Search of human proteins with 148612795

Search of human proteins with 148612795

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
         (1051 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...  2148   0.0  
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...  2035   0.0  
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...  1191   0.0  
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...  1184   0.0  
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...  1130   0.0  
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...  1123   0.0  
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]   129   2e-29
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]   129   2e-29
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]   129   2e-29
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]              115   2e-25
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              114   5e-25
gi|54607014 TBC1 domain family, member 25 [Homo sapiens]              110   5e-24
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    60   1e-08
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]    56   2e-07
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]    56   2e-07
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]    56   2e-07
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               51   7e-06
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              49   2e-05
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]              46   2e-04
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    44   0.001
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    44   0.001
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              40   0.009
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               39   0.020
gi|116292170 RUN domain containing 2A [Homo sapiens]                   39   0.026
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]     39   0.034
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]               38   0.057
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]             38   0.057
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    38   0.057
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    38   0.057
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    38   0.057

>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1051

 Score = 2148 bits (5566), Expect = 0.0
 Identities = 1051/1051 (100%), Positives = 1051/1051 (100%)

Query: 1    MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
            MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA
Sbjct: 1    MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60

Query: 61   GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
            GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP
Sbjct: 61   GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120

Query: 121  ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
            ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA
Sbjct: 121  ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180

Query: 181  LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
            LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA
Sbjct: 181  LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240

Query: 241  ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
            ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN
Sbjct: 241  ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300

Query: 301  GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
            GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL
Sbjct: 301  GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360

Query: 361  LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
            LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI
Sbjct: 361  LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480
            IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI
Sbjct: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480

Query: 481  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540
            EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI
Sbjct: 481  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540

Query: 541  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600
            VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE
Sbjct: 541  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600

Query: 601  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 660
            LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV
Sbjct: 601  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 660

Query: 661  VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 720
            VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR
Sbjct: 661  VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 720

Query: 721  PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 780
            PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED
Sbjct: 721  PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 780

Query: 781  GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 840
            GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH
Sbjct: 781  GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 840

Query: 841  RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900
            RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL
Sbjct: 841  RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900

Query: 901  AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 960
            AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF
Sbjct: 901  AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 960

Query: 961  LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 1020
            LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF
Sbjct: 961  LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 1020

Query: 1021 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
            FNERAEHHDAQEILRIARDLVHKVQMLIENK
Sbjct: 1021 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1051


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1006

 Score = 2035 bits (5272), Expect = 0.0
 Identities = 1005/1051 (95%), Positives = 1006/1051 (95%), Gaps = 45/1051 (4%)

Query: 1    MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60
            MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA
Sbjct: 1    MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA 60

Query: 61   GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120
            GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP
Sbjct: 61   GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP 120

Query: 121  ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180
            ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA
Sbjct: 121  ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA 180

Query: 181  LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240
            LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA
Sbjct: 181  LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA 240

Query: 241  ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300
            ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN
Sbjct: 241  ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN 300

Query: 301  GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360
            GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL
Sbjct: 301  GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL 360

Query: 361  LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420
            LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI
Sbjct: 361  LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI 420

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480
            IYPGHRHEH                                             +AGDMI
Sbjct: 421  IYPGHRHEH---------------------------------------------NAGDMI 435

Query: 481  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540
            EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI
Sbjct: 436  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 495

Query: 541  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600
            VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE
Sbjct: 496  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 555

Query: 601  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 660
            LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV
Sbjct: 556  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 615

Query: 661  VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 720
            VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR
Sbjct: 616  VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSR 675

Query: 721  PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 780
            PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED
Sbjct: 676  PKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEED 735

Query: 781  GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 840
            GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH
Sbjct: 736  GGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLH 795

Query: 841  RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900
            RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL
Sbjct: 796  RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855

Query: 901  AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 960
            AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF
Sbjct: 856  AYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 915

Query: 961  LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 1020
            LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF
Sbjct: 916  LLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKF 975

Query: 1021 FNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
            FNERAEHHDAQEILRIARDLVHKVQMLIENK
Sbjct: 976  FNERAEHHDAQEILRIARDLVHKVQMLIENK 1006


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score = 1191 bits (3081), Expect = 0.0
 Identities = 638/1153 (55%), Positives = 780/1153 (67%), Gaps = 115/1153 (9%)

