++I +K+
Sbjct: 1002 NKLSKERKLLEE-----RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
E ++KL+ LEG D + + ++ Q ++K+Q ++ E+ + LA +L+
Sbjct: 1057 RQE-----LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA-RLDDEI 1110
Query: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
+ + AL+K + E H + +L+ ++D + + + +K D +E ++++ ++E
Sbjct: 1111 AQKNNALKKIRE--LEGH---ISDLQEDLDSERAARNKAEKQKRDLGEE-LEALKTELED 1164
Query: 1081 AHAKAKLVRLNEELAAKK-REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV 1139
+EL AK+ +E+ L K ++ + + K + + + +
Sbjct: 1165 T---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 1140 LHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEA 1199
+K N + TL+ +EN L EL L K E++ K +
Sbjct: 1222 FKRAKANLDKNKQTLE------------------KENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1200 VMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVL 1259
+ Q + + + A +A ++ KL QN VE+ + + E K L
Sbjct: 1264 LEAQVQELQSKCSDGERA-----RAELNDKVHKL--QNEVESVTGMLNEAEGKAIK---L 1313
Query: 1260 IRHFQSQVNELQSKQESLVVSEVREEI-LQKEITKLLEELREAKENHTPEMKHFVGLEKK 1318
+ S ++LQ QE L+ E R+++ + ++ +L EE ++ EM+ LE+
Sbjct: 1314 AKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 1319 IKQMEMRHAQREQELQQIIQQTHQVVETEQ--NKEVEK-----------WKRLAQLKNR- 1364
I + ++ + +++LQ + E ++ KE+E + +L + KNR
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 1365 --ELEKFRTELDSILDVLRELHRQGVVVPVAFADEMN 1399
EL+ +LD+ ++ L ++ A+E N
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 117 bits (293), Expect = 8e-26
Identities = 221/1118 (19%), Positives = 471/1118 (42%), Gaps = 115/1118 (10%)
Query: 272 ENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDK----QKIESNT-----VEDIKSS 322
E+E+ T ++ ++++ L Q HS E+K +++++ T E+++
Sbjct: 865 EDELQKTKERQQKAENELKELEQK-----HSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 323 VKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISG--FDLQPVSSEKVAERKET 380
+ QE EE + ME+ L E+ + ++ + ++ DL+ E+ A R++
Sbjct: 920 LAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 381 EF----FSSLPLKMNPNILSQDSQHVNLFFDKND-ENVILQKTTNESMENSCPQVTEVTA 435
+ + K+ IL D Q+ L ++ E I TTN + E + +T
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE--KAKNLTK 1034
Query: 436 TEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSS-EEEGAVMGKQVPYKKARSA 494
+ + M ++ L ++ S + +K+ + S E+ A + Q+ K +
Sbjct: 1035 LKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-- 1091
Query: 495 PPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS---EDIIKSKNLRSISTSNQP 551
L K++ + + + ++ LK LE S ED+ + R+ + +
Sbjct: 1092 --LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSL-GYCGENKE 610
E L K LD A + E K+ + T + +T S E ++
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQEL---RAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL---KKQQEKELFKLNQ 667
K + + E ++++ A+A +++ K T ++ +L +L L K++ E + KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 668 DNYILQAKLSSFE----ETNKKQRWLHFGEAADPVTG-------------EKLKQIQKEI 710
LQ+K S E E N K L + VTG + + + ++
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 711 QEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKE---NQSLFSEVASLKEQMHKSR 767
Q+ + LLQ ++ + +++ L+E+ ++++ +E Q+L +++L Q+ S+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 768 -----FLSQV--VEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFE 820
F S V +E+ + + +L + D L + RL+Q+ L VD +
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 821 KMKK-----ERDQAK-DQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDK 874
++ E+ Q K DQ+ + EK K +E + E +K + + + L +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQL--LAEEKNISSKYADERDRAEAEAREKETKALSLARAL--E 1500
Query: 875 DALRLREANEEIEK-LKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEG 933
+AL +E E K LK E+E L + + K K A ++++++ Q++E+E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 934 ILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQ 993
L+ L + + G + E DL+ +DE ++ R +++Q
Sbjct: 1561 ELQATEDAKLRLEVNMQALKG----------------QFERDLQARDEQNEEKRRQLQRQ 1604
Query: 994 FQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLK 1053
+ + + E E++++ LA + +K LE + D + + ++ L +K
Sbjct: 1605 LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 1054 HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK 1113
EL+ + +D+ + E + + +A L++L E+LAA +R + E L +
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 1114 DRRMMLSNQNSKGREE--MSAKRAK-KDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS 1170
+ LS +N+ E+ + A+ A+ ++ L +GN + + Q ++ +
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 1171 E--VLQENYRLKNELEGLISE-KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQ 1227
E Q+N + +LE E +++L AV ++F++++ ++ A IA L+ +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE----AKIAQLEEQVE 1838
Query: 1228 REI-EKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE----LQSKQESLVVSEV 1282
+E EK +++ K+ E+ ++ + + ++ Q + ++ + L +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 1283 REEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK 1320
+ + KL EL EA E++ + L+ K++
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 117 bits (292), Expect = 1e-25
Identities = 177/856 (20%), Positives = 374/856 (43%), Gaps = 122/856 (14%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL------------ 654
+ K+ +LM K ++ + +R Q+ I + E+E + K+ ++
Sbjct: 749 DGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL 808
Query: 655 ------KKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK 708
K+QQ+ K+ Q N KL +++ W P+ ++ + ++
Sbjct: 809 ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ-------WWRLFTKVKPLL--QVTRQEE 859
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKK--NEERMFKENQSLFSEVASLKEQMHKS 766
E+Q +E LQ ++ ++ N++K+L++++ + E+ + +E +E+ + E+M
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 767 RFLSQVVEDSEPTRNQNFTDLLAEL--RMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKK 824
+ Q ++L E+ R+ ++E +R K +Q L+++ + ++
Sbjct: 920 L----------AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 825 ERDQAKDQIAYVTGE----KLYEIKILEETHKQEISR----LQKRLQWYAENQELLDKDA 876
E + K Q+ VT E KL + ++ + ++S+ L++R+ N ++ A
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 877 LRLREANEEIEKLKLEIE-KLKAESGNPSIRQKIRLK---DKAADAKKIQDLERQVKEME 932
L + + E + E+E +LK E + +K++ K D + ++I DL+ Q+ E++
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 933 GILKRRYPNSLPALILAASAAGDTVDKNT----VEFMEKRIKKLEADLEGK---DEDAKK 985
L ++ AL A + KN + +E I L+ DL+ + A+K
Sbjct: 1090 MQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 986 SLRTMEQQFQKMKIQYEQRLEQ--QEQLLACKLNQHDSPRIKALEKE-------LDDIKE 1036
R + ++ + +K + E L+ +Q L K Q + KAL++E + ++++
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 1037 AHQITVRNLEAEIDVLKHQNAELDVKKN--DKDDEDFQSIEFQV------EQAHAKAKLV 1088
H V L +++ K A LD K +K++ D E +V E H K KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG-ELRVLGQAKQEVEHKKKKLE 1265
Query: 1089 RLNEELAAK----KREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSK 1144
+EL +K +R +L+ V +LQ + + N E A + KDV S
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN---EAEGKAIKLAKDVASLSS 1322
Query: 1145 GNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSE---AVM 1201
++ +L Q T +VS L++ +N L+ + E+ E K E + +
Sbjct: 1323 QLQDT------QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 1202 NQFENSMRRVKEDTAAHIASL---KASHQREIEKLLCQNAVENSSSKVAELNRKIATQEV 1258
N + ++ +D A+ + +L K Q+EIE N + K A ++ T+
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-----NLTQQYEEKAAAYDKLEKTKNR 1431
Query: 1259 LIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPE--MKHFVGLE 1316
L + V +L ++++ +VS + ++ Q++ +LL E + + E E
Sbjct: 1432 LQQELDDLVVDLDNQRQ--LVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 1317 KKIKQMEMRHAQREQ-ELQQIIQQTHQVVETEQ----------NKEVEKWKRLAQLKNRE 1365
K+ K + + A E E ++ +++T+++++ E K V + ++ + +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1366 LEKFRTELDSILDVLR 1381
+E+ +T+L+ + D L+
Sbjct: 1548 MEEMKTQLEELEDELQ 1563
Score = 100 bits (248), Expect = 1e-20
Identities = 200/988 (20%), Positives = 413/988 (41%), Gaps = 112/988 (11%)
Query: 460 SQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSG--LYASVRSSGYGK 517
+++D++ KT Q +E E + ++ + + LL+ + Q+ LYA
Sbjct: 863 AKEDELQKTKERQQKAENELKELEQK--HSQLTEEKNLLQEQLQAETELYAEAEE----- 915
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
+++ +K+ E+I+ R + R +++ + K + LD E
Sbjct: 916 ----MRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 578 CLSTRKKSENPTETDSCIQFQTDSLGYCGE-----NKEKKLL------MFKRVQEAEDKW 626
+ +K ++ I+ D + + +KE+KLL + + E E+K
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 627 RGAQALIEQIKATFSE------KEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFE 680
+ L + ++ SE KE++ +LE+LK++ E + ++ LQA+++ +
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 681 -ETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ-- 737
+ KK+ L +AA L ++ EI ++ L+ ++ L + DLQE
Sbjct: 1090 MQLAKKEEEL---QAA-------LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLD 1135
Query: 738 -NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQK 796
+ + K+ + L E+ +LK ++ + + ++ R Q T L L +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 797 EKDSLLEDIKRLKQDKQALEV------DFEKMKKERDQAKDQIAYVTGEKLYEIKILEET 850
++ ++++++ + QA+E F++ K D+ K + + E+++L +
Sbjct: 1196 SHEAQVQEMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 851 HKQEISRLQKRLQWYAENQELLDK--DALRLR-EANEEIEKLKLEIEKLKAESGNPSIRQ 907
KQE+ +K+L+ A+ QEL K D R R E N+++ KL+ E+E + +
Sbjct: 1254 -KQEVEHKKKKLE--AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 908 KIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN--TVEFM 965
KD A+ + ++QD + ++E E K L L ++ D +D+ + +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 966 EKRIKKLE---ADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLAC--KLNQHD 1020
E+ I L +D + K +D ++ +E+ ++ + + E +Q E+ A KL +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1021 SPRIKALEKELDDIK---EAHQITVRNLEAE---IDVLKHQNAELDVKKNDKDDE----- 1069
+ L++ELDD+ + + V NLE + D L + + K D+ D
Sbjct: 1430 N----RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 1070 -----DFQSIEFQVEQA-HAKAKLVRLNEELAAKKREI----QDLSKTVERLQKDRRMM- 1118
S+ +E+A AK +L R N+ L A+ ++ D+ K V L+K +R +
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 1119 --LSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
+ ++ E +A +D + N + G + L D E ++
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQL 1601
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ 1236
R +E E + ++ + + + A + E ++ ++ + I + + +++ KL Q
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI-KQLRKLQAQ 1660
Query: 1237 NAVENSSSKVAELNRK--IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKL 1294
+ A +R AT + + +S +L QE L +E + E +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 1295 LEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVV-ETEQNKEVE 1353
EEL + LE +I Q+E + + ++ + + + + EQ
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 1354 KWKRLAQLKN----RELEKFRTELDSIL 1377
+R KN ++LE+ EL S L
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKL 1808
Score = 95.5 bits (236), Expect = 3e-19
Identities = 147/697 (21%), Positives = 301/697 (43%), Gaps = 93/697 (13%)
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVED--SEPTRNQN 783
RL+ +VK L + ++ EE KE+ E+ KE+ K+ + +E S+ T +N
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKED-----ELQKTKERQQKAENELKELEQKHSQLTEEKN 897
Query: 784 FTDLLAELRMAQKEKDSLLEDIK-RLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLY 842
LL E A+ E + E+++ RL KQ LE +M+ ++ +D+ + E+
Sbjct: 898 ---LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER-- 952
Query: 843 EIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
+ Q++ L+++L+ +E + L+L + E + KLE E L + N
Sbjct: 953 ------KKMAQQMLDLEEQLE-----EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 903 PSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKN 960
+ ++ +L ++ +I DL + E E K + N ++I +K+
Sbjct: 1002 NKLSKERKLLEE-----RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
E ++KL+ LEG D + + ++ Q ++K+Q ++ E+ + LA +L+
Sbjct: 1057 RQE-----LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA-RLDDEI 1110
Query: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
+ + AL+K + E H + +L+ ++D + + + +K D +E ++++ ++E
Sbjct: 1111 AQKNNALKKIRE--LEGH---ISDLQEDLDSERAARNKAEKQKRDLGEE-LEALKTELED 1164
Query: 1081 AHAKAKLVRLNEELAAKK-REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV 1139
+EL AK+ +E+ L K ++ + + K + + + +
Sbjct: 1165 T---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 1140 LHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEA 1199
+K N + TL+ +EN L EL L K E++ K +
Sbjct: 1222 FKRAKANLDKNKQTLE------------------KENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1200 VMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVL 1259
+ Q + + + A +A ++ KL QN VE+ + + E K L
Sbjct: 1264 LEAQVQELQSKCSDGERA-----RAELNDKVHKL--QNEVESVTGMLNEAEGKAIK---L 1313
Query: 1260 IRHFQSQVNELQSKQESLVVSEVREEI-LQKEITKLLEELREAKENHTPEMKHFVGLEKK 1318
+ S ++LQ QE L+ E R+++ + ++ +L EE ++ EM+ LE+
Sbjct: 1314 AKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 1319 IKQMEMRHAQREQELQQIIQQTHQVVETEQ--NKEVEK-----------WKRLAQLKNR- 1364
I + ++ + +++LQ + E ++ KE+E + +L + KNR
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 1365 --ELEKFRTELDSILDVLRELHRQGVVVPVAFADEMN 1399
EL+ +LD+ ++ L ++ A+E N
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 117 bits (293), Expect = 8e-26
Identities = 221/1118 (19%), Positives = 471/1118 (42%), Gaps = 115/1118 (10%)
Query: 272 ENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDK----QKIESNT-----VEDIKSS 322
E+E+ T ++ ++++ L Q HS E+K +++++ T E+++
Sbjct: 858 EDELQKTKERQQKAENELKELEQK-----HSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 323 VKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISG--FDLQPVSSEKVAERKET 380
+ QE EE + ME+ L E+ + ++ + ++ DL+ E+ A R++
Sbjct: 913 LAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 381 EF----FSSLPLKMNPNILSQDSQHVNLFFDKND-ENVILQKTTNESMENSCPQVTEVTA 435
+ + K+ IL D Q+ L ++ E I TTN + E + +T
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE--KAKNLTK 1027
Query: 436 TEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSS-EEEGAVMGKQVPYKKARSA 494
+ + M ++ L ++ S + +K+ + S E+ A + Q+ K +
Sbjct: 1028 LKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-- 1084
Query: 495 PPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS---EDIIKSKNLRSISTSNQP 551
L K++ + + + ++ LK LE S ED+ + R+ + +
Sbjct: 1085 --LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 552 RKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSL-GYCGENKE 610
E L K LD A + E K+ + T + +T S E ++
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQEL---RAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 611 KKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL---KKQQEKELFKLNQ 667
K + + E ++++ A+A +++ K T ++ +L +L L K++ E + KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 668 DNYILQAKLSSFE----ETNKKQRWLHFGEAADPVTG-------------EKLKQIQKEI 710
LQ+K S E E N K L + VTG + + + ++
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 711 QEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKE---NQSLFSEVASLKEQMHKSR 767
Q+ + LLQ ++ + +++ L+E+ ++++ +E Q+L +++L Q+ S+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 768 -----FLSQV--VEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFE 820
F S V +E+ + + +L + D L + RL+Q+ L VD +
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 821 KMKK-----ERDQAK-DQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDK 874
++ E+ Q K DQ+ + EK K +E + E +K + + + L +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQL--LAEEKNISSKYADERDRAEAEAREKETKALSLARAL--E 1493
Query: 875 DALRLREANEEIEK-LKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEG 933
+AL +E E K LK E+E L + + K K A ++++++ Q++E+E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 934 ILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQ 993
L+ L + + G + E DL+ +DE ++ R +++Q
Sbjct: 1554 ELQATEDAKLRLEVNMQALKG----------------QFERDLQARDEQNEEKRRQLQRQ 1597
Query: 994 FQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLK 1053
+ + + E E++++ LA + +K LE + D + + ++ L +K
Sbjct: 1598 LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 1054 HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK 1113
EL+ + +D+ + E + + +A L++L E+LAA +R + E L +
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 1114 DRRMMLSNQNSKGREE--MSAKRAK-KDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS 1170
+ LS +N+ E+ + A+ A+ ++ L +GN + + Q ++ +
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 1171 E--VLQENYRLKNELEGLISE-KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQ 1227
E Q+N + +LE E +++L AV ++F++++ ++ A IA L+ +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE----AKIAQLEEQVE 1831
Query: 1228 REI-EKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE----LQSKQESLVVSEV 1282
+E EK +++ K+ E+ ++ + + ++ Q + ++ + L +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 1283 REEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK 1320
+ + KL EL EA E++ + L+ K++
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 117 bits (292), Expect = 1e-25
Identities = 177/856 (20%), Positives = 374/856 (43%), Gaps = 122/856 (14%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEEL------------ 654
+ K+ +LM K ++ + +R Q+ I + E+E + K+ ++
Sbjct: 742 DGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL 801
Query: 655 ------KKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQK 708
K+QQ+ K+ Q N KL +++ W P+ ++ + ++
Sbjct: 802 ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ-------WWRLFTKVKPLL--QVTRQEE 852
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKK--NEERMFKENQSLFSEVASLKEQMHKS 766
E+Q +E LQ ++ ++ N++K+L++++ + E+ + +E +E+ + E+M
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 767 RFLSQVVEDSEPTRNQNFTDLLAEL--RMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKK 824
+ Q ++L E+ R+ ++E +R K +Q L+++ + ++
Sbjct: 913 L----------AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 825 ERDQAKDQIAYVTGE----KLYEIKILEETHKQEISR----LQKRLQWYAENQELLDKDA 876
E + K Q+ VT E KL + ++ + ++S+ L++R+ N ++ A
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 877 LRLREANEEIEKLKLEIE-KLKAESGNPSIRQKIRLK---DKAADAKKIQDLERQVKEME 932
L + + E + E+E +LK E + +K++ K D + ++I DL+ Q+ E++
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 933 GILKRRYPNSLPALILAASAAGDTVDKNT----VEFMEKRIKKLEADLEGK---DEDAKK 985
L ++ AL A + KN + +E I L+ DL+ + A+K
Sbjct: 1083 MQLAKKEEELQAAL---ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 986 SLRTMEQQFQKMKIQYEQRLEQ--QEQLLACKLNQHDSPRIKALEKE-------LDDIKE 1036
R + ++ + +K + E L+ +Q L K Q + KAL++E + ++++
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 1037 AHQITVRNLEAEIDVLKHQNAELDVKKN--DKDDEDFQSIEFQV------EQAHAKAKLV 1088
H V L +++ K A LD K +K++ D E +V E H K KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG-ELRVLGQAKQEVEHKKKKLE 1258
Query: 1089 RLNEELAAK----KREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSK 1144
+EL +K +R +L+ V +LQ + + N E A + KDV S
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN---EAEGKAIKLAKDVASLSS 1315
Query: 1145 GNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSE---AVM 1201
++ +L Q T +VS L++ +N L+ + E+ E K E + +
Sbjct: 1316 QLQDT------QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 1202 NQFENSMRRVKEDTAAHIASL---KASHQREIEKLLCQNAVENSSSKVAELNRKIATQEV 1258
N + ++ +D A+ + +L K Q+EIE N + K A ++ T+
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-----NLTQQYEEKAAAYDKLEKTKNR 1424
Query: 1259 LIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPE--MKHFVGLE 1316
L + V +L ++++ +VS + ++ Q++ +LL E + + E E
Sbjct: 1425 LQQELDDLVVDLDNQRQ--LVSNLEKK--QRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 1317 KKIKQMEMRHAQREQ-ELQQIIQQTHQVVETEQ----------NKEVEKWKRLAQLKNRE 1365
K+ K + + A E E ++ +++T+++++ E K V + ++ + +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1366 LEKFRTELDSILDVLR 1381
+E+ +T+L+ + D L+
Sbjct: 1541 MEEMKTQLEELEDELQ 1556
Score = 100 bits (248), Expect = 1e-20
Identities = 200/988 (20%), Positives = 413/988 (41%), Gaps = 112/988 (11%)
Query: 460 SQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSG--LYASVRSSGYGK 517
+++D++ KT Q +E E + ++ + + LL+ + Q+ LYA
