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Search of human proteins with 148596998
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148596998 coiled-coil domain containing 122 [Homo sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148596998 coiled-coil domain containing 122 [Homo sapiens] 543 e-155
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 72 5e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 60 3e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 1e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 57 1e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 2e-08
gi|58530842 desmoplakin isoform II [Homo sapiens] 56 4e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 56 4e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 56 4e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 56 4e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 56 4e-08
gi|58530840 desmoplakin isoform I [Homo sapiens] 54 1e-07
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 54 1e-07
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 54 2e-07
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 54 2e-07
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 53 2e-07
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 53 3e-07
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 53 3e-07
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 53 3e-07
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens] 52 6e-07
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens] 52 6e-07
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens] 52 6e-07
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens] 52 6e-07
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 52 7e-07
gi|32698688 citron [Homo sapiens] 51 1e-06
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 51 1e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 51 1e-06
gi|221316642 nuclear distribution gene E homolog 1 [Homo sapiens] 50 2e-06
gi|8923110 nuclear distribution gene E homolog 1 [Homo sapiens] 50 2e-06
>gi|148596998 coiled-coil domain containing 122 [Homo sapiens]
Length = 273
Score = 543 bits (1398), Expect = e-155
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK 60
MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK
Sbjct: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK 60
Query: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE
Sbjct: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
Query: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNR 180
HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNR
Sbjct: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNR 180
Query: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQ 240
ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQ
Sbjct: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQ 240
Query: 241 VNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
VNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE
Sbjct: 241 VNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 72.0 bits (175), Expect = 5e-13
Identities = 70/275 (25%), Positives = 127/275 (46%), Gaps = 34/275 (12%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDS----- 81
+EK+ K+ S+ EIEK+KK + +++EL E +KE+ + E ++ E++I ++DS
Sbjct: 235 IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQK 294
Query: 82 ------AIENTKLHCDSLETQIKSLHS-------------ENVKLKFDIETAQEDFEEHM 122
A ENT LE KSL + E K +E A+++FEE M
Sbjct: 295 RPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM 354
Query: 123 IKYNAYYAK--------IKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQ 174
+ + + +K + E + + + + EK + +K + +L + +
Sbjct: 355 EEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKK 414
Query: 175 NPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAIL 234
+I Q +I + +I ++E I LEE+KK +L +E+E+ +R D I
Sbjct: 415 VETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEIN 474
Query: 235 KRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCI 269
K L+ + +L R Q + +Q K AE+ + I
Sbjct: 475 KELNQVMEQLGDARIDRQESSRQQRK--AEIMESI 507
Score = 39.7 bits (91), Expect = 0.003
Identities = 52/246 (21%), Positives = 100/246 (40%), Gaps = 25/246 (10%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
KE+ + + + S A ++ K QS + K + + NL+ E +LE E+A
Sbjct: 686 KEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT-KTRHLALNLQ-EKSKLESELAN 743
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQ-------------IKSLHSENVKLKFDI 111
+ +R I ++ +++ K + +E + I+ E VK + +I
Sbjct: 744 FGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEI 803
Query: 112 ETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQ 171
+ +FE + ++ KN L E + K +H VKK + E+L +
Sbjct: 804 AKKRLEFENQKTRLGI---QLDFEKNQLKEDQDK------VHMWEQTVKKDENEIEKLKK 854
Query: 172 DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYD 231
+ Q I + + +LK++ + K + +K +EE +K KE+ K
Sbjct: 855 EEQRHM-KIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVT 913
Query: 232 AILKRL 237
AI +L
Sbjct: 914 AIETKL 919
Score = 32.0 bits (71), Expect = 0.59
Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 18/122 (14%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQAS--EIEKNKKVLFNLKNELHEL 58
+ +N+ +K +E ++ ++LA +EK + Q++ ++E+ KKV E
Sbjct: 367 LEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKV---------ET 417
Query: 59 EKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDF 118
E +I E +E +++I + + I +K SLE Q K L E L ++E A+
Sbjct: 418 EAKIKQKLREIEENQKRIEKLEEYITTSK---QSLEEQ-KKLEGE---LTEEVEMAKRRI 470
Query: 119 EE 120
+E
Sbjct: 471 DE 472
Score = 28.9 bits (63), Expect = 5.0
Identities = 16/81 (19%), Positives = 41/81 (50%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
+EK+ K++Q I++ L +LKN+ + E+ + E +E +++ + + +
Sbjct: 849 IEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHL 908
Query: 87 KLHCDSLETQIKSLHSENVKL 107
+ ++ET+++ S+ L
Sbjct: 909 QKEVTAIETKLEQKRSDRHNL 929
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 59.7 bits (143), Expect = 3e-09
Identities = 62/265 (23%), Positives = 120/265 (45%), Gaps = 50/265 (18%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVL----FNLKNELHELEK 60
+E KS+ K N+ + + D E++ ++++ Q E+EK ++ L +L +++ EL+
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERL-RREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
+IA + + + E ++ + +E + +I+ L S+ I QED E
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ-------ISELQEDLES 1122
Query: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNR 180
N KA K +KRD ++L+ +K EL L +
Sbjct: 1123 ERASRN------KAEK-----------------QKRDLGEELEALKTELEDTLDS----- 1154
Query: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQ 240
T Q+++ + +++ + +I++KT LEEE KTHE +E+ +H + L Q
Sbjct: 1155 -TAAQQELRSKREQEV----NILKKT--LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 241 VNKLQSNRRQWQWNIQQLEKTAAEL 265
++++N + + Q LE EL
Sbjct: 1208 TKRVKANLEKAK---QTLENERGEL 1229
Score = 44.3 bits (103), Expect = 1e-04
Identities = 57/281 (20%), Positives = 119/281 (42%), Gaps = 19/281 (6%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASE-----IEKNKKVLFNLKNELHEL 58
+K + K+ ++ + +A + +Q+ SQA E +E+ K+V NL+ L
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 59 EKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDF 118
E E ++ E K + + DS + K+ E Q+K E V+ + + +
Sbjct: 1223 ENERGELANEVKVLLQG--KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 119 EEHMIKYNAYYAKIKAHK--NSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNP 176
E + + K+ K +ES+ EL ++ + K + K + ++D +N
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 177 GGNRITQVQEDITNLKDKIIT-------VKESIIEKTCFLEEEKKTHEKLRKEIEVQHKR 229
++ + +E NL+ +I T +K+ + + LE ++ KL+K++E +R
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400
Query: 230 YD---AILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRK 267
++ A +L +LQ ++ ++A L K
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Score = 42.7 bits (99), Expect = 3e-04
Identities = 56/258 (21%), Positives = 116/258 (44%), Gaps = 26/258 (10%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ ++ E+ K ++ +N L E+E + + AE + + Q+ +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 87 KLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE-VESK 145
+ L ++ + E ++ D+E E+ EE A K++ + L E +E +
Sbjct: 900 ----EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 146 WSFMTELH-EKRDFVKKLKTMKEE--LMQDLQNPGGNRITQVQEDITNLKDKIITVKESI 202
S +L EK KLK ++EE +++D QN ++ ++ L+D+I ++
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILED-QN------CKLAKEKKLLEDRIAEFTTNL 1008
Query: 203 IEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWN-------I 255
E+ EE+ K+ KL+ + E + L+R Q +L+ RR+ + + I
Sbjct: 1009 TEE----EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 256 QQLEKTAAELRKCIGMQE 273
+L+ AEL+ + +E
Sbjct: 1065 AELQAQIAELKMQLAKKE 1082
Score = 42.4 bits (98), Expect = 4e-04
Identities = 54/287 (18%), Positives = 125/287 (43%), Gaps = 30/287 (10%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+++ + +Q +E+N+ SL+ +++V ++ S ++E+ ++ NL+ ++ L ++
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 63 AAIS---------AETKETERQIYQQD-----SAIENTKLHCDSLETQIKSLHSENVKLK 108
A + ET E ++ Q+D E D LE L E L
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 109 FDIETAQE---DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTM 165
D++ ++ + E+ K++ A+ K E + E EK L
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE--AEAREKETKALSLARA 1484
Query: 166 KEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEV 225
EE M+ + ++ + + +++ K+ + + LE+ K+ E+ +E++
Sbjct: 1485 LEEAMEQKA-----ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 226 QHKRYDAILK-----RLHCQVNKLQSNRRQWQWNIQQLEKTAAELRK 267
Q + + L+ +L +VN LQ+ + Q++ ++Q ++ + E +K
Sbjct: 1540 QLEELEDELQATEDAKLRLEVN-LQAMKAQFERDLQGRDEQSEEKKK 1585
Score = 40.4 bits (93), Expect = 0.002
Identities = 47/259 (18%), Positives = 106/259 (40%), Gaps = 22/259 (8%)
Query: 17 NQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQI 76
N++ + K+ Q + E++ + + + E EK++ ++ AE + + ++
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 77 YQQDSAIENTKLHCDSLETQIKSLHS-------ENVKLKFDIETAQEDFEEHMIKYNAYY 129
+ A + D L +I + E +L+ I +E+ EE
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 130 AKIKAHKNSLGEVESKWSFMTELHEKRDFVKK-LKTMKEELMQDLQNPGGNRITQVQEDI 188
++K + ++ + + +K + ++ L+ +EL LQ G ++ + I
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 189 TNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNR 248
T L+ KI ++E L+ E K + K++ K+ LK + QV+ + N
Sbjct: 1810 TALEAKIAQLEEQ-------LDNETKERQAACKQVRRTEKK----LKDVLLQVDDERRNA 1858
Query: 249 RQWQWNIQQLEKTAAELRK 267
Q++ Q +K + L++
Sbjct: 1859 EQYK---DQADKASTRLKQ 1874
Score = 35.0 bits (79), Expect = 0.070
Identities = 48/256 (18%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 29 KVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKL 88
K+ K + S+++ +++L + L ++ + E Q+ +++ A N
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN--- 1354
Query: 89 HCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSF 148
LE QI +LH++ +K +E + E A K K K+ G
Sbjct: 1355 ----LEKQIATLHAQVADMKKKMEDSVGCLE------TAEEVKRKLQKDLEG-------- 1396
Query: 149 MTELHEKR----DFVKKLKTMKEELMQDL------QNPGGNRITQVQEDITNLKDKIITV 198
+++ HE++ D ++K KT ++ + DL Q + + Q+ L + T+
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 199 KESIIEKTCFLEEEKKTHE-------KLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQW 251
E+ E E + E + +E Q + + K+ ++ L S++
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 252 QWNIQQLEKTAAELRK 267
++ +LEK+ L +
Sbjct: 1517 GKSVHELEKSKRALEQ 1532
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/267 (20%), Positives = 119/267 (44%), Gaps = 24/267 (8%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELH----ELEKEIAAISAET 69
KE+ + + ++ KQ Q Q E E++ L + N+LH E E+++
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 70 KE----TERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKY 125
KE + ++ ++ + + +L LE Q+K + + +L+ ++ ++ +E
Sbjct: 438 KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ 497
Query: 126 NAYYAKIKAHKNSL-------GEVESKWSFMTELHEK-RDFVKKLKTMKEELMQDLQNPG 177
+ AK++ +N L G+ + K + L +K ++ + L+ +E+L +Q
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 178 GNR--ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILK 235
G + Q+QE L++++ + E + ++ E K+ E L +++ Q A
Sbjct: 558 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQS---ESHKQAQENLHDQVQEQKAHLRAAQD 614
Query: 236 R---LHCQVNKLQSNRRQWQWNIQQLE 259
R L VN+L S + + + QL+
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLD 641
Score = 55.1 bits (131), Expect = 7e-08
Identities = 66/293 (22%), Positives = 140/293 (47%), Gaps = 38/293 (12%)
Query: 16 DNQDTSSLADAVEKVAKQQQSQA---SEIEKNKKVLFNLKNELHELEKEIAAISAETKET 72
+N+ L A +++A +++ + + EK+++ L+++ + E E+ A + K
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 73 ERQIY--QQD-----SAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKY 125
E ++ Q+D + I N L+T +L ++ K + ++ + ++ +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 126 NAYYAKIKAHKNSLGEVES----KWSFMTELHE-----KRDFVKK---LKTMKEELMQ-- 171
+ ++ K+ L E+E + +T+L+E K + +K+ LK K+ L+Q
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 172 -DLQNPGGNRITQVQEDITN---LKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQH 227
+LQ + V+++ N LKD++ +E + K F+E+E K H ++ KE EV
Sbjct: 1173 LELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL--KKEFIEKEAKLHSEI-KEKEVGM 1229
Query: 228 KRYDAILKRLHCQVNKLQSN----RRQWQWN---IQQLEKTAAELRKCIGMQE 273
K+++ +L Q+ L N +++WQ + + +LEK +LR I + E
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Score = 50.1 bits (118), Expect = 2e-06
Identities = 49/258 (18%), Positives = 108/258 (41%), Gaps = 35/258 (13%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADA--------------VEKVAKQQQSQASEIEKNKK 46
+SD+ + F KE+ + +++ D +E K+Q+ +EK K+
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 47 VLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSE--- 103
LK EL+ +++++ K+ E++ Q I K + + QI++L E
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 104 --------NVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKW-----SFMT 150
KL+ + A ++ K + + + + +++S + +
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 151 ELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLE 210
+ + +KL +E+L+ + +N GN+ +QE LK T+++ +K L+
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQE----LKTAKATLEQDSAKKEQQLQ 1099
Query: 211 EEKKTHEKLRKEIEVQHK 228
E K + ++KE ++ K
Sbjct: 1100 ERCKALQDIQKEKSLKEK 1117
Score = 48.1 bits (113), Expect = 8e-06
Identities = 51/260 (19%), Positives = 115/260 (44%), Gaps = 28/260 (10%)
Query: 17 NQDTSSLADAVEKV--------AKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAE 68
N+ S L ++ EKV AK + ++E K + +L+N L + + E
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA-DLQNHLDTAQNALQDKQQE 682
Query: 69 TKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAY 128
+ Q+ Q + +++ + HC LE+ +K + + L E E+ E + K A
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL----EQKTEELEGQIKKLEAD 738
Query: 129 YAKIKAHK-NSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQED 187
++KA K +L +++ + T+L + + K M++E+ ++ + D
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI-----------VSSTRLD 787
Query: 188 ITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSN 247
+ + + ++K+ + ++ + K+ E L +E ++QH+ + R+ V +LQ
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN---NRIQTTVTELQKV 844
Query: 248 RRQWQWNIQQLEKTAAELRK 267
+ + + + +L +L K
Sbjct: 845 KMEKEALMTELSTVKDKLSK 864
Score = 43.5 bits (101), Expect = 2e-04
Identities = 46/248 (18%), Positives = 105/248 (42%), Gaps = 7/248 (2%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNL---KNELHELEKEIAAISAETKETERQIYQQDSAI 83
V+++ K + S +KN+ + NL + + +LE++ S K + ++Q+D
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 84 ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVE 143
+ + + ET + +H E + + +E+ E KY A+ K + E E
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 144 SK----WSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVK 199
S + +LH K ++ +++ + ++ ++ + +L+ K+ ++
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 200 ESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLE 259
E + EK E + +K +++ + Q + +L N L+ RQ Q+++
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 260 KTAAELRK 267
A L+K
Sbjct: 527 NLEALLQK 534
Score = 42.4 bits (98), Expect = 4e-04
Identities = 62/280 (22%), Positives = 121/280 (43%), Gaps = 26/280 (9%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAET---- 69