Query: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65

Query: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122

Query: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182

Query: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241

Query: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301

Query: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361

Query: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMI---------CSRNLTAPN 471
            IYPG + E +  ++  L ++ + SV           +ML +              L  P+
Sbjct: 422  IYPGMQSEFVAPDF--LGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPS 479

Query: 472  PMKDAGDMIEMQGFGPS-LPA-WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPL 529
            P +      ++     S LP+ W   P   + SSC SCS S S   + ++  C  +R PL
Sbjct: 480  PKEQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPL 535

Query: 530  RLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWS 589
            +LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W 
Sbjct: 536  KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 595

Query: 590  KYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQ 649
            +Y  D  +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD  + A Y 
Sbjct: 596  QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 655

Query: 650  QVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTI------------ 697
            Q +AEW  CE +VRQRERE+H A   K SSG+S+DSH+ R++HRDSTI            
Sbjct: 656  QTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGR 715

Query: 698  -----------SNDVFISVDDLEPPEPQDP-EDSRPK----------------------- 722
                       S  VF SVD++E  E +   E+ +PK                       
Sbjct: 716  QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNF 775

Query: 723  -----PEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQS----------- 766
                    E    T  + +  Q+++     P  G    R  S A+  Q            
Sbjct: 776  SSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQD 835

Query: 767  ----------SLDEGQSV------GFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQA 810
                      S+DE  S+         E+D    EG        H   + +D   E+P+ 
Sbjct: 836  SLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEM 895

Query: 811  GELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNYWYFTP 858
              L       AV  +A            Y+ ELLD   +NLHRI+KDVQRCDRNYWYFTP
Sbjct: 896  ESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTP 955

Query: 859  PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPN 918
             NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+QNFP+
Sbjct: 956  ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPH 1015

Query: 919  GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWE 978
            GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DVF VWE
Sbjct: 1016 GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWE 1075

Query: 979  VIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIAR 1038
             IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++L++AR
Sbjct: 1076 TIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLAR 1135

Query: 1039 DLVHKVQMLIENK 1051
            DLV+KVQ LIENK
Sbjct: 1136 DLVYKVQTLIENK 1148


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score = 1184 bits (3064), Expect = 0.0
 Identities = 631/1142 (55%), Positives = 764/1142 (66%), Gaps = 148/1142 (12%)

Query: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65

Query: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122

Query: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182

Query: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241

Query: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301

Query: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361

Query: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480
            IYPG + E +  +   ++ S   S                      L  P+P K      
Sbjct: 422  IYPGMQSEFVPQDLMDVSVSNLPS----------------------LWQPSPRK------ 453

Query: 481  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540
                                 SSC SCS S S   + ++  C  +R PL+LLC++MK QI
Sbjct: 454  ---------------------SSCSSCSQSGSADGSSTN-GCNHERAPLKLLCDNMKYQI 491

Query: 541  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600
            +SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W +Y  D  +Y+E
Sbjct: 492  LSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEE 551

Query: 601  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEV 660
             ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD  + A Y Q +AEW  CE 
Sbjct: 552  QELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEA 611

Query: 661  VVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTI----------------------- 697
            +VRQRERE+H A   K SSG+S+DSH+ R++HRDSTI                       
Sbjct: 612  IVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSS 671

Query: 698  SNDVFISVDDLEPPEPQDP-EDSRPK----------------------------PEQEAG 728
            S  VF SVD++E  E +   E+ +PK                               E  
Sbjct: 672  STQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPS 731

Query: 729  PGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQS---------------------S 767
              T  + +  Q+++     P  G    R  S A+  Q                      S
Sbjct: 732  LSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANES 791

Query: 768  LDEGQSV------GFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAA 821
            +DE  S+         E+D    EG        H   + +D   E+P+   L       A
Sbjct: 792  MDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLA 851

Query: 822  VCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMC 869
            V  +A            Y+ ELLD   +NLHRI+KDVQRCDRNYWYFTP NLE+LR++MC
Sbjct: 852  VTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMC 911

Query: 870  SYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANM 929
            SY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+QNFP+GGAMDTHFANM
Sbjct: 912  SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANM 971

Query: 930  RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSE 989
            RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DVF VWE IWAA+H+SS 
Sbjct: 972  RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1031

Query: 990  HFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIE 1049
            H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++L++ARDLV+KVQ LIE
Sbjct: 1032 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIE 1091