Sbjct: 856 AKEDELQKTKERQQKAENELKELEQK--HSQLTEEKNLLQEQLQAETELYAEAEE----- 908
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
+++ +K+ E+I+ R + R +++ + K + LD E
Sbjct: 909 ----MRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 578 CLSTRKKSENPTETDSCIQFQTDSLGYCGE-----NKEKKLL------MFKRVQEAEDKW 626
+ +K ++ I+ D + + +KE+KLL + + E E+K
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 627 RGAQALIEQIKATFSE------KEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFE 680
+ L + ++ SE KE++ +LE+LK++ E + ++ LQA+++ +
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 681 -ETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ-- 737
+ KK+ L +AA L ++ EI ++ L+ ++ L + DLQE
Sbjct: 1083 MQLAKKEEEL---QAA-------LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLD 1128
Query: 738 -NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQK 796
+ + K+ + L E+ +LK ++ + + ++ R Q T L L +
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 797 EKDSLLEDIKRLKQDKQALEV------DFEKMKKERDQAKDQIAYVTGEKLYEIKILEET 850
++ ++++++ + QA+E F++ K D+ K + + E+++L +
Sbjct: 1189 SHEAQVQEMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 851 HKQEISRLQKRLQWYAENQELLDK--DALRLR-EANEEIEKLKLEIEKLKAESGNPSIRQ 907
KQE+ +K+L+ A+ QEL K D R R E N+++ KL+ E+E + +
Sbjct: 1247 -KQEVEHKKKKLE--AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 908 KIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN--TVEFM 965
KD A+ + ++QD + ++E E K L L ++ D +D+ + +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 966 EKRIKKLE---ADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLAC--KLNQHD 1020
E+ I L +D + K +D ++ +E+ ++ + + E +Q E+ A KL +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1021 SPRIKALEKELDDIK---EAHQITVRNLEAE---IDVLKHQNAELDVKKNDKDDE----- 1069
+ L++ELDD+ + + V NLE + D L + + K D+ D
Sbjct: 1423 N----RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 1070 -----DFQSIEFQVEQA-HAKAKLVRLNEELAAKKREI----QDLSKTVERLQKDRRMM- 1118
S+ +E+A AK +L R N+ L A+ ++ D+ K V L+K +R +
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 1119 --LSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQEN 1176
+ ++ E +A +D + N + G + L D E ++
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQL 1594
Query: 1177 YRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ 1236
R +E E + ++ + + + A + E ++ ++ + I + + +++ KL Q
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI-KQLRKLQAQ 1653
Query: 1237 NAVENSSSKVAELNRK--IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKL 1294
+ A +R AT + + +S +L QE L +E + E +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 1295 LEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVV-ETEQNKEVE 1353
EEL + LE +I Q+E + + ++ + + + + EQ
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 1354 KWKRLAQLKN----RELEKFRTELDSIL 1377
+R KN ++LE+ EL S L
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKL 1801
Score = 95.5 bits (236), Expect = 3e-19
Identities = 147/697 (21%), Positives = 301/697 (43%), Gaps = 93/697 (13%)
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVED--SEPTRNQN 783
RL+ +VK L + ++ EE KE+ E+ KE+ K+ + +E S+ T +N
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKED-----ELQKTKERQQKAENELKELEQKHSQLTEEKN 890
Query: 784 FTDLLAELRMAQKEKDSLLEDIK-RLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLY 842
LL E A+ E + E+++ RL KQ LE +M+ ++ +D+ + E+
Sbjct: 891 ---LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER-- 945
Query: 843 EIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGN 902
+ Q++ L+++L+ +E + L+L + E + KLE E L + N
Sbjct: 946 ------KKMAQQMLDLEEQLE-----EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 903 PSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKN 960
+ ++ +L ++ +I DL + E E K + N ++I +K+
Sbjct: 995 NKLSKERKLLEE-----RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 961 TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD 1020
E ++KL+ LEG D + + ++ Q ++K+Q ++ E+ + LA +L+
Sbjct: 1050 RQE-----LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA-RLDDEI 1103
Query: 1021 SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ 1080
+ + AL+K + E H + +L+ ++D + + + +K D +E ++++ ++E
Sbjct: 1104 AQKNNALKKIRE--LEGH---ISDLQEDLDSERAARNKAEKQKRDLGEE-LEALKTELED 1157
Query: 1081 AHAKAKLVRLNEELAAKK-REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV 1139
+EL AK+ +E+ L K ++ + + K + + + +
Sbjct: 1158 T---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 1140 LHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEA 1199
+K N + TL+ +EN L EL L K E++ K +
Sbjct: 1215 FKRAKANLDKNKQTLE------------------KENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1200 VMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVL 1259
+ Q + + + A +A ++ KL QN VE+ + + E K L
Sbjct: 1257 LEAQVQELQSKCSDGERA-----RAELNDKVHKL--QNEVESVTGMLNEAEGKAIK---L 1306
Query: 1260 IRHFQSQVNELQSKQESLVVSEVREEI-LQKEITKLLEELREAKENHTPEMKHFVGLEKK 1318
+ S ++LQ QE L+ E R+++ + ++ +L EE ++ EM+ LE+
Sbjct: 1307 AKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 1319 IKQMEMRHAQREQELQQIIQQTHQVVETEQ--NKEVEK-----------WKRLAQLKNR- 1364
I + ++ + +++LQ + E ++ KE+E + +L + KNR
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 1365 --ELEKFRTELDSILDVLRELHRQGVVVPVAFADEMN 1399
EL+ +LD+ ++ L ++ A+E N
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 114 bits (286), Expect = 5e-25
Identities = 187/870 (21%), Positives = 392/870 (45%), Gaps = 112/870 (12%)
Query: 553 KKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKK 612
K+++ KL + + +D K + +KK + S I+ + +LG + K K+
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE-QALGIQLQKKIKE 1116
Query: 613 LLMFKRVQEAEDKW---RGAQALIEQIKATFSEKEKELENKLEE----------LKKQQE 659
L R++E E++ R ++A E+ ++ S + +E+ +LEE + K++E
Sbjct: 1117 LQA--RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 660 KELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQG 719
E K+ +D L+ E T R H A+ GE++ +Q+ Q+ E
Sbjct: 1175 AEFQKMRRD---LEEATLQHEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLEKEKSE 1229
Query: 720 YQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT 779
+ E + L + V+ + + K N E+M + + SE+ S +E+ + ++ D
Sbjct: 1230 MKMEIDDLASNVETVSKA-KGNLEKMCRTLEDQLSELKSKEEEQQR------LINDLTAQ 1282
Query: 780 RNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQ---AKDQIAYV 836
R + T+ E EK++L + +L + KQA E++K++ ++ AK+ +A+
Sbjct: 1283 RGRLQTES-GEFSRQLDEKEAL---VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 837 TGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIE--KLKLEIE 894
++ +L E +++E + AE Q L K AN E+ + K E +
Sbjct: 1339 LQSSRHDCDLLREQYEEE-------QESKAELQRALSK-------ANTEVAQWRTKYETD 1384
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALIL------ 948
++ ++K+ + +AA+ + ++ + + +E K+R N + L+L
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAE-EHVEAVNAKCASLEKT-KQRLQNEVEDLMLDVERTN 1442
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
AA AA D +N + + + +K E + + E ++K R++ + K+K YE+ L+Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 1009 EQLLACKLNQHDSPRIKALEKEL-DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKD 1067
E L + N++ I L +++ + K H++ + E + + Q A L+ + +
Sbjct: 1502 ETLK--RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ-AALEEAEASLE 1558
Query: 1068 DEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGR 1127
E+ + + Q+E K+++ R ++A K EI L + R+ + M S +++ R
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHIRIVES---MQSTLDAEIR 1612
Query: 1128 EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLI 1187
A R KK + +G+ N L+ H + + E R +G++
Sbjct: 1613 SRNDAIRLKKKM----EGDLNEMEIQLN------------HANRMAAEALRNYRNTQGIL 1656
Query: 1188 SEKN---ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKAS-HQREIEKLLCQNAVENSS 1243
+ + ++S+ + + + R A I L+A+ Q E + + + + ++S
Sbjct: 1657 KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 1244 SKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVR--EEILQKEITK---LLEEL 1298
+V L+ + + + ++ ++++Q + E ++ E R EE +K IT + EEL
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMED-ILQEARNAEEKAKKAITDAAMMAEEL 1775
Query: 1299 REAKEN--HTPEMKHFVGLEKKIKQMEMRHAQREQ-----------ELQQIIQQTHQVVE 1345
++ ++ H MK +E+ +K +++R + EQ +L+ +++ VE
Sbjct: 1776 KKEQDTSAHLERMKK--NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1833
Query: 1346 TEQNKEVEKWKRLAQLKNRELE-KFRTELD 1374
+EQ + E K L + + R E ++TE D
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKELTYQTEED 1863
Score = 98.6 bits (244), Expect = 4e-20
Identities = 175/819 (21%), Positives = 347/819 (42%), Gaps = 147/819 (17%)
Query: 650 KLEELKK--QQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQ 707
K++ L K + EKE+ + ++ ++ +L+ E K+ E + EK +Q
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE-----EKMVTLLKEK-NDLQ 894
Query: 708 KEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSR 767
++Q + L ++ ++L L+ + K+ ER ++ + + +E+ + K ++
Sbjct: 895 LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA-EDEEEINAELTAKKRKL---- 949
Query: 768 FLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD 827
ED ++ DL L +KEK + +K L ++ L+ K+ KE+
Sbjct: 950 ------EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK- 1002
Query: 828 QAKDQIAYVTGEKLYEIKILEETHKQEISRLQ---KRLQWYAENQELLDKDALRLREANE 884
K L+E H+Q + LQ ++ + + L++ L + E
Sbjct: 1003 -----------------KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 885 EIEKLKLEIEKLKAE-SGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRR--YPN 941
+ +KL++++E+ K + G+ + Q + I D+E + ++++ LK++ +
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQ-----------ESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 942 SLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLE------GKDEDAKKSL-------- 987
+L + I A G + K E ++ RI++LE ++E K E + L
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKE-LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 988 -----------------RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKE 1030
+ E +FQKM+ E+ Q E A +H + + L ++
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH-ADSVAELGEQ 1212
Query: 1031 LDDIKEAHQITVR---NLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK-AK 1086
+D+++ Q + ++ EID L N E K ++ +++E Q+ + +K +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLA-SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 1087 LVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGR---------------EEMS 1131
RL +L A++ +Q S R Q D + L +Q S+G+ EE+
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330
Query: 1132 AKRAKKDVLHSSKGNAN----SFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLI 1187
AK A L SS+ + + + +SK + ++ +EV Q +R K E + I
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN-TEVAQ--WRTKYETDA-I 1386
Query: 1188 SEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQR---EIEKLLCQNAVENSSS 1244
EL+ + + + + + V E A ASL+ + QR E+E L+ VE +++
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHV-EAVNAKCASLEKTKQRLQNEVEDLMLD--VERTNA 1443
Query: 1245 KVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVRE-------------------E 1285
A L++K + ++ ++ + E ++ E+ E R E
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 1286 ILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVE 1345
L++E L +E+ + E K LEK KQ+E Q + ELQ +++ +E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE----QEKCELQAALEEAEASLE 1558
Query: 1346 TEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELH 1384
E+ K + L Q+K+ E+++ E D +D L+ H
Sbjct: 1559 HEEGKILRIQLELNQVKS-EVDRKIAEKDEEIDQLKRNH 1596
Score = 90.9 bits (224), Expect = 8e-18
Identities = 161/850 (18%), Positives = 364/850 (42%), Gaps = 105/850 (12%)
Query: 590 ETDSCIQFQTDSLGY------CGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEK 643
+ D +Q Q ++ G C + + K+ + +++E ++ E+I A + K
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE----EEINAELTAK 945
Query: 644 EKELENKLEELKK---QQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTG 700
+++LE++ ELKK E L K+ ++ + + K+ N + E +T
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK-----NLTEEMAGLDETIAKLTK 1000
Query: 701 EKL------KQIQKEIQEQETLLQGYQQENERLYNQVKDLQ---EQNKKNEERMFKENQS 751
EK +Q ++Q +E + + +L QV DL+ EQ KK + + +
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 752 LFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQD 811
L ++ +E + Q +++ + ++L +++ Q L + IK L+
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 812 KQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQEL 871
+ LE + E + R +A+ Q + ++ +E+ + +RL+ A
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLS---------------RELEEISERLE-EAGGATS 1164
Query: 872 LDKDALRLREANEEIEKLKLEIEK--LKAESGNPSIRQKIRLKDKAADAKKIQDLERQVK 929
+ + REA E +K++ ++E+ L+ E+ ++R+K A ++I +L+R +
Sbjct: 1165 AQIEMNKKREA--EFQKMRRDLEEATLQHEATAATLRKK-HADSVAELGEQIDNLQRVKQ 1221
Query: 930 EMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRT 989
++E K + + LA++ + K +E M + ++ ++L+ K+E+ ++ +
Sbjct: 1222 KLE---KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 990 MEQQFQKMKI---QYEQRLEQQEQLLA--CKLNQHDSPRIKALEKELDDIKEAHQITVRN 1044
+ Q +++ ++ ++L+++E L++ + Q + +I+ L+++L++ +A
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 1045 LEA---EIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK--AKLVRLNEEL-AAKK 1098
L++ + D+L+ Q E K + +V Q K ++ EEL AKK
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAEL-QRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 1099 REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV---------LHSSKGNANS 1149
+ Q L E ++ S + +K R + + DV L + N +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1150 FPGTLDSKLYQPHTFTDSHVSEVLQ---ENYRLKNELEGLISEKNELKMKSEAVMNQFEN 1206
K + H ++ E E +++KN E + + LK +++ + + +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1207 SMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQ 1266
++ E K Q E EK Q A+E E + +E I Q +
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE-------EAEASLEHEEGKILRIQLE 1570
Query: 1267 VNELQSKQESLVVSEVREEI--LQKEITKLLEELREAKENHTPEMKHFVGLEKKIK---- 1320
+N+++S+ + ++E EEI L++ +++E ++ + + L+KK++
Sbjct: 1571 LNQVKSEVDR-KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 1321 --QMEMRHAQR--------EQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNR------ 1364
++++ HA R + Q I++ T ++ + + ++LA ++ R
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 1365 ELEKFRTELD 1374
E+E+ R L+
Sbjct: 1690 EIEELRATLE 1699
Score = 77.4 bits (189), Expect = 9e-14
Identities = 204/1088 (18%), Positives = 445/1088 (40%), Gaps = 162/1088 (14%)
Query: 123 DTLEEQEEKEQFFARLE-KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
+ E E++E+ A L K + S L K++D + T A++ ++H
Sbjct: 927 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL----------AKVEKEKHA 976
Query: 182 NESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML--AN 239
E+K + L E + DE + A LT +E + + + + + + EE+K L A
Sbjct: 977 TENKVKNLTEEMAG--LDETI-AKLT---KEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1030
Query: 240 VVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHI 299
+ L +D + E +L+++ K+ R E + ++ G +S D+E Q
Sbjct: 1031 IKLEQQVDDL-EGSLEQEKKL----RMDLERAKRKLEGDLKLAQESIMDIENEKQQL--- 1082
Query: 300 AHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSF 359
++K K + + +++S ++ + K I +++ +EEL + I +
Sbjct: 1083 ------DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA---RIEELEEEIEAERA 1133
Query: 360 GISGFDLQPVSS----EKVAER-KETEFFSSLPLKMNPNI------LSQDSQHVNLFFDK 408
+ + Q E+++ER +E +S ++MN + +D + L +
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 409 NDENVILQKTTNESMENSCPQVTEVTATEEHVDK------MYLNILRKKITVNSSSLSQD 462
L+K +S+ Q+ + ++ ++K M ++ L + S +
Sbjct: 1194 TAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 463 DKINKTYRSQLSS----EEEGAVMGKQVPYKKAR---SAPPLLKRKPQSGLYASVRSSGY 515
+K+ +T QLS EEE + + ++ R + ++ + S S G
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 516 GKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKT 575
+ ++ K+ E+ IK+KN +++ + Q + + L++ ++ K
Sbjct: 1312 QAFTQQIEEL----KRQLEEEIKAKN--ALAHALQSSRHDC----DLLREQYEEEQESKA 1361
Query: 576 ESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQ 635
E L N +++TD++ E +E K + +R+Q AE+ A
Sbjct: 1362 E--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS 1419
Query: 636 IKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAA 695
++ T ++ L+N++E+L E+ N L K +F++
Sbjct: 1420 LEKT----KQRLQNEVEDLMLDVERT----NAACAALDKKQRNFDKI------------- 1458
Query: 696 DPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ---VKDLQEQNKKNEERMFKENQSL 752
L + +++ +E L+ Q+E L + +K+ E++ E + +EN++L
Sbjct: 1459 -------LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 753 FSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDK 812
E++ L EQ+ + +E + Q +L A L A+ + I R++ +
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 813 QALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETH---------KQEISRLQKRLQ 863
++ + ++ E+D+ DQ+ K I+I+E + + RL+K+++
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQL------KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 864 WYAENQEL-------LDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAA 916
E+ + +ALR + I K +I A +++++ + ++ A
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 917 DAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEA 974
+ L+ +++E+ L++ R +L AS + + + KKLE
Sbjct: 1685 NL-----LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK-KKLET 1738
Query: 975 D---LEGKDEDAKKSLRTMEQQFQK-----MKIQYEQRLEQQEQLLACKLNQHDSPRIKA 1026
D ++G+ ED + R E++ +K + E + EQ ++ ++ +K
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD 1798
Query: 1027 LEKELDDIKEAH-----------QITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIE 1075
L+ LD+ ++ + VR LE E++ + +NAE VK K + + +
Sbjct: 1799 LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA-VKGLRKHERRVKELT 1857
Query: 1076 FQVEQAHAK-AKLVRLNEELAAKKREIQDLSKTVE-----RLQKDRRMMLSNQNSKGREE 1129
+Q E+ +L L ++L AK + + ++ E L K R++ + ++ R +
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Query: 1130 MSAKRAKK 1137
++ + K
Sbjct: 1918 IAESQVNK 1925
Score = 53.1 bits (126), Expect = 2e-06
Identities = 74/394 (18%), Positives = 165/394 (41%), Gaps = 57/394 (14%)
Query: 998 KIQYEQRLEQQEQLLACKLNQHDSP------------RIKALEKELDDIKEAHQITVRNL 1045
+++Y++ +E++E + + N +IK L K + KE + +
Sbjct: 804 RVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKE-----MATM 858
Query: 1046 EAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
+ E +K + A+ + K+ + +++ + E+ + ++ E LA + L
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEK---MVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSA-----KRAKKDVLHSSKGNANSFPGTLDSKLYQ 1160
KT ++Q + ++ + ++ EE++A KR +D K + + TL +
Sbjct: 916 KT--KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 973
Query: 1161 PHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIA 1220
H T++ V + +E L + L EK L+ + ++ + +ED +
Sbjct: 974 KHA-TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-----AEEDKVNTLT 1027
Query: 1221 SLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVS 1280
K +++++ L + ++E +L R E +L+ QES++
Sbjct: 1028 KAKIKLEQQVDDL--EGSLEQEKKLRMDLERAKRKLE----------GDLKLAQESIMDI 1075
Query: 1281 EVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQT 1340
E ++ L +++ K E+ + E + L+KKIK+++ R + E+E
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE-------- 1127
Query: 1341 HQVVETEQNKEVEKWKRLAQLKNRELEKFRTELD 1374
+E E+ + K+ + L +RELE+ L+
Sbjct: 1128 ---IEAERASRAKAEKQRSDL-SRELEEISERLE 1157
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 114 bits (286), Expect = 5e-25
Identities = 187/870 (21%), Positives = 392/870 (45%), Gaps = 112/870 (12%)
Query: 553 KKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKK 612
K+++ KL + + +D K + +KK + S I+ + +LG + K K+
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE-QALGIQLQKKIKE 1116
Query: 613 LLMFKRVQEAEDKW---RGAQALIEQIKATFSEKEKELENKLEE----------LKKQQE 659
L R++E E++ R ++A E+ ++ S + +E+ +LEE + K++E
Sbjct: 1117 LQA--RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 660 KELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQG 719
E K+ +D L+ E T R H A+ GE++ +Q+ Q+ E
Sbjct: 1175 AEFQKMRRD---LEEATLQHEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLEKEKSE 1229
Query: 720 YQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT 779
+ E + L + V+ + + K N E+M + + SE+ S +E+ + ++ D
Sbjct: 1230 MKMEIDDLASNVETVSKA-KGNLEKMCRTLEDQLSELKSKEEEQQR------LINDLTAQ 1282