+E D + + ++ Q+ + ++K+K+ + L+ E +L +I A ET
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 70 --KETERQIYQQDSAI-ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYN 126
+E + +Q + + E K +S + ++LH + + K + AQ+ N
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 127 AYYAKIKAHKNSLGEVESKWSFMTEL---------HEKRDFVKKLKTMKEELMQDLQNPG 177
+++ K + +++ + TEL ++ D L T + L QD Q
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL-QDKQQEL 683
Query: 178 GNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH---EKLRKEIEVQHKRYDA-I 233
TQ+ + L+DK +E + L+E K+ + E+ +E+E Q K+ +A
Sbjct: 684 NKITTQLDQVTAKLQDK----QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 234 LKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
L+ + LQ ++Q Q N LE A EL K + M++
Sbjct: 740 LEVKASKEQALQDLQQQRQLN-TDLELRATELSKQLEMEK 778
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/274 (21%), Positives = 117/274 (42%), Gaps = 55/274 (20%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIEKNK----KVLFNLKNEL--HELE--KEIAAISAET 69
QD EK ++S+ +EIE+ K K + L EL H+LE KEI +
Sbjct: 1106 QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL---- 1161
Query: 70 KETERQIYQQD-----------SAIENTKLHCDSLETQIKSLHSE--------NVKLKFD 110
K+ ++ + QQ +A+E K + L+ Q+K E KL +
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221
Query: 111 IETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSF----MTELHEKRDFVKKLKTMK 166
I+ + ++H +I A +LG V+ +W ++EL ++ D ++ +
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
Query: 167 EELMQDLQNPGG---NRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLR--- 220
E +Q+ Q+ R + + +I L+ K++ ++ + T ++E + ++ L+
Sbjct: 1282 EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341
Query: 221 ---------KEIEVQH-----KRYDAILKRLHCQ 240
++ EVQ+ K + ++R HC+
Sbjct: 1342 TQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCR 1375
Score = 38.9 bits (89), Expect = 0.005
Identities = 46/236 (19%), Positives = 99/236 (41%), Gaps = 37/236 (15%)
Query: 32 KQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCD 91
K+++ + E++K + L+ + + + + SAE + E+Q+ + + N K D
Sbjct: 100 KEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKD 159
Query: 92 SLETQIKSLHSE--NVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFM 149
E + L +E ++K K+D E + + E +
Sbjct: 160 LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT----------------------RLT 197
Query: 150 TELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFL 209
EL+++ ++ LKT + LQ PG ED+ LK +++ V+ + T
Sbjct: 198 EELNKEATVIQDLKT------ELLQRPG-------IEDVAVLKKELVQVQTLMDNMTLER 244
Query: 210 EEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
E E + + K+++ Q+ +A + +L ++ K + +Q+L+ + EL
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Score = 37.7 bits (86), Expect = 0.011
Identities = 54/297 (18%), Positives = 119/297 (40%), Gaps = 34/297 (11%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
++ K++ + +D + L + +V + E E+ + LK+E +L+ + A+
Sbjct: 208 QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE---KLKDECKKLQSQYAS 264
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK 124
A + ++ + + L++ + L +N L ++ ++D+ + K
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324
Query: 125 YNAYYAKIK-----AHKNSLG--EVESKWS--------FMTELHEKRDFVKKLKTMKEEL 169
+N K H+ L +++S+ S EL EK + +KLK E+
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
Query: 170 -------------MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH 216
+Q + Q+Q +I L K++ + + E L+E+++
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 217 EKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
+ + E Q L RL Q+ + +N + Q QL+KT + ++ +Q+
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ---HQLDKTKQQHQEQQALQQ 498
Score = 28.1 bits (61), Expect = 8.6
Identities = 26/107 (24%), Positives = 53/107 (49%), Gaps = 20/107 (18%)
Query: 172 DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIE------V 225
D + G + + ++D+T L+ ++ ++ S L+EEK E+L+KE+E
Sbjct: 69 DSGHGGESNLALKRDDVTLLRQEVQDLQAS-------LKEEKWYSEELKKELEKYQGLQQ 121
Query: 226 QHKRYDAILKRLHCQVNKLQSNRRQWQ---WNIQQL----EKTAAEL 265
Q + D ++ ++ L+ + Q +NI+Q+ E+ AA+L
Sbjct: 122 QEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL 168
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 57.4 bits (137), Expect = 1e-08
Identities = 52/239 (21%), Positives = 108/239 (45%), Gaps = 6/239 (2%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+N +K Q E QD ++K ++ + + +E+ +K +L+ E +LEK+
Sbjct: 773 ENSNKKIQQLESE-LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 63 AAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEH- 121
+ E K +Q +D+ +E + +LE + K+L E K +E +E+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 122 -MIKYNAYYAK--IKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGG 178
++K K + ++ + E +L + ++K+ KE L+ D Q+
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 179 NRITQVQEDITNLKDKIITVKES-IIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKR 236
+R ++ + + K + +KE I LEE +++LR+E++ K Y+A+ +R
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Score = 55.1 bits (131), Expect = 7e-08
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 19/268 (7%)
Query: 1 MSDNKERKSQGFP--KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHEL 58
+ KE+ +G K + T L + + + + Q +E + K + L++EL +L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 59 EKEIAAISA---ETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQ 115
E E + E K + +++ Q + ++ + LE K L EN +L+ E
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 116 EDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELH-EKRDFVKK-------LKTMKE 167
EE+ +K + K +G + + EL E ++ VK+ L T++E
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 168 ELMQD-----LQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKE 222
+L+ + N ++T E I K++++ ++S + + + E K L+K
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS-TDDSRYKLLESKLESTLKKS 968
Query: 223 IEVQHKRYDAILKRLHCQVNKLQSNRRQ 250
+E++ ++ A+ RL N Q R++
Sbjct: 969 LEIKEEKIAALEARLEESTNYNQQLRQE 996
Score = 53.1 bits (126), Expect = 2e-07
Identities = 62/284 (21%), Positives = 124/284 (43%), Gaps = 29/284 (10%)
Query: 15 EDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKE------------- 61
E ++TSS +E +Q + + ++ + L+NELH LEKE
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 62 ----IAAISAETKETERQ---IYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETA 114
I A+ E E ER+ + + + +N +SLE + L EN++L+ ++E+
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 115 QEDFEEHMIKYNAYYAKIKAHKNSLGE-VESKWSFMTELHEKRDFVKKLKTMKEELMQDL 173
+ M + ++++ K L + +E + + + L + L + L
Sbjct: 714 -KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 174 QNPGGNRITQVQEDITNLKDKIITVKESIIE------KTCFLEEEKKTHEKLRKEIEVQH 227
+N +I Q++ ++ +L+ + T+++++ E + LE+E K+ E+ ++E
Sbjct: 773 EN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 228 KRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGM 271
K+ + KRL Q + + I LEK L K IG+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/318 (21%), Positives = 136/318 (42%), Gaps = 70/318 (22%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF----NLKNELH 56
+ +N ER+ + +E+ +++ ++ +++ +IEK K+L ++L
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 57 ELEKEIAAISAE----------TKETERQIYQQD-------SAIENTKLHC---DSLETQ 96
++E E I E +E E +++ + I N K+ C ++LE +
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 97 IKSLHSENVKLK---------------FDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE 141
L EN KLK + E +Q D E ++ N K + K + +
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 142 VESKWSFMTELHEKRDFVKK-LKTMKEELMQ-----------DLQNPGGNRITQVQEDIT 189
+E+K EL +++ +KK L+ +K + D++N ++Q+ +
Sbjct: 725 LENK-----ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN------QRLQKTLE 773
Query: 190 NLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRR 249
N KI ++ + + LE E +T +K +E+++ KR L++L + L+
Sbjct: 774 NSNKKIQQLESELQD----LEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETS 825
Query: 250 QWQWNIQQLEKTAAELRK 267
Q + + +QLEK LR+
Sbjct: 826 QLEKDKKQLEKENKRLRQ 843
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/293 (20%), Positives = 137/293 (46%), Gaps = 35/293 (11%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLK---NELHEL 58
S+ E + E N+ TSS + K+ + QS +E+ + + +++ +++ ++
Sbjct: 440 SELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 59 EKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDF 118
EKE +S + + E +I Q+ +++N C +L K L E +L+ IET +E+
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQN----CQNLS---KDLMKEKAQLEKTIETLRENS 549
Query: 119 E----------EHM---IKYNAYYAKIKAHKNSLGEVESKWSFMTE-LHEKRDFVKKLKT 164
E EH+ + ++I A + ++E + + E + E + K++
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKENKILHESIKETSSKLSKIEF 608
Query: 165 MKEELMQDLQN--PGGNRITQVQEDITNL--KDKIITVKESIIEKTC-FLEEEKKTHEKL 219
K ++ ++L++ G R +++ ++ +L +++++ K + ++ TC +E ++ + +L
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 220 RKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQ 272
+E K D+ K L Q+ L+ Q +L + L KC M+
Sbjct: 669 ERENRKLKKTLDS-FKNLTFQLESLEKENSQLDEENLELRRNVESL-KCASMK 719
Score = 44.3 bits (103), Expect = 1e-04
Identities = 63/290 (21%), Positives = 129/290 (44%), Gaps = 37/290 (12%)
Query: 3 DNK-ERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKE 61
DNK ER+SQ E ++ + D + +V + + +E + K L L+ + + L+ +
Sbjct: 1027 DNKWERESQ----ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 62 IAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEH 121
I A+ +T + Q + ++ +L +Q SL ++N +L +++ E+ E
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ-QSSLENENES 1141
Query: 122 MIKY-----NAYYAKIK-------AHKNSLGEVES---KWSFMTELH-----EKRDFVKK 161
+IK + Y + IK H+ E ES K + H E RD +
Sbjct: 1142 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 162 LKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEE-KKTHEK 218
+ ++ ++DL+ ++ +V+++ L++K + +K C + T+ +
Sbjct: 1202 YNQLLKQKGQLEDLE-----KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
Query: 219 LRKEIEV---QHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
L KE EV HK ++L + +L++ + + QQL+ T+ +L
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
Score = 38.9 bits (89), Expect = 0.005
Identities = 55/246 (22%), Positives = 104/246 (42%), Gaps = 33/246 (13%)
Query: 15 EDNQDTSSLADAV----EKVAKQQQSQASEIEKN-------KKVLFNLKNELHELE---K 60
++ +D SL D++ EK+ + QASE E K NL+ E +LE
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 61 EIAAISAETKETERQI-YQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFE 119
++ + ++ E+ + +Q+ + K H +++ + K L EN +L ++ E
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNH-ETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
Query: 120 EHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVK-KLKTMKEELMQ---DLQN 175
+ + + K +E+++S + E +++ D KL E L Q +L+
Sbjct: 1263 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1322
Query: 176 PGGNRITQVQ----------EDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEV 225
+ + Q+Q E KD + I+K L E ++ EKL ++I
Sbjct: 1323 ENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK---LNELRRQKEKLEEKIMD 1379
Query: 226 QHKRYD 231
Q+K YD
Sbjct: 1380 QYKFYD 1385
Score = 37.7 bits (86), Expect = 0.011
Identities = 50/251 (19%), Positives = 105/251 (41%), Gaps = 31/251 (12%)
Query: 35 QSQASEIEKNKKVLFNLK--------------NELHELEKEIAAISAETKETERQIYQQD 80
+++ E++++ +VL K ++LHELEKE + A+ + E +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 81 SAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLG 140
IE +LE K E++ L +++E E +A + SLG
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-----------LSEAPQKSLG 451
Query: 141 EVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGN--RITQVQEDITNLKDKIITV 198
++ + L + + KT+ EEL + + GN +I +++++ L K+ +
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTV-EELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 199 KESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNR---RQWQWNI 255
+ I+++ L+ + + L KE K + + + Q+ L+ Q ++
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 256 QQLEKTAAELR 266
+Q + +AE R
Sbjct: 571 RQRSQISAEAR 581
Score = 37.4 bits (85), Expect = 0.014
Identities = 51/264 (19%), Positives = 104/264 (39%), Gaps = 34/264 (12%)
Query: 15 EDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETER 74
+ QD + + ++ + E ++ + L +K+ L E+E+ A + AE +
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ---- 1063
Query: 75 QIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE---DFEEHMIKYNAYYAK 131
+L+TQ+K L ++N L+ I Q +E AK
Sbjct: 1064 -----------------ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1106
Query: 132 IKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGG--NRITQVQEDIT 189
++ ++L + S M + + L+ E ++++ ++ + + + E +
Sbjct: 1107 LQVENSTLNSQST--SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1164
Query: 190 NLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILK---RLHCQVNKLQS 246
L ++ + ES+I K L K H+ L E RY+ +LK +L L+
Sbjct: 1165 LLHERQASEYESLISKHGTL---KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 247 NRRQWQWNIQQLEKTAAELRKCIG 270
+ + + E AAE +K G
Sbjct: 1222 EQEKMLLENKNHETVAAEYKKLCG 1245
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 57.0 bits (136), Expect = 2e-08
Identities = 56/268 (20%), Positives = 122/268 (45%), Gaps = 28/268 (10%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVL----FNLKNELHELEK 60
+E K++ K N+ ++D E++ K+++++ E+EK K+ L +L++++ EL+
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR-QELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
+I + + + E ++ + ++ LH ++ ++ L ++ +L QEDFE
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL-------QEDFES 1129
Query: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFV---KKLKTMKEELMQDLQNPG 177
N KA K E + TEL + D ++L+T +E+ + +L+
Sbjct: 1130 EKASRN------KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 178 GNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRL 237
+ I +++ + T E + E+ + K EK ++ +E + K L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN-------KEL 1236
Query: 238 HCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
C+V LQ + + + ++L+ EL
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Score = 50.1 bits (118), Expect = 2e-06
Identities = 60/244 (24%), Positives = 103/244 (42%), Gaps = 43/244 (17%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+ ERK Q +E N L E A+ ++ +A K ++ L+ LH+LE +
Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQE----LEEILHDLESRV 931
Query: 63 AAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHM 122
E +E QI Q + + + H LE Q+ KL+ + TA+
Sbjct: 932 -----EEEEERNQILQNEK--KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE------- 977
Query: 123 IKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRIT 182
AKIK + + +E + S F+K+ K M++ + + +++
Sbjct: 978 -------AKIKKMEEEILLLEDQNS---------KFIKEKKLMEDRIAEC-----SSQLA 1016
Query: 183 QVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVN 242
+ +E NL KI +E +I LEE K EK R+E+E ++ D L Q+
Sbjct: 1017 EEEEKAKNLA-KIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 243 KLQS 246
+LQ+
Sbjct: 1073 ELQA 1076
Score = 48.1 bits (113), Expect = 8e-06
Identities = 56/269 (20%), Positives = 110/269 (40%), Gaps = 20/269 (7%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+ E+K F K+ S L D E + +++ Q + + L KN L E ++E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQE-LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 63 AAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHM 122
K E+Q+ S + +TK D I+SL KL D E + EE
Sbjct: 1356 ---EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 123 IKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRIT 182
+ Y+ K++ KN L + +L +R L+ +++ Q L
Sbjct: 1413 LAYD----KLEKTKNRLQQELD--DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 183 QVQE------DITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKR 236
+E + + K +++ ++ E EE ++ +++LR ++E D + K
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 237 LHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
+H +L+ ++R + ++++ EL
Sbjct: 1527 VH----ELEKSKRALEQQVEEMRTQLEEL 1551
Score = 42.7 bits (99), Expect = 3e-04
Identities = 46/252 (18%), Positives = 107/252 (42%), Gaps = 13/252 (5%)
Query: 24 ADAVEKVAKQQQSQA---SEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQD 80
A A+E++++Q + + +EKNK+ L EL K + + AE++ +++ Q
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 81 SAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLG 140
+ D L ++ S+ ++ T E+ E+ IK+ A +++