Query: 1050 NK 1051
            NK
Sbjct: 1092 NK 1093


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score = 1130 bits (2922), Expect = 0.0
 Identities = 608/1106 (54%), Positives = 752/1106 (67%), Gaps = 82/1106 (7%)

Query: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65

Query: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122

Query: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182

Query: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGS-MDDRPSLSA 241

Query: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301

Query: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361

Query: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVD--MEEMGTGRATDYVFRI 420
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMI---------CSRNLTAPN 471
            IYPG + E +  ++  L ++ + SV           +ML +              L  P+
Sbjct: 422  IYPGMQSEFVAPDF--LGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPS 479

Query: 472  PMKDAGDMIEMQGFGPS-LPA-WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPL 529
            P +      ++     S LP+ W   P   + SSC SCS S S   + ++  C  +R PL
Sbjct: 480  PKEQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPL 535

Query: 530  RLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWS 589
            +LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W 
Sbjct: 536  KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 595

Query: 590  KYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQ 649
            +Y  D  +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++     ++  Q
Sbjct: 596  QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQ 655

Query: 650  QV---------------LAEWKACEVVVRQRERE-----------------AHPATRTKF 677
             +               + E +  E   R  E++                  HP++   F
Sbjct: 656  NIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSH-NF 714

Query: 678  SSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVV 737
            SSG S         H + ++S +  +       P    P D      Q +   T      
Sbjct: 715  SSGLS--------EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAP 766

Query: 738  EQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTL 797
             ++ +V+ DS +S L ++ +      I  SLD    +   E+D    EG        H  
Sbjct: 767  REELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQ 821

Query: 798  REPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKD 845
             + +D   E+P+   L       AV  +A            Y+ ELLD   +NLHRI+KD
Sbjct: 822  ADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKD 881

Query: 846  VQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCF 905
            VQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF
Sbjct: 882  VQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCF 941

Query: 906  SHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK 965
            + LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK
Sbjct: 942  TELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK 1001

Query: 966  RELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERA 1025
            REL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE A
Sbjct: 1002 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMA 1061

Query: 1026 EHHDAQEILRIARDLVHKVQMLIENK 1051
            E H+ +++L++ARDLV+KVQ LIENK
Sbjct: 1062 ERHNTKQVLKLARDLVYKVQTLIENK 1087


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 1032

 Score = 1123 bits (2905), Expect = 0.0
 Identities = 601/1095 (54%), Positives = 736/1095 (67%), Gaps = 115/1095 (10%)

Query: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65

Query: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122

Query: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182

Query: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGS-MDDRPSLSA 241

Query: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301

Query: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361

Query: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVD--MEEMGTGRATDYVFRI 420
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421

Query: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMI 480
            IYPG + E +  +   ++ S   S                      L  P+P K      
Sbjct: 422  IYPGMQSEFVPQDLMDVSVSNLPS----------------------LWQPSPRK------ 453

Query: 481  EMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQI 540
                                 SSC SCS S S   + ++  C  +R PL+LLC++MK QI
Sbjct: 454  ---------------------SSCSSCSQSGSADGSSTN-GCNHERAPLKLLCDNMKYQI 491

Query: 541  VSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKE 600
            +SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W +Y  D  +Y+E
Sbjct: 492  LSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEE 551

Query: 601  LELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV--------- 651
             ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++     ++  Q +         
Sbjct: 552  QELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSS 611

Query: 652  ------LAEWKACEVVVRQRERE-----------------AHPATRTKFSSGSSIDSHVQ 688
                  + E +  E   R  E++                  HP++   FSSG S      
Sbjct: 612  TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSH-NFSSGLS------ 664

Query: 689  RLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSP 748
               H + ++S +  +       P    P D      Q +   T       ++ +V+ DS 
Sbjct: 665  --EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQ-DSL 721

Query: 749  DSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 808
            +S L ++ +      I  SLD    +   E+D    EG        H   + +D   E+P
Sbjct: 722  ESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEP 777

Query: 809  QAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQRCDRNYWYF 856
            +   L       AV  +A            Y+ ELLD   +NLHRI+KDVQRCDRNYWYF
Sbjct: 778  EMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYF 837

Query: 857  TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNF 916
            TP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ LMKRM+QNF
Sbjct: 838  TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNF 897

Query: 917  PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAV 976
            P+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKREL+Y+DVF V
Sbjct: 898  PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLV 957

Query: 977  WEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRI 1036
            WE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE H+ +++L++
Sbjct: 958  WETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKL 1017