Query: 780 RNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQ---AKDQIAYV 836
R + T+ E EK++L + +L + KQA E++K++ ++ AK+ +A+
Sbjct: 1283 RGRLQTES-GEFSRQLDEKEAL---VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 837 TGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIE--KLKLEIE 894
++ +L E +++E + AE Q L K AN E+ + K E +
Sbjct: 1339 LQSSRHDCDLLREQYEEE-------QESKAELQRALSK-------ANTEVAQWRTKYETD 1384
Query: 895 KLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALIL------ 948
++ ++K+ + +AA+ + ++ + + +E K+R N + L+L
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAE-EHVEAVNAKCASLEKT-KQRLQNEVEDLMLDVERTN 1442
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ 1008
AA AA D +N + + + +K E + + E ++K R++ + K+K YE+ L+Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 1009 EQLLACKLNQHDSPRIKALEKEL-DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKD 1067
E L + N++ I L +++ + K H++ + E + + Q A L+ + +
Sbjct: 1502 ETLK--RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ-AALEEAEASLE 1558
Query: 1068 DEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGR 1127
E+ + + Q+E K+++ R ++A K EI L + R+ + M S +++ R
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHIRIVES---MQSTLDAEIR 1612
Query: 1128 EEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLI 1187
A R KK + +G+ N L+ H + + E R +G++
Sbjct: 1613 SRNDAIRLKKKM----EGDLNEMEIQLN------------HANRMAAEALRNYRNTQGIL 1656
Query: 1188 SEKN---ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKAS-HQREIEKLLCQNAVENSS 1243
+ + ++S+ + + + R A I L+A+ Q E + + + + ++S
Sbjct: 1657 KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 1244 SKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVR--EEILQKEITK---LLEEL 1298
+V L+ + + + ++ ++++Q + E ++ E R EE +K IT + EEL
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMED-ILQEARNAEEKAKKAITDAAMMAEEL 1775
Query: 1299 REAKEN--HTPEMKHFVGLEKKIKQMEMRHAQREQ-----------ELQQIIQQTHQVVE 1345
++ ++ H MK +E+ +K +++R + EQ +L+ +++ VE
Sbjct: 1776 KKEQDTSAHLERMKK--NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1833
Query: 1346 TEQNKEVEKWKRLAQLKNRELE-KFRTELD 1374
+EQ + E K L + + R E ++TE D
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKELTYQTEED 1863
Score = 98.6 bits (244), Expect = 4e-20
Identities = 175/819 (21%), Positives = 347/819 (42%), Gaps = 147/819 (17%)
Query: 650 KLEELKK--QQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQ 707
K++ L K + EKE+ + ++ ++ +L+ E K+ E + EK +Q
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE-----EKMVTLLKEK-NDLQ 894
Query: 708 KEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSR 767
++Q + L ++ ++L L+ + K+ ER ++ + + +E+ + K ++
Sbjct: 895 LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA-EDEEEINAELTAKKRKL---- 949
Query: 768 FLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERD 827
ED ++ DL L +KEK + +K L ++ L+ K+ KE+
Sbjct: 950 ------EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK- 1002
Query: 828 QAKDQIAYVTGEKLYEIKILEETHKQEISRLQ---KRLQWYAENQELLDKDALRLREANE 884
K L+E H+Q + LQ ++ + + L++ L + E
Sbjct: 1003 -----------------KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 885 EIEKLKLEIEKLKAE-SGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRR--YPN 941
+ +KL++++E+ K + G+ + Q + I D+E + ++++ LK++ +
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQ-----------ESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 942 SLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLE------GKDEDAKKSL-------- 987
+L + I A G + K E ++ RI++LE ++E K E + L
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKE-LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 988 -----------------RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKE 1030
+ E +FQKM+ E+ Q E A +H + + L ++
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH-ADSVAELGEQ 1212
Query: 1031 LDDIKEAHQITVR---NLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK-AK 1086
+D+++ Q + ++ EID L N E K ++ +++E Q+ + +K +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLA-SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 1087 LVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGR---------------EEMS 1131
RL +L A++ +Q S R Q D + L +Q S+G+ EE+
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330
Query: 1132 AKRAKKDVLHSSKGNAN----SFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLI 1187
AK A L SS+ + + + +SK + ++ +EV Q +R K E + I
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN-TEVAQ--WRTKYETDA-I 1386
Query: 1188 SEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQR---EIEKLLCQNAVENSSS 1244
EL+ + + + + + V E A ASL+ + QR E+E L+ VE +++
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHV-EAVNAKCASLEKTKQRLQNEVEDLMLD--VERTNA 1443
Query: 1245 KVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVRE-------------------E 1285
A L++K + ++ ++ + E ++ E+ E R E
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 1286 ILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVE 1345
L++E L +E+ + E K LEK KQ+E Q + ELQ +++ +E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE----QEKCELQAALEEAEASLE 1558
Query: 1346 TEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELH 1384
E+ K + L Q+K+ E+++ E D +D L+ H
Sbjct: 1559 HEEGKILRIQLELNQVKS-EVDRKIAEKDEEIDQLKRNH 1596
Score = 90.9 bits (224), Expect = 8e-18
Identities = 161/850 (18%), Positives = 364/850 (42%), Gaps = 105/850 (12%)
Query: 590 ETDSCIQFQTDSLGY------CGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEK 643
+ D +Q Q ++ G C + + K+ + +++E ++ E+I A + K
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE----EEINAELTAK 945
Query: 644 EKELENKLEELKK---QQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTG 700
+++LE++ ELKK E L K+ ++ + + K+ N + E +T
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK-----NLTEEMAGLDETIAKLTK 1000
Query: 701 EKL------KQIQKEIQEQETLLQGYQQENERLYNQVKDLQ---EQNKKNEERMFKENQS 751
EK +Q ++Q +E + + +L QV DL+ EQ KK + + +
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 752 LFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQD 811
L ++ +E + Q +++ + ++L +++ Q L + IK L+
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 812 KQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQEL 871
+ LE + E + R +A+ Q + ++ +E+ + +RL+ A
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLS---------------RELEEISERLE-EAGGATS 1164
Query: 872 LDKDALRLREANEEIEKLKLEIEK--LKAESGNPSIRQKIRLKDKAADAKKIQDLERQVK 929
+ + REA E +K++ ++E+ L+ E+ ++R+K A ++I +L+R +
Sbjct: 1165 AQIEMNKKREA--EFQKMRRDLEEATLQHEATAATLRKK-HADSVAELGEQIDNLQRVKQ 1221
Query: 930 EMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRT 989
++E K + + LA++ + K +E M + ++ ++L+ K+E+ ++ +
Sbjct: 1222 KLE---KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 990 MEQQFQKMKI---QYEQRLEQQEQLLA--CKLNQHDSPRIKALEKELDDIKEAHQITVRN 1044
+ Q +++ ++ ++L+++E L++ + Q + +I+ L+++L++ +A
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 1045 LEA---EIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK--AKLVRLNEEL-AAKK 1098
L++ + D+L+ Q E K + +V Q K ++ EEL AKK
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAEL-QRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 1099 REIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDV---------LHSSKGNANS 1149
+ Q L E ++ S + +K R + + DV L + N +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1150 FPGTLDSKLYQPHTFTDSHVSEVLQ---ENYRLKNELEGLISEKNELKMKSEAVMNQFEN 1206
K + H ++ E E +++KN E + + LK +++ + + +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1207 SMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQ 1266
++ E K Q E EK Q A+E E + +E I Q +
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE-------EAEASLEHEEGKILRIQLE 1570
Query: 1267 VNELQSKQESLVVSEVREEI--LQKEITKLLEELREAKENHTPEMKHFVGLEKKIK---- 1320
+N+++S+ + ++E EEI L++ +++E ++ + + L+KK++
Sbjct: 1571 LNQVKSEVDR-KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 1321 --QMEMRHAQR--------EQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNR------ 1364
++++ HA R + Q I++ T ++ + + ++LA ++ R
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 1365 ELEKFRTELD 1374
E+E+ R L+
Sbjct: 1690 EIEELRATLE 1699
Score = 77.4 bits (189), Expect = 9e-14
Identities = 204/1088 (18%), Positives = 445/1088 (40%), Gaps = 162/1088 (14%)
Query: 123 DTLEEQEEKEQFFARLE-KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
+ E E++E+ A L K + S L K++D + T A++ ++H
Sbjct: 927 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL----------AKVEKEKHA 976
Query: 182 NESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML--AN 239
E+K + L E + DE + A LT +E + + + + + + EE+K L A
Sbjct: 977 TENKVKNLTEEMAG--LDETI-AKLT---KEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1030
Query: 240 VVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHI 299
+ L +D + E +L+++ K+ R E + ++ G +S D+E Q
Sbjct: 1031 IKLEQQVDDL-EGSLEQEKKL----RMDLERAKRKLEGDLKLAQESIMDIENEKQQL--- 1082
Query: 300 AHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSF 359
++K K + + +++S ++ + K I +++ +EEL + I +
Sbjct: 1083 ------DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA---RIEELEEEIEAERA 1133
Query: 360 GISGFDLQPVSS----EKVAER-KETEFFSSLPLKMNPNI------LSQDSQHVNLFFDK 408
+ + Q E+++ER +E +S ++MN + +D + L +
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 409 NDENVILQKTTNESMENSCPQVTEVTATEEHVDK------MYLNILRKKITVNSSSLSQD 462
L+K +S+ Q+ + ++ ++K M ++ L + S +
Sbjct: 1194 TAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 463 DKINKTYRSQLSS----EEEGAVMGKQVPYKKAR---SAPPLLKRKPQSGLYASVRSSGY 515
+K+ +T QLS EEE + + ++ R + ++ + S S G
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 516 GKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKT 575
+ ++ K+ E+ IK+KN +++ + Q + + L++ ++ K
Sbjct: 1312 QAFTQQIEEL----KRQLEEEIKAKN--ALAHALQSSRHDC----DLLREQYEEEQESKA 1361
Query: 576 ESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQ 635
E L N +++TD++ E +E K + +R+Q AE+ A
Sbjct: 1362 E--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS 1419
Query: 636 IKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAA 695
++ T ++ L+N++E+L E+ N L K +F++
Sbjct: 1420 LEKT----KQRLQNEVEDLMLDVERT----NAACAALDKKQRNFDKI------------- 1458
Query: 696 DPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ---VKDLQEQNKKNEERMFKENQSL 752
L + +++ +E L+ Q+E L + +K+ E++ E + +EN++L
Sbjct: 1459 -------LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 753 FSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDK 812
E++ L EQ+ + +E + Q +L A L A+ + I R++ +
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 813 QALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETH---------KQEISRLQKRLQ 863
++ + ++ E+D+ DQ+ K I+I+E + + RL+K+++
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQL------KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 864 WYAENQEL-------LDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAA 916
E+ + +ALR + I K +I A +++++ + ++ A
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 917 DAKKIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEA 974
+ L+ +++E+ L++ R +L AS + + + KKLE
Sbjct: 1685 NL-----LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK-KKLET 1738
Query: 975 D---LEGKDEDAKKSLRTMEQQFQK-----MKIQYEQRLEQQEQLLACKLNQHDSPRIKA 1026
D ++G+ ED + R E++ +K + E + EQ ++ ++ +K
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD 1798
Query: 1027 LEKELDDIKEAH-----------QITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIE 1075
L+ LD+ ++ + VR LE E++ + +NAE VK K + + +
Sbjct: 1799 LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA-VKGLRKHERRVKELT 1857
Query: 1076 FQVEQAHAK-AKLVRLNEELAAKKREIQDLSKTVE-----RLQKDRRMMLSNQNSKGREE 1129
+Q E+ +L L ++L AK + + ++ E L K R++ + ++ R +
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Query: 1130 MSAKRAKK 1137
++ + K
Sbjct: 1918 IAESQVNK 1925
Score = 53.1 bits (126), Expect = 2e-06
Identities = 74/394 (18%), Positives = 165/394 (41%), Gaps = 57/394 (14%)
Query: 998 KIQYEQRLEQQEQLLACKLNQHDSP------------RIKALEKELDDIKEAHQITVRNL 1045
+++Y++ +E++E + + N +IK L K + KE + +
Sbjct: 804 RVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKE-----MATM 858
Query: 1046 EAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLS 1105
+ E +K + A+ + K+ + +++ + E+ + ++ E LA + L
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEK---MVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 1106 KTVERLQKDRRMMLSNQNSKGREEMSA-----KRAKKDVLHSSKGNANSFPGTLDSKLYQ 1160
KT ++Q + ++ + ++ EE++A KR +D K + + TL +
Sbjct: 916 KT--KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 973
Query: 1161 PHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIA 1220
H T++ V + +E L + L EK L+ + ++ + +ED +
Sbjct: 974 KHA-TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-----AEEDKVNTLT 1027
Query: 1221 SLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVS 1280
K +++++ L + ++E +L R E +L+ QES++
Sbjct: 1028 KAKIKLEQQVDDL--EGSLEQEKKLRMDLERAKRKLE----------GDLKLAQESIMDI 1075
Query: 1281 EVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQT 1340
E ++ L +++ K E+ + E + L+KKIK+++ R + E+E
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE-------- 1127
Query: 1341 HQVVETEQNKEVEKWKRLAQLKNRELEKFRTELD 1374
+E E+ + K+ + L +RELE+ L+
Sbjct: 1128 ---IEAERASRAKAEKQRSDL-SRELEEISERLE 1157
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 113 bits (283), Expect = 1e-24
Identities = 192/877 (21%), Positives = 381/877 (43%), Gaps = 126/877 (14%)
Query: 591 TDSCIQFQTDSLGYCGEN----KEKKLLMFKRVQE---AEDKWRGAQ--ALIEQIKATF- 640
TD I FQ GY ++++L K +Q A K R Q L ++K
Sbjct: 780 TDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQ 839
Query: 641 -SEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVT 699
S +E+E+ K EEL K +EK+L N +L+ E + +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAEN--------RLTEMETLQSQ------------LM 879
Query: 700 GEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASL 759
EKL Q+Q+++Q + L ++ RL + ++L+E E R+ +E + A
Sbjct: 880 AEKL-QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 760 KEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDF 819
K+ + L + +E+ E R + Q EK + +K+L++++ LE
Sbjct: 939 KKMQQNIQELEEQLEEEESARQK-----------LQLEKVTTEAKLKKLEEEQIILEDQN 987
Query: 820 EKMKKERDQAKDQIAYVT------GEKLYEIKILEETHKQEISRLQKRLQWYAENQELLD 873
K+ KE+ +D+IA T EK + L+ H+ I+ L++RL+ + ++ L+
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE 1047
Query: 874 KDALRLR-----------EANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQ 922
K +L E +I +LK+++ K + E R + K KKI+
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR 1107
Query: 923 DLERQVKEMEGIL-------------KRRYPNSLPALILAASAAGDTVDKNTV--EFMEK 967
+LE Q+ E++ L KR L AL + DT+D E K
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELEAL---KTELEDTLDSTAAQQELRSK 1164
Query: 968 RIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKAL 1027
R +++ + +E+AK +++ QK E+ EQ EQ K N + + L
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK--QTL 1222
Query: 1028 EKELDDIKEAHQITVR---NLEAEIDVLKHQNAELDVKKND----KDDEDFQSIEFQVE- 1079
E E ++ ++ ++ + E + ++ Q EL VK N+ + + + + QVE
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 1080 ------QAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRR--MMLSNQNSKGREEMS 1131
+ + +K +L ++ +A + ++QD T E LQ++ R + LS + + +E +
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQD---TQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 1132 AKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVS--EVLQE-NYRLKNELEGLIS 1188
+ R + + +K N TL +++ + V E +E +L+ +LEGL S
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL-S 1398
Query: 1189 EKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKAS------HQREIEKLLCQNAVENS 1242
+++E K+ + + + + +++ +D + + S Q++ ++LL + +
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE--KTI 1456
Query: 1243 SSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAK 1302
S+K AE + E R +++ L E + + E L K+ +E+L +K
Sbjct: 1457 SAKYAEERDR---AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 1303 EN-----HTPEMKHFVGLEKKIKQMEMRHAQREQELQQI------IQQTHQVVETEQNKE 1351
++ H E K LE+++++M+ + + E ELQ ++ Q ++ + ++
Sbjct: 1514 DDVGKSVHELE-KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 1352 VEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQGV 1388
++ ++ K ++L + E+++ L+ R+ V
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Score = 113 bits (282), Expect = 1e-24
Identities = 178/892 (19%), Positives = 383/892 (42%), Gaps = 102/892 (11%)
Query: 528 LEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSEN 587
LEK T+E +K I +Q K + KL++ + + TE ++ ++
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCK--LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 588 PTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAE-----DKWRGAQALIEQIKATFSE 642
+ ++ I + L E + ++L +R E + D+ QA I ++K ++
Sbjct: 1022 KNKHEAMITDLEERLRR-EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 643 KEKELENKL---EELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWL-HFGEAADPV 698
KE+EL+ L EE Q+ L K+ + L++++S +E + +R + E
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRD 1136
Query: 699 TGEKLKQIQKEIQEQETLLQGYQQENERLYNQV----KDLQEQNKKNEERMFKENQSLFS 754
GE+L+ ++ E+++ Q+ + +V K L+E+ K +E ++ + Q
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 755 EVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQA 814
V L EQ+ +++ + +E ++ T +L E+++ + K K+++ Q
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256
Query: 815 LEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHK------QEISRLQKRLQWYAEN 868
L+V F + ++ R + D++ + E +L ++ ++ S L+ +LQ +
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ---DT 1313
Query: 869 QELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAAD--AKKIQDLER 926
QELL + E +KL L + + E S R+++ +++A K+I L
Sbjct: 1314 QELLQE---------ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 927 QVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKS 986
QV +M K++ +S+ L E E+ +KL+ DLEG + ++
Sbjct: 1365 QVADM----KKKMEDSVGCL----------------ETAEEVKRKLQKDLEGLSQRHEEK 1404
Query: 987 LRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLE 1046
+ + + +K K + +Q L+ + L+ + + ++ +K+ D + A + T+
Sbjct: 1405 VAAYD-KLEKTKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLL-AEEKTISAKY 1460
Query: 1047 AEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREI----Q 1102
AE + AE + + +K+ + E KA+L RLN++ + ++
Sbjct: 1461 AE----ERDRAEAEAR--EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD 1514
Query: 1103 DLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPH 1162
D+ K+V L+K +R L Q + + ++ + +K + ++ +
Sbjct: 1515 DVGKSVHELEKSKR-ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573
Query: 1163 TFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASL 1222
D E ++ R E+E + ++ + + + A + E ++ D AHI S
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK----DLEAHIDSA 1629
Query: 1223 KASHQREIEKLL--------CQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQ 1274
+ I++L C ++++ + E+ + E ++ ++++ +L Q
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL---Q 1686
Query: 1275 ESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQ 1334
E L +E + Q+E +L +E+ + K + LE+K +++E R AQ E+EL+
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSG------KGALALEEK-RRLEARIAQLEEELE 1739
Query: 1335 QIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQ 1386
+ T + N ++K N +L R+ + ++L RQ
Sbjct: 1740 EEQGNTELI-----NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786
Score = 98.6 bits (244), Expect = 4e-20
Identities = 189/863 (21%), Positives = 368/863 (42%), Gaps = 139/863 (16%)
Query: 609 KEKKLLMFKRVQEAEDKWRGAQA----LIEQIKATFSEKEKELENKLEELKKQQEKELFK 664
+EK+L R+ E E A L EQ++A E EL + EEL+ + + +
Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA-----ETELCAEAEELRARLTAKKQE 912
Query: 665 LNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQEN 724
L + + L+A++ EE R H +A + +++++++++E+E+ Q Q E
Sbjct: 913 LEEICHDLEARVEEEEE-----RCQHL-QAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 725 ERLYNQVKDLQEQNKKNEE---RMFKENQSLFSEVA----SLKEQMHKSRFLSQVVEDSE 777
++K L+E+ E+ ++ KE + L +A +L E+ KS+ L+++ E
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026
Query: 778 PTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVT 837
TDL LR +K++ L + ++L+ D L +++ + + K Q+A
Sbjct: 1027 AM----ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082
Query: 838 GEKLYEIKILEETHKQEISRLQKRLQWYAENQELLD----------KDALRLREANEEIE 887