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 141 EVESKWSFMTELHEKRDFVKKLKTMKEE--LMQDLQNPGGNRITQVQEDITNLKDKIITV 198
E+ E +K + +++ ++EE +Q+ Q +++ + L+ ++
Sbjct: 1322 EL-----LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 199 KESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYD---AILKRLHCQVNKLQSNRRQWQWNI 255
K+ + + +E ++ +KL K+ E +R + +L N+LQ ++
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 256 QQLEKTAAELRK 267
+ A+ L K
Sbjct: 1437 DHQRQVASNLEK 1448
Score = 40.8 bits (94), Expect = 0.001
Identities = 50/242 (20%), Positives = 103/242 (42%), Gaps = 15/242 (6%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ Q++ E+ K K+ ++ EL E+E++ + E Q+ +
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 87 KLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEV--ES 144
+ + ++ + E ++ D+E+ E+ EE K++AH L E E
Sbjct: 907 ----EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 145 KWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIE 204
+ + EK K+K M+EE++ L++ I + + ++D+I + E
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILL-LEDQNSKFIKEKKL----MEDRIAECSSQLAE 1017
Query: 205 KTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
+ EE+ K K+R + EV + LK+ +L+ +R+ L+ AE
Sbjct: 1018 E----EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073
Query: 265 LR 266
L+
Sbjct: 1074 LQ 1075
Score = 39.3 bits (90), Expect = 0.004
Identities = 51/262 (19%), Positives = 99/262 (37%), Gaps = 18/262 (6%)
Query: 19 DTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQ 78
D L +E K + ++ K + + + + EL E I A++KE+E+++
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 79 QDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNS 138
++ I + S E + E +L +I + + + A+I +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 139 LGEVESKWSFMTELHEKRDFVKKLKTMKEELM-------------QDLQNPGGNRITQVQ 185
L E +S + + K ++ T+ EL Q L+ ++Q
Sbjct: 1745 LEEEQSNMELLNDRFRKTTL--QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 186 EDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQ 245
E +K K ++ K LEE+ + K R +R + LK + QV +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV---E 1859
Query: 246 SNRRQWQWNIQQLEKTAAELRK 267
RR +Q+EK A +++
Sbjct: 1860 DERRHADQYKEQMEKANARMKQ 1881
Score = 37.7 bits (86), Expect = 0.011
Identities = 54/286 (18%), Positives = 127/286 (44%), Gaps = 38/286 (13%)
Query: 8 KSQGFPKEDNQDTSSLADAVEKV--AKQQ-QSQASEIEKNKKVLFNLKNEL----HELEK 60
+++ +E SLA A+E+ AK++ + Q ++ + + L + K+++ HELEK
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
A+ + +E Q+ + + ++ T+ LE ++++ ++ + D++T E EE
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ---FERDLQTRDEQNEE 1589
Query: 121 HMIKYNAYYAKIKA-----HKNSLGEVESKWSFMTEL----------HEKRDFV----KK 161
+++A K V SK +L ++ RD V +K
Sbjct: 1590 KKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 162 LKTMKEELMQDLQNPGGNR------ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKT 215
L+ ++ ++L+ +R + ++ + +L+ +I+ ++E + ++
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE 1709
Query: 216 HEKLRKEIEVQHKRYDAIL---KRLHCQVNKLQSNRRQWQWNIQQL 258
++L EI A+L +RL ++ +L+ + Q N++ L
Sbjct: 1710 RDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 37.7 bits (86), Expect = 0.011
Identities = 27/111 (24%), Positives = 53/111 (47%), Gaps = 7/111 (6%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELE-------KEIAAIS 66
K DN E AK Q+ + + K K + L+ ++ +LE KE AA +
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 67 AETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQED 117
+ TE+++ + +E+ + H D + Q++ ++ +LK +E A+E+
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Score = 28.5 bits (62), Expect = 6.6
Identities = 15/72 (20%), Positives = 32/72 (44%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
VE + ++EK + LK +L E E+E +A ++ +R++ A E
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 87 KLHCDSLETQIK 98
+L+ +++
Sbjct: 1918 SREVSTLKNRLR 1929
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.0 bits (136), Expect = 2e-08
Identities = 58/268 (21%), Positives = 116/268 (43%), Gaps = 20/268 (7%)
Query: 1 MSDNKERKSQGFP--KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHEL 58
+ KE+ +G K + T L + + + + Q +E + K + L++EL +L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 59 EKEIAAISA---ETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQ 115
E E + E K + +++ Q + ++ + LE K L EN +L+ E
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 116 EDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELH-EKRDFVKK-------LKTMKE 167
EE+ +K + K +G + + EL E ++ VK+ L T++E
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 168 ELMQD-----LQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKE 222
+L+ + N ++T E I K++++ ++S ++ L E K L+K
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL--ESKLESTLKKS 967
Query: 223 IEVQHKRYDAILKRLHCQVNKLQSNRRQ 250
+E++ ++ A+ RL N Q R++
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQE 995
Score = 53.1 bits (126), Expect = 2e-07
Identities = 62/284 (21%), Positives = 124/284 (43%), Gaps = 29/284 (10%)
Query: 15 EDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKE------------- 61
E ++TSS +E +Q + + ++ + L+NELH LEKE
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 62 ----IAAISAETKETERQ---IYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETA 114
I A+ E E ER+ + + + +N +SLE + L EN++L+ ++E+
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 115 QEDFEEHMIKYNAYYAKIKAHKNSLGE-VESKWSFMTELHEKRDFVKKLKTMKEELMQDL 173
+ M + ++++ K L + +E + + + L + L + L
Sbjct: 714 -KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 174 QNPGGNRITQVQEDITNLKDKIITVKESIIE------KTCFLEEEKKTHEKLRKEIEVQH 227
+N +I Q++ ++ +L+ + T+++++ E + LE+E K+ E+ ++E
Sbjct: 773 EN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 228 KRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGM 271
K+ + KRL Q + + I LEK L K IG+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Score = 53.1 bits (126), Expect = 2e-07
Identities = 52/239 (21%), Positives = 108/239 (45%), Gaps = 7/239 (2%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+N +K Q E QD ++K ++ + + +E+ +K +L+ E +LEK+
Sbjct: 773 ENSNKKIQQLESE-LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 63 AAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEH- 121
+ E K +Q +D+ +E + +LE + K+L E K +E +E+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 122 -MIKYNAYYAK--IKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGG 178
++K K + ++ + E +L + ++K+ KE L+ D Q+
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD- 950
Query: 179 NRITQVQEDITNLKDKIITVKES-IIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKR 236
+R ++ + + K + +KE I LEE +++LR+E++ K Y+A+ +R
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/318 (21%), Positives = 136/318 (42%), Gaps = 70/318 (22%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF----NLKNELH 56
+ +N ER+ + +E+ +++ ++ +++ +IEK K+L ++L
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 57 ELEKEIAAISAE----------TKETERQIYQQD-------SAIENTKLHC---DSLETQ 96
++E E I E +E E +++ + I N K+ C ++LE +
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 97 IKSLHSENVKLK---------------FDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE 141
L EN KLK + E +Q D E ++ N K + K + +
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 142 VESKWSFMTELHEKRDFVKK-LKTMKEELMQ-----------DLQNPGGNRITQVQEDIT 189
+E+K EL +++ +KK L+ +K + D++N ++Q+ +
Sbjct: 725 LENK-----ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN------QRLQKTLE 773
Query: 190 NLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRR 249
N KI ++ + + LE E +T +K +E+++ KR L++L + L+
Sbjct: 774 NSNKKIQQLESELQD----LEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETS 825
Query: 250 QWQWNIQQLEKTAAELRK 267
Q + + +QLEK LR+
Sbjct: 826 QLEKDKKQLEKENKRLRQ 843
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/293 (20%), Positives = 137/293 (46%), Gaps = 35/293 (11%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLK---NELHEL 58
S+ E + E N+ TSS + K+ + QS +E+ + + +++ +++ ++
Sbjct: 440 SELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 59 EKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDF 118
EKE +S + + E +I Q+ +++N C +L K L E +L+ IET +E+
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQN----CQNLS---KDLMKEKAQLEKTIETLRENS 549
Query: 119 E----------EHM---IKYNAYYAKIKAHKNSLGEVESKWSFMTE-LHEKRDFVKKLKT 164
E EH+ + ++I A + ++E + + E + E + K++
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKENKILHESIKETSSKLSKIEF 608
Query: 165 MKEELMQDLQN--PGGNRITQVQEDITNL--KDKIITVKESIIEKTC-FLEEEKKTHEKL 219
K ++ ++L++ G R +++ ++ +L +++++ K + ++ TC +E ++ + +L
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 220 RKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQ 272
+E K D+ K L Q+ L+ Q +L + L KC M+
Sbjct: 669 ERENRKLKKTLDS-FKNLTFQLESLEKENSQLDEENLELRRNVESL-KCASMK 719
Score = 44.3 bits (103), Expect = 1e-04
Identities = 63/290 (21%), Positives = 129/290 (44%), Gaps = 37/290 (12%)
Query: 3 DNK-ERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKE 61
DNK ER+SQ E ++ + D + +V + + +E + K L L+ + + L+ +
Sbjct: 1026 DNKWERESQ----ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1081
Query: 62 IAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEH 121
I A+ +T + Q + ++ +L +Q SL ++N +L +++ E+ E
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ-QSSLENENES 1140
Query: 122 MIKY-----NAYYAKIK-------AHKNSLGEVES---KWSFMTELH-----EKRDFVKK 161
+IK + Y + IK H+ E ES K + H E RD +
Sbjct: 1141 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1200
Query: 162 LKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEE-KKTHEK 218
+ ++ ++DL+ ++ +V+++ L++K + +K C + T+ +
Sbjct: 1201 YNQLLKQKGQLEDLE-----KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 219 LRKEIEV---QHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
L KE EV HK ++L + +L++ + + QQL+ T+ +L
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1305
Score = 38.9 bits (89), Expect = 0.005
Identities = 55/246 (22%), Positives = 104/246 (42%), Gaps = 33/246 (13%)
Query: 15 EDNQDTSSLADAV----EKVAKQQQSQASEIEKN-------KKVLFNLKNELHELE---K 60
++ +D SL D++ EK+ + QASE E K NL+ E +LE
Sbjct: 1143 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1202
Query: 61 EIAAISAETKETERQI-YQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFE 119
++ + ++ E+ + +Q+ + K H +++ + K L EN +L ++ E
Sbjct: 1203 QLLKQKGQLEDLEKMLKVEQEKMLLENKNH-ETVAAEYKKLCGENDRLNHTYSQLLKETE 1261
Query: 120 EHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVK-KLKTMKEELMQ---DLQN 175
+ + + K +E+++S + E +++ D KL E L Q +L+
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Query: 176 PGGNRITQVQ----------EDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEV 225
+ + Q+Q E KD + I+K L E ++ EKL ++I
Sbjct: 1322 ENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK---LNELRRQKEKLEEKIMD 1378
Query: 226 QHKRYD 231
Q+K YD
Sbjct: 1379 QYKFYD 1384
Score = 37.7 bits (86), Expect = 0.011
Identities = 50/251 (19%), Positives = 105/251 (41%), Gaps = 31/251 (12%)
Query: 35 QSQASEIEKNKKVLFNLK--------------NELHELEKEIAAISAETKETERQIYQQD 80
+++ E++++ +VL K ++LHELEKE + A+ + E +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 81 SAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLG 140
IE +LE K E++ L +++E E +A + SLG
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-----------LSEAPQKSLG 451
Query: 141 EVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGN--RITQVQEDITNLKDKIITV 198
++ + L + + KT+ EEL + + GN +I +++++ L K+ +
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTV-EELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 199 KESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNR---RQWQWNI 255
+ I+++ L+ + + L KE K + + + Q+ L+ Q ++
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 256 QQLEKTAAELR 266
+Q + +AE R
Sbjct: 571 RQRSQISAEAR 581
Score = 37.4 bits (85), Expect = 0.014
Identities = 51/264 (19%), Positives = 104/264 (39%), Gaps = 34/264 (12%)
Query: 15 EDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETER 74
+ QD + + ++ + E ++ + L +K+ L E+E+ A + AE +
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ---- 1062
Query: 75 QIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE---DFEEHMIKYNAYYAK 131
+L+TQ+K L ++N L+ I Q +E AK
Sbjct: 1063 -----------------ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
Query: 132 IKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGG--NRITQVQEDIT 189
++ ++L + S M + + L+ E ++++ ++ + + + E +
Sbjct: 1106 LQVENSTLNSQST--SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
Query: 190 NLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILK---RLHCQVNKLQS 246
L ++ + ES+I K L K H+ L E RY+ +LK +L L+
Sbjct: 1164 LLHERQASEYESLISKHGTL---KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220
Query: 247 NRRQWQWNIQQLEKTAAELRKCIG 270
+ + + E AAE +K G
Sbjct: 1221 EQEKMLLENKNHETVAAEYKKLCG 1244
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 55.8 bits (133), Expect = 4e-08
Identities = 52/253 (20%), Positives = 113/253 (44%), Gaps = 24/253 (9%)
Query: 28 EKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTK 87
E++ + + + KNK L L + + E + A+ E Q + ++ K
Sbjct: 1039 EELRLARDANSENCNKNKF----LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAK 1094
Query: 88 LHCDSLETQIKSLHSENVKLKFDIE-------TAQEDFEEHMIKYNAYYAKIKAHKNSLG 140
+ D QIK L+ + +L ++IE + ++ F++ Y+ + K +LG
Sbjct: 1095 QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG 1154
Query: 141 --EVESKWSFMT---ELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKI 195
++ES+ + E+ R +++ T K E +L NRI + + T ++
Sbjct: 1155 WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK-ASNRIQESKNQCT----QV 1209
Query: 196 ITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDA---ILKRLHCQVNKLQSNRRQWQ 252
+ +ES++ K LE++K ++L E+ +A + +RL C+ ++Q++ QW+
Sbjct: 1210 VQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK 1269
Query: 253 WNIQQLEKTAAEL 265
+ E+ ++
Sbjct: 1270 TQYSRKEEAIRKI 1282
Score = 40.0 bits (92), Expect = 0.002
Identities = 50/251 (19%), Positives = 111/251 (44%), Gaps = 21/251 (8%)
Query: 8 KSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISA 67
K G KE N+ + L +E ++++S ++ K L+ + + EKE +
Sbjct: 1099 KCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ-KARQCEKE--NLGW 1155
Query: 68 ETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNA 127
+ E+E+ I +++ IE ++ T+ + +E K I+ ++ + + + +
Sbjct: 1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERES 1215
Query: 128 YYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQED 187
KIK + ++ EL+ + ++ +K+ L + Q Q+Q D
Sbjct: 1216 LLVKIKVLEQDKARLQR---LEDELNRAKSTLEAETRVKQRLECEKQ--------QIQND 1264
Query: 188 ITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRL--HCQVNKLQ 245
+ K + + KE I K +E E++ E+ + + + +R A +KR+ C+ KL+
Sbjct: 1265 LNQWKTQ-YSRKEEAIRK---IESEREKSEREKNSLRSEIERLQAEIKRIEERCR-RKLE 1319
Query: 246 SNRRQWQWNIQ 256
+ R+ Q ++
Sbjct: 1320 DSTRETQSQLE 1330
Score = 35.0 bits (79), Expect = 0.070
Identities = 50/275 (18%), Positives = 117/275 (42%), Gaps = 29/275 (10%)
Query: 14 KEDNQDTSSLADA--VEKVAKQQQSQASEI-------EKNKKVLFNLKNELHELEKEIAA 64
++D+ ++ D+ V + +Q++ SEI E+ +K+ N + + E ++A+
Sbjct: 908 RQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLAS 967
Query: 65 ISAETKET-----ERQIYQQDSAI---ENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + +R + Q S + E +H +E +S + + ++ + E
Sbjct: 968 YTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS--GDYYRFLSEMLKSLE 1025
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEK-----RDFVKKLKTMKEELMQ 171
D + K +++ +++ E +K F+ + +K F KL ++ EEL +
Sbjct: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL-EELKR 1084
Query: 172 DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYD 231
+ G + ++++ +I + E I T +E+EK+ + + + Q YD
Sbjct: 1085 QAELDGKS----AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
Query: 232 AILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
+ K C+ L + + + I++ E LR
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR 1175
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 55.8 bits (133), Expect = 4e-08
Identities = 58/261 (22%), Positives = 119/261 (45%), Gaps = 42/261 (16%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
+E K++ K N+ S +++ ++ K+++S+ E+EK K+ L ++ HE +IA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHE---QIAD 1073
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK 124
+ A+ E + Q+ +++ ++ D Q + + +L+ I QED +
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA- 1132
Query: 125 YNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQV 184
A+ KA K +KRD ++L+ +K EL L + T