Query: 1037 ARDLVHKVQMLIENK 1051
            ARDLV+KVQ LIENK
Sbjct: 1018 ARDLVYKVQTLIENK 1032


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score =  129 bits (323), Expect = 2e-29
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 842  IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
            I+KDV R DR   ++     P L  L D++ +Y     D+GYVQGM DLL+PLL  ++N+
Sbjct: 402  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461

Query: 899  QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957
              A+ CF+  M +M QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 462  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520

Query: 958  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017
            RW L+ FKRE  + D+  +WEV+W    +   +F L +  A++E+ ++ I + +  F +I
Sbjct: 521  RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 578

Query: 1018 IKFFNERAEHHDAQEIL 1034
            +K  NE +   D ++IL
Sbjct: 579  LKHINELSMKIDVEDIL 595



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)

Query: 588 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 646
           W+K    +     ++ ++Q ++ GG+ H +RK  W FLLG++ +  +K+E  Q+      
Sbjct: 313 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 372

Query: 647 RYQQVLAEWKA 657
            Y ++  +WK+
Sbjct: 373 EYFRMKLQWKS 383


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score =  129 bits (323), Expect = 2e-29
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 842  IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
            I+KDV R DR   ++     P L  L D++ +Y     D+GYVQGM DLL+PLL  ++N+
Sbjct: 416  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 475

Query: 899  QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957
              A+ CF+  M +M QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 476  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 534

Query: 958  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017
            RW L+ FKRE  + D+  +WEV+W    +   +F L +  A++E+ ++ I + +  F +I
Sbjct: 535  RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 592

Query: 1018 IKFFNERAEHHDAQEIL 1034
            +K  NE +   D ++IL
Sbjct: 593  LKHINELSMKIDVEDIL 609



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)

Query: 588 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 646
           W+K    +     ++ ++Q ++ GG+ H +RK  W FLLG++ +  +K+E  Q+      
Sbjct: 327 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 386

Query: 647 RYQQVLAEWKA 657
            Y ++  +WK+
Sbjct: 387 EYFRMKLQWKS 397


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score =  129 bits (323), Expect = 2e-29
 Identities = 69/197 (35%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 842  IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
            I+KDV R DR   ++     P L  L D++ +Y     D+GYVQGM DLL+PLL  ++N+
Sbjct: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492

Query: 899  QLAYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957
              A+ CF+  M +M QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551

Query: 958  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017
            RW L+ FKRE  + D+  +WEV+W    +   +F L +  A++E+ ++ I + +  F +I
Sbjct: 552  RWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 609

Query: 1018 IKFFNERAEHHDAQEIL 1034
            +K  NE +   D ++IL
Sbjct: 610  LKHINELSMKIDVEDIL 626



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 19/71 (26%), Positives = 39/71 (54%), Gaps = 1/71 (1%)

Query: 588 WSKYQKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAA 646
           W+K    +     ++ ++Q ++ GG+ H +RK  W FLLG++ +  +K+E  Q+      
Sbjct: 344 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 403

Query: 647 RYQQVLAEWKA 657
            Y ++  +WK+
Sbjct: 404 EYFRMKLQWKS 414


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score =  115 bits (289), Expect = 2e-25
 Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%)

Query: 704  SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 752
            +  DL PP   +PE         +  P+P  E GP       V ++       P+  L  
Sbjct: 245  AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298

Query: 753  -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 808
             P  +N   + G+  SL        +G+   +G  EE        AH  ++  +  + K 
Sbjct: 299  VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352

Query: 809  QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 865
            Q   +   +E        Y              I++DV R DR N +Y  P  P L  L 
Sbjct: 353  QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401

Query: 866  DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 924
            D++ +Y   H D+GYVQGM DLL+P+L  + N+  A+ CF   M+ +  NF      M  
Sbjct: 402  DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461

Query: 925  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 984
                +  L+++LD  L + +  + D     FC+RW L+ FKRE  + DV  +WEV+W   
Sbjct: 462  QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519

Query: 985  HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040
             +   +  L +A A+++  R+ +  +     +I+K  NE       +++L  A  L
Sbjct: 520  -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%)

Query: 583 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 641
           +T++ W+++   +   +++ EL  +++ GG+   +R++ W FLLG+  +  + +E +   
Sbjct: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340