E + +EE Q+ L+K + ++ EL + K + R+ EE+E
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 888 KLKLEIE-KLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPAL 946
LK E+E L + + +R K +++ + K + LE + K E ++ A+
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSK---REQEVNILK-KTLEEEAKTHEAQIQEMRQKHSQAV 1198
Query: 947 ILAASAAGDTVDKNTVEFMEKRIKKLEAD-----------LEGKDEDAKKSLRTMEQQFQ 995
A T K +EK + LE + L+GK D++ + +E Q Q
Sbjct: 1199 EELAEQLEQT--KRVKANLEKAKQTLENERGELANEVKVLLQGKG-DSEHKRKKVEAQLQ 1255
Query: 996 KMKIQYEQ-------------RLEQQEQLLACKLNQHDSPRIK------ALEKELDDIKE 1036
++++++ + +L+ + + L+Q DS K ALE +L D +E
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 1037 AHQITVRNLEAEIDVLKHQNAELDV--KKNDKDDEDFQSIEFQVEQAHA----------- 1083
Q R + LK E + ++ ++++E ++E Q+ HA
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 1084 -----------KAKLVRLNEELAAKKRE----IQDLSKTVERLQKDRRMMLSNQNSKGRE 1128
K KL + E L+ + E L KT RLQ++ +L + + + +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 1129 --EMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGL 1186
+ K+ K D L + + T+ +K + ++ E + L LE
Sbjct: 1436 ACNLEKKQKKFDQLLAEE-------KTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488
Query: 1187 ISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKV 1246
+ +K EL+ ++ + E+ M K+D K+ H+ E K + VE +++
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSS-KDDVG------KSVHELEKSKRALEQQVEEMKTQL 1541
Query: 1247 AELNRKI-ATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENH 1305
EL ++ AT++ +R +VN K + + R+E +++ +L+ ++RE +
Sbjct: 1542 EELEDELQATEDAKLR---LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE- 1597
Query: 1306 TPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRL----AQL 1361
LE + KQ M A R ++L+ ++ +++ E K+L AQ+
Sbjct: 1598 ---------LEDERKQRSMAVAAR-KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 1362 KN--RELEKFRTELDSILDVLRE 1382
K+ REL+ R + IL +E
Sbjct: 1648 KDCMRELDDTRASREEILAQAKE 1670
Score = 95.5 bits (236), Expect = 3e-19
Identities = 199/1067 (18%), Positives = 434/1067 (40%), Gaps = 167/1067 (15%)
Query: 14 EQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWW---ITEDDFKDDGLLGTNVSYLKTK 70
E +K+L ++ D+ + +K++ +D + + +TE++ K L +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 71 KTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEE 130
+ + EE+ ++++ + L DS + ++ + +EL + + +++EE
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRK----LEGDSTDLSDQI-AELQAQIAELKMQLAKKEEE 1084
Query: 131 KEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEELA 190
+ AR+E+ + +EL+S S + L S +A+ + + + + E
Sbjct: 1085 LQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144
Query: 191 ENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVA 250
+ +D D T +E+ SK + + +EE KT A + + S A
Sbjct: 1145 KTELEDTLDS------TAAQQELRSKREQEVNILKKTLEEEAKTHE-AQIQEMRQKHSQA 1197
Query: 251 EVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQK 310
L EQ + T + + E + + G+ +++V+ L Q H ++K
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLEN---ERGELANEVKVLLQGKGDSEHK-----RKK 1249
Query: 311 IESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVS 370
+E+ +++++ + E + ++ ++ +L V L+ S
Sbjct: 1250 VEAQ-LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLL------------------S 1290
Query: 371 SEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQ---KTTNESMENSC 427
K T+ FS+L ++ QD+Q L ++N + + L K + +
Sbjct: 1291 QSDSKSSKLTKDFSALESQL------QDTQE--LLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 428 PQVTEVTATEEHVDKMYLNI------LRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAV 481
Q+ E + +++K + ++KK+ + L +++ + + L +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 482 MGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS--EDIIKS 539
K Y K K + Q L + + + S+ LEKK + ++
Sbjct: 1403 E-KVAAYDKLEKT----KTRLQQELDDLLVDLDHQRQSA-----CNLEKKQKKFDQLLAE 1452
Query: 540 KNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQT 599
+ S + + + E + K K +L A E + + + E + QF+T
Sbjct: 1453 EKTISAKYAEERDRAEAEAREKETKALSL---ARALEEAMEQKAELERLNK-----QFRT 1504
Query: 600 DSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQE 659
+ + + K V E E R + +E++K E E EL+ E+ K + E
Sbjct: 1505 EMEDLMSSKDD----VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ-ATEDAKLRLE 1559
Query: 660 KELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQG 719
L QA + FE + D + EK KQ+ ++++E E L+
Sbjct: 1560 VNL----------QAMKAQFERDL---------QGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 720 YQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT 779
+++ K L+ K E + N++ + L++ + + + ++D+ +
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 780 RNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGE 839
R + +LA+ + +K+ S+ ++ +L+++ A E + ++ERD+ D+IA +G+
Sbjct: 1661 REE----ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGK 1716
Query: 840 KLYEIKILEETHKQE--ISRLQKRLQWYAENQELLDKDALRLREANEEIEKLK--LEIEK 895
LEE + E I++L++ L+ N EL++ RL++AN +I+++ L +E+
Sbjct: 1717 GALA---LEEKRRLEARIAQLEEELEEEQGNTELIND---RLKKANLQIDQINTDLNLER 1770
Query: 896 LKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGD 955
A+ N + RQ++ ++K +L+ +++EMEG +K +Y S+ AL + +
Sbjct: 1771 SHAQK-NENARQQLERQNK--------ELKVKLQEMEGTVKSKYKASITALEAKIAQLEE 1821
Query: 956 TVDKNTVEFM-------------------------------------EKRIKKLEADLEG 978
+D T E R+K+L+ LE
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881
Query: 979 KDEDAKK---SLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSP 1022
+E+A++ S R ++++ + + + ++ L KL + D P
Sbjct: 1882 AEEEAQRANASRRKLQRELED-ATETADAMNREVSSLKNKLRRGDLP 1927
Score = 89.4 bits (220), Expect = 2e-17
Identities = 195/1051 (18%), Positives = 449/1051 (42%), Gaps = 163/1051 (15%)
Query: 206 LTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPR 265
++ ++EEM +KE E + V +++ L + L S ++ L EQ + +
Sbjct: 840 VSRQEEEMMAKEE---ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 266 CLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKG 325
E +T + D+EA + L E K+K++ N +++++ +
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAE-KKKMQQN-IQELEEQL-- 952
Query: 326 HPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSS 385
E EE+++ +E T E +K + + + + + +K+ E + EF ++
Sbjct: 953 ---EEEESARQKLQLEK--VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 386 LPLK--MNPNILSQDSQHVNLFFDKND-------ENVILQKTTNESMENSCPQVTEVTAT 436
L + + ++ ++H + D + + L+KT + +S ++
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 437 EEHVDKMYLNILRKKITVNSS-SLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAP 495
+ + ++ + + +K+ + ++ + +++ K + E E + Q + R++
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 496 PLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKE 555
+++ R G + ++ TL+ ++ ++SK + ++ + ++E
Sbjct: 1128 NKAEKQK--------RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 556 ILSGTKLIKPA------ALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENK 609
+ I+ A+++ A + E T++ N + ++ + L N+
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQ---TKRVKANLEKAKQTLENERGELA----NE 1232
Query: 610 EKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEK---ELENKLEELK----------K 656
K LL K ++E K + +A +++++ F+E E+ EL +K+ +L+
Sbjct: 1233 VKVLLQGKG--DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 657 QQEKELFKLNQDNYILQAKLSSFEET--NKKQRWLHFGEAADPVTGEKLKQIQKEIQEQE 714
Q + + KL +D L+++L +E + ++ L V EK +++++E+E
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK-NSFREQLEEEE 1349
Query: 715 TLLQGYQQENERLYNQVKDLQEQNKKNE---ERMFKENQSLFSEVASLKEQMHKSRFLSQ 771
+++ L+ QV D++++ + + E + + L ++ L ++ +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409
Query: 772 VVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKD 831
+E ++ Q DLL +L ++ +L + K+ Q + K +ERD+A+
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 832 QIAYVTGEKLYEIKILEETHKQ--EISRLQKRLQWYAENQELLD-KDAL---------RL 879
+ + L + LEE +Q E+ RL K Q+ E ++L+ KD +
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNK--QFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 880 REANEEIEKLKLEIEKLKAE---SGNPSIRQKIRL-------------KDKAADAKKIQD 923
R +++E++K ++E+L+ E + + +R ++ L +D+ ++ KK Q
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ- 1586
Query: 924 LERQVKEMEGILKRRYPNSLPAL---------ILAASAAGDTVDKNTVEFMEKRIKKLEA 974
L RQV+EME L+ A+ + A D+ +KN E + K+++KL+A
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI-KQLRKLQA 1645
Query: 975 DLE-----------------GKDEDAKKSLRTMEQQFQKMK-----IQYEQRLEQQEQ-- 1010
++ + ++ +K L++ME + +++ + +R QQE+
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705
Query: 1011 ------------LLACKLNQHDSPRIKALEKELDD-----------IKEAH-QITVRNLE 1046
LA + + RI LE+EL++ +K+A+ QI N +
Sbjct: 1706 LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD 1765
Query: 1047 AEID---VLKHQNAELDVKKNDKDDE-DFQSIEFQVEQAHA------KAKLVRLNEELAA 1096
++ K++NA +++ +K+ + Q +E V+ + +AK+ +L E+L
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825
Query: 1097 KKREIQDLSKTVERLQKDRRMMLSNQNSKGR 1127
+ +E Q K V R +K + +L + + R
Sbjct: 1826 ETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 112 bits (280), Expect = 2e-24
Identities = 274/1338 (20%), Positives = 558/1338 (41%), Gaps = 239/1338 (17%)
Query: 9 LDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNVSYLK 68
L + EQ MKE+ E++DK +QS + ++D I D + + L+
Sbjct: 454 LSVKLEQAMKEIQRLQ-EDTDKANKQSS--VLERDNRRMEIQVKDLSQQ--IRVLLMELE 508
Query: 69 TKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQ 128
+ + + + E SA+ SS + ++S + + + + L V L L E
Sbjct: 509 EARGNHVIRDEEVSSADI-----SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGET 563
Query: 129 EEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEE 188
E+E+ T+S + L +L+S + + S Q +L D +
Sbjct: 564 REREE-------QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
Query: 189 LAENYSDDFEDEYVGAPL---TTKDEEMPS--KENSKSEKISVPKQEEEKTGMLANVVLL 243
L + V PL + D + S K S S+ +S P A V ++
Sbjct: 617 LLSQTTG------VAIPLHASSLDDVSLASTPKRPSTSQTVSTP----------APVPVI 660
Query: 244 DSLDSV-AEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHI-AH 301
+S +++ A+ L + +I + E ENE + +E L + + +
Sbjct: 661 ESTEAIEAKAALKQLQEIFENYK--KEKAENEKI--------QNEQLEKLQEQVTDLRSQ 710
Query: 302 SLGDEDKQKIESNTVEDIKSSVKGHPQE----NEENSKNISTMESDLPTVEELMKPIRID 357
+ + S E ++ +V+G+ +E +E N K +T + + + + +R
Sbjct: 711 NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
Query: 358 SFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENV--IL 415
+ ++ + V +E + + KE S + L L + + NL N + + IL
Sbjct: 771 NEKLA---VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT-NLQTIQGIL 826
Query: 416 QKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSS 475
+++ E+ + Q+ ++ H+ K N + ++ T+ + D ++ T R QL +
Sbjct: 827 ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL---DVQLLDTKR-QLDT 882
Query: 476 EEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSS---GYGKPSSPLKMFSTLE--K 530
E + K++ + L + + + +SS G G+PS+ + + +
Sbjct: 883 ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 531 KTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTE 590
+T E + K STSN + + +++ + +L+K TE RK E
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAMVTSLE----ESLNKEKQVTEE---VRKNIE--VR 993
Query: 591 TDSCIQFQTDSLGYCGENKEKKLL-MFKRVQEAEDKWRGAQALIEQIKATFSEKEKELEN 649
+FQT EKKL+ + K QE +D R A IE ++ SE +K L +
Sbjct: 994 LKESAEFQTQL--------EKKLMEVEKEKQELQDDKRRA---IESMEQQLSELKKTLSS 1042
Query: 650 KLEELKKQQEKELFKLNQDNYIL-----QAKLSSFEETNKKQRWLHFGEAADPVTGEKLK 704
E+++ ++ L+ + QAK++ E NK +R L AAD E L+
Sbjct: 1043 VQNEVQEALQRASTALSNEQQARRDCQEQAKIA-VEAQNKYERELML-HAADV---EALQ 1097
Query: 705 QIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQS--------LFSEV 756
++++ + ++ Q ++ ++ +Q+ + + + + ERM K+ S L +
Sbjct: 1098 AAKEQVSKMASVRQHLEETTQKAESQLLECKA-SWEERERMLKDEVSKCVCRCEDLEKQN 1156
Query: 757 ASLKEQMHK--SRFLSQVVEDSEPTRNQNFTD-------LLAELRMAQKEKD-------- 799
L +Q+ K + ++ V E + N + ++ +L LR ++EK+
Sbjct: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV 1216
Query: 800 SLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTG---------EKLYEIKILEET 850
+ +E + R +Q + LE + ++++ + ++++ +K + ++ ET
Sbjct: 1217 AQVESL-RYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET 1275
Query: 851 HK---QEISRLQKRLQWYAENQELLDKDALRLREANEEIEK-----------LKLEIEKL 896
+K +E RL++ LQ L+ D L L+EAN E+ + L+ ++++
Sbjct: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW 1335
Query: 897 KAESGNPSIRQKIR--------LKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALIL 948
KA + + +QK L +K K+IQ L ++ G LK +
Sbjct: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEI----GRLKAE---------I 1382
Query: 949 AASAAGDTVDKNTVEFMEKRIKKLEADLEG--KDEDAK--------KSLRTMEQQFQKMK 998
A S A T ++N ++ +++ + K+ + E KD DAK K++ +++ ++ K
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Query: 999 IQYEQRLEQQEQLL---ACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQ 1055
QYE+ QQ++++ A H + +E+ ++KE T+ E + L+ Q
Sbjct: 1443 TQYEELKAQQDKVMETSAQSSGDHQEQHVSV--QEMQELKE----TLNQAETKSKSLESQ 1496
Query: 1056 NAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR 1115
L ++K+ E + + + V+L EL+ ++++QD + E+L
Sbjct: 1497 VENLQKTLSEKE----------TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL---- 1542
Query: 1116 RMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQE 1175
R ++ + K R+ + A AK + H + G D ++ +E
Sbjct: 1543 RQQITEKEEKTRKAIVA--AKSKIAHLA--------GVKD---------------QLTKE 1577
Query: 1176 NYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC 1235
N LK L +K+EL ++ A+ +Q+E + R++ + H +R +E+
Sbjct: 1578 NEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH-------QERHLEQ--- 1627
Query: 1236 QNAVENSSSKVAELNRKI 1253
++ + S+KV E R+I
Sbjct: 1628 RDEPQEPSNKVPEQQRQI 1645
Score = 108 bits (269), Expect = 5e-23
Identities = 235/1312 (17%), Positives = 539/1312 (41%), Gaps = 179/1312 (13%)
Query: 142 LTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEELAENYSDDFEDEY 201
L ++ R+NK LD + + +A A + + E + ++ + S E
Sbjct: 410 LLEKLENKRINKYLD-------EIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
Query: 202 VGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKIT 261
+D + +K++S E+ + + + K VLL L+ ++ ++++
Sbjct: 463 KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
Query: 262 PKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGD---EDKQKIESNTVED 318
+ +E+ + ++ +++ +Q LG+ ++Q+ S+ + +
Sbjct: 523 SADIS----SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578
Query: 319 IKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRI---DSFGIS----GFDLQPVSS 371
++ ++ E E+ K+ + ++ RI + G++ L VS
Sbjct: 579 LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL 638
Query: 372 EKVAERKETEFFSSLPLKMNPNILSQDS--------QHVNLFFDKNDENVILQKTTNESM 423
+R T S P + P I S ++ Q +F + E +K NE +
Sbjct: 639 ASTPKRPSTSQTVSTPAPV-PVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
Query: 424 ENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMG 483
E QVT++ + + L+ K+ + ++ + YR +++S E
Sbjct: 698 EKLQEQVTDLRSQNTKISTQ-LDFASKRYEMLQDNV-------EGYRREITSLHERNQKL 749
Query: 484 KQVPYKKARSAPPL---LKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK 540
K+ + + L+ + A VR+ K LK+ + E ++ +
Sbjct: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ 809
Query: 541 NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLS-TRKKSENPTET-------- 591
+++ +N + IL ++ L K E +S +KK EN E
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869
Query: 592 -----DSCIQFQTDSLGYCG-----ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFS 641
D+ Q T++ + +N +K++ K+ + +Q+ K S
Sbjct: 870 DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
Query: 642 EKEKELENKLEELKKQQE-----KELFKLNQDNYI-LQAKLSSFEETNKKQRWLHFGEAA 695
KE ++++ + +L++ +E KE K + N QA ++S EE+ K++
Sbjct: 930 NKE-DVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK-------- 980
Query: 696 DPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSE 755
VT E K I+ ++E +++ + + ++LQ+ ++ E M ++ L
Sbjct: 981 -QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKT 1039
Query: 756 VASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQAL 815
++S++ ++ ++ + +E Q D + ++A + ++ ++ D +AL
Sbjct: 1040 LSSVQNEVQEALQRASTALSNE---QQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 816 EVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLD-- 873
+ AK+Q++ + + + + E T K E L+ + W + L D
Sbjct: 1097 QA-----------AKEQVSKMASVRQH---LEETTQKAESQLLECKASWEERERMLKDEV 1142
Query: 874 -KDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIR------LKDKAADAKKIQDLER 926
K R + ++ L +IEKL ++ S+++ ++ L ++ ++I ++ R
Sbjct: 1143 SKCVCRCEDLEKQNRLLHDQIEKL-SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR 1201
Query: 927 QVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKS 986
++ + I + R+ + + VE +E+ +++L+ L + E + +
Sbjct: 1202 FIRREKEIAETRFE---------VAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252
Query: 987 LRTMEQQFQKMK--------IQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAH 1038
+TM Q + MK ++ + L ++++ L L Q + +++ LE ++ ++EA+
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA-KVRKLELDILPLQEAN 1311
Query: 1039 ----------QITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
Q + LE ++ K +N L ++ D D E+++ + ++ H K ++
Sbjct: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL-LSEKEVHTK-RIQ 1369
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQN--SKGREEMSAKRAKKDVLHSSKGN 1146
+L EE+ K EI + + +NQN +E+++ R +K+ +
Sbjct: 1370 QLTEEIGRLKAEIA----------RSNASLTNNQNLIQSLKEDLNKVRTEKETIQKD--- 1416
Query: 1147 ANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFEN 1206
LD+K+ + +++V + R K + E ELK + + VM E
Sbjct: 1417 -------LDAKIIDIQEKVKT-ITQVKKIGRRYKTQYE-------ELKAQQDKVM---ET 1458
Query: 1207 SMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSS--SKVAELNRKIATQEVLIRHFQ 1264
S + + H++ +E+++ L Q ++ S S+V L + ++ +E R+ Q
Sbjct: 1459 SAQSSGDHQEQHVS---VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ 1515
Query: 1265 SQVNELQSK----QESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVG----LE 1316
Q +LQS+ ++ L +EE L+++IT+ E+ R+A ++ H G L
Sbjct: 1516 EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 1317 KKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEK 1368
K+ ++++ R+ +Q+ ++ + + + + + L + + R LE+
Sbjct: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQ 1627
Score = 100 bits (249), Expect = 1e-20
Identities = 168/803 (20%), Positives = 341/803 (42%), Gaps = 120/803 (14%)
Query: 631 ALIEQI--KATFSEKEKELENKLEELKKQQEKEL--FKLNQDNYILQAKLSSFEETNKKQ 686
A+++Q+ + ++ K ++NKLE+ Q+ E+ K + + ++++ FE ++
Sbjct: 3 AVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEI---EK 59
Query: 687 RWLHFGEAADPVTGE---------KLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQ 737
R H E T E KL K + E+ L+ Q N + +Q +E+
Sbjct: 60 RLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE 119
Query: 738 NKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKE 797
+ + + + N+ L E+ L E + + L++ +++S T+ + L +L Q
Sbjct: 120 LEAEKRDLIRTNERLSQELEYLTEDVKR---LNEKLKESNTTKGE----LQLKLDELQAS 172
Query: 798 KDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK---LYEIKILEETHKQE 854
S+ KRL+Q+K+ L + E D++ + EK + E+K E K+E
Sbjct: 173 DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232
Query: 855 ISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDK 914
+SRL++++ + E L K L +E ++ + +E+ N I+ K
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
Query: 915 AADAK-KIQDLERQVKEMEGILKR--RYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
A D++ K +L R V+E+ +LK ++ +L + D ++K +E +I +
Sbjct: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE----KIGR 348
Query: 972 LEADLEGKDE----DAKKSLRTMEQQF-----------------QKMKIQYEQRLEQQEQ 1010
LE +LE ++ +K E++ K+ Y +E Q+Q
Sbjct: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
Query: 1011 LLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDED 1070
LL KL K + K LD+I V+ +EA+ +LK Q E ++ +
Sbjct: 409 LLLEKLEN------KRINKYLDEI-------VKEVEAKAPILKRQREEY-----ERAQKA 450
Query: 1071 FQSIEFQVEQAHAKAKLV-----RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSK 1125
S+ ++EQA + + + + N++ + +R+ + + V+ L + R++L
Sbjct: 451 VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME---- 506
Query: 1126 GREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRL------ 1179
EE +D SS ++S S++ H + ++ E+ Q+N RL
Sbjct: 507 -LEEARGNHVIRDEEVSSADISSS------SEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 1180 ------KNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKL 1233