Sbjct: 1133 -----ARNKAEK-----------------QKRDLGEELEALKTELEDTLDS------TAT 1164
Query: 185 QEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKL 244
Q+++ +++ +TV + L+EE ++HE +E+ +H + ++ L Q+ +
Sbjct: 1165 QQELRAKREQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQ---AVEELTEQLEQF 1215
Query: 245 QSNRRQWQWNIQQLEKTAAEL 265
+ + N Q LEK A+L
Sbjct: 1216 KRAKANLDKNKQTLEKENADL 1236
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/253 (22%), Positives = 118/253 (46%), Gaps = 16/253 (6%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ Q++ E++K K+ +NEL ELE++ + ++ E + Q+ + T
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE------T 900
Query: 87 KLHCDSLETQIK--SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE-VE 143
+L+ ++ E +++ + E ++ ++E E+ E+ + A K+ L E +E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 144 SKWSFMTELH-EKRDFVKKLKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKE 200
+ + +L EK K+K +++E+ M D N ++E I++L + +E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 201 SIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
K L + K HE + E+EV+ K+ + + L KL+ + + I L+
Sbjct: 1021 ----KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 261 TAAELRKCIGMQE 273
AEL+ + +E
Sbjct: 1077 QIAELKMQLAKKE 1089
Score = 48.1 bits (113), Expect = 8e-06
Identities = 49/275 (17%), Positives = 116/275 (42%), Gaps = 23/275 (8%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
N+ G E LA V ++ Q Q +++ + N+ +L +LE+E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 64 AISAETKET-------ERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + E ER I + + ++K + +++L + + +IE +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQ----- 171
+EE A Y K++ KN L + + +L +R V L+ + + Q
Sbjct: 1407 QYEEKA----AAYDKLEKTKNRLQQELD--DLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 172 -DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRY 230
++ + + + + + + K +++ ++ E EE ++T++ L+ E+E
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1520
Query: 231 DAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
D + K +H +L+ ++R + +++++ EL
Sbjct: 1521 DDVGKNVH----ELEKSKRALETQMEEMKTQLEEL 1551
Score = 42.0 bits (97), Expect = 6e-04
Identities = 60/294 (20%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF-----------N 50
+D ++R ++ +E SLA A+E+ + ++ E+E+ K+L +
Sbjct: 1468 ADERDR-AEAEAREKETKALSLARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDD 1522
Query: 51 LKNELHELEKEIAAISAETKETERQIYQQD---SAIENTKLHCD--------SLETQIKS 99
+ +HELEK A+ + +E + Q+ + + A E+ KL + E +++
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 100 LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSL-GEVES-KWSFMTELHEKRD 157
+N + + ++ ++E + A A K L G+++ + + + + +
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 158 FVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII-TVKE------SIIEKTCFLE 210
+K+L+ ++ + M+D Q + ED +D+I T KE S+ L+
Sbjct: 1643 AIKQLRKLQAQ-MKDFQ--------RELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 211 EEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
E+ E+ RK+ +++ + L N LQ +R+ + I QLE+ E
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/246 (18%), Positives = 105/246 (42%), Gaps = 29/246 (11%)
Query: 24 ADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAI 83
A+ +KV K Q +E+E +L + + +L K++A++S++ ++T+ + ++
Sbjct: 1276 AELNDKVHKLQ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 84 ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVE 143
N LE + SL + L ++E A+++ E H+ N + K
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQ---LDEEME-AKQNLERHISTLNIQLSDSKK--------- 1378
Query: 144 SKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESII 203
+L + V+ L+ K+ ++++N +TQ E+ DK+ K +
Sbjct: 1379 -------KLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 204 EKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAA 263
++ L + +L +E + +++D +L +K R + + ++ E A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 264 ELRKCI 269
L + +
Sbjct: 1487 SLARAL 1492
Score = 30.4 bits (67), Expect = 1.7
Identities = 33/175 (18%), Positives = 69/175 (39%), Gaps = 15/175 (8%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-----KNKKVLFNLKNELHELEKEIAAISAETKET 72
Q S +E+ K+ +S+ E+E K K + L+ ++ +LE+++ + E +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 73 ERQIYQQDSAIENTKLHCDS----LETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAY 128
+ + Q+D ++ L + E + N ++K ++ E+ EE + NA
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-QLKRQLEEAEEESQRINAN 1899
Query: 129 YAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQ 183
K++ + E E KL+ E + GG R+ +
Sbjct: 1900 RRKLQRELDEATESNEAMG-----REVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 55.8 bits (133), Expect = 4e-08
Identities = 58/261 (22%), Positives = 119/261 (45%), Gaps = 42/261 (16%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
+E K++ K N+ S +++ ++ K+++S+ E+EK K+ L ++ HE +IA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHE---QIAD 1080
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK 124
+ A+ E + Q+ +++ ++ D Q + + +L+ I QED +
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA- 1139
Query: 125 YNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQV 184
A+ KA K +KRD ++L+ +K EL L + T
Sbjct: 1140 -----ARNKAEK-----------------QKRDLGEELEALKTELEDTLDS------TAT 1171
Query: 185 QEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKL 244
Q+++ +++ +TV + L+EE ++HE +E+ +H + ++ L Q+ +
Sbjct: 1172 QQELRAKREQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQ---AVEELTEQLEQF 1222
Query: 245 QSNRRQWQWNIQQLEKTAAEL 265
+ + N Q LEK A+L
Sbjct: 1223 KRAKANLDKNKQTLEKENADL 1243
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/253 (22%), Positives = 118/253 (46%), Gaps = 16/253 (6%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ Q++ E++K K+ +NEL ELE++ + ++ E + Q+ + T
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE------T 907
Query: 87 KLHCDSLETQIK--SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE-VE 143
+L+ ++ E +++ + E ++ ++E E+ E+ + A K+ L E +E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 144 SKWSFMTELH-EKRDFVKKLKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKE 200
+ + +L EK K+K +++E+ M D N ++E I++L + +E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 201 SIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
K L + K HE + E+EV+ K+ + + L KL+ + + I L+
Sbjct: 1028 ----KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 261 TAAELRKCIGMQE 273
AEL+ + +E
Sbjct: 1084 QIAELKMQLAKKE 1096
Score = 48.1 bits (113), Expect = 8e-06
Identities = 49/275 (17%), Positives = 116/275 (42%), Gaps = 23/275 (8%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
N+ G E LA V ++ Q Q +++ + N+ +L +LE+E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 64 AISAETKET-------ERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + E ER I + + ++K + +++L + + +IE +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQ----- 171
+EE A Y K++ KN L + + +L +R V L+ + + Q
Sbjct: 1414 QYEEKA----AAYDKLEKTKNRLQQELD--DLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 172 -DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRY 230
++ + + + + + + K +++ ++ E EE ++T++ L+ E+E
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1527
Query: 231 DAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
D + K +H +L+ ++R + +++++ EL
Sbjct: 1528 DDVGKNVH----ELEKSKRALETQMEEMKTQLEEL 1558
Score = 42.0 bits (97), Expect = 6e-04
Identities = 60/294 (20%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF-----------N 50
+D ++R ++ +E SLA A+E+ + ++ E+E+ K+L +
Sbjct: 1475 ADERDR-AEAEAREKETKALSLARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDD 1529
Query: 51 LKNELHELEKEIAAISAETKETERQIYQQD---SAIENTKLHCD--------SLETQIKS 99
+ +HELEK A+ + +E + Q+ + + A E+ KL + E +++
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 100 LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSL-GEVES-KWSFMTELHEKRD 157
+N + + ++ ++E + A A K L G+++ + + + + +
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 158 FVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII-TVKE------SIIEKTCFLE 210
+K+L+ ++ + M+D Q + ED +D+I T KE S+ L+
Sbjct: 1650 AIKQLRKLQAQ-MKDFQ--------RELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 211 EEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
E+ E+ RK+ +++ + L N LQ +R+ + I QLE+ E
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/246 (18%), Positives = 105/246 (42%), Gaps = 29/246 (11%)
Query: 24 ADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAI 83
A+ +KV K Q +E+E +L + + +L K++A++S++ ++T+ + ++
Sbjct: 1283 AELNDKVHKLQ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 84 ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVE 143
N LE + SL + L ++E A+++ E H+ N + K
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQ---LDEEME-AKQNLERHISTLNIQLSDSKK--------- 1385
Query: 144 SKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESII 203
+L + V+ L+ K+ ++++N +TQ E+ DK+ K +
Sbjct: 1386 -------KLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 204 EKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAA 263
++ L + +L +E + +++D +L +K R + + ++ E A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 264 ELRKCI 269
L + +
Sbjct: 1494 SLARAL 1499
Score = 30.4 bits (67), Expect = 1.7
Identities = 33/175 (18%), Positives = 69/175 (39%), Gaps = 15/175 (8%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-----KNKKVLFNLKNELHELEKEIAAISAETKET 72
Q S +E+ K+ +S+ E+E K K + L+ ++ +LE+++ + E +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 73 ERQIYQQDSAIENTKLHCDS----LETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAY 128
+ + Q+D ++ L + E + N ++K ++ E+ EE + NA
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-QLKRQLEEAEEESQRINAN 1906
Query: 129 YAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQ 183
K++ + E E KL+ E + GG R+ +
Sbjct: 1907 RRKLQRELDEATESNEAMG-----REVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 55.8 bits (133), Expect = 4e-08
Identities = 58/261 (22%), Positives = 119/261 (45%), Gaps = 42/261 (16%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
+E K++ K N+ S +++ ++ K+++S+ E+EK K+ L ++ HE +IA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHE---QIAD 1080
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK 124
+ A+ E + Q+ +++ ++ D Q + + +L+ I QED +
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA- 1139
Query: 125 YNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQV 184
A+ KA K +KRD ++L+ +K EL L + T
Sbjct: 1140 -----ARNKAEK-----------------QKRDLGEELEALKTELEDTLDS------TAT 1171
Query: 185 QEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKL 244
Q+++ +++ +TV + L+EE ++HE +E+ +H + ++ L Q+ +
Sbjct: 1172 QQELRAKREQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQ---AVEELTEQLEQF 1222
Query: 245 QSNRRQWQWNIQQLEKTAAEL 265
+ + N Q LEK A+L
Sbjct: 1223 KRAKANLDKNKQTLEKENADL 1243
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/253 (22%), Positives = 118/253 (46%), Gaps = 16/253 (6%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ Q++ E++K K+ +NEL ELE++ + ++ E + Q+ + T
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE------T 907
Query: 87 KLHCDSLETQIK--SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE-VE 143
+L+ ++ E +++ + E ++ ++E E+ E+ + A K+ L E +E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 144 SKWSFMTELH-EKRDFVKKLKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKE 200
+ + +L EK K+K +++E+ M D N ++E I++L + +E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 201 SIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
K L + K HE + E+EV+ K+ + + L KL+ + + I L+
Sbjct: 1028 ----KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 261 TAAELRKCIGMQE 273
AEL+ + +E
Sbjct: 1084 QIAELKMQLAKKE 1096
Score = 48.1 bits (113), Expect = 8e-06
Identities = 49/275 (17%), Positives = 116/275 (42%), Gaps = 23/275 (8%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
N+ G E LA V ++ Q Q +++ + N+ +L +LE+E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 64 AISAETKET-------ERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + E ER I + + ++K + +++L + + +IE +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQ----- 171
+EE A Y K++ KN L + + +L +R V L+ + + Q
Sbjct: 1414 QYEEKA----AAYDKLEKTKNRLQQELD--DLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 172 -DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRY 230
++ + + + + + + K +++ ++ E EE ++T++ L+ E+E
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1527
Query: 231 DAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
D + K +H +L+ ++R + +++++ EL
Sbjct: 1528 DDVGKNVH----ELEKSKRALETQMEEMKTQLEEL 1558
Score = 42.0 bits (97), Expect = 6e-04
Identities = 60/294 (20%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF-----------N 50
+D ++R ++ +E SLA A+E+ + ++ E+E+ K+L +
Sbjct: 1475 ADERDR-AEAEAREKETKALSLARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDD 1529
Query: 51 LKNELHELEKEIAAISAETKETERQIYQQD---SAIENTKLHCD--------SLETQIKS 99
+ +HELEK A+ + +E + Q+ + + A E+ KL + E +++
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 100 LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSL-GEVES-KWSFMTELHEKRD 157
+N + + ++ ++E + A A K L G+++ + + + + +
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 158 FVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII-TVKE------SIIEKTCFLE 210
+K+L+ ++ + M+D Q + ED +D+I T KE S+ L+
Sbjct: 1650 AIKQLRKLQAQ-MKDFQ--------RELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 211 EEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
E+ E+ RK+ +++ + L N LQ +R+ + I QLE+ E
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/246 (18%), Positives = 105/246 (42%), Gaps = 29/246 (11%)
Query: 24 ADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAI 83
A+ +KV K Q +E+E +L + + +L K++A++S++ ++T+ + ++
Sbjct: 1283 AELNDKVHKLQ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 84 ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVE 143
N LE + SL + L ++E A+++ E H+ N + K
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQ---LDEEME-AKQNLERHISTLNIQLSDSKK--------- 1385
Query: 144 SKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESII 203
+L + V+ L+ K+ ++++N +TQ E+ DK+ K +
Sbjct: 1386 -------KLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 204 EKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAA 263
++ L + +L +E + +++D +L +K R + + ++ E A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 264 ELRKCI 269
L + +
Sbjct: 1494 SLARAL 1499
Score = 28.9 bits (63), Expect = 5.0
Identities = 22/112 (19%), Positives = 53/112 (47%), Gaps = 12/112 (10%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-----KNKKVLFNLKNELHELEKEIAAISAETKET 72
Q S +E+ K+ +S+ E+E K K + L+ ++ +LE+++ + E +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 73 ERQIYQQDS-------AIENTKLHCDSLETQIKSLHSENVKLKFDIETAQED 117
+ + Q+D +E+ + + + Q + ++ +LK +E A+E+
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 55.8 bits (133), Expect = 4e-08
Identities = 58/261 (22%), Positives = 119/261 (45%), Gaps = 42/261 (16%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
+E K++ K N+ S +++ ++ K+++S+ E+EK K+ L ++ HE +IA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHE---QIAD 1073
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK 124
+ A+ E + Q+ +++ ++ D Q + + +L+ I QED +
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA- 1132
Query: 125 YNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQV 184
A+ KA K +KRD ++L+ +K EL L + T
Sbjct: 1133 -----ARNKAEK-----------------QKRDLGEELEALKTELEDTLDS------TAT 1164
Query: 185 QEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKL 244
Q+++ +++ +TV + L+EE ++HE +E+ +H + ++ L Q+ +
Sbjct: 1165 QQELRAKREQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQ---AVEELTEQLEQF 1215
Query: 245 QSNRRQWQWNIQQLEKTAAEL 265
+ + N Q LEK A+L
Sbjct: 1216 KRAKANLDKNKQTLEKENADL 1236
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/253 (22%), Positives = 118/253 (46%), Gaps = 16/253 (6%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
V + ++ Q++ E++K K+ +NEL ELE++ + ++ E + Q+ + T
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE------T 900
Query: 87 KLHCDSLETQIK--SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE-VE 143
+L+ ++ E +++ + E ++ ++E E+ E+ + A K+ L E +E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 144 SKWSFMTELH-EKRDFVKKLKTMKEEL--MQDLQNPGGNRITQVQEDITNLKDKIITVKE 200
+ + +L EK K+K +++E+ M D N ++E I++L + +E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 201 SIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