Query: 642 AVVAARYQQVLAEWKACEVVVRQREREAH 670
                 Y ++  +WK+      +R    H
Sbjct: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  114 bits (285), Expect = 5e-25
 Identities = 66/211 (31%), Positives = 113/211 (53%), Gaps = 7/211 (3%)

Query: 842  IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
            +DKDV R DRN  +F     PN+E +R ++ +Y   +  VGY QGM DL+AP+L  + ++
Sbjct: 488  VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547

Query: 899  QLAYSCFSHLMKR-MSQNFPNGGAMDTHFANMRSLIQILDSELFE-LMHQNGDYTHFYFC 956
               + CF  LM+  +  + P    M+     +R L+++     ++ L+    D     FC
Sbjct: 548  SDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFC 607

Query: 957  YRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTD 1016
            +RW LL FKRE    +   +WE  WA  H  +++F LFI +A+V  Y + + +  +    
Sbjct: 608  HRWLLLCFKREFPEAEALRIWEACWA--HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQ 665

Query: 1017 IIKFFNERAEHHDAQEILRIARDLVHKVQML 1047
            ++  F   A H + + +LR AR L+++ ++L
Sbjct: 666  MLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 17/53 (32%), Positives = 31/53 (58%)

Query: 599 KELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 651
           +E +L + +++GGI+  IR +VWPFLL +Y    + +E E +       Y ++
Sbjct: 413 EEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEI 465



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 9/48 (18%)

Query: 258 LLYGKNHVLVQPKEDMEAV----PGYLSLHQSAE-----SLTLKWTPN 296
           ++Y KN+V V P E ++ +    PGYL L+   +     +L L W PN
Sbjct: 37  IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84


>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score =  110 bits (276), Expect = 5e-24
 Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%)

Query: 844 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 899
           KDV R DR + Y+  P    +L  L D++ +Y   H  V Y QGM DL +P+L  +D++ 
Sbjct: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349

Query: 900 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 958
            A+ CF  +MKR++ NF P+G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408

Query: 959 WFLLDFKRELLYEDVFAVWEVIWAA 983
           W LL+ KRE  ++D   + EV W++
Sbjct: 409 WLLLELKREFAFDDALRMLEVTWSS 433



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 19/54 (35%), Positives = 32/54 (59%)

Query: 602 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 655
           EL  ++Y+GG+E  +RK VW +LL  Y  G++ +E        +  Y+Q+ +EW
Sbjct: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 16/50 (32%), Positives = 28/50 (56%)

Query: 991  FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040
            F+LF+ LA++  +R+ I  N +D+ ++   F+     H    +LR AR L
Sbjct: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666


>gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens]
          Length = 830

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 49/199 (24%), Positives = 88/199 (44%), Gaps = 12/199 (6%)

Query: 833  DTVALNLHRIDKDVQRCDR-NYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPL 891
            DT      +I+ D+ RC + +    +P    + R V+ ++V  H D+ Y QG+  L AP 
Sbjct: 433  DTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPF 492

Query: 892  L-VTLDNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQN 947
            L +  +N+ LAY+C S  + +   NF    N   +  +      +I   D EL   +++ 
Sbjct: 493  LYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEI 552

Query: 948  GDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREII 1007
            G     Y    WFL  F        +F +W+ +     + +  F   I +A+++  R+ +
Sbjct: 553  GFIPDLY-AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRL 607

Query: 1008 RDNNMDFTDIIKFFNERAE 1026
              N   F + I  F++  E
Sbjct: 608  LANG--FNECILLFSDLPE 624


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)

Query: 838  NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 895
            +L  I  D+ R   N   F    P  + L  ++ +Y     DVGYVQGM  + A L++ L
Sbjct: 182  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 241

Query: 896  DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 952
            D    A+  FS+L+ +  Q      + G M T+FA      +    +LF    +N + T 
Sbjct: 242  DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 299

Query: 953  FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 1012
              +   W    + + L  +    +W+V         E F+   AL +++ + +I+    M
Sbjct: 300  DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 353

Query: 1013 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
            DF  + +F     E   A+E+       +  +QM   NK
Sbjct: 354  DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 388


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)

Query: 838  NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 895
            +L  I  D+ R   N   F    P  + L  ++ +Y     DVGYVQGM  + A L++ L
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 521

Query: 896  DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 952
            D    A+  FS+L+ +  Q      + G M T+FA      +    +LF    +N + T 
Sbjct: 522  DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 579