+ E E S+ EL++K E+ + + E +R+ ++ + S+ QR++ ++
Sbjct: 560 LGETREREEQETTSSKITELQLKLESALTELE-QLRKSRQHQMQLVDSI--VRQRDMYRI 616
Query: 1234 LCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITK 1293
L + A ++ R SQ S + V E E I E
Sbjct: 617 LLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT---VSTPAPVPVIESTEAI---EAKA 670
Query: 1294 LLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVE 1353
L++L+E EN+ E K + ++++ Q E+ +Q+ Q T+ + +++
Sbjct: 671 ALKQLQEIFENYKKE---------KAENEKIQNEQLEKLQEQVTDLRSQ--NTKISTQLD 719
Query: 1354 KWKRLAQLKNRELEKFRTELDSI 1376
+ ++ +E +R E+ S+
Sbjct: 720 FASKRYEMLQDNVEGYRREITSL 742
Score = 81.6 bits (200), Expect = 5e-15
Identities = 253/1321 (19%), Positives = 524/1321 (39%), Gaps = 203/1321 (15%)
Query: 124 TLEEQEEKEQFFARLEKGLTSSIDY-----SRLNKELDSNDSTHFKA---LHSNQANAEL 175
T EE E +++ R + L+ ++Y RLN++L +++T + L QA+
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175
Query: 176 TDDEHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPS------------KENSKSEK 223
+ + +EL + ++ ++ L TK +E+ + K N +++K
Sbjct: 176 VKYREKRLEQEKELLHS-----QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
Query: 224 ISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTG---TGV 280
V + EE+ G+ + + L E L + + + + E NE+
Sbjct: 231 EEVSRLEEQMNGLKTSN---EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN 287
Query: 281 SYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESN-TVEDIKSSVK-GHPQENEENSKNIS 338
Y ++ D EA L K+ E+N ++D V+ Q +E + I
Sbjct: 288 LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIG 347
Query: 339 TMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQD 398
+E +L +L+ + +S +L +S A K + L N + +QD
Sbjct: 348 RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 399 SQHVNLFFDKNDENVILQKTTNESMENSCPQVT-EVTATEEHVDKMYLNILRKKITVNSS 457
++L+K N+ + ++ EV A + + R + V S
Sbjct: 408 Q-------------LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASL 454
Query: 458 SLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGK 517
S+ + + + R Q ++ KA +L+R + ++ +
Sbjct: 455 SVKLEQAMKEIQRLQEDTD-------------KANKQSSVLERDNRR---MEIQVKDLSQ 498
Query: 518 PSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTES 577
L M LE+ +I+ + + S S+ E++S
Sbjct: 499 QIRVLLM--ELEEARGNHVIRDEEVSSADISSS---SEVIS------------------Q 535
Query: 578 CLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIK 637
L + + E + + + LG E +E++ K + E + K A +EQ++
Sbjct: 536 HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK-ITELQLKLESALTELEQLR 594
Query: 638 ATFSEKEKELENKL-EELKKQQEKELFKLNQDNYI-LQAKLSSFEE-----TNKKQRWLH 690
K ++ + +L + + +Q++ L+Q + + SS ++ T K+
Sbjct: 595 -----KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQ 649
Query: 691 FGEAADPVT------GEKLKQIQKEIQEQETLLQGYQQENERLYN-QVKDLQEQNKKNEE 743
PV + K K++QE + + ENE++ N Q++ LQEQ
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRS 709
Query: 744 RMFKENQSLFSEVASLKEQMHKSRFLSQVVE-DSEPTRNQNFTDLLAELRMAQKEKDSLL 802
+ K + L + AS + +M + E S RNQ T A + ++ +++
Sbjct: 710 QNTKISTQL--DFASKRYEMLQDNVEGYRREITSLHERNQKLT---ATTQKQEQIINTMT 764
Query: 803 EDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRL 862
+D++ + EV E +KKE++ K ++ V + E + E+ + + + +
Sbjct: 765 QDLRGANEKLAVAEVRAENLKKEKEMLK--LSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 863 QWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQK--------IRLKDK 914
Q E E K L + +IEKL+ EI LK + N + Q+ ++L D
Sbjct: 823 QGILERSETETKQRL-----SSQIEKLEHEISHLKKKLEN-EVEQRHTLTRNLDVQLLDT 876
Query: 915 AADAKKIQDLERQVKEM------EGILKRRYPNSLPALILAASAA----GDTVDKNTVEF 964
+L KE+ E +++ +++ + + S+ G +K V+
Sbjct: 877 KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
Query: 965 MEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRI 1024
+ ++++ E + E K S +EQ +Q M E+ L +++Q+ ++ ++ R+
Sbjct: 937 LVSQLRQTEEQVNDLKERLKTSTSNVEQ-YQAMVTSLEESLNKEKQVTE-EVRKNIEVRL 994
Query: 1025 KA-------LEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQ 1077
K LEK+L ++++ Q + I+ ++ Q +EL + S++ +
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELK--------KTLSSVQNE 1046
Query: 1078 VEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK--DRRMMLSNQNSKGREEMSAKRA 1135
V++A +A NE+ A +R+ Q+ +K Q +R +ML ++ E + A +
Sbjct: 1047 VQEALQRASTALSNEQQA--RRDCQEQAKIAVEAQNKYERELML---HAADVEALQAAKE 1101
Query: 1136 KKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKM 1195
+ + S + + +S+L + + + LK+E+ + +L+
Sbjct: 1102 QVSKMASVRQHLEETTQKAESQLLECKASWE-------ERERMLKDEVSKCVCRCEDLEK 1154
Query: 1196 KSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIAT 1255
++ + +Q E +V +AS+K Q + L + S ++ E+ R I
Sbjct: 1155 QNRLLHDQIEKLSDKV-------VASVKEGVQGPLNVSLSEEG--KSQEQILEILRFIRR 1205
Query: 1256 Q-EVLIRHFQ-SQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFV 1313
+ E+ F+ +QV L+ +Q R E+L++E+ +L + L +E
Sbjct: 1206 EKEIAETRFEVAQVESLRYRQ--------RVELLERELQELQDSLNAERE---------- 1247
Query: 1314 GLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTEL 1373
K++ AQ E EL + + + V+ET + EK + L+ + + + EL
Sbjct: 1248 ----KVQVTAKTMAQHE-ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302
Query: 1374 D 1374
D
Sbjct: 1303 D 1303
Score = 74.7 bits (182), Expect = 6e-13
Identities = 151/782 (19%), Positives = 308/782 (39%), Gaps = 112/782 (14%)
Query: 324 KGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKET--- 380
KG P E+ +S + V +L + ++ + + + S E+ +++
Sbjct: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
Query: 381 EFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHV 440
E ++ +++ + Q L + E LQ ++E+ Q++E+ T V
Sbjct: 985 EVRKNIEVRLKESAEFQTQLEKKLM-EVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV 1043
Query: 441 DKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKR 500
N +++ + S++LS + + + + Q E ++ A L
Sbjct: 1044 Q----NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAA 1099
Query: 501 KPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTS-------------------EDIIKSKN 541
K Q ASVR + + ++ LE K S ED+ K
Sbjct: 1100 KEQVSKMASVRQ--HLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNR 1157
Query: 542 L-----RSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQ 596
L +S KE + G + + K + L ++ + ET +
Sbjct: 1158 LLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVA 1217
Query: 597 FQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEK-----ELENKL 651
Q +SL Y +++ L+ + +QE +D + ++ T ++ E+ E N +
Sbjct: 1218 -QVESLRY----RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVV 1272
Query: 652 EELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQ 711
E K +E +L QD +QAK+ E + A+ EK +Q E +
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPL------QEANAELSEKSGMLQAEKK 1326
Query: 712 EQETLLQGYQQENERLYNQVKD--LQEQNKKNEERMF--KENQSLFSEVASLKEQMHKSR 767
E ++ ++ N+ L +Q KD +E K E+ K Q L E+ LK ++ +S
Sbjct: 1327 LLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARS- 1385
Query: 768 FLSQVVEDSEPTRNQNFTDLLAE-LRMAQKEKDSLLED--------------IKRLKQDK 812
++ T NQN L E L + EK+++ +D I ++K+
Sbjct: 1386 -------NASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIG 1438
Query: 813 QALEVDFEKMKKERDQAKDQIAYVTGE------KLYEIKILEETHKQEISRLQKRLQWYA 866
+ + +E++K ++D+ + A +G+ + E++ L+ET Q ++ K L+
Sbjct: 1439 RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETK-SKSLESQV 1497
Query: 867 EN-QELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLE 925
EN Q+ L + R E+ +L+ E+ +L+ + L+D+ ++ L
Sbjct: 1498 ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQD-----------LQDRTTQEEQ---LR 1543
Query: 926 RQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKK 985
+Q+ E E ++ A++ A S ++ ++ K +L+ ++ +
Sbjct: 1544 QQITEKEEKTRK-------AIVAAKSKIAHLAG------VKDQLTKENEELKQRNGALDQ 1590
Query: 986 SLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNL 1045
++ + +K QYE R+ + E+ L +H R + E ++ QIT++
Sbjct: 1591 QKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTT 1650
Query: 1046 EA 1047
A
Sbjct: 1651 PA 1652
Score = 52.8 bits (125), Expect = 2e-06
Identities = 172/923 (18%), Positives = 349/923 (37%), Gaps = 135/923 (14%)
Query: 7 EELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDF--KDDGLLGTNV 64
E+L+ E K+L ++ + T +++ DT TE + LL
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNL---DVQLLDTKRQLDTETNLHLNTKELLKNAQ 898
Query: 65 SYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDT 124
+ T K ME++ S + K ++ D L ++L +E + L L T
Sbjct: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL-VSQLRQTEEQVNDLKERLKT 957
Query: 125 LEEQEEKEQ-FFARLEKGLTSSIDYS---RLNKELDSNDSTHF------KALHSNQANAE 174
E+ Q LE+ L + R N E+ +S F K + + E
Sbjct: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE 1017
Query: 175 LTDDEHEN-ESKHEELAE------NYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVP 227
L DD+ ES ++L+E + ++ ++ A +E+ ++ + KI+V
Sbjct: 1018 LQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVE 1077
Query: 228 KQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMT---ENEMTGTGVSYGQ 284
Q + + ++ + +++L + E + K+ + L E T E+++ S+ +
Sbjct: 1078 AQNKYERELMLHAADVEALQAAKE----QVSKMASVRQHLEETTQKAESQLLECKASWEE 1133
Query: 285 SSSDV-EALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMES- 342
+ + + + C E + ++ + +E + V +E + N+S E
Sbjct: 1134 RERMLKDEVSKCVCRCEDL---EKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEG 1190
Query: 343 -DLPTVEELMKPIRIDS-FGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQ 400
+ E+++ IR + + F++ V S + +R E L+ + N + Q
Sbjct: 1191 KSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ 1250
Query: 401 HVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLS 460
+++E + +T N ME + E E+ + +M + +K+ ++ L
Sbjct: 1251 VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKV--RKLELDILPLQ 1308
Query: 461 QDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRK-PQSGLYASVRSSGYGKPS 519
+ + L +E++ ++ + V KAR+ + ++K P + Y
Sbjct: 1309 EANAELSEKSGMLQAEKK--LLEEDVKRWKARNQHLVSQQKDPDTEEY------------ 1354
Query: 520 SPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCL 579
K SE + +K ++ ++ K EI A+L + +S
Sbjct: 1355 ---------RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSN-----ASLTNNQNLIQSLK 1400
Query: 580 STRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKAT 639
K ET IQ D+ + K K + K++
Sbjct: 1401 EDLNKVRTEKET---IQKDLDAKIIDIQEKVKTITQVKKIG------------------- 1438
Query: 640 FSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVT 699
+ + + EELK QQ+K + Q + Q + S +E + + L+ E
Sbjct: 1439 -----RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
Query: 700 GEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASL 759
+++ +QK + E+ET + ++LQEQ + + + + Q L + +
Sbjct: 1494 ESQVENLQKTLSEKET--------------EARNLQEQTVQLQSELSRLRQDL-QDRTTQ 1538
Query: 760 KEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDF 819
+EQ+ + Q+ E E TR +++ KD L ++ + LKQ AL
Sbjct: 1539 EEQLRQ-----QITEKEEKTRKA-IVAAKSKIAHLAGVKDQLTKENEELKQRNGAL---- 1588
Query: 820 EKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQ-ELLDKDALR 878
DQ KD++ I L+ ++ ISRL++ L+ + E E D+
Sbjct: 1589 -------DQQKDELD-------VRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
Query: 879 LREANEEIEKLKLEIEKLKAESG 901
+ E+ ++ L+ E G
Sbjct: 1635 SNKVPEQQRQITLKTTPASGERG 1657
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 112 bits (279), Expect = 3e-24
Identities = 210/920 (22%), Positives = 402/920 (43%), Gaps = 128/920 (13%)
Query: 555 EILSGTKLIKPAALDKPAHKTESCLSTRK---KSENPTETDSCIQFQTDSLGYCGENKEK 611
E +S T + A H+ S+R + EN + T + + +T G N K
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG-NASK 492
Query: 612 KLLMFKRVQEAEDKWRGAQALIEQIKATFSE---------KEK-ELENKLEELKKQQEKE 661
L M K Q K + I Q K + KEK +LE +E L++ E++
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 662 LFKLNQDNYILQAKLSSFEETN------------KKQRWLHFGEAADPVTGEKLKQIQKE 709
+ L Q+N L +SS + + K+ + LH + T KL +I+ E
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH---ESIKETSSKLSKIEFE 609
Query: 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNE----------------ERMFKENQSLF 753
++ + L+ Y+++ ER +L K+NE E + +EN L
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 754 SEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLL-----------AELRMAQK--EKDS 800
E LK+ + + L+ +E E +Q + L A ++MAQ E
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 801 LLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQK 860
L + ++LK+ + L+ F+K ER + Q + ++L K LE ++K+ I +L+
Sbjct: 730 LESEKEQLKKGLELLKASFKKT--ERLEVSYQGLDIENQRLQ--KTLENSNKK-IQQLES 784
Query: 861 RLQWYAENQELLDKDALRLREANEEIEKLK------------LEIEKLKAESGNPSIRQK 908
LQ + L K+ L+ +++ +E+L+ LE +K + E N +RQ+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 909 IRLKDKAADAK--KIQDLERQVKEME---GILKRRYPNSLPALILAASAAGDTVDKNTVE 963
+KD + KI +LE++ K + GI Y S L + V + T++
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGI----YKESCVRLKELEKENKELVKRATID 900
Query: 964 FMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPR 1023
K + L DL + K + M +K+ + E+ +E+LL + + DS R
Sbjct: 901 I--KTLVTLREDLVSE----KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDS-R 953
Query: 1024 IKALEKELDD-IKEAHQIT---VRNLEAEIDVLKHQNAEL-----DVKKNDKDDEDFQSI 1074
K LE +L+ +K++ +I + LEA ++ + N +L VKKN + + Q
Sbjct: 954 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 1075 EFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKR 1134
E V+ + ++ E +RE Q+ ++ + ++ KDR + + N+ + E A +
Sbjct: 1014 ERMVQSSPP------ISGEDNKWERESQETTRELLKV-KDRLIEVERNNATLQAEKQALK 1066
Query: 1135 AKKDVLHSSKGNANSFPGTLDSK---LYQPHTFTDSHVSEVLQENYRLKNELEGLISEKN 1191
+ L + N + L + L + +T + +++ EN L ++ L+++
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126
Query: 1192 ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSS--SKVAEL 1249
+L ++ ++ N+ E+ ++ +ED + SL H++ +E L + A E S SK L
Sbjct: 1127 QLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEK-LELLHERQASEYESLISKHGTL 1184
Query: 1250 NRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM 1309
EV R + + N+L ++ L E E++L+ E K+L E +NH
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQL---EDLEKMLKVEQEKMLLE----NKNHETVA 1237
Query: 1310 KHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRL----AQLKN-- 1363
+ L + ++ ++Q +E +++Q H+ +++ N + RL ++LK
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKE-TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296
Query: 1364 RELEKFRTELDSILDVLREL 1383
++L+ T+L++ ++L +L
Sbjct: 1297 QQLDITSTKLNNQCELLSQL 1316
Score = 111 bits (277), Expect = 6e-24
Identities = 203/922 (22%), Positives = 400/922 (43%), Gaps = 198/922 (21%)
Query: 607 ENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEK-ELENKLEELKKQQE---KEL 662
E KE ++ + ED+ G +A +++ EKE +L+ KL +++ +++ K++
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL--EKENLQLKAKLHDMEMERDMDRKKI 405
Query: 663 FKLNQDNYILQ-AKLSSFEETNKKQRWLHFGEAADPV--TGEKLKQIQKEIQEQ-----E 714
+L ++N L+ A+ S +E+ LH G + + T E + QK + +
Sbjct: 406 EELMEENMTLEMAQKQSMDES------LHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 715 TLLQGYQQENERLYNQVKDLQ------EQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
+ L + EN+ L V++L+ E N +M KENQ L +V L+
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE-------- 511
Query: 769 LSQVVEDSEPTRN-QNFT-DLLAELRMAQKEKDSLLED----IKRLKQDKQALEVDFEKM 822
+++V++ + +N QN + DL+ E +K ++L E+ IK L+Q+ + L +
Sbjct: 512 -NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 823 KKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRL----------QKRLQWY---AENQ 869
+ +R Q + EK E KIL E+ K+ S+L +K L+ Y E
Sbjct: 571 R-QRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 870 ELLDKDALRLREANEEIEK----LKLEIEKLKA-ESGNPSIRQKIRLKDKAADAKK---- 920
E L+ + L + NE ++K LK+ EK++A E N + ++ R K D+ K
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 921 -IQDLERQVKEM--EGILKRRYPNSLPALI------------------------------ 947
++ LE++ ++ E + RR SL
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Query: 948 ------LAASAAGDTVD----KNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKM 997
L S G ++ + T+E K+I++LE++L+ D + +T+++ +++
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ----DLEMENQTLQKNLEEL 803
Query: 998 KIQYE--QRLEQQEQLLACKLNQHDSPRIKALEKE----------LDDIKEAHQITVRNL 1045
KI + ++LE++ + L + +Q + + K LEKE D E + + + NL
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDK-KQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 1046 EAEIDVLK-----HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAK-LVRLNEELAAKKR 1099
E E L ++ + + +K+ +K++++ V++A K LV L E+L ++K
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKEL------VKRATIDIKTLVTLREDLVSEKL 916
Query: 1100 EIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLY 1159
+ Q ++ +E+L + + N+ +E S ++ +L S ++ +L+ K
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL--ESTLKKSLEIK-E 973
Query: 1160 QPHTFTDSHVSEVLQENYRLKNEL-------EGLISEKNELKM-KSEAVMNQFENSMRRV 1211
+ ++ + E N +L+ EL E L ++E +M +S ++ +N R
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 1212 KEDTAAHI--------------ASLKASHQ---REIEKLLCQN--------AVENSSSKV 1246
++T + A+L+A Q ++++L QN A++ + +
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1093
Query: 1247 AELNRKIATQEVLIR----HFQSQVNELQSKQESLVVSEVREEILQKEITKLLEEL---- 1298
E N + TQ ++ SQ L ++ L++ + E + + K E+L
Sbjct: 1094 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1153
Query: 1299 ---------------REAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQV 1343
R+A E + KH L+ K +E+ H E Q+++Q Q+
Sbjct: 1154 DSLIKDHEKLELLHERQASEYESLISKHGT-LKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1212
Query: 1344 VETEQNKEVEKWKRLAQLKNRE 1365
+ E+ +VE+ K L + KN E
Sbjct: 1213 EDLEKMLKVEQEKMLLENKNHE 1234
Score = 103 bits (256), Expect = 2e-21
Identities = 185/890 (20%), Positives = 384/890 (43%), Gaps = 146/890 (16%)
Query: 595 IQFQTDSLGYCGENKEKKLLMFKRVQEAE----DKWRGAQALIEQIKATFSEKEKELENK 650
++ +T+ L C + E+ + KR+Q+ R A+ +++ A EK ++
Sbjct: 267 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKL 325
Query: 651 LEELKKQQEK----ELFK-----LNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGE 701
E+ + +E+ E +K L +DN +L + E+ + R +
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR----------ARSD 375
Query: 702 KLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQN---KKNEERMFKENQSL------ 752
KL +++KE + + L + E + ++++L E+N + +++ E+ L
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 753 FSEVASLKEQMHKSRFLSQVVEDSEPTR-------NQNFTDLLAELRMA----------- 794
S + L E KS L V + +R NQ+ T + ELR
Sbjct: 436 ISRTSELSEAPQKS--LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 795 ---QKEKDSLLEDIKRLK----QDKQALE--VDFEK-MKKERDQAKDQIAYVTGEKLYEI 844
+KE L + ++ L+ Q+KQ+L+ + K + KE+ Q + I + +I
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 845 KILEETHK---QEISRLQKRLQWYAE-----------------------------NQELL 872
KILE+ ++ Q +S L++R Q AE + +
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 873 DKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEME 932
K+ +E E E+L+ E+ L+ E N +++KI + +KI+ LE++ E+E
Sbjct: 614 KKELEHYKEKGERAEELENELHHLEKE--NELLQKKI--TNLKITCEKIEALEQENSELE 669
Query: 933 ---GILKRRYPN--SLPALILAASAAGDTVDKNTVEFMEKRIKKLEA------------- 974
LK+ + +L + + +D+ +E + + ++ L+
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE-LRRNVESLKCASMKMAQLQLENK 728
Query: 975 DLEGKDEDAKKSLRTMEQQFQK---MKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKEL 1031
+LE + E KK L ++ F+K +++ Y Q L+ + Q L K ++ + +I+ LE EL
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSY-QGLDIENQRLQ-KTLENSNKKIQQLESEL 786
Query: 1032 DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLN 1091
D++ +Q +NLE E+ + + +L+ K+N +++ +E +Q + K RL
Sbjct: 787 QDLEMENQTLQKNLE-ELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENK--RLR 842
Query: 1092 EELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFP 1151
++ K +++ + + L+K+ + + + K +K+ K
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK------R 896
Query: 1152 GTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENS-MRR 1210
T+D K T + VSE L + ++ N+LE L E ++ + E +++ +++ R
Sbjct: 897 ATIDIKTLV--TLREDLVSEKL-KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 1211 VKEDTAAHIASLKASHQREIEKLLCQNA-VENSSSKVAELNRKIATQEVLIRHFQSQVNE 1269
K + ++LK S + + EK+ A +E S++ +L +++ T + + + +E
Sbjct: 954 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 1270 LQSKQESLVVS------EVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQME 1323