K L + K HE + E+EV+ K+ + + L KL+ + + I L+
Sbjct: 1021 ----KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 261 TAAELRKCIGMQE 273
AEL+ + +E
Sbjct: 1077 QIAELKMQLAKKE 1089
Score = 48.1 bits (113), Expect = 8e-06
Identities = 49/275 (17%), Positives = 116/275 (42%), Gaps = 23/275 (8%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
N+ G E LA V ++ Q Q +++ + N+ +L +LE+E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 64 AISAETKET-------ERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + E ER I + + ++K + +++L + + +IE +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQ----- 171
+EE A Y K++ KN L + + +L +R V L+ + + Q
Sbjct: 1407 QYEEKA----AAYDKLEKTKNRLQQELD--DLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 172 -DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRY 230
++ + + + + + + K +++ ++ E EE ++T++ L+ E+E
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1520
Query: 231 DAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
D + K +H +L+ ++R + +++++ EL
Sbjct: 1521 DDVGKNVH----ELEKSKRALETQMEEMKTQLEEL 1551
Score = 42.0 bits (97), Expect = 6e-04
Identities = 60/294 (20%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 2 SDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF-----------N 50
+D ++R ++ +E SLA A+E+ + ++ E+E+ K+L +
Sbjct: 1468 ADERDR-AEAEAREKETKALSLARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDD 1522
Query: 51 LKNELHELEKEIAAISAETKETERQIYQQD---SAIENTKLHCD--------SLETQIKS 99
+ +HELEK A+ + +E + Q+ + + A E+ KL + E +++
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 100 LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSL-GEVES-KWSFMTELHEKRD 157
+N + + ++ ++E + A A K L G+++ + + + + +
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 158 FVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII-TVKE------SIIEKTCFLE 210
+K+L+ ++ + M+D Q + ED +D+I T KE S+ L+
Sbjct: 1643 AIKQLRKLQAQ-MKDFQ--------RELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 211 EEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
E+ E+ RK+ +++ + L N LQ +R+ + I QLE+ E
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/246 (18%), Positives = 105/246 (42%), Gaps = 29/246 (11%)
Query: 24 ADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAI 83
A+ +KV K Q +E+E +L + + +L K++A++S++ ++T+ + ++
Sbjct: 1276 AELNDKVHKLQ----NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 84 ENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVE 143
N LE + SL + L ++E A+++ E H+ N + K
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQ---LDEEME-AKQNLERHISTLNIQLSDSKK--------- 1378
Query: 144 SKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESII 203
+L + V+ L+ K+ ++++N +TQ E+ DK+ K +
Sbjct: 1379 -------KLQDFASTVEALEEGKKRFQKEIEN-----LTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 204 EKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAA 263
++ L + +L +E + +++D +L +K R + + ++ E A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 264 ELRKCI 269
L + +
Sbjct: 1487 SLARAL 1492
Score = 28.9 bits (63), Expect = 5.0
Identities = 22/112 (19%), Positives = 53/112 (47%), Gaps = 12/112 (10%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-----KNKKVLFNLKNELHELEKEIAAISAETKET 72
Q S +E+ K+ +S+ E+E K K + L+ ++ +LE+++ + E +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 73 ERQIYQQDS-------AIENTKLHCDSLETQIKSLHSENVKLKFDIETAQED 117
+ + Q+D +E+ + + + Q + ++ +LK +E A+E+
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 54.3 bits (129), Expect = 1e-07
Identities = 53/280 (18%), Positives = 121/280 (43%), Gaps = 32/280 (11%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
KE ++L +E+ + ++ ++ + + VL E ++E+ +S+E +
Sbjct: 1606 KEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALR 1665
Query: 74 RQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFE----EH-MIKYNAY 128
RQ+ Q+ +++ L + + I+ + K +IE Q E EH M++
Sbjct: 1666 RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELR 1725
Query: 129 YAKIKAHKNSLGEVES---KWSFMTELH-----------EKRDFVKKLKTMKEELMQDLQ 174
+++ G E+ K + + EL E + + L+ +E L Q+++
Sbjct: 1726 NLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE 1785
Query: 175 N------PGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHK 228
NRI + + T +++ +ES++ K LE++K ++L E+
Sbjct: 1786 KFQKQALEASNRIQESKNQCT----QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841
Query: 229 RYDA---ILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
+A + +RL C+ ++Q++ QW+ + E+ ++
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1881
Score = 39.7 bits (91), Expect = 0.003
Identities = 61/284 (21%), Positives = 125/284 (44%), Gaps = 40/284 (14%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNK----KVLFNLKNELHELEKEIAAISAET 69
KE + L +++ +++ +E+ K + + + NL+N+ +E E I T
Sbjct: 1165 KEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK-YETEINI------T 1217
Query: 70 KETERQI-YQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQED---FEEHMIKY 125
K T ++I Q++ +N + D L + + L E V+L I A E EE+ ++
Sbjct: 1218 KTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQ 1277
Query: 126 NAYYAKIKAHKNSLGEVESKWSFMTELHEK--------------RDFVKKLKTMKEELMQ 171
A ++I K L E+E K + +D K+++ +K E +
Sbjct: 1278 KACGSEIMQKKQHL-EIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE 1336
Query: 172 DLQNPGG--NRITQVQ----EDITNLKDKIIT----VKESIIEKTCFLEEEKKTHEKLRK 221
+ + N +++V+ E+I +LK++ T K +I + T EE+ +
Sbjct: 1337 EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQID 1396
Query: 222 EIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
+ +++ +KRL + + N R+ + +IQQ + T +E+
Sbjct: 1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440
Score = 38.5 bits (88), Expect = 0.006
Identities = 53/289 (18%), Positives = 115/289 (39%), Gaps = 39/289 (13%)
Query: 6 ERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAI 65
ER SQ +D QD + ++++++ Q+Q E+ + K+ + +LE+E+ +
Sbjct: 1543 ERVSQERTVKD-QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601
Query: 66 SAETKE---------------------TERQIYQQDSAIENTKLHCDSLETQIKSLHSEN 104
KE +E + QQ ++ + +++ L SE
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661
Query: 105 VKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKT 164
L+ + QE ++ ++ + I+ SL E + + + L E + K+
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE--NLTKEHLM 1719
Query: 165 MKEEL------MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEK 218
++EEL DL+ + I L+ ++ +E + + ++ E
Sbjct: 1720 LEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQREREN 1779
Query: 219 LRKEIE-VQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
LR+EIE Q + +A N++Q ++ Q +Q+ E +++
Sbjct: 1780 LRQEIEKFQKQALEA--------SNRIQESKNQCTQVVQERESLLVKIK 1820
Score = 38.1 bits (87), Expect = 0.008
Identities = 57/260 (21%), Positives = 115/260 (44%), Gaps = 44/260 (16%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK 60
+S+N+ + QG + ++ +L +EK KQ ++ I+++K + E L
Sbjct: 1758 ISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLV 1817
Query: 61 EIAAI---SAETKETERQIYQQDSAIENTKLHCDSLETQIKS-LHSENVKLKFDI---ET 113
+I + A + E ++ + S +E ET++K L E +++ D+ +T
Sbjct: 1818 KIKVLEQDKARLQRLEDELNRAKSTLE--------AETRVKQRLECEKQQIQNDLNQWKT 1869
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKNSL-GEVESKWSFMTELHEK---------RDFVKKLK 163
EE + K + K + KNSL E+E + + + E+ R+ +L+
Sbjct: 1870 QYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLE 1929
Query: 164 TMKEELMQDL----QNP-GGNRITQVQEDIT---------NLKDKIITVKE---SIIEKT 206
T + +++ Q P G +R TQ + + T L+ K+ ++ +I+KT
Sbjct: 1930 TERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT 1989
Query: 207 CF--LEEEKKTHEKLRKEIE 224
L + KK+ E++ EI+
Sbjct: 1990 TLDKLLKGKKSVEEVASEIQ 2009
Score = 35.0 bits (79), Expect = 0.070
Identities = 50/275 (18%), Positives = 117/275 (42%), Gaps = 29/275 (10%)
Query: 14 KEDNQDTSSLADA--VEKVAKQQQSQASEI-------EKNKKVLFNLKNELHELEKEIAA 64
++D+ ++ D+ V + +Q++ SEI E+ +K+ N + + E ++A+
Sbjct: 908 RQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLAS 967
Query: 65 ISAETKET-----ERQIYQQDSAI---ENTKLHCDSLETQIKSLHSENVKLKFDIETAQE 116
++ + +R + Q S + E +H +E +S + + ++ + E
Sbjct: 968 YTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS--GDYYRFLSEMLKSLE 1025
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEK-----RDFVKKLKTMKEELMQ 171
D + K +++ +++ E +K F+ + +K F KL ++ EEL +
Sbjct: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL-EELKR 1084
Query: 172 DLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYD 231
+ G + ++++ +I + E I T +E+EK+ + + + Q YD
Sbjct: 1085 QAELDGKS----AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
Query: 232 AILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
+ K C+ L + + + I++ E LR
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR 1175
Score = 34.3 bits (77), Expect = 0.12
Identities = 45/272 (16%), Positives = 115/272 (42%), Gaps = 28/272 (10%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAI-------S 66
K Q+ + L E+V++++ + +I + + L L+ + ++E+E+ + S
Sbjct: 1529 KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDS 1588
Query: 67 AETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYN 126
+ K+ E ++ +++ + +L Q++ + + D+ ++ + H+ +
Sbjct: 1589 CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQ 1648
Query: 127 AYYAKIK--------AHKNSLGEVES-KWSFMTELHEKRDFVKKLKTMKE-----ELMQD 172
+++ + L E ES K + + H ++ K +++ E E +Q
Sbjct: 1649 RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQS 1708
Query: 173 LQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDA 232
L ++E++ NL+ + ++ E ++ T +LR ++++ + R
Sbjct: 1709 LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD---SDKNATILELRSQLQISNNR--- 1762
Query: 233 ILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
L +N LQ R + I++ +K A E
Sbjct: 1763 -TLELQGLINDLQRERENLRQEIEKFQKQALE 1793
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 53.9 bits (128), Expect = 1e-07
Identities = 48/226 (21%), Positives = 105/226 (46%), Gaps = 41/226 (18%)
Query: 32 KQQQSQASEIEKNKKVLFNL----KNELHELEKEIAAISAETKETERQIYQQDSAIENTK 87
KQ + A E++ ++ L L + E+H+LE ++ AI+ + +++ + +EN K
Sbjct: 451 KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEK 510
Query: 88 L-------HCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLG 140
L HC+ L + K L E + +++ QED + K + L
Sbjct: 511 LKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNK----------KQEERMLK 560
Query: 141 EVESKWSFMTELHEKRDFVK-KLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVK 199
++E+ T+L + ++V+ +LK ++E+ ++ + +E+ NL +
Sbjct: 561 QIENLQETETQLRNELEYVREELKQKRDEVK--------CKLDKSEENCNNL-------R 605
Query: 200 ESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQ 245
+ + K ++EE ++ ++ L+K+ + K+ L +VNKL+
Sbjct: 606 KQVENKNKYIEELQQENKALKKKGTAESKQ----LNVYEIKVNKLE 647
Score = 46.2 bits (108), Expect = 3e-05
Identities = 53/271 (19%), Positives = 119/271 (43%), Gaps = 32/271 (11%)
Query: 14 KEDNQDTSSLA-------DAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAIS 66
KE Q+TS + + + KQ++ +IE ++ L+NEL + +E+
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREEL---K 584
Query: 67 AETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYN 126
+ E + ++ + + N + ++ I+ L EN LK + + IK N
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN 644
Query: 127 AYYAKIKAHKNSLGEVESKWSFMTELHEKR-------DFVKKLKTMKEE---LMQDLQNP 176
++++ K GE+ ++ E+ +K+ + V+K K + +E L +++
Sbjct: 645 KLELELESAKQKFGEITD--TYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKR 702
Query: 177 GGNRITQ---VQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDA- 232
++I + + E + DKII ++S + E+E+ + LR +E++ A
Sbjct: 703 CQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSS---LRASLEIELSNLKAE 759
Query: 233 ---ILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
+ K+L + + + +R+ + N L++
Sbjct: 760 LLSVKKQLEIEREEKEKLKREAKENTATLKE 790
Score = 42.7 bits (99), Expect = 3e-04
Identities = 58/257 (22%), Positives = 110/257 (42%), Gaps = 31/257 (12%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
+ + Q D ++ + + Q ++SE+E+ K+ N + EL EL+K + E E
Sbjct: 392 RTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLG-------EKE 444
Query: 74 RQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNA---YYA 130
+Y EN + + + ++K E + L E D E + YY+
Sbjct: 445 TLLY------ENKQF--EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYS 496
Query: 131 KIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITN 190
K K+ E+E++ TEL KL +EL Q+ + Q QEDI N
Sbjct: 497 K--EVKDLKTELENEKLKNTEL---TSHCNKLSLENKELTQETSDMTLELKNQ-QEDINN 550
Query: 191 LKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQ 250
K + +E ++++ +E ++T +LR E+E + + C+++K + N
Sbjct: 551 NKKQ----EERMLKQ---IENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNN 603
Query: 251 WQWNIQQLEKTAAELRK 267
+ ++ K EL++
Sbjct: 604 LRKQVENKNKYIEELQQ 620
Score = 38.5 bits (88), Expect = 0.006
Identities = 48/257 (18%), Positives = 112/257 (43%), Gaps = 20/257 (7%)
Query: 21 SSLADAVEKVAKQQQS-------QASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
S L EK+ K + S + S++++N+K++ + + EL+ +S + +E
Sbjct: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGI 166
Query: 74 RQIYQQDSAIEN--TKLHCDSLETQIKSLHSENVKLKFDIETAQE---DFEEHMIKYNAY 128
++ +D EN T+ C+ L+ + K +++ E ++ D ++ K
Sbjct: 167 QE--NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITA 224
Query: 129 YAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDI 188
+ +++ + S+ +L E + ++ L+ ++ + D + + Q+ E
Sbjct: 225 FEELRVQAEN-----SRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 189 TNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNR 248
+KD ++ES + E+ K E L++ IE QH L+ + + + S +
Sbjct: 280 NKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH-HLTKELEDIKVSLQRSVSTQ 338
Query: 249 RQWQWNIQQLEKTAAEL 265
+ + ++Q KT +L
Sbjct: 339 KALEEDLQIATKTICQL 355
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 53.5 bits (127), Expect = 2e-07
Identities = 58/273 (21%), Positives = 119/273 (43%), Gaps = 27/273 (9%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
K+RK + E +D L + KV K++ + ++++ + + L + +L KE A
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA 1004
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHS---ENVKLKFDIETAQEDFEEH 121
+ ++T + ++ + LE Q+ L + KL+ D+E A+ E
Sbjct: 1005 LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-- 1062
Query: 122 MIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRI 181
+K + S+ ++E++ + E +K++F ++ ++ ++ +D Q G
Sbjct: 1063 --------GDLKLAQESIMDIENEKQQLDEKLKKKEF--EISNLQSKI-EDEQALG---- 1107
Query: 182 TQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQV 241
Q+Q+ I L+ +I ++E I + + +K L +E+E +R + Q+
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 242 N-------KLQSNRRQWQWNIQQLEKTAAELRK 267
+ Q RR + Q E TAA LRK
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Score = 44.7 bits (104), Expect = 9e-05
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 24/233 (10%)
Query: 42 EKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLH 101
E K+ L ++ + L+ EI + A ++TER + + + L TQ SL
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 102 SENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKK 161
+ KL+ DI Q + E+ I A A+ KA K + EL +++D
Sbjct: 1731 NTKKKLETDISQMQGEMED--ILQEARNAEEKAKK----AITDAAMMAEELKKEQDTSAH 1784
Query: 162 LKTMK---EELMQDLQ-----------NPGGNRITQVQEDITNLKDKIITVKESIIEKTC 207
L+ MK E+ ++DLQ G +I +++ + L+ ++ ES ++
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV----ESEQKRNA 1840
Query: 208 FLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
+ + HE+ KE+ Q + + RL V+KLQ+ + ++ ++ E+
Sbjct: 1841 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1893
Score = 43.1 bits (100), Expect = 3e-04
Identities = 51/269 (18%), Positives = 109/269 (40%), Gaps = 37/269 (13%)
Query: 32 KQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCD 91
K+ + E +K K L + + ELE+++ + E + + Q+ + + + + CD
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 92 -------SLETQIK----------SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKA 134
LE +IK +++E K +E + ++ + AK++
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 135 HKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDK 194
K++ E+K +TE D T +++ +Q+ + + ++ + L
Sbjct: 973 EKHA---TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 195 IITVKESIIEKTCFLEEEKKTHEKLRK-----------------EIEVQHKRYDAILKRL 237
I +++ + + LE+EKK L + +IE + ++ D LK+
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 238 HCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
+++ LQS Q QL+K EL+
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQ 1118
Score = 42.4 bits (98), Expect = 4e-04