Query: 953  FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 1012
              +   W    + + L  +    +W+V         E F+   AL +++ + +I+    M
Sbjct: 580  DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 633

Query: 1013 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
            DF  + +F     E   A+E+       +  +QM   NK
Sbjct: 634  DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 668


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 17/219 (7%)

Query: 838  NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 895
            +L  I  D+ R   N   F    P  + L  ++ +Y     DVGYVQGM  + A L++ L
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 521

Query: 896  DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 952
            D    A+  FS+L+ +  Q      + G M T+FA      +    +LF    +N + T 
Sbjct: 522  DTAD-AFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKN-NLTP 579

Query: 953  FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 1012
              +   W    + + L  +    +W+V         E F+   AL +++ + +I+    M
Sbjct: 580  DIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TKM 633

Query: 1013 DFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1051
            DF  + +F     E   A+E+       +  +QM   NK
Sbjct: 634  DFIHMAQFLTRLPEDLPAEELFA----SIATIQMQSRNK 668


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 5/143 (3%)

Query: 841 RIDKDVQRCDRNYWYFTPPNL---ERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDN 897
           +I+ D+ R   N  +FT P     ++LR V+ ++ W++  +GY QG+  L A  L+ L+ 
Sbjct: 669 QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728

Query: 898 DQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDY--THFYF 955
           ++ A+ C   +++ +         +     + R L  +L  +L  LM   G +       
Sbjct: 729 EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788

Query: 956 CYRWFLLDFKRELLYEDVFAVWE 978
            + WFL+ F   L+   +  VW+
Sbjct: 789 TFNWFLVVFADSLISNILLRVWD 811


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 44/178 (24%), Positives = 81/178 (45%), Gaps = 21/178 (11%)

Query: 878  VGYVQGMCDLLAPLLVTLDNDQLA----------YSCFSHLMKRMSQNF-----PNGGAM 922
            + YVQGM +++ PL  T   D  +          + CF++LM  +  NF      +   +
Sbjct: 225  IAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGI 284

Query: 923  DTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWA 982
                  + S ++  D EL+ L  Q  +    +F +RW  L   +E L  DV  +W+ ++A
Sbjct: 285  TYKMEKVYSTLKDKDVELY-LKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFA 343

Query: 983  ARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040
                +   F+L +  A++   RE + +   DFT  ++   +     D  +IL+ A++L
Sbjct: 344  --DDNRFDFLLLVCCAMLMLIREQLLEG--DFTVNMRLLQD-YPITDVCQILQKAKEL 396


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 47/201 (23%), Positives = 86/201 (42%), Gaps = 13/201 (6%)

Query: 838  NLHRIDKDVQRCDRNYWYFTP--PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTL 895
            +L  I  D+ R   + + F    P  + L  ++ +Y     DVGYVQGM  + A L++ L
Sbjct: 543  SLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL 602

Query: 896  DNDQLAYSCFSHLMKRMSQNF---PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 952
            +    A+  F++L+ +  Q      +   M  +FA      +   S+LF L  ++   T 
Sbjct: 603  EEAD-AFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLF-LHFKSYSLTP 660

Query: 953  FYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNM 1012
              +   W    + + L  +    VW+V         E F+    L ++  Y +I+    M
Sbjct: 661  DIYLIDWIFTLYSKSLPLDLACRVWDVFCR----DGEEFLFRTGLGILRLYEDILL--QM 714

Query: 1013 DFTDIIKFFNERAEHHDAQEI 1033
            DF  I +F  +  E   ++++
Sbjct: 715  DFIHIAQFLTKLPEDITSEKL 735


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 27/131 (20%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 850 DRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLM 909
           +++Y   T   +++LR+V+ ++ W + D+GY QG+  L+A  L+ L+ +   +   + + 
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780

Query: 910 KRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--FCYRWFLLDFKRE 967
             M +++     + +   + R    ++  +L  L      Y   Y    + WFL+ F   
Sbjct: 781 VFMPRDYYTKTLLGSQ-VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDS 839

Query: 968 LLYEDVFAVWE 978
           ++ + +F +W+
Sbjct: 840 VVSDILFKIWD 850


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 27/131 (20%), Positives = 64/131 (48%), Gaps = 3/131 (2%)

Query: 850 DRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLM 909
           +++Y   T   +++LR+V+ ++ W + D+GY QG+  L+A  L+ L+ +   +   + + 
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780