+ Q S +S E + +E+ K+ + L E + N+ L+ ++KQ+E
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Query: 1324 MRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTEL 1373
++ + ++ + +QT V EQN ++ Q++N L T L
Sbjct: 1074 TQNNNLQAQILALQRQT--VSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1121
Score = 94.7 bits (234), Expect = 5e-19
Identities = 161/742 (21%), Positives = 313/742 (42%), Gaps = 115/742 (15%)
Query: 702 KLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKK-----NEERMFKEN------- 749
K++++++E++E+ L +QE E++ ++K LQ++N RM+++
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 750 ----QSLFSEVASLKEQMHKSRFLSQVVEDSEPTRN---QNFTDLLAELRMAQKEKDSLL 802
L SEV+ KE++H F VE+ + + T L +L + D L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 803 EDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRL 862
E L+++ L+ M+ ERD + +I + E + +++ ++ E L L
Sbjct: 379 E----LEKENLQLKAKLHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLHLGWEL 433
Query: 863 QWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQ 922
+ + EL + L E+ +L LK E N S+ K ++
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRL----LKLEMENQSL------------TKTVE 477
Query: 923 DLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDED 982
+L V +EG + IL + K VE +E I + + L+ ++
Sbjct: 478 ELRTTVDSVEGNASK---------ILKMEKENQRLSKK-VEILENEIVQEKQSLQNC-QN 526
Query: 983 AKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITV 1042
K L + Q +K + E+Q ++L + N+H + + +L + EA V
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQE-NEHLNQTVSSLRQRSQISAEAR---V 582
Query: 1043 RNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQ 1102
+++E E +L H++ + K K + F+ + + E H K K R E + E+
Sbjct: 583 KDIEKENKIL-HESIKETSSKLSKIE--FEKRQIKKELEHYKEKGERAEE----LENELH 635
Query: 1103 DLSKTVERLQKD-RRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQP 1161
L K E LQK + ++ + + E+ +++ +++ TLDS ++
Sbjct: 636 HLEKENELLQKKITNLKITCEKIEALEQENSELEREN---------RKLKKTLDS--FKN 684
Query: 1162 HTFT----DSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMN-QFENSMRRVKEDTA 1216
TF + S++ +EN L+ +E L + +KM + N + E+ ++K+
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESL--KCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 1217 AHIASLKASHQRE-------IEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNE 1269
AS K + + E IE Q +ENS+ K+ +L ++ E+ + Q + E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 1270 LQSKQESLVVSEVREEILQKEITKL-------------LEELREAKENHTPEMKHFVG-L 1315
L+ + L E + L++E ++L L + E K+ E +G L
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 1316 EKKIKQME----------MRHAQREQELQQIIQQTHQVVET--EQNKEVEKWKRLAQLKN 1363
EK+ K + +R + E+E ++++++ ++T +++ K Q N
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 1364 RELEKFRTELDSI-LDVLRELH 1384
+LEK EL+ I L+ R LH
Sbjct: 923 NDLEKLTHELEKIGLNKERLLH 944
Score = 77.0 bits (188), Expect = 1e-13
Identities = 246/1160 (21%), Positives = 457/1160 (39%), Gaps = 208/1160 (17%)
Query: 122 LDTLEEQEEKEQFFARLEK---GLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELT-- 176
LD +E E+ E RL++ L S +R+ + D D+ KA+ ++ +E++
Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYR--DELDALREKAVRVDKLESEVSRY 332
Query: 177 ----DDEHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEE 232
D +++ EEL E D V T E+ ++S+K+ E E
Sbjct: 333 KERLHDIEFYKARVEELKE-------DNQVLLETKTMLEDQLEGTRARSDKL----HELE 381
Query: 233 KTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEAL 292
K + L D E+ D K + E+ E MT + Q S E+L
Sbjct: 382 KENLQLKAKLHDM-----EMERDMDRKK------IEELMEENMT---LEMAQKQSMDESL 427
Query: 293 HQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMK 352
H LG E +Q ++ + + GH + NE S + +E + ++ + ++
Sbjct: 428 H---------LGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMENQSLTKTVE 477
Query: 353 PIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHV----NLFFDK 408
+R + G + + EK +R S +++ N + Q+ Q + NL D
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRL------SKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 409 NDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLN---------------------I 447
E L+KT ENS Q+ + EH+++ + I
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 448 LRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYK--KARSAPPLLKRKPQSG 505
L + I SS LS+ + + + +L +E +++ + LL++K +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 506 LYASVRSSGYGKPSSPLK------------------MFSTLEKKTS----EDIIKSKNLR 543
+ + +S L+ +LEK+ S E++ +N+
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 544 SISTSN------QPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQF 597
S+ ++ Q KE+ S + +K E ++ KK+E + +
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGL--------ELLKASFKKTERLEVSYQGLDI 763
Query: 598 QTDSLGYCGENKEKKLLMFK-RVQEAEDKWRGAQALIEQIKATFSEKEK-ELENK----- 650
+ L EN KK+ + +Q+ E + + Q +E++K + E+ E ENK
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 651 ---LEELKKQQEKELFKLNQDNYILQA-------KLSSFEETNK---------KQRWLHF 691
LE+ KKQ EKE +L Q I K+ + E+ NK K+ +
Sbjct: 824 TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883
Query: 692 GEAADPVTGEKLKQIQKEIQEQETLLQGYQQEN---ERLYNQVKDLQEQNKK---NEERM 745
E + E +K+ +I+ TL + E +++ N ++ L + +K N+ER+
Sbjct: 884 KEL-EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Query: 746 FKENQS--------LFSEVAS-LKEQMH-KSRFLSQVVEDSEPTRNQNFTDLLAELRMAQ 795
+ QS L S++ S LK+ + K ++ + E + N N L EL+ +
Sbjct: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN-QQLRQELKTVK 1001
Query: 796 KEKDSLLE--DIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQ 853
K ++L + D +R+ Q + + K ++E + ++ V ++L E++ T +
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK-DRLIEVERNNATLQA 1060
Query: 854 EISRLQKRL-QWYAENQEL------LDKDALRLREANEEIE--KLKLEIEKLKAESGNPS 904
E L+ +L Q +N L L + + L+E N ++ KL++E S + S
Sbjct: 1061 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
Query: 905 I-RQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLP---ALILA----ASAAGDT 956
+ Q +L + + + + E +KE E LK Y + + L L AS
Sbjct: 1121 LMNQNAQLLIQQSSLEN--ENESVIKERED-LKSLYDSLIKDHEKLELLHERQASEYESL 1177
Query: 957 VDKN-TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQ------- 1008
+ K+ T++ K ++ DLE + K +E + +K++ E+ L +
Sbjct: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
Query: 1009 -EQLLAC----KLNQHDSPRIKALE------KELDDIKEAHQITVRNLEAEIDVLKHQNA 1057
E C +LN S +K E K L + ++ LEAE LK Q
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1297
Query: 1058 ELDV--KKNDKDDEDFQSIEFQVEQAHAK-----AKLVRLNEELAAKKREIQDLSKTVER 1110
+LD+ K + E ++ +E+ + L+ N L + E +DL +R
Sbjct: 1298 QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1357
Query: 1111 LQKDRRMMLSNQNSKGREEM 1130
D+ L Q K E++
Sbjct: 1358 QYIDKLNELRRQKEKLEEKI 1377
Score = 68.2 bits (165), Expect = 5e-11
Identities = 182/950 (19%), Positives = 357/950 (37%), Gaps = 122/950 (12%)
Query: 63 NVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELN-HSSLGVG 121
N S KT + + ++ E +A KI ++ L + NE+V + + + +
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 122 LDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
D ++E+ + E+ L + I E + + + A A + D E E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 182 NESKHEELAENYSD----DFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML 237
N+ HE + E S +FE + L E+ E ++E + K+ E +
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 238 ANV-VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAY 296
N+ + + ++++ + N + E ++ T S+ + +E+L +
Sbjct: 649 TNLKITCEKIEALEQENSEL------------ERENRKLKKTLDSFKNLTFQLESLEKEN 696
Query: 297 CHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQ---ENEENSKNISTMESDLPTVEELMKP 353
+ DE+ ++ N VE +K + Q EN+E ++ L ++ K
Sbjct: 697 SQL-----DEENLELRRN-VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Query: 354 IRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENV 413
G D++ +K E + L ++ QD + N KN E +
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKI-QQLESEL------QDLEMENQTLQKNLEEL 803
Query: 414 ILQKTTNESMENSCPQVTEVTATEEHVDKMYLNI----LRKKITVNSSSLSQD------- 462
+ E +E + + T+ E DK L LR++ + ++L ++
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEK-DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 463 DKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKP-QSGLYASVRSSGYGKPSSP 521
+K NKT ++ +E V K++ + L+KR ++R +
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKE----LVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 522 LKMFSTLEKKTSE----DIIKSKNLRSISTSNQPRKKEILSGT----------KLIKPAA 567
+M + LEK T E + K + L +++ R K + S K K AA
Sbjct: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978
Query: 568 LD-----------------KPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKE 610
L+ K K L R+ E ++ I + + +
Sbjct: 979 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1038
Query: 611 KKLLMFK-RVQEAEDKWRGAQALIEQIKATFSEKEKELEN-------------KLEELKK 656
++LL K R+ E E QA + +K + E + N L+E
Sbjct: 1039 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1098
Query: 657 QQEKELFKLNQDNYILQAKLSSFEETNKK----QRWLHFGEAADPVTGEKLKQIQ----K 708
+ + KL +N L ++ +S N + Q L + E LK + K
Sbjct: 1099 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
Query: 709 EIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRF 768
+ ++ E L + E E L ++ L+ +K N E ++ + ++++ K Q+
Sbjct: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHK-NLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMK----- 823
+ +V ++ N+N + AE + E D L +L ++ + L+ D + +K
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1277
Query: 824 KERDQAKDQIAYVTGEKLYEIKILEETHKQE----ISRLQKRLQWYAENQELLDK----- 874
+ +Q + + + ++ Y+ + T +S+L+ L+ EN+ LLD+
Sbjct: 1278 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE--EENRHLLDQIQTLM 1335
Query: 875 -DALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQD 923
L E N E + L ++ + N RQK +L++K D K D
Sbjct: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1385
Score = 67.8 bits (164), Expect = 7e-11
Identities = 96/435 (22%), Positives = 193/435 (44%), Gaps = 49/435 (11%)
Query: 976 LEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD-SPRIKALE---KEL 1031
++G D D K ++ Q+ ++ + + + ++Q D P +K + K L
Sbjct: 145 IQGLDFDTKAAVAAHIQEVT----HNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRL 200
Query: 1032 DDIKEAHQITVRNLEAEID---VLKHQNAELDVKKNDKDDEDFQSIE-FQVEQAHAKAKL 1087
D ++ H T+ L E D L H ++ + +S + VE A AKAK+
Sbjct: 201 IDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKI 260
Query: 1088 VRLNEELAAK-------KREIQDLSKTVERLQKDRRMMLSNQNSKG--REEMSAKRAKKD 1138
RL +EL K K+E++ + ++RLQ++ +LS+ S R+E+ A R K
Sbjct: 261 RRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV 320
Query: 1139 VLHSSKGNANSFPGTL-DSKLYQPHTFTDSHVSEVLQE-NYRLKNELEGLIS-------- 1188
+ + + + L D + Y+ ++VL E L+++LEG +
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380
Query: 1189 EKNELKMKSEAVMNQFENSMRRVK-EDTAAHIASLKASHQREIEKLLCQNAVENSSSKVA 1247
EK L++K++ + E M R K E+ +L+ + ++ +++ L + ++
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL------HLGWELE 434
Query: 1248 ELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTP 1307
+++R E + +VNEL S + ++ E+ + +TK +EELR ++
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 1308 EMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELE 1367
+ +EK+ R +++ + L+ I Q Q ++ QN + K AQL+ + +E
Sbjct: 489 NASKILKMEKE----NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE-KTIE 543
Query: 1368 KFRTELDSILDVLRE 1382
R + + +L +
Sbjct: 544 TLRENSERQIKILEQ 558
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 111 bits (277), Expect = 6e-24
Identities = 199/916 (21%), Positives = 392/916 (42%), Gaps = 116/916 (12%)
Query: 550 QPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETD-SCIQFQTDSLGYCGEN 608
+ R+K + +K+ + L + ES L K + T+ + + + + C E
Sbjct: 86 ETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEA 145
Query: 609 K--EKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLN 666
+ ++ + M + V+E K+ Q++ F + ++ L+ +++ +EL K
Sbjct: 146 QHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQ 205
Query: 667 QDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQ-EQETLLQGYQQENE 725
QD+ +S + +K LH E E L ++ +E++ E++ L++ Y+ +
Sbjct: 206 QDHS------ASVNKGQEKAEELHRMEV------ESLNKMLEELRLERKKLIEDYEGK-- 251
Query: 726 RLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFT 785
N+ + E+ E K +Q +E SL+ K L + + E +
Sbjct: 252 --LNKAQSFYER----ELDTLKRSQLFTAE--SLQASKEKEADLRKEFQGQEAILRKTIG 303
Query: 786 DLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKD-QIAYVTGEKLYEI 844
L EL+M Q E SLL+ ++L+ E + + ++K+ D AK+ ++A ++ K E
Sbjct: 304 KLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVES 363
Query: 845 KI--LEETHKQEISRLQKR------LQWYAENQELLDKD-ALRLREANEEIEKLKLEIEK 895
++ E +Q+ S L + LQ QE+ KD NE + +L+ E
Sbjct: 364 ELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAF 423
Query: 896 LKAESGNPSIRQK---IRLKDKAADAKKIQD--LERQVKEMEGILKRR-------YPNSL 943
L++++ + QK + L+ K +AK+ Q ER++K ++ L+ + +L
Sbjct: 424 LRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL 483
Query: 944 PALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQ 1003
L A + V N + + KKL+ DLE + K +L ++ K Q +Q
Sbjct: 484 EELAWKHHMAIEAVHSNAI----RDKKKLQMDLEEQHNKDKLNL-------EEDKNQLQQ 532
Query: 1004 RLEQQEQLLACKLNQ------HDSPRIKALEKEL---DDIKEAHQITVRNLEAEIDVLKH 1054
LE +++L KLN H ++ E+ L + + + Q + L+ E+D+ K
Sbjct: 533 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 592
Query: 1055 -----QNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKRE--IQDLSKT 1107
++A L+V+ + + + K K+ ++ +L K E Q+ SK
Sbjct: 593 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKL 652
Query: 1108 VERL----QKDRRMMLSN-QNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPH 1162
E L ++D++ +S K RE+ +A+ + + + + L+ +L Q
Sbjct: 653 REELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQ 712
Query: 1163 TFTDSHVSEVLQENYRLKNELEGLISEKNELKMKS---------EAVMNQFENSMR---- 1209
T ++ QE RL ELE L E+++ + KS + + + E R
Sbjct: 713 TSLQQLQAQFTQERQRLTQELEEL-EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN 771
Query: 1210 RVKEDTAAHIASLKASHQREIEKLLCQNAVENS--------------SSKVAELNRKIAT 1255
+++ +A + SLK +H+ +E + E +S +ELN + A
Sbjct: 772 HLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAA 831
Query: 1256 QEVLIR--HFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEM-KHF 1312
L+R H Q + S+ +S + + IT L EELR +E+H E+ K
Sbjct: 832 AIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRH-REHHISELDKEV 890
Query: 1313 VGLEKKIKQMEMRHAQREQELQQIIQQTHQVV---ETEQNKEVEKWKRLAQLKN-RELEK 1368
L + I + + +E+ +I +++Q + E + NK +EK + + RE
Sbjct: 891 QHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNI 950
Query: 1369 FRTELDSILDVLRELH 1384
R + + ++L+E++
Sbjct: 951 MRADFNKTNELLKEIN 966
Score = 55.5 bits (132), Expect = 4e-07
Identities = 105/532 (19%), Positives = 232/532 (43%), Gaps = 90/532 (16%)
Query: 879 LREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRR 938
L++A+EE EI+++ AE+ ++ K ++ ++ +KIQ LE +++ + ++
Sbjct: 72 LKDAHEE------EIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
Query: 939 YPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMK 998
E + R++ ++ E + + + TM ++ ++++
Sbjct: 126 L--------------------TEFEAYKHRVEDMQLCAEAQH---VQRIVTMSREVEEIR 162
Query: 999 IQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAE 1058
++E++L QL Q + + ALE D++ AH+ ++ L + Q+
Sbjct: 163 RKFEEKLRSFGQLQV----QFEKDKRLALE----DLQAAHRREIQEL-----LKSQQDHS 209
Query: 1059 LDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQD----LSKTVERLQKD 1114
V K + E+ +E VE + + +RL +K+ I+D L+K +++
Sbjct: 210 ASVNKGQEKAEELHRME--VESLNKMLEELRLE-----RKKLIEDYEGKLNKAQSFYERE 262
Query: 1115 RRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQ 1174
+ +Q ++K + D+ +G T+ KL +L
Sbjct: 263 LDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTI-GKLKTELQMVQDEAGSLLD 321
Query: 1175 ENYRLKNELEGLISEKN-ELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKL 1233
+ +L+ L I+E N ++ K + E ++ ++ + +A+ + Q++ L
Sbjct: 322 KCQKLQTAL--AIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDL 379
Query: 1234 LCQNAVENSSSKVAELNRKIATQEVLIRHFQSQ---VNE-----------LQSKQESLVV 1279
+ + +S + L TQEV I+ +S+ VNE L+SK +SL
Sbjct: 380 VLK------ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSL-D 432
Query: 1280 SEVREEILQKEITKLLEELREAKENHTPEMKHFVG-LEKKIKQMEMRHAQREQELQQIIQ 1338
E +++IL+ E K+ E R +E + E+K+ LE+++ Q+ H+ + L+++
Sbjct: 433 EEQKQQILELE-KKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS---KTLEELAW 488
Query: 1339 QTHQVVETEQNKEVEKWKR----LAQLKNRE---LEKFRTELDSILDVLREL 1383
+ H +E + + K+ L + N++ LE+ + +L L+ L+E+
Sbjct: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 540
Score = 49.3 bits (116), Expect = 3e-05
Identities = 139/774 (17%), Positives = 291/774 (37%), Gaps = 87/774 (11%)
Query: 86 KIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEEKEQFFARLEKGLTSS 145
++Q ++ SLL L ++E N L LD + +E E K + S
Sbjct: 308 ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD---DAKEGEMALLSKHKEVESE 364
Query: 146 IDYSRLNKELDSND----STHFKALHSNQANAELTDDEHENESKHEELAENYSDDFEDEY 201
+ +R + ++D ++H L + Q E+T + E+E
Sbjct: 365 LAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR--------------- 409
Query: 202 VGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKIT 261
V L+ +EE + +S+ S+ ++++++ +L+ V E +Q+
Sbjct: 410 VNERLSQLEEE---RAFLRSKTQSLDEEQKQQ--------ILELEKKVNEAKRTQQEYYE 458
Query: 262 PKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKS 321
+ + L E E+T ++ ++ ++ H HS DK+K++ + E
Sbjct: 459 RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 518
Query: 322 SV------KGHPQENEENSKNISTMESDLPTVEE----LMKPIRIDSFGISGFDLQPVSS 371
K Q+ EN K + +E L T + L +R G+ + S
Sbjct: 519 DKLNLEEDKNQLQQELENLKEV--LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 576
Query: 372 EKVAERKETEF-FSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQV 430
+ ER + E + LK + L + +++E + K + +
Sbjct: 577 QDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHD 636
Query: 431 TEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGK-QVPYK 489
E+ TE + + LR+++ + +D K + QL E+ A Q +
Sbjct: 637 LEIKWTENL--RQECSKLREELRLQH---EEDKKSAMSQLLQLKDREKNAARDSWQKKVE 691
Query: 490 KARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSN 549
+ LLK+ + L S S + + T E ++ L + +
Sbjct: 692 DLLNQISLLKQNLEIQLSQSQTS-----------LQQLQAQFTQERQRLTQELEELEEQH 740
Query: 550 QPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENK 609
Q R K L ++ +++ K + L + ++ E S +S+
Sbjct: 741 QQRHKS-LKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEM 799
Query: 610 EKKLLMFKRVQEAEDKWRGAQ----------ALIEQIKATFSEK----EKELENKLEELK 655
E++L + E E K A A I+ ++ ++ + ELE ++ +
Sbjct: 800 EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 859
Query: 656 KQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAA----DPVTGEKLKQIQKEIQ 711
+Q ++ + ++ L+ + E +K+ + LH +A G+++ +I+ E
Sbjct: 860 RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESN 919
Query: 712 EQETLLQGYQQENERLYNQVKDLQEQNKKNEERM---FKENQSLFSEVASLKEQMHKSRF 768
+Q L + Q N+RL ++ + + + + M F + L E+ + + +
Sbjct: 920 QQIRLHE--QDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEME 977
Query: 769 LSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKM 822
++ +S+P Q T+L A L + L+ED K + + E +F K+
Sbjct: 978 EKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKV 1031
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/216 (23%), Positives = 98/216 (45%), Gaps = 31/216 (14%)
Query: 1188 SEKNELKM-KSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQ--NAVENSSS 1244
S++ LKM K A + + ++ ++ + I +LK +H+ EI+++L + + S
Sbjct: 37 SQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKS 96
Query: 1245 KVAE---LNRKIATQEVLIRHFQSQVNELQSKQESLVVSEV---REEILQ--------KE 1290
KV E L RKI E S + ++ KQ++L E R E +Q +
Sbjct: 97 KVTEELDLRRKIQVLE------SSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQR 150
Query: 1291 ITKLLEELREAKENHTPEMKHFVGLEKKIKQ-----MEMRHAQREQELQQII--QQTHQV 1343
I + E+ E + +++ F L+ + ++ +E A +E+Q+++ QQ H
Sbjct: 151 IVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSA 210
Query: 1344 -VETEQNKEVEKWKRLAQLKNRELEKFRTELDSILD 1378
V Q K E + + N+ LE+ R E +++
Sbjct: 211 SVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIE 246
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 110 bits (276), Expect = 7e-24
Identities = 263/1371 (19%), Positives = 569/1371 (41%), Gaps = 238/1371 (17%)