Identities = 50/269 (18%), Positives = 113/269 (42%), Gaps = 33/269 (12%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-------KNKKVLFNLKNELHELEKEIAAISAETK 70
Q T L +A +K+A++ Q+ +E +K L+NE+ +L ++ +A
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 71 ETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYA 130
+++ D + K C+ ++++ E L ++ + +EE + +
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK- 1505
Query: 131 KIKAHKNSLGEVESKWSFMTE----LHEKRDFVKKLKTMKEELMQDLQNPGGN------R 180
+ +KN E+ + E +HE K+++ K EL L+ + +
Sbjct: 1506 --RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH----EKLRKEIEVQ-HKRYDAILK 235
I ++Q ++ +K + V I EK +++ K+ H E ++ ++ + R DAI
Sbjct: 1564 ILRIQLELNQVKSE---VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 236 RLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
+ K++ + + + + + AAE
Sbjct: 1621 K-----KKMEGDLNEMEIQLNHANRMAAE 1644
Score = 39.7 bits (91), Expect = 0.003
Identities = 57/266 (21%), Positives = 119/266 (44%), Gaps = 42/266 (15%)
Query: 2 SDNKERKSQGFP--KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELE 59
+ KE +S G K N SL D +E + ++ ++ EI + + +HELE
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESL-DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE 1533
Query: 60 KEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQED 117
K K+ E++ + +A+E + + E +I + E VK + D + A++D
Sbjct: 1534 K-------IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 118 FEEHMIKYNAYYAKIKAHKNSLGEVESKWSFM-TELHEKRDFVKKLKTMKEELMQ-DLQN 175
E +K +N + VES S + E+ + D ++ K M+ +L + ++Q
Sbjct: 1587 EEIDQLK-----------RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL 1635
Query: 176 PGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILK 235
NR+ E + N ++ +K++ I L++ ++ E L++++ + +R
Sbjct: 1636 NHANRM--AAEALRNYRNTQGILKDTQIH----LDDALRSQEDLKEQLAMVERR------ 1683
Query: 236 RLHCQVNKLQSNRRQWQWNIQQLEKT 261
N LQ+ + + ++Q E++
Sbjct: 1684 -----ANLLQAEIEELRATLEQTERS 1704
Score = 37.4 bits (85), Expect = 0.014
Identities = 45/254 (17%), Positives = 102/254 (40%), Gaps = 27/254 (10%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIY 77
++ +L +A ++ Q++ ++ K L+ ++ +LE + + ER
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 78 QQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKN 137
+ + ++ + +E + + L + K +F+I Q E+ KIK +
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 138 SLGEVESKWSFMTELHEKRDFVKK-LKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII 196
+ E+E + K + + L EE+ + L+ GG Q++ +
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN--------- 1170
Query: 197 TVKESIIEKTCFLEEEKKTHEKLRKEIE---VQHKRYDAILKRLHC-QVNKLQSNRRQWQ 252
++ + +K+R+++E +QH+ A L++ H V +L Q
Sbjct: 1171 -------------KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 253 WNIQQLEKTAAELR 266
Q+LEK +E++
Sbjct: 1218 RVKQKLEKEKSEMK 1231
Score = 33.5 bits (75), Expect = 0.20
Identities = 49/273 (17%), Positives = 111/273 (40%), Gaps = 26/273 (9%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
NK+R+++ F K + A ++ A + + + + NL+ +LEKE +
Sbjct: 1170 NKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 64 AISAETKETERQIYQQDSAIENTKLHCDSLETQ---IKSLHSENVKLKFD-------IET 113
+ E + + A N + C +LE Q +KS E +L D ++T
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKNSLGE--VESKWSFMTELHEKRDFVKKLKTMKE--EL 169
+F + + A +++ K + + E K E+ K L++ + +L
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 170 MQDLQNPGGNRITQVQEDITNLKDKI----ITVKESIIEKTCFLEEEKKTHEKLRKEIEV 225
+++ ++Q ++ ++ + I++T LEE KK KL + ++
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---KLAQRLQA 1405
Query: 226 QHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQL 258
+ +A+ + + L+ +++ Q ++ L
Sbjct: 1406 AEEHVEAV----NAKCASLEKTKQRLQNEVEDL 1434
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 53.5 bits (127), Expect = 2e-07
Identities = 58/273 (21%), Positives = 119/273 (43%), Gaps = 27/273 (9%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
K+RK + E +D L + KV K++ + ++++ + + L + +L KE A
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA 1004
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHS---ENVKLKFDIETAQEDFEEH 121
+ ++T + ++ + LE Q+ L + KL+ D+E A+ E
Sbjct: 1005 LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-- 1062
Query: 122 MIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRI 181
+K + S+ ++E++ + E +K++F ++ ++ ++ +D Q G
Sbjct: 1063 --------GDLKLAQESIMDIENEKQQLDEKLKKKEF--EISNLQSKI-EDEQALG---- 1107
Query: 182 TQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQV 241
Q+Q+ I L+ +I ++E I + + +K L +E+E +R + Q+
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 242 N-------KLQSNRRQWQWNIQQLEKTAAELRK 267
+ Q RR + Q E TAA LRK
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Score = 44.7 bits (104), Expect = 9e-05
Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 24/233 (10%)
Query: 42 EKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLH 101
E K+ L ++ + L+ EI + A ++TER + + + L TQ SL
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 102 SENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKK 161
+ KL+ DI Q + E+ I A A+ KA K + EL +++D
Sbjct: 1731 NTKKKLETDISQMQGEMED--ILQEARNAEEKAKK----AITDAAMMAEELKKEQDTSAH 1784
Query: 162 LKTMK---EELMQDLQ-----------NPGGNRITQVQEDITNLKDKIITVKESIIEKTC 207
L+ MK E+ ++DLQ G +I +++ + L+ ++ ES ++
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV----ESEQKRNA 1840
Query: 208 FLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
+ + HE+ KE+ Q + + RL V+KLQ+ + ++ ++ E+
Sbjct: 1841 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1893
Score = 43.1 bits (100), Expect = 3e-04
Identities = 51/269 (18%), Positives = 109/269 (40%), Gaps = 37/269 (13%)
Query: 32 KQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCD 91
K+ + E +K K L + + ELE+++ + E + + Q+ + + + + CD
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 92 -------SLETQIK----------SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKA 134
LE +IK +++E K +E + ++ + AK++
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 135 HKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDK 194
K++ E+K +TE D T +++ +Q+ + + ++ + L
Sbjct: 973 EKHA---TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 195 IITVKESIIEKTCFLEEEKKTHEKLRK-----------------EIEVQHKRYDAILKRL 237
I +++ + + LE+EKK L + +IE + ++ D LK+
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 238 HCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
+++ LQS Q QL+K EL+
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQ 1118
Score = 42.4 bits (98), Expect = 4e-04
Identities = 50/269 (18%), Positives = 113/269 (42%), Gaps = 33/269 (12%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-------KNKKVLFNLKNELHELEKEIAAISAETK 70
Q T L +A +K+A++ Q+ +E +K L+NE+ +L ++ +A
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 71 ETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYA 130
+++ D + K C+ ++++ E L ++ + +EE + +
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK- 1505
Query: 131 KIKAHKNSLGEVESKWSFMTE----LHEKRDFVKKLKTMKEELMQDLQNPGGN------R 180
+ +KN E+ + E +HE K+++ K EL L+ + +
Sbjct: 1506 --RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH----EKLRKEIEVQ-HKRYDAILK 235
I ++Q ++ +K + V I EK +++ K+ H E ++ ++ + R DAI
Sbjct: 1564 ILRIQLELNQVKSE---VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 236 RLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
+ K++ + + + + + AAE
Sbjct: 1621 K-----KKMEGDLNEMEIQLNHANRMAAE 1644
Score = 39.7 bits (91), Expect = 0.003
Identities = 57/266 (21%), Positives = 119/266 (44%), Gaps = 42/266 (15%)
Query: 2 SDNKERKSQGFP--KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELE 59
+ KE +S G K N SL D +E + ++ ++ EI + + +HELE
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESL-DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE 1533
Query: 60 KEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQED 117
K K+ E++ + +A+E + + E +I + E VK + D + A++D
Sbjct: 1534 K-------IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 118 FEEHMIKYNAYYAKIKAHKNSLGEVESKWSFM-TELHEKRDFVKKLKTMKEELMQ-DLQN 175
E +K +N + VES S + E+ + D ++ K M+ +L + ++Q
Sbjct: 1587 EEIDQLK-----------RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL 1635
Query: 176 PGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILK 235
NR+ E + N ++ +K++ I L++ ++ E L++++ + +R
Sbjct: 1636 NHANRM--AAEALRNYRNTQGILKDTQIH----LDDALRSQEDLKEQLAMVERR------ 1683
Query: 236 RLHCQVNKLQSNRRQWQWNIQQLEKT 261
N LQ+ + + ++Q E++
Sbjct: 1684 -----ANLLQAEIEELRATLEQTERS 1704
Score = 37.4 bits (85), Expect = 0.014
Identities = 45/254 (17%), Positives = 102/254 (40%), Gaps = 27/254 (10%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIY 77
++ +L +A ++ Q++ ++ K L+ ++ +LE + + ER
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 78 QQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKN 137
+ + ++ + +E + + L + K +F+I Q E+ KIK +
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 138 SLGEVESKWSFMTELHEKRDFVKK-LKTMKEELMQDLQNPGGNRITQVQEDITNLKDKII 196
+ E+E + K + + L EE+ + L+ GG Q++ +
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN--------- 1170
Query: 197 TVKESIIEKTCFLEEEKKTHEKLRKEIE---VQHKRYDAILKRLHC-QVNKLQSNRRQWQ 252
++ + +K+R+++E +QH+ A L++ H V +L Q
Sbjct: 1171 -------------KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 253 WNIQQLEKTAAELR 266
Q+LEK +E++
Sbjct: 1218 RVKQKLEKEKSEMK 1231
Score = 33.5 bits (75), Expect = 0.20
Identities = 49/273 (17%), Positives = 111/273 (40%), Gaps = 26/273 (9%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
NK+R+++ F K + A ++ A + + + + NL+ +LEKE +
Sbjct: 1170 NKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 64 AISAETKETERQIYQQDSAIENTKLHCDSLETQ---IKSLHSENVKLKFD-------IET 113
+ E + + A N + C +LE Q +KS E +L D ++T
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKNSLGE--VESKWSFMTELHEKRDFVKKLKTMKE--EL 169
+F + + A +++ K + + E K E+ K L++ + +L
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 170 MQDLQNPGGNRITQVQEDITNLKDKI----ITVKESIIEKTCFLEEEKKTHEKLRKEIEV 225
+++ ++Q ++ ++ + I++T LEE KK KL + ++
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---KLAQRLQA 1405
Query: 226 QHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQL 258
+ +A+ + + L+ +++ Q ++ L
Sbjct: 1406 AEEHVEAV----NAKCASLEKTKQRLQNEVEDL 1434
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 53.1 bits (126), Expect = 2e-07
Identities = 64/264 (24%), Positives = 111/264 (42%), Gaps = 29/264 (10%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
+ED++ T LA+A V + S +E+ +K L+ E+H E A SA+TK +
Sbjct: 327 EEDHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHR-RFENAPDSAKTKALQ 381
Query: 74 RQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIK 133
I +DS I S+E ++ L E LK + + E+ EE M + Y + K
Sbjct: 382 TVIEMKDSKIS-------SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 134 AHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKD 193
KN +G+V+ EL K + L+T E L + I ++E +T +
Sbjct: 435 FMKNKIGQVKQ------ELSRKDTELLALQTKLETLTNQFSD-SKQHIEVLKESLTAKEQ 487
Query: 194 KIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH----------CQVNK 243
+ ++ + LEE++ K K+I+ + +H +VN
Sbjct: 488 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 547
Query: 244 LQSNRRQWQWNIQQLEKTAAELRK 267
LQ Q ++ EK + L++
Sbjct: 548 LQKKIENLQEQLRDKEKQMSSLKE 571
Score = 47.0 bits (110), Expect = 2e-05
Identities = 50/285 (17%), Positives = 123/285 (43%), Gaps = 33/285 (11%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK 60
M D+K + ++ ++ L ++++ + ++E + +KN++ ++++
Sbjct: 386 MKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQ 445
Query: 61 EIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEE 120
E++ E + ++ + ++K H + L+ + + L+ +++ + EE
Sbjct: 446 ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE 505
Query: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFV-----------KKLKTMKEEL 169
N K K E K + E+H+ +D + KK++ ++E+L
Sbjct: 506 KETMLN------KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL 559
Query: 170 MQDLQNPGG--NRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLR------- 220
+ R+ +Q D TN + T++E++ EK ++T E+L+
Sbjct: 560 RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEK-------ERTIERLKEQRDRDE 612
Query: 221 KEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
+E + + Y LK L +V+ LQ + + + ++ L++ A+ L
Sbjct: 613 REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL 657
Score = 44.3 bits (103), Expect = 1e-04
Identities = 58/303 (19%), Positives = 126/303 (41%), Gaps = 46/303 (15%)
Query: 1 MSDNKERKSQGFPKEDNQDTS------SLADAVEKVAKQQQSQASEIEKNKKVLFNLKNE 54
MS KER N DT+ +LA+ + + ++ + + + ++ + N K +
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 625
Query: 55 LHELEKEIAAISAETKETERQIY--------------QQDS-------AIENTKLHCDSL 93
L +L+++++ + + E E + ++DS A+E K C +
Sbjct: 626 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 685
Query: 94 ETQIKSLHSENVKLKFDIETAQ--EDFEEHMIKYNAYYAKIKAHKNSLGEV--------E 143
E+Q+K H ++ + E + + E + +Y +K +A + L E+
Sbjct: 686 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 745
Query: 144 SKWSFMTELHEK-RDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESI 202
K + EL + +D KK+ +K + Q + + + + NL D +++S+
Sbjct: 746 DKDKKIAELERQVKDQNKKVANLKHK-EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
Query: 203 IEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTA 262
+K +EE E LR+ +++ +R + + + N +Q + + +EK
Sbjct: 805 RKKDDRIEE---LEEALRESVQITAEREMVLAQEESARTNA----EKQVEELLMAMEKVK 857
Query: 263 AEL 265
EL
Sbjct: 858 QEL 860
Score = 29.6 bits (65), Expect = 3.0
Identities = 33/168 (19%), Positives = 72/168 (42%), Gaps = 10/168 (5%)
Query: 93 LETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTEL 152
L+TQ+K + EN L+ D+E + M +++ + +L + E+ S +T
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEA--SKITIW 211
Query: 153 HEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEE 212
E+ V++ + +Q LQ+ ++Q D+ L + S + C E
Sbjct: 212 KEQYRVVQEENQHMQMTIQALQDE-----LRIQRDLNQLFQQ---DSSSRTGEPCVAELT 263
Query: 213 KKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
++ ++L E E Q K + K L ++++ ++ + ++K
Sbjct: 264 EENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK 311
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 52.8 bits (125), Expect = 3e-07
Identities = 63/311 (20%), Positives = 130/311 (41%), Gaps = 54/311 (17%)
Query: 6 ERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKV------LFNLKNELHELE 59
ERK + P+E ++ S + ++ QQ + EK +++ + L+ EL +
Sbjct: 147 ERKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHIN 206
Query: 60 KEIAAISAETKETERQIYQQDSAIENTK-------------LH-----CDSLETQIKS-- 99
+ + + ++ Q S+ E K LH C+S E +++
Sbjct: 207 QSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYER 266
Query: 100 ------------LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWS 147
L EN+K+K +++ AQ+ + ++ A+ K + + E+E
Sbjct: 267 GQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELE---- 322
Query: 148 FMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTC 207
E+ + +K ++E+L+Q+ +++ +E I +L+ K+ + + TC
Sbjct: 323 --LEVLKHTQSIKSQNNLQEKLVQE-----KSKVADAEEKILDLQRKLEHAHKVCLTDTC 375
Query: 208 FLEE---EKKTHEKLRKEIEVQHKRYDAILKR--LHCQVNKLQSNRRQWQWNIQQLEKTA 262
E+ E+K E + E +V+ + + KR L+ V++L R Q LE T
Sbjct: 376 ISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTC 435
Query: 263 AELRKCIGMQE 273
++ + I QE
Sbjct: 436 SQQQSRIQQQE 446
Score = 36.6 bits (83), Expect = 0.024
Identities = 50/269 (18%), Positives = 108/269 (40%), Gaps = 26/269 (9%)
Query: 1 MSDNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEK 60
MS K + ++ + LA ++ K + ++ E++K+K L L NE+H L
Sbjct: 1 MSQEKNEMFESEWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPG 60
Query: 61 EIAA----------ISAETKETERQIY---QQDSAIENTKL-------HCDSLETQIKSL 100
E + + E E E ++ Q+ + + + L + + E K
Sbjct: 61 ESESKDHFLIACDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDP 120
Query: 101 HSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVK 160
S L+ +I++ +E+ EE K + K E + SF E +K + +
Sbjct: 121 ESNEPILETEIQSRKEETEELCPKLGE-----RKQKEIPEESVKEGSFPRE-GQKEEGSQ 174
Query: 161 KLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLR 220
+ + MK+E + I +++E+++++ ++ + S + + EKL+
Sbjct: 175 QNRDMKDEEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLK 234
Query: 221 KEIEVQHKRYDAILKRLHCQVNKLQSNRR 249
+ + ++ L RL N ++ R
Sbjct: 235 YNQQGEVQQLHQNLHRLQILCNSAENELR 263
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 52.8 bits (125), Expect = 3e-07
Identities = 67/289 (23%), Positives = 123/289 (42%), Gaps = 41/289 (14%)
Query: 10 QGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAET 69