Query: 910 KRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--FCYRWFLLDFKRE 967
             M +++     + +   + R    ++  +L  L      Y   Y    + WFL+ F   
Sbjct: 781 VFMPRDYYTKTLLGSQ-VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDS 839

Query: 968 LLYEDVFAVWE 978
           ++ + +F +W+
Sbjct: 840 VVSDILFKIWD 850


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 42/219 (19%), Positives = 81/219 (36%), Gaps = 29/219 (13%)

Query: 841  RIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900
            +I  D+ R         P   E    ++  +   H   GYVQG+ DL+ P  V    + +
Sbjct: 279  QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338

Query: 901  ------------------------AYSCFSHLMKRMSQNFPNG-GAMDTHFANMRSLIQI 935
                                     Y C S L+  +  N+      +      +  L+  
Sbjct: 339  EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398

Query: 936  LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFI 995
            +D ++   + Q+ +  +  F +RW      RE+       +W+  + +      HF L++
Sbjct: 399  IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456

Query: 996  ALALVEAYREIIRDNNMDFTDIIKFF-NERAEHHDAQEI 1033
              A +  +R+ I +   DF +++ F  N    H D ++I
Sbjct: 457  CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDI 494


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 39.3 bits (90), Expect = 0.020
 Identities = 44/213 (20%), Positives = 91/213 (42%), Gaps = 13/213 (6%)

Query: 830  ELLDTVALNLHRIDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCD 886
            ELL  +    H I  D+ R    + YF+    P    L +++ +Y     +VGY QG+  
Sbjct: 954  ELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISF 1013

Query: 887  LLAPLLVTLDNDQLAYSCFSHLMKRM---SQNFPNGGAMDTHFANMRSLIQILDSELFEL 943
            +   LL+ +  +Q A+     LM  +    Q  P+  ++      +  L+     +L+  
Sbjct: 1014 VAGVLLLHMSEEQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNH 1072

Query: 944  MHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAY 1003
            + +N + +   +   WFL  F  +     V  V+++I+    +     +  +AL+L+ + 
Sbjct: 1073 LEEN-EISPSLYAAPWFLTLFASQFSLGFVARVFDIIF----LQGTEVIFKVALSLLSSQ 1127

Query: 1004 REIIRDNNMDFTDIIKFFNERAEHHDAQEILRI 1036
              +I +    F +I++F        +  E+ +I
Sbjct: 1128 ETLIMECE-SFENIVEFLKNTLPDMNTSEMEKI 1159


>gi|116292170 RUN domain containing 2A [Homo sapiens]
          Length = 375

 Score = 38.9 bits (89), Expect = 0.026
 Identities = 51/182 (28%), Positives = 79/182 (43%), Gaps = 23/182 (12%)

Query: 2   GSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDS-SHIIALCGAVEACLLHQLRRRAA 60
           GS  +  ++ LL  +   VKQ       RK +  DS S +  LC   EA L H L+R   
Sbjct: 3   GSQNNDKRQFLLERLLDAVKQCQIRFGGRKEIASDSDSRVTCLCAQFEAVLQHGLKRSRG 62

Query: 61  GFLRSD--KMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGK 118
             L +   K AA F    +T PV     + V+E+  + E ++       +LR   S  G+
Sbjct: 63  LALTAAAIKQAAGFASKTETEPV---FWYYVKEVLNKHELQR-----FYSLRHIASDVGR 114

Query: 119 APALSPQALKHVWVRTALIEKVLDKVV-QYLAENC--SKYYEKEALLADPVFGPILASLL 175
             A         W+R AL E  L++ +   LA+ C  S +YE  + + D     +L ++ 
Sbjct: 115 GRA---------WLRCALNEHSLERYLHMLLADRCRLSTFYEDWSFVMDEERSSMLPTMA 165

Query: 176 VG 177
            G
Sbjct: 166 AG 167


>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
          Length = 336

 Score = 38.5 bits (88), Expect = 0.034
 Identities = 36/154 (23%), Positives = 71/154 (46%), Gaps = 8/154 (5%)

Query: 857  TPPNLER-LRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 915
            T P L+R L +V+ +Y   +  VGY QGM  +   L++  +N++ ++     L+ R+  +
Sbjct: 129  TDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPD 188