Query: 140 KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESK----HEELAENYSD 195
K LT +D L K T + L + N ++ + ++ +K H+EL +++ +
Sbjct: 72 KALTERLDALLLEKA-----ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126
Query: 196 DFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSL-------DS 248
YV K+E M + +K ++ KQ EE M + L + L D+
Sbjct: 127 -----YVKEIENLKNELMAVRSKYSEDKANLQKQLEE--AMNTQLELSEQLKFQNNSEDN 179
Query: 249 VAEVNLDEQDKITP----KPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLG 304
V ++ +E +KI P + L + + + Q + +EA Q Y +SL
Sbjct: 180 VKKLQ-EEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQ 238
Query: 305 DEDKQ--KIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGIS 362
+E Q I V+++ ++ +E+E ++ ++ E L+K
Sbjct: 239 EELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK------ENLVK---------- 282
Query: 363 GFDLQPVSSEKVAERK-ETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNE 421
Q +SEK ++K E E + N N QD+Q ++ EN +++ NE
Sbjct: 283 ----QCEASEKNIQKKYECELENLRKATSNAN---QDNQICSILLQ---ENTFVEQVVNE 332
Query: 422 SMENSCPQVTEVTATEEHV--DKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEG 479
+++ + E+ + + + Y+N L+ K+ +++ + +D+ ++ + E
Sbjct: 333 KVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI-KDEFFHEREDLEFKINEL- 390
Query: 480 AVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKS 539
LL ++ Q + ++S G L K+ +
Sbjct: 391 -----------------LLAKEEQGCVIEKLKSELAG-----------LNKQFCYTV--E 420
Query: 540 KNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQT 599
++ R + + + +KEI + E+ LS +K + + F+
Sbjct: 421 QHNREVQSLKEQHQKEI---------------SELNETFLSDSEKEK------LTLMFEI 459
Query: 600 DSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQE 659
L EN +++ QEA + + ++E ++ E ++ + E +K+QQ
Sbjct: 460 QGLKEQCENLQQEK------QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 660 KELFKLNQD-NYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQ 718
++ +L Q K + E N+ Q GE EKL Q+ + E E ++
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQ-----GE------NEKLLSQQELVPELENTIK 562
Query: 719 GYQQENERLYNQVKDLQEQNKKNEER---MFKENQSLFSEVASLKEQM---HK-----SR 767
Q++N + K+ E + + +E +++ + E+M HK R
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREER 622
Query: 768 FLSQVVEDSEPT------RNQNFTDLLAELRMAQKEKD-------SLLEDIKRLKQDKQA 814
+ ++ + E T Q +L L KEKD L+ +K L +DK+
Sbjct: 623 LILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEV 682
Query: 815 LEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEET-HKQEISRLQKRLQWYAENQELLD 873
L + + + +E ++ + ++ + + E+ K+ I++L+K+LQ E Q+ L+
Sbjct: 683 LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN 742
Query: 874 KDALRLREANEEIEKLKLE------IEKLKAESGNPSIRQKI--RLKDKAADAKKIQD-- 923
K L E NE+++KL ++ ++++ +E S + + L+ KI +
Sbjct: 743 K----LLE-NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEK 797
Query: 924 ------LERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLE 977
+ +V E+E +K S+ S D + + + K +++++++ E
Sbjct: 798 CNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL--LRKELEEIQSEKE 855
Query: 978 GKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQL-LACKLNQHDSPRIKALEKELDDIKE 1036
D L M+ +K +++ + L Q E++ C ++ + + K KE +++K
Sbjct: 856 ALQSD----LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKP 911
Query: 1037 -AHQITVRNLEAEIDVLKHQNAELDVKKND------KDDEDFQSIEFQVEQAHAKAKLVR 1089
Q +R+ AE+ +LK A+ KND + +E +++E + ++ K ++
Sbjct: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
Query: 1090 L-----NEELAAKKREIQDLSKTVERLQKDRRMMLSN-----QNSKGREEMSAKRAKK-D 1138
L +EL + ++E Q + + +E L+ ++ + ++ Q ++ + + + K+ +
Sbjct: 972 LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
Query: 1139 VLHSSKGNANSFPGTLD-------SKLYQPHTFTDSHVS-----EVLQENYRLKNELEGL 1186
L K AN+F ++ + Q T + E LQ N +L E++ L
Sbjct: 1032 QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL-EVQIL 1090
Query: 1187 ISEKNELKMKSEAVMNQFENSMRRVKE--DTAAHIASLKASHQRE---IEKLLCQ-NAVE 1240
++ + + E + + +++KE T + L+ Q+E ++K + + V+
Sbjct: 1091 EVQRAKAMVDKELEAEKLQKE-QKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK 1149
Query: 1241 NSSSKVAELNRKIATQEVLIRHFQSQV----NELQSKQESLVVSEVREEILQKEITKLLE 1296
+ + +N +IA E L++ ++ N+++ ++ + + + ++E LQ+EIT L
Sbjct: 1150 KDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Query: 1297 ELREAKENHTPEMKHFVGLEKKI---KQMEMRHAQREQELQQIIQQTHQVVE-------- 1345
+++ +E +T + V +K++ KQ E H + L+ ++ + Q VE
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 1346 --TEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQGVVVPVAF 1394
+E++K E K A+ R L ++ + ++ + R + V F
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
Score = 108 bits (270), Expect = 4e-23
Identities = 307/1492 (20%), Positives = 606/1492 (40%), Gaps = 225/1492 (15%)
Query: 5 SQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNV 64
+ +EL++ ++KE+ + E ++ S+ + + + + + L N
Sbjct: 116 AHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNN 175
Query: 65 SYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELV-----VSELNHSSLG 119
S KK + + +I E+I +L+ L + E E V + E N
Sbjct: 176 SEDNVKKLQEEIEKIRPGFEEQILYLQKQ----LDATTDEKKETVTQLQNIIEANSQHYQ 231
Query: 120 VGLDTLEEQEEKEQFFARLE-KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDD 178
+++L+E+ + + + E K L I+ S E + N K Q A +
Sbjct: 232 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNI 291
Query: 179 EHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQE-------- 230
+ + E + E L + S+ +D + + L ++ + N K + + +E
Sbjct: 292 QKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSIL 351
Query: 231 EEKTGMLANVVLLDSLDSV------------AEVNLDEQDKITPKPRCLPEMTENEMTGT 278
+++ + N+ L +D+ E ++E + C+ E ++E+ G
Sbjct: 352 KDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGL 411
Query: 279 GVSY----GQSSSDVEAL---HQAYCHIAHS--LGDEDKQKIESN-TVEDIKSSVKGHPQ 328
+ Q + +V++L HQ + L D +K+K+ ++ +K + Q
Sbjct: 412 NKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQ 471
Query: 329 ENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPL 388
E +E N ++ + E+++ +S G + + + ++ ++ E L
Sbjct: 472 EKQEAILNYESLRE----IMEILQTELGESAGKISQEFESMKQQQASDVHE------LQQ 521
Query: 389 KMNPNILSQDS--QHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLN 446
K+ +D+ + VN +N E ++ Q+ +EN+ + E +YL
Sbjct: 522 KLRTAFTEKDALLETVNRLQGEN-EKLLSQQELVPELENTIKNLQEKNG-------VYLL 573
Query: 447 ILRKKIT--------VNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLL 498
L ++ T +NS + +DD INK +S EE K+ ++ R L
Sbjct: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLK----NSHEEMDNFHKKCE-REERLILELG 628
Query: 499 KRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILS 558
K+ Q+ Y S + + L+ TL++K D K + + ++ KE+LS
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLE--ETLKEKDQNDQKLEKLMVQMKVLSED--KEVLS 684
Query: 559 GTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKR 618
A K ++ + LS+ KK + Q + L EKKL +
Sbjct: 685 --------AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736
Query: 619 VQEAEDKWRGAQALIEQIKATFSEKE-----KELENKLEELKKQQEKELFKLNQDNYILQ 673
Q+ +K EQ++ F + + KE+ +++ E +EK++ +LQ
Sbjct: 737 EQDNLNKLLEN----EQVQKLFVKTQLYGFLKEMGSEVSE--DSEEKDVVN------VLQ 784
Query: 674 AKLSSFEETNKKQRWLHFGEAADPVTGEK-LKQIQKE----IQEQETLLQGYQQENERLY 728
A S + N+++ L F + EK +K +Q+E +E ++LL+ Y+QE L
Sbjct: 785 AVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844
Query: 729 NQVKDLQEQN----------KKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEP 778
+++++Q + K E+ ENQ+L +V + + KS ++ E
Sbjct: 845 KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK-EKCFI 903
Query: 779 TRNQNFTDLLA--ELRMAQKE----KDSLLEDIKRLKQDK----QALEVDFEKMKKERDQ 828
++N LL ELR + E KDSL + +K D + LE E ++KE +
Sbjct: 904 KEHENLKPLLEQKELRDRRAELILLKDSLAKS-PSVKNDPLSSVKELEEKIENLEKECKE 962
Query: 829 AKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELL--DKDALR-----LRE 881
+ EK+ +IK++ K+E+ +K Q E E L +KD L L +
Sbjct: 963 KE--------EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014
Query: 882 ANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAK-KIQDLERQVKEMEGILKRRYP 940
E + L LE EK +S + K++A + + +I+DL RQ++ L+
Sbjct: 1015 GAESYKNLLLEYEK---QSEQLDVE-----KERANNFEHRIEDLTRQLRN--STLQCETI 1064
Query: 941 NSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQ 1000
NS +LA +E ++ K LE + + +++ ++++ + K+Q
Sbjct: 1065 NSDNEDLLAR-----------IETLQSNAKLLEVQIL----EVQRAKAMVDKELEAEKLQ 1109
Query: 1001 YEQRLEQQEQLLACKLNQHDSPRI------KALEKELDDI----KEAHQITVRNLE-AEI 1049
EQ++++ A +N+ + ++ K L+K + ++ K+A Q T+ N+E A+
Sbjct: 1110 KEQKIKEH----ATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADY 1165
Query: 1050 DVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVE 1109
+ L + + KN+K ++ Q I+ Q K K L EE+ + + +Q E
Sbjct: 1166 ERLMKELNQKLTNKNNKIEDLEQEIKIQ------KQKQETLQEEITSLQSSVQQYE---E 1216
Query: 1110 RLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHV 1169
+ K +++++ + +E +K+A+ D L S G L++ Q + +
Sbjct: 1217 KNTKIKQLLVKTK----KELADSKQAETDHLILQA----SLKGELEASQQQVEVYK-IQL 1267
Query: 1170 SEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQRE 1229
+E+ E +++ L+ + + + + R K + A + S S++
Sbjct: 1268 AEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQAT-VTSEFESYKVR 1326
Query: 1230 IEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQK 1289
+ +L Q +N S AE +E L +LQ Q +L ++ + LQ
Sbjct: 1327 VHNVLKQQ--KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS 1384
Query: 1290 EITKLLE--------------ELREA-----KENHTPEMKHFVGLEKKIKQMEMRHAQRE 1330
E LLE ELRE EN + +H + + Q E+
Sbjct: 1385 EHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR 1444
Query: 1331 QELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRE 1382
+++ + ++ + VET Q + + +L QLKN + L LRE
Sbjct: 1445 DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE 1496
Score = 89.4 bits (220), Expect = 2e-17
Identities = 194/1039 (18%), Positives = 423/1039 (40%), Gaps = 203/1039 (19%)
Query: 514 GYGKPSSPLKMFSTLEKKTSEDIIK-SKNLRSISTSNQPRKKEILSGTKLIKPAALDKPA 572
G P++P S LE ED+IK +K + + R E+ + ++ + +
Sbjct: 8 GVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGT 67
Query: 573 HKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQAL 632
L+ R D+ + + ++ C K++ + M + V+++ K A
Sbjct: 68 GDIIKALTER--------LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE 119
Query: 633 IEQIKATFSEKEKELENKL-------EELKKQQEKELFKLNQDNYIL--QAKLSSFEETN 683
+EQ + ++ + L+N+L E K +K+L + L Q K + E N
Sbjct: 120 LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDN 179
Query: 684 KK--------------QRWLHFGEAADPVTGEKLKQI----------------------- 706
K ++ L+ + D T EK + +
Sbjct: 180 VKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQE 239
Query: 707 ---------QKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFS-EV 756
Q+E++E ++ +E+E N++ +L+E K E K Q + E+
Sbjct: 240 ELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECEL 299
Query: 757 ASLKEQ--------------MHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQ---KEKD 799
+L++ + ++ F+ QVV + + ++ D L EL K++
Sbjct: 300 ENLRKATSNANQDNQICSILLQENTFVEQVVNE----KVKHLEDTLKELESQHSILKDEV 355
Query: 800 SLLEDIK-RLKQDKQALEVDF-------------------------EKMKKERDQAKDQI 833
+ + ++K +L+ D Q ++ +F EK+K E Q
Sbjct: 356 TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQF 415
Query: 834 AYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQEL---------------------- 871
Y + E++ L+E H++EIS L + +E ++L
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 872 --LDKDALR------LREANEEIEKLKLEIEKLKAESGNP--SIRQKIRLKDKAADAKKI 921
L+ ++LR E E K+ E E +K + + ++QK+R DA +
Sbjct: 476 AILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDA-LL 534
Query: 922 QDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFM-----EKRIKKLEADL 976
+ + R E E +L ++ +P L + + +KN V + + +K+LE +
Sbjct: 535 ETVNRLQGENEKLLSQQ--ELVPEL---ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI 589
Query: 977 EGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK---ALEKELDD 1033
E+ + ++ ++M + ++ E++E+L+ +L + I+ LE+++++
Sbjct: 590 NSLTEEKDDFINKLKNSHEEMD-NFHKKCEREERLI-LELGKKVEQTIQYNSELEQKVNE 647
Query: 1034 IKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKD--DEDFQSIEFQVEQAHAKAKLVRLN 1091
+ + T++ + L+ ++ V DK+ + +S+ + + ++ K + +
Sbjct: 648 LTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD 707
Query: 1092 EELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFP 1151
E+ ++E L + + +L+K ++M+ Q++ + + + K V K F
Sbjct: 708 LEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV----KTQLYGFL 763
Query: 1152 GTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRV 1211
+ S++ + DS +V+ + L + EK L + + + + E ++ +
Sbjct: 764 KEMGSEVSE-----DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCL 818
Query: 1212 KEDTAAHIASLKA-SHQREIEKLLCQNAVENSSS------------KVAELNRKIATQEV 1258
+E++ LK+ E EK+L + +E S K A ++ Q +
Sbjct: 819 QEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNL 878
Query: 1259 LIRHFQ-SQV---NELQSKQESLVVSE---VREEILQKEITKLLEELREAKEN--HTPEM 1309
LI+ + SQ +E+ +++E + E ++ + QKE+ EL K++ +P +
Sbjct: 879 LIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
Query: 1310 KH-----FVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNR 1364
K+ LE+KI+ +E ++E+++ +I ++V + KE++ ++ Q
Sbjct: 939 KNDPLSSVKELEEKIENLEKECKEKEEKINKI-----KLVAVKAKKELDSSRKETQTVKE 993
Query: 1365 ELEKFRTELDSILDVLREL 1383
ELE R+E D + +R+L
Sbjct: 994 ELESLRSEKDQLSASMRDL 1012
Score = 86.3 bits (212), Expect = 2e-16
Identities = 234/1265 (18%), Positives = 501/1265 (39%), Gaps = 187/1265 (14%)
Query: 5 SQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNV 64
S ++ +EFE ++ + D E K + +KD + + +++ LL
Sbjct: 497 SAGKISQEFESMKQQQASDVHELQQKL----RTAFTEKDALLETVNRLQGENEKLLSQQE 552
Query: 65 SYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDS-----LETNELVVSELNHSSLG 119
+ + T + ++E++ + L T L + E + +++L +S
Sbjct: 553 LVPELENT---IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH-- 607
Query: 120 VGLDTLEEQ-EEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDD 178
+D ++ E +E+ L K + +I Y N EL+ + L E +
Sbjct: 608 EEMDNFHKKCEREERLILELGKKVEQTIQY---NSELEQKVNELTGGLE------ETLKE 658
Query: 179 EHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSK--SEKISVPKQEEEKTGM 236
+ +N+ K E+L ED+ V + + + +EN+K SEK + + E
Sbjct: 659 KDQNDQKLEKLMVQMKVLSEDKEV----LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714
Query: 237 LANVVL---LDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALH 293
+V+L + L+ ++ ++EQD + ++ ENE +
Sbjct: 715 KEDVILKEHITQLEKKLQLMVEEQDNLN-------KLLENEQV----------QKLFVKT 757
Query: 294 QAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKP 353
Q Y + +G E + E V ++ +V + E N++ + V EL K
Sbjct: 758 QLYGFLKE-MGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE--KVLELEKE 814
Query: 354 IRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENV 413
I+ + E V + +E + +L D E V
Sbjct: 815 IKC------------LQEESVVQCEELK---------------------SLLRDYEQEKV 841
Query: 414 ILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTY-RSQ 472
+L+K E +E A + + +M N K N + L Q +++++T +S+
Sbjct: 842 LLRKELEEIQ-------SEKEALQSDLLEMK-NANEKTRLENQNLLIQVEEVSQTCSKSE 893
Query: 473 LSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKT 532
+ +E+E + + K L R+ + L + + PL LE+K
Sbjct: 894 IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKI 953
Query: 533 SEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETD 592
+NL K+E ++ KL+ A + S+RK+++ E
Sbjct: 954 -------ENLEK----ECKEKEEKINKIKLVAVKA-------KKELDSSRKETQTVKEEL 995
Query: 593 SCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLE 652
++ + D L + + +K + +K + Q +E+ E+ E+++E
Sbjct: 996 ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK-QSEQLDVEK------ERANNFEHRIE 1048
Query: 653 ELKKQQEKELFK---LNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKE 709
+L +Q + +N DN L A++ + + +N K + E + KE
Sbjct: 1049 DLTRQLRNSTLQCETINSDNEDLLARIETLQ-SNAKLLEVQILEVQ-----RAKAMVDKE 1102
Query: 710 IQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFL 769
++ ++ + +E+ N++++LQ Q +K ++++ K Q E+ +K+ ++ +
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQ----ELELVKKDAQQTTLM 1158
Query: 770 SQVVEDSE----------PTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDF 819
+ + D E +N DL E+++ ++++++L E+I L+ Q E
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN 1218
Query: 820 EKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRL 879
K+K+ + K ++A + + IL+ + K E+ Q++++ Y + + ++
Sbjct: 1219 TKIKQLLVKTKKELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277
Query: 880 REANEEIEKLKLEIEK----LKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL 935
E LK E+ L A + Q+ KA A + E + +L
Sbjct: 1278 H------EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 936 KRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQ 995
K++ S+ S A K E +E I +L+ L +D++ +L+ + Q
Sbjct: 1332 KQQKNKSM-------SQAETEGAKQEREHLEMLIDQLKIKL----QDSQNNLQINVSELQ 1380
Query: 996 KMKIQYEQRLEQQEQLLACKLNQHDSPRIK--ALEKELDDIKEAHQITVRNLEAEIDVLK 1053
++ +++ LE+ ++L +++ R K +++ E +K H TV L ++ +VL+
Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR 1440
Query: 1054 HQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQK 1113
N+ D ++ +++ Q + + +A+L +L E + S R ++
Sbjct: 1441 --NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERR 1498
Query: 1114 DRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHT---------- 1163
+ + L + ++ REE S +A+++ +L+ L P T
Sbjct: 1499 NTDLPLLDMHTVTREEGEGMETTDT---ESVSSASTYTQSLEQLLNSPETKLEPPLWHAE 1555
Query: 1164 FTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRV-----KEDTAAH 1218
FT + + L + + L GL+ E + ++ +RR+ +E +AA+
Sbjct: 1556 FTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAAN 1615
Query: 1219 IASLK 1223
+ LK
Sbjct: 1616 LEYLK 1620
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 110 bits (276), Expect = 7e-24
Identities = 178/797 (22%), Positives = 346/797 (43%), Gaps = 114/797 (14%)
Query: 627 RGAQALIEQIKATFSEKEKELENKLEE----------LKKQQEKELFKLNQDNYILQAKL 676
R ++A E+ ++ S + +E+ +LEE L K++E E KL +D L+
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRD---LEEAT 1185
Query: 677 SSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQE 736
E R H A+ GE++ +Q+ Q+ E + E + L + + + +
Sbjct: 1186 LQHEAMVAALRKKHADSMAE--LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243
Query: 737 QNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQK 796
K N E+M + + SE+ + +E+ + ++ D R + T+ E
Sbjct: 1244 A-KGNLEKMCRSLEDQVSELKTKEEEQQR------LINDLTAQRARLQTEA-GEYSRQLD 1295
Query: 797 EKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEIS 856
EKD+L+ + R KQ + + +E +AK+ +A+ ++ +L E +++E
Sbjct: 1296 EKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEE-- 1353
Query: 857 RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAA 916
+ AE Q L K AN E+ + + + E + K +L +
Sbjct: 1354 -----QEGKAELQRALSK-------ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1401
Query: 917 DAKK-IQDLERQVKEMEGILKRRYPNSLPALIL------AASAAGDTVDKNTVEFMEKRI 969
+A++ ++ + + +E K+R N + L+L AA AA D +N + + +
Sbjct: 1402 EAEEHVEAVNAKCASLEKT-KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK 1460
Query: 970 KKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEK 1029
+K E + + + E ++K R++ + K+K YE+ L+Q E L + N++ I L +
Sbjct: 1461 QKYE-ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR--RENKNLQQEISDLTE 1517
Query: 1030 EL-DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV 1088
++ + K+ H++ + E + + Q A L+ + + E+ + + Q+E K+++
Sbjct: 1518 QIAEGGKQIHELEKIKKQVEQEKCEIQ-AALEEAEASLEHEEGKILRIQLELNQVKSEVD 1576
Query: 1089 RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNAN 1148
R ++A K EI L + R+ + M S +++ R A R KK + +G+ N
Sbjct: 1577 R---KIAEKDEEIDQLKRNHTRVVET---MQSTLDAEIRSRNDALRVKKKM----EGDLN 1626
Query: 1149 SFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSM 1208
L+ H + + E+ R +G++ E ++ ++
Sbjct: 1627 EMEIQLN------------HANRLAAESLRNYRNTQGILKE-------TQLHLDDALRGQ 1667
Query: 1209 RRVKEDTAAHIASLKASH-QREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQ--- 1264
+KE A I +A+ Q EIE+L S K+AE A++ V + H Q
Sbjct: 1668 EDLKEQLA--IVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1725
Query: 1265 ---------SQVNELQSKQESLV-VSEVREEILQKEIT---KLLEELREAKEN--HTPEM 1309
+ V++LQS+ E ++ S EE +K IT + EEL++ ++ H M
Sbjct: 1726 LINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1785
Query: 1310 KHFVGLEKKIKQMEMRHAQRE-----------QELQQIIQQTHQVVETEQNKEVEKWKRL 1358
K LE+ +K ++ R + E Q+L+ +++ VE EQ + E K L
Sbjct: 1786 KK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGL 1843