Q KE Q E+ +++++ + + +K +L+ E LEK++ + E
Sbjct: 284 QQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKEL 343
Query: 70 KETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIK----Y 125
++ +I Q E +LH ET+ E +L +I+ +ED H+IK
Sbjct: 344 EKNTNKIKQLSQ--EKGRLH-QLYETK----EGETTRLIREIDKLKEDINSHVIKVKWAQ 396
Query: 126 NAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKK-----LKTMKE-------ELMQDL 173
N A++ +HK + +++ + +T+ E+ D ++K +KT +E EL L
Sbjct: 397 NKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKL 456
Query: 174 QNPGGNRITQVQE----------DITNLKDKIITVKESIIE-------KTCFLEEEKKTH 216
+ G Q+QE I L+D T KE + E C +E +T
Sbjct: 457 RVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTE 516
Query: 217 EKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAEL 265
++L K E+ + R A ++ L +V + Q Q Q++E E+
Sbjct: 517 DELSKYKEIIN-RQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEV 564
Score = 41.2 bits (95), Expect = 0.001
Identities = 58/287 (20%), Positives = 120/287 (41%), Gaps = 35/287 (12%)
Query: 3 DNKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEI 62
+ KE ++ +E ++ + V KV Q +E++ +K+ LK +L +
Sbjct: 365 ETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAK 424
Query: 63 AAISAETKETERQI--YQQDSAIENTKLHCD------SLETQIKS----LHSENVKLKFD 110
K + I YQ+ I++ +L LE Q++ L + K+K +
Sbjct: 425 EEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK-E 483
Query: 111 IETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELM 170
+E + F+E M + K+K ++ E EL + ++ + + K + L+
Sbjct: 484 LEDLKRTFKEGMDELRTLRTKVKCLEDERLRTED------ELSKYKEIINRQKAEIQNLL 537
Query: 171 QDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRY 230
++ Q+QE + K +I +KE + + + L+K+IE KR
Sbjct: 538 DKVKTAD-----QLQEQLQRGKQEIENLKEEVESLNSLIND-------LQKDIEGSRKRE 585
Query: 231 DAIL---KRLHCQVNKLQSNRRQWQWNIQQLEKTAAELR-KCIGMQE 273
+L +RL + +LQS Q ++ + ++L+ +C M++
Sbjct: 586 SELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQ 632
Score = 37.7 bits (86), Expect = 0.011
Identities = 40/180 (22%), Positives = 80/180 (44%), Gaps = 16/180 (8%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
K + Q+ +++ +Q Q EIE K+ + +L + +++L+K+I + +E+E
Sbjct: 530 KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIE--GSRKRESE 587
Query: 74 RQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIK 133
++ + +N +L +S SL S+ K+ Q E+ +K + +
Sbjct: 588 LLLFTERLTSKNAQLQSES-----NSLQSQFDKVSCSESQLQSQCEQ--MKQTNINLESR 640
Query: 134 AHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKD 193
K E + EL ++ VK L T EEL +L +TQ ++ +++KD
Sbjct: 641 LLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL-------VTQRRKHASSIKD 693
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 52.8 bits (125), Expect = 3e-07
Identities = 56/255 (21%), Positives = 118/255 (46%), Gaps = 35/255 (13%)
Query: 29 KVAKQQQSQASEIEKNKKVLFNLKNELHELE-------KEIAAISAETKETERQIYQQDS 81
+VA Q+ ++S + +N+ VL N+ +E + + + ++ + + ++ ++
Sbjct: 205 QVAALQEEKSSLLAENQ-VLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEA 263
Query: 82 AIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGE 141
A ++ ++ C+ LE +I L +N +L + AQ +E + ++ K G+
Sbjct: 264 AKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLE----GQ 319
Query: 142 VESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNL---KDKIITV 198
VES + +L + D +++K ++E+ +QN ++E++ + ++ T
Sbjct: 320 VES---YKKKLEDLGDLRRQVKLLEEKNTMYMQNT-----VSLEEELRKANAARSQLETY 371
Query: 199 KESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQL 258
K ++E L EE K +KL D KRL +V+ LQ + + + L
Sbjct: 372 KRQVVELQNRLSEESKKADKL-----------DFEYKRLKEKVDSLQKEKDRLRTERDSL 420
Query: 259 EKTAAELRKCIGMQE 273
++T ELR C+ QE
Sbjct: 421 KETIEELR-CVQAQE 434
Score = 34.3 bits (77), Expect = 0.12
Identities = 57/269 (21%), Positives = 109/269 (40%), Gaps = 41/269 (15%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIY 77
Q+T SL + + K + S++E K+ + L+N L E K+ + E K + ++
Sbjct: 349 QNTVSLEEELRKA----NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
Query: 78 QQDSAIENTKLHCDSLETQIKSLH------------------SENVKLKFDIETAQEDFE 119
+ + DSL+ I+ L S+ E +
Sbjct: 405 SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIR 464
Query: 120 EHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVK-KLKTMKEELMQDLQNPGG 178
E +I+ +K N G K + + L + + K +L+T + Q L
Sbjct: 465 EKLIRLQHENKMLKL--NQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ- 521
Query: 179 NRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH 238
+QV+E +L+D+ ++S++ K E +K HE E+Q KR AI++ L
Sbjct: 522 ---SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHE---ANNELQKKR--AIIEDLE 573
Query: 239 -------CQVNKLQSNRRQWQWNIQQLEK 260
++ +LQ R+ + ++Q+E+
Sbjct: 574 PRFNNSSLKIEELQEALRKKEEEMKQMEE 602
>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
Length = 761
Score = 52.0 bits (123), Expect = 6e-07
Identities = 67/259 (25%), Positives = 112/259 (43%), Gaps = 24/259 (9%)
Query: 21 SSLADA-VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQ 79
SSL DA EK A + QS + EK L ELE EI + E KE + + +Q
Sbjct: 110 SSLKDASFEKEATEAQSLEATCEK-------LNRSNSELEDEILCLEKELKEEKSKHSEQ 162
Query: 80 DSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQEDFEEHMIK--YNAYYAKIKAH 135
D + + SLE + KSL S+ K+ F I E+ + IK N ++
Sbjct: 163 DELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQ 222
Query: 136 KNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKI 195
K L E E ++EL++++ + K E+++ D + + I + E + +KD
Sbjct: 223 KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE----SHIKTLTERLLKMKDWA 278
Query: 196 ITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH-----CQVNKLQSNRRQ 250
+ E I + LE E + + ++ K A+ K +H + L+ R Q
Sbjct: 279 AMLGEDITDDD-NLELEMNSESENGAYLDNPPK--GALKKLIHAAKLNASLKTLEGERNQ 335
Query: 251 WQWNIQQLEKTAAELRKCI 269
+ +++KT EL + I
Sbjct: 336 IYIQLSEVDKTKEELTEHI 354
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 24/136 (17%)
Query: 66 SAETKETER-QIYQQDSAIENTKL----HCDSLETQIKSLHSENV-------KLKFDIET 113
S +T E ER QIY Q S ++ TK H +L+T+ SL SEN KL+ ++
Sbjct: 325 SLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKV 384
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKN-------SLGEVESKWSFMTELHEKRDFVKKLKTMK 166
E ++E+ +K + K+ +N L +V+ K S TE E + K+ K ++
Sbjct: 385 MTELYQENEMK---LHRKLTVEENYRLEKEEKLSKVDEKISHATE--ELETYRKRAKDLE 439
Query: 167 EELMQDLQNPGGNRIT 182
EEL + + + G I+
Sbjct: 440 EELERTIHSYQGQIIS 455
>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
Length = 804
Score = 52.0 bits (123), Expect = 6e-07
Identities = 67/259 (25%), Positives = 112/259 (43%), Gaps = 24/259 (9%)
Query: 21 SSLADA-VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQ 79
SSL DA EK A + QS + EK L ELE EI + E KE + + +Q
Sbjct: 110 SSLKDASFEKEATEAQSLEATCEK-------LNRSNSELEDEILCLEKELKEEKSKHSEQ 162
Query: 80 DSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQEDFEEHMIK--YNAYYAKIKAH 135
D + + SLE + KSL S+ K+ F I E+ + IK N ++
Sbjct: 163 DELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQ 222
Query: 136 KNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKI 195
K L E E ++EL++++ + K E+++ D + + I + E + +KD
Sbjct: 223 KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE----SHIKTLTERLLKMKDWA 278
Query: 196 ITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH-----CQVNKLQSNRRQ 250
+ E I + LE E + + ++ K A+ K +H + L+ R Q
Sbjct: 279 AMLGEDITDDD-NLELEMNSESENGAYLDNPPK--GALKKLIHAAKLNASLKTLEGERNQ 335
Query: 251 WQWNIQQLEKTAAELRKCI 269
+ +++KT EL + I
Sbjct: 336 IYIQLSEVDKTKEELTEHI 354
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 24/136 (17%)
Query: 66 SAETKETER-QIYQQDSAIENTKL----HCDSLETQIKSLHSENV-------KLKFDIET 113
S +T E ER QIY Q S ++ TK H +L+T+ SL SEN KL+ ++
Sbjct: 325 SLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKV 384
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKN-------SLGEVESKWSFMTELHEKRDFVKKLKTMK 166
E ++E+ +K + K+ +N L +V+ K S TE E + K+ K ++
Sbjct: 385 MTELYQENEMK---LHRKLTVEENYRLEKEEKLSKVDEKISHATE--ELETYRKRAKDLE 439
Query: 167 EELMQDLQNPGGNRIT 182
EEL + + + G I+
Sbjct: 440 EELERTIHSYQGQIIS 455
>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
Length = 775
Score = 52.0 bits (123), Expect = 6e-07
Identities = 67/259 (25%), Positives = 112/259 (43%), Gaps = 24/259 (9%)
Query: 21 SSLADA-VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQ 79
SSL DA EK A + QS + EK L ELE EI + E KE + + +Q
Sbjct: 81 SSLKDASFEKEATEAQSLEATCEK-------LNRSNSELEDEILCLEKELKEEKSKHSEQ 133
Query: 80 DSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQEDFEEHMIK--YNAYYAKIKAH 135
D + + SLE + KSL S+ K+ F I E+ + IK N ++
Sbjct: 134 DELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQ 193
Query: 136 KNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKI 195
K L E E ++EL++++ + K E+++ D + + I + E + +KD
Sbjct: 194 KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE----SHIKTLTERLLKMKDWA 249
Query: 196 ITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH-----CQVNKLQSNRRQ 250
+ E I + LE E + + ++ K A+ K +H + L+ R Q
Sbjct: 250 AMLGEDITDDD-NLELEMNSESENGAYLDNPPK--GALKKLIHAAKLNASLKTLEGERNQ 306
Query: 251 WQWNIQQLEKTAAELRKCI 269
+ +++KT EL + I
Sbjct: 307 IYIQLSEVDKTKEELTEHI 325
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 24/136 (17%)
Query: 66 SAETKETER-QIYQQDSAIENTKL----HCDSLETQIKSLHSENV-------KLKFDIET 113
S +T E ER QIY Q S ++ TK H +L+T+ SL SEN KL+ ++
Sbjct: 296 SLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKV 355
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKN-------SLGEVESKWSFMTELHEKRDFVKKLKTMK 166
E ++E+ +K + K+ +N L +V+ K S TE E + K+ K ++
Sbjct: 356 MTELYQENEMK---LHRKLTVEENYRLEKEEKLSKVDEKISHATE--ELETYRKRAKDLE 410
Query: 167 EELMQDLQNPGGNRIT 182
EEL + + + G I+
Sbjct: 411 EELERTIHSYQGQIIS 426
>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
Length = 792
Score = 52.0 bits (123), Expect = 6e-07
Identities = 67/259 (25%), Positives = 112/259 (43%), Gaps = 24/259 (9%)
Query: 21 SSLADA-VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQ 79
SSL DA EK A + QS + EK L ELE EI + E KE + + +Q
Sbjct: 98 SSLKDASFEKEATEAQSLEATCEK-------LNRSNSELEDEILCLEKELKEEKSKHSEQ 150
Query: 80 DSAIENTKLHCDSLETQIKSLHSE--NVKLKFDIETAQEDFEEHMIK--YNAYYAKIKAH 135
D + + SLE + KSL S+ K+ F I E+ + IK N ++
Sbjct: 151 DELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQ 210
Query: 136 KNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKI 195
K L E E ++EL++++ + K E+++ D + + I + E + +KD
Sbjct: 211 KQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKE----SHIKTLTERLLKMKDWA 266
Query: 196 ITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLH-----CQVNKLQSNRRQ 250
+ E I + LE E + + ++ K A+ K +H + L+ R Q
Sbjct: 267 AMLGEDITDDD-NLELEMNSESENGAYLDNPPK--GALKKLIHAAKLNASLKTLEGERNQ 323
Query: 251 WQWNIQQLEKTAAELRKCI 269
+ +++KT EL + I
Sbjct: 324 IYIQLSEVDKTKEELTEHI 342
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 24/136 (17%)
Query: 66 SAETKETER-QIYQQDSAIENTKL----HCDSLETQIKSLHSENV-------KLKFDIET 113
S +T E ER QIY Q S ++ TK H +L+T+ SL SEN KL+ ++
Sbjct: 313 SLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKV 372
Query: 114 AQEDFEEHMIKYNAYYAKIKAHKN-------SLGEVESKWSFMTELHEKRDFVKKLKTMK 166
E ++E+ +K + K+ +N L +V+ K S TE E + K+ K ++
Sbjct: 373 MTELYQENEMK---LHRKLTVEENYRLEKEEKLSKVDEKISHATE--ELETYRKRAKDLE 427
Query: 167 EELMQDLQNPGGNRIT 182
EEL + + + G I+
Sbjct: 428 EELERTIHSYQGQIIS 443
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 51.6 bits (122), Expect = 7e-07
Identities = 55/275 (20%), Positives = 117/275 (42%), Gaps = 20/275 (7%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
K R+S E Q+T + E Q Q + + + F K +L EKE+
Sbjct: 171 KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKL---EKELKQ 227
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIE-------TAQED 117
I A+ + +I ++ +K LE Q+K N + ++E Q++
Sbjct: 228 IQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQE 287
Query: 118 FEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPG 177
E+H + + + +N +E K + E+H+ R + KL ++E++ + L +
Sbjct: 288 NEQHSL-----VCEQLSQENQQKALELK-AKEEEVHQMRLDIGKLNKIREQIHKKLHHTE 341
Query: 178 GNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRL 237
+ +V++ LK++I+ ++ + E ++K ++L +E ++ +K +
Sbjct: 342 DQK-AEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNAT 400
Query: 238 HCQVNKL---QSNRRQWQWNIQQLEKTAAELRKCI 269
Q + + + +R + IQ + A + RK I
Sbjct: 401 QKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
Score = 44.3 bits (103), Expect = 1e-04
Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 46/298 (15%)
Query: 15 EDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETER 74
E +D S+ A+ K+ +QQ E E K L L+ + E + I AE ++ R
Sbjct: 528 ELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLR 587
Query: 75 QIYQQDSAIENTKLHCDSLETQIKSLHSENV-----------KLKFD---IETAQEDFEE 120
I + D K D + ++ L S+ V K+K + + + +
Sbjct: 588 IIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQ 647
Query: 121 HMIKYNAYYAKIKAHKNSLGEVESKWSFMTEL-----HEKRDFVKKLKTMKEELMQDLQN 175
+ +IK + G + + + EL H +R+ +K+ +T L ++L+N
Sbjct: 648 RLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKE-RTRCRALEEELEN 706
Query: 176 P-----------GGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLR---- 220
P ++ + I L+ ++I+ E ++EK L+E++K + +L+
Sbjct: 707 PLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLA 766
Query: 221 ----KEIEVQHKRYDAI-------LKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRK 267
E Q K Y LK L ++N + +++++ +++L L+K
Sbjct: 767 RQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKK 824
Score = 37.4 bits (85), Expect = 0.014
Identities = 28/145 (19%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 35 QSQASEIEKNKKVLFNLK-------NELHELEKEIAAISAETKETERQIYQQDSAIENTK 87
Q+ E +K +K++F+L+ N+ +L +++ + K E QI+ I ++
Sbjct: 422 QNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESE 481
Query: 88 LHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWS 147
+ + +++ S+ ++ AQ++ + K ++ K ++ +K S
Sbjct: 482 IKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE---DISAKES 538
Query: 148 FMTELH-EKRDFVKKLKTMKEELMQ 171
+ +LH E++ K+ +T+K EL +
Sbjct: 539 ALVKLHLEQQRIEKEKETLKAELQK 563
Score = 28.1 bits (61), Expect = 8.6
Identities = 45/222 (20%), Positives = 92/222 (41%), Gaps = 23/222 (10%)
Query: 28 EKVAKQQQSQASEIEKNKKVLFNLKNELHELEKE---IAAISAETKETERQIYQQDSAIE 84
+ V + +SQ ++ ++ ++L + E+ +L +E +A A +E ++ + +
Sbjct: 635 QSVLNKGESQYNQRLEDMRIL---RLEIKKLRREKGILARSMANVEELRQEFFHMQRELL 691
Query: 85 NTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVES 144
+ C +LE ++++ NV +E + + E + K + ++ + + E E
Sbjct: 692 KERTRCRALEEELEN--PLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKEL 749
Query: 145 KWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIE 204
L EK +LK + + PG Q++ L DK +K E
Sbjct: 750 L------LQEKEKLYMELKHVLA------RQPGPEAAEQLKLYRRTLHDKKQQLKVLSSE 797
Query: 205 KTCF---LEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNK 243
+ +E K EKL E++ K+Y A ++ Q NK
Sbjct: 798 LNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 50.8 bits (120), Expect = 1e-06
Identities = 60/254 (23%), Positives = 114/254 (44%), Gaps = 39/254 (15%)
Query: 16 DNQDTSSLAD--AVEKVAKQQQSQASE----IEKNKKVLFNLKNELHELEKEIAAISAET 69
DNQ LAD +E + ++ + +A E + + K ++ + +++ LE+ I +S
Sbjct: 729 DNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 788
Query: 70 KE-------TERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHM 122
K T+R + Q+ I + LETQ L ++N KL+ +E ++H
Sbjct: 789 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDH- 845
Query: 123 IKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRIT 182
+ KN L E+E++ ++ HE++ +LK EL LQ +++T
Sbjct: 846 -----------SDKNRLLELETRLREVSLEHEEQKL--ELKRQLTELQLSLQE-RESQLT 891
Query: 183 QVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDA------ILKR 236
+Q L+ ++ K + E T EEE + R EI+ +++DA ++
Sbjct: 892 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ---RKFDALRNSCTVITD 948
Query: 237 LHCQVNKLQSNRRQ 250
L Q+N+L + +
Sbjct: 949 LEEQLNQLTEDNAE 962
Score = 43.5 bits (101), Expect = 2e-04
Identities = 58/287 (20%), Positives = 123/287 (42%), Gaps = 53/287 (18%)
Query: 20 TSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA---------------- 63
+ S+ ++ AK + + K+K+ L + +++ H++E+E+
Sbjct: 431 SESVVSGLDSPAKTSSMEKKLLIKSKE-LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQK 489
Query: 64 AISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSE-------NVKLKFDIETAQE 116
+ + ET+R + +QD A T+ C SL+ ++ E ++L DI
Sbjct: 490 EVELKASETQRSLLEQDLATYITE--CSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 547
Query: 117 DFEEHMIKYNAYYAKIKAHKNSLGEVESKW--------SFMTELHEKR----DFVKKLKT 164