Query: 916  F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDV 973
            +  P    + T    +  L++     +  LM + G         RWF+  F   L  E V
Sbjct: 189  YYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-VLWTLLVSRWFICLFVDILPVETV 247

Query: 974  FAVWEVIWAARHISSEHFVLFIALALVEAYREII 1007
              +W+ ++          +  +AL L++ ++E+I
Sbjct: 248  LRIWDCLFN----EGSKIIFRVALTLIKQHQELI 277


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score = 37.7 bits (86), Expect = 0.057
 Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 14/193 (7%)

Query: 838  NLHRIDKDVQRCDRNYWYFTPP---NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVT 894
            ++ +ID DV R  R++  F        + L  V+ +Y   + +VGY QGM  + A LL+ 
Sbjct: 140  DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMY 199

Query: 895  LDNDQLAYS---CFSHLMKRMSQNFPNGGAMDTHF-ANMRSLIQILDSELFELMHQNGDY 950
            ++ +   ++    FS     M   F  G      F  +   ++    S+L + +     Y
Sbjct: 200  MNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIY 259

Query: 951  THFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDN 1010
            T FY   +WF   F    L    F +   IW       E  +  ++  +++ +++ +   
Sbjct: 260  TSFY-TMKWFFQCF----LDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL 314

Query: 1011 NMDFTDIIKFFNE 1023
            +M+  ++++FF E
Sbjct: 315  SME--ELVEFFQE 325


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score = 37.7 bits (86), Expect = 0.057
 Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 14/193 (7%)

Query: 838  NLHRIDKDVQRCDRNYWYFTPP---NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVT 894
            ++ +ID DV R  R++  F        + L  V+ +Y   + +VGY QGM  + A LL+ 
Sbjct: 157  DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMY 216

Query: 895  LDNDQLAYS---CFSHLMKRMSQNFPNGGAMDTHF-ANMRSLIQILDSELFELMHQNGDY 950
            ++ +   ++    FS     M   F  G      F  +   ++    S+L + +     Y
Sbjct: 217  MNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIY 276

Query: 951  THFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDN 1010
            T FY   +WF   F    L    F +   IW       E  +  ++  +++ +++ +   
Sbjct: 277  TSFY-TMKWFFQCF----LDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL 331

Query: 1011 NMDFTDIIKFFNE 1023
            +M+  ++++FF E
Sbjct: 332  SME--ELVEFFQE 342


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 37.7 bits (86), Expect = 0.057
 Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)

Query: 9   KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
           +  L+  +K  +K +++ A++  + +  D + +      +E CL H L+ + +   ++  
Sbjct: 5   RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 64

Query: 68  MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
                  V K CP A +I   V+ L +                   +A G+  A      
Sbjct: 65  FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 101

Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
              W+  AL++K L   ++ L +N    S++YE EAL+ +   G ++  LLVG
Sbjct: 102 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 150


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 37.7 bits (86), Expect = 0.057
 Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)

Query: 9   KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
           +  L+  +K  +K +++ A++  + +  D + +      +E CL H L+ + +   ++  
Sbjct: 5   RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 64

Query: 68  MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
                  V K CP A +I   V+ L +                   +A G+  A      
Sbjct: 65  FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 101

Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
              W+  AL++K L   ++ L +N    S++YE EAL+ +   G ++  LLVG
Sbjct: 102 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 150


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
           sapiens]
          Length = 708

 Score = 37.7 bits (86), Expect = 0.057
 Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 31/173 (17%)

Query: 9   KEKLLWNVKKEVKQIMEEAVTR-KFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDK 67
           +  L+  +K  +K +++ A++  + +  D + +      +E CL H L+ + +   ++  
Sbjct: 113 RANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKS 172

Query: 68  MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQAL 127
                  V K CP A +I   V+ L +                   +A G+  A      
Sbjct: 173 FFGPLELVEKLCPEASDIATSVRNLPELK-----------------TAVGRGRA------ 209

Query: 128 KHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVG 177
              W+  AL++K L   ++ L +N    S++YE EAL+ +   G ++  LLVG
Sbjct: 210 ---WLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIVGLLVG 258


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,636,298
Number of Sequences: 37866
Number of extensions: 2313075
Number of successful extensions: 10189
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 9812
Number of HSP's gapped (non-prelim): 462
length of query: 1051
length of database: 18,247,518
effective HSP length: 113
effective length of query: 938
effective length of database: 13,968,660
effective search space: 13102603080
effective search space used: 13102603080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.