Query: 1359 AQLKNRELE-KFRTELD 1374
+ + R E ++TE D
Sbjct: 1844 RKHERRVKELTYQTEED 1860
Score = 106 bits (264), Expect = 2e-22
Identities = 176/823 (21%), Positives = 344/823 (41%), Gaps = 146/823 (17%)
Query: 641 SEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSF-EETNKKQRWLHFGEAADPVT 699
+E EKE+ EE +K ++ EL K L+ K+ + +E N
Sbjct: 846 AETEKEMATMKEEFQKTKD-ELAKSEAKRKELEEKMVTLLKEKN---------------- 888
Query: 700 GEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASL 759
+Q ++Q + L ++ E+L L+ + K+ ER +E + + +E+ +
Sbjct: 889 -----DLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERA-EEEEEINAELTAK 942
Query: 760 KEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDF 819
K ++ ED ++ DL L +KEK + +K L ++ L+
Sbjct: 943 KRKL----------EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 992
Query: 820 EKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQ---KRLQWYAENQELLDKDA 876
K+ KE+ K L+ETH+Q + LQ ++ + + L++
Sbjct: 993 AKLSKEK------------------KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV 1034
Query: 877 LRLREANEEIEKLKLEIEKLK----------------AESGNPSIRQKIRLKD------- 913
L + E+ +KL++++E+ K E+ + +K+ K+
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094
Query: 914 -KAADAKKIQ-DLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKK 971
K D + ++ L++++KE++ ++ L I A A+ +K + + + +++
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIE-----ELGEEIEAERASRAKAEKQRSD-LSRELEE 1148
Query: 972 LEADLE--GKDEDAKKSL-RTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALE 1028
+ LE G A+ L + E +FQK++ E+ Q E ++A +H + + L
Sbjct: 1149 ISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH-ADSMAELG 1207
Query: 1029 KELDDIKEAHQITVR---NLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK- 1084
+++D+++ Q + L+ E D L NAE K ++ +S+E QV + K
Sbjct: 1208 EQIDNLQRVKQKLEKEKSELKMETDDLS-SNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266
Query: 1085 -----------AKLVRLNEELAAKKREIQDLSKTVERLQKDRR---MMLSNQNSKGREEM 1130
A+ RL E R++ + V +L + ++ + + EE
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 1326
Query: 1131 SAKRAKKDVLHSSKGNAN----SFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGL 1186
AK A L SS+ + + + + K + ++ SEV Q +R K E +
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN-SEVAQ--WRTKYETDA- 1382
Query: 1187 ISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQR---EIEKLLCQNAVENSS 1243
I EL+ + + + + + V E A ASL+ + QR E+E L+ VE S+
Sbjct: 1383 IQRTEELEEAKKKLAQRLQEAEEHV-EAVNAKCASLEKTKQRLQNEVEDLMLD--VERSN 1439
Query: 1244 SKVAELNRKIATQEVLIRHFQSQVNELQSKQES------------LVVSEVRE------E 1285
+ A L++K + ++ ++ + E Q++ E+ V V E E
Sbjct: 1440 AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLE 1499
Query: 1286 ILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVE 1345
L++E L +E+ + E K LEK KQ+E Q + E+Q +++ +E
Sbjct: 1500 TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVE----QEKCEIQAALEEAEASLE 1555
Query: 1346 TEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQGV 1388
E+ K + L Q+K+ E+++ E D +D L+ H + V
Sbjct: 1556 HEEGKILRIQLELNQVKS-EVDRKIAEKDEEIDQLKRNHTRVV 1597
Score = 98.6 bits (244), Expect = 4e-20
Identities = 167/802 (20%), Positives = 353/802 (44%), Gaps = 104/802 (12%)
Query: 576 ESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEK----KLLMFKRVQEAEDKWRGAQA 631
E + T K +N + +Q + DSL E E+ K+ + +++E ++
Sbjct: 877 EEKMVTLLKEKNDLQLQ--VQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-- 932
Query: 632 LIEQIKATFSEKEKELENKLEELKK---QQEKELFKLNQDNYILQAKLSSFEETNKKQRW 688
E+I A + K+++LE++ ELKK E L K+ ++ + + K+ + E
Sbjct: 933 --EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE------ 984
Query: 689 LHFGEAADPVTGEKLKQIQKEIQE--QETL--LQGYQQENERLYNQVKDLQEQNKKNEER 744
A T KL + +K +QE Q+TL LQ +++ + + K EQ + E
Sbjct: 985 ----MAGLDETIAKLSKEKKALQETHQQTLDDLQA-EEDKVNILTKAKTKLEQQVDDLEG 1039
Query: 745 MFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLED 804
++ + L ++ K ++ L+Q +S + L +L + E +L+
Sbjct: 1040 SLEQEKKLRMDLERAKRKLEGDLKLAQ---ESTMDMENDKQQLDEKLEKKEFEISNLISK 1096
Query: 805 IKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQW 864
I +D+QA+E+ +K KE +++ GE++ + +++ S L + L+
Sbjct: 1097 I----EDEQAVEIQLQKKIKELQARIEEL----GEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 865 YAENQELLDKDALRLREANE----EIEKLKLEIEK--LKAESGNPSIRQKIRLKDKAADA 918
+E E E N+ E +KL+ ++E+ L+ E+ ++R+K A
Sbjct: 1149 ISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK-HADSMAELG 1207
Query: 919 KKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEG 978
++I +L+R +++E K + + L+++A + K +E M + ++ ++L+
Sbjct: 1208 EQIDNLQRVKQKLE---KEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 979 KDEDAKKSLRTMEQQFQKMKI---QYEQRLEQQEQLLA--CKLNQHDSPRIKALEKELDD 1033
K+E+ ++ + + Q +++ +Y ++L++++ L++ + Q + +I+ L+ +L++
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324
Query: 1034 IKEAHQITVRNLEA---EIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAK--AKLV 1088
+A L++ + D+L+ Q E K + +V Q K +
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL-QRALSKANSEVAQWRTKYETDAI 1383
Query: 1089 RLNEEL-AAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNA 1147
+ EEL AKK+ Q L + E ++ S + +K R + + DV S
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS----- 1438
Query: 1148 NSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENS 1207
N+ LD K D +SE Q+ + ELE E L + V N +E S
Sbjct: 1439 NAACAALDKK----QRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEES 1494
Query: 1208 MRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQV 1267
+ +++ + +RE + L Q + + + ++AE ++I E + + + +
Sbjct: 1495 LDQLE------------TLRRENKNL--QQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540
Query: 1268 NELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHA 1327
E+Q+ E S EE +I ++ EL + K +++ + A
Sbjct: 1541 CEIQAALEEAEASLEHEE---GKILRIQLELNQVK-----------------SEVDRKIA 1580
Query: 1328 QREQELQQIIQQTHQVVETEQN 1349
++++E+ Q+ + +VVET Q+
Sbjct: 1581 EKDEEIDQLKRNHTRVVETMQS 1602
Score = 80.9 bits (198), Expect = 8e-15
Identities = 197/1101 (17%), Positives = 448/1101 (40%), Gaps = 188/1101 (17%)
Query: 123 DTLEEQEEKEQFFARLE-KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
+ E EE+E+ A L K + S L K++D + T A++ ++H
Sbjct: 924 EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL----------AKVEKEKHA 973
Query: 182 NESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML--AN 239
E+K + L E + + + +E + + + + + + EE+K +L A
Sbjct: 974 TENKVKNLTEEMAG------LDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAK 1027
Query: 240 VVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVE--------A 291
L +D + E +L+++ K+ R E + ++ G +S+ D+E
Sbjct: 1028 TKLEQQVDDL-EGSLEQEKKL----RMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 292 LHQAYCHIAHSLGD-EDKQKIESNT----------VEDIKSSVKGHPQENEENSKNISTM 340
L + I++ + ED+Q +E +E++ ++ + K S +
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 341 ESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQ 400
+L + E ++ ++ G + ++ + +++E EF K+ ++ Q
Sbjct: 1143 SRELEEISERLE----EAGGATSAQVE------LNKKREAEF-----QKLRRDLEEATLQ 1187
Query: 401 HVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLS 460
H + ++ E ++N +V + E+ KM + L S +
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQIDN-LQRVKQKLEKEKSELKMETDDLSSNAEAISKAKG 1246
Query: 461 QDDKINKTYRSQLSS----EEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYG 516
+K+ ++ Q+S EEE + + ++AR + ++G Y S
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARL-------QTEAGEY----SRQLD 1295
Query: 517 KPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTK----LIKPAALDKPA 572
+ + + S ++ +++ I + K+ T + L ++ L++ ++
Sbjct: 1296 EKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE 1355
Query: 573 HKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQAL 632
K E + K + + + +++TD++ E +E K + +R+QEAE+ A
Sbjct: 1356 GKAELQRALSKANSEVAQWRT--KYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 633 IEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFG 692
++ T ++ L+N++E+L E+ N L K +F++
Sbjct: 1414 CASLEKT----KQRLQNEVEDLMLDVERS----NAACAALDKKQRNFDKV---------- 1455
Query: 693 EAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ---VKDLQEQNKKNEERMFKEN 749
L + +++ +E + L+ Q+E+ L + VK++ E++ E + +EN
Sbjct: 1456 ----------LSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRREN 1505
Query: 750 QSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK 809
++L E++ L EQ+ + + + + E + Q ++EK + ++ +
Sbjct: 1506 KNLQQEISDLTEQIAEG---GKQIHELEKIKKQ-----------VEQEKCEIQAALEEAE 1551
Query: 810 QDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQ 869
+ E +++ E +Q K ++ EK EI L+ H + + +Q L ++
Sbjct: 1552 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSR 1611
Query: 870 ELLDKDALRLREANE-EIEKLKLEI---EKLKAESGNPSIRQKIRLKDKAADAKKIQDLE 925
DALR+++ E ++ ++++++ +L AES + LK+ +
Sbjct: 1612 ----NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667
Query: 926 RQVKEMEGILKRRYPNSLPALILAASAAGDTVDK-------------------------- 959
+KE I++RR N L A I A + ++
Sbjct: 1668 EDLKEQLAIVERR-ANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 960 -NTVEFMEKRIKKLEADLE-------GKDEDAKKSLRTMEQQFQKMKIQYE--------- 1002
NT + +E + +L++++E +E AKK++ +++K + +
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786
Query: 1003 QRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVK 1062
+ LEQ + L +L++ + +K +K++ + + VR LE E++ + +NAE VK
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL----EARVRELEGEVENEQKRNAEA-VK 1841
Query: 1063 KNDKDDEDFQSIEFQVEQAHAKA-KLVRLNEELAAKKREIQDLSKTVE-----RLQKDRR 1116
K + + + +Q E+ +L L ++L AK + + ++ E L K R+
Sbjct: 1842 GLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK 1901
Query: 1117 MMLSNQNSKGREEMSAKRAKK 1137
+ + ++ R +++ + K
Sbjct: 1902 LQHELEEAEERADIAESQVNK 1922
Score = 75.5 bits (184), Expect = 3e-13
Identities = 93/439 (21%), Positives = 186/439 (42%), Gaps = 89/439 (20%)
Query: 979 KDEDAKKSLRTMEQQFQKMKIQYEQ----RLEQQEQLLACKLNQHDSP-RIKALEKELDD 1033
K + +K + TM+++FQK K + + R E +E+++ ++D ++++ L D
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 1034 IKEAHQITVRN---LEAEIDVLKHQ-------NAELDVKKNDKDDE------DFQSIEFQ 1077
+E + ++N LEA+I + + NAEL KK +DE D +E
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 1078 V----EQAHA-KAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSA 1132
+ ++ HA + K+ L EE+A I LSK + LQ+ + L +++ A
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL--------DDLQA 1015
Query: 1133 KRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNE 1192
+ K ++L +K +KL Q ++LEG + ++ +
Sbjct: 1016 EEDKVNILTKAK-----------TKLEQQ------------------VDDLEGSLEQEKK 1046
Query: 1193 LKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRK 1252
L+M E + E ++ +E T E +K +E +++ L K
Sbjct: 1047 LRMDLERAKRKLEGDLKLAQESTM----------DMENDKQQLDEKLEKKEFEISNLISK 1096
Query: 1253 IATQEVLIRHFQSQVNELQSKQESL-------VVSEVREEILQKEITKLLEELREAKENH 1305
I ++ + Q ++ ELQ++ E L S + E + ++++ LEE+ E E
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156
Query: 1306 TPEMKHFVGLEKKIKQMEMRHAQREQE--------LQQIIQQTHQVVETEQNKEVEKWKR 1357
V L KK ++ E + +R+ E + +++ H E ++++ +R
Sbjct: 1157 GGATSAQVELNKK-REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQR 1215
Query: 1358 LAQLKNRELEKFRTELDSI 1376
+ Q +E + + E D +
Sbjct: 1216 VKQKLEKEKSELKMETDDL 1234
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 110 bits (274), Expect = 1e-23
Identities = 190/880 (21%), Positives = 385/880 (43%), Gaps = 132/880 (15%)
Query: 553 KKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKK 612
K+++ KL + + +D K + +KK + S I+ + +LG + K K+
Sbjct: 1056 KRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE-QALGMQLQKKIKE 1114
Query: 613 LLMFKRVQEAEDKW---RGAQALIEQIKATFSEKEKELENKLEE----------LKKQQE 659
L R++E E++ R ++A E+ ++ S + +E+ +LEE + K++E
Sbjct: 1115 LQA--RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1172
Query: 660 KELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQG 719
E K+ +D L+ E T R H A+ GE++ +Q+ Q+ E
Sbjct: 1173 AEFQKMRRD---LEEATLQHEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLEKEKSE 1227
Query: 720 YQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPT 779
+ E + L + ++ + + K N E+M + + SE+ + +E+ + ++ D
Sbjct: 1228 MKMEIDDLASNMETVSKA-KGNLEKMCRALEDQLSEIKTKEEEQQR------LINDLTAQ 1280
Query: 780 RNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQ---AKDQIAYV 836
R + T+ E EKD+L + +L + KQA E++K++ ++ AK +A+
Sbjct: 1281 RARLQTES-GEYSRQLDEKDTL---VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 837 TGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKL 896
++ +L E +++E + AE Q + K AN E+ + + + E
Sbjct: 1337 LQSSRHDCDLLREQYEEE-------QEAKAELQRAMSK-------ANSEVAQWRTKYETD 1382
Query: 897 KAESGNPSIRQKIRLKDKAADAKK-IQDLERQVKEMEGILKRRYPNSLPALIL------A 949
+ K +L + DA++ ++ + + +E K+R N + L++ A
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT-KQRLQNEVEDLMIDVERTNA 1441
Query: 950 ASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQE 1009
A AA D +N + + + +K E + + E ++K R++ + K+K YE+ L+Q E
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKCE-ETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 1010 QLLACKLNQHDSPRIKALEKEL-DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDD 1068
L + N++ I L +++ + K H++ + E + + Q A L+ + +
Sbjct: 1501 TLK--RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ-AALEEAEASLEH 1557
Query: 1069 EDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGRE 1128
E+ + + Q+E K+++ R ++A K EI + + R+ + M S +++ R
Sbjct: 1558 EEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQMKRNHIRIVES---MQSTLDAEIRS 1611
Query: 1129 EMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLIS 1188
A R KK + +G+ N +Q N+ + E L +
Sbjct: 1612 RNDAIRLKKKM----EGDLNEME---------------------IQLNHANRMAAEALRN 1646
Query: 1189 EKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASH---QREIEKLLCQNAVENSSSK 1245
+N + + ++ + R +ED +A ++ Q EIE+L S K
Sbjct: 1647 YRNTQAILKDTQLHL--DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704
Query: 1246 VAELNRKIATQEVLIRHFQS------------QVNELQSKQESLVVSEVR--EEILQKEI 1291
+AE A++ V + H Q+ ++++Q + E ++ E R EE +K I
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED-IIQEARNAEEKAKKAI 1763
Query: 1292 TK---LLEELREAKEN--HTPEMKHFVGLEKKIKQMEMRHAQREQ-----------ELQQ 1335
T + EEL++ ++ H MK LE+ +K ++ R + EQ +L+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA 1821
Query: 1336 IIQQTHQVVETEQNKEVEKWKRLAQLKNRELE-KFRTELD 1374
+++ VE+EQ + VE K L + + + E ++TE D
Sbjct: 1822 RVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEED 1861
Score = 80.9 bits (198), Expect = 8e-15
Identities = 208/1102 (18%), Positives = 445/1102 (40%), Gaps = 190/1102 (17%)
Query: 123 DTLEEQEEKEQFFARLE-KGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHE 181
+ E E++E+ A L K + S L K++D + T A++ ++H
Sbjct: 925 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL----------AKVEKEKHA 974
Query: 182 NESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGML--AN 239
E+K + L E + DE + A LT +E + + + + + + EE+K L A
Sbjct: 975 TENKVKNLTEEMAG--LDETI-AKLT---KEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 240 VVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALH------ 293
+ L +D + E +L+++ KI E ++ S +D + L
Sbjct: 1029 IKLEQQVDDL-EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 294 -------QAYCHIAHSLGDEDKQKIES--NTVEDIKSSVKGHPQENEENSKNISTMESDL 344
Q+ +LG + ++KI+ +E+++ ++ + K S + +L
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 345 PTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNL 404
+ E ++ ++ G + ++ + +++E EF KM ++ QH
Sbjct: 1148 EEISERLE----EAGGATSAQIE------MNKKREAEF-----QKMRRDLEEATLQHEAT 1192
Query: 405 FFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDK 464
++ E ++N +V + E+ KM ++ L + S + +K
Sbjct: 1193 AATLRKKHADSVAELGEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 465 INKTYRSQLSS----EEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYAS--------VRS 512
+ + QLS EEE + + ++AR + +SG Y+ V
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARL-------QTESGEYSRQLDEKDTLVSQ 1304
Query: 513 SGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPA 572
GK + ++ K+ E+ IK+K+ +++ + Q + + L++ ++
Sbjct: 1305 LSRGKQAFTQQIEEL--KRQLEEEIKAKS--ALAHALQSSRHDC----DLLREQYEEEQE 1356
Query: 573 HKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQAL 632
K E L N +++TD++ E +E K + +R+Q+AE+ A
Sbjct: 1357 AKAE--LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 633 IEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFG 692
++ T ++ L+N++E+L E+ N L K +F++
Sbjct: 1415 CASLEKT----KQRLQNEVEDLMIDVERT----NAACAALDKKQRNFDKI---------- 1456
Query: 693 EAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQ---VKDLQEQNKKNEERMFKEN 749
L + +++ +E L+ Q+E+ L + +K+ E++ E + +EN
Sbjct: 1457 ----------LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 750 QSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLK 809
++L E++ L EQ+ + +E + Q ++L A L A+ + I R++
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
Query: 810 QDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETH---------KQEISRLQK 860
+ ++ + ++ E+D+ DQ+ K I+I+E + + RL+K
Sbjct: 1567 LELNQVKSEVDRKIAEKDEEIDQM------KRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1620
Query: 861 RLQW----------------------YAENQELLD------KDALRLREANEE----IEK 888
+++ Y Q +L DALR +E +E +E+
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVER 1680
Query: 889 ----LKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKR------R 938
L+ EIE+L+A +KI ++ ++++Q L Q + K+ +
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740
Query: 939 YPNSLPALILAASAAGDTVDKNTVE--FMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQK 996
+ +I A A + K + M + +K K++D L M++ ++
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELK--------KEQDTSAHLERMKKNLEQ 1792
Query: 997 MKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQN 1056
+ RL++ EQ LA K + +++A +EL+ E+ Q RN+EA + KH+
Sbjct: 1793 TVKDLQHRLDEAEQ-LALKGGKKQIQKLEARVRELEGEVESEQ--KRNVEAVKGLRKHER 1849
Query: 1057 AELDVK-KNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR 1115
++ + ++D ++ ++ V++ AK K + E A ++ + L K R
Sbjct: 1850 KVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNV--------NLSKFR 1901
Query: 1116 RMMLSNQNSKGREEMSAKRAKK 1137
R+ + ++ R +++ + K
Sbjct: 1902 RIQHELEEAEERADIAESQVNK 1923
Score = 72.8 bits (177), Expect = 2e-12
Identities = 93/431 (21%), Positives = 191/431 (44%), Gaps = 73/431 (16%)
Query: 979 KDEDAKKSLRTMEQQFQKMKIQYEQ----RLEQQEQLLACKLNQHDSP-RIKALEKELDD 1033
K + +K + M+++F+K K + + R E +E+++ ++D +++A L D
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 1034 IKEAHQITVRN---LEAEIDVLKHQ-------NAELDVKKNDKDDE------DFQSIEFQ 1077
+E ++ LEA+I + + NAEL KK +DE D +E
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 1078 V----EQAHA-KAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSA 1132
+ ++ HA + K+ L EE+A L +T+ +L K+++ L + + +++ A
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAG-------LDETIAKLTKEKK-ALQEAHQQTLDDLQA 1016
Query: 1133 KRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNE 1192
+ K + L +K L+ L Q ++ + R K +LEG +
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQE--------KKIRMDLERAKRKLEG------D 1062
Query: 1193 LKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRK 1252
LK+ E+ M+ EN +++ E LK ++E E Q+ +E+ + +L +K
Sbjct: 1063 LKLAQESTMD-IENDKQQLDE-------KLK---KKEFEMSGLQSKIEDEQALGMQLQKK 1111
Query: 1253 IATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHF 1312
I+ Q+++ EL+ + E+ S + E + ++++ LEE+ E E
Sbjct: 1112 -------IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164
Query: 1313 VGLEKK--IKQMEMRHAQREQELQQ-----IIQQTHQVVETEQNKEVEKWKRLAQLKNRE 1365
+ + KK + +MR E LQ +++ H E ++++ +R+ Q +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 1366 LEKFRTELDSI 1376
+ + E+D +
Sbjct: 1225 KSEMKMEIDDL 1235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,343,819
Number of Sequences: 37866
Number of extensions: 2281513
Number of successful extensions: 27772
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 1407
Number of HSP's that attempted gapping in prelim test: 12103
Number of HSP's gapped (non-prelim): 8624
length of query: 1403
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1288
effective length of database: 13,892,928
effective search space: 17894091264
effective search space used: 17894091264
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.