+E IK Y A+++ + + ++E + +EL E R +F +K
Sbjct: 548 KLQE--IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATE 605
Query: 165 MKEELM--QDLQNPGGNRITQVQE-------DITNLKDKIITVKESIIEKTCFLEEEKKT 215
+ +L+ +D P ++++ I L++K+ ++ E T L+ ++
Sbjct: 606 CQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 665
Query: 216 HEKLRKEIEVQHKRYDA---ILKRLHCQVNKLQSNRRQWQWNIQQLE 259
E+ +E+E R D+ I K+L + +L+ R+ Q + Q LE
Sbjct: 666 KERAERELEKLQNREDSSEGIRKKL-VEAEELEEKHREAQVSAQHLE 711
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 50.8 bits (120), Expect = 1e-06
Identities = 61/288 (21%), Positives = 126/288 (43%), Gaps = 27/288 (9%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
K+RK + E +D L + KV K++ + ++++ + + L + +L KE A
Sbjct: 943 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA 1002
Query: 65 ISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHS---ENVKLKFDIETAQEDFEEH 121
+ ++T + ++ + LE Q+ L + K++ D+E A+ E
Sbjct: 1003 LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD 1062
Query: 122 MIKYNAYYAKIKAHKNSLGEVESKWSF-MTELHEK-----------RDFVKKLKTMKEEL 169
+ I+ K L E K F M+ L K + +K+L+ EEL
Sbjct: 1063 LKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEEL 1122
Query: 170 MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIE----KTCFLEEEKKTH---EKLRKE 222
++++ +R + ++ ++L ++ + E + E + +E KK +K+R++
Sbjct: 1123 EEEIEAERASR-AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 223 IE---VQHKRYDAILKRLHC-QVNKLQSNRRQWQWNIQQLEKTAAELR 266
+E +QH+ A L++ H V +L Q Q+LEK +E++
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1229
Score = 46.2 bits (108), Expect = 3e-05
Identities = 52/269 (19%), Positives = 110/269 (40%), Gaps = 37/269 (13%)
Query: 32 KQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCD 91
K+ + E EK K+ L + + ELE+++ + E + + Q+ + ++ + + CD
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCD 910
Query: 92 -------SLETQIK----------SLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKA 134
LE +IK +++E K +E + ++ + AK++
Sbjct: 911 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 135 HKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDK 194
K++ E+K +TE D T +++ +Q+ + + ++ + L
Sbjct: 971 EKHA---TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 195 IITVKESIIEKTCFLEEEKKTHEKLRK-----------------EIEVQHKRYDAILKRL 237
I +++ + + LE+EKK L + +IE ++ D LK+
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 238 HCQVNKLQSNRRQWQWNIQQLEKTAAELR 266
+++ LQS Q QL+K EL+
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQ 1116
Score = 45.4 bits (106), Expect = 5e-05
Identities = 50/269 (18%), Positives = 113/269 (42%), Gaps = 33/269 (12%)
Query: 18 QDTSSLADAVEKVAKQQQSQASEIE-------KNKKVLFNLKNELHELEKEIAAISAETK 70
Q T L +A +K+A++ Q +E +K L+NE+ +L ++ +A
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444
Query: 71 ETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYA 130
+++ D + K C+ ++++ E+ L ++ + +EE + +
Sbjct: 1445 ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK- 1503
Query: 131 KIKAHKNSLGEVESKWSFMTE----LHEKRDFVKKLKTMKEELMQDLQNPGGN------R 180
+ +KN E+ + E +HE K+++ K EL L+ + +
Sbjct: 1504 --RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGK 1561
Query: 181 ITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH----EKLRKEIEVQ-HKRYDAILK 235
I ++Q ++ +K + V I EK +++ K+ H E ++ ++ + R DAI
Sbjct: 1562 ILRIQLELNQVKSE---VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 236 RLHCQVNKLQSNRRQWQWNIQQLEKTAAE 264
+ K++ + + + + + AAE
Sbjct: 1619 K-----KKMEGDLNEMEIQLNHANRMAAE 1642
Score = 45.4 bits (106), Expect = 5e-05
Identities = 55/233 (23%), Positives = 103/233 (44%), Gaps = 24/233 (10%)
Query: 42 EKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLH 101
E K+ L ++ + L+ EI + A ++TER + + + L TQ SL
Sbjct: 1669 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1728
Query: 102 SENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKK 161
+ KL+ DI Q + E+ I A A+ KA K + EL +++D
Sbjct: 1729 NTKKKLETDISQIQGEMED--IIQEARNAEEKAKK----AITDAAMMAEELKKEQDTSAH 1782
Query: 162 LKTMKEELMQ---DLQNP-----------GGNRITQVQEDITNLKDKIITVKESIIEKTC 207
L+ MK+ L Q DLQ+ G +I +++ + L+ ++ + ++ +E
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Query: 208 FLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEK 260
L + HE+ KE+ Q + + RL V+KLQ+ + ++ ++ E+
Sbjct: 1843 GLRK----HERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Score = 37.7 bits (86), Expect = 0.011
Identities = 61/298 (20%), Positives = 121/298 (40%), Gaps = 51/298 (17%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLF---NLKNELHELEKE 61
K + ++D + + + V Q + +EI + ++ +L+E+E +
Sbjct: 1573 KSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ 1632
Query: 62 IAAISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEH 121
+ + E R + +++T+LH D D +QED +E
Sbjct: 1633 LNHANRMAAEALRNYRNTQAILKDTQLHLD------------------DALRSQEDLKEQ 1674
Query: 122 MI----KYNAYYAKIKAHKNSLGEVE-SKWSFMTELHEKRDFVKKLKTM-------KEEL 169
+ + N A+I+ + +L + E S+ EL + + V+ L T K++L
Sbjct: 1675 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1734
Query: 170 MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH------EKLRKEI 223
D+ G +QE N ++K K++I + EE KK E+++K +
Sbjct: 1735 ETDISQIQGEMEDIIQE-ARNAEEK---AKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 224 E-----VQHKRYDA---ILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
E +QH+ +A LK Q+ KL++ R+ + ++ +K E K + E
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE 1848
Score = 32.7 bits (73), Expect = 0.35
Identities = 31/173 (17%), Positives = 78/173 (45%), Gaps = 14/173 (8%)
Query: 4 NKERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
NK+R+++ F K + A ++ A + + + + NL+ +LEKE +
Sbjct: 1168 NKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 64 AISAETKETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMI 123
+ E + + A N + C +LE Q+ +I+T +E+ + +
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS-----------EIKTKEEEQQRLIN 1275
Query: 124 KYNAYYAKIKAHKNSLG-EVESKWSFMTELHE-KRDFVKKLKTMKEELMQDLQ 174
A A+++ +++ K + +++L K+ F ++++ +K +L ++++
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328
Score = 32.0 bits (71), Expect = 0.59
Identities = 72/350 (20%), Positives = 133/350 (38%), Gaps = 93/350 (26%)
Query: 3 DNKERKSQGFPKE------------DNQDTSSLADA-VEKVAKQQQSQASEIEKNKKVLF 49
DN +R Q KE N +T S A +EK+ + + Q SEI+ ++
Sbjct: 1212 DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQ 1271
Query: 50 NLKNEL-------------------------HELEKEIAAISAETKETERQIYQQDSA-- 82
L N+L +L + A + + +E +RQ+ ++ A
Sbjct: 1272 RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKS 1331
Query: 83 -----IENTKLHCDSLETQIKSLHSENVKL-----KFDIETAQ----------------- 115
+++++ CD L Q + +L K + E AQ
Sbjct: 1332 ALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 116 ----------EDFEEHMIKYNAYYAKIKAHKNSLG--------EVESKWSFMTELHEK-R 156
+D EEH+ NA A ++ K L +VE + L +K R
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 157 DFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTH 216
+F K L K++ + + Q++ +L ++ +K + E LE K+ +
Sbjct: 1452 NFDKILAEWKQKCEET-----HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 217 EKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQ-QLEKTAAEL 265
+ L++EI ++ KR+H ++ K++ Q + +Q LE+ A L
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIH-ELEKIKKQVEQEKSELQAALEEAEASL 1555
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 50.8 bits (120), Expect = 1e-06
Identities = 63/290 (21%), Positives = 124/290 (42%), Gaps = 37/290 (12%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAE----- 68
K+ NQ L + E ++++ + +E+ K K +LF + E E+ KEI + E
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAEL-KQKILLFGCEKE--EMNKEITWLKEEGVKQD 1105
Query: 69 --TKETERQIYQQDSAI-----ENTKL--HCDSLETQIKSLHSENVKLKFDIETAQEDFE 119
E + Q+ Q+ + + + TKL H + LE + EN L+ + + E
Sbjct: 1106 TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
Query: 120 EHMIKYNAYYAKIK-----------AHKNSLGEVESKWSFMTELHEKRDF-----VKKLK 163
E K + +K+K +H+ S +E K +L E+ KK +
Sbjct: 1166 EDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE 1225
Query: 164 TMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEI 223
+ E +L N ++ + I++ + + VKE+++ KTC + E + +L +E
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 224 EVQHKRYDAILKRLHCQVNKLQSNRRQWQWNIQQLEKTAAELRKCIGMQE 273
+ + +L + N+++S + +I+ L L+K G Q+
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKA----DIESLVTEKEALQKEGGNQQ 1331
Score = 48.9 bits (115), Expect = 5e-06
Identities = 54/252 (21%), Positives = 115/252 (45%), Gaps = 22/252 (8%)
Query: 18 QDTSSLADAV--EKVAKQQQ-----SQASEIEKNKKVLFNL-KNELHELEKEIAAISAET 69
QD S D + EK++ +Q ++ SE +K + F +N + EL+ ++ S E
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474
Query: 70 KETERQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYY 129
E + QI ++ D L+ +++ S+ K + ++ET + +++ +
Sbjct: 1475 YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHI 1534
Query: 130 AKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDIT 189
+ SL EV ++ ++ E ++ V+KL+ Q+L NR+ + +E I
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDI-EHKELVQKLQHF-----QELGEEKDNRVKEAEEKIL 1588
Query: 190 NLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQ-VNKLQSNR 248
L++++ ++K LE +KK E + ++ + + A+ RL + KL +
Sbjct: 1589 TLENQVYSMKAE-------LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 249 RQWQWNIQQLEK 260
R+ + I ++K
Sbjct: 1642 RKAEQKIAAIKK 1653
Score = 48.1 bits (113), Expect = 8e-06
Identities = 63/285 (22%), Positives = 120/285 (42%), Gaps = 40/285 (14%)
Query: 5 KERKSQGFPKEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAA 64
K+ +QG + ++ S A A E++ K + E +K+ + ++ +EK
Sbjct: 392 KQMTTQGEELREQKEKSERA-AFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK---- 446
Query: 65 ISAETKETERQIYQQD------SAIENTKLHCDSLETQIKSLHSENV-----KLKFDIET 113
T E ER QQ+ ++ K + +++ LH + + +L ++T
Sbjct: 447 ----TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 114 AQEDFEEHMI----KYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEEL 169
+ +F+E M K + Y KI K E + S E E + K + T E
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEK------EQQESLALEELELQK--KAILTESENK 554
Query: 170 MQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKR 229
++DLQ T++ E ++L+ + K + LE EK H KEI V ++
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH---NKEITVMVEK 611
Query: 230 YDAILKRLHCQ-----VNKLQSNRRQWQWNIQQLEKTAAELRKCI 269
+ L+ L Q KLQ ++Q+Q +++L + + ++ +
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL 656
Score = 43.9 bits (102), Expect = 2e-04
Identities = 60/310 (19%), Positives = 130/310 (41%), Gaps = 49/310 (15%)
Query: 7 RKSQGFPKEDNQDTSSLADAVEKVA---KQQQSQASEIEKNKKVLFNLKNELHELEKEIA 63
+K Q F + + + + +A EK+ Q S +E+E KK L ++ + E+E+
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 64 AI--------SAETKETERQIYQQDSAI----------------ENTKLHCDSLETQIKS 99
A+ +A+ E +R+ Q+ +AI + T+ H L T+++
Sbjct: 1624 ALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE 1683
Query: 100 LHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEVESKWSFMTELHEKRDFV 159
E L+ +++ + E +I + AK A E +S+ EK +
Sbjct: 1684 REREVHILEEKLKSVESSQSETLIVPRS--AKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
Query: 160 KKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESIIEKTCFLEEEKKTHEKL 219
++ T KE+L+Q + ++ E ++++I ++ + ++ E++ L
Sbjct: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ----HEDQSMIGHL 1797
Query: 220 RKEIEVQHKRYDAIL----------------KRLHCQVNKLQSNRRQWQWNIQQLEKTAA 263
++E+E ++K+Y I+ + L + +Q ++ + Q LE+
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK 1857
Query: 264 ELRKCIGMQE 273
EL C+ Q+
Sbjct: 1858 ELDSCLVRQK 1867
Score = 43.5 bits (101), Expect = 2e-04
Identities = 57/256 (22%), Positives = 109/256 (42%), Gaps = 62/256 (24%)
Query: 28 EKVAKQQQ--SQASEIEKNKKV-----------LFNLKNELHELEKEIAAISAETKETER 74
EK A Q+Q + E+EK K + L + KN + +LE++ + AETK
Sbjct: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR--- 371
Query: 75 QIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKA 134
Q +E + L ++IK + ++ +L+ K K+
Sbjct: 372 ---QMHETLEMKEEEIAQLRSRIKQMTTQGEELR--------------------EQKEKS 408
Query: 135 HKNSLGEVESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDK 194
+ + E+E S + E R +KLK +E ++ ++ +Q++++ +K +
Sbjct: 409 ERAAFEELEKALSTAQKTEEAR---RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE 465
Query: 195 IITVKESIIEKTCFLEEEKKTHEK--LRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQWQ 252
++ V + E+ + + +K HEK RKE E+ KLQ+ R++Q
Sbjct: 466 VVDVMKKSSEEQ--IAKLQKLHEKELARKEQEL---------------TKKLQTREREFQ 508
Query: 253 WNIQ-QLEKTAAELRK 267
++ LEK+ +E K
Sbjct: 509 EQMKVALEKSQSEYLK 524
Score = 42.0 bits (97), Expect = 6e-04
Identities = 44/236 (18%), Positives = 99/236 (41%), Gaps = 17/236 (7%)
Query: 28 EKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAET---------KETERQIYQ 78
EK ++ + +E+E L + H+LE+E++ + +T K E++ +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 79 QDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNS 138
Q K H S++ K+L + +L+ ++ + +EH A IK +
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 139 LGEVESK----WSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDK 194
L + +K S+ + HE+ ++ ++ + DL+ QV E KD
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 195 IITVKESIIEKTCFLEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQVNKLQSNRRQ 250
+ I+ +++ +K + ++ ++++ + Y++ L+ NK Q +Q
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE----DGNKEQEQTKQ 904
Score = 37.0 bits (84), Expect = 0.018
Identities = 56/256 (21%), Positives = 101/256 (39%), Gaps = 39/256 (15%)
Query: 14 KEDNQDTSSLADAVEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETE 73
K D + + +A++K QQ ASE E + LK EL E + + E KE
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKES---CITQLKKELSENINAVTLMKEELKEK- 1365
Query: 74 RQIYQQDSAIENTKLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIK 133
K+ SL Q+ L NV+L+ I ++++ A I
Sbjct: 1366 -------------KVEISSLSKQLTDL---NVQLQNSISLSEKE------------AAIS 1397
Query: 134 AHKNSLGEVESKW-SFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLK 192
+ + E + + + +L K D + K K E + D N + Q T +
Sbjct: 1398 SLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQ 1457
Query: 193 DKIITVKESIIEKTCFLEEEKKTHEK---LRKEIEVQHKRYDAILKRLHCQVNKLQSNRR 249
+ TVKE I+ +E + E+ L++E++ Q+KR+D + + +K++
Sbjct: 1458 N---TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 250 QWQWNIQQLEKTAAEL 265
+ ++ EL
Sbjct: 1515 NLETELKSQTARIMEL 1530
>gi|221316642 nuclear distribution gene E homolog 1 [Homo sapiens]
Length = 335
Score = 50.4 bits (119), Expect = 2e-06
Identities = 46/207 (22%), Positives = 95/207 (45%), Gaps = 25/207 (12%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
+E K S+ E K + K ++E+ ++E E ++ Q
Sbjct: 1 MEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQ------- 53
Query: 87 KLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEV---- 142
+ET+ + L SEN +L+ ++ET +E FE ++++ Y +I A ++ L +
Sbjct: 54 ---LQQIETRNRDLLSENNRLRMELETIKEKFE---VQHSEGYRQISALEDDLAQTKAIK 107
Query: 143 ESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESI 202
+ ++ EL + D +++ K ++D + R+ Q E L+ + + KE++
Sbjct: 108 DQLQKYIRELEQANDDLERAKRATIMSLEDFE----QRLNQAIERNAFLESE-LDEKENL 162
Query: 203 IEKTCFLEEEKKTHEKLRKEIEVQHKR 229
+E L++E + LR+E+ VQ K+
Sbjct: 163 LESVQRLKDEAR---DLRQELAVQQKQ 186
>gi|8923110 nuclear distribution gene E homolog 1 [Homo sapiens]
Length = 335
Score = 50.4 bits (119), Expect = 2e-06
Identities = 46/207 (22%), Positives = 95/207 (45%), Gaps = 25/207 (12%)
Query: 27 VEKVAKQQQSQASEIEKNKKVLFNLKNELHELEKEIAAISAETKETERQIYQQDSAIENT 86
+E K S+ E K + K ++E+ ++E E ++ Q
Sbjct: 1 MEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQ------- 53
Query: 87 KLHCDSLETQIKSLHSENVKLKFDIETAQEDFEEHMIKYNAYYAKIKAHKNSLGEV---- 142
+ET+ + L SEN +L+ ++ET +E FE ++++ Y +I A ++ L +
Sbjct: 54 ---LQQIETRNRDLLSENNRLRMELETIKEKFE---VQHSEGYRQISALEDDLAQTKAIK 107
Query: 143 ESKWSFMTELHEKRDFVKKLKTMKEELMQDLQNPGGNRITQVQEDITNLKDKIITVKESI 202
+ ++ EL + D +++ K ++D + R+ Q E L+ + + KE++
Sbjct: 108 DQLQKYIRELEQANDDLERAKRATIMSLEDFE----QRLNQAIERNAFLESE-LDEKENL 162
Query: 203 IEKTCFLEEEKKTHEKLRKEIEVQHKR 229
+E L++E + LR+E+ VQ K+
Sbjct: 163 LESVQRLKDEAR---DLRQELAVQQKQ 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,261,939
Number of Sequences: 37866
Number of extensions: 389752
Number of successful extensions: 4970
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 575
Number of HSP's that attempted gapping in prelim test: 2749
Number of HSP's gapped (non-prelim): 2224
